Title:
METHODS AND COMPOUNDS FOR MODULATING NUCLEAR RECEPTOR COACTIVATOR BINDING
Document Type and Number:
WIPO Patent Application WO2002002488
Kind Code:
A9
Abstract:
The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. The invention includes a method for identifying residues comprising a coactivator binding site for a nuclear receptor of interest. Also included is a method of identifying agonists and/or antagonists that bind to a coactivator binding site of a nuclear receptor of interest. Agonists and antagonists of coactivator binding to nuclear receptors also are provided. The invention is exemplified by identification and manipulation of the coactivator binding site of the thyroid receptor (TR), and compounds that bind to this sites. The methods can be applied to other nuclear receptors including RAR, RXR, PPAR, VDR, ER, GR, PR, MR, and AR.
Inventors:
GUY RODNEY K
BAXTER JOHN D
DARIMONT BEATRICE
FENG WEIJUN
FLETTERICK ROBERT J
KUSHNER PETER J
WAGNER RICHARD L
WEST BRIAN L
YAMAMOTO KEITH R
GEISTLINGER TIMOTHY R
ARNOLD JAMES R
KUNTZ IRWIN D
BAXTER JOHN D
DARIMONT BEATRICE
FENG WEIJUN
FLETTERICK ROBERT J
KUSHNER PETER J
WAGNER RICHARD L
WEST BRIAN L
YAMAMOTO KEITH R
GEISTLINGER TIMOTHY R
ARNOLD JAMES R
KUNTZ IRWIN D
Application Number:
PCT/US2001/020969
Publication Date:
September 12, 2003
Filing Date:
June 29, 2001
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
C07B61/00; C07D209/82; C07D209/88; C07D225/08; C07D403/06; C07D403/14; C07K1/04; C07K7/08; C07K7/56; G01N33/68; G16B15/30; G16B20/30; (IPC1-7): C12Q1/00; G01N33/53; G01N33/543; G01N33/566; G01N33/567; A61K38/04; C07K5/00
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