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Title:
METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS
Document Type and Number:
WIPO Patent Application WO/2015/085172
Kind Code:
A3
Abstract:
Provided herein, in some embodiments, are methods of using certain cereblon- associated proteins, such as Aiolos, Ikaros, interferon (IFN), and IFN pathway proteins, casein kinase 1, alpha 1 (CSNK1A1), and ZFP9, as biomarkers for use in predicting and monitoring clinical sensitivity and therapeutic response to certain compounds in patients having various diseases and disorders, such as cancers (e.g., diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), myelodysplasia syndromes (MDS) and acute myeloid leukemia (AML)) and IFN-associated disorders. Also provided herein, in certain embodiments, are methods of determining the efficacy of an immunomodulatory compound.

Inventors:
TROTTER MATTHEW WILLIAM BURNELL (ES)
HAGNER PATRICK (US)
HAVENS COURTNEY G (US)
CHOPRA RAJESH (US)
GANDHI ANITA (US)
KLIPPEL ANKE (US)
WANG MARIA YINGLIN (US)
BREIDER MIKE (US)
COUTO SUZANA STURLINI (US)
REN YAN (US)
HOLLENBACH PAUL (US)
MACBETH KYLE (US)
Application Number:
PCT/US2014/068795
Publication Date:
November 12, 2015
Filing Date:
December 05, 2014
Export Citation:
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Assignee:
CELGENE CORP (US)
International Classes:
C12Q1/68
Foreign References:
US20090148853A12009-06-11
US20120035347A12012-02-09
US20130302323A12013-11-14
US20130177644A12013-07-11
Other References:
See also references of EP 3077548A4
Attorney, Agent or Firm:
WEISSER, Tamera et al. (222 East 41st StreetNew York, NY, US)
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