Title:
METHODS FOR DIAGNOSING A CEREBRAL AMYLOID ANGIOPATHY BY AMYLOID BETA AUTOANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2020/020906
Kind Code:
A3
Abstract:
The invention provides an in vitro method for diagnosing cerebral amyloid angiopathy (CAA), or for diagnosing or determining the risk of developing a complication of CAA, in a human subject, which method comprises analyzing serial dilutions of a plasma or serum sample of the subject, for determining at least one binding parameter of antibodies present therein, wherein said antibodies are anti-Αβ amyloid peptide(s) antibodies.
Inventors:
AUCOUTURIER PIERRE (FR)
CHANTRAN YANNICK (FR)
CAPRON JEAN (FR)
ALAMOWITCH SONIA (FR)
CHANTRAN YANNICK (FR)
CAPRON JEAN (FR)
ALAMOWITCH SONIA (FR)
Application Number:
PCT/EP2019/069836
Publication Date:
March 12, 2020
Filing Date:
July 23, 2019
Export Citation:
Assignee:
UNIV SORBONNE (FR)
INST NAT SANTE RECH MED (FR)
HOPITAUX PARIS ASSIST PUBLIQUE (FR)
INST NAT SANTE RECH MED (FR)
HOPITAUX PARIS ASSIST PUBLIQUE (FR)
International Classes:
G01N33/68
Foreign References:
| EP1944314A1 | 2008-07-16 | |||
| US20150094218A1 | 2015-04-02 |
Other References:
ANN-MARIE CHACKO ET AL: "Collaborative Enhancement of Antibody Binding to Distinct PECAM-1 Epitopes Modulates Endothelial Targeting", PLOS ONE, vol. 7, no. 4, 13 January 2012 (2012-01-13), pages e34958, XP055642563, DOI: 10.1371/journal.pone.0034958
RODBARD D ET AL: "Mathematical theory of radioligand assays: The kinetics of separation of bound from free", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 3, no. 3, 1 April 1972 (1972-04-01), pages 255 - 273, XP025421168, ISSN: 0022-4731, [retrieved on 19720401], DOI: 10.1016/0022-4731(72)90074-X
KIMURA AKIO ET AL: "Comparison of cerebrospinal fluid profiles in Alzheimer's disease with multiple cerebral microbleeds and cerebral amyloid angiopathy-related inflammation", JOURNAL OF NEUROLOGY - ZEITSCHRIFT FUER NEUROLOGIE, SPRINGER VERLAG, BERLIN, DE, vol. 264, no. 2, 20 December 2016 (2016-12-20), pages 373 - 381, XP036149347, ISSN: 0340-5354, [retrieved on 20161220], DOI: 10.1007/S00415-016-8362-2
STINE W B ET AL: "In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 278, no. 13, 28 March 2003 (2003-03-28), pages 11612 - 11622, XP002281314, ISSN: 0021-9258, DOI: 10.1074/JBC.M210207200
FABRIZIO PIAZZA ET AL: "Anti-amyloid [beta] autoantibodies in cerebral amyloid angiopathy-related inflammation: Implications for amyloid-modifying therapies : Anti-A[beta] Abs in CAA-ri", ANNALS OF NEUROLOGY., vol. 73, no. 4, 1 April 2013 (2013-04-01), BOSTON, US, pages 449 - 458, XP055519076, ISSN: 0364-5134, DOI: 10.1002/ana.23857
ELISA CONTI ET AL: "Increased Soluble APP[alpha], Abeta 1-42, and Anti-Abeta 1-42 Antibodies in Plasma From Down Syndrome Patients :", ALZHEIMER DISEASE AND ASSOCIATED DISORDERS., vol. 24, no. 1, 1 January 2010 (2010-01-01), US, pages 96 - 100, XP055641181, ISSN: 0893-0341, DOI: 10.1097/WAD.0b013e3181aba63a
RODBARD D ET AL: "Mathematical theory of radioligand assays: The kinetics of separation of bound from free", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 3, no. 3, 1 April 1972 (1972-04-01), pages 255 - 273, XP025421168, ISSN: 0022-4731, [retrieved on 19720401], DOI: 10.1016/0022-4731(72)90074-X
KIMURA AKIO ET AL: "Comparison of cerebrospinal fluid profiles in Alzheimer's disease with multiple cerebral microbleeds and cerebral amyloid angiopathy-related inflammation", JOURNAL OF NEUROLOGY - ZEITSCHRIFT FUER NEUROLOGIE, SPRINGER VERLAG, BERLIN, DE, vol. 264, no. 2, 20 December 2016 (2016-12-20), pages 373 - 381, XP036149347, ISSN: 0340-5354, [retrieved on 20161220], DOI: 10.1007/S00415-016-8362-2
STINE W B ET AL: "In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 278, no. 13, 28 March 2003 (2003-03-28), pages 11612 - 11622, XP002281314, ISSN: 0021-9258, DOI: 10.1074/JBC.M210207200
FABRIZIO PIAZZA ET AL: "Anti-amyloid [beta] autoantibodies in cerebral amyloid angiopathy-related inflammation: Implications for amyloid-modifying therapies : Anti-A[beta] Abs in CAA-ri", ANNALS OF NEUROLOGY., vol. 73, no. 4, 1 April 2013 (2013-04-01), BOSTON, US, pages 449 - 458, XP055519076, ISSN: 0364-5134, DOI: 10.1002/ana.23857
ELISA CONTI ET AL: "Increased Soluble APP[alpha], Abeta 1-42, and Anti-Abeta 1-42 Antibodies in Plasma From Down Syndrome Patients :", ALZHEIMER DISEASE AND ASSOCIATED DISORDERS., vol. 24, no. 1, 1 January 2010 (2010-01-01), US, pages 96 - 100, XP055641181, ISSN: 0893-0341, DOI: 10.1097/WAD.0b013e3181aba63a
Attorney, Agent or Firm:
CABINET BECKER ET ASSOCIES (FR)
Download PDF:
Previous Patent: NEAR-INFRARED (NIR) TRICARBOCYANINE N-TRIAZOLE CHROMOPHORES
Next Patent: WORKPIECE RETENTION MECHANISM FOR ORAL CARE DEVICE
Next Patent: WORKPIECE RETENTION MECHANISM FOR ORAL CARE DEVICE