METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE

Title:

METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE

Document Type and Number:

WIPO Patent Application WO/2011/119754

Kind Code:

A3

Abstract:

Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.

More Like This:

JP2017534649	Induction of bone formation by delivery of RNA encoding BMP
JP6854904	Angiogenic agents and their manufacturing methods
WO/2013/126329	COMPOSITIONS AND METHODS FOR ENHANCING NEURONAL GROWTH AND DIFFERENTIATION

Inventors:

DOVE JEFFREY S (US)
TIAN BIN (US)
SCHNEIDER RALPH (US)
COHEN JEFFREY S (US)
JANKOVIC IVAN (US)
MIGLIAZZA JOHN F (US)
WRIGHT GREGORY A (US)
YOUNG JAMES M (US)
CAMPBELL LOUIS A (US)

Application Number:

PCT/US2011/029654

Publication Date:

February 16, 2012

Filing Date:

March 23, 2011

Export Citation:

Click for automatic bibliography generation Help

Assignee:

EDWARDS LIFESCIENCES CORP (US)
DOVE JEFFREY S (US)
TIAN BIN (US)
SCHNEIDER RALPH (US)
COHEN JEFFREY S (US)
JANKOVIC IVAN (US)
MIGLIAZZA JOHN F (US)
WRIGHT GREGORY A (US)
YOUNG JAMES M (US)
CAMPBELL LOUIS A (US)

International Classes:

A61L27/38; A61F2/24; D06M10/00; D06M10/04

Foreign References:

US5770193A	1998-06-23
US20090112309A1	2009-04-30
US20080195123A1	2008-08-14
US20060228391A1	2006-10-12

Other References: