Title:
METHODS AND DEVICES FOR SEALING MICROCHIP RESERVOIR DEVICES
Document Type and Number:
WIPO Patent Application WO2001091902
Kind Code:
A3
Abstract:
Methods and devices are provided for mechanically sealing the reservoirs of microchip devices to prevent leakage from or between any of the reservoirs. In one embodiment, the method includes sandwiching a microchip device and a gasket material covering the reservoir openings between a front sealing frame and a backplate, such that the gasket material is compressed against the back side of the microchip device by the backplate. The front sealing frame is secured to the back sealing plate using fasteners or welding. The gasket material is preferably a flexible polymeric sheet, which is biocompatible and compatible with the reservoir contents. In another embodiment, a composite backplate is used in place of the back sealing plate and separate gasket material. The composite backplate can include a substrate having sealing plugs defined thereon. The composite backplate also can be designed to hold the drug, thereby combining the assembly steps of reservoir filling and sealing.
Inventors:
SHAWGO REBECCA S
SHEPPARD NORMAN F JR
CIMA MICHAEL J
SANTINI JOHN T JR
HERMAN STEPHEN J
POLITO BENJAMIN F
UHLAND SCOTT A
SHEPPARD NORMAN F JR
CIMA MICHAEL J
SANTINI JOHN T JR
HERMAN STEPHEN J
POLITO BENJAMIN F
UHLAND SCOTT A
Application Number:
PCT/US2001/017346
Publication Date:
July 18, 2002
Filing Date:
May 30, 2001
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
A61B5/00; A61K9/00; A61K9/22; A61N1/30; B01L3/00; B81B7/00; (IPC1-7): B01L3/00; G01N35/00
Foreign References:
| US5797898A | 1998-08-25 | |||
| US5516490A | 1996-05-14 | |||
| US5858770A | 1999-01-12 |
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