Title:
METHODS FOR DETERMINING RESPONSIVENESS TO A DRUG BASED UPON DETERMINATION OF RAS MUTATION AND/OR RAS AMPLIFICATION
Document Type and Number:
WIPO Patent Application WO/2011/109625
Kind Code:
A4
Abstract:
The present disclosure provides methods for predicting the sensitivity (e.g., responsiveness) of a cell and/or biological sample obtained from a subject (e.g., a human) to a drug (e.g., a DHFR inhibitor). Such methods may comprise determining the presence or absence of one or more Ras mutations and/or determining the presence or absence of an amplification of the Ras gene in the cell and/or biological sample. The methods may be used to predict the responsiveness of a subject to treatment with a drug.
Inventors:
BACUS SARAH S (US)
Application Number:
PCT/US2011/027040
Publication Date:
November 10, 2011
Filing Date:
March 03, 2011
Export Citation:
Assignee:
TARGETED MOLECULAR DIAGNOSTICS LLC (US)
BACUS SARAH S (US)
BACUS SARAH S (US)
International Classes:
C12Q1/68
Attorney, Agent or Firm:
BETTI, Christopher J. et al. (P.O. Box 1135Chicago, Illinois, US)
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