METHODS OF DETECTING CELLS WITH A DISRUPTED CELL MEMBRANE, CELLS INFECTED WITH A PATHOGEN, DYING CELLS OR DEAD CELLS

Title:

METHODS OF DETECTING CELLS WITH A DISRUPTED CELL MEMBRANE, CELLS INFECTED WITH A PATHOGEN, DYING CELLS OR DEAD CELLS

Document Type and Number:

WIPO Patent Application WO/2009/137871

Kind Code:

A8

Abstract:

The present invention relates to methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, which can be used to treat and/or prevent diseases such as cancer, autoimmunity and infections. The present invention also relates to methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. The present invention further relates to methods of detecting cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.

Inventors:

LAHOUD MIREILLE HANNA (AU)
CAMINSCHI IRINA (AU)
SHORTMAN KEN (AU)
ZHANG JIAN-GUO (AU)
VAN DELFT MARK FRANCIS (CA)
HUANG DAVID CHING SIANG (AU)
WRIGHT MARK DEXTER (AU)

Application Number:

PCT/AU2009/000591

Publication Date:

November 25, 2010

Filing Date:

May 12, 2009

Export Citation:

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Assignee:

INST MEDICAL W & E HALL (AU)
BURNET INST (AU)
LAHOUD MIREILLE HANNA (AU)
CAMINSCHI IRINA (AU)
SHORTMAN KEN (AU)
ZHANG JIAN-GUO (AU)
VAN DELFT MARK FRANCIS (CA)
HUANG DAVID CHING SIANG (AU)
WRIGHT MARK DEXTER (AU)

International Classes:

A61K31/711; A61K31/713; A61K38/00; A61K39/395; A61P25/28; A61P35/00; A61P37/02