Title:
METHODS FOR DATA-DEPENDENT MASS SPECTROMETRY OF MIXED BIOMOLECULAR ANALYTES
Document Type and Number:
WIPO Patent Application WO/2016/145331
Kind Code:
A8
Abstract:
A method for mass spectral analysis of a sample containing a plurality of biomolecule species comprises: (a) mass analyzing a plurality of first-generation ion species generated from a sample portion; (b) automatically recognizing, for each of at least one biomolecule species, a respective subset of m/z ratios corresponding to respective first-generation ion species generated from the each biomolecule species; (c) selecting, from each recognized subset, a single representative m/z ratio; (d) isolating a sub-population of ions having each representative m/z ratio from ions having other m/z ratios; and (e) fragmenting each isolated sub-population of ions so as to generate second-generation ion species.
Inventors:
YIP PING F (US)
STEPHENSON JR JAMES L (US)
GVOZDYAK OKSANA (US)
STEPHENSON JR JAMES L (US)
GVOZDYAK OKSANA (US)
Application Number:
PCT/US2016/022051
Publication Date:
November 17, 2016
Filing Date:
March 11, 2016
Export Citation:
Assignee:
THERMO FINNIGAN LLC (US)
International Classes:
H01J49/00
Attorney, Agent or Firm:
COONEY, Thomas, F. (355 River Oaks ParkwaySan Jose, CA, US)
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