Title:
METHODS AND COMPOSITIONS FOR THE TREATMENT OF CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2006024490
Kind Code:
A3
Abstract:
The present invention relates to a use of a composition comprising one or more inhibitors of the citric acid, TCA, cycle and/or one or more inhibitors of glycolysis for the manufacture of a medicament for the treatment of cellular proliferation, wherein said composition is administered into a mass of the proliferating cells.
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Inventors:
POPOWSKI YOURI (CH)
Application Number:
PCT/EP2005/009325
Publication Date:
August 10, 2006
Filing Date:
August 30, 2005
Export Citation:
Assignee:
INTERSTITIAL THERAPEUTICS (CH)
POPOWSKI YOURI (CH)
POPOWSKI YOURI (CH)
International Classes:
A61K31/19; A61K9/00; A61K31/197; A61K31/70; A61K45/00; A61K45/06; A61P13/08; A61P35/00
Domestic Patent References:
| WO1999018798A1 | 1999-04-22 | |||
| WO2003086424A1 | 2003-10-23 | |||
| WO2004062604A2 | 2004-07-29 | |||
| WO2001082926A1 | 2001-11-08 | |||
| WO2004064734A2 | 2004-08-05 |
Foreign References:
| US5889048A | 1999-03-30 |
Other References:
WAXMAN S ET AL: "HISTORY OF THE DEVELOPMENT OF ARSENIC DERIVATIVES IN CANCER THERAPY", ONCOLOGIST, ALPHAMED PRESS, US, vol. SUPPL. 2, no. 6, 2001, pages 3 - 10, XP001087583, ISSN: 1083-7159
DATABASE WPI Section Ch Week 200382, Derwent World Patents Index; Class A96, AN 2003-892536, XP002363321
DIETRICH L S ET AL: "Fluoroacetate and fluorocitrate antagonism of tumor growth; effect of these compounds on citrate metabolism in normal and neoplastic tissue.", CANCER RESEARCH. AUG 1956, vol. 16, no. 7, August 1956 (1956-08-01), pages 585 - 588, XP009059898, ISSN: 0008-5472
DATABASE WPI Section Ch Week 200460, Derwent World Patents Index; Class B04, AN 2004-621852, XP002363323
ARELLANO M ET AL: "The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate", BRITISH JOURNAL OF CANCER, vol. 77, no. 1, January 1998 (1998-01-01), pages 79 - 86, XP009059899, ISSN: 0007-0920
LAUBLE H ET AL: "The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 26 NOV 1996, vol. 93, no. 24, 26 November 1996 (1996-11-26), pages 13699 - 13703, XP002328455, ISSN: 0027-8424
DATABASE WPI Section Ch Week 200382, Derwent World Patents Index; Class A96, AN 2003-892536, XP002363321
DIETRICH L S ET AL: "Fluoroacetate and fluorocitrate antagonism of tumor growth; effect of these compounds on citrate metabolism in normal and neoplastic tissue.", CANCER RESEARCH. AUG 1956, vol. 16, no. 7, August 1956 (1956-08-01), pages 585 - 588, XP009059898, ISSN: 0008-5472
DATABASE WPI Section Ch Week 200460, Derwent World Patents Index; Class B04, AN 2004-621852, XP002363323
ARELLANO M ET AL: "The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate", BRITISH JOURNAL OF CANCER, vol. 77, no. 1, January 1998 (1998-01-01), pages 79 - 86, XP009059899, ISSN: 0007-0920
LAUBLE H ET AL: "The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 26 NOV 1996, vol. 93, no. 24, 26 November 1996 (1996-11-26), pages 13699 - 13703, XP002328455, ISSN: 0027-8424
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