METHODS AND DEVICES FOR PREDICTING DIMERIZATION IN NUCLEIC ACID AMPLIFICATION REACTION

Title:

METHODS AND DEVICES FOR PREDICTING DIMERIZATION IN NUCLEIC ACID AMPLIFICATION REACTION

Document Type and Number:

WIPO Patent Application WO/2024/072164

Kind Code:

A1

Abstract:

In an embodiment of the disclosure, a computer-implemented method for predicting a dimerization in a nucleic acid amplification reaction comprises accessing a dimer prediction model learned by a transfer learning method; providing an input data to the dimer prediction model, wherein the input data comprise a sequence data of an oligonucleotide; and obtaining a prediction result for the dimerization of the oligonucleotide from the dimer prediction model.

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Inventors:

JANG JONG HA (KR)
KIM HYUN HO (KR)
SHIN BO KYU (KR)
JUNG DONG MIN (KR)

Application Number:

PCT/KR2023/015137

Publication Date:

April 04, 2024

Filing Date:

September 27, 2023

Export Citation:

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Assignee:

SEEGENE INC (KR)

International Classes:

G16C20/30; G16B30/10; G16C20/60; G16C20/70; G16C20/80

Foreign References:

KR102448484B1	2022-09-28
US20220270711A1	2022-08-25

Other References:

XIE NINA G., WANG MICHAEL X., SONG PING, MAO SHIQI, WANG YIFAN, YANG YUXIA, LUO JUNFENG, REN SHENGXIANG, ZHANG DAVID YU: "Designing highly multiplex PCR primer sets with Simulated Annealing Design using Dimer Likelihood Estimation (SADDLE)", NATURE COMMUNICATIONS, vol. 13, no. 1, 11 April 2022 (2022-04-11), XP055960639, DOI: 10.1038/s41467-022-29500-4
KOTETSU KAYAMA: "Prediction of PCR amplification from primer and template sequences using recurrent neural network", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 11, no. 1, 5 April 2022 (2022-04-05), US , pages 7493, XP093155771, ISSN: 2045-2322, DOI: 10.1038/s41598-021-86357-1
ANDREW D. JOHNSTON: "PrimerROC: accurate condition-independent dimer prediction using ROC analysis", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 9, no. 1, 18 January 2019 (2019-01-18), US , pages 209, XP093155784, ISSN: 2045-2322, DOI: 10.1038/s41598-018-36612-9

Attorney, Agent or Firm:

FIRSTLAW P. C. (KR)

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