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Title:
METHODS OF DETECTING COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2010/089538
Kind Code:
A9
Abstract:
A method of detecting a predisposition to, or the incidence of, colorectal cancer in a faecal sample comprises, in a first step (a), detecting the presence of blood in the faecal sample, wherein detection of the presence of blood is indicative of a predisposition to, or the incidence of, colorectal cancer. The method additionally comprises, in second step (b), detecting an epigenetic modification in the DNA contained within the faecal sample, wherein detection of the epigenetic modification is indicative of a predisposition to, or the incidence of, colorectal cancer. Based upon a positive result obtained in either (a) or (b) or in both (a) and (b) a predisposition to, or the incidence of, colorectal cancer is detected. Related methods and kits involve detecting an epigenetic modification in a number of specific genes.

Inventors:
JOOST LOUWAGIE (BE)
Application Number:
PCT/GB2010/000180
Publication Date:
May 26, 2011
Filing Date:
February 03, 2010
Export Citation:
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Assignee:
MDXHEALTH SA (EC)
JOOST LOUWAGIE (BE)
SPENCER MATTHEW PETER (GB)
International Classes:
G01N33/574; C12Q1/68
Attorney, Agent or Firm:
SPENCER, Matthew, Peter et al. (Verulam Gardens70 Gray's Inn Road, London WC1X 8BT, GB)
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