Title:
METHODS AND DEVICES FOR PROMOTING NERVE GROWTH AND REGENERATION
Document Type and Number:
WIPO Patent Application WO/2019/135812
Kind Code:
A3
Abstract:
In one aspect, methods of promoting asymmetric nerve growth and/or regeneration are described herein. In some embodiments, such a method comprises exposing a population of transected or severed nerves to a first molecular growth cue and to a second molecular growth cue. The population of transected nerves comprises one or more nerves of a first nerve type and one or more nerves of a second nerve type differing from the first nerve type. Additionally, the first molecular growth cue preferentially promotes growth of the first nerve type, as compared to the second nerve type. Similarly, the second molecular growth cue preferentially promotes growth of the second nerve type, as compared to the first nerve type. Moreover, the first molecular growth cue is spatially separated from the second molecular growth cue.
Inventors:
ROMERO-ORTEGA MARIO (US)
ANAND SANJAY (US)
ALSMADI NESREEN (US)
BENDALE GEETANJALI (US)
ANAND SANJAY (US)
ALSMADI NESREEN (US)
BENDALE GEETANJALI (US)
Application Number:
PCT/US2018/055556
Publication Date:
September 19, 2019
Filing Date:
October 12, 2018
Export Citation:
Assignee:
UNIV TEXAS (US)
International Classes:
A61K38/18; A61L27/54; A61L31/16; C12N5/0793
Foreign References:
| US20160000965A1 | 2016-01-07 | |||
| US20080057129A1 | 2008-03-06 | |||
| US20150374887A1 | 2015-12-31 |
Other References:
LOTFI ET AL.: "Modality-specific axonal regeneration: toward selective regenerative neural interfaces", FRONT NEUROENG, vol. 4, no. 11, 12 October 2011 (2011-10-12), pages 1 - 11, XP055636171
LUKOVIC ET AL.: "Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation", SCI REP, vol. 5, 9640, 10 April 2015 (2015-04-10), pages 1 - 7, XP055636172
FORREST ET AL.: "Peripheral injury of pelvic visceral sensory nerves alters GFRa (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord", FRONT NEUROANAT, vol. 9, 43, 10 April 2015 (2015-04-10), pages 1 - 13, XP055636173
BASHAW ET AL.: "Signaling from axon guidance receptors", COLD SPRING HARB PERSPECT BIOL, vol. 2, a001941, 24 March 2010 (2010-03-24), pages 1 - 16, XP055636178
TANG ET AL.: "Semaphorin3A inhibits nerve growth factor-induced sprouting of nociceptive afferents in adult rat spinal cord", J NEUROSCI, vol. 24, 28 January 2004 (2004-01-28), pages 819 - 827, XP055636180
MI ET AL.: "Pleiotrophin is a neurotrophic factor for spinal motor neurons", PROC NATL ACAD SCI USA, vol. 104, 5 March 2007 (2007-03-05), pages 4664 - 4669, XP055636183
STASSART ET AL.: "A role for Schwann cell -derived neuregulin-1 in remyelination", NAT NEUROSCI, vol. 16, 9 December 2012 (2012-12-09), pages 48 - 54
ALSMADI ET AL.: "Coiled polymeric growth factor gradients for multi-luminal neural chemotaxis", BRAIN RES, vol. 1619, 21 March 2015 (2015-03-21), pages 72 - 83, XP055636185
ANAND ET AL.: "Asymmetric Sensory-Motor Regeneration of Transected Peripheral Nerves Using Molecular Guidance Cues", SCI REP, vol. 7, 30 October 2017 (2017-10-30), pages 1 - 17, XP055636189
LUKOVIC ET AL.: "Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation", SCI REP, vol. 5, 9640, 10 April 2015 (2015-04-10), pages 1 - 7, XP055636172
FORREST ET AL.: "Peripheral injury of pelvic visceral sensory nerves alters GFRa (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord", FRONT NEUROANAT, vol. 9, 43, 10 April 2015 (2015-04-10), pages 1 - 13, XP055636173
BASHAW ET AL.: "Signaling from axon guidance receptors", COLD SPRING HARB PERSPECT BIOL, vol. 2, a001941, 24 March 2010 (2010-03-24), pages 1 - 16, XP055636178
TANG ET AL.: "Semaphorin3A inhibits nerve growth factor-induced sprouting of nociceptive afferents in adult rat spinal cord", J NEUROSCI, vol. 24, 28 January 2004 (2004-01-28), pages 819 - 827, XP055636180
MI ET AL.: "Pleiotrophin is a neurotrophic factor for spinal motor neurons", PROC NATL ACAD SCI USA, vol. 104, 5 March 2007 (2007-03-05), pages 4664 - 4669, XP055636183
STASSART ET AL.: "A role for Schwann cell -derived neuregulin-1 in remyelination", NAT NEUROSCI, vol. 16, 9 December 2012 (2012-12-09), pages 48 - 54
ALSMADI ET AL.: "Coiled polymeric growth factor gradients for multi-luminal neural chemotaxis", BRAIN RES, vol. 1619, 21 March 2015 (2015-03-21), pages 72 - 83, XP055636185
ANAND ET AL.: "Asymmetric Sensory-Motor Regeneration of Transected Peripheral Nerves Using Molecular Guidance Cues", SCI REP, vol. 7, 30 October 2017 (2017-10-30), pages 1 - 17, XP055636189
Attorney, Agent or Firm:
ZIMMER, John P. et al. (US)
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