Title:
METHODS OF DETECTION AND TREATMENT OF HYPER TRANSCRIPTION DISEASES
Document Type and Number:
WIPO Patent Application WO/2019/139967
Kind Code:
A1
Abstract:
Described here are methods of treatment of hyper transcription diseases in patients by administering a combination of an inhibitor of Ataxia Telangiectasia and Rad3 related Serine/Threonine protein kinase and an inhibitor of poly (ADP-ribose) polymerase (1). Described here are methods of treatment of hyper transcription diseases in patients by administering a combination of an inhibitor of Checkpoint kinase (1) and an inhibitor of poly (ADP-ribose) polymerase (1). Also provided are methods for diagnosing hyper transcription diseases in a subject by analyzing a tissue sample from the subject for changes in the plurality of R-loops or the phosphorylation levels of RNA polymerase II.
Inventors:
BISHOP ALEXANDER (US)
GORTHI APARNA (US)
ROMERO JULY (US)
LAWRENCE LIESL (US)
GORTHI APARNA (US)
ROMERO JULY (US)
LAWRENCE LIESL (US)
Application Number:
PCT/US2019/012875
Publication Date:
July 18, 2019
Filing Date:
January 09, 2019
Export Citation:
Assignee:
UNIV TEXAS (US)
International Classes:
A61K31/00; A61P35/00; G01N33/50; G01N33/574
Domestic Patent References:
| WO2017210608A1 | 2017-12-07 | |||
| WO2016179254A1 | 2016-11-10 |
Foreign References:
| US20060074073A1 | 2006-04-06 | |||
| US20090220964A1 | 2009-09-03 | |||
| US20170049771A1 | 2017-02-23 |
Other References:
SANTAMARIA NUNEZ ET AL.: "Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells", MOL CANCER THER, vol. 15, no. 10, 14 September 2016 (2016-09-14), pages 2399 - 2412, XP055625672
Attorney, Agent or Firm:
PERUMAL, Karthika (US)
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