Title:
METHODS FOR DELIVERING NUCLEIC ACID MOLECULES INTO CELLS AND ASSESSMENT THEREOF
Document Type and Number:
WIPO Patent Application WO2002076508
Kind Code:
B1
Abstract:
Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.
Inventors:
DEJONG GARY (CA)
VANDERBYL SANDRA LOUISE (CA)
OBERLE VOLKER (NL)
HOEKSTRA DIRK (NL)
DRAYER JAN (US)
TAK PAUL PETER (NL)
VANDERBYL SANDRA LOUISE (CA)
OBERLE VOLKER (NL)
HOEKSTRA DIRK (NL)
DRAYER JAN (US)
TAK PAUL PETER (NL)
Application Number:
PCT/US2002/009262
Publication Date:
December 12, 2002
Filing Date:
March 22, 2002
Export Citation:
Assignee:
CHROMOS MOLECULAR SYSTEMS INC (CA)
DEJONG GARY (CA)
VANDERBYL SANDRA LOUISE (CA)
OBERLE VOLKER (NL)
HOEKSTRA DIRK (NL)
DRAYER JAN (US)
TAK PAUL PETER (NL)
DEJONG GARY (CA)
VANDERBYL SANDRA LOUISE (CA)
OBERLE VOLKER (NL)
HOEKSTRA DIRK (NL)
DRAYER JAN (US)
TAK PAUL PETER (NL)
International Classes:
A61K35/12; A61K38/00; A61K41/00; A61K47/24; A61K47/30; A61K47/44; A61K48/00; A61M37/00; A61P19/02; A61P29/00; C12N15/63; C12N15/88; A61K47/22; (IPC1-7): A61K48/00; A61K49/00; A61B8/00; A61B10/00; C07H21/00; C07H21/02; C07H21/04; C12N5/10; C12N5/14; C12N5/16; C12N5/22; C12N13/00; C12N15/00; C12N15/63; C12N15/65; C12N15/88; C12N15/74; C12N15/82; C12N15/85; C12P21/00; C12P21/02; C12Q1/00; C12Q1/42; C12Q1/54; C12Q1/66; C12Q1/68
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