Title:
METHODS FOR THE DEVELOPMENT OF METZINCIN-SELECTIVE CATALYTIC CLEFT DIRECTED ANTIBODIES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2012/042391
Kind Code:
A3
Abstract:
In some aspects, general methods to develop highly selective inhibitory antibodies towards members of the metzincin superfamily of metalloproteases and their application for therapeutic and diagnostic uses are provided. The methods employ the generation of novel catalytic cleft-directed antibodies with neutralising selectivity for the targeted metzincin metalloendoproteinase employing immunogenic peptides encompassing the consensus metzincin catalytic motif. In some aspects, methods include the employment of such antibodies for therapeutic purposes and/or as an inhibitory component of an assay system allowing discrimination between the activity of the targeted metzincin and other endogenous metzincins within a biological sample. Such assays may be employed for diagnostic or prognostic purposes.
Inventors:
RAHMAN SALMAN (GB)
PATEL YATIN (GB)
PATEL YATIN (GB)
Application Number:
PCT/IB2011/002860
Publication Date:
August 23, 2012
Filing Date:
October 01, 2011
Export Citation:
Assignee:
RAHMAN SALMAN (GB)
PATEL YATIN (GB)
PATEL YATIN (GB)
International Classes:
C07K16/40; C07K16/28
Domestic Patent References:
| WO2009118660A2 | 2009-10-01 | |||
| WO2009101968A1 | 2009-08-20 | |||
| WO2002066057A2 | 2002-08-29 |
Foreign References:
| EP2186894A1 | 2010-05-19 | |||
| EP2174956A1 | 2010-04-14 | |||
| EP1609804A1 | 2005-12-28 |
Other References:
F. X. GOMIS-RUTH: "Catalytic Domain Architecture of Metzincin Metalloproteases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 23, 5 June 2009 (2009-06-05), pages 15353 - 15357, XP055030458, ISSN: 0021-9258, DOI: 10.1074/jbc.R800069200
GILLIAN MURPHY: "Fell-Muir Lecture: Metalloproteinases: from demolition squad to master regulators", INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, vol. 91, no. 4, 1 August 2010 (2010-08-01), pages 303 - 313, XP055030656, ISSN: 0959-9673, DOI: 10.1111/j.1365-2613.2010.00736.x
GILLIAN MURPHY: "Fell-Muir Lecture: Metalloproteinases: from demolition squad to master regulators", INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, vol. 91, no. 4, 1 August 2010 (2010-08-01), pages 303 - 313, XP055030656, ISSN: 0959-9673, DOI: 10.1111/j.1365-2613.2010.00736.x
Attorney, Agent or Firm:
KIRKHAM, Nicholas, A. et al. (St. Botolph's House7-9 St. Botolph's Roa, Sevenoaks Kent TN13 3AJ, GB)
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