METHODS OF DIAGNOSIS OF CANCER, COMPOSITIONS AND METHODS OF SCREENING FOR MODULATORS OF CANCER CROSS-REFERENCES TO RELATED APPLICATIONS This application claims priority to USSN 60/323,469, filed Setember 17,2001 ; USSN 60/355,145, filed February 8,2002 ; USSN 60/369, 899, filed April 4,2002 ; USSN 60/323, 887, filed September 20,2001 ; USSN 60/355,257, filed February 8,2002 ; USSN 60/325,114, filed September 25,2001 ; USSN 60/340,944, filed October 29,2001 ; USSN 60/350,666, filed November 13,2001 ; and USSN 60/372,246, filed April 12,2002 ; each of which is incorporated herein by reference for all purposes.

FIELD OF THE INVENTION The invention relates to the identification of nucleic acid and protein expression profiles and nucleic acids, products, and antibodies thereto that are involved in cancer; and to the use of such expression profiles and compositions in the diagnosis, prognosis, and therapy of cancer.

The invention further relates to methods for identifying and using agents and/or targets that modulate cancer.

BACKGROUND OF THE INVENTION Cancer is a major cause of morbidity in the United States. For example, in 1996, the American Cancer Society estimated that 1,359, 150 people were diagnosed with a malignant neoplasm and 554,740 died from one of these diseases. Cancer is responsible for 23.9 percent of all American deaths and is exceeded only by heart disease as a cause of mortality (33 percent). Unfortunately, cancer mortality is increasing and sometime early in this century, cancer is expected to become the leading cause of mortality in the United States as it already is in Japan.

Cancers share the charactaristic of disordered control over normal cell division, growth, and differentiation. Their initial clinical manifestations are extremely heterogeneous, with over 70 types of cancer arising in virtually every organ and tissue of the body. Moreover, some of those similarly classified cancer types may represent multiple different molecular diseases.

Unfortunately, some cancers may be virtually asymptomatic until late in the disease course, when treatment is more difficult, and prognosis grim.

Treatment for cancer typically includes surgery, chemotherapy, and/or radiation therapy.

Although nearly 50 percent of cancer patients can be effectively treated using these methods, the current therapies all induce serious side effects which diminish quality of life. The identification of novel therapeutic targets and diagnostic markers will be important for improving the diagnosis and treatment of cancer patients.

Recent advances in molecular medicine have increased the interest in tumor-specific antigens that could serve as targets for various immunotherapeutic or small molecule strategies.

Antigens suitable for immunotherapeutic strategies should be highly expressed in cancer tissues, preferably accessible from the vasculature and at the cell surface, and ideally not expressed in normal adult tissues. Expression in tissues that are dispensable for life, however, may be tolerated, e. g. , reproductive organs. Examples of antigens that are currently available for the detection and treatment of certain cancers include Her2/neu and the B-cell antigen CD20.

Humanized monclonal antibodies directed to Her2/neu (Herceptin (g)/trastuzumab) are currently in use for the treatment of metastatic breast cancer. See Ross and Fletcher (1998) Stem Cells 16: 413-428. Similarly, anti-CD20 monoclonal antibodies (Rituxint/rituximab) are used to effectively treat non-Hodgkin's lymphoma. See Maloney, et al. (1997) Blood 90: 2188-2195; Leget and Czuczman (1998) Curr. Opin. Oncol. 10: 548-551.

The elucidation of a role for novel proteins and compounds in disease states for identification of therapeutic targets and diagnostic markers is valuable for improving the current treatment of cancer patients. Accordingly, provided herein are molecular targets for therapeutic intervention in various defined cancers. Additionally, provided herein are methods that can be used in diagnosis and prognosis of cancer. Further provided are methods that can be used to screen candidate bioactive agents for the ability to modulate cancer.

SUMMARY OF THE INVENTION The present invention provides methods for determining the presence or absence of a pathological cell in a patient, the method comprising detecting a nucleic acid comprising a sequence at least 80% identical to a sequence as described in Tables 2A-68 in a biological sample from the patient, thereby determining the presence or absence of the pathological cell.

In certain embodiments of the method, the pathology is described in Table 1, including a cancer; the biological sample comprises isolated nucleic acids; the nucleic acids are mRNA ; the biological sample is tissue from an organ which is affected by the pathology of Table 1, including a cancer; a further step is used of amplifying nucleic acids before the step of detecting

the nucleic acid; the detecting is of a protein encoded by the nucleic acid; the nucleic acid comprises a sequence as described in Tables 2A-68; the detecting step is carried out by using a labeled nucleic acid probe, utilizing a biochip comprising at sequence at least 80% identical to a sequence as described in Tables 2A-68, or detecting a polypeptide encoded by the nucleic acid; or the patient is undergoing a therapeutic regimen to treat the pathology of Table 1, or is suspected of having the pathology or cancer.

Compostions are also provided, e. g., an isolated nucleic acid molecule comprising a <BR> <BR> sequence as described in Tables 2A-68, including, e. g. , those which are labeled; an expression vector comprising such nucleic acid; a host cell comprising such expression vector; an isolated polypeptide which is encoded by such a nucleic acid molecule comprising a sequence as described in Tables 2A-68; or an antibody that specifically binds the polypeptide. In particular embodiments, the antibody is: conjugated to an effector component, is conjugated to a <BR> <BR> detectable label (including, e. g. , a fluorescent label, a radioisotope, or a cytotoxic chemical), an antibody fragment, or is a humanized antibody.

Additional methods are provided, including methods for specifically targeting a compound to a pathological cell in a patient, the method comprising administering to the patient an antibody, as described, thereby providing the targetting. Others include, e. g. , methods for determining the presence or absence of a pathological cell in a patient, the methods comprising contacting a biological sample with an antibody, as described. In more particular methods, the antibody is: conjugated to an effector component, or to a fluorescent label; or the biological sample is a blood, serum, urine, or stool sample.

Further methods include those for identifying a compound that modulates a pathology- associated polypeptide, the method comprising steps of : contacting the compound with a pathology-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68; and determining the functional effect of the compound upon the polypeptide. Another drug screening assay method comprises steps of : administering a test compound to a mammal having a pathology of Table 1 or a cell isolated therefrom; and comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68 in a treated cell or mammal with the level of gene expression of the polynucleotide in a control cell or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of the pathology.

DETAILED DESCRIPTION OF THE INVENTION In accordance with the objects outlined above, the present invention provides novel methods for diagnosis and prognosis evaluation for various disorders, e. g. , angiogenesis, fibrosis, and various defined forms of cancer, including metastatic cancer, as well as methods for screening for compositions which modulate such conditions. Also provided are methods for <BR> <BR> treating such disorders or cancers. See, e. g. , American Society of Clinical Oncology (ed. 2001) ASCO Curriculum : Symptom Management Kendall/Hunt, ISBN: 0787277851 ; Bonadonna, et <BR> <BR> al. (2001) Textbook of Breast Cancer (2d ed. ) Dunitz Martin, ISBN: 1853178241 ; Devita and<BR> Hellman (eds. 2001) Cancer Principles and Practice of Oncology (2 vols. ), Lippincott Williams, ISBN: 0781723876 ; Howell, et al. (2001) Breast Cancer Isis Medical Media, ISBN: 1901865584; Kaye and Laws (2001) Brain Tumours : An Encyclopedic Approach (2d ed.) Churchill Livingstone, ISBN: 0443064261; Mihm, et al. (2001) The Melanocytic Proliferation: A Comprehensive Textbook of Pigmented Lesions Wiley-Liss, ISBN: 0471252719; Montgomery and Aaron (2001) Clinical Pathology of Soft-Tissue Tumors Marcel Dekker, ISBN: 0824702905; Petrovich, et al. (eds. 2001) Combined Modality of Central Nervous System Tumors (Medical Radiology) Springer Verlag, ISBN: 3540660534; Rosen (2001) Rosen's Breast Pathology Lippincott Williams and Wilkins, ISBN: 0781723795; Shah, et al.

(2001) Oral Cancer Isis Medical Media, ISBN: 189906687X ; Weiss and Goldblum (2001) <BR> <BR> Enzinger and Weiss's Soft Tissue Tumors (4th ed. ) Mosby, ISBN: 0323012000; Abeloff, et al.<BR> <P>(eds. 2000) Clinical Oncology (2d ed. ) Churchill Livingstone, ISBN: 044307545X; American Society of Clinical Oncology (ed. 2000) Cancer Genetics and Cancer Predisposition Testing Kendall/Hunt, ISBN: 0787276154 ; Fletcher (2000) Diagnostic Histopathologv of Tumors (2 <BR> <BR> vols. 2d ed. ) Churchill Livingstone, ISBN: 0443079927; Vogelzang (ed. 2000) Comprehensive<BR> Textbook of Genitourinarv Oncology (2d ed. ) Lippincott Williams and Wilkins, ISBN: 0683306456; Holland, et al. (eds. 2000) Holland-Frei Cancer Medicine (Book with CD-ROM 5th ed. ) Decker, ISBN: 1550091131 ; Turrisi, et al. (2000) Lung Cancer Isis Medical Media, ISBN: 1901865428; Bartolozzi and Lencioni (eds. 1999) Liver Malignancies : Diagnostic and Interventional Radiology (Medical Radiology) Springer Verlag, ISBN: 3540647562; Gasparini (ed. 1999) Prognostic Variables in Node-Negative and Node-Positive Breast Cancer Kluwer, ISBN: 0792384474; Hansen (ed. 1999) The LASLC Textbook of Lung Cancer: International Association for the Study of Lung Cancer Dunitz Martin, ISBN: 1853177083; Raghavan, et al. <BR> <BR> <P>(eds. 1999) Textbook of Uncommon Cancer (2nd ed. ) Wiley, ISBN: 0471929212; Thawley, et

al. (eds. 1999) Comprehensive Management of Head and Neck Tumors (2 vols. ) Saunders, ISBN: 0721655823; Whittaker and Holmes (eds. 1999) Leukemia and Related Disorders (3d <BR> <BR> ed. ) Blackwell Science, ISBN: 0865426074; Aapro (ed. 1998) OncoMedia: Medical Oncology (CD-ROM) Elsevier Science, ISBN: 0080427480 ; Abeloff (1998) Clinical Oncology (Library Version 2 CD-ROM Individual Version 2.0 Windows and Macintosh) Harcourt Brace, ISBN: 0443075557; Benson (ed. 1998) Gastrointestinal Oncology (Cancer Treatment and Research, CTAR 98) Kluwer, ISBN: 0792382056 ; Brambilla and Brambilla (eds. 1998) Lung Tumors: Fundamental Biology and Clinical Management (Vol 124) Marcel Dekker, ISBN: 0824701607 ; Canellos, et al. (eds. 1998) The Lymphomas Saunders, ISBN: 0721650309 ; Greenspan and Remagen (1998) Differential Diagnosis of Tumors and Tumor-Like Lesions of Bones and Joints Lippincott Williams and Wilkins Publishers, ISBN: 0397517106; Hiddemann (ed. 1998) Acute Leukemias VII: Experimental Approaches and Novel Therapies (Haematologie Und Bluttransfusion, Vol 39), Springer Verlag, ISBN: 3540635041; Husband and Reznek (1998) Imaging in Oncology (2 vols. ) Mosby, ISBN: 1899066489; Leibel and Phillips (eds. 1998) Textbook of Radiation Oncology Saunders, ISBN: 0721653367; Maloney and Miller (eds.

1998) Cutaneous Oncology : Pathophysiology, Diagnosis, and Management Blackwell Science, ISBN: 0865425175; Mittal, et al. (eds. 1998) Advances in Radiation Therapy Kluwe, ISBN: 0792399811 ; Oldham (ed. 1998) Principles of Cancer Biotherapy (3d ed. ) Kluwer, ISBN: 0792335074; Ozols (ed. 1998) Gynecologic Oncology Kluwer, ISBN: 0792380703; Parkin, et al. (eds. 1998) Cancer Incidence in Five Continents (Iarc Scientific Publications, No 143) Oxford University Press, ISBN: 9283-221435 ; Perez and Brady (eds. 1998) Principles and Practice of Radiation Oncology Lippincott Williams and Wilkins, ISBN: 0397584164; Black, et al. (eds. 1997) Cancer of the Nervous System Blackwell Science, ISBN: 0865423849; Bonadonna, et al. (1997) Textbook of Breast Cancer: A Clinical Guide to Therapy Blackwell Science, ISBN: 1853173487; Pollock (ed. 1997) Surgical Oncolosv Kluwer. ISBN: 0792399005; Sheaves, et al. (eds. 1997) Clinical Endocrine Oncology Blackwell Science, ISBN: 086542862X; Vahrson (1997) Radiation Oncology of Gynecological Cancers Springer Verlag, ISBN: 0387567682; Walterhouse and Cohn (eds. 1997) Diagnostic and Therapeutic Advances in Pediatric Oncology Kluwer, ISBN: 0792399781; Aisner (ed. 1996) Comprehensive Textbook of Thoracic Oncology Lippincott, Williams and Wilkins, ISBN: 0683000624; Bertino, et al. (eds. 1996) Encyclopedia of Cancer (3 vols. ) Academic, ISBN: 012093230X ; Cavalli, et al. (1996) Textbook of Medical Oncolog Dunitz Martin, ISBN: 1853172901;

Peckham, et al. (eds. 1995) Oxford Textbook of Oncology (2-Vols. ) Oxford University Press, ISBN: 0192616854; and Freireich and Kantarjian (eds. 1996) Molecular Genetics and Therapy of Leukemia (Cancer Treatment and Research, V. 84) Kluwer, ISBN: 0792339126.

In particular, identification of markers selectively expressed on defined cancers allows for use of that expression in diagnostic, prognostic, or therapeutic methods. As such, the <BR> <BR> invention defines various compositions, e. g. , nucleic acids, polypeptides, antibodies, and small molecule agonists/antagonists, which will be useful to selectively identify those markers. For example, therapeutic methods may take the form of protein therapeutics which use the marker expression for selective localization or modulation of function (for those markers which have a causative disease effect), for vaccines, identification of binding partners, or antagonism, e. g., using antisense or RNAi. The markers may be useful for molecular characterization of subsets <BR> <BR> of the diseases, e. g. , as provided in Table 1, which subsets may actually require very different treatments. Moreover, the markers may also be important in related diseases to the specific disorders and cancers, e. g. , which affect similar tissues in non-malignant diseases, or have similar mechanisms of induction/maintenance. Metastatic processes or characteristics may also be targeted. Diagnostic and prognostic uses are made available, e. g. , to subset related but distinct diseases, or to determine treatment strategy. The detection methods may be based upon nucleic acid, e. g., PCR or hybridization techniques, or protein, e. g. , ELISA, imaging, IHC, etc.

The diagnosis may be qualitative or quantitative, and may detect increases or decreases in expression levels.

Tables 2B-66C provide unigene cluster identification numbers for the nucleotide sequence of genes that exhibit increased or decreased expression in cancer samples, particularly sequences involved in angiogenisis, prostate cancer (including androgen independent and taxol resistant prostate cancer), breast cancer, colorectal cancer, cervical cancer, bladder cancer, lung cancer, ovarian cancer, uterine cancer, glioblastoma, Ewing sarcoma, and lung fibrosis. Tables 2A-67 also provide an exemplar accession number that provides a nucleotide sequence that is part of the unigene cluster.

Definitions The term"cancer protein"or"cancer polynucleotide"or"cancer-associated transcript" refers to nucleic acid and polypeptide polymorphic variants, alleles, mutants, and interspecies homologues that: (1) have a nucleotide sequence that has greater than about 60% nucleotide sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably about 92%, 94%, 96%, 97%,

98%, or 99% or greater nucleotide sequence identity, preferably over a region of over a region of at least about 25,50, 100,200, 500,1000, or more nucleotides, to a nucleotide sequence of or <BR> <BR> associated with a gene of Tables 1-68; (2) bind to antibodies, e. g. , polyclonal antibodies, raised against an immunogen comprising an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1-68, and conservatively modified variants thereof; (3) specifically hybridize under stringent hybridization conditions to a nucleic acid sequence, or the complement thereof of Tables 1-68 and conservatively modified variants thereof; or (4) have an amino acid sequence that has greater than about 60% amino acid sequence identity, 65%, 70%, 75%, 80%, 85%, preferably 90%, 91%, 93%, 95%, 97%, 98%, or 99% or greater amino sequence identity, preferably over a region of over a region of at least about 25, 50, 100,200, 500,1000, or more amino acids, to an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1-68. A polynucleotide or polypeptide sequence is typically from a mammal including, but not limited to, primate, e. g. , human; rodent, e. g. , rat, mouse, hamster; cow, pig, horse, sheep, or other mammal. A"cancer polypeptide"and a "cancer polynucleotide, "include both naturally occurring or recombinant forms.

A"full length"cancer protein or nucleic acid refers to a cancer polypeptide or polynucleotide sequence, or a variant thereof, that contains elements normally contained in one or more naturally occurring, wild type cancer polynucleotide or polypeptide sequences. The "full length"may be prior to, or after, various stages of post-translational processing or splicing, including alternative splicing.

"Biological sample"as used herein is a sample of biological tissue or fluid that contains <BR> <BR> nucleic acids or polypeptides, e. g. , of a cancer protein, polynucleotide, or transcript. Such<BR> samples include, but are not limited to, tissue isolated from primates, e. g. , humans, or rodents,<BR> e. g. , mice, and rats. Biological samples may also include sections of tissues such as biopsy and autopsy samples, frozen sections taken for histologic purposes, archival samples, blood, plasma, serum, sputum, stool, tears, mucus, hair, skin, etc. Biological samples also include explants and primary and/or transformed cell cultures derived from patient tissues. A biological sample is typically obtained from a eukaryotic organism, most preferably a mammal such as a primate e. g. , chimpanzee or human; cow; dog; cat; a rodent, e. g. , guinea pig, rat, mouse; rabbit; or a bird; reptile; or fish. Livestock and domestic animals are of interest.

"Providing a biological sample"means to obtain a biological sample for use in methods described in this invention. Most often, this will be done by removing a sample of cells from an

animal, but can also be accomplished by using previously isolated cells (e. g. , isolated by another person, at another time, and/or for another purpose), or by performing the methods of the invention in vivo. Archival tissues or materials, having treatment or outcome history, will be particularly useful.

The terms"identical"or percent"identity, "in the context of two or more nucleic acids or polypeptide sequences, refer to two or more sequences or subsequences that are the same or <BR> <BR> have a specified percentage of amino acid residues or nucleotides that are the same (e. g. , about 70% identity, preferably 75%, 80%, 85%, 90%, 91%, 93%, 95%, 97%, 98%, 99%, or higher identity over a specified region, when compared and aligned for maximum correspondence over a comparison window or designated region) as measured using, e. g. , a BLAST or BLAST 2.0 sequence comparison algorithms with default parameters described below, or by manual alignment and visual inspection (see, e. g. , NCBI web site http://www. ncbi. nlm. nih. gov/BLAST/ or the like). Such sequences are then said to be"substantially identical."This definition also refers to, or may be applied to, the complement of a test sequence. The definition also includes sequences that have deletions and/or insertions, substitutions, and naturally occurring, e. g., polymorphic or allelic variants, and man-made variants. As described below, the preferred algorithms can account for gaps and the like. Preferably, identity exists over a region that is at least about 25 amino acids or nucleotides in length, or more preferably over a region that is 50- 100 amino acids or nucleotides in length.

For sequence comparison, typically one sequence acts as a reference sequence, to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are entered into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Preferably, default program parameters can be used, or alternative parameters can be designated. The sequence comparison algorithm then calculates the percent sequence identities for the test sequences relative to the reference sequence, based on the program parameters.

A"comparison window", as used herein, includes reference to a segment of contiguous positions selected from the group consisting typically of from 20 to 600, usually about 50 to about 200, more usually about 100 to about 150, in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned. Methods of alignment of sequences for comparison are well-known.

Optimal alignment of sequences for comparison can be conducted, e. g. , by the local homology

algorithm of Smith and Waterman (1981) Adv. Appl. Math. 2: 482-489, by the homology alignment algorithm of Needleman and Wunsch (1970) J. Mol. Biol. 48: 443-453, by the search for similarity method of Pearson and Lipman (1988) Proc. Nat'1. Acad. Sci. USA 85: 2444-244S, by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, WI), or by manual alignment and visual inspection (see, e. g. , Ausubel, et al. (eds.

1995 and supplements) Current Protocols in Molecular Biology Wiley).

Preferred examples of algorithms that are suitable for determining percent sequence identity and sequence similarity include the BLAST and BLAST 2.0 algorithms, which are described in Altschul, et al. (1977) Nuc. Acids Res. 25: 3389-3402 and Altschul, et al. (1990) J.

Mol. Biol. 215: 403-410. BLAST and BLAST 2.0 are used, with the parameters described herein, to determine percent sequence identity for the nucleic acids and proteins of the invention. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www. ncbi. nhn. nih. gov/). This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the <BR> <BR> neighborhood word score threshold (Altschul, et al. , supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased.-Cumulative scores are calculated using, e. g., for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always > 0) and N (penalty score for mismatching residues; always < 0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension of the word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative- scoring residue alignments ; or the end of either sequence is reached. The BLAST algorithm parameters W, T, and X determine the sensitivity and speed of the alignment. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, M=5, N=-4 and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a wordlength of 3, and expectation (E) of 10, and the BLOSUM62

scoring matrix (see Henikoff and Henikoff (1992) Proc. Natl. Acad. Sci. USA 89: 10915-919) alignments (B) of 50, expectation (E) of 10, M=5, N=-4, and a comparison of both strands.

The BLAST algorithm also performs a statistical analysis of the similarity between two sequences. See, e. g., Karlin and Altschul (1993) Proc. Nat'1. Acad. Sci. USA 90: 5873-5787.

One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P (N)), which provides an indication of the probability by which a match between two nucleotide or amino acid sequences would occur by chance. For example, a nucleic acid is considered similar to a reference sequence if the smallest sum probability in a comparison of the test nucleic acid to the reference nucleic acid is less than about 0.2, more preferably less than about 0.01, and most preferably less than about 0.001. Log values may be negative large numbers, e. g. , 5,10, 20,30, 40,40, 70,90, 110,150, 170, etc.

An indication that two nucleic acid sequences are substantially identical is that the polypeptide encoded by the first nucleic acid is immunologically cross reactive with the antibodies raised against the polypeptide encoded by the second nucleic acid. Thus, a polypeptide is typically substantially identical to a second polypeptide, e. g. , where the two peptides differ only by conservative substitutions. Another indication that two nucleic acid sequences are substantially identical is that the two molecules or their complements hybridize to each other under stringent conditions. Yet another indication that two nucleic acid sequences are substantially identical is that the same primers can be used to amplify the sequences.

A"host cell"is a naturally occurring cell or a transformed cell that contains an expression vector and supports the replication or expression of the expression vector. Host cells may be cultured cells, explants, cells in vivo, and the like. Host cells may be prokaryotic cells such as E. coli, or eukaryotic cells such as yeast, insect, amphibian, or mammalian cells such as <BR> <BR> CHO, HeLa, and the like (see, e. g. , the American Type Culture Collection catalog or web site, www. atcc. org).

The terms"isolated, ""purified,"or"biologically pure"refer to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. A protein or nucleic acid that is the predominant species present in a preparation is substantially purified. In particular, an isolated nucleic acid is separated from some open reading frames that naturally flank the gene and encode proteins other than protein

encoded by the gene. The term"purified"in some embodiments denotes that a nucleic acid or protein gives rise to essentially one band in an electrophoretic gel. Preferably, it means that the nucleic acid or protein is at least about 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure."Purify"or"purification"in other embodiments means removing at least one contaminant or component from the composition to be purified. In this sense, <BR> <BR> purification does not require that the purified compound be homogeneous, e. g. , 100% pure.<BR> <P>The terms"polypeptide, ""peptide,"and"protein"are used interchangeably herein to refer to a polymer of amino acid residues. The terms apply to amino acid polymers in which one or more amino acid residue is an artificial chemical mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers, those containing modified residues, and non-naturally occurring amino acid polymers.

The term"amino acid"refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function similarly to the naturally occurring amino acids. Naturally occurring amino acids are those encoded by the genetic code, as well as those amino acids that are later modified, e. g., hydroxyproline,-carboxyglutamate, and O- phosphoserine. Amino acid analogs refers to compounds that have the same basic chemical <BR> <BR> structure as a naturally occurring amino acid, e. g. , an ex carbon that is bound to a hydrogen, a<BR> carboxyl group, an amino group, and an R group, e. g. , homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs may have modified R groups (e. g., norleucine) or modified peptide backbones, but retain somebasic chemical structure as a naturally occurring amino acid. Amino acid mimetic refers to a chemical compound that has a structure that is different from the general chemical structure of an amino acid, but that functions similarly to another amino acid.

Amino acids may be referred to herein by either their commonly known three letter symbols or by the one-letter symbols recommended by the IUPAC-IUB Biochemical Nomenclature Commission. Nucleotides, likewise, may be referred to by their commonly accepted single-letter codes.

"Conservatively modified variant"applies to both amino acid and nucleic acid sequences. With respect to particular nucleic acid sequences, conservatively modified variants refers to those nucleic acids which encode identical or essentially identical amino acid sequences, or where the nucleic acid does not encode an amino acid sequence, to essentially <BR> <BR> identical or associated, e. g. , naturally contiguous, sequences. Because of the degeneracy of the

genetic code, a large number of functionally identical nucleic acids encode most proteins. For instance, the codons GCA, GCC, GCG, and GCU each encode the amino acid alanine. Thus, at each position where an alanine is specified by a codon, the codon can be altered to another of the corresponding codons described without altering the encoded polypeptide. Such nucleic acid variations are"silent variations, "which are one species of conservatively modified variations. Every nucleic acid sequence herein which encodes a polypeptide also describes silent variations of the nucleic acid. In certain contexts each codon in a nucleic acid (except AUG, which is ordinarily the only codon for methionine, and TGG, which is ordinarily the only codon for tryptophan) can be modified to yield a functionally similar molecule. Accordingly, a silent variation of a nucleic acid which encodes a polypeptide is implicit in a described sequence with respect to the expression product, but not necessarily with respect to actual probe sequences.

As to amino acid sequences, one of skill will recognize that individual substitutions, deletions, or additions to a nucleic acid, peptide, polypeptide, or protein sequence which alters, adds, or deletes a single amino acid or a small percentage of amino acids in the encoded sequence is a"conservatively modified variant"where the alteration results in the substitution of an amino acid with a chemically similar amino acid. Conservative substitution tables providing functionally similar amino acids are well known. Such conservatively modified variants are in addition to and do not exclude polymorphic variants, interspecies homologs, and alleles of the invention. Typically conservative substitutions include for one another: 1) Alanine (A), Glycine (G); 2) Aspartic acid (D), Glutamic acid (E); 3) Asparagine (N), Glutamine (Q); 4) Arginin (R), Lysine (K) ; 5) Isoleucine (1), Leucine (L), Methionin (M), Valine (V); 6) Phenylalanine (F), Tyrosine (Y), Tryptophan (W); 7) Serine (S), Threonine (T); and 8) Cysteine (C), Methionine (M) (see, e. g. , Creighton (1984) Proteins: Structure and Molecular Properties Freeman).

Macromolecular structures such as polypeptide structures can be described in terms of <BR> <BR> various levels of organization. For a general discussion of this organization, see, e. g. , Alberts,<BR> et al. (eds. 2001) Molecular Biology of the Cell (4th ed. ) Garland; and Cantor and Schimmel (1980) Biophysical Chemistry Part 1 : The Conformation of Biological Macromolecules Freeman. "Primary structure"refers to the amino acid sequence of a particular peptide.

"Secondary structure"refers to locally ordered, three dimensional structures within a polypeptide. These structures are commonly known as domains. Domains are portions of a

polypeptide that often form a compact unit of the polypeptide and are typically 25 to approximately 500 amino acids long. Typical domains are made up of sections of lesser organization such as stretches of-sheet and a-helices."Tertiary structure"refers to the <BR> <BR> complete three dimensional structure of a polypeptide monomer. "Quaternary structure"refers to the three dimensional structure formed, usually by the noncovalent association of independent tertiary units. Anisotropic terms are also known as energy terms.

"Nucleic acid"or"oligonucleotide"or"polynucleotide"or grammatical equivalents used herein means at least two nucleotides covalently linked together. Oligonucleotides are typically from about 5,6, 7,8, 9,10, 12,15, 25,30, 40,50, or more nucleotides in length, up to about 100 nucleotides in length. Nucleic acids and polynucleotides are a polymers of any length, including longer lengths, e. g. , 200,300, 500,1000, 2000,3000, 5000,7000, 10,000, etc. A nucleic acid of the present invention will generally contain phosphodiester bonds, although in some cases, nucleic acid analogs are included that may have at least one different linkage, e. g., phosphoramidate, phosphorothioate, phosphorodithioate, or O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach Oxford Univ.

Press); and peptide nucleic acid backbones and linkages. Other analog nucleic acids include those with positive backbones; non-ionic backbones, and non-ribose backbones, including those described in U. S. Patent Nos. 5,235, 033 and 5,034, 506, and Chapters 6 and 7 of Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids. Modifications of the ribose-phosphate backbone may be done for a <BR> <BR> variety of reasons, e. g. , to increase the stability and half-life of such molecules in physiological environments or as probes on a biochip. Mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made.

A variety of references disclose such nucleic acid analogs, including, e. g., phosphoramidate (Beaucage, et al. (1993) Tetrahedron 49: 1925-1963 and references therein; Letsinger (1970) J. Org. Chem. 35: 3800-3803; Sprinzl, et al. (1977) Eur. J. Biochem. 81: 579- 589 ; Letsinger, et al. (1986) Nucl. Acids Res. 14: 3487-499 ; Sawai, et al. (1984) Chem. Lett.

805, Letsinger, et al. (1988) J. Am. Chem. Soc. 110: 4470-4471; andPauwels, et al. (1986) Chemica Scripta 26: 141-149), phosphorothioate (Mag, et al. (1991) Nucleic Acids Res.

19: 1437-441; and U. S. Patent No. 5,644, 048), phosphorodithioate (Brill, et al. (1989) J. Am.

Chem. Soc. 111: 2321-2322), O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues : A Practical Approach, Oxford Univ. Press), and peptide nucleic acid backbones and linkages (see Egholm (1992) J. Am. Chem. Soc. 114: 1895-1897; Meier, et al. (1992) Chem. Int. Ed. Enrl. 31: 1008-1010; Nielsen (1993) Nature 365: 566-568; Carlsson, et al. (1996) Nature 380: 207, all of which are incorporated by reference). Other analog nucleic acids include those with positive backbones (Denpcy, et al. (1995) Proc. Natl.

Acad. Sci. USA 92: 6097-101; non-ionic backbones (U. S. Patent Nos. 5, 386, 023,5, 637, 684, 5,602, 240,5, 216,141, and 4,469, 863; Kiedrowski, et al. (1991) Angew. Chem. Intl. Ed. English 30: 423-426; Letsinger, et al. (1988) J. Am. Chem. Soc. 110: 4470-4471; Letsinger, et al. (1994) Nucleoside and Nucleotide 13: 1597-xxx; Chapters 2 and 3 in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580; Mesmaeker, et al. (1994) Bioorganic and Medicinal Chem. Lett. 4: 395-398 ; Jeffs, et al. (1994) J. Biomolecular NMR 34: 17; Horn, et al. (1996) Tetrahedron Lett. 37: 743-xxx) and non-ribose backbones, including those described in U. S. Patent Nos. 5,235, 033 and 5,034, 506, and Chapters 6 and 7 in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids (see Jenkins, et al. (1995) Chem. Soc. Rev. pp 169-176). Several nucleic acid analogs are described in Rawls (page 35, June 2,1997) C&E News.

Particularly preferred are peptide nucleic acids (PNA) which includes peptide nucleic acid analogs. These backbones are substantially non-ionic under neutral conditions, in contrast to the highly charged phosphodiester backbone of naturally occurring nucleic acids. This results in at least two advantages. The PNA backbone exhibits improved hybridization kinetics.

PNAs have larger changes in the melting temperature (Tm) for mismatched versus perfectly matched basepairs. DNA and RNA typically exhibit a 2-4° C drop in Tm for an internal mismatch. With the non-ionic PNA backbone, the drop is closer to 7-9° C. Similarly, due to their non-ionic nature, hybridization of the bases attached to these backbones is relatively insensitive to salt concentration. In addition, PNAs are not degraded by cellular enzymes, and thus can be more stable.

The nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence. The depiction of a single strand also defines the sequence of the complementary strand; thus the sequences described herein also

provide the complement of the sequence. The nucleic acid may be DNA, both genomic and cDNA, RNA, or a hybrid, where the nucleic acid may contain combinations of deoxyribo-and ribo-nucleotides, and combinations of bases, including uracil, adenine, thymine, cytosin, guanine, inosine, xanthine hypoxanthine, isocytosine, isoguanine, etc."Transcript"typically <BR> <BR> refers to a naturally occurring RNA, e. g. , a pre-mRNA, hnRNA, or mRNA. As used herein, the term"nucleoside"includes nucleotides and nucleoside and nucleotide analogs, and modified <BR> <BR> nucleosides such as amino modified nucleosides. In addition, "nucleoside"includes non-<BR> naturally occurring analog structures. Thus, e. g. , the individual units of a peptide nucleic acid, each containing a base, are referred to herein as a nucleoside.

A"label"or a"detectable moiety"is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, physiological, chemical, or other physical means. In general, labels fall into three classes : a) isotopic labels, which may be radioactive or heavy isotopes; b) immune labels, which may be antibodies, antigens, or epitope tags; and c) colored or fluorescent dyes. The labels may be incorporated into the cancer nucleic acids, proteins, and antibodies. For example, the label should be capable of producing, either directly or indirectly, a detectable signal. The detectable moiety may be a radioisotope, such as 3H, 14C, 32p, 35S, or 125I, electron-dense reagents, a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin, or an enzyme (e. g. , as commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins or other entities which can be made detectable such as alkaline phosphatase, beta-galactosidase, or horseradish peroxidase.

Methods are known for conjugating the antibody to the label. See, e. g., Hunter, et al. (1962) Nature 144: 945; David, et al. (1974) Biochemistry 13: 1014-1021; Pain, et al. (1981) J.

Immunol. Meth. 40: 219-230; and Nygren (1982) J. Histochem. and Cytochem. 30: 407-412.

An"effector"or"effector moiety"or"effector component"is a molecule that is bound (or linked, or conjugated), either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds, to an antibody.

The"effector"can be a variety of molecules including, e. g. , detection moieties including radioactive compounds, fluorescent compounds, enzymes or substrates, tags such as epitope tags, toxins; activatable moieties, chemotherapeutic agents; lipases; antibiotics; or radioisotopes, e. g., emitting"hard"beta, radiation.

A"labeled nucleic acid probe or oligonucleotide"is one that is bound, e. g. , covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals,

electrostatic, or hydrogen bonds to a label such that the presence of the probe may be detected by detecting the presence of the label bound to the probe. Alternatively, methods using high affinity interactions may achieve the same results where one of a pair of binding partners binds to the other, e. g. , biotin, streptavidin.

As used herein a"nucleic acid probe or oligonucleotide"is a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, e. g. , through hydrogen bond<BR> formation. As used herein, a probe may include natural (e. g. , A, G, C, or T) or modified bases<BR> (7-deazaguanosine, inosine, etc. ). In addition, the bases in a probe may be joined by a linkage other than a phosphodiester bond, preferably one that does not functionally interfere with hybridization. Thus, e. g. , probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. Probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency of the hybridization conditions. The probes are preferably directly labeled, e. g. , with<BR> isotopes, chromophores, lumiphores, chromogens, or indirectly labeled, e. g. , with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence of the probe, one can detect the presence or absence of the select sequence or subsequence. Diagnosis or prognosis may be based at the genomic level, or at the level of RNA or protein expression.

The term"recombinant"when used with reference, e. g. , to a cell, or nucleic acid, protein, or vector, indicates that the cell, nucleic acid, protein, or vector, has been modified by the introduction of a heterologous nucleic acid or protein or the alteration of a native nucleic acid or protein, or that the cell is derived from a cell so modified. Thus, e. g. , recombinant cells express genes that are not found within the native (non-recombinant) form of the cell or express native genes that are otherwise abnormally expressed, under expressed, or not expressed at all.

By the term"recombinant nucleic acid"herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid, e. g. , using polymerases and endonucleases, in a form not normally found in nature. In this manner, operably linkage of different sequences is achieved. Thus an isolated nucleic acid, in a linear form, or an expression vector formed in vitro by ligating DNA molecules that are not normally joined, are both considered recombinant for the purposes of this invention. It is understood that once a recombinant nucleic acid is made and reintroduced into a host cell or organism, it will replicate non-recombinantly, e. g. , using the in vivo cellular machinery of the host cell rather than in vitro manipulations; however, such

nucleic acids, once produced recombinantly, although subsequently replicated non- recombinantly, are still considered recombinant for the purposes of the invention.

Similarly, a"recombinant protein"is a protein made using recombinant techniques, e. g., through the expression of a recombinant nucleic acid as depicted above. A recombinant protein is distinguished from naturally occurring protein by at least one or more characteristics. The protein may be isolated or purified away from some or most of the proteins and compounds with which it is normally associated in its wild type host, and thus may be substantially pure.

An isolated protein is unaccompanied by at least some of the material with which it is normally associated in its natural state, preferably constituting at least about 0.5%, more preferably at least about 5% by weight of the total protein in a given sample. A substantially pure protein comprises at least about 75% by weight of the total protein, with at least about 80% being preferred, and at least about 90% being particularly preferred. The definition includes the production of a skin cancer protein from one organism in a different organism or host cell.

Alternatively, the protein may be made at a significantly higher concentration than is normally seen, through the use of an inducible promoter or high expression promoter, such that the protein is made at increased concentration levels. Alternatively, the protein may be in a form not normally found in nature, as in the addition of an epitope tag or amino acid substitutions, insertions and deletions, as discussed below.

The term"heterologous"when used with reference to portions of a nucleic acid indicates that the nucleic acid comprises two or more subsequences that are not normally found in the same relationship to each other in nature. For instance, the nucleic acid is typically recombinantly produced, having two or more sequences, e. g. , from unrelated genes arranged to<BR> make a new functional nucleic acid, e. g. , a promoter from one source and a coding region from another source. Similarly, a heterologous protein will often refer to two or more subsequences that are not found in the same relationship to each other in nature (e. g. , a fusion protein).

A"promoter"is typically an array of nucleic acid control sequences that direct transcription of a nucleic acid. As used herein, a promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element. A promoter also optionally includes distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription. A"constitutive"promoter is a promoter that is active under most environmental and developmental conditions. An"inducible"promoter is a promoter that is active under

environmental or developmental regulation. The term"operably linked"refers to a functional linkage between a nucleic acid expression control sequence (such as a promoter, or array of transcription factor binding sites) and a second nucleic acid sequence, e. g. , wherein the expression control sequence directs transcription of the nucleic acid corresponding to the second sequence.

An"expression vector"is a nucleic acid construct, generated recombinantly or synthetically, with a series of specified nucleic acid elements that permit transcription of a particular nucleic acid in a host cell. The expression vector can be part of a plasmid, virus, or nucleic acid fragment. Typically, the expression vector includes a nucleic acid to be transcribed in operable linkage to a promoter.

The phrase"selectively (or specifically) hybridizes to"refers to the binding, duplexing, or hybridizing of a molecule selectively to a particular nucleotide sequence under stringent hybridization conditions when that sequence is present in a complex mixture (e. g. , total cellular or library DNA or RNA).

The phrase"stringent hybridization conditions"refers to conditions under which a probe will hybridize to its target subsequence, typically in a complex mixture of nucleic acids, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. An extensive guide to the hybridization of nucleic acids is found in"Overview of principles of hybridization and the strategy of nucleic acid assays"in Tijssen (1993) Hybridization with Nucleic Probes (Laboratory Techniques in Biochemistry and Molecular Biology) (vol. 24) Elsevier. Generally, stringent conditions are selected to be about 5-10° C lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength pH. The Tm is the temperature (under defined ionic strength, pH, and nucleic concentration) at which 50% of the probes complementary to the target hybridize to the target sequence at equilibrium (as the target sequences are present in excess, at Tm, 50% of the probes are occupied at equilibrium).

Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01-1. 0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C for short probes (e. g. , about 10-50 nucleotides)<BR> and at least about 60° C for long probes (e. g. , greater than about 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.

For selective or specific hybridization, a positive signal is typically at least two times

background, preferably 10 times background hybridization. Exemplary stringent hybridization conditions can be as following: 50% formamide, 5x SSC, and 1% SDS, incubating at 42° C, or, 5x SSC, 1% SDS, incubating at 65° C, with wash in 0.2x SSC, and 0.1% SDS at 65° C. For PCR, a temperature of about 36° C is typical for low stringency amplification, although annealing temperatures may vary between about 32°-48° C depending on primer length. For high stringency PCR amplification, a temperature of about 62° C is typical, although high stringency annealing temperatures can range from about 50-65° C, depending on the primer length and specificity. Typical cycle conditions for both high and low stringency amplifications include a denaturation phase of 90-95° C for 30-120 sec, an annealing phase lasting 30-120 sec, and an extension phase of about 72° C for 1-2 min. Protocols and guidelines for low and high stringency amplification reactions are provided, e. g. , in Innis, et al. (1990) PCR Protocols: A Guide to Methods and Applications, Academic Press, NY.

Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides which they encode are substantially identical. This occurs, e. g. , when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. In such cases, the nucleic acids typically hybridize under moderately stringent hybridization conditions. Exemplary"moderately stringent hybridization conditions"include a hybridization in a buffer of 40% formamide, 1 M NaCl, 1% SDS at 37° C, and a wash in 1X SSC at 45° C. A positive hybridization is typically at least twice background.

Alternative hybridization and wash conditions can be utilized to provide conditions of similar stringency. Additional guidelines for determining hybridization parameters are provided in numerous references, e. g. , Ausubel, et al. (eds. 1991 and supplements) Current Protocols in Molecular Biology Wiley.

The phrase"functional effects"in the context of assays for testing compounds that modulate activity of a cancer protein includes the determination of a parameter that is indirectly or directly under the influence of the cancer protein or nucleic acid, e. g. , a physiological, functional, physical, or chemical effect, such as the ability to decrease cancer. It includes ligand binding activity; cell viability; cell growth on soft agar; anchorage dependence; contact inhibition and density limitation of growth; cellular proliferation; cellular transformation; growth factor or serum dependence; tumor specific marker levels; invasiveness into Matrigel; tumor growth and metastasis in vivo; mRNA and protein expression in cells undergoing

metastasis; and other characteristics of cancer cells. "Functional effects"include in vitro, in vivo, and ex vivo activities.

By"determining the functional effect"is meant assaying for a compound that increases or decreases a parameter that is indirectly or directly under the influence of a cancer protein sequence, e. g. , physiological, functional, enzymatic, physical, or chemical effects. Such functional effects can be measured, e : g., changes in spectroscopic characteristics (e. g., fluorescence, absorbance, refractive index), hydrodynamic (e. g. , shape), chromatographic, or solubility properties for the protein, measuring inducible markers or transcriptional activation of the cancer protein, measuring binding activity or binding assays, e. g. , binding to antibodies or other ligands, and measuring growth, cellular proliferation, cell viability, cellular transformation, growth factor or serum dependence, tumor specific marker levels, invasiveness into Matrigel, tumor growth and metastasis in vivo, mRNA and protein expression, and other characteristics of cancer cells. The functional effects can be evaluated by many means, e. g., microscopy for quantitative or qualitative measures of alterations in morphological features, measurement of changes in RNA or protein levels for cancer-associated sequences, measurement of RNA stability, identification of downstream or reporter gene expression (CAT, luciferase, 0-gal, GFP, and the like), e. g. , via chemiluminescence, fluorescence, colorimetric reactions, antibody binding, inducible markers, and ligand binding assays.

"Inhibitors", "activators, "and"modulators"of cancer polynucleotide and polypeptide sequences are used to refer to activating, inhibitory, or modulating molecules or compounds identified using in vitro and in vivo assays of cancer polynucleotide and polypeptide sequences.

Inhibitors are compounds that, e. g. , bind to, partially or totally block activity, decrease, prevent, delay activation, inactivate, desensitize, or down regulate the activity or expression of cancer proteins, e. g. , antagonists. Antisense or inhibitory nucleic acids may seem to inhibit expression<BR> and subsequent function of the protein. "Activators"are compounds that increase, open, activate, facilitate, enhance activation, sensitize, agonize, or up regulate cancer protein activity.

Inhibitors, activators, or modulators also include genetically modified versions of cancer proteins, e. g. , versions with altered activity, as well as naturally occurring and synthetic ligands, antagonists, agonists, antibodies, small chemical molecules, and the like. Such assays for inhibitors and activators include, e. g. , expressing the cancer protein in vitro, in cells, or cell membranes, applying putative modulator compounds, and then determining the functional effects on activity, as described above. Activators and inhibitors of cancer can also be identified

by incubating cancer cells with the test compound and determining increases or decreases in the expression of 1 or more cancer proteins, e. g. , 1,2, 3,4, 5,10, 15,20, 25,30, 40,50, or more cancer proteins, such as cancer proteins encoded by the sequences set out in Tables 1-68.

Samples or assays comprising cancer proteins that are treated with a potential activator, inhibitor, or modulator are compared to control samples without the inhibitor, activator, or modulator to examine the extent of inhibition. Control samples (untreated with inhibitors) are assigned a relative protein activity value of 100%. Inhibition of a polypeptide is achieved when the activity value relative to the control is about 80%, preferably 50%, more preferably 25-0%.

Activation of a cancer polypeptide is achieved when the activity value relative to the control (untreated with activators) is 110%, more preferably 150%, more preferably 200-500% (e. g., two to five fold higher relative to the control), more preferably 1000-3000% higher.

The phrase"changes in cell growth"refers to any change in cell growth and proliferation characteristics in vitro or in vivo, such as cell viability, formation of foci, anchorage independence, semi-solid or soft agar growth, changes in contact inhibition and density limitation of growth, loss of growth factor or serum requirements, changes in cell morphology, gaining or losing immortalization, gaining or losing tumor specific markers, ability to form or suppress tumors when injected into suitable animal hosts, and/or immortalization of the cell. <BR> <BR> <P>See, e. g. , pp. 231-241 in Freshney (1994) Culture of Animal Cells a Manual of Basic Technique<BR> (2d ed. ) Wiley-Liss.

"Tumor cell"refers to precancerous, cancerous, and normal cells in a tumor.

"Cancer cells,""transformed"cells or"transformation"in tissue culture, refers to spontaneous or induced phenotypic changes that do not necessarily involve the uptake of new genetic material. Although transformation can arise from infection with a transforming virus and incorporation of new genomic DNA, or uptake of exogenous DNA, it can also arise spontaneously or following exposure to a carcinogen, thereby mutating an endogenous gene.

Transformation is associated with phenotypic changes, such as immortalization of cells, aberrant growth control, nonmorphological changes, and/or malignancy. See, Freshney (2000) Culture of Animal Cells: A Manual of Basic Technique (4th ed. ) Wiley-Liss.

"Antibody"refers to a polypeptide comprising a framework region from an immunoglobulin gene or fragments thereof that specifically binds and recognizes an antigen.

The recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon, and mu constant region genes, as well as the myriad immunoglobulin variable region genes.

Light chains are classified as either kappa or lambda. Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, IgA, IgD, and IgE, respectively. Typically, the antigen-binding region of an antibody or its functional equivalent will be most critical in specificity and affinity of binding. See Paul (ed.

1999) Fundamental Immunology (4th ed. ) Raven.

An exemplary immunoglobulin (antibody) structural unit comprises a tetramer. Each tetramer is composed of two identical pairs of polypeptide chains, each pair having one"light" (about 25 kD) and one"heavy"chain (about 50-70 kD). The N-terminus of each chain defines a variable region of about 100 to 110 or more amino acids primarily responsible for antigen recognition. The terms variable light chain (VL) and variable heavy chain (VH) refer to these light and heavy chains respectively. <BR> <BR> <P>Antibodies exist, e. g. , as intact immunoglobulins or as a number of well-characterized<BR> fragments produced by digestion with various peptidases. Thus, e. g. , pepsin digests an antibody below the disulfide linkages in the hinge region to produce F (ab)'2 a dimer of Fab which itself is a light chain joined to VH-CH1 by a disulfide bond. The F (ab)'2 may be reduced under mild conditions to break the disulfide linkage in the hinge region, thereby converting the F (ab)'2 dimer into an Fab'monomer. The Fab'monomer is essentially Fab with part of the hinge region (see Paul (ed. 1999) Fundamental Immunology (4th ed. ) Raven. While various antibody fragments are defined in terms of the digestion of an intact antibody, one of skill will appreciate that such fragments may be synthesized de novo either chemically or by using recombinant DNA methodology. Thus, the term antibody, as used herein, also includes antibody fragments either produced by the modification of whole antibodies, or those synthesized de novo using recombinant DNA methodologies (e. g. , single chain Fv) or those identified using phage display<BR> libraries (see, e. g. , McCafferty, et al. (1990) Nature 348 : 552-554).<BR> <P>For preparation of antibodies, e. g. , recombinant, monoclonal, or polyclonal antibodies,<BR> many techniques known. See, e. g. , Kohler and Milstein (1975) Nature 256: 495-497 ; Kozbor, et al. (1983) Immunology Today 4: 72 ; Cole, et al. (1985) pp. 77-96 in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; Coligan (1991) Current Protocols in Immunology Lippincott; Harlow and Lane (1988) Antibodies: A Laboratory Manual CSH <BR> <BR> Press; and Goding (1986) Monoclonal Antibodies: Principles and Practice (2d ed. ) Academic Press. Techniques for the production of single chain antibodies (U. S. Patent 4,946, 778) can be adapted to produce antibodies to polypeptides of this invention. Also, transgenic mice, or other

organisms such as other mammals, may be used to express humanized antibodies.

Alternatively, phage display technology can be used to identify antibodies and heteromeric Fab <BR> <BR> fragments that specifically bind to selected antigens. See, e. g. , McCafferty, et al. (1990) Nature 348: 552-554; Marks, et al. (1992) Biotechnology 10: 779-783.

A"chimeric antibody"is an antibody molecule in which (a) the constant region, or a portion thereof, is altered, replaced, or exchanged so that the antigen binding site (variable region) is linked to a constant region of a different or altered class, effector function, and/or species, or an entirely different molecule which confers new properties to the chimeric antibody, e. g. , an enzyme, toxin, hormone, growth factor, drug, etc.; or (b) the variable region, or a portion thereof, is altered, replaced, or exchanged with a variable region having a different or altered antigen specificity.

Identification of cancer-associated sequences In one aspect, the expression levels of genes are determined in different patient samples for which diagnosis information is desired, to provide expression profiles. An expression profile of a particular sample is essentially a"fingerprint"of the state of the sample; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is characteristic of the state of the cell. That is, normal tissue may be distinguished from cancerous or metastatic cancerous tissue, or cancer tissue or metastatic cancerous tissue can be compared with tissue from surviving cancer patients. By comparing expression profiles of tissue in known different cancer states, information regarding which genes are important (including both up-and down- regulation of genes) in each of these states is obtained. Molecular profiling may distinguish subtypes of a currently collective disease designation, e. g. , different forms of a cancer.

The identification of sequences that are differentially expressed in cancer versus non- cancer tissue allows the use of this information in a number of ways. For example, a particular treatment regime may be evaluated: does a chemotherapeutic drug act to down-regulate cancer, and thus tumor growth or recurrence, in a particular patient. Alternatively, a treatment step may induce other markers which may be used as targets to destroy tumor cells. Similarly, diagnosis and treatment outcomes may be done or confirmed by comparing patient samples with the known expression profiles. Maliganant disease may be compared to non-malignant conditions.

Metastatic tissue can also be analyzed to determine the stage of cancer in the tissue, or origin of <BR> <BR> primary tumor, e. g. , metastasis from a remote primary site. Furthermore, these gene expression

profiles (or individual genes) allow screening of drug candidates with an eye to mimicking or <BR> <BR> altering a particular expression profile; e. g. , screening can be done for drugs that suppress the cancer expression profile. This may be done by making biochips comprising sets of the important cancer genes, which can then be used in these screens. These methods can also be done on the protein basis; that is, protein expression levels of the cancer proteins can be evaluated for diagnostic purposes or to screen candidate agents. In addition, the cancer nucleic acid sequences can be administered for gene therapy purposes, including the administration of antisense nucleic acids, or the cancer proteins (including antibodies and other modulators thereof) administered as therapeutic drugs.

Thus the present invention provides nucleic acid and protein sequences that are differentially expressed in cancer relative to normal tissues and/or non-malignant disease, or in different types of related diseases, herein termed"cancer sequences."As outlined below, cancer <BR> <BR> sequences include those that are up-regulated (e. g. , expressed at a higher level) in cancer, as<BR> well as those that are down-regulated (e. g. , expressed at a lower level). In a preferred embodiment, the cancer sequences are from humans; however, cancer sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other cancer sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, <BR> <BR> hamsters, guinea pigs, etc. ), primates, farm animals (including sheep, goats, pigs, cows, horses,<BR> etc. ) and pets (e. g. , dogs, cats, etc. ). Cancer sequences from other organisms may be obtained using the techniques outlined below.

Cancer sequences can include both nucleic acid and amino acid sequences. In a preferred embodiment, the skin cancer sequences are recombinant nucleic acids. These nucleic acid sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids, as well as screening applications; e. g. , biochips comprising nucleic acid probes or PCR microtiter plates with selected probes to the cancer sequences.

A cancer sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, e. g. , using homology programs or hybridization conditions.

For identifying cancer-associated sequences, the cancer screen typically includes <BR> <BR> comparing genes identified in different tissues, e. g. , normal and cancerous tissues, cancer and

non-malignant conditions, non-malignant conditions and normal tissues, or tumor tissue samples from patients who have metastatic disease vs. non metastatic tissue. Other suitable tissue comparisons include comparing cancer samples with metastatic cancer samples from other cancers, such as lung, stomach, gastrointestinal cancers, etc. Samples of different stages of cancer, e. g. , survivor tissue, drug resistant states, and tissue undergoing metastasis, are applied to biochips comprising nucleic acid probes. The samples are first microdissected, if applicable, and treated for preparation of mRNA. Suitable biochips are commercially available, e. g. , from Affymetrix, Santa Clara, CA. Gene expression profiles as described herein are generated and the data analyzed.

In one embodiment, the genes showing changes in expression as between normal and disease states are compared to genes expressed in other normal tissues, including, and not limited to lung, heart, brain, liver, stomach, kidney, muscle, colon, small intestine, large intestine, spleen, bone, and/or placenta. In a preferred embodiment, those genes identified during the cancer screen that are expressed in a significant amount in other tissues (e. g., essential organs) are removed from the profile, although in some embodiments, this is not <BR> <BR> necessary (e. g. , where organs may be dispensible, e. g. , female or male specific). That is, when screening for drugs, it is usually preferable that the target expression be disease specific, to minimize possible side effects on other organs were there expression.

In a preferred embodiment, cancer sequences are those that are up-regulated in cancer; that is, the expression of these genes is higher in the cancer tissue as compared to non-cancer or non-malignant tissue. "Up-regulation"as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being preferred. Another embodiment is directed to sequences up-regulated in non-malignant conditions relative to normal. Uniformity among relevant samples is also preferred.

Unigene cluster identification numbers and accession numbers herein are for the GenBank sequence database and the sequences of the accession numbers are hereby expressly incorporated by reference. GenBank is available, see, e. g. , Benson, et al. (1998) Nuc. Acids Res. 26: 1-7; and http://www. ncbi. nlm. nih. gov/. Sequences are also available in other databases, e. g. , European Molecular Biology Laboratory (EMBL) and DNA Database of Japan (DDBJ).

In some situations, the sequences may be derived from assembly of available sequences or be predicted from genomic DNA using exon prediction algorithms, such as FGENESH. See

Salamov and Solovyev (2000) Genome Res. 10: 516-522. In other situations, sequences have been derived from cloning and sequencing of isolated nucleic acids.

In another preferred embodiment, cancer sequences are those that are down-regulated in the cancer; that is, the expression of these genes is lower in cancer tissue as compared to non- cancerous tissue. "Down-regulation"as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being preferred.

Informatics The ability to identify genes that are over or under expressed in cancer can additionally provide high-resolution, high-sensitivity datasets which can be used in the areas of diagnostics, therapeutics, drug development, pharmacogenetics, protein structure, biosensor development, and other related areas. For example, the expression profiles can be used in diagnostic or prognostic evaluation of patients with cancer or related diseases. See Tables 1 and 3. Or as another example, subcellular toxicological information can be generated to better direct drug structure and activity correlation (see Anderson (June 11-12,1998) Pharmaceutical Proteomics: Targets, Mechanism, and Function, paper presented at the IBC Proteomics conference, Coronado, CA). Subcellular toxicological information can also be utilized in a biological sensor device to predict the likely toxicological effect of chemical exposures and likely tolerable exposure thresholds (see U. S. Patent No. 5,811, 231). Similar advantages accrue from datasets relevant to other biomolecules and bioactive agents (e. g. , nucleic acids, saccharides, lipids, drugs, and the like).

Thus, in another embodiment, the present invention provides a database that includes at least one set of assay data. The data contained in the database is acquired, e. g. , using array analysis either singly or in a library format. The database can be in a form in which data can be maintained and transmitted, but is preferably an electronic database. The electronic database of the invention can be maintained on any electronic device allowing for the storage of and access to the database, such as a personal computer, but is preferably distributed on a wide area network, such as the World Wide Web.

The focus of the present section on databases that include peptide sequence data is for clarity of illustration only. Similar databases can be assembled for assay data acquired using an assay of the invention.

The compositions and methods for identifying and/or quantitating the relative and/or absolute abundance of a variety of molecular and macromolecular species from a biological sample representing cancer, e. g. , the identification of cancer-associated sequences described herein, provide an abundance of information which can be correlated with pathological conditions, predisposition to disease, drug testing, therapeutic monitoring, gene-disease causal linkages, identification of correlates of immunity and physiological status, among others.

Although the data generated from the assays of the invention is suited for manual review and analysis, in a preferred embodiment, data processing using high-speed computers is utilized.

An array of methods for indexing and retrieving biomolecular information is available.

For example, U. S. Patents 6,023, 659 and 5,966, 712 disclose a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. U. S. Patent 5,953, 727 discloses a relational database having sequence records containing information in a format that allows a collection of partial-length DNA sequences to be catalogued and searched according to association with one or more sequencing projects for obtaining full-length sequences from the collection of partial length sequences. U. S. Patent 5,706, 498 discloses a gene database retrieval system for making a retrieval of a gene sequence similar to a sequence data item in a gene database based on the degree of similarity between a key sequence and a target sequence. U. S.

Patent 5,538, 897 discloses a method using mass spectroscopy fragmentation patterns of peptides to identify amino acid sequences in computer databases by comparison of predicted mass spectra with experimentally-derived mass spectra using a closeness-of-fit measure. U. S.

Patent 5,926, 818 discloses a multi-dimensional database comprising a functionality for multi- dimensional data analysis described as on-line analytical processing (OLAP), which entails the consolidation of projected and actual data according to more than one consolidation path or dimension. U. S. Patent 5,295, 261 reports a hybrid database structure in which the fields of each database record are divided into two classes, navigational and informational data, with navigational fields stored in a hierarchical topological map which can be viewed as a tree structure or as the merger of two or more such tree structures. See also Baxevanis, et al. (2001) Bioinformatics : A Practical Guuide to the Analysis of Genes and Proteins Wiley; Mount (2001) Bioinformatics : Sequence and Genome Analysis CSH Press, NY ; Durbin, et al. (eds. 1999) Biological Sequence Analysis : Probabilistic Models of Proteins and Nucleic Acids Cambridge University Press; Baxevanis and Oeullette (eds. 1998) Bioinformatics : A Practical Guide to the

Analysis of Genes and Proteins (2d. ed. ) Wiley-Liss; Rashidi and Buehler (1999) Bioinformatics : Basic Applications in Biological Science and Medicine CRC Press; Setubal, et al. (eds. 1997) Introduction to Computational Molecular Biology Brooks/Cole; Misener and Krawetz (eds. 2000) Bioinformatics : Methods and Protocols Humana Press; Higgins and Taylor (eds. 2000) Bioinformatics : Sequence, Structure, and Databanks: A Practical Approach Oxford University Press; Brown (2001) Bioinformatics : A Biologist's Guide to Biocomputing and the Internet Eaton Pub.; Han and Kamber (2000) Data Mining : Concepts and Techniques Kaufmann Pub.; and Waterman (1995) Introduction to Computational Biology : Maps, Sequences, and Genomes Chap and Hall.

The present invention provides a computer database comprising a computer and <BR> <BR> software for storing in computer-retrievable form assay data records cross-tabulated, e. g. , with data specifying the source of the target-containing sample from which each sequence specificity record was obtained.

In an exemplary embodiment, at least one of the sources of target-containing sample is from a control tissue sample known to be free of pathological disorders. In a variation, at least <BR> <BR> one of the sources is a known pathological tissue specimen, e. g. , a neoplastic lesion or another tissue specimen to be analyzed for cancer. In another variation, the assay records cross-tabulate one or more of the following parameters for each target species in a sample: (1) a unique <BR> <BR> identification code, which can include, e. g. , a target molecular structure and/or characteristic<BR> separation coordinate (e. g. , electrophoretic coordinates); (2) sample source; and (3) absolute and/or relative quantity of the target species present in the sample.

The invention also provides for the storage and retrieval of a collection of target data in a computer data storage apparatus, which can include magnetic disks, optical disks, magneto- optical disks, DRAM, SRAM, SGRAM, SDRAM, RDRAM, DDR RAM, magnetic bubble memory devices, and other data storage devices, including CPU registers and on-CPU data storage arrays. Typically, the target data records are stored as a bit pattern in an array of magnetic domains on a magnetizable medium or as an array of charge states or transistor gate <BR> <BR> states, such as an array of cells in a DRAM device (e. g. , each cell comprised of a transistor and a charge storage area, which may be on the transistor). In one embodiment, the invention provides such storage devices, and computer systems built therewith, comprising a bit pattern encoding a protein expression fingerprint record comprising unique identifiers for at least 10 target data records cross-tabulated with target source.

When the target is a peptide or nucleic acid, the invention preferably provides a method for identifying related peptide or nucleic acid sequences, comprising performing a computerized comparison between a peptide or nucleic acid sequence assay record stored in or retrieved from a computer storage device or database and at least one other sequence. The comparison can include a sequence analysis or comparison algorithm or computer program embodiment thereof <BR> <BR> (e. g. , FASTA, TFASTA, GAP, BESTFIT) and/or the comparison may be of the relative amount of a peptide or nucleic acid sequence in a pool of sequences determined from a polypeptide or nucleic acid sample of a specimen.

The invention also preferably provides a magnetic disk, such as an IBM-compatible <BR> <BR> (DOS, Windows, Windows95/98/2000, Windows NT, OS/2) or other format (e. g. , Linux,<BR> SunOS, Solaris, AIX, SCO Unix, VMS, MV, Macintosh, etc. ) floppy diskette or hard (fixed, Winchester) disk drive, comprising a bit pattern encoding data from an assay of the invention in a file format suitable for retrieval and processing in a computerized sequence analysis, comparison, or relative quantitation method.

The invention also provides a network, comprising a plurality of computing devices linked via a data link, such as an Ethernet cable (coax or lOBaseT), telephone line, ISDN line, wireless network, optical fiber, or other suitable signal transmission medium, whereby at least <BR> <BR> one network device (e. g. , computer, disk array, etc. ) comprises a pattern of magnetic domains<BR> (e. g. , magnetic disk) and/or charge domains (e. g. , an array of DRAM cells) composing a bit pattern encoding data acquired from an assay of the invention.

The invention also provides a method for transmitting assay data that includes generating an electronic signal on an electronic communications device, such as a modem, ISDN terminal adapter, DSL, cable modem, ATM switch, or the like, wherein the signal includes (in native or encrypted format) a bit pattern encoding data from an assay or a database comprising a plurality of assay results obtained by the method of the invention.

In a preferred embodiment, the invention provides a computer system for comparing a query target to a database containing an array of data structures, such as an assay result obtained by the method of the invention, and ranking database targets based on the degree of identity and gap weight to the target data. A central processor is preferably initialized to load and execute the computer program for alignment and/or comparison of the assay results. Data for a query target is entered into the central processor via an I/O device. Execution of the computer

program results in the central processor retrieving the assay data from the data file, which comprises a binary description of an assay result.

The target data or record and the computer program can be transferred to secondary memory, which is typically random access memory (e. g., DRAM, SRAM, SGRAM, or SDRAM). Targets are ranked according to the degree of correspondence between a selected assay characteristic (e. g. , binding to a selected affinity moiety) and the same characteristic of the query target and results are output via an VO device. For example, a central processor can be a conventional computer (e. g., Intel Pentium, PowerPC, Alpha, PA-8000, SPARC, MIPS <BR> <BR> 4400, MIPS 10000, VAX, etc. ) ; a program can be a commercial or public domain molecular<BR> biology software package (e. g. , UWGCG Sequence Analysis Software, Darwin); a data file can<BR> be an optical or magnetic disk, a data server, a memory device (e. g. , DRAM, SRAM, SGRAM,<BR> SDRAM, EPROM, bubble memory, flash memory, etc. ); an I/O device can be a terminal comprising a video display and a keyboard, a modem, an ISDN terminal adapter, an Ethernet port, a punched card reader, a magnetic strip reader, or other suitable I/O device.

The invention also preferably provides the use of a computer system, such as that described above, which comprises: (1) a computer; (2) a stored bit pattern encoding a collection of peptide sequence specificity records obtained by the methods of the invention, which may be stored in the computer; (3) a comparison target, such as a query target; and (4) a program for alignment and comparison, typically with rank-ordering of comparison results on the basis of computed similarity values. See, e. g. , Ewens and Grant (2001) Statistical Methods in Bioinformatics : An Introduction Springer-Verlag. Mathematical approaches can also be used to conclude whether similarities or differences in the gene expression exhibited by different <BR> <BR> samples are significant. See, e. g. , Golub, et al. (1999) Science 286: 531-537 ; Duda, et al. (2001) Pattern Classification Wiley; and Hastie, et al. (2001) The Elements of Statistical Learning : Data Mining. Inference, and Prediction Springer-Verlag. One approach to determine whether a sample is more similar to or has maximum similarity with a given condition between the sample and one or more pools representing different conditions for comparison; the pool with the smallest vector angle is then chosen as the most similar to the biological sample among the pools compared.

Characteristics of cancer-associated proteins Cancer proteins of the present invention may be classified as secreted proteins, transmembrane proteins, or intracellular proteins. In one embodiment, the cancer protein is an

intracellular protein. Intracellular proteins may be found in the cytoplasm and/or in the nucleus.

Intracellular proteins are involved in all aspects of cellular function and replication (including, <BR> <BR> e. g. , signaling pathways) ; aberrant expression of such proteins often results in unregulated or<BR> disregulated cellular processes (see, e. g. , Alberts, et al. (eds. 1994) Molecular Biology of the<BR> Cell (3d ed. ) Garland). For example, many intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity, and the like. Intracellular proteins also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are involved in maintaining the structural integrity of organelles.

An increasingly appreciated concept in characterizing proteins is the presence in the proteins of one or more structural motifs for which defined functions have been attributed. In addition to the highly conserved sequences found in the enzymatic domain of proteins, highly conserved sequences have been identified in proteins that are involved in protein-protein interaction. For example, Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in a sequence dependent manner. PTB domains, which are distinct from SH2 domains, also bind tyrosine phosphorylated targets. SH3 domains bind to proline-rich targets. In addition, PH domains, tetratricopeptide repeats and WD domains to name only a few, have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phospholipids or other second messengers. These motifs can be identified on the basis of amino acid sequence; thus, an analysis of the sequence of proteins may provide insight into both the enzymatic potential of the molecule and/or molecules with which the protein may associate.

One useful database is Pfam (protein families), which is a large collection of multiple sequence alignments and hidden Markov models covering many common protein domains. Versions are available via the internet from Washington University in St. Louis, the Sanger Center in <BR> <BR> England, and the Karolinska Institute in Sweden. See, e. g. , Bateman, et al. (2000) Nuc. Acids Res. 28: 263-266; Sonnhammer, et al. (1997) Proteins 28: 405-420; Bateman, et al. (1999) Nuc.

Acids Res. 27: 260-262; and Sonnhammer, et al. (1998) Nuc. Acids Res. 26: 320-322.

In another embodiment, the cancer sequences are transmembrane proteins.

Transmembrane proteins are molecules that span a phospholipid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both. The intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins. For example, the intracellular domain may have enzymatic activity

and/or may serve as a binding site for additional proteins. Frequently the intracellular domain of transmembrane proteins serves both roles. For example certain receptor tyrosine kinases have both protein kinase activity and SH2 domains. In addition, autophosphorylation of tyrosines on the receptor molecule itself, creates binding sites for additional SH2 domain containing proteins.

Transmembrane proteins may contain from one to many transmembrane domains. For example, receptor tyrosine kinases, certain cytokine receptors, receptor guanylyl cyclases and receptor serine/threonine protein kinases contain a single transmembrane domain. However, various other proteins including channels and adenylyl cyclases contain numerous transmembrane domains. Many important cell surface receptors such as G protein coupled receptors (GPCRs) are classified as"seven transmembrane domain"proteins, as they contain 7 membrane spanning regions. Characteristics of transmembrane domains include approximately 17 consecutive hydrophobic amino acids that may be followed by charged amino acids.

Therefore, upon analysis of the amino acid sequence of a particular protein, the localization and <BR> <BR> number of transmembrane domains within the protein may be predicted (see, e. g. , PSORT web site http://psort. nibb. acjp/). Important transmembrane protein receptors include, but are not limited to the insulin receptor, insulin-like growth factor receptor, human growth hormone receptor, glucose transporters, transferrin receptor, epidermal growth factor receptor, low density lipoprotein receptor, epidermal growth factor receptor, leptin receptor, and interleukin receptors, e. g. , IL-1 receptor, IL-2 receptor, etc.

The extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. Conserved structure and/or functions have been ascribed to different extracellular motifs. Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are found on receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF, and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, neurotrophic factors, and the like. Extracellular domains also bind to cell-associated molecules. In this respect, they may mediate cell-cell interactions. Cell-associated ligands can <BR> <BR> be tethered to the cell, e. g. , via a glycosylphosphatidylinositol (GPI) anchor, or may themselves

be transmembrane proteins. Extracellular domains may also associate with the extracellular matrix and contribute to the maintenance of the cell structure.

Cancer proteins that are transmembrane are particularly preferred in the present invention as they are readily accessible targets for immunotherapeutics, as are described herein.

In addition, as outlined below, transmembrane proteins can be also useful in imaging modalities. Antibodies may be used to label such readily accessible proteins in situ.

Alternatively, antibodies can also label intracellular proteins, in which case samples are typically permeablized to provide access to intracellular proteins. In addition, some membrane proteins can be processed to release a soluble protein, or to expose a residual fragment.

Released soluble proteins may be useful diagnostic markers, processed residual protein fragments may be useful lung markers of disease.

It will also be appreciated that a transmembrane protein can be made soluble by removing transmembrane sequences, e. g. , through recombinant methods. Furthermore, transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence.

In another embodiment, the cancer proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins may have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; e. g. , if circulating, they often serve to transmit signals to various other cell types. The secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor), an endocrine manner (acting on cells at a distance, e. g, secretion into the blood stream), or exocrine (secretion, e. g. , through a duct or to adjacent epithelial surface as sweat glands, sebaceous glands, pancreatic ducts, lacrimal glands, mammary glands, <BR> <BR> wax producing glands of the ear, etc. ). Thus secreted molecules often find use in modulating or altering numerous aspects of physiology. Cancer proteins that are secreted proteins are particularly preferred in the present invention as they serve as good targets for diagnostic <BR> <BR> markers, e. g. , for blood, plasma, serum, or stool tests. Those which are enzymes may be<BR> antibody or small molecule targets. Others may be useful as vaccine targets, e. g. , via CTL mechanisms.

Use of cancer nucleic acids As described above, cancer sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology or linkage to the cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.

Typically, linked sequences on a mRNA are found on the same molecule.

As detailed elsewhere, percent identity can be determined using an algorithm such as BLAST. A preferred method utilizes the BLASTN module of WU-BLAST-2 set to the default parameters, with overlap span and overlap fraction set to 1 and 0.125, respectively. Alignment may include the introduction of gaps in the sequences to be aligned. In addition, for sequences which contain either more or fewer nucleotides than those of the nucleic acids described, the percentage of homology may be determined based on the number of homologous nucleosides in relation to the total number of nucleosides. Thus, e. g. , homology of sequences shorter than those of the sequences identified will be determined using the number of nucleosides in the shorter sequence.

In one embodiment, the nucleic acid homology is determined through hybridization studies. Thus, e. g. , nucleic acids which hybridize under high stringency to a described nucleic acid, or its complement, or is also found on naturally occurring mRNAs is considered a cancer sequence. In another embodiment, less stringent hybridization conditions are used; e. g., moderate or low stringency conditions may be used; see Ausubel, supra, and Tijssen, supra.

The cancer nucleic acid sequences of the invention, e. g. , the sequences in Tables 1-68,<BR> can be fragments of larger genes, e. g. , they are nucleic acid segments. "Genes"in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions.

Accordingly, using the sequences provided herein, extended sequences, in either direction, of the cancer genes can be obtained, using techniques well known for cloning either longer sequences or the full length sequences; see Ausubel, et al. , supra. Much can be done by informatics and many sequences can be clustered to include multiple sequences corresponding to a single gene, e. g. , systems such as UniGene (see, http://www. ncbi. nlm. nih. gov/UniGene/).

Once a cancer nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire cancer nucleic acid coding regions or the entire mRNA sequence. Once isolated from its natural source, e. g. , contained within a plasmid or other vector or excised therefrom as a linear nucleic acid segment, the recombinant cancer nucleic acid can

be further used as a probe to identify and isolate other cancer nucleic acids, e. g. , extended coding regions. It can also be used as a"precursor"nucleic acid to make modified or variant cancer nucleic acids and proteins.

The cancer nucleic acids of the present invention are used in several ways. In one embodiment, nucleic acid probes to the cancer nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, as outlined below, or for administration, e. g., for gene therapy, vaccine, RNAi, and/or antisense applications. Alternatively, cancer nucleic acids that include coding regions of cancer proteins can be put into expression vectors for the expression of cancer proteins, again for screening purposes or for administration to a patient.

In a preferred embodiment, nucleic acid probes to cancer nucleic acids (both the nucleic acid sequences outlined in the figures and/or the complements thereof) are made. The nucleic acid probes attached to the biochip are designed to be substantially complementary to the cancer <BR> <BR> nucleic acids, e. g. , the target sequence (either the target sequence of the sample or to other<BR> probe sequences, e. g. , in sandwich assays), such that hybridization of the target sequence and the probes of the present invention occurs. As outlined below, this complementarity need not be perfect; there may be any number of base pair mismatches which will interfere with hybridization between the target sequence and the single stranded nucleic acids of the present invention. However, if the number of mutations is so great that no hybridization can occur under even the least stringent of hybridization conditions, the sequence is not a complementary target sequence. Thus, by"substantially complementary"herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under normal reaction conditions, particularly high stringency conditions, as outlined herein.

A nucleic acid probe is generally single stranded but can be partially single and partially double stranded. The strandedness of the probe is dictated by the structure, composition, and properties of the target sequence. In general, ~the nucleic acid probes range from about 8-100 bases long, with from about 10-80 bases being preferred, and from about 30-50 bases being particularly preferred. That is, generally whole genes are not used. In some embodiments, much longer nucleic acids can be used, up to hundreds of bases.

In a preferred embodiment, more than one probe per sequence is used, with either overlapping probes or probes to different sections of the target being used. That is, two, three, four or more probes, with three being preferred, are used to build in a redundancy for a

particular target. The probes can be overlapping (e. g. , have some sequence in common), or separate. In some cases, PCR primers may be used to amplify signal for higher sensitivity.

Nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By"immobilized"and grammatical equivalents herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal as outlined. The binding can typically be covalent or non-covalent. By"non-covalent binding"and grammatical equivalents herein is meant one or more of electrostatic, hydrophilic, and hydrophobic interactions. Included in non- <BR> <BR> covalent binding is the covalent attachment of a molecule, e. g. , streptavidin to the support and the non-covalent binding of the biotinylated probe to the streptavidin. By"covalent binding" and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds, and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.

In general, the probes are attached to the biochip in a wide variety of ways. As described herein, the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip.

The biochip comprises a suitable solid substrate. By"substrate"or"solid support"or other grammatical equivalents herein is meant a material that can be modified for the attachment or association of the nucleic acid probes and is amenable to at least one detection method. Often, the substrate may contain discrete individual sites appropriate for individual partitioning and identification. The number of possible substrates is very large, and include, but are not limited to, glass and modified or functionalized glass, plastics (including acrylics, polystyrene and copolymers of styrene and other materials, polypropylene, polyethylene, polybutylene, polyurethanes, TeflonJ, etc. ), polysaccharides, nylon or nitrocellulose, resins, silica or silica-based materials including silicon and modified silicon, carbon, metals, inorganic glasses, plastics, etc. In general, the substrates allow optical detection and do not appreciably fluoresce. See WO 0055627.

Generally the substrate is planar, although other configurations of substrates may be used as well. For example, the probes may be placed on the inside surface of a tube for flow-

through sample analysis to minimize sample volume. Similarly, the substrate may be flexible, such as a flexible foam, including closed cell foams made of particular plastics.

In a preferred embodiment, the surface of the biochip and the probe may be derivatized with chemical functional groups for subsequent attachment of the two. Thus, e. g. , the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxy groups, oxo groups, and thiol groups, with amino groups being particularly preferred.

Using these functional groups, the probes can be attached using functional groups on the probes.

For example, nucleic acids containing amino groups can be attached to surfaces comprising amino groups, e. g. , using linkers; e. g. , homo-or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155- 200). In addition, in some cases, additional linkers, such as alkyl groups (including substituted and heteroalkyl groups) may be used.

In this embodiment, oligonucleotides are synthesized, and then attached to the surface of the solid support. Either the 5'or 3'terminus may be attached to the solid support, or attachment may be via linkage to an internal nucleoside. In another embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.

Alternatively, the oligonucleotides may be synthesized on the surface. For example, photoactivation techniques utilizing photopolymerization compounds and techniques are used.

In a preferred embodiment, the nucleic acids can be synthesized in situ, using known photolithographic techniques, such as those described in WO 95/25116; WO 95/35505; U. S.

Patent Nos. 5,700, 637 and 5,445, 934; and references cited within, all of which are expressly incorporated by reference; these methods of attachment form the basis of the Affymetrix GeneChipTM technology.

Often, amplification-based assays are performed to measure the expression level of cancer-associated sequences. These assays are typically performed in conjunction with reverse transcription. In such assays, a cancer-associated nucleic acid sequence acts as a template in an amplification reaction (e. g. , Polymerase Chain Reaction, or PCR). In a quantitative amplification, the amount of amplification product will be proportional to the amount of template in the original sample. Comparison to appropriate controls provides a measure of the amount of cancer-associated RNA. Methods of quantitative amplification are well known.

Detailed protocols for quantitative PCR are provided, e. g. , in Innis, et al. (1990) PCR Protocols A Guide to Methods and Applications Academic Press.

In some embodiments, a TaqMan based assay is used to measure expression. TaqMan based assays use a fluorogenic oligonucleotide probe that contains a 5'fluorescent dye and a 3' quenching agent. The probe hybridizes to a PCR product, but cannot itself be extended due to a blocking agent at the 3'end. When the PCR product is amplified in subsequent cycles, the 5' nuclease activity of the polymerase, e. g. , AmpliTaq, results in the cleavage of the TaqMan probe. This cleavage separates the 5'fluorescent dye and the 3'quenching agent, thereby <BR> <BR> resulting in an increase in fluorescence as a function of amplification (see, e. g. , literature<BR> provided by Perkin-Elmer, e. g. , www2. perkin-elmer. com).

Other suitable amplification methods include, but are not limited to, ligase chain reaction (LCR) (see Wu and Wallace (1989) Genomics 4: 560-569, Landegren, et al. (1988) Science 241: 1077-1080, and Barringer, et al. (1990) Gene 89: 117-122), transcription amplification (Kwoh, et al. (1989) Proc. Natl. Acad. Sci. USA 86: 1173-1177), self-sustained sequence replication (Guatelli, et al. (1990) Proc. Nat. Acad. Sci. USA 87: 1874-1878), dot PCR, linker adapter PCR, etc.

Expression of cancer proteins from nucleic acids In a preferred embodiment, cancer nucleic acids, e. g. , encoding cancer proteins, are used to make a variety of expression vectors to express cancer proteins which can then be used in screening assays, as described below. Expression vectors and recombinant DNA technology are <BR> <BR> well known (see, e. g. , Ausubel, supra, and Fernandez and Hoeffler (eds. 1999) Gene Expression Systems Academic Press) to express proteins. The expression vectors may be either self- replicating extrachromosomal vectors or vectors which integrate into a host genome. Generally, these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the cancer protein. The term"control sequences" refers to DNA sequences used for the expression of an operably linked coding sequence in a particular host organism. Control sequences that are suitable for prokaryotes, e. g. , include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.

Nucleic acid is"operably linked"when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in

the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, "operably linked" means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous.

Linking is typically accomplished by ligation at convenient restriction sites. If such sites do not exist, synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. Transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the cancer protein. Numerous types of appropriate expression vectors and suitable regulatory sequences are known for a variety of host cells.

In general, transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, transcriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences. In a preferred embodiment, the regulatory sequences include a promoter and transcriptional start and stop sequences.

Promoter sequences may be either constitutive or inducible promoters. The promoters may be either naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known, and are useful in the present invention.

An expression vector may comprise additional elements. For example, the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, e. g. , in mammalian or insect cells for expression and in a prokaryotic host for cloning and amplification. Furthermore, for integrating expression vectors, the expression vector often contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences which flank the expression construct. The integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are available. See, e. g., Fernandez and Hoeffler, supra; and Kitamura, et al. (1995) Proc. Nat'1 Acad. Sci. USA 92: 9146- 9150.

In addition, in a preferred embodiment, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known and will vary with the host cell used.

The cancer proteins of the present invention are usually produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding a cancer protein, under the appropriate conditions to induce or cause expression of the cancer protein. Conditions appropriate for cancer protein expression will vary with the choice of the expression vector and the host cell, and will be easily ascertained through routine experimentation or optimization.

For example, the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation of the host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction. In addition, in some embodiments, the timing of the harvest is important. For example, the baculoviral systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield.

Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect and animal cells, including mammalian cells. Of particular interest are Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, HUVEC (human umbilical vein endothelial cells), THP1 cells (a macrophage cell line), and various other human cells and cell lines.

In a preferred embodiment, the cancer proteins are expressed in mammalian cells.

Mammalian expression systems may be used, and include retroviral and adenoviral systems.

One expression vector system is a retroviral vector system such as is generally described in PCT/US97/01019 and PCT/US97/01048. Of particular use as mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, herpes simplex virus promoter, and the CMV promoter (see, e. g., Fernandez and Hoeffler, supra). Typically, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3' to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. Examples of transcription terminator and polyadenlyation signals include those derived from SV40.

Methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, are available, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation of the polynucleotide (s) in liposomes, and direct microinjection of the DNA into nuclei.

In a preferred embodiment, cancer proteins are expressed in bacterial systems.

Promoters from bacteriophage may also be used. In addition, synthetic promoters and hybrid promoters are also useful; e. g. , the tac promoter is a hybrid of the trp and lac promoter sequences. Furthermore, a bacterial promoter can include naturally occurring promoters of non- bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription.

In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable.

The expression vector may also include a signal peptide sequence that provides for secretion of the cancer protein in bacteria. The protein is either secreted into the growth media (gram- positive bacteria) or into the periplasmic space, located between the inner and outer membrane of the cell (gram-negative bacteria). The bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed.

Suitable selection genes include genes which render the bacteria resistant to drugs such as ampicillin, chloramphenicol, erythromycin, kanamycin, neomycin, and tetracycline. Selectable markers also include biosynthetic genes, such as those in the histidine, tryptophan, and leucine biosynthetic pathways. These components are assembled into expression vectors. Expression vectors for bacteria are well known, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others (e. g., Fernandez and Hoeffler, supra). The bacterial expression vectors are transformed into bacterial host cells using techniques such as calcium chloride treatment, electroporation, and others.

In one embodiment, cancer proteins are produced in insect cells using, e. g. , expression vectors forthe transformation of insect cells, and in particular, baculovirus-based expression vectors.

In a preferred embodiment, a cancer protein is produced in yeast cells. Yeast expression systems are well known, and include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis, Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, and Yarrowia lipolytica.

The cancer protein may also be made as a fusion protein, using available techniques. <BR> <BR> <P>Thus, e. g. , for the creation of monoclonal antibodies, if the desired epitope is small, the cancer protein may be fused to a carrier protein to form an immunogen. Alternatively, the cancer protein may be made as a fusion protein to increase expression, or for other reasons. For example, when the cancer protein is a cancer peptide, the nucleic acid encoding the peptide may

be linked to other nucleic acid for expression purposes. Fusion with detection epitope tags can be made, e. g. , with FLAG, His6, myc, HA, etc.

In a preferred embodiment, the cancer protein is purified or isolated after expression.

Cancer proteins may be isolated or purified in a variety of ways depending on what other components are present in the sample and the requirements for purified product, e. g. , natural conformation or denatured. Standard purification methods include ammonium sulfate precipitations, electrophoretic, molecular, immunological, and chromatographic techniques, including ion exchange, hydrophobic, affinity, and reverse-phase HPLC chromatography, and chromatofocusing. For example, the cancer protein may be purified using a standard anti- cancer protein antibody column. Ultrafiltration and diafiltration techniques, in conjunction with protein concentration, are also useful. See, e. g. , Walsh (2002) Proteins: Biochemistry and Biotechnology Wiley; Hardin, et al. (eds. 2001) Cloning, Gene Expression and Protein Purification Oxford Univ. Press; Wilson, et al. (eds. 2000) Encyclopedia of Separation Science Academic Press; and Scopes (1993) Protein Purification Springer-Verlag. The degree of purification necessary will vary depending on the use of the cancer protein. In some instances no purification will be necessary.

Once expressed and purified if necessary, the cancer proteins and nucleic acids are useful in a number of applications. They may be used as immunoselection reagents, as vaccine reagents, as screening agents, therapeutic entities, for production of antibodies, as transcription or translation inhibitors, etc.

Variants of cancer proteins Also included within one embodiment of cancer proteins are amino acid variants of the naturally occurring sequences, as determined herein. Preferably, the variants are preferably greater than about 75% homologous to the wild-type sequence, more preferably greater than about 80%, even more preferably greater than about 85%, and most preferably greater than 90%. In some embodiments the homology will be as high as about 93-95% or 98%. As for nucleic acids, homology in this context means sequence similarity or identity, with identity being preferred. This homology will be determined using standard techniques, as are outlined above for nucleic acid homologies.

Cancer proteins of the present invention may be shorter or longer than the wild type amino acid sequences. Thus, in a preferred embodiment, included within the definition of cancer proteins are portions or fragments of the wild type sequences herein. In addition, as

outlined above, the cancer nucleic acids of the invention may be used to obtain additional coding regions, and thus additional protein sequence.

In one embodiment, the cancer proteins are derivative or variant cancer proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative cancer peptide will often contain at least one amino acid substitution, deletion, or insertion, with amino acid substitutions being particularly preferred. The amino acid substitution, insertion, or deletion may occur at many residue positions within the cancer peptide.

Also included within one embodiment of cancer proteins of the present invention are amino acid sequence variants. These variants typically fall into one or more of three classes: substitutional, insertional, or deletional variants. These variants ordinarily are prepared by site specific mutagenesis of nucleotides in the DNA encoding the cancer protein, using cassette or PCR mutagenesis or other techniques, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant cancer protein fragments having up to about 100-150 residues may be prepared by in vitro'synthesis using established techniques. Amino acid sequence variants are characterized by the predetermined nature of the variation, a feature that sets them apart from naturally occurring allelic or interspecies variation of the cancer protein amino acid sequence. The variants typically exhibit a similar qualitative biological activity as a naturally occurring analogue, although variants can also be selected which have modified characteristics.

While the site or region for introducing an amino acid sequence variation is often predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed cancer variants screened for the optimal combination of desired activity. Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, e. g., M13 primer mutagenesis and PCR mutagenesis. Screening of mutants is often done using assays of cancer protein activities.

Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1-20 amino acids, although considerably larger insertions may be tolerated. Deletions generally range from about 1-20 residues, although in some cases deletions may be much larger.

Substitutions, deletions, insertions, or combination thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the

alteration of the molecule. However, larger changes may be tolerated in certain circumstances.

When small alterations in the characteristics of the cancer protein are desired, substitutions are generally made in accordance with the amino acid substitution relationships described.

The variants typically exhibit essentially the same qualitative biological activity and will elicit the same immune response as a naturally-occurring analog, although variants also are selected to modify the characteristics of cancer proteins as needed. Alternatively, the variant may be designed such that a biological activity of the cancer protein is altered. For example, glycosylation sites may be added, altered, or removed.

Substantial changes in function or immunological identity are sometimes made by selecting substitutions that are less conservative than those described above. For example, substitutions may be made which more significantly affect: the structure of the polypeptide backbone in the area of the alteration, for example the alpha-helical or beta-sheet structure; the charge or hydrophobicity of the molecule at the target site; or the bulk of the side chain.

Substitutions which generally are expected to produce the greatest changes in the polypeptide's <BR> <BR> properties are those in which (a) a hydrophilic residue, e. g. , serine or threone is substituted for<BR> (or by) a hydrophobic residue, e. g. , leucine, isoleucine, phenylalanine, valine, or alanine; (b) a cysteine or proline is substituted for (or by) another residue; (c) a residue having an <BR> <BR> electropositive side chain, e. g. , lysine, arginine, or histidine, is substituted for (or by) an<BR> electronegative residue, e. g. , glutamic or aspartic acid; (d) a residue having a bulky side chain,<BR> e. g. , phenylalanine, is substituted for (or by) one not having a side chain, e. g. , glycine; or (e) a proline residue is incorporated or substituted, which changes the degree of rotational freedom of the peptidyl bond.

Variants typically exhibit a similar qualitative biological activity and will elicit the same immune response as the naturally-occurring analog, although variants also are selected to modify the characteristics of the skin cancer proteins as needed. Alternatively, the variant may be designed such that the biological activity of the cancer protein is altered. For example, glycosylation sites may be altered or removed.

Covalent modifications of cancer polypeptides are included within the scope of this invention. One type of covalent modification includes reacting targeted amino acid residues of a cancer polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N-or C-terminal residues of a cancer polypeptide. Derivatization with bifunctional agents is useful, for instance, for crosslinking cancer polypeptides to a water-

insoluble support matrix or surface for use in a method for purifying anti-cancer polypeptide antibodies or screening assays, as is more fully described below. Commonly used crosslinking agents include, e. g., l, l-bis (diazoacetyl) -2-phenylethane, glutaraldehyde, N-<BR> hydroxysuccinimide esters, e. g. , esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3'-dithiobis (succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-1, 8-octane and agents such as methyl-3- ( (p- azidophenyl) dithio) propioimidate.

Other modifications include deamidation of glutaminyl and asparaginyl residues to the corresponding glutamyl and aspartyl residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of serinyl, threonyl, or tyrosyl residues, methylation of the <BR> <BR> amino groups of the lysine, arginine, and histidine side chains (e. g. , pp. 79-86, Creighton (1992) Proteins: Structure and Molecular Properties Freeman), acetylation of the N-terminal amine, and amidation of a C-terminal carboxyl group.

Another type of covalent modification of the cancer polypeptide included within the scope of this invention comprises altering the native glycosylation pattern of the polypeptide.

"Altering the native glycosylation pattern"is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence cancer polypeptide, and/or adding one or more glycosylation sites that are not present in the native sequence cancer polypeptide.

Glycosylation patterns can be altered in many ways. Different cell types to express cancer- associated sequences can result in different glycosylation patterns.

Addition of glycosylation sites to cancer polypeptides may also be accomplished by <BR> <BR> altering the amino acid sequence thereof. The alteration may be made, e. g. , by the addition of, or substitution by, one or more serine or threonine residues to the native sequence cancer polypeptide (for 0-linked glycosylation sites). The cancer amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the cancer polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids.

Another means of increasing the number of carbohydrate moieties on the cancer polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. See, e. g., WO 87/05330 ; pp. 259-306 in Aplin and Wriston (1981) CRC Crit. Rev. Biochem.

Removal of carbohydrate moieties present on the cancer polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for

amino acid residues that serve as targets for glycosylation. Chemical deglycosylation <BR> <BR> techniques are applicable. See, e. g. , Sojar and Bahl (1987) Arch. Biochem. Biophys. 259: 52-57 and Edge, et al. (1981) Anal. Biochem. 118: 131-137. Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo-and exo-glycosidases.

See, e. g. , Thotakura, et al. (1987) Meth. Enzymol. 138 : 350-359.

Another type of covalent modification of cancer comprises linking the cancer polypeptide to one of a variety of nonproteinaceous polymers, e. g. , polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U. S. Patent Nos.

4,640, 835; 4,496, 689; 4,301, 144 ; 4,670, 417; 4,791, 192, or 4,179, 337.

Cancer polypeptides of the present invention may also be modified in a way to form chimeric molecules comprising a cancer polypeptide fused to another heterologous polypeptide or amino acid sequence. In one embodiment, such a chimeric molecule comprises a fusion of a cancer polypeptide with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino-or carboxyl- terminus of the cancer polypeptide. The presence of such epitope-tagged forms of a cancer polypeptide can be detected using an antibody against the tag polypeptide. Also, provision of the epitope tag enables the cancer polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. In an alternative embodiment, the chimeric molecule may comprise a fusion of a cancer polypeptide with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form of the chimeric molecule, such a fusion could-be to the Fc region of an IgG molecule.

Various tag polypeptides and their respective antibodies are available. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; HIS6 and metal chelation tags, the flu HA tag polypeptide and its antibody 12CA5 (Field, et al. (1988) Mol.

Cell. Biol. 8: 2159-2165); the c-myc tag and the 8F9,3C7, 6E10, G4, B7, and 9E10 antibodies thereto (Evan, et al. (1985) Molecular and Cellular Biology 5: 3610-3616); and the Herpes Simplex virus glycoprotein D (gD) tag and its antibody (Paborsky, et al. (1990) Protein Engineering 3 (6): 547-553). Other tag polypeptides include the Flag-peptide (Hopp, et al.

(1988) BioTechnology 6: 1204-1210); the KT3 epitope peptide (Martin, et al. (1992) Science 255: 192-194); tubulin epitope peptide (Skinner, et al. (1991) J. Biol. Chem. 266: 15163-15166); and the T7 gene 10 protein peptide tag (Lutz-Freyermuth, et al. (1990) Proc. Natl. Acad. Sci.

USA 87: 6393-6397).

Also included are other cancer proteins of the cancer family, and cancer proteins from other organisms, which are cloned and expressed as outlined below. Thus, probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related cancer proteins from humans or other organisms. Particularly useful probe and/or PCR primer sequences include the unique areas of the cancer nucleic acid sequence. Preferred PCR primers are from about 15-35 nucleotides in length, with from about 20-30 being preferred, and may contain inosine as needed. The conditions for PCR reaction have been well described (e. g., Innis, PCR Protocols, supra).

In addition, cancer proteins can be made that are longer than those encoded by the nucleic acids of the Tables, e. g. , by the elucidation of extended sequences, the addition of epitope or purification tags, the addition of other fusion sequences, etc.

Cancer proteins may also be identified as being encoded by cancer nucleic acids. Thus, cancer proteins are encoded by nucleic acids that will hybridize to the sequences of the sequence listings, or their complements, as outlined herein.

Antibodies to cancer proteins In a preferred embodiment, when the cancer protein is to be used to generate antibodies, e. g. , for immunotherapy or immunodiagnosis, the cancer protein should share at least one epitope or determinant with the full length protein. By"epitope"or"determinant"herein is typically meant a portion of a protein which will generate and/or bind an antibody or T-cell receptor in the context of MHC. Thus, in most instances, antibodies made to a smaller cancer protein will be able to bind to the full-length protein, particularly linear epitopes. In a preferred embodiment, the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity. In a preferred embodiment, the epitope is selected from a protein sequence set out in the tables. <BR> <BR> <P>Methods of preparing polyclonal antibodies exist (e. g. , Coligan, supra; and Harlow and<BR> Lane, supra). Polyclonal antibodies can be raised in a mammal, e. g. , by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections.

The immunizing agent may include a protein encoded by a nucleic acid of Tables 1-68 or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum

albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Examples of adjuvants which may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). Various immunization protocols may be used.

The antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein (1975) Nature 256: 495. In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent.

Alternatively, the lymphocytes may be immunized in vitro. The immunizing agent will typically include a polypeptide encoded by a nucleic acid of the tables or fragment thereof, or a fusion protein thereof. Generally, either peripheral blood lymphocytes ("PBLs") are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line <BR> <BR> using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (e. g. , pp.

59-103 in Goding (1986) Monoclonal Antibodies: Principles and Practice Academic Press).

Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine, or human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine ("HAT medium"), which substances prevent the growth of HGPRT-deficient cells.

In one embodiment, the antibodies are bispecific antibodies. Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens or that have binding specificities for two epitopes on the same antigen. In one embodiment, one of the binding specificities is for a protein encoded by a nucleic acid of the tables or a fragment thereof, the other one is for another antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific. Alternatively, tetramer-type technology may create multivalent reagents.

In a preferred embodiment, the antibodies to cancer protein are capable of reducing or eliminating a biological function of a cancer protein, in a naked form or conjugated to an effector moiety, as is described below. That is, the addition of anti-cancer protein antibodies (either polyclonal or preferably monoclonal) to cancer tissue (or cells containing cancer) may reduce or eliminate the cancer. Generally, at least a 25% decrease in activity, growth, size, or the like is preferred, with at least about 50% being particularly preferred and about a 95-100% decrease being especially preferred.

In a preferred embodiment the antibodies to the cancer proteins are humanized <BR> <BR> antibodies (e. g. , Xenerex Biosciences, Medarex, Inc. , Abgenix, Inc. , Protein Design Labs, Inc.)<BR> Humanized forms of non-human (e. g. , murine) antibodies are chimeric molecules of immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab', F (ab') 2 or other antigen-binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementary determining region (CDR) of the recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat, or rabbit having the desired specificity, affinity, and capacity. In some instances, Fv framework residues of a human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, a humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework (FR) regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will typically comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones, et al. (1986) Nature 321: 522-525; Riechmann, et al. (1988) Nature 332: 323-329; and Presta (1992) Curr. Op. Struct. Biol. 2: 593-596). Humanization can be essentially performed following the method of Winter and co-workers (Jones, et al. (1986) Nature 321: 522-525; Riechmann, et al. (1988) Nature 332: 323-327; Verhoeyen, et al. (1988) Science 239: 1534-1536), by substituting rodent CDRs or CDR sequences for corresponding sequences of a human antibody. Accordingly, such humanized antibodies are chimeric antibodies (U. S. Patent No. 4,816, 567), wherein substantially less than an intact human variable domain has been substituted by corresponding sequence from a non-human species.

Human antibodies can also be produced using phage display libraries (Hoogenboom and Winter (1992) J. Mol. Biol. 227: 381-388 ; Marks, et al. (1991) J. Mol. Biol. 222: 581-597) or <BR> <BR> human monoclonal antibodies (e. g. , p. 77, Cole, et al. in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; and Berner, et al. (1991) J. Immunol. 147: 86-95).

Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e. g. , mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in nearly all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, e. g. , in U. S.

Patent Nos. 5,545, 807 ; 5,545, 806; 5,569, 825; 5,625, 126; 5,633, 425; 5,661, 016, and in the following scientific publications: Marks, et al. (1992) Bio/Technology 10: 779-783 ; Lonberg, et al. (1994) Nature 368: 856-859; Morrison (1994) Nature 368: 812-13; Fishwild, et al. (1996) Nature Biotechnology 14: 845-851; Neuberger (1996) Nature Biotechnology 14: 826; and Lonberg and Huszar (1995) Intern. Rev. Immunol. 13: 65-93.

By immunotherapy is meant treatment of cancer with an antibody raised against cancer proteins. As used herein, immunotherapy can be passive or active. Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient). Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient). Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised. The antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression of the antigen, leading to an immune response.

In a preferred embodiment the cancer proteins against which antibodies are raised are secreted proteins as described above. Without being bound by theory, antibodies used for treatment may bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted cancer protein, e. g. , in autocrine signaling.

In another preferred embodiment, the cancer protein to which antibodies are raised is a transmembrane protein. Without being bound by theory, antibodies used for treatment may bind the extracellular domain of the cancer protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules. The antibody may cause down- regulation of the transmembrane cancer protein. The antibody may be a competitive, non-

competitive or uncompetitive inhibitor of protein binding to the extracellular domain of the cancer protein. The antibody may also be an antagonist of the cancer protein. Further, the antibody may prevent activation of the transmembrane cancer protein, or may induce or suppress a particular cellular pathway. In one aspect, when the antibody prevents the binding of other molecules to the cancer protein, the antibody prevents growth of the cell. The antibody may also be used to target or sensitize the cell to cytotoxic agents, including, but not limited to TNF-a, TNF-ß, IL-1, INF-y, and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like. In some instances the antibody may belong to a sub-type that activates serum complement when complexed with the transmembrane protein thereby mediating cytotoxicity or antigen-dependent cytotoxicity (ADCC). Thus, cancer may be treated by administering to a patient antibodies directed against the transmembrane cancer protein. Antibody-labeling may activate a co-toxin, localize a toxin payload, or otherwise provide means to locally ablate cells.

In another preferred embodiment, the antibody is conjugated to an effector moiety. The effector moiety can be various molecules, including labeling moieties such as radioactive labels or fluorescent labels, or can be a therapeutic moiety. In one aspect the therapeutic moiety is a small molecule that modulates the activity of a cancer protein. In another aspect the therapeutic moiety may modulate the activity of molecules associated with or in close proximity to a cancer protein. The therapeutic moiety may inhibit enzymatic or signaling activity such as protease or collagenase or protein kinase activity associated with cancer, or be an attractant of other cells, such as NK cells.

In a preferred embodiment, the therapeutic moiety can also be a cytotoxic agent. In this method, targeting the cytotoxic agent to cancer tissue or cells results in a reduction in the number of afflicted cells, thereby reducing symptoms associated with cancer. Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their corresponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, phenomycin, enomycin, saporin, auristatin, and the like. Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against cancer proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody. Targeting the therapeutic moiety to transmembrane cancer proteins not only serves to increase the local

concentration of therapeutic moiety in the cancer afflicted area, but also serves to reduce deleterious side effects that may be associated with the untargeted therapeutic moiety.

In another preferred embodiment, the cancer protein against which the antibodies are raised is an intracellular protein. In this case, the antibody may be conjugated to a protein which facilitates entry into the cell. In one case, the antibody enters the cell by endocytosis. In another embodiment, a nucleic acid encoding the antibody is administered to the individual or cell. Moreover, wherein the cancer protein can be targeted within a cell, e. g. , the nucleus, an<BR> antibody thereto may contain a signal for that target localization, e. g. , a nuclear localization signal.

The cancer antibodies of the invention specifically bind to cancer proteins. By "specifically bind"herein is meant that the antibodies bind to the protein with a Kd of at least about 0.1 mM, more usually at least about 1, uM, preferably at least about 0. 1 AM or better, and most preferably, 0.01 AM or better. Selectivity of binding to the specific target and not to related sequences is often also important.

Detection of cancer sequence for diagnostic and therapeutic applications In one aspect, the RNA expression levels of genes are determined for different cellular states in the cancer phenotype. Expression levels of genes in normal tissue (e. g. , not undergoing cancer) and in cancer tissue (and in some cases, for varying severities of cancer that relate to prognosis, as outlined below), or in non-malignant disease are evaluated to provide expression profiles. A gene expression profile of a particular cell state or point of development is essentially a"fingerprint"of the state of the cell. While two states may have a particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is reflective of the state of the cell. By comparing expression profiles of cells in different states, information regarding which genes are important (including both up-and down-regulation of genes) in each of these states is obtained. Then, diagnosis may be performed or confirmed to determine whether a tissue sample has the gene expression profile of normal or cancerous tissue. This will provide for molecular diagnosis of related conditions.

"Differential expression, "or grammatical equivalents as used herein, refers to qualitative or quantitative differences in the temporal and/or cellular gene expression patterns within and among cells and tissue. Thus, a differentially expressed gene can qualitatively have its <BR> <BR> expression altered, including an activation or inactivation, in, e. g. , normal versus cancer tissue.

Genes may be turned on or turned off in a particular state, relative to another state thus

permitting comparison of two or more states. A qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques. Some genes will be expressed in one state or cell type, but not in both. Alternatively, the difference in expression may be quantitative, e. g. , in that expression is increased or decreased; e. g. , gene expression is either upregulated, resulting in an increased amount of transcript, or downregulated, resulting in a decreased amount of transcript. The degree to which expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChipTM expression arrays. See, Lockhart (1996) Nature Biotechnology 14: 1675-1680. Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, northern analysis, and RNase protection. As outlined above, preferably the change in expression (e. g. , upregulation or downregulation) is at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably at least about 200%, with from 300 to at least 1000% being especially preferred.

Evaluation may be at the gene transcript or the protein level. The amount of gene expression may be monitored using nucleic acid probes to the RNA or DNA equivalent of the gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene <BR> <BR> product itself (protein) can be monitored, e. g. , with antibodies to the cancer protein and standard<BR> immunoassays (ELISAs, etc. ) or other techniques, including mass spectroscopy assays, 2D gel<BR> electrophoresis assays, etc. Proteins corresponding to cancer genes, e. g. , those identified as being important in a cancer or disease phenotype, can be evaluated in a cancer diagnostic test.

In a preferred embodiment, gene expression monitoring is performed simultaneously on a number of genes. Multiple protein expression monitoring can be performed as well.

In this embodiment, the cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of cancer sequences in a particular cell. The assays are further described below in the example. PCR techniques can be used to provide greater sensitivity.

In a preferred embodiment nucleic acids encoding the cancer protein are detected.

Although DNA or RNA encoding the cancer protein may be detected, of particular interest are methods wherein an mRNA encoding a cancer protein is detected. Probes to detect mRNA can be a nucleotide/deoxynucleotide probe that is complementary to and hybridizes with the mRNA and includes, but is not limited to, oligonucleotides, cDNA, or RNA. Probes also should contain a detectable label, as defined herein. In one method the mRNA is detected after

immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample. Following washing to remove the non-specifically bound probe, the label is detected. In another method, detection of the mRNA is performed in situ. In this method permeabilized cells or tissue samples are contacted with a detectably labeled nucleic acid probe for sufficient time to allow the probe to hybridize with the target mRNA. Following washing to remove the non-specifically bound probe, the label is detected.

For example a digoxygenin labeled riboprobe (RNA probe) that is complementary to the mRNA encoding a cancer protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.

In a preferred embodiment, various proteins from the three classes of proteins as described herein (secreted, transmembrane, or intracellular proteins) are used in diagnostic assays. The cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in diagnostic assays. This can be performed on an individual gene or corresponding polypeptide level. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes and/or corresponding polypeptides.

As described and defined herein, cancer proteins, including intracellular, transmembrane, or secreted proteins, find use as markers of cancer, e. g. , for prognostic or diagnostic purposes. Detection of these proteins in putative cancer tissue allows for detection, prognosis, or diagnosis of cancer or similar disease, and for selection of therapeutic strategy. In one embodiment, antibodies are used to detect cancer proteins. A preferred method separates proteins from a sample by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be another type of gel, including isoelectric focusing gels and the like). Following <BR> <BR> separation of proteins, the cancer protein is detected, e. g. , by immunoblotting with antibodies raised against the cancer protein.

In another preferred method, antibodies to the cancer protein find use in in situ imaging techniques, e. g. , in histology. See, e. g. , Asai, et al. (eds. 1993) Methods in Cell Biology : Antibodies in Cell Biology (vol. 37) Academic Press. In this method, cells are contacted with from one to many antibodies to the cancer protein (s). Following washing to remove non- specific antibody binding, the presence of the antibody or antibodies is detected. In one embodiment the antibody is detected by incubating with a secondary antibody that contains a

detectable label. In another method the primary antibody to the cancer protein (s) contains a detectable label, e. g. , an enzyme marker that can act on a substrate. In another preferred embodiment each one of multiple primary antibodies contains a distinct and detectable label.

This method finds particular use in simultaneous screening for a plurality of cancer proteins.

Many other histological imaging techniques are also provided by the invention.

In a preferred embodiment the label is detected in a fluorometer which has the ability to detect and distinguish emissions of different wavelengths. In addition, a fluorescence activated cell sorter (FACS) can be used in the method.

In another preferred embodiment, antibodies find use in diagnosing cancer from blood, serum, plasma, stool, and other samples. Such samples, therefore, are useful as samples to be probed or tested for the presence of cancer proteins. Antibodies can be used to detect a cancer protein by previously described immunoassay techniques including ELISA, immunoblotting (western blotting), immunoprecipitation, BIACORE technology and the like. Conversely, the presence of antibodies may indicate an immune response against an endogenous cancer protein.

In a preferred embodiment, in situ hybridization of labeled cancer nucleic acid probes to tissue arrays is done. For example, arrays of tissue samples, including cancer tissue and/or normal tissue, are made. In situ hybridization (see, e. g. , Ausubel, supra) is then performed.

When comparing the fingerprints between an individual and a standard, a diagnosis, a prognosis, or a prediction may be based on the findings. It is further understood that the genes which indicate the diagnosis may differ from those which indicate the prognosis and molecular profiling of the condition of the cells may lead to distinctions between responsive or refractory conditions or may be predictive of outcomes.

In a preferred embodiment, the cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in prognosis assays. As above, gene expression profiles can be generated that correlate to cancer, clinical, pathological, or other information, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of genes being preferred. Single or multiple genes may be useful in various combinations. As above, cancer probes may be attached to biochips for the detection and quantification of cancer sequences in a tissue or patient. The assays proceed as outlined above for diagnosis. PCR method may provide more sensitive and accurate quantification.

Assays for therapeutic compounds In a preferred embodiment, the proteins, nucleic acids, and antibodies as described herein are used in drug screening assays. The cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in drug screening assays or by evaluating the effect of drug candidates on a"gene expression profile"or expression profile of polypeptides. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques, to allow monitoring for expression profile genes after treatment with a candidate agent (e. g., Zlokarnik, et al. (1998) Science 279: 84-88; Heid (1996) Genome Res. 6: 986-994.

In a preferred embodiment, the cancer proteins, antibodies, nucleic acids, modified proteins and cells containing the native or modified cancer proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions which modulate the cancer phenotype or an identified physiological function of a cancer protein. As above, this can be done on an individual gene level or by evaluating the effect of drug candidates on a"gene expression profile". In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques, to allow monitoring for expression profile genes after treatment with a candidate agent, see Zlokarnik, supra.

Having identified the differentially expressed genes herein, a variety of assays may be performed. In a preferred embodiment, assays may be run on an individual gene or protein level. That is, having identified a particular gene as up regulated in cancer, test compounds can be screened for the ability to modulate gene expression or for binding to the cancer protein.

"Modulation"thus includes both an increase and a decrease in gene expression. The preferred amount of modulation will depend on the original change of the gene expression in normal versus tissue undergoing cancer, with changes of at least 10%, preferably 50%, more preferably 100-300%, and in some embodiments 300-1000% or greater. Thus, if a gene exhibits a 4-fold increase in cancer tissue compared to normal tissue, a decrease of about four-fold is often desired; similarly, a 10-fold decrease in cancer tissue compared to normal tissue often provides a target value of a 10-fold increase in expression to be induced by the test compound.

The amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the gene product itself can be

monitored, e. g. , through the use of antibodies to the cancer protein and standard immunoassays.

Proteomics and separation techniques may also allow quantification of expression.

In a preferred embodiment, gene expression or protein monitoring of a number of entities, e. g. , an expression profile, is monitored simultaneously. Such profiles will typically involve a plurality of those entities described herein.

In this embodiment, the cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of cancer sequences in a particular cell.

Alternatively, PCR may be used. Thus, a series, e. g., of microtiter plate, may be used with dispensed primers in desired wells. A PCR reaction can then be performed and analyzed for each well.

Modulators of cancer Expression monitoring can be performed to identify compounds that modify the expression of one or more cancer-associated sequences, e. g., a polynucleotide sequence set out in the tables. Generally, in a preferred embodiment, a test modulator is added to the cells prior to analysis. Moreover, screens are also provided to identify agents that modulate cancer, modulate cancer proteins, bind to a cancer protein, or interfere with the binding of a cancer protein and an antibody or other binding partner.

The term"test compound"or"drug candidate"or"modulator"or grammatical <BR> <BR> equivalents as used herein describes a molecule, e. g. , protein, oligopeptide, small organic<BR> molecule, polysaccharide, polynucleotide, etc. , to be tested for the capacity to directly or<BR> indirectly alter the cancer phenotype or the expression of a cancer sequence, e. g. , a nucleic acid or protein sequence. In preferred embodiments, modulators alter expression profiles, or expression profile nucleic acids or proteins provided herein. In one embodiment, the modulator <BR> <BR> suppresses a cancer phenotype, e. g. , to a normal or non-malignant tissue fingerprint. In another embodiment, a modulator induced a cancer phenotype. Generally, a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations. Typically, one of these concentrations serves as a negative control, e. g., at zero concentration or below the level of detection.

Drug candidates encompass numerous chemical classes, though typically they are organic molecules, preferably small organic compounds having a molecular weight of more than 100 and less than about 2,500 daltons. Preferred small molecules are less than 2000, or

less than 1500, or less than 1000, or less than 500 D. Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl or carboxyl group, preferably at least two of the functional chemical groups. The candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups. Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs, or combinations thereof. Particularly preferred are peptides.

In one aspect, a modulator will neutralize the effect of a cancer protein. By"neutralize" is meant that activity of a protein is inhibited or blocked and the consequent effect on the cell.

In certain embodiments, combinatorial libraries of potential modulators will be screened for an ability to bind to a cancer polypeptide or to modulate activity. Conventionally, new chemical entities with useful properties are generated by identifying a chemical compound (called a"lead compound") with some desirable property or activity, e. g. , inhibiting activity, creating variants of the lead compound, and evaluating the property and activity of those variant compounds. Often, high throughput screening (HTS) methods are employed for such an analysis. See, e. g. , Janzen (2002) High Throughput Screening : Methods and Protocols Humana; Devlin (ed. 1997) High Throughput Screening : The Discovery of Bioactive Substances Dekker; and Mei and Czarnik (eds. 2002) Integrated Drug Discovery Techniques Dekker.

In one preferred embodiment, high throughput screening methods involve providing a library containing a large number of potential therapeutic compounds (candidate compounds).

Such"combinatorial chemical libraries"are then screened in one or more assays to identify those library members (particular chemical species or subclasses) that display a desired characteristic activity. The compounds thus identified can serve as conventional"lead compounds"or can themselves be used as potential or actual therapeutics.

A combinatorial chemical library is a collection of diverse chemical compounds generated by either chemical synthesis or biological synthesis by combining a number of chemical"building blocks"such as reagents. For example, a linear combinatorial chemical library, such as a polypeptide (e. g. , mutein) library, is formed by combining a set of chemical<BR> building blocks called amino acids in every possible way for a given compound length (e. g. , the number of amino acids in a polypeptide compound). Millions of chemical compounds can be

synthesized through such combinatorial mixing of chemical building blocks (Gallop, et al.

(1994) J. Med. Chem. 37: 1233-1251).

Preparation and screening of combinatorial chemical libraries is well known. Such <BR> <BR> combinatorial chemical libraries include, but are not limited to, peptide libraries (see, e. g. , U. S.

Patent No. 5,010, 175, Furka (1991) Pept. Prot. Res. 37: 487-493, Houghton, et al. (1991) Nature 354: 84-88), peptoids (PCT Publication No WO 91/19735), encoded peptides (PCT Publication WO 93/20242), random bio-oligomers (PCT Publication WO 92/00091), benzodiazepines (U. S.

Pat. No. 5, 288, 514), diversomers such as hydantoins, benzodiazepines and dipeptides (Hobbs, et al. (1993) Proc. Nat. Acad. Sci. USA 90: 6909-6913, vinylogous polypeptides (Hagihara, et al.

(1992) J. Amer. Chem. Soc. 114: 6568-570), nonpeptidal peptidomimetics with a Beta-D- Glucose scaffolding (Hirschmann, et al. (1992) J. Amer. Chem. Soc. 114: 9217-9218), analogous organic syntheses of small compound libraries (Chen, et al. (1994) J. Amer. Chem.

Soc. 116: 2661-662), oligocarbamates (Cho, et al. (1993) Science 261: 1303-1305), and/or peptidyl phosphonates (Campbell, et al. (1994) J. Org. Chem. 59: 658-xxx). See, generally, <BR> <BR> Gordon, et al. (1994) J. Med. Chem. 37: 1385-1401, nucleic acid libraries (see, e. g. , Stratagene,<BR> Corp. ), peptide nucleic acid libraries (see, e. g. , U. S. Patent 5,539, 083), antibody libraries (see,<BR> e. g. , Vaughn, et al. (1996) Nature Biotechnology 14 (3): 309-314, and PCT/US96/10287),<BR> carbohydrate libraries (see, e. g. , Liang, et al. (1996) Science 274: 1520-1522, and U. S. Patent<BR> No. 5,593, 853), and small organic molecule libraries (see, e. g. , benzodiazepines, page 33 Baum (Jan 18,1993) C&EN ; isoprenoids, U. S. Patent No. 5,569, 588 ; thiazolidinones and metathiazanones, U. S. Patent No. 5,549, 974; pyrrolidines, U. S. Patent Nos. 5,525, 735 and 5,519, 134; morpholino compounds, U. S. Patent No. 5,506, 337; benzodiazepines, U. S. Patent No. 5, 288, 514; and the like).

Devices for the preparation of combinatorial libraries are commercially available (see, <BR> <BR> e. g. , 357 MPS, 390 MPS, Advanced Chem Tech, Louisville KY, Symphony, Rainin, Woburn, MA, 433A Applied Biosystems, Foster City, CA, 9050 Plus, Millipore, Bedford, MA).

A number of well known robotic systems have also been developed for solution phase chemistries. These systems include automated workstations like the automated synthesis apparatus developed by Takeda Chemical Industries, LTD. (Osaka, Japan) and many robotic systems utilizing robotic arms (Zymate II, Zymark Corporation, Hopkinton, Mass.; Orca, Hewlett-Packard, Palo Alto, Calif.), which mimic the manual synthetic operations performed by a chemist. The above devices are suitable for use with the present invention. The nature and

implementation of modifications to these devices (if any) so that they can operate as discussed herein will be apparent. In addition, numerous combinatorial libraries are themselves <BR> <BR> commercially available (see, e. g. , ComGenex, Princeton, N. J. , Asinex, Moscow, Ru, Tripos,<BR> Inc. , St. Louis, MO, ChemStar, Ltd, Moscow, RU, 3D Pharmaceuticals, Exton, PA, Martek Biosciences, Columbia, MD, etc.).

The assays to identify modulators are amenable to high throughput screening. Preferred assays thus detect enhancement or inhibition of cancer gene transcription, inhibition, or enhancement of polypeptide expression, and inhibition or enhancement of polypeptide activity.

High throughput assays for the presence, absence, quantification, or other properties of particular nucleic acids or protein products are well known. Similarly, binding assays and <BR> <BR> reporter gene assays are similarly well known. Thus, e. g. , U. S. Patent No. 5,559, 410 discloses high throughput screening methods for proteins, U. S. Patent No. 5, 585, 639 discloses high <BR> <BR> throughput screening methods for nucleic acid binding (e. g. , in arrays), while U. S. Patent Nos.

5,576, 220 and 5,541, 061 disclose high throughput methods of screening for ligand/antibody binding.

In addition, high throughput screening systems are commercially available (see, e. g., <BR> <BR> Zymark Corp. , Hopkinton, MA; Air Technical Industries, Mentor, OH; Beckman Instruments,<BR> Inc. Fullerton, CA; Precision Systems, Inc. , Natick, MA, etc. ). These systems typically automate entire procedures, including sample and reagent pipetting, liquid dispensing, timed incubations, and final readings of the microplate in detector (s) appropriate for the assay. These configurable systems provide high throughput and rapid start up as well as a high degree'of flexibility and customization. The manufacturers of such systems provide detailed protocols for various high throughput systems. Thus, e. g. , Zymark Corp. provides technical bulletins describing screening systems for detecting the modulation of gene transcription, ligand binding, and the like.

In one embodiment, modulators are proteins, often naturally occurring proteins or fragments of naturally occurring proteins. Thus, e. g. , cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, may be used. In this way libraries of proteins may be made for screening in the methods of the invention. Particularly preferred in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being preferred, and human proteins being especially preferred. Particularly useful test

compound will be directed to the class of proteins to which the target belongs, e. g. , substrates for enzymes or ligands and receptors.

In a preferred embodiment, modulators are peptides of from about 5-30 amino acids, with from about 5-20 amino acids being preferred, and from about 7-15 being particularly preferred. The peptides may be digests of naturally occurring proteins, random peptides, or "biased"random peptides. By"randomized"or grammatical equivalents herein is meant that each nucleic acid and peptide consists of essentially random nucleotides and amino acids, respectively. Since generally these random peptides (or nucleic acids, discussed below) are chemically synthesized, they may incorporate a nucleotide or amino acid at any position. The synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of all or most of the possible combinations over the length of the sequence, thus forming a library of randomized candidate bioactive proteinaceous agents.

In one embodiment, the library is fully randomized, with no sequence preferences or constants at any position. In a preferred embodiment, the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities. For example, in a preferred embodiment, the nucleotides or amino acid residues are randomized within a defined class, e. g., of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines, or histidines for phosphorylation sites, etc. , or to purines, etc.

Modulators of cancer can also be nucleic acids, as defined above.

As described above generally for proteins, nucleic acid modulating agents may be naturally occurring nucleic acids, random nucleic acids, or"biased"random nucleic acids. For example, digests of prokaryotic or eukaryotic genomes may be used as is outlined above for proteins.

In a preferred embodiment, the candidate compounds are organic chemical moieties, a wide variety of which are available in the literature.

After the candidate agent has been added and the cells allowed to incubate for some period of time, the sample containing a target sequence to be analyzed is added to the biochip.

If required, the target sequence is prepared using known techniques. For example, the sample may be treated to lyse the cells, using known lysis buffers, electroporation, etc. , with purification and/or amplification such as PCR performed as appropriate. For example, an in

vitro transcription with labels covalently attached to the nucleotides is performed. Generally, the nucleic acids are labeled with biotin-FITC or PE, or with cy3 or cy5.

In a preferred embodiment, the target sequence is labeled with, e. g. , a fluorescent, a chemiluminescent, a chemical, or a radioactive signal, to provide a means of detecting the target sequence's specific binding to a probe. The label also can be an enzyme, such as, alkaline phosphatase or horseradish peroxidase, which when provided with an appropriate substrate produces a product that can be detected. Alternatively, the label can be a labeled compound or small molecule, such as an enzyme inhibitor, that binds but is not catalyzed or altered by the enzyme. The label also can be a moiety or compound, such as, an epitope tag or biotin which specifically binds to streptavidin. For the example of biotin, the streptavidin is labeled as described above, thereby, providing a detectable signal for the bound target sequence. Unbound labeled streptavidin is typically removed prior to analysis.

These assays can be direct hybridization assays or can comprise"sandwich assays", which include the use of multiple probes, as is generally outlined in U. S. Patent Nos. 5,681, 702, 5,597, 909,5, 545,730, 5,594, 117,5, 591,584, 5,571, 670,5, 580, 731,5, 571,670, 5,591, 584, 5,624, 802,5, 635,352, 5, 594,118, 5,359, 100, 5,124, 246, and 5,681, 697, all of which are hereby incorporated by reference. In this embodiment, in general, the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex.

A variety of hybridization conditions may be used in the present invention, including high, moderate, and low stringency conditions as outlined above. The assays are generally run under stringency conditions which allows formation of the label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaotropic salt concentration, pH, organic solvent concentration, etc.

These parameters may also be used to control non-specific binding, as is generally outlined in U. S. Patent No. 5,681, 697. Thus it may be desirable to perform certain steps at higher stringency conditions to reduce non-specific binding.

The reactions outlined herein may be accomplished in a variety of ways. Components of the reaction may be added simultaneously, or sequentially, in different orders, with preferred embodiments outlined below. In addition, the reaction may include a variety of other reagents. <BR> <BR> <P>These include salts, buffers, neutral proteins, e. g. , albumin, detergents, etc. which may be used

to facilitate optimal hybridization and detection, and/or reduce non-specific or background interactions. Reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc. , may also be used as appropriate, depending on the sample preparation methods and purity of the target.

The assay data are analyzed to determine the expression levels, and changes in expression levels as between states of individual genes, forming a gene expression profile.

Screens are performed to identify modulators of the cancer phenotype. In one embodiment, screening is performed to identify modulators that can induce or suppress a particular expression profile, thus preferably generating the associated phenotype. In another embodiment, e. g. , for diagnostic applications, having identified differentially expressed genes important in a particular state, screens can be performed to identify modulators that alter expression of individual genes. In an another embodiment, screening is performed to identify modulators that alter a biological function of the expression product of a differentially expressed gene. Again, having identified the importance of a gene in a particular state, screens are performed to identify agents that bind and/or modulate the biological activity of the gene product.

In addition, screens can be done for genes that are induced in response to a candidate agent or treatment process. After identifying a modulator based upon its ability to suppress a cancer expression pattern leading to a normal expression pattern (or its converse), or to modulate a single cancer gene expression profile so as to mimic the expression of the gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated cancer tissue reveals genes that are not expressed in normal tissue or cancer tissue, but are expressed in agent treated tissue. These agent-specific sequences can be identified and used by methods described herein for cancer genes or proteins. In particular, these sequences and the proteins they encode find use in marking or identifying agent treated cells. In addition, antibodies can be raised against the agent induced proteins and used to target novel therapeutics to the treated cancer tissue sample.

Thus, in one embodiment, a test compound is administered to a population of cancer cells that have an associated cancer expression profile. By"administration"or"contacting" herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell

surface. In some embodiments, nucleic acid encoding a proteinaceous candidate agent (e. g. , a peptide) may be put into a viral construct such as an adenoviral or retroviral construct, and added to the cell, such that expression of the peptide agent is accomplished, e. g. , PCT US97/01019. Regulatable gene therapy systems can also be used.

Once a test compound has been administered to the cells, the cells can be washed if desired and are allowed to incubate under preferably physiological conditions for some period of time. The cells are then harvested and a new gene expression profile is generated, as outlined herein.

Thus, e. g. , cancer or non-malignant tissue may be screened for agents that modulate,<BR> e. g. , induce or suppress a cancer phenotype. A change in at least one gene, preferably many, of the expression profile indicates that the agent has an effect on cancer activity. By defining such a signature for the cancer phenotype, screens for new drugs that alter the phenotype can be devised. With this approach, the drug target need not be known and need not be represented in the original expression screening platform, nor does the level of transcript for the target protein need to change.

In a preferred embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of either the expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes referred to herein as"cancer proteins"or a"cancer modulatory protein". The cancer modulatory protein may be a fragment, or alternatively, be the full length protein to the fragment encoded by the nucleic acids of the Tables. Preferably, the cancer modulatory protein is a fragment. In a preferred embodiment, the cancer amino acid sequence which is used to determine sequence identity or similarity is encoded by a nucleic acid of the Tables. In another embodiment, the sequences are naturally occurring allelic variants of a protein encoded by a nucleic acid of the Tables. In another embodiment, the sequences are sequence variants as further described herein.

Preferably, the cancer modulatory protein is a fragment of about 14-24 amino acids long. More preferably the fragment is a soluble fragment. Preferably, the fragment includes a non-transmembrane region. In a preferred embodiment, the fragment has an N-terminal Cys to aid in solubility. In one embodiment, the C-terminus of the fragment is kept as a free acid and the N-terminus is a free amine to aid in coupling, e. g. , to cysteine.

In one embodiment the cancer proteins are conjugated to an immunogenic agent as discussed herein. In one embodiment the cancer protein is conjugated to BSA.

Measurements of cancer polypeptide activity, or of cancer or the cancer phenotype can be performed using a variety of assays. For example, the effects of the test compounds upon the function of the cancer polypeptides can be measured by examining parameters described above.

A suitable physiological change that affects activity can be used to assess the influence of a test compound on the polypeptides of this invention. When the functional consequences are determined using intact cells or animals, one can also measure a variety of effects such as, in the case of cancer associated with tumors, tumor growth, tumor metastasis, neovascularization, hormone release, transcriptional changes to both known and uncharacterized genetic markers (e. g. , northern blots), changes in cell metabolism such as cell growth or pH changes, and changes in intracellular second messengers such as cGMP. In the assays of the invention, mammalian cancer polypeptide is typically used, e. g. , mouse, preferably human.

Assays to identify compounds with modulating activity can be performed in vitro. For example, a cancer polypeptide is first contacted with a potential modulator and incubated for a <BR> <BR> suitable amount of time, e. g. , from 0.5-48 hours. In one embodiment, the cancer polypeptide levels are determined in vitro by measuring the level of protein or mRNA. The level of protein is typically measured using immunoassays such as western blotting, ELISA, and the like with an antibody that selectively binds to the cancer polypeptide or a fragment thereof. For measurement of mRNA, amplification, e. g. , using PCR, LCR, or hybridization assays, e. g., northern hybridization, RNAse protection, dot blotting, are preferred. The level of protein or mRNA is typically detected using directly or indirectly labeled detection agents, e. g., fluorescently or radioactively labeled nucleic acids, radioactively or enzymatically labeled antibodies, and the like, as described herein.

Alternatively, a reporter gene system can be devised using a cancer protein promoter operably linked to a reporter gene such as luciferase, green fluorescent protein, CAT, or 0-gal.

The reporter construct is typically transfected into a cell. After treatment with a potential modulator, the amount of reporter gene transcription, translation, or activity is measured according to standard techniques.

In a preferred embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of the expression of the gene or

the gene product itself can be done. The gene products of differentially expressed genes are sometimes referred to herein as"cancer proteins. "The cancer protein may be a fragment, or alternatively, the full length protein to a fragment shown herein.

In one embodiment, screening for modulators of expression of specific genes is performed. Typically, the expression of only one or a few genes are evaluated. In another embodiment, screens are designed to first find compounds that bind to differentially expressed proteins. These compounds are then evaluated for the ability to modulate differentially expressed activity. Moreover, once initial candidate compounds are identified, variants can be further screened to better evaluate structure activity relationships.

In a preferred embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more differentially expressed nucleic acids are made. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the cancer proteins can be used in the assays.

Thus, in a preferred embodiment, the methods comprise combining a cancer protein and a candidate compound, and determining the binding of the compound to the cancer protein.

Preferred embodiments utilize the human cancer protein, although other mammalian proteins may also be used, e. g. , for the development of animal models of human disease. In some embodiments, as outlined herein, variant or derivative cancer proteins may be used.

Generally, in a preferred embodiment of the methods herein, the cancer protein or the candidate agent is non-diffusably bound to an insoluble support, preferably having isolated <BR> <BR> sample receiving areas (e. g. , a microtiter plate, an array, etc. ). The insoluble supports may be made of a composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening. The surface of such supports may be solid or porous and of a convenient shape. Examples of suitable insoluble supports include microtiter plates, arrays, membranes, and beads. These are typically <BR> <BR> made of glass, plastic (e. g. , polystyrene), polysaccharides, nylon or nitrocellulose, teflonTM, etc.

Microtiter plates and arrays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples. The particular manner of binding of the composition is typically not crucial so long as it is compatible with the reagents and overall methods of the invention, maintains the activity of the composition, and is nondiffusable. Preferred methods of binding include the use of antibodies (which do not

sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to"sticky"or ionic supports, chemical crosslinking, the synthesis of the protein or agent on the surface, etc. Following binding of the protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein, or other innocuous protein or other moiety.

In a preferred embodiment, the cancer protein is bound to the support, and a test compound is added to the assay. Alternatively, the candidate agent is bound to the support and the cancer protein is added. Novel binding agents include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this purpose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc. ), and the like.

The determination of the binding of the test modulating compound to the cancer protein may be done in a number of ways. In a preferred embodiment, the compound is labeled, and <BR> <BR> binding determined directly, e. g. , by attaching all or a portion of the cancer protein to a solid<BR> support, adding a labeled candidate agent (e. g. , a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support. Various blocking and washing steps may be utilized as appropriate.

In some embodiments, only one of the components is labeled, e. g. , the proteins (or proteinaceous candidate compounds) can be labeled. Alternatively, more than one component can be labeled with different labels, e. g., 1251 for the proteins and a fluorophor for the compound. Proximity reagents, e. g. , quenching or energy transfer reagents are also useful.

In one embodiment, the binding of the test compound is determined by competitive binding assay. The competitor may be a binding moiety known to bind to the target molecule <BR> <BR> (e. g. , a cancer protein), such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding between the compound and the binding moiety, with the binding moiety displacing the compound. In one embodiment, the test compound is labeled. Either the compound, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at a temperature which facilitates optimal activity, typically between about 4-40° C. Incubation

periods are typically optimized, e. g. , to facilitate rapid high throughput screening. Typically between 0.1-1 hour will be sufficient. Excess reagent is generally removed or washed away.

The second component is then added, and the presence or absence of the labeled component is followed, to indicate binding.

In a preferred embodiment, the competitor is added first, followed by a test compound.

Displacement of the competitor is an indication that the test compound is binding to the cancer protein and thus is capable of binding to, and potentially modulating, the activity of the cancer <BR> <BR> protein. In this embodiment, either component can be labeled. Thus, e. g. , if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent.

Alternatively, if the test compound is labeled, the presence of the label on the support indicates displacement.

In an alternative embodiment, the test compound is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate that the test compound is bound to the cancer protein with a higher affinity. Thus, if the test compound is labeled, the presence of the label on the support, coupled with a lack of competitor binding, may indicate that the test compound is capable of binding to the cancer protein.

In a preferred embodiment, the methods comprise differential screening to identity agents that are capable of modulating the activity of the cancer proteins. In one embodiment, the methods comprise combining a cancer protein and a competitor in a first sample. A second sample comprises a test compound, a cancer protein, and a competitor. The binding of the competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the cancer protein and potentially modulating its activity. That is, if the binding of the competitor is different in the second sample relative to the first sample, the agent is capable of binding to the cancer protein.

Alternatively, differential screening is used to identify drug candidates that bind to the native cancer protein, but cannot bind to modified cancer proteins. The structure of the cancer protein may be modeled, and used in rational drug design to synthesize agents that interact with that site. Drug candidates that affect the activity of a cancer protein are also identified by screening drugs for the ability to either enhance or reduce the activity of the protein.

Positive controls and negative controls may be used in the assays. Preferably control and test samples are performed in at least triplicate to obtain statistically significant results.

Incubation of all samples is for a time sufficient for the binding of the agent to the protein.

Following incubation, samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound.

A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e. g. , albumin, detergents, etc. , which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions.

Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used. The mixture of components may be added in an order that provides for the requisite binding.

In a preferred embodiment, the invention provides methods for screening for a compound capable of modulating the activity of a cancer protein. The methods comprise adding a test compound, as defined above, to a cell comprising cancer proteins. Preferred cell types include almost any cell. The cells contain a recombinant nucleic acid that encodes a cancer protein. In a preferred embodiment, a library of candidate agents are tested on a plurality of cells.

In one aspect, the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, e. g., hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including <BR> <BR> chemotherapeutics, radiation, carcinogenics, or other cells (e. g. , cell-cell contacts). In another example, the determinations are determined at different stages of the cell cycle process.

In this way, compounds that modulate cancer agents are identified. Compounds with pharmacological activity are able to enhance or interfere with the activity of the cancer protein.

Once identified, similar structures are evaluated to identify critical structural feature of the compound.

In one embodiment, a method of inhibiting cancer cell division is provided. The method comprises administration of a cancer inhibitor. In another embodiment, a method of inhibiting cancer is provided. The method may comprise administration of a cancer inhibitor. In a further <BR> <BR> embodiment, methods of treating cells or individuals with cancer are provided, e. g. , comprising administration of a cancer inhibitor.

In one embodiment, a cancer inhibitor is an antibody as discussed above. In another embodiment, the cancer inhibitor is an antisense molecule.

A variety of cell growth, proliferation, viability, and metastasis assays are available, as described below.

Soft agar growth or colony formation in suspension Normal cells require a solid substrate to attach and grow. When the cells are transformed, they lose this phenotype and grow detached from the substrate. For example, transformed cells can grow in stirred suspension culture or suspended in semi-solid media, such as semi-solid or soft agar. The transformed cells, when transfected with tumor suppressor genes, regenerate normal phenotype and require a solid substrate to attach and grow. Soft agar growth or colony formation in suspension assays can be used to identify modulators of cancer sequences, which when expressed in host cells, inhibit abnormal cellular proliferation and transformation. A therapeutic compound would reduce or eliminate the host cells'ability to grow in stirred suspension culture or suspended in semi-solid media, such as semi-solid or soft.

Techniques for soft agar growth or colony formation in suspension assays are described, <BR> <BR> e. g. , in Freshney (1998) Culture of Animal Cells: A Manual of Basic Technique (3d ed. ) Wiley-<BR> Liss; Freshney (2000) Culture of Animal Cells: A Manual of Basic Technique (4th ed. ) Wiley- Liss; and Garkavtsev, et al. (1996) Nature Genet. 14: 415-20.

Contact inhibition and density limitation of growth Normal cells typically grow in a flat and organized pattern in a petri dish until they touch other cells. When the cells touch one another, they are contact inhibited and stop growing. When cells are transformed, however, the cells are not contact inhibited and continue to grow to high densities in disorganized foci. Thus, the transformed cells grow to a higher saturation density than normal cells. This can be detected morphologically by the formation of a disoriented monolayer of cells or rounded cells in foci within the regular pattern of normal <BR> <BR> surrounding cells. Alternatively, labeling index with (3H) -thymidine at saturation density can be used to measure density limitation of growth. See Freshney (2000), supra. The transformed cells, when transfected with tumor suppressor genes, regenerate a normal phenotype and become contact inhibited and would grow to a lower density.

In this assay, labeling index with (3H)-thymidine at saturation density is a preferred method of measuring density limitation of growth. Transformed host cells are transfected with a cancer-associated sequence and are grown for 24 hours at saturation density in non-limiting medium conditions. The percentage of cells labeling with (3H)-thymidine is determined autoradiographically. See, Freshney (1998), supra.

Growth factor or serum dependence Transformed cells typically have a lower serum dependence than their normal counterparts (see, e. g. , Temin (1966) J. Natl. Cancer Insti. 37: 167-175; Eagle, et al. (1970) J.

Exp. Med. 131: 836-879) ; Freshney, supra. This is in part due to release of various growth factors by the transformed cells. Growth factor or serum dependence of transformed host cells can be compared with that of control.

Tumor specific markers levels Tumor cells release an increased amount of certain factors (hereinafter"tumor specific markers") than their normal counterparts. For example, plasminogen activator (PA) is released from human glioma at a higher level than from normal brain cells (see, e. g. , Gullino "Angiogenesis, tumor vascularization, and potential interference with tumor growth"pp. 178- 184 in Mihich (ed. 1985) Biological Responses in Cancer Plenum. Similarly, tumor angiogenesis factor (TAF) is released at a higher level in tumor cells than their normal counterparts. See, e. g. , Folkman (1992) Sem. Cancer Biol. 3: 89-96.

Various techniques which measure the release of these factors are described in Freshney (1998), supra. Also, see, Unkeless, et al. (1974) J. Biol. Chem. 249: 4295-4305; Strickland and Beers (1976) J. Biol. Chem. 251: 5694-5702 ; Whur, et al. (1980) Br. J. Cancer 42 : 305-312 ; Gullino"Angiogenesis, tumor vascularization, and potential interference with tumor growth" pp. 178-184 in Mihich (ed. 1985) Biological Responses in Cancer Plenum; Freshney (1985) Anticancer Res. 5: 111-130.

Invasiveness into Matrigel The degree of invasiveness into Matrigel or some other extracellular matrix constituent can be used as an assay to identify compounds that modulate cancer-associated sequences.

Tumor cells exhibit a good correlation between malignancy and invasiveness of cells into Matrigel or some other extracellular matrix constituent. In this assay, tumorigenic cells are typically used as host cells. Expression of a tumor suppressor gene in these host cells would decrease invasiveness of the host cells.

Techniques described in Freshney (1994), supra, can be used. Briefly, the level of invasion of host cells can be measured by using filters coated with Matrigel or some other extracellular matrix constituent. Penetration into the gel, or through to the distal side of the filter, is rated as invasiveness, and rated histologically by number of cells and distance moved,

or by prelabeling the cells with 1251 and counting the radioactivity on the distal side of the filter or bottom of the dish. See, e. g. , Freshney (1984), supra.

Tumor growth in vivo Effects of cancer-associated sequences on cell growth can be tested in transgenic or immune-suppressed mice. Knock-out transgenic mice can be made, in which the cancer gene is disrupted or in which a cancer gene is inserted. Knock-out transgenic mice can be made by insertion of a marker gene or other heterologous gene into the endogenous cancer gene site in the mouse genome via homologous recombination. Such mice can also be made by substituting the endogenous cancer gene with a mutated version of the cancer gene, or by mutating the endogenous cancer gene, e. g. , by exposure to carcinogens.

A DNA construct is introduced into the nuclei of embryonic stem cells. Cells containing the newly engineered genetic lesion are injected into a host mouse embryo, which is re- implanted into a recipient female. Some of these embryos develop into chimeric mice that possess germ cells partially derived from the mutant cell line. Therefore, by breeding the chimeric mice it is possible to obtain a new line of mice containing the introduced genetic lesion (see, e. g. , Capecchi, et al. (1989) Science 244: 1288-1292). Chimeric targeted mice can be derived according to Hogan, et al. (1988) Manipulating the Mouse Embryo : A Laboratory Manual CSH Press; and Robertson (ed. 1987) Teratocarcinomas and Embryonic Stem Cells: A Practical Approach IRL Press, Washington, D. C.

Alternatively, various immune-suppressed or immune-deficient host animals can be used. For example, genetically athymic"nude"mouse (see, e. g. , Giovanella, et al. (1974) J.

Natl. Cancer Inst. 52: 921-930), a SCID mouse, a thymectomized mouse, or an irradiated mouse (see, e. g. , Bradley, et al. (1978) Br. J. Cancer 38: 263-272; Selby, et al. (1980) Br. J. Cancer 41: 52-61) can be used as a host. Transplantable tumor cells (typically about 106 cells) injected into isogenic hosts will produce invasive tumors in a high proportions of cases, while normal cells of similar origin will not. In hosts which developed invasive tumors, cells expressing a cancer-associated sequences are injected subcutaneously. After a suitable length of time, preferably 4-8 weeks, tumor growth is measured (e. g. , by volume or by its two largest dimensions) and compared to the control. Tumors that have statistically significant reduction (using, e. g., Student's T test) are said to have inhibited growth.

Polynucleotide modulators of cancer Antisense and RNAi Polynucleotides In certain embodiments, the activity of a cancer-associated protein is down-regulated, or entirely inhibited, by the use of an inhibitory or antisense polynucleotide, e. g. , a nucleic acid complementary to, and which can preferably hybridize specifically to, a coding mRNA nucleic <BR> <BR> acid sequence, e. g. , a cancer protein mRNA, or a subsequence thereof. Binding of the antisense polynucleotide to the mRNA reduces the translation and/or stability of the mRNA.

In the context of this invention, antisense polynucleotides can comprise naturally- occurring nucleotides, or synthetic species formed from naturally-occurring subunits or their close homologs. Antisense polynucleotides may also have altered sugar moieties or inter-sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species.

Analogs are comprehended by this invention so long as they function effectively to hybridize with the cancer protein mRNA. See, e. g. , Isis Pharmaceuticals, Carlsbad, CA; Sequitor, Inc., Natick, MA.

Such antisense polynucleotides can readily be synthesized using recombinant means, or can be synthesized in vitro. Equipment for such synthesis is sold by several vendors, including Applied Biosystems. The preparation of other oligonucleotides such as phosphorothioates and alkylated derivatives is also well known.

Antisense molecules as used herein include antisense or sense oligonucleotides. Sense oligonucleotides can, e. g. , be employed to block transcription by binding to the anti-sense strand. The antisense and sense oligonucleotide comprise a single-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for cancer molecules. A preferred antisense molecule is for a cancer sequences in the Tables, or for a ligand or activator thereof. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment generally at least about 14 nucleotides, preferably from about 14-30 nucleotides. The ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, e. g., Stein and Cohen (1988) Cancer Res. 48: 2659-2668; and van der Krol, et al. (1988) BioTechniques 6: 958-976.

RNA interference is a mechanism to suppress gene expression in a sequence specific manner. See, e. g., Brumelkamp, et al. (2002) Sciencexpress (21March2002) ; Sharp (1999) Genes Dev. 13: 139-141; and Cathew (2001) Curr. Op. Cell Biol. 13: 244-248. In mammalian <BR> <BR> cells, short, e. g. , 21 nt, double stranded small interfering RNAs (siRNA) have been shown to be

effective at inducing an RNAi response. See, e. g. , Elbashir, et al. (2001) Nature 411: 494-498.

The mechanism may be used to downregulate expression levels of identified genes, e. g., treatment of or validation of relevance to disease.

Ribozymes In addition to antisense polynucleotides, ribozymes can be used to target and inhibit transcription of cancer-associated nucleotide sequences. A ribozyme is an RNA molecule that catalytically cleaves other RNA molecules. Different kinds of ribozymes have been described, including group I ribozymes, hammerhead ribozymes, hairpin ribozymes, RNase P, and axhead <BR> <BR> ribozymes (see, e. g. , Castanotto, et al. (1994) Adv. in Pharmacology 25: 289-317 for a general review of the properties of different ribozymes).

The general features of hairpin ribozymes are described, e. g. , in Hampel, et al. (1990) Nucl. Acids Res. 18: 299-304; European Patent Publication No. 0 360 257; U. S. Patent No. <BR> <BR> <P>5,254, 678. Methods of preparation are described in, e. g. , WO 94/26877; Ojwang, et al. (1993) Proc. Natl. Acad. Sci. USA 90: 6340-6344; Yamada, et al. (1994) Human Gene Therapy 1: 39- 45; Leavitt, et al. (1995) Proc. Natl. Acad. Sci. USA 92: 699-703; Leavitt, et al. (1994) Human Gene Therapy 5 : 1151-120 ; and Yamada, et al. (1994) Virology 205 : 121-126.

Polynucleotide modulators of cancer may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors.

Preferably, conjugation of the ligand binding molecule does not substantially interfere with the ability of the ligand binding molecule to bind to its corresponding molecule or receptor, or block entry of the sense or antisense oligonucleotide or its conjugated version into the cell.

Alternatively, a polynucleotide modulator of cancer may be introduced into a cell containing the <BR> <BR> target nucleic acid sequence, e. g. , by formation of an polynucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of treatment.

Thus, in one embodiment, methods of modulating cancer in cells or organisms are provided. In one embodiment, the methods comprise administering to a cell an anti-cancer antibody that reduces or eliminates the biological activity of an endogenous cancer protein.

Alternatively, the methods comprise administering to a cell or organism a recombinant nucleic

acid encoding a cancer protein. This may be accomplished in any number of ways. In a <BR> <BR> preferred embodiment, e. g. , when the cancer sequence is down-regulated in cancer, such state may be reversed by increasing the amount of cancer gene product in the cell. This can be accomplished, e. g. , by overexpressing the endogenous cancer gene or administering a gene encoding the cancer sequence, using known gene-therapy techniques. In a preferred embodiment, the gene therapy techniques include the incorporation of the exogenous gene using <BR> <BR> enhanced homologous recombination (EHR), e. g. , as described in PCT/US93/0386.<BR> <P>Alternatively, e. g. , when the cancer sequence is up-regulated in cancer, the activity of the<BR> endogenous cancer gene is decreased, e. g. , by the administration of a cancer antisense or other inhibitor, e. g., RNAi.

In one embodiment, the cancer proteins of the present invention may be used to generate polyclonal and monoclonal antibodies to cancer proteins. Similarly, the cancer proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify cancer antibodies useful for production, diagnostic, or therapeutic purposes. In a preferred embodiment, the antibodies are generated to epitopes unique to a cancer protein; that is, the antibodies show little or no cross-reactivity to other proteins. The cancer antibodies may be coupled to standard affinity chromatography columns and used to purify cancer proteins. The antibodies may also be used as blocking polypeptides, as outlined above, since they will specifically bind to the cancer protein.

Methods of identifying variant cancer-associated sequences Without being bound by theory, expression of various cancer sequences is correlated with cancer. Accordingly, disorders based on mutant or variant cancer genes may be determined. In one embodiment, the invention provides methods for identifying cells containing variant cancer genes, e. g. , determining all or part of the sequence of at least one endogenous cancer gene in a cell. In a preferred embodiment, the invention provides methods <BR> <BR> of identifying the cancer genotype of an individual, e. g. , determining all or part of the sequence of at least one cancer gene of the individual. This is generally done in at least one tissue of the individual, and may include the evaluation of a number of tissues or different samples of the same tissue. The method may include comparing the sequence of the sequenced cancer gene to a known cancer gene, e. g. , a wild-type gene.

The sequence of all or part of the cancer gene can then be compared to the sequence of a known cancer gene to determine if any differences exist. This can be done using known

homology programs, such as Bestfit, etc. In a preferred embodiment, the presence of a difference in the sequence between the cancer gene of the patient and the known cancer gene correlates with a disease state or a propensity for a disease state, as outlined herein.

In a preferred embodiment, the cancer genes are used as probes to determine the number of copies of the cancer gene in the genome.

In another preferred embodiment, the cancer genes are used as probes to determine the chromosomal localization of the cancer genes. Information such as chromosomal localization finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in the cancer gene locus.

Administration of pharmaceutical and vaccine compositions In one embodiment, a therapeutically effective dose of a cancer protein or modulator thereof, is administered to a patient. By"therapeutically effective dose"herein is meant a dose that produces effects for which it is administered. The exact dose will depend on the purpose of <BR> <BR> the treatment, and will be ascertainable using known techniques. See, e. g. , Ansel, et al. (1999) Pharmaceutical Dosage Forms and Drug Delivery Lippincott; Lieberman (1992) Pharmaceutical Dosage Forms (vols. 1-3) Dekker, ISBN 0824770846,082476918X, 0824712692, 0824716981 ; Lloyd (1999) The Art, Science and Technology of Pharmaceutical Compounding Amer.

Pharmaceut. Assn.; and Pickar (1998) Dosage Calculations Thomson. Adjustments for cancer degradation, systemic versus localized delivery, and rate of new protease synthesis, as well as the age, body weight, general health, sex, diet, time of administration, drug interaction and the severity of the condition may be necessary. U. S. Patent Application No. 09/687,576, further discloses the use of compositions and methods of diagnosis and treatment in cancer.

A"patient"for the purposes of the present invention includes both humans and other animals, particularly mammals. Thus the methods are applicable to both human therapy and veterinary applications. In the preferred embodiment the patient is a mammal, preferably a primate, and in the most preferred embodiment the patient is human.

The administration of the cancer proteins and modulators thereof of the present invention can be done in a variety of ways, including, but not limited to, orally, subcutaneously, intravenously, intranasally, transdermally, intraperitoneally, intramuscularly, intrapulmonary, vaginally, rectally, or intraocularly. In some instances, e. g. , in the treatment of wounds and inflammation, the cancer proteins and modulators may be directly applied as a solution or spray.

The pharmaceutical compositions of the present invention comprise a cancer protein in a form suitable for administration to a patient. In the preferred embodiment, the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts. "Pharmaceutically acceptable acid addition salt"refers to those salts that retain the biological effectiveness of the free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic <BR> <BR> acid, and the like. "Pharmaceutically acceptable base addition salts"include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts, and the like. Particularly preferred are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.

The pharmaceutical compositions may also include one or more of the following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol.

The pharmaceutical compositions can be administered in a variety of unit dosage forms depending upon the method of administration. For example, unit dosage forms suitable for oral administration include, but are not limited to, powder, tablets, pills, capsules and lozenges. It is <BR> <BR> recognized that cancer protein modulators (e. g. , antibodies, antisense constructs, ribozymes,<BR> small organic molecules, etc. ) when administered orally, should be protected from digestion.

This is typically accomplished either by complexing the molecule (s) with a composition to render it resistant to acidic and enzymatic hydrolysis, or by packaging the molecule (s) in an appropriately resistant carrier, such as a liposome or a protection barrier. Means of protecting agents from digestion are available.

The compositions for administration will commonly comprise a cancer protein modulator dissolved in a pharmaceutically acceptable carrier, preferably an aqueous carrier. A <BR> <BR> variety of aqueous carriers can be used, e. g. , buffered saline and the like. These solutions are sterile and generally free of undesirable matter. These compositions may be sterilized by conventional, well known sterilization techniques. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents, and the like, <BR> <BR> e. g. , sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate, and the like. The concentration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight, and the like in accordance <BR> <BR> with the particular mode of administration selected and the patient's needs (e. g. , (1980)<BR> Remington's Pharmaceutical Science (18th ed. ) Mack, and Hardman and Limbird (eds. 2001)<BR> Goodman and Gilman : The Pharmacologial Basis of Therapeutics (10th ed. ) McGraw-Hill.

Thus, a typical pharmaceutical composition for intravenous administration would be about 0.1 to 10 mg per patient per day. Dosages from 0.1 up to about 100 mg per patient per day may be used, particularly when the drug is administered to a secluded site and not into the blood stream, such as into a body cavity or into a lumen of an organ. Substantially higher dosages are possible in topical administration. Actual methods for preparing parenterally administrable compositions will be known or apparent.

The compositions containing modulators of cancer proteins can be administered for therapeutic or prophylactic treatments. In therapeutic applications, compositions are <BR> <BR> administered to a patient suffering from a disease (e. g. , a cancer) in an amount sufficient to cure or at least partially arrest the disease and its complications. An amount adequate to accomplish <BR> <BR> this is defined as a"therapeutically effective dose. "Amounts effective for this use will depend upon the severity of the disease and the general state of the patient's health. Single or multiple administrations of the compositions may be administered depending on the dosage and frequency as required and tolerated by the patient. In any event, the composition should provide a sufficient quantity of the agents of this invention to effectively treat the patient. An amount of modulator that is capable of preventing or slowing the development of cancer in a <BR> <BR> mammal is referred to as a"prophylactically effective dose. "The particular dose required for a prophylactic treatment will depend upon the medical condition and history of the mammal, the particular cancer being prevented, as well as other factors such as age, weight, gender,

administration route, efficiency, etc. Such prophylactic treatments may be used, e. g. , in a mammal who has previously had cancer to prevent a recurrence of the cancer, or in a mammal who is suspected of having a significant likelihood of developing cancer based, at least in part, upon gene expression profiles. Vaccine strategies may be used, in either a DNA vaccine form, or protein vaccine.

It will be appreciated that the present cancer protein-modulating compounds can be administered alone or in combination with additional cancer modulating compounds or with <BR> <BR> other therapeutic agent, e. g. , other anti-cancer agents or treatments.<BR> <P>In numerous embodiments, one or more nucleic acids, e. g. , polynucleotides comprising nucleic acid sequences set forth in the Tables, such as RNAi, antisense polynucleotides or ribozymes, will be introduced into cells, in vitro or in vivo. The present invention provides methods, reagents, vectors, and cells useful for expression of cancer-associated polypeptides and nucleic acids using in vitro (cell-free), ex vivo or in vivo (cell or organism-based) recombinant expression systems.

The particular procedure used to introduce the nucleic acids into a host cell for expression of a protein or nucleic acid is application specific. Many procedures for introducing foreign nucleotide sequences into host cells may be used. These include the use of calcium phosphate transfection, spheroplasts, electroporation, liposomes, microinjection, plasma vectors, viral vectors, and other well known methods for introducing cloned genomic DNA, <BR> <BR> cDNA, synthetic DNA, or other foreign genetic material into a host cell (see, e. g. , Berger and Kimmel (1987) Guide to Molecular Cloning Techniques from Methods in Enzymology (vol.

152) Academic Press; Ausubel, et al. (eds. 1999 and supplements) Current Protocols Lippincott; and Sambrook, et al. (2001) Molecular Cloning: A Laboratory Manual (3d ed., Vol. 1-3) CSH Press.

In a preferred embodiment, cancer proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above. Similarly, cancer genes (including both the full-length sequence, partial sequences, or regulatory sequences of the cancer coding regions) can be administered in a gene therapy application. These cancer genes can include inhibitory applications, e. g. , as inhibitory RNA, gene therapy (e. g. , for incorporation into the genome), or antisense compositions.

Cancer polypeptides and polynucleotides can also be administered as vaccine compositions to stimulate HTL, CTL, and antibody responses. Such vaccine compositions can

include, e. g. , lipidated peptides (see, e. g. , Vitiello, et al. (1995) J. Clin. Invest. 95: 341-349), peptide compositions encapsulated in poly (DL-lactide-co-glycolide) ("PLG") microspheres <BR> <BR> (see, e. g. , Eldridge, et al. (1991) Molec. Immunol. 28: 287-294,; Alonso, et al. (1994) Vaccine 12: 299-306; Jones, et al. (1995) Vaccine 13: 675-681), peptide compositions contained in <BR> <BR> immune stimulating complexes (ISCOMS) (see, e. g. , Takahashi, et al. (1990) Nature 344: 873- 875; Hu, et al. (1998) Clin Exp Immunol. 113: 235-243), multiple antigen peptide systems (MAPs) (see, e. g., Tam (1988) Proc. Natl. Acad. Sci. USA 85 : 5409-5413; Tam (1996) J.

Immunol. Methods 196: 17-32), peptides formulated as multivalent peptides; peptides for use in <BR> <BR> ballistic delivery systems, typically crystallized peptides, viral delivery vectors (Perkus, et al. , p.

379, in Kaufmann (ed. 1996) Concepts in Vaccine Development de Gruyter; Chakrabarti, et al.

(1986) Nature 320: 535-537; Hu, et al. (1986) Nature 320: 537-540; Kieny, et al. (1986) Bio/Technology 4: 790-795; Top, et al. (1971) J. Infect. Dis. 124: 148-154 ; Chanda, et al. (1990) Virology 175: 535-547), particles of viral or synthetic origin (see, e. g., Kofler, et al. (1996) J.

Immunol. Methods 192: 25-35; Eldridge, et al. (1993) Sem. Hematol. 30: 16-24; Falo, et al.

(1995) Nature Med. 1: 649-653), adjuvants (Warren, et al. (1986) Annu. Rev. Immunol. 4: 369- 388; Gupta, et al. (1993) Vaccine 11: 293-306), liposomes (Reddy, et al. (1992) J. Immunol.

148 : 1585-1589 ; Rock (1996) Immunol. Todav 17: 131-137), or, naked or particle absorbed cDNA (Ulmer, et al. (1993) Science 259: 1745-1749; Robinson, et al. (1993) Vaccine 11: 957- 960; Shiver, et al. , p 423, in Kaufmann (ed. 1996) Concepts in Vaccine Development de Gruyter; Cease and Berzofsky (1994) Annu. Rev. Immunol. 12: 923-989 ; and Eldridge, et al.

(1993) Sem. Hematol. 30: 16-24). Toxin-targeted delivery technologies, also known as receptor mediated targeting, such as those of Avant Immunotherapeutics, Inc. (Needham, Massachusetts) may also be used.

Vaccine compositions often include adjuvants. Many adjuvants contain a substance designed to protect the antigen from rapid catabolism, such as aluminum hydroxide or mineral oil, and a stimulator of immune responses, such as lipid A, Bortadella pertussis, or Mycobacterium tuberculosis derived proteins. Certain adjuvants are commercially available as, <BR> <BR> e. g. , Freund's Incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detroit, MI) ;<BR> Merck Adjuvant 65 (Merck and Company, Inc. , Rahway, NJ); AS-2 (SmithKline Beecham, Philadelphia, PA); aluminum salts such as aluminum hydroxide gel (alum) or aluminum phosphate; salts of calcium, iron, or zinc; an insoluble suspension of acylated tyrosine; acylated sugars; cationically or anionically derivatized polysaccharides ; polyphosphazenes;

biodegradable microspheres; monophosphoryl lipid A and quil A. Cytokines, such as GM-CSF, interleukin-2, -7, -12, and other like growth factors, may also be used as adjuvants.

Vaccines can be administered as nucleic acid compositions wherein DNA or RNA encoding one or more of the polypeptides, or a fragment thereof, is administered to a patient.

This approach is described, for instance, in Wolff et. al. (1990) Science 247: 1465-1468, as well as U. S. Patent Nos. 5,580, 859; 5, 589, 466; 5,804, 566; 5,739, 118; 5,736, 524; 5,679, 647; WO 98/04720; and in more detail below. Examples of DNA-based delivery technologies include "naked DNA", facilitated (bupivicaine, polymers, peptide-mediated) delivery, cationic lipid complexes, and particle-mediated ("gene gun") or pressure-mediated delivery (see, e. g. , U. S.

Patent No. 5,922, 687).

For therapeutic or prophylactic immunization purposes, the peptides of the invention can be expressed by viral or bacterial vectors. Examples of expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus, e. g., as a vector to express nucleotide sequences that encode cancer polypeptides or polypeptide fragments. Upon introduction into a host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits an immune response. Vaccinia vectors and methods useful in immunization protocols are described in, e. g. , U. S. Patent No. 4,722, 848. Another vector is BCG (Bacille Calmette Guerin). BCG vectors are described in Stover, et al. (1991) Nature 351: 456-460. A wide variety of other vectors are availablel for therapeutic administration or immunization, e. g. , adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like. See, e. g., Shata, et al. (2000) Mol Med Today 6: 66-71; Shedlock, et al. (2000) J. Leukoc. Biol. 68: 793- 806; Hipp, et al. (2000) In Vivo 14: 571-85.

Methods for the use of genes as DNA vaccines are well known, and include placing a cancer gene or portion of a cancer gene under the control of a regulatable promoter or a tissue- specific promoter for expression in a cancer patient. The cancer gene used for DNA vaccines can encode full-length cancer proteins, but more preferably encodes portions of the cancer proteins including peptides derived from the cancer protein. In one embodiment, a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from a cancer gene. For example, cancer-associated genes or sequence encoding sub fragments of a cancer protein are introduced into expression vectors and tested for their immunogenicity in the context of Class I MHC and an ability to generate cytotoxic T cell responses. This procedure

provides for production of cytotoxic T cell responses against cells which present antigen, including intracellular epitopes.

In a preferred embodiment, DNA vaccines include a gene encoding an adjuvant molecule with the DNA vaccine. Such adjuvant molecules include cytokines that increase the immunogenic response to the cancer polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are available.

In another preferred embodiment, cancer genes find use in generating animal models of cancer. When the cancer gene identified is repressed or diminished in cancer tissue, gene therapy technology, e. g. , wherein inhibitory or antisense RNA directed to the cancer gene will also diminish or repress expression of the gene. Animal models of cancer find use in screening for modulators of a cancer-associated sequence or modulators of cancer. Similarly, transgenic animal technology, including gene knockout technology, e. g. , as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence or increased expression of the cancer protein. When desired, tissue-specific expression or knockout of the cancer protein may be necessary.

It is also possible that the cancer protein is overexpressed in cancer. As such, transgenic animals can be generated that overexpress the cancer protein. Depending on the desired expression level, promoters of various strengths can be employed to express the transgene.

Also, the number of copies of the integrated transgene can be determined and compared for a determination of the expression level of the transgene. Animals generated by such methods will find use as animal models of cancer and are additionally useful in screening for modulators to treat cancer.

Kits for Use in Diagnostic and/or Prognostic Applications For use in diagnostic, research, and therapeutic applications suggested above, kits are also provided by the invention. In diagnostic and research applications, such kits may include at least one of the following: assay reagents, buffers, cancer-specific nucleic acids or antibodies, hybridization probes and/or primers, antisense polynucleotides, ribozymes, dominant negative cancer polypeptides or polynucleotides, small molecule inhibitors of cancer-associated sequences etc. A therapeutic product may include sterile saline or another pharmaceutically acceptable emulsion and suspension base.

In addition, the kits may include instructional materials containing instructions (e. g., protocols) for the practice of the methods of this invention. While the instructional materials

typically comprise written or printed materials, they are not limited to such. A medium capable of storing such instructions and communicating them to an end user is contemplated by this invention. Such media include, but are not limited to, electronic storage media (e. g. , magnetic<BR> discs, tapes, cartridges, chips), optical media (e. g. , CD ROM), and the like. Such media may include addresses to internet sites that provide such instructional materials.

The present invention also provides for kits for screening for modulators of cancer- associated sequences. Such kits can be prepared from readily available materials and reagents.

For example, such kits can comprise one or more of the following materials: a cancer-associated polypeptide or polynucleotide, reaction tubes, and instructions for testing cancer-associated activity. Optionally, the kit contains biologically active cancer protein. A wide variety of kits and components can be prepared according to the present invention, depending upon the intended user of the kit and the particular needs of the user. Diagnosis would typically involve evaluation of a plurality of genes or products. The genes will typically be selected based on correlations with important parameters in disease which may be identified in historical or outcome data.

EXAMPLES Example 1: Gene Chip Analysis Molecular profiles of various normal and cancerous tissues were determined and analyzed using gene chips. RNA was isolated and gene chip analysis was performed as described (Glynne, et al. (2000) Nature 403: 672-676; Zhao, et al. (2000) Genes Dev. 14: 981- 993).

Table 1 lists medical conditions, abnormalities, or organs affected by disease, referred to in Tables 2A-68, for which markers have been identified, and other related medical conditions (including various stages and/or metastases) in which those markers will also be useful, e. g., in therapeutic, diagnostic, prognostic, subsetting, vaccine, and other uses. blood vesselslangiogenesis : hemangiomas, lymphangiomas, wound healing, tissue remodeling, psoriasis, ischemic, heart disease, inflammatory diseases (e. g., arthritis, asthma, chronic bronchitis), atherosclerosis, endometriosis, presumed ocular histoplasmosis syndrome, hypoxia, solid tumors, lymphomas, autoimmune diseases (e. g. , RA, SLE, juvenile<BR> chronic arthritis, pigmented villonodular synovites, etc. ), retinal neovascularization syndromes (e. g. , diabetic reUnopathy, macular degeneration, presumed ocular histoplasmosis syndrome, etc.), scleritis/conjunctivitis, hypertrophic scars (keloid), birth control, uterine fibroids bladder carcinoma in situ, papillary carcinomas, transitional cell carcinoma bone marrow : Ewing sarcoma, sarcomas arising from skeletal and extraskeletal connective tissues, including the peripheral nervous system brain: glioblastoma, oligodendroglioma, anablastic astrocytoma, meningioma, medulablastoma, neuroblastoma, ependymoma, schwannoma, craniopharyngioma, pineoblastoma, pineocytoma breast : ductal carcinoma in situ, lobular carcinoma in situ cervix: cancer of the cervix, vagina, or vulva colon/rectum : precancerous colorectal disease (e. g., neoplastic polyps (adenomas), familial adenomatous polyposis, ulcerative colitis), colon cancer, e. g., epithelial tumor (e. g., adenocarcinoma, mucinous adenocarcinoma, signet-ring cell adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, undifferentiated carcinoma, unclassified carcinoma), carinoid tumor (e. g., argentaffin, nonargentaffin, composite), non-epithelial tumor (e. g., leimyo sarcoma, others), inflammatory bowel disease (e. g., ulcerative colitis, Crohn's disease (granulomatous colitis), dysplasia), rectal cancer, cancer of the anal region (e. g. , squamous cell carcinoma, transitional carcinoma, adenocarcinoma, carcinoma, papillary villous carcinoma, mucinous adenocarcinoma, melanoma) esophagus: premalignant or predisposing conditions (e. g., esophagits), squamous cell cancers (e. g., cancers of the head and neck, lung, or cervix), gastrodigestive carcinomas (e. g. , cancers of the stomach, colon, or rectum) fibrosis : lung fibrosis (idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, interstitial pneumonit s, nonspeciEc idiopathic pneumoniUs), chronic obstructive pulmonary disease (e. g. , emphysema, chronic bronchitis), asthma, bronchiectasis, cirrhosis (liver fibrosis), renal fibrosis, scleroderma, wound healing head and neck : tumors of the nasal cavity, paranasal sinuses, nasopharynx, oral cavity, oral pharynx, lip, tarynx, hypopharynx, salivary glands, paragangliomas, esophagus kidney: clear cell (nonpapillary) carcinoma, papillary carcinoma, chromophobe renal carcinoma, hypemephroma, adenocarcinoma, sporadic renal carcinomas, hereditary renal carcinomas (von Hippei-Lindau disease), carcinoma of the renal pelvis, ureteral carcinoma, fibroma, papillary adenoma, angiomyolipoma, oncocytoma leukocytes : acute lymphoblastic teukemiatlymphoma, malignant transformation of immature, precursor B (pre-B) or precursor T (pre-T) lymphocytes, or lymphoblasts, arthritis, inflammation, wound healing liver hepatitis (e. g. , types A, B, C), benign epithelial tumors and tumor bile conditions, primary malignant epithelial tumors, primary malignant mesenchymal tumors, tumors of the gallbladder or bile duct lung : lung cancer, small cell lung carcinoma (oat cell carcinoma), non-small cell carcinomas (e. g. , squamous cell carcinoma, adenocarcinoma, large cell lung carcinoma, carcinoid, granulomatous), fibrosis (idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, intersti6al pneumonitis, nonspecific idiopathic pneumonitis), chronic obstructive pulmonary disease (e. g. , emphysema, chronic bronchitis), asthma, bronchiectasis, esophageal cancer<BR> ovary: ovarian carcinoma (e. g., epithelial (serous tumors, mucinous tumors, endometrioid tumors), germ cell (e. g. , teratomas, choriocarcinomas, polyembryomas, embryomal carcinoma, endodermal sinus tumor, dysgerminoma, gonadoblastoma), stromal carcinomas (e. g., granulosal stromal cell tumors)), fallopian tube carcinoma, peritoneal carcinoma, lelomyoma pancreas: adenocarcinoma, ductal adenocarcinoma, mucinous cyst adenocarcinoma, acinar cell carcinoma, unclassified large cell carcinoma, small cell carcinoma, pancreatoblastoma, duct-ectabc mucin-hypersecreting tumor, mucinous cyst adenoma, papillary cyst'c neoplasm, serous cyst adenoma, diabetes melitis, chronic pancreas prostate: epithelial neoplasms (e. g. , adenocarcinoma, small cell tumors, transitional cell carcinoma, carcinoma in situ, and basal cell carcinoma), carcinosarcoma, non-epithelial neoplasms (e. g., mesenchymal and lymphom), germ cell tumors, prostatic intraepithelial neoplasia (PIN), hormone independent prostate cancer, benign prostate hyperplasia, prostatitis skin/melanoma : melanoma, lentigo (common benign localized hyperplasia of melanocytes), nevocellular nevi (congenital or acquired neoplasm of melanocytes), actinic keratosis (overgrowth of outer layers of skin), basal cell carcinoma, Merkel cell carcinoma, benign fibrous histiocytoma (dermal neoplasms of fibroblasts and histiocytes), dermatofibrosarcoma protuberans (well differentiated fibrosarcoma of the skin), xanthomas (tumor-like collections of foamy histiocytes within the dermis), dermal vascular tumors, seborrheic keratoses (benign tumor), acanthosis nigricans (benign or malignant hyperplasia and hyperpigmentation of skin), and squamous cell carcinomas of the skin, lung, cervix, esophagus, uterus, head, neck, or bladder stomach : adenocarcinoma, squamous cell carcinoma, adenoacanthoma, carcinoid, leiomyosarcoma, gastritis (chronic atrophic, H. pylori associated), hyperplastc polyps, lipoma, leiomyoma, esophageal adenocarcinomas testicles : germ cell tumors (including seminomas, embryonal carcinomas, teratomas, choriocarcinomas, yolk sac tumors), sex chord stromal tumors (including Leydig cell tumors, Sertoli cell tumors, and Granulosa cell tumors), germ cell and gonadal stromal elements (e. g., gonadoblastomas), adnexal and paratesticular tumors (e. g., mesotheliomas, soft tissue sarcomas, and adnexal of the rete testes), miscellaneous neoplasms (including carcinoid, lymphom, and cysts) uterus: epithelial tumors (e. g., endometrioid, papillary endometrioid, papillary serous, clear cell, mucinous), mesenchymal tumors (e. g., endometrial stromal sarcoma, leiomyosarcoma, nonspecific sarcomas), mixed tumors (e. g. , malignant mixed mullerian tumors, adenosarcoma) Tables 2B-66C list accession numbers for Pkeys lacking UnigenelD's for Tables 2A-66C, respectively. For each probeset is listed gene cluster number from which oligonucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwisi, Oakland California). Genbank accession numbers for sequences comprising each cluster are listed in the'Accession'column.

Tables 2C-66C list genomic positioning for Pkeys lacking Unigene ID's and accession numbers in Tables 2A-66C, respectively. For each predicted exon is listed genomic sequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

TABLE 2A: ABOUT 1031 GENES UP-REGULATED IN ACUTE LYMPHOCYTIC LEUKEMIA (ALL) Table 2A lists about 1031 genes up-regulated in acute lymphocyfic leukemia (ALL) compared to normal adult tissues. These were selected from 35403 probesets on the Affymetrix/Eos Hu01 GeneChip array such that the ratio of"average"leukemia to"average"normal adult tissues was greater than or equal to 1.7. The'average'leukemia level was set to the 75 percentile amongst various ALL samples. The"average"normal adult tissue level was set to the û5 pencentile amongst various non-malignant tissues. In order to remove gene-specific background levels of non-specific hybridization, the 7. 5t percentile value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated.

Pkey: Unique Eos probeset identifier number ExAccn: Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title RI : Ratio of leukemia to normal body tissue Pkey ExAcc UniGeneID UniGeneTitle R1 100458 S74019 Hs. 247979 pre-B Iymphocyte gene 1 46. 8 113089 T40707 Hs. 270862 ESTs 20. 4 106956 R06428 Hs. 226351 ESTs 15. 8 101447 M21305 gb : Human alpha satellite and satellite 3 13. 8 113009 T23699 Hs. 7246 ESTs 12. 5 126947 Z40778 Hs. 191837 ESTs 11. 4 100893 BE245294 Hs. 180789 S164 protein 11. 1 101050 AU077324 Hs. 1832 neuropeptideY 11. 0 132114 NM_006152 Hs. 40202 lymphoid-resticted membrane protein 10. 7

101304 AA001021 Hs. 6685 thyroid hormone receptor interactor 8 10. 4 105667 AA767526 Hs. 22030 paired box gene 5 (B cell lineage specif 9. 1 112727 T91029 Hs. 15069 ESTs 9. 0 109788 T79971 Hs. 12432 Homosapiensclone24407mRNAsequence 8. 7 113374 T79925 Hs. 269165 ESTs, Weakly similar to ALU1 HUMAN ALU 5 7. 8 130466 W19744 Hs. 180059 Homo sapiens cDNA FLJ20653 fis, clone KA 7. 7 109384 AA219172 Hs. 86849 ESTs 7. 6 112602 AW004045 Hs. 203365 ESTs 6. 6 125278 AI218439 Hs. 129998 enhancerofpolycombi 6. 5 112167 N99591 Hs. 25587 ESTs, Weakly similar to T00329 hypotheti 6. 4 116355 AA789133 Hs. 88650 ESTs 5. 8 123440 A1733692 Hs. 112488 ESTs 5. 5 100918 AK001335 Hs. 31137 protein tyrosine phosphatase, receptor t 5. 4 101879 AA176374 Hs. 243886 ñuclear autoantigenic spemm protein (his 5. 4 109260 AW978515 Hs. 131915 KIAA0863 protein 5. 4 129213 AI146494 Hs. 109525 ESTs, Weakly similar to IRX2_HUMAN IROQU 5. 4 120809 AA346495 gb : EST52657 Fetal heart 11 Homo sapiens 5. 4 105498 H68279 Hs. 24937 transformer-2 alpha (htra-2 alpha) 5. 1 114840 AA447591 Hs. 87359 ESTs, HighlysimilartoRB18_HUMANRAS-R 5. 0 103304 BE561801 Hs. 2484 T-cell leukemiallymphoma 1A 4. 9 113983 W87415 Hs. 55296 HLA-B associated transcript-1 4. 8 115844 A1373062 Hs. 332938 hypothetical protein MGC5370 4. 8 120712 AF193339 Hs. 102506 eukaryotictransiationinitiahonfactor 4. 8 107794 AA019255 gb : ze56e10. s1 Scares retina N2b4HR Homo 4. 7 135101 U82275 Hs. 94498 leukocyte immunoglobulin-like receptor, 4. 6 129898 A1672731 Hs. 13256 ESTs 4. 6 113494 T91451 Hs. 86538 ESTs 4. 6 115004 AA329340 Hs. 4867 mannosyl (a. pha-1, 3-)-glycopnotein beta-4. 5 113074 AK001335 Hs. 31137 protein tyrosine phosphatase, receptor t 4. 5 112326 R55822 Hs. 4268 ESTs 4. 4 105169 BE245294 Hs. 180789 S164 protein 4. 4 117048 H89732 Hs. 230113 EST 4. 3 123133 AA487264 Hs. 154974 Homo sapiens mRNA ; cDNA DKFZp667N064 (fr 4. 3 111394 AA412227 Hs. 16131 hypothetcalproteinFW12876 43 106112 AL117518 Hs. 3686 KIAA0978 protein 4. 2 114414 AW152166 Hs. 182113 ESTs 4. 2 125219 A1804331 Hs99423 ATP-dependentRNAhelicase 4. 2 114995 AA769266 Hs. 193657 ESTs 4. 2 123338 AA504249 Hs. 187585 ESTs 4. 1 126666 AA648886 Hs. 151999 ESTs 4. 1 112908 BE281000 Hs. 3530 TLS-associated serine-arginine protein 2 4. 1 116640 X89984 Hs. 211563 B-cell CLL/iymphoma 7A 4. 0 109292 AW975746 Hs. 188662 KIAA1702 protein 4. 0 131724 AK001335 Hs. 31137 protein tyrosine phosphatase, receptor t 4. 0 119772 AJ250839 Hs. 58241 gene for serinelthreonine protein kinase 4. 0 134453 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 4. 0 123562 AA177088 Hs. 190065 ESTs 4. 0 103226 X75042 Hs. 44313 v-rel avian reticuloendotheliosis viral 3. 9 127610 AA960867 Hs. 150271 ESTs, Highly similar to unnamed protein 3. 9 119873 Ai660149 Hs. 44865 lymphoid enhancer-binding factor 1 3. 9 115553 AJ275986 Hs. 71414 transcriptionfactor (SMIF gene) 3. 9 131844 AI419294 Hs. 324342 ESTs 3. 8 123360 AA532718 Hs. 178604 ESTs 3. 8 111180 At798851 Hs. 283108 hemoglobin, gammaG 3. 8 129426 AF077953 Hs. 111323 Protein inhibitor of activated STAT X 3. 8 105434 AA252111 Hs. 15200 ESTs 3. 8 119073 BE245360 Hs. 279477 ESTs 3. 8 127003 AW816515 Hs. 173540 ATPase, Class V, type 10D 3. 7 119325 T51136 Hs. 90489 ESTs 3. 7 115998 AA448488 Hs. 336629 dbosomal protein L44 3. 7 119830 AW054922 Hs. 53478 Homo sapiens cDNA FLJ12366 fis, clone MA 3. 7 104584 AA704538 Hs. 193777 ESTs 3. 6 105212 AA205334 Hs. 324278 Homo sapiens mRNA ; cDNA DKFZp566M063 (f 3. 6 109223 AW000714 Hs. 65818 ESTs 3. 6 112605 R79374 Hs. 29852 ESTs 3. 5 105733 AA767669 Hs. 10242 ESTs 3. 5 120562 BE244580 Hs. 302267 hypothetical protein FLJ10330 3. 5 112268 W39609 Hs. 22003 solute carrier family 6 (neurotransmitte 3. 5 127834 AW301022 Hs. 337631 EST 3. 5 115147 AA745781 Hs. 38399 hypothetical protein MGC2454 3. 5 115185 BE299677 Hs. 105461 hypothetical protein FLJ20357 3. 5 113921 AW976530 Hs. 28355 hypothetical protein FLJ22402 3. 5 115835 AA521410 Hs. 41371 ESTs 3. 5 123503 AW975051 Hs. 293156 ESTs, Weakly ysimilartol78885serine/th 3. 5 128527 AA504583 Hs. 101047 transcriptionfactor3 (E2Aimmunog) obu) 3. 4 128743 R44284 Hs. 2730 heterogeneous nuclearribonucleoprotein 3. 4 117031 H88353 gb : yw21a02. s1 Morion Fetal Cochlea Homo 3. 4 123149 A1734179 Hs. 105676 ESTs 3. 4 102581 AU077228 Hs. 77256 enhancer of zeste (Drosophila) homolog 2 3. 4 103158 BE242587 Hs. 118651 hematopoieticallyexpressedhomeobox 3. 4 107599 AW664072 Hs. 60136 ESTs 3. 4 125556 AB033064 Hs. 334806 KIAA1238 protein 3. 4 103331 A1825463 Hs. 147996 protein kinase, X-linked 3. 4

114387 Al655141 Hs. 107720 ESTs, Weakly similar to A54295 interfer 3. 4 119040 R02394 Hs. 269436 ESTs, Moderately similar to PC4259 feni 3. 4 100305 NM_004941 Hs. 171872 DEAD/H (AspGlu-Ala-AsplHis) boxpolypep 3. 4 129818 T71092 Hs172572 hypothetica. proteinFW20093 3-3 133445 AC005262 Hs. 73797 guanine nucleotide binding protein (G pr 3. 3 132111 AW500857 Hs. 40137 anaphase-promoting complex 1 ; meiotic ch 3. 3 105292 AF128542 Hs. 166846 polymerase (DNA directed), epsilon 3. 3 118397 BE139479 Hs. 161492 ESTs 3. 3 118922 AW206193 Hs. 91065 hypothetical protein OKFZp761B2423 3. 2 132344 AW977189 Hs. 45719 KIAA0823 protein 3. 2 129889 AA810932 Hs. 131899 ESTs, Weakly similar to T00370 hypotheti 3. 2 123670 Ai189844 Hs. 112708 ESTs, ModeratelysimilartoZN91_HUMANZ 3. 2 116291 AW410377 Hs. 41502 hypothetical protein FlJ21276 3. 2 105289 AB020638 Hs. 103000 KIAA0831 protein 3. 2 105583 AA278907 Hs. 3530 TLS-associated serine-arginine protein 3. 2 104796 BE620712 Hs. 33026 hypothetical protein PP2447 3. 2 111657 R07364 Hs. 268667 ESTs, Weaklysimilar aIUMANALU 3. 2 134174 AF283770 Hs. 79630 CD79A antigen (immunoglobulin-associated 3. 2 126077 M78772 Hs. 210836 ESTs 3. 1 133733 AK000476 Hs. 75798 hypothetical protein 3. 1 124847 W07701 Hs. 304177 Homo sapiens clone FLB8503 PRO2286 mRNA, 3. 1 127879 AA768098 Hs. 189079 ESTs 3. 1 113108 AW516695 Hs. 8438 ESTs 3. 1 110343 AW136703 Hs. 17268 ESTs 3. 1 102935 BE561850 Hs. 80506 small nuclear dbonucleoprotein polypept 3. 1 111676 AB040882 Hs. 109778 KIAA1449 protein 3. 1 127311 AA492582 Hs. 322404 hypothetica ! protein MGC4175 3. 1 108830 AA131743 Hs. 193352 ESTs 3. 1 111330 BE247767 Hs. 18166 KIAA0870 protein 3. 1 104246 AF016032 Hs. 201377 lysosomal apyrase-like 1 3. 1 126668 AA011616 Hs. 269877 ESTs 3. 1 124724 H20816 Hs. 112423 HomosapiensmRNA ; CDNA DKFZp58611420 (f 3. 1 114794 A1751157 Hs. 101395 hypothetical protein MGC11352 31 134599 X99226 Hs. 284153 Fanconi anemia, complementation group A 3. 0 130314 NM 014674 Hs. 154332 KIAA0212 gene product 3. 0 100265 D38521 Hs. 112396 K) AA0077 protein 3. 0 115005 At760825 Hs. 111339 ESTs 3. 0 123433 AW450922 Hs. 112478 ESTs 3. 0 127798 AA737068 Hs. 294078 ESTs 3. 0 117403 H84455 Hs. 40639 ESTs 3. 0 107111 A1298448 Hs. 22670 chromodomain helicase DNA binding protei 3. 0 105698 AW957300 Hs. 294142 ESTs, Weakly similar to C55663 oligodend 3. 0 108358 M81933 Hs. 1634 cell division cycle 25A 3. 0 132066 AI929392 Hs. 181195 DnaJ (Hsp40) homolog, subfamily B, membe 2. 9 130303 BE245294 Hs. 180789 S164 protein 2. 9 104596 AF067804 Hs. 15423 hypothetical protein HDCMC04P 2. 9 112197 NM 003655 Hs. 5637 ESTs 2. 9 132809 AF036144 Hs. 5734 meningioma expressed antigen 5 (hyaluron 2. 9 100877 X80821 Hs. 27973 KIAA0874 protein 2. 9 108147 Api972094 Hs. 286221 Homo sapiens cDNA FW13741 hs, clone PL 2. 9 133674 AW851121 Hs. 75497 HomosapienscDNA : FLJ22139 fis, clone H 2. 9 129001 AA443323 Hs. 107812 BPOZprotein 2. 9 131920 BE002320 Hs. 287864 Homo sapiens cDNA FLJ14030 fis, clone HE 2. 9 134709 NM 006290 Hs. 211600 tumor necrosis factor, alpha-induced pro 2. 8 113577 A1300699 Hs. 278937 PR00470 protein 2. 8 115839 BE300266 Hs. 28935 transducin-like enhancer ot split 1, hom 2. 8 129969 N57818 gb : yv59d07. s1 Soares fetal liverspleen 2. 8 128659 AW630087 Hs. 103315 trinucleoUderepeatcontåning 1 2. 8 105011 BE091926 Hs. 16244 mitotic spindle coiled-coil related prot 2. 8 129294 AF172940 Hs. 184542 CGI-127 protein 2. 8 104518 H20816 Hs. 112423 Homo sapiens mRNA ; cDNA DKFZp586. 1420 (f 2. 7 107796 AA058848 Hs. 60797 ESTs 2. 7 106331 AB037742 Hs. 24336 KIAA1321 protein 2. 7 127692 A1021912 Hs. 187983 ESTs 2. 7 131916 AA025976 Hs. 34569 ESTs 2. 7 124971 T23800 Hs. 151001 hypothetical protein FU14728 2. 7 129428 AA256906 Hs. 111364 ESTs, Weakly similar to ubiquitous TPR m 2. 7 118348 AW408586 Hs. 91052 ESTs, Moderately similar to ALU5_HUMAN A 2. 7 113219 T59257 Hs. 269528 ESTs, Moderately similar to ALUB HUMAN A 2. 7 131720 Z68128 Hs. 3109 Rho GTPase activaGng protein 4 2. 7 109593 AW196801 Hs. 6685 thyroid hormone receptor interactor 8 2. 7 135359 AF043722 Hs. 99491 RAS guanyl releasing protein 2 (calcium 2. 7 131689 AB012124 Hs. 30696 transcription factor-like 5 (basic helix 2. 7 117457 N29682 Hs. 44071 ESTs, Weakly similar to ALU5_HUMAN ALU 2. 7 121073 H46199 Hs. 112184 DKFZP586J0619 protein 2. 7 125069 H81306 Hs. 194485 ESTs 2. 7 116456 A1381911 Hs. 334859 KIAA1814 protein 2. 7 124271 AW293223 Hs. 8928 hypothetical protein FLJ20291 2. 7 112369 AW966243 Hs. 4243 hypothetical protein FLJ12650 2. 7 115866 AW062629 Hs. 52081 KIAA0867 protein 2. 7 132543 BE568452 Hs. 5101 proteinregulatorofcytokinesisi 2. 7 124494 N54831 Hs. 271381 ESTs, Weakly similar to 138022 hypothet 2. 7 104799 AA029703 gb : ze95hO8. s1 Soaresfetal-hearLNbHH19W 2. 7

120510 A1796395 Hs. 111377 ESTs 2. 6 129781 AA306090 Hs. 124707 ESTs 2. 6 122698 AA456112 Hs. 99410 ESTs 2. 6 106995 AB023139 Hs. 37892 KIAA0922 protein 2. 6 105502 BE464016 Hs. 238956 ESTs 2. 6 128671 A1885045 Hs. 211586 phosphoinositide-3-kinase, regulatory s 2. 6 107059 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re 2. 6 126502 T10077 Hs. 13453 hypothetical protein FLJ14753 2. 6 129703 BE388665 Hs. 179999 Homo sapiens, clone IMAGE : 3457003, mRNA 2. 6 111219 N68836 Hs. 19247 ESTs, Moderately similar to ALUC_HUMAN 2. 6 133529 W45623 Hs. 74571 ADP-ribosylation factor 1 2. 6 125626 A1038854 Hs. 180789 S164protein 2. 6 111189 N67603 Hs. 272130 ESTs, Weakly similar to S65824 reverse 2. 6 113146 BE151985 Hs. 5722 hypotheXcaproteinFW23316 2. 6 125562 Al494372 Hs. 98968 hypothetical protein FLJ23058 2. 6 102263 U29171 Hs. 75852 casein kinase 1, delta 2. 6 118835 AA535246 Hs. 50852 ESTs 2. 6 103141 X66113 Hs. 75584 polymyosifs/sclerodemmaautoanUgen2 (2. 6 109598 R40515 Hs. 21248 ESTs 2. 6 127262 AA828125 gb : od71a09. siNCl CGAP_Ov2Homosapiens 2. 6 129620 D79338 Hs. 239720 CCR4-NOT transcription complex, subunit 2. 6 125905 A1678638 Hs. 6456 chaperonin containing TCP1, subunit 2 (b 2. 6 123255 AA830335 Hs. 105273 ESTs 2. 6 133160 N54968 Hs. 66309 hypotheticaproteinMGC11061 2. 6 109638 AW977747 Hs. 119120 E3 ubiquitin ligase SMURF1 2. 6 119896 AA731836 Hs. 137319 ESTs 2. 6 134770 M89957 Hs. 89575 CD798 antigen (immunoglobulin-associated 2. 6 119403 AL117554 Hs. 119908 nucleolar protein NOP5/NOP58 2. 6 129563 AF119664 Hs. 27299 transcriptional regulator protein 2. 6 111719 A1655806 Hs. 179262 ESTs 2. 6 103982 AA218558 Hs. 7905 sorting nexin 9 2. 6 125032 T74884 gb : yc58d02. s1 Stratageneliver (937224) 2. 5 131426 AL122045 Hs. 26703 CCR4-NOT transcription complex, subunit 2. 5 131938 AF176085 Hs. 34956 neuralpolypyrimidinetractbindingprot 2. 5 102450 U48251 Hs. 75871 protein kinase C binding protein 1 2. 5 133761 AF041430 Hs. 75922 brain protein 13 2. 5 126339 AA152106 Hs. 4859 cyclinLania-6a 2. 5 118967 A1668670 Hs. 216756 ESTs 2. 5 123110 AA486256 Hs. 193510 EST 2. 5 114092 H81213 Hs. 14825 ESTs, Weakly similar to KIAA1503 protein 2. 5 113247 T63856 Hs. 193430 ESTs, Weakly similar to 2109260A Bcell 2. 5 122024 AA431296 Hs. 139433 ESTs 2. 5 106657 AW854339 Hs. 33476 hypothetical protein FLJ11937 2. 5 126127 N95428 gb : zb80d09. s1 Soares senescent fibrob. as Z5 111836 R58394 Hs. 25119 ESTs, WeaklysimilartoYEX0 YEASTHYPOT 2. 5 121470 AA558958 Hs. 324751 ESTs 2. 5 120132 W57554 Hs. 125019 ESTs 2. 5 107731 AA016086 Hs. 272106 ESTs, Weak. ysimilartol38022hypothef 2. 5 118122 A1186671 Hs. 48008 ESTs 2. 5 106589 AK000933 Hs. 28661 Homo sapiens cDNA FLi 10071 fis, c. one HE 2. 5 129948 A1537162 Hs. 263988 ESTs 2. 5 115652 BE093589 Hs. 38178 hypothetical protein FLJ23468 2. 5 103076 NM_001034 Hs. 75319 ribonucleotide reductase M2 polypeptide 2. 5 131019 W28614 Hs. 306155 chorionic somatomammotropin hormone 1 (p 2. 5 100512 D13317 Hs. 78915 GA-binding protein transcription factor, Z5 105393 AF167570 Hs. 256583 interleukin enhancer binding factor 3, 9 2. 5 100571 L14561 Hs. 78546 ATPase, Ca+ transporting, plasma membra 2. 5 106890 AA489245 Hs. 88500 mitogen-activated protein kinase 8 inte 2. 5 104276 AW965275 Hs. 284288 hqp0256 protein 2. 5 113283 T66813 Hs. 12947 EST 2. 5 118078 N54321 Hs. 47790 EST 2. 5 120796 A1247356 Hs. 96820 ESTs 2. 5 106265 AA412176 Hs. 236463 Homo sapiens mRNA ; cDNA DKFZp58610521 (f 2. 5 102507 U52154 Hs. 193044 potassium inwardly-rectifying channel, s 2. 5 106508 A1205785 Hs. 30348 ESTs 2. 5 104568 AW629981 Hs. 172182 poly (A)-binding protein, cytoplasmic 1 2. 5 103698 AA001021 Hs. 6685 thyroid hormone receptor interactor 8 2. 5 113947 W84768 gb : zh53d03. s1 Soares_fetal iiver_spleen_ 2. 5 132112 AL021938 Hs. 40154 jumonji (mouse) homolog 2. 5 129052 BE275031 Hs. 158210 hypothetical protein MGC2555 2. 4 117265 AA451966 Hs. 43005 RAB9-like protein 24 107834 AA253162 Hs. 40838 ESTs 2. 4 113119 T47910 gb : yb18b11. s1Stratsvqenefeta. spleen (9 2. 4 133726 A1803188 Hs. 252716 oxysterol-binding protein-related protei 2. 4 120548 AA280356 Hs. 187634 ESTs 2. 4 121545 AA412442 Hs. 98132 ESTs 2. 4 131136 AB033099 Hs. 23413 KIAA1273 protein 2. 4 126589 AW027809 Hs. 187698 Homo sapiens cytomegalovirus partial fus 2. 4 115475 AB033085 Hs. 40193 hypotheticalpnoteinKIM1259 2. 4 103760 AA642973 Hs. 183842 ubiquian B 2. 4 127889 A1147408 Hs. 144941 ESTs 2. 4 124457 AK000680 Hs. 266175 phosphoprotein associated with GEMs 2. 4 113721 AF143885 Hs. 18190 EST 2. 4

129079 AK000157 Hs. 108502 hypothetical protein FU20150 2. 4 123530 AA608705 Hs. 187772 ESTs 2. 4 123592 AA805331 Hs. 112637 ESTs 2. 4 113474 R50752 Hs. 23856 hypothetical protein MGC5297 2. 4 116728 F13687 Hs. 227976 EST 2. 4 101759 M80244 Hs. 184601 solute cartier family 7 (cationic amino 2. 4 131686 NM_012296 Hs. 30687 GRB2-associated binding protein 2 2. 4 127841 AW136558 Hs. 125246 ESTs 2. 4 102737 R51790 Hs. 239483 Humandone23933mRNAsequence 2. 4 129673 D38552 Hs. 1191 KIAA0073 protein Z4 133095 BE046490 Hs. 180677 zinc finger protein 162 2. 4 124540 N63232 gb : yz39a12. s1 Morton Fetal Cochlea Homo 2. 4 113609 T93263 Hs. 16875 ESTs, Weakly similar to 823650 retrovir 2. 4 128826 Z40313 Hs. 106330 Homo sapiens clone IMAGE : 23371, mRNAseq 2. 4 129059 AW069534 Hs. 279583 CGI-81 protein Z4 134092 AA218558 Hs. 7905 sorting nexin 9 2. 4 132317 BE262438 Hs. 44592 beta-1, 4 mannosyltransferase 2. 4 135278 AA399542 Hs. 229671 EST, Moderately similar to PEPTIDYL-PROL 2. 4 128468 T23625 Hs. 150580 putative translation initia6on factor 24 127407 AW089514 Hs. 279681 heterogeneous nuclear ribonucleoprotein 2. 4 132342 AW162758 Hs. 45232 ESTs, WeaklysimilartoAW5_HUMANAW S 2. 4 113518 AW367788 Hs. 323954 postmeiotic segregation increased 2-lik 2. 4 100330 AW410976 Hs. 77152 minichromosome maintenance deficient (S. 2. 4 116046 BE395293 Hs. 94491 hypothetical protein FLJ20297 2. 4 123910 AA621262 Hs. 179923 ESTs, Weakly similar to S65657 alpha-1 C-2. 4 101651 AL037111 Hs. 75641 galactose-1-phosphate uridylyltransferas 2. 4 100114 X02308 Hs. 82962 thymidylate synthetase 2. 4 125038 AA812234 Hs. 270134 hypothetical protein FLJ20280 2. 4 135191 X16866 Hs. 301086 cytochrome P450, subfamiiy IID (debrisoq 2. 4 123258 AA490929 Hs. 105274 ESTs, WeaklysimilartoRMS1_HUMANREGUL 2. 4 132380 AW373665 Hs. 46853 ESTs 2. 4 114046 BE018658 Hs. 141003 Homo sapiens cDNA : FLJ21691 fis, clone C 2. 3 133582 BE391579 Hs. 75087 Fas-activated sedne/threonine kinase 2. 3 134839 D63479 Hs. 115907 diacylglycerolkinase, delta (130kD) Z3 105734 A1952797 Hs. 10888 hypothetical protein FLJ21709 2. 3 101086 AA382524 Hs. 250959 histamine 2. 3 118349 N63786 Hs. 94149 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 3 101194 L20971 Hs. 188 phosphodiesterase 4B, cAMP-specific (dun 2. 3 130588 AL030996 Hs. 16411 hypothetical protein LOC57187 2. 3 101875 BE241753 Hs. 74592 special AT-rich sequence binding protein 2. 3 118751 N74210 Hs. 50454 ESTs 2. 3 125174 W51835 Hs. 231082 EST 2. 3 105966 AA142984 Hs. 5344 adaptor-related protein complex 1, gamma 2. 3 104624 AA353125 Hs. 184721 ESTs 2. 3 131263 AU077002 Hs. 24950 regulator of G-protein signalling 5 2. 3 105014 AA121123 Hs. 269267 ESTs, WeaklysimilarbAF1613611 HSPC 2. 3 123423 AA598484 gb : ae38fO4. s1 GesslerWi. mstumorHomos 2. 3 128531 H03721 Hs. 2953 ribosomal protein S15a 2. 3 108876 Api733860 Hs. 191453 ESTs 2. 3 130215 BE301883 Hs. 152707 glioblastomaamplifiedsequence 2. 3 132232 A1522273 Hs. 42640 ESTs 2. 3 132664 A1740461 Hs. 54542 ESTs 2. 3 105991 AA215701 Hs. 186541 ESTs, Weaklysimilartoi38022hypotheti 2. 3 100253 D38024 Hs. 157425 double homeobox, 2 2. 3 105574 AA045281 Hs. 266175 phosphoprotein associated with GEMs 2. 3 100780 BE561958 Hs. 302063 immunoglobulin heavy constant mu 2. 3 134964 A1803516 Hs. 272891 hippocalcin-like protein 4 2. 3 132786 BE083422 Hs. 56851 hypothetical protein MGC2668 Z3 104952 AW076098 Hs. 74316 desmoplakin (DPI, DPII) 2. 3 119127 AA708035 Hs. 12248 ESTs 2. 3 104857 AI920902 Hs. 19058 ESTs, Moderately similar to S65657 alpha 2. 3 107592 AA694264 Hs. 60049 ESTs 2. 3 113378 T80738 Hs. 14757 ESTs 2. 3 129228 U40714 Hs. 239307 tyrosyl-tRNA synthetase 2. 3 106898 AA490069 Hs. 306676 Homo sapiens cDNA FLJ14302 fis, clone PL 2. 3 130734 AW137091 Hs. 18624 KIAA1052 protein 2. 3 125728 AW954565 Hs. 57987 B-cellCLL/iymphoma11B (zincfingerpro 2. 3 113697 T97183 Hs. 17992 Homo sapiens mRNA ; cDNADKFZp434J1726 (f 2. 3 107104 AU076640 Hs. 15243 nucleolar protein 1 (120kD) 2. 3 134267 A1174596 Hs. 196209 RAE1 (RNA export 1, S. pombe) homolog 2. 3 105777 R42755 Hs. 23096 ESTs 2. 3 115306 AA280288 Hs. 88746 ESTs 2. 3 133363 A1866286 Hs. 71962 \ ESTs, Weaklysimi. artoB36293pno. ine-r Z3 129535 AA397972 Hs. 169965 chimerin (chimaerin) 1 2. 3 121520 AA412163 Hs. 164785 ESTs 2. 3 123808 AA620552 gb : ae58g11. s1 Stratagene lung carcinoma 2. 3 105700 AW580830 Hs. 35254 hypothetical protein FLB6421 2. 3 120820 AA347417 Hs. 96869 EST 2. 3 128721 AW403911 Hs. 266175 phosphoprotein associated with GEMs 2. 3 107711 W96141 Hs. 220687 ESTs 2. 3 102564 U59423 Hs. 79067 MAD (mothersagainstdecapentap. evqic, Dr 2. 3 131868 AW408296 Hs. 33532 zinc finger protein 151 (pHZ-67) 2. 3 122333 AA625872 Hs. 98977 ESTs, Moderately similar to T34561 hypot 2. 3

118865 Axa736405 Hs. 54530 ESTs 2. 3 128952 AL043463 Hs. 6755 RaP2 interacting protein 8 2. 3 133772 BE379867 Hs. 76038 isopentenyl-diphosphate delta isomerase 2. 3 111795 Api435437 Hs. 24567 ESTs, WeaklysimilartoKBF3_HUMANNUCL 2. 3 103437 AV655598 Hs. 184211 peptidase (mitochondriaprocessing) bet 2. 3 123060 AA482027 Hs. 142569 ESTs, Weakly similar to 138022 hypotheti 2. 3 125466 R08234 Hs. 180461 ESTs 2. 3 100892 BE245294 Hs. 180789 S164 protein 2. 3 121613 AA416879 Hs. 193195 ESTs, Weakly similar to 2109260A B cell 2. 3 133665 AL036883 Hs. 75450 delta sleep inducing peptide, immunoreac 2. 2 129248 W04606 Hs. 171637 hypothetical protein MGC2628 2. 2 126153 H85692 Hs. 40730 ESTs 2. 2 125590 R23858 Hs. 143375 Homo sapiens, clone IMAGE : 3840937, mRNA, 2. 2 104960 AA558677 Hs. 8928 hypotheXca protein FW20291 2. 2 113941 AA531016 Hs. 22399 hypotheGcal protein FLJ14824 2. 2 112540 R69751 gb : yi40a10. s1 Soares placenta Nb2HP Homo 2. 2 105322 T87179 Hs. 16346 ESTs, WeaklysimilartoS57447HP8RI1-7 2. 2 112003 AW978731 Hs. 301824 hypothetical protein PRO1331 2. 2 134733 N87353 Hs. 89421 CBF1 interacting corepressor 2. 2 114620 AA642974 gb : nr60h01. s1 NCl_CGAF_Lym3Homosapiens 2. 2 123451 Ai793211 Hs. 165372 ESTs, Moderately similar to ALU1 HUMAN A 2. 2 130850 AB040922 Hs. 20237 DKFZP566C134 protein 2. 2 105561 AA262881 Hs. 323836 ESTs, Weakly similar to altemauvely s 2. 2 125957 H41694 gb : yo06b06. r1 Scares adult brain N2b5HB5 2. 2 130362 BE513050 Hs. 279681 heterogeneous nuclearribonucleoprotein 2. 2 122682 AA984531 Hs. 159293 ESTs 2. 2 124250 AA350256 Hs. 323875 EST, Weakly similar to 2109260A 8 cell 2. 2 131392 AA235153 Hs. 26320 TRABID protein 2. 2 128845 AW503976 Hs. 10649 basement membrane-induced gene 2. 2 130453 U80735 Hs. 173854 PAX transcription activation domain inte 2. 2 126973 W46653 Hs. 251928 nuclear pore complex interacting protein 2. 2 103156 BE259039 Hs. 129953 Ewing sarcoma breakpoint region 1 2. 2 103163 AU077018 Hs. 3235 keratin 4 2. 2 109252 BE440157 Hs. 85944 ESTs 2. 2 131163 AA099524 Hs. 23754 ESTs 2. 2 115292 AA279956 Hs. 88672 ESTs 2. 2 122591 A1188219 Hs. 99311 ESTs, Weakly similar to HSJ2_HUMAN DNAJ 2. 2 124977 F04819 Hs. 190452 KIAA0365 gene product 2. 2 103319 X83492 Hs. 82359 tumor necrosis factor receptor superfami 2. 2 100370 D79989 Hs. 184884 KIAA0167 gene product 2. 2 128992 H04150 Hs. 107708 ESTs 2. 2 129928 A1338993 Hs. 134535 ESTs 2. 2 108451 AA079195 gb : zm92h12. s1 ovarian cancer 2. 2 133910 AW835281 Hs. 77500 ubiquitin specific protease 4 (proto-onc 2. 2 106288 AB037742 Hs. 24336 KIAA1321 protein 2. 2 134125 NM_014781 Hs. 50421 KIAA0203 gene product 2. 2 101379 X02994 Hs. 1217 adenosine deaminase 2. 2 112276 R53442 Hs. 26038 ESTs, Weakly similar to 138022 hypothet 2. 2 106251 R12607 Hs. 35101 proline-richGla (G-carboxyglutamicacid 2. 2 125394 BE178502 Hs. 173772 ESTs, Weaklysimilartol78885serine/th 2. 2 103392 X94563 gb : H. sapiens dbilacbp gene exon 1 & 2. 2. 2 112853 T02843 gb : FB11H5 Fetal brain, Stratagene Homo s 2. 2 133195 A1434760 Hs. 279949 KIAA1007 protein 2. 2 135060 AK001887 Hs. 259842 protein kinase, AMP-activated, gamma 2 n 2. 2 131381 M92642 Hs. 26208 collagen, type XVI, alpha 1 2. 2 134104 L35253 Hs. 79107 mitogen-activated protein kinase 14 2. 2 105225 AA211777 gb : zn57dO2. s1 Stratagene muscle 937209 H 2. 2 131320 AA505691 Hs. 145696 splicing factor (CC1. 3) 2. 2 114419 A1248013 Hs. 106532 ESTs, Weakly similar to 138588 reverse t 2. 2 103634 BE541733 Hs. 180877 H3 histone, family 3B (H3. 3B) 2. 2 134624 AF035119 Hs. 8700 deleted in liver cancer 1 2. 2 126524 Z45455 Hs. 182447 heterogeneous nudear nbonucieoprotein 2. 2 115556 AL031778 Hs. 797 nuclear transcription factor Y, alpha 2. 2 111898 R38944 Hs. 183475 Homo sapiens clone 25061 mRNA sequence 2. 2 100415 D86970 Hs. 75822 TGFBI-inducedanti-apoptotic factor 1 2. 2 103898 AA248884 gb : k3517. seq. F Human fetal heart, Lambda 2. 2 129501 A1631811 Hs. 180403 STRIN protein 2. 2 127251 AA936428 Hs. 128638 ESTs 2. 2 100613 X52078 Hs. 101047 transcriptionfactor3 (E2Aimmunog. obul 2. 2 116332 AA491208 Hs. 62620 chromosome 6 open reading frame 1 2. 2 128897 AW979134 Hs. 10700 hypothetical protein 2. 2 111777 AK001100 Hs. 41690 desmocollin 3 2. 2 128604 A1879099 Hs. 102397 GlOT-3forgonadotropininducib. etransc 2. 2 125585 AW298113 Hs. 92909 SON DNA binding protein 2. 2 129584 AV656017 Hs. 184325 CGI-76 protein 2. 2 114461 AA531187 Hs. 126705 ESTs 2. 2 121387 AA405854 gb : zu66g08. s1SoarestestisNHT Homo sap 2. 2 109339 AA314554 Hs. 27774 ESTs, High. ysimilartoAF1613491HSPC0 2. 2 129179 AW969025 Hs. 109154 ESTs 2. 2 106711 BE390125 Hs. 143187 hypothetical protein 2. 2 106424 H61005 Hs. 37902 ESTs 2. 2 123949 AA621665 Hs. 208957 EST 2. 2 127256 A1738610 Hs. 267967 ESTs, ModeratelYsimilartoALU8_HUMAN 2. 2

104868 AF173867 Hs. 28906 giucocorticoid modulatory element bindin 2. 2 132984 BE539199 Hs. 62112 zinc finger protein 207 2. 2 126383 AB032977 Hs. 6298 KIAA1151 protein 2. 2 130557 H51825 Hs. 268911 ESTs, Weakly similar to S65824 reverse 2. 2 119232 A1655226 Hs. 117659 ESTs, Weakly similar to T46481 hypotheti 2. 2 105715 BE621800 Hs. 29444 putative small membrane protein NID67 2. 2 124691 R05835 Hs. 110153 ESTs 2. 2 113649 N94768 Hs. 16400 ESTs, Weakly similar to KIAAI 435 protein 2. 2 117040 AW970600 Hs. 303261 ESTs 2. 2 128767 M85169 Hs. 1050 pleckstrin homology, Sec7 and coiled/coi 2. 2 120602 AA808018 Hs. 109302 ESTs 2. 2 107182 A1311782 Hs. 20013 GCIP-interacting protein p29 2. 2 107357 U63973 Hs. 103501 rhodopsin kinase 2. 2 125499 H10543 gb : ym04c06. r1 Soares infant brain 1 NIB H 2. 1 126872 AW450979 gb : Ul-H-BI3-ala-a-12-0-Ul. s1 NCI_CGAP_Su 2. 1 113233 T61955 Hs. 279867 CGI-59 protein 2. 1 128367 AW611791 Hs. 150742 ESTs 2. 1 127432 AW067708 Hs. 170311 heterogeneous nuclearribonucleoprotein 2. 1 114021 AW235215 Hs. 16145 ESTs 2. 1 104455 AL110261 Hs. 157211 DKFZP586B0621 protein 2. 1 134966 AW402389 Hs. 920 modulator recognition factor 1 2. 1 129765 M86933 Hs. 1238 amelogenin (Y chromosome) 2. 1 133461 NM 000762 Hs. 334345 cytochrome P450, subfamily IIA (phenobar 2. 1 109639 AA082650 Hs. 6217 Homo sapiens cDNA FLJ12521 fis, clone NT 2. 1 129794 AF161399 Hs. 23259 hypothetical protein FLJ13433 2. 1 134869 AL157518 Hs. 90421 PR02463 protein 2. 1 110256 H63947 Hs. 237955 RAB7, member RAS oncogene family 2. 1 128817 BE395776 Hs. 168640 ankylosis, progressive (mouse) homolog 2. 1 120906 NM_000734 Hs. 97087 CD3Z antigen, zeta polypeptide (TiT3 com 2. 1 134354 M90391 Hs. 82127 interleukin 16 (lymphocyte chemoattracta 2. 1 106048 AW883367 Hs. 301732 hypothetical protein MGC5306 2. 1 128352 AW137413 Hs. 169942 ESTs 2. 1 115348 AA281562 Hs. 292100 ESTs. 2. 1 123474 AA599209 gb : ag34b11. s1JiabonemanrowstromaHom 2. 1 107121 AB015427 Hs. 250493 zinc finger protein 219 2. 1 118509 N22617 Hs. 43228 HomosapienscDNAFW11835fis, cloneHE 2. 1 135051 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 2. 1 109442 AW296134 Hs. 86999 ESTs, WeaklysimilartoS65657alpha-1C-2. 1 126661 AA009835 Hs. 269521 ESTs 2. 1 129270 AA357185 Hs. 109918 ras homolog gene family, member H 2. 1 125568 AW615396 Hs. 105613 ESTs 2. 1 132867 AF226667 Hs. 58553 CTP synthase 11 2. 1 124656 AW297702 Hs. 102915 ESTs 2. 1 128954 AA346839 Hs. 209100 DKFZP434C171 protein 2. 1 132985 AL045579 Hs. 62113 KIAA0717 protein 2. 1 119247 BE269047 Hs. 65234 hypothetical protein FLJ20596 2. 1 106686 N66397 Hs. 334825 Homo sapiens cDNA FLJ14752 fis, clone NT 2. 1 131009 AF169802 Hs. 22142 cytochrome b5 reductase b5R. 2 2. 1 112170 BE246743 Hs. 288529 hypothetical protein FLJ22635 2. 1 130755 BE293520 Hs. 18910 prostate cancer overexpressed gene 1 2. 1 117357 N24829 gb : yx98h12. s1 Soaresme. anocyte2NbHMHo 2. 1 101613 M24283 Hs. 168383 intercellular adhesion molecule 1 (CD54) 2. 1 127644 N88858 Hs. 155101 ATPsynthase, H+transporting, mitochond 2. 1 101183 AA442324 Hs. 795 H2A histone family, member 0 2. 1 100420 D86983 Hs. 118893 Melanoma associated gene 2. 1 129879 AK001696 Hs. 13109 Ran binding protein 11 2. 1 122311 NM_014913 Hs. 131915 KIAA0863protein 2. 1 130566 R85474 Hs. 16073 ESTs 2. 1 113517 A1874223 Hs. 293560 ESTs 2. 1 115810 AA426026 Hs. 187615 ESTs 2. 1 108743 A1580150 Hs. 71074 ESTs 2. 1 129255 A1961727 Hs. 109804 Hlhistonefamily, memberX 2. 1 120766 AA764879 Hs. 12570 tubulin-specific chaperone d 2. 1 126893 AJ252060 Hs. 26320 TRABID protein 2. 1 115254 AA279024 Hs. 269316 ESTs, Weakly similar to S65657 alpha-1 C 2. 1 105865 BE279383 Hs. 26557 plakophilin 3 2. 1 120999 A1972375 Hs. 29626 hypothetical brain protein my038 2. 1 125636 H12382 Hs. 25119 ESTs, Weakly similar to YEXO_YEAST HYPOT 2. 1 117997 N52090 Hs. 47420 EST 2. 1 104333 D82418 Hs. 29626 hypothetical brain protein my038 2. 1 134315 AA291183 Hs. 81648 hypothetical protein FLJ11021 similarto 2. 1 135332 AW393883 Hs. 98968 hypothetical protein FLJ23058 2. 1 107279 S57296 Hs. 323910 v-erb-b2 avian erythroblastic leukemia 2. 1 133097 W03512 Hs. 6479 hypothetical protein MGC13272 2. 1 112563 AW961220 Hs. 29282 mitogen-activated protein kinase kinase 2. 1 121782 AW452957 Hs. 334698 Homo sapiens, clone MGC : 15203, mRNA, com 2. 1 111567 F12628 Hs. 334786 hypothetical protein MGC16040 2. 1 133912 H42679 Hs. 77522 major histocompatibility complex, class 2. 1 134076 AF086215 gb : Homo sapiens full length insertcDNA 2. 1 116665 F04405 gb : HSC2SB082 normalized infant brain cDN 2. 1 133562 M60721 Hs. 74870 H2. 0 (Drosophila)-like homeo box 1 2. 1 129092 D56365 Hs. 63525 poly (rC)-binding protein 2 2. 1 106869 AW975362 Hs. 292679 ESTs 2. 1

130820 AL353934 Hs. 288798 hypothetical protein FLJ21012 2. 1 126277 AB037847 Hs. 15441 Crm (Cramped Drosophila)-like 2. 1 106392 BE350058 Hs. 36787 chromodomain helicase DNA binding protei Z1 131902 AA180145 Hs. 34348 Homo sapiens mRNA ; cDNA DKFZp434P0235 (f 2. 1 120734 AA299948 gb : EST12544UterustumortHomosapiens 2. 1 113070 AB032977 Hs. 6298 KIAA1151 protein 2. 1 116031 AA452239 Hs. 103329 KIAA0970 protein 2. 1 123869 AA620924 Hs. 112923 EST 2. 1 106145 AA424791 Hs. 5734 meningioma expressed antigen 5 (hyaluron 2. 1 109061 AA160896 gb : zo79cO7. s1 Stratagene pancreas (93720 2. 1 126348 T16243 Hs. 6473 HomosapienscDNAFW13992fis, cloneY7 Z1 133231 AK000517 Hs. 6844 hypotheticalprotein FU20510 2. 1 123132 A1061582 Hs. 324179 Homo sapiens cDNA FW12371 fis, done MA 2. 1 117452 N34687 Hs. 44054 ninein (GSK3B interacting protein) 2. 1 128538 R44214 Hs. 101189 ESTs 21 111945 R40663 Hs. 124944 ESTs 2. 1 119155 R61715 Hs. 310598 ESTs, Moderately similar to AWL-HUMAN 2. 1 124362 AL046406 Hs. 103483 KIAA1798 protein 2. 1 129198 N57532 Hs. 109315 KIAA1415 protein 2. 1 122059 AA431737 Hs. 98749 EST, Moderately similar to T42671 hypoth 2. 1 115643 AA404276 Hs. 123253 hypothetical protein FLJ22009 2. 0 112558 AK001621 Hs. 15921 hypothetical protein FLJ10759 2. 0 115355 AA262292 Hs. 88445 ESTs 2. 0 130724 AK001507 Hs. 306084 HomosapienscloneFLB6914PRO1821 mRNA, 2. 0 125360 AW898892 Hs. 189741 ESTs 2. 0 104926 BE298808 Hs. 33363 DKFZP434N093 protein 2. 0 119468 A1911535 Hs. 6657 hypothetical protein bK1048E9. 5 2. 0 132891 BE267143 Hs. 59271 U2 (RNU2) small nuclear RNA auxillary fac 2. 0 100237 D30715 Hs. 306333 Human PAP (pancreaSEs-associated prot 2. 0 105335 AW291165 Hs. 25447 ESTs 2. 0 106727 AA357001 Hs. 34045 hypothetical protein FLJ20764 2. 0 126053 H64450 gb : yu62dO1. r1 Weizmann Olfactory Epithel 2. 0 115084 BE383668 Hs. 42484 hypothetical protein FLJ 10618 2. 0 128408 A1183407 Hs. 143704 EST 2. 0 132311 Api765559 Hs. 20072 myosin regulatory light chain interactin 2. 0 113626 T94318 Hs. 17359 ESTs, Moderately similar to RL44_HUMAN 6 2. 0 116379 AA448588 Hs. 71252 hypothetical protein DKFZp761C169 2. 0 105474 AL134843 Hs. 219614 f-box and leucine-rich repeat protein 11 2. 0 108922 AA115268 Hs. 269263 ESTs 2. 0 123720 AA609734 Hs. 112755 EST 2. 0 128902 AA036637 Hs. 107052 ESTs 2. 0 113226 A1821008 Hs. 10697 ESTs 2. 0 106798 BE252749 Hs. 20558 hypothetical protein FLJ20345 2. 0 106665 BE090009 Hs. 323164 hypothetical protein MGC2217 2. 0 105952 A1767152 Hs. 181400 ESTs, Weaklysimilartol78885serine/th 2. 0 127248 AA364195 gb : EST75015 Pineal gland 11 Homo sapiens 2. 0 112972 Api684745 Hs. 165983 hypothetical C2H2 zinc finger protein FL 2. 0 128148 AA918175 Hs. 126637 ESTs 2. 0 116176 AA311152 Hs. 288708 hypothetical protein FLJ21562 2. 0 126457 AA007489 Hs. 50382 ESTs 2. 0 112610 AW500106 Hs. 23643 serinelthreonine protein kinase MASK 2. 0 109249 AA194730 Hs. 268189 hypotheticai protein FLJ20436 2. 0 121292 AA401807 gb : zv65f11. s1 Soares_tota. fetus_Nb2HF8_ 2. 0 128605 AW058113 Hs. 102402 Mad4 homolog 2. 0 127705 AJ003322 gb : AJ003322 Selected chromosome 21 cDNA 2. 0 134674 AF219139 Hs. 87726 KIAA0154 protein ; ADP-ribosylationfacto 2. 0 107529 BE515065 Hs. 296585 nucleolarprotein (KKElDrepeaq 2. 0 116411 AA608897 Hs. 321618 hypothetical protein FLJ12525 2. 0 111576 T88827 Hs. 15489 ESTs 2. 0 127002 AL353940 Hs. 24979 hypotheticalprotein DKFZp761P1010 2. 0 112662 R85436 Hs. 268814 ESTs 2. 0 126250 AL050391 Hs. 321247 Homo sapiens mRNA ; cDNADKFZp586A181 (fr 2. 0 101045 J05614 gb : Human proliferating cell nuclear an6 2. 0 117186 H98988 Hs. 42612 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 0 122110 AI123000 Hs. 301240 me) 1 receptor (alpha melanocyt 2. 0 119849 A1074585 Hs. 58440 ESTs 2. 0 124395 N29963 Hs. 272095 ESTs, Weakly similar to 138022 hypotheti 2. 0 131600 NM 004377 Hs. 29331 carnitine palmitoyltransferase 1, muscle 2. 0 112774 R95770 Hs. 35455 ESTs 2. 0 109751 AB033492 Hs. 6679 hHDC for homolog of Drosophila headcase 2. 0 102377 U40343 Hs. 29656 cyclin-dependent kinase inhibitor 2D (p1 2. 0 115197 R18656 Hs. 6749 ESTs 2. 0 102808 BE242818 Hs. 179606 nuclear RNA helicase, DECD variant of DE 2. 0 128869 AA768242 Hs. 80618 hypothetical protein 2. 0 111229 AW389845 Hs. 110855 ESTs 2. 0 129330 AL079310 Hs. 92260 high-mobility group protein 2-like 1 2. 0 105448 NM 001186 Hs. 154276 BTB and CNC homology 1, basic leucine zi 2. 0 127391 AW380893 Hs. 11039 hypothetical protein MGC2722 2. 0 102337 A1814663 Hs. 170133 forkhead box 01A (rhabdomyosarcoma) 2. 0 121897 AA427419 Hs. 229162 EST, Weakly similar to ZN91_HUMAN ZINC 20 107902 AA026627 Hs. 61358 ESTs 2. 0 129340 H75334 Hs. 11050 F-box only protein 9 2. 0 101097 BE245301 Hs. 89414 chemokine (C-X-C motif), receptor 4 (fus 2. 0

124864 AW970168 Hs. 185706 ESTs 2. 0 118485 AA508515 Hs. 291049 ESTs 2. 0 116715 AL117440 Hs. 170263 tumorproteinp53-bindingprotein, 1 2. 0 130743 AL049266 Hs. 18724 Homo sapiens mRNA ; cDNA DKFZp564F093 (fr 2. 0 118677 AW971146 Hs. 293187 ESTs 2. 0 100020 2. 0 123252 AW968776 Hs. 287586 Homo sapiens cDNA FLJ13648 fis, clone PL 2. 0 134977 AL044963 Hs. 306121 leukocyte receptor cluster (LRC) encoded 2. 0 115334 AA702972 Hs. 65300 ESTs 2. 0 111790 AW769683 Hs. 6734 ESTs, Weakly similar to S26650 DNA-bindi 2. 0 129101 NM013403Hs. 108665 zinedin 2. 0 132676 N92589 Hs. 261038 ESTs, Weakly similar to 138022 hypothet 2. 0 111018 AI287912 Hs. 3628 mitogen-æüvatedpnoteinkinasekinase 2. 0 105933 AF078544 Hs. 194686 solute carder family 25 (mitochonddal 2. 0 110679 AA004798 Hs. 108311 ESTs, Weakly similar to T00351 hypotheti 2. 0 120861 AA350394 Hs. 96952 ESTs. 2. 0 132430 AW973652 Hs. 283105 ESTs 2. 0 115026 AA251972 Hs. 188718 ESTs 2. 0 128660 AA011597 Hs. 177398 ESTs 2. 0 134554 A1184316 Hs. 85273 retinoblastoma-binding protein 6 2. 0 109592 A1198059 Hs. 26370 ESTs 2. 0 123636 AA609263 gb : af13c08. s1SoarestestsNHT Homo sap 2. 0 132610 AA160511 Hs. 5326 amino acid system N transporter 2 ; porcu 2. 0 122652 AA454641 gb : zx99d05. s1 Soares_NhHMPu S1 Homosapi 2. 0 120467 AW292562 Hs. 187628 ESTs 2. 0 126046 AA804957 Hs. 119840 ESTs 2. 0 128179 AW293689 Hs. 127116 ESTs 2. 0 123349 AB033042 Hs. 29679 cofactor required for Sp1 transcriptiona 2. 0 106208 AK001674 Hs. 22630 cofactor required for Sp1 transcriptiona 2. 0 125832 AA628600 Hs. 117587 ESTs 2. 0 133317 AC005258 Hs. 70830 U6 snRNA-associated Sm-like protein LSm7 2. 0 132886 AW978168 Hs. 5912 F-box only protein 7 2. 0 127447 AA386192 Hs. 193482 Homo sapiens cDNA FLJ11903 fis, clone HE 2. 0 133149 AA370045 Hs. 6607 AXIN1 up-regulated 2. 0 120468 AW967675 Hs. 96487 ESTs, Highly similar to S08228 ribosomal 2. 0 106487 A1697340 Hs. 135265 Homo sapiens clone FLB8436 PR02277 mRNA, 2. 0 126770 A1292320 Hs. 81361 heterogeneous nuclearribonucleoprotein 2. 0 120592 AA830664 Hs. 143974 ESTs 2. 0 100944 L07518 Hs. 159593 mucin 6, gastric 2. 0 101887 AW967413 Hs. 83958 transducin-likeenhancerofsplit4, hom 2. 0 125324 R07785 gb : yf15c06. ri Soaresfetalliverspleen 2. 0 133906 BE386038 Hs. 77492 heterogeneous nuclear ribonucleoprotein 2. 0 113408 NM 005908 Hs. 115945 mannosidase, beta A, lysosomal 2. 0 115613 AW136951 Hs. 173946 hypotheticalproteinFW10436 2. 0 107468 AA740979 Hs. 91389 ESTs 2. 0 100554 M95923 gb : Human 12-lipoxygenase mRNA, partial c 2. 0 120476 Nom014922 Hs. 104305 death effectorfilament-forming Ced-4-li 2. 0 117160 AA322302 Hs. 183302 PCTAIRE protein kinase 2 2. 0 115582 AW245047 Hs. 136164 cutaneousTcelllymphoma-associatedtu 2. 0 125536 F08266 Hs. 77948 ESTs, WeaklysimilartoALU1 HUMANALUS 2. 0 100842 U05597 gb : Human anion exchanger 3 cardiac isofo 2. 0 133207 A1561173 Hs. 67688 ESTs 2. 0 122053 AI637498 Hs. 98745 ESTs 2. 0 121080 AA617830 Hs. 28310 ESTs 2. 0 113316 T70318 Hs. 268581 ESTs 2. 0 113137 AW952129 Hs. 293225 ESTs, Weakly similar to FLDED-1 [H. sapie 1. 9 100416 AW505086 Hs. 196914 minorhistocompatibi. ityanUgenHA-1 1. 9 133975 C18356 Hs. 295944 tissue factor pathway inhibitor 2 1. 9 103872 A1816078 Hs. 21756 translation factor suit homolog 1. 9 132439 AK001942 Hs. 4863 hypothetical protein DKFZp566A1524 1. 9 126082 H81188 Hs. 269571 ESTs 1. 9 124677 R01073 gb : ye84c03. s1 Soares fetal liver spleen 1. 9 123385 BE149685 Hs. 17767 KIAA1554 protein 1. 9 103138 X65965 gb : H. sapiens SOD-2 gene for manganese su 1. 9 104867 AA278898 Hs. 225979 hypothetical protein similar to small G 1. 9 128668 A1754363 Hs. 103422 Homo sapiens cDNA FLJ14630 fis, clone NT 1. 9 125826 M20681 Hs. 7594 solute carrier family 2 (facilitated glu 1. 9 113701 T97301 Hs. 18026 ESTs 1. 9 134447 M58603 Hs. 83428 nuclear factor of kappa light polypeptid 1. 9 128895 AW467000 Hs. 106985 ESTs 1. 9 112719 Ai200957 Hs. 19301 Homo sapiens, Similar to Nedd-4-like ubi 1. 9 102552 NM 005426 Hs. 44585 tumor protein binding protein, 2 1. 9 131186 Z70200 Hs. 246112 KIAA0788 protein 1. 9 133347 BE257758 Hs. 71475 acid cluster protein 33 1. 9 133388 AW245631 Hs. 182447 heterogeneous nuclearribonucleoprotein 1. 9 112266 A1652534 Hs. 25934 ESTs, WeaklysimilartoHSHU11 histoneH 1. 9 100336 N76101 Hs. 8127 KIAA0144 gene product 1. 9 113479 A1023133 Hs. 10739 ESTs 1. 9 135231 BE613615 Hs. 74280 hypothetical protein FLJ22237 1. 9 123783 AA610112 gb : af19g05. s1 Soares_total_fetus_Nb2HF8_ 1. 9 113016 NM 014007 Hs. 127649 KIAA0414 protein 1. 9 132761 Api815537 Hs. 323502 nuclear RNA export factor 1 1. 9 128536 AW955065 Hs. 101150 Homo sapiens, clone IMAGE : 4054156, mRNA, 1. 9

126663 AW518478 Hs. 181297 ESTs 1. 9 103973 AA305729 Hs. 18272 amino acid transporter system A1 1. 9 106742 AW591428 Hs. 27556 hypothetical protein FLJ22405 1. 9 129793 AW207000 Hs. 126857 Homo sapiens cDNA FLJ12936 fis, clone NT 1. 9 105888 AW970672 Hs. 9247 protein kinase, AMP-activated. alpha 1 c 1. 9 101892 A1825838 Hs. 75206 protein phosphatase 3 (formerly 2B), cat 1. 9 125511 AJ271379 Hs. 76194 ribosomal protein S5 1. 9 126751 At378328 Hs. 77256 enhancer of zeste (Drosophila) homolog 2 1. 9 129111 AL080155 Hs. 226372 DKFZP434J154 protein 1. 9 128750 T80270 Hs. 104788 hypothetical protein LOC55565 1. 9 133531 BE276738 Hs. 74578 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 1. 9 125704 R55094 Hs. 26239 Human DNA sequence from clone RP11-438B2 1. 9 100157 D14661 Hs. 119 Wilms'tumour 1-associaUng protein 1. 9 125845 AK001440 Hs. 131840 hypothetical protein FU10578 1. 9 134682 AW882645 Hs. 88044 sprouty (Drosophila) homolog 1 (antagoni 1. 9 106565 NM_014892 Hs. 227602 KIAA1116 protein 1. 9 106706 AB037810 Hs. 18760 KIAA1389 protein 1. 9 125761 R68351 gb : yh99bO3. r1 Scares placenta Nb2HP Homo 1. 9 116470 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 1. 9 123264 A1681270 Hs. 99824 BCE-1 protein 1. 9 126096 F08208 Hs. 283844 similartorattricarboxylatecanier-li 1. 9 104995 AK001690 Hs. 16390 hypothetical protein FU10035 1. 9 133424 AA350994 Hs. 20281 KIAA1700 1. 9 132450 AA100012 Hs. 48827 hypothetical protein FLJ12085 1. 9 131803 U73737 Hs. 284289 vitiligo-associated protein VIT-1 1. 9 116548 D20433 gb : HUMGS01407 Human promyelocyte Homo sa 1. 9 113815 AA386192 Hs. 193482 Homo sapiens cDNA FLJ11903 fis, clone HE 1. 9 100245 AL039248 Hs. 3094 KIAA0063 gene product 1. 9 113677 Z70200 Hs. 246112 KIAA0788 protein 1. 9 134470 X54942 Hs. 83758 CDC28 protein kinase 2 1. 9 134937 Al251449 Hs. 171939 ESTs 1. 9 134506 AW247364 Hs. 84285 ubiquitin-conjugating enzyme E21 (homolo 1. 9 126469 BE384361 Hs. 182885 ESTs, Weakly similar to JC5024 UDP-galac 1. 9 115261 AA938293 Hs. 60088 hypothetical protein MGC11314 1. 9 125198 W69474 Hs. 323140 ESTs 1. 9 115317 AA303799 Hs. 300141 ribosome protein L39 1. 9 112342 AW410273 Hs. 92614 longevity assurance (LAGt, S. cerevisiae 1. 9 117329 AA524065 Hs. 93670 Homo sapiens cDNA : FLJ22664 fis, clone H 1. 9 116353 AB032966 Hs. 131728 KIAA1140 protein 1. 9 114459 AW445217 Hs. 103362 ESTs 1. 9 133903 X63692 Hs. 77462 DNA (cytosine-5-)-methyltransferase 1 1. 9 116083 AA455706 Hs. 44581 heat shock protein hsp70-related protein 1. 9 130037 A1498631 Hs111334 feniün, lightpolypeptide 1. 9 102273 BE391815 Hs. 75981 ubiquitin specific protease 14 (tRNA-gua 1. 9 120452 AL022328 Hs. 104335 hypotheticalproteinIMAGE3510317 1. 9 116432 BE271922 Hs. 71243 ESTs, Weakly similar to zinc finger prot 1. 9 115916 Al052731 Hs. 91910 ESTs 1. 9 120827 AA382525 Hs. 132967 Human EST clone 122887 mariner transposo 1. 9 129602 AI282193 Hs. 198298 v-src avian sarcoma (Schmidt-Ruppin A-2) 1. 9 105693 BE250951 Hs. 181368 U5 snRNP-specific protein (220 kD), orth 1. 9 102316 U34301 gb : Human nonmuscle myosin heavy chain 11 1. 9 131422 AW607731 Hs. 26670 Human PAC clone RP3-51NN from 22q11. 2-q 1. 9 128434 A1190914 Hs. 143880 ESTs 1. 9 117086 AA581602 Hs. 41840 ESTs 1. 9 102006 AL048967 Hs. 172207 non-POU-domain-containing, octamer-bindi 1. 9 121335 AA404418 gb : zw37eO2. s1 Soares_total_fetus_Nb2HF8_ 1. 9 105905 AA401533 Hs. 19440 ESTs 1. 9 125165 W45350 gb : zc8 h08. s1 PancreaGc Islet Homo sapi 1. 9 109875 H03260 Hs. 30385 ESTs 1. 9 109152 AW380723 Hs. 73451 ESTs, Weakly similar to S55024 nebulin, 1. 9 126203 AK001035 Hs. 130881 B-cell CLLllymphoma 1A (zinc finger pro 1. 9 122530 AW959741 Hs. 40368 adaptor-related protein complex 1, sigma 1. 9 124506 BE273688 Hs. 182447 heterogeneous nuclearribonucleoprotein 1. 9 130525 AA361850 Hs. 322149 Human clone 137308 mRNA, partial cds 1. 9 127226 AL036559 Hs. 3463 ribosome protein S23 1. 9 106465 AA971576 Hs. 225951 topoisomerase-related function protein 4 1. 9 106970 AA521368 Hs. 24252 ESTs 1. 9 134275 A1878910 Hs. 3688 cisplatin resistance-associated overexpr 1. 9 126825 AA100230 gb : z. 81cO1. s1 Stratagene colon (937204) 1. 9 132443 AW246148 Hs. 268371 hypothetical protein FLJ20274 1. 8 104631 AA002064 Hs. 18920 ESTs 1. 8 111468 H62647 Hs. 205481 ESTs 1. 8 114317 AA524839 Hs. 469 succinate dehydrogenase complex, subunit 1. 8 126158 N55989 Hs. 16390 hypothetical protein FLJ10035 1. 8 113782 AK001567 Hs. 311002 Homo sapiens cDNA FLJ10705 fis, clone NT 1. 8 119229 T03229 gb : FB5C2 Fetal brain, Stratagene Homo sa 1. 8 105930 AF016371 Hs. 9880 pepüdy. prolyl isomerase H (cyclophilin 1. 8 127245 AA323958 gb : EST26810 Cerebellum 11 Homo sapiens c 1. 8 100967 BE011845 Hs. 251064 high-mobility group (nonhistone chromoso 1. 8 105149 BE089288 Hs. 8958 HomosapienscDNAFW12024fis, cloneHE 1. 8 104542 R29657 gb : F1-1179D 22 week old human fetal live 1. 8 124236 AF086006 gb : Homo sapiens full length insertcDNA 1. 8 127155 AA284993 gb : zt23e10. r1 SoaresovarytumorNbHOTH 1. 8

126854 AJ275986 Hs. 71414 transcriptionfactor (SMIF gene) 1. 8 107021 AK001342 Hs. 14570 hypothetical protein FU22530 1. 8 110023 AW294701 Hs. 31040 ESTs 1. 8 114899 AK000342 Hs. 77646 Homo sapiens mRNA ; cDNA DKFZp761 M0223 (f 1. 8 127315 AF116622 gb : HomosapienscloneFLB4217mRNAseque 1. 8 110384 H45282 Hs. 268798 ESTs 1. 8 132693 BE244200 Hs. 55075 KIAA0410 gene product 1. 8 127684 M668631 Hs. 32556 KIAA0379 protein 1. 8 127297 AW629485 Hs. 140720 GSK-3 binding protein FRAT2 1. 8 104249 AF004231 Hs. 22405 leukocyte immunoglobulin-like receptor, 1. 8 112652 BE269699 Hs. 235782 so) utecarrierfami ! y21 (organicanion 1. 8 110312 BE256986 Hs. 11896 hypothetical protein FLJ12089 1. 8 100417 NM 014003 Hs. 78054 pre-mRNA splicing factor similar to S. c 1. 8 120532 M262354 Hs. 186648 ESTs, Weakly simi. ar to 138022 hypotheü 1. 8 127629 AA293279 Hs. 29173 hypothetical protein FLJ20515 1. 8 100739 M59287 Hs. 2083 CDC-like kinase 1 1. 8 110636 H72868 Hs. 19110 ESTs 1. 8 132957 BE244044 Hs. 61469 hypothetica) protein 1. 8 115467 A1366784 Hs. 48820 TATA box binding protein (TBP)-associate 1. 8 132161 W31634 Hs. 180799 hypotheUcal protein FLJ22561 1. 8 129510 AW968504 Hs. 123073 CDC2-related protein kinase 7 1. 8 126805 F32658 Hs. 101359 chromosome 6 open reading frame 32 1. 8 129295 U63127 Hs. 110121 SEC7homolog 1. 8 127823 AW972893 Hs. 78869 transcripüonelongafonfætorA (SII), 1. 8 104590 AW373062 Hs. 83623 nuclear receptor subfamily 1, group I, m 1. 8 111959 R40978 Hs. 271498 ESTs, ModeratelysimilarbALU1_HUMANA 1. 8 109303 M199857 Hs. 269291 ESTs 1. 8 112501 M972447 Hs. 288833 Homo sapiens mRNA ; cDNA DKFZp434K087 (fr 1. 8 127303 AA366951 gb : EST77963 Pancreas tumor))) Homo sap ! 1. 8 115982 W92113 gb : zh48eO1. r1 Soares_fetaJiver_spleen_ 1. 8 123331 AA497013 gb : ae32g02. s1 GessierWilmstumorHomos 1. 8 111598 R11505 Hs. 268912 ESTs 1. 8 121643 AA640987 Hs. 193767 ESTs 1. 8 105012 AF098158 Hs. 9329 chromosome 20 open reading frame 1 1. 8 118761 AW799109 Hs. 226755 ESTs 1. 8 128765 AF073310 Hs. 143648 insulin receptor substrate 2 1. 8 118103 AA401733 Hs. 184134 ESTs 1. 8 134595 NM002401 Hs. 29282 mitogen-activated protein kinase kinase 1. 8 134212 AA654353 Hs. 17719 EBP50-PDZ interactor of 64 kD 1. 8 128033 A1248705 Hs. 149321 ESTs 1. 8 126972 NM 016255 Hs. 95260 Autosomal Highly Conserved Protein 1. 8 111122 N63753 Hs. 16492 DKFZP564G2022 protein 1. 8 114798 AA159181 Hs. 54900 senologicaliydefinedcoìoncancerantg 1. 8 106349 AW954310 Hs. 127270 KIAA1545 protein 1. 8 135358 BE622827 Hs. 99486 hypothetical protein FLJ13044 1. 8 116223 AP045458 Hs. 47061 unc-51 (C. elegans)-like kinase 1 1. 8 116654 Z26324 Hs. 79204 ESTs, Weakly similar to 138022 hypotheli 1. 8 124554 N65961 gb : za27dO3. s1 Soaresfetalliverspleen 1. 8 120259 AW014786 Hs. 192742 hypothetical protein FLJ 12785 i. 8 123044 AK001035 Hs. 130881 B-cellCLUlymphoma11A (zincfingerpro 1. 8 125261 W90351 Hs. 110134 ESTs, Highly similar to CREB-binding pro 1. 8 135026 N92165 Hs. 93231 ESTs 1. 8 129951 AL110282 Hs. 268024 Homo sapiens, done) MAGE : 3873720, mRNA 1. 8 125768 AI557486 Hs. 119122 ribosomalproteinL13a 1. 8 114122 R46128 Hs. 12751 ESTs 1. 8 133047 AA310600 Hs. 63657 peptide : N-glycanase similar to yeast PNG 1. 8 133589 L37368 Hs. 75104 RNA-binding protein S1, serine-rich doma 1. 8 130872 U61084 Hs. 226307 phorbolin (similar to apolipoprotein B m 1. 8 133498 BE299587 Hs. 85301 calcium binding protein P22 1. 8 131144 AA305255 Hs. 23528 HSPC038 protein 1. 8 104261 AW248364 Hs. 5409 RNA polymerase I subunit 1. 8 115507 A1083668 Hs. 50601 hypothetical protein MGC10986 1. 8 109073 T05003 Hs. 10056 hypothetical protein FLJ14621 1. 8 115363 AA214618 Hs. 152759 activator of S phase kinase 1. 8 112657 AW844878 Hs. 19769 hypothetical protein MGC4174 1. 8 102960 A1904738 Hs. 76053 DEAD/H (Asp-Giu-Aìa-Asp/His) box polypep 1. 8 125549 R20215 gb : yg18b09. r1Soaresinfantbrain1N) 8H 1. 8 133797 AL133921 Hs. 76272 retinoblastoma-binding protein 2 1. 8 125048 AW440068 Hs. 59425 hypothetical protein FLJ23323 1. 8 103403 X95406 gb : H. sapiens cyclin E gene. 1. 8 123546 AA608817 Hs. 112597 EST 1. 8 124694 R06108 gb : ye94hO5. s1 Soaresfetalliverspleen 1. 8 102406 U43177 (NONE) 1. 8 130695 T97205 Hs. 17998 ESTs, Weakly similar to 2109260A B cell 1. 8 123951 A8012922 Hs. 173043 metastasis-associated 1-like 1 1. 8 118533 N71861 Hs. 49413 ESTs 1. 8 123197 AA489250 gb : aa57h12. s1 NCI_CGAP_GCB1 Homosapiens 1. 8 125656 AW516428 Hs. 78687 neutralsphingomyelinase (N-SMase) activ 1. 8 100154 H60720 Hs. 81892 KIAA0101 gene product 1. 8 106876 N52821 Hs. 269412 ESTs Moderately similar to ALU7 HUMAN A 1. 8 128339 AL121087 Hs. 296406 KIAA0685 gene product 1. 8 105939 AL137728 Hs. 12258 Homo sapiens mRNA ; cDNADKFZp434B0920 (f 1. 8 102495 NM_006762 Hs. 79356 Lysosomal-associated multispanning membr 1. 8

100221 D28383 gb : Human mRNA for ATP synthase B chain, 1. 8 101741 NM_003199 Hs. 326198 transcription factor 4 1. 8 101701 Nf002436Hs. 1861 membrane protein, palmitoylated 1 (55kD) 1. 8 107119 A1375499 Hs. 27379 ESTs 1. 8 134362 U47742 Hs. 82210 zinc finger protein 220 1. 8 127964 F06298 gb : HSC13F081 nommalizedinfantbraincDN 1. 8 101437 M20681 Hs. 7594 solute camer family 2 (facilitated glu 1. 8 106204 AA188734 Hs. 21479 ubinuclein 1 1. 8 112716 AW590680 Hs. 110802 von Willebrand factor 1. 8 109779 AB029396 Hs. 3353 beta-1, 3-giucuronyltransferase 1 (glucur 1. 8 111369 AA535740 Hs. 170263 tumor protein p53-binding protein, 1 1. 8 135204 AF067515 Hs. 183418 cell division cycle 2-like 1 (PITSLRE pr 1. 8 105788 AB009698 Hs. 23965 solute carder family 22 (organic anion 1. 8 110997 AW862823 Hs. 168052 KIAA0421 protein 1. 8 111620 R14853 Hs. 307478 EST, Weakly similar to 139058 hypothet 1. 8 115618 H11695 Hs. 322901 disnupterofsilencing 10 1. 8 115904 At167560 Hs. 61297 ESTs 1. 8 107510 BE613332 Hs. 132055 ESTs, Weakly similar to GNMSLL retroviru 1. 8 116435 AA186761 Hs. 334812 hypothetical protein DKFZp586K0717 1. 8 112399 R60920 Hs. 296770 KIAA1719 protein 1. 8 127426 AA854756 Hs. 124076 ESTs 1. 8 125175 W52355 Hs. 303030 EST 1. 8 132972 AA034365 Hs. 288924 Homo sapiens CDNA FLJ 11392 fis, clone HE 1. 8 125982 R98091 gb : yr30e11. r1Soaresfetalliverspleen 1. 8 115620 AA399997 Hs. 211610 CUG tripletrepeat, RNA-binding protein 1. 8 128115 A1435590 Hs. 130168 ESTs 1. 8 106880 A1493206 Hs. 32425 ESTs 1. 7 101199 L22075 Hs. 1666 guanine nucleoUde binding protein (G pr 1. 7 104159 BE386983 Hs. 283685 hypothetical protein FLJ20396 1. 7 101368 M13058 Hs. 73952 proline-rich protein Haelil subfamily 2 1. 7 103646 AW248439 Hs. 2340 junction plakoglobin 1. 7 130717 AA334274 Hs. 18368 DKFZP56480769 protein 1. 7 124981 N25485 Hs. 330310 maternal G10 ranscript 1. 7 124770 AA984414 Hs. 120429 ESTs 1. 7 126926 AA179472 Hs. 832 ESTs, HighlysimilartoA41029integrin 1. 7 101636 BE392781 Hs. 89474 ADP-ribosylationfactor6 1. 7 123553 Al494291 Hs. 111977 ESTs 1. 7 127172 AA292208 Hs. 251278 KIAA1201 protein 1. 7 130621 AW513087 Hs. 16803 LUC7 (S. cerevisiae)-like 1. 7 116925 H73110 Hs. 260603 ESTs, Moderately similar to A47582 B-ce 1. 7 108845 AW362901 Hs. 68864 ESTs, Weaklysimilartophosphatidylseri 1. 7 128092 AA904617 Hs. 166229 ESTs 1. 7 128193 AJ224442 Hs. 155020 putative methyltransferase 1. 7 113965 Al268666 Hs. 19631 ESTs, Weakly similar to 138022 hypothefi 1. 7 106620 D52562 Hs. 296317 KIAA1789 protein 1. 7 102926 W28363 Hs. 239752 nuclear receptor subfamily 2, group F, m 1. 7 114964 BE085271 Hs. 8834 nng finger protein 3 1. 7 101800 NM_006433 Hs. 105806 granulysin 1. 7 130094 NM_001471 Hs. 167017 gamma-aminobutyric acid (GABA) B recepto 1. 7 120112 AA180240 Hs. 6083 Homo sapiens cDNA : FLJ21028 fis, clone C 1. 7 109978 H09356 Hs. 22528 ESTs 1. 7 121252 AA393907 Hs. 97179 ESTs 1. 7 127768 AW085002 Hs. 156187 ESTs 1. 7 125445 A1452722 Hs. 7709 WW domain binding protein 1 1. 7 100052 1. 7 119863 AA081218 Hs. 58608 Homo sapiens cDNA FW14206 fis, ctone NT 1. 7 134333 AW888411 Hs. 81915 leukemia-associated phosphoprotein p18 (1. 7 123541 AW976511 Hs. 112592 ESTs 1. 7 134191 W26632 Hs. 7979 KIAA0736 gene product 1. 7 103305 X82279 gb : H. sapiens Fas, Apo-1 gene (promoter a 1. 7 112411 R43090 Hs. 271510 ESTs, Moderately similarto ALU1_HUMAN A 1. 7 100598 AL121734 Hs. 146409 celidivisioncycle42 (GTP-bindingprot 1. 7 113610 T93279 gb : ye25f01. s1 Stratagene lung (937210) H 1. 7 105593 AA279341 Hs. 174151 aldehyde oxidase 1 1. 7 125317 Z99348 Hs. 112461 ESTs, Weaklysimilartol38022hypotheE 1. 7 125956 AK000214 Hs. 129014 hypothetica protein FLJ20207 1. 7 105105 R61532 Hs. 87016 hypothetical protein FLJ22938 1. 7 132791 AB029551 Hs. 7910 R. NG1 and YY1 binding protein 1. 7 116996 H83935 Hs. 40535 ESTs 1. 7 133335 BE251012 Hs. 263812 nuclear distribution gene C (A. nidulans) 1. 7 120959 BE247692 Hs. 102469 putative nuclear protein 1. 7 105621 AL040058 Hs. 6375 uncharacterizedhypothatamus protein HTO 1. 7 106181 A1803651 Hs. 191608 ESTs 1. 7 125661 AA491830 Hs. 25689 ESTs 1. 7 127585 AA604144 Hs. 190632 ESTs 1. 7 112035 A1955289 Hs. 300759 ribosome protein L36 1. 7 102870 M64437 Hs. 234799 breakpoint cluster region 1. 7 108039 AA280319 Hs. 288840 PR01575 protein 1. 7 125898 AK001823 Hs. 92287 Homo sapiens mRNA ; cDNA DKFZp564C2478 (f 1. 7 114740 N70103 gb : za53e10. s1Soaresfetal liverspleen 1. 7 120304 AA192469 Hs. 271838 ESTs 1. 7 103433 X98001 Hs. 78948 Rab geranylgeranyltransferase, beta subu 1. 7 116180 AA463902 Hs. 13522 ESTs, Weakly similar to 138022 hypothet 1. 7

105269 AF174499 Hs. 6764 histone deacetylase 6 1. 7 125431 AW851639 Hs. 75584 polymyosiUs/scterodemma autoantigen 2 (1. 7 133579 X75346 Hs. 75074 mitogen-acuvated protein kinase-activat 1. 7 105355 AL031447 Hs. 26938 Homo sapiens, clone IMAGE : 4053044, mRNA, 1. 7 129601 AB032964 Hs. 115726 KIAA1138protein 1. 7 113739 AA356599 Hs. 173904 ESTs 1. 7 100840 U04816 Hs. 183418 cell division cycle 2-like 1 (PITSLRE pr 1. 7 122878 AA847744 Hs. 99640 ESTs 1. 7 119495 BE144608 Hs. 55533 ESTs 1. 7 125669 R51308 Hs. 333256 ESTs, WeaklysimitartoAW8_HUMANALU 1. 7 109891 H04757 Hs. 323176 ESTs 1. 7 126884 U49436 Hs. 286236 KIAA1856 protein 1. 7 132977 AA093322 Hs. 301404 RNA binding motif protein 3 1. 7 101396 BE267931 Hs. 78996 proliferating cell nuclear antigen 1. 7 104730 AW139789 Hs. 16370 Homo sapiens cDNAFLJ11652 fis, clone HE 1. 7 102205 BE242291 Hs. 197540 hypoxia-inducible factor 1, alpha subuni 1. 7 112945 AW138458 Hs. 20787 Homo sapiens cDNA : FLJ21686 fis, clone C 1. 7 129902 AA076278 Hs. 13277 hypothetical protein FLJ22054 1. 7 107157 AW853745 Hs. 286035 hypothetical protein FLJ22686 1. 7 133229 AL137480 Hs. 6834 KIAA1014 protein 1. 7 129912 AF155096 Hs. 107213 hypothetical protein FLJ20585 1. 7 119811 AW137640 Hs. 231444 Homo sapiens, Similar to hypothetical pr 1. 7 126323 N77584 Hs. 68644 Homo sapiens microsomal signai pep6dase 1. 7 133134 AF198620 Hs. 65648 RNAbindingmoffprotein8A 1. 7 115278 AK002163 Hs. 301724 hypothetical protein FLJ11301 1. 7 133817 AW578716 Hs. 7644 H1 histone tamily, member 2 1. 7 130753 AA205223 Hs. 189 phosphodiesterase 4C, cAMP-specific (dun 1. 7 107463 AW952022 Hs. 315164 hypothetical protein simfiartoactin re 1. 7 121009 Nom-001533 Hs. 2730 heterogeneous nuciear dbonucleoprotein 1. 7 125546 H09950 gb : ym01d12. rl Soares infant brain 1NIB H 1. 7 129991 R28386 Hs. 179925 ESTs, Weakly similar to ALUS HUMAN ALU 1. 7 119015 N95490 Hs. 29700 hypothetical protein FLJ20094 1. 7 100058 1. 7 116655 AF271732 Hs. 68090 bridging integrator-3 1. 7 119898 R93325 Hs. 58690 ESTs 1. 7 105021 H07960 Hs. 306044 CGi-05 protein 1. 7 102098 N25485 Hs. 330310 maternal G10 transcript 1. 7 126730 AA442429 gb : zv70g02. r1 Soan3s_totaJetus_Nb2HF8_ 1. 7 113427 T85105 Hs. 15471 ESTs 1. 7 122317 T85253 Hs. 290874 ESTs, Weakly similar to ALU8_HUMAN AW S 1. 7 130503 BE208491 Hs. 295112 KIAA0618 gene product 1. 7 117348 N24157 gb : yx96b12. s1 Soaresmelanocyte2NbHMHo 1. 7 127033 AF169301 Hs. 9098 sulfate transporter 1 1. 7 128554 AW972147 Hs. 101395 hypothetical protein MGC11352 1. 7 124733 R20547 Hs. 100830 ESTs 1. 7 106310 R98185 Hs. 17240 ESTs 1. 7 122638 AL137476 Hs. 123609 Homo sapiens mRNA ; cDNA DKFZp43410623 (f 1. 7 101075 L03532 Hs. 79024 heterogeneous nuclear ribonucleoprotein 1. 7 126659 T16245 gb : NIB1005R Normalized infant brain, Ben 1. 7 127717 F12209 Hs. 173380 CK2 interacting protein 1 ; HQ0024c prote 1. 7 105441 N28522 Hs. 8935 quinolinate phosphoribosyltransferase (n 1. 7 104188 AA478423 Hs. 300870 Homo sapiens mRNA ; cDNA DKFZp547M072 (fr 1. 7 134750 L29073 Hs. 1139 cold shock domain protein A 1. 7 106826 BE253927 Hs. 24983 hypothetical protein from EUROIMAGE 2021 1. 7 113511 T89578 Hs. 189740 ESTs 1. 7 111070 NM006201 Hs. 171834 PCTAIRE protein kinase 1 1. 7 129091 AA056483 Hs. 301463 Human Chromosome 16 BAC clone CIT987SK-A 1. 7 129710 AJ277841 Hs. 120963 ELG protein 1. 7 132833 U78525 Hs. 57783 eukaryotictransiation initiation factor 17 125775 AW514585 Hs. 29205 alpha integdn binding protein 63 1. 7 113675 T81034 Hs. 14841 ESTs 1. 7 100487 AU076640 Hs. 15243 nucleolar protein 1 (120kD) 1. 7 119302 T25725 gb : ESTDIR152CD34+DIRECTIONALHomosapie 1. 7 128245 AA993101 Hs. 170486 ESTs 1. 7 130322 NM_014247 Hs. 154545 PDZ domain containing guanine nucleotide 1. 7 135363 AW589601 Hs. 119 Wilms'tumour1-associatingprotein 1. 7 125181 R40815 Hs. 12396 ESTs, Weakly similar to 2004399A chromos 1. 7 132347 BE271016 Hs. 169850 ESTs, Weakly similar to T21554 hypotheti 1. 7 127206 AW816490 Hs. 337508 ESTs 1. 7 121880 AW946155 Hs. 7750 hypothetical protein AL133206 1. 7 125797 H03117 Hs. 111497 similar to mouse neuronal protein 15. 6 1. 7 114601 AA075566 gb : zm88fO6. s1 Stratagene ovarian cancer 1. 7 126278 AA417302 Hs. 63042 DKFZp564J157 protein 1. 7 120964 AA398085 Hs. 142390 ESTs 1. 7 133634 AL035071 Hs. 234279 microtubule-associated protein, RP/EB fa 1. 7 107025 AA825523 Hs. 21255 ESTs, Weakly similar to 138022 hypotheti 1. 7 105638 AA493453 Hs. 247817 H2B histonefamily, memberA 1. 7 135398 M16029 Hs. 287270 ret proto-oncogene (multiple endocrine 1. 7 115794 AA424900 Hs. 112227 membrane-associated nucleic acid binding 1. 7 102083 T35901 Hs. 75117 inter) enhancer binding factor 2, 4 1. 7 100188 AW247090 Hs. 57101 minichromosome maintenance deficient (S. 1. 7 130868 AB037855 Hs. 171917 hypothetical protein FLJ 11085 1. 7 110493 A1247707 Hs. 36915 ESTs 1. 7

115041 AA252457 Hs. 86543 ESTs, Moderately similar to T00256 hypot 1. 7 128764 AW024282 Hs. 104938 hypothetical protein MGC15906 1. 7 134065 X78992 Hs. 78909 butyrate response factor 2 (EGF-response 1. 7 101082 BE616731 Hs. 80645 interferon regulatory factor 1 1. 7 130945 U20582 Hs. 2149 acGn like protein 1. 7 106974 A1817130 Hs. 9195 Homo sapiens cDNA FW13698 fis, clone PL 1. 7 126752 Alto73373 Hs. 326923 EST, Weakly similar to 138022 hypothetic 1. 7 133327 AL390127 Hs. 7104 Kruppe)-) ikefactor13 1. 7 127005 T81309 Hs. 251664 insulin-like growth factor 2 (somatomedi 1. 7 105615 AA281959 Hs. 5210 glia maturation factor, gamma 1. 7 116295 AA742596 Hs. 91216 ESTs, Weakly similar to 2004399A chromos 1. 7 111587 Al125867 Hs. 20734 ESTs 1. 7 104570 AW978870 Hs. 131828 ESTs 1. 7 134752 BE246762 Hs. 89499 arachidonate 5-lipoxygenase 1. 7 130430 W27893 Hs. 150580 putative translation initiation factor 1. 7 119244 AW407564 Hs. 275865 ribosomal protein S18 1. 7 131152 NM 004380 Hs. 23598 CREB binding protein (Rubinstein-Taybi s 1. 7 133419 BE242676 Hs. 73172 growth factor independent 1 1. 7 106542 AA339541 Hs. 24956 hypothetical protein FLJ22056 1. 7 116482 AW207000 Hs. 126857 Homo sapiens cDNA FLJ12936 fis, clone NT 1. 7 132555 AW500131 Hs. 171763 CD22 antigen 1. 7 125840 AB028986 Hs. 12064 ubiquitin specific protease 22 1. 7 115416 AA283893 Hs. 337079 ESTs 1. 7 120041 AA830882 Hs. 59368 ESTs 1. 7 126295 A1281459 Hs. 270114 ESTs 1. 7 122528 AA449804 Hs. 292154 stroma cell protein 1. 7 Table 2B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 108451 1376627 AA079195AA084955AA126308AA084956 124236 46919 1 AF086006 H64722 H65212 H66282 115982 173_2 W92113 AA702794 BE044316 W91984 AA679375 T94184 AA679335 BE503126 AW502118 BE467367 AA584550 AW139964 R93353 AW088477 AI887846 AW502624 W81697 W81696 AA447817 AA447667 F13631 AW268271 AA055366 AW629027 AA677404 AA831618 AI124782 AA889402 AA765804 AA765530 AA055698 AA594019 AI267368 AAd56946 R93354 AF264624 AW668618 AA601493 116665 1394292_1 F04405 BE173130 125165 1852047 1 W45350W45406 125324 1692163 1 R07785 T85948 T86972 126053 1601238 1 H64450 H64464 125499 1562851_1 H10543R11878 126127 1205826 1 N95428 W24040 AW751366 H81987 125546 356478 1 H09950R18413M570553AW973425 125549 1702179 1 R20215R18767 125761 1744008_1 R68351 R68364 127155 2003581 AA284993AA478122AA477923 125957 1583542-1 H41694 H45213 125982 1766315 1 R98091 W92898 127245 2266621 AA323958AA370268 127248 227560 1 AA364195 AA325029 AW962050 127262 231725 1 AA828125 AA834883 AA330555 126659 1541209_1 T16245 R19694 F13545 H10299 T66048 T65279 H18006 127303 258778J AA366951AA470999AA469425 127315 37938 1 AF116622 AI i 14507 AA640834 AA377999 126730 297653 1 M442429T19477 103898 187213 3 AA248884 126872 142696 1 AW450979 AA136653 AA136656 AW419381 AA984358 AA492073 BE168945 AA809054 AW238038 BE011212 BE011359 BE011367 BE011368 BE011362 BE011215 BE011365 BE011363 112540 1605263 1 R69751 R70467 H69771 H80879 H80878 127705 966283 2 AJ003322AJ003324 121335 279548 1 AA404418 A1217248 120734 208882 1 AA299948 AA299949 114620 320628 AA642974 AA084223 122652 2640130 AA454641 123636 genbank AA609263 AA609263 100842 tigrHT4398 U05597 116548 genbank_D20433 D20433 123783 genbanLAA610112 AA610112 125032 genbankT74884 T74884 123808 genbankAA620552 AA620552 102316 entrez_U34301 U34301 102406 entrezU43177 U43177 134076 40321 1 AF086215 W02702 AA284288 W25655 104542 R29657 113119 genbank_T47910 T47910 104799 genbankAA029703 AA029703 127964 135151 1 F06298 R18057 120809 genbankAA346495 AA346495 113610 genbank_T93279 T93279 113947 genbankW84768 101045 entrez J05614

129969 genbank N57818 117031 genbank_H88353 101447 entrez M21305 124540 genbank_N63232 124554 genbank_N65961 117348 genbankLN24157 117357 genbank_N24829 124677 genbank_R01073 124694 genbankR06108 103138 entrez_X65965 103305 entrez_X82279 103392 entrez_X94563 103403 entrez_X95406 119229 genbank_T03229 119302 genbank_T25725 126825 4304581 AA100230AA100274 105225 genbank_AA211777 121292 genbankAA401807 112853 genbankT02843 T02843 121387 genbank_M405854 114601 genbankAA075566 100221 entrez_D28383 D28383 123197 genbankAA489250 AA489250 114740 379876 1 N70103 N70020 AW383189 Al207469W00935 W00906M551569A1343637 M135199 123331 genbank_M497013 107794 genbanLAA019255 100554 6gr_HT2241 M95923 123423 genbank_AA598484 123474 genbank_M599209 109061 genbank_M160896 TABLE 3A : About 1346 Genes Up-regulated in Acute Lymphocytic Leukemia (ALL) Compared to Normal Adult Hematopoie6c Tissues Table 3A lists about 1346 genes up-regulated in acute ymphocytic leukemia (ALL) compared to normal adult hematopoietic tissues. These were selected from 35403 probesets on the Affymetrix/Eos Hu01 GeneChip array such that the ratio of'average'teukemia to'average'normal adutt hematopoietic tissues was greater than or equal to 3. 0. The'average' leukemia level was set to the 85" percentile amongst various ALL samples. The'average'normal adult hematopoie6c Essue teve. was set to the 75' percentile amongst various non- malignant hematopoietic tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10''percenUle value amongst the tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of leukemia to hematopoietic tissues Pkey ExAccn UnigenelD UnigeneTitle R1 129498 AA449789 Hs. 75511 connective tissue growth factor 57. 88 100458 S74019 Hs. 247979 pre-Blymphocytegene1 49, 45 133774 X54079 Hs. 76067 heat shock 27kD protein 1 48. 42 102564 U59423 Hs. 79067 MAD (mothers against decapentaplegic, Dr 41. 49 130650 AB040951 Hs. 284208 DKFZP434N161 protein 35. 88 132922 AF249745 Hs. 6066 Rho guanine nucleo6de exchange factor 35. 74 112254 AA852097 Hs. 25829 ras-related protein 33. 28 106706 AB037810 Hs. 18760 KIAA1389 protein 32. 39 101050 AU077324 Hs. 1832 neuropeptide Y 30. 68 102455 U48705 Hs. 75562 discoidindomainreceptorfamity. member 26. 81 101838 BE243845 Hs. 75511 connective tissue growth factor 25. 46 113374 T79925 Hs. 269165 ESTs, Weakly similar to ALU1 HUMAN ALU S 24. 69 134125 NM_014781 Hs. 50421 KIAA0203 gene product 24. 63 106943 AW888222 Hs. 9973 tensin 23. 14 130069 A1754813 Hs. 146428 collagen, typeV, alpha 1 23. 06 119073 BE245360 Hs. 279477 ESTs 22. 53 130444 M12125 Hs. 300772 tropomyosin2 (beta) 21. 96 100420 D86983 Hs. 118893 Melanoma associated gene 21. 05 114324 AF084481 Hs. 26077 Wolframsyndrome1 (wolframin) 18. 95 101400 M15990 Hs. 194148 v-yes-1 Yamaguchi sarcoma viral oncogene 18. 46 102759 NM005100 Hs. 788 A kise (PRKA) anchor protein (gravin) 17. 88 100893 BE245294 Hs. 180789 S164 protein 16. 75 131689 AB012124 Hs. 30696 transcription factor-like 5 (basic helix 16. 60 106410 AB037787 Hs. 26229 neuroligin 2 16. 51 101304 AA001021 Hs. 6685 thyroid hormone receptor interactor 8 15. 60 131524 AB040927 Hs. 301804 KIAA1494 protein 15. 01 107794 AA019255 gb : ze56e10. s1 Scares retiN2b4HR Homo 14. 78 129213 Ait46494 Hs. 109525 ESTs, Weakly similar to IRX2 HUMAN IROQU 14. 76 116068 AA328041 Hs. 194329 hypothetical protein FLJ21174 14. 24 134416 X68264 Hs. 211579 melanoma cell adhesion molecule 14. 06 134545 Al902899 Hs. 85155 butyrate response factor 1 (EGF-response 14. 03 114009 A1248544 Hs. 103000 KIAA0831 protein 13. 93 115110 AK001671 Hs. 11387 KIAA1453 protein 13. 75 130107 AF112977 Hs. 172887 phytanoyl-CoA hydroxylase (Refsum diseas 13. 60 133558 X66945 Hs. 748 fibroblast growth factor receptor 1 (fms 13. 60 100871 T85231 Hs. 179661 tubulin, beta 5 13. 50 101462 AL035668 Hs. 73853 bone morphogenetic protein 2 13. 48 120809 AA346495 gb : EST52657 Fetal heart 11 Homo sapiens 13. 33

123340 AA504264 Hs. 182937 peptidyiprotylisomeraseA (cyclophitin 13. 25 103460 A1021993 Hs. 14331 S100 calcium-binding protein A13 13. 25 102460 U48959 Hs. 211582 myosin. lightpolypeptide kise 13. 14 100168 H73444 Hs. 394 adrenomedullin 13. 09 115844 Api373062 Hs. 332938 hypothetical protein MGC5370 13. 00 130103 Y13492 Hs. 149098 smoothelin 12. 92 102407 AW602154 Hs. 82143 E74-likefactor2 (ets domain transcript 12. 03 113632 T94907 Hs. 188572 ESTs 11. 85 118951 NM_000448 Hs. 73956 Kcombitionactivatnggenel 11. 73 100305 NM004941 Hs. 171872 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 11. 63 109737 AA055415 Hs. 13233 ESTs, Moderately similar to A47582 B-cel 11. 55 122577 AA829725 Hs. 334437 hypothe6caiproteinMGC4248 11. 49 115147 AA745781 Hs. 38399 hypothetical protein MGC2454 11. 40 132303 BE177330 Hs. 325093 Homo sapiens cD. FLJ21210 fis, clone C 11. 37 103176 AL021154 Hs. 76884 inhibitorofDbinding3, domintneg 11. 17 108358 M81933 Hs. 1634 cell division cycle 25A 11. 15 104584 AA704538 Hs. 193777 ESTs 11. 12 106777 AF037261 Hs. 33787 vinexin beta (SH3-containing adaptor mol 11. 08 121054 AW976570 Hs. 97387 ESTs 10. 90 119400 T92767 gb : ye27dO6. s1 Stratagene lung (937210) H 10. 83 126610 Al911353 Hs. 191391 ESTs 10. 83 134555 U34879 Hs. 85279 hydroxysteroid (17-beta) dehydrogese 1 10. 80 131555 T47364 Hs. 278613 interferon. alpha-inducible protein 27 10. 79 130979 NM012446 Hs. 169833 single-stranded-D-binding protein 10. 70 113783 AL359588 Hs. 7041 hypothetical protein DKFZp762B226 10. 65 123503 AW975051 Hs. 293156 ESTs, Weakly similar to 178885 sedne/th 10. 60 117031 H88353 gb : yw21a02. s1 Morton Fetà Cochlea Homo 10. 45 100752 T81309 Hs. 251664 insulin-like growth factor 2 (somatomedi 10. 44 102618 AL037672 Hs. 81071 extraceliular matix protein 1 10. 36 113089 T40707 Hs. 270862 ESTs 10. 33 132089 W22007 Hs. 39122 hypothetical protein MGC15737 10. 29 101663 NM_003528 Hs. 2178 H2B histone family, member Q 10. 23 104876 A1933128 Hs. 25220 like-glycosyltransferase 10. 23 106370 AF039843 Hs. 18676 sprouty (Drosophila) homolog 2 10. 18 129406 AB018255 Hs. 111138 KlM0712geneproduct 10. 18 115354 AA281636 Hs. 334827 ESTs 10. 13 123077 AA485229 Hs. 105649 ESTs 10. 05 131273 AW206008 Hs. 283378 Homo sapiens cD : FLJ21778 fis, clone H 9. 95 126177 AW752782 Hs. 129750 hypothetical protein FLJ10546 9. 83 133699 BE501689 Hs. 75617 collagen, type IV, alpha 2 9. 80 110855 AB007928 Hs. 28169 KIAA0459 protein 9. 65 111826 R35975 gb : yh91b07. s1 Soares placenta Nb2HP Homo 9. 58 126947 Z40778 Hs. 191837 ESTs 9. 50 116674 A1768015 Hs. 92127 ESTs 9. 48 129087 A1348027 Hs. 108557 hypothetical protein PP1057 9. 46 114837 BE244930 Hs. 166895 ESTs 9. 45 120009 A1080491 Hs. 93270 ESTs, Moderately similar to S65657 alpha 9. 45 112483 AW969785 Hs. 285885 Homo sapiens cD FLJ11321 fis, clone PL 9. 40 103487 AA743603 Hs. 172108 nucleoporin 88kD 9. 30 105675 AL390083 Hs. 271277 hypothetical protein from EUROIMAGE 3636 9. 28 129158 NM 004413 Hs. 109 dipepEdase1 (rel) 9. 23 114394 T34462 Hs. 103291 neuritin 9. 17 133331 Y14487 Hs. 738 ribosomal protein L14 9. 11 114787 AA156509 Hs. 231892 ESTs, Weakly similar to S65657 alpha-1 C-9. 10 125502 AW977181 Hs. 194718 zinc finger protein 265 9. 03 132325 N37065 Hs. 44856 hypothetical protein FU12116 9. 01 127968 AA830201 Hs. 124347 ESTs 9. 00 114605 AL157423 Hs. 306478 Homo sapiens mR ; cD DKFZp76100511 (f 8. 93 114875 AA235609 Hs. 236443 Homo sapiens mR ; cD DKFZp564N1063 (f 8. 93 129898 Art672731 Hs. 13256 ESTs 8. 89 106263 W21493 Hs. 28329 hypothetical protein FLJ14005 8. 89 117130 AA748850 Hs. 125830 bladdercanceroverexpressedprotein 8. 88 105553 AA256756 Hs. 31178 ESTs 8. 85 103657 Z73677 gb : H. sapiens gene encoding plakophilin 1 8. 83 105831 AA329449 Hs. 247302 twisted gastrulation 8. 82 106375 AW872878 Hs. 289072 hypothetical protein FU22175 8. 80 114518 AW163267 Hs. 106469 suppressor of var1 (S. cerevisiae) 3-like 8. 75 123433 AW450922 Hs. 112478 ESTs 8. 67 134558 NM_001773 Hs. 85289 CD34 antigen 8. 67 115893 Al652127 Hs. 48419 ESTs 8. 67 128621 AA032197 Hs. 102558 Homo sapiens, clone MGC : 5352, mR, comp 8. 60 122798 AW366286 Hs. 145696 splicing factor (CC1. 3) 8. 58 112554 R71489 Hs. 29196 EST 8. 55 129969 N57818 gb : yv59dO7. s1 Soaresfetalliverspleen 8. 53 131558 AA453208 Hs. 28726 RAB9, member RAS oncogene family 8. 45 134027 Z97630 Hs. 226117 HI histone family, member 0 8. 45 134138 AB023169 Hs. 7935 KIAA0952 protein 8. 43 120030 A1076355 Hs. 58694 ESTs 8. 43 101005 NM_005239 Hs. 85146 v-ets avian erythroblastosis virus E26 o 8. 33 115423 A1499516 Hs. 89303 ESTs 8. 33 104946 AW242407 Hs. 73848 carcinoembryonic an6gen-related cell ad 8. 30 131965 W79283 Hs. 35962 ESTs 8. 30 126426 AA125984 gb : zn27h06. rl Stratagene neuroepithelium 8. 28

108886 AW248434 Hs. 91521 hypothetical protein 8. 26 107985 T40064 Hs. 71968 Homo sapiens mR ; cDDKFZp564F053 (fr 8. 25 114239 AL137667 Hs. 267445 Homo sapiens mR ; cD DKFZp434B231 (fr 8. 23 124281 AI333756 Hs. 111801 arseteresistanceproteinARS2 8. 23 117099 H93699 gb : yv16a11. s1 Soaresfetalliverspleen 8. 20 119432 AL120247 Hs. 40109 KIAA0872 protein 8. 15 115967 A1745379 Hs. 42911 ESTs 8. 15 132355 D87942 Hs. 46328 fucosyltransferase 2 (secretor status in 8. 13 108339 AW151340 Hs. 51615 ESTs, WeakìysimilartoALU7 HUMANAW S 8. 10 131694 NM 000246 Hs. 3076 MHCclass II transac6vator 8. 05 104897 N33937 Hs. 10336 ESTs 8. 03 120266 A1807264 Hs. 205442 ESTs, Weakly similar to T34036 hypotheu 8. 03 130404 A1672727 Hs. 76753 endoglin (Oster-Rendu-Weber syndrome 1) 8. 00 115729 AA417812 Hs. 38775 ESTs 8. 00 127216 A1798703 Hs. 143702 ESTs, Weakly similar to S70029 probable 7. 95 131693 AW963776 Hs. 110796 SARI protein 7. 93 113107 A1821027 Hs. 8429 ESTs 7. 90 122282 BE246331 Hs. 98401 HomosapiensmRfulitengthinsertcDN 7. 90 111040 A1435502 Hs. 14931 ESTs 7. 90 127987 A1022103 Hs. 124511 ESTs 7. 90 125317 Z99348 Hs. 112461 ESTs, Weaklysimilarbì38022hypotheS 7. 88 105242 Api564857 Hs. 27888 ESTs, Weaklysimilartoserinelthreonine 7. 75 100421 D86985 Hs. 79276 KfAA0232 gene product 7. 71 114359 NM_016929 Hs. 283021 chlorideintracellularchannel5 7. 70 119772 AJ250839 Hs. 58241 geneforserine/threonineproteinkise 7. 70 124040 U23752 Hs. 32964 SRY (sex determining regions-box 11 7. 65 134361 BE549343 Hs. 82208 acyi-CoenzymeAdehydnogese, verylong 7. 57 105476 AL117352 Hs. 120828 HumanDsequencefromcloneRP5-876B10 7. 55 113289 T66900 Hs. 188446 ESTs 7. 50 122707 NM002039 Hs. 239706 GRB2-associated binding protein 1 7. 50 130055 A1566248 Hs. 146355 v-abl Abelson murine leukemia vira onco 7. 49 108766 AF145713 Hs. 61490 schwannomin-interacting protein 1 7. 45 107957 Z36842 Hs. 57548 ESTs 7. 45 123116 AW190412 Hs. 183738 FERM, RhoGEF (ARHGEF) and pleckstrin dom 7. 38 123190 AA489212 Hs. 105228 EST 7. 38 129574 AA026815 Hs. 11463 UMP-CMPkise 7. 38 115274 C01566 Hs. 86671 ESTs 7. 35 102571 U60115 Hs. 239069 four and a half UM domains 1 7. 34 116845 AA649530 gb : ns44f05. s1 NCt_CGAP_Alv1 Homosapiens 7. 33 134851 AB011124 Hs. 90232 KIAA0552 gene product 7. 33 101780 M82882 Hs. 154365 E74-likefactor1 (etsdomaintranscript 7. 28 125042 T78906 Hs. 269432 ESTs, Moderately similar to ALE1 HUMAIN A 7. 28 118472 AL157545 Hs. 42179 bromodomain and PHD finger containing, 3 7. 25 108700 AA121518 Hs. 193540 ESTs, Moderately similar to 2109260ABc 7. 23 109411 R98881 Hs. 109655 sex comb on midleg (Drosophila)-like 1 7. 20 127692 A1021912 Hs. 187983 ESTs 7. 18 128501 AL133572 Hs. 199009 protein containing CXXC domain 2 7. 18 107727 AA149707 Hs. 173091 ubiquitin-like 3 7. 14 118089 A1762507 Hs. 47878 ESTs 7. 12 106025 AV653785 Hs. 173334 ELL-RELATED R POLYMERASE ìl, ELONGATIO 7. 10 122111 AW593206 Hs. 98785 Ksp37 protein 7. 08 119674 W60379 Hs. 57773 ESTs 7. 05 126607 W87425 Hs. 114688 ESTs 7. 05 121545 AA412442 Hs. 98132 ESTs 7. 05 113287 T66847 Hs. 194040 ESTs, Weakly similar to 138022 hypotheti 7. 03 126672 AA255592 Hs. 203631 ESTs, Weakly similar to dterfively sp 7. 00 132087 H14486 Hs. 3903 Cdc42 effector protein 4 ; binder of Rho 6. 97 118697 N22706 Hs. 43234 ESTs 6. 97 100295 M74782 Hs. 172689 interleukin 3 receptor, alpha (low affin 6. 95 101188 L20320 Hs. 184298 cyclin-dependent kise 7 (homolog of Xe 6. 95 121481 AA411931 gb : zu03g05. s1 Soares_testis_NHT Homo sap 6. 95 113003 AW292315 Hs. 7215 ESTs 6. 93 101851 BE260964 Hs. 82045 midkine (neurite growth-promo6ng factor 6. 91 113529 A1190741 Hs. 177415 Finkel-Biskis-Reillymorinesarcomaviru 6. 90 132887 AA195831 Hs. 273385 guanine nucleotide binding protein (G pr 6. 90 113560 T91015 Hs. 268626 ESTs 6. 85 123440 A1733692 Hs. 112488 ESTs 6. 83 130390 AA490770 Hs. 182382 ESTs 6. 83 133889 U48959 Hs. 211582 myosin, light polypeptide kise 6. 83 113573 R89379 Hs. 15990 ESTs 6. 80 112453 R63899 Hs. 28455 ESTs 6. 78 125221 AA236115 Hs. 120785 ESTs 6. 78 134081 AL034349 Hs. 79005 protein tyrosine phosphatase, receptor t 6. 77 127610 AA960867 Hs. 150271 ESTs, Highly similar to unmed protein 6. 75 105486 AW449258 Hs. 6187 ESTs 6. 75 107796 AA058848 Hs. 60797 ESTs 6. 71 132754 A1752244 Hs. 75309 eukaryotic translation elongation factor 6. 71 105806 AF206019 Hs. 110347 REV1 (yeasthomotog)-tike 6. 70 110837 H03109 Hs. 108920 HT018 protein 6. 65 117698 N62293 Hs. 45107 ESTs 6. 65 128994 AF205849 Hs. 107740 Kruppel-tike factor 2 (lung) 6. 65 129131 AB026436 Hs. 177534 dual specificity phosphatase 10 6. 65 108528 AA650558 Hs. 325202 ESTs, Highly similar to GBAS_HUMAN GUANt 6. 62

131009 AF169802 Hs. 22142 cytochrome b5 reductase b5R. 2 6. 61 129389 NM 012445 Hs. 288126 spondin 2, extracellular matrix protein 6. 60 125278 A1218439 Hs. 129998 enhancer of polycomb 1 6. 59 124667 W24320 Hs. 102941 Homo sapiens cD : FLJ21531 fis, clone C 6. 59 105640 AA001021 Hs. 6685 thyroid hormone receptor interactor 8 6. 58 106474 BE383668 Hs. 42484 hypothetical protein FLJ10618 6. 58 105808 AI133161 Hs. 286131 CGt-101 protein 6. 53 120087 AF186780 Hs. 79219 RaIGDS-like gene ; KIAA0959 protein 6. 52 100514 AU076887 Hs. 28491 spermidinelspermine N1-acetyltransferase 6. 50 108378 A1368460 Hs. 74615 platelet-dedved growth factor receptor, 6. 50 133350 Api499220 Hs. 71573 hypothetical protein FLJ10074 6. 50 115673 AA406341 Hs. 269908 HomosapienscDFW11991fis, cloneHE 6. 48 133410 Y07847 Hs. 73088 RAS-related on chromsome 22 6. 48 131281 AA251716 Hs. 25227 ESTs 6. 46 105510 Z42047 Hs. 283978 Homo sapiens PR02751 mR, complete cds 6. 45 128766 AW160432 Hs. 296460 craniofacia development protein 1 6. 45 114530 AA601038 Hs. 191797 ESTs, Weakly similar to S65657 alpha-1 C-6. 43 120120 BE547267 Hs. 59791 hypothetical protein MGC13183 6. 40 120593 AA748355 Hs. 193522 ESTs 6. 40 125832 AA628600 Hs. 117587 ESTs 6. 38 129637 NM 004606 Hs. 1179 TATA box binding protein (TBP)-associate 6. 38 115302 AL109719 Hs. 47578 ESTs 6. 33 126137 AA312594 Hs. 99115 hypothetical protein FU20689 6. 30 114465 BE621056 Hs. 131731 hypothetical protein FLJ11099 6. 29 125562 A1494372 Hs. 98968 hypothetical protein FLJ23058 6. 29 127380 AF070554 Hs. 15535 Homo sapiens clone 24582 mR sequence 6. 26 106956 R06428 Hs. 226351 ESTs 6. 25 105962 AW880358 Hs. 339808 hypothetical protein FLJ10120 6. 25 109416 BE268388 Hs. 86945 ESTs, Weakly similar to A46010 X-linked 6. 23 111116 AK002039 Hs. 26243 Homo sapiens cD FLJ11177 fis, clone PL 6. 23 127282 AA347158 Hs. 185780 ESTs 6. 23 113074 AK001335 Hs. 31137 protein tyrosine phosphatase, receptor t 6. 21 101664 AA436989 Hs. 121017 H2Ahistonefamily, memberA 6. 20 103317 X83441 Hs. 166091 ligase IV, D, ATP-dependent 6. 20 133894 AW021236 Hs. 180433 rTS beta protein 6. 19 109260 AW978515 Hs. 131915 KIAA0863 protein 6. 18 112772 A1992283 Hs. 35437 ESTs, Moderately similar to 138026 MLN 6 6. 18 132050 A1267615 Hs. 38022 ESTs 6. 18 113009 T23699 Hs. 7246 ESTs 6. 17 118835 AA535246 Hs. 50852 ESTs 6. 16 125626 A1038854 Hs. 180789 S164 protein 6. 15 117086 AA581602 Hs. 41840 ESTs 6. 14 101960 AL036287 Hs. 194662 calponin 3, acidic 6. 13 104488 N56191 Hs. 106511 protocadherin 17 6. 13 127695 AA714731 Hs. 291457 ESTs, Weakly similar to heterogeneous d 6. 13 127894 AL121053 Hs. 5534 Homo sapiens cD FLJ12961 fis, clone NT 6. 13 113595 T92056 Hs. 290240 ESTs, ModeratelysimilartoALU2_HUMANA 6. 10 120784 AW752101 Hs. 16580 hypothetical protein FLJ11026 6. 10 115004 AA329340 Hs. 4867 mannosyl (alpha-1, 3-)-glycoprotein beta-6. 08 129740 BE165866 Hs. 83623 nuclear receptor subfamily 1, group I, m 6. 05 117483 N72185 Hs. 44189 ESTs 6. 04 103815 BE245294 Hs. 180789 S164 protein 6. 03 122040 AA847758 Hs. 111030 ESTs 6. 03 109638 AW977747 Hs. 119120 E3ubiquian. igaseSMURF1 6. 02 112727 T91029 Hs. 15069 ESTs 6. 01 120273 AA176688 Hs. 269284 ESTs 6. 00 122127 AW207175 Hs. 106771 ESTs 6. 00 126046 AA804957 Hs. 119840 ESTs 5. 99 119774 AB032977 Hs. 6298 KIAA1151 protein 5. 98 106265 AA412176 Hs. 236463 Homo sapiens mR ; cDDKFZp58610521 (f 5. 98 111987 NM015310 Hs. 6763 KIAA0942 protein 5. 98 123619 AA602964 gb : no97c02. s1 NCI_CGAP_Pr2 Homo sapiens 5. 96 128122 A1267491 Hs. 160593 ESTs 5. 95 128473 T78277 Hs. 100293 0-linked N-acetylglucosamine (Gicc) tr 5. 95 102283 AW161552 Hs. 83381 guanine nucleotide binding protein 11 5. 94 122468 AA448172 Hs. 137687 ESTs, HighlysimilartoK6B1_HUMANR. BOS 5. 93 101801 M86407 Hs. 1216 actinin, alpha 3 5. 93 107059 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homo) (E coli Re 5. 92 108908 AA136569 Hs. 10848 KIAA0187 gene product 5. 90 121470 AA558958 Hs. 324751 ESTs 5. 90 131938 AF176085 Hs. 34956 neural polypyrimidine tract binding prot 5. 89 109613 H47315 Hs. 27519 ESTs 5. 89 109384 AA219172 Hs. 86849 ESTs 5. 88 118559 N68456 Hs. 49519 ESTs 5. 88 102010 U02687 Hs. 385 fms-related tyrosine kise 3 5. 86 105921 AA421973 Hs. 169119 ESTs, Weakly similar to T25731 hypotheti 5. 85 124298 H91679 gb : yv04a07. s1 Scares fetal liver spleen 5. 85 120827 AA382525 Hs. 132967 Human EST clone 122887 mariner transposo 5. 84 103331 Api825463 Hs. 147996 protein kise, X-linked 5. 82 135052 AL136653 Hs. 93675 decidual protein induced by progesterone 5. 80 115219 AA262776 Hs. 269314 Homo sapiens cD FLJ14123 fis, done MA 5. 78 121899 R55341 Hs. 50421 KIAA0203 gene product 5. 78 135217 AA453880 Hs. 9658 hypothetical protein FLJ11790 5. 77

123973 C14805 gb : C14805 Clontech human aorta po. yA+ mR 5. 77 112605 R79374 Hs. 29852 ESTs 5. 76 110151 H18835 Hs. 31608 hypothetical protein FLJ20041 5. 75 129889 AA810932 Hs. 131899 ESTs, WeaklysimilartoT00370hypothe6 5. 75 102638 U67319 Hs. 9216 caspase 7, apoptosis-related cysteine pr 5. 73 121501 AA470687 Hs. 104772 ESTs 5. 73 124921 R93082 Hs. 332635 ESTs 5. 70 109850 Api150548 Hs. 23155 ESTs 5. 70 120594 AW136478 Hs. 5094 ring finger protein 10 5. 70 126433 AA325606 gb : EST28707 Cerebellum 11 Homo sapiens c 5. 70 100455 AW888941 Hs. 75789 N-myc downstream regulated 5. 69 106565 NM_014892 Hs. 227602 KIAA1116 protein 5. 68 120912 AA376690 Hs. 187650 ESTs 5. 68 127209 AA305023 Hs. 81964 SEC24 (S. cerevisiae) related gene famil 5. 68 107606 AF207989 Hs. 330425 Homo sapiens. Similar to G protein-coup) 5. 67 106597 Al091277 Hs. 302634 frizzled (Drosophila) homolog 8 5. 66 102126 AW950870 Hs. 78961 protein phosphatase 1, regulatory (inhib 5. 65 100064 AFFXcontrol-TrpnX-3 5. 63 108758 AA127395 Hs. 222414 ESTs 5. 63 101392 NM 002507 Hs. 1827 nerve growth factor receptor (TNFR super 5. 61 102211 BE314524 Hs. 78776 putative transmembrane protein 5. 60 107427 W26975 Hs. 46736 hypothetical protein FU23476 5. 60 135175 M91463 Hs. 95958 solute carrier family 2 (facilitated glu 5. 60 111764 A1420368 Hs. 290259 ESTs, Weaklysimitartoi38022hypothet 5. 58 119405 T93865 Hs. 91085 ESTs 5. 58 126464 A1990046 Hs. 54780 transcripUon tertnition factor, R po 5. 58 133865 AB011155 Hs. 170290 discs, iarge (Drosophila) homolog 5 5. 58 123255 AA830335 Hs. 105273 ESTs 5. 57 122861 AA335721 Hs. 119394 ESTs 5. 56 112046 AA383343 Hs. 22116 CDC14 (cell division cycle 14, S. cerevi 5. 55 132906 BE613337 Hs. 234896 geminin 5. 55 109001 A1056548 Hs. 72116 hypothetical protein FLJ20992 similar to 5. 55 115816 BE042915 Hs. 287588 Homo sapiens cD FLJ13675 fis, clone PL 5. 55 128401 R01865 Hs. 268586 ESTs 5. 53 129296 A1051967 Hs. 110122 ESTs 5. 53 120314 T10013 Hs. 221040 HBS1 (S. cerevisiae)-like 5. 51 132815 A1815189 Hs. 57475 sex comb on midleg homolog 1 5. 50 113983 W87415 Hs. 55296 HLA-B associated transcript-1 5. 50 105002 M224244 Hs. 182704 ESTs, Moderately similar to altertivel 5. 49 132025 AA011117 Hs. 3745 milk fat globule-EGF factor 8 protein 5. 49 110732 AW070838 Hs. 174174 KIAA0601 protein 5. 48 112891 T03927 Hs. 293147 ESTs, Moderately similar to A46010 X-lin 5. 48 126758 A1559444 Hs. 293960 ESTs 5. 48 129426 AF077953 Hs. 111323 Protein inhibitor of activated STAT X 5. 47 103217 NM001841 Hs. 73037 canbinoid receptor 2 (macrophage) 5. 46 132261 U80743 Hs. 306094 trinucleo6derepeatcontaining12 5. 45 105586 AA865118 Hs. 191538 ESTs 5. 43 109454 AA232255 Hs. 295232 ESTs, Moderately similar to A46010 X-lin 5. 43 113063 W15573 Hs. 5027 ESTs, Weakly similar to A47582 B-cell gr 5. 43 134092 AA218558 Hs. 7905 sorting nexin 9 5. 41 119316 A1114630 Hs. 208334 HomosapienscD : FLJ21874 fis, clone H 5. 38 108019 A1017773 Hs. 249159 adrenergic, alpha-2A-, receptor 5. 38 109421 AW604652 Hs. 332442 ESTs 5. 38 111929 AF027208 Hs. 112360 prominin (mouse)-like 1 5. 38 119718 W69216 Hs. 92848 ESTs 5. 38 106154 BE540255 Hs. 6994 Homo sapiens cD : FLJ22044 fis, clone H 5. 35 108544 W39433 Hs. 23971 hypothetical protein DKFZp547N043 5. 35 119580 AL079310 Hs. 92260 high-mobility group protein 2-like 1 5. 35 126777 AL157491 Hs. 145211 HomosapiensmR ; cDDKFZp434K1111 (f 5. 35 112944 H18063 Hs. 13254 ESTs 5. 34 103149 NM006201 Hs. 171834 PCTAIRE protein kise 1 5. 34 132437 AA152106 Hs. 4859 cyclin L ania-6a 5. 33 103860 AW976877 Hs. 38057 ESTs 5. 33 104865 T79340 Hs. 22575 8-cett CLLNymphoma 6, member B (zinc fi 5. 33 129914 NM 012421 Hs. 13321 rearranged L-mycfusion sequence 5. 33 130309 AF067804 Hs. 15423 hypothetical protein HDCMC04P 5. 31 116312 BE379794 Hs. 65403 hypothetical protein 5. 30 124191 T96509 Hs. 248549 ESTs, Moderately similar to S65657 alpha 5. 28 125583 AA195667 Hs. 86022 ESTs 5. 28 130591 N59646 Hs. 169745 crumbs (Drosophila) homolog 1 5. 28 116355 AA789133 Hs. 88650 ESTs 5. 26 115553 AJ275986 Hs. 71414 transcription factor (SMIF gene) 5. 26 122802 A1687303 Hs. 285529 G protein-coupled receptor 49 5. 25 128495 NM005904 Hs. 100602 MAD (mothers against decapentaplegic, Dr 5. 24 117667 U59305 Hs. 44708 Ser-Thr protein kise related to the my 5. 23 127890 AA294934 Hs. 293902 ESTs, Weakly similar to ISHUSS protein d 5. 22 134843 AA428520 Hs. 90061 progesterone binding protein 5. 21 120968 AA528283 Hs. 292737 ESTs 5. 21 102076 BE299197 Hs. 179665 cyclin-dependent kise inhibitor1A (p2 5. 20 100934 J03019 Hs. 99913 adrenergic, beta-1-, receptor 5. 20 112667 BE538516 Hs. 15423 hypothetical protein HDCMC04P 5. 20 119304 AW249266 Hs. 98493 X-ray repair complementing defective rep 5. 20 131868 AW408296 Hs. 33532 zinc finger protein 151 (pHZ-67) 5. 20

105914 AW245680 Hs. 9701 growth arrest and D-damaXqe-inducib. e, 5. 18 102258 NM001546 Hs. 34853 inhibitor of D binding 4, domint neg 5. 18 103850 AA187101 Hs. 213194 hypothetical protein MGC10895 5. 18 112516 T83909 gb : yd67f10. r1Soares fetal liver spleen 5. 18 133640 AW246428 Hs. 75355 ubiquian-conjugaUng enzyme E2N (homo) o 5. 18 135180 D90070 Hs. 96 phorbol-12-myristate-13-acetate-induced 5. 18 135309 Api564123 Hs. 42500 ADP-ribosylation factor-like 5 5. 18 134801 S76825 Hs. 89695 insulin receptor 5. 17 133362 AK001519 Hs. 7194 CGI-74 protein 5. 17 135206 AB024703 Hs. 96334 ring finger protein 11 5. 15 111480 R06453 Hs. 19706 ESTs 5. 15 118466 N66741 gb : yz33g08. s1 Morton Fetal Cochlea Homo 5. 15 125757 AI274906 Hs. 166835 ESTs, Highlysimilarto1814460Ap53-ass 5. 15 127140 At273507 Hs. 303966 ESTs 5. 15 109223 AW000714 Hs. 65818 ESTs 5. 14 103656 Z73497 Hs. 247802 Human D sequence from clone U240C2 on 5. 14 133388 AW245631 Hs. 182447 heterogeneous nuclear ribonucleoprotein 5. 12 100511 M76676 Hs. 116840 ESTs 5. 10 101941 S77583 gb : HERVK10/HUMMTV reverse transcriptase 5. 10 109937 Ai084066 Hs. 20072 myosin regulatory light chain interacUn 5. 10 122996 Api436216 Hs. 191715 ESTs, Weakly similar to ZN91_HUMAN ZINC 5. 10 128242 AA992626 Hs. 269755 ESTs, Moderately similar to ALU5_HUMAN A 5. 10 112374 NM 016323 Hs. 26663 cyclin-E binding protein 1 5. 10 124506 BE273688 Hs. 182447 heterogeneous nudearribonudeoprotein 5. 10 104216 AB002313 Hs. 3989 plexin B2 5. 09 135051 AI272141 Hs. 83484 SRY (sex determining region Y)-box 4 5. 08 131629 Z45794 Hs. 238809 ESTs 5. 08 111722 R23924 Hs. 23596 EST 5. 07 107034 AF257770 Hs. 20930 poly (rC)-binding protein 4 5. 06 110243 H26683 gb : yl14g03. s1 Scares breast 2NbHBst Homo 5. 05 125837 AW968123 Hs. 333513 small inducible cytokine subfamily E, me 5. 05 130300 X58288 Hs. 154151 protein tyrosine phosphatase, receptor t 5. 05 103967 AL120051 Hs. 144700 ephrin-B1 5. 04 112678 A1418466 Hs. 33665 ESTs 5. 03 124963 F06600 Hs. 101375 Homo sapiens mR ; cD DKFZp434H205 (fr 5. 03 131379 AK001123 Hs. 26176 hypothetical protein FLJ10261 5. 03 109451 N32264 Hs. 44330 ESTs 5. 02 101396 BE267931 Hs. 78996 proliferating cell nuclear antigen 5. 02 131038 W87778 Hs. 169388 hypothetical protein DKFZp761H2024 5. 01 101208 L25081 Hs. 179735 ras homolog gene family, member C 5. 01 104973 NM015310 Hs. 6763 KIAA0942 protein 4. 99 103141 X66113 Hs. 75584 polymyosi6slscleroderma autoantigen 2 (4. 98 111260 AB033035 Hs. 51965 KIAA1209 protein 4. 98 128142 T67162 Hs. 135127 ESTs, Weakly similar to unmed protein 4. 98 113857 AW243158 Hs. 5297 DKFZP564A2416 protein 4. 96 105292 AF128542 Hs. 166846 polymerase (D directed), epsilon 4. 96 114341 AF270491 Hs. 28249 hepatocellularcarcinoma-associated anti 4. 95 100615 W32474 Hs. 301746 RAP2A, memberofRASoncogenefamily 4. 95 103208 AW411340 Hs. 31314 retinoblastoma-binding protein 7 4. 95 121121 AA399371 Hs. 189095 similar to SALL1 (sal (Drosophila)-like 4. 95 125321 T86652 Hs. 178294 ESTs 4. 95 101145 L13210 Hs. 79339 lectin, galactoside-binding, soluble, 3 4. 95 100551 M73980 Hs. 129053 Homo sapiens NOTCH 1 (N1) mR, complete 4. 93 126182 AA721331 Hs. 293771 ESTs 4. 93 127925 AA805151 Hs. 3628 mitogen-ac6vated protein kise kise 4. 93 133969 AA669112 Hs. 78 GA-binding protein transcription factor, 4. 93 120873 AA358015 gb : EST66864 Fetal lung III Homo sapiens 4. 92 125219 A1804331 Hs. 99423 ATP-dependent R helicase 4. 91 102790 BE245277 Hs. 154196 E4F transcription factor 1 4. 90 129486 NM 005754 Hs. 220689 Ras-GTPase-activaWng protein SH3-domain 4. 90 130381 L47345 Hs. 155202 transcription elongation factor B (Sill) 4. 89 132389 AA310393 Hs. 190044 ESTs 4. 88 100260 D38491 Hs. 322478 KtM0117protein 4. 88 109585 N59650 Hs. 27252 ESTs 4. 88 111603 R11529 Hs. 20634 EST 4. 88 120514 AA258335 gb : zr59bO2. s1 Soares NhHMPu_S1 Homo sapi 4. 88 130314 NM014674 Hs. 154332 KIAA0212 gene product 4. 86 108958 AF142482 Hs. 203846 TEA domain family member 3 4. 86 126603 W86610 Hs. 185736 ESTs 4. 85 100406 A1962060 Hs. 118397 AE-binding protein 1 4. 85 116238 AV660717 Hs. 47144 DKFZP586N0819 protein 4. 84 105288 N99673 Hs. 3585 ESTs, Weakly similar to AF126741 DJ 4. 83 118753 AA346206 Hs. 50471 ESTs, Weakly similar to T14267 Xin prote 4. 82 113070 AB032977 Hs. 6298 KIAA1151 protein 4. 81 107908 AF087999 Hs. 42826 ESTs 4. 80 119678 A1658666 Hs. 6106 R binding motif protein 4 4. 80 100415 D86970 Hs. 75822 TGFB1-induced anti-apoptotic factor 1 4. 79 128360 F12374 gb : HSC39B101 nommalizedinfantbraincDN 4. 78 133101 AK000299 Hs. 180952 dyctin4 (p62) 4. 78 103507 AJ000512 Hs. 296323 serum/glucocorticoid regulated kise 4. 78 107666 AA010611 Hs. 60418 EST 4. 78 108030 A1378523 Hs. 62011 ESTs 4. 78 131479 D86181 Hs. 273 galactosylceramidase (Krabbe disease) 4. 78

133140 AF180681 Hs. 6582 Rho guanine exchange factor (GEF) 12 4. 78 134654 AK001741 Hs. 8739 hypothetical protein FLJ10879 4. 78 106288 AB037742 Hs. 24336 KIAA1321 protein 4. 76 101524 NM 000448 Hs. 73958 recombifion activating gene 1 4. 75 113095 AA828380 Hs. 126733 ESTs 4. 75 114924 A1338053 Hs. 87329 HSPC072 protein 4. 75 127543 AK000787 Hs. 157392 Homo sapiens cD FLJ20780 fis, clone CO 4. 75 115866 AW062629 Hs. 52081 KIAA0867 protein 4. 75 101382 AU076772 Hs. 1279 complementcomponent1, rsubcomponent 4. 74 126509 R47400 Hs. 23850 ESTs 4. 74 127930 AA809672 Hs. 123304 ESTs 4. 73 127824 Ai911516 Hs. 127811 ESTs 4. 73 110049 H12449 Hs. 31159 EST, Weakly similar to ALUB_HUMAN ! ! ! ! A 4. 73 127115 H77859 Hs. 65450 reticulon 4 4. 73 104727 N81203 Hs. 20047 zinc finger protein, subfamily 2A (FYVE 4. 72 127532 AJ003429 gb : AJ003429 Selected chromosome 21 cD 4. 71 127304 A1741577 Hs. 99962 proteoglycan 2, bone marrow (tural kil 4. 70 105409 AW505076 Hs. 301855 DiGeorge syndrome critical region gene 8 4. 70 114969 AW162998 Hs. 24684 KIAA1376 protein 4. 70 115125 AA193588 Hs. 85888 ESTs 4. 70 118348 AW408586 Hs. 91052 ESTs, ModeratetysimiiartoALU5_HUMANA 4. 70 123130 AA487200 gb : ab19f02. s1 Stratagene lung (937210) H 4. 70 130881 AA809875 Hs. 25933 ESTs 4. 70 132074 AA478486 Hs. 3852 KIAA0368 protein 4. 70 106897 AF039023 Hs. 167496 RAN binding protein 6 4. 69 131121 AA120865 Hs. 23136 ESTs 4. 69 116046 BE395293 Hs. 94491 hypothetical protein FLJ20297 4. 68 112868 AW388359 Hs. 10667 ESTs 4. 68 116877 AA708958 Hs. 168732 ESTs 4. 68 131241 BE501914 Hs. 24654 Homo sapiens cD FLJ11640 fis, clone HE 4. 68 132027 AF151020 Hs. 181444 hypothetical protein 4. 68 133323 BE336654 Hs. 70937 H3histonefamily, memberA 4. 68 114269 AA176769 Hs. 23450 mitochondrial ribosomal protein S25 4. 67 122713 A1089443 Hs. 99436 ESTs 4. 67 133571 BE515037 Hs. 177556 melanoma antigen, family D, 1 4. 66 134453 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 4. 66 115510 BE299339 Hs. 72249 three-PDZ containing protein similar to 4. 66 115322 L08895 Hs. 78995 MADS box transcripGon enhancerfactor 2 4. 66 129315 NM 014563 Hs. 174038 spondyloepiphyseal dysplasia, late 4. 65 104674 A. 935962 Hs. 26289 ESTs 4. 65 106276 AA625947 Hs. 25750 ESTs 4. 65 108216 AA524743 Hs. 44883 ESTs 4. 65 120376 AA227469 gb : zr18a07. s1 Stratagene NT2 neurol pr 4. 65 121743 AA397636 gb : zt79e09. r1 Soares testis_NHT Homo sap 4. 65 128011 A1347067 Hs. 124636 ESTs 4. 65 123454 AA868510 Hs. 112496 ESTs 4. 64 103409 NM_004454 Hs. 43697 ets variant gene 5 (ets-related molecule 4. 64 120484 AA253170 Hs. 96473 EST 4. 63 127046 AA321948 Hs. 293968 ESTs 4. 63 133184 AA001021 Hs. 6685 thyroid hormone receptor interactor 8 4. 63 123184 BE247767 Hs. 18166 KIAA0870 protein 4. 62 106627 AK000706 Hs. 15125 hypothetical protein FLJ20699 4. 61 115475 AB033085 Hs. 40193 hypothetical protein KIAA1259 4. 61 119468 AI911535 Hs. 6657 hypothetical protein bK1048E9. 5 4. 59 133662 BE409053 Hs. 299629 peroxisomal long-chain acyl-coA thioeste 4. 58 113941 AA531016 Hs. 22399 hypothetical protein FLJ14824 4. 58 131590 R46277 Hs. 250638 Homo sapiens mR full length insert cDN 4. 58 128795 AA531287 Hs. 105805 ESTs 4. 58 116480 C14088 Hs. 169476 glyceraldehyde-3-phosphate dehydrogese 4. 58 111713 C75253 Hs. 220950 ESTs 4. 58 113721 AF143885 Hs. 18190 EST 4. 57 111657 R07364 Hs. 268667 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 56 102009 BE245149 Hs. 82643 protein tyrosine kise 9 4. 55 135242 At583187 Hs. 9700 cyclin E1 4. 55 127580 BE548749 Hs. 148016 ESTs 4. 55 109785 ABC11131 Hs. 12376 piccolo (presyptic cytomatrix protein) 4. 53 109700 F09609 gb : HSC33H092 nommatized infant brain cDN 4. 53 124882 AI698652 Hs. 101539 ESTs 4. 53 131765 AW381270 Hs. 194110 hypothetical protein PRO2730 4. 53 115684 NM 006577 Hs. 284284 ESTs, Highly similar to beta-1, 3-N-acety 4. 52 102034 Ai903474 Hs. 230 fibromodulin 4. 52 109776 R43665 Hs. 12257 ESTs 4. 50 111650 R16722 Hs. 124246 ESTs 4. 50 132993 AB023154 Hs. 62264 KIAA0937 protein 4. 49 129017 AA115333 Hs. 107968 ESTs 4. 49 132902 A1936442 Hs. 59838 hypothetical protein FLJ10808 4. 48 114814 AB006622 Hs. 182536 KIAA0284 protein 4. 48 120839 AA348913 gb : EST55442 infant adreigiandii Homo 4. 48 101434 AV650066 Hs. 1430 coagulation factor XI (plasma thrombopla 4. 48 102018 U03398 Hs. 1524 tumor necrosis factor (ligand) superfami 4. 48 104619 AA001635 Hs. 287414 transcriptioi intermediary factor 1 ga 4. 48 106716 AA931198 Hs. 238928 HT002 protein ; hypertension-related calc 4. 48 126020 H79863 Hs. 114243 ESTs 4. 48

119899 A1057404 Hs. 58698 ESTs 4. 47 115582 AW245047 Hs. 136164 cutaneous T-cell lymphoma-associated tum 4. 46 125695 W22529 Hs. 30942 ephrin-B2 4. 46 105715 BE621800 Hs. 29444 putative small membrane protein NID67 4. 45 117169 R87866 Hs. 95120 ESTs, Weakiy similar to HZHU hemoglobin 4. 45 102757 AW955454 Hs. 30942 ephrin-B2 4. 45 120637 AA811804 gb : ob39aO5. s1 NCI_CGAP_GCB1 Homosapiens 4. 45 131579 N62922 Hs. 29088 ESTs 4. 45 135287 U82670 Hs. 9786 zinc finger protein 275 4. 45 112540 R69751 gb : yi40a10. s1 Soares placenta Nb2HP Homo 4. 45 125724 AL360190 Hs. 295978 Homo sapiens mR full length insert cDN 4. 44 115498 AA291070 gb : zs46aO8. s1 NCI_CGAP_GCB1 Homosapiens 4. 43 102263 U29171 Hs. 75852 casein kise 1, delta 4. 43 124312 H94647 Hs. 102329 ESTs 4. 43 112366 AF035318 Hs. 12533 Homo sapiens clone 23705 mR sequence 4. 43 115955 AF263613 Hs. 44198 intracellularmembrane-associatedcalciu 4. 43 103562 NM 002702 Hs. 2815 POU domain, class 6, transcription facto 4. 42 100169 AL037228 Hs. 82043 D123 gene product 4. 40 108928 AA143802 Hs. 71781 ESTs 4. 40 125908 AF265555 Hs. 250646 baculoviral IAP repeat-containing 6 4. 40 126996 BE161065 Hs. 167531 me6hy ! crotonoyl-CoenzymeAcarboxylese2 4. 40 129512 T88845 Hs. 112200 ESTs, Weakly similar to ALU7_HUMAN ALU S 4. 40 134570 U66615 Hs. 172280 SWI/SNF related, matrix associated, acfi 4. 40 135073 W55956 Hs. 94030 Homo sapiens mR, cD DKFZp586E1624 (f 4. 40 105011 BE091926 Hs. 16244 mitotic spindle coiled-coil related prot 4. 40 128793 AB011125 Hs. 105749 KIAA0553 protein 4. 40 107292 BE166479 Hs. 4789 Homo sapiens serologically defined breas 4. 38 126144 H84455 Hs. 40639 ESTs 4. 38 130783 X07282 Hs. 171495 retinoic acid receptor, beta 4. 38 135192 U83993 Hs. 321709 purinergic receptor P2X, ligand-gated io 4. 38 100284 D43767 Hs. 66742 small inducible cytokine subfamily A (Cy 4. 37 117269 N21621 Hs. 91142 KH-type splicing regulatory protein (FUS 4. 36 104261 AW248364 Hs. 5409 R polymerase I subunit 4. 35 108609 BE409857 Hs. 69499 hypothetical protein 4. 35 126319 D81689 gb : HUM184E05B Human fetal brain (TFujiwa 4. 35 127445 AA906286 Hs. 193942 ESTs 4. 35 130772 BE270640 Hs. 19192 cyclin-dependent kise 2 4. 35 134625 AA977638 Hs. 184389 ESTs 4. 35 135397 L14922 Hs. 166563 replication factor C (activator 1) 1 (14 4. 35 128070 AA886944 Hs. 303908 ESTs 4. 35 135046 AI494054 Hs. 93589 hypothetical protein DKFZp564B1162 4. 33 101881 NM 004957 Hs. 754 folyipolyglutamate synthase 4. 33 129838 AB007863 Hs. 185140 KIAA0403 protein 4. 33 130974 NM003528 Hs. 2178 H2B histone family, member Q 4. 33 107763 AA018220 Hs. 106730 chromosome 22 open reading frame 3 4. 32 129818 T71092 Hs. 172572 hypothetical protein FLJ20093 4. 31 129407 AL137597 Hs. 11114 hypotheticalprotein dJ1181N3. 1 4. 30 110846 BE277343 Hs. 297875 endoplasmic reticulum chaperone SIL1, ho 4. 30 111433 R01452 Hs. 40193 hypothetical protein KIAA1259 4. 30 114860 AL157545 Hs. 42179 bromodomain and PHD finger containing, 3 4. 30 115853 AW978561 Hs. 191548 ESTs 4. 30 116165 AI184751 Hs. 75874 pregncy-associated plasma protein A 4. 30 126911 AA428049 Hs. 1501 syndecan 2 (heparan sulfate proteoglycan 4. 30 131230 NM005865 Hs. 274407 protease, serine, 16 (thymus) 4. 30 100349 D64110 Hs. 77311 BTG family, member 3 4. 29 100175 BE258769 Hs. 32500 acetyl-Coenzyme A acyltransferase 2 (mit 4. 29 105335 AW291165 Hs. 25447 ESTs 4. 29 122507 BE567620 Hs. 99210 ESTs 4. 28 105397 AA814807 Hs. 7395 hypothetical protein FLJ23182 4. 28 133674 AW851121 Hs. 75497 Homo sapiens cD : FLJ22139 fis, clone H 4. 28 102826 NM 007274 Hs. 8679 cytosolic acyl coenzyme A thioester hydr 4. 28 103272 Nu-006680 Hs. 2838 malic enzyme 3, DP (+)-dependent, mitoc 4. 28 111887 R38635 Hs. 12328 KIAA1005 protein 4. 28 120336 N85785 Hs. 181165 eukaryotic translation elongation factor 4. 28 133736 D49958 Hs. 75819 glycoprotein M6A 4. 28 130356 AF127577 Hs. 155017 nuclear receptor interacting protein 1 4. 27 119830 AW054922 Hs. 53478 Homo sapiens cD FLJ12366 fis, clone MA 4. 27 106758 AB014564 Hs. 22616 KIAA0664 protein 4. 25 109709 F09749 Hs. 187405 ESTs 4. 25 110463 H52931 Hs. 165067 ESTs 4. 25 124472 N52517 Hs. 102670 EST 4. 25 109770 R40322 Hs. 248420 ESTs, Moderately similar to A47582 B-cel 4. 24 131487 F13036 Hs. 27373 Homo sapiens mR ; cD DKFZp56401763 (f 4. 23 107216 D51069 Hs. 211579 melanoma cell adhesion molecule 4. 23 123562 AA177088 Hs. 190065 ESTs 4. 23 125986 W02410 Hs. 205555 ESTs 4. 23 126221 N20514 Hs. 172965 ESTs 4. 23 127092 T26985 gb : NiBT065H01R ! nfant brain, LLNL array 4. 23 132349 AW975654 Hs. 181286 serine protease inhibitor, Kazal type 1 4. 23 118946 N92834 gb : zb67f03. Soares_fetaJung_NbHL19W 4. 22 101531 A1199711 Hs. 576 fucosidase, alpha-L-1, 6ssue 4. 21 105322 T87179 Hs. 16346 ESTs, WeaklysimilartoS57447HPBR11-7 4. 21 104219 AB002323 Hs. 7720 dynein, cytoplasmic, heavy polypeptide 1 4. 20

102825 BE262386 Hs. 7137 clones 23667 and 23775 zinc finger prote 4. 20 103571 A1675749 Hs. 211608 nucleoporin 153kD 4. 20 106942 AA995351 Hs. 31314 retinoblastoma-binding protein 7 4. 20 112685 R87650 Hs. 33439 ESTs, Weakly similar to AW1_HUMAN ALU S 4. 20 123107 AA225048 Hs. 104207 ESTs 4. 20 132659 Z75190 Hs. 54481 low density lipoprotein receptor-related 4. 20 130084 At929377 Hs. 173724 creatine kise, brain 4. 19 114553 BE219860 Hs. 22505 hypothetical protein Fla 10159 4. 18 129628 U38945 Hs. 1174 cyclin-dependent kise inhibitor 2A (me 4. 18 102266 U29725 Hs. 3080 mitogen-ac6vated protein kise 7 4. 18 110637 A1241470 Hs. 268982 ESTs 4. 18 127520 T51239 gb : yb20d12. s1 Strataçqenefetatspteen (9 4. 18 130322 Nu-014247 Hs. 154545 PDZ domain containing guanine nucleotide 4. 17 104768 D82319 Hs. 11056 RALBP1 protein 4. 17 123360 AA532718 Hs. 178604 ESTs 4. 17 133110 AA808177 Hs. 65228 ESTs 4. 16 130923 H96115 Hs. 21293 UDP-N-acteylglucosamine pyrophosphorylas 4. 16 109878 BE620775 Hs. 4866 Homo sapiens cD FLJ14387 fis, clone HE 4. 16 119265 BE539706 Hs. 285363 ESTs 4. 16 124214 H58608 Hs. 151323 ESTs 4. 15 106193 AA057478 Hs. 23272 ESTs 4. 15 105169 BE245294 Hs. 180789 S164 protein 4. 15 132304 AA610002 Hs. 44296 hypothetical protein FU22324 4. 15 131600 Nul004377 Hs. 29331 camiane pamitoyltransferase 1, muscte 4. 14 131365 M93415 Hs. 26014 aktivin A receptor, type 11 4. 14 121993 AW297880 Hs. 98661 ESTs 4. 14 110779 AI391472 Hs. 12561 ESTs, Highiy similar to C212HUMAN 28. 3 4. 13 126383 AB032977 Hs. 6298 KIAA1151 protein 4. 13 104446 AF084555 Hs. 7351 cyclic AMP phosphoprotein, 19 kD 4. 13 131475 AA992841 Hs. 27263 KIAA1458 protein 4. 13 128933 NM 002050 Hs. 334695 GATA-binding protein 2 4. 12 113141 AI493276 Hs. 9187 ESTs 4. 11 134833 L20965 Hs. 89901 phosphodiesterase 4A, cAMP-specific (dun 4. 11 106461 A1630759 Hs. 17481 Homo sapiens clone 24606 mR sequence 4. 10 128056 At990131 Hs. 276973 potassium large conductance calcium-acfi 4. 10 114757 AW970579 Hs. 291031 ESTs 4. 10 134653 A1765883 Hs. 87385 ESTs 4. 09 100472 D90084 Hs. 1023 pyruvatedehydrogese (iipoamide) a) pha 4. 08 103102 X61177 Hs. 68876 interleukin 5 receptor, alpha 4. 08 106779 BE276013 Hs. 172364 Homo sapiens mR for FLJ00086 protein, 4. 08 133615 M62843 Hs. 75236 ELAV (embryonic lethal, abnormal vision, 4. 08 130178 U20982 Hs. 1516 insulin-like growth factor-binding prote 4. 07 124659 Api680737 Hs. 289068 Homo sapiens cD FLJ11918 fis, clone HE 4. 07 127861 AW295020 Hs. 198529 ESTs 4. 07 112129 AB037715 Hs. 183639 hypothetical protein FLJ10210 4. 07 100918 AK001335 Hs. 31137 protein tyrosine phosphatase, receptor t 4. 06 124677 R01073 gb : ye84c03. s1 Soaresfeta ! ! iverspReen 4. 05 102722 F13271 Hs. 79981 Human clone 23560 mR sequence 4. 05 111117 AB037721 Hs. 173871 KIAA1300 protein 4. 05 122506 AA449120 Hs. 99209 ESTs 4. 05 126392 Ai356294 Hs. 3280 caspase 6, apoptosis-related cysteine pr 4. 05 130760 AW379130 Hs. 18953 phosphodiesterase 9A 4. 05 104220 AB002324 Hs. 301094 K ! M0326 protein 4. 05 112774 R95770 Hs. 35455 ESTs 4. 04 111128 AW505364 Hs. 19074 LATS (large tumor suppressor, Drosophila 4. 04 113146 BE151985 Hs. 5722 hypothetical protein FU23316 4. 04 124940 AF068846 Hs. 103804 heterogeneous nuclear ribonucleoprotein 4. 03 105498 H68279 Hs. 24937 transformer-2 alpha (htra-2 alpha) 4. 03 112631 R82040 gb : yj06b06. s1 Soares placenta Nb2HP Homo 4. 03 118244 N62516 Hs. 48556 ESTs 4. 03 118720 N73515 gb : za49dO7. s1 Soaresfetativerspleen 4. 03 129232 R98881 Hs. 109655 sex comb on midleg (Drosophila)-like 1 4. 03 134192 H01345 Hs. 24139 Homo sapiens cD : FLJ23137 fis, clone L 4. 03 131893 BE336886 Hs. 3416 adipose differentia6on-related protein 4. 02 116793 T77781 gb : yd20a11. s1 Soaresfetalliverspleen 4. 02 125674 AL036166 Hs. 323378 coated vesicle membrane protein 4. 01 116640 X89984 Hs. 211563 B-cet ! CLL/iymphoma 7A 4. 01 105057 AA134233 Hs. 336942 Homo sapiens cD : FLJ21488 fis, clone C 4. 00 105158 AW976357 Hs. 234545 hypothetical protein NUF2R 4. 00 116245 AB033107 Hs. 42796 KIAA1281 protein 4. 00 119946 AA932283 Hs. 58925 ESTs 4. 00 121975 AA740679 Hs. 98631 ESTs 4. 00 132037 AA352702 Hs. 332541 Homo sapiens, Similar to RIKEN cD 2700 4. 00 133669 NM006925 Hs. 166975 splicing factor, arginine/serine-rich 5 4. 00 109468 NM_015310 Hs. 6763 KIAA0942 protein 3. 99 106829 AW959893 Hs. 27099 hypothetical protein FLJ23293 similar to 3. 99 134682 AW882645 Hs. 88044 sprouty (Drosophila) homolog 1 (antagoni 3. 98 105966 AA142984 Hs. 5344 adaptor-related protein complex 1, gamma 3. 98 100448 AF234887 Hs. 57652 cadherin, EGF LAG seven-pass Gtype rece 3. 98 102589 AU076728 Hs. 8867 cysteine-rtch, angiogenic inducer, 61 3. 98 104146 AW880614 Hs. 146381 Rbindingmotifprotein. Xchromosome 3. 98 111465 A1968256 Hs. 15470 putative ring zinc finger protein NY-REN 3. 98 126499 AK001779 Hs. 110445 CGI-97 protein 3. 98

134388 AW405434 Hs. 82575 smaitnudearribonudeoproteinpoiypept 3. 98 105564 BE616694 Hs. 288042 hypothetical protein FU14299 3. 97 115206 AW183695 Hs. 186572 ESTs 3. 96 103853 AF272390 Hs. 111782 myosin5C 3. 96 110542 H58373 Hs. 332938 hypothetical protein MGC5370 3. 96 106797 A1768801 Hs. 169943 Homo sapiens cD FU13569 fis, clone PL 3. 96 130589 AL110226 Hs. 16441 DKFZP434H204 protein 3. 95 122788 A1828638 Hs. 99514 hypothetical protein FLJ20574 3. 95 104518 H20816 Hs. 112423 Homo sapiens mR ; cD DKFZp586. 1420 (t 3. 95 130640 NM_004753 Hs. 17144 short-chain dehydrogese/reductase 1 3. 95 110847 N30169 Hs. 279807 ESTs, Weakly similar to 2004399A chromos 3. 95 116156 AA461045 Hs. 50701 ESTs 3. 95 122096 AA431162 Hs. 98690 ESTs 3. 95 122160 At769281 Hs. 97439 ESTs 3. 95 123930 AA740878 Hs. 112982 ESTs 3. 95 126280 Z19417 gb : HSB26B122STRATAGENEHumanskeleta. m 3. 95 126547 U47732 Hs. 84072 transmembrane 4 superfamily member 3 3. 95 134757 AA913267 Hs. 211576 IL2-inducible T-cell kise 3. 95 117296 AL133427 Hs. 42506 Homo sapiens mR full length insert cDN 3. 95 112261 AL050297 Hs. 300861 ESTs, HighlysimilartoT08701 hypothe6 3. 95 112268 W39609 Hs. 22003 solutecanierfamily6 (neurotransmiüe 3. 94 131844 A1419294 Hs. 324342 ESTs 3. 94 101607 X60111 Hs. 1244 CD9 antigen (p24) 3. 94 121613 AA416879 Hs. 193195 ESTs, Weakly similar to 2109260A B cell. 3. 93 115815 AW905328 Hs. 180842 ribosomal protein L13 3. 93 125684 AW589427 Hs. 158849 Homo sapiens cD : FLJ21663 fis, clone C 3. 93 126783 AA083531 gb : zn09d10. s1 Stratagene hNT neuron (937 3. 93 129201 H18359 Hs. 109390 ESTs 3. 93 128954 AA346839 Hs. 209100 DKFZP434C171 protein 3. 92 122939 AA477141 gb : zu37g06. s1 Soares ovary tumor NbHOT H 3. 92 130348 AB032957 Hs. 210850 KIAA1131 protein 3. 92 125847 AW161885 Hs. 249034 ESTs 3. 91 120452 AL022328 Hs. 104335 hypothetical protein IMAGE3510317 3. 91 123143 AA487595 gb : aa95eO2. s1 Stratagenefeta. reS93 3. 91 105729 H46612 Hs. 293815 Homo sapiens HSPC285 mR, partial cds 3. 91 106605 AW772298 Hs. 21103 HomosapiensmR ; cDDKFZp564B076 (hr 3. 90 126714 AF114491 Hs. 137354 egf-like module containing, mucin-like, 3. 90 121611 M31669 Hs. 1735 inhibin, beta B (activin AB beta polypep 3. 90 120468 AW967675 Hs. 96487 ESTs, Highly similar to S08228 ribosomal 3. 90 101356 AW878229 Hs. 80642 sigitransducerandactivatoroftrans 3. 89 133668 L77964 Hs. 271980 mitogen-activated protein kise 6 3. 89 109114 BE622787 Hs. 84045 hypothetical protein FLJ20288 3. 88 115134 AW968073 Hs. 194331 ESTs, Mighty simi) artoA55713inosito) 3. 88 107850 AA022910 Hs. 295446 ESTs, Moderately similar to 810024C cyto 3. 88 130907 AA322866 Hs. 21107 neuroligin 3. 88 101879 AA176374 Hs. 243886 nuclear autoantigenic sperm protein (his 3. 88 104267 AF043244 Hs. 278439 nucleolar protein 3 (apoptosis repressor 3. 88 112232 BE253927 Hs. 24983 hypothetical protein from EUROIMAGE 2021 3. 88 113248 T63857 gb : yc16e01. s1Stratagene lung (937210) H 3. 88 114044 BE327427 Hs. 79953 ESTs 3. 88 115414 AA662240 Hs. 283099 AF15q14 protein 3. 88 129598 N30436 Hs. i 1556 Homo sapiens cD FLJ12566 fis, clone NT 3. 88 102134 AL036967 Hs. 2324 protamine 2 3. 87 106310 R98185 Hs. 17240 ESTs 3. 87 116470 At272941 Hs. 83484 SRY (sex determining region Y)-box 4 3. 86 110947 AW298410 Hs. 21475 ESTs 3. 85 115839 BE300266 Hs. 28935 transducin-likeenhancerofsplit1, hom 3. 85 103534 AW970672 Hs. 9247 protein kise, AMP-activated, alpha 1 c 3. 85 105209 AB023197 Hs. 227743 KIAA0980 protein 3. 85 108749 AA127017 Hs. 71052 ESTs 3. 85 110565 A1884970 Hs. 4983 ESTs 3. 85 110799 At089660 Hs. 323401 dpy-30-like protein 3. 85 117068 H91257 Hs. 41391 EST 3. 85 130956 NM_001135 Hs. 2159 aggrecan1 (chondroiSnsulfateproteogl 3. 85 102273 BE391815 Hs. 75981 ubiquitin specific protease 14 (tR-gua 3. 85 112960 AL110209 Hs. 6770 LCAT-like lysophospholipase 3. 84 114414 AW152166 Hs. 182113 ESTs 3. 84 109665 AA249439 Hs. 27027 hypothetical protein DKFZp762H1311 3. 84 106208 AK001674 Hs. 22630 cofactorrequiredforSp1 transcripbo 3. 84 122311 NM014913 Hs. 131915 KIAA0863 protein 3. 84 124271 AW293223 Hs. 8928 hypothetical protein FLJ20291 3. 83 106650 AL049951 Hs. 22370 Homo sapiens mR ; cD DKFZp56400122 (f 3. 83 112167 N99591 Hs. 25587 ESTs, WeaklysimilartoT00329hypothe6 3. 83 122354 AL157579 Hs. 153610 KIAA0751 gene product 3. 83 111462 R05296 gb : ye91e08. s1 Soaresfetalliverspleen 3. 81 128109 AW269421 Hs. 128093 ESTs 3. 81 127003 AW816515 Hs. 173540 ATPase, Class V, type 10D 3. 81 109210 AA669722 Hs. 272137 ESTs 3. 81 132543 BE568452 Hs. 5101 protein regulator of cytokinesis 1 3. 80 106827 AA457456 Hs. 11408 hypothetical protein FLJ20435 3. 80 124232 H63391 Hs. 339677 ESTs, Weakly similar to 38022 hypotheti 3. 80 126039 AL137523 Hs. 181102 p30DBCprotein 3. 80 128022 AW195569 Hs. 125906 ESTs 3. 80

132005 AA149707 Hs. 173091 ubiquitin-like 3 3. 79 131392 AA235153 Hs. 26320 TRABID protein 3. 79 131775 AB014548 Hs. 31921 KIAA0648 protein 3. 79 126257 N99638 gb : za39g11. r1 Soaresfetatliverspleen 3. 79 121950 AA429515 gb : zw75cO5. s1 Soares tesEs NHT Homo sap 3. 79 116067 AA454827 Hs. 293637 ESTs 3. 78 104658 AA360954 Hs. 27268 HomosapienscaFW21933fis, c ! oneH 3. 78 104493 AW960427 Hs. 79059 transforming growth factor, beta recepto 3. 77 100163 W44671 Hs. 124 gene predicted from cD with a complete 3. 77 116223 AF045458 Hs. 47061 unc-51 (C. elegans)-like kise 1 3. 77 120586 AL031778 Hs. 797 nudear transcription factory, alpha 3. 76 128764 AW024282 Hs. 104938 hypothetical protein MGC15906 3. 75 111574 A1024145 Hs. 188526 ESTs 3. 75 117396 W20128 Hs. 296039 ESTs 3. 75 119052 R10889 gb : yf38d02. s1Soaresfetalliverspleen 3. 75 121806 AA424313 Hs. 98402 ESTs 3. 75 122410 AA446854 Hs. 271004 ESTs, Weakly similar to 138022 hypothe6 3. 75 126638 AA649257 Hs. 188602 ESTs 3. 75 127879 AA768098 Hs. 189079 ESTs 3. 75 121095 AA320134 Hs. 196029 Homo sapiens mR for KIAA1657 protein, 3. 75 103430 BE564090 Hs. 20716 translocase of inner mitochondrial membr 3. 74 101230 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 3. 74 100200 H94688 Hs. 173737 ras-related C3 botalinum toxin substrate 3. 73 106913 Api219346 Hs. 86178 M-phase phosphoprotein 9 3. 73 110975 H17012 Hs. 14633 ESTs 3. 73 117314 N32498 Hs. 42829 ESTs 3. 73 118737 AA199686 gb : zq75g09. r1 StratagenehNTneuron (937 3. 73 124169 BE079334 Hs. 271630 ESTs 3. 73 124580 N68420 Hs. 107992 ESTs 3. 73 125747 NM_002884 Hs. 865 RAP1A, memberofRASoncogenefamily a73 124879 R73588 Hs. 101533 ESTs 3. 72 128527 AA504583 Hs. 101047 transcription factor 3 (E2A immunoglobul 3. 72 103644 M13305 Hs. 247787 opsin 1 (cone pigments), long-wave-sensi 3. 72 106044 N90344 Hs. 149436 kinesin family member 5B 3. 71 127867 C18530 gb : C18530 Human placenta cD (TFujiwara 3. 71 133828 T28472 Hs. 7655 U2 small nuclear ribonucleoprotein auxil 3. 71 107387 D86983 Hs. 118893 Melanoma associated gene 3. 71 104160 AA455706 Hs. 44581 heat shock protein hsp70-related protein 3. 71 106098 BE278344 Hs. 7970 DKFZP434B027 protein 3. 70 133691 M85289 Hs. 211573 heparan sulfate proteoglycan 2 (periecan 3. 70 120717 AA904681 Hs. 154434 ESTs, Weakly similar to unknown [H. sapie 3. 70 119263 T15977 gb : lB23281nfantbrån, BentoSoaresHom 3. 70 102305 AL043202 Hs. 90073 chromosome segregation 1 (yeast homolog) 3. 70 106566 BE298210 gb : 601118016F1 HMGC17Homosapiensc 3. 70 110708 N33878 Hs. 306117 KIAA0306 protein 3. 70 114357 R41677 Hs. 6107 Homo sapiens cD FLJ14839 fis, clone OV 3. 70 115285 AW972872 Hs. 293736 ESTs 3. 70 123034 AL359571 Hs. 44054 ninein (GSK3B interacting protein) 3. 70 126396 T06298 Hs. 153326 EST 3. 70 132597 Y11192 Hs. 5299 aldehyde dehydrogese 5 family, member 3. 70 105823 A1559444 Hs. 293960 ESTs 3. 70 102644 T59816 Hs. 173311 C18B11 homolog (44. 9kD) 3. 70 133513 AF136407 Hs. 7446 chromosome 6 open reading frame 5 3. 70 116450 A1654450 Hs. 47274 HomosapiensmR-cDDKFZp564B176 (fr 3. 69 104596 AF067804 Hs. 15423 hypothetical protein HDCMC04P 3. 69 133579 X75346 Hs. 75074 mitogen-activated protein kise-activat 3. 68 124556 N29317 Hs. 236463 Homo sapiens mR ; cD DKFZp58610521 (f 3. 68 120534 A1635113 Hs. 270366 ESTs, Weaklysimilartol78885serine/th 3. 68 103156 BE259039 Hs. 129953 Ewing sarcoma breakpointregion 1 3. 68 134992 AA464444 Hs. 5831 Ussue inhibitor of metalloproteise 1 3. 68 106730 BE467313 Hs. 260707 ESTs 3. 68 120880 AA360240 Hs. 97019 EST 3. 68 123731 AA609839 gb : ae62fO1. s1 Stratagenelung carcinoma 3. 68 126973 W46653 Hs. 251928 nuclear pore complex interacting protein 3. 67 103646 AW248439 Hs. 2340 junction piakoglobin 3. 67 116333 AF155827 Hs. 203963 hypothetical protein FLJ10339 3. 67 120922 AA481003 Hs. 97128 ESTs 3. 67 127407 AW089514 Hs. 279681 heterogeneous nuclear ribonucleoprotein 3. 67 106578 AA836381 Hs. 315111 nuclear receptor co-repressor/HDAC3 comp 3. 67 123000 At584156 Hs. 105640 Homo sapiens, clone MAGE : 4139775, mR 3. 67 101464 AA852431 Hs. 51299 DHdehydrogese (ubiquinone) flavopro 3. 67 101397 M26380 Hs. 180878 lipoprotein lipase 3. 67 131135 NM016569 Hs. 267182 TBX3-iso protein 3. 66 106112 AL117518 Hs. 3686 KIAA0978 protein 3. 66 123974 Nu015678 Hs. 3821 neurobeachin 3. 66 127742 AW293496 Hs. 180138 ESTs 3. 66 112908 BE281000 Hs. 3530 TLS-associatedserine-arginineprotein2 3. 66 131802 AL137406 Hs. 296356 Homo sapiens mR ; cD DKFZp434Ml62 (fr 3. 65 135162 At187925 Hs. 95667 F-box protein 30 3. 65 124984 BE313210 Hs. 223241 eukaryotic transla6on elongation factor 3. 65 118844 AL035364 Hs. 50891 hypothetical protein 3. 65 125429 Aï023654 Hs. 114191 ESTs 3. 65 125596 R25698 gb : yg44h11. r2 Soares infant brain 1NIB H 3. 65

125792 AA496205 Hs. 193700 Homo sapiens mR ; cD DKFZp58610324 (f 3. 65 126965 At470523 Hs. 139336 ATP-binding cassette, sub-family C (CFTR 3. 65 130776 AF167706 Hs. 19280 cysteine-rich motor neuron 1 3. 65 131949 AK000010 Hs. 258798 hypothetical protein FLJ20003 3. 65 116612 C14904 Hs. 45184 Homo sapiens cD FLJ12284 fis, clone MA 3. 65 123749 AA609949 Hs. 112790 EST 3. 65 134203 AA161219 Hs. 799 diphtheriatoxinreceptor (heparin-bindi 3. 64 133605 AL038165 Hs. 75187 transiocase of outer mitochondriatmembr 3. 64 109235 At381800 Hs. 300684 calcitonin gene-related peptide-receptor 3. 64 125447 A1582222 Hs. 128686 ESTs 3. 63 122942 A1277829 Hs. 111862 KIAA0590 gene product 3. 63 122748 AA458822 Hs. 193815 ESTs 3. 63 103840 AW975861 Hs. 47367 KIAA1785 protein 3. 63 105333 AA234831 Hs. 246112 KIAA0788 protein 3. 63 108807 A1652236 Hs. 49376 hypothetical protein FLJ20644 3. 63 114699 AA127386 gb : zn90dO9. r1 Stratagene lung carcinoma 3. 63 126040 Z28444 Hs. 24119 Homo sapiens mR ; cD DKFZp586G2222 (f 3. 63 131028 Api879165 Hs. 2227 CCAAT/enhancerbinding protein (C/EBP), 3. 63 131710 NM 015368 Hs. 30985 pannexin 1 3. 63 100164 AW372032 Hs. 173714 MORF-related gene X 3. 62 120837 BE149656 Hs. 306621 Homo sapiens cD FLJ11963 fis, clone HE 3. 62 131089 Z42645 Hs. 22870 Homo sapiens mR full length insert cDN 3. 62 126428 AA412436 Hs. 301985 ESTs 3. 62 129148 AW501216 Hs. 108945 KIAA0515 protein 3. 61 102337 A1814663 Hs. 170133 forkhead box 01A (rhabdomyosarcoma) 3. 61 104520 A1702384 Hs. 76925 hypotheGcalprotein FLJ14981 3. 60 112954 AA928953 Hs. 6655 Homo sapiens EST from clone 208499, full 3. 60 125197 AF086270 Hs. 278554 heterochromafin-like protein 1 3. 60 128124 A1125748 Hs. 130194 ESTs 3. 60 129553 AW015763 Hs. 113065 ESTs 3. 60 123998 AA203429 Hs. 79474 tyrosine3-monooxygese/tryptophan5-mo 3. 60 128835 AK001731 Hs. 106390 Homo sapiens mR ; cD DKFZp586H0924 (f 3. 59 129226 BE222494 Hs. 180919 inhibitorofDbinding2, domintneg 3. 59 135131 AI582743 Hs. 94953 Homo sapiens, Similar to complement comp 3. 59 128955 AA775076 Hs. 185807 Homo sapiens, Similar to PR00478 protein 3. 58 100225 D28539 Hs. 167185 glutamate receptor, metabotropic 5 3. 58 101572 AA437199 Hs. 656 cell division cycle 25C 3. 58 102277 U31099 Hs. 158326 prostaglandin D2 receptor (DP) 3. 58 103667 Z80788 Hs. 247815 H4 histone family, member L 3. 58 112373 AW963357 Hs. 7847 ESTs 3. 58 119284 AL041224 Hs. 65379 ESTs 3. 58 125422 AA903229 Hs. 153717 ESTs 3. 58 126381 M76665 Hs. 275215 hydroxysteroid (11-beta) dehydrogese 1 3. 58 129168 A1132988 Hs. 109052 chromosome 14 open reading frame 2 3. 58 123133 AA487264 Hs. 154974 Homo sapiens mR ; cD DKFZp667N064 (fr 3. 57 128789 AW368576 Hs. 139851 caveo. in 2 3. 57 104172 AA476418 gb : zx02a12. s1 Soares_totàfetus_Nb2HF8_ 3. 57 134263 AW973443 Hs. 8086 R (guanine-7-) methyltransferase 3. 57 101759 M80244 Hs. 184601 solutecanierfami. y7 (ca6unicamino 3. 57 104942 NM016348 Hs. 10235 chromosome 5 open reading frame 4 3. 56 123443 BE244537 Hs. 167382 triuretic peptide receptor Alguanylate 3. 56 110707 Api239832 Hs. 15617 ESTs, Weakly similar to AW4_HUMAN ALU S 3. 55 106787 A1492261 Hs. 32450 ESTs 3. 55 112940 AK001757 Hs. 281348 hypothetical protein FLJ10895 3. 55 115301 T11832 Hs. 127797 Homo sapiens cD FLJ11381 fis, clone HE 3. 55 125978 N66843 Hs. 35608 ESTs 3. 55 128002 A1985897 Hs. 125293 ESTs 3. 55 119847 H81136 Hs. 334604 Homo sapiens mR for KIAA1870 protein, 3. 55 134595 NM_002401 Hs. 29282 mitogen-activated protein kise kise 3. 55 121309 AA293834 Hs. 97312 ESTs 3. 54 122679 AA811286 Hs. 192837 ESTs, Weakly similar to ALU5_HUMAN ALU S 3. 54 106061 AA565356 Hs. 13250 ESTs 3. 54 127207 AA377165 Hs. 44833 ESTs 3. 54 129563 AF119664 Hs. 27299 transcrip6ol regulator protein 3. 54 105951 R48700 Hs. 20733 Homo sapiens cD : FLJ22356 fis, clone H 3. 53 115643 AA404276 Hs. 123253 hypothetical protein FLJ22009 3. 53 130473 U11690 Hs. 1572 faciogenitaldysplasia (Aarskog-Scottsy 3. 53 104246 AF016032 Hs. 201377 lysosomal 3. 53 120562 BE244580 Hs. 302267 hypothetical protein FLJ10330 3. 53 101211 AA355357 Hs. 283429 SMC (mouse) homolog, X chromosome 3. 53 100774 J05581 Hs. 89603 mucin 1, transmembrane 3. 53 108407 AA075519 gb : zm87hO9. s1 Stratageneovariancancer 3. 53 113538 AI554947 Hs. 15167 ESTs, Weakly similar to S37482 finger pr 3. 53 113876 At799751 Hs. 5635 ESTs 3. 53 110731 NM014899 Hs. 188006 KIAA0878 protein 3. 52 125845 AK001440 Hs. 131840 hypothetical protein FLJ10578 3. 51 112945 AW138458 Hs. 20787 Homo sapiens cD : FLJ21686 fis, clone C 3. 51 131686 NM012296 Hs. 30687 GRB2-associated binding protein 2 3. 51 125413 At887951 Hs. 74566 dihydropyrimidise-like 3 3. 51 129360 AJ000534 Hs. 110708 sarcoglycan, epsilon 3. 50 128819 R38007 Hs. 77578 ubiquitin specific protease 9, X chromos 3. 50 101973 U41514 Hs. 80120 UDP-N-acetyl-alpha-D-galactosamine : polyp 3. 50 103616 NM_002647 Hs. 32971 phosphoinositide-3kise, class 3 3. 50

105535 AI459519 Hs. 297681 serine (orcysteine) proteiseinhibito 3. 50 118767 A1038653 Hs. 50500 ESTs 3. 50 126634 AW361109 Hs. 43627 SRY (sex determining region Y)-box 22 3. 50 130851 R66282 Hs. 20247 ESTs, Weakly similar to S65657 alpha-I C-3. 50 134353 AL138201 Hs. 82120 nuclear receptor subfamily 4, group A, m 3. 50 111394 AA412227 Hs. 16131 hypothetical protein FLJ12876 3. 50 102696 BE540274 Hs. 239 forkhead box M1 3. 49 113037 R17268 Hs. 259873 axol transport of sypuc vesicles 3. 49 111028 H59346 Hs. 30151 ESTs, Weakly similar to 138022 hypotheu 3. 49 131688 A1935413 Hs. 30692 p21 (CDKN1A)-æ6vated kise 2 3. 49 115613 AW136951 Hs. 173946 hypothetical protein FLJ10486 3. 48 116975 H81076 Hs. 269001 ESTs 3. 48 100210 D26361 Hs. 3104 KIAA0042 gene product 3. 48 110147 H18700 Hs. 268799 ESTs 3. 48 115600 AA081395 Hs. 42173 Homo sapiens cD FUI0366 fis, clone NT 3. 48 119088 R39261 Hs. 90790 Homo sapiens cD : FU22930 fis, clone K 3. 48 120347 AA211068 Hs. 120247 nuclear fragile X mental retardation pro 3. 48 122702 A1220089 Hs. 99439 ESTs 3. 48 125552 H09701 Hs. 278366 ESTs, Weakly similar to 138022 hypotheu 3. 48 126461 A1381659 Hs. 267086 ESTs 3. 48 128572 AA933022 Hs. 256583 interteukin enhancer binding factor 3, 9 3. 48 118397 BE139479 Hs. 161492 ESTs 3. 47 127999 AW978827 Hs. 69851 nucleolar protein family A, member 1 (H/3. 47 132066 A1929392 HS. 181195 DJ (Hsp40) homolog, subfamily B, membe 3. 47 105693 BE250951 Hs. 181368 U5 snRNP-specific protein (220 kD), orth 3. 47 128874 H06245 Hs. 106801 ESTs, WeaMysimi) artoPC4259ferritin 3. 46 119984 AA230228 Hs. 59197 ESTs 3. 46 104000 Ai146527 Hs. 80475 polymerase (R) 11 (D directed) polyp 3. 46 101488 BE547216 Hs. 181128 ELK1 member of ETS oncogene family 3. 46 101045 J05614 gb : Húman proliferaUng cel ! nuclear an6 3. 46 120149 AA227609 Hs. 94834 ESTs 3. 46 107025 AA825523 Hs. 21255 ESTs, Weakly similar to 138022 hypotheti 3. 45 101716 AF050658 Hs. 2563 tachykinin, precursor 1 (substance K, su 3. 45 102899 A1815559 Hs. 75730 sigl recognition paricle receptor ('d 3. 45 123075 AW293133 Hs. 101340 ESTs, Weakly similar to A42442 integrin 3. 45 124695 AA594979 Hs. 239307 tyrosyl-tRsynthetase 3. 45 127669 N28989 Hs. 22891 solute carrier family 7 (cationic amino 3. 45 129793 AW207000 Hs. 126857 Homo sapiens cD FLJ12936 fis, clone NT 3. 44 120095 AA693774 Hs. 59601 ESTs 3. 44 110915 BE092285 Hs. 29724 hypothetical protein FLJ13187 3. 43 130542 U64675 Hs. 179825 RAN binding protein 2-like 1 3. 43 100488 BE273749 Hs. 752 FK506-binding protein 1A (12kD) 3. 43 115027 AA743331 Hs. 272572 hemoglobin, alpha2 3. 43 119298 Nom-001241 Hs. 155478 cyclinT2 3. 43 126486 A1065133 Hs. 152316 hypothetical protein PR00971 3. 43 130021 M24470 Hs. 1435 guanosine monophosphate reductase 3. 43 127166 AW954605 Hs. 263395 sema domain, transmembrane domain (TM), 3. 42 114988 AA251089 gb : 2s04f05. s1 NCI_CGAP_GCB1 Homo sapiens 3. 42 133817 AW578716 Hs. 7644 Hl histone family, member 2 3. 41 133562 M60721 Hs. 74870 H2. 0 (Drosophila)-like homeo box 1 3. 41 105610 AA280072 Hs. 99872 fetal Alzheimer antigen 3. 41 129007 AK001521 Hs. 107882 hypothetical protein FLJ10659 3. 41 100662 At368680 Hs. 816 SRY (sex determining region Y)-box 2 3. 41 120159 R60781 Hs. 92927 putative 47 kDa protein 3. 41 134966 AW402389 Hs. 920 modulator recogni6On fætor) 3. 41 100369 D79988 Hs. 115778 KlM0166geneproduct 3. 41 104260 AF008192 Hs. 194283 putative GR6 protein 3. 40 100134 AA305746 Hs. 49 macrophage scavenger receptor 1 3. 40 116015 AA338648 Hs. 50334 testes development-related NYD-SP22 3. 40 119251 T15753 Hs. 65250 EST 3. 40 127176 BE387162 Hs. 280858 ESTs, Highly similar to A35661 D excis 3. 40 123422 AA598484 gb : ae38fO4. s1Gessler Wilms tumor Homo s 3. 39 123094 AA761073 Hs. 146847 TRAFfamilymember-associatedNFKBæ6v 3. 39 105289 AB020638 Hs. 103000 KIAA0831 protein 3. 39 111219 N68836 Hs. 19247 ESTs, ModeratetysimitartoALUC_HUMAN ! 3. 38 127963 Api299013 Hs. 87779 Homo sapiens cD : FLJ23087 fis, clone L 3. 38 109412 BE543313 Hs. 209473 hypothetical protein FLJ10520 3. 38 118794 AW517051 Hs. 118210 ESTs 3. 38 112040 R43286 gb : yg17e11. s1 Scares infant brain INIB H 3. 38 111180 A1798851 Hs. 283108 hemoglobin, gamma G 3. 38 117329 AA524065 Hs. 93670 Homo sapiens cD : FU22664 fis, clone H 3. 38 104371 A1288696 Hs. 194081 ESTs, Weakly similar to 138022 hypothe6 3. 38 109265 AA195285 Hs. 85982 ESTs 3. 38 109557 AW452405 Hs. 6427 ESTs 3. 38 120753 AA312551 Hs. 230157 ESTs 3. 38 120970 AA398118 Hs. 97579 ESTs, Weakly similar to A46010 X-linked 3. 38 127094 F13215 Hs. 287849 ESTs, Weakly similar to T22074 hypothe6 3. 38 127746 At239495 Hs. 120189 ESTs 3. 38 123553 A) 494291 Hs. 111977 ESTs 3. 37 130652 M31669 Hs. 1735 inhibin, beta B (ac6vin AB beta polypep 3. 37 135101 U82275 Hs. 94498 leukocyte immunoglobulin-like receptor, 3. 37 121799 At885670 Hs. 124027 SELENOPHOSPHATE SYNTHETASE ; Human selen 3. 37 112278 Z41698 Hs. 26039 Homo sapiens cD FLJ13937 fis, clone Y7 3. 36

113401 AA610175 Hs. 179647 HomosapienscDFL ; i12195fis, ctoneMA 3. 36 109292 AW975746 Hs. 188662 KIAA1702 protein 3. 36 135026 N92165 Hs. 93231 ESTs 3. 36 118210 N49233 Hs. 46914 ESTs, Weakly similar to A46010 X-linked 3. 35 123476 AA384564 Hs. 108829 ESTs 3. 35 111076 N59129 Hs. 20851 ESTs 3. 35 111520 A1985369 Hs. 301134 ESTs 3. 35 133383 BE313555 Hs. 7252 KIAA1224 protein 3. 35 103731 AA070545 gb : zm70cO3. ri Stratagene neuroepithelium 3. 35 110828 AK002114 Hs. 23495 hypotheGcalprotein FLJ11252 3. 35 112520 R68654 Hs. 30814 ESTs 3. 35 115725 AW899053 Hs. 76917 F-box only protein 8 3. 35 125867 H13331 Hs. 123721 ESTs 3. 35 127719 Api242163 Hs. 22670 chromodomain helicase D binding protei 3. 35 129863 BE379765 Hs. 129872 sperm associated antigen 9 3. 35 130816 M61877 Hs. 1985 spectin, alpha, erythrocytic I (ellipto 3. 35 130888 AL044315 Hs. 173094 Homo sapiens mR for KIAA1750 protein, 3. 35 133377 AJ131245 Hs. 7239 SEC24 (S. cerevisiae) related gene fami) 3. 35 118986 AF148713 Hs. 125830 bladdercanceroverexpressed protein 3. 35 101723 U34304 gb : Human nonmuscle myosin heavy chain 11 3. 34 134693 N70361 Hs. 8854 Human transcription unit PVT gene, exons 3. 34 102856 M26150 Hs. 248177 H3 histone family, member L 3. 34 105593 AA279341 Hs. 174151 aldehyde oxidase 1 3. 34 134748 L34059 Hs. 89484 cadherin 4, type 1, R-cadherin (re6 !) 3. 34 109149 AA831179 Hs. 40065 hypothe6calprotein MGC4825 3. 33 115026 AA251972 Vs. 188718 ESTs 3. 33 103546 Z14244 Hs. 75752 cytochromecoxidasesubunitVltb 3, 33 111189 N67603 Hs. 272130 ESTs, Weakly similar to S65824 reverse t 3. 33 127076 A1422951 Hs. 146162 ESTs 3. 33 124949 AI903210 Hs. 336780 tubulin, beta polypeptide 3. 33 111012 A1077389 Hs. 269818 ESTs, Weakly similar to Z195_HUMAN ZINC 3. 33 113412 AW628660 Hs. 44131 KIAA0974 protein 3. 33 116351 AL133623 Hs. 82501 similartomouseXm1/Dhm2protein 3. 33 121633 AA417011 Hs. 98175 EST 3. 33 124591 N69243 Hs. 192974 hypothetical protein FLJ12735 3. 33 130225 AB021179 Hs. 15299 HMBA-inducible 3. 33 131945 NM002916 Hs. 35120 replication factor C (activator 1) 4 (37 3. 33 132581 AK000631 Hs. 52256 hypothetical protein FLJ20624 3. 33 105726 NM_012068 Hs. 9754 activating transcription factor 5 3. 32 101867 M96132 gb : Human MHCclass It HLA-DR-beta-1tû901 3. 32 105004 BE616023 Hs. 25298 KIAA1813 protein 3. 32 100288 AL039103 Hs. 153834 pumilio (Drosophila) homolog 1 3. 32 118349 N63786 Hs. 94149 ESTs, Weak. ysimitartoALU1 HUMANALUS 3. 32 103352 H09366 Hs. 78853 uracil-D glycosylase 3. 30 107436 W27720 Hs. 12450 protocadherin 9 3. 30 109062 AA160941 gb : zq40d12. s1 Stratagene hNT neuron (937 3. 30 110379 A1300505 Hs. 33130 Homo sapiens cD : FLJ23486 fis, clone t 3. 30 111221 AB037782 Hs. 15119 KIAA1361 protein 3. 30 117903 AA768283 Hs. 47111 ESTs 3. 30 123265 AA491209 gb : aa47aO8. s1 NCI_CGAP_GCB1 Homosapiens 3. 30 128226 Api284940 Hs. 289082 GM2 ganglioside activator protein 3. 30 111945 R40663 Hs. 124944 ESTs 3. 30 126214 AW748336 Hs. 168052 KIAA0421 protein 3. 30 121073 H46199 Hs. 112184 DKFZP586J0619 protein 3. 30 102083 T35901 Hs. 75117 interleukin enhancer binding factor 2, 4 3. 30 100992 NM007289 Hs. 1298 membrane metaiio-endopeptidase (neutral 3. 30 134021 L13720 Hs. 78501 growth arrest-specific 6 3. 30 126452 R26867. gb : yh52eO1. s1 Soares placenta Nb2HP Homo 3. 29 117195 At798425 Hs. 42710 ESTs 3. 29 127663 AK000452 Hs. 10340 hypothetical protein FLJ20445 3. 29 113677 Z70200 Hs. 246112 KtM0788protein 3. 28 132398 AA876616 Hs. 16979 ESTs, Weak ! ysimDartoA43932mucin2p 3. 28 109533 AL043979 Hs. 259729 KIAA0596 protein 3. 28 102915 X07820 Hs. 2258 matrix oproteise10 (stromefysin 3. 28 104348 H05405 Hs. 19221 hypothetical protein DKFZp566G1424 3. 28 113047 A1571940 Hs. 7549 ESTs 3. 28 113203 AA743563 Hs. 10305 ESTs 3. 28 114503 AL040600 Hs. 188083 ESTs 3. 28 122100 AA431220 Hs. 41086 plækstrinhomoBogydomain-containing, f 3. 28 123073 AA485061 Hs. 105652 ESTs 3. 28 130253 A1078570 Hs. 167473 phosphoglucomutase 5 3. 28 130365 W56119 Hs. 155103 eukaryotic translation initiation factor 3. 28 130762 D84371 Hs. 1898 paraoxose 1 3. 28 132360 AW893660 Hs. 46440 solute carrier family 21 (organic anion 3. 28 110763 AI929445 Hs. 92254 syptotagmin-like ike2 3. 27 103437 AV655598 Hs. 184211 peptidase (mitochondna) processing) bet 3. 27 114840 AA447591 Hs. 87359 ESTs, HighEysimilartoRB18_HUMANRAS-R 3. 27 106888 AA020964 Hs. 24734 oxysterol binding protein 3. 27 129896 BE295568 Hs. 13225 UDP-Ga ! : betaGjcc beta 1, 4-galætosy. t 3. 26 113459 T80206 Hs. 14716 ESTs 3. 26 134332 D86962 Hs. 81875 growth factor receptor-bound protein 10 3. 26 117048 H89732 Hs. 230113 EST 3. 26 109249 AA194730 Hs. 268189 hypothetical protein FLJ20436 3. 26

134663 W73428 Hs. 8750 uncharactedzed bone marrow protein BM04 3. 26 114440 AL046511 Hs. 106525 hypothetical protein FLJ12567 3. 25 102196 BE266830 Hs. 75238 chromatin assembly factor 1, subunit B 3. 25 109581 R45584 Hs. 23025 ESTs, Weakly similar to ALUS HUMAN ALU S 3. 25 120814 AW867796 Hs. 96860 ESTs, Weakly similar to 138022 hypotheti 3. 25 122391 M446316 Hs. 191622 ESTs 3. 25 122553 AA451884 Hs. 190121 ESTs 3. 25 124755 R38087 Hs. 267690 KIAA1228 protein 3. 25 130943 U20760 Hs. 272429 calcium-sensing receptor (hypocalciudc 3. 25 115185 BE299677 Hs. 105461 hypothetical protein FLJ20357 3. 25 114297 AA149707 Hs. 173091 ubiqui6n-like 3 3. 25 106657 AW854339 Hs. 33476 hypothetical protein FLJ11937 3. 25 124320 H95749 Hs. 102342 EST 3. 25 124087 H08773 Hs. 288590 Homo sapiens cD FLJ11454 fis, clone HE 3. 24 110705 AB007902 Hs. 32168 KIAA0442 protein 3. 24 106508 A1205785 Hs. 30348 ESTs 3. 24 112538 AA908813 gb : og77hO6. s1 NCI CGAP_Ov8 Homo sapiens 3. 24 100130 NM000304 Hs. 103724 peripheral myelin protein 22 3. 24 106017 AA477956 Hs. 26268 ESTs 3. 24 113921 AW976530 Hs. 28355 hypotheticai protein FLJ22402 3. 23 121520 AA412163 Hs. 164785 ESTs 3. 23 129255 Api961727 Hs. 109804 H1 histone famiiy, member X 3. 23 125069 H81306 Hs. 194485 ESTs 3. 23 119863 AA081218 Hs. 58608 Homo sapiens cD FLJ14206 fis, clone NT 3. 23 111273 N70934 gb : za33fO6. s1 Soares fetal liver spleen 3. 23 102971 X16609 Hs. 183805 ankyrin 1, erythrocytic 3. 23 103937 AA934063 Hs. 13836 ESTs, Weakly similar to 138022 hypothe6 3. 23 121770 NU15902 Hs. 278428 progestin induced protein 3. 23 128972 AA528140 Hs. 107515 ESTs, Weakly similar to T00329 hypotheti 3. 23 132528 T78736 Hs. 50758 SMC4 (structural maintence of chromoso 3. 23 134835 L04569 Hs. 89925 calcium channel, voltage-dependent, L ty 3. 23 103158 BE242587 Hs. 118651 hematopoletically expressed homeobox 3. 22 118405 AL117518 Hs. 3686 KIAA0978 protein 3. 22 104631 AA002064 Hs. 18920 ESTs 3. 22 114253 BE149866 Hs. 14831 Homo sapiens, Similar to zinc finger pro 3. 22 134607 A1675881 Hs. 86538 ESTs 3. 22 135114 AW340493 Hs. 175043 ancient conserved domain protein 4 3. 22 120191 BE407106 Hs. 65907 Homo sapiens, clone IMAGE : 3959816, mR, 3. 22 105029 Al122691 Hs. 13268 ESTs 3. 21 128550 AA418276 Hs. 170142 ESTs 3. 21 119873 A1660149 Hs. 44865 lysosomal 3. 21 130115 T47294 Hs. 149923 X-box binding protein 1 3. 21 133916 AL039185 Hs. 77558 thyroid hormone receptor interactor 7 3. 21 120259 AW014786 Hs. 192742 hypothetical protein FLJ12785 3. 21 110721 H97678 Hs. 31319 ESTs 3. 21 130062 AL049415 Hs. 278679 a disintegrin and metalloproteise doma 3. 21 100265 D38521 Hs. 112396 KIAA0077 protein 3. 20 100624 AB001025 Hs. 9349 ryanodine receptor 3 3. 20 122275 AA437124 Hs. 187247 ESTs 3. 20 127099 AA347668 gb : EST54026 Fetal heart tl Homo sapiens 3. 20 134321 BE538082 Hs. 8172 ESTs, Moderately similar to A46010 X-lin 3. 20 132809 AF036144 Hs. 5734 meningioma expressed anrigen 5 (hyaluron 3. 20 101125 AJ250562 Hs. 82749 transmembrane 4 superfamily member 2 3. 20 128339 AL121087 Hs. 296406 KIAA0685 gene product 3. 19 117121 H95044 Hs. 321386 EST 3. 19 124760 AW408586 Hs. 91052 ESTs, Moderately similar to ALU5_HUMAN A 3. 19 132232 A1522273 Hs. 42640 ESTs 3. 19 125919 W26713 Hs. 256972 ESTs 3. 19 123324 AB018352 Hs. 105399 KIAA0809 protein 3. 19 100157 D14661 Hs. 119 Wilms'tumourl-associatingprotein 3. 19 101447 M21305 gb : Human alpha satellite and satellite 3 3. 19 124345 NM014487 Hs. 120766 nucleolarcysteine-rich protein 3. 18 122583 NM 012447 Hs. 20132 stromal antigen 3 3. 18 128961 AL133014 Hs. 107387 CGI-20 protein 3. 18 111321 A1569766 Hs. 13205 ESTs 3. 18 134977 AL044963 Hs. 306121 leukocyte receptorcluster (LRC) encoded 3. 18 131535 N22120 Hs. 75277 hypothetical protein FLJ13910 3. 18 109950 H08200 Hs. 268770 ESTs, Weakly similar to 2004399A chromos 3. 18 129875 AA181018 Hs. 13056 hypothe6cal protein FU13920 3. 18 101654 M60298 Hs. 733 erythrocyte membrane protein band 4. 2 3. 18 104732 AL079294 Hs. 29952 Homo sapiens mR full length insert cDN 3. 18 106867 AB037744 Hs. 34892 KIAA1323 protein 3. 18 108301 AA069728 Hs. 184582 ribosomat protein L24 3. 18 118042 A1432389 Hs. 161465 ESTs 3. 18 120900 AA830712 Hs. 291931 ESTs 3. 18 129312 T97579 Hs. 110334 ESTs, Weakly similar to 178885 serine/th 3. 18 116291 AW410377 Hs. 41502 hypothe6caiproteinFW21276 3. 17 110672 AW612890 Hs. 191178 ESTs 3. 17 115665 BE072425 Hs. 44579 hypothetical protein FLJ20199 3. 17 127581 AK000680 Hs. 266175 phosphoprotein associated with GEMs 3. 17 129584 AV656017 Hs. 184325 CGI-76 protein 3. 16 108830 AA131743 Hs. 193352 ESTs 3. 16 124443 A1857519 Hs. 302031 zinc finger protein, subfamily 1A, 4 (Eo 3. 16

106290 AW961393 Hs. 16364 hypothetical protein FLJ10955 3. 16 122787 A1209093 Hs. 99512 ESTs 3. 16 133112 T15465 Hs. 182231 thyrotropin-releasing hormone 3. 16 116435 AA186761 Hs. 334812 hypothetical protein DKFZp586K0717 3. 16 109121 BE389387 Hs. 49767 DHdehydrogese (ubiquinone) Fe-Spro 3. 16 126721 AW579621 Hs. 125359 Thy-1 cell surface antigen 3. 15 102526 AA203429 Hs. 79474 tyrosine3-monooxygese/tryptophan5-mo 3. 15 100512 D13317 Hs. 78915 GA-bindingproteintranscrip6Onfector, 3. 15 105299 AF098951 Hs. 194720 ATP-binding cassette, sub-family G (WHIT 3. 15 117842 A1984505 Hs. 161121 ESTs 3. 15 123049 BE047680 Hs. 211869 dickkopf (Xenopus laevis) homo) 2 3. 15 128639 AW582962 Hs. 102897 CGI-47 protein 3. 15 130343 AB040914 Hs. 278628 KIAA1481 protein 3. 15 115706 AB004849 Hs. 50748 chromosome 21 open reading frame 18 3. 15 120673 AW968634 Hs. 105093 ESTs 3. 15 132116 AW960474 Hs. 40289 ESTs 3. 15 116217 AU076474 Hs. 123178 transtocaseofinnermitochondriatmembr 3. 15 104926 BE298808 Hs. 33363 DKFZP434N093 protein 3. 14 105297 NM 015905 Hs. 183858 transcriptio) intermediary factor 1 3. 14 125343 At475495 Hs. 304101 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 14 115618 H11695 Hs. 322901 disrupter of silencing 10 3. 14 124893 AA830185 Hs. 269680 ESTs 3. 13 105461 BE539071 Hs. 69388 hypothetical protein FLJ20505 3. 13 126165 A1741816 Hs. 125897 ESTs 3. 13 105212 AA205334 Hs. 324278 Homo sapiens mR ; cD DKFZp566M063 (fr 3. 13 101628 M57506 Hs. 72918 small inducible cytokine A1 (I-309, homo 3. 13 107951 A1300077 Hs. 61590 ESTs 3. 13 109166 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 3. 13 117299 N75768 gb : yw30bO7. r1 Modon Fetal Cochlea Homo 3. 13 119694 AA041350 Hs. 57847 ESTs, Moderately similar to ICE4_HUMAN C 3. 13 124840 R56146 Hs. 164515 EST, Weakly similar to AF0909301 PR0047 3. 13 127433 AW979155 Hs. 298275 amino acid transporter 2 3. 13 128337 A1123529 Hs. 166592 ESTs 3. 13 134053 AW628686 Hs. 78851 KIAA0217 protein 3. 13 134475 NM014733 Hs. 83790 KIAA0305 gene product 3. 13 128761 BE300341 Hs. 104925 ectodermal-neural cortex (with BTB-like 3. 12 124971 T23800 Hs. 151001 hypothetical protein FLJ14728 3. 12 128314 T87479 Hs. 291797 ESTs 3. 12 134695 AB036829 Hs. 178347 SKIP for skeletal muscle and kidney enri 3. 12 131333 BE244603 Hs. 25726 transposon-derived Busterl transposase-I 3. 12 119781 AJ278016 Hs. 55565 ankyrin repeat domain 3 3. 12 131824 U28838 Hs. 32935 TATA box binding protein (TBP)-associate 3. 11 124595 AW194851 Hs. 111801 arseteresistanceproteinARS2 3. 11 116115 AL042355 Hs. 70202 WD repeat domain 10 3. 11 129415 AI907084 Hs. 111243 MADS box transcrip6on enhancer factor 2 3. 11 111552 T97939 Hs. 191185 ESTs 3. 10 134861 Nt. 000937 Hs. 171880 polymerase (R) 11 (D directed) polyp 3. 10 104971 BE311926 Hs. 15830 hypothetical protein FLJ12691 3. 10 126536 AA156151 gb : zo48cO6. rl Stratagene endothelial cel 3. 10 128246 A1990612 Hs. 214818 DMRT-like family C2 3. 10 106412 AA453734 Hs. 10198 ESTs 3. 10 107902 AA026627 Hs. 61358 ESTs 3. 10 112495 A1346487 Hs. 28739 ESTs 3. 09 131870 NM014874 Hs. 3363 KIAA0214 gene product 3. 09 105301 AW352357 Hs. 7457 MAGE1 protein 3. 09 123670 A1189844 Hs. 112708 ESTs, ModeratelysimilartoZN91_HUMANZ 3. 09 116474 AW160774 Hs. 159154 tubulin, beta, 4 3. 09 112064 AL049390 Hs. 22689 Homo sapiens mR ; cDDKFZp58601318 (f 3. 09 130525 AA361850 Hs. 322149 Human clone 137308 mR, partial cds 3. 08 120398 AL133649 Hs. 110953 retinoic acid induced 1 3. 08 102735 AF111106 Hs. 3382 protein phosphatase 4, regulatory subuni 3. 08 124748 R34617 gb : yh85h12. s1 Soares placenta Nb2HP Homo 3. 08 120755 AA312934 Hs. 190745 Homo sapiens cD : FLJ21326 fis, clone C 3. 08 118895 BE304917 Hs. 31097 hypothetical protein FLJ21478 3. 08 107463 AW952022 Hs. 315164 hypothetical protein similar to ac6n re 3. 08 114290 R51383 Hs. 25793 ESTs 3. 08 119005 AL038511 Hs. 125316 ESTs, Weakly similar to S33990 finger pr 3. 08 125676 BE612918 Hs. 151973 hypothetical protein FLJ23511 3. 08 127766 AA723659 Hs. 290607 EST 3. 08 132693 BE244200 Hs. 55075 KIAA0410 gene product 3. 07 106812 BE251590 Hs. 239370 DKFZP7271051 protein 3. 07 125654 X96753 Hs. 9004 chondroifin sulfate proteoglycan 4 (mela 3. 07 111836 R58394 Hs. 25119 ESTs, Weakly similar to YEXO_YEAST HYPOT 3. 06 101682 AF043045 Hs. 81008 fitaminB, beta (æün-bindingprotein-2 3. 06 110004 H10413 Hs. 268774 ESTs 3. 06 117591 N64777 Hs. 44656 ESTs 3. 06 110737 AA335609 Hs. 7589 ESTs, Weakly similar to A46010 X-linked 3. 06 134337 Nu-004922 Hs. 81964 SEC24 (S. cerevisiae) related gene famil 3. 06 132450 AA100012 Hs. 48827 hypothetical protein FLJ12085 3. 06 125556 AB033064 Hs. 334806 KIAA1238 protein 3. 06 101811 Nom-002556 Hs. 24734 oxysterot binding protein 3. 06 131530 AA574309 Hs. 283402 TCReta 3. 06 105049 AB032945 Hs. 172506 myosinVB 3. 06

126614 AA701941 Hs. 187555 ESTs 3. 05 130960 AF035621 Hs. 21611 kinesin family member 3C 3. 05 105503 AW963624 Hs. 31707 ESTs, Weakly similar to YEW4YEASTHYPOT 3. 05 107361 U72513 Hs. 159486 Human RPL13-2 pseudogene mR, complete 3. 05 107575 D81886 Hs. 59908 ESTs 3. 05 116999 H84644 Hs. 40707 EST 3. 05 119554 W38188 (NONE) 3. 05 120934 AA226198 gb : nc26a07. s1 NCl_CGAF_Pr1 Homosapiens 3. 05 125805 Api160594 Hs. 166656 ESTs, Highly similarto S49460 glutamate 3. 05 127263 AA331156 gb : EST35034 Embryo, 6 week, subtracted 3. 05 128025 T64877 Hs. 108479 ESTs 3. 05 131090 A1143139 Hs. 2288 visinin-like 1 3. 05 112197 NM003655 Hs. 5637 ESTs 3. 05 133492 L40397 Hs. 74137 transmembrane trafficking protein 3. 04 118485 AA508515 Hs. 291049 ESTs 3. 04 113893 At373741 Hs. 59384 hypothetical protein MGC3047 3. 04 116911 AW205577 Hs. 308435 ESTs, Moderately similar to KIAA0745 pro 3. 04 132833 U78525 Hs. 57783 eukaryotictranslationinitiationfactor 3. 04 124724 H20816 Hs. 112423 Homo sapiens mR ; cD DKFZp58611420 (f 3. 04 105894 A1904740 Hs. 25691 receptor (calcitonin) activity modifying 3. 04 129991 R28386 Hs. 179925 ESTs, Weak ! ysimilartoALU8 HUMANALUS 3. 04 128714 T85231 Hs. 179661 tubulin, beta 5 3. 04 134650 U76376 Hs. 87247 harakih, BCL2-interacting protein (cont 3. 04 106851 A1458623 gb : tk04g09. x1 NCI_CGAP_Lu24 Homo sapiens 3. 04 133445 AC005262 Hs. 73797 guanine nucleo6de binding protein (G pr 3. 04 102581 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homotog 2 3. 04 127542 AA703684 Hs. 245474 ESTs, Moderately similar to ALU5HUMAN A 3. 03 113043 A1628789 Hs. 7483 ESTs 3. 03 134710 A1433797 Hs. 8889 se6ne hydroxymethyltransferase 1 (solub 3. 03 119245 Api815733 Hs. 114360 transforming growth factor beta-stimulat 3. 03 106391 AW959538 Hs. 321214 hypothetical protein DKFZp564D0478 3. 03 114607 AF041260 Hs. 129057 breast carcinoma amplified sequence 1 3. 03 116083 AA455706 Hs. 44581 heat shock protein hsp70-related protein 3. 03 132079 A1701457 Hs. 38694 ESTs 3. 03 103825 A1571835 Hs. 55468 ESTs 3. 03 106438 A1141031 Hs. 21342 ESTs 3. 03 124359 N22508 Hs. 139315 Homo sapiens cD : FLJ21479 fis, clone C 3. 03 126384 AW090198 Hs. 4779 KIAA1150 protein 3. 03 127995 AA970953 Hs. 128709 ESTs 3. 03 127981 AA837029 Hs. 157463 ESTs 3. 02 124417 N34059 gb : yv28hO9. s1 Soaresfetatliverspleen 3. 02 124357 N22401 gb : yw37g07. s1MortonFeta ! CochteaHomo 3. 02 105437 AF151076 Hs. 25199 hypothetical protein 3. 02 101158 AW327723 Hs. 76122 splicingfactor, arginine/serine-rich4 3. 02 113897 R91601 Hs. 4947 hypothetical protein FU22584 3. 02 100159 AA285268 Hs. 23488 KIAA0107 gene product 3. 02 106487 A1697340 Hs. 135265 Homo sapiens clone FLB8436 PR02277 mR, 3. 02 124977 F04819 Hs. 190452 KIAA0365 gene product 3. 02 131631 AA022569 Hs. 29802 slit (Drosophila) homolog 2 3. 01 102259 AL041219 Hs. 82222 semadomain, immunoglobu. indomain (lg), 3. 01 104399 AL022316 Hs. 301947 kraken-like 3. 01 116536 BE218027 Hs. 89969 ESTs 3. 00 125889 AA351978 Hs. 4943 hepatocellular carcinoma associated prot 3. 00 102233 AW163045 Hs. 79334 nuclear factor, interleukin 3 regulated 3. 00 102628 U90322 Hs. 27812 G protein-coupled receptor 23 3. 00 112812 H55977 Hs. 35810 ESTs 3. 00 114654 AA101840 Hs. 103679 ESTs 3. 00 118555 N68372 gb : za68c10. s1 Soares_fetåjung_NbHL19W 3. 00 120005 W90105 Hs. 94942 EST 3. 00 123596 AA421130 Hs. 112640 EST 3. 00 126134 AL133033 Hs. 4084 KIAA1025 protein 3. 00 126194 H98755 Hs. 302975 ESTs, Weakly similar to Z195 HUMANZINC 3. 00 129778 AK001676 Hs. 12457 hypothetical protein FLJ10814 3. 00 Table 38 : Pkey : Unique Eos probeset iden6fier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 123619 3716811 AA602964AA609200 124417 1642364_1 N34059 N46979 117299 1632586_1 N75768 N22543 116845 3934811 AA649530AA659316H64973 124748 1715080-1 R34617 125596 1708455 1 R25698 R56582 R56018 126257 182217 1 N99638 AW973750 AA328271 H90994AA558020AA234435 N59599 R94815 126280 1572221 1 Z19417 H20866 126319 1528523_1 D81689 D81802 104172 273499 1 AA476418 AA393338 AA398747 AA476518 126426 110687 1 AA125984AA127189AA065075AA070377AA100017AA079891 AA113255AA075168AA082764AA083380 N84829AA084752 AA076512 AA085119 AA085208 AA085045 126433 127143_1 AA325606 AA099517 N89423

127092 1779998 1 T26985Z44165 127099 244301_1 M347668AW956810Z44271 F07065F07064R13506 126536 1492061 AA156151 Z25109 C05177 103731 112052_1 AA070545 AA13i490 AA131373 127263 2321611 AA331156AA331157AA331155 126783 113388J AA083531AA126047AA074915AA148649 118946 1683457 1 N92834W25061 127520 656170-1 T51239 127532 353907_1 AJ003429 AJ003367 AA564825 112516 1744223_1 T83909 R68586 112538 5045791 AA908813R70255 112540 1605263 1 R69751R70467H69771H80879H80878 113248 328626 1 T63857 AW971220 AA493469 T63699 112631 1746257 1 R82040 R70934 128360 1540098 1 F12374 T74059 120514 255323 AA258335AA258499 127867 1511945 1 C18530T63953 120637 200885 1 AA811804 AA809404 AA286907 AW977624 121481 123001_1 AA411931AA4H930 120934 1775211 AA226198AA226513AA383773 106566 120358_1 BE298210 Al672315 AW086489 BE298417 M455921 M902537 BE327124 R14963M085210 AW274273 A1333584 At369742 A1039658 A1885095 A1476470 A1287650 A1885299 A1985381 AW592624 AW340136 A1266556 AA456390 A1310815 AA484951 121743 2745821 AA397636AA421144 114699 135322_1 AA127386 R15644 AA127404 106851 322947 1 A1458623 AA639708 AA485409 R22065 AA485570 123731 genbankAA609839 AA609839 123973 506369-1 C14805 116793 74964_1 T77781 AW014157 D12422 AI918246 AA452599 AA62Bd04 N35886 AA464593 AW301738 T77780 A1042309 Al095302 H60603 AW510576 H37814 W61360 A) 373286 At702287 AA152465 AW169067 AW169012 AW340355 AI289311 109700 genbank_F09609 F09609 118466 genbank_N66741 N66741 111273 genbank_N70934 N70934 118555 genbank_N68372 N68372 111462 genbank R05296 R05296 118720 genbank N73515 N73515 118737 382979_1 AA199686 N73861 111826 genbank R35975 R35975 120376 genbankAA227469 AA227469 120809 genbankAA346495 AA346495 120839 genbankAA348913 AA348913 120873 genbank_M358015 AA358015 115498 genbankAA291070 AA291070 101045 entrezJ05614 J05614 129969 genbank N57818 N57818 108407 genbanCAA075519 AA075519 122939 genbankAA477141 AA477141 117031 genbank_H88353 H88353 124298 genbank H91679 H91679 117099 321871_1 H93699 H97976 H80036 101447 entrez_M21305 M21305 124357 genbank N22401 N22401 101723 2603_1 U34304 AA355800 M69181 M375523 AA093590 AA365595 S67247 AI371761 AW351920 AW181991 H28934 W79172 AA653543 AA122005 W95572 AF086505 C02448 W57668 T11988 W95465 AA425179 F05724 F12205 F06285 R16384 T66222 F08515 F07288 AA150346 H83264 T86770 N36366 AA337253 H12001 H82899 H69395 H69380 N29054 N30920 T97385 T96819 AA463807 AL079860 T11987 AA305048 AA149133 T82813 AA029555 AA035109 AA449123 AA340297 AA724155 W05196 A1859528 AA149134 C16426 C16097 C16587 C16138 C16107 AW021754 C16500 N30019 R55718 R60552 N84522 Art143322 AW519024 AA490700 N20675 AW296747 C16068 D58331 C16518 AI141214 N67221 C16423 C16537 C16094 C16152 H28935 T66152 C16362 AW022425 AA602899 AA694603 H22255 W74368 C16356 Al 129361 A1917986 At582253 A1923898 A1038907 AW191970 A1678861 C16429 C16345 A1277790 R42325 A1640420 A1004136 A1277797 C16100 F09836 T71212AA152316 AW090781 AtO55902T16084AW022915 C16556 AW473979 T96820 AA476595 N75446 F02570 H69286 T89992 AA907493 T34275 M156107 H11758 A. 650288 H82900 AI474575 N66718 F04914 AA505470 AA993349 F01973 All 23277 F04729 C16236 AA879148 AA029574 AA887046 R08127 D57339 AA490477 A1669818 A1190995 AA035507 AL119272 AL135029 AA258725 AL079521 N40299 A1630191 N86148 AA341165 T28492 N83749 A1382123 A1065033 A1950411 A1935653 A1275551 AW027482 AW 197337 AI168323 AI336930 A1094099 AI351490 AA258563 AI634763 AI492374 AA983970 AI123565 T72559 F09890 AA669531 AI445824 T07180 AW084799 AA306254 R60606 W28367 R55928 W27995 AL044845 AA501890 N84045 T97274 N97532 AL135219 AA116056 TO6000 AA116057 TW 181 R08126 124677 genbank R01073 R01073 110243 genbank H26683 H26683 101867 entrez M96132 M96132 101941 entrez_S77583 S77583 119052 149538_1 R10889 R10888 126452 209811_1 R26867 R27438 119263 genbank T15977 T15977 112040 genbank R43286 R43286 103657 entrez_s3677 D3677 119400 genbankT92767 T92767 119554 NOT_FOUND_entrez_W38188 W38188 123130 genbank_M487200 AA487200 123143 genbank AA487595 AA487595 121950 genbank_M429515 AA429515 123265 genbankAA491209 AA491209 114988 genbanItAA251089 AA251089 107794 genbankAA019255 AA019255

123422 genbankAA598484 AA598484 109062 genbankAA160941 AA160941 TABLE 4A : ABOUT 1164 GENES UPREGULATED IN GLIOBLASTOMA Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene TiUe : Unigene gene title R1 : Ratio of brain tumor to body atlas R2 : Ratio of brain tumor to normal brain Pkey ExAccn UnigeneiD Unigene Title R1 R2 412719 AW016610 Hs. 129911 ESTs 117. 6 3. 3 428321 A1699994 Hs. 301347 ESTs 108. 9 3. 9 455601 AI368680 Hs. 816 SRY (sex determining region Y)-box 2 107. 5 9. 9 431917 D16181 Hs. 2868 peripheral myelin protein 2 99. 0 11. 8 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 72. 0 11. 3 449494 AW237014 Hs. 286650 aquaporin 4 60. 0 2. 2 439285 AL133916 Hs. 298998 ESTs 58. 2 2. 2 447072 D61594 Hs. 17279 tyrosyiproteinsuifotransferasel 54. 2 7. 1 456759 BE259150 Hs. 127792 delta (Drosophilarlike 3 53. 5 2. 5 427343 Ai880044 Hs. 176977 protein kinase C binding protein 2 49. 6 2. 2 425088 M663372 Hs. 169395 Homo sapiens cDNA FLJ12015 fis, clone HE 49. 5 3. 1 412959 D87458 Hs. 75090 KIM0282 protein 46. 3 3. 0 447004 AW296968 Hs. 157539 ESTs 43. 7 3. 2 436878 BE465204 Hs. 47448 ESTs 39. 8 10. 8 433551 A ! 985544 Hs. 289048 ESTs 39. 7 4. 3 425842 Al587490 Hs. 159623 NK-2 (Drosophila) homolog B 39. 3 26. 2 407034 U84540 gb : HumandystrobrevinisoformDTN-3 (DTN 39. 1 39. 1 431725 X65724 Hs. 2839 Nome disease (pseudoglioma) 38. 4 3. 7 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 37. 5 22. 1 447197 R36075 gb : yh88bO1. s1 Scares placenta Nb2HP Homo 37. 5 13. 9 439415 F05538 Hs. 12825 ESTs 35. 4 3. 1 409395 U46745 Hs. 54435 dystrobrevin, alpha 34. 3 3. 0 449539 W80363 Hs. 58446 ESTs 33. 6 33. 6 408562 AI436323 Hs. 31141 Homo sapiens mRNA for KIAA1568 protein, 32. 8 5. 9 431019 NM_005249 Hs. 2714 forkhead box GIB 32. 4 17. 0 427540 R12014 Hs. 20976 ESTs 32. 1 2. 0 425057 AA826434 Hs. 96944 ESTs 31. 0 2. 3 431941 AK000106 Hs. 272227 Homo sapiens cDNA FLJ20099 fis, clone CO 30. 8 30. 8 416829 AB013805 Hs. 80220 catenin (cadherin-associated protein), d 30. 4 2. 2 420807 AA280627 Hs. 57846 ESTs 30. 4 30. 4 444190 At878918 Hs. 10526 cysteine and glycine-rich protein 2 30. 4 30. 4 429466 M85835 Hs. 12827 ESTs 30. 2 7. 2 444471 AB020684 Hs. 11217 KIAA0877 protein 29. 5 29. 5 451678 AA374181 Hs. 26799 DKFZP564D0764 protein 28. 8 3. 0 439979 AW600291 Hs. 6823 hypotheticai protein FLJ10430 27. 7 3. 2 433800 A1034361 Hs. 135150 lung type-I cell membrane-associated gly 27. 1 27. 1 440435 AL042201 Hs. 21273 ESTs 26. 9 26. 9 411078 AI222020 Hs. 182364 ESTs, Weakly similar to 25 kDa trypsin i 26. 0 26. 0 407808 AA663559 Hs. 289109 dimethylarginine dimethylaminohydrolase 25. 8 2. 2 416155 A1807264 Hs. 205442 ESTs, Weakly similar to AF1176101 inner 25. 5 25. 5 421659 NM 014459 Hs. 106511 protocadherin 17 25. 0 3. 3 430132 AA204686 Hs. 234149 hypothetical protein FLJ20647 24. 7 24. 7 433332 A1367347 Hs. 127809 ESTs 24. 6 24. 6 452744 A1267652 Hs. 30504 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 23. 8 23. 8 419271 N34901 Hs. 238532 ESTs 23. 6 5. 5 447397 BE247676 Hs. 18442 E-1 enzyme 23. 1 3. 2 439039 Al656707 Hs. 48713 ESTs 23. 0 7. 2 414175 A) 308876 Hs. 103849 ESTs 22. 2 2. 0 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 22. 0 7. 6 410102 AW248508 Hs. 279727 Homo sapiens cDNA FLJ14035 fis, clone HE 21. 6 2. 3 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 21. 2 3. 0 451468 AW503398 Hs. 210047 ESTs 21. 0 4. 7 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 20. 8 20. 8 443850 AW014723 Hs. 134719 ESTs 20. 4 38. 5 418738 AW388633 Hs. 6682 ESTs 20. 2 2. 2 449433 A1672096 Hs. 9012 ESTs 19. 9 16. 6 435706 W31254 Hs. 7045 GL004 protein 19. 7 19. 7 407192 AA609200 gb : af12e02. s1SoarestestisNHT Homo sap 19. 7 19. 7 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 19. 6 19. 6 442562 BE379584 Hs. 34789 ESTs 19. 4 19. 4 439451 AF086270 Hs. 278554 heterochromatin-like protein 1 19. 1 17. 4 426320 W47595 Hs. 169300 transforming growth factor, beta 2 18. 7 5. 4 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) 18. 6 18. 6 452106 A1141031 Hs. 21342 ESTs 18. 6 10. 3 431173 AW971198 Hs. 294068 ESTs 18. 6 18. 6 422583 M410506 Hs. 118578 H. sapiensmRNAforribosomalproteinL18 18. 5 18. 5 419088 A1538323 Hs. 77496 small nuclear ribonucleoprotein polypept 18. 5 18. 5 443547 AW271273 Hs. 23767 Homo sapiens cDNA FLJ 12666 fis, cione NT 18. 5 5. 1 451592 A1805416 Hs. 213897 ESTs 18. 4 18. 4 450313 A1038989 Hs. 24809 hypothetical protein FLJ10826 18. 3 18. 3

422544 AB018259 Hs. 118140 KtM0716geneproduct 18. 2 4. 7 408096 BE250162 Hs. 83765 dihydrofotate reductase 18. 0 18. 0 418027 AB037807 Hs. 83293 hypothetical protein 18. 0 8. 2 414117 W88559 Hs. 1787 proteolipid protein (Pelizaeus-Merzbache 18. 0 18. 0 429418 A1381028 Hs. 99283 ESTs 17. 8 17. 8 432527 AW975028 Hs. 102754 ESTs 17. 7 4. 2 447809 AW207605 Hs. 164230 ESTs, Highlysimilartophosphodiesteras 17. 5 4. 3 419704 AA429104 Hs. 45057 ESTs 17. 4 4. 6 436476 AA326108 Hs. 53631 ESTs, Weakly similar to enhancer-of-spli 17. 4 2. 1 445133 AW157646 Hs. 153506 ESTs, Weakly similar to AF1507551 micro 17. 3 18. 8 446659 A1335361 Hs. 226376 ESTs 17. 2 2. 8 409049 A1423132 Hs. 146343 ESTs 17. 2 3. 8 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 17. 2 11. 0 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Circadian Oscillat 17. 0 6. 3 438527 A1969251 Hs. 143237 ESTs 16. 9 16. 9 417791 AW965339 Hs. 111471 ESTs 16. 8 10. 5 417355 D13168 Hs. 82002 endothelin receptor type B 16. 4 16. 4 427897 NM 017413 Hs. 181060 apelin ; peptide ligand for APJ receptor 16. 3 4. 2 419721 NM_001650 Hs. 288650 aquaporin 4 16. 2 4. 4 427701 AA411101 Hs. 221750 ESTs 16. 1 3. 9 432435 BE218886 Hs. 282070 ESTs 16. 1 5. 7 426809 BE313114 Hs. 29706 ESTs 16. 0 10. 0 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-0-sulfot 15. 9 15. 9 400859 15. 7 15. 7 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 15. 6 15. 6 420092 AA814043 Hs. 88045 ESTs 15. 6 5. 4 449605 AW138581 Hs. 198416 ESTs 15. 5 3. 0 422365 AF035537 Hs. 115521 REV3 (yeast homolog)-like, catalytic sub 15. 3 4. 6 449611 Al970394 Hs. 197075 ESTs 15. 2 15. 2 414922 D00723 Hs. 77631 glycine cleavage system protein H (amino 15. 2 5. 6 405238 15. 1 2. 8 429007 D80642 gb : HUM092E09BHumanfetalbrain (TFujiwa 15. 0 3. 5 409638 AW450420 Hs. 21335 ESTs 14. 9 7. 1 445888 AF070564 Hs. 13415 Homosapiensclone24571 mRNAsequence 14. 8 5. 7 416737 AF154335 Hs. 79691 LIM domain protein 14. 7 4. 2 429163 AA884766 gb : am20a10. s1 Soares_NFL_T_GBC_S1 Homos 14. 6 3. 0 436870 AW204219 Hs. 43679 ESTs 14. 6 2. 6 443181 A1039201 Hs. 54548 ESTs 14. 6 3. 5 436281 AW411194 Hs. 120051 ESTs 14. 5 8. 5 449448 D60730 Hs. 57471 ESTs 14. 4 4. 8 422564 A) 148006 Hs. 222120 ESTs 14. 4 14. 4 448243 AW369771 Hs. 77496 smal nuctear ribonucteoprotein polypept 14. 3 2. 4 428748 AW593206 Hs. 98785 ESTs 14. 2 14. 2 452576 AB023177 Hs. 29900 KIAA0960 protein 14. 1 8. 1 452461 N78223 Hs. 108106 transcription factor 14. 1 12. 8 449670 F07693 Hs. 23869 Homo sapiens mRNA ; cDNA DKFZp434K2172 (f 14. 1 14. 1 436637 A1783629 Hs. 26766 ESTs 14. 0 2. 3 429597 NM_003816 Hs. 2442 adisintegrinandmetaltoproteinasedoma 13. 9 13. 9 419078 M93119 Hs. 89584 insulinoma-associated 1 13. 9 2. 9 410889 X91662 Hs. 66744 twist (Drosophila) homolog (acrocephalos 13. 9 4. 1 452355 N54926 Hs. 29202 G protein-coupled receptor 34 13. 9 13. 9 421452 A1925946 Hs. 104530 fetal hypothetical protein 13. 9 13. 9 430290 A1734110 Hs. 136355 ESTs 13. 8 13. 8 430387 AW372884 Hs. 240770 nuclear cap binding protein subunit 2, 2 13. 6 13. 6 415875 AA894876 Hs. 5687 protein phosphatase 1B (formerly 2C), ma 13. 5 13. 5 416795 A1497778 Hs. 168053 ESTs, Highly similar to AF227948 1 HBV p 13. 5 13. 5 422025 BE348774 Hs. 122554 ESTs 13. 3 13. 3 400992 13. 3 5. 5 413174 AA723564 Hs. 191343 ESTs 13. 2 2. 5 425187 AW014486 Hs. 22509 ESTs 13. 1 8. 2 456965 AW131888 Hs. 172792 ESTs, Weakly similar to hypothetical pro 13. 1 2. 7 419852 AW503756 Hs. 286184 hypothetical protein dJ551D2. 5 13. 0 2. 4 409327 L41162 Hs. 53563 collagen, type IX, alpha 3 12. 9 4. 0 439519 AA837118 Hs. 118366 ESTs 12. 9 7. 6 436299 AK000767 Hs. 5111 hypothetical protein FLJ20729 12. 7 3. 1 446657 A1335191 Hs. 260702 ESTs, Moderately similar to ALU7 HUMAN A 12. 6 12. 6 423073 BE252922 Hs. 123119 MAD (mothers against decapentaplegic, Dr 12. 6 12. 6 424278 AK000723 Hs. 144517 hypothetical protein FLJ20716 12. 6 12. 6 451996 AW514021 Hs. 245510 ESTs 12. 6 7. 0 400860 12. 5 23. 1 439579 AF086400 gb : HomosapiensfulilengthinsertcDNA 12. 4 12. 4 408312 AF263613 Hs. 44198 intracellularmembrane-associatedcaiciu 12. 4 12. 4 419948 AB041035 Hs. 93847 NADPHoxidase4 12. 4 2. 4 427304 AA761526 Hs. 163853 ESTs 12. 3 12. 3 419498 AL036591 Hs. 20887 hypothetical protein FLJ10392 12. 2 12. 2 428137 AA421792 Hs. 170999 ESTs 12. 2 12. 2 432683 AW995441 Hs. 10475 ESTs 12. 2 2. 0 408622 AA056060 Hs. 202577 Homo sapiens cDNA FLJ 12166 fis, clone MA 12. 1 12. 1 453884 AA355925 Hs. 36232 KIAA0186 gene product 12. 0 5. 2 441440 A ! 807981 Hs. 30495 ESTs 12. 0 3. 6 414217 AI309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 12. 0 62. 7 410227 AB009284 Hs. 61152 exostoses (multiple)-like 2 11. 9 2. 9 439444 A1277652 Hs. 54578 ESTs 11. 9 16. 5

433309 AA807060 Hs. 126558 ESTs 11. 7 9. 0 439170 AA332365 Hs. 165539 ESTs 11. 6 9. 7 417160 N76497 Hs. 1787 proteofipid protein (Petizaeus-Merzbache 11. 5 7. 2 424668 D83702 Hs. 151573 cryptochrome 1 (photolyase-like) 11. 5 5. 8 410611 AW954134 Hs. 20924 KIAA1628 protein 11. 5 28. 2 437124 AA554458 Hs. 204200 ESTs 11. 5 11. 5 418858 AW961605 Hs. 21145 HomosapienscDNA : FLJ22489 fis, clone H 11. 3 11. 3 423600 A1633559 Hs. 29076 HomosapìenscDNA : FW218416s, ctoneH 11. 3 2. 8 429393 AA383024 Hs. 201603 ESTs, Highly similar to hypothetical pro 11. 3 11. 3 431103 M57399 Hs. 44 pleiotrophin (hepadn binding growth fac 11. 3 3. 4 452092 BE245374 Hs. 27842 hypotheGcalprotein FLJ11210 11. 3 11. 7 431701 AW935490 Hs. 14658 ESTs 11. 3 Z6 429399 AA452244 Hs. 16727 ESTs 11. 2 2. 2 408988 AL119844 Hs. 49476 HomosapiensctoneTUA8Cri-du-chatregi 11. 2 27. 8 442671 At005668 Hs. 134779 EST 11. 1 11. 1 402524 11. 1 11. 1 415558 AA885143 Hs. 125719 ESTs 11. 1 11. 1 422390 AW450893 Hs. 121830 ESTs, Weakly similar to KIAA0924 protein 11. 0 8. 8 418475 AI858732 Hs. 30443 sentrin/SUMO-specificprotease 11. 0 6. 1 458809 AW972512 Hs. 20985 sin3-associated polypepUde, 30kD 11. 0 5. 6 410297 AA148710 Hs. 159441 ESTs 11. 0 3. 3 444017 U04840 Hs. 214 neuro-oncological ventral antigen 1 11. 0 11. 0 437814 A1088192 Hs. 135474 ESTs, Weak ! ysimilartoDDX9_HUMANATP-D 10. 9 3. 3 427194 AA399018 Hs. 250835 ESTs 10. 8 8. 0 432060 AW971364 gb : EST383453 MAGE resequences, MAGL Homo 10. 8 10. 0 453861 A1026838 Hs. 30120 ESTs 10. 8 10. 8 408829 NM 006042 Hs. 48384 heparan sulfate (glucosamine) 3-0-sulfot 10. 6 3. 3 416913 AW934714 gb : RC1-DT0001-031299-011-a11 DT0001 Homo 10. 6 3. 4 418049 AA211467 Hs. 190488 hypotheticalprotein FlJ10120 10. 6 10. 6 413063 AL035737 Hs. 75184 chitinase 3-like 1 (carti) age giycoprote 10. 6 27. 2 425264 AA353953 Hs. 20369 ESTs, Weakly similar to gonadotropin ind 10. 5 2. 0 434408 A1031771 Hs. 132586 ESTs 10. 5 10. 5 451697 AW449774 Hs. 257208 ESTs 10. 5 6. 2 436754 A1061288 Hs. 133437 ESTs, Moderately similar to gonadotropin 10. 3 10. 3 410298 A ! 693821 Hs. 182185 ESTs 10. 3 2. 9 412766 BE544475 Hs. 54347 ESTs 10. 3 10. 3 450689 A) 369275 Hs. 243010 ESTs, Moderately similar to RTCO_HUMAN G 10. 3 10. 3 408331 NM_007240 Hs. 44229 dual specificity phosphatase 12 10. 3 4. 5 442007 AA301116 Hs. 142838 Homo sapiens cDNA : FLJ23444 fis, clone H 10. 3 10. 3 410386 W26187 Hs. 3327 HomosapienscDNAFLJ22219fis, cloneH 10. 2 2. 1 440684 A1253123 Hs. 127356 ESTs, Highly similar io NEST HUMAN NESTI 10. 1 10. 1 420892 AW975076 Hs. 172589 nuclear phosphoprotein similar to S. cer 10. 0 10. 0 419594 AA013051 Hs. 91417 topoisomerase (DNA) 11 binding protein 9. 9 15. 8 419972 AL041465 Hs. 294038 ESTs, Moderately similar to ALU2_HUMAN A 9. 7 23. 2 433730 AK002135 Hs. 3542 hypothetical protein FUI 1273 9. 6 6. 5 434851 AA806164 Hs. 116502 ESTs 9. 5 6. 5 436306 AA805939 Hs. 117927 ESTs 9. 5 4. 7 453331 A1240665 Hs. 8895 ESTs 9. 2 5. 8 414429 R51494 Hs. 71818 ESTs 9. 0 6. 2 424998 U58515 Hs. 154138 chitinase 3-like 2 8. 9 18. 1 446936 H10207 Hs. 47314 ESTs 8. 9 3. 6 410276 Ai554545 Hs. 68301 ESTs 8. 8 3. 8 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 8. 8 3. 8 448321 Nul005883 Hs. 20912 adenomatous polyposis coli like 8. 8 20 414783 AW069569 Hs. 75839 zinc finger protein 6 (CMPX1) 8. 7 3. 0 441079 AW150697 Hs. 107418 ESTs 8. 7 2. 2 437517 A1927675 Hs. 99858 dbosomal protein L7a 8. 6 4. 5 409062 AL157488 Hs. 50150 Homo sapiens mRNA ; cDNADKFZp564B182 (fr 8. 6 12. 2 420630 AL133101 Hs. 99508 HomosapiensmRNA ; cDNADKFZp43400921 (i 8. 6 10. 4 409260 AW242407 Hs. 18479 ESTs 8. 5 11. 6 442343 AA992480 Hs. 129874 ESTs 8. 4 4. 6 416439 AA180363 Hs. 118769 ESTs 8. 4 7. 2 428054 A1948688 Hs. 266619 ESTs 8. 2 9. 2 421633 AF121860 Hs. 106260 sorEng nexin 10 8. 2 2. 6 433285 AW975944 Hs. 237396 ESTs 8. 1 3. 3 433226 AW503733 Hs. 9414 KIAA1488 protein 8. 0 13. 4 424800 AL035588 Hs. 153203 MyoD family inhibitor 8. 0 2. 5 425681 AB018297 Hs. 159183 K) AA0754 protein 7. 9 4. 8 445034 AW293376 Hs. 160323 ESTs 7. 9 3. 7 435020 AW505076 Hs. 301855 DiGeorge syndrome critical region gene 8 7. 6 6. 4 446985 AL038704 Hs. 156827 ESTs, Weakly similar to ALU1_HUMAN ALU S 7. 5 7. 8 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteopontin, 7. 5 3. 9 418522 AA605038 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 7. 5 2. 2 439864 A1720078 Hs. 291997 ESTs 7. 4 6. 9 419723 AL120193 Hs. 92614 Homo sapiens growth differentiation fact 7. 4 3. 5 447896 At436124 Hs. 294069 ESTs, Weakly similar to ORF2 contains a 7. 3 22. 1 404210 7. 3 40. 8 436671 AW137159 Hs. 146151 ESTs 7. 2 11. 8 439231 AW581935 Hs. 141480 ESTs 7. 2 2. 5 418030 BE207573 Hs. 83321 neuromedin B 7. 1 6. 4 459290 Nom-001546 Hs. 34853 inhibitor of DNA binding 4, dominant neg 7. 0 6. 7 423869 BE409301 Hs. 134012 C1q-relatedfactor 7. 0 4. 9 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 6. 9 6. 4

420018 U56387 Hs. 94376 proprotein convertase subblisin/kexin t 6. 9 8. 6 428600 AW863261 Hs. 15036 ESTs, HighlysimilartoAF1613581HSPC0 6. 9 7. 7 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 6. 9 3. 1 402604 6. 8 7. 0 417022 NMJ) 14737 Hs. 80905 Ras association (RaIGDS/AF-6) domain fam 6. 8 2. 5 405239 U89281 Hs. 11958 oxidative 3 alpha hydroxysteroid dehydro 6. 8 2. 9 433577 AW007080 Hs. 8817 ESTs 6. 6 2. 6 434629 AA789081 Hs. 4029 glioma-amplified sequence-41 6. 6 13. 9 413886 AW958264 Hs. 103832 ESTs, WeaklysimilartoTRHY_HUMANTRIGH 6. 6 2. 2 451460 Api797550 Hs. 209652 ESTs 6. 5 13. 7 442145 A1022650 Hs. 8117 erbb2-interacting protein ERBIN 6. 5 15. 6 437273 AL137451 Hs. 120873 ESTs, Highly similar to hypothetical pro 6. 5 2. 4 418365 AW014345 Hs. 161690 ESTs 6. 4 12. 8 421684 BE281591 Hs. 106768 hypothetical protein FLJ10511 6. 4 4. 3 449458 A1805078 Hs. 208261 ESTs 6. 4 2. 3 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 6. 3 13. 2 426423 NM012446 Hs. 169833 single-stranded-DNA-binding protein 6. 3 10. 9 417709 D87434 Hs. 82426 KIAA0247 gene product 6. 3 23. 3 448499 BE613280 Hs. 250655 prothymosin, alpha (gene sequence 28) 6. 2 2. 9 444880 AW118683 Hs. 154150 ESTs 6. 2 19. 4 432715 AA247152 Hs. 200483 ESTs, WeaklysimitarloKtM1074pnotein 6. 2 12. 7 444864 AW965446 Hs. 46637 ESTs, Weakly similar to cDNA EST yk289g5 6. 2 4. 1 407792 Alto77715 Hs. 39384 putative secretedligand homoiogoustof 6. 2 3. 4 431962 AL049385 Hs. 272251 Homo sapiens mRNA ; cDNA DKFZp586M1418 (f 6. 1 2. 6 424232 AB015982 Hs. 143460 protein kinase C, nu 6. 1 14. 6 436443 AW138211 Hs. 128746 ESTs 6. 1 2. 8 433647 AA603367 Hs. 222294 ESTs 6. 1 15. 0 449961 AW265634 Hs. 133100 ESTs 6. 1 3. 4 448704 AW080932 Hs. 249247 heterogeneous nuclear protein similar to 6. 1 6. 1 408393 AW015318 Hs. 23165 ESTs 6. 1 21. 6 450693 AW450461 Hs. 203965 ESTs 6. 1 Z2 407846 AA426202 Hs. 40403 Cbp/p300-interacGng transactivator, wit 6. 0 2. 4 445817 NM_003642 Hs. 13340 histone acetyltransferase 1 6. 0 10. 9 440650 R44692 Hs. 6640 ESTs 6. 0 2. 1 417675 A1808607 Hs. 3781 similartomurineteucine-richrepeatpr 6. 0 2. 4 411083 N41340 Hs. 68318 hypothetical protein FLJ20344 6. 0 3. 6 407910 AA650274 Hs. 41296 fbronectin leucine rich transmembrane p 6. 0 6. 0 402855 6. 0 2. 6 445594 AW058463 Hs. 12940 zinc-fingers and homeoboxes 1 6. 0 11. 6 418791 AA935633 Hs. 194628 ESTs 5. 9 6. 7 409262 AK000631 Hs. 52256 hypothetical protein FLJ20624 5. 9 2. 3 435677 AA694142 Hs. 293726 ESTs 5. 9 11. 8 430334 At824719 Hs. 47557 ESTs 5. 9 7. 5 452834 Al638627 Hs. 105685 ESTs 5. 9 2. 6 427315 AA179949 Hs. 175563 Homo sapiens mRNA ; cDNA DKFZp564N0763 (f 5. 8 3. 1 428250 AW809208 Hs. 183297 DKFZP566F2124 protein 5. 8 2. 0 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 5. 8 2. 5 417115 AW952792 Hs. 1066 small nuclear ribonucleoprotein polypept 5. 8 16. 0 436758 AW977167 Hs. 155272 ESTs 5. 8 3. 8 446332 AK001635 Hs. 14838 hypothetical protein FLJ10773 5. 7 5. 1 423943 AF163570 Hs. 135756 polymerase (DNA-directed) kappa 5. 7 11. 1 428180 AH29767 Hs. 182874 HomosapienscDNA : FU21929 fis, clone H 5. 6 7. 1 424343 AW956360 Hs. 4748 ESTs, Highly similar to J N0902 pituitary 5. 6 2. 2 417318 AW953937 Hs. 12891 ESTs 5. 6 25. 0 423582 BE000831 Hs. 23837 Homo sapiens CDNA FU 11812 fis, clone HE 5. 6 4. 1 427472 AA522539 Hs. 131250 transposon-derivedBuster3transposase-1 5. 4 3. 5 434701 AA460479 Hs. 4096 KiAA0742 protein 5. 4 21. 2 430147 R60704 Hs. 234434 hairy/enhancer-of-split related with YRP 5. 3 2. 7 411019 AW993097 Hs. 48617 Homo sapiens CDNA FUI 2540 fis, clone NT 5. 3 4. 1 424939 AK000059 Hs. 153881 Homo sapiens NY-REN-62 antigen mRNA, par 5. 3 2. 4 424028 AF055084 Hs. 153692 KIAA0686 protein 5. 3 2. 7 444534 AW271626 Hs. 42294 ESTs 5. 3 2. 1 426171 A1128606 Hs. 301454 ESTs 5. 2 3. 8 431843 AA516420 Hs. 183526 ESTs 5. 2 6. 2 438204 A1589645 Hs. 128690 ESTs 5. 2 5. 8 424635 AA420687 Hs. 115455 Homo sapiens cDNA FLJ14259 fis, clone PL 5. 2 8. 4 436223 AK001884 Hs. 23799 ESTs 5. 2 2. 4 450649 Nom001429 Hs. 297722 HumanDNAsequencefromcloneRP1-85F18 5. 2 15. 3 441689 A1123705 Hs. 106932 ESTs 5. 2 2. 2 443392 A1055821 Hs. 293420 ESTs 5. 1 3. 3 416179 R19015 Hs. 79067 MAD (mothers against decapentaplegic, Dr 5. 1 16. 7 452167 N75238 Hs. 13075 Homo sapiens cDNA : FLJ23013 fis, clone L 5. 1 18. 7 434001 AW950905 Hs. 3697 serine (orcysteine) proteinaseinhibito 5. 0 24 458435 A ! 418718 Hs. 144121 ESTs, Weakly similar to dJ37E16. 2 [H. sap 5. 0 3. 9 433586 T85301 gb : yd78dO6. s1 Soares fetai liver spleen 5. 0 2. 8 452040 AW973242 Hs. 293690 ESTs 5. 0 4. 5 404029 5. 0 4. 3 421141 AW117261 Hs. 125914 ESTs 5. 0 2. 1 402605 4. 9 4. 2 435839 AF249744 Hs. 25951 Rho guanine nucleotide exchange factor (4. 9 2. 5 416404 AA180138 Hs. 107924 ESTs 4. 9 2. 4 435615 Y15065 Hs. 4975 potassium voltage-gated channel, KQT-lik 4. 9 7. 2 448425 At500359 Hs. 233401 ESTs 4. 9 4. 9

445773 H73456 Hs. 13299 Homo sapiens mRNA ; cDNADKFZp761M0111 (f 4. 9 2. 9 448451 AW015994 gb : UI-H-BIOp-abh-9-09-0 Ut. s1 NCt_CGAP_S 4. 9 2. 2 444838 AV651680 Hs. 208558 ESTs 4. 8 6. 7 452438 BE514230 Hs. 29595 JM4 protein 4. 8 2. 7 443898 AW804296 Hs. 9950 Sec61 gamma 4. 8 7. 2 452776 AA194540 Hs. 13522 ESTs 4. 8 3. 4 426108 AA622037 Hs. 166468 programmed cell death 5 4. 8 16. 7 416774 A1005169 Hs. 28274 Homo sapiens cDNA : FLJ22049 fis, clone H 4. 8 3. 2 427704 AW971063 Hs. 292882 ESTs 4. 8 23. 8 433588 A1056872 Hs. 133386 ESTs 4. 8 12. 8 410108 AA081659 Hs. 191098 KtAA1479 protein 4. 7 2. 1 433556 W56321 Hs. 111460 Homo sapiens cDNA : FU21715 fis, clone C 4. 7 11. 2 418962 AA714835 Hs. 271863 ESTs 4. 7 2. 2 404049 4. 7 3. 0 436222 A1208737 Hs. 122810 Homo sapiens cDNA FW11489 fis, ctone HE 4. 7 3. 3 425234 AW152225 Hs. 165909 ESTs 4. 7 3. 1 426490 NM001621 Hs. 170087 aryl hydrocarbon receptor 4. 7 9. 1 426514 BE616633 Hs. 301122 bone morphogenetic protein 7 (osteogenic 4. 7 2. 7 428722 U76456 Hs. 190787 fissue inhibitor of metalloproteinase 4 4. 6 6. 7 451989 AF169797 Hs. 27413 adaptor protein containing pH domain, PT 4. 6 13. 4 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 4. 6 18. 4 422488 A1679968 Hs. 152060 ESTs 4. 6 7. 7 428862 NMJM0346 Hs. 2316 SRY (sex-determining region Y)-box 9 (ca 4. 6 4. 6 413724 AA131466 Hs. 23767 Homo sapiens CDNA FU 12666 fis, clone NT 4. 5 11. 9 442495 A1184717 gb : qd64bO1. x1SoarestestisNHT Homo sap 4. 5 4. 5 403549 4. 5 11. 6 456209 W60633 Hs. 297792 ESTs 4. 5 5. 1 421181 Nua-005574 Hs. 184585 LlMdomånonly2 (rhombotin-tike1) 4. 5 10. 6 439566 AF086387 gb : HomosapiensfulllengthinsertcDNA 4. 4 2. 6 446329 NM 013272 Hs. 14805 solutecanierfamily21 (organicanion 44 17. 2 446488 AB037782 Hs. 15119 KIAA1361 protein 4. 4 8. 4 426110 NM002913 Hs. 166563 replication factor C (activator t) i (14 4. 4 2. 5 427413 BE547647 Hs. 177781 superoxide dismutase 2, mitochondrial 4. 4 14. 3 424340 AA339036 Hs. 7033 ESTs 4. 4 3. 9 421552 AF026692 Hs. 105700 secreted fizzled-related protein 4 4. 3 31. 1 422033 AW245805 Hs. 110903 claudin 5 (transmembrane protein deleted 4. 3 6. 1 434476 AW858520 Hs. 271825 ESTs 4. 3 4. 5 420582 BE047878 Hs. 99093 Homo sapiens chromosome 19, cosmid R2837 4. 3 3. 6 419904 AA974411 Hs. 18672 ESTs 4. 3 17. 1 407939 W05608 gb : za85e07. r1SoaresfetaUun9NbHL19W 4. 3 9. 0 425836 AW955696 Hs. 94842 ESTs 4. 3 3. 2 426304 AA374532 Hs. 297985 ESTs 4. 3 6. 6 439653 AW021103 Hs. 6631 hypothetical protein FLJ20373 4. 3 2. 3 424723 BE409813 Hs. 152337 protein arginine N-methyltransferase 3 (h 4. 3 2. 5 426064 BE387014 Hs. 166146 Homer, neuronal immediate early gene, 3 4. 2 4. 1 409509 AL036923 Hs. 127006 ESTs 4. 2 16. 4 424391 BE550112 Hs. 112712 ESTs 4. 2 3. 8 425248 AW957442 Hs. 252766 ESTs 4. 2 11. 1 418259 AA215404 Hs. 137289 ESTs 4. 2 19. 3 445525 BE149866 Hs. 14831 ESTs 4. 2 3. 1 414821 M63835 Hs. 77424 FcfragmentofigG, highaffinibla, re 4. 2 34. 8 430935 AW072916 Hs. 115654 ESTs 4. 2 3. 0 442233 AW967149 Hs. 28439 ESTs, Weakly similar to ORF2 [M. musculus 4. 2 2. 4 416959 D28459 Hs. 80612 ubiquitin-conjugatingen2ymeE2AtRAD6h 4. 1 15. 3 437097 N45312 Hs. 46506 ESTs 4. 1 15. 6 428189 AA424030 Hs. 46627 ESTs 4. 1 3. 6 434963 AW974957 Hs. 288719 Homo sapiens cDNA FLJ12142 fis, clone MA 4. 1 12. 2 425500 AB011541 Hs. 158200 EGF-like-domain, multiple 4 4. 1 2. 8 435177 Ai018174 Hs. 42936 ESTs 4. 1 2. 1 418357 Z44718 Hs. 301010 ESTs, Highly similar to AF159851 1 Rho G 4. 1 4. 1 419086 NM000216 Hs. 89591 Kalimann syndrome 1 sequence 4. 1 4. 1 436557 W15573 Hs. 5027 ESTs 4. 0 2. 1 425588 F07396 Hs. 46751 ESTs 4. 0 2. 2 423905 AW579960 Hs. 135150 lungbpe-tcellmembrane-associatedgly 4. 0 3. 6 437095 D14661 Hs. 119 Wilms'tumour 1-associating protein 4. 0 10. 0 425332 AA633306 Hs. 127279 ESTs 4. 0 10. 9 431556 AF016028 Hs. 260039 sarcospan (Kras oncogene-associated gene 4. 0 3. 8 427209 H06509 Hs. 92423 KIAA1566 protein 4. 0 3. 1 435468 AW362803 Hs. 166271 ESTs 4. 0 2. 2 416773 AK000340 Hs. 79828 hypothetical protein FLJ20333 4. 0 2. 6 440483 A1200836 Hs. 150386 ESTs 4. 0 2. 5 444821 AA053564 Hs. 12040 STE20-like kinase 4. 0 10. 4 433873 AW156913 Hs. 150478 ESTs, Weakly simiiar to KIAA0987 protein 4. 0 2. 3 420028 AB014680 Hs. 8786 carbohydrate (chondmian 6/keratan) sul 3 9 2. 8 446706 AW807631 Hs. 190488 hypothetical protein FLJ 10 120 3. 9 3. 8 424530 A1632083 Hs. 28511 ESTs 3. 9 2. 2 446851 AW007332 Hs. 16261 Homo sapiens cDNA : FLJ22063 fis, clone H 3. 9 16. 0 424720 M89907 Hs. 152292 SWIISNF related, matrix associated, acti 3. 9 4. 5 409456 U34962 Hs. 54473 cardiac-specific homeo box 3. 9 8. 0 420439 AW270041 Hs. 193053 eukaryotictranslaSoniniüationfactor 39 79 447340 AW961327 Hs. 280833 ESTs 3. 9 2. 1 430887 N66801 Hs. 260287 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 9 2. 5 409361 NMO5982 Hs. 54416 sineocutishomeobox (Drosophita) homo) o 3. 9 4. 6

426509 M31166 Hs. 2050 pentaxin-related gene, rapidly induced b 3. 9 4. 0 410079 U94362 Hs. 58589 glycogenin 2 3. 9 18. 3 426818 AA554827 Hs. 124841 ESTs. Weak ! ysimilartoAW5_HUMANAWS 3. 9 3. 0 435232 NM001262 Hs. 4854 cyctin-dependentkinaseinhibitor2C (p1 3. 8 4. 0 427228 AA115770 Hs. 174051 small nuclear ribonucleoprotein 70kD pol 3. 8 7. 9 443801 AW206942 Hs. 253594 ESTs 3. 8 3. 4 450746 D82673 Hs. 169921 general transcription factor 11, i, pseu 3. 8 2. 2 443837 Api984625 Hs. 9884 spindle pole body protein 3. 8 6. 5 435760 AF231922 Hs. 213004 chromosome 21 open reading frame 62 3. 8 2. 2 426757 AW205640 Hs. 158206 ESTs 3. 7 3. 1 443101 A ! 268936 Hs. 129872 sperm surface protein 3. 7 2. 4 440118 AB040893 Hs. 6968 K ! M1460protein 3. 7 3. 5 410612 AW502698 Hs. 118152 ESTs 3. 7 22. 5 435869 AF255910 Hs. 54650 vascutarendotheiia) junction-associated 3. 7 4. 2 433208 AW002834 Hs. 24095 ESTs 3. 7 16. 0 432357 AA452506 Hs. 274412 similar to yeast Upf3, variant A 3. 7 2. 6 413916 N49813 Hs. 75615 apolipoprotein GII 3. 7 5. 4 429766 AA612710 Hs. 146140 ESTs 3. 7 3. 2 437470 AL390147 Hs. 134742 hypothetical protein DKFZp547D065 3. 7 6. 4 438459 T49300 Hs. 35304 Homo sapiens cDNA FLJ13655 fis, clone PL 3. 7 10. 7 420361 N92054 Hs. 206910 ESTs 3. 7 18. 7 408819 AW163483 Hs. 48320 DKFZP566B1346 protein 3. 7 8. 8 411960 R77776 Hs. 18103 ESTs 3. 7 2. 3 435923 BE301930 Hs. 5010 Homo sapiens clone 24672 mRNA sequence 3. 7 2. 2 440145 AW021433 Hs. 250863 ESTs 3. 7 3. 8 453740 AL120295 gb : DKFZp761M067s1 761 (synonym : hamy2) 3. 6 3. 0 440975 AW499914 Hs. 7579 hypothetical protein FLJ10402 3. 6 2. 0 443135 A1376331 Hs. 156103 ESTs 3. 6 12. 4 419687 AI638859 Hs. 227699 ESTs, Weakly similar to Yhr217cp [S. cere 3. 6 2. 7 451029 AA852097 Hs. 25829 ras-related protein 3. 6 2. 9 414512 AL044336 Hs. 6831 golgi resident protein GCP60 3. 6 10. 5 410853 H04588 Hs. 30469 ESTs 3. 6 23. 9 419900 A1469960 Hs. 170698 ESTs 3. 6 3. 6 429673 AA884407 Hs. 211595 protein tyrosine phosphatase, non-recept 3. 6 7. 5 428290 A1932995 Hs. 183475 Homo sapiens done 25061 mRNA sequence 3. 6 9. 6 444381 BE387335 Hs. 283713 ESTs, Weakly similar to CA54_HUMAN COLLA 3. 6 4. 9 442104 L20971 Hs. 188 phosphodiesterase 4B, cAMP-specific (dun 3. 6 2. 1 441269 AW015206 Hs. 178784 ESTs 3. 6 2. 8 447961 W32791 Hs. 170405 ESTs 3. 5 4. 6 447735 AA775268 Hs. 6127 Homo sapiens cDNA : FW23020 fs, clone L 3. 5 2. 1 437580 AA761075 Hs. 293567 ESTs 3. 5 3. 5 447710 A1420523 Hs. 161282 ESTs 3. 5 3. 5 436446 AW016809 Hs. 119021 ESTs 3. 5 2. 2 448412 AI219083 Hs. 42532 ESTs, Moderatelysimi ! artoALU8_HUMANA 3. 5 4. 1 409712 AA167385 Hs. 13583 ESTs 3. 5 3. 8 404048 3. 5 3. 2 440516 S42303 Hs. 161 cadherin 2, type 1, N-cadherin (neuronal 3. 5 5. 1 409342 AU077058 Hs. 54089 BRCA1 associated RING domain 1 3. 5 10. 6 456508 AA502764 Hs. 123469 ESTs, Weakly similar to AF2088855 BM-01 3. 5 3. 8 426101 AL049987 Hs. 166361 Homo sapiens mRNA ; cDNADKFZp564F112 (fr 3. 5 32. 2 436252 At539519 Hs. 120969 Homo sapiens cDNA FLJ 11562 fis, clone HE 3. 5 4. 6 433854 AA610649 gb : np95cO3. s1 NC. _CGAP_Thyl Homosapiens 3. 5 3. 5 408495 W68796 Hs. 237731 ESTs 3. 5 6. 1 418801 AA228366 Hs. 115122 ESTs 3. 5 5. 1 422493 AW474183 Hs. 233816 ESTs 3. 5 15. 2 428141 D50402 Hs. 182611 solute carrier family 1 (proton-coupled 3. 5 2. 4 414591 A1888490 Hs. 55902 ESTs 3. 5 8. 3 439627 BE621702 Hs. 29076 Homo sapiens cDNA : FLJ21841 fis, clone H 3. 5 30. 2 44. 4969 A1203334 Hs. 160628 ESTs 3. 5 3. 1 435370 A1964074 Hs. 225838 ESTs 3. 5 3. 0 443228 W24781 Hs. 293798 ESTs 3. 4 4. 6 414612 BE274552 Hs. 76578 protein inhibitor of activated STAT3 3. 4 5. 0 437410 AW023340 Hs. 14880 ESTs 3. 4 2. 7 444172 BE147740 Hs. 104558 ESTs 3. 4 12. 9 428484 AF104032 Hs. 184601 solute carrier family 7 (cafionic amino 3. 4 2. 8 437860 AA333063 Hs. 279898 HomosapienscDNA : FLJ23165 fis, clone L 3. 4 4. 0 428776 AW016636 Hs. 155647 ESTs, Highly similar to R29144 1 (H. sapi 3. 4 2. 5 409493 AA386192 Hs. 193482 ESTs 3. 4 3. 4 432559 AW452948 Hs. 257631 ESTs 3. 4 6. 3 451455 A1937227 Hs. 8821 liver-expressed antimicrobial peptide 3. 4 6. 1 444153 AK001610 Hs. 10414 hypothetical protein FLJ10748 3. 4 2. 6 422872 BE326786 Hs. 187646 ESTs 3. 4 2. 2 414761 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homolog 2 3. 4 2. 6 416131 L03532 Hs. 79024 heterogeneousnuclearribonudeoprotein 3. 4 9. 5 408576 NM_003542 Hs. 46423 H4 histone family, member G 3. 4 3. 4 431770 BE221880 Hs. 268555 5'-3'exoribonuclease 2 3. 4 21. 2 426030 BE243933 Hs. 108642 zinc finger protein 22 (KOX 15) 3. 4 2. 1 422573 AW297985 Hs. 28777 H2A histone family, member L 3. 4 3. 7 436865 AW880358 Hs. 190488 hypothetical protein FLJ10120 3. 4 7. 6 442091 AW770493 Hs. 195904 guanine nucleotide binding protein (G pr 3. 4 2. 9 418699 BE539639 Hs. 173030 ESTs, Weakly similar to AlU8 HUMAN ALU S 3. 4 5. 5 434577 R37316 Hs. 179769 Homo sapiens cDNA : FU22487 fis, clone H 3. 4 3. 9 430314 AA369601 Hs. 239138 colony-enhancing factor 3. 4 16. 8

447279 AA325308 Hs. 18016 Homo sapiens mRNA ; cDNA DKFZp586H0324 (f 3. 3 3. 0 410020 T86315 Hs. 728 ribonuclease, RNase A family, 2 (liver, 3. 3 5. 8 447272 NM 014827 Hs. 17969 KIAA0663 gene product 3. 3 13. 4 407656 AW747986 Hs. 37443 Homo sapiens mRNA ; cDNA DKFZp434B2119 (f 3. 3 2. 3 435354 AA678267 Hs. 117115 ESTs 3. 3 5. 5 443884 N20617 Hs. 226627 tepGn receptor 3. 3 8. 6 444984 H15474 Hs. 12214 Homo sapiens clone 23716 MRNA sequence 3. 3 2. 0 431053 S40369 Hs. 249141 Glutamate receptor subunit 3. 3 2. 4 424682 AW604804 Hs. 151717 KIAA0437protein 3. 3 13. 7 457972 A1419060 Hs. 47448 ESTs 3. 3 4. 2 424762 AL119442 Hs. 183684 eukaryolic translation initiation factor 3. 3 3. 2 438666 AW014493 Hs. 126727 ESTs 3. 3 10. 8 447796 AW953622 Hs. 223025 RAB31, member RAS oncogene famity 3. 3 4. 2 426751 W92744 Hs. 22664 ESTs 3. 3 2. 6 436251 BE515065 Hs. 5092 nucieotar protein (KKBD repeat) 3. 3 3. 9 452688 AA721140 Hs. 49930 ESTs, WeaklysimiTartoB34087hypotheti 3. 3 4. 9 416359 AL042210 Hs. 16493 hypothetical protein DKFZp762N2316 3. 3 4. 2 424090 X99699 Hs. 139262 XIAP associated factor-1 3. 3 2. 9 434987 AW975114 Hs. 293273 ESTs 3. 3 2. 2 428642 NM_014899 Hs. 188006 KIAA0878 protein 3. 3 5. 7 420372 AW960049 Hs. 293660 ESTs, Weekly similar to A49618 probable 3. 3 5. 5 422224 NM_013982 Hs. 113264 neuregulin 2 3. 2 3. 0 432482 L19267 Hs. 275924 dystrophia myotonica-containing WD repea 3. 2 2. 7 439963 AW247529 Hs. 6793 platelet-acbvafing factor ace@ ! hydro ! a 3. 2 2. 0 428418 A1368826 Hs. 30654 ESTs 3. 2 2. 4 416728 AB024597 Hs. 79658 casein kinase 1, epsilon 3. 2 2. 8 416224 NM002902 Hs. 79088 reticutocatbin 2, EF-hand calcium bindin 3. 2 2. 2 429803 W81489 Hs. 223025 RAB31, member RAS oncogene family 3. 2 4. 3 431387 A1878854 Hs. 252229 v-maf musculoaponeurotic fibrosarcoma (a 3. 2 2. 8 404171 3. 2 35. 8 435575 AF213457 Hs. 44234 triggering receptor expressed on myetoid 3. 2 2. 6 426421 AW367884 Hs. 169832 zinc finger protein 42 (myeloid-specific 3. 2 3. 8 445070 NM 000677 Hs. 258 adenosine A3 receptor 3. 2 7. 6 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 3. 2 82. 0 446006 NM 004403 Hs. 13530 deafness, autosomal dominant5 3. 2 2. 2 430890 X54232 Hs. 2699 glypican 1 3. 2 4. 3 439807 AA376417 Hs. 173501 Homo sapiens mRNA for FU00008 protein, 3. 2 2. 3 430412 AW341754 Hs. 189305 ESTs 3. 2 2. 0 442807 AL049274 Hs. 8736 Homo sapiens mRNA ; cDNA DKFZp564H203 (fr 3. 2 2. 7 420253 A1656055 Hs. 96200 neighbor of A-kinase anchoring protein 9 3. 2 2. 9 436042 AP284422 Hs. 119178 cationXch. oridecotransporter-interachn 3. 2 4. 6 423422 AC005175 Hs. 128425 NY-REN-24 antigen 3. 2 4. 0 413020 R98736 gb : yr31h09. r1 Soaresfetalliverspleen 3. 2 4. 1 452877 A1250789 Hs. 32478 ESTs 3. 2 4. 0 418113 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 3. 1 9. 0 421097 Api280112 Hs. 125232 Homo sapiens CDNA FUl 3266 fis, clone OV 3. 1 2. 0 450219 A1826999 Hs. 224624 ESTs 3. 1 23. 7 434256 A1378817 Hs. 191847 ESTs 3. 1 3. 4 421407 T82331 Hs. 127453 ESTs 3. 1 3. 9 451198 AW964541 Hs. 11500 HomosapienscDNA : FLJ21127 fis, clone C 3. 1 3. 9 445664 AW968638 Hs. 237691 ESTs 3. 1 7. 9 411089 AA456454 Hs. 118637 HomosapienscDNAFW13365fis, ctonePL 3. 1 6. 0 458050 AA834708 gb : od99d04. s1 NCI CGAP_Ov2 Homo sapiens 3. 1 4. 4 454140 AB040888 Hs. 41793 hypothetical protein FU10474 3. 1 Z7 417270 AA429615 Hs. 98593 HomosapienscDNA : FLJ23233 fis, clone C 3. 1 2. 4 427951 A1826125 Hs. 43546 ESTs 3. 1 2. 3 443693 At344782 Hs. 9683 protein-kinase, interferon-inducible dou 3. 1 7. 2 413367 NM_006517 Hs. 75317 solute carrier family 16 (monocarboxylic 3. 1 2. 6 429402 AP116571 Hs. 201671 SRY (sexdetemminingregionY ;-box13 3. 1 6. 5 447752 M73700 Hs. 347 iactotransferrin 3. 1 19. 4 408949 AF189011 Hs. 49163 putative dbonuclease 111 3. 1 3. 7 418039 R06859 Hs. 193172 ESTs 3. 1 3. 8 447343 AA256641 Hs. 236894 ESTs, Highly similar to LRP1 HUMAN LOW-D 3. 1 2. 2 424441 X14850 Hs. 147097 H2Ahistonefamify, memberX 3. 1 3. 2 435163 AA668884 Hs. 19155 ESTs 3. 1 2. 1 428712 AW085131 Hs. 190452 KIAA0365 gene product 3. 1 2. 7 434542 AA769310 Hs. 61260 hypothetical protein FLJ13164 3. 1 14. 3 428147 AW629965 Hs. 234983 ESTs 3. 1 2. 7 415825 Y18024 Hs. 78877 inositol1, 4, 5-trisphosphate3-kinaseB 3. 1 2. 5 422170 A1791949 Hs. 112432 anti-Mullerian hormone 3. 1 8. 1 448801 N57423 Hs. 179898 HSPC055 protein 3. 0 2. 0 413542 BE295928 Hs. 75424 inhibitorofDNAbinding1, dominantneg 3. 0 18. 3 431562 A1884334 Hs. 11637 ESTs 3. 0 3. 9 410274 AA381807 Hs. 61762 hypoxia-inducible protein 2 3. 0 3. 0 458962 NM 005859 Hs. 25180 purine-rich element binding protein A 3. 0 3. 0 436277 R88520 Hs. 120917 ESTs 3. 0 2. 7 453288 AW583292 Hs. 274412 similar to yeast Upf3, variant A 3. 0 3. 0 447471 AF039843 Hs. 18676 sprouty (Drosophila) homolog 2 3. 0 4. 1 442554 AW467376 Hs. 129640 ESTs 3. 0 4. 7 441466 AW673081 Hs. 54828 ESTs 3. 0 3. 0 420297 Api628272 Hs. 88323 ESTs 3. 0 8. 1 445101 T75202 Hs. 12314 Homo sapiens mRNA ; cDNA DKFZp586C1019 (f 3. 0 18. 7 453405 A1567972 Hs. 49919 ESTs 3. 0 9. 6

434521 NM_002267 Hs. 3886 karyopherin alpha 3 (importin aipha 4) 3. 0 9. 3 447948 Al620923 Hs. 46679 ESTs 3. 0 10. 1 445756 AA290690 Hs. 288493 ESTs 3. 0 3. 5 413243 AA769266 Hs. 193657 ESTs 3. 0 5. 9 422845 AA317841 Hs. 301838 ESTs, WeaklysimilartoALU1_HUMANALUS 3. 0 2. 2 419409 AW297831 Hs. 143792 ESTs 3. 0 2. 1 446441 AK001782 Hs. 15093 hypothetical protein 3. 0 2. 1 427150 BE616183 Hs. 173737 ras-related C3 botulinum toxin substrate 3. 0 4. 1 421043 BE379455 Hs. 89072 ESTs 3. 0 3. 0 427239 BE270447 Hs. 174070 ubiquitin carrier protein 3. 0 4. 1 433312 At241331 Hs. 131765 ESTs 3. 0 11. 0 415102 M31899 Hs. 77929 excision repair cross-complementing rode 3. 0 6. 0 414702 L22005 Hs. 76932 cell division cycle 34 3. 0 3. 3 428673 AW601325 Hs. 274472 high-mobility group (nonhistone chromoso 3. 0 15. 8 422676 D28481 Hs. 1570 histamine receptor H1 3. 0 2. 1 451693 BE220445 Hs. 279635 ESTs 3. 0 2. 3 412420 AL035668 Hs. 73853 bone morphogenetic protein 2 3. 0 10. 5 424005 AB033041 Hs. 137507 KIAA1215 protein 3. 0 3. 9 440769 BE561793 gb : 601346842F1 NIH MGC_8 Homo sapiens cD 3. 0 5. 1 428832 AA578229 gb : nt22b12. s1 NCI_CGAP_HSC1 Homo sapiens 3. 0 2. 3 430293 Ai416988 Hs. 238272 inositol1, 4, 5tdphosphatereceptor, ty 3. 0 6. 3 450883 Nul001348 Hs. 25619 death-associated protein kinase 3 3. 0 5. 6 407879 AA045464 Hs. 6557 ESTs 2. 9 7. 0 426167 AF039023 Hs. 167496 Homo sapiens cDNA FLJ 11120 fis, clone PL 2. 9 2. 6 435281 AB020699 Hs. 4864 KIAA0892 protein 2. 9 3. 9 432339 AW411259 Hs. 25945 ESTs 2. 9 2. 9 440524 R71264 Hs. 16798 ESTs 2. 9 9. 7 408083 BE383668 Hs. 42484 hypotheticaproteinFW10618 2. 9 4. 4 427729 AB0331 00 Hs. 300646 HomosapienscDNAFW11744fis, c ! oneHE 2. 9 3. 1 422072 AB018255 Hs. 111138 KtM0712geneproduct 2. 9 2. 9 435904 AF261655 Hs. 8910 1, 2-alpha-mannosidase IC 2. 9 3. 6 440100 BE382685 Hs. 158549 ESTs 2. 9 3. 6 448356 AL120837 Hs. 20993 high-glucose-regulated protein 8 2. 9 13. 9 428005 AW302245 Hs. 181390 casein kinase 1, gamma 2 2. 9 3. 7 403019 AA834626 Hs. 66718 RAD54 (S. cerevisiae)-like 2. 9 5. 8 419175 AW270037 Hs. 179507 KIAA0779 protein 2. 9 2. 3 433592 NM_004642 Hs. 3436 deleted in oral cancer (mouse, homolog) 2. 9 2. 3 413922 A1535895 Hs. 221024 ESTs 2. 9 2. 8 428593 AW207440 Hs. 185973 degenerativespemmatocyte (homologDroso 2. 9 3. 3 441789 D52059 Hs. 7972 KIM0871 protein 2. 9 2. 1 459107 AA811881 Hs. 28505 ubiquitin-conjugating enzyme E2H (homolo Z9 2. 8 448560 BE613183 Hs. 23213 ESTs 2. 9 3. 0 425304 AA463844 Hs. 31339 fibroblastgrowthfactor11 2. 9 3. 3 434846 AW295389 Hs. 119768 ESTs 2. 9 5. 1 408146 R45621 Hs. 81057 ESTs, ModeratetysimilartoCL3BCtR. nor 2. 9 5. 1 446644 NM 003272 Hs. 15791 transmembrane 7 superfamily member1 (up 2. 9 2. 8 446808 AA703226 Hs. 16193 HomosapiensmRNA ; cDNA DKFZp586B211 (fr 2. 9 8. 5 433017 Y15067 Hs. 279914 zinc finger protein 232 2. 9 2. 2 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactin) 2. 9 4. 5 444706 AK000398 Hs. 11747 hypothetical protein FLJ20391 2. 9 3. 6 407925 BE002320 Hs. 287864 Homo sapiens cDNA FLJ14030 fis, clone HE 2. 9 2. 1 431730 AF208856 Hs. 268122 hypothetical protein 2. 9 2. 5 447118 AB014599 Hs. 17411 KlM0699protein 2. 8 2. 1 453496 AA442103 Hs. 33084 solute carrier family 2 (facilitated glu 2. 8 7. 4 425227 H84455 Hs. 40639 ESTs 2. 8 2. 3 456534 X91195 Hs. 100623 phospholipase C, beta 3, neighbor pseudo 2. 8 76. 2 421465 AK001020 Hs. 104627 Homo sapiens cDNA F1J10158 fis, clone HE 2. 8 6. 1 409095 AW337272 Hs. 293656 ESTs 2. 8 34. 0 424066 Z99348 Hs. 112461 ESTs 2. 8 2. 1 432945 AL043683 Hs. 271357 ESTs, Weakly similar to unnamed protein 2. 8 11. 9 414079 H19184 Hs. 205230 ESTs 2. 8 2. 1 414359 M62194 Hs. 75929 cadherin11, type2, 0Bcadherin (osteob 2. 8 3. 9 438890 AA827756 Hs. 135049 ESTs 2. 8 4. 9 430354 AA954810 Hs. 239784 human homolog of Drosophila Scribble 2. 8 5. 2 458367 AA088470 Hs. 83135 p53-responsive gene 6 2. 8 4. 4 412014 A1620650 Hs. 43761 ESTs 2. 8 4. 8 428727 AF078847 Hs. 191356 general transcription factor IIH, polype 2. 8 6. 7 447942 F12628 Hs. 155470 zinc finger protein 38 (KOX 25) 2. 8 2. 2 426432 AF001601 Hs. 169857 paraoxonase2 2. 8 3. 5 439189 A1951185 Hs. 144630 nuclear receptor subfamily 2, group F, m 2. 8 2. 5 446756 AW028485 Hs. 26136 ESTs 2. 8 4. 1 432148 AW504912 Hs. 81907 ESTs, Moderately similar to ALU4_HUMAN A Z8 2. 6 405649 2. 8 3. 8 414473 BE302693 gb : ba74cO2. y1 NlH_MGC_20HomosapienscD 2. 8 2. 4 443839 AW139834 Hs. 143321 ESTs 2. 8 2. 1 448804 AW512213 HsA2500 ADP-ribosylaSon fætof-like S 2. 8 2. 7 426825 AL133415 Hs. 2064 vimentin 2. 8 25. 0 417528 H47315 Hs. 27519 ESTs 2. 8 11. 6 453657 W23237 Hs. 296162 ESTs 2. 8 3. 2 432714 Y12059 Hs. 278675 bromodomain-containing 4 2. 8 6. 7 441072 AW275480 Hs. 39504 ESTs 2. 7 Z7 441297 AW403084 Hs. 7766 ubiquitin-conjugating enzyme E2E 1 (homo 2. 7 2. 2 443849 BE566066 Hs. 9893 ASB-3 protein 2. 7 3. 0

408243 Y00787 Hs. 624 intedeukin 8 2. 7 3. 8 446243 BE296396 Hs. 14512 HomosapienscDNAFW11761 fis, ctoneHE 2. 7 3. 3 432238 AL133057 Hs. 274135 HomosapiensmRNA ; cDNA DKFZp434K1815 (f 2. 7 3. 0 433944 AL117518 Hs. 3686 KIAA0978 protein 2. 7 3. 1 411400 AA311919 Hs. 69851 GAR1 protein 2. 7 16. 0 436840 AW450376 Hs. 130803 ESTs, Highiy similar to T00367 hypotheti 2. 7 4. 1 428281 AA194554 Hs. 183434 ATPase, H+transporGng, lysosomal (vacu 2. 7 3. 2 426340 Z97989 Hs. 169370 FYN oncogene related to SRC, FGR, YES 2. 7 2. 0 408320 A1125867 Hs. 20734 ESTs 2. 7 4. 7 422363 T55979 Hs. 115474 replication factor C (activator 1) 3 (38 2. 7 2. 2 436440 M471862 Hs. 196008 Homo sapiens cDNA FLJ11723 fis, clone HE 2. 7 4. 7 408912 AB011084 Hs. 48924 K) AA0512 gene product 2. 7 2. 1 419304 Api271326 Hs. 146101 ESTs 2. 7 3. 4 415045 AA321559 Hs. 38270 Homo sapiens cDNA : FLJ20984 fis, clone C 2. 7 2. 3 441872 BE567100 Hs. 154938 hypothetical protein MDS025 2. 7 2. 3 422343 AI628633 gb : ty77dO5. x1 NCt_CGAP_Kid11 Homo sapien 2, 7 2. 5 415539 A1733881 Hs. 72472 ESTs 2. 7 2. 7 443B23 BE089782 Hs. 9877 hypothetical protein 2. 7 4. 7 419881 AA329340 Hs. 44649 ESTs 2. 7 3. 3 429155 BE242291 Hs. 197540 hypoxia-inducibie factor I, alpha subuni 2. 7 5. 5 431319 AA873350 gb : oh64hO2. s1 NCl_CGAP_KidSHomosapiens 2. 7 65. 9 430219 X99209 Hs. 235887 HMT1 (hnRNP methyltransferase, S. cerevi 2. 7 3. 1 421016 AA504583 Hs. 101047 transcription factor 3 (E2A immunogiobul 2. 7 5. 2 417259 AW903838 Hs. 81800 chondroitin sulfate proteoglycan 2 (vers 2. 7 10. 7 431747 AW979134 Hs. 10700 hypothetical protein 2. 7 2. 9 408085 N25929 Hs. 42500 ADP-ribosylation factor-like 5 2. 7 7. 8 426218 AF119043 Hs. 168005 transcriptionalintermediary factorl ga 2. 7 4. 5 434845 BE267057 Hs. 4200 hypothetical protein R32184_1 2. 7 4. 6 451644 N23235 Hs. 30567 ESTs 2. 7 2. 3 428408 W74437 Hs. 188757 Homo sapiens mRNA ; cDNA DKFZp564M113 (fr 2. 7 5. 7 446627 A1973016 Hs. 15725 hypothetical protein SBBI48 2. 7 2. 9 450167 AA446404 Hs. 24563 NTF2-related export protein 1 2. 7 9. 9 408821 AL050385 Hs. 48332 N ! MA (never in mitosis gene a)-related k 2. 7 2. 1 452068 W76412 Hs. 57877 ESTs 2. 7 2. 1 431129 AL137751 Hs. 263671 Homo sapiens mRNA ; CDNA DKFZp43410812 (f 2. 7 6. 2 429025 A1399910 Hs. 4842 ESTs 2. 7 2. 9 421114 AW975051 Hs. 293156 ESTs 2. 7 8. 8 428755 D87454 Hs. 192966 KIAA0265 protein 2. 7 3. 0 416391 A1878927 Hs. 79284 mesoderm specific transcript (mouse) hom 2. 7 5. 7 414283 AW960011 Hs. 154993 ESTs 2. 7 5. 9 425262 D87119 Hs. 155418 GS3955 protein 2. 7 3. 7 447726 AL137638 Hs. 19368 Homo sapiens mRNA ; cDNA DKFZp434J065 (fr 2. 7 14. 3 424623 AW963062 Hs. 165809 ESTs 2. 7 5. 6 444772 AW450800 Hs. 176859 ESTs 2. 7 2. 7 428419 U49436 Hs. 286236 eukaryotic translation initiation factor 2. 7 4. 6 441049 W88920 Hs. 29341 hypothetical protein FLJ22376 2. 7 4. 5 412758 Y07818 Hs. 74566 dihydropyrimidinase-like 3 2. 6 5. 1 447720 AL038765 Hs. 161304 ESTs 2. 6 3. 2 419708 AK000753 Hs. 92374 hypothetical protein 2. 6 3. 0 445502 AW379160 Hs. 12813 DKFZP434J214 protein 2. 6 5. 0 437370 AL359567 Hs. 161962 Homo sapiens mRNA ; cDNA DKFZp547D023 (fr 2. 6 2. 9 444147 AB002306 Hs. 10351 KIAA0308 protein 2. 6 6. 8 433193 AB040881 Hs. 32580 Homo sapiens cDNA FLJ13122 fis, clone NT 2. 6 3. 2 445439 BE243084 Hs. 12719 regulator of nonsense transcripts 1 2. 6 3. 9 450309 W61348 Hs. 4864 KIAA0892 protein 2. 6 3. 8 422092 AB007883 Hs. 111373 KIAA0423 protein 2. 6 2. 3 424118 BE269041 Hs. 140452 cargo selection protein (mannose 6 phosp 2. 6 5. 5 407618 AW054922 Hs. 53478 HomosapienscDNAFLJ12366fis cloneMA 2. 6 2. 9 446493 AK001389 Hs. 15144 hypothetical protein DKFZp5640043 2. 6 3. 2 442878 A1868648 Hs. 22315 ESTs 2. 6 4. 7 448771 BE315511 Hs. 296244 SNARE protein 2. 6 5. 0 416611 AA568308 Hs. 192789 ESTs, WeaklysimilartoAW7_HUMANAWS 2. 6 7. 7 409348 A1401535 Hs. 146090 ESTs 2. 6 3. 5 439349 At660898 Hs. 195602 ESTs 2. 6 3. 2 428433 AA521410 Hs. 41371 ESTs Z6 7. 9 436565 BE547674 Hs. 204169 ESTs 2. 6 3. 0 438662 AA223599 Hs. 6351 cleavage and polyadenylation specific fa 2. 6 2. 6 429362 T25833 Hs. 200478 ubiquiEn-conjugating enzyme E2M (homolo 2. 6 2. 3 459035 AW291109 Hs. 208787 ESTs 2. 6 2. 6 451814 AA847992 Hs. 137003 ESTs 2. 6 19. 1 452331 AA598509 Hs. 29117 H. sapiens MRNA for pur alpha extended 3 2. 6 2. 2 438461 AW075485 Hs. 286049 phosphoserine aminotransferase 2. 6 2. 1 424362 AL137646 Hs. 146001 Homo sapiens mRNA ; cDNA DKFZp586F0824 (f 2. 6 4. 9 423699 H41850 Hs. 131846 PCAF associated factor 65 alpha 2. 6 3. 7 441226 BE563042 Hs. 118820 ESTs 2. 6 2. 5 444940 AK002148 Hs. 12151 hypothetical protein Fou11286 2. 6 3. 4 448731 A1522273 Hs. 42640 ESTs 2. 6 3. 2 424250 AF073310 Hs. 143648 insulin receptor substrate 2 2. 6 2. 5 433468 AA832055 Hs. 232217 ESTs, WeaklysimilartoALU1_HUMANALUS 2. 6 3. 3 419925 AA159850 Hs. 93765 lipoma HMGIC fusion partner 2. 6 4. 6 441364 AW450466 Hs. 126830 ESTs 2. 6 2. 6 425922 AL157466 Hs. 162751 Homo sapiens mRNA ; cDNA DKFZp761 E2423 (f 2. 5 2. 7 434974 AA778711 Hs. 4310 eukaryotic translation initiation factor 2. 5 2. 5

408392 U28831 Hs. 44566 KIAA1641 protein 2. 5 25. 4 432426 AW973152 Hs. 31050 ESTs zs 10. 0 436623 A1417073 Hs. 107265 ESTs 2. 5 2. 1 452683 A1089575 Hs. 9071 progesterone membrane binding protein 2. 5 2. 6 410582 AW867197 Hs. 14562 Homo sapiens cDNA : FU21616 fis, clone C 2. 5 3. 7 441328 A1982794 Hs. 159473 ESTs 2. 5 9. 2 453983 H94997 Hs. 16450 ESTs 2. 5 26. 1 438826 R26709 Hs. 10095 hypothetical protein from EUROIMAGE 1669 2. 5 2. 3 427899 AA829286 Hs. 181062 senumamyloidA1 2. 5 20. 3 427820 BE222494 Hs. 180919 inhibitor of DNA binding 2, dominant neg 2. 5 3. 5 458933 AI638429 Hs. 24763 RAN binding protein 1 2. 5 3. 5 444871 U46386 Hs. 12102 sorting nexin 3 2. 5 2. 3 411329 AL360265 Hs. 69554 hypotheticai protein FLJ20552 2. 5 2. 9 424074 A1902456 Hs. 210761 ESTs 2. 5 4. 0 438988 H30039 Hs. 107674 ESTs 2. 5 2. 7 412836 AA121384 Hs. 191446 ESTs 2. 5 5. 7 430189 A1298841 Hs. 135133 ESTs, Weakly similar to ORF YNL310c [S. c 2. 5 3. 0 432841 M93425 Hs. 62 protein tyrosine phosphatase, non-recept 2. 5 13. 4 416926 H03109 Hs. 108920 HT018 protein 2. 5 2. 8 451429 AA525993 Hs. 173699 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 5 3. 9 416388 A1417358 Hs. 73677 ESTs 2. 5 4. 2 421561 Z45399 Hs. 105779 protein inhibitor of activated STAT prot 2. 5 7. 5 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel Z5 26 416273 AW575691 Hs. 79123 KIAA0084protein 2. 5 2. 6 427149 H94688 Hs. 173737 ras-related C3 botulinum toxin substrate 2. 5 2. 6 453041 Api680737 Hs. 289068 transcription factor 4 2. 5 2. 2 446899 NM005397 Hs. 16426 podocalyxin-like 2. 5 4. 7 447301 AW958124 Hs. 142442 HP1-BP74 2. 5 3. 2 447769 AW873704 Hs. 48764 ESTs 2. 5 2. 4 447754 AW073310 Hs. 163533 Homo sapiens cDNA FLJ14142 fis, clone MA 2. 5 Z5 427087 BE073913 Hs. 173515 uncharacterized hypothalamus protein HTO 2. 5 23. 6 440903 A) 468079 Hs. 126623 ESTs 2. 5 2. 3 432353 NM_016558 Hs. 274411 SCAN domain-containing 1 2. 5 4. 1 408196 AL034548 Hs. 43627 SRY (sex determining region Y)-box 22 25 25 411373 BE326276 Hs. 8861 ESTs 2. 5 3. 9 452402 Al138530 Hs. 22216 peroxisome proliferative activated recep 2. 5 2. 4 429998 At458063 Hs. 57841 ESTs 2. 5 2. 6 421772 Z24958 Hs. 108139 zinc finger protein 212 2. 5 3. 7 442573 H93366 Hs. 7567 HomosapienscDNAFLJ21962fis, ctoneH 2. 5 21 444677 AL110212 Hs. 9Z42 purine-rich element binding protein B 2. 5 3. 4 441887 AW967865 Hs. 92145 ESTs 2. 5 3. 3 451031 A1360187 Hs. 4254 ESTs 2. 5 4. 8 432450 A1990739 Hs. 77868 ORF 2. 5 2. 4 415860 D56051 Hs. 78888 diazepam binding inhibitor (GABA recepto 2. 5 4. 8 439630 AA313607 Hs. 58633 Homo sapiens cDNA : FLJ22145 fis, clone N 2. 4 2. 3 428607 AB002353 Hs. 186840 KtM0355geneproduct 2. 4 4. 0 415402 AA164687 Hs. 297889 ESTs 2. 4 2. 5 446888 AL030996 Hs. 16411 hypothetical protein LOC57187 2. 4 2. 2 439208 AK000299 Hs. 180952 dynactin p62 subunit 2. 4 2. 4 452900 AA626794 Hs. 250655 prothymosin, alpha (gene sequence 28) 2. 4 3. 4 408657 AA782601 Hs. 173328 protein phosphatase 2, regulatory subuni 2. 4 3. 6 439143 AI359214 Hs. 179260 ESTs 2. 4 2. 5 439867 AA847510 Hs. 161292 ESTs 2. 4 9. 3 408138 AA535740 Hs. 301967 Homo sapiens mRNA ; cDNADKFZp434M196 (fr 2. 4 5. 6 428386 R17298 Hs. 295923 seven in absentia (Drosophila) homolog 1 2. 4 4. 2 417289 D86962 Hs. 81875 growth factor receptor-bound protein 10 2. 4 2. 2 405268 2. 4 3. 1 439734 AC005013 Hs. 149 cAMP response element-binding protein CR 2. 4 3. 6 445378 AV653564 Hs. 226946 ESTs 2. 4 2. 4 454085 D82418 Hs. 29626 ESTs, Weakly similar to unknown [D. melan 2. 4 22. 0 427354 T57896 Hs. 191095 ESTs 2. 4 3. 6 452906 BE207039 Hs. 75621 serine (orcysteine) proteinaseinhibito 2. 4 2. 2 450065 AL050107 Hs. 301558 DKFZP58611419 protein 2. 4 3. 6 451091 AA810932 Hs. 131899 ESTs, Weakly similar to coded for by C. 2. 4 2. 7 414839 X63692 Hs. 77462 DNA (cytosine-5-)-methyltransferase 1 2. 4 2. 6 420303 AA258282 Hs. 278436 KIAA1474 protein 2. 4 2. 0 437068 AA743643 Hs. 291427 ESTs 2. 4 2. 6 417446 AL118671 Hs. 82163 monoamine oxidase B 2. 4 4. 4 421454 A1660389 Hs. 286108 chorionic somatomammotropin hormone 1 (p 2. 4 3. 5 434943 A1929819 Hs. 320 xeroderma pigmentosum, complementation g 2. 4 6. 4 446342 BE298665 Hs. 14846 Homo sapiens mRNA ; cDNA DKFZpS64D016 (fr 2. 4 3. 0 452847 AK000857 Hs. 30783 hypothetical protein FU20850 2. 4 2. 1 422506 R20909 Hs. 117816 sorcin 2. 4 2. 2 405204 2. 4 4. 3 419441 AW023731 Hs. 274368 Homo sapiens mRNA ; cDNA DKFZp58611524 (f 2. 4 11. 7 442293 AW292634 Hs. 150358 ESTs 2. 4 21 451484 AV648896 Hs. 26461 hypothetical protein 2. 4 2. 0 438545 AB032977 Hs. 6298 KIAA1151 protein 2. 4 2. 1 442724 AA355525 Hs. 159604 cysteinyl-tRNAsynthetase 2. 4 2. 8 405517 2. 4 6. 6 413822 R08950 Hs. 272044 ESTs, Weaklysimi. artoALUl_HUMANALUS Z4 3. 8 445679 At343868 Hs. 58800 Homo sapiens cDNA FU12488 fis, clone NT 2. 4 2. 3 408636 BE294925 Hs. 46680 CGI-12 protein 2. 4 8. 1

409142 AL136877 Hs. 50758 chromosome-associated polypeptide C 2. 4 2. 4 422043 AL133649 Hs. 110953 Homo sapiens mRNA ; cDNA DKFZp434A139 (fr 2. 4 2. 1 424687 J05070 Hs. 151738 matdx metalloproteinase 9 (gelatinase 8 2. 4 2. 6 442560 AA365042 Hs. 228598 ESTs 2. 4 4. 9 418126 T91451 Hs. 86538 ESTs 2. 4 11. 7 413313 NM_002047 Hs. 75280 glycyl-tRNA synthetase 2. 4 2. 1 415167 M160784 Hs. 26410 ESTs 2. 4 4. 4 440040 BE219431 Hs. 300713 ESTs 2. 4 a4 443595 AF169312 Hs. 9613 PPAR (gamma) angiopoietin related protein 2. 4 10. 7 438977 M482026 Hs. 298625 ESTs 2. 4 2. 8 452066 AA772149 Hs. 16979 ESTs 2. 4 5. 4 428500 AI815395 Hs. 184641 detta-6fattyaciddesaturase 2. 4 2. 2 408503 AW119059 Hs. 63163 ESTs, Weakly simiiar to UDP-GaINAc : polyp 2. 4 2. 7 433401 AF039698 Hs. 284217 serologicafly deftned colon cancer antig 2. 4 4. 8 412676 Nul000165 Hs. 74471 gapjunction protein, alpha 1, 43kD (con 2. 4 2. 2 453753 BE252983 Hs. 35086 ubiquitin specific protease 1 2. 4 2. 8 424050 AA211218 Hs. 138381 famesyttransferase. CAAX box, alpha 2. 4 3. 9 440225 BE295782 Hs. 159 tumor necrosis factor receptor superfami 2. 4 76. 7 430512 AF182294 Hs. 241578 U6 snRNA-associated Sm-like protein LSm8 2. 4 12. 3 415156 X84908 Hs. 78060 phosphorylase kinase, beta 2. 4 10. 4 435975 AL118990 Hs. 41997 aNpha-1-Bglycoprotein 2. 4 7. 7 429831 AA564489 Hs. 137526 ESTs 2. 4 4. 1 407373 AA031576 Hs. 143812 HomosapienscDNAFW12956fis, cloneNT Z4 3. 3 422221 AA306649 gb : EST177656 Jurkat T-celis VtHomo sapi 2. 4 3. 8 451351 AW058261 Hs. 168213 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 4 3. 3 410082 AA081594 Hs. 158311 Musashi (Drosophila) homolog1 2. 4 2. 5 430304 AL122071 Hs. 238927 Homo sapiens mRNA ; cDNA DKFZp434H1235 (f Z4 6. 5 418863 AL135743 Hs. 25566 ESTs 2. 4 5. 2 448414 BE391820 Hs. 21145 Homo sapiens cDNA : FU22489 fis, clone H 2. 4 3. 7 428351 AK001701 Hs. 183779 Homo sapiens cDNA FLJ10590 fis, clone NT 2. 4 6. 2 425750 AL050276 Hs. 159456 zinc finger protein 288 2. 4 5. 1 426295 AW367283 Hs. 75839 zinc finger protein 6 (CMPX1) 2. 4 113. 6 408772 W88532 Hs. 254562 ESTs 2. 4 12. 3 426307 F24978 Hs. 294084 ESTs 2. 4 4. 0 405203 2. 4 2. 5 453537 AA036755 Hs. 283681 ESTs 2. 4 3. 6 431427 AK000401 Hs. 252748 Homo sapiens c DNA FLJ20394 fis, clone KA 2. 4 6. 2 458021 At885190 Hs. 156089 ESTs, Weak ! ysimitartoKtM1339protein 2. 4 4. 3 453928 BE222198 Hs. 143851 ESTs 2. 4 2. 6 446853 AV660630 Hs. 87627 disrupter of silencing 10 2. 3 9. 7 441626 AA281167 Hs. 111911 ESTs 2. 3 23. 0 446138 AW504182 Hs. 13999 KIAA0700 protein 2. 3 2. 2 452568 AA805634 Hs. 3337 transmembrane 4 superfamily member 1 2. 3 22. 2 417665 AW852858 Hs. 22862 ESTs 2. 3 8. 0 420088 AC006486 Hs. 298033 Homo sapiens cDNA : FLJ22286 fis, clone H 2. 3 5. 1 421456 AW579842 Hs. 104557 hypothetical protein FLJ 10697 2. 3 2. 5 412093 BE242691 Hs. 14947 ESTs 2. 3 31. 4 428172 U09367 Hs. 182828 zinc finger protein 136 (clone pHZ-20) 2. 3 4. 9 450447 AF212223 Hs. 2501 0 hypothetical protein P15-2 2. 3 2. 3 436001 AW903849 Hs. 173840 HUEL (C4orf1)-interactingprotein 2. 3 4. 1 414786 A1246482 Hs. 249989 ESTs 2. 3 2. 1 459284 AF155660 Hs. 34401 mitochondriå solute carrier 2. 3 2. 9 452701 Nit_005110 Hs. 30332 g ! utamine-fructose-6-phosphatetransamin Z3 2. 6 446320 AF126245 Hs. 14791 acyl-Coenzyme A dehydrogenase family, me 2. 3 3. 9 446669 AW972832 Hs. 29468 ESTs 2. 3 3. 8 434616 D79338 Hs. 239720 CGR4-NOTtranscripSoncomplex, subunit Z3 a6 452135 M492175 Hs. 301805 ESTs 2. 3 2. 3 408696 AW958157 Hs. 16542 ESTs 2. 3 2. 8 436176 AL121422 Hs. 184013 ESTs, Highly similar to unnamed protein 2. 3 3. 2 419713 AW968058 Hs. 92381 nudix (nucleoside diphosphate linked moi 2. 3 17. 0 414197 W44877 Hs. 55501 ESTs 2. 3 11. 8 445270 At762154 Hs. 54982 Homo sapiens cDNA FLJ14014 fis, clone HE 2. 3 4. 2 412247 AF022375 Hs. 73793 vascularendothelialgrowthfactor 2. 3 5. 1 426494 AL119528 Hs. 170098 K) AA0372gene product 2. 3 4. 4 405687 2. 3 2. 2 417410 AF063020 Hs. 82110 PG4andSFRS1interactingpMtein1 2. 3 2. 0 450747 Al064821 Hs. 48306 ESTs, Highly similar to EWS_HUMAN RNA-BI 2. 3 3. 8 433680 A1805366 Hs. 199945 ESTs 2. 3 6. 7 420025 AF184939 Hs. 94392 LDL induced EC protein 2. 3 2. 4 413407 A1356293 Hs. 75339 inositol polyphosphate phosphatase-like Z3 3. 1 452908 AB001451 Hs. 30965 neuron She adaptor homolog 2. 3 3. 0 424414 AI361002 Hs. 94814 Homo sapiens cDNA FLJ12168 fis, clone MA 2. 3 2. 0 435791 AA243086 Hs. 25204 chondroitin 4-0-sulfotransferase 2 2. 3 2. 4 457635 AV660976 Hs. 3569 hypothetical protein 2. 3 6. 9 427985 Api770170 Hs. 65583 ESTs 2. 3 Z3 445498 AV654019 Hs. 180402 Homo sapiens cDNA : FW23506 fis, done L 2. 3 2. 3 410310 J02931 Hs. 62192 coagulation factor III (thromboplastin, 2. 3 4. 1 450368 AU077158 Hs. 24930 tubulin-specific chaperone a 2. 3 3. 5 444614 R44284 Hs. 2730 heterogeneous nudearribonudeoprotein 2. 3 2. 6 448607 AL042506 Hs. 21599 Homo sapiens cDNA FLJ10107 fis, clone HE 2. 3 2. 8 447975 BE378418 Hs. 127240 ESTs 2. 3 2. 2 429767 AW793022 Hs. 218329 hypothetca ! protein 2. 3 11. 5 408877 M479033 Hs. 130315 ESTs 2. 3 2. 3

448481 W15284 Hs. 74832 ESTs 2. 3 3. 3 452833 BE559681 Hs. 30736 KIAA0124 protein 2. 3 2. 8 421057 T58283 Hs. 42679 ESTs 2. 3 11. 0 408885 C02741 Hs. 48712 hypotheticalprotein FLJ20736 2. 3 4. 6 427615 BE410107 Hs. 179817 CGI-82 protein 2. 3 2. 3 448861 AL049951 Hs. 22370 Homo sapiens mRNA ; cDNA DKFZp56400122 (f 2. 3 6. 3 430154 AW583058 Hs. 234726 serine (orcysteine) proteinaseinhibito 2. 3 34. 6 428494 AA233439 Hs. 184634 hypothetical protein FLJ20005 2. 3 10. 2 422987 AW407887 Hs. 301772 serine/threoninekinase11 (Peutz-Jegher 2. 3 3. 2 408216 AA741038 Hs. 6670 ESTs 2. 3 3. 3 407862 BE548267 Hs. 50724 Homo sapiens cDNA FU10934 fis, clone OV 2. 3 5. 7 432215 AU076609 Hs. 2934 ribonucleotide reductase M1 polypeptide 2. 3 2. 1 410086 AI268405 Hs. 13467 Homo sapiens BAC clone RP1 1-121A8 from 7 2. 3 2. 2 444853 AW576245 Hs. 149740 HomosapiensmRNAforFW00028protein, 2. 3 4. 5 413284 AU077055 Hs. 289107 baculoviral IAP repeat-containing 2 2. 3 4. 8 445547 D86181 Hs. 273 galactosylceramidase (Krabbedisease) 2. 3 2. 5 420258 AA477514 Hs. 96247 translin-associated factor X 2. 3 3. 5 437223 C15105 Hs. 107884 ESTs 2. 3 2. 7 437353 AA749195 Hs. 143746 ESTs 2. 3 2. 6 426224 BE085860 Hs. 168075 karyopherin (importin) beta2 2. 3 36. 1 402575 Z23024 Hs. 138860 RhoGTPase activating protein 1 2. 3 3. 1 430712 AW044647 Hs. 196284 ESTs 2. 3 2. 4 452036 NM_003966 Hs. 27621 sema domain, seven thrombospondin repeat. 2. 3 2. 4 425180 U00115 Hs. 155024 B-cettCLLllymphoma6 (zincfingerprote 2. 3 4. 3 441648 H05734 Hs. 30559 ESTs 2. 3 2. 1 424130 AL050136 Hs. 140945 Homo sapiens mRNA ; cDNADKFZp586L141 (fr 2. 3 2. 9 414682 AL021154 Hs. 76884 inhibitorofDNAbinding3, dominantneg 2. 3 12. 2 423814 AF105020 Hs. 132989 putative protein 0-mannosyltransferase 2. 3 3. 7 421641 A1638184 Hs. 106334 Homo sapiens clone 23836 mRNA sequence 2. 3 2. 3 427882 AA640987 Hs. 193767 ESTs 2. 3 10. 2 442159 AW163390 Hs. 8123 chromoboxhomolog3 (DrosophilaHP1gamm 2. 3 4. 4 412541 BE009398 Hs. 74002 nuclear receptor coacGvatorl 2. 3 2. 4 447217 BE465754 Hs. 17778 neuropilin 2 2. 3 3. 0 452336 AA960961 Hs. 29147 hypothetical protein FLJ11015 2. 3 4. 1 423913 NM 016436 Hs. 301055 hepatocellularcarcinoma-associatedanG 2. 3 3. 4 411737 AW160339 Hs. 71791 hypothetical protein 2. 2 2. 0 412276 BE262621 Hs. 73798 macrophage migration inhibitory factor 2. 2 2. 4 456974 M12529 Hs. 169401 apolipoprotein E Z2 2. 6 416033 NM012201 Hs. 78979 Golgi apparatus protein 1 2. 2 10. 4 406739 Api566709 Hs. 182426 dbosomal protein S2 2. 2 115. 3 448646 AU077149 Hs. 21704 transcription factor 12 (HTF4, helix-loo 2. 2 4. 2 437371 AK000868 Hs. 5570 hypothetical protein FLJ10006 2. 2 3. 6 451413 AA448974 Hs. 26367 PC3-96 protein 2. 2 6. 2 408665 T88845 Hs. 112200 ESTs, Weakly similar to ALU7 HUMAN ALU S 2. 2 3. 2 437548 A1701596 Hs. 121592 ESTs 2. 2 3. 0 452053 A1750575 Hs. 173933 nuclearfactorl/A 2. 2 3. 3 428303 AW974476 Hs. 183601 regulator of G-protein signalling 16 2. 2 3. 4 441376 H94227 Hs. 6592 ESTs, Weakly similar to salivary proline 2. 2 2. 5 413399 BE091833 gb : iL2-BT0731-260400-076-F04 BT0731 Homo 2. 2 2. 1 448913 AA194422 Hs. 22564 myosin Vl 2. 2 2. 4 439053 BE244588 Hs. 6456 chaperonin containing TCP1, subunit 2 (b 2. 2 3. 1 428065 A1634046 Hs. 157313 ESTs 2. 2 3. 5 425846 AA102174 Hs. 159629 myosinIXB 2. 2 7. 1 426404 AA377607 Hs. 273138 ESTs 2. 2 3. 3 423464 NM016240 Hs. 128856 CSR1 protein 2. 2 2. 1 436135 D85390 Hs. 5057 carboxypeptidase D 2. 2 9. 1 450476 AL045285 Hs. 246849 ESTs, Moderately similar to ALU6_HUMAN A 2. 2 2. 5 420798 W93774 Hs. 99936 keratin 10 (epidermolyfic hyperkeratosis 2. 2 2, 8 433530 BE349534 Hs. 281789 ESTs 2. 2 2, 1 436297 A1084582 Hs. 5105 hypotheticalprotein FLJ10569 2. 2 2. 4 433058 H86865 Hs. 280666 Homo sapiens chromosome 19, cosmid R3218 2. 2 2. 3 435924 AW029203 Hs. 191952 ESTs 2. 2 3. 2 417125 AW181998 Hs. 81248 CUG triplet repeat, RNA-binding protein 2. 2 2. 3 449338 H73444 Hs. 394 adrenomedullin 2, 2 18. 3 446065 AA085191 Hs. 6949 ESTs, Weakly similar to T2D3_HUMAN TRANS 2. 2 3. 1 410668 BE379794 Hs. 65403 hypothetical protein 2. 2 2. 5 424992 AW290893 Hs. 96918 Homo sapiens cDNA : FLJ21561 fis, clone C 2. 2 10. 8 437801 AA613866 Hs. 5848 Homo sapiens mRNA ; cDNA DKFZp564L222 (fr 2. 2 2. 5 412491 W31589 Hs. 73957 RABSA, member RAS oncogene family 2. 2 2. 4 446392 AF142419 Hs. 15020 homotogofmousequakingQK ! (KHdomån 2. 2 3. 4 450503 R35917 Hs. 25042 Homo sapiens mRNA full length insert cDN 2. 2 2. 8 432476 T94344 gb : ye31h10. s1 Stratagenelung (937210) H 2. 2 2. 6 424251 AA677466 Hs. 143696 coactivator-associatedargininemethyttr 2. 2 5. 0 456619 AV647917 Hs. 107153 inhibitor of growth family, member 1-lik 2. 2 2. 6 433411 A1658666 Hs. 49994 ESTs 2. 2 2. 1 424714 At114630 Hs. 208334 Homo sapiens cDNA : FLJ21874 fis, clone H 2. 2 2. 7 416326 AF186780 Hs. 79219 RaIGDS-like gene ; KIAA0959 protein 2. 2 2. 2 407696 AI697340 Hs. 76549 ATPase, Na+/KI transporting, atpha 1 pol Z2 6. 5 445939 BE018658 Hs. 141003 HomosapienscDNA Fw21691fiscRonec 2. 2 4. 4 414765 X07854 Hs. 77269 guanine nucleotide binding protein (G pr 2. 2 6. 2 407136 T64896 Hs. 287420 HomosapienscDNAFW11533fis, ctoneHE 2. 2 2. 8 453665 AA626250 Hs. 181165 eukaryouc translation elongation factor 2. 2 2. 3 433608 AW340005 Hs. 164485 ESTs 2. 2 2. 1

447646 BE619752 Hs. 66053 ESTs, Weakly similar to S22126 finger pr 2. 2 4. 1 433139 AB029826 Hs. 47649 3-methylcstonyl-CoAcarboxylasebioUn-2. 2 11. 7 413433 NM_003199 Hs. 289068 transcription factor 4 2. 2 2. 2 421535 AB002359 Hs. 105478 phosphoribosylfommy ! glycinamidinesyntha 2. 2 2. 2 428591 BE313029 Hs. 185807 Homo sapiens clone 24758 mRNA sequence 2. 2 4. 8 417248 AA329449 Hs. 247302 twisted gastrulation 2. 2 2. 5 403966 2. 2 5. 2 437112 AA744692 Hs. 166539 ESTs 2. 2 3. 0 414799 Ai752416 Hs. 77326 insulin-like growth factor binding prote 2. 2 4. 9 431049 AA846576 Hs. 103267 hypothetical protein FLJ22548 similar to 2. 2 4. 4 422100 Api096988 Hs. 111554 ADP-ribosylafonfactor-like7 2. 2 2. 5 426543 AV650198 Hs. 170311 heterogeneous nuclear ibonucleoprotein 2. 2 2. 4 423720 AL044191 Hs. 23388 Homo sapiens cDNA : FLJ21310 fis, clone C 2. 2 4. 2 443804 AL135352 Hs. 255883 ESTs 2. 2 2. 2 435080 A1831760 Hs. 155111 ESTs 2. 2 2. 5 452808 AF244135 Hs. 30670 hepatocellular carcinoma-associated anti 2. 2 7. 1 433934 AW273261 Hs. 216292 ESTs 2. 2 2. 1 432004 BE018302 Hs. 2894 placentaigrowth factor, vascularendoth 2. 2 4. 4 452518 AA280722 Hs. 24758 ESTs 2. 2 3. 0 409600 AJ011679 Hs. 55099 Homo sapiens mRNA ; cDNA DKFZp586D2123 (f 2. 2 2. 3 448965 AF092134 Hs. 22679 CGI-24 protein 2. 2 4. 0 444954 AW247076 Hs. 12163 eukaryotic translation initiation factor 2. 2 5. 3 458894 AW292171 Hs. 23978 scaffold attachment factor B 2. 2 2. 5 402269 2. 2 2. 2 423798 AF047033 Hs. 301617 HomosapiensmRNAfulilengthinsertcDN 2. 2 4. 0 413836 W92003 Hs. 70614 ESTs 2. 2 3. 6 432231 AA339977 Hs. 274127 CLST 11240 protein 2. 1 2. 1 412204 A1125507 Hs. 130829 ESTs 2. 1 3. 0 438807 AA848011 Hs. 124570 ESTs, Weakiy similar to reverse transcri 2. 1 2. 2 404170 2. 1 41. 6 434858 AW979012 Hs. 134462 ESTs 2. 1 2. 2 426982 AA149707 Hs. 173091 ubiquitin-like 3 2. 1 2. 1 421939 BE169531 Hs. 109727 TAK1-binding protein 2 ; KIAA0733 protein 2. 1 26. 5 442432 BE093589 Hs. 38178 Homo sapiens cDNA : FLJ23468 fis, clone H 2. 1 3. 7 424950 AA602917 Hs. 156974 ESTs 2. 1 19. 9 418123 AA669830 Hs. 83530 hypothetical protein 2. 1 4. 6 440467 AK001519 Hs. 7194 CGi-74 protein 2. 1 5. 3 437092 AA744292 Hs. 181244 majorhistocompatibilitycomplex, class 2. 1 3. 0 421579 NM002975 Hs. 105927 stem cell growth factor, lymphocyte secr 2. 1 3. 3 428953 AA306610 Hs. 194676 DKFZP434C013 protein 2. 1 5. 0 457313 AF047002 Hs. 241520 transcriptional coacuvator 2. 1 3. 5 420570 A1453665 Hs. 290870 ESTs, Weakly similar to S23650 retroviru 2. 1 2. 1 446918 AL135125 Hs. 13913 KIAA1577 protein 2. 1 2. 3 427567 N24236 Hs. 179662 nucteosome assembly protein 1-like 1 2. 1 2. 8 446363 AL117440 Hs. 301967 HomosapiensmRNA ; cDNADKFZp434M196 (fr 2. 1 4. 0 428482 A1290352 Hs. 184592 KIAA0344 gene product 2. 1 2. 8 456559 A1336273 Hs. 102548 glucocoricoid receptor DNA binding fact 2. 1 2. 3 442819 BE622721 Hs. 301766 ESTs, WeaklysimilartohypotheEcatpno 2. 1 27. 1 428808 AA436007 Hs. 188780 ESTs 2. 1 5. 0 414893 AA215295 Hs. 77578 ubiquiNnspecificp » tease9, Xchromos 2. 1 15. 9 447023 AA356764 Hs. 17109 integral membrane protein 2A 2. 1 3. 0 402250 AV655272 Hs. 20252 novel Ras family protein 2. 1 4. 2 429952 AF080158 Hs. 226573 inhibitor of kappa light polypeptide gen 2, 1 7. 9 420006 H14429 Hs. 94300 serologically defined colon cancer antig 2. 1 5. 6 407316 AA031663 Hs. 28802 centaurin-alpha 2 protein 2. 1 4. 4 417139 M69043 Hs. 81328 nuclear factor of kappa light polypeptid 2. 1 103. 2 414774 X02419 Hs. 77274 plasminogen activator, urokinase 2. 1 29. 9 430488 D19589 Hs. 4220 ESTs, Moderately similar to tetracycline 2. 1 2. 1 428680 U69199 Hs. 90259 ESTs, Weakly similar to alpha 1 [H. sapie 2. 1 2. 5 448501 AA332316 Hs. 4273 hypothetical protein FLJ13159 2. 1 2. 0 422552 N39729 Hs. 118243 deoxyribonucleasell, lysosomal 2. 1 2. 9 419476 AW953030 Hs. 59425 Homo sapiens cDNA : FLJ23323 fis, clone H 2. 1 3. 1 408681 AW953853 Hs. 292833 ESTs 2. 1 3. 9 417353 AA375752 Hs. 76362 general transcription factor IIA, 2 (12k 2. 1 4. 1 422070 AF149785 Hs. 111126 pituitary tumor-transforming 1 interacti 2. 1 4. 9 442711 AF151073 Hs. 8645 hypothetical protein 2. 1 2. 2 450139 AK001838 Hs. 296323 Homo sapiens cDNA FLJ10976 fis, clone PL 2. 1 7. 4 452897 BE066058 Hs. 269233 ESTs 2. 1 4. 2 409147 A1889208 Hs. 17283 hypothetical protein FU10890 2. 1 4. 5 433028 A1199144 Hs. 283737 AD-017 protein 2. 1 2. 6 407831 BE613377 Hs. 15580 Homo sapiens cDNA : FLJ22276 fis, clone H 2. 1 8. 5 417871 AA521368 Hs. 24252 ESTs 2. 1 2. 9 428754 At521102 Hs. 301374 ESTs, Moderately similar to ALU5_HUMAN A 2. 1 5. 3 430127 AA219498 Hs. 233952 proteasome (prosome, macropain) subunit, 2. 1 4. 3 442622 NM000435 Hs. 8546 Notch (Drosophila) homolog 3 2. 1 8. 5 414242 AA749230 Hs. 22666 ESTs 2. 1 2. 8 433323 AA805132 Hs. 30701 ESTs 2. 1 5. 0 439022 AA356599 Hs. 173904 ESTs 2. 1 6. 4 443357 AW016773 Hs. 75615 apolipoprotein 2. 1 2. 0 449103 T24968 Hs. 23038 HSPC071 protein 2. 1 2. 7 427512 AB018322 Hs. 179507 KIAA0779 protein 2. 1 2. 0 426728 NM 007118 Hs. 171957 triple functional domain (PTPRF interact 2. 1 2. 9 440112 AA099014 Hs. 231029 ESTs 2. 1 2. 3

446920 BE397649 Hs. 31257 Homo sapiens cDNA FLJ13634 fis, clone PL 2. 1 4. 8 428459 D44650 Hs. 184411 gene with multiple splice variants near 2. 1 2. 9 432842 AW674093 Hs. 279525 hypothetical protein PR02605 2. 1 2. 3 438829 AA826926 Hs. 204214 ESTs 2. 1 2. 7 411442 N25956 Hs. 101810 Homo sapiens cDNA FU14232 fis, clone NT 2. 1 2. 2 409423 Api969783 Hs. 43071 ESTs, Weakly similar to AF1519001 CGI-1 2. 1 2. 2 456804 Api421645 Hs. 139851 caveolin 2 2. 1 15. 2 434536 H14486 Hs. 3903 Cdc42 effector protein 4 ; binder of Rho 2. 1 2. 8 447126 AW150632 Hs. 62954 ferritin, heavy potypepUde 1 2. 1 25. 0 442328 A ! 952430 Hs. 265237 ESTs 2. 1 2. 1 444488 AW192879 Hs. 184796 ESTs, WeaklysimilartoPET2_HUMANOLiGO 2. 1 2. 9 438874 H02780 gb : yj4la11. r1 Soares placenta Nb2HP Homo 2. 1 10. 6 412805 AW954569 Hs. 296287 ESTs 2. 1 4. 6 446334 U52427 Hs. 14839 polymerase (RNA) it (DNA directed) polyp 2. 1 2. 3 427201 AB037860 Hs. 173933 nuclearfactorl/A 2. 1 5. 1 436997 AA741151 Hs. 137323 ESTs 2. 1 3. 0 426369 AF134157 Hs. 169487 Kreis) er (mouse) maf-relatedieucineåp 2. 1 2. 3 453613 F06838 Hs. 14763 ESTs 2. 1 2. 4 413276 Z24725 Hs. 75260 mitogen inducible 2 2. 1 5. 5 422050 AA302741 Hs. 25786 ESTs 2. 1 4. 0 424797 AA622394 Hs. 153177 ribosome protein S28 2. 1 2. 1 437365 AW965771 Hs. 91065 hypothetical protein DKFZp761 B2423 2. 1 3. 0 412482 A1499930 Hs. 181043 KIAA0788 protein 2. 1 2. 7 418662 A1801098 Hs. 151500 ESTs 2. 1 2. 1 404030 2. 1 2. 1 437802 A1475995 Hs. 122910 ESTs 2. 1 3. 8 441130 A1160734 Hs. 283429 SMC (mouse) homolog, X chromosome 2. 1 3. 5 416084 L16991 Hs. 79006 deoxythymidylate kinase (thymidylate kin 2. 1 7. 4 409944 BE297925 Hs. 57687 four and a half LIM domains 3 2. 1 6. 3 425421 L11669 Hs. 157145 tetracycline transporter-like protein 2. 1 7. 1 428399 Nom-006276 Hs. 184167 splicing factor, arginine/serine-rich 7 2. 1 2. 7 421313 NM_014923 Hs. 103329 KIAA0970 protein 2. 1 2. 6 445229 BE276013 Hs. 172364 Homo sapiens mRNA for FU00086 protein, 2. 1 4. 7 401001 2. 1 14. 7 425159 NM_004341 Hs. 154868 carbamoyl-phosphate synthetase 2, aspart 2. 1 7. 2 438855 AW946276 Hs. 6441 Ussue inhibitor of metalloproteinase 2 2. 1 4. 9 433369 Z49254 Hs. 3254 mitochondrial ribosomal protein L23 2. 1 25. 0 433228 F28212 Hs. 284247 KIAA1491 protein 2. 1 5. 1 445392 AA057478 Hs. 23272 ESTs 2. 0 2. 3 433891 AA613792 gb : no97hO3. s1 NCt_CGAP_Pr2Homosapiens 2. 0 2. 5 432572 A1660840 Hs. 191202 ESTs, WeaklysimilartoALUE_HUMAN ! ! ! ! 2. 0 2. 9 448474 At792014 Hs. 13809 ESTs 2. 0 12. 1 427045 H86504 Hs. 173328 protein phosphatase 2, regulatory subuni 2. 0 2. 9 444916 AB028956 Hs. 12144 KIAA1033 protein 2. 0 4. 2 439177 AW820275 Hs. 76611 ESTs 2. 0 3. 3 423533 NM 014339 Hs. 129751 interleukin 17receptor 2. 0 5. 0 430057 AW450303 Hs. 2534 bone morphogenetc protein receptor, typ 2. 0 2. 3 424429 U63830 Hs. 146847 TRAF family member-associated NFKB activ 2. 0 12. 7 428385 AF112213 Hs. 184062 putaaveRab5interacEngprotein 2. 0 4. 6 458946 AA009716 Hs. 42311 ESTs 2. 0 16. 4 444816 Z48633 Hs. 283742 H. sapiens mRNA for retrotransposon 2. 0 4. 9 426829 A1761241 Hs. 301719 ESTs 2. 0 2. 4 433619 AW965275 Hs. 284288 hqp0256 protein 2. 0 4. 4 421985 AK001779 Hs. 110445 CGI-97 protein 2. 0 3. 8 439895 AB037773 Hs. 6762 hypothetical protein FLJ10595 2. 0 2. 2 449188 AW072939 Hs. 23200 myotubularin related protein 1 2. 0 2. 2 404820 2. 0 2. 7 425811 AL039104 Hs. 159557 karyopherin alpha 2 (RAG cohort 1, impor 2. 0 2. 5 422163 AF027208 Hs. 297332 Homo sapiens cDNA : FU21471 fis, clone C 20 3. 7 431172 Al125639 Hs. 250666 hairy (Drosophila)-homolog 2. 0 10. 2 415200 AL040328 Hs. 301912 Homo sapiens cDNA : FLJ22920 fis, clone K 2. 0 2. 1 458176 AI961519 Hs. 140309 ESTs, Weaktysimi ! artoKIM0681 protein 2. 0 5. 0 407895 R44203 Hs. 265540 HSPC042 protein 2. 0 4. 6 449816 A1701457 Hs. 38694 ESTs 2. 0 2. 0 422976 AU076657 Hs. 1600 sec61 homolog 2. 0 5. 7 430220 BE378277 Hs. 152230 ESTs 2. 0 11. 7 435446 AA682305 Hs. 133268 ESTs 2. 0 4. 2 431031 AA830335 Hs. 105273 ESTs 2. 0 14. 1 425233 Z17861 Hs. 155218 E1B-55kDe-associated protein 5 2. 0 5. 6 426458 D83032 Hs. 169984 nuclear protein 2. 0 5. 9 421965 AA301100 gb : EST14128 Testis tumor Homo sapiens cD 2. 0 2. 1 427128 AW301984 Hs. 173685 Homo sapiens CDNA FU 12619 fis, clone NT 2. 0 6. 3 449722 BE280074 Hs. 23960 cyclin B1 2. 0 2. 1 450816 BE271927 Hs. 87385 ESTs 2. 0 2. 4 453507 AF083217 Hs. 33085 WD repeat domain 3 2. 0 13. 1 422801 AF125672 Hs. 287994 nuclear receptor co-repressor 2 2. 0 3. 5 418178 AA043951 Hs. 83715 Sjogren syndrome antigen B (autoantigen 2. 0 3. 9 417819 Al253112 Hs. 133540 ESTs 2. 0 4. 0 414787 AL049332 Hs. 77311 BTG family, member 3 2. 0 4. 0 447032 AK000310 Hs. 17138 hypothetical protein FLJ20303 2. 0 7. 0 431742 NM_016652 Hs. 268281 CGI-201 protein 2. 0 2. 5 448431 BE613061 Hs. 300697 ESTs, Weakly similar to CA13 HUMAN COLLA 2. 0 6. 5 456444 AA884517 Hs. 31856 ESTs, Weakly similar to KIAA1453 protein 2. 0 2. 5

419178 NM 006284 Hs. 89657 TATA box binding protein (TBP)-associate 2. 0 6. 0 446437 AW014360 Hs. 202119 ESTs, WeaklysimilartoA46010X-linked 2. 0 2. 2 449910 A1074585 Hs. 58440 ESTs 2. 0 2. 1 435963 AF271212 Hs. 87627 disrupter of silencing 10 2. 0 2. 1 421283 A1760018 Hs. 205071 ESTs 2. 0 2. 6 414482 S57498 Hs. 76252 endothelin receptor type A 2. 0 2. 4 450960 AB013897 Hs. 25722 Homo sapiens mRNA for HKR1, partial cds 2. 0 2. 1 438644 Api126162 Hs. 129037 ESTs 2. 0 2. 1 458343 A1004775 Hs. 205091 ESTs, Weakly similar to WW domain bindin 2. 0 6. 5 412574 BE410731 Hs. 74050 foiiicuiariymphomavarianttransiocaho 2. 0 12. 4 458079 Api796870 Hs. 54277 ESTs 2. 0 3. 8 450582 Al339732 Hs. 13144 HSPC160 protein 2. 0 2. 8 409936 AK001691 Hs. 57655 hypothetical protein FLJ10829 2. 0 3. 1 426865 D63476 Hs. 172813 PAK-interacting exchange factor beta 2. 0 3. 3 446430 AA346837 Hs. 15075 hypothetical protein DKFZp434E2216 2. 0 2. 0 Table 4B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 447197 2176805_1 R36075 R36167 Al366546 407192 22002021 AA602964 AA609200 429007 327976 1 AA443145 BF958169 AW904500 AL119015 D80642 429163 12382971 AW974271AA592975AA447312AA884766 439579 24302_1 AF086400 W73990 W79232 432060 1235850-1 AA525021 AW971364 AA570759 416913 924456 1 AW934714 AW749864 AW749902 BE162498 BE161005 BE162499 BE161006 AA190449 AW513465 BE162500 BE161007 426413 372468_1 AW954494M377823 BG219617 BG195685 BG616269Ai022688 433586 32908J 8C011194AW517087AA601054T85512 448451 7632_32 AW000978 R39898 AW015994 Ai598202 BF821479 Al521706 442495 928718 1 Ai184717AW518883AF121173 439566 23928 1 AF086387W72711W77884 407939 600387_1 AW118352AW196215W05608 453740 612139 1 AL120295BG291384T88779 433854 899720 1 BG675161 H59558AI699484M610649A1937812 413020 1485885_1 BE048113 R98736 Z42904 458050 61684 1 AK057874 AW901381 AW901380 AV730240 T50211 AA828756 AA834708 440769 214305 BG419454 BF924037 R13764 AW793200 BE561793 BG698295 BE270077 428832 1137866 1 81008687 AA481363 AA436432 B1008686 AA578229 AA481375 414473 357613 BG392866BE302693 422343 786037 1 AW961833 AA309282 AA551780 A1628633 AA551995 AW378461 431319 122030 1 BG435498 BG924768 AV718636 AA873350 T82428 T82429 AU185416 AA658442 422221 319 18 BG910399 BE826714 BF905312 AA306649 Z40822 N76633 413399 1511159 1 BE091833 BE091874 BE091871 432476 1237465 1 AW973269 AA548913 T94344 AA834800 AA857492 438874 52147_1 AF075017 R66779 R22463 H02780 433891 647290 1 AW182329 AA613792 T05304 AW858385 421965 1883 13 BC022394 A1742351 BE676249 At742341 AW572776 AJ566256 At538553 B1837905 AA301100 AA620903 Ah42397 AW082310 A1147387 BF509145 AW968207 AA468415 AU185163 AW450843 Ai568752 AW137191 TABLE 4C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al."refers to the publication entitled"The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ni positon 400859 9757499 Minus 91888-92018, 98131-98294, 99474-99570 405238 7249119 Minus 51728-51836 400992 8096828 Plus 140390-140822 400860 9757499 Minus 151830-152104, 152649-152744 402524 9798518 Minus 20529-21096 404210 5006246 Plus 169926-170121 402604 9909420 Plus 20393-20767 402855 9662953 Minus 59763-59909 404029 7671252 Plus 108716-111112 402605 9909420 Minus 47680-47973 404049 3688074 Minus 75765-78155 403549 8081591 Minus 137150-137362 404048 3688074 Minus 54421-56808 404171 9930793 Plus 173667-173783, 176876-177055 405649 4926908 Minus 50032-50132, 50624-50764 405268 4156151 Minus 24404-24521 405204 7230116 Plus 126569-126754 405517 9454624 Plus 114757-114877 405203 7230116 Plus 125295-125463 405687 6249668 Minus 54787-54891, 55844-55917 403966 8568881 Plus 158193-158277, 160116-160290 402269 3128156 Minus 1168-1324, 5492-5611, 23445-23851 404170 9930793 Plus 168836-169248

404030 7671252 Plus 149362-151749 401001 7229886 Minus 113631-113762 404820 4678240 Plus 20475-21085 TABLE 5A : ABOU"T 43 GENES UPREGULATED IN GLIOBLASTOMA THAT ENCODE PREDICTED MEMBRANE PROTEINS Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number Unigene ! D : Unigene number Unigene Title : Unigenegenetitie R1 : Ratio of brain tumor to body allas R2 : Ratio of brain tumor to normal brain Pkey ExAccn UnigenelD Unigene title R1 R2 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 72, 0 11. 3 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 54. 2 7. 1 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 22. 0 7. 6 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 21. 2 3. 0 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) 18. 6 18. 6 417355 D13168 Hs. 82002 endothelin receptor type B 16. 4 16. 4 419721 Nu-001650 Hs. 288650 aquaporin 4 16. 2 4. 4 452355 N54926 Hs. 29202 G protein-coupled receptor 34 13. 9 13. 9 410227 AB009284 Hs. 61152 exostoses (multiple)-like 2-11. 9 2. 9 419723 AL120193 Hs. 92614 Homo sapiens growth differentiation fact 7. 4 3. 5 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 6. 9 6. 4 443898 AW804296 Hs. 9950 Sec61 gamma 4. 8 7. 2 422033 AW245805 Hs. 110903 claudin 5 (transmembrane protein deleted 4. 3 6. 1 414821 M63835 Hs. 77424. FcfragmentofigG, highaHnityla, re 4. 2 34. 8 431556 AF016028 Hs. 260039 sarcospan (Kras oncogene-associated gene 4. 0 3. 8 435869 AF255910 Hs. 54650 vascularendothelialjunction-associated 3. 7 4. 2 440516 S42303 Hs. 161 cadherin 2, type 1, N-cadherin (neuronal 3. 5 5. 1 428141 D50402 Hs. 182611 solutecanierfamily 11 (proton-coupled 3. 5 2. 4 428484 AF104032 Hs. 184601 sdutecarrierfamity7 (caEonicamino 3. 4 2. 8 431053 S40369 Hs. 249141 Glutamate receptor subunit 3. 3 2. 4 445070 NM_000677 Hs. 258 adenosine A3 receptor 3. 2 7. 6 430890 X54232 Hs. 2699 glypican 1 3. 2 4. 3 423422 AC005175 Hs. 128425 NY-REN-24 antigen 3. 2 4. 0 413367 NM006517 Hs. 75317 solute carder family 16 (monocarboxylic 3. 1 2. 6 447471 AF039843 Hs. 18676 sprouty (Drosophila) homolog 2 3. 0 4. 1 427150 BE616183 Hs. 173737 ras-related C3 botutinum toxin substrate 3. 0 4. 1 422676 D28481 Hs. 1570 histamine receptor H1 3. 0 2. 1 430293 Api416988 Hs. 238272 inositol 1, 4, 5-triphosphate receptor, ty 3. 0 6. 3 453496 AA442103 Hs. 33084 solute carrier family 2 (facilitated glu 2. 8 7. 4 428281 AA194554 Hs. 183434 ATPase, H+transporting, lysosomal (vacu 2. 7 3. 2 417446 AL118671 Hs. 82163 monoamine oxidase B 2. 4 4. 4 412676 NM 000165 Hs. 74471 gap junction protein, alpha 1, 43kD (con 2. 4 2. 2 440225 BE295782 Hs. 159 tumor necrosis factor receptor superfami 2. 4 76. 7 450447 AF212223 Hs. 25010 hypothetical protein P15-2 2. 3 2. 3 410310 J02931 Hs. 62192 coagulation factor III (thrombopiastin, 2. 3 4. 1 452036 NM003966 Hs. 27621 sema domain, seven thrombospondin repeat 2. 3 2. 4 447217 BE465754 Hs. 17778 neuropilin 2 2. 3 3. 0 447023 AA356764 Hs. 17109 integral membrane protein 2A 2. 1 3. 0 422070 AF149785 Hs. 111126 pituitary tumor-transforming 1 interacti 2. 1 4. 9 456804 Ai421645 Hs. 139851 caveolin 2 2. 1 15. 2 430057 AW450303 Hs. 2534 bone morphogenetic protein receptor, typ 2. 0 2. 3 422163 AF027208 Hs. 297332 Homo sapiens cDNA : FLJ21471 fis, clone C 2. 0 3. 7 414482 S57498 Hs. 76252 endothelin receptor type A 2. 0 2. 4 TABLE 6A : ABOUT 397 GENES DOWNREGULATED IN GLIOBLASTOMA Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of normal brain to body atlas R2 : Ratio of normal brain to brain tumor Pkey ExAccn UnigenelD Title R1 R2 439340 AB032436 Hs. 6535 brain-specific Na-dependent inorganic ph 4. 47 77. 82 424846 AU077324 Hs. 1832 neuropeptide Y 4. 49 55. 32 428874 W32133 Hs. 194366 transthyretin (prealbumin, amyloidosis t 7. 06 45. 64 416836 D54745 Hs. 80247 cholecystokinin 9. 45 44. 59 401412 c14p3_2958 exon 3. 20 32. 56 451835 T63643 Hs. 209715 ESTs, Weakly similar to ALU7_HUMAN ALU S 3. 21 28. 93 412768 AW996044 Hs. 26239 ESTs 3. 16 28. 12 415448 T68645 Hs. 952 solutecarrierfamily10 (sodium/biteac 3. 27 27. 04 411305 BE241596 Hs. 69547 myeTin basic protein 13. 80 25. 92 438054 AA776626 Hs. 62183 ESTs 3. 59 25. 06 410837 BE145698 gb : LO-HT0205-231199-145-a07HT0205Homo 3. 05 24. 43 425121 A1797511 Hs. 154679 synaptotagmin 1 6. 92 23. 67 456763 AJ271351 Hs. 128180 B-celltranslocationgene4 3. 29 23. 32 429656 X05608 Hs. 211584 neurofilament, light polypepude (68kD) 8. 03 22. 56 451892 A1821302 Hs. 167834 ESTs 4. 12 21. 82

424922 BE386547 Hs. 2171 12 ESTs, Weakly similar to Similarity to Ye 4. 41 21. 28 411666 AF106564 Hs. 71346 neurofilament3 (150kD medium) 5. 27 21. 20 432247 AA531287 Hs. 105805 ESTs 3. 25 21. 14 436812 AW298067 gb : UI-H-BW0-ajp-g-09-0-Ut. s1 NCl_CGAP_Su 3. 02 21. 12 422234 AF119818 Hs. 113287 discs, large (Drosophila) homolog-associ 3. 38 20. 50 435708 A1362949 Hs. 75169 ESTs 8. 79 20A5 423135 N67655 Hs. 26411 ESTs 6. 82 20. 28 440600 A1807691 Hs. 126351 ESTs 3. 56 20. 09 405230 cNp1J656 exon 3. 31 19. 95 456915 N55540 Hs. 78026 ESTs, Weakly similar to similar to ankyr 3. 14 19. 40 425130 AA448208 Hs. 99163 ESTs 3. 53 19. 20 416812 H91010 Hs. 44940 ESTs 3. 54 19. 08 454171 AW854832 gb : QV2-CT0261-201099-011-f05CT0261Homo 3. 78 19. 04 457463 AW877031 Hs. 272321 Homo sapiens cDNA FLJ12571 fis, clone NT 3. 13 18. 91 454589 AW809699 gb : MR4-ST0124-241199-026-e12ST0124Homo 4. 10 18. 60 418104 T05726 Hs. 177130 ESTs 3. 17 18. 41 416357 T82050 Hs. 268907 ESTs 3. 11 18. 13 414683 S78296 Hs. 76888 internexin neuronal intermediate filamen 5. 55 18. 13 447694 At420083 Hs. 170303 ESTs 3. 56 17. 79 427627 R87582 Hs. 179915 guanine nucleotide binding protein (G pr 4. 63 17. 65 428010 AA806554 Hs. 185375 ESTs 3. 03 17. 40 417159 R01761 gb : ye81f10. s1 Soaresfetalliverspleen 3. 23 17. 38 436788 AA766908 Hs. 259047 ESTs 3. 16 17. 21 459349 AW749381 gb : QV3-BT0381-170100-060-cO2 BT0381 Homo 3. 26 17. 10 450214 BE439763 Hs. 227571 regulator of G-protein signalling 4 3. 86 17. 04 438068 Api927209 Hs. 283089 HMT1 (hnRNP methyltransferase, S. cerevi 3. 54 16. 48 437268 At754847 Hs. 227571 regulator of G-protein signalling 4 5. 63 16. 32 435315 AA700240 Hs. 165402 ESTs 4. 06 16. 12 424240 AB023185 Hs. 143535 calcium/calmodulin-dependent protein kin 4. 69 15. 92 412446 Al768015 Hs. 92127 ESTs 5. 44 15. 75 449714 AB033015 Hs. 23941 MAA1189 protein 4. 59 15. 43 435832 AA425688 Hs. 41641 Bruno (Drosophila)-like 4, RNA binding 4. 63 14. 97 437397 AA349847 Hs. 4221 hypotheticalprotein DKFZp761H039 5. 93 14. 81 435502 L13266 Hs. 105 glutamate receptor, ionotropic, N-methyl 3. 29 14. 61 414187 BE312141 gb : 601145962F1NtH MGC 19Homosapiensc 3. 37 14. 46 417868 A1078534 Hs. 122592 ESTs 7. 57 14. 22 428536 Ai143139 Hs. 2288 visinin-like 1 5. 16 13. 98 402125 c18p3_155 exon 3. 11 13. 94 440503 NM006539 Hs. 7235 calcium channel, voltage-dependent, gamm 3. 49 13. 92 419090 T85201 Hs. 188468 ESTs 3. 25 13. 79 437665 AA765417 Hs. 292053 ESTs 3. 07 13. 79 457113 A1734016 Hs. 270508 ESTs 3. 50 13. 69 424933 AW999974 Hs. 5181 proliferation-associated 2G4, 38kD 3. 59 13. 48 443489 Ai073512 Hs. 133916 ESTs 3. 24 13. 20 404289 c6p3 5821 exon 3. 99 13. 12 406534 ph2_4616 exon 3. 89 13. 10 423280 AA324037 gb : EST26901 Cerebellum 11 Homo sapiens c 3. 38 13. 03 455421 AW937661 Hs. 288324 Homo sapiens DNA FLJ13283 fis, clone OV 3. 04 12. 93 433725 AF063559 Hs. 283919 HomosapiensctoneHQ0117PRO0117mRNA, 3. 71 12. 85 416660 R98905 Hs. 35992 ESTs 3. 92 12. 74 407593 AW044083 Hs. 237008 ESTs 3. 85 12. 67 451734 NM 006176 Hs. 26944 neurogranin (protein kinase C substrate, 7. 41 12. 59 410366 A1267589 Hs. 25214 hypothetical protein 7. 89 12. 50 405348 cNp3_13716 exon 3. 45 12. 42 442338 Ai761976 Hs. 156080 ESTs 3. 69 12. 35 424458 M29273 Hs. 1780 myelin associated glycoprotein 4. 72 12. 31 431400 AA504607 gb : aa63a02. s1 NCI_CGAP_GCB1 Homosapiens 3. 42 12. 29 417754 R13027 Hs. 268703 ESTs 3. 35 12. 18 440184 AB002297 Hs. 7022 dedicatorofcyto-kinesis3 6. 15 12. 11 431339 AA506294 Hs. 257266 ESTs 3. 50 11. 97 452265 BE501516 Hs. 114772 ESTs 3. 82 11. 96 419297 AA446040 Hs. 98640 HomosapienscDNA : FLJ21069 fis, clone C 3. 16 11. 86 424991 AA775471 Hs. 241467 ESTs 3. 03 11. 64 431988 AC002302 Hs. 77202 protein kinase C, beta 1 3. 78 11. 62 450987 AA017202 Hs. 32794 ESTs 3. 28 11. 61 440607 AA894559 Hs. 192097 ESTs 3. 11 11. 60 454566 AW807605 gb : MR4-ST0098-120100-001-b06ST0098Homo 3. 26 11. 54 442000 H38671 Hs. 8071 KIAA0735 gene product ; synaptic vesicle 3. 44 11. 51 437948 AA772920 gb : ae73cO9. s1StratageneschizobrainS1 3. 16 11. 46 401081 c11p3 921 exon 3. 18 11. 35 438919 AW979114 gb : EST391224 MAGE resequences, MAGP Homo 4. 16 11. 35 454578 AW809178 gb : MR4-ST0118-261099-012cO7ST0118Homo 3. 02 11. 27 422279 H69644 Hs. 114231 Gtype lectin-like receptor-2 3. 35 11. 13 453101 AW952776 Hs. 94943 ESTs 3. 21 11. 07 455836 BE145795 gb : MRO-HT0208-101299-103-a12 HT020 Homo 3. 61 10. 83 413324 V00571 Hs. 75294 corticotropin releasing hormone 3. 72 10. 71 412266 N59006 Hs. 26133 ESTs 3. 80 10. 60 436887 AW953157 Hs. 193235 ESTs 7. 24 10. 56 454968 AW849046 gb : IL3-CT0214-150300-085-H06 CT0214 Homo 3. 05 10. 53 418162 T11958 gbA802R Heart Homo sapiens cDNA clone A 3. 07 10. 50 425537 AB007913 Hs. 158291 KIAA0444 protein 3. 07 10. 46 436230 A1248723 Hs. 17711 ESTs 3. 09 10. 45 431169 AW971240 gb : EST383329 MAGE resequences, MAGL Homo 3. 02 10. 43

447359 NM012093 Hs. 18268 adenylate kinase 5 5. 91 10. 40 457187 AA443927 Hs. 144360 EST 3. 30 10. 39 407539 X91103 gb : H. sapiensmRNAforHr44protein. 3. 02 10. 35 452855 R17746 Hs. 84469 ESTs 3. 02 10. 26 440352 A1692322 Hs. 65373 ESTs 3. 03 10. 20 456116 Z28528 Hs. 172004 titin 3. 11 10. 17 458172 BE007237 gb : PMO-BN0139-050500-003-g09 BN0139 Homo 3. 32 10. 14 445881 A1263029 Hs. 210689 ESTs 3. 04 10. 11 454059 NM_003154 Hs. 37048 statherin 3. 27 9. 97 402624 c1p12660 exon 3. 05 9. 94 441539 AA937200 Hs. 192939 ESTs 3. 27 9. 82 412172 N76794 gb : yv45gO7. r1 Soaresfetalliverspleen 3. 03 9. 78 427942 AA417856 gb : zv01d05. r1 NCI_CGAP_GCB1 Homo sapiens 4. 09 9. 73 436867 BE041837 Hs. 120316 ESTs 3. 25 9. 73 454688 AW814472 gb : MR3-ST0203-010200-109-bO6 ST0203 Homo 3. 41 9. 73 446122 A1362790 Hs. 181801 ESTs 3. 40 9. 71 420480 AL137361 Hs. 98173 hypothetical protein 3. 03 9. 56 433447 U29195 Hs. 3281 neuronal pentraxin 11 3. 72 9. 54 407178 AA195651 Hs. 104106 ESTs 3. 89 9. 47 415614 F12926 Hs. 165998 DKFZP564M2423protein 3. 06 9. 45 450518 BE245175 Hs. 270893 ESTs 3. 99 9. 39 455675 BE065984 gb : RC3-BT0319-120200-014-aO6 BT0319 Homo 3. 46 9. 32 456459 AA253074 Hs. 146261 ESTs 4. 08 9. 30 423420 A1571364 Hs. 128382 Homo sapiens MRNA ; EDNA DKFZp76111224 (f 5. 18 9. 23 455644 BE064521 gb : RC4-BT0311-250200-014dO2BT0311 Homo 3. 02 9. 20 419800 AA282392 Hs. 191525 ESTs 3. 28 9. 16 430964 Y10929 Hs. 248167 zinc finger protein 186 (Kruppel type) 3. 04 9. 00 409716 AL117454 Hs. 56027 HomosapiensmRNA ; cDNA DKFZp586J 1717 (f 3. 02 9. 00 412962 AW839578 Hs. 18160 Homo sapiens CDNA FLJL 1550 fis, clone HE 3. 33 8. 99 445040 AW444934 Hs. 195929 ESTs, Weakiy similar to pre-serumamytoi 3. 50 8. 96 451496 AW503407 gb : Ut-HF-BNO akw-d-11-0-Ul. r1 NIH_MGC_50 3. 17 8. 94 424617 AA344151 gb : EST50059 Gall bladder I Homo sapiens 3. 25 8. 91 441914 AA971496 Hs. 128465 ESTs 3. 42 8. 88 405320 cNp3_12168 exon 3. 30 8. 84 449179 A1633785 Hs. 196561 ESTs 3. 43 8. 84 400335 Y13187 Hs. 248066 Homo sapiens dmd gene, intron 11 3. 13 8. 78 454962 AW847645 gb : iL3-CT0213-280100-056-A04CT0213Homo 4. 16 8. 74 407803 AW081681 Hs. 269064 ESTs 3. 09 8. 73 455260 AW878317 gb : MR3-OT0007-260300-206-eO9 OT0007 Homo 3. 78 8. 70 431096 AA324358 Hs. 249227 Homo sapiens DNA, cosmid clones TN62 and 4. 01 8. 67 424481 R19453 Hs. 1787 proteolipid protein (Pelizaeus-Merzbache 8. 12 8. 63 407616 AW054849 Hs. 246831 ESTs, Weakly similar to CIKG_HUMAN VOLTA 3. 08 8. 53 434589 AF147363 gb : HomosapiensfulllengthinsertcDNA 3. 26 8. 51 439239 A1031540 Hs. 235331 ESTs 5. 78 8. 48 410926 AW810708 gb : MR2-ST0129-051099-007-g07ST0129Homo 3. 34 8. 47 430004 U27768 Hs. 227571 regulator of G-protein signalling 4 4. 26 8. 45 409623 AW449185 gb : UI-H-BI3-akg-e-05-0-Ul. s1 NCI_CGAP Su 3. 32 8. 43 420156 AW449258 Hs. 6187 ESTs 3. 40 8. 38 411555 AF113537 Hs. 70669 HMP19 protein 5. 85 8. 34 408509 AA497035 Hs. 110502 ESTs 3. 17 8. 34 442368 A1698577 Hs. 202481 ESTs 3. 02 8. 33 457870 AA732217 Hs. 294054 ESTs 3. 04 8. 32 437254 AA831258 gb : oc73fO4. s1 NC ! _CGAP_GCB1 Homo sapiens 3. 35 8. 24 415508 R39236 gb : yc91d03. s1Soaresinfantbrain1NIBH 3. 07 8. 22 409483 U49379 Hs. 54506 diacylglycerot kinase, epsiton (6AkD) 3. 31 8. 20 435229 AA676556 Hs. 269515 ESTs, Moderately similar to ALUB HUMAN ! 3. 21 8. 19 458120 W21398 Hs. 54523 ESTs, Weakly similar to cytochrome P450 3. 22 8. 17 444613 H29627 Hs. 79092 ESTs 3. 78 8. 16 417050 N39540 Hs. 108029 ESTs 4. 06 8. 14 425607 U09860 Hs. 158333 protease, serine, 7 (entemkinase) 3. 68 8. 06 413263 BE075131 gb : PM1-BT0585-110200-003-gO3 BT0585 Homo 3. 40 8. 04 424549 Api873205 Hs. 183114 HomosapienscDNAFLJ14236fis, cloneNT 3. 27 8. 03 452689 F33868 Hs. 284176 transferrin 3. 03 8. 01 405476 cNp3_19940 exon 3. 28 8. 00 403932 c5p1 533 exon 3. 58 7. 99 407095 AF011757 Hs. 105937 RAGE binding protein 3. 32 7. 96 415967 H11124 gb : ym14hO7. s1Soaresinfantbrain1NIBH 3. 10 7. 96 417555 H65366 gb : yr67c10. r1 Soaresfetalliverspleen 3. 05 7. 95 448985 AA324885 Hs. 22777 carbonic anhydrase Xi 5. 30 7. 79 428689 NM_014351 Hs. 189810 sulfotransferase-related protein 3. 87 7. 74 424140 Z48051 Hs. 141308 myelin oligodendrocyte glycoprotein 4. 68 7. 74 441099 AW339393 Hs. 126573 ESTs 3. 08 7. 74 448589 AF017090 Hs. 21554 KIAA1107 protein 3. 10 7. 73 406112 phO_24243 exon 3. 22 7. 70 458439 AV647220 Hs. 282889 ESTs, Weakly similar to strong similar 3. 22 7. 69 429859 NM_007050 Hs. 225952 protein tyrosine phosphatase, receptor t 3. 15 7. 68 412090 AW955826 Hs. 12396 ESTs, Weakly similar to ALU6 HUMAN ALU S 3. 01 7. 67 413547 BE147440 gb : RC1-HT0229-080100-015-f09 HT0229 Homo 3. 01 7. 66 447772 A1924558 Hs. 161399 ESTs 3. 04 7. 63 411132 AW819191 gb : CM1-ST0283-071299-061-dO8 ST0283 Homo 3. 72 7. 61 425490 NM_002248 Hs. 158173 potassium intermediatelsmall conductance 3. 15 7. 60 454568 BE141434 gb : MRO-HT0079-051099-002-dO1 HT0079 Homo 3. 16 7. 59 439099 AB037800 Hs. 6462 KIM1379 protein 3. 40 7. 57

415669 NM005025 Hs. 78589 serine (orcysteine) proteinaseinhibito 5. 71 7. 57 428175 A1810774 Hs. 98376 ESTs 3. 04 7. 55 413162 BE068115 gb : CM1-BT0368-061299-060-gO7BT0368Homo 3. 43 7. 54 451361 AA053854 Hs. 235390 Homo sapiens mRNA ; cDNADKFZp761B101 (fr 3. 11 7. 53 442527 AF150289 Hs. 205436 ESTs 3. 31 7. 53 450407 NM_000810 Hs. 24969 gamma-aminobutyricacid (GABA) Arecepto 5. 24 7. 53 456966 A) 589569 Hs. 190082 ESTs 3. 13 7. 47 441799 AW292276 Hs. 127872 ESTs 3. 38 7. 41 424185 M279752 Hs. 142570 Homo sapiens clone 24629 mRNA sequence 3. 16 7. 40 429783 AA811987 Hs. 125779 ESTs 3. 13 7. 38 429268 AA205386 Hs. 198481 RAR-related orphan receptor B 3. 48 7. 38 400708 c11p1_1292 exon 3. 33 7. 35 402598 BE314624 Hs. 3128 polymerase (RNA) II (DNA directed) polyp 3. 04 7. 33 455377 AW905347 gb : QV2-NN1073-220400-159-f06 NN1073 Homo 3. 03 7. 33 435070 A1821270 Hs. 116930 ESTs 3. 03 7. 33 405427 cNp3_17682 exon 3. 03 7. 25 455149 AW861879 gb : CMO-CT0341-260100-160-h12CT0341 Homo 3. 56 7. 24 402816 c1p3_2531 exon 3. 13 7. 21 422890 Z43784 Hs. 78713 solutecarrierfami@25 (mitochondriat 3. 40 7. 15 422297 AW961290 Hs. 155615 ESTs 3. 44 7. 10 412686 AW984068 gb : RCO-HN0006-160300-011-eO6HN0006Homo 3. 91 7. 09 436383 BE065178 gb : RC1-BT0314-020200-012-h01 BT0314 Homo 3. 09 7. 09 412290 BE069037 gb : QV3BT0379-161299-040-e12BT0379Homo 3. 04 7. 08 415486 H12214 Hs. 13284 ESTs 4. 22 7. 07 407728 AW071502 Hs. 175931 ESTs 3. 05 7. 06 448548 R13209 Hs. 21413 solute carder family 12, (potassium-chl 5. 93 7. 05 417275 X63578 Hs. 81849 parvalbumin 4. 08 7. 04 418425 A1871247 Hs. 6262 ESTs 4. 10 7. 04 440558 AA889574 Hs. 177511 ESTs 3. 28 7. 04 411427 AW846080 gb : MR3CT0176-081099-002-bO9CT0176Homo 3. 11 7. 03 422272 Api452421 Hs. 77965 Clk-associating RS-cyclophilin 3. 39 7. 03 410816 AW806175 gb : MR1-UM0106-130400-003-aO6 UM0108 Homo 3. 30 7. 02 418375 NM 003081 Hs. 84389 synaptosomal-associated protein, 25kD 9. 93 7. 01 421627 A1138551 Hs. 97318 ESTs 3. 10 7. 01 447258 BE047911 gb : tz44aO5. y1 NCI CGAP_Bm52Homosapien 3. 09 6. 99 455547 AW994078 gb : RC3-BN0036-090200-011-h02BN0036Homo 3. 35 6. 98 432209 AW971278 gb : EST383367 MAGE resequences, MAGL Homo 3. 49 6. 92 404541 c8p1_6409 exon 4. 62 6. 89 451539 AA059467 Hs. 218933 ESTs 3. 01 6. 88 429954 At918130 Hs. 21374 ESTs 3. 82 6. 87 411138 AW819500 gb : RC5-ST0293-180100-012-C07ST0293Homo 3. 08 6. 87 447464 AW444957 Hs. 201897 ESTs, Weakly similar to ALU4_HUMAN ALU S 3. 33 6. 85 454713 AW815111 gb : QV4-ST0212-091199-023cO9ST0212Homo 3. 16 6. 84 415734 NM014747 Hs. 78748 KIAA0237 gene product 5. 00 6. 84 429667 AA456275 Hs. 44841 ESTs 3. 09 6. 80 403008 c21p3_2374 exon 3. 04 6. 78 446079 T56522 Hs. 154030 ESTs 3. 11 6. 75 441869 NM 003947 Hs. 8004 huntingtin-associated protein interactin 4. 49 6. 75 437804 AA828257 Hs. 124324 ESTs 3. 42 6. 73 436454 AA757615 Hs. 291509 ESTs 3. 01 6. 72 416334 H53139 Hs. 36271 ESTs 3. 12 6. 70 455965 BE167014 gb : CM2-HT0502-140200-088-dO8 HT0502 Homo 3. 05 6. 68 445085 A1569295 Hs. 179285 ESTs 3. 19 6. 68 445611 AW418497 Hs. 145583 ESTs 3. 61 6. 68 437762 T78028 Hs. 154679 synaptotagmin 1 7. 21 6. 68 416268 H49111 gb : yo21cO7. r1 SoaresaduitbrainN2b5HB5 3. 02 6. 67 449766 Au668690 Hs. 54773 ESTs 3. 25 6. 64 443100 A1033188 gb : ow94eO8. s1 SoaresJetaJiver_spleen_ 3. 07 6. 64 40. 8070 AW148852 gb : xf05dO5. x1 NCl_CGAP_Bm35Homosapien 3. 12 6. 60 451602 AW008846 Hs. 60857 ESTs 3. 05 6. 59 441447 AA934077 Hs. 126980 ESTs 4. 06 6. 59 445078 A1869975 Hs. 4775 junctophilin 3 4. 25 6. 59 434501 AF143878 Hs. 194152 Homo sapiens clone IMAGE : 115304mRNAseq 3. 25 6. 58 415960 R49020 Hs. 24974 ESTs 3. 34 6. 58 403395 c3p1 11541 exon 3. 59 6. 57 403061 c2p1 10450 exon 3. 06 6. 56 419232 Ai382037 Hs. 87421 ESTs 3. 28 6. 56 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 6. 50 6. 56 403717 c4p1_3133 exon 3. 52 6. 53 452178 AW043576 Hs. 171929 ESTs 3. 38 6. 53 455758 R15709 Hs. 284231 Novel human gene mapping to chomosome 22 4. 42 6. 52 433858 N69243 Hs. 192974 Homo sapiens cDNA FW12735 fis, clone NT 3. 58 6. 52 425440 AA357518 gb : EST66256 LNCAP cells I Homo sapiens c 3. 15 6. 49 419412 AW161058 Hs. 90297 synuclein, beta 5. 60 6. 47 423678 AW963357 Hs. 7847 ESTs 3. 47 6. 47 416625 R97839 Hs. 35758 ESTs 3. 10 6. 46 451854 T92536 Hs. 194096 ESTs 3. 28 6. 46 406732 AA487229 Hs. 2064 vimentin 3. 71 6. 44 434619 H43163 Hs. 32810 ESTs 3. 05 6. 44 413797 BE167274 Hs. 5996 ESTs 3. 23 6. 44 438612 AW977980 Hs. 292129 ESTs 3. 39 6. 42 412317 AW991979 gb : RC1-BN0014-210100-012-f05 BN0014 Homo 3. 46 6. 42 422159 N76767 Hs. 153406 ESTs 3. 03 6. 41

429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 3. 46 6. 35 427334 R44789 Hs. 119486 ESTs, Weakly similar to transmembrane re 3. 93 6. 35 453839 AL138417 gb : DKFZp434B1729 r1 434 (synonym : htes3) 3. 06 6. 34 429096 AB011106 Hs. 196012 KIAA0534 protein 3. 12 6. 33 444609 AW571659 Hs. 278081 ESTs 3. 30 6. 33 419515 S81944 Hs. 90791 gamma-aminobutyricacid (GABA) A recepto 3. 11 6. 33 418900 BE207357 Hs. 301709 ESTs 3. 14 6. 30 437979 AA774318 Hs. 121708 ESTs 3. 25 6. 29 410359 R38624 Hs. 106313 ESTs 4. 74 6. 28 415990 R76929 Hs. 29633 ESTs 3. 39 6. 28 419392 W28573 gb : 51f10Human retina cDNArandomly prim 3. 00 6. 28 424312 AB013452 Hs. 144931 ATPase, aminophospholipid transporter (A 3. 06 6. 26 444762 A ! 733700 Hs. 143883 ESTs 3. 09 6. 25 447785 AL041765 Hs. 161423 ESTs 3. 05 6. 22 418199 AA884555 Hs. 86603 ESTs 3. 55 6. 22 440582 AA993337 Hs. 129082 ESTs 3. 73 6. 21 457766 AL119470 Hs. 145631 ESTs 3. 69 6. 21 426814 AF036943 Hs. 172619 KIAA1106 protein 4. 71 6. 21 412018 BE148152 gb : RC4-HT0231-041199-012-b04 HT0231 Homo 3. 36 6. 21 414699 At815523 Hs. 76930 synuclein, alpha (non A4 component of am 3. 68 6. 19 420127 AA360399 Hs. 44811 ESTs 3. 54 6. 18 418833 AW974899 Hs. 292776 ESTs 3. 08 6. 18 441265 AA927180 Hs. 153261 ESTs 3. 21 6. 17 413408 R51793 Hs. 21745 ESTs 3. 56 6. 15 434512 AW139932 Hs. 188941 ESTs 3. 56 6. 15 422253 W81526 Hs. 118329 ESTs 5. 04 6. 10 439950 AW937417 Hs. 293561 ESTs 3. 24 6. 10 417210 N99228 Hs. 49162 ESTs 3. 54 6. 10 414306 BE272198 Hs. 283869 Human DNA sequence from clone RP5-1013A2 3. 35 6. 10 411265 AW834695 gb : RCO-LT0001-261199-031-D05LT0001Homo 3. 07 6. 10 412734 AW993498 gb : RC2-BN0033-170300-019-b08BN0033Homo 3. 36 6. 09 425172 AA447729 Hs. 12714 ESTs 5. 40 6. 06 451759 W23161 Hs. 32886 ESTs 3. 21 6. 02 432154 Al701523 Hs. 112577 ESTs 3. 50 6. 02 401313 c13p1 435 exon 3. 92 5. 96 446951 A1350575 Hs. 156730 ESTs 3. 20 5. 95 440917 AA909651 Hs. 160025 ESTs 3. 06 5. 94 405961 ph014521 exon 3. 12 5. 91 428737 AA984728 Hs. 192760 kinesin family member 5A 3. 05 5. 90 417292 N69197 Hs. 191361 ESTs 3. 62 5. 89 448681 AL109781 Hs. 21754 Homo sapiens mRNA full length insert cDN 3. 52 5. 88 452524 AW136499 Hs. 29796 Homo sapiens mRNA : cDNA DKFZp434D1319 (f 3. 07 5. 88 426575 M74826 Hs. 170808 glutamate decarboxylase 2 (pancreatic is 4. 08 5. 87 423641 AL137256 Hs. 130489 Homo sapiens mRNA ; cDNA DKFZp761 K0912 (f 3. 28 5. 87 420755 A1699437 Hs. 165268 ESTs 3. 17 5. 86 448116 AW352276 Hs. 170700 ESTs 3. 28 5. 86 412694 AW984373 gb : PM3-HN0011-200300-001-f01 HN0011 Homo 3. 00 5. 83 437612 AA827715 Hs. 105153 Homo sapiens cDNA FLJ14230 s, clone NT 3. 09 5. 82 411522 AW850286 gb : IL3-CT0219-161199-031-H11 CT0219 Homo 3. 26 5. 81 456910 BE185921 Hs. 98073 ESTs 3. 20 5. 80 439915 A1521791 Hs. 252358 ESTs 3. 55 5. 80 404403 c8p1 1094 exon 3. 23 5. 80 405332 cNp3_13017 exon 3. 51 5. 78 411167 AW820204 gb : QV2-ST0296-190100-029c11 ST0296Homo 3. 04 5. 78 416139 H21109 Hs. 172853 ESTs 3. 63 5. 77 434222 AF119886 Hs. 283941 Homo sapiens PR02591 mRNA, complete cds 3. 65 5. 77 415247 F02431 Hs. 6581 ESTs 3. 08 5. 75 446037 A1076806 Hs. 282965 ESTs 3. 42 5. 75 450478 AW451709 Hs. 271200 ESTs 3. 80 5. 72 446588 AV659343 Hs. 282954 ESTs 3. 29 5. 72 413118 BE065939 gb : RC3BT0319-100100-012-c11 BT0319Homo 3. 03 5. 72 416946 NM012324 Hs. 80545 mitogen-activated protein kinase 8 inter 3. 91 5. 72 454751 AW819132 gb : RC3ST0281-240400-015-c10ST0281 Homo 3. 06 5. 72 457194 H20669 Hs. 35406 ESTs, Highly similar to unnamed protein 3. 54 5. 71 438601 AA811713 Hs. 163222 ESTs 3. 26 5. 71 439032 AA829487 Hs. 274412 similar to yeast Upf3, variant A 3. 10 5. 67 408940 M58583 Hs. 662 cerebellin 1 precursor 3. 32 5. 67 437700 AA766060 Hs. 122848 ESTs 3. 23 5. 66 416061 R45516 Hs. 26119 ESTs 3. 85 5. 65 452861 BE177663 gb : RC1-HT0598-020300-011-h11 HT0598Homo 3. 04 5. 64 430330 AA476583 Hs. 132981 ESTs 3. 51 5. 63 435312 AJ243396 Hs. 4865 voltage-gated sodium channel beta-3 subu 5. 67 5. 62 400710 c11p1_1297 exon 3. 04 5. 61 457130 NM 005651 Hs. 183671 tryptophan 2, 3-dioxygenase 3. 31 5. 60 434513 AF143888 Hs. 18213 Homo sapiens clone IMAGE : 121736mRNAseq 3. 93 5. 60 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 3. 67 5. 58 440854 AW444900 Hs. 246715 ESTs 3. 30 5. 58 457086 AA412591 Hs. 204685 ESTs 3. 37 5. 57 431883 AA731404 Hs. 105510 ESTs 3. 67 5. 56 400758 AA158742 Hs. 225084 Homo sapiens cDNA FU14280 fis, clone PL 3. 43 5. 55 455374 AW904039 gb : CM3NN1040-200400-156-dO3NN1040Homo 3. 36 5. 52 440750 AW105131 Hs. 245405 ESTs 3. 10 5. 50 451865 H43737 Hs. 33186 ESTs, Weakly similar to unknown protein 3. 38 5. 50

453100 AW806871 Hs. 224786 ESTs 3. 30 5. 49 433940 H05129 Hs. 7459 cyclic AMP-regulated phosphoprotein, 21 3. 24 5. 49 454935 AW846075 gb : MR3-CT0176-081099-002-b02CT0176Homo 3. 26 5. 48 435447 A1872932 Hs. 142442 HP1-BP74 3. 89 5. 47 402953 c20p3_3451 exon 3. 28 5. 47 456233 AA203339 gb : zx56a01. r1 Soares fetal_liver_spieen_ 3. 02 5. 47 407718 AW070784 Hs. 243243 EST 3. 30 5. 45 417429 Api950629 Hs. 286237 HomosapienscDNAFW11841 fis, cloneHE 3. 31 5. 38 446408 A1797169 Hs. 208486 ESTs 3. 07 5. 37 441792 AW873635 Hs. 143962 ESTs 3. 19 5. 35 450661 AW952160 Hs. 32916 ESTs 3. 70 5. 35 433932 AW954599 Hs. 169330 neuronal protein 6. 78 5. 33 427002 AA524093 Hs. 23158 ESTs 4. 00 5. 32 428741 AA461386 gb : zx70hO6. r1 Soares total fetus Nb2HF8 3. 10 5. 32 446383 T05816 Hs. 92511 EST 3. 39 5. 30 442988 A1026130 Hs. 131683 ESTs 3. 07 5. 29 426713 A1655299 Hs. 130055 ESTs 3. 33 5. 29 421294 AA713486 Hs. 180291 ESTs 3. 44 5. 28 406452 ph2_21981 exon 3. 20 5. 28 423508 AW604297 Hs. 129711 hepatits A virus cellular receptor 1 3. 26 5. 27 442114 BE217975 Hs. 157021 ESTs 3. 32 5. 26 432508 A1808915 Hs. 190201 ESTs 3. 46 5. 26 425604 U94320 Hs. 158330 neuropeptide Y receptor Y5 3. 26 5. 23 417925 R26789 Hs. 23995 ESTs 3. 08 5. 23 444448 H66317 Hs. 143660 ESTs 3. 81 5. 22 413024 AF036268 Hs. 75149 SH3domanGRB2-Dke2 3. 71 5. 22 437911 AA848010 Hs. 124250 ESTs 3. 11 5. 18 435406 F26698 Hs. 4884 calcium/calmodulin-dependent protein kin 4. 95 5. 17 407131 R98679 gb : yr31c03. s1Soaresfetalliverspleen 3. 30 5. 16 435776 A1537162 Hs. 263988 ESTs 3. 14 5. 13 455532 AW984828 gb : RC1-HN0015-120400-021-h11 HN0015Homo 3. 14 5. 13 457352 AA489099 gb : aa56h09. s1 NCI CGAP_GCB1 Homosapiens 3. 48 5. 12 428670 AA431682 Hs. 134832 ESTs 3. 17 5. 12 445962 A1268410 Hs. 201386 ESTs 3. 14 5. 12 418153 R13696 Hs. 112830 ESTs 3. 16 5. 10 440565 AW103823 Hs. 131586 ESTs 3. 08 5. 10 431446 AW294929 Hs. 255369 Homo sapiens cDNA FLJ10265 fis, clone HE 3. 42 5. 09 456036 BE536554 Hs. 75839 zinc finger protein 6 (CMPX1) 3. 21 5. 09 420883 A1735488 Hs. 111436 ESTs 3. 17 5. 08 455528 AW984757 gb : RC1-HN0015-040400-011-g10HN0015Homo 3. 35 5. 08 408442 R59608 Hs. 21435 ESTs 3. 10 5. 07 446093 Al346849 Hs. 145896 ESTs 3. 30 5. 06 403489 c3p12255 exon 3. 43 5. 05 405278 cNp3_1070 exon 3. 05 5. 03 412804 H18857 Hs. 22547 ESTs 3. 63 5. 03 458407 W90022 Hs. 186809 ESTs, Highly similar to LECT2 precursor 3. 52 5. 03 407367 AA130773 gb : zo13dO1. r1 Stratagene colon (937204) 3. 51 5. 02 439108 AW163034 Hs. 6467 synaptogyrin 3 5. 63 5. 01 445335 A1220339 Hs. 166775 ESTs 3. 21 5. 01 435404 A1240661 Hs. 124995 ESTs 3. 99 5. 00 TABLE 6B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 410837 282574_1 AW806917 AW866469 BF898475 BF898476 AW866540 AW866614 BE145698AW866575 436812 659779 1 AW978773 AW298067 AA810101 AW194180 AA731645 AI690673 454171 1049240 1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 454589 28039 6 BG674750 BF374578 AW810080 AW810106 AW810084 BF374755 AW809621 BF374734 BF374590 BF374594 AW809699 BF374588 AW810437 AW810161 AW809662AW810151 417159 2075888_1 R01760 N49787 R01761 459349 1027822_1 AW749381 H93337 414187 315279_1 BE259777 BE312141 BF942980 423280 881045_1 AW955178H86636M324037 431400 1233916_1 AW969094M504607M504705 454566 164604_1 AW807605 AW807690 AW807677 AW807752 AW807673 AW807900 AW807955AW807679 AW807615 AW807917 AW807849AW807832 AW807821 AW807842 AW807827 AW807754 AW807830 AW807829 AW807825 AW807819 AW807769 AW807685 AW807603 AW807763 AW807612 AW807840 AW807908 AW807684 AW807609 AW807596 AW807595 AW807593 AW807907 AW807902 AW807846 AW807756 AW807687 AW807836 AW807835 AW807770 AW807753 AW807669 AW807678 AW807686 AW807680 AW807688 AW807847 AW807957 AW807674 AW807602 AW807617 AW807921 AW807667 AW807952 AW807918 AW807670 AW807760 AW807956 AW807608 AW807683 AW807839 AW807601 AW807822 AW807898 437948 330397_1 M772920 D59870 D61151 Ai591331 BF960996 438919 1242618 1 AW979114 AA828060 AA837606 AA829203 454578 1670 3 BE150647 AW971143 AW809224 AW809221 BF753820 AW809220 AW809178 AW809150 AW809195 AW809175 455836 1518824J BE145800 BE145921 BE145873 BE145871 BE145930 BE145797 BE145795 454968 1085677_1 AW848279 AW849039 AW847956 AW847957 AW849046 AW848698 AW849034 AW849033 418162 2189291 1 T11756 T20135 T19729 T11958T11816 R45874 431169 1235760_1 AW971240M493723M493843 458172 363900 1 BE007237 BE546311 AA984819 B1256810 W19919 BE007263 BG000322 BF327011 AA890198 BE007496 412172 709034 1 W04156 AW897535 N94221 427942 465847 1 BE543651 AA417856 AV756446 BG505084 B ! 460307 Bl460993 BG613293 454688 1066481 1 BF375123 AW814472 AW814474 AW813343 AW816161 AW813380 AW813300

455675 1490763 1 BE065984 BE066085 BE065942 BE065955 455644 1489581 1 BE064521 BE064441 BE064426 BE064285 BE064286 451496 85420 1 AA046879 BF327988 AW503407 AA018131 424617 895912J AW963059AA344151AA344472 454962 323094_1 AW853945 AW854083 BF962818 AW847791 Bl035483 AW847645 BF961514 BF963484 BF952264 BF963521 455260 231032 1 BE161805AW878317BE161759BF870032BF869588 434589 14676 1 AF147363T47219T47218 410926 1064369_1 AW810708AW810808AW810771AW810924 409623 830636 1 AW449665 BE220971 AW449185 437254 12398761 AW976161AA831258AA765857AA747712A ! 784019 415508 1874742_1 R45579 F10822 R39236 413263 1497122J BE075132 BE075131 BE075130 D60395 BF688035 415967 1899490 1 H49130H11230BF363165H49061H11124 417555 1978200 1 AA203678 AL597143 H65366 413547 1520005 1 BE147456 BE147563 BE147708 BE147440 411132 1070974 1 AW819177 AW819242 AW819191 AW819175 AW819252 AW819244 AW819265 AW819269 AW819190 AW819268 AW819183 AW819246 AW819194 AW819249 AW819186 AW819180AW819188 BE158470 AW819251 BE152602 AW819263 454568 1061859_1 AW807909 AW807824 AW807826AW807903AW807766 AW807750 AW807911 BE141434 AW807611 AW807837 AW807899 BF374481 413162 1492355 1 BE068104 BE068096 BE068198 BE068115 BE068102 BE068154 BE068103 455377 154707_1 BF947516 AW905291 BF947512 BF952606 BF952706 BF952525 BF952524 BF952619 BF947500 BF952608 BF952523 BF952532 BF952344 BF746516 BF947614 BF746511 BF952358 AW905400 AW905300 BF947617 AW905349 BF952531 AW905403 BF952528 BE081655 BF746513 AW905286 BF952868 BF947513 BF947510 BF947618 BF947619 AW905347 455149 1099453 1 AW861879 AW861948 AW858447 AW861873 AW858418 AW861871 412686 1243154 1 AW984068AW984077AW984072 436383 4676lu AJ227879 BE065178 BE065329 412290 1163352 1 BE069037BE069178AW936034AW936025 411427 1083097 1 AW846080 AW846074 AW846118 AW846130 410816 1060611_1 AW806175 AW806176 AW806170 AW806156 447258 1485710 1 BE617316BE047911M984167 455547 1245954 1 AW994078BE176183 432209 1235790 1 AW971278 AA528270 AA553447 AW971281 411138 1071173 AW819500AW819503AW819481AW819459BF375618 454713 1067889_1 AW815111 AW815094AW815218 455965 1555935 1 BE167014BE167058BE167062 416268 1959926 1 H41854H49111 H46317 443100 416959 1 BE004743 AW804074 BE089437 BE089439 BE089378 BE089438 BE004795 W02375 A1033188 BF332422 BF332418 BE178660 408070 632273 1 AW148852BG994152 425440 1228191_1 AW962960M357518M360531 412317 1164038 1 AW991979AW991981AW991983AW936856AW991977AW991971AW936852 453839 3209657 1 AL138417AL138418 419392 2155622 W28573W27418 412018 147109 1 BE148133 BE148132 BF736564 BE148152 BE148159 BF893700 411265 1074383 1 AW834695 AW834717 AW834714 412734 1245451 1 AW993498 AW993484 AW993490 BF512974 412694 1243393 1 AW984388 AW984392 AW984379 AW984351 AW984381 AW984377 AW984366 AW984348 AW984391 AW984373 AW984372 AW984353 AW984362 411522 1089092 1 BE143505BF374194BF374190AW850286 411167 1071740 1 AW820323AW820314AW820321 413118 1490760 1 BE066079 BE065939 BE065956 454751 1070838J AW819132 AW819122 AW819018 AW819135 AW819126 AW819024AW819012AW819141 452861 319757_1 BE177663AW994738Ai923735BF948431 BF948329 455374 1161013 1 AW904029 AW904030 AW904039 AW904031 AW904032 AW904046 454935 1083098 1 AW846075 AW846103 BF333976 AW846077AW846122 AW846129 AW846095 AW846076 BF333979 BF333978AW846092 456233 26357441 AA203339AA906160AA929005 428741 1384399 1 AA461386 AA433841 AA433845 455532 1243692_1 AW984828 AW984787 AW984806 AW984817 AW984826 AW984822 AW984773 AW984786 AW984803 AW984796 457352 1233795_1 AW968988M489099N72933M489184 455528 1243660 1 AW984734AW984757AW984797AW984745 407367 49071 AF085963H72550H72951AA130773 TABLE 6C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers."Dunham, et a !."refers to the publication entitled"The DNA sequence of human chromosome 22"Dunham, et al. (1999} Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nu position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 401412 7940103 Minus 43347-45776 405230 7249032 Minus 97493-97682 402125 4033680 Plus 172732-172868 404289 2769644 Plus 15049-15286, 30267-30457 406534 7711477 Plus 40463-40586, 41191-41336, 41856-41986, 4300 405348 2914717 Minus 43310-43462 401081 3478647 Plus 105163-105305 402624 7885063 Minus 31308-31439 405320 3478667 Minus 118511-118926, 119175-119331 405476 2121229 Plus 69890-70883 403932 7454203 Minus 8142-8753 406112 9133145 Plus 61863-62028 400708 7249204 Plus 118115-119445 405427 7243901 Minus 6509-6729 402816 6723302 Minus 25104-25291 404541 8318559 Plus 103456-103664

403008 6070396 Plus 94608-94785, 95096-95233 403395 9438353 Minus 144947-145075 403061 8954192 Plus 142875-143008 403717 7259747 Minus 79166-79758 401313 9212516 Minus 190842-191090 405961 8190197 Plus 45132-45254 404403 7272157 Minus 72053-72238 405332 3169141 Minus 70483-71207 400710 7249204 Plus 156753-157120 402953 9408724 Minus 122603-122743 406452 9588380 Minus 76322-76427 403489 7331314 Minus 38897-39212 405278 6139075 Minus 3863-3965, 4823-4891, 5439-5529, 6043-6170 TABLE 7A : EXTENDED GLIOBLASTOMA SEQUENCES : This table includes sequence information for 21 DNA and protein sequences DNA sequence 1 Gene name : Protein tyrosine phosphatase, receptor-type, Z polypeptide 1 Unigene number : Hs. 78867 Probeset Accession ? : M93426 Nucleic Acid Accession # : NM002851 Coding sequence : 148-7092 1 11 21 31 41 51 CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60 CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120 CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180 CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240 CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300 AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360 CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420 AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480 GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540 AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600 GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660 GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720 GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780 TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840 AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900 ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960 TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020 TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080 AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140 TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200 CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260 GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320 TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380 AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440 GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500 AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560 ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620 AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680 ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740 GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800 AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860 AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920 GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980 GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040 GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100 GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160 AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220 TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280 CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340 TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400 GTATACAATG GTGAGACACC TCTTCAACCT TCCTACAGTA GTGAAGTCTT TCCTCTAGTC 2460 ACCCCTTTGT TGCTTGACAA TCAGATCCTC AACACTACCC CTGCTGCTTC AAGTAGTGAT 2520 TCGGCCTTGC ATGCTACGCC TGTATTTCCC AGTGTCGATG TGTCATTTGA ATCCATCCTG 2580 TCTTCCTATG ATGGTGCACC TTTGCTTCCA TTTTCCTCTG CTTCCTTCAG TAGTGAATTG 2640 TTTCGCCATC TGCATACAGT TTCTCAAATC CTTCCACAAG TTACTTCAGC TACCGAGAGT 2700 GATAAGGTGC CCTTGCATGC TTCTCTGCCA GTGGCTGGGG GTGATTTGCT ATTAGAGCCC 2760 AGCCTTGCTC AGTATTCTGA TGTGCTGTCC ACTACTCATG CTGCTTCAGA GACGCTGGAA 2820 TTTGGTAGTG AATCTGGTGT TCTTTATAAA ACGCTTATGT TTTCTCAAGT TGAACCACCC 2880 AGCAGTGATG CCATGATGCA TGCACGTTCT TCAGGGCCTG AACCTTCTTA TGCCTTGTCT 2940 GATAATGAGG GCTCCCAACA CATCTTCACT GTTTCTTACA GTTCTGCAAT ACCTGTGCAT 3000 GATTCTGTGG GTGTAACTTA TCAGGGTTCC TTATTTAGCG GCCCTAGCCA TATACCAATA 3060 CCTAAGTCTT CGTTAATAAC CCCAACTGCA TCATTACTGC AGCCTACTCA TGCCCTCTCT 3120 GGTGATGGGG AATGGTCTGG AGCCTCTTCT GATAGTGAAT TTCTTTTACC TGACACAGAT 3180 GGGCTGACAG CCCTTAACAT TTCTTCACCT GTTTCTGTAG CTGAATTTAC ATATACAACA 3240 TCTGTGTTTG GTGATGATAA TAAGGCGCTT TCTAAAAGTG AAATAATATA TGGAAATGAG 3300 ACTGAACTGC AAATTCCTTC TTTCAATGAG ATGGTTTACC CTTCTGAAAG CACAGTCATG 3360 CCCAACATGT ATGATAATGT AAATAAGTTG AATGCGTCTT TACAAGAAAC CTCTGTTTCC 3420 ATTTCTAGCA CCAAGGGCAT GTTTCCAGGG TCCCTTGCTC ATACCACCAC TAAGGTTTTT 3480 GATCATGAGA TTAGTCAAGT TCCAGAAAAT AACTTTTCAG TTCAACCTAC ACATACTGTC 3540 TCTCAAGCAT CTGGTGACAC TTCGCTTAAA CCTGTGCTTA GTGCAAACTC AGAGCCAGCA 3600

TCCTCTGACC CTGCTTCTAG TGAAATGTTA TCTCCTTCAA CTCAGCTCTT ATTTTATGAG 3660 ACCTCAGCTT CTTTTAGTAC TGAAGTATTG CTACAACCTT CCTTTCAGGC TTCTGATGTT 3720 GACACCTTGC TTAAAACTGT TCTTCCAGCT GTGCCCAGTG ATCCAATATT GGTTGAAACC 3780 CCCAAAGTTG ATAAAATTAG TTCTACAATG TTGCATCTCA TTGTATCAAA TTCTGCTTCA 3840 AGTGAAAACA TGCTGCACTC TACATCTGTA CCAGTTTTTG ATGTGTCGCC TACTTCTCAT 3900 ATGCACTCTG CTTCACTTCA AGGTTTGACC ATTTCCTATG CAAGTGAGAA ATATGAACCA 3960 GTTTTGTTAA AAAGTGAAAG TTCCCACCAA GTGGTACCTT CTTTGTACAG TAATGATGAG 4020 TTGTTCCAAA CGGCCAATTT GGAGATTAAC CAGGCCCATC CCCCAAAAGG AAGGCATGTA 4080 TTTGCTACAC CTGTTTTATC AATTGATGAA CCATTAAATA CACTAATAAA TAAGCTTATA 4140 CATTCCGATG AAATTTTAAC CTCCACCAAA AGTTCTGTTA CTGGTAAGGT ATTTGCTGGT 4200 ATTCCAACAG TTGCTTCTGA TACATTTGTA TCTACTGATC ATTCTGTTCC TATAGGAAAT 4260 GGGCATGTTG CCATTACAGC TGTTTCTCCC CACAGAGATG GTTCTGTAAC CTCAACAAAG 4320 TTGCTGTTTC CTTCTAAGGC AACTTCTGAG CTGAGTCATA GTGCCAAATC TGATGCCGGT 4380 TTAGTGGGTG GTGGTGAAGA TGGTGACACT GATGATGATG GTGATGATGA TGATGACAGA 4440 GATAGTGATG GCTTATCCAT TCATAAGTGT ATGTCATGCT CATCCTATAG AGAATCACAG 4500 GAAAAGGTAA TGAATGATTC AGACACCCAC GAAAACAGTC TTATGGATCA GAATAATCCA 4560 ATCTCATACT CACTATCTGA GAATTCTGAA GAAGATAATA GAGTCACAAG TGTATCCTCA 4620 GACAGTCAAA CTGGTATGGA CAGAAGTCCT GGTAAATCAC CATCAGCAAA TGGGCTATCC 4680 CAAAAGCACA ATGATGGAAA AGAGGAAAAT GACATTCAGA CTGGTAGTGC TCTGCTTCCT 4740 CTCAGCCCTG AATCTAAAGC ATGGGCAGTT CTGACAAGTG ATGAAGAAAG TGGATCAGGG 4800 CAAGGTACCT CAGATAGCCT TAATGAGAAT GAGACTTCCA CAGATTTCAG TTTTGCAGAC 4860 ACTAATGAAA AAGATGCTGA TGGGATCCTG GCAGCAGGTG ACTCAGAAAT AACTCCTGGA 4920 TTCCCACAGT CCCCAACATC ATCTGTTACT AGCGAGAACT CAGAAGTGTT CCACGTTTCA 4980 GAGGCAGAGG CCAGTAATAG TAGCCATGAG TCTCGTATTG GTCTAGCTGA GGGGTTGGAA 5040 TCCGAGAAGA AGGCAGTTAT ACCCCTTGTG ATCGTGTCAG CCCTGACTTT TATCTGTCTA 5100 GTGGTTCTTG TGGGTATTCT CATCTACTGG AGGAAATGCT TCCAGACTGC ACACTTTTAC 5160 TTAGAGGACA GTACATCCCC TAGAGTTATA TCCACACCTC CAACACCTAT CTTTCCAATT 5220 TCAGATGATG TCGGAGCAAT TCCAATAAAG CACTTTCCAA AGCATGTTGC AGATTTACAT 5280 GCAAGTAGTG GGTTTACTGA AGAATTTGAG ACACTGAAAG AGTTTTACCA GGAAGTGCAG 5340 AGCTGTACTG TTGACTTAGG TATTACAGCA GACAGCTCCA ACCACCCAGA CAACAAGCAC 5400 AAGAATCGAT ACATAAATAT CGTTGCCTAT GATCATAGCA GGGTTAAGCT AGCACAGCTT 5460 GCTGAAAAGG ATGGCAAACT GACTGATTAT ATCAATGCCA ATTATGTTGA TGGCTACAAC 5520 AGACCAAAAG CTTATATTGC TGCCCAAGGC CCACTGAAAT CCACAGCTGA AGATTTCTGG 5580 AGAATGATAT GGGAACATAA TGTGGAAGTT ATTGTCATGA TAACAAACCT CGTGGAGAAA 5640 GGAAGGAGAA AATGTGATCA GTACTGGCCT GCCGATGGGA GTGAGGAGTA CGGGAACTTT 5700 CTGGTCACTC AGAAGAGTGT GCAAGTGCTT GCCTATTATA CTGTGAGGAA TTTTACTCTA 5760 AGAAACACAA AAATAAAAAA GGGCTCCCAG AAAGGAAGAC CCAGTGGACG TGTGGTCACA 5820 CAGTATCACT ACACGCAGTG GCCTGACATG GGAGTACCAG AGTACTCCCT GCCAGTGCTG 5880 ACCTTTGTGA GAAAGGCAGC CTATGCCAAG CGCCATGCAG TGGGGCCTGT TGTCGTCCAC 5940 TGCAGTGCTG GAGTTGGAAG AACAGGCACA TATATTGTGC TAGACAGTAT GTTGCAGCAG 6000 ATTCAACACG AAGGAACTGT CAACATATTT GGCTTCTTAA AACACATCCG TTCACAAAGA 6060 AATTATTTGG TACAAACTGA GGAGCAATAT GTCTTCATTC ATGATACACT GGTTGAGGCC 6120 ATACTTAGTA AAGAAACTGA GGTGCTGGAC AGTCATATTC ATGCCTATGT TAATGCACTC 6180 CTCATTCCTG GACCAGCAGG CAAAACAAAG CTAGAGAAAC AATTCCAGCT CCTGAGCCAG 6240 TCAAATATAC AGCAGAGTGA CTATTCTGCA GCCCTAAAGC AATGCAACAG GGAAAAGAAT 6300 CGAACTTCTT CTATCATCCC TGTGGAAAGA TCAAGGGTTG GCATTTCATC CCTGAGTGGA 6360 GAAGGCACAG ACTACATCAA TGCCTCCTAT ATCATGGGCT ATTACCAGAG CAATGAATTC 6420 ATCATTACCC AGCACCCTCT CCTTCATACC ATCAAGGATT TCTGGAGGAT GATATGGGAC 6480 CATAATGCCC AACTGGTGGT TATGATTCCT GATGGCCAAA ACATGGCAGA AGATGAATTT 6540 GTTTACTGGC CAAATAAAGA TGAGCCTATA AATTGTGAGA GCTTTAAGGT CACTCTTATG 6600 GCTGAAGAAC ACAAATGTCT ATCTAATGAG GAAAAACTTA TAATTCAGGA CTTTATCTTA 6660 GAAGCTACAC AGGATGATTA TGTACTTGAA GTGAGGCACT TTCAGTGTCC TAAATGGCCA 6720 AATCCAGATA GCCCCATTAG TAAAACTTTT GAACTTATAA GTGTTATAAA AGAAGAAGCT 6780 GCCAATAGGG ATGGGCCTAT GATTGTTCAT GATGAGCATG GAGGAGTGAC GGCAGGAACT 6840 TTCTGTGCTC TGACAACCCT TATGCACCAA CTAGAAAAAG AAAATTCCGT GGATGTTTAC 6900 CAGGTAGCCA AGATGATCAA TCTGATGAGG CCAGGAGTCT TTGCTGACAT TGAGCAGTAT 6960 CAGTTTCTCT ACAAAGTGAT CCTCAGCCTT GTGAGCACAA GGCAGGAAGA GAATCCATCC 7020 ACCTCTCTGG ACAGTAATGG TGCAGCATTG CCTGATGGAA ATATAGCTGA GAGCTTAGAG 7080 TCTTTAGTTT AACACAGAAA GGGGTGGGGG GACTCACATC TGAGCATTGT TTTCCTCTTC 7140 CTAAAATTAG GCAGGAAAAT CAGTCTAGTT CTGTTATCTG TTGATTTCCC ATCACCTGAC 7200 AGTAACTTTC ATGACATAGG ATTCTGCCGC CAAATTTATA TCATTAACAA TGTGTGCCTT 7260 TTTGCAAGAC TTGTAATTTA CTTATTATGT TTGAACTAAA ATGATTGAAT TTTACAGTAT 7320 TTCTAAGAAT GGAATTGTGG TATTTTTTTC TGTATTGATT TTAACAGAAA ATTTCAATTT 7380 ATAGAGGTTA GGAATTCCAA ACTACAGAAA ATGTTTGTTT TTAGTGTCAA ATTTTTAGCT 7440 GTATTTGTAG CAATTATCAG GTTTGCTAGA AATATAACTT TTAATACAGT AGCCTGTAAA 7500 TAAAACACTC TTCCATATGA TATTCAACAT TTTACAACTG CAGTATTCAC CTAAAGTAGA 7560 AATAATCTGT TACTTATTGT AAATACTGCC CTAGTGTCTC CATGGACCAA ATTTATATTT 7620 ATAATTGTAG ATTTTTATAT TTTACTACTG AGTCAAGTTT TCTAGTTCTG TGTAATTGTT 7680 TAGTTTAATG ACGTAGTTCA TTAGCTGGTC TTACTCTACC AGTTTTCTGA CATTGTATTG 7740 TGTTACCTAA GTCATTAACT TTGTTTCAGC ATGTAATTTT AACTTTTGTG GAAAATAGAA 7800 ATACCTTCAT TTTGAAAGAA GTTTTTATGA GAATAACACC TTACCAAACA TTGTTCAAAT 7860 GGTTTTTATC CAAGGAATTG CAAAAATAAA TATAAATATT GCCATTAAAA AAAAAAAAAA 7920 AAAAAAAAAA AAAAAAAAAA A Protein sequence 1 Gene name : Protein tyrosine phosphatase, receptor-type, Z polypeptide 1 Unigene number : Hs. 78867 Protein Accession # : NP 002842 Signal sequence : 1-20 Pfam domain : carb anhydrase [38-300] Transmembrane domains : 1639-1661 Cellular Localization : plasma membrane 1 11 21 31 41 51

MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120 FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TMERPRWYD TMIEKFAVLY QQLDGEDQTK 360 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720 TEVTPHAFTP SSRQQDLVST VNVVYSQTTQ PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI 780 LNTTPAASSS DSALHATPVF PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ 840 ILPQVTSATE SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY 900 KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV HDSVGVTYQG 960 SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGEWSGAS SDSEFLLPDT DGLTALNISS 1020 PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN ETELQIPSFN EMVYPSESTV MPNMYDNVNK 1080 LNASLQETSV SISSTKGMFP GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL 1140 KPVLSANSEP ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP 1200 AVPSDPILVE TPKVDKISST MLHLIVSNSA SSENMLHSTS VPVFDVSPTS HMHSASLQGL 1260 TISYASEKYE PVLLKSESSH QWPSLYSND ELFQTANLEI NQAHPPKGRH VFATPVLSID 1320 EPLNTLINKL IHSDEILTST KSSVTGKVFA GIPTVASDTF VSTDHSVPIG NGHVAITAVS 1380 PHRDGSVTST KLLFPSKATS ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD RDSDGLSIHK 1440 CMSCSSYRES QEKVMNDSDT HENSLMDQNN PISYSLSENS EEDNRVTSVS SDSQTGMDRS 1500 PGKSPSANGL SQKHNDGKEE NDIQTGSALL PLSPESKAWA VLTSDEESGS GQGTSDSLNE 1560 NETSTDFSFA DTNEKDADGI LAAGDSEITP GFPQSPTSSV TSENSEVFHV SEAEASNSSH 1620 ESRIGLAEGL ESEKKAVIPL VIVSALTFIC LWLVGILIY WRKCFQTAHF YLEDSTSPRV 1680 ISTPPTPIFP ISDDVGAIPI KHFPKHVADL HASSGFTEEF ETLKEFYQEV QSCTVDLGIT 1740 ADSSNHPDNK HKNRYINIVA YDHSRVKLAQ LAEKDGKLTD YINANYVDGY NRPKAYIAAQ 1800 GPLKSTAEDF WRMIWEHNVE VIVMITNLVE KGRRKCDQYW PADGSEEYGN FLVTQKSVQV 1860 LAYYTVRNFT LRNTKIKKGS QKGRPSGRW TQYHYTQWPD MGVPEYSLPV LTFVRKAAYA 1920 KRHAVGPVW HCSAGVGRTG TYIVLDSMLQ QIQHEGTVNI FGFLKHIRSQ RNYLVQTEEQ 1980 YVFIHDTLVE AILSKETEVL DSHIHAYVNA LLIPGPAGKT KLEKQFQLLS QSNIQQSDYS 2040 AALKQCNREK NRTSSIIPVE RSRVGISSLS GEGTDYINAS YIMGYYQSNE FIITQHPLLH 2100 TIKDFWRMIW DHNAQLWMI PDGQNMAEDE FVYWPNKDEP INCESFKVTL MAEEHKCLSN 2160 EEKLIIQDFI LEATQDDYVL EVRHFQCPKW PNPDSPISKT FELISVIKEE AANRDGPMIV 2220 HDEHGGVTAG TFCALTTLMH QLEKENSVDV YQVAKMINLM RPGVFADIEQ YQFLYKVILS 2280 LVSTRQEENP STSLDSNGAA LPDGNIAESL ESLV DNA SEQUENCE 2 Gene name : tyrosylprotein sulfotransferase 1 Unigene number : Hs. 110903 Probeset Accession # : D61594 Nucleic Acid Accession # : NM 003596 Coding sequence : 82-1194 1 11 21 31 41 51 1 1 1 1 1 1 GTAGACTGTC CATGGCCTGA ACATTTTCCG AAAATCATTT TGAGCAAAAT ATCTGTTTAA 60 TAACAAGATA ACCACATCAA GATGGTTGGA AAGCTGAAGC AGAACTTACT ATTGGCATGT 120 CTGGTGATTA GTTCTGTGAC TGTGTTTTAC CTGGGCCAGC ATGCCATGGA ATGCCATCAC 180 CGGATAGAGG AACGTAGCCA GCCAGTCAAA TTGGAGAGCA CAAGGACCAC TGTGAGAACT 240 GGCCTGGACC TCAAAGCCAA CAAAACCTTT GCCTATCACA AAGATATGCC TTTAATATTT 300 ATTGGRGGTG TGCCTCGGAG TGGAACCACA CTCATGAGGG CCATGCTGGA CGCACATCCT 360 GACATTCGCT GTGGAGAGGA AACCAGGGTC ATTCCCCGAA TCCTGGCCCT GAAGCAGATG 420 TGGTCACGGT CAAGTAAAGA GAAGATCCGC CTGGATGAGG CTGGTGTTAC TGATGAAGTG 480 CTGGATTCTG CCATGCAAGC CTTCTTACTA GAAATTATCG TTAAGCATGG GGAGCCAGCC 540 CCTTATTTAT GTAATAAAGA TCCTTTTGCC CTGAAATCTT TAACTTACCT TTCTAGGTTA 600 TTCCCCAATG CCAAATTTCT CCTGATGGTC CGAGATGGCC GGGCATCAGT ACATTCAATG 660 ATTTCTCGAA AAGTTACTAT AGCTGGATTT GATCTGAACA GCTATAGGGA CTGTTTGACA 720 AAGTGGAATC GTGCTATAGA GACCATGTAT AACCAGTGTA TGGAGGTTGG TTATAAAAAG 780 TGCATGTTGG TTCACTATGA ACAACTTGTC TTACATCCTG AACGGTGGAT GAGAACACTC 840 TTAAAGTTCC TCCAGATTCC ATGGAACCAC TCAGTATTGC ACCATGAAGA GATGATTGGG 900 AAAGCTGGGG GAGTGTCTCT GTCAAAAGTG GAGAGATCTA CAGACCAAGT AATCAAGCCA 960 GTCAATGTAG GAGCTCTATC AAAATGGGTT GGGAAGATAC CGCCAGATGT TTTACAAGAC 1020 ATGGCAGTGA TTGCTCCTAT GCTTGCCAAG CTTGGATATG ACCCATATGC CAACCCACCT 1080 AACTACGGAA AACCTGATCC CAAAATTATT GAAAACACTC GAAGGGTCTA TAAGGGAGAA 1140 TTCCAACTAC CTGACTTTCT TAAAGAAAAA CCACAGACTG AGCAAGTGGA GTAGCAGAAC 1200 CAGGAGCCTC TTCCATACAT GAGGAAAGAT TGCTGCCTTT TCAGCAGAAG GGAAATTCCT 1260 AGGATTGGCT GTCCCCTGCC AAGCTTGGTG GAGCGTCTGC ACCTTGGCTG CGCCGCCTGT 1320 GCATTTGCCA GTTTCCTCCC ACTGAGAGGA TGGAGGTGTC CGCACAGCTT TGGGCCTCGT 1380 GAGGGATCTG CCTCCTGAGC AAAGAGCTCT TGATCCCGAT TTCATGCACA GCCCTGCAGT 1440 AAGGAGCCCA GAAGGAACAT GTGTTTCCTG TTAAAACTCC TCTTGTTCTC TTTTCTTACA 1500 TTATGACGTT TGTTTTCAAG GAGAGGGTTT AAAAATGGGA TCCTGTAAGC AGACTTGGGC 1560 AGTCTCCTTT TGAAATAGGT TGTCTGTACA TGTTCTAATG TTTTGTAGAA CACGTGTGCC 1620 TGTTTAAGTG TATTGATGTG AATAATATTA AATATCCTAA TTATTTAATT CATTGTATTG 1680 TTTCTGAGAA GTTGGGAAAT TACCATTATA CATTTACAAC CTAATGACTT TTGTATTTTA 1740 TTTTTCAAAA TAAAAGCTTT CAATGTGA Protein sequence 2 Gene name : tyrosylprotein sulfotransferase 1 Unigene number : Hs. 110903 Protein Accession # : NP003587 Signal sequence : 1-21

Transmembrane domains : none found Cellular Localization : plasma membrane 1 11 21 31 41 51 1 1 1 1 1 1 MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PVKLESTRTT VRTGLDLKAN 60 KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE TRVIPRILAL KQMWSRSSKE 120 KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG EPAPYLCNKD PFALKSLTYL SRLFPNAKFL 180 LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE 240 QLVLHPERWM RTLLKFLQIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVGALS 300 KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KIIENTRRVY KGEFQLPDFL 360 KEKPQTEQVE DNA sequence 3 Gene name : interleukin 13 receptor, alpha 2 Unigene number : Hs. 25954 Probeset Accession # : R52795 Nucleic Acid Accession # : NM 000640 Coding sequence : 94-1236 1 11 21 31 41 51 I CGGATGAAGG CTATTTGAAG TCGCCATAAC CTGGTCAGAA GTGTGCCTGT CGGCGGGGAG 60 AGAGGCAATA TCAAGGTTTT AAATCTCGGA GAAATGGCTT TCGTTTGCTT GGCTATCGGA 120 TGCTTATATA CCTTTCTGAT AAGCACAACA TTTGGCTGTA CTTCATCTTC AGACACCGAG 180 ATAAAAGTTA ACCCTCCTCA GGATTTTGAG ATAGTGGATC CCGGATACTT AGGTTATCTC 240 TATTTGCAAT GGCAACCCCC ACTGTCTCTG GATCATTTTA AGGAATGCAC AGTGGAATAT 300 GAACTAAAAT ACCGAAACAT TGGTAGTGAA ACATGGAAGA CCATCATTAC TAAGAATCTA 360 CATTACAAAG ATGGGTTTGA TCTTAACAAG GGCATTGAAG CGAAGATACA CACGCTTTTA 420 CCATGGCAAT GCACAAATGG ATCAGAAGTT CAAAGTTCCT GGGCAGAAAC TACTTATTGG 480 ATATCACCAC AAGGAATTCC AGAAACTAAA GTTCAGGATA TGGATTGCGT ATATTACAAT 540 TGGCAATATT TACTCTGTTC TTGGAAACCT GGCATAGGTG TACTTCTTGA TACCAATTAC 600 AACTTGTTTT ACTGGTATGA GGGCTTGGAT CATGCATTAC AGTGTGTTGA TTACATCAAG 660 GCTGATGGAC AAAATATAGG ATGCAGATTT CCCTATTTGG AGGCATCAGA CTATAAAGAT 720 TTCTATATTT GTGTTAATGG ATCATCAGAG AACAAGCCTA TCAGATCCAG TTATTTCACT 780 TTTCAGCTTC AAAATATAGT TAAACCTTTG CCGCCAGTCT ATCTTACTTT TACTCGGGAG 840 AGTTCATGTG AAATTAAGCT GAAATGGAGC ATACCTTTGG GACCTATTCC AGCAAGGTGT 900 TTTGATTATG AAATTGAGAT CAGAGAAGAT GATACTACCT TGGTGACTGC TACAGTTGAA 960 AATGAAACAT ACACCTTGAA AACAACAAAT GAAACCCGAC AATTATGCTT TGTAGTAAGA 1020 AGCAAAGTGA ATATTTATTG CTCAGATGAC GGAATTTGGA GTGAGTGGAG TGATAAACAA 1080 TGCTGGGAAG GTGAAGACCT ATCGAAGAAA ACTTTGCTAC GTTTCTGGCT ACCATTTGGT 1140 TTCATCTTAA TATTAGTTAT ATTTGTAACC GGTCTGCTTT TGCGTAAGCC AAACACCTAC 1200 CCAAAAATGA TTCCAGAATT TTTCTGTGAT ACATGAAGAC TTTCCATATC AAGAGACATG 1260 GTATTGACTC AACAGTTTCC AGTCATGGCC AAATGTTCAA TATGAGTCTC AATAAACTGA 1320 ATTTTTCTTG CGAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 1380 AA Protein sequence 3 Gene name : interleukin 13 receptor, alpha 2 Unigene number : Hs. 25954 Probeset Accession # : R52795 Protein Accession # NP 000631 Signal sequence : 1-23 FN3 domain : 155-322 Transmembrane domains : 340-362 Cellular Localization : plasma membrane 1 11 21 31 41 51 MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY LQWQPPLSLD 60 HFKECTVEYE LKYRNIGSET NKTIITKMLH YKDGFDLNKG IEAKIHTLLP WQCTNGSEVQ 120 SSWAETTYWI SPQGIPETKV QDMDCVYYNW QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH 180 ALQCVDYIKA DGQNIGCRFP YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP 240 PVYLTFTRES SCEIKLKWSI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE 300 TRQLCFVVRS KVNIYCSDDG IWSEWSDKQC WEGEDLSKKT LLRFWLPFGF ILILVIFVTG 360 LLLRKPNTYP KMIPEFFCDT DNA sequence 4 Gene name : chemokine (C-X3-C) receptor 1 Unigene number : Hs. 78913 Probeset Accession # : U20350 Nucleic Acid Accession # : NM 001337 Coding sequence : 46-1113 1 11 21 31 41 51 GGGGCAGATC CAGATTCCCT TTGCAGTCCA CGCCAGGCCT TCACCATGGA TCAGTTCCCT 60 GAATCAGTGA CAGAAAACTT TGAGTACGAT GATTTGGCTG AGGCCTGTTA TATTGGGGAC 120 ATCGTGGTCT TTGGGACTGT GTTCCTGTCC ATATTCTACT CCGTCATCTT TGCCATTGGC 180 CTGGTGGGAA ATTTGTTGGT AGTGTTTGCC CTCACCAACA GCAAGAAGCC CAAGAGTGTC 240 ACCGACATTT ACCTCCTGAA CCTGGCCTTG TCTGATCTGC TGTTTGTAGC CACTTTGCCC 300 TTCTGGACTC ACTATTTGAT AAATGAAAAG GGCCTCCACA ATGCCATGTG CAAATTCACT 360 ACCGCCTTCT TCTTCATCGG CTTTTTTGGA AGCATATTCT TCATCACCGT CATCAGCATT 420 GATAGGTACC TGGCCATCGT CCTGGCCGCC AACTCCATGA ACAACCGGAC CGTGCAGCAT 480 GGCGTCACCA TCAGCCTAGG CGTCTGGGCA GCAGCCATTT TGGTGGCAGC ACCCCAGTTC 540 ATGTTCACAA AGCAGAAAGA AAATGAATGC CTTGGTGACT ACCCCGAGGT CCTTCAGGAA 600 ATCTGGCCCG TGCTCCGCAA TGTGGAAACA AATTTTCTTG GCTTCCTACT CCCCCTGCTC 660 ATTATGAGTT ATTGCTACTT CAGAATCATC CAGACGCTGT TTTCCTGCAA GAACCACAAG 720

AAAGCCAAAG CCATTAAACT GATCCTTCTG GTGGTCATCG TGTTTTTCCT CTTCTGGACA 780 CCCTACAACG TTATGATTTT CCTGGAGACG CTTAAGCTCT ATGACTTCTT TCCCAGTTGT 840 GACATGAGGA AGGATCTGAG GCTGGCCCTC AGTGTGACTG AGACGGTTGC ATTTAGCCAT 900 TGTTGCCTGA ATCCTCTCAT CTATGCATTT GCTGGGGAGA AGTTCAGAAG ATACCTTTAC 960 CACCTGTATG GGAAATGCCT GGCTGTCCTG TGTGGGCGCT CAGTCCACGT TGATTTCTCC 1020 TCATCTGAAT CACAAAGGAG CAGGCATGGA AGTGTTCTGA GCAGCAATTT TACTTACCAC 1080 ACGAGTGATG GAGATGCATT GCTCCTTCTC TGAAGGGAAT CCCAAAGCCT TGTGTCTACA 1140 GAGAACCTGG AGTTCCTGAA CCTGATGCTG ACTAGTGAGG AAGATTTTTG TTGTTATTTC 1200 TTACAGGCAC AAAATGATGG ACCCAATGCA CACAAAACAA CCCTAGAGTG TTGTTGAGAA 1260 TTGTGCTCAA AATTTGAAGA ATGAACAAAT TGAACTCTTT GAATGACAAA GAGTAGACAT 1320 TTCTCTTACT GCAAATGTCA TCAGAACTTT TTGGTTTGCA GATGACAAAA ATTCAACTCA 1380 GACTAGTTTA GTTAAATGAG GGTGGTGAAT ATTGTTCATA TTGTGGCACA AGCAAAAAGG 1440 GTGTCTGAGC CCTCAAAGTG AGGGGAACCA GGGCCTGAGC CAAGCTA Protein sequence 4 Gene name : chemokine (C-X3-C) receptor 1 Unigene number : Hs. 78913 Protein Accession # : NP 001328 Signal sequence : 1-44 Pfam domain : 7tm 1 [48-293] Cellular Localization : plasma membrane 1 11 21 31 41 51 MDQFPESVTE NFEYDDLAEA CYIGDIWFG TVFLSIFYSV IFAIGLVGNL LWFALTNSK 60 KPKSVTDIYL LNLALSDLLF VATLPFWTHY LINEKGLHNA MCKFTTAFFF IGFFGSIFFI 120 TVISIDRYLA IVLAANSMNN RTVQHGVTIS LGVWAAAILV AAPQFMFTKQ KENECLGDYP 180 EVLQEIWPVL RNVETNFLGF LLPLLIMSYC YFRIIQTLFS CKNHKKAKAI KLILLWIVF 240 FLFWTPYNVM IFLETLKLYD FFPSCDMRKD LRLALSVTET VAFSHCCLNP LIYAFAGEKF 300 RRYLYHLYGK CLAVLCGRSV HVDFSSSESQ RSRHGSVLSS NFTYHTSDGD ALLLL DNA sequence 5 Gene name : cannabinoid receptor 1 (brain) Unigene number : Hs. 75110 Probeset Accession # : 412986 Nucleic Acid Accession # : NM 001840 Coding sequence : 92-1510 1 11 21 31 41 51 TCGGCTTATT TGTTTTCCCT CCTCTTAGGA TTGCCCCCTG TGGGTCACTT TCTCAGTCAT 60 TTTGAGCTCA GCCTAATCAA AGACTGAGGT TATGAAGTCG ATCCTAGATG GCCTTGCAGA 120 TACCACCTTC CGCACCATCA CCACTGACCT CCTGTACGTG GGCTCAAATG ACATTCAGTA 180 CGAAGACATC AAAGGTGACA TGGCATCCAA ATTAGGGTAC TTCCCACAGA AATTCCCTTT 240 AACTTCCTTT AGGGGAAGTC CCTTCCAAGA GAAGATGACT GCGGGAGACA ACCCCCAGCT 300 AGTCCCAGCA GACCAGGTGA ACATTACAGA ATTTTACAAC AAGTCTCTCT CGTCCTTCAA 360 GGAGAATGAG GAGAACATCC AGTGTGGGGA GAACTTCATG GACATAGAGT GTTTCATGGT 420 CCTGAACCCC AGCCAGCAGC TGGCCATTGC AGTCCTGTCC CTCACGCTGG GCACCTTCAC 480 GGTCCTGGAG AACCTCCTGG TGCTGTGCGT CATCCTCCAC TCCCGCAGCC TCCGCTGCAG 540 GCCTTCCTAC CACTTCATCG GCAGCCTGGC GGTGGCAGAC CTCCTGGGGA GTGTCATTTT 600 TGTCTACAGC TTCATTGACT TCCACGTGTT CCACCGCAAA GATAGCCGCA ACGTGTTTCT 660 GTTCAAACTG GGTGGGGTCA CGGCCTCCTT CACTGCCTCC GTGGGCAGCC TGTTCCTCAC 720 AGCCATCGAC AGGTACATAT CCATTCACAG GCCCCTGGCC TATAAGAGGA TTGTCACCAG 780 GCCCAAGGCC GTGGTGGCGT TTTGCCTGAT GTGGACCATA GCCATTGTGA TCGCCGTGCT 840 GCCTCTCCTG GGCTGGAACT GCGAGAAACT GCAATCTGTT TGCTCAGACA TTTTCCCACA 900 CATTGATGAA ACCTACCTGA TGTTCTGGAT CGGGGTCACC AGCGTACTGC TTCTGTTCAT 960 CGTGTATGCG TACATGTATA TTCTCTGGAA GGCTCACAGC CACGCCGTCC GCATGATTCA 1020 GCGTGGCACC CAGAAGAGCA TCATCATCCA CACGTCTGAG GATGGGAAGG TACAGGTGAC 1080 CCGGCCAGAC CAAGCCCGCA TGGACATTAG GTTAGCCAAG ACCCTGGTCC TGATCCTGGT 1140 GGTGTTGATC ATCTGCTGGG GCCCTCTGCT TGCAATCATG GTGTATGATG TCTTTGGGAA 1200 GATGAACAAG CTCATTAAGA CGGTGTTTGC ATTCTGCAGT ATGCTCTGCC TGCTGAACTC 1260 CACCGTGAAC CCCATCATCT ATGCTCTGAG GAGTAAGGAC CTGCGACACG CTTTCCGGAG 1320 CATGTTTCCC TCTTGTGAAG GCACTGCGCA GCCTCTGGAT AACAGCATGG GGGACTCGGA 1380 CTGCCTGCAC AAACACGCAA ACAATGCAGC CAGTGTTCAC AGGGCCGCAG AAAGCTGCAT 1440 CAAGAGCACA GTCAAGATTG CCAAGGTAAC CATGTCTGTG TCCACAGACA CGTCTGCCGA 1500 GGCTCTGTGA GCCTGATGCC TCCCTGGCAG CACAGGAAAA GAATTTTTTT TTTTAAGCTC 1560 AAAATCTAGA AGAGTCTATT GTCTCCTTGG TTATATTTTT TTAACTTTAC CATGCTCAAT 1620 GAAAAGGTGA TTGTCACCAT GATCACTTAT CAGTTTGCTA ATGTTTCCAT AGTTTAGGTA 1680 CTCAAACTCC ATTCTCCAGG GGTTTACAGT GAAGAAAGCC TGTTGTTTAA GTGACTGAAC 1740 GATCCTTCAA AGTCTCAATG AAATAGGAGG GAAACCTTTG GCTACACAAT TGGAAGTCTA 1800 AGAACCCATG GAAAAATGCC ATCAAATGAA TAATGCCTTT GTAACCACAA CTTTCACTAT 1860 AATGTGAAAT GTAACTGTCC GTAGTATCAG AGATGTCCAT TTTTACAAGT TATAGTACTA 1920 GAGATATTTT GTAAAATGTA TTATGTCCTG TGAGATGTGT ATCAGTGTTT ATGTGCTATT 1980 AATATTTGTT TAGTTCAGCC AAACTGAAAG GTAGACTTTT ATGAGAACAA TGGACAAGCA 2040 GTGGATACGT GTCAATGTGT GCACTTTTTT TCTATATTAT TGCCCATGAT ATAACTTTAG 2100 AAATAAACCT TAATATTTCT TCCCAAAAAA AAAAA Protein sequence 5 Gene name : cannabinoid receptor 1 (brain) Unigene number : Hs. 75110 Protein Accession # : NP 001831 Signal sequence : none found Pfam domain : 7tm 1 [133-3971 Transmembrane domains : 121-143, 156-178, 195-217, 237-259, 276-298, 344-366, 378-400 Cellular Localization : plasma membrane 1 11 21 31 41 51

I I i I I I MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 60 KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA 120 VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF 180 HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAWAFCLM 240 WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK 300 AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR IAKTLVLILV VLIICWGPLL 360 AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ 420 PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL DNA sequence 6 Gene name : endothelin receptor type B Unigene number : Hs. 82002 Probeset Accession # : D13168 Nucleic Acid Accession # : NM 000115 Coding sequence : 238-1566 1 11 21 31 41 51 GAGACATTCC GGTGGGGGAC TCTGGCCAGC CCGAGCAACG TGGATCCTGA GAGCACTCCC 60 AGGTAGGCAT TTGCCCCGGT GGGACGCCTT GCCAGAGCAG TGTGTGGCAG GCCCCCGTGG 120 AGGATCAACA CAGTGGCTGA ACACTGGGAA GGAACTGGTA CTTGGAGTCT GGACATCTGA 180 AACTTGGCTC TGAAACTGCG CAGCGGCCAC CGGACGCCTT CTGGAGCAGG TAGCAGCATG 240 CAGCCGCCTC CAAGTCTGTG CGGACGCGCC CTGGTTGCGC TGGTTCTTGC CTGCGGCCTG 300 TCGCGGATCT GGGGAGAGGA GAGAGGCTTC CCGCCTGACA GGGCCACTCC GCTTTTGCAA 360 ACCGCAGAGA TAATGACGCC ACCCACTAAG ACCTTATGGC CCAAGGGTTC CAACGCCAGT 420 CTGGCGCGGT CGTTGGCACC TGCGGAGGTG CCTAAAGGAG ACAGGACGGC AGGATCTCCG 480 CCACGCACCA TCTCCCCTCC CCCGTGCCAA GGACCCATCG AGATCAAGGA GACTTTCAAA 540 TACATCAACA CGGTTGTGTC CTGCCTTGTG TTCGTGCTGG GGATCATCGG GAACTCCACA 600 CTTCTGAGAA TTATCTACAA GAACAAGTGC ATGCGAAACG GTCCCAATAT CTTGATCGCC 660 AGCTTGGCTC TGGGAGACCT GCTGCACATC GTCATTGACA TCCCTATCAA TGTCTACAAG 720 CTGCTGGCAG AGGACTGGCC ATTTGGAGCT GAGATGTGTA AGCTGGTGCC TTTCATACAG 780 AAAGCCTCCG TGGGAATCAC TGTGCTGAGT CTATGTGCTC TGAGTATTGA CAGATATCGA 840 GCTGTTGCTT CTTGGAGTAG AATTAAAGGA ATTGGGGTTC CAAAATGGAC AGCAGTAGAA 900 ATTGTTTTGA TTTGGGTGGT CTCTGTGGTT CTGGCTGTCC CTGAAGCCAT AGGTTTTGAT 960 ATAATTACGA TGGACTACAA AGGAAGTTAT CTGCGAATCT GCTTGCTTCA TCCCGTTCAG 1020 AAGACAGCTT TCATGCAGTT TTACAAGACA GCAAAAGATT GGTGGCTGTT CAGTTTCTAT 1080 TTCTGCTTGC CATTGGCCAT CACTGCATTT TTTTATACAC TAATGACCTG TGAAATGTTG 1140 AGAAAGAAAA GTGGCATGCA GATTGCTTTA AATGATCACC TAAAGCAGAG ACGGGAAGTG 1200 GCCAAAACCG TCTTTTGCCT GGTCCTTGTC TTTGCCCTCT GCTGGCTTCC CCTTCACCTC 1260 AGCAGGATTC TGAAGCTCAC TCTTTATAAT CAGAATGATC CCAATAGATG TGAACTTTTG 1320 AGCTTTCTGT TGGTATTGGA CTATATTGGT ATCAACATGG CTTCACTGAA TTCCTGCATT 1380 AACCCAATTG CTCTGTATTT GGTGAGCAAA AGATTCAAAA ACTGCTTTAA GTCATGCTTA 1440 TGCTGCTGGT GCCAGTCATT TGAAGAAAAA CAGTCCTTGG AGGAAAAGCA GTCGTGCTTA 1500 AAGTTCAAAG CTAATGATCA CGGATATGAC AACTTCCGTT CCAGTAATAA ATACAGCTCA 1560 TCTTGAAAGA AGAACTATTC ACTGTATTTC ATTTTCTTTA TATTGGACCG AAGTCATTAA 1620 AACAAAATGA AACATTTGCC AAAACAAAAC AAAAAACTAT GTATTTGCAC AGCACACTAT 1680 TAAAATATTA AGTGTAATTA TTTTAACACT CACAGCTACA TATGACATTT TATGAGCTGT 1740 TTACGGCATG GAAAGAAAAT CAGTGGGAAT TAAGAAAGCC TCGTCGTGAA AGCACTTAAT 1800 TTTTTACAGT TAGCACTTCA ACATAGCTCT TAACAACTTC CAGGATATTC ACACAACACT 1860 TAGGCTTAAA AATGAGCTCA CTCAGAATTT CTATTCTTTC TAAAAAGAGA TTTATTTTTA 1920 AATCAATGGG ACTCTGATAT AAAGGAAGAA TAAGTCACTG TAAAACAGAA CTTTTAAATG 1980 AAGCTTAAAT TACTCAATTT AAAATTTTAA AATCCTTTAA AACAACTTTT CAATTAATAT 2040 TATCACACTA TTATCAGATT GTAATTAGAT GCAAATGAGA GAGCAGTTTA GTTGTTGCAT 2100 TTTTCGGACA CTGGAAACAT TTAAATGATC AGGAGGGAGT AACAGAAAGA GCAAGGCTGT 2160 TTTTGAAAAT CATTACACTT TCACTAGAAG CCCAAACCTC AGCATTCTGC AATATGTAAC 2220 CAACATGTCA CAAACAAGCA GCATGTAACA GACTGGCACA TGTGCCAGCT GAATTTAAAA 2280 TATAATACTT TTAAAAAGAA AATTATTACA TCCTTTACAT TCAGTTAAGA TCAAACCTCA 2340 CAAAGAGAAA TAGAATGTTT GAAAGGCTAT CCCAAAAGAC TTTTTTGAAT CTGTCATTCA 2400 CATACCCTGT GAAGACAATA CTATCTACAA TTTTTTCAGG ATTATTAAAA TCTTCTTTTT 2460 TCACTATCGT AGCTTAAACT CTGTTTGGTT TTGTCATCTG TAAATACTTA CCTACATACA 2520 CTGCATGTAG ATGATTAAAT GAGGGCAGGC CCTGTGCTCA TAGCTTTACG ATGGAGAGAT 2580 GCCAGTGACC TCATAATAAA GACTGTGAAC TGCCTGGTGC AGTGTCCACA TGACAAAGGG 2640 GCAGGTAGCA CCCTCTCTCA CCCATGCTGT GGTTAAAATG GTTTCTAGCA TATGTATAAT 2700 GCTATAGTTA AAATACTATT TTTCAAAATC ATACAGATTA GTACATTTAA CAGCTACCTG 2760 TAAAGCTTAT TACTAATTTT TGTATTATTT TTGTAAATAG CCAATAGAAA AGTTTGCTTG 2820 ACATGGTGCT TTTCTTTCAT CTAGAGGCAA AACTGCTTTT TGAGACCGTA AGAACCTCTT 2880 AGCTTTGTGC GTTCCTGCCT AATTTTTATA TCTTCTAAGC AAAGTGCCTT AGGATAGCTT 2940 GGGATGAGAT GTGTGTGAAA GTATGTACAA GAGAAAACGG AAGAGAGAGG AAATGAGGTG 3000 GGGTTGGAGG AAACCCATGG GGACAGATTC CCATTCTTAG CCTAACGTTC GTCATTGCCT 3060 CGTCACATCA ATGCAAAAGG TCCTGATTTT GTTCCAGCAA AACACAGTGC AATGTTCTCA 3120 GAGTGACTTT CGAAATAAAT TGGGCCCAAG AGCTTTAACT CGGTCTTAAA ATATGCCCAA 3180 ATTTTTACTT TGTTTTTCTT TTAATAGGCT GGGCCACATG TTGGAAATAA GCTAGTAATG 3240 TTGTTTTCTG TCAATATTGA ATGTGATGGT ACAGTAAACC AAAACCCAAC AATGTGGCCA 3300 GAAAGAAAGA GCAATAATAA TTAATTCACA CACCATATGG ATTCTATTTA TAAATCACCC 3360 ACAAACTTGT TCTTTAATTT CATCCCAATC ACTTTTTCAG AGGCCTGTTA TCATAGAAGT 3420 CATTTTAGAC TCTCAATTTT AAATTAATTT TGAATCACTA ATATTTTCAC AGTTTATTAA 3480 TATATTTAAT TTCTATTTAA ATTTTAGATT ATTTTTATTA CCATGTACTG AATTTTTACA 3540 TCCTGATACC CTTTCCTTCT CCATGTCAGT ATCATGTTCT CTAATTATCT TGCCAAATTT 3600 TGAAACTACA CACAAAAAGC ATACTTGCAT TATTTATAAT AAAATTGCAT TCAGTGGCTT 3660 TTTAAAAAAA ATGTTTGATT CAAAACTTTA ACATACTGAT AAGTAAGAAA CAATTATAAT 3720 TTCTTTACAT ACTCAAAACC AAGATAGAAA AAGGTGCTAT CGTTCAACTT CAAAACATGT 3780 TTCCTAGTAT TAAGGACTTT AATATAGCAA CAGACAAAAT TATTGTTAAC ATGGATGTTA 3840 CAGCTCAAAA GATTTATAAA AGATTTTAAC CTATTTTCTC CCTTATTATC CACTGCTAAT 3900 GTGGATGTAT GTTCAAACAC CTTTTAGTAT TGATAGCTTA CATATGGCCA AAGGAATACA 3960

GTTTATAGCA AAACATGGGT ATGCTGTAGC TAACTTTATA AAAGTGTAAT ATAACAATGT 4020 AAAAAATTAT ATATCTGGGA GGATTTTTTG GTTGCCTAAA GTGGCTATAG TTACTGATTT 4080 TTTATTATGT AAGCAAAACC AATAAAAATT TAAGTTTTTT TAACAACTAC CTTATTTTTC 4140 ACTGTACAGA CACTAATTCA TTAAATACTA ATTGATTGTT TAAAAGAAAT ATAAATGTGA 4200 CAAGTGGACA TTATTTATGT TAAATATACA ATTATCAAGC AAGTATGAAG TTATTCAATT 4260 AAAATGCCAC ATTTCTGGTC TCTGGG Protein sequence 6 Gene name : endothelin receptor type B Unigene number : Hs. 82002 Protein Accession # : NP 000106 Signal sequence : 1-27 Pfam domain : 7tm 1 [118-386] Transmembrane domains : 100-122, 138-160, 173-195, 221-243, 277-299, 325-347, 358-380 Cellular Localization : plasma membrane 1 11 21 31 41 51 MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT KTLWPKGSNA 60 SLARSLAPAE VPKGDRTAGS PPRTISPPPC QGPIEIKETF KYINTWSCL VFVLGIIGNS 120 TLLRIIYKNK CMRNGPNILI ASLALGDLLH IVIDIPINVY KLLAEDWPFG AEMCKLVPFI 180 QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWWSV VLAVPEAIGF 240 DIITMDYKGS YLRICLLHPV QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM 300 LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY NQNDPNRCEL 360 LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQSFEE KQSLEEKQSC 420 LKFKANDHGY DNFRSSNKYS SS DNA sequence 7 Gene name : G protein-coupled receptor 34 Unigene number : Hs. 29202 Probeset Accession # : N54926 Nucleic Acid Accession # : AF039686 Coding sequence : 79-1224 1 11 21 31 41 51 AAAAACCTGA AGACATAAGA ACTACACATG AGGAATATGT CATTTAGCAC TTTCACTTTT 60 TGATCTCCAC AGAAGACAAT GAGAAGTCAT ACCATAACAA TGACGACAAC TTCAGTCAGC 120 AGCTGGCCTT ACTCCTCCCA CAGAATGCGC TTTATAACCA AT Q TAGCGA CCAACCGCCA 180 CAAAACTTCT CAGCAACACC AAATGTTACT ACCTGTCCCA TGGATGAAAA ATTGCTATCT 240 ACTGTGTTAA CCACATCCTA CTCTGTTATT TTCATCGTGG GACTGGTTGG GAACATAATC 300 GCCCTCTATG TATTTCTGGG TATTCACCGT AAAAGAAATT CCATTCAAAT TTATCTACTT 360 AACGTAGCCA TTGCAGACCT CCTACTCATC TTCTGCCTCC CTTTCCGAAT CATGTATCAT 420 ATTAACCAAA ACAAGTGGAC ACTAGGTGTG ATTCTGTGCA AGGTTGTGGG AACACTGTTT 480 TATATGAACA TGTACATTAG CATTATTTTG CTTGGATTCA TCAGTTTGGA TCGCTATATA 540 AAAATTAATC GGTCTATACA GCAACGGAAG GCAATAACAA CCAAACAAAG TATTTATGTC 600 TGTTGTATAG TATGGATGGT TGCTCTTGGT GGATTCCTAA CTATGATTAT TTTAACACTT 660 AAGAAAGGAG GGCATAATTC CACAATGTGT TTCCATTACA GAGATAAGCA TAACGCAAAA 720 GGAGAAGCCA TTTTTAACTT CATTCTTGTG GTAATGTTCT GGCTAATTTT CTTACTAATA 780 ATCCTTTCAT ATATTAAGAT TGGGAAGAAT CTATTGAGGA TTTCTAAAAG GAGGTCAAAA 840 TTTCCTAATT CTGGTAAATA TGCCACTACA GCTCGTAACT CCTTTATTGT ACTTATCATT 900 TTTACTATAT GTTTTGTTCC CTATCATGCC TTTCGATTCA TCTACATTTC TTCACAGCTA 960 AATGTATCAT CTTGCTACTG GAAAGAAATT GTTCACAAAA CCAATGAGAT CATGCTGGTT 1020 CTCTCATCTT TCAATAGTTG CTTAGATCCA GTCATGTATT TCCTGATGTC CAGTAACATT 1080 CGCAAAATAA TGTGCCAACT TCTTTTTAGA CGATTTCAAG GTGAACCAAG TAGGAGTGAA 1140 AGCACTTCAG AATTTAAACC AGGATACTCC CTGCATGATA CATCTGTGGC AGTGAAAATA 1200 CAGTCTAGTT CTAAAAGTAC TTGAGGTAAA CATACTAAAA TGAATTATAT AATGCAGCCT 1260 CTTAATTCTT TGAAGAACTA AAAAATTAGG AAACAAAGTT CTAGCATTTA CAAAACTCAG 1320 ATCTCAAAGC TCTGCTTGTA TTTGTGATAT TTCATTTGCT TAACTGTAAA CCAT Protein sequence 7 Gene name : G protein-coupled receptor 34 Unigene number : Hs. 29202 Protein Accession # : AAD50531 Signal sequence : none found Pfam domain : 7tm 1 [71-327] Transmembrane domains : 90-112, 126-148, 171-193, 217-239, 263-285 Cellular Localization : plasma membrane 1 11 21 31 41 51 MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE KLLSTVLTTS 60 YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD LLLIFCLPFR IMYHINQNKW 120 TLGVILCKW GTLFYMNMYI SIILLGFISL DRYIKINRSI QQRKAITTKQ SIYVCCIVWM 180 VALGGFLTMI ILTLKKGGHN STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK 240 IGKNLLRISK RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY 300 WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP SRSESTSEFK 360 PGYSLHDTSV AVKIQSSSKS T DNA SEQUENCE 8 Gene name : exostoses (multiple)-like 2 Unigene number : Hs. 61152 Nucleic Acid Accession # : NM 001439 Coding sequence : 288-1280 1 11 21 31 41 51 CACTTTGCGG GCGGCACTTT TTCCAGGTTG TTAATCCAGC TAATGGAGAA GGATAGATGC 60

ACGCTACTTG GTTTAGAAAA AAAAACAAAA ATGAGCAAAC GAGACGCCCC TTCCGTTTTA 120 TGATAACTAA GCTGCAGGGA AATAAATCGG CTGGCCCTAC TGCAATCTAC TGCACTCGAG 180 AAACATCACA GAAAATTCTT TGATTTATCT TAATAGTGAC AAGTGAGCCT GCTTCTGTCA 240 ATTACTGAAG CTATAAGGAG ATTTTTTAAA AATTAAACTT CAACACAATG AGGTGTTGCC 300 ACATCTGCAA ACTTCCTGGG AGAGTAATGG GGATTCGAGT GCTTCGATTA TCTTTGGTGG 360 TCATCCTCGT ATTATTACTG GTAGCTGGTG CTTTGACTGC CTTACTTCCC AGTGTTAAAG 420 AAGACAAGAT GCTCATGTTG CGTAGGGAAA TAAAATCCCA GGGCAAGTCC ACCATGGACT 480 CCTTTACTCT CATAATGCAG ACGTACAACA GAACAGATCT CTTATTGAAA CTTTTAAATC 540 ATTATCAGGC TGTACCAAAT CTGCACAAAG TGATTGTGGT ATGGAACAAT ATTGGAGAGA 600 AGGCACCAGA TGAATTATGG AATTCTCTAG GGCCCCACCC TATCCCTGTG ATCTTCAAAC 660 AACAGACAGC AAACAGGATG AGAAATCGAC TCCAGGTCTT TCCTGAACTG GAAACCAATG 720 CAGTGTTGAT GGTAGATGAT GACACACTCA TCAGCACCCC AGACCTTGTT TTTGCTTTCT 780 CAGTTTGGCA GCAATTTCCT GATCAAATTG TAGGATTTGT TCCTAGAAAG CACGTCTCTA 840 CTTCATCAGG TATCTACAGT TATGGAAGTT TTGAAATGCA AGCACCAGGG TCTGGAAATG 900 GTGACCAGTA CTCTATGGTG CTGATTGGAG CCTCATTCTT CAATAGCAAA TATCTTGAAT 960 TATTTCAGAG GCAACCTGCA GCTGTCCATG CTTTGATAGA TGATACTCAA AACTGTGATG 1020 ATATTGCCAT GAATTTTATC ATTGCCAAGC ATATTGGCAA GACTTCAGGG ATATTTGTGA 1080 AGCCTGTAAA CATGGACAAT TTGGAAAAAG AAACCAACAG TGGCTATTCT GGAATGTGGC 1140 ATCGAGCTGA GCACGCTCTG CAGAGGTCTT ATTGTATAAA TAAGCTTGTT AATATCTATG 1200 ATAGCATGCC CTTAAGATAC TCCAACATTA TGATTTCCCA GTTTGGTTTT CCATATGCCA 1260 ACTACAAAAG AAAAATATAA AAGTAAAACA AACAAAAACA AACCTGAAAA CTGCTTGGCA 1320 TTTGAGTAGC TTCTCCATGC TATGTATTTT TTTAAGCAAC ATCATGAATT TTATCTACTC 1380 CAGAAGTCTC TACAATAGAA AAAAAAGTGC AGTGCTTCTA GGATATAAAA TTCACATTAC 1440 TTTTGAAAGC CAAGAAGTTG GTCTTATCCA GTTAGGTCTT CTTATGAAGA GTTTTCATCC 1500 AGGGATATAA CTCCTTGGTC AGTGATTTTA TTGTTTACAT CCTGAGACTG TTCTACAGTT 1560 TCTTTGACTC CTGGCATTTG CCTTAAGGAC CTATAGCAAG CTGTTTCTAG GATCAGAAAC 1620 TCAAGAGAGG CATTTCTCTG CTTTTTCACT AAAGGTCAGT TGTTTTAATT TGAAACCTGA 1680 AATGCCTCTT TAGCAAAGCC TGTGGTATGG GGTAAAGCCA TGTAAGAAGA GAATAGTCTC 1740 AGTCACATAT GAAGAGGAAA ATTTGCAGCT GCCAGTGCTT TCCTTGTGGC CCTGCCAACC 1800 AGCTCTTCCA GGACGAACTC AGTCCAGCAT GGTTTTGATG TAACCATCCA TGCTTTTATT 1860 TTTGTTAAGT CTTTTGTGAC TGGGACAGTT AATTTTAGTA GCTGAAGAAC GTCTAGTTGT 1920 TTGCTTGATA TTTGTGAACA TTTACTGCAT GGATCACAAA ACAATATACC CTGTATTTCT 1980 TACACGCCAC TTATATGCAG CAAGGAGTAA ATGTGTTACT AGATTCGGGT AGTGCATTTT 2040 GTCACTGAAT CTGACCTTGA GAATGTACAT TAATTCTTAT ATTTTACATA ATGTATGTGT 2100 TGTTTAAGAA ATGTATAAAA AACCTGAAAA AAATGAGTAA GAACTGGCAG AAGTTAAAAC 2160 CCTTTGTATC AAAAGATCTT TATTGGTAGA GCACTGGTTA TCTTCTGGAT ACTAAAAAGT 2220 TGTATTACAA AGCCAAACAC TTGCATTCAC AACTTTAAAA AAAGATCCAA GGAACTATTC 2280 ATAATGATGA AATTTCAACT ACATACAAGG AGGAGAAAAT AAGAACCCAG TCATAACAGA 2340 GGAATTCTAT AGGAGTCTGC ATCAATTCAT TCTTAAGGTT GCCTACTCTC TGTTATGTGA 2400 ATTAGCGTCT GTGTTTCACC CATTGTCTGT GTTTAGTCCT TGTTCACCAC TAAGGCAAGG 2460 AATTCTTAAC TAGGCCTCTG TTTACCAACT TCTCTTTCTC CTCCTTTCCC TCTTATTCCT 2520 CCTTCTCCTC TTCCTTCTTA TATAATGCTA GTATATTCTC AAAATTGCAA AGCTGTGAGA 2580 ATATTAAAAT AATCATGGCT AATGTTCCAA TAATGAGGTC TTTGTGCATT TAGTTCCGCA 2640 TATGATGGTT TTTTTTTTAC ATTAAAGAGT ATATGTGTCT TAATGCAGTC AGATTGTAAA 2700 AAACAAAAAC AAAGAAACTA AGAATCTTAC TAAAAATCGA TAATGTCAGT TATCTGTTTT 2760 GTCCAATATT GGTAGTACTT TTTTGCCTCT TATGATTCCT CTAGCAGATA AATAAAAGAA 2820 ACTTTTGCCA TCC Protein sequence 8 Gene name : exostoses (multiple)-like 2 Unigene number : Hs. 61152 Protein Accession # : NP 001430 Signal sequence : 1-38 Transmembrane domains : none found Cellular Localization : plasma membrane 1 11 21 31 41 51 MRCCHICKLP GRVMGIRVLR LSLWILVLL LVAGALTALL PSVKEDKMLM LRREIKSQGK 60 STMDSFTLIM QTYNRTDLLL KLLNHYQAVP NLHKVIWWN NIGEKAPDEL WNSLGPHPIP 120 VIFKQQTANR MRNRLQVFPE LETNAVLMVD DDTLISTPDL VFAFSVWQQF PDQIVGFVPR 180 KHVSTSSGIY SYGSFEMQAP GSGNGDQYSM VLIGASFFNS KYLELFQRQP AAVHALIDDT 240 QNCDDIAMNF IIAKHIGKTS GIFVKPVNMD NLEKETNSGY SGMWHRAEHA LQRSYCINKL 300 VNIYDSMPLR YSNIMISQFG FPYANYKRKI DNA SEQUENCE 9 Gene name : Homo sapiens growth differentiation factor 1 (GDF1) Unigene number : Hs. 92614 Probeset Accession # : AL120193 Nucleic Acid Accession # : NM 021267 Coding sequence : 73-1125 1 11 21 31 41 51 ( ACGCGGGGCG CGCGGCTCCG TCGGCTACCG CGGGCGGGCG CAGGCGACGG GCACGGCGGG 60 CGAGCGGGCG GTATGGCGGC GGCGGGGCCC GCGGCGGGGC CGACGGGGCC CGAGCCCATG 120 CCGAGCTACG CGCAGCTAGT GCAGCGCGGC TGGGGCAGCG CGCTGGCGGC GGCGCGGGGC 180 TGCACGGACT GCGGCTGGGG GCTGGCGCGT CGCGGCCTGG CTGAGCACGC GCACCTGGCG 240 CCGCCCGAGC TGCTGCTGCT GGCGCTCGGC GCGCTGGGCT GGACCGCGCT GCGCTCCGCG 300 GCCACTGCGC GCCTCTTTCG GCCCCTGGCG AAGCGGTGCT GCCTCCAGCC CAGAGATGCC 360 GCCAAGATGC CCGAGAGCGC TTGGAAGTTT CTCTTCTACC TGGGCAGCTG GAGCTACAGT 420 GCCTACCTGC TGTTTGGCAC CGACTACCCC TTCTTCCATG ACCCACCATC TGTCTTCTAC 480 GACTGGACGC CGGGCATGGC AGTGCCACGG GACATTGCAG CCGCCTACCT GCTCCAGGGA 540 AGCTTCTATG GCCACTCCAT CTACGCTACG CTATACATGG ACACCTGGCG CAAGGACTCG 600 GTGGTCATGC TGCTCCACCA CGTGGTCACT CTCATCCTCA TCGTCTCCTC CTACGCCTTC 660 CGGTACCACA ATGTGGGCAT CCTTGTGCTC TTCCTGCACG ATATCAGTGA CGTGCAGCTT 720

GAGTTCACCA AGCTCAACAT TTACTTCAAG TCCCGCGGCG GCTCCTACCA TCGGCTGCAT 780 GCCTTGGCAG CAGACTTGGG CTGCCTCAGC TTCGGCTTCA GCTGGTTCTG GTTCCGCCTC 840 TACTGGTTCC CGCTCAAGGT CCTGTATGCC ACCAGTCACT GCAGTCTGCG CACGGTGCCT 900 GACATCCCCT TCTACTTCTT CTTCAATGCG CTCCTGCTGC TGCTCACCCT TATGAACCTC 960 TACTGGTTCC TGTACATCGT GGCGTTTGCA GCCAAGGTGT TGACAGGCCA GGTGCACGAG 1020 CTGAAGGACC TGCGGGAGTA TGACACAGCC GAGGCCCAGA GCCTGAAGCC CAGCAAAGCC 1080 GAGAAGCCAC TGAGGAACGG CCTGGTGAAG GACAAGCGCT TCTGAACCCC TCGGCCCCGC 1140 CCCCGTGGAC CCGGCCCCAC CCCGAATACC CCGGCCACGC TCCCCGTCCT TGGCCGCCCC 1200 TCCACCCCCT CCAACTCTGC TCCTCTAGGG CCGCCGCCAC CTCCCCTGGG ACCCCGCCCC 1260 CTCATCCTGC CTCCATTTCC CGGCCACGCC CCCCAGGACC CCTGCCCCTC CGGGGACACC 1320 GGCCCCGCCC TCAGCCCACT GGTCCCGGGC CGCCGCGGAC CCTGCGCACT CTCTGGTCAT 1380 CGCCTGGGAG GAAGATGCCA CCGCCGCAGC AAGGTCCCTG CGGCCACCAC CTCCTCCTCC 1440 TCCTGGCCCT GCTGCTGCCC TCGCTGCCCC TGACCCGCGC CCCCGTGCCC CCAGGCCCAG 1500 CCGCCGCCCT GCTCCAGGCT CTAGGACTGC GCGATGAGCC CCAGGGTGCC CCCAGGCTCC 1560 GGCCGGTTCC CCCGGTCATG TGGCGCCTGT TTCGACGCCG GGACCCCCAG GAGACCAGGT 1620 CTGGCTCGCG GCGGACGTCC CCAGGGGTCA CCCTGCAACC GTGCCACGTG GAGGAGCTGG 1680 GGGTCGCCGG AAACATCGTG CGCCACATCC CGGACCGCGG TGCGCCCACC CGGGCCTCGG 1740 AGCCTGTCTC GGCCGCGGGG CATTGCCCTG AGTGGACAGT CGTCTTCGAC CTGTCGGCTG 1800 TGGAACCCGC TGAGCGCCCG AGCCGGGCCC GCCTGGAGCT GCGTTTCGCG GCGGCGGCGG 1860 CGGCAGCCCC GGAGGGCGGC TGGGAGCTGA GCGTGGCGCA AGCGGGCCAG GGCGCGGGCG 1920 CGGACCCCGG GCCGGTGCTG CTCCGCCAGT TGGTGCCCGC CCTGGGGCCG CCAGTGCGCG 1980 CGGAGCTGCT GGGCGCCGCT TGGGCTCGCA ACGCCTCATG GCCGCGCAGC CTCCGCCTGG 2040 CGCTGGCGCT ACGCCCCCGG GCCCCTGCCG CCTGCGCGCG CCTGGCCGAG GCCTCGCTGC 2100 TGCTGGTGAC CCTCGACCCG CGCCTGTGCC ACCCCCTGGC CCGGCCGCGG CGCGACGCCG 2160 AACCCGTGTT GGGCGGCGGC CCCGGGGGCG CTTGTCGCGC GCGGCGGCTG TACGTGAGCT 2220 TCCGCGAGGT GGGCTGGCAC CGCTGGGTCA TCGCGCCGCG CGGCTTCCTG GCCAACTACT 2280 GCCAGGGTCA GTGCGCGCTG CCCGTCGCGC TGTCGGGGTC CGGGGGGCCG CCGGCGCTCA 2340 ACCACGCTGT GCTGCGCGCG CTCATGCACG CGGCCGCCCC GGGAGCCGCC GACCTGCCCT 2400 GCTGCGTGCC CGCGCGCCTG TCGCCCATCT CCGTGCTCTT CTTTGACAAC AGCGACAACG 2460 TGGTGCTGCG GCAGTATGAG GACATGGTGG TGGACGAGTG CGGCTGCCGC TAACCCGGGG Protein sequence 9 Gene name : Homo sapiens growth differentiation factor 1 (GDF1) Unigene number : Hs. 92614 Protein Accession # : NP 067090 Signal sequence : none found Transmembrane domains : 106-128, 148-169, 184-206, 244-266, 285-307 Cellular Localization : plasma membrane 1 11 21 31 41 51 I I I I I I MAAAGPAAGP TGPEPMPSYA QLVQRGWGSA LAAARGCTDC GWGLARRGLA EHAHLAPPEL 60 LLLALGALGW TALRSAATAR LFRPLAKRCC LQPRDAAKMP ESAWKFLFYL GSWSYSAYLL 120 FGTDYPFFHD PPSVFYDWTP GMAVPRDIAA AYLLQGSFYG HSIYATLYMD TWRKDSWML 180 LHHWTLILI VSSYAFRYHN VGILVLFLHD ISDVQLEFTK LNIYFKSRGG SYHRLHALAA 240 DLGCLSFGFS WFWFRLYWFP LKVLYATSHC SLRTVPDIPF YFFFNALLLL LTLMNLYWFL 300 YIVAFAAKVL TGQVHELKDL REYDTAEAQS LKPSKAEKPL RNGLVKDKRF DNA SEQUENCE 10 Gene name : epidermal growth factor receptor (avian erythroblastic leukemia Unigene number : Hs. 77432 Nucleic Acid Accession # : NM 005228 Coding sequence : 187-3819 1 11 21 31 41 51 GCCGCGCTGC GCCGGAGTCC CGAGCTAGCC CCGGCGCCGC CGCCGCCCAG ACCGGACGAC 60 AGGCCACCTC GTCGGCGTCC GCCCGAGTCC CCGCCTCGCC GCCAACGCCA CAACCACCGC 120 GCACGGCCCC CTGACTCCGT CCAGTATTGA TCGGGAGAGC CGGAGCGAGC TCTTCGGGGA 180 GCAGCGATGC GACCCTCCGG GACGGCCGGG GCAGCGCTCC TGGCGCTGCT GGCTGCGCTC 240 TGCCCGGCGA GTCGGGCTCT GGAGGAAAAG AAAGTTTGCC AAGGCACGAG TAACAAGCTC 300 AGGCAGTTGG GCACTTTTGA AGATCATTTT CTCAGCCTCC AGAGGATGTT CAATAACTGT 360 GAGGTGGTCC TTGGGAATTT GGAAATTACC TATGTGCAGA GGAATTATGA TCTTTCCTTC 420 TTAAAGACCA TCCAGGAGGT GGCTGGTTAT GTCCTCATTG CCCTCAACAC AGTGGAGCGA 480 ATTCCTTTGG AAAACCTGCA GATCATCAGA GGAAATATGT ACTACGAAAA TTCCTATGCC 540 TTAGCAGTCT TATCTAACTA TGATGCAAAT AAAACCGGAC TGAAGGAGCT GCCCATGAGA 600 AATTTACAGG AAATCCTGCA TGGCGCCGTG CGGTTCAGCA ACAACCCTGC CCTGTGCAAC 660 GTGGAGAGCA TCCAGTGGCG GGACATAGTC AGCAGTGACT TTCTCAGCAA CATGTCGATG 720 GACTTCCAGA ACCACCTGGG CAGCTGCCAA AAGTGTGATC CAAGCTGTCC CAATGGGAGC 780 TGCTGGGGTG CAGGAGAGGA GAACTGCCAG AAACTGACCA AAATCATCTG TGCCCAGCAG 840 TGCTCCGGGC GCTGCCGTGG CAAGTCCCCC AGTGACTGCT GCCACAACCA GTGTGCTGCA 900 GGCTGCACAG GCCCCCGGGA GAGCGACTGC CTGGTCTGCC GCAAATTCCG AGACGAAGCC 960 ACGTGCAAGG ACACCTGCCC CCCACTCATG CTCTACAACC CCACCACGTA CCAGATGGAT 1020 GTGAACCCCG AGGGCAAATA CAGCTTTGGT GCCACCTGCG TGAAGAAGTG TCCCCGTAAT 1080 TATGTGGTGA CAGATCACGG CTCGTGCGTC CGAGCCTGTG GGGCCGACAG CTATGAGATG 1140 GAGGAAGACG GCGTCCGCAA GTGTAAGAAG TGCGAAGGGC CTTGCCGCAA AGTGTGTAAC 1200 GGAATAGGTA TTGGTGAATT TAAAGACTCA CTCTCCATAA ATGCTACGAA TATTAAACAC 1260 TTCAAAAACT GCACCTCCAT CAGTGGCGAT CTCCACATCC TGCCGGTGGC ATTTAGGGGT 1320 GACTCCTTCA CACATACTCC TCCTCTGGAT CCACAGGAAC TGGATATTCT GAAAACCGTA 1380 AAGGAAATCA CAGGGTTTTT GCTGATTCAG GCTTGGCCTG AAAACAGGAC GGACCTCCAT 1440 GCCTTTGAGA ACCTAGAAAT CATACGCGGC AGGACCAAGC AACATGGTCA GTTTTCTCTT 1500 GCAGTCGTCA GCCTGAACAT AACATCCTTG GGATTACGCT CCCTCAAGGA GATAAGTGAT 1560 GGAGATGTGA TAATTTCAGG AAACAAAAAT TTGTGCTATG CAAATACAAT AAACTGGAAA 1620 AAACTGTTTG GGACCTCCGG TCAGAAAACC AAAATTATAA GCAACAGAGG TGAAAACAGC 1680 TGCAAGGCCA CAGGCCAGGT CTGCCATGCC TTGTGCTCCC CCGAGGGCTG CTGGGGCCCG 1740 GAGCCCAGGG ACTGCGTCTC TTGCCGGAAT GTCAGCCGAG GCAGGGAATG CGTGGACAAG 1800

TGCAAGCTTC TGGAGGGTGA GCCAAGGGAG TTTGTGGAGA ACTCTGAGTG CATACAGTGC 1860 CACCCAGAGT GCCTGCCTCA GGCCATGAAC ATCACCTGCA CAGGACGGGG ACCAGACAAC 1920 TGTATCCAGT GTGCCCACTA CATTGACGGC CCCCACTGCG TCAAGACCTG CCCGGCAGGA 1980 GTCATGGGAG AAAACAACAC CCTGGTCTGG AAGTACGCAG ACGCCGGCCA TGTGTGCCAC 2040 CTGTGCCATC CAAACTGCAC CTACGGATGC ACTGGGCCAG GTCTTGAAGG CTGTCCAACG 2100 AATGGGCCTA AGATCCCGTC CATCGCCACT GGGATGGTGG GGGCCCTCCT CTTGCTGCTG 2160 GTGGTGGCCC TGGGGATCGG CCTCTTCATG CGAAGGCGCC ACATCGTTCG GAAGCGCACG 2220 CTGCGGAGGC TGCTGCAGGA GAGGGAGCTT GTGGAGCCTC TTACACCCAG TGGAGAAGCT 2280 CCCAACCAAG CTCTCTTGAG GATCTTGAAG GAAACTGAAT TCAAAAAGAT CAAAGTGCTG 2340 GGCTCCGGTG CGTTCGGCAC GGTGTATAAG GGACTCTGGA TCCCAGAAGG TGAGAAAGTT 2400 AAAATTCCCG TCGCTATCAA GGAATTAAGA GAAGCAACAT CTCCGAAAGC CAACAAGGAA 2460 ATCCTCGATG AAGCCTACGT GATGGCCAGC GTGGACAACC CCCACGTGTG CCGCCTGCTG 2520 GGCATCTGCC TCACCTCCAC CGTGCAACTC ATCACGCAGC TCATGCCCTT CGGCTGCCTC 2580 CTGGACTATG TCCGGGAACA CAAAGACAAT ATTGGCTCCC AGTACCTGCT CAACTGGTGT 2640 GTGCAGATCG CAAAGGGCAT GAACTACTTG GAGGACCGTC GCTTGGTGCA CCGCGACCTG 2700 GCAGCCAGGA ACGTACTGGT GAAAACACCG CAGCATGTCA AGATCACAGA TTTTGGGCTG 2760 GCCAAACTGC TGGGTGCGGA AGAGAAAGAA TACCATGCAG AAGGAGGCAA AGTGCCTATC 2820 AAGTGGATGG CATTGGAATC AATTTTACAC AGAATCTATA CCCACCAGAG TGATGTCTGG 2880 AGCTACGGGG TGACCGTTTG GGAGTTGATG ACCTTTGGAT CCAAGCCATA TGACGGAATC 2940 CCTGCCAGCG AGATCTCCTC CATCCTGGAG AAAGGAGAAC GCCTCCCTCA GCCACCCATA 3000 TGTACCATCG ATGTCTACAT GATCATGGTC AAGTGCTGGA TGATAGACGC AGATAGTCGC 3060 CCAAAGTTCC GTGAGTTGAT CATCGAATTC TCCAAAATGG CCCGAGACCC CCAGCGCTAC 3120 CTTGTCATTC AGGGGGATGA AAGAATGCAT TTGCCAAGTC CTACAGACTC CAACTTCTAC 3180 CGTGCCCTGA TGGATGAAGA AGACATGGAC GACGTGGTGG ATGCCGACGA GTACCTCATC 3240 CCACAGCAGG GCTTCTTCAG CAGCCCCTCC ACGTCACGGA CTCCCCTCCT GAGCTCTCTG 3300 AGTGCAACCA GCAACAATTC CACCGTGGCT TGCATTGATA GAAATGGGCT GCAAAGCTGT 3360 CCCATCAAGG AAGACAGCTT CTTGCAGCGA TACAGCTCAG ACCCCACAGG CGCCTTGACT 3420 GAGGACAGCA TAGACGACAC CTTCCTCCCA GTGCCTGAAT ACATAAACCA GTCCGTTCCC 3480 AAAAGGCCCG CTGGCTCTGT GCAGAATCCT GTCTATCACA ATCAGCCTCT GAACCCCGCG 3540 CCCAGCAGAG ACCCACACTA CCAGGACCCC CACAGCACTG CAGTGGGCAA CCCCGAGTAT 3600 CTCAACACTG TCCAGCCCAC CTGTGTCAAC AGCACATTCG ACAGCCCTGC CCACTGGGCC 3660 CAGAAAGGCA GCCACCAAAT TAGCCTGGAC AACCCTGACT ACCAGCAGGA CTTCTTTCCC 3720 AAGGAAGCCA AGCCAAATGG CATCTTTAAG GGCTCCACAG CTGAAAATGC AGAATACCTA 3780 AGGGTCGCGC CACAAAGCAG TGAATTTATT GGAGCATGAC CACGGAGGAT AGTATGAGCC 3840 CTAAAAATCC AGACTCTTTC GATACCCAGG ACCAAGCCAC AGCAGGTCCT CCATCCCAAC 3900 AGCCATGCCC GCATTAGCTC TTAGACCCAC AGACTGGTTT TGCAACGTTT ACACCGACTA 3960 GCCAGGAAGT ACTTCCACCT CGGGCACATT TTGGGAAGTT GCATTCCTTT GTCTTCAAAC 4020 TGTGAAGCAT TTACAGAAAC GCATCCAGCA AGAATATTGT CCCTTTGAGC AGAAATTTAT 4080 CTTTCAAAGA GGTATATTTG AAAAAAAAAA AAAAAGTATA TGTGAGGATT TTTATTGATT 4140 GGGGATCTTG GAGTTTTTCA TTGTCGCTAT TGATTTTTAC TTCAATGGGC TCTTCCAACA 4200 AGGAAGAAGC TTGCTGGTAG CACTTGCTAC CCTGAGTTCA TCCAGGCCCA ACTGTGAGCA 4260 AGGAGCACAA GCCACAAGTC TTCCAGAGGA TGCTTGATTC CAGTGGTTCT GCTTCAAGGC 4320 TTCCACTGCA AAACACTAAA GATCCAAGAA GGCCTTCATG GCCCCAGCAG GCCGGATCGG 4380 TACTGTATCA AGTCATGGCA GGTACAGTAG GATAAGCCAC TCTGTCCCTT CCTGGGCAAA 4440 GAAGAAACGG AGGGGATGAA TTCTTCCTTA GACTTACTTT TGTAAAAATG TCCCCACGGT 4500 ACTTACTCCC CACTGATGGA CCAGTGGTTT CCAGTCATGA GCGTTAGACT GACTTGTTTG 4560 TCTTCCATTC CATTGTTTTG AAACTCAGTA TGCCGCCCCT GTCTTGCTGT CATGAAATCA 4620 GCAAGAGAGG ATGACACATC AAATAATAAC TCGGATTCCA GCCCACATTG GATTCATCAG 4680 CATTTGGACC AATAGCCCAC AGCTGAGAAT GTGGAATACC TAAGGATAAC ACCGCTTTTG 4740 TTCTCGCAAA AACGTATCTC CTAATTTGAG GCTCAGATGA AATGCATCAG GTCCTTTGGG 4800 GCATAGATCA GAAGACTACA AAAATGAAGC TGCTCTGAAA TCTCCTTTAG CCATCACCCC 4860 AACCCCCCAA AATTAGTTTG TGTTACTTAT GGAAGATAGT TTTCTCCTTT TACTTCACTT 4920 CAAAAGCTTT TTACTCAAAG AGTATATGTT CCCTCCAGGT CAGCTGCCCC CAAACCCCCT 4980 CCTTACGCTT TGTCACACAA AAAGTGTCTC TGCCTTGAGT CATCTATTCA AGCACTTACA 5040 GCTCTGGCCA CAACAGGGCA TTTTACAGGT GCGAATGACA GTAGCATTAT GAGTAGTGTG 5100 AATTCAGGTA GTAAATATGA AACTAGGGTT TGAAATTGAT AATGCTTTCA CAACATTTGC 5160 AGATGTTTTA GAAGGAAAAA AGTTCCTTCC TAAAATAATT TCTCTACAAT TGGAAGATTG 5220 GAAGATTCAG CTAGTTAGGA GCCCATTTTT TCCTAATCTG TGTGTGCCCT GTAACCTGAC 5280 TGGTTAACAG CAGTCCTTTG TAAACAGTGT TTTAAACTCT CCTAGTCAAT ATCCACCCCA 5340 TCCAATTTAT CAAGGAAGAA ATGGTTCAGA AAATATTTTC AGCCTACAGT TATGTTCAGT 5400 CACACACACA TACAAAATGT TCCTTTTGCT TTTAAAGTAA TTTTTGACTC CCAGATCAGT 5460 CAGAGCCCCT ACAGCATTGT TAAGAAAGTA TTTGATTTTT GTCTCAATGA AAATAAAACT 5520 ATATTCATTT CC Protein sequence 10 Gene name : epidermal growth factor receptor (avian erythroblastic leukemia Unigene number : Hs. 77432 Protein Accession # : NP 005219 Signal sequence : 1-27 Pfam domain : Recep L domain [57-190, 372-492] Transmembrane domains : 646-668 1 11 21 31 41 51 MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 60 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 120 VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF 180 QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 240 TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300 VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK 360 NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF 420 ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL 480 FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCK 540 LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM 600 GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLW 660

ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 720 GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 780 CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 840 RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 900 GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 960 FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ 1020 QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED 1080 SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN 1140 TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV 1200 APQSSEFIGA DNA sequence 11 Genename : claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) Unigene number : Hs. 110903 Probeset Accession # : AW245805 Nucleic Acid Accession # : NM 003277 Coding sequence : 121-777 1 11 21 31 41 51 I I I I I I AGGGGACTGG GGCCAAGAGC CGGGAGCGCG GGCGCAAAGG CACCAGGGCC CGCCCAGGGC 60 GCCGCGCAGC ACGGCCTTGG GGGTTCTGCG GGCCTTCGGG TGCGCGTCTC GCCTCTAGCC 120 ATGGGGTCCG CAGCGTTGGA GATCCTGGGC CTGGTGCTGT GCCTGGTGGG CTGGGGGGGT 180 CTGATCCTGG CGTGCGGGCT GCCCATGTGG CAGGTGACCG CCTTCCTGGA CCACAACATC 240 GTGACGGCGC AGACCACCTG GAAGGGCCTG TGGATGTCGT GCGTGGTGCA GAGCACCGGG 300 CACATGCAGT GCAAAGTGTA CGACTCGGTG CTGGCTCTGA GCACCGAGGT GCAGGCGGCG 360 CGGGCGCTCA CCGTGAGCGC CGTGCTGCTG GCGTTCGTTG CGCTCTTCGT GACCCTGGCG 420 GGCGCGCAGT GCACCACCTG CGTGGCCCCG GGCCCGGCCA AGGCGCGTGT GGCCCTCACG 480 GGAGGCGTGC TCTACCTGTT TTGCGGGCTG CTGGCGCTCG TGCCACTCTG CTGGTTCGCC 540 AACATTGTCG TCCGCGAGTT TTACGACCCG TCTGTGCCCG TGTCGCAGAA GTACGAGCTG 600 GGCGCAGCGC TGTACATCGG CTGGGCGGCC ACCGCGCTGC TCATGGTAGG CGGCTGCCTC 660 TTGTGCTGCG GCGCCTGGGT CTGCACCGGC CGTCCCGACC TCAGCTTCCC CGTGAAGTAC 720 TCAGCGCCGC GGCGGCCCAC GGCCACCGGC GACTACGACA AGAAGAACTA CGTCTGAGGG 780 CGCTGGGCAC GGCCGGGCCC CTCCTGCCAG CCACGCCTGC GAGGCGTTGG ATAAGCCTGG 840 GGAGCCCCGC ATGGACCGCG GCTTCCGCCG GGTAGCGCGG CGCGCAGGCT CCTCGGAACG 900 TCCGGCTCTG CGCCCCGACG CGGCTCCTGG ATCCGCTCCT GCCTGCGCCC GCAGCTGACC 960 TTCTCCTGCC ACTAGCCCGG CCCTGCCCTT AACAGACGGA ATGAAGTTTC CTTTTCTGTG 1020 CGCGGCGCTG TTTCCATAGG CAGAGCGGGT GTCAGACTGA GGATTTCGCT TCCCCTCCAA 1080 GACGCTGGGG GTCTTGGCTG CTGCCTTACT TCCCAGAGGC TCCTGCTGAC TTCGGAGGGG 1140 CGGATGCAGA GCCCGGGGCC CCCACCGGAA GATGTGTACA GCTGGTCTTT ACTCCATCGG 1200 CAGGCCCGAG CCCAGGGACC AGTGACTTGG CCTGGACCTC CCGGTCTCAC TCCAGCATCT 1260 CCCCAGGCAA GGCTTGTGGG CACCGGAGCT TGAGAGAGGG CGGGAGTGGG AAGGCTAAGA 1320 ATCTGCTTAG Protein sequence 11 Gene name : claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) Unigene number : Hs. 110903 Protein Accession # : NP 003268 Signal sequence : none found Pfam domain : PMP22 Claudin [4-181] Transmembrane domains : 5-27, 74-96, 123-145, 164-186 Cellular Localization : plasma membrane 1 11 21 31 41 51 MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCWQSTG 60 HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA GAQCTTCVAP GPAKARVALT 120 GGVLYLFCGL LALVPLCWFA NIWREFYDP SVPVSQKYEL GAALYIGWAA TALLMVGGCL 180 LCCGAWVCTG RPDLSFPVKY SAPRRPTATG DYDKKNYV DNA sequence 12 Gene name : vascular endothelial junction-associated molecule Unigene number : Hs. 54650 Probeset Accession # : AA410345 Nucleic Acid Accession # : AF255910 Coding sequence : 241-1137 1 11 21 31 41 51 TTACCATTGT GTTGGGCTGC GAGAAGACGA CAGAAGGGGG ACCCGCCTCT TGGCAGCCAG 60 CTGAGAAGGC GCCCCGGGGA GGGGGAAACT GACATCCCAT CTAGAGCCGT CCCTCCTCTT 120 CCTCCCCTCC CGACTCTCTG CTCCTTTCCC GCCCCAGAAG TTCAAGGGCC CCCGGCCTCC 180 TGCGCTCCTG CCGCCGGGAC CCTCGACCTC CTCAGAGCAG CCGGCTGCCG CCCCGGGAAG 240 ATGGCGAGGA GGAGCCGCCA CCGCCTCCTC CTGCTGCTGC TGCGCTACCT GGTGGTCGCC 300 CTGGGCTATC ATAAGGCCTA TGGGTTTTCT GCCCCAAAAG ACCAACAGGT AGTCACAGCA 360 GTAGAGTACC AAGAGGCTAT TTTAGCCTGC AAAACCCCAA AGAAGACTGT TTCCTCCAGA 420 TTAGAGTGGA AGAAACTGGG TCGGAGTGTC TCCTTTGTCT ACTATCAACA GACTCTTCAA 480 GGTGATTTTA AAAATCGAGC TGAGATGATA GATTTCAATA TCCGGATCAA AAATGTGACA 540 AGAAGTGATG CGGGGAAATA TCGTTGTGAA GTTAGTGCCC CATCTGAGCA AGGCCAAAAC 600 CTGGAAGAGG ATACAGTCAC TCTGGAAGTA TTAGTGGCTC CAGCAGTTCC ATCATGTGAA 660 GTACCCTCTT CTGCTCTGAG TGGAACTGTG GTAGAGCTAC GATGTCAAGA CAAAGAAGGG 720 AATCCAGCTC CTGAATACAC ATGGTTTAAG GATGGCATCC GTTTGCTAGA AAATCCCAGA 780 CTTGGCTCCC AAAGCACCAA CAGCTCATAC ACAATGAATA CAAAAACTGG AACTCTGCAA 840 TTTAATACTG TTTCCAAACT GGACACTGGA GAATATTCCT GTGAAGCCCG CAATTCTGTT 900 GGATATCGCA GGTGTCCTGG GAAACGAATG CAAGTAGATG ATCTCAACAT AAGTGGCATC 960 ATAGCAGCCG TAGTAGTTGT GGCCTTAGTG ATTTCCGTTT GTGGCCTTGG TGTATGCTAT 1020

GCTCAGAGGA AAGGCTACTT TTCAAAAGAA ACCTCCTTCC AGAAGAGTAA TTCTTCATCT 1080 AAAGCCACGA CAATGAGTGA AAATGATTTC AAGCACACAA AATCCTTTAT AATTTAAAGA 1140 CTCCACTTTA GAGATACACC AAAGCCACCG TTGTTACACA AGTTATTAAA CTATTATAAA 1200 ACTCTGCTTT GTCCGACATT TGCAAAGAGG TACACGAGGA AATGGAATTG GTATTTCATT 1260 TTAATTTTCA TGACTACTAA CTCACCTGAA CTTGCTATTT TAAAMAAATA GTTCTGTCGA 1320 CACCTAAAAT ATAATCTGGC TTCTTGTGTC TGGACTAAGT TAAAAGAATT AAAATACTTT 1380 GTAATGTCAA AAAAAAA Protein sequence 12 Gene name : vascular endothelial junction-associated molecule Unigene number : Hs. 54650 Protein Accession # : AAF81223 Signal sequence : 1-22 Igc2 domain : 41-116, 146-221 Transmembrane domains : 239-261 Cellular Localization : plasma membrane 1 11 21 31 41 51 I I I I I I MARRSRHRLL LLLLRYLWA LGYHKAYGFS APKDQQWTA VEYQEAILAC KTPKKTVSSR 60 LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT RSDAGKYRCE VSAPSEQGQN 120 LEEDTVTLEV LVAPAVPSCE VPSSALSGTV VELRCQDKEG NPAPEYTWFK DGIRLLENPR 180 LGSQSTNSSY TMNTKTGTLQ FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI 240 IAAVWVALV ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII DNA sequence 13 Gene name : solute carrier family 11 (proton-coupled divalent metal ion Unigene number : Hs. 182611 Probeset Accession # : D50402 Nucleic Acid Accession # : NM 000578 Coding sequence : 1-1653 1 11 21 31 41 51 ATGACAGGTG ACAAGGGTCC CCAAAGGCTA AGCGGGTCCA GCTATGGTTC CATCTCCAGC 60 CCGACCAGCC CGACCAGCCC AGGGCCACAG CAAGCACCTC CCAGAGAGAC CTACCTGAGT 120 GAGAAGATCC CCATCCCAGA CACAAAACCG GGCACCTTCA GGCTGCGGAA GCTATGGGCC 180 TTCACGGGGC CTGGCTTCCT CATGAGCATT GCTTTCCTGG ACCCAGGAAA CATCGAGTCA 240 GATCTTCAGC TNGGNCCNGT GGCGGGATTC AAACTTCTCT GGGTGCTGCT CTGGGCCACC 300 GTGTTGGGCT TGCTCTGCCA GCGACTGGCT GCACGTCTGG GCGTGGTGAC AGGCAAGGAC 360 TTGGGCGAGG TCTGCCATCT CTACTACCCT AAGGTGCCCC GCACCGTCCT CTGGCTGACC 420 ATCGAGCTAG CCATTGTGGG CTCCGACATG CAGGAAGTCA TCGGCACGGC CATTGCATTC 480 AATCTGCTCT CAGCTGGACG AATCCCACTC TGGGGTGGCG TCCTCATCAC CATCGTGGAC 540 ACCTTCTTCT TCCTCTTCCT CGATAACTAC GGGCTGCGGA AGCTGGAAGC TTTTTTTGGA 600 CTCCTTATAA CCATTATGGC CTTGACCTTT GGCTATGAGT ATGTGGTGGC GCGTCCTGAG 660 CAGGGAGCGC TTCTTCGGGG CCTGTTCCTG CCCTCGTGCC CGGGCTGCGG CCACCCCGAG 720 CTGCTGCAGG CGGTGGGCAT TGTTGGCGCC ATCATCATGC CCCACAACAT CTACCTGCAC 780 TCGGCCCTGG TCAAGTCTCG AGAGATAGAC CGGGCCCGCC GAGTCGACAT CAGAGAAGCC 840 AACATGTACT TCCTGATTGA GGCCACCATC GCCCTGTCCG TCTCCTTTAT CATCAACCTC 900 TTTGTCATGG CTGCATTTGG GCAGGCCTTC TACCAGAAAA CCAAGCAGGC TGCGTTCAAC 960 ATCTGTGCCA ACAGCAGCCT CCACGACTAC GCTAAGATCT TCCCCATGAA CAACGCCACC 1020 GTGGCCGTGG ACATTTACCA GGGGGGCGTG ATCCTGGGCT GCCTGTTCGG CCCCGCGGCC 1080 CTCTACATCT GGGCCATAGG TCTCCTGGCG GCTGGGCAGA GCTCCACCAT GACGGGCACC 1140 TACGCGGGAC AGTTCGTGAT GGAGGGCTTC CTGAGGCTGC GGTGGTCAAG CTTCGCCCGT 1200 GTCCTCCTCA CCCGCTCCTG CGCCATCCTG CCCACCGTGC TCGTGGCTGT CTTCCGGGAC 1260 CTGAGGGACT TGTCGGGCCT CAATGATCTG CTCAACGTGC TGCAGAGCCT GCTGCTCCCG 1320 GTTGCCGTGC TGCCCATCCT CACGTTCACC AGCATGCCCA CCCTCATGCA GGAGTTTGCC 1380 AATGGCCTGC TGAACAAGGT CGTCACCTCT TCCATCATGG TGCTAGTCTG CACCATCAAC 1440 CTCTACTTCG TGGTCAGCTA TCTGCCCAGC CTGCCCCACC CTGCCTACTT CGGCCTTGCA 1500 GCCTTGCTGG CCGCAGCCTA CCTGGGCCTC AGCACCTACC TGGTCTGGAC CTGTTGCCTT 1560 GCCCACGGAG CCACCTTTCT GGCCCACAGC TCCCACCACC ACTTCCTGTA TGGGCTCCTT 1620 GAAGAGGACC ACAAAGGGGA GACCTCTGGC TAG Protein sequence 13 Gene name : solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Unigene number : Hs. 182611 Protein Accession # : NP 000569 Signal sequence : none found Pfam domain : Nramp [78-463] Transmembrane domains : 58-80, 88-110, 159-181, 195-217, 284-306, 349-379, 394-416, 432-454, 468-490, 501-523 Cellular Localization : plasma membrane 1 11 21 31 41 51 MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP GTFRLRKLWA 60 FTGPGFLMSI AFLDPGNIES DLQLGPVAGF KLLWVLLWAT VLGLLCQRLA ARLGWTGKD 120 LGEVCHLYYP KVPRTVLWLT IELAIVGSDM QEVIGTAIAF NLLSAGRIPL WGGVLITIVD 180 TFFFLFLDNY GLRKLEAFFG LLITIMALTF GYEYWARPE QGALLRGLFL PSCPGCGHPE 240 LLQAVGIVGA IIMPHNIYLH SALVKSREID RARRVDIREA NMYFLIEATI ALSVSFIINL 300 FVMAAFGQAF YQKTKQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV ILGCLFGPAA 360 LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSSFAR VLLTRSCAIL PTVLVAVFRD 420 LRDLSGLNDL LNVLQSLLLP VAVLPILTFT SMPTLMQEFA NGLLNKWTS SIMVLVCTIN 480 LYFWSYLPS LPHPAYFGLA ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHEFLYGLL 540 EEDHKGETSG DNA sequence 14 Gene name : solute carrier family 7 (cationic amino acid transporter, y+

Unigene number : Hs. 184601 Probeset Accession # : AF104032 Nucleic Acid Accession # : NM 003486 Coding sequence : 53-1576 1 11 21 31 41 51 GCTCGCTGGG CCGCTGCTCC CGGGTGTCCC AGGCCCGGCC GGTGCGCAGA GCATGGCGGG 60 TGCGGGCCCG AAGCGGCGCG CGCTAGCGGC GCCGGCGGCC GAGGAGAAGG AAGAGGCGCG 120 GGAGAAGATG CTGGCCGCCA AGAGCGCGGA CGGCTCGGCG CCGGCAGGCG AGGGCGAGGG 180 CGTGACCCTG CAGCGGAACA TCACGCTGCT CAACGGCGTG GCCATCATCG TGGGGACCAT 240 TATCGGCTCG GGCATCTTCG TGACGCCCAC GGGCGTGCTC AAGGAGGCAG GCTCGCCGGG 300 GCTGGCGCTG GTGGTGTGGG CCGCGTGCGG CGTCTTCTCC ATCGTGGGCG CGCTCTGCTA 360 CGCGGAGCTC GGCACCACCA TCTCCAAATC GGGCGGCGAC TACGCCTACA TGCTGGAGGT 420 CTACGGCTCG CTGCCCGCCT TCCTCAAGCT CTGGATCGAG CTGCTCATCA TCCGGCCTTC 480 ATCGCAGTAC ATCGTGGCCC TGGTCTTCGC CACCTACCTG CTCAAGCCGC TCTTCCCCAC 540 CTGCCCGGTG CCCGAGGAGG CAGCCAAGCT CGTGGCCTGC CTGTGCGTGC TGCTGCTCAC 600 GGCCGTGAAC TGCTACAGCG TGAAGGCCGC CACCCGGGTC CAGGATGCCT TTGCCGCCGC 660 CAAGCTCCTG GCCCTGGCCC TGATCATCCT GCTGGGCTTC GTCCAGATCG GAAAGGGTGA 720 TGTGTCCAAT CTAGATCCCA AGTTCTCATT TGAAGGCACC AAACTGGATG TGGGGAACAT 780 TGTGCTGGCA TTATACAGCG GCCTCTTTGC CTATGGAGGA TGGAATTACT TGAATTTCGT 840 CACAGAGGAA ATGATCAACC CCTACAGAAA CCTGCCCCTG GCCATCATCA TCTCCCTGCC 900 CATCGTGACG CTGGTGTACG TGCTGACCAA CCTGGCCTAC TTCACCACCC TGTCCACCGA 960 GCAGATGCTG TCGTCCGAGG CCGTGGCCGT GGACTTCGGG AACTATCACC TGGGCGTCAT 1020 GTCCTGGATC ATCCCCGTCT TCGTGGGCCT GTCCTGCTTT GGCTCCGTCA ATGGGTCCCT 1080 GTTCACATCC TCCAGGCTCT TCTTCGTGGG GTCCCGGGAA GGCCACCTGC CCTCCATCCT 1140 CTCCATGATC CACCCACAGC TCCTCACCCC CGTGCCGTCC CTCGTGTTCA CGTGTGTGAT 1200 GACGCTGCTC TACGCCTTCT CCAAGGACAT CTTCTCCGTC ATCAACTTCT TCAGCTTCTT 1260 CAACTGGCTC TGCGTGGCCC TGGCCATCAT CGGCATGATC TGGCTGCGCC ACAGAAAGCC 1320 TGAGCTTGAG CGGCCCATCA AGGTGAACCT GGCCCTGCCT GTGTTCTTCA TCCTGGCCTG 1380 CCTCTTCCTG ATCGCCGTCT CCTTCTGGAA GACACCCGTG GAGTGTGGCA TCGGCTTCAC 1440 CATCATCCTC AGCGGGCTGC CCGTCTACTT CTTCGGGGTC TGGTGGAAAA ACAAGCCCAA 1500 GTGGCTCCTC CAGGGCATCT TCTCCACGAC CGTCCTGTGT CAGAAGCTCA TGCAGGTGGT 1560 CCCCCAGGAG ACATAGCCAG GAGGCCGAGT GGCTGCCGGA GGAGCATGC Protein sequence 14 Gene name : solute carrier family 7 (cationic amino acid transporter, y+ Unigene number : Hs. 184601 Protein Accession # : NP 003477 Pfam domain : aa permeases [46-481] Transmembrane domains : 52-74, 82-104, 120-142, 145-167, 169-191, 200-222, 237-259, 275-297, 323-345, 371-393, 398-419, 430-452, 455-476 Cellular Localization : plasma membrane 1 11 21 31 41 51 MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV 60 GTIIGSGIFV TPTGVLKEAG SPGLALWWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM 120 LEVYGSLPAF LKLWIELLII RPSSQYIVAL VFATYLLKPL FPTCPVPEEA AKLVACLCVL 180 LLTAVNCYSV KAATRVQDAF AAAKLLALAL IILLGFVQIG KGDVSNLDPK FSFEGTKLDV 240 GNIVLALYSG LFAYGGWNYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL 300 STEQMLSSEA VAVDFGNYHL GVMSWIIPVF VGLSCFGSVN GSLFTSSRLF FVGSREGHLP 360 SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF SFFNWLCVAL AIIGMIWLRH 420 RKPELERPIK VNLALPVFFI LACLFLIAVS FWKTPVECGI GFTIILSGLP VYFFGVWWKN 480 KPKWLLQGIF STTVLCQKLM QWPQET DNA sequence 15 Gene name : Glutamate receptor subunit Unigene number : Hs. 249141 Nucleic Acid Accession # : S40369 Coding sequence : 1-2943 1. 11 21 31 41 51 ATGCCGGCTG AGCTGCTGCT GCTGCTGATT GTTGCCTTCG CCAGCCCCAG CTGCCAGGTG 60 CTCTCATCAC TGCGCATGGC TGCAATCCTG GATGATCAGA CAGTGTGTGG CCGCGGTGAG 120 CGTCTGGCCT TGGCCTTGGC CCGGGAGCAG ATCAACGGGA TCATCGAGGT CCCAGCCAAG 180 GCCCGAGTGG AAGTAGACAT CTTTGAGCTG CAGCGGGACA GCCAGTACGA GACCACGGAC 240 ACCATGTGTC AGATCTTACC CAAAGGGGTT GTGTCTGTCC TTGGGCCCTC CTCTAGCCCA 300 GCATCTGCCT CCACCGTGAG CCATATCTGT GGAGAGAAGG AGATCCCCCA CATCAAGGTG 360 GGTCCCGAGG AGACACCCCG CCTTCAGTAC CTTCGCTTCG CGTCTGTCAG CCTGTACCCC 420 AGTAACGAGG ACGTCAGCTT GGCGGTCTCC CGAATCCTCA AGTCCTTCAA CTACCCCTCG 480 GCCAGCCTCA TCTGCGCCAA GGCTGAGTGC CTGCTGCGAT TGGAGGAACT GGTGCGTGGC 540 TTCCTCATCT CCAAGGAGAC GCTGTCAGTG AGGATGTTGG ACGACAGCCG GGACCCCACA 600 CCACTGCTCA AGGAGATCCG TGATGACAAG GTGTCCACCA TCATCATCGA CGCCAACGCC 660 TCCATCTCCC ACCTCATCCT CCGTAAGGCC TCGGAACTGG GAATGACCTC AGCGTTTTAC 720 AAGTACATCC TCACCACCAT GGACTTCCCC ATCCTGCATC TGGACGGTAT TGTGGAGGAC 780 TCCTCCAACA TCCTGGGCTT CTCCATGTTC AACACGTCCC ACCCCTTCTA CCCTGAGTTT 840 GTCCGCAGCC TCAACATGTC CTGGAGGGAG AACTGTGAAG CCAGCACCTA CCTGGGCCCT 900 GCGCTGTCAG CCGCCCTGAT GTTTGACGCC GTGCACGTGG TGGTGAGCGC TGTCCGAGAG 960 CTGAACCGCA GCCAGGAGAT CGGTGTGAAG CCTCTGGCCT GTACATCGGC CAACATTTGG 1020 CCCCACGGGA CCAGCCTCAT GAACTACCTG CGCATGGTAG AGTATGATGG GCTGACCGGG 1080 CGGGTCGAGT TCAACAGCAA AGGGCAGAGA ACCAACTACA CCCTGCGCAT CCTAGAAAAG 1140 TCCCGGCAGG GCCACCGTGA GATTGGGGTG TGGTACTCTA ACCGCACCCT GGCCATGAAT 1200 GCCACCACCC TGGACATCAA CCTGTCGCAG ACACTGGCCA ACAAGACCCT GGTGGTCACA 1260 ACCATCCTGG AGAACCCATA CGTCATGCGC CGGCCCAACT TCCAGGGCCT GTCGGGGAAC 1320 GAACGCTTCG AGGGCTTCTG CGTGGACATG CTGCGGGAGC TGGCCGAGCT GCTGCCGTTC 1380

CCGTACCGCC TGCGGTTGGT GGAGGATGGG CTGTACGGGG CGCCCGAGCC CAACGGCTCC 1440 TGGACGGGCA TGGTTGGCGA GCTCATCAAC CGGAAGGCAG ACCTGGCTGT GGCCGCCTTC 1500 ACCATCACAG CTGAGCGGGA GAAGGTCATC GACTTTTCCA AGCCCTTTAT GACCCTGGGG 1560 ATCAGCATCC TCTACCGAGT GCACATGGGC CGCAAGCCTG GCTACTTCTC CTTCCTGGAC 1620 CCCTTCTCCC CTGCTGTGTG GCTCTTCATG CTTCTTGCCT ACCTGGCTGT CAGCTGCGTC 1680 CTGTTTCTGG CTGCCAGGCT GAGCCCCTAT GAGTGGTATA ACCCACACCC ATGCCTGCGG 1740 GCACGCCCCC ACATCCTGGA GAACCAGTAC ACGCTGGGCA ACAGCCTGTG GTTTCCCGTG 1800 GGGGGCTTCA TGCAGCAGGG CTCGGAGATC ATGCCCCGGG CGCTGTCCAC GCGCTGTGTC 1860 AGCGGAGTCT GGTGGGCCTT CACCTTGATC ATCATCTCCT CCTACACGGC CAACCTGGCC 1920 GCCTTCCTCA CCGTGCAGCG CATGGAGGTG CCTGTGGAGT CGGCCGATGA CCTGGCAGAT 1980 CAGACCAACA TCGAGTATGG CACCATCCAC GCCGGCTCCA CCATGACCTT CTTCCAGAAT 2040 TCACGGTACC AAACGTACCA GCGCATGTGG AACTACATGC AGTCGAAGCA GCCCAGCGTG 2100 TTCGTCAAGA GCACAGAAGA GGGCATTGCC GCCGTCCTCA ACTCCCGCTA CGCCTTCCTG 2160 CTCGAGTCCA CCATGAACGA ATACCACCGG CGCCTCAACT GCAACCTCAC CCAGATCGGG 2220 GGACTCCTCG ACACCAAGGG CTACGGCATT GGCATGCCGC TGGGCTCCCC GTTCCGGGAT 2280 GAGATCACAC TGGCCATCCT GCAGCTTCAG GAGAACAACC GGCTGGAGAT CCTGAAGCGC 2340 AAGTGGTGGG AGGGGGGCCG GTGCCCCAAG GAGGAGGACC ATCGAGCTAA AGGTTTGGGC 2400 ATGGAGAACA TTGGTGGCAT TTTTATCGTG CTCATCTGTG GCCTCATCAT TGCTGTCTTC 2460 GTGGCGGTCA TGGAATTCAT ATGGTCCACA CGGAGGTCAG CTGAGTCCGA GGAGGTGTCG 2520 GTGTGCCAGG AGATGCTGCA GGAGCTGCGC CACGCCGTTT CTTGCCGCAA GACGTCGCGT 2580 TCCCGCCGGC GCCGACGCCC GGGCGGCCCG AGCCGGGCCC TGCTGTCACT GCGCGCGGTC 2640 CGCGAGATGC GCCTCAGCAA CGGCAAGCTC TACTCGGCCG GCGCGGGCGG GGATGCGGGC 2700 AGCGCGCACG GGGGCCCGCA GCGCCTCCTG GACGACCCGG GGCCCCCCAG CGGAGCCCGA 2760 CCCGCCGCCC CCACCCCCTG CACCCACGTG CGCGTCTGCC AGGAGTGCCG GCGCATCCAG 2820 GCGCTGCGGG CCTCGGGGGC CGGCGCGCCT CCGCGTGGCC TGGGCGTCCC CGCCGAAGCC 2880 ACCAGCCCGC CCCGGCCGCG GCCTGGCCCC GCCGGCCCCC GGGAGCTGGC GGAGCACGAG 2940 TGA Protein sequence 15 Gene name : Glutamate receptor subunit Unigene number : Hs. 249141 Protein Accession # : AAB22591 Signal sequence : 1-27 Pfam domain : ANF receptor [343-400] ; PBPe domain [416-785, 799-838] Transmembrane domains : 297-319, 544-566, 624-646, 803-825 Cellular Localization : plasma membrane 1 11 21 31 41 51 MPAELLLLLI VAFASPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ INGIIEVPAK 60 ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP ASASTVSHIC GEKEIPHIKV 120 GPEETPRLQY LRFASVSLYP SNEDVSLAVS RILKSFNYPS ASLICAKAEC LLRLEELVRG 180 FLISKETLSV RMLDDSRDPT PLLKEIRDDK VSTIIIDANA SISHLILRKA SELGMTSAFY 240 KYILTTMDFP ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYLGP 300 ALSAALMFDA VHVWSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL RMVEYDGLTG 360 RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN ATTLDINLSQ TLANKTLWT 420 TILENPYVMR RPNFQGLSGN ERFEGFCVDM LRELAELLPF PYRLRLVEDG LYGAPEPNGS 480 WTGMVGELIN RKADLAVAAF TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD 540 PFSPAVWLFM LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 600 GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV PVESADDLAD 660 QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV FVKSTEEGIA AVLNSRYAFL 720 LESTMNEYHR RLNCNLTQIG GLLDTKGYGI GMPLGSPFRD EITLAILQLQ ENNRLEILKR 780 KWWEGGRCPK EEDHRAKGLG MENIGGIFIV LICGLIIAVF VAVMEFIWST RRSAESEEVS 840 VCQEMLQELR HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 900 SAHGGPQRLL DDPGPPSGAR PAAPTPCTHV RVCQECRRIQ ALRASGAGAP PRGLGVPAEA 960 TSPPRPRPGP AGPRELAEHE DNA sequence 16 Gene name : adenosine A3 receptor Unigene number : Hs. 258 Probeset Accession # : NM 000677 Nucleic Acid Accession # : NM 000677 Coding sequence : 768-1724 1 11 21 31 41 51 I I I I I I ATCTTTGCTG CAAAGGCTGG GTATCGGCTG TGCTCAGCAA AGCGTCAACT CGTGCAAGAA 60 CTTAGCAGGA ATAGTTCTGG CTAAGGTTAG GAGGCTGCCA CCAAAGTCTC TTTTTTGTTC 120 CTCTGCTTCT CCCGTTTGCC TCCTTATCAT GAGATCTTTT TGCTAAGCTG GCAGAAAGAT 180 TGCATAGTCA GTGCTTCCAG CTCTGCTCCC ACCTGATCCT GCACTGTCCT CTGGTCCCTG 240 AATGAATGAA CTCTGATACC CAATCTTGTC TCGAGCCTTC TCTATGCCAC TCATGGCTCC 300 TCTTCTGCTC TTTCCATCTT TTTGCTGAGA GTTCTGAGCT CTGTACTTCC TCTTGGCCCA 360 TCTCACTTCC TGAAACACCC CTGAAGAGGG TTGCTTATCT TGATGGAACT CAAAAAGCCA 420 AAAAGCTGCA GGCAGAGGCG TTGAGGACAT CTGTTTGGGG AACTAAGAGC AGCAGCACTT 480 TCAGATTCAG TCCATATAGA GCTGTCCTAC AGCATTCTGG AAACTTGAGG ATGTGCGGTG 540 CATAAAGGGG CTGGAAGTGA CCCACCTGTG ATGAGCCCTT TCTAAGGAGA AGGGTTTCCA 600 AGAGATCACC CCACCAGAAA AGGGTAGGAA TGAGCAAGTT GGGAATTTTA GACTGTCACT 660 GCACATGGAC CTCTGGGAAG ACGTCTGGCG AGAGCTAGGC CCACTGGCCC TACAGACGGA 720 TCTTGCTGGC TCACCTGTCC CTGTGGAGGT TCCCCTGGGA AGGCAAGATG CCCAACAACA 780 GCACTGCTCT GTCATTGGCC AATGTTACCT ACATCACCAT GGAAATTTTC ATTGGACTCT 840 GCGCCATAGT GGGCAACGTG CTGGTCATCT GCGTGGTCAA GCTGAACCCC AGCCTGCAGA 900 CCACCACCTT CTATTTCATT GTCTCTCTAG CCCTGGCTGA CATTGCTGTT GGGGTGCTGG 960 TCATGCCTTT GGCCATTGTT GTCAGCCTGG GCATCACAAT CCACTTCTAC AGCTGCCTTT 1020 TTATGACTTG CCTACTGCTT ATCTTTACCC ACGCCTCCAT CATGTCCTTG CTGGCCATCG 1080 CTGTGGACCG ATACTTGCGG GTCAAGCTTA CCGTCAGATA CAAGAGGGTC ACCACTCACA 1140 GAAGAATATG GCTGGCCCTG GGCCTTTGCT GGCTGGTGTC ATTCCTGGTG GGATTGACCC 1200

CCATGTTTGG CTGGAACATG AAACTGACCT CAGAGTACCA CAGAAATGTC ACCTTCCTTT 1260 CATGCCAATT TGTTTCCGTC ATGAGAATGG ACTACATGGT ATACTTCAGC TTCCTCACCT 1320 GGATTTTCAT CCCCCTGGTT GTCATGTGCG CCATCTATCT TGACATCTTT TACATCATTC 1380 GGAACAAACT CAGTCTGAAC TTATCTAACT CCAAAGAGAC AGGTGCATTT TATGGACGGG 1440 AGTTCAAGAC GGCTAAGTCC TTGTTTCTGG TTCTTTTCTT GTTTGCTCTG TCATGGCTGC 1500 CTTTATCTAT CATCAACTGC ATCATCTACT TTAATGGTGA GGTACCACAG CTTGTGCTGT 1560 ACATGGGCAT CCTGCTGTCC CATGCCAACT CCATGATGAA CCCTATCGTC TATGCCTATA 1620 AAATAAAGAA GTTCAAGGAA ACCTACCTTT TGATCCTCAA AGCCTGTGTG GTCTGCCATC 1680 CCTCTGATTC TTTGGACACA AGCATTGAGA AGAATTCTGA GTAGTTATCC ATCAGAGATG 1740 ACTCTGTCTC ATTGACCTTC AGATTCCCCA TCAACAAACA CTTGAGGGCC TGTATGCCTG 1800 GGCCAAGGGA TTTTTACATC CTTGATTACT TCCACTGAGG TGGGAGCATC TCCAGTGCTC 1860 CCCAATTATA TCTCCCCCAC TCCACTACTC TCTTCCTCCA CTTCATTTTT CCTTTGTCCT 1920 TTCTCTCTAA TTCAGTGTTT TGGAGGCCTG ACTTGGGGAC AACGTATTAT TGATATTATT 1980 GTCTGTTTTC CTTCTTCCCA ATAGAAGAAT AAGTCATGGA GCCTGAAGGG TGCCTAGTTG 2040 ACTTACTGAC AAAAGGCTCT AGTTGGGCTG AACATGTGTG TGGTGGTGAC TCATTTCCAT 2100 GCCATTGTGG AATTGAGCAG AGAACCTGCT CTCGGAGGAT GCCTAGAAGA TGTTGGGAAC 2160 AGAAGAAATA AACTGAGTTT AAGGGGGACT TAAACTGCTG AATTCACCTG TGGATGTTTT 2220 TGAGTAAATA AAAGCTAATA G Protein sequence 16 Gene name : adenosine A3 receptor Unigene number : Hs. 258 Protein Accession # : NP 000668 Signal sequence : none found Pfam domain : 7tm 1 [29-282] Transmembrane domains : 12-34, 50-72, 86-108, 120-150, 179-201, 229-251 Cellular Localization : plasma membrane 1 11 21 31 41 51 MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICWKLN PSLQTTTFYF IVSLALADIA 60 VGVLVMPLAI WSLGITIHF YSCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYKR 120 VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF 180 SFLTWIFIPL WMCAIYLDI FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA 240 LSWLPLSIIN CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC 300 WCHPSDSLD TSIEKNSE DNA sequence 17 Gene name : glypican 1 Unigene number : Hs. 2699 Probeset Accession # : X54232 Nucleic Acid Accession # : NM 002081 Coding sequence : 222-1898 1 11 21 31 41 51 GGCTGCCCGA GCGAGCGTTC GGACCTCGCA CCCCGCGCGC CCCGCGCCGC CGCCGCCGCC 60 GGCTTTTGTT GTCTCCGCCT CCTCGGCCGC CGCCGCCTCT GGACCGCGAG CCGCGCGCGC 120 CGGGACCTTG GCTCTGCCCT TCGCGGGCGG GAACTGCGCA GGACCCGGCC AGGATCCGAG 180 AGAGGCGCGG GCGGGTGGCC GGGGGCGCCG CCGGCCCCGC CATGGAGCTC CGGGCCCGAG 240 GCTGGTGGCT GCTATGTGCG GCCGCAGCGC TGGTCGCCTG CGCCCGCGGG GACCCGGCCA 300 GCAAGAGCCG GAGCTGCGGC GAGGTCCGCC AGATCTACGG AGCCAAGGGC TTCAGCCTGA 360 GCGACGTGCC CCAGGCGGAG ATCTCGGGTG AGCACCTGCG GATCTGTCCC CAGGGCTACA 420 CCTGCTGCAC CAGCGAGATG GAGGAGAACC TGGCCAACCG CAGCCATGCC GAGCTGGAGA 480 CCGCGCTCCG GGACAGCAGC CGCGTCCTGC AGGCCATGCT TGCCACCCAG CTGCGCAGCT 540 TCGATGACCA CTTCCAGCAC CTGCTGAACG ACTCGGAGCG GACGCTGCAG GCCACCTTCC 600 CCGGCGCCTT CGGAGAGCTG TACACGCAGA ACGCGAGGGC CTTCCGGGAC CTGTACTCAG 660 AGCTGCGCCT GTACTACCGC GGTGCCAACC TGCACCTGGA GGAGACGCTG GCCGAGTTCT 720 GGGCCCGCCT GCTCGAGCGC CTCTTCAAGC AGCTGCACCC CCAGCTGCTG CTGCCTGATG 780 ACTACCTGGA CTGCCTGGGC AAGCAGGCCG AGGCGCTGCG GCCCTTCGGG GAGGCCCCGA 840 GAGAGCTGCG CCTGCGGGCC ACCCGTGCCT TCGTGGCTGC TCGCTCCTTT GTGCAGGGCC 900 TGGGCGTGGC CAGCGACGTG GTCCGGAAAG TGGCTCAGGT CCCCCTGGGC CCGGAGTGCT 960 CGAGAGCTGT CATGAAGCTG GTCTACTGTG CTCACTGCCT GGGAGTCCCC GGCGCCAGGC 1020 CCTGCCCTGA CTATTGCCGA AATGTGCTCA AGGGCTGCCT TGCCAACCAG GCCGACCTGG 1080 ACGCCGAGTG GAGGAACCTC CTGGACTCCA TGGTGCTCAT CACCGACAAG TTCTGGGGTA 1140 CATCGGGTGT GGAGAGTGTC ATCGGCAGCG TGCACACGTG GCTGGCGGAG GCCATCAACG 1200 CCCTCCAGGA CAACAGGGAC ACGCTCACGG CCAAGGTCAT CCAGGGCTGC GGGAACCCCA 1260 AGGTCAACCC CCAGGGCCCT GGGCCTGAGG AGAAGCGGCG CCGGGGCAAG CTGGCCCCGC 1320 GGGAGAGGCC ACCTTCAGGC ACGCTGGAGA AGCTGGTCTC TGAAGCCAAG GCCCAGCTCC 1380 GCGACGTCCA GGACTTCTGG ATCAGCCTCC CAGGGACACT GTGCAGTGAG AAGATGGCCC 1440 TGAGCACTGC CAGTGATGAC CGCTGCTGGA ACGGGATGGC CAGAGGCCGG TACCTCCCCG 1500 AGGTCATGGG TGACGGCCTG GCCAACCAGA TCAACAACCC CGAGGTGGAG GTGGACATCA 1560 CCAAGCCGGA CATGACCATC CGGCAGCAGA TCATGCAGCT GAAGATCATG ACCAACCGGC 1620 TGCGCAGCGC CTACAACGGC AACGACGTGG ACTTCCAGGA CGCCAGTGAC GACGGCAGCG 1680 GCTCGGGCAG CGGTGATGGC TGTCTGGATG ACCTCTGCGG CCGGAAGGTC AGCAGGAAGA 1740 GCTCCAGCTC CCGGACGCCC TTGACCCATG CCCTCCCAGG CCTGTCAGAG CAGGAAGGAC 1800 AGAAGACCTC GGCTGCCAGC TGCCCCCAGC CCCCGACCTT CCTCCTGCCC CTCCTCCTCT 1860 TCCTGGCCCT TACAGTAGCC AGGCCCCGGT GGCGGTAACT GCCCCAAGGC CCCAGGGACA 1920 GAGGCCAAGG ACTGACTTTG CCAAAAATAC AACACAGACG ATATTTAATT CACCTCAGCC 1980 TGGAGAGGCC TGGGGTGGGA CAGGGAGGGC CGGCGGCTCT GAGCAGGGGC AGGCGCAGAG 2040 GTCCCAGCCC CAGGCCTGGC CTCGCCTGCC TTTCTGCCTT TTAATTTTGT ATGAGGTCCT 2100 CAGGTCAGCT GGGAGCCAGT GTGCCCAAAA GCCATGTATT TCAGGGACCT CAGGGGCACC 2160 TCCGGCTGCC TAGCCCTCCC CCCAGCTCCC TGCACCGCCG CAGAAGCAGC CCCTCGAGGC 2220 CTACAGAGGA GGCCTCAAAG CAACCCGCTG GAGCCCACAG CGAGCCTGTG CCTTCCTCCC 2280 CGCCTCCTCC CACTGGGACT CCCAGCAGAG CCCACCAGCC AGCCCTGGCC CACCCCCCAG 2340 CCTCCAGAGA AGCCCCGCAC GGGCTGTCTG GGTGTCCGCC ATCCAGGGTC TGGCAGAGCC 2400

TCTGAGATGA TGCATGATGC CCTCCCCTCA GCGCAGGCTG CAGAGCCCGG CCCCACCTCC 2460 CTGCGCCCTT GAGGGGCCCC AGCGTCTGCA GGGTGACGCC TGAGACAGCA CCACTGCTGA 2520 GGAGTCTGAG GACTGTCCTC CCACAGACCC TGCAGTGAGG GGCCCTCCAT GCGCAGATGA 2580 GGGGCCACTG ACCCACCTGC GCTTCTGCTG GAGGAGGGGA AGCTGGGCCC AAAGGCCCAG 2640 GGAGGCAGCG TGGGCTCTGC CAATGTGGGC TGCCCCTCGC ACACAGGGCT CACAGGGCAG 2700 GCCTTGCTGG GGTCCAGGGC TGTTGGAGGA CCCCGAGGGC TGAGGAGCAG CCAGGACCCG 2760 CCTGCTCCCA TCCTCACCCA GATCAGGAAC CAGGGCCTCC CTGTTCACGG TGACACAGGT 2820 CAGGGCTCAG AGTGACCCTC GGCTGTCACC TGCTCACAGG GATGCTGGTG GCTGGTGAGA 2880 CCCCGCACTG CACACGGGAA TGCCTAGGTC CCTTCCCGAC CCAGCCAGCT GCACTGCAGG 2940 GCACGGGGAC CTGGATAGTT AAGGGCTTTT CCAAACATGC ATCCATTTAC TGACACTTCC 3000 TGTCCTTGTT CATGGAGAGC TGTTCGCTCC TCCCAGATGG CTTCGGAGGC CCGCAGGGCC 3060 CACCTTGGAC CCTGGTGACC TCCTGTCACT CACTGAGGCC ATCAGGGCCC TGCCCCAGGC 3120 CTGGACGGGC CCTCCTTCCC TCCTGTGCCC CAGCTGCCAG GTGGCCCTGG GGAGGGGTGG 3180 TGTGGTGTTG GGAAGGGGTC CTGCAGGGGG AGGAGGACTT GGAGGGTCTG GGGGCAGCTG 3240 TCCTGAACCG ACTGACCCTG AGGAGGCCGC TTAGTGCTGC TTTGCTTTTC ATCACCGTCC 3300 CGCACAGTGG ACGGAGGTCC CCGGTTGCTG GTCAGGTCCC CATGGCTTGT TCTCTGGAAC 3360 CTGACTTTAG ATGTTTTGGG ATCAGGAGCC CCCAACACAG GCAAGTCCAC CCCATAATAA 3420 CCCTGCCAGT GCCAGGGTGG GCTGGGGACT CTGGCACAGT GATGCCGGGC GCCAGGACAG 3480 CAGCACTCCC GCTGCACACA GACGGCCTAG GGGTGGCGCT CAGACCCCAC CCTACGCTCA 3540 TCTCTGGAAG GGGCAGCCCT GAGTGGTCAC TGGTCAGGGC AGTGGCCAAG CCTGCTGTGT 3600 CCTTCCTCCA CAAGGTCCCC CCACCGCTCA GTGTCAGCGG GTGACGTGTG TTCTTTTGAG 3660 TCCTTGTATG AATAAAAGGC TGGAAACCTA AA Protein sequence 17 Gene name : glypican 1 Unigene number : Hs. 2699 Protein Accession # : NP 002072 Signal sequence : none found Pfam domain : Glypican protein [2-490] Transmembrane domains : none found Cellular Localization : plasma membrane 1 11 21 31 41 51 MELRARGWWL LCAAAALVAC ARGDPASKSR SCGEVRQIYG AKGFSLSDVP QAEISGEHLR 60 ICPQGYTCCT SEMEENLANR SHAELETALR DSSRVLQAML ATQLRSFDDH FQHLLNDSER 120 TLQATFPGAF GELYTQNARA FRDLYSELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP 180 QLLLPDDYLD CLGKQAEALR PFGEAPRELR LRATRAFVAA RSFVQGLGVA SDWRKVAQV 240 PLGPECSRAV MKLVYCAHCL GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI 300 TDKFWGTSGV ESVIGSVHTW LAEAINALQD NRDTLTAKVI QGCGNPKVNP QGPGPEEKRR 360 RGKLAPRERP PSGTLEKLVS EAKAQLRDVQ DFWISLPGTL CSEKMALSTA SDDRCWNGMA 420 RGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRSA YNGNDVDFQD 480 ASDDGSGSGS DNA sequence 18 Gene name : NY-REN-24 antigen Unigene number : Hs. 128425 Nucleic Acid Accession # : AF155102 Coding sequence : 27-908 1 11 21 31 41 51 GCGAGGGCGA GGGCGAGGCG GTGCTCATGG AGGAGGACCT GATCCAGCAG AGCCTGGACG 60 ACTACGACGC CGGCAGGTAC AGCCCGCGGC TGCTCACGGC GCACGAGCTG CCACTGGACG 120 CGCACGTGCT GGAACCGGAT GAGGACCTGC AGCGCCTGCA GCTCTCGCGC CAGCAGCTCC 180 AGGTCACGGG AGACGCCAGC GAGAGCGCCG AGGACATCTT CTTCCGGCGG GCCAAGGAGG 240 GCATGGGCCA GGACGAGGCG CAGTTCAGCG TGGAGATGCC ACTCACCGGC AAGGCCTACC 300 TGTGGGCCGA CAAGTACCGG CCACGCAAGC CGCGCTTCTT CAACCGCGTG CACACGGGCT 360 TCGAGTGGAA CAAGTACAAC CAGACGCACT ACGACTTTGA CAACCCACCG CCCAAGATCG 420 TGCAGGGATA CAAGTTCAAC ATCTTCTACC CCGACCTCAT CGACAAGCGC TCCACGCCCG 480 AGTACTTCCT GGAGGCCTGC GCCGACAACA AGGATTTCGC CATCCTGCGC TTCACGCGGG 540 GCCGCCTACG AGGACATCGC TTTCAAGATC GTCAACCGCG AGTGGGAATA CTCGCACCGC 600 CACGGCTTCC GCTGCCAGTT TGCCAACGGC ATCTTCCAGC TGTGCTTTCA CTTCAAGCGC 660 TACCGCTATC GGCGGTGACG GCCCTGGGGA ACGGCAGGCC AGGAGGGCCG AGGGCCACAC 720 GGGTGCCACA GCCCAGGTCG GAGTGGCCCA GCCGGCAGGC TTGTTCTTCA GCATCCGACG 780 GGAACATCTC CAACAGAAGC AAAACGGAAA GTGCCTCCCG GACCCCCAGA GGGCCACCCA 840 ACCTCACCAG TCACCAGCCC CAGACCACCC ACAGCCCCTC CCAGACACCC CGCCTCATCT 900 GGAAATAGTT CCGTTTGTTT CTCTAAAAAG ACTTGTAGGT GGGAAAAAAA ATCTTTTGTT 960 CTCATGGAAT TGGCCTATTG GCAAGATCGC ATGTTTTTTT AATAAACGTT GTATTTTAGA 1020 ATAAAA Protein sequence 18 Gene name : NY-REN-24 antigen Unigene number : Hs. 128425 Protein Accession # : AAD42868 Signal sequence : none found Transmembrane domains : none found Cellular Localization : plasma membrane 1 11 21 31 41 51 GEGEAVLME EDLIQQSLDD YDAGRYSPRL LTAHELPLDA HVLEPDEDLQ RLQLSRQQLQ 60 TGDASESAE DIFFRRAKEG MGQDEAQFSV EMPLTGKAYL WADKYRPRKP RFFNRVHTGF 120 WNKYNQTHY DFDNPPPKIV QGYKFNIFYP DLIDKRSTPE YFLEACADNK DFAILRFTRG 180 LRGHRFQDR QPRVGILAPP RLPLPVCQRH LPAVLSLQAL PLSAVTALGN GRPGGPRATR 240 PQPRSEWPS RQACSSASDG NISNRSKTES ASRTPRGPPN LTSHQPQTTH SPSQTPRLIW 300

DNA sequence 19 Gene name : tumor necrosis factor receptor superfamily, member 1A Unigene number : Hs. 159 Probeset Accession # : BE295782 Nucleic Acid Accession # : NM001065 Coding sequence : 256-1623 1 11 21 31 41 51 ( CGGCCCAGTG ATCTTGAACC CCAAAGGCCA GAACTGGAGC CTCAGTCCAG AGAATTCTGA 60 GAAAATTAAA GCAGAGAGGA GGGGAGAGAT CACTGGGACC AGGCCGTGAT CTCTATGCCC 120 GAGTCTCAAC CCTCAACTGT CACCCCAAGG CACTTGGGAC GTCCTGGACA GACCGAGTCC 180 CGGGAAGCCC CAGCACTGCC GCTGCCACAC TGCCCTGAGC CCAAATGGGG GAGTGAGAGG 240 CCATAGCTGT CTGGCATGGG CCTCTCCACC GTGCCTGACC TGCTGCTGCC GCTGGTGCTC 300 CTGGAGCTGT TGGTGGGAAT ATACCCCTCA GGGGTTATTG GACTGGTCCC TCACCTAGGG 360 GACAGGGAGA AGAGAGATAG TGTGTGTCCC CAAGGAAAAT ATATCCACCC TCAAAATAAT 420 TCGATTTGCT GTACCAAGTG CCACAAAGGA ACCTACTTGT ACAATGACTG TCCAGGCCCG 480 GGGCAGGATA CGGACTGCAG GGAGTGTGAG AGCGGCTCCT TCACCGCTTC AGAAAACCAC 540 CTCAGACACT GCCTCAGCTG CTCCAAATGC CGAAAGGAAA TGGGTCAGGT GGAGATCTCT 600 TCTTGCACAG TGGACCGGGA CACCGTGTGT GGCTGCAGGA AGAACCAGTA CCGGCATTAT 660 TGGAGTGAAA ACCTTTTCCA GTGCTTCAAT TGCAGCCTCT GCCTCAATGG GACCGTGCAC 720 CTCTCCTGCC AGGAGAAACA GAACACCGTG TGCACCTGCC ATGCAGGTTT CTTTCTAAGA 780 GAAAACGAGT GTGTCTCCTG TAGTAACTGT AAGAAAAGCC TGGAGTGCAC GAAGTTGTGC 840 CTACCCCAGA TTGAGAATGT TAAGGGCACT GAGGACTCAG GCACCACAGT GCTGTTGCCC 900 CTGGTCATTT TCTTTGGTCT TTGCCTTTTA TCCCTCCTCT TCATTGGTTT AATGTATCGC 960 TACCAACGGT GGAAGTCCAA GCTCTACTCC ATTGTTTGTG GGAAATCGAC ACCTGAAAAA 1020 GAGGGGGAGC TTGAAGGAAC TACTACTAAG CCCCTGGCCC CAAACCCAAG CTTCAGTCCC 1080 ACTCCAGGCT TCACCCCCAC CCTGGGCTTC AGTCCCGTGC CCAGTTCCAC CTTCACCTCC 1140 AGCTCCACCT ATACCCCCGG TGACTGTCCC AACTTTGCGG CTCCCCGCAG AGAGGTGGCA 1200 CCACCCTATC AGGGGGCTGA CCCCATCCTT GCGACAGCCC TCGCCTCCGA CCCCATCCCC 1260 AACCCCCTTC AGAAGTGGGA GGACAGCGCC CACAAGCCAC AGAGCCTAGA CACTGATGAC 1320 CCCGCGACGC TGTACGCCGT GGTGGAGAAC GTGCCCCCGT TGCGCTGGAA GGAATTCGTG 1380 CGGCGCCTAG GGCTGAGCGA CCACGAGATC GATCGGCTGG AGCTGCAGAA CGGGCGCTGC 1440 CTGCGCGAGG CGCAATACAG CATGCTGGCG ACCTGGAGGC GGCGCACGCC GCGGCGCGAG 1500 GCCACGCTGG AGCTGCTGGG ACGCGTGCTC CGCGACATGG ACCTGCTGGG CTGCCTGGAG 1560 GACATCGAGG AGGCGCTTTG CGGCCCCGCC GCCCTCCCGC CCGCGCCCAG TCTTCTCAGA 1620 TGAGGCTGCG CCCCTGCGGG CAGCTCTAAG GACCGTCCTG CGAGATCGCC TTCCAACCCC 1680 ACTTTTTTCT GGAAAGGAGG GGTCCTGCAG GGGCAAGCAG GAGCTAGCAG CCGCCTACTT 1740 GGTGCTAACC CCTCGATGTA CATAGCTTTT CTCAGCTGCC TGCGCGCCGC CGACAGTCAG 1800 CGCTGTGCGC GCGGAGAGAG GTGCGCCGTG GGCTCAAGAG CCTGAGTGGG TGGTTTGCGA 1860 GGATGAGGGA CGCTATGCCT CATGCCCGTT TTGGGTGTCC TCACCAGCAA GGCTGCTCGG 1920 GGGCCCCTGG TTCGTCCCTG AGCCTTTTTC ACAGTGCATA AGCAGTTTTT TTTGTTTTTG 1980 TTTTGTTTTG TTTTGTTTTT AAATCAATCA TGTTACACTA ATAGAAACTT GGCACTCCTG 2040 TGCCCTCTGC CTGGACAAGC ACATAGCAAG CTGAACTGTC CTAAGGCAGG GGCGAGCACG 2100 GAACAATGGG GCCTTCAGCT GGAGCTGTGG ACTTTTGTAC ATACACTAAA ATTCTGAAGT 2160 T Protein sequence 19 Gene name : tumor necrosis factor receptor superfamily, member 1A Unigene number : Hs. 159 Protein Accession # : NP 001056 Signal sequence : 1-29 TNFR domain : 44-81, 84-125, 127-166, 168-195 Transmembrane domains : 211-234 Cellular Localization : plasma membrane 11 21 31 41 51 t t)) t i MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI RPQNNSICCT 60 KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD 120 RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KCNTVCTCHA GFFLRENECV 180 SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK 240 SKLYSIVCGK STPEKEGELE GTTTKPLAPN PSPSPTPGFT PTLGFSPVPS STFTSSSTYT 300 PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK WEDSAHKPQS LDTDDPATLY 360 AWENVPPLR WKEFVRRLGL SDHEIDRLEL QNGRCLREAQ YSMLATWRRR TPRREATLEL 420 LGRVLRDMDL LGCLEDIEEA LCGPAALPPA PSLLR DNA sequence 20 Gene name : prominin (mouse)-like 1 Unigene number : Rs. 112360 Probeset Accession # : R40057 Nucleic Acid Accession # : NM 006017 Coding sequence : 38-2635 1 11 21 31 41 51 CCAAGTTCTA CCTCATGTTT GGAGGATCTT GCTAGCTATG GCCCTCGTAC TCGGCTCCCT 60 GTTGCTGCTG GGGCTGTGCG GGAACTCCTT TTCAGGAGGG CAGCCTTCAT CCACAGATGC 120 TCCTAAGGCT TGGAATTATG AATTGCCTGC AACAAATTAT GAGACCCAAG ACTCCCATAA 180 AGCTGGACCC ATTGGCATTC TCTTTGAACT AGTGCATATC TTTCTCTATG TGGTACAGCC 240 GCGTGATTTC CCAGAAGATA CTTTGAGAAA ATTCTTACAG AAGGCATATG AATCCAAAAT 300 TGATTATGAC AAGCCAGAAA CTGTAATCTT AGGTCTAAAG ATTGTCTACT ATGAAGCAGG 360 GATTATTCTA TGCTGTGTCC TGGGGCTGCT GTTTATTATT CTGATGCCTC TGGTGGGGTA 420 TTTCTTTTGT ATGTGTCGTT GCTGTAACAA ATGTGGTGGA GAAATGCACC AGCGACAGAA 480 GGAAAATGGG CCCTTCCTGA GGAAATGCTT TGCAATCTCC CTGTTGGTGA TTTGTATAAT 540 AATAAGCATT GGCATCTTCT ATGGTTTTGT GGCAAATCAC CAGGTAAGAA CCCGGATCAA 600 AAGGAGTCGG AAACTGGCAG ATAGCAATTT CAAGGACTTG CGAACTCTCT TGAATGAAAC 660

TCCAGAGCAA ATCAAATATA TATTGGCCCA GTACAACACT ACCAAGGACA AGGCGTTCAC 720 AGATCTGAAC AGTATCAATT CAGTGCTAGG AGGCGGAATT CTTGACCGAC TGAGACCCAA 780 CATCATCCCT GTTCTTGATG AGATTAAGTC CATGGCAACA GCGATCAAGG AGACCAAAGA 840 GGCGTTGGAG AACATGAACA GCACCTTGAA GAGCTTGCAC CAACAAAGTA CACAGCTTAG 900 CAGCAGTCTG ACCAGCGTGA AAACTAGCCT GCGGTCATCT CTCAATGACC CTCTGTGCTT 960 GGTGCATCCA TCAAGTGAAA CCTGCAACAG CATCAGATTG TCTCTAAGCC AGCTGAATAG 1020 CAACCCTGAA CTGAGGCAGC TTCCACCCGT GGATGCAGAA CTTGACAACG TTAATAACGT 1080 TCTTAGGACA GATTTGGATG GCCTGGTCCA ACAGGGCTAT CAATCCCTTA ATGATATACC 1140 TGACAGAGTA CAACGCCAAA CCACGACTGT CGTAGCAGGT ATCAAAAGGG TCTTGAATTC 1200 CATTGGTTCA GATATCGACA ATGTAACTCA GCGTCTTCCT ATTCAGGATA TACTCTCAGC 1260 ATTCTCTGTT TATGTTAATA ACACTGAAAG TTACATCCAC AGAAATTTAC CTACATTGGA 1320 AGAGTATGAT TCATACTGGT GGCTGGGTGG CCTGGTCATC TGCTCTCTGC TGACCCTCAT 1380 CGTGATTTTT TACTACCTGG GCTTACTGTG TGGCGTGTGC GGCTATGACA GGCATGCCAC 1440 CCCGACCACC CGAGGCTGTG TCTCCAACAC CGGAGGCGTC TTCCTCATGG TTGGAGTTGG 1500 ATTAAGTTTC CTCTTTTGCT GGATATTGAT GATCATTGTG GTTCTTACCT TTGTCTTTGG 1560 TGCAAATGTG GAAAAACTGA TCTGTGAACC TTACACGAGC AAGGAATTAT TCCGGGTTTT 1620 GGATACACCC TACTTACTAA ATGAAGACTG GGAATACTAT CTCTCTGGGA AGCTATTTAA 1680 TAAATCAAAA ATGAAGCTCA CTTTTGAACA AGTTTACAGT GACTGCAAAA AAAATAGAGG 1740 CACTTACGGC ACTCTTCACC TGCAGAACAG CTTCAATATC AGTGAACATC TCAACATTAA 1800 TGAGCATACT GGAAGCATAA GCAGTGAATT GGAAAGTCTG AAGGTAAATC TTAATATCTT 1860 TCTGTTGGGT GCAGCAGGAA GAAAAAACCT TCAGGATTTT GCTGCTTGTG GAATAGACAG 1920 AATGAATTAT GACAGCTACT TGGCTCAGAC TGGTAAATCC CCCGCAGGAG TGAATCTTTT 1980 ATCATTTGCA TATGATCTAG AAGCAAAAGC AAACAGTTTG CCCCCAGGAA ATTTGAGGAA 2040 CTCCCTGAAA AGAGATGCAC AAACTATTAA AACAATTCAC CAGCAACGAG TCCTTCCTAT 2100 AGAACAATCA CTGAGCACTC TATACCAAAG CGTCAAGATA CTTCAACGCA CAGGGAATGG 2160 ATTGTTGGAG AGAGTAACTA GGATTCTAGC TTCTCTGGAT TTTGCTCAGA ACTTCATCAC 2220 AAACAATACT TCCTCTGTTA TTATTGAGGA AACTAAGAAG TATGGGAGAA CAATAATAGG 2280 ATATTTTGAA CATTATCTGC AGTGGATCGA GTTCTCTATC AGTGAGAAAG TGGCATCGTG 2340 CAAACCTGTG GCCACCGCTC TAGATACTGC TGTTGATGTC TTTCTGTGTA GCTACATTAT 2400 CGACCCCTTG AATTTGTTTT GGTTTGGCAT AGGAAAAGCT ACTGTATTTT TACTTCCGGC 2460 TCTAATTTTT GCGGTAAAAC TGGCTAAGTA CTATCGTCGA ATGGATTCGG AGGACGTGTA 2520 CGATGATGTT GAAACTATAC CCATGAAAAA TATGGAAAAT GGTAATAATG GTTATCATAA 2580 AGATCATGTA TATGGTATTC ACAATCCTGT TATGACAAGC CCATCACAAC ATTGATAGCT 2640 GATGTTGAAA CTGCTTGAGC ATCAGGATAC TCAAAGTGGA AAGGATCACA GATTTTTGGT 2700 AGTTTCTGGG TCTACAAGGA CTTTCCAAAT CCAGGAGCAA CGCCAGTGGC AACGTAGTGA 2760 CTCAGGCGGG CACCAAGGCA ACGGCACCAT TGGTCTCTGG GTAGTGCTTT AAGAATGAAC 2820 ACAATCACGT TATAGTCCAT GGTCCATCAC TATTCAAGGA TGACTCCCTC CCTTCCTGTC 2880 TATTTTTGTT TTTTACTTTT TTACACTGAG TTTCTATTTA GACACTACAA CATATGGGGT 2940 GTTTGTTCCC ATTGGATGCA TTTCTATCAA AACTCTATCA AATGTGATGG CTAGATTCTA 3000 ACATATTGCC ATGTGTGGAG TGTGCTGAAC ACACACCAGT TTACAGGAAA GATGCATTTT 3060 GTGTACAGTA AACGGTGTAT ATACCTTTTG TTACCACAGA GTTTTTTAAA CAAATGAGTA 3120 TTATAGGACT TTCTTCTAAA TGAGCTAAAT AAGTCACCAT TGACTTCTTG GTGCTGTTGA 3180 AAATAATCCA TTTTCACTAA AAGTGTGTGA AACCTACAGC ATATTCTTCA CGCAGAGATT 3240 TTCATCTATT ATACTTTATC AAAGATTGGC CATGTTCCAC TTGGAAATGG CATGCAAAAG 3300 CCATCATAGA GAAACCTGCG TAACTCCATC TGACAAATTC AAAAGAGAGA GAGAGATCTT 3360 GAGAGAGAAA TGCTGTTCGT TCAAAAGTGG AGTTGTTTTA ACAGATGCCA ATTACGGTGT 3420 ACAGTTTAAC AGAGTTTTCT GTTGCATTAG GATAAACATT AATTGGAGTG CAGCTAACAT 3480 GAGTATCATC AGACTAGTAT CAAGTGTTCT AAAATGAAAT ATGAGAAGAT CCTGTCACAA 3540 TTCTTAGATC TGGTGTCCAG CATGGATGAA ACCTTTGAGT TTGGTCCCTA AATTTGCATG 3600 AAAGCACAAG GTAAATATTC ATTTGCTTCA GGAGTTTCAT GTTGGATCTG TCATTATCAA 3660 AAGTGATCAG CAATGAAGAA CTGGTCGGAC AAAATTTAAC GTTGATGTAA TGGAATTCCA 3720 GATGTAGGCA TTCCCCCCAG GTCTTTTCAT GTGCAGATTG CAGTTCTGAT TCATTTGAAT 3780 AAAAAGGAAC TTGGC Protein sequence 20 Gene name : prominin (mouse)-like 1 Unigene number : Hs. 112360 Protein Accession # : NP 006008 Signal sequence : 1-21 Transmembrane domains : 105-127, 157-179, 438-460, 482-504, 784-806 Cellular Localization : plasma membrane 1 11 21 31 41 51 MALVLGSLLL LGLCGNSFSG GQPSSTDAPK AWNYELPATN YETQDSHKAG PIGILFELVH 60 IFLYVVQPRD FPEDTLRKFL QKAYESKIDY DKPETVILGL KIVYYEAGII LCCVLGLLFI 120 ILMPLVGYFF CMCRCCNKCG GEMHQRQKEN GPFLRKCFAI SLLVICIIIS IGIFYGFVAN 180 HQVRTRIKRS RKLADSNFKD LRTLLNETPE QIKYILAQYN TTKDKAFTDL NSINSVLGGG 240 ILDRLRPNII PVLDEIKSMA TAIKETKEAL ENMNSTLKSL HQQSTQLSSS LTSVKTSLRS 300 SLNDPLCLVH PSSETCNSIR LSLSQLNSNP ELRQLPPVDA ELDNVNNVLR TDLDGLVQQG 360 YQSLNDIPDR VQRQTTTWA GIKRVLNSIG SDIDNVTQRL PIQDILSAFS VYVNNTESYI 420 HRNLPTLEEY DSYWWLGGLV ICSLLTLIVI FYYLGLLCGV CGYDRHATPT TRGCVSNTGG 480 VFLMVGVGLS FLFCWILMII WLTFVFGAN VEKLICEPYT SKELFRVLDT PYLLNEDWEY 540 YLSGKLFNKS KMKLTFEQVY SDCKKNRGTY GTLHLQNSFN ISEHLNINEH TGSISSELES 600 LKVNLNIFLL GAAGRKNLQD FAACGIDRMN YDSYLAQTGK SPAGVNLLSF AYDLEAKANS 660 LPPGNLRNSL KRDAQTIKTI HQQRVLPIEQ SLSTLYQSVK ILQRTGNGLL ERVTRILASL 720 DFAQNFITNN TSSVIIEETK KYGRTIIGYF EHYLQWIEFS ISEKVASCKP VATALDTAVD 780 VFLCSYIIDP LNLFWFGIGK ATVFLLPALI FAVKLAKYYR RMDSEDVYDD VETIPMKNME 840 NGNNGYHKDH VYGIHNPVMT SPSQH DNA sequence 21 Gene name : G protein-coupled receptor 39 Unigene number : Hs. 85339 Nucleic Acid Accession # : NM 001508 Coding sequence : 1-1362

1 11 21 31 41 51 I i I I I ! ATGGCTTCAC CCAGCCTCCC GGGCAGTGAC TGCTCCCAAA, TCATTGATCA CAGTCATGTC 60 CCCGAGTTTG AGGTGGCCAC CTGGATCAAA ATCACCCTTA TTCTGGTGTA CCTGATCATC 120 TTCGTGATGG GCCTTCTGGG GAACAGCGCC ACCATTCGGG TCACCCAGGT GCTGCAGAAG 180 AAAGGATACT TGCAGAAGGA GGTGACAGAC CACATGGTGA GTTTGGCTTG CTCGGACATC 240 TTGGTGTTCC TCATCGGCAT GCCCATGGAG TTCTACAGCA TCATCTGGAA TCCCCTGACC 300 ACGTCCAGCT ACACCCTGTC CTGCAAGCTG CACACTTTCC TCTTCGAGGC CTGCAGCTAC 360 GCTACGCTGC TGCACGTGCT GACACTCAGC TTTGAGCGCT ACATCGCCAT CTGTCACCCC 420 TTCAGGTACA AGGCTGTGTC GGGACCTTGC CAGGTGAAGC TGCTGATTGG CTTCGTCTGG 480 GTCACCTCCG CCCTGGTGGC ACTGCCCTTG CTGTTTGCCA TGGGTACTGA GTACCCCCTG 540 GTGAACGTGC CCAGCCACCG GGGTCTCACT TGCAACCGCT CCAGCACCCG CCACCACGAG 600 CAGCCCGAGA CCTCCAATAT GTCCATCTGT ACCAACCTCT CCAGCCGCTG GACCGTGTTC 660 CAGTCCAGCA TCTTCGGCGC CTTCGTGGTC TACCTCGTGG TCCTGCTCTC CGTAGCCTTC 720 ATGTGCTGGA ACATGATGCA GGTGCTCATG AAAAGCCAGA AGGGCTCGCT GGCCGGGGGC 780 ACGCGGCCTC CGCAGCTGAG GAAGTCCGAG AGCGAAGAGA GCAGGACCGC CAGGAGGCAG 840 ACCATCATCT TCCTGAGGCT GATTGTTGTG ACATTGGCCG TATGCTGGAT GCCCAACCAG 900 ATTCGGAGGA TCATGGCTGC GGCCAAACCC AAGCACGACT GGACGAGGTC CTACTTCCGG 960 GCGTACATGA TCCTCCTCCC CTTCTCGGAG ACGTTTTTCT ACCTCAGCTC GGTCATCAAC 1020 CCGCTCCTGT ACACGGTGTC CTCGCAGCAG TTTCGGCGGG TGTTCGTGCA GGTGCTGTGC 1080 TGCCGCCTGT CGCTGCAGCA CGCCAACCAC GAGAAGCGCC TGCGCGTACA TGCGCACTCC 1140 ACCACCGACA GCGCCCGCTT TGTGCAGCGC CCGTTGCTCT TCGCGTCCCG GCGCCAGTCC 1200 TCTGCAAGGA GAACTGAGAA GATTTTCTTA AGCACTTTTC AGAGCGAGGC CGAGCCCCAG 1260 TCTAAGTCCC AGTCATTGAG TCTCGAGTCA CTAGAGCCCA ACTCAGGCGC GAAACCAGCC 1320 AATTCTGCTG CAGAGAATGG TTTTCAGGAG CATGAAGTTT GA Protein sequence 21 Gene name : G protein-coupled receptor 39 Unigene number : Hs. 85339 Protein Accession # : NM 001508, NP 001409 Signal sequence : none found Pfam domains : 7tm 1 [72-172, 224-344] Transmembrane domains : 32-54, 68-90, 111-133, 151-173, 221-243, 280-301, 320-342 Cellular Localization : plasma membrane 1 11 21 31 41 51 MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSA TIRVTQVLQK 60 KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT TSSYTLSCKL HTFLFEACSY 120 ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFVW VTSALVALPL LFAMGTEYPL 180 VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSRWTVF QSSIFGAF YLWLLSVAF 240 MCWNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIW TLAVCWMPNQ 300 IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC 360 CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLPASRRQS SARRTEKIFL STFQSEAEPQ 420 SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV TABLERA : ABOUT 1260 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES Table 8A lists about 1260 genes up-regulated in glioblastoma compared to normal adult Ussues. These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of"average"glioblastoma to"average"normal adult tissues was greater than or equal to 2. 5. The Maverage glieblastoma levei was set to the 75th percentile amongst various glioblastoma tumors. The"average"normal adult tissue level was set to the 85th percent !) e amongst various non-malignant tissues, In order to remove gene- specific background levels of non-specific hybridization, the 10th percentile value amongst the non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of 75th percentile tumor to 85th percentile normal body tissue Pkey ExAccn UnigenelD Unigene Title R1 431917 D16181 Hs. 2868 peripheral myetin protein 2 75. 2 427343 At880044 Hs. 176977 protein kinase C binding protein 2 74. 6 455601 A1368680 Hs. 816 5RY (sex determining regions-box 2 74. 2 428321 Api699994 Hs. 2868 peripheral myelin protein 2 71. 6 412719 AW016610 Hs. 129911 ESTs 70. 7 449494 AW237014 Hs. 315369 Homo sapiens cDNA : FLJ23075 fis, clone L 66. 3 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 64. 3 413472 BE242870 Hs. 75379 solute carrier family 1 (glial high affi 60. 1 456759 BE259150 Hs. 127792 delta (Drosophila)-like 3 52. 3 435147 AL133731 Hs. 4774 Homo sapiens mRNA ; cDNA DKFZp761 C1712 (f 46. 7 425842 A1587490 Hs. 159623 NK-2 (Drosophila) homolog B 40. 1 412733 AA984472 Hs. 74554 Km0080 protein 39. 0 418375 NM_003081 Hs. 84389 synaptosomal-associated protein, 25kD 38. 7 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 37. 2 423849 AL157425 Hs. 133315 Homo sapiens mRNA ; cDNA DKFZp761J1324 (f 36. 8 413333 M74028 Hs. 75297 fibroblast growth factor 1 (acidic) 32. 8 416829 AB013805 Hs. 80220 catenin (cadherin-associated protein), d 31. 8 431941 AK000106 Hs. 272227 Homo sapiens cDNA FLJ20099 fis, clone CO 31. 8 436878 BE465204 Hs. 47448 ESTs 31. 4 426325 D28114 Hs. 169309 myelin-associated oligodendrocyte basic 30. 9 425057 AA826434 Hs. 1619 achaete-scute comptex (Drosophila) homol 30. 4 446711 AF169692 Hs. 12450 protocadherin9 30. 2 439415 F05538 Hs. 12825 ESTs 28. 3 430838 N46664 Hs. 169395 hypotheücal protein FLJ12015 26. 9

429466 M85835 Hs. 12827 ESTs 25. 9 447004 AW296968 Hs. 157539 ESTs 25. 3 424581 M62062 Hs. 150917 catenin (cadherin-associated protein), a 24. 8 452744 A1267652 Hs. 30504 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 24. 8 441285 NM 002374 Hs. 167 microtubuie-associated protein 2 24. 3 453642 A1370936 Hs. 34074 dipeptidylpeptidase Vi 24. 3 424140 Z48051 Hs. 141308 myelin oligodendrocyte glycoprotein 24. 2 450133 AW969769 Hs. 105201 ESTs 24. 2 408562 AI436323 Hs. 31141 Homo sapiens mRNA for KIAA1568 protein, 23. 3 448672 A) 955511 Hs. 225106 ESTs 22. 7 435708 A1362949 Hs. 75169 ESTs 22. 0 407034 U84540 gb : Human dystrobrevin isoform DTN-3 (DTN 21. 9 407168 R45175 Hs. 117183 ESTs 21. 7 431019 NM005249 Hs. 2714 forkhead box G1B 21. 5 409049 A1423132 Hs. 146343 ESTs 21. 4 433896 AW294729 Hs. 274461 ESTs 21. 1 445041 T64183 Hs. 282982 solute carder 21. 0 418738 AW388633 Hs. 6682 solute carrier family 7, (cationic amino 20. 4 444378 R41339 Hs. 12569 ESTs 20. 0 411305 BE241596 Hs. 69547 myelin basic protein 19. 9 437414 AW894071 Hs. 48448 hypothetical protein DKFZp547C176 19. 8 441016 AW138653 Hs. 25845 ESTs 19. 6 440435 AL042201 Hs. 21273 transcriptionfactorNYD-sp10 18. 5 438209 AL120659 Hs. 6111 aryl-hydrocarbonreceptornucleartransi 18. 4 452461 N78223 Hs. 108106 transcription factor 18. 1 409395 U46745 Hs. 54435 dystrobrevin, alpha 18. 1 417183 R52089 Hs. 172717 ESTs 18. 0 409638 AW450420 Hs. 21335 ESTs 18. 0 428392 H10233 Hs. 2265 secretorygranule, neuroendocrineprotei 18. 0 449611 A1970394 Hs. 197075 ESTs 17. 0 446692 Z44514 Hs. 156829 Homo sapiens mRNA for KIAA1763 protein, 16. 9 425088 AA663372 Hs. 169395 hypothetical protein FLJ12015 16. 9 444471 A8020684 Hs. 11217 KIAA0877 protein 16. 8 421659 NM_014459 Hs. 106511 protocadherin 17 16. 7 431725 X65724 Hs. 2839 Nonie disease (pseudoglioma) 16. 6 429276 AF056085 Hs. 198612 G protein-coupled receptor 51 16. 6 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 16. 5 441440 Ai801981 Hs. 30495 ESTs 15. 7 449433 Api672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 15. 7 421264 AL039123 Hs. 103042 microtubule-associated protein 1 B 15. 5 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 15. 3 413597 AW302885 Hs. 117183 ESTs 15. 1 424945 Api221919 Hs. 173438 hypothetical protein FLJ10582 14. 9 447414 D82343 Hs. 18551 neuroblastoma (nerve tissue) protein 14. 9 426269 H15302 Hs. 168950 Homo sapiens MARNA cDNADKFZp566A1046 (f 14. 8 416857 AA188775 Hs. 292453 ESTs 14. 7 419721 NM 001650 Hs. 288650 aquaporin 4 14. 6 411078 A1222020 Hs. 182364 CocoaCrisp 14. 4 453924 R49295 Hs. 24886 ESTs 14. 4 409389 AB007979 Hs. 301281 Homo sapiens mRNA, chromosome 1 specific 14. 3 430130 AL137311 Hs. 234074 Homo sapiens mRNA ; cDNADKFZp761G02121 (14. 1 410909 AW898161 Hs. 53112 ESTs, Moderately similar to ALU-HUMAN A 14. 0 412266 N59006 Hs. 26133 ESTs 14. 0 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) 14. 0 424790 AL119344 Hs. 13326 ESTs, Weakly similar to 2004399A chromos 14. 0 439239 A1031540 Hs. 235331 ESTs 14. 0 441497 R51064 Hs. 23172 ESTs 14. 0 445495 BE622641 Hs. 38489 ESTs, Weakly similar to 138022 hypothefi 14. 0 414245 BE148072 Hs. 75850 WASproteinfamily, memberl 13. 7 429900 AA460421 Hs. 30875 ESTs 13. 6 448595 AB014544 Hs. 21572 KIAA0644 gene product 13. 6 449605 AW138581 Hs. 198416 ESTs 13. 6 452526 W38537 Hs. 280740 hypotheucal protein MGC3040 13. 6 420547 AF1S5140 Hs. 98738 gonadotropin-revqulated testicular RNA he 13. 3 441350 AB020690 Hs. 7782 paraneoplasticantigen MA2 13. 3 420077 AW512260 Hs. 87767 ESTs 13. 2 424120 T80579 Hs. 290270 ESTs 13. 2 456965 AW13t 888 Hs. 172792 ESTs, Weakly similar to hypothetical pro 13. 2 423361 AW170055 Hs. 47628 ESTs 13. 1 428409 AW117207 Hs. 98523 ESTs 12. 9 417160 N76497 Hs. 1787 proteclipid protein I (Pelizaeus-Merzbac 12. 6 451621 A1879148 Hs. 26770 fatty acid binding protein 7, brain 12. 5 411379 Ai816344 Hs. 12554 ESTs, WeaklysimilartoNPL4_HUMANNUCLE 12. 5 436954 AA740151 Hs. 130425 ESTs 12. 4 430691 C14187 Hs. 103538 ESTs 12. 4 433551 A1985544 Hs. 12450 protocadherin9 12. 4 422544 AB018259 Hs. 118140 KiAA07169eneproduct 12. 2 427540 R12014 Hs. 20976 ESTs 12. 1 435624 AF218942 Hs. 24889 formin 2 12. 1 415849 R20529 Hs. 6806 ESTs 12. 1 428845 AL157579 Hs. 153610 KIAA0751 gene product 11. 9 442671 A1005668 Hs. 134779 EST 11. 9 444396 T65213 Hs. 4257 ESTs 11. 8

452752 AW044058 Hs. 33578 KIAA0820 protein 11. 8 425523 AB007948 Hs. 158244 KIAA0479 protein 11. 8 416072 AL110370 Hs. 79000 growth associated protein 43 11. 7 440184 AB002297 Hs. 7022 dedicator of cyto-kinesis 3 11. 7 428976 AL037824 Hs. 194695 ras homolog gene family, member 1 11. 6 444783 AK001468 Hs. 62180 aniflin (Drosophila Scraps homolog), act 11. 6 448299 AA497044 Hs. 20887 hypotheticai protein FLJ10392 11. 6 414214 D49958 Hs. 75819 glycoprotein M6A 11. 5 428982 NM_005097 Hs. 194704 leucine-rich, glioma inactivated 1 11. 5 405238 11. 4 420362 U79734 Hs. 97206 huntingtin interacting protein 1 11. 4 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (C/EBP), 11. 4 424918 R13982 Hs. 169309 myelin-associated oligodendrocyte basic 11. 4 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 11. 4 451952 AL120173 Hs. 301663 ESTs 11. 3 408829 NM_006042 Hs. 48384 heparan sulfate (glucosamine) 3-0-suWot 11. 3 424278 AK000723 Hs. 144517 hypothetical protein FLJ20716 11. 3 429418 A1381028 Hs. 118769 ESTs 11. 3 429918 AW873986 Hs. 119383 ESTs 11. 3 443912 R37257 Hs. 184780 ESTs 11. 3 448743 AB032962 Hs. 21896 KIAA1136 protein 11. 3 420092 AA814043 Hs. 88045 ESTs 11. 2 408081 AW451597 Hs. 167409 ESTs 11. 2 411642 NM 014932 Hs. 71132 neuroligin 1 10. 9 415170 R44386 Hs. 164578 ESTs 10. 9 426320 W47595 Hs. 169300 transforming growth factor, beta 2 10. 8 450568 AL050078 Hs. 25159 HomosapienscDNAFW10784fis, cloneNT 10. 8 425799 T08133 Hs. 182906 HomosapiensmRNAforKiM1872pnotein, 10. 8 423853 AB011537 Hs. 133466 slit (Drosophila) homolog 1 10. 7 400293 N51002 Hs. 306480 Homo sapiens mRNA ; cDNA DKFZp761 E2112 (f 10. 7 447773 A1423930 Hs. 36790 ESTs, Weakly similar to putative p150 (N 10. 7 448321 NM 005883 Hs. 20912 adenomatous polyposis coli like 10. 5 448533 AL119710 Hs. 21365 nucleosome assembly protein 1-like 3 10. 5 440684 A1253123 Hs. 127356 ESTs, Highly similar to S21424 nesting 10. 3 444017 U04840 Hs. 214 neuro-oncological ventral antigen 1 10. 3 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 10. 3 440471 AA886146 Hs. 307944 ESTs 10. 2 413063 AL035737 Hs. 75184 chitinase3-like1 (cartilageglycoprote 10. 1 439978 BE139460 Hs. 124673 Homo sapiens CDNA FLJ 11477 fis, clone HE 10. 1 448902 Z45998 Hs. 22543 Homo sapiens mRNA ; cDNA DKFZp76111912 (f 10. 1 424932 R14070 Hs. 315369 Homo sapiens cDNA : FLJ23075 fis, clone L 9. 9 431721 AB032996 Hs. 268044 KIAA1170 protein 9. 9 419088 Ai538323 Hs. 52620 integrin, beta 8 9. 8 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 9. 8 436511 AA721252 Hs. 291502 ESTs 9. 8 414696 AF002020 Hs. 76918 Niemann-Pick disease, type C1 9. 7 449539 W80363 Hs. 58446 ESTs 9. 7 412959 D87458 Hs. 75090 KIAA0282 protein 9. 6 412811 H06382 Hs. 21400 ESTs 9. 6 449300 A1656959 Hs. 222165 ESTs 9. 6 426344 H41821 Hs. 322469 transcriptional activator of the c-fos p 9. 5 419271 N34901 Hs. 238532 ESTs 9. 5 419078 M93119 Hs. 89584 insulinoma-associated 1 9. 4 451516 Ai800515 Hs. 12024 ESTs 9. 4 422656 Ai870435 Hs. 1569 LIM homeobox protein 2 9. 3 449318 AW236021 Hs. 78531 Homo sapiens, Similar to RIEN DNA 5730 9. 3 414175 A1308876 Hs. 103849 hypotheticalprotein OKFZp761D112 9. 3 415279 F04237 Hs. 1447 glial fibrillary acidic protein 9. 2 428784 Y12851 Hs. 193470 purinergic receptor P2X, ligand-gated io 9. 2 429903 AL134197 Hs. 93597 cyclin-dependent kinase 5, regulatory su 9. 2 424641 AB001106 Hs. 151413 giia maturation factor, beta 9. 1 417435 NM 005181 Hs. 82129 carbonic anhydrase III, muscle specific 9. 1 449448 D60730 Hs. 57471 ESTs 9. 1 408508 A1806109 Hs. 135736 KIAA1580 protein 9. 0 452785 AL359942 Hs. 296434 erythroid differentiation and denucleati 9. 0 448986 H42169 Hs. 18653 hypothetical protein FLJ14627 8. 9 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 8. 9 433800 A1034361 Hs. 135150 lung type-) cell membrane-associated gly 8. 9 408926 AF217525 Hs. 49002 Down syndrome cell adhesion molecule B. B 449625 NM 014253 Hs. 23796 odz (odd Oz/ten-m, Drosophila) homolog 1 8. 8 400292 AA250737 Hs. 72472 ESTs 8. 7 417404 NM 007350 Hs. 82101 pleckstrin homology-like domain, family 8. 7 420345 AW295230 Hs. 25231 ESTs 8. 7 429927 NM001115 Hs. 2522 adenylate cyclase 8 (brain) 8. 7 437528 N59646 Hs. 169745 crumbs (Drosophila) homolog 1 8. 7 440152 AB002376 Hs. 7006 KIAA0378 protein 8. 7 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 8. 6 400780 8. 6 434891 AA814309 Hs. 123583 ESTs 8. 6 449277 AA001064 Hs. 172976 ESTs 8. 6 415709 AA649850 Hs. 278558 ESTs 8. 5 439947 AB006627 Hs. 6788 astrotactin 8. 5 447197 R36075 gb : yh88bO1. s1 SoaresplacentaNb2HpHomo 8. 5

433042 AW193534 Hs. 281895 Homo sapiens cDNA FLJ11660 fis, clone HE 8. 4 416370 N90470 Hs. 203697 ESTs, Weakly similar to 138022 hypotheri 8. 4 452786 R61362 Hs. 106642 ESTs, Weakly similar to T09052 hypotheti 8. 4 415796 R87548 Hs. 78854 ATPase, Na+/K+transporting, beta2poly 8. 3 426271 AF026547 Hs. 169047 chondroitin sulfate proteoglycan 3 (neur 8. 3 408947 AL080093 Hs. 49117 Homo sapiens mRNA ; cDNA DKFZp564N1662 (f 8. 3 419863 AW952691 Hs. 93485 Homo sapiens mRNA ; cDNA DKFZp761 D191 (fr 8. 3 433447 U29195 Hs. 3281 neuronal pentraxin 11 8. 3 431467 N71831 Hs. 256398 Homo sapiens mRNA ; cDNA DKFZp434E0528 (f 8. 3 409327 L41162 Hs. 53563 collagen, type IX, alpha 3 8. 3 414300 A1304870 Hs. 188680 ESTs 8. 2 407728 AW071502 Hs. 175931 ESTs 8. 2 422798 R92347 Hs. 34574 ESTs, Weakly similar to ALU1 HUMAN ALU S 8. 2 419704 AA429104 Hs. 45057 ESTs 8. 2 429007 D80642 gb : HUM092E09B Human fetal brain (TFujiwa 8. 1 442710 A1015631 Hs. 23210 ESTs 8. 1 425048 H05468 Hs. 164502 ESTs 8. 1 429149 AW193360 Hs. 197962 ESTs, Weakly similar to 138022 hypotheti 8. 0 445740 T78281 Hs. 13226 Homosapiensdone25181 mRNAsequence 8. 0 418771 AA807881 Hs. 25329 ESTs 7. 9 422728 AW937826 Hs. 103262 ESTs, WeaklysimilartoZN91_HUMANZiNC 7. 9 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761 C07121 7. 9 448408 AA322866 Hs. 21107 neuroligin 7. 9 455364 H72176 Hs. 4273 hypothetical protein FLJ13159 7. 9 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponun, 7. 9 435501 AW051819 Hs. 129908, KIAA0591 protein 7. 8 423600 Ai633559 Hs. 310359 ESTs 7. 8 450625 AW970107 gb : EST382188 MAGE resequences, MAGK Homo 7. 8 415314 N88802 Hs. 5422 glycoprotein M6B 7. 7 420036 R60336 Hs. 52792 Homo sapiens mRNA ; cDNA DKFZp58611823 (f 7. 7 427687 AW003867 Hs. 1570 histamine receptor H1 7. 7 449328 Ai962493 Hs. 197647 ESTs 7. 7 419249 X14767 Hs. 89768 gamma-aminobutydc acid (GABA) A recepto 7. 7 407896 D76435 Hs. 41154 Zic family member 1 (odd-paired Drosophi 7. 7 419103 Z40229 Hs. 96423 hypothetical protein FU23033 7. 6 438779 NM_003787 Hs. 6414 nucleolar protein 4 7. 6 433532 AW975367 gb : EST387475 MAGE resequences, MAGN Homo 7. 6 448555 A1536697 Hs. 159863 ESTs 7. 5 439662 H97552 Hs. 269060 ESTs 7. 5 448543 AW897741 Hs. 21380 Homo sapiens mRNA ; cDNA DKFZp586P1124 (f 7. 5 410099 AA081630 Hs. 169387 KIAA0036 gene product 7. 5 431592 R69016 Hs. 213194 hypothetical protein MGC10895 7. 4 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 7. 4 405819 7. 4 407886 AW969688 Hs. 100826 ESTs 7. 4 437416 AL359605 Hs. 283851 Homo sapiens mRNA ; cDNA DKFZp547G036 (fr 7. 4 437698 R61837 Hs. 7990 ESTs, Moderately similar to 184505 calci 7. 4 408604 D51408 Hs. 21925 ESTs 7. 4 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 7. 3 447499 AW262580 Hs. 147674 protocadherin beta 16 7. 3 454036 AA374756 Hs. 93560 Homo sapiens mRNA for KIAA1771 protein, 7. 3 409746 NM004794 Hs. 56294 RAB33A, member RAS oncogene family 7. 2 410037 AB020725 Hs. 58009 KIAA0918 protein 7. 2 419318 AW969742 Hs. 291005 ESTs 7. 2 424051 AL110203 Hs. 138411 Homo sapiens mRNA ; cDNA DKFZp586J 1922 (f 7. 2 442026 A1243749 Hs. 8074 brain-specific angiogenesis inhibitor 3 7. 2 448243 AW369771 Hs. 52620 integrin, beta 8 7. 2 436281 AW411194 Hs. 85195 myeloid leukemia factor 1 7. 2 426429 X73114 Hs. 169849 myosin-binding protein C, slow-type 7. 2 407182 AA312551 Hs. 230157 ESTs 7. 1 415293 R49462 Hs. 106541 ESTs 7. 1 422764 A1767727 Hs. 47522 ESTs 7. 1 451592 A1805416 Hs. 213897 ESTs 7. 1 429469 M64590 Hs. 27 giycinedehydrogenase (decarboxy) ating ; 7. 0 415734 NM_014747 Hs. 78748 KIAA0237 gene product 7. 0 434149 Z43829 Hs. 19574 hypothetical protein MGC5469 7. 0 436726 AA324975 Hs. 128993 ESTs, Weakly similar to T00079 hypotheti 7. 0 417632 R20855 Hs. 5422 glycoprotein M6B 7. 0 422421 AA325138 Hs. 235873 hypothetical protein FLJ22672 6. 9 435267 N23797 Hs. 110114 ESTs 6. 9 437117 AL049256 Hs. 122593 ESTs 6. 9 445523 Z30118 Hs. 293788 ESTs, Moderately similar to unnamed prot 6. 9 445900 AF070526 Hs. 13429 Homo sapiens clone 24787 mRNA sequence 6. 9 445745 AB007924 Hs. 13245 KIAA0455 gene product 6. 9 424085 NM002914 Hs. 139226 replication factor C (activator 1) 2 (40 6. 9 428588 F12101 Hs. 185701 Homo sapiens mRNA full length insert cDN 6. 8 421723 AA620400 Hs. 300717 sodium channel, voltage-gated, type ill, 6. 8 447342 A1199268 Hs. 19322 Homosapiens. SimilartoRiKENcDNA2010 6. 7 443297 A1049864 Hs. 133029 ESTs 6. 7 443992 AW022228 Hs. 322922 ESTs 6. 7 453096 AW294631 Hs. 11325 ESTs 6. 7 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 6. 7 443761 A1525743 Hs. 160603 ESTs 6. 6

429609 AF002246 Hs. 210863 cell adhesion molecule with homology to 6. 6 435056 AW023337 Hs. 5422 glycoprotein M6B 6. 5 453431 AF094754 Hs. 32973 glycine receptor, beta 6. 5 444190 Api878918 Hs. 10526 cysteine and glycine-rich protein 2 6. 5 418110 R43523 Hs. 217754 hypothetcalprotein FU22202 6. 5 413988 M81883 Hs. 324784 glutamate decarboxylase 1 (brain, 67kD) 6. 5 420805 L10333 Hs. 99947. re6culon 1 6. 4 429125 AA446854 Hs. 271004 ESTs, Weakly similar to 138022 hypotheu 6. 4 435256 AF193766 Hs. 13872 cytokine-like protein C17 6. 4 407866 AW088232 Hs. 89506 paired box gene 6 (aniridia, keratitis) 6. 3 440700 AW952281 Hs. 296184 guanine nucleotide binding protein (G pr 6. 3 427701 AA411101 Hs. 243886 nuclear autoanfigenic sperm protein (his 6. 3 422949 AA319435 gb : EST21657 Adrenal gland tumor Homo sap 6. 2 445102 AW204610 Hs. 22270 ESTs 6. 2 452401 NM 007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 6. 2 435538 AB011540 Hs. 4930 low density lipoprotein receptor-related 6. 2 410102 AW248508 Hs. 279727 Homo sapiens DNA FLJ14035 fis, clone HE 6. 2 416871 H98716 gb : yx13d08. s1 Soares melanocyte 2NbHM Ho 6. 1 416702 AA186428 Hs. 85591 ESTs 6. 1 419347 C15944 Hs. 90005 superiorcervicalganglia, neuralspecifi 6. 1 424997 AL138167 Hs. 96920 ESTs 6. 1 438660 U95740 Hs. 6349 Homo sapiens, clone IMAGE : 3010666, mRNA, 6. 1 453649 Y07494 Hs. 34114 ATPase, Na+/K+ transporting, alpha 2 (+) 6. 1 449444 AW818436 Hs. 23590 solute camer family 16 (monocarboxylic 6. 1 414117 W88559 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 6. 0 425517 AF121179 gb : AF121179 Homo sapiens liver (Chang L-6. 0 427457 AW779105 Hs. 164682 ESTs 6. 0 437034 AA742643 gb : ny91c01. s1 NCI_CGAP_GCB1 Homo sapiens 6. 0 444170 AW613879 Hs. 102408 ESTs 6. 0 457183 H91882 Hs. 118569 Dvi-bindingproteinlDAX (inhibi60nof 6. 0 448999 AF179274 Hs. 22791 transmembrane protein with EGF4ike and 6. 0 454048 H05626 Hs. 6921 ESTs 6. 0 439772 AL365406 Hs. 10268 Homo sapiens mRNA full length insert cDN 5. 9 448944 AB014605 Hs. 22599 atrophin-1 interacting protein 1 ; activai 5. 9 410011 AB020641 Hs. 57856'PFTAIRE protein kinase 1 5. 9 415486 H12214 Hs. 13284 ESTs, Weakly similar to 2109260A B cell 5. 9 438993 AA828995 gb : od77bO8. s1 NCI_CGAP Homo sapiens 5. 9 447350 A1375572 Hs. 172634 ESTs 5. 9 451783 R42554 Hs. 210862 T-box, brain, 1 5. 9 447101 N72185 Hs. 44189 ESTs 5. 9 440492 R39127 Hs. 21433 hypothetical protein DKFZp547J036 5. 9 440274 R24595 Hs. 7122 scrapie responsive protein 1 5. 9 438461 AW075485 Hs. 286049 phosphosedne aminotransferase 5. 9 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 5. 8 437036 Ai571514 Hs. 133022 ESTs 5. 7 412225 AW902042 gb : QVO-NN1022-170400-193-cO2 NN1022 Homo 5. 7 426342 AF093419 Hs. 169378 multiple PDZ domain protein 5. 7 444218 AF070641 Hs. 10684 Homo sapiens clone 24421 mRNA sequence 5. 7 445828 F05802 Hs. 81907 ESTs 5. 7 447198 D61523 Hs. 283435 ESTs 5. 7 427897 NM017413 Hs. 303084 apelin ; pepüdeligandforAPJreceptor 5, 7 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 5. 7 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 5. 6 412155 R38167 Hs. 12449 Homo sapiens transmembrane protein HTMP1 5. 6 435718 R06569 Hs. 269534 ESTs 5. 6 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 5. 6 424481 R19453 Hs. 1787 proteolipid protein 1 (Peiizaeus-Merzbac 5. 6 451996 AW514021 Hs. 245510 ESTs 5. 6 422411 AW749443 Hs. 22511 ESTs 5. 6 438328 Al492261 Hs. 32450 ESTs 5. 6 433244 AB040943 Hs. 271285 KIAA1510 protein 5. 6 435191 R15912 Hs. 4817 Homo sapiens clone 24461 mRNA sequence 5. 5 418677 S83308 Hs. 87224 SRY (sex determining region Y)-box 5 5. 5 400859 5. 5 413625 AW451103 Hs. 71371 ESTs 5. 5 421863 Ai952677 Hs. 108972 Homo sapiens mRNA ; cDNA DKFZp434P228 (fr 5. 5 434933 R91095 Hs. 4276 KIAA1701 protein 5. 5 438702 A1879064 Hs. 54618 ESTs 5. 5 452055 A1377431 Hs. 141693 hypothetical protein MGC10858 5. 5 430979 A) 479755 Hs. 129010 ESTs 5. 5 412709 AL022327 Hs. 74518 KIAA0027 protein 5. 5 439920 H05430 Hs. 288433 neurotrimin 5. 5 424343 AW956360 Hs. 4748 adenylate cyclase activating polypeptide 5. 4 407846 AA426202 Hs. 40403 Cbp/p300-interac6ng transæ6vator, wit 5. 4 419235 AW470411 Hs. 288433 neurofimin 5. 4 418030 BE207573 Hs. 83321 neuromedin B 5. 4 410330 AW023630 Hs. 46786 ESTs 5. 4 410781 A1375672 Hs. 165028 ESTs 5. 4 420658 AW965215 Hs. 336656 ESTs 5. 4 421308 AA687322 Hs. 192843 leucine zipper protein FKSG14 5. 4 443740 R56434 Hs. 21062 ESTs 5. 4 426457 AW894667 Hs. 169965 chimerin (chimaerin) 1 5. 4 450375 AA009647 Hs. 8850 å disintegrin and metailoproteinase doma 5. 4

412494 AL133900 Hs. 792 ADP-ribosyla60nfactordomånprotein1 5. 4 426600 NM_003378 Hs. 171014 VGF nerve growth factor inducible 5. 4 424432 AB037821 Hs. 146858 protocadherin 10 5. 4 429250 H56585 Hs. 198308 tryptophan rich basic protein 5. 4 443785 AW449952 Hs. 190125 basic-helix-loop-helix-PAS protein 5. 4 436282 R91913 Hs. 272104 ESTs, ModeratelysimilartoALU1_HUMANA 5. 4 404584 5. 3 430091 AB032958 Hs. 233023 KIAA1132 protein 5. 3 439845 AL355743 Hs. 56663 Homo sapiens EST from clone 41214, full 5. 3 424001 W67883 Hs. 137476 paternally expressed 10 5. 3 425073 W39609 Hs. 22003 solute carrier family 6 (neurotransmitte 5. 3 426625 T78300 Hs. 300642 serologically defined colon cancer anfig 5. 3 428137 AA421792 Hs. 170999 ESTs 5. 3 428679 AA431765 gb : zw80cO3. s1 Soares_tes6s_NHT Homo sap 5. 3 438176 AW138970 Hs. 122113 ESTs 5. 3 440138 AB033023 Hs. 318127 hypotheticalprotein FLJ10201 5. 3 451018 AW965599 Hs. 247324 mitochondriai ribosomai protein S14 5. 3 416340 N31772 Hs. 79226 fasciculation and elongation protein zet 5. 3 435244 N77221 Hs. 187824 ESTs 5. 3 446035 NM_006558 Hs. 13565 Sam68-like phosphotyrosine protein, T-ST 5. 3 424624 AB032947 Hs. 151301 Ca2+-dependent activator protein for sec 5. 3 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Circadian Oscillat 5. 3 430437 A1768801 Hs. 169943 Homo sapiens cDNA FW 13569 fis, clone PL 5. 3 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 5. 2 453941 U39817 Hs. 36820 Bloom syndrome 5. 2 424998 U58515 Hs. 154138 chitinase 3-like 2 5. 2 423419 R55336 Hs. 23539 ESTs 5. 2 424922 BE386547 Hs. 217112 hypothetical protein MGC10825 5. 2 447359 NM 012093 Hs. 18268 adenylate kinase 5 5. 2 408206 AF041853 Hs. 43670 kinesin family member 3A 5. 2 421013 M62397 Hs. 1345 mutated in colorectal cancers 5. 2 429443 AB028967 Hs. 202687 potassium voitage-gated channel, Shal-re 5. 2 434367 AB020700 Hs. 3830 KIAA0893 protein 5. 2 444861 R46789 Hs. 76118 ubiquifin carboxyl-terminal esterase Ll 5. 2 446142 Api754693 Hs. 145968 ESTs 5. 2 448816 AB033052 Hs. 22151 KIAA1226 protein 5. 2 451050 AW937420 Hs. 69662 ESTs 5. 2 451106 BE382701 Hs. 25960 v-myc avian myelocytomatosis viral relat 5. 2 439285 AL133916 Hs. 172572 hypothetical protein FLJ20093 5. 2 416737 AF154335 Hs. 79691 LIM domain protein 5. 2 424800 AL035588 Hs. 153203 MyoD family inhibitor 5. 2 443695 AW204099 Hs. 337720 ESTs, Weakly similar to AF1267801 retin 5. 2 415257 F03016 Hs. 27513 ESTs 5. 2 433929 A1375499 Hs. 27379 ESTs 5. 1 415651 Api207162 Hs. 3815 stathmin-like-protein RB3 5. 1 451027 AW519204 Hs. 40808 ESTs 5. 1 409172 Z99399 Hs. 118145 ESTs 5. 1 423343 AA324643 Hs. 246106 ESTs 5. 1 429172 AA447417 Hs. 285491 ESTs 5. 1 437268 A1754847 Hs. 227571 regulator of G-protein signalling 4 5. 1 451270 AW341392 Hs. 235795 ESTs 5. 1 452904 AL157581 Hs. 30957 Homo sapiens mRNA ; cDNA DKFZp434E0626 (f 5. 1 420560 AW207748 Hs. 59115 ESTs 5. 1 418097 R45137 Hs. 21868 ESTs 5. 1 442910 Api365130 Hs. 11307 ESTs, Weakly similar to T19326 hypotheti 5. 1 434849 AW292765 Hs. 8053 ESTs 5. 1 413554 AA319146 Hs. 75426 secretogranin D (chromogranin C) 5. 1 414217 Api309298 Hs. 279898 Homo sapiens cDNA : FU23165 fis, clone L 5. 1 412068 S72043 Hs. 73133 metallothionein 3 (growth inhibitory fac 5. 0 413627 BE182082 Hs. 246973 ESTs 5. 0 418661 NM 001949 Hs. 1189 E2F transcription factor 3 5. 0 422438 AA445925 Hs. 270896 ESTs, Moderately similar to Z195 HUMAN Z 5. 0 423728 AW891294 Hs. 132136 solute carrier family 4, sodium bicarbon 5. 0 431431 AL096711 Hs. 252953 HumanDNAsequencefromcloneRP3-403A15 5. 0 435087 AW975241 Hs. 23567 ESTs 5. 0 452097 AB002364 Hs. 27916 a disintegrin-like and metalloprotease (5. 0 410434 AF051152 Hs. 63668 toll-like receptor 2 4. 9 408692 AL040127 Hs. 34074 dipepfidylpepfidase VI 4. 9 407808 AA663559 Hs. 279789 histone deacetylase 3 4. 9 418940 H17739 Hs. 288513 Human DNA sequence from clone RP5-899C14 4. 9 425977 R15138 Hs. 165570 Homo sapiens clone 25052 mRNA sequence 4. 9 426814 AF036943 Hs. 172619 myelin transcrip6on factor 1-like 4. 9 447112 H17800 Hs. 7154 ESTs 4. 9 449574 F05048 Hs. 175373 ESTs 4 9 453652 AW009640 Hs. 28368 ESTs, Moderately similar to S65657 alpha 4. 9 423869 BE409301 Hs. 134012 C1q-relatedfactor 4. 9 413248 T64858 Hs. 21433 hypothetical protein DKFZp547J036 4. 9 449176 A1633545 Hs. 198072 ESTs 4. 9 448451 AW015994 gb : Ul-H-BlOp-abh-g-09-0-Ui. s1 NCI_CGAP_S 4. 8 402604 4. 8 436039 AW023323 Hs. 121070 ESTs 4. 8 448769 N66037 Hs. 38173 ESTs 4. 8 423678 AW963357 Hs. 7847 ESTs 4. 8

439451 AF086270 Hs. 278554 heterochnoma6n-Dke protein 1 4. 8 425870 R13406 Hs. 56782 ESTs 4. 8 408777 U71204 Hs. 47626 Ric (Drosophila)-like, expressed in neur 4. 8 413409 Api638418 Hs. 78580 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 4. 8 413623 AA825721 Hs. 246973 ESTs 4. 8 417246 A1760098 Hs. 21411 ESTs 4. 8 420900 AL045633 Hs. 44269 ESTs 4. 8 424153 AA451737 Hs. 141496 MAGE-like 2 4. 8 443539 A1076182 Hs. 134074 ESTs, ModeratelysimilartoALU6_HUMANA 4. 8 448750 U95020 Hs. 21903 calcium channel, voltage-dependent, beta 4. 8 454030 AW021429 Hs. 231980 ESTs 4. 8 424458 M29273 Hs. 1780 myelin associated glycoprotein 4. 8 444119 R41231 Hs. 184261 ESTs, Weakly similar to T26686 hypotheu 4. 8 407792 A1077715 Hs. 39384 putative secreted ligand homologous to f 4. 8 431462 AW583672 Hs. 256311 granin-like neuroendocdne peptide precu 4. 7 431103 M57399 Hs. 44 pleiotrophin (hepadn binding growth fac 4. 7 429956 A1374651 Hs. 22542 ESTs 4. 7 435060 Api422719 Hs. 233349 ESTs, Weakly similar to fork head like p 4. 7 436203 BE384982 Hs. 5076 Homo sapiens cDNA : FLJ22128 fis, clone H 4. 7 448475 BE613134 Hs. 247474 hypothetical protein FU21032 4. 7 422222 A1699372 Hs. 193247 hypotheüca protein DKFZp434A171 4. 7 431733 AW298410 Hs. 21475 ESTs 47 449353 AA001220 Hs. 271369 ESTs 4. 7 452022 AW072330 Hs. 293875 ESTs 4. 7 454269 A1961060 Hs. 129908 KIAA0591 protein 4. 7 404541 4. 7 428189 AA424030 Hs. 46627 ESTs 4. 7 409125 R17268 Hs. 259873 axonal transport of synaptic vesicles 4. 7 458435 Api418718 Hs. 144121 ESTs, Weakly sirrfilar to T46916 hypotheu 4. 6 425745 U44060 Hs. 14427 Homo sapiens cDNA : FLJ21800 fis, clone H 4. 6 413492 D87470 Hs. 75400 KIAA0280 protein 4. 6 419629 AB020695 Hs. 91662 KIAA0888 protein 4. 6 407638 AJ404672 Hs. 334483 hypothetical protein FLJ23571 4. 6 436140 W87355 Hs. 269587 ESTs 4. 6 439169 A1912122 Hs. 41095 ESTs 46 443150 A1034467 Hs. 34650 ESTs 4. 6 451073 A1758905 Hs. 206063 ESTs 4. 6 451659 BE379761 Hs. 14248 ESTs 4. 6 452106 A1141031 Hs. 21342 ESTs 4. 6 451407 AA131376 Hs. 326401 fibroblast growth factor 12B 4. 6 448765 R15337 Hs. 21958 Homo sapiens mRNA ; cDNADKFZp547D086 (fr 4. 6 430147 R60704 Hs. 234434 hairylenhancer-of-split related with YRP 4. 6 437204 AL110216 Hs. 12285 ESTs, Weakly similar to 155214 salivary 4. 6 431117 AF003522 Hs. 250500 delta (Drosophilarlike 1 4. 5 422175 N79885 Hs. 6382 ESTs, Highly similar to T00391 hypotheti 4. 5 407889 R34556 Hs. 30800 ESTs, Weakly similar to S65657 alpha-1 C-4. 5 419343 AA456245 Hs. 85603 down-regulated by Ctnnbl, a 4. 5 421790 AW896201 Hs. 22654 sodium channel, voltage-gated, type 1, a 4. 5 429399 AA452244 Hs. 16727 ESTs 4. 5 450149 AW969781 Hs. 132863 Zic family member 2 (odd-paired Drosophi 4. 5 453118 AW195849 Hs. 252757 ESTs 4. 5 443455 AB001025 Hs. 9349 ryanodine receptor 3 4. 4 442613 A1004002 Hs. 130522 Kv channel-interacting protein 1 4. 4 429643 AA455889 Hs. 167279 FYVE-finger-containing Rab5 effector pro 4. 4 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h 4. 4 418845 AA852985 Hs. 89232 chromobox homolog 5 (Drosophila HP1 alph 4. 4 435202 A1971313 Hs. 170204 KIAA0551 protein 4. 4 437496 AA452378 Hs. 170144 Homo sapiens mRNA ; cDNADKFZp547J125 (fr 4. 4 451254 A1571016 Hs. 172967 ESTs 4. 4 439039 Api656707 Hs. 48713 ESTs 4. 4 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 4. 4 441607 NM_005010 Hs. 7912 neuronal cell adhesion molecule 4. 4 424983 Ai742434 Hs. 169911 ESTs 4. 4 410611 AW954134 Hs. 20924 KIAA1628 protein 4. 4 402605 4. 4 409248 AB033035 Hs. 51965 KIAA1209 protein 4. 4 442222 A1061301 Hs. 164773 ESTs 4. 4 454027 R40192 Hs. 21527 HumanDNAsequencefnomConeGS1-11SM3 4. 4 454293 H49739 Hs. 134013 ESTs, ModeratelysimiiartoHK61_HUMANH 4. 4 442832 AW206560 Hs. 253569 ESTs 4. 4 407304 AA565832 gb : nj32b03. s1 NCI_CGAP_AA1 Homo sapiens 4. 4 423279 AW959861 Hs. 290943 ESTs 43 427194 AA399018 Hs. 250835 ESTs 4. 3 419723 AL120193 Hs. 92614 longevity assurance (LAG1, S. cerevisiae 4. 3 445810 AW265700 Hs. 155660 ESTs 4. 3 409734 BE161664 Hs. 56155 hypothetical protein 4. 3 410389 AW954049 Hs. 8177 ESTs, WeaklysimilartoPIHUB6salivary 4. 3 411571 AA122393 Hs. 70811 hypotheDcaiproteinFLJ20516 4. 3 433024 AA573847 Hs. 26549 KIAA1708 protein 4. 3 453202 AW085781 Hs. 26270 hypothetical protein FLJ11588 4. 3 425264 AA353953 Hs. 20369 ESTs, Weakly similar to gonadotropin ind 4. 3 416427 BE244050 Hs. 79307 Rac/Cdc42 guanine exchange factor (GEF) 4. 3 431789 H19500 Hs. 269222 mitogen-acfivated protein kinase 4 4. 3

444600 R41398 Hs. 6996 ESTs 4. 3 454042 H22570 Hs. 172572 hypothetical protein FLJ20093 4. 3 441899 Al372588 Hs. 8022 TU3A protein 4. 3 425256 BE297611 Hs. 155392 coliapsin response mediator protein 1 4. 3 410358 AW975168 Hs. 13337 ESTs, Weakly similar to unnamed protein 4. 2 430291 AV660345 Hs. 238126 CGI-49 protein 4. 2 433597 AA708205 Hs. 100343 ESTs 4. 2 444127 N63620 Hs. 13281 ESTs 4. 2 448507 AL133109 Hs. 21333 Homo sapiens mRNA ; cDNA DKFZp566N1047 (f 4. 2 413589 AW452631 Hs. 313803 ESTs, Highly similar to AF1578331 noncl 4. 2 408577 H50572 Hs. 19515 ESTs, Highly similar to NRG3_HUMAN PRO-N 4. 2 409719 Api769160 Hs. 108681 Homo sapiens brain tumor associated prot 4. 2 428536 A1143139 Hs. 2288 visinin-like 1 4. 2 429118 H20669 Hs. 35406 ESTs, Highly similar to unnamed protein 4. 2 432865 Api753709 Hs. 152484 ESTs, Weakly similar to 138022 hypotheg 4. 2 447138 A1439112 Hs. 93828 ESTs, Weakly similar to 2109260A B cell 4. 2 450648 Ai703366 Hs. 26766 ESTs 4. 2 451459 Ai797515 Hs. 270560 ESTs, Moderately similar to ALU7_HUMAN A 4. 2 421686 AB011156 Hs. 106794 KIAA0584 protein 4. 2 452776 AA194540 Hs. 13522 ESTs, Weakly similar to 138022 hypotheti 4. 2 436421 A1678031 Hs. 122813 ESTs, WeaklysimiiartoZN22 HUMANZiNC 4. 2 423858 AL137326 Hs. 133483 Homo sapiens mRNA ; cDNA DKFZp434B0650 (f 4. 2 434001 AW950905 Hs. 3697 serine (or cysteine) proteinase inhibito 4. 2 437380 AL359577 Hs. 112198 HomosapiensmRNA ; cDNADKFZp547M073 (fr 4. 2 432328 A1572739 Hs. 195471 6-phosphofructo-2-kinase/fructose-2, 6-bi 4. 1 439607 BE540565 Hs. 159460 ESTs 4. 1 424028 AF055084 Hs. 153692 Homo sapiens EDNA FU14354 fis, clone Y7 4. 1 446936 H10207 Hs. 47314 ESTs 4. 1 424240 AB023185 Hs. 143535 calcium/calmodulin-dependent protein kin 4. 1 412446 Api768015 Hs. 92127 ESTs 41 409953 AA332277 Hs. 57691 cadherin 18, type 2 4. 1 416220 N49776 Hs. 170994 hypothetical protein MGC10946 4. 1 419683 AA248897 Hs. 48784 ESTs 4. 1 426071 AW138057 Hs. 163835 ESTs 41 428743 AL080060 Hs. 301549 Homo sapiens mRNA ; cDNA DKFZp564H172 (fr 4. 1 432809 AA565509 Hs. 131703 ESTs 4. 1 440105 AA694010 Hs. 6932 Homosapiensclone23809mRNAsequence 4. 1 452039 A1922988 Hs. 172510 ESTs 4. 1 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring finge 4. 1 457561 AA331517 Hs. 286055 chimerin (chimaerin) 2 4. 1 429038 AL023513 Hs. 194766 seizure related gene 6 (mouse)-like 41 433932 AW954599 Hs. 169330 neuronal protein 4. 1 436637 Ai783629 Hs. 26766 ESTs 4. 1 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 4. 1 450530 NM 006668 Hs. 25121 cytochrome P450, subfamily 46 (cholester 4. 1 407721 Y12735 Hs. 38018 dual-specificity tyrosine- (Y)-phosphoryl 4. 1 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-0-sulfot 4. 1 410486 AW235094 Hs. 69233 zinc finger protein 4. 0 413916 N49813 Hs. 75615 apolipoprotein C-I 4. 0 438703 Ai803373 Hs. 31599 ESTs 4. 0 424726 AK001007 Hs. 138760 Homo sapiens cDNA FLJ10145 fis, clone HE 4. 0 405771 4. 0 418841 NM 002332 Hs. 89137 low density lipoprotein-related protein 4. 0 421764 Ai681535 Hs. 148135 serine/ihreonine kinase 33 4. 0 424176 AL137273 Hs. 142307 hypothetical protein 4. 0 425773 N21279 Hs. 237749 ESTs 4. 0 427304 AA761526 Hs. 163853 ESTs 4. 0 428882 AA436915 Hs. 131748 ESTs, Moderately similar to ALU7 HUMAN A 4. 0 452834 A1638627 Hs. 105685 KiAA1688 protein 4. 0 453745 AA952989 Hs. 63908 hypothetical protein MGC14726 4. 0 405239 U89281 Hs. 11958 oxidative 3 alpha hydroxysteroid dehydro 4. 0 413801 M62246 Hs. 35406 ESTs, Highly similar to unnamed protein 4. 0 429698 A1685086 Hs. 26339 ESTs, Weakly similar to S21348 probable 4. 0 435854 AJ278120 Hs. 4996 putative ankyrin-repeat containing prote 4. 0 439199 R40373 Hs. 26299 ESTs 4. 0 439450 R51613 Hs. 125304 ESTs 4. 0 446782 A1653048 Hs. 144006 ESTs 4. 0 419687 Ai638859 Hs. 227699 ESTs, Weakly similar to T2D3_HUMAN TRANS 3. 9 402408 3. 9 453362 H14988 Hs. 107375 ESTs 3. 9 414219 W20010 Hs. 75823 ALL1-fusedgenefromchromosome1q 3. 9 420578 AA813546 Hs. 99034 GTP-binding protein Rho7 3. 9 425010 T16837 Hs. 4241 ESTs 3. 9 444230 H95537 Hs. 146067 ESTs 3. 9 441736 AW292779 Hs. 169799 ESTs 3. 9 418951 F07809 Hs. 89506 paired box gene 6 (aniridia, keratitis) 3. 9 406311 3. 9 408460 AA054726 Hs. 285574 ESTs 3. 9 410658 AW105231 Hs. 192035 ESTs 3. 9 414699 Ai815523 Hs. 76930 synuclein, alpha (non A4 component of am 3. 9 418849 AW474547 Hs. 53565 HomosapiensPiG-MmRNAformannosyltran 3. 9 429477 A1275514 Hs. 6658 ESTs 3. 9 433766 AA609234 Hs. 112669 ESTs 3. 9

436190 AK001059 gb : Homo sapiens cDNA FLJ10197 fis, clone 3. 9 447891 R41754 Hs. 6496 ESTs 3. 9 450221 AA328102 Hs. 24641 cytoskeieton associated protein 2 3. 9 404283 3. 9 453919 AW959912 Hs. 7076 KIAA1705 protein 3. 9 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 3. 9 412754 AW160375 Hs. 74565 amyloid beta (A4) precursor-like protein 3. 9 445314 Ai689948 Hs. 65489 Homo sapiens cDNA : FLJ21517 fis, clone C 3. 9 435652 N32388 Hs. 334370 uncharacterized hypothalamus protein HBE 3. 9 407378 AA299264 Hs. 57776 ESTs, Moderately similar to 138022 hypot 3. 9 438054 AA776626 Hs. 62183 ESTs 3. 9 436420 AA443966 Hs. 31595 ESTs 3. 9 445133 AW157646 Hs. 153506 ESTs 3. 9 432590 Ai609273 Hs. 110783 ESTs 3. 9 453331 Ai240665 Hs. 8895 ESTs 3. 9 410227 AB009284 Hs. 61152 exostoses (mul6ple)-like 2 3. 8 424635 AA420687 Hs. 115455 HomosapienscDNAFW14259fis, donePL 3. 8 451489 NM_005503 Hs. 26468 amyloid beta (A4) precursor protein-bind 3. 8 447247 AW369351 Hs. 287955 Homo sapiens cDNA FLi13090 fis, cione NT 3. 8 448302 AI480208 Hs. 182906 Homo sapiens mRNA for KIAA1872 protein, 3. 8 415669 NM_005025 Hs. 78589 serine (or cysteine) proteinase inhibito 3. 8 417355 D13168 Hs. 82002 endothelin receptor type B 3. 8 446727 AB011095 Hs. 16032 KIAA0523 protein 3. 8 424340 AA339036 Hs. 7033 ESTs 3. 8 423346 A1267677 Hs. 127416 synaptojanin 1 3. 8 412788 AA120960 Hs. 198416 ESTs 3. 8 404593 3. 8 416856 N27833 Hs. 269028 ESTs, Weakly similar to 138022 hypotheu 3. 8 429896 AA460367 Hs. 224223 ESTs, Moderately similar to 138022 hypot 3. 8 439619 AW975998 Hs. 58595 ESTs, Weakly similar to 138022 hypotheti 3. 8 439634 W79377 Hs. 167 microtubule-associated protein 2 3. 8 440322 AA879430 gb : oj91dO8. s1 Soares_NFL_T_GBC_S1 Homos 3. 8 447761 AF061573 Hs. 19492 protocadherin 8 3. 8 452453 Ai902519 gb : QV-BT009-101198-051BT009Homosapien 3. 8 439671 AW162840 Hs. 6641 kinesin family member 5C 3. 8 447937 AL109716 Hs. 20034 Homo sapiens mRNA full length insert cDN 3. 8 459278 AW294659 Hs. 34054 Homo sapiens cDNA : FLJ22488 fis, clone H 3. 8 447028 AI973128 Hs. 167257 brain link protein-1 3. 8 449458 Ai805078 Hs. 208261 ESTs 3. 8 445888 AF070564 Hs. 13415 Homo sapiens clone 24571 MRNA sequence 3. 8 407385 AA610150 Hs. 272072 ESTs, Weakly similar to 138022 hypotheti 3. 8 428841 Ai418430 Hs. 104935 ESTs 3. 8 430643 AW970065 Hs. 287425 MEGF10 protein 3. 8 422263 AA307639 Hs. 129908 KIAA0591 protein 3. 8 451625 R56793 Hs. 106576 alanine-giyoxylate aminotransferase 2-ii 3. 8 439236 BE160952 Hs. 247117 ESTs, Moderately similar to ALUF_HUMAN ! 3. 8 441928 Api370188 Hs. 211454 ESTs 3. 8 441797 A ! 936933 Hs. 214635 ESTs 3. 7 414922 D00723 Hs. 77631 glycine cleavage system protein H (amino 3. 7 425588 F07396 Hs. 46751 ESTs 3. 7 437007 AA741300 Hs. 202599 ESTs, Weakly similar to 138022 hypotheu 3. 7 435793 AB037734 Hs. 4993 KIAA1313 protein 3. 7 443682 Api383061 Hs. 47248 ESTs, Highly similar to similar to Cdc14 3. 7 425741 AF052152 Hs. 159412 Homo sapiens clone 24628 mRNA sequence 3. 7 418211 BE244746 Hs. 247474 hypothetical protein FLJ21032 3. 7 440080 AW051597 Hs. 143707 ESTs 3. 7 452898 AA814497 Hs. 78792 ESTs 3. 7 435575 AF213457 Hs. 44234 triggering receptor expressed on myeloid 3. 7 409234 Ai879419 Hs. 27206 ESTs 3. 7 420489 AA815089 Hs. 193513 ESTs 3. 7 426890 AA393167 Hs. 41294 ESTs 3. 7 438849 W28948 Hs. 10762 ESTs 3. 7 441869 NM 003947 Hs. 8004 huntingtin-associated protein interactin 3. 7 448796 AA147829 Hs. 301431 endothelial zinc finger protein induced 3. 7 459318 NM 000038 gb : Homo sapiens adenomatosis polyposis c 3. 7 459518 A1937419 Hs. 294069 Homo sapiens CDNA FLJ 13384 fis, clone PL 3. 7 434444 Ai765276 Hs. 101257 hypothetical protein MGC3295 3. 7 421183 AL135740 Hs. 102447 TSC-22-iike 3. 7 410555 U92649 Hs. 64311 a disintegrin and metalioproteinase doma 3. 7 421637 AF035290 Hs. 106300 Homo sapiens clone 23556 mRNA sequence 3. 7 418522 AA605038 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 3. 7 420807 AA280627 Hs. 57846 ESTs 3. 7 449961 AW265634 Hs. 133100 ESTs 3. 7 422634 Nom016010 Hs. 118821 CGI-62 protein 3. 7 421030 AW161357 Hs. 101174 microtubule-associated protein tau 3. 7 427099 AB032953 Hs. 173560 odd Oz/ten-m homolog 2 (Drosophiia, mous 3. 7 452355 N54926 Hs. 29202 G protein-coupled receptor 34 3. 7 440483 A1200836 Hs. 150386 ESTs 3. 7 429597 NM_003816 Hs. 2442 adisintegrinandmetailoproteinasedoma 3. 7 423756 AA828125 gb : od7 a09. s1 NCI_CGAP_Ov2 Homo sapiens 3. 6 425187 AW014486 Hs. 22509 ESTs 3. 6 434859 BE255080 Hs. 299315 collapsin response mediator protein-5 ; C 3. 6 413199 M62843 Hs. 75236 ELAV (embryonic lethal, abnormal vision, 3. 6

445729 H21066 Hs. 13223 Homo sapiens mRNA full length insert cDN 3. 6 416120 H46739 gb : yo14hO2. s1 Scares aduit brain N2b5HB5 3. 6 429239 AA448419 Hs. 45209 ESTs 3. 6 419086 NM 000216 Hs. 89591 Kalimann syndrome 1 sequence 3. 6 446659 Ai335361 Hs. 226376 ESTs 3. 6 426757 AW205640 Hs. 158206 ESTs 3. 6 418819 AA228776 Hs. 191721 ESTs 3. 6 458332 A1000341 Hs. 220491 ESTs 3. 6 408826 AF216077 Hs. 48376 Homo sapiens clone HB-2 mRNA sequence 3. 6 410343 AA084273 Hs. 76561 ESTs, Weakly similar to S47072 finger pr 3. 6 410507 AA355288 Hs. 40834 transi6onal epithelia response protein 3. 6 422977 AA631498 gb : np83hO4. s1 NCi_CGAP_Thy1 Homosapiens 3. 6 425305 AA363025 Hs. 155572 Human clone 23801 mRNA sequence 3. 6 428002 AA418703 gb : zv98c03. s1 Soares_NhHMPu_S1 Homosapi 3. 6 428505 AL035461 Hs. 2281 chromogranin B (secretogranin 1) 3. 6 430530 AA480870 Hs. 47660 ESTs 3. 6 436425 Ai913146 Hs. 318725 CGI-72 protein 3. 6 438078 A1016377 Hs. 131693 ESTs 3. 6 442927 Ai024347 Hs. 131519 ESTs 3. 6 446242 N66336 Hs. 7360 ESTs 3. 6 448831 AL080123 Hs. 22182 zinc finger protein 23 (KOX 16) 3. 6 450474 AW872844 Hs. 201919 ESTs 3. 6 452198 A1097560 Hs. 61210 ESTs, Weakly similar to 138022 hypothefi 3. 6 455800 R22479 Hs. 167073 Homo sapiens cDNA FLJ13047 fis, clone NT 3. 6 436443 AW138211 Hs. 128746 ESTs 3. 6 426514 BE616633 Hs. 170195 bone morphogenetic protein 7 (osteogenic 3. 6 456038 AA203285 Hs. 294141 ESTs, Weakly similar to alternatively sp 3. 6 408902 AW014869 Hs. 5510 ESTs 3. 6 442950 A1500417 Hs. 46764 ESTs 3. 6 423905 AW579960 Hs. 135150 lungbpe-icelimembrane-associatedgìy 3. 6 425478 AB007953 Hs. 268840 ESTs 3. 6 453884 AA355925 Hs. 36232 KIAA0186 gene product 3. 6 404721 3. 6 408453 AI369836 Hs. 45127 chondroitin sulfate proteoglycan 5 (neur 3. 6 440553 AA889416 Hs. 295362 Homo sapiens cDNA FLJ14459 fis, clone HE 3. 5 446372 AB020644 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 3. 5 413999 N46124 Hs. 34460 ESTs 3. 5 421458 NM_003654 Hs. 104576 carbohydrate (keratan sulfate Gal-6) sul 3. 5 425017 AL119305 Hs. 288405 ESTs 3. 5 435958 H98180 Hs. 117975 ESTs 3. 5 415101 R45531 Hs. 144534 ESTs 3. 5 451320 AW118072 Hs. 89981 diacylglycerol kinase, zeta (104kD) 3. 5 430290 A1734110 Hs. 136355 ESTs 3. 5 416836 D54745 Hs. 80247 chotecystokinin 3. 5 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 3. 5 419412 AW161058 Hs. 90297 synudein, beta 3. 5 437860 AA333063 Hs. 279898 Homo sapiens cDNA : FU23165 fis, clone L 3. 5 452689 F33868 Hs. 284176 transferrin 3. 5 416661 AA634543 Hs. 79440 IGF-D mRNA-binding protein 3 3. 5 427491 R43279 Hs. 22574 ESTs, Weakly similar to 138022 hypothe6 3. 5 428037 N47474 Hs. 89230 potassium intermediatelsmall conductance 3. 5 444584 A1168422 gb : ok30e11. x1 Soares_NSF_F8_9W_OT_PA_P_S 3. 5 408296 AL117452 Hs. 44155 DKFZP586G1517 protein 3. 5 453775 NM_002916 Hs. 35120 replication factor C (activator 1) 4 (37 3. 5 412659 AW753865 Hs. 74376 olfactomedin related ER localized protei 3. 5 429077 AB028983 Hs. 2352 adenylate cyclase 2 (brain) 3. 5 436887 AW953157 Hs. 193235 hypothetical protein DKFZp547D155 3. 5 450784 AW246803 Hs. 47289 ESTs 3. 5 446827 AW451243 Hs. 157069 ESTs 3. 5 436434 N50465 Hs. 92927 putative 47 kDa protein 3. 5 412777 A1335773 Hs. 270123 ESTs 3. 5 436476 AA326108 Hs. 33829 bHLH protein DEC2 3. 5 408601 U47928 Hs. 86122 protein A 3. 4 429401 AW296102 Hs. 99272 ESTs, Weakly similar to S32567 A4 protei 3. 4 448425 Ai500359 Hs. 233401 ESTs 3. 4 418727 AA227609 Hs. 94834 ESTs 3. 4 451729 AW160725 Hs. 312469 ESTs 3. 4 435910 A1084152 Hs. 21782 ESTs, Weakly simiiar to AW7_HUMAN ALU S 3. 4 434577 R37316 Hs. 179769 HomosapienscDNA : FU22487 fis, clone H 3. 4 414598 A1094221 Hs. 135150 lung type-I ceil membrane-associated gly 3. 4 439627 BE621702 Hs. 29076 hypothetical protein FLJ21841 3. 4 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 3. 4 423992 AW898292 Hs. 137206 Homo sapiens mRNA ; cDNA DKFZp564H1663 (f 3. 4 426249 F05422 Hs. 168352 nucleopodn-like protein 1 3. 4 426968 U07616 Hs. 173034 amphiphysin (Stiff-Mannsyndromewithbr 14 430388 AA356923 Hs. 240770 nuclear cap binding protein subunit 2, 2 3. 4 435061 AI651474 Hs. 163944 ESTs 3. 4 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7, S. cerevisi 3. 4 449714 AB033015 Hs. 23941 KiM1189protein 34 443392 A1055821 Hs. 293420 ESTs 3. 4 410082 AA081594 Hs. 158311 Musashi (Drosophila) homo1 3. 4 445337 NM013280 Hs. 12523 fibronectin ieucine rich transmembrane p 3. 4 408493 BE206854 Hs. 46039 phosphoglycerate mutase 2 (muscle) 3. 4

432731 R31178 Hs. 287820 fibronectin 1 3. 4 448758 AB018311 Hs. 21917 KIAA0768 protein 3. 4 432613 AW081698 Hs. 80712 KIAA0202 protein 3. 4 434164 AW207019 Hs. 148135 serine/threoninekinase33 3. 4 425294 AF033827 Hs. 155553 HNK-1 sulfotransferase 3. 4 410108 AA081659 Hs. 318775 OSBP-reiated protein 6 3. 4 406815 AA833930 Hs. 288036 tRNAisopentenyipyrophosphatetransferas 3. 4 402855 3. 3 422170 AI791949 Hs. 112432 anG-Mullerian hormone 3. 3 445034 AW293376 Hs. 143659 ESTs 3. 3 424378 W28020 Hs. 167988 neural cell adhesion molecule 1 3. 3 423611 AB011163 Hs. 129908 KIAA0591 protein 3. 3 435593 R88872 Hs. 4964 DKFZP586J1624 protein 3. 3 404819 3. 3 436607 AW661783 Hs. 211061 ESTs 3. 3 427315 AA179949 Hs. 175563 Homo sapiens mRNA ; cDNA DKFZp564N0763 (f 3. 3 452693 T79153 Hs. 48589 zinc finger protein 228 3. 3 454996 AW850180 gb : IL3-CT0219-271099-022-C09 CT0219 Homo 3. 3 406927 M26460 gb : Homo sapiens (clone 104) reUnoblasto 3. 3 409045 AA635062 Hs. 50094 Homo sapiens mRNA ; cDNA DKFZp43400515 (f 3. 3 415238 R37780 Hs. 21422 ESTs 3. 3 417845 AL117461 Hs. 82719 Homo sapiens mRNA ; cDNA DKFZp586F1822 (f 3. 3 421192 AA833718 Hs. 204529 KIAA1806 protein 3. 3 426695 AW118191 Hs. 112729 ESTs 3. 3 438885 Api886558 Hs. 184987 ESTs 3. 3 451762 AF222980 Hs. 26985 disrupted in schizophrenia 1 3. 3 452103 R42764 Hs. 339654 ESTs, Weakly similar to 138022 hypotheti 3. 3 453590 AF150278 Hs. 33578 KIAA0820 protein 3. 3 453616 NM_003462 Hs. 33846 dynein, axonemal, light intermediate pol 3. 3 457285 A1038858 Hs. 130522 Kv channel-interacting protein 1 3. 3 436045 AB037723 Hs. 5028 DKFZP56400423 protein 3. 3 437470 AL390147 Hs. 134742 hypothe6cai protein DKFZp547D065 3. 3 448520 AB002367 Hs. 21355 doubiecortin and CaM kinase-Dke 1 3. 3 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel 3. 3 432656 NM 000246 Hs. 3076 MHC class II transactivator 3. 3 443898 AW804296 Hs. 9950 Sec61 gamma 3. 3 423582 BE000831 Hs. 23837 Homo sapiens cDNA FU11812 fis, cloneHE 3. 3 445953 Api612775 Hs. 145710 ESTs 3. 3 427940 AA417812 Hs. 38775 ESTs 3. 3 414683 S78296 Hs. 76888 hypothetical protein MGC12702 3. 3 428484 AF104032 Hs. 184601 solute carrier family 7 (cationic amino 3. 3 420649 A1866964 Hs. 124704 ESTs, Moderately similar to S65657 alpha 3. 3 419498 AL036591 Hs. 20887 hypothetical protein FLJ10392 3. 3 457579 AB030816 Hs. 36761 HRAS-like suppressor 3. 3 436556 A1364997 Hs. 7572 ESTs 3. 2 424369 R87622 Hs. 26714 KIAA1831 protein 3. 2 457065 A1476318 Hs. 192480 ESTs 3. 2 440210 AW674562 Hs. 125296 ESTs 3. 2 444513 AL120214 Hs. 7117 glutamate receptor, ionotropic, AMPA 1 3. 2 434353 AA630863 Hs. 131375 ESTs, Moderately similar to ALUB_HUMAN ! 3. 2 414430 Api346201 Hs. 76118 ubiquitincarboxyi-terminaiesteraseL1 3. 2 439924 Ai985897 Hs. 125293 ESTs 3. 2 411505 AF155659 Hs. 70565 molybdenum cofactor synthesis 2 3. 2 423175 W27595 Hs. 18653 hypothetical protein FLJ14627 3. 2 415115 AA214228 Hs. 127751 hypothetical protein 3. 2 407878 D87468 Hs. 40888 activity-regulated cytoskeleton-associat 3. 2 410274 AA381807 Hs. 61762 hypoxia-inducible protein 2 3. 2 437762 T78028 Hs. 154679 synaptotagmin 1 3. 2 438944 AA302517 Hs. 92732 KIAA1444 protein 3. 2 450313 A1038989 Hs. 332633 Bardet-Biedlsyndrome2 3. 2 409459 D86407 Hs. 54481 low density lipoprotein receptor-related 3. 2 410953 AW811766 Hs. 334858 hypothetical protein MGC12250 3. 2 418527 AA450386 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 3. 2 420081 AW510776 Hs. 94958 tubulin tyrosine ligase-like 1 3. 2 429496 AA453800 Hs. 192793 ESTs 3. 2 430099 AW194988 Hs. 20537 hypothetical protein FLJ13942 3. 2 434928 AW015595 Hs. 4267 Homo sapiens clones 24714 and 24715 mRNA 3. 2 435532 AW291488 Hs. 117305 Homo sapiens, cione IMAGE : 3682908, mRNA 3. 2 438306 AW188266 Hs. 163645 ESTs 3. 2 439274 AF086092 Hs. 48372 ESTs 3. 2 440847 AA907511 Hs. 130178 ESTs 3. 2 447750 A1422234 Hs. 143434 contain 1 3. 2 455350 AW901809 gb : QVO-NN1020-170400-195-hO2 NN1020 Homo 3. 2 430890 X54232 Hs. 2699 glypican 1 3. 2 420568 F09247 Hs. 247735 protocadherin alpha 10 3. 2 410768 AF038185 Hs. 66187 Homo sapiens clone 23700 mRNA sequence 3. 2 427450 AB014526 Hs. 178121 KIAA0626 gene product 3. 2 430456 AA314998 Hs. 241503 hypothetical protein 3. 2 430181 AF065314 Hs. 234785 cyclic nucleotide gated channel alpha 3 3. 2 418512 AW498974 Hs. 89981 diacylglycerol kinase, zeta (104kD) 3. 2 419912 AF249745 Hs. 6066 Rho guanine nucleotide exchange factor (3. 2 450689 Api369275 Hs. 243010 Homo sapiens cDNA FLJ14445 fis, clone HE 3. 2 424899 AL119387 Hs. 119062 ESTs 3. 2

436277 R88520 Hs. 120917 ESTs 3. 2 451455 Api937227 Hs. 8821 hepcidin antimicrobial peptide 3. 2 445078 Api869975 Hs. 4775 junctophilin 3 3. 2 447746 AW015920 Hs. 161359 ESTs 3. 2 435458 F11872 Hs. 4892 Homo sapiens clone 24841 mRNA sequence 3. 2 427729 AB033100 Hs. 300646 KIAA protein (similar to mouse paladin) 3. 2 417417 F05745 Hs. 89512 ATPase, Ca-transporting, plasma membra 3. 1 438810 AW897846 Hs. 6421 hypothetical protein DKFZp761N09121 3. 1 439570 T79925 Hs. 269165 ESTs, WeaklysimilartoAWl_HUMANALUS 3. 1 432527 AW975028 Hs. 102754 ESTs 3. 1 416801 X98834 Hs. 79971 sat (Drosophila)-like 2 3. 1 421988 AW450481 Hs. 161333 ESTs 3. 1 426509 M31166 Hs. 2050 pentaxin-related gene, rapidly induced b 3. 1 408786 AA773187 Hs. 294027 ESTs 3. 1 433494 AB029396 Hs. 3353 beta-1, 3-glucuronyltransferase t (glucur 3. 1 412723 AA648459 Hs. 335951 hypothetical protein AF301222 3. 1 418329 AW247430 Hs. 84152 cystathionine-beta-synthase 3. 1 439456 Ai752409 Hs. 109314 hypothetical protein FU20980 3. 1 428832 AA578229 Hs. 324239 ESTs, Moderately similar to ZN91 HUMAN Z 3. 1 452780 BE171598 Hs. 13522 ESTs, Weakly similar to 138022 hypotheu 3. 1 438192 Ai859065 Hs. 337620 HomosapiensAFG3L1isofomm1mRNA, part 3. 1 424939 AK000059 Hs. 153881 Homo sapiens NY-REN-62 antigen mRNA, par 3. 1 403053 R58624 Hs. 2186 eukaryotictransiationetongation factor 3. 1 404299 3. 1 407864 AF069291 Hs. 40539 chromosome 8 open reading frame 1 3. 1 410181 At468210 Hs. 261285 pleiotropic regulator I (PRLI, Arabidops 3. 1 418852 BE537037 Hs. 273294 hypothetical protein FLJ20069 3. 1 449101 AA205847 Hs. 23016 G protein-coupled receptor 3. 1 453240 Ai969564 Hs. 166254 hypothetical protein DKFZp566t133 3. 1 440486 BE243513 Hs. 7212 hypothetical protein PP1044 3. 1 408096 BE250162 Hs. 83765 dihydrofolate reductase 3. 1 439864 Ai720078 Hs. 291997 ESTs, Weakly similar to A47582 B-cell gr 3. 1 414706 AW340125 Hs. 76989 KIAA0097 gene product 3. 1 436315 BE390513 Hs27935 hypothetical protein MGC4837 3. 1 426855 AL117427 Hs. 172778 Homo sapiens mRNA ; cDNA DKFZp566P013 (fr 3. 1 425683 AB037813 Hs. 159200 hypothetical protein DKFZp762K222 3. 1 410126 BE169274 Hs. 169387 KIAA0036 gene product 3. 1 435312 AJ243396 Hs. 4865 voltage-gatedsodiumchannelbeta4subu 3. 1 425491 AA883316 Hs. 255221 ESTs 3. 1 456273 AF154846 Hs. 1148 Zinc finger protein 3. 1 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 3. 1 445255 NM 014841 Hs. 12477 synaptosomal-associated protein, 91 kDa 3. 1 432154 A1701523 Hs. 112577 ESTs 3. 1 453128 AW026516 Hs. 31791 acylphosphatase 2, muscle type 3. 1 438458 AW975186 gb : EST387294 MAGE resequences, MAGN Homo 3. 1 448616 AF035621 Hs. 21611 kinesin family member 3C 3. 0 429281 AA830856 Hs. 29808 Homo sapiens cDNA : FLJ21122 fis, clone C 3. 0 443906 AA348031 Hs. 7913 ESTs 3. 0 417318 AW953937 Hs. 12891 ESTs 3. 0 452619 AW298597 Hs. 61884 Homo sapiens, clone MAGE : 4298026, mRNA, 3. 0 444153 AK001610 Hs. 10414 hypothetical protein FLJ10748 3. 0 408790 AW580227 Hs. 47860 neurotrophic tyrosine kinase, receptor, 3. 0 426327 W03242 Hs. 44898 HomosapiensdoneTCCCTA00151 mRNAsequ 3. 0 451468 AW503398 Hs. 293663 ESTs, Moderately similar to 138022 hypot 3. 0 422758 AF152329 Hs. 284180 protocadherin gamma subfamily C, 3 3. 0 421633 AF121860 Hs. 106260 sorting nexin 10 3. 0 428361 NM 015905 Hs. 183858 transcriptional intermediary factor 1 3. 0 418932 L34059 Hs. 89484 cadherin #pe1, R-cadherin (re6nai) 3. 0 416805 F13271 Hs. 79981 Human clone 23560 mRNA sequence 3. 0 419518 U79289 Hs. 90798 Human clone 23695 MRNA sequence 3. 0 422709 AA315331 Hs. 153485 ESTs 3. 0 423135 N67655 Hs. 26411 ESTs 3. 0 424901 Z11933 Hs. 182505 POU domain, class 3, transcription facto 3. 0 426617 W58006 Hs. 266258 endonuCease G-6ke 1 3. 0 427386 AW836261 Hs. 337717 ESTs 3. 0 429859 NM_007050 Hs. 225952 protein tyrosine phosphatase, receptor t 3. 0 435071 D60683 Hs. 35495 ESTs 3. 0 435092 AL137310 Hs. 4749 HomosapiensmRNA cDNADKFZp761E13121 (3. 0 436211 AK001581 Hs. 334828 hypothetical protein FLJ10719 ; KIAA1794 3. 0 436936 AL134451 Hs. 197478 ESTs 3. 0 445855 BE247129 Hs. 145569 ESTs 3. 0 452294 A1871925 Hs. 117895 ESTs, ModeratelysimilartoA47582B-cel 3. 0 433980 AA137152 Hs. 286049 phosphoserine aminotransferase 3. 0 430228 AW950939 Hs. 6382 ESTs, Highly similar to T00391 hypothe6 3, 0 451026 AA013218 Hs. 157492 cer-d4 (mouse) homolog 3. 0 435232 NM001262 Hs. 4854 cyclin-dependent kinase inhibitor 2C (p1 3. 0 439566 AF086387 gb : Homo sapiens full length insert cDNA 3. 0 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 3. 0 416586 D44643 Hs. 14144 secreted modular calcium-binding protein 3. 0 416874 H98752 Hs. 42568 ESTs 3. 0 410386 W26187 Hs. 3327 Homo sapiens cDNA : FU22219 fis, clone H 3. 0 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIM1330 pnotein 3, 0 424066 Z99348 Hs. 112461 ESTs, Weakly similar to i38022 hypotheti 3. 0

404048 3. 0 429163 AA884766 gb : am20a10. s1SoaresNFLTGBCS1 Homos 3. 0 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 3. 0 418196 Api745649 Hs. 26549 KIAA1708 protein 3. 0 434131 Ai858275 Hs. 143659 ESTs 3. 0 441255 R06350 Hs. 171635 ESTs 2. 9 453900 AW003582 Hs. 226414 ESTs, WeaklysimDartoALU8 HUMANALUS 2. 9 453905 NM 002314 Hs. 36566 LIM domain kinase 1 2. 9 416602 NM 006159 Hs. 79389 net (chicken)-like 2 2. 9 431173 AW971198 Hs. 294068 ESTs 2. 9 425599 AW366745 Hs. 214140 ESTs, WeakiysimiiartoALU1_HUMANAWS 2. 9 436401 A) 087958 Hs. 29088 ESTs 2. 9 422960 AW890487 Hs. 63984 cadherin 13, H-cadherin (heart) 2. 9 451558 NM001089 Hs. 26630 ATP-binding cassette, sub-family A (ABC1 2. 9 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 2. 9 433149 BE257672 Hs. 42949 hypothetical protein HES6 2. 9 434811 AW971205 Hs. 114280 ESTs 2. 9 425897 AA935315 Hs. 48965 Homo sapiens cDNA : FLJ21693 fis, clone C 2. 9 452092 BE245374 Hs. 27842 hypothetical protein FLJ11210 2. 9 453496 AA442103 Hs. 33084 solute carrierfamily 2 (facilitated glu 2. 9 411124 AW196937 Hs. 53929 ESTs, WeaklysimilartoALUB_HUMANiii ! 29 419227 BE537383 Hs. 89739 cholinergic receptor, nicotinic, beta po 2. 9 427651 AW405731 Hs. 18498 Homo sapiens cDNA FLJ12277 fis, clone MA 2. 9 441707 R42637 Hs. 21963 hypothetical protein DKFZp761B0514 2. 9 435741 Ai240668 Hs. 113099 ESTs 2. 9 437273 AL137451 Hs. 120873 ESTs, Highly similar to T46266 hypotheri 2. 9 422939 AW394055 Hs. 98427 ESTs, Weakly similar to 138022 hypotheti 2. 9 439376 AA883521 Hs. 222064 ESTs 2. 9 439935 S75105 Hs. 301676 glutamate receptor, ionotropic, kainate 2. 9 437267 AW511443 Hs. 258110 ESTs 2. 9 453740 AL120295 Hs. 311809 ESTs, ModeratetysimilartoPC4259ferri 2. 9 400250 2. 9 400992 2. 9 408814 N62499 Hs. 176227 hypothetical protein FLJ11155 2. 9 411849 AW964970 Hs. 18861 ESTs, Moderately similar to KIAA1276 pro 2. 9 414853 U31116 Hs. 77501 sarcoglycan, beta (43kD dystrophin-assoc 2. 9 423751 AW235633 Hs. 46525 ESTs 2. 9 426910 AA470023 Hs. 190089 ESTs, ModeratelysimilartoALU1 HUMANA 2. 9 450203 AF097994 Hs. 301528 L-kynurenine/alpha-aminoadipate aminotra 2. 9 459311 R40192 Hs. 21527 Human DNA sequence from cione GS1-11 SM3 2. 9 425304 AA463844 Hs. 31339 fibroblast growth factor 11 2. 9 428500 Api815395 Hs. 184641 fatty acid desaturase 2 2. 9 421641 Api638184 Hs. 106334 Homo sapiens clone 23836 mRNA sequence 2. 9 421141 AW117261 Hs. 125914 ESTs 2. 9 407870 AB032990 Hs. 40719 hypothetical protein KIAA1164 2. 9 456723 Z43902 Hs. 4748 adenylate cyclase activa6ng polypeptide 2. 9 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 2. 9 421483 NM 003388 Hs. 104717 hypothetical protein MGC11333 2. 9 412190 R16180 Hs. 274461 ESTs 2. 9 446131 NM 000929 Hs. 290 phospholipase A2, group V 2. 9 441668 A1611973 Hs. 127525 ESTs 2. 9 437387 A1198874 Hs. 28847 AD026 protein 2. 9 423420 A1571364 Hs. 128382 Homo sapiens mRNA ; cDNA DKFZp76111224 (f 2. 9 427958 AA418000 Hs. 98280 potassium intermediate/small conductance 2. 9 429084 AJ001443 Hs. 195614 splicing factor 3b, subunit 3, 130kD 2. 9 447067 R42098 Hs. 21964 ESTs 2. 9 430887 N66801 Hs. 260287 KIAA1841 protein 2. 9 441824 AB007871 Hs. 7977 KIAA0411 gene product 2. 9 424126 AA335635 Hs. 96917 ESTs 2. 9 408739 W01556 Hs. 238797 ESTs, Moderately similar to 138022 hypot 2. 9 447422 BE618703 Hs. 98258 orthopedia (Drosphila) homolog 2. 9 435615 Y15065 Hs. 4975 potassium voltage-gated channel, KQT-lik 2, 9 446997 AA383439 Hs. 16758 Seir-1 protein 2. 9 433573 AF234887 Hs. 57652 cadherin, EGF LAG seven-pass G-type rece 2. 9 408447 AK002089 Hs. 45080 Homo sapiens cDNA FLJ 11227 fis, clone PL 2. 9 419586 A1088485 Hs. 144759 ESTs, Weakly similar to 138022 hypotheti 2. 8 417022 NM 014737 Hs. 80905 Ras association (RaIGDS/AF-6) domain fam 2. 8 408432 AW195262 gb : xn67bO5. x1 NCI_CGAP_CML1 Homo sapiens 2. 8 420320 AB002361 Hs. 96633 KIAA0363 protein 2. 8 425241 AA324624 Hs. 155247 aldolase C, fructose-bisphosphate 2. 8 428670 AA431682 Hs. 134832 ESTs 2. 8 424415 NM_001975 Hs. 146580 enolase 2, (gamma, neuronal) 2. 8 409185 AW961601 Hs. 252406 hypothetical protein FLJ12296 similar to 2. 8 411555 AF113537 Hs. 70669 HMP19 protein 2. 8 426847 S78723 Hs. 298623 5-hydroxytryptamine (serotonin) receptor 2. 8 458809 AW972512 Hs. 20985 sin3-associated polypeptide, 30kD 2. 8 420071 AB028985 Hs. 94806 ATP-binding cassette, sub-family A (ABC1 2. 8 424572 M19650 Hs. 150741 Z, 3-cyclicnucieo6de3 phosphodieste 2. 8 444670 H58373 Hs. 332938 hypothetical protein MGC5370 2. 8 411089 AA456454 Hs. 183418 cell division cycle 2-like 1 (PITSLRE pr 2. 8 416111 AA033813 Hs. 79018 chromatinassembtyfeCor1, subunitA 2. 8 440637 AW900115 Hs. 7309 Homo sapiens clone 23741 mRNA sequence 2. 8 408554 AA836381 Hs. 315111-nuclear receptor co-repressor/HDAC3 comp 2. 8

403056 R58624 Hs. 2186 eukaryotic translation elongation factor 2. 8 423449 A1497900 Hs. 33067 ESTs 2. 8 424188 AW954552 Hs. 142634 zinc finger protein 2. 8 429006 AA443143 Hs. 50929 hypothe6cal protein FLJ13842 2. 8 434981 AW182577 Hs. 293077 ESTs 2. 8 437435 AA249439 Hs. 27027 hypotheticalprotein DKFZp762H1311 2. 8 442748 A1016713 Hs. 135787 ESTs 2. 8 443312 N52025 Hs. 46616 ESTs 2. 8 450940 Api744943 Hs. 143209 ESTs, Weakly simiiar fo i38022 hypothe6 2. 8 452738 AL133800 Hs. 7086 hypothetical protein MGC12435 2. 8 409182 AA064970 Hs. 118145 ESTs 2. 8 439793 AA018825 Hs. 7934 Kruppel-like factor 4 (gut) 2. 8 432683 AW995441 Hs. 10475 ESTs 2. 8 434269 AK001991 Hs. 3781 similartomurineieucine-richrepeatpr 2. 8 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactin) 2. 8 433290 R20077 Hs. 302185 Homo sapiens clone 23618 mRNA sequence 2. 8 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 2. 8 435977 AL138079 Hs. 5012 brain-specific membrane-anchored protein 2. 8 430294 A1538226 Hs. 32976 guanine nucleotide binding protein 4 2. 8 425168 R96366 gb : yq37dO4. s1 Soaresfetalliverspleen 2. 8 428180 A1129767 Hs. 182874 guanine nucleotide binding protein (G pr 2. 8 409348 A1401535 Hs. 146090 ESTs 2. 8 409887 AL137534 Hs. 56876 Homo sapiens mRNA ; cDNA DKFZp434H1419 (f 2. 8 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 2. 8 430039 BE253012 Hs. 153400 ESTs, WeakEysimiiarfoAW1_HUMANALUS 2. 8 417642 BE302665 Hs. 105461 hypotheticalprotein FLJ20357 2. 8 419169 AW851980 Hs. 262346 ESTs, Weakly similar to S72482 hypotheft 2. 8 434008 AA740878 Hs. 112982 ESTs 2. 8 446776 AW293417 Hs. 156455 ESTs 2. 8 408838 Api669535 Hs. 40369 ESTs 2. 8 422565 BE259035 Hs. 118400 singed (Drosophila)-Dke (seaunchinfas Z8 447397 BE247676 Hs. 18442 E-1 enzyme 2. 8 412530 AA766268 Hs. 266273 hypothetical protein FLJ13346 2. 8 424330 AW073953 Hs. 333396 Homo sapiens cDNA FLJ13596 fis, cione PL 2. 8 446377 AW014022 Hs. 170953 ESTs 2. 8 458924 BE242158 Hs. 24427 DKFZP56601646 protein 2. 8 447710 A1420523 Hs. 328241 ESTs 2. 8 404049 Z8 416913 AW934714 gb : RC1-DT0001-031299-011-a11 DT0001 Homo 2. 8 426400 M78361 Hs. 169743 Homo sapiens clone 25121 neuronal olfact 2. 8 413264 W26456 Hs. 134757 hypothetical protein FLJ20033 2. 8 458997 AW937420 Hs. 69662 ESTs 2. 7 422864 AA318323 gb : EST20390 Retina II Homo sapiens cDNA 2. 7 430526 AF181862 Hs. 242407 G protein-coupled receptor, family C, gr 2. 7 452023 AB032999 Hs. 27566 KIAA1117 protein 27 432022 AL162042 Hs. 272348 Homo sapiens mRNA ; cDNA DKFZp761 L1212 (f 2. 7 452438 BE514230 Hs. 29595 JM4 protein 2. 7 435408 H07897 Hs. 4302 ESTs, Weakly similar to T29299 hypothe6 2. 7 418791 AA935633 Hs. 194628 ESTs 2. 7 438821 AA826425 Hs. 291829 ESTs 2. 7 423464 NM_016240 Hs. 128856 CSR1 protein 2. 7 442091 AW770493 Hs. 182874 guanine nucleotide binding protein (G pr 2. 7 442242 AV647908 Hs. 90424 Homo sapiens cDNA : FLJ23285 fis, clone H 2. 7 412436 AA665089 gb : nu76d01. s1 NCi_CGAP_Aiv1 Homosapiens 2. 7 432821 BE170702 Hs. 279005 solutecanierfamity21 (organicanion 2. 7 416404 AA180138 Hs. 107924 ESTs 2. 7 441364 AW450466 Hs. 126830 ESTs, Weakly similar to YD38_YEAST HYPOT 2. 7 450202 AW969756 Hs. 34145 ESTs, Weakly similar to B49647 GTP-bindi 2. 7 426304 AA374532 Hs. 124673 HomosapienscDNAFW11477fis, doneHE Z7 428722 U76456 Hs. 190787 tissue inhibitor of metalloproteinase 4 2. 7 449701 AW952323 Hs. 129908 K1AA0591 protein 2. 7 420372 AW960049 Hs. 293660 Homo sapiens, clone IMAGE : 3535476, mRNA, 2. 7 410318 AA084050 Hs. 269259 ESTs, Weakly similar to S23650 retroviru 2. 7 414603 R58394 Hs. 25119 ESTs, Weakly similar to YEXO_YEAST HYPOT 2. 7 416096 H18577 Hs. 88974 cytochrome b-245, beta polypeptide (chro 2. 7 420896 AW149342 Hs. 24444 Homo sapiens cDNA : FLJ22165 fis, clone H 2. 7 424856 AA347746 Hs. 9521 ESTs, Weakly similarto ZN43_HUMAN ZINC 2. 7 436304 AA339622 Hs. 108887 ESTs 2. 7 441027 Api911412 Hs. 126444 ESTs 2. 7 452545 N31940 Hs. 14434 ESTs, Weakly similar to 138022 hypothev 2. 7 454201 AB023191 Hs. 44131 KIAA0974 protein 2. 7 448560 BE613183 Hs. 23213 ESTs 2. 7 426807 AA385315 Hs. 156682 ESTs 27 425825 Api929508 Hs. 159590 lymphocyte antigen 6 complex, locus H 2. 7 440351 AF030933 Hs. 7179 RAD1 (S. pombe) homolog 2. 7 425390 A1092634 Hs. 156114 protein tyrosine phosphatase, non-recept 2. 7 427624 AA406245 Hs. 24895 ESTs 2. 7 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 2. 7 422491 AA338548 Hs. 117546 neuronatin 2. 7 424560 AA158727 Hs. 150555 protein predicted by clone 23733 2. 7 432415 T16971 Hs. 289014 ESTs, Weakly similar to A43932 mucin 2 p 2. 7 414865 AA157155 Hs. 274414 hypothetical protein FLJ 14457 2. 7 415827 H17462 Hs. 23079 ESTs 2. 7

445568 H00918 Hs. 268744 KIAA1796 protein 2. 7 433315 R96754 Hs. 239706 GRB2-associated binding protein 1 2. 7 428862 NM 000346 Hs. 2316 SRY (sex determining region Y)-box 9 (ca 2. 7 447959 A1452784 Hs. 270270 ESTs, Weakly similar to 2109260A B cell 2. 7 426420 BE383808 Hs. 322430 NDRG family, member 4 2. 7 436899 AA764852 Hs. 291567 ESTs 2. 7 444100 AA383343 Hs. 22116 CDC14 (cell division cycle 14, S. cerevi 27 426501 AW043782 Hs. 293616 ESTs 2. 7 449092 U91641 Hs. 22985 alpha2, 8-sialyltransferase 2. 7 427311 AB020672 Hs. 175411 KIAA0865 protein 2. 7 453313 BE005771 Hs. 153746 hypothetical protein FLJ22490 2. 7 404029 2. 7 416289 W26333 Hs. 337438 ESTs 2. 7 439108 AW163034'Hs. 6467 synapiogyrin 3 2. 6 418746 Api955289 Hs. 300759 ribosome protein L36 2. 6 412046 Y07847 Hs. 73088 RAS-related on chromsome 22 2. 6 435040 A1932350 Hs. 152825 ESTs 26 453083 U87223 Hs. 31622 contain associated protein 1 2. 6 428167 AA770021 Hs. 16332 ESTs 2. 6 420028 AB014680 Hs. 8786 carbohydrate (N-acetylglucosamine-6-0) s 2. 6 443715 Api583187 Hs. 9700 cyclin E1 2. 6 421247 BE391727 Hs. 102910 general transcripGonfactorIIH, polype 2. 6 424687 J05070 Hs. 151738 matrixmetalloproteinase9 (geia6naseB 2. 6 415056 AB004662 Hs. 77867 adenosine A1 receptor 2. 6 451697 AW449774 Hs. 296380 POM (POM121 rat homolog) and ZP3 fusion 2. 6 433701 AW445023 Hs. 15155 ESTs 2. 6 457358 Api479755 Hs. 129010 ESTs 2. 6 430347 NM_002039 Hs. 239706 GRB2-associated binding protein 1 2. 6 418027 AB037807 Hs. 83293 hypothetical protein 2. 6 440491 R35252 Hs. 24944 ESTs, Weakly similar to 2109260A B cell 2. 6 425171 AW732240 Hs. 16365 ESTs 26 459335 AW298545 Hs. 250726 EST 2. 6 425402 A1215881 Hs. 24970 ESTs, Weakly similar to B34323 GTP-bindi 2. 6 453169 AB037815 Hs. 32156 KIAA1394 protein 2. 6 433647 AA603367 Hs. 222294 ESTs 2. 6 450414 A1907735 Hs. 21446 KIAA1716 protein 2. 6 446233 A1282028 Hs. 25205 ESTs 2. 6 415446 F08898 Hs. 66075 ESTs 2. 6 445873 AA250970 Hs. 251946 poly (A)-binding protein, cytopiasmid-t 2. 6 413012 D83777 Hs. 75137 KIAA0193 gene product 2. 6 428671 BE297851 Hs. 189482 zinc finger protein 179 2. 6 427158 AA935603 Hs. 166231 ESTs 2. 6 408988 AL119844 Hs. 49476 Homo sapiens clone TUA8 Cri-du-chat regi 2. 6 459516 At049662 Hs. 246858 EST 2. 6 402693 2. 6 408039 AA131424 Hs. 50340 ESTs 2. 6 422896 AW961489 Hs. 154116 ESTs 2. 6 423130 AW897586 Hs. 21213 ESTs 2. 6 438796 W67821 Hs. 109590 genethonin 1 2. 6 439871 R88518 Hs. 46736 hypothetical protein FLJ23476 2. 6 440192 AA872282 Hs. 190596 ESTs 2. 6 419708 AK000753 Hs. 92374 hypothetical protein 2. 6 449436 AA860329 Hs. 279307 hypothetical protein DKFZp43412117 2. 6 436870 AW204219 Hs. 155560 calnexin 2. 6 448424 AW009892 Hs. 31924 ESTs 2. 6 401324 Z6 414136 AA812434 Hs. 119023 SMC2 (structural maintenance of chromoso 2. 6 433943 AA992805 Hs. 44865 lymphoid enhancer-binding factor 1 2. 6 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 2. 6 429139 F09092 Hs. 66087 ESTs 2. 6 423073 BE252922 Hs. 123119 MAD (mothers against decapentaplegic, Dr 2. 6 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 2. 6 444001 Ait95087 Hs. 152299 ESTs, Moderately similar to S65657 alpha 2. 6 412049 N53437 Hs. 18268 adenylate kinase 5 2. 6 441783 BE313412 Hs. 7961 Homo sapiens clone 25012 mRNA sequence 2. 6 425287 R88249 Hs. 155524 peanut (Drosophila)-like 2 2. 6 432149 AW614326 Hs. 157022 ESTS, Weakly similar to T34549 probable 2. 6 452234 AW084176 Hs. 223296 ESTs, Weakiy similar to 138022 hypotheti 2. 6 453478 AF083898 Hs. 33021 neuro-oncologicai ventral antigen 2 2. 6 418962 AA714835 Hs. 271863 ESTs 2. 6 418858 AW961605 Hs. 21145 hypothetical protein RG083M05. 2 2. 6 443257 Ai334040 Hs. 11614 HSPC065 protein 2. 6 428748 AW593206 Hs. 98785 Ksp37 protein 2. 6 444984 H15474 Hs. 132898 fatty acid desaturase 1 2. 6 433404 T32982 Hs. 102720 ESTs 2. 6 434779 AF153815 Hs. 50151 potassium inwardly-rectifying channel, s 2. 6 420582 BE047878 Hs. 99093 Homo sapiens chromosome 19, cosmid R2837 2. 6 452856 AF034799 Hs. 30881 protein tyrosine phosphatase, receptor t 2. 6 436440 Api471862 Hs. 196008 Homo sapiens cDNA FLJ11723 fis, clone HE 2. 6 438527 A1969251 Hs. 115325 RAB7 member RAS oncogene family-like 1 2. 6 433216 AF217412 Hs. 47320 neuroligin 3 2. 6 435380 AA679001 Hs. 192221 ESTs 2. 6 428966 AF059214 Hs. 194687 cholesterol 25-hydroxylase 2. 6

439653 AW021103 Hs. 6631 hypothetical protein FU20373 Z6 419304 Api271326 Hs. 146101 ESTs, Weakly similar to T45070 protein k 2. 6 422991 H10940 Hs. 48965 Homo sapiens cDNA : FLJ21693 fis, clone C 2. 6 448548 R13209 Hs. 21413 solutecarrierfamDy12, (potassium-chi 2. 6 435370 A1964074 Hs. 225838 ESTs 2. 6 408875 NM015434 Hs. 48604 DKFZP434B168 protein 2. 5 457005 AJ007421 Hs. 172597 sal (Drosophila)-like 3 2. 5 430154 AW583058 Hs. 234726 serine (orcysteine) proteinase inhibito 2. 5 438549 BE386801 Hs. 21858 Mnucteotide repeat containing 3 2. 5 427951 A1826125 Hs. 43546 ESTs 2. 5 411800 N39342 Hs. 103042 microtubuie-associated protein 1B 2. 5 457683 Al821877 Hs. 140002 ESTs, Moderately similar to ALU7 HUMAN A 2. 5 451422 AB002336 Hs. 26395 erythrocyte membrane protein band 4. 1-li 2. 5 430713 AA351647 Hs. 2642 eukaryotic translation elongation factor 2. 5 428826 AL048842 Hs. 194019 attraction 2. 5 428963 AW382682 Hs. 258208 Homo sapiens, clone MGC : 15606, mRNA, com 25 428141 D50402 Hs. 182611 solute carrier family 11 (proton-coupled 2. 5 429550 AW293055 Hs. 119357 ESTs 2. 5 438662 AA223599 Hs. 6351 cleavage and polyadenylaGon specific fa 2. 5 435760 AF231922 Hs. 213004 chromosome 21 open reading frame 62 2. 5 427513 Ai476318 Hs. 192480 ESTs 2. 5 430061 AB037817 Hs. 230188 KIAA1396 protein 2. 5 435923 BE301930 Hs. 5010 Homo sapiens clone 24672 mRNA sequence 2. 5 417123 BE326521 Hs. 159450 ESTs 2. 5 439699 AF086534 Hs. 187561 ESTs, Moderately similar to AWL-HUMAN A 2. 5 412980 A1815750 Hs. 20977 hypothetical protein MGC3129 similar to 2. 5 427209 H06509 Hs. 92423 KIAA1566 protein 2. 5 424327 AA431707 Hs. 31209 ESTs 2. 5 436340 R42246 Hs. 21606 ESTs 2. 5 450650 T65617 Hs. 101257 hypothetical protein MGC3295 2. 5 439444 AI277652 Hs. 54578 ESTs, Weakly similar to 138022 hypothefi 2. 5 400777 2. 5 439478 AF049460 Hs. 6574 deformed epidermal autoregulatory factor 2. 5 450407 NM000810 Hs. 24969 gamma-aminobutydc acid (GABA) A recepto 2. 5 450385 Al631024 Hs. 24948 synuclein, alpha interacting protein (sy 2. 5 432558 R97268 Hs. 177269 ESTs 2. 5 400860 2. 5 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-2. 5 416063 BE047699 Hs. 93454 ESTs 2. 5 414998 NM002543 Hs. 77729 oxidised low density lipoprotein (pectin 2. 5 452823 AB012124 Hs. 30696 transcription factor-like 5 (basic helix 2. 5 417791 AW965339 Hs. 111471 ESTs 2. 5 418079 R40058 Hs. 6911 ESTs 2. 5 408495 W68796 Hs. 237731 ESTs 2. 5 442104 L20971 Hs. 188 phosphodiesterase 4B, cAMP-specific (dun Z5 437370 AL359567 Hs. 161962 Homo sapiens mRNA ; cDNA DKFZp547D023 (fr 2. 5 429803 W81489 Hs. 223025 RAB31, memberRASoncogenefamily 2. 5 424959 NM 005781 Hs. 153937 activated p21cdc42Hs kinase 2. 5 427413 BE547647 Hs. 177781 hypothetical protein MGC5618 2. 5 408955 BE315170 Hs. 8087 NAG-5 protein 2. 5 415261 T40928 Hs. 8346 ESTs 2. 5 415716 N59294 Hs. 179662 nucleosome assembly protein 1-like 1 2. 5 417873 BE266659 Hs. 293659 Homosapiens, SimilartoRIKENcDNAM30 2. 5 418388 R72332 Hs. 29258 Homo sapiens CDNA FLJL 1364 fis, clone HE 2. 5 421002 AF116030 Hs. 100932 transcription factor 17 2. 5 423244 AL039379 Hs. 209602 ESTs, Weakly similar to ubiquitous TPR m 2. 5 423553 AA405635 Hs. 96854 ESTs, Weakly simiiar to DYLX_HUMAN CYTOP 2. 5 427961 AW293165 Hs. 143134 ESTs 2. 5 428301 AW628666 Hs. 98440 ESTs, Weakly similar to 138022 hypothe6 2. 5 428508 BE252383 Hs. 184668 SBB131 protein 2. 5 428858 AA436760 gb : zv67d11. r1 SoarestotaifetusNb2HF8 2. 5 428943 AW086180 Hs. 37636 ESTs, Weakly similar to KIAA1392 protein 2. 5 432427 AL037630 Hs. 6638 Homo sapiens cDNA FLJ 11602 fis, clone HE 2. 5 435347 AW014873 Hs. 116963 ESTs 2. 5 437949 U78519 Hs. 41654 ESTs, Weakly similar to A46010 X-linked 2. 5 438208 AL041224 Hs. 65379 ESTs 2. 5 440286 U29589 Hs. 7138 cholinergic receptor, muscadnic 3 2. 5 441523 AW514263 Hs. 301771 ESTs, Weakly similar to ALUF HUMAN ! ! ! ! 2. 5 441805 AA285136 Hs. 301914 neuronai specific transcription factor D 2. 5 442337 Api371029 Hs. 129257 ESTs, Weakly similar to TC17 HUMAN TRANS 2. 5 442789 AW904361 Hs. 131191 ESTs, Weakly similar to ALU7 HUMAN ALU S 2. 5 445556 A1910241 Hs. 12887 actin-related protein 3-beta 2. 5 449086 A1628357 Hs. 208037 ESTs 2. 5 459583 Api907673 gb : L-BT152-080399-004BT152Homosapien Z5 TABLE 8B : Pkey : Unique Eos probeset identfier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408432 1058667_1 AW195262R27868AW811262 412225 1284108_1 AW902042 N77591

412436 129439 1 AA665089 AA135130 AA484059 AA102419 AW877765 416120 1571266 1 H46739 H51513 H19779 416871 1626761 1 H98716 N90792 N24283 416913 1630011 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AAi 90449 AW513465 BE161006 BE162499 422864 222336 1 AA318323 H 11145 R15289 AA451945 AA476690 AA436954 Z43802 F11753 T65491 D81821 422949 223184_1 M319435 N56456 AA319377 AW961532 T48452 AA894424 422977 223410_1 AA631498 A1017191 AA491211 AA761823 AA714555 AA768099 AA808286 AI934069 AA570223 AA574389 AA582438 AI745346 AW964510 AA319642 AW853758 H56414 423756 231725J AA828125AA834883AA330555 425168 2475521 R96366 AL133929 AA351636 H78818 AA477084 Z28957 H80194 425517 252729_1 AF121179BE162736M358827 426413 266650 1 AA377823 AW954494 A1022688 428002 2856021 AA418703 AA418711 BE071915 BE071920 BE071912 428679 294049 1 M431765M432015 428858 2964331 AA436760 AW237453 BE327496 N47347 N56967 429007 298301 1 D80642 AA443145 AL119015 AW904500 429163 300543J AA884766AW974271AA592975AA447312 433532 368950_1 AW975367 M598607 M742735 436190 41555_1 AK001059M633055 437034 4317131 AA742643AA808575AW976668 438458 457837_1 AW975186 AA807807 D29548 438993 467651 1 AA828995 AA834879 A1926361 439566 47387_1 AF086387W77884W72711 440322 4919661 AA879430 BE070262 BE070493 BE070272 BE070484 BE070397 BE070395 BE070201 BE070198 BE070404 BE070270 BE070400 444584 611496_1 Ai168422D80113T59074 447197 711623 1 R36075 A1366546 R36167 448451 764066_1 AW015994 R39898 AW000978 AiS98202 Al521706 450625 84032_1 AW970107M513951 M010406 452453 918300 Ai902519 Ai902518 AI902516 454996 1248640_1 AW850180 AW850326 455350 1283853_1 AW901809 AW901787 AW901795 AW901792 AW901744 AW901753 AW901807 AW901798 TABLE 8C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (Gi) numbers."Dunham, et al."refers to the publication entitled'The DNA sequence of human chromosome 2Z Dunham, et aL (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. NLposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 400777 8131663 Plus 70745-71121 400780 8131663 Minus 118372-118619 400859 9757499 Minus 91888-92018, 98131-98294, 99474-99570 400860 9757499 Minus 151830-152104, 152649-152744 400992 8096828 Plus 140390-140822 401324 9863791 Plus 234057-234174 402408 9796239 Minus 110326-110491 402604 9909420 Plus 20393-20767 402605 9909420 Minus 47680-47973 402693 8569863 Minus 82366-82515 402855 9662953 Minus 59763-59909 404029 7671252 Plus 108716-111112 404048 3688074 Minus 54421-56808 404049 3688074 Minus 75765-78155 404283 2276311 Minus 99460-99564 404299 5738652 Minus 3826-4025 404541 8318559 Plus 103456-103664 404584 9857511 Plus 138651-139153 404593 9944086 Minus 74922-75788 404721 9856648 Minus 173763-174294 404819 4678240 Plus 16223-16319, 16427-16513, 16736-16859, 16941-17075, 17170-17287, 17389-17529, 18261-18357, 18443-18578 405238 7249119 Minus 51728-51836 405771 7018349 Plus 91191-91254, 91510-91589 405819 4007557 Plus 2830-2967 406311 9211559 Minus 137114-139033 TABLE 9A : ABOUT 1202 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CENTRAL NERVOUS SYSTEM (CNS) Table 9A lists about 1202 genes up-regulated in glioblastoma compared to normal adult central nervous system (CNS). These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average* giioMastoma to'average* normai aduit CNS tissues was greater than or equal to 2. 0. The'average* gliobiastoma level was set to the 75th percent amongst various glioblastoma tumors. The"average"normal adult CNS tissue level was set to the 95th percentile amongst various non-malignant tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10th percenGle value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigeneiD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of 75th percent tumor to 95th percentile normal adult nervous system tissue Pkey ExAccn UnigenelD Unigene Title R1 452461 N78223 Hs. 108106 transcription factor 20. 1 436895 AF037335 Hs. 5338 carbonic anhydrase XII 15. 2 453941 U39817 Hs. 36820'Bloom syndrome 14. 2

443247 BE614387 Hs. 333893 c-MyctargetJP01 12. 4 428330 L22524 Hs. 2256 matrix metalloproteinase 7 (matrilysin, 12. 0 447342 AI199268 Hs. 19322 Homo sapiens, Similar to RIKEN cDNA 2010 11. 7 422163 AF027208 Hs. 112360 prominin (mouse)-like 1 11. 4 439451 AF086270 Hs. 278554 heterochromatin-like protein 1 11. 2 424800 AL035588 Hs. 153203 MyoD family inhibitor 10. 2 416111 AA033813 Hs. 79018 chroma6nassembly1actor1, subunitA (10. 0 444190 A1878918 Hs. 10526 cysteine and glycine-rich protein 2 9. 9 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 9. 9 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 9. 8 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 9. 4 439978 BE139460 Hs. 124673 Homo sapiens cDNA FLJ11477 fis, clone HE 8. 9 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIM1330 protein 8. 9 456516 BE172704 Hs. 222746 KIAA1610 protein 8. 2 420092 AA814043 Hs. 88045 ESTs 7. 9 422631 BE218919 Hs. 118793 hypothetical protein FUI0688 7. 9 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 7. 9 438527 A1969251 Hs. 115325 RAB7, member RAS oncosqene famity-6ke 1 7. 9 427581 NM014788 Hs. 179703 KlM01Z9geneproduct 7. 8 418661 NM 001949 Hs. 1189 E2Ftranscriptionfactor3. 7. 8 440684 Ai253123 Hs. 127356 ESTs, Highly similar to S21424 nesting 7. 8 429643 AA455889 Hs. 167279 FYVE-finger-containing RabS effector pro 7. 7 409638 AW450420 Hs. 21335 ESTs 7. 5 444665 BE613126 Hs. 47783 B aggressive lymphoma gene 7. 5 456759 BE259150 Hs. 127792 delta (Drosophila)-like 3 7. 5 412777 A1335773 Hs. 270123 ESTs 7. 4 436607 AW661783 Hs. 211061 ESTs 7. 3 432058 AW665996 Hs. 130729 ESTs, Weakly similar to ALU1HUMANALUS 7. 3 417061 Ai675944 Hs. 188691 Homo sapiens cDNA FLJ12033 fis, clone HE 7. 3 428976 AL037824 Hs. 194695 ras homolog gene family, member 1 7. 2 433244 AB040943 Hs. 271285 KA1510 protein 7. 1 436726 AA324975 Hs. 128993 ESTs, Weakly similar to T00079 hypotheti 7. 1 408432 AW195262 gb : xn67b05. x1NCiCGAPCML1 Homo sapiens 7. 1 434164 AW207019 Hs. 148135 serine/threoninekinase33 7. 0 445873 AA250970 Hs. 251946 poly (A)-binding protein, cytopiasmid-t 7. 0 439726 AW449893 Hs. 293707 ESTs, Weakly similar to 138598 zinc fing 7. 0 432656 NM 000246 Hs. 3076 MHC class li transac6vator 6. 8 431117 AF003522 Hs. 250500 delta (Drosophila)-like 1 6. 8 453387 A1990741 Hs. 252809 ESTs 6. 8 418821 AA436002 Hs. 183161 ESTs 6. 6 437034 AA742643 gb : ny91c01. s1 NCI_CGAP_GCB1 Homosapiens 6. 6 411252 AB018549 Hs. 69328 MD-2 protein 6. 5 424687 J05070 Hs. 151738 matrixmetalloproteinase9 (gela6nsseB 6. 4 452953 AI932884 Hs. 271741 ESTs, Weakly similar to A46010 X-linked 6. 3 433532 AW975367 gb : EST387475 MAGE resequences, MAGN Homo 6. 3 420311 AW445044 Hs. 38207 Human DNA sequence from clone RP4-530115 6. 3 418097 R45137 Hs. 21868 ESTs 6. 2 407304 AA565832 gb : nj32bO3. s1 NCI CGAP_AA1 Homo sapiens 6. 2 435256 AF193766 Hs. 13872 cytokine-like protein C17 6. 1 449448 D60730 Hs. 57471 ESTs 6. 1 403790 6. 0 425517 AF121179 gb : AF121179 Homo sapiens liver (Chang L-6. 0 420674 NM 000055 Hs. 1327 butyrylcholinesterase 6. 0 435542 AA687376 Hs. 269533 ESTs 5. 9 418216 AA662240 Hs. 283099 AF15q14 protein 5. 8 439086 AF085947 gb : Homo sapiens full length insert cDNA 5. 8 408037 AW271720 Hs. 42233 hypothetical protein FLJ10300 5. 7 412225 AW902042 gb : QVO-NN1022-170400-193-c02NN1022Homo 5. 7 436109 AA922153 Hs. 132760 hypothetical protein MGC15729 5. 7 435005 U80743 Hs. 306094 Mnudeotide repeat containing 12 5. 7 429149 AW193360 Hs. 197962 ESTs, Weakly similar to 138022 hypothe6 5. 7 418113 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 5. 6 405558 5. 6 442432 BE093589 Hs. 38178 hypothetical protein FLJ23468 5. 6 442547 AA306997 Hs. 217484 ESTs, Weakly similar to AW1_HUMAN AW S 5. 6 413063 AL035737 Hs. 75184 chitinase 3-like1 (cartilage glycoprote 5. 5 420560 AW207748 Hs. 59115 ESTs 5. 5 408096 BE250162 Hs. 83765 dihydrofolatereduclase 5. 5 443539 A1076182 Hs. 134074 ESTs, Moderately similar to ALU6 HUMAN A 5. 4 426318 AA375125 Hs. 147112 HomosapienscDNA : FLJ22322 fis, clone H 5. 4 429115 AA446728 Hs. 289020 Homo sapiens cDNA FLJ14098 fis, clone MA 5. 3 453900 AW003582 Hs. 226414 ESTs, Weakly similar to ALU8 HUMAN ALU S 5. 3 444168 AW379879 gb : RC1-HT0256-081199-011-f01HT0256Homo 5. 3 432789 D26361 Hs. 3104 KIAA0042 gene product 5. 3 437036 A1571514 Hs. 133022 ESTs 5. 2 421247 BE391727 Hs. 102910 general transcription factor IIH, polype 5. 2 441523 AW514263 Hs. 301771 ESTs, Weakiy simitar to ALUFHUMAN ! ! ! ! 5. 2 451106 BE382701 Hs. 25960 v-myc avian myelocytomatosis viral relat 5. 1 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 5. 1 454157 AW162906 Hs. 312481 ESTs, Weakly similar to S66668 hydrogen 5. 1 423343 AA324643 Hs. 246106 ESTs 5. 1 425292 NM_005824 Hs. 155545 37 kDa leucine-dch repeat (LRR) protein 5. 1 406679 AA070786 gb : zm66bO7. rl Stratagene neuroepithelium 5. 1

442671 A1005668 Hs. 134779 EST 5. 1 433001 AF217513 Hs. 279905 clone HQ0310 PR00310p1 5. 0 418819 AA228776 Hs. 191721 ESTs 5. 0 432946 U60899 Hs. 279854 mannosidase, alpha, ciass 2B, member 1 4. 9 420730 NM 002691 Hs. 99890 polymerase (DNA directed), delta 1, cata 4. 9 441217 Ai922183 Hs. 213246 ESTs 4. 9 453385 AW296101 Hs. 252806 ESTs 4. 8 418203 X54942 Hs. 83758 CDC28 protein kinase 2 4. 7 450813 A1739625 Hs. 203376 ESTs 4. 7 444006 BE395085 Hs. 10086 type I transmembrane protein Fn14 4. 7 412530 AA766268 Hs. 266273 hypotheticalprotein FU13346 4. 7 431070 AW408164 Hs. 249184 transcription factor 19 (SCI) 4. 7 429786 AL080232 Hs. 220696 Homo sapiens mRNA ; cDNA DKFZp586A061 (fr 4. 7 405771 4. 6 457065 A1476318 Hs. 192480 ESTs 4. 6 436190 AK001059 gb : Homo sapiens cDNA FW101 97 fis, Cone 4. 6 400859 4. 6 435267 N23797 Hs. 110114 ESTs 4. 6 443454 AM57494 Hs. 133421 ESTs 4. 5 452811 AA937079 Hs. 118983 hypothe6calprotein FLJ12150 4. 5 437267 AW511443 Hs. 258110 ESTs 4. 5 435020 AW505076 Hs. 301855 DiGeorge syndrome critical region gene 8 4. 5 454269 Ai961060 Hs. 129908 KIAA0591 protein 4. 5 422106 D84239 Hs. 111732 Fcfragment oflgGbinding protein 4. 5 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur 4. 5 456534 X91195 Hs. 100623 phospholipase C, beta 3, neighbor pseudo 4. 5 423756 AA828125 gb : od71aO9. s1 NCl_CGAP_Ov2 Homo sapiens 4. 5 417308 H60720 Hs. 81892 KIAA0101 gene product 4. 5 422170 A1791949 Hs. 112432 an6-Mullerian hormone 4. 4 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytoiac6n) 4. 4 406568 AF088886 Hs. 11590 cathepsin F 4, 4 426812 AF105365 Hs. 172613 solute carrier family 12 (potassium/chlo 4. 4 402516 4. 4 432865 A1753709 Hs. 152484 ESTs, Weakly similar to 138022 hypothet 4. 4 413625 AW451103 Hs. 71371 ESTs 4. 4 436098 R20597 Hs. 9739 glycerol-3-phosphate dehydrogenase 1 (so 4. 4 418333 W92113 gb : zh48eO1. r1 Soares fetal liver_spleen 4. 4 416933 BE561850 Hs. 80506 smatlnuclearribonucleoproteinpolypept 4, 4 438192 A1859065 Hs. 337620 Homo sapiens AFG3L1 isoform 1 MRNA, pad 4. 3 457374 AA493662 gb : nhO5d12. s1 NCI CGAP Thy1 Homo sapiens 4. 3 433159 AB035898 Hs. 150587 kinesin-like protein 2 4. 3 444386 BE065183 gb : RC1-BT0314-020200-012-c04 BT0314 Homo 4. 3 453202 AW085781 Hs. 26270 hypothetical protein FLJ 11588 4. 3 441020 W79283 Hs. 35962 ESTs 4. 3 414733 BE514535 Hs. 77171 minichromosome maintenance deficient (S. 4. 3 407902 AL117474 Hs. 41181 HomosapiensmRNA ; cDNADKFZp727C191 (fr 4. 3 405701 4. 3 451659 BE379761 Hs. 14248 ESTs 4. 3 418845 AA852985 Hs. 89232 chromobox homolog 5 (Drosophila HP1 alph 4. 2 433323 AA805132 Hs. 30701 ESTs 4. 2 439811 AA135332 Hs. 71608 ESTs 4. 2 415406 T26510 gb : AB282F8R Infant brain, LLNL array of 4. 2 436282 R91913 Hs. 272104 ESTs, ModeratelysimilartoALU1 HUMANA 4. 1 441269 AW015206 Hs. 178784 ESTs 4. 1 418727 AA227609 Hs. 94834 ESTs 4. 1 433006 BE242758 Hs. 190223 ESTs, Moderately similar to T29285 hypot 4. 1 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel 4. 1 430786 AA486144 Hs. 31293 ESTs 4. 1 445372 N36417 Hs. 144928 ESTs 4. 1 410555 U92649 Hs. 64311 adisintegnnandmetatfoproteinasedoma 4. 0 457465 AW301344 Hs. 122908 DNA replication factor 4. 0 422094 AF129535 Hs. 272027 F-box only protein 5 4. 0 442029 AW956698 Hs. 14456 neural precursor cell expressed, develop 4. 0 459321 AW044477 Hs. 299538 ESTs 4. 0 421308 AA687322 Hs. 192843 leucine zipper protein FKSG14 4. 0 420567 AK000812 Hs. 98874 similar to proline-rich protein 48 4. 0 447004 AW296968 Hs. 157539 ESTs 4. 0 448295 Ai381911 Hs. 334859 KIAAL 814 protein 3. 9 439699 AF086534 Hs. 187561 ESTs, Moderately similar to ALU1 HUMAN A 3. 9 440704 M69241 Hs. 162 insulin-like growth factor binding prote 3. 9 453096 AW294631 Hs. 11325 ESTs 3. 9 457026 AA397620 Hs. 48692 ESTs 3. 9 404642 3. 9 450375 AA009647 Hs. 8850 a disintegrin and metatloproteinase doma 3. 9 430132 AA204686 Hs. 234149 hypothetical protein FLJ20647 3. 9 437718 Ai927288 Hs. 196779 ESTs 3. 9 438490 AW593272 Hs. 301299 ESTs 3. 9 429919 AA460692 Hs. 278945 hypotheticaiprotein FLJ23024 3. 9 413604 R51767 gb : yg73911. r1Soaresinfanibrain1NIBH 3. 9 425599 AW366745 Hs. 214140 ESTs, Weakly similar to ALU 1 _HUMAN ALU S 3. 9 448796 AA147829 Hs. 301431 endothelial zinc finger protein induced 3. 9 449300 Api656959 Hs. 222165 ESTs 3. 8 452203 X57522 Hs. 158164 fransporter 1, ATP-binding cassette, sub 3. 8

425769 U72513 Hs. 159486 Human RPL13-2pseudogenemRNA, compiete 3. 8 404295 3. 8 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-3. 8 428728 NM016625 Hs. 191381 hypothetical protein 3. 8 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 3. 8 430172 AA468591 Hs. 161889 ESTs 3. 8 447499 AW262580 Hs. 147674 protocadherin beta 16 3. 8 405884 3. 8 437236 AW137817 Hs. 244353 ESTs 3. 7 418883 BE387036 Hs. 1211 acid phosphatase 5, tartrate resistant 3. 7 444143 AW747996 Hs. 160999 ESTs, Moderately similar to A56194 throm 3. 7 425529 NM_014656 Hs. 158282 KIAA0040 gene product 3. 7 425502 R98895 Hs. 125823 ESTs 3. 7 419741 Nom007019 Hs. 93002 ubiqui6ncarrierproteinE2-C 3. 7 402424 3. 7 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxylating ; 3. 7 434072 H70854 Hs. 283059 Homo sapiens PR01082 mRNA, complete cds 3. 7 414872 U82010 Hs. 77513 COX10 (yeast) homolog, cytochrome c oxid 3. 7 426071 AW138057 Hs. 163835 ESTs 3. 7 419078 M93119 Hs. 89584 insulinoma-associated 1 3. 7 428037 N47474 Hs. 89230 potassium intermediate/small conductance 3. 7 416547 H62914 Hs. 268946 ESTs, Weakly similar to PG4259 fenifin 3. 7 436899 AA764852 Hs. 291567 ESTs 3. 6 436722 AW975977 gb : EST388086 MAGE resequences, MAGN Homo 3. 6 440652 A1216751 Hs. 143977 ESTs 3. 6 428450 NM_014791 Hs. 184339 KIAA0175 gene product 3. 6 452103 R42764 Hs. 339654 ESTs, Weakly similar to 138022 hypotheo 3. 6 409048 H59990 Hs. 37699 ESTs 3. 6 439546 AF088056 gb : Homo sapiens full length insert cDNA 3. 6 443544 A W6315 Hs. 16359 ESTs 3. 6 418478 U38945 Hs. 1174 cyclin-dependent kinase inhibitor 2A (me 3. 6 435889 A1249107 Hs. 269901 ESTs 3. 6 420301 AA767526 Hs. 22030 paired box gene 5 (B-cell lineage specif 3. 6 438078 A1016377 Hs. 131693 ESTs 3. 6 408420 NM 006915 Hs. 44766 retinitis pigmentosa 2 (X-linked recessi 3. 6 416871 H98716 gb : yx13dO8. s1 Soares melanocyte 2NbHM Ho 3. 5 424085 NM002914 Hs. 139226 replication factor C (activator 1) 2 (40 3. 5 446291 BE397753 Hs. 14623 interferon, gamma-inducible protein 30 3. 5 432281 AK001239 Hs. 274263 hypotheticaiprotein FLJ10377 3. 5 436123 AA057484 Hs. 35406 ESTs, Highly similar to unnamed protein 3. 5 411256 AW834039 gb : QVO-TT0010-091199-053-e09TT0010Homo 3. 5 419239 AA468183 Hs. 184598 Homo sapiens cDNA : FLJ23241 fis, clone C 3. 5 435065 BE064391 gb : RC4-BT0310-110300-015-bO8BT0310Homo 3. 5 435532 AW291488 Hs. 117305 Homo sapiens, clone IMAGE : 3682908, mRNA 3. 5 447101 N72185 Hs. 44189 ESTs 3. 5 410530 M25809 Hs. 64173 ATPase, H+ transporting, lysosomal (vacu 3. 5 422156 N34524 gb : yyS6d10. s1 Soares_muitple_scierosis_ 3. 5 453616 NM 003462 Hs. 33846 dynein, axonemal, light intermediate pol 3. 5 439743 AL389956 Hs. 283858 Homo sapiens mRNA full length insert cDN 3. 5 453884 AA355925 Hs. 36232 KIAA0186 gene product 3. 5 424954 NM_000546 Hs. 1846 tumor protein p53 (Li-Fraumeni syndrome) 3. 5 420721 AA927802 Hs. 159471 ZAP3 protein 3. 5 426764 AA732524 Hs. 151464 ESTs, WeaklysimilartoALUC HUMANiii ! 3. 4 420649 AI866964 Hs. 124704 ESTs, Moderately similar to S65657 alpha 3. 4 448831 AL080123 Hs. 22182 zinc finger protein 23 (KOX 16) 3. 4 444371 BE540274 Hs. 239 forkhead box M1 3. 4 402604 3. 4 442407 AW469584 Hs. 32353 mitogen-acbvated protein kinase kinase 3. 4 414300 Ai304870 Hs. 188680 ESTs 3. 4 444670 H58373 Hs. 332938 hypothetical protein MGC5370 3. 4 414550 BE379808 gb : 601159567T1 NlH_MGC_53Homosapiensc 3. 4 452211 A1985513 Hs. 233420 ESTs 3. 4 414416 AW409985 Hs. 76084 hypothetical protein MGC2721 3. 4 449961 AW265634 Hs. 133100 ESTs 3. 4 413257 BE075035 gb : PM3-BT0584-260300-002-gO5 BT0584 Homo 3. 4 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 3. 4 417404 NM 007350 Hs. 82101 pleckstrin homology-like domain, family 3. 4 422846 BE513934 Hs. 1583 neutrophil cytosolic factor 1 (47kD, chr 3. 4 446189 H85224 Hs. 214013 ESTs 3. 4 437385 AA757055 Hs. 164060 ESTs 3. 4 453652 AW009640 Hs. 28368 ESTs, Moderately similar to S65657 alpha 3. 4 408298 Api745325 Hs. 271923 Homo sapiens cDNA : FU22785 fis, clone K 3. 4 455778 BE088746 gb : CM2-BT0693-210300-123-d09 BT0693 Homo 3. 3 417546 H65569 Hs. 18845 ESTs 3. 3 412471 M63193 Hs. 73946 endothelial cell growth factor I (platel 3. 3 454631 AW811324 gb : IL3-ST0141-131099-017-A02ST0141 Homo 3. 3 454294 AB000734 Hs. 50640 JAK binding protein 3. 3 457131 AC002310 Hs. 301463 Human Chromosome 16 BAC clone CIT987SK-A 3. 3 410102 AW248508 Hs. 279727 Homo sapiens cDNA FLJ14035 fis, clone HE 3. 3 449676 AW380579 Hs. 209657 ESTs 3. 3 436211 AK001581 Hs. 334828 hypothetical protein FLJ10719 ; KIAA1794 3. 3 453746 AL120611 gb : DKFZp761H119r1761 (synonym : hamy2) 3. 3 452799 Ai948829 Hs. 213786 ESTs 3. 3

435380 AA679001 Hs. 192221 ESTs 3. 3 426746 J03626 Hs. 2057 uridine monophosphate synthetase (orotat 3. 3 453362 H14988 Hs. 107375 ESTs 3. 3 456473 Ai202788 Hs. 25682 Homo sapiens mRNA for KIAA1863 protein, 3. 3 416426 AA180256 Hs. 210473 Homo sapiens cDNA FW14872 fis, Cone PL 3. 3 445777 A1580371 Hs. 145384 ESTs 3. 3 423757 AL049337 Hs. 132571 Homo sapiens mRNA ; cDNA DKFZp564P016 (fr 3. 3 431941 AK000106 Hs. 272227 Homo sapiens DNA FLJ20099 fis, clone CO 3. 3 404299 3. 3 404108 3. 3 425189 H16622 gb : ym26cO7. r1 Soares infantbrain 1NIB H 3. 3 449318 AW236021 Hs. 78531 Homo sapiens, Similar to RIKEN cDNA 5730 3. 3 450193 A1916071 Hs. 15607 Homo sapiens Fanconi anemia complementat 3. 2 427725 U66839 Hs. 180533 mitogen-activated protein kinase kinase 3. 2 424051 AL110203 Hs. 138411 HomosapiensmRNA ; cDNA DKFZp586J1922 (f 3. 2 418968 NM000078 Hs. 89538 cholesteryl ester transfer protein, plas 3. 2 449248 M33782 Hs. 23391 Homo sapiens, Similar to transcription f 3. 2 439416 W58294 Hs. 56254 ESTs 3. 2 401596 AA172106 Hs. 110950 Rag C protein 3. 2 408380 AF123050 Hs. 44532 diubiquitin 3. 2 450325 AI935962 Hs. 26289 ESTs 3. 2 428730 AA625947 Hs. 25750 ESTs 3. 2 457536 AA305233 Hs. 278712 eukaryotic translation initiation factor 3. 2 426836 N41720 Hs. 172684 vesicle-associated membrane protein 8 (e 3. 2 442710 A1015631 Hs. 23210 ESTs 3. 2 435232 NM_001262 Hs. 4854 cyclin-dependent kinase inhibitor 2C (pl 3. 2 430970 A1018210 Hs. 144083 ESTs 3. 2 416192 NM 005036 Hs. 998 peroxisome proliferative ac6vated recep 3. 2 446676 H09380 Hs. 300965 ESTs 3. 2 451459 AI797515 Hs. 270560 ESTs, Moderately similar to ALU7 HUMAN A 3. 2 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, 3. 2 413840 Ai301558 Hs. 146381 RNA binding motif protein, X chromosome 3. 2 448751 BE551203 Hs. 201792 ESTs 3. 2 432593 AW301003 Hs. 51483 ESTs, Weakly similar to hypothetical pro 3. 2 458786 A1457098 Hs. 280848 ESTs 3. 2 455909 BE156417 Hs. 278798 ESTs 3. 2 419311 AA689591 gb : nv66a12. s1 NCLCGAP_GCB1 Homosapiens 3. 2 439710 AF086543 gb : Homo sapiens full length insert cDNA 3. 2 434559 AF147315 gb : HomosapiensfulliengthinsertcDNA 3. 1 455800 R22479 Hs. 167073 Homo sapiens cDNA FLJ13047 fis, clone NT 3. 1 436703 AW880614 Hs. 146381 RNA binding motif protein, X chromosome 3. 1 414799 Ai752416 Hs. 77326 insulin-like growth factor binding prote 3. 1 437860 AA333063 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 3. 1 434182 W20309 Hs. 118520 G-protein gamma-12 subunit 3. 1 417900 BE250127 Hs. 82906 CDC20 (cell division cycle 20, S. cerevi 3. 1 434769 AA648884 Hs. 134278 Homo sapiens cDNA FU12676 fis, clone NT 3. 1 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 3. 1 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 3. 1 447959 A1452784 Hs. 270270 ESTs, Weakly similar to 2109260A B cell 3. 1 404589 3. 1 421764 A1681535 Hs. 148135 serine/threonine kinase 33 3. 1 419986 A1345455 Hs. 78915 GA-binding protein transcription factor, 3. 1 416941 BE000150 Hs. 48778 niban protein 3. 1 414761 AU077228 Hs. 77256 enhancer ofzeste (Drosophila) homolog 2 3. 1 449611 A1970394 Hs. 197075 ESTs 3. 1 434746 AA648368 Hs. 295368 ESTs 3. 1 434274 AA628539 Hs. 116252 ESTs, ModeraielysimDartoALU1_HUMANA 3. 1 427899 AA829286 Hs. 332053 serum amyloid A1 3. 1 417642 BE302665 Hs. 105461 hypothetical protein FLJ20357 3. 1 452472 AW957300 Hs. 294142 ESTs, Weakly similar to C55663 oligodend 3. 1 446131 NM 000929 Hs. 290 phospholipase A2, group V 3. 1 440052 Ai633744 Hs. 195648 ESTs, Weakly similar to 138022 hypotheti 3. 1 426531 AA381071 gb : EST94100 Activated T-cells Xil Homo s 3. 1 422158 L10343 Hs. 112341 protease inhibitor 3, skin-derived (SKAL 3. 1 406267 3. 1 447039 AV661798 Hs. 282915 ESTs 3. 1 404802 3. 1 406927 M26460 gb : Homo sapiens (clone 104) retinoblasto 3. 1 419314 AW971924 Hs. 87280 ESTs 3. 0 435894 A1076667 Hs. 188011 ESTs 3. 0 432140 AK000404 Hs. 272688 hypothetical protein FLJ20397 3. 0 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 3. 0 425202 AW962282 Hs. 152049 ESTs, Weakly similar to 138022 hypotheb 3. 0 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 3. 0 418241 M26682 Hs. 1149 L ! Mdomainonly1 (rhombo6n1) 3. 0 446599 Z97832 Hs. 15476 differential expressed in FDCP (mouse 3. 0 412950 BE018581 Hs. 245342 hypothetical protein FLJ14642 3. 0 428670 AA431682 Hs. 134832 ESTs 3. 0 446975 BE246446 Hs. 16695 ubiquitin-activating enzyme El-like 3. 0 437756 AA767537 Hs. 197096 ESTs 3 0 416084 L16991 Hs. 79006 deoxythymidylate kinase (thymidylate kin 3. 0 402374 AL135225 Hs. 301865 dopachrome tautomerase (dopachrome delta 3. 0 443885 H91806 Hs. 15284 ESTs 3. 0

434008 AA740878 Hs. 112982 ESTs 3. 0 452568 AA805634 Hs. 300870 Homo sapiens mRNA ; cDNA DKFZp547M072 (fr 3. 0 414239 A1288330 Hs. 182330 ESTs 3. 0 421013 M62397 Hs. 1345 mutated in colorectal cancers 3. 0 424635 AA420687 Hs. 115455 Homo sapiens cDNA FLJ14259 fis, clone PL 3. 0 410276 A1554545 Hs. 68301 ESTs 3. 0 433865 N29862 Hs. 44104 ESTs 3. 0 406028 3. 0 401626 3. 0 415949 H10562 Hs. 21691 ESTs 3. 0 418583 AA604379 Hs. 86211 hypothetical protein 3. 0 417933 X02308 Hs. 82962 thymidylate synthetase 3. 0 434577 R37316 Hs. 179769 Homo sapiens cDNA : FLJ22487fis, clone H 3. 0 430437 A) 768801 Hs. 169943 Homo sapiens cDNA FU13569 fis, clone PL 3. 0 427940 AA417812 Hs. 38775 ESTs 2. 9 456060 C14904 Hs. 45184 Homo sapiens cDNA FLJ12284 fis, clone MA 2. 9 421988 AW450481 Hs. 161333 ESTs 2. 9 448775 AB025237 Hs. 388 nudix (nucleoside diphosphate linked moi 2. 9 438598 A1805943 Hs. 326067 hypothetical protein MGC5178 2. 9 429612 AF062649 Hs. 252587 pituitary tumor-transforming 1 2. 9 451189 AA016019 Hs. 40905 ESTs 2. 9 401558 2. 9 426207 BE390657 Hs. 30026 HSPC182 protein 2. 9 404721 2. 9 401384 2. 9 417288 A) 984792 Hs. 108812 hypothetica) protein FLJ22004 2. 9 427648 AI376722 Hs. 180062 proteasome (prosome, macropain) subunit 2. 9 435928 H64345 Hs. 183961 ESTs 2. 9 431740 N75450 Hs. 183412 ESTs, ModeratelysimilartoAF11672167 2. 9 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 2. 9 439972 A1348100 Hs. 124662 ESTs 2. 9 433112 AA973801 Hs. 144553 ESTs, Weakly similar to unnamed protein 2. 9 423751 AW235633 Hs. 46525 ESTs 2. 9 406748 AW339106 Hs. 217493 annexin A2 Z9 422154 T79045 Hs. 126927 ESTs 2. 9 405588 2 9 440911 AA909536 Hs. 143562 ESTs 2. 9 412420 AL035668 Hs. 73853 bone morphogenetic protein 2 2. 9 445043 AW014413 Hs. 196066 ESTs 2. 9 410114 AW590540 Hs. 271280 ESTs 2. 9 419217 AA504571 gb : aa60e12. r1 NCi_CGAP_GCB1 Homosapiens 2. 9 415849 R20529 Hs. 6806 ESTs 2. 9 448140 AF146761 Hs. 20450 BCM-like membrane protein precursor Z9 453331 A1240665 Hs. 8895 ESTs 2. 9 432065 AA401039 Hs. 2903 protein phosphatase 4 (formerly X), cata 2. 9 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 2. 9 454377 AA076811 gb : 7B03C12 Chromosome 7 Fetal Brain cDNA 2. 9 421491 H99999 Hs. 42736 ESTs 2. 9 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7, S. cerevisi 2. 8 415446 F08898 Hs. 66075 ESTs Z8 439518 W76326 gb : zd60dO4. r1 Soares feiai heart_NbHH19W 28 427221 L15409 Hs. 174007 vonHippei-Undausyndrome 28 422493 AW474183 Hs. 250173 hypothetical protein FLJ13158 2. 8 419451 Ai907117 Hs. 90535 syntaxin binding protein 2 2. 8 448789 BE539108 Hs. 22051 hypothetical protein MGC15548 2. 8 424126 AA335635 Hs. 96917 ESTs 2. 8 458695 AV660159 Hs. 282284 ESTs, Weakly similar to 138022 hypotheti 28 418973 AA233056 Hs. 191518 ESTs 2. 8 44Q471 AA886146 Hs. 307944 ESTs 2. 8 421016 AA504583 Hs. 101047 transcription factor 3 (E2A immunoglobul 2. 8 433647 AA603367 Hs. 222294 ESTs 2. 8 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 2. 8 421723 AA620400 Hs. 300717 sodium channel, voltage-gated, type 111, 2. 8 434964 A1638850 Hs. 130746 ESTs 2. 8 432022 AL162042 Hs. 272348 Homo sapiens mRNA ; cDNA DKFZp761L1212 (f 2. 8 400517 AF242388 Hs. 149585 lengsin 2. 8 433023 AW864793 Hs. 87409 thrombospondin 1 2. 8 448734 BE614070 Hs. 326416 Homo sapiens mRNA ; cDNADKFZp564H1916 (f 2. 8 406736 Api254733 Hs. 182426 ribosome protein S2 2. 8 409207 AW373564 Hs. 194637 BANP homolog, SMAR1 homolog 2. 8 440196 N72847 Hs. 125221 ESTs 2. 8 403961 2. 8 425193 AW965689 Hs. 22509 ESTs 2. 8 425268 Ai807883 Hs. 180059 Homo sapiens cDNA FLJ20653 fis, clone KA 2. 8 440483 A1200836 Hs. 150386 ESTs 2. 8 412391 AW947710 gb : RCO-MT0004-130300-011-e07 MT0004 Homo 2. 8 448769 N66037 Hs. 38173 ESTs 2. 8 411632 AW854829 gb : QV2-CT0261-201099 011-fO1 CT0261 Homo 2. 8 438221 A1798853 Hs. 122224 ESTs, Weakly similar to ALU5_HUMAN ALU S 2. 8 457578 AA578027 gb : ni20hO1. s1 NCI CGAP HSC1 Homo sapiens 2. 8 455510 AA422029 Hs. 143640 ESTs, Weaklysimiiariohyperpoiariza60 28 447769 AW873704 Hs. 320831 Homo sapiens cDNA FW14597 fis, done NT 2. 8 427701 AA411101 Hs. 243886 nuclear autoantigenic sperm protein (his 2. 8

433800 A1034361 Hs. 135150 lung iype-l ceii membrane-essociated g ! y 2. 8 439662 H97552 Hs. 269060 ESTs 2. 8 425694 U51333 Hs. 159237 hexokinase 3 (white cell) 28 414747 U30872 Hs. 77204 centromere protein F (350/400kD, mitosin 2. 8 414598 Ai094221 Hs. 135150 tungtype-iceii membrane-associated gly 2. 8 447752 M73700 Hs. 105938 lactotransfenin 2. 8 408761 AA057264 Hs. 238936 ESTs, Weakly similar to (define not ava Z8 453350 Api917771 Hs. 61790 hypothetical protein FLJ23338 2. 7 456629 AW891965 Hs. 279789 histone deacetylase 3 2. 7 439538 AA837323 Hs. 164047 ESTs 27 458814 A1498957 Hs. 170861 ESTs, Weakly sinfilar to Zl 95_HUMAN Zi NC 2. 7 456029 BE255990 Hs. 218329 hypothetical protein 2. 7 451129 BE072881 gb : RC2-BT0548-200300-012-e09BT0548Homo 2. 7 456412 AW749617 Hs. 280776 tankyrase, TRF1-interacGng ankyrin-rela 2. 7 453536 AA137000 Hs. 62578 ESTs 2. 7 438378 AW970529 Hs. 86434 hypothetical protein FU21816 2. 7 425745 U44060 Hs. 14427 Homo sapiens cDNA : FLJ21800 fis, clone H 2. 7 446322 N23033 Hs. 155814 ESTs 2. 7 451592 A1805416 Hs. 213897 ESTs 2. 7 429466 M85835 Hs. 12827 ESTs 2. 7 429747 M87507 Hs. 2490 caspase 1, apoptosis-related cysteine pr 2. 7 455514 AW983871 gb : RC1-HN0003-220300-021-h07 HN0003 Homo 2. 7 414732 AW410976 Hs. 77152 minichromosome maintenance deficient (S. 2. 7 444207 AI565004 Hs. 79572 cathepsin D (lysosomal aspartyl protease 2. 7 427421 AA402414 Hs. 3059 coatomer protein complex, subunit beta 2. 7 449655 A1021987 Hs. 59970 ESTs 2. 7 422648 D86983 Hs. 118893 Melanoma associated gene 2. 7 428494 AA233439 Hs. 184634 hypothetical protein FLJ20005 2. 7 406895 X60648 Hs. 172550 poiypyrimidine tract binding protein (he 2. 7 453255 AA278167 Hs. 19215 Homo sapiens, clone IMAGE : 3605822, mRNA 2. 7 427348 NM014137 Hs. 177258 PR00650 protein 2. 7 435370 Ai964074 Hs. 225838 ESTs 2. 7 407862 BE548267 Hs. 50724 Homo sapiens cDNA FLJ10934 fis, done OV 2. 7 411874 AA096106 Hs. 20403 ESTs 2. 7 421192 AA833718 Hs. 204529 KIM1808 protein 2. 7 435899 W89093 Hs. 189914 ESTs 2. 7 414603 R58394 Hs. 25119 ESTs, Weakly similar to YEXO_YEAST HYPOT 2. 7 453462 AL037291 Hs. 236605 ESTs, Moderately similar to AW4_HUMAN A 2. 7 436554 A1985810 Hs. 301173 ESTs 2. 7 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. Z7 403881 2. 7 431779 AW971178 Hs. 268571 apolipoprotein Cl 2. 7 404984 2. 7 448275 BE514434 Hs. 20830 kinesin-like 2 2. 7 446839 BE091926 Hs. 16244 mitoticspindtecoi) ed-coitre) atedprot 2. 7 411927 BE274009 Hs. 772 glycogen synthase 1 (muscle) 2. 7 404756 Z7 447072 D61594 Hs. 17279 tyrosytproteinsuifotransferasel 2. 7 422176 H80977 gb : yu89a11. s1 Soares fetal liver spleen 2. 7 439627 BE621702 Hs. 29076 hypothetical protein FLJ21841 Z7 436532 AA721522 gb : nv54h12. r1 NCf CGAP_Ew1 Homosapiens 2. 7 412833 AW960547 Hs. 298262 ribosome protein S19 2. 7 457245 A1745498 Hs. 204579 ESTs 2. 7 446861 Ai696519 Hs. 14427 Homo sapiens cDNA : FLJ21800 fis, clone H 2. 7 453263 R91778 Hs. 99369 ESTs 2. 7 459385 BE380047 gb : 601159362F2 NIH_MGC 53 Homo sapiens c 2. 7 438764 AA824524 Hs. 336452 ESTs 27 429285 A1971081 Hs. 20432 ESTs, Weakly similar to 138022 hypotheti 2. 7 424853 BE549737 Hs. 132967 Human EST done 122887 manner transpose 2. 7 430037 BE409649 Hs. 227789 mitogen-activated protein kinase-activat Z7 449892 N73608 Hs. 50309 ESTs 2. 7 454201 AB023191 Hs. 44131 KIAA0974 protein 2. 7 452279 AA286844 Hs. 61260 hypothetical protein FLJ13164 2. 7 427954 J03060 Hs. 247551 metaxin 1 2. 7 400371 U80740 2. 7 452449 AW068658 Hs. 20943 ESTs 2. 7 431114 AA492400 Hs. 291015 ESTs Z7 417088 M54915 Hs. 81170 pim-1 oncogene 2. 7 447674 BE270640 Hs. 19192 cydin-dependent kinase 2 2. 7 403680 Z7 454679 AW813110 gb : CM4-ST0189-051099-021-fi05 ST0189 Homo 2. 7 411968 Api207410 Hs. 69280 Homo sapiens, clone I MAGE : 3636299, mRNA, 2. 6 422240 R60594 Hs. 29002 KIAA1706 protein 2. 6 424368 AB037766 Hs. 146085 KiM1345 protein 2. 6 405808 2. 6 419700 AF084935 Hs. 92357 galactolcinase 1 2. 6 435972 W95088 Hs. 114198 ESTs 2. 6 453568 S70782 Hs. 557 adrenergic, alpha-lD-, receptor 2. 6 443725 AW245680 Hs. 9701 growth arrest and DNA-damage-inducible, 2. 6 444156 AW500059 Hs. 86437 ESTs, HightysimilartoAF219140 1 gastr 2. 6 428209 AA424197 Hs. 98947 ESTs, Weakly similar to S33496 trypsin 1 2. 6 437640 AA764893 Hs. 272155 ESTs, Weaklysimilartoi38022hypothe6 2. 6 453948 A1970797 Hs. 64859 ESTs 2. 6

415402 AA164687 Hs. 177576 mannosyi (alpha-1, 3-)-glycoprotein beta-2. 6 425397 J04088 Hs. 156346 topoisomerase (DNA) it alpha (170kD) 26 418228 AA962181 Hs. 111219 ESTs, ModeratelysimilartoALU1_HUMANA Z6 401324 2. 6 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypotheti 2. 6 443210 Ai692649 Hs. 9451 hypothetical protein MGC13168 2. 6 457244 AA581385 Hs. 162473 ESTs, Weakly similar to 138022 hypotheff 2. 6 417144 AA382104 Hs. 81337 lecfin, galactoside-binding, soluble, 9 2. 6 433933 Al754389 Hs. 133494 Homo sapiens clone TCCCIA00164 mRNA sequ 2. 6 437437 AA226869 Hs. 16520 hypothetical protein DKFZp762L0311 2. 6 434206 AW136973 Hs. 288516 ESTs, Weakly similar to S69890 mitogen i 26 400992 2. 6 455530 AW984744 gb : RC1-HN0015-040400-011-d03 HN0015 Homo 2. 6 436139 AA765786 Hs. 120936 ESTs 2. 6 448330 AL036449 Hs. 207163 ESTs 2. 6 412942 AL120344 Hs. 75074 mitogen-acfivated protein kinase-activat 2. 6 432753 NM 014075 Hs. 336938 Homo sapiens PR00593 mRNA, complete cds 2. 6 433430 A1863735 Hs. 186755 ESTs 2. 6 436693 AW973223 Hs. 303197 B-ceD CLLllymphoma 7C 2. 6 429482 AF076974 Hs. 203952 iransformationltranscription domain-asso 2. 6 432715 AA247152 Hs. 200483 ESTs, Weakly similar to KIAA1074 protein 2. 6 414217 A1309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 2. 6 434165 AA971328 Hs. 95361 myosin VIIA (Usher syndrome 1B (autosoma 2. 6 414835 AA156720 Hs. 185342 ESTs 2. 6 424489 T48851 Hs. 149250 D-siglec precursor, 2. 6 436496 AA281959 Hs. 5210 glia matura6on factor, gamma 2. 6 403797 2. 6 434573 AW372340 Hs. 159717 ESTs 2. 6 418841 NM 002332 Hs. 89137 low density lipoprotein-related protein 2. 6 415785 R82419 Hs. 23603 ESTs, Moderately similar to ALUB_HUMAN A 2. 6 450608 AA010365 Hs. 193229 ESTs 2. 6 425304 AA463844 Hs. 31339 fibroblast growth factor 11 2. 6 432268 BE311856 Hs. 274230 3'-phosphoadenosine 5'-phosphosulfate sy 2. 6 410507 AA355288 Hs. 40834 transitiona) epithe) ia response protein 2. 6 427343 Ai880044 Hs. 176977 protein kinase C binding protein 2 2. 6 420917 AW135716 Hs. 117330 ESTs 2. 6 414399 L47345 Hs. 155202 transcription e) ongation factor B (Stii) 2. 6 446089 Api860021 Hs. 270651 ESTs, Moderately similar to A47582 B-cel 2. 6 440829 AF136407 Hs. 7446 chromosome 6 open reading frame 5 2. 6 408475 AA315514 Hs. 47986 hypothetical protein MGC10940 2. 6 450946 AA374569 Hs. 127698 ESTs, Moderately similar to 2109260A B c 2. 6 421462 AF016495 Hs. 104624 aquaporin 9 2. 6 434846 AW295389 Hs. 119768 ESTs 2. 6 422887 A1751848 Hs. 49215 ESTs 2. 6 417435 NM 005181 Hs. 82129 carbonic anhydrase 111, muscle specific 2. 6 437389 AL359587 Hs. 271586 hypothetical protein DKFZp762M115 2. 5 408981 AW500797 Hs. 49427 Gem-interacting protein 2. 5 432180 Y18418 Hs. 272822 RuvB (E coli homolog)-like 1 2. 5 418079 R40058 Hs. 6911 ESTs 2. 5 437820 AA769062 Hs. 323836 ESTs, Weakly similar to alternatively sp 2. 5 439685 AW956781 Hs. 293937 ESTs, Weakly similar to FXD2_HUMAN FORKH 2. 5 425681 AB018297 Hs. 159183 KIAA0754 protein 2. 5 435177 A1018174 Hs. 42936 ESTs 2. 5 437323 AA371145 Hs. 226627 lepton receptor 2. 5 422114 AW194851 Hs. 111801 arsenate resistance protein ARS2 2. 5 448478 A1523218 Hs. 203456 ESTs 2. 5 426623 AA382826 Hs. 132793 ESTs 2. 5 448764 A1568607 Hs. 182112 ESTs 2. 5 458385 A1051489 Hs. 246214 ESTs 2. 5 403726 N28939 Hs. 13434 Homo sapiens clone 24418 mRNA sequence 2. 5 444888 Ai651039 Hs. 148559 ESTs 2. 5 456179 H75490 Hs. 271930 ESTs 2. 5 424840 D79987 Hs. 153479 extra spindle poles, S. cerevisiae, homo 2. 5 406273 NM 000919 Hs. 83920 peptidylglycine alpha-amidating monooxyg 2. 5 418054 NM_002318 Hs. 83354 lysyl oxidase-like 2 2. 5 445936 BE543594 Hs. 61478 hypothetical protein FLJ22329 2. 5 454967 AW848276 gb : IL3-CT0214-150200-074-E06 CT0214 Homo 2. 5 442303 AA989289 Hs. 129169 ESTs 2. 5 456583 AF179897 Hs. 104105 Meis (mouse) homo) 2 2. 5 434263 N34895 Hs. 44648 ESTs 2. 5 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 2. 5 424528 AW073971 Hs. 238954 ESTs, Weakly similar to KIAA1204 protein 2. 5 406038 Y14443 Hs. 88219 zinc finger protein 200 2. 5 413495 Y12395 Hs. 315177 interferon-related developmental regulat 2. 5 423098 AA321980 Hs. 204682 ESTs 2. 5 410817 A1262789 Hs. 93659 protein disulfide isomerase related prot 2. 5 439841 AF038961 Hs. 6710 mannose-P-dolichol utiiization defect 1 2. 5 453828 AW970960 Hs. 293821 ESTs 2, 5 445034 AW293376 Hs. 143659 ESTs 2. 5 449620 BE407797 Hs. 23794 checkpoint with forkhead and ring finger 2. 5 406876 Api382286 Hs. 180842 ribosome protein L13 2. 5 412370 AW946614 gb : RC2-ET0021-280400-011-c05 ET0021 Homo 2. 5 423642 AW452650 Hs. 157148 hypothetical protein MGC13204 2. 5

430357 AW976789 Hs. 165607 ESTs 2. 5 414853 U31116 Hs. 77501 sarcoglycan, beta (43kD dystrophin-assoc 2. 5 416097 BE387371 Hs. 118964 hypothetical protein FLJ20085 2. 5 428619 AK002140 Hs. 187378 hypothetical protein FLJ11278 2. 5 413976 BE295452 Hs. 75655 procollagen-proline, 2-oxoglutarate 4-di 2. 5 445223 AW291553 Hs. 254983 ESTs Z5 423926 X03833 Hs. 1722 interleukin 1, alpha 2. 5 410165 BE560228 Hs. 71869 apoptosis-associated speck-like protein 2. 5 406474 2. 5 433908 AW298141 Hs. 157975 ESTs 2. 5 439755 AW748482 Hs. 77873 B7 homolog 3 2. 5 437528 N59646 Hs. 169745 crumbs (Drosophila) homolog 1 2. 5 420734 AW972872 Hs. 293736 ESTs 2. 5 415346 Z43108 gb : HSC13E071 normalized infant brain cDN 2. 5 419337 AW291112 Hs. 209978 ESTs 2. 5 444606 R09478 Hs. 18041 ESTs 2. 5 430061 AB037817 Hs. 230188 KIAA1396 protein 2. 5 413407 Api356293 Hs. 75339 inositol polyphosphate phosphatase-like 2. 5 411965 BE467339 Hs. 280115 ESTs 2. 5 409278 AA346683 Hs. 52763 anaphase-promoting complex subunit 7 2. 5 403142 2. 5 401714 2. 5 425081 X74794 Hs. 154443 minichromosome maintenance deficient (S. 2. 5 416505 H66470 Hs. 16004 ESTs 2. 5 431518 AA743462 Hs. 165337 ESTs 2. 5 448623 BE613468 Hs. 107515 ESTs, Weakly similar to T00329 hypothe6 2. 5 428301 AW628666 Hs. 98440 ESTs, Weakly similar to 138022 hypotheti 2. 5 404366 2. 5 449733 R74546 Hs. 29438 Homo sapiens cDNA FLJ12094 fis, clone HE 2. 5 459583 AI907673 gb : IL-BT152-080399-004 BT152 Homo sapien 2. 5 402856 AW939659 gb : RCO-DT0076-110100-031-cO9 DT0076 Homo 2. 5 420751 J03019 Hs. 99913 adrenergic, beta-1-, receptor 2. 4 436805 AA731533 Hs. 270751 ESTs 2. 4 420285 AA258124 Hs. 293878 ESTs, ModeratelysimilartoZN91_HUMANZ 2. 4 453496 AA442103 Hs. 33084 solute carrier family 2 (facilitated glu 2. 4 453853 AL040600 Hs. 188083 ESTs 2. 4 407909 AW103986 gb : xd63eO6. x1 NCI CGAP_Ov23 Homo sapiens 2. 4 454630 BE142075 gb : CM3-HT0137-170999-012-fO2 HT0137 Homo 2. 4 451026 AA013218 Hs. 157492 cer-d4 (mouse) homotog 2. 4 420779 L12398 Hs. 99922 dopamine receptor D4 2. 4 438322 AA804170 Hs. 221349 ESTs 2. 4 455908 BE156306 gb : QVO-HT0367-150200-114-h04 HT0367 Homo 2. 4 419625 U91616 Hs. 91640 nuclear factor of kappa light polypeptid 2. 4 440773 AA352702 Hs. 332541 Homo sapiens, Similar to RIKEN cDNA 2700 2. 4 450823 T81223 Hs. 22011 complement-clq tumor necrosis factor-rel 2. 4 447247 AW369351 Hs. 287955 Homo sapiens cDNA FLJ13090 fis, clone NT 2. 4 429109 AL008637 Hs. 196352 neutrophil cytosolic factor 4 (40kD) 2. 4 451802 A1817711 Hs. 209374 ESTs 2. 4 419417 R92491 Hs. 39429 ESTs 2. 4 407094 AF000574 Hs. 22405 leukocyte immunoglobulin-like receptor, 2. 4 423567 BE252949 Hs. 69331 hypotheGcalprotein FLJ13633 2. 4 427501 A1369280 Hs. 131743 ESTs 2. 4 451773 Z42044 Hs. 26996 KIAA1278 protein 2. 4 436845 AA732297 Hs. 113928 ESTs 2. 4 431584 AW296121 Hs. 266263 Homo sapiens CDNA FLJ 14115 fis, clone MA 2. 4 440614 AA781530 Hs. 127236 hypothetical protein FLJ12879 2. 4 423721 AF176911 Hs. 132004 cardiotrophin-like cytokine ; neurotrophi 2. 4 452125 BE312642 Hs. 28077 GDP-mannose pyrophosphorylase B 2. 4 419508 AW997938 Hs. 90786 ATP-binding cassette, sub-family C (CFTR 2. 4 453446 BE299996 gb : 600944574F1 NIH_MGC_17 Homo sapiens c 2. 4 419792 AA250890 Hs. 190037 ESTs 2. 4 452786 R61362 Hs. 106642 ESTs, Weakly similar to T09052 hypothefi 2. 4 410447 AW816134 gb : MR3-ST0220-290100-016-e04 ST0220 Homo 2. 4 438662 AA223599 Hs. 6351 cleavage and polyadenylation specific fa 2. 4 402408 2. 4 443950 Nu-001425 Hs. 9999 epithelial membrane protein 3 2. 4 414625 AA335738 Hs. 76686 glutathione peroxidase 1 2. 4 403048 2. 4 432088 AA525454 gb : ni85cO9. s1 NCi_CGAP_Pr20 Homo sapiens 2. 4 431692 AL021331 Hs. 267749 unc93 (C. eiegans) homolog A 2. 4 455023 AW850907 gb : L3-CT0220-310100-065-H11 CT0220Homo 2. 4 426249 F05422 Hs. 168352 nucleoporin-like protein 1 2. 4 446795 Ai797713 Hs. 156471 ESTs 2. 4 414774 X02419 Hs. 77274 plasminogen activator, urokinase 2. 4 414252 AA346483 Hs. 126191 ESTs 2. 4 417918 AA209205 Hs. 163754 hypothetical proteinFFJ12606 2. 4 427550 BE242818 Hs. 179606 nuclear RNA helicase, DECD variant of DE 2. 4 404020 2. 4 407846 AA426202 Hs. 40403 Cbp/p300-interacting transacGvator, wit 2. 4 417222 AiS25424 Hs. 42053 hypothetical protein MGC2383 2. 4 443639 BE269042 Hs. 9661 proteasome (prosome, macropain) subunit, 2. 4 452706 AW449390 Hs. 257150 ESTs, ModeratelysimilartoSUR1_HUMANS 2. 4 401676 2. 4

428882 AA436915 Hs. 131748 ESTs, Moderately similar to ALU7 HUMAN A 2. 4 436277 R88520 Hs. 120917 ESTs 2. 4 426271 AF026547 Hs. 169047 chondroitin sulfate proteoglycan 3 (neur 2. 4 405353 2. 4 409193 AA131483 gb : zoO8eO5. r1 Stratagene neuroepithelium 2. 4 431431 AL096711 Hs. 252953 Human DNA sequence from clone RP3-403A15 2. 4 407889 R34556 Hs. 30800 ESTs, Weakly similar to S65657 alpha-1 C-2. 4 453335 AW857376 Hs. 169238 fucosyltransferase 3 (galactoside 3 (4)-L 2. 4 450621 AW297288 Hs. 55918 hypothetical protein FLJ11354 2. 4 419652 AL157485 Hs. 91973 hypothetical protein 2. 4 421151 BE174431 Hs. 63386 ESTs 2. 4 437846 AA773866 Hs. 244569 esophagus cancer-related gene-2 2. 4 420681 AA847602 Hs. 106510 ESTs, Moderately similar to ALU2_HUMAN A 2. 4 405288 2. 4 453527 R49570 Hs. 180236 ESTs 2. 4 429875 A1091815 gb : qa58b06. s1 Soares NhHMPu S1 Homosapi 2. 4 436360 A1962796 Hs. 136754 ESTs 2. 4 418592 X99226 Hs. 284153 Fanconi anemia, complementation group A 2. 4 419991 AJ000098 Hs. 94210 eyes absent (Drosophila) homolog 1 2. 4 449539 W80363 Hs. 58446 ESTs 2. 4 419870 AW403911 Hs. 266175 phosphoprotein associated with GEMs 2. 4 404584 2. 4 454276 AW294996 Hs. 255374 ESTs 2. 4 423746 AW361817 Hs. 132370 NADPH oxidase 1 2. 4 415558 AA885143 Hs. 125719 ESTs 2. 4 428141 D50402 Hs. 182611 solute camer family 11 (proton-coupled 2. 4 406953 L36847 gb : Human (clone p17/90) rearranged iduro 2. 4 444471 AB020684 Hs. 11217 KIAA0877 protein 2. 4 451031 A1360187 Hs. 4254 ESTs 2. 4 455302 AW997641 gb : RC6-BN0052-170200-011-D06BN0052Homo 2. 4 449063 Ai627352 Hs. 236547 Homo sapiens, done IMAGE : 2905978, mRNA, 2. 4 401048 2. 4 434420 AA688278 Hs. 194864 hypothetical protein FLJ22578 2. 4 425848 BE242709 Hs. 159637 valyl-tRNAsynthetase2 2. 4 449086 A1628357 Hs. 208037 ESTs 2. 4 415238 R37780 Hs. 21422 ESTs 2. 4 448337 AW206453 Hs. 3782 ESTs 2. 4 416991 N36389 Hs. 141296 KIAA0226 gene product 2. 3 412600 L28824 Hs. 74101 spleen tyrosine kinase 2. 3 418385 AW590613 Hs. 301040 Homo sapiens, clone IMAGE : 3357127, mRNA, 2. 3 440769 BE561793 Hs. 21446 KIAA1716 protein 2. 3 450437 X13956 Hs. 24998 hypothetical protein MGC10471 2. 3 412035 N78559 Hs. 293629 hypothetical protein MGC3121 2. 3 406739 AI566709 Hs. 182426 ribosomal protein S2 2. 3 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 2. 3 410286 A1739159 Hs. 61898 DKFZP586N2124 protein 2. 3 443740 R56434 Hs. 21062 ESTs 2. 3 405605 2. 3 416913 AW934714 gb : RC1-DT0001-031299-011-all DT0001 Homo 2. 3 426509 M31166 Hs. 2050 pentaxin-related gene, rapidly induced b 2. 3 445828 F05802 Hs. 81907 ESTs 2. 3 457195 AB011099 Hs. 196647 KIAA0527 protein 2. 3 420372 AW960049 Hs. 293660 Homo sapiens, clone IMAGE : 3535476, mRNA, 2. 3 423198 M81933 Hs. 1634 cell division cycle 25A 2. 3 457730 AW753613 gb : RC1-CT0268-060100-013-e01 CT0268 Homo 2. 3 412014 AI620650 Hs. 43761 ESTs, Weakly similar to A46010 X-linked 2. 3 447131 NM 004585 Hs. 17466 retinoic acid receptor responder (tazaro 2. 3 446288 AW189209 Hs. 149708 ESTs 2. 3 436954 AA740151 Hs. 130425 ESTs 2. 3 411658 AW855598 gb : CM1-CT0278-031199-032-e08 CT0278 Homo 2. 3 404240 2. 3 456094 H95091 gb : yw57a09. r1 Soares_placenta_8io9weeks_ 2. 3 416951 AA190926 Hs. 190785 ESTs, Moderately similar to S65657 alpha 2. 3 406737 A1356586 gb : qy15h09. xl NCLCGAP_Brn23 Homo sapien 2. 3 458453 A1097452 Hs. 135095 ESTs 2. 3 452330 A1879127 Hs. 191979 KIAA1733 protein 2. 3 408523 AW833259 Hs. 314287 ESTs 2. 3 455470 AW947992 gb : PMO-MT0011-240300-001-cO9MT0011 Homo 2. 3 436323 R17697 Hs. 140963 ESTs, Weakly similar to 138022 hypotheti 2. 3 450000 A1952797 Hs. 10888 hypothetical protein FU21709 2. 3 416171 H23896 Hs. 125790 leucine-rich repeat-containing 2 2. 3 419134 T89863 Hs. 221771 ESTs 2. 3 445933 AV655733 Hs. 293860 spinster-like protein 2. 3 422089 AA523172 Hs. 103135 ESTs, Weakly similar to SFR4_HUMAN SPLIC 2. 3 449911 A1262106 Hs. 12653 ESTs 2. 3 417079 U65590 Hs. 81134 interleukin I receptor antagonist 2. 3 411742 AW247593 Hs. 71819 eukaryotic translation initiation factor 2. 3 435615 Y15065 Hs. 4975 potassium voltage-gated channel, KQT-lik 2. 3 423491 AA191765 Hs. 129673 eukaryotic translation initiation factor 2. 3 407182 AA312551 Hs. 230157 ESTs 2. 3 411448 AA178955 Hs. 271439 ESTs, Weakly similar to 138022 hypothe6 2. 3 438644 A1126162 Hs. 129037 ESTs 2. 3 432691 U29725 Hs. 3080 mitogen-activated protein kinase 7 2. 3

452198 A1097560 Hs. 61210 ESTs, Weakly similar to 138022 hypotheti 2. 3 411125 AA151647 Hs. 68877 cytochrome -245, alpha polypeptide 2. 3 404054 2. 3 430458 AA479300 Hs. 225706 ESTs, Weakly similar to 138022 hypotheti 2. 3 440210 AW674562 Hs. 125296 ESTs 2. 3 446727 AB011095 Hs. 16032 KIAA0523 protein 2. 3 453775 NM OOZ916 Hs. 35120 replication factor C (activator 1) 4 (37 2. 3 438379 N23018 Hs. 171391 C-terminal binding protein 2 2. 3 449919 Api674685 Hs. 200141 ESTs 2. 3 415293 R49462 Hs. 106541 ESTs 2. 3 441126 Nom-000429 Hs. 323715 melhionineadenosyltransterasel, alpha 2. 3 408203 AA053137 Hs. 42390 nasopharyngeat carcinoma susceptibility 2. 3 434941 AW073202 Hs. 334825 Homo sapiens cDNA FW14752 fis, clone NT 2. 3 450748 A1733093 Hs. 130016 ESTs 2. 3 404185 2. 3 418327 U70370 Hs. 84136 paired-like homeodomain transcription fa 2. 3 451370 A1791929 Hs. 300782 ESTs 2. 3 400034 2. 3 407723 AW071161 Hs. 252873 ESTs 2. 3 431320 AW969474 Hs. 183070 ESTs 2. 3 429271 AF039850 Hs. 198515 dead ringer (Drosophila)-like 1 2. 3 453707 AW003879 Hs. 126522 Homo sapiens, clone MGC : 16722, mRNA, com 2. 3 419225 U70073 gb : HSU70073 Human Homo sapiens cDNA clon 2. 3 444656 A1277924 Hs. 145199 ESTs 2. 3 405741 2. 3 400917 2. 3 432567 AA736777 Hs. 293770 ESTs 2. 3 437949 U78519 Hs. 41654 ESTs, Weakly similar to A46010 X-linked 2. 3 450514 AC005785 Hs. 25059 A kinase (PRKA) anchor protein 8 2. 3 418400 BE243026 Hs. 301989 KIAA0246 protein 2. 3 444019 BE173977 Hs. 10098 putative nucleolar RNA helicase 2. 3 406326 2. 3 412077 N51107 Hs. 47199 ESTs. Weakly similar to FU00004 protein 2. 3 427647 W19744 Hs. 180059 Homo sapiens cDNA FLJ20653 fis, clone KA 2. 3 414528 AA148950 Hs. 188836 ESTs 2. 3 414854 BE546797 Hs. 51483 ESTs, Weakly similar to hypothetical pro 2. 3 420352 BE258835 gb : 601117374F1 NIH MGC 16Homosapiensc 2. 3 439467 AW292275 Hs. 158365 ESTs 2. 3 402627 2. 3 451711 AK000461 Hs. 26890 caf eye syndrome chromosome region, cand 2. 3 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 2. 3 423869 BE409301 Hs. 134012 C1q-relatedfactor 2. 3 405915 2. 3 431503 NM012129 Hs. 258576 claudin 12 2. 3 423306 W88562 Hs. 108198 ESTs 2. 3 443232 AF161521 Hs. 9081 phenylalanyl-tRNA synthetase beta-subuni 2. 3 433064 D79991 Hs. 30002 SH3-containing protein SH3GLB2 ; KIAA1848 2. 3 434437 A1912566 Hs. 187813 ESTs 2. 3 436191 BE407866 Hs. 170253 hypothetical protein FLJ23282 2. 3 420006 H14429 Hs. 94300 serologically defined colon cancer antig 2. 3 447942 F12628 Hs. 334786 hypothetica) protein MGC16040 2. 3 403166 2. 3 422119 A1277829 Hs. 111862 K) AA0590geneproduct 2. 3 403751 2. 3 426451 Api908165 Hs. 169946 GATA-binding protein 3 2. 3 427413 BE547647 Hs. 177781 hypothetical protein MGC5618 2. 3 409091 AW970386 Hs. 269423 ESTs 2. 3 440491 R35252 Hs. 24944 ESTs, Weakly similar to 2109260A B cell 2. 3 427722 AK000123 Hs. 180479 hypothetical protein FU20116 2. 3 405747 2. 3 438210 AA780519 Hs. 311601 EST 2. 3 404652 2. 3 423524 AF055989 Hs. 129738 potassium voltage-gated channel, Shaw-re 2. 2 426793 X89887 Hs. 172350 HIR (histone cell cycle regulation defec 2. 2 444424 A1654684 Hs. 196377 ESTs 2. 2 434031 BE384165 Hs. 23723 pseudouridyiatesynthasel 2. 2 427650 AW501245 Hs. 252259 ribosome protein S3 2. 2 435220 D50030 Hs. 104 HGF activator 2. 2 438279 AA805166 Hs. 154762 HIV-1 rev binding protein 2 2. 2 424668 D83702 Hs. 151573 cryptochrome 1 (photolyase-like) 2. 2 429961 BE246829 Hs. 226770 DKFZP566C0424 prolein 2. 2 442065 A1831229 Hs. 128417 hypotheGcal protein FU14009 2. 2 415198 AW009480 Hs. 943 natural killer cell transcript 4 2. 2 420536 AL117455 Hs. 275438 histone deacetylase 7A 2. 2 411263 BE297802 Hs. 69360 kinesin-like 6 (mitotic centromere-assoc 2. 2 443753 AW367578 Hs. 134749 ESTs 2. 2 423243 AA351938 Hs. 23964 sin3-associated polypeptide, lBkD 2. 2 446572 AV659151 Hs. 282961 ESTs 2. 2 412247 AF022375 Hs. 73793 vascular endolhelial growth tactor 2. 2 421040 AA715026 Hs. 135280 ESTs 2. 2 426212 S71824 Hs. 167988 neuratceftadhesionmotecufel 2. 2 455584 BE007420 gb : PM3-BN0142-200300-001-c04 BN0142 Homo 2. 2 406851 AA609784 Hs. 180255 major histocompa6bility complex, class 2. 2

444153 AK001610 Hs. 10414 hypothetical protein FLJ10748 2. 2 419575 U43431 Hs. 91175 topoisomerase (DNA) III alpha 2. 2 418672 L44284 Hs. 159743 ESTs 2. 2 456261 AA210718 Hs. 104157 ESTs. Weakly similar to KIAA0694 protein 2. 2 415737 AA167626 Hs. 118743 ESTs 2. 2 447554 Api391598 Hs. 36119 ESTs, Weakly similar to ALUI-HUMAN ALU S 2. 2 405159 2. 2 442177 AW661820 Hs. 211413 ESTs 2. 2 446139 H77395 Hs. 39749 ESTs 2. 2 458339 AW976853 Hs. 172843 ESTs 2. 2 401876 2. 2 439566 AF086387 gb : Homo sapiens tull length insert cDNA 2. 2 425079 H09963 Hs. 2257 vitronectin (serum spreading factor, som 2. 2 441837 AA361743 Hs. 179881 core-binding factor, beta subunit 2. 2 430644 AB015419 Hs. 247710 preproprotactin-reteasingpeptide 2. 2 431474 AL133990 Hs. 190642 ESTs 2. 2 407739 NM 002285 Hs. 38070 tymphoid nuclear protein related to AF4 2. 2 424244 AV647184 Hs. 143601 hypothetical protein hCLA-iso 2. 2 438057 AW294544 Hs. 125785 ESTs, Weakly similar to CORB MOUSE CORNI 2. 2 412715 NM000947 Hs. 74519 pnmase, polypep6de 2A (58kD) 2. 2 422365 AF035537 Hs. 115521 REV3 (yeast homolog)-like, catalytic sub 2. 2 404170 2. 2 406902 M32074 gb : Human retinoic acid receptor gamma 2 2. 2 437902 AA770599 Hs. 144055 ESTs 2. 2 401012 2. 2 446502 A1302654 Hs. 208024 ESTs 2. 2 442554 AW467376 Hs. 129640 ESTs 2. 2 443021 AA368546 Hs. 8904 Ig superfamily protein 2. 2 421141 AW117261 Hs. 125914 ESTs 2. 2 443070 BE388662 Hs. 8984 Homo sapiens chromosome 14 BAC 98L12 2. 2 446566 H95741 Hs. 17914 membrane-spanning 4-domains, subfamily A 2. 2 427695 R88483 Hs. 172862 ESTs 2. 2 426503 AA380153 gb : EST93093 Skin tumor I Homo sapiens cD 2. 2 431468 AW248431 Hs. 256526 nuclear prelamin A recognition factor 2. 2 416185 AW975861 Hs. 47367 K) AA1785 protein 2. 2 437319 BE410958 Hs. 56406 Homo sapiens cDNA FLJ 13549 fis, clone PL 2. 2 402064 2. 2 413335 A1613318 Hs. 48442 ESTs 2. 2 408212 AA297567 Hs. 43728 hypothetical protein 2. 2 406169 2. 2 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 2. 2 407335 AA631047 Hs. 158761 Homo sapiens cDNA FLJ 13054 fis, clone NT 2. 2 409715 W42591 Hs. 23892 ESTs 2. 2 431921 N46466 Hs. 58879 ESTs 2. 2 443823 BE089782 Hs. 9877 hypothetical protein 2. 2 432458 A1968598 Hs. 78768 malignant cell expression-enhanced gene/2. 2 419726 U50330 Hs. 1274 bone morphogenetic protein 1 2. 2 423178 A1033140 Hs. 124983 Homo sapiens mRNA ; cDNA DKFZp564C142 (fr 2. 2 451089 AA903705 Hs. 4190 Homo sapiens cDNA : FLJ23269 fis, clone C 2. 2 415216 Api825905 Hs. 193211 HomosapienscDNAFW11421 hs, cloneHE 2. 2 442242 AV647908 Hs. 90424 Homo sapiens cDNA : FLJ23285 fis, clone H 2. 2 441830 AA383104 Hs. 42954 hypolheUcal prolein DKFZpS64D0372 2. 2 406660 X65371 Hs. 172550 polypyrimidine tract binding protein (he 2. 2 443378 AW392550 Hs. 9280 proteasome (prosome, macropain) subunit, 2. 2 432558 R97268 Hs. 177269 ESTs 2. 2 408146 R45621 Hs. 81057 hypothetical protein MGC2718 2. 2 419865 NM007020 Hs. 93502 U1-snRNP binding protein homolog (70kD) 2. 2 439444 A1277652 Hs. 54578 ESTs, Weakly similar to 138022 hypotheti 2. 2 438407 Api457122 Hs. 129673 eukaryotictransiationinitiationfactor 2. 2 450184 W31096 Hs. 237617 Homo sapiens, clone IMAGE : 3447394, mRNA, 2. 2 409130 BE076601 Hs. 75658 phosphorylase, glycogen : brain 2. 2 428844 AW972635 Hs. 301904 hypothefical protein FU12671 2. 2 429489 AF008203 Hs. 204039 aristaless-like homeobox 3 2. 2 433042 AW193534 Hs. 281895 HomosapienscDNAFLJ11660hs, cloneHE 2. 2 440658 H29142 Hs. 143032 ESTs, Weakly similar to neuronal thread 2. 2 408204 AA454501 Hs. 43666 protein tyrosine phosphatase type IVA, m 2. 2 427498 NM003926 Hs. 178728 methyl-CpG binding domain protein 3 2. 2 408006 H57654 Hs. 303345 ESTs, Weakly similar to 138022 hypotheti 2. 2 445703 AV654845 Hs. 27 glycine dehydrogenase (decarboxylating ; 2. 2 431446 AW294929 Hs. 255369 Homo sapiens cDNA FLi 10265 hs, clone HE 2. 2 456660 AA909249 Hs. 112282 solute carrierfamily 30 (zinc ransport 2. 2 433099 NM002504 Hs. 3187 nuclear transcription factor, X-box bind 2. 2 415857 AA866115 Hs. 127797 Homo sapiens cDNA FW 11381 fis, clone HE 2. 2 415245 N59650 Hs. 27252 ESTs 2. 2 443657 R14973 gb : yf42t10. s1 Soares fetal liverspleen 2. 2 402521 AW501216 Hs. 108945 KIAA0515 protein 2. 2 414819 BE177320 Hs. 156148 hypolhetical protein FU13231 2. 2 446530 AV658909 Hs. 282642 ESTs 2. 2 415797 A1291896 Hs. 72800 ESTs 2. 2 414812 X72755 Hs. 77367 monokine induced by gamma interferon 2. 2 453028 AB006532 Hs. 31442 RecO protein-like 4 2. 2 412133 U83460 Hs. 73614 soiute earner famiiy 31 (copper transpo 2. 2 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-0-sulfot 2. 2

437033 AW248364 Hs. 5409 RNA polymerase I subunit 2. 2 422732 AA577455 Hs. 24937 transformer-2 alpha (htra-2 alpha) 2. 2 416388 A1417358 Hs. 73677 ESTs 2. 2 452849 AF044924 Hs. 30792 hook2 protein 2. 2 446615 BE513202 Hs. 15589 PPAR binding protein 2. 2 428361 NM 015905 Hs. 183858 transcriptional intemediary factor 1 2. 2 446279 AA490770 Hs. 182382 ESTs 2. 2 422938 NM_001809 Hs. 1594 centromere protein A (17kD) 2. 2 403969 2. 2 410423 AW402432 Hs. 63489 protein tyrosine phosphatase, non-recept 2. 2 429736 AF125304 Hs. 212680 tumor necrosis factor receptor superfami 2. 2 447091 AW089648 Hs. 157779 ESTs, Weakly similar to CA17 HUMAN COLLA 2. 2 422017 NM_003877 Hs. 110776 STAT induced STAT inhibitor-2 2. 2 426728 NM 007118 Hs. 171957 hiple functonal domain (PTPRF interact 2. 2 438726 AB033103 Hs. 6385 KIAA1277 protein 2. 2 453315 BE544203 Hs. 24831 ESTs 2. 2 423244 AL039379 Hs. 209602 ESTs, Weakly similar to ubiquitous TPR m 2. 2 433610 AA806822 Hs. 112547 ESTs Z2 429451 BE409861 Hs. 202833 heme oxygenase (decycling) 1 2. 2 417980 R32235 gb : yh67fO8. r1 Soares placenta Nb2HP Homo 2. 2 406347 2. 2 414406 BE297904 gb : 601177814F1 NlH_MGC_17Homosapiensc 2. 2 401827 2. 2 446913 AA430650 Hs. 16529 transmembrane 4 superfamily member (tetr 2. 2 452294 AI871925 Hs. 117895 ESTs, Moderately similar to A47582 B-cel 2. 2 404084 2. 2 456786 AK002084 Hs. 132851 hypothefical protein FU11222 2. 2 435031 A1632091 Hs. 116877 ESTs 2. 2 442609 AL020996 Hs. 8518 selenoprotein N 2. 1 439732 AW629604 Hs. 167641 hypothetical protein from EUROIMAGE 1703 2. 1 421506 BE302796 Hs. 105097 ihymidine kinase 1, soluble 2. 1 439253 AF086064 Hs. 332252 ESTs 2. 1 409669 AW177551 Hs. 220255 hypothetical protein MGC13098 2. 1 429574 BE268321 Hs. 208912 hypothetical protein MGC861 2. 1 437470 AL390147 Hs. 134742 hypothe6cal protein DKFZp547D065 2. 1 408945 AW015089 Hs. 4964 DKFZP586J1624protein 2. 1 447687 A1627947 Hs. 150186 hypotheticalprotein DKFZp566K1946 2. 1 459584 Al910884 Hs. 207898 ESTs 2. 1 439130 AA306090 Hs. 124707 ESTs 2. 1 428180 Al129767 Hs. 182874 guanine nucleoUde binding protein (G pr 2. 1 442028 A1239437 Hs. 48945 ESTs 2. 1 430968 AW972830 gb : EST384925 MAGE resequences, MAGL Homo 2. 1 443609 AV650231 Hs. 282941 ESTs, Highly similar to A Chain A, Human 2. 1 417164 AA338283 Hs. 81361 heterogeneous nuclear ribonucleoprotein 2. 1 444534 AW271626 Hs. 42294 ESTs 2. 1 438391 A1262248 Hs. 25027 ESTs 2. 1 442003 AW297497 Hs. 201891 ESTs 2. 1 456278 BE300369 Hs. 289038 hypothetical protein MGC4126 2. 1 416976 BE243985 Hs. 80680 major vault protein 2. 1 417810 D28419 Hs. 82609 hydroxymethylbilane synthase 2. 1 445242 BE156478 Hs. 21108 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 1 452712 AW838616 gb : RCS-LT0054-140200-013D01 LT0054 Homo 2. 1 434926 BE543269 Hs. 50252 mitochondrial ribosomal protein L32 2. 1 421564 AB007864 Hs. 105850 KIAA0404 protein 2. 1 424927 AW973666 Hs. 153850 hypothetical protein C321D2. 4 2. 1. 432742 AA564453 Hs. 162339 ESTs 2. 1 435958 H98180 Hs. 117975 ESTs 2. 1 421531 AA713505 Hs. 291769 ESTs 2. 1 410431 BE261320 Hs. 158196 transcnptional adaplor 3 (ADA3, yeast h 2. 1 420503 Al570943 Hs. 337546 ESTs 2. 1 448127 A1478416 Hs. 282883 ESTs, WeaklysimilarloALU1_HUMANALUS 2. 1 452897 BE066058 Hs. 269233 ESTs, Moderately similar to 178885 serin 2. 1 447112 H17800 Hs. 7154 ESTs 2. 1 406577 2. 1 437162 AW005505 Hs. 5464 thyroid hormone receptor coactivating pr 2. 1 451460 A1797550 Hs. 209652 ESTs 2. 1 447402 H54520 Hs. 18490 hypothetical protein FU20452 2. 1 435828 AA700705 Hs. 13852 ESTs 2. 1 436396 A1683487 Hs. 152213 wingless-type MMTV integration site fami 2. 1 420582 BE047878 Hs. 99093 Homo sapiens chromosome 19, cosmid R2837 2. 1 452020 AA722012 Hs. 255757 ESTs, Weakly similar to AT2A_HUMAN POTEN 2. 1 415586 Z45481 gb : HSC2QE041 normalized infant brain cDN 2. 1 452620 AA436504 Hs. 119286 ESTs 2. 1 457066 BE244613 Hs. 158272 ESTs, Weakly similar to CA13 MOUSE COLLA 2. 1 435472 AW972330 Hs. 283022 triggering receptor expressed on myetoid 2. 1 431741 AA514783 Hs. 191701 ESTs 2. 1 446840 AW294828 Hs. 209203 ESTs 2. 1 440818 A1147060 Hs. 146726 ESTs 2. 1 410174 AA306007 Hs. 59461 DKFZP434C245 protein 2. 1 400822 2. 1 412760 AW379030 Hs. 41324 ESTs 2. 1 410653 BE383768 Hs. 65238 95 kDa reGnoblastoma protein binding pr 2. 1 426925 NM_001196 Hs. 315689 Homo sapiens cDNA : FLJ22373 fis, clone H 2. 1

424242 AA337476 Hs. 293984 hypothetical protein MGC13102 2. 1 452560 BE077084 Hs. 336432 ESTs 2. 1 456437 A1924228 Hs. 115185 ESTs, Moderately similar to PC4259 fem 2. 1 458922 BE501831 Hs. 282053 ESTs 2. 1 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 2. 1 419488 AA316241 Hs. 90691 nucleophosmin/nucleoplasmin 3 2. 1 411829 AW865749 gb : QV3-SN0021-100500-185-c03SN0021Homo 2. 1 457192 AL135682 Hs. 22452 HomosapiensmRNAforKIM1737pnolein, 2. 1 422128 AW881145 gb : QVO-OT0033-010400-182-aO7 OT0033 Homo 2. 1 452571 W31518 Hs. 34665 ESTs 2. 1 423699 H41850 Hs. 131846 PCAF associated factor 65 alpha 2. 1 406610 2. 1 453638 AW814996 gb : MR1-ST0206-170400-024-h09ST0206Homo 2. 1 418856 AA362858 gb : EST72900 Ovary 11 Homo sapiens cDNA 5 2. 1 437623 D63880 Hs. 5719 chromosomecondensafon-relaiedSMC-asso 2. 1 410908 AA121686 Hs. 10592 ESTs 2. 1 420221 N25991 Hs. 43725 ESTs 2. 1 424739 AA346108 Hs. 221610 ESTs 2. 1 425398 AL049689 Hs. 156369 hypothetical protein similar to tenascin 2. 1 424901 Z11933 Hs. 182505 POU domain, class 3, transcription facto 2. 1 411096 U80034 Hs. 68583 mitochondha) intermediate peptidase 2. 1 415635 F13168 gb : HSC3JF101 normalized infant brain cDN 2. 1 418181 U37012 Hs. 83727 cleavage and polyadenylation specific fa 2. 1 407103 AA424881 Hs. 256301 hypothetical protein MGC13170 2. 1 454389 AW752571 gb : IL3-CT0213-170100-055-F02 CT0213 Homo 2. 1 400021 2. 1 439228 N51700 gb : yy72d01. s1 Soares_mulUple_sclerosis_ 2. 1 456505 AA504595 Hs. 111418 ESTs 2. 1 405258 2. 1 444645 A1184564 Hs. 101654 ESTs 2. 1 430246 A1269069 Hs. 109268 hypothetical protein FU12552 2. 1 458687 AW024815 Hs. 170088 GLUT4 enhancer factor 2. 1 403857 2. 1 400258 2. 1 422221 AA306649 Hs. 169370 FYN oncogene related to SRC, FGR YES 2. 1 441054 AA913591 Hs. 126480 ESTs 2. 1 452700 Api859390 Hs. 288940 five-span transmembrane protein M83 zi 454606 AW809752 gb : MR4-ST0124-181299-020-b06 ST0124 Homo 2. 1 448954 A8014564 Hs. 22616 KIAA0664 protein 2. 1 443148 A1034357 Hs. 211194 ESTs, Weakly similar to ALU8 HUMAN ALU S 2. 1 453486 AL039201 Hs. 173554 ubiquinol-cylochromecreduclasecorepr 2. 1 437695 AA769202 Hs. 192142 ESTs 2. 1 425449 X52056 Hs. 157441 spleen focus forming virus (SFFV) provir 2. 1 447270 AC002551 Hs. 331 general transcription factor IIIC, polyp 2. 1 435677 AA694142 Hs293726 ESTs, Weakly similar to TSGA RAT TESTIS 2. 1 436382 AW977063 Hs. 250181 ESTs 2. 1 435837 Al689210 Hs. 187276 Homo sapiens cDNA FW11431 hs, clone HE 2. 1 458287 AA987556 Hs. 12867 ESTs 2. 1 423794 BE551781 Hs. 231895 ESTs 2. 1 408049 AW076098 Hs. 74316 desmoplakin (DPI, DPII) 2. 1 402721 2. 1 451999 AW176401 Hs. 27424 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2. 1 417541 Al992191 Hs. 180040 hypothetical protein FU22439 2. 1 414857 AW402389 Hs. 920 modulator recognition factor) 2. 1 435760 AF231922 Hs. 213004 chromosome 21 open reading frame 62 2. 1 428086 AL110193 Hs. 224137 hypothetical protein 2. 1 447853 Ai434204 Hs. 164285 ESTs, Weakly similar to AFG1 YEAST AFG1 2. 1 419034 NM 002110 Hs. 89555 hemopoieGc cell kinase 2. 1 431019 NM 005249 Hs. 2714 forkhead box G18 2. 1 421064 AI245432 Hs. 101382 tumor necrosis factor, alpha-induced pro 2. 1 416435 A1431301 Hs. 179703 KIAA0129 gene product 2. 1 437014 AA808757 Hs. 222531 ESTs, Weakly similar to S59501 interfero 2. 1 459369 T83080 gb : yd40eO3. r1 Soares fetal liver spleen 2. 1 402239 2. 1 412280 AW205116 Hs. 272814 hypothetical protein DKFZp434E1723 2. 1 426012 AA367507 Hs. 75874 pregnancy-associated plasma protein A 2. 1 438885 A1886558 Hs. 184987 ESTs 2. 1 426076 AW962714 gb : EST374787 MAGE resequences, MAGG Homo 2. 1 404561 2. 1 442932 AA457211 Hs. 8858 bromodomain adjacent to zinc finger doma 2. 1 408175 W29089 Hs. 19066 hypothetical protein DKFZp66702416 2. 1 423867 AA331886 gb : EST35757 Embryo, 8 week I Homo sapien 2. 1 458604 W37944 Hs. 4007 Sarcolemmal-associaled protein 2. 1 409650 T08490 Hs. 288969 HSCARG protein 2. 1 401729 2. 1 433675 AW977653 Hs. 75319 fibonucteotide reductase M2 polypepfide 2. 1 456741 W37608 Hs. 184492 ESTs 2. 1 417037 BE083936 Hs. 80976 antigen identified by monocbnalantibod 2. 1 415079 R43179 Hs. 22895 hypothetical protein FU23548 2. 1 439262 AA832333 Hs. 333045 ESTs 2. 1 403108 2. 1 436718 AW015227 Hs. 289053 hypothetical protein FU14733 2. 1 440696 At762757 Hs. 187660 putative Rab5 GDP/GTP exchange factor ho 2. 1

409745 AA077391 gb : 7B14E12 Chromosome 7 Fetal Brain cDNA 2. 1 453485 BE620712 Hs. 33026 hypothetical protein PP2447 2. 1 418177 N44967 Hs. 5663 ESTs 2. 1 457292 A1921270 Hs. 334882 hypothetical protein FLJ14251 2. 1 454434 AA083558 Hs. 261286 ESTs 2. 1 406085 2. 1 424441 X14850 Hs. 147097 H2Ahistonefamily memberX 2. 1 422726 U11690 Hs. 1572 faciogenital dysplasia (Aarskog-Scott sy 2. 1 424576 BE154142 Hs. 96833 ESTs 2. 1 423660 AL045228 Hs. 130831 Homo sapiens mRNA ; cDNA DKFZp434L137 (fr 2. 1 403509 AF231919 Hs. 18759 KIAA0539 gene product 2. 1 441940 AW298115 Hs. 128152 ESTs 2. 1 439190 AW978693 Hs. 293811 ESTs 2. 1 417791 AW965339 Hs. 111471 ESTs 2. 1 423701 AA329856 Hs. 143022 ESTs 2. 1 427239 BE270447 Hs. 174070 ubiquitin carder protein 2. 1 459642 BE243103 gb : TCAAP2E0949Pediathc acute myetogeno 2. 1 450385 AI631024 Hs. 24948 synuclein, alpha interacting protein (sy 2. 1 425159 NM 004341 Hs. 154868 carbamoyl-phosphate synthetase 2, aspart 2. 1 425591 AW294734 Hs. 279727 HomosapienscDNAFW14035hs cloneHE 2. 1 445101 T75202 Hs. 12314 Homo sapiens mRNA ; cDNA DKFZp586C1019 (f 2. 1 412811 H06382 Hs. 21400 ESTs 2. 1 426369 AF134157 Hs. 169487 Kreisler (mouse) maf-related leucine zip 2. 1 435924 AW029203 Hs. 191952 ESTs 2. 1 418388 R72332 Hs. 29258 Homo sapiens CDNA FU 11364 fis, clone HE 2. 1 452235 AL039743 Hs. 28514 testes development-related NYD-SP21 2. 1 452313 Y00486 Hs. 28914 adenine phosphoribosyltransferase 2. 1 450704 H85157 Hs. 40696 ESTs 2. 1 427539 AA405205 Hs. 97960 ESTs Weakly similar to T51146 dng-box 2. 1 402028 2. 1 405362 2. 1 414718 H95348 Hs. 107987 ESTs 2. 1 433424 R68252 Hs. 163566 ESTs 2. 1 444875 A1200759 Hs. 44737 ESTs 2. 0 449523 NM 000579 Hs. 54443 chemokinefC-C motif) receptor 5 2. 0 456072 H54381 gb : yq89aO3. s1 Soares fetal liver spleen 2. 0 436331 A1239495 Hs. 120189 ESTs 2. 0 448418 Z43704 Hs. 21192 Homo sapiens clone 25155 mRNA sequence 2. 0 447250 A1878909 Hs. 17883 protein phosphatase 16 (formerly 2C). ma 2. 0 448192 R43915 Hs. 4958 ESTs 2. 0 448966 AW372914 Hs. 86149 phosphoinosilol 3-phosphale-binding prol 2. 0 408605 AF025374 Hs. 46465 T-cell, immune regulator 1 2. 0 410790 AW803357 gb : IL2-UM0079-090300-050-A08 UM0079 Homo 2. 0 436872 X15624 gb : Human H1 RNA 2. 0 432238 AL133057 Hs. 274135 Homo sapiens mRNA ; cONA DKFZp434K1815 (f 2. 0 446307 T50083 Hs. 9094 ESTs 2. 0 436588 AA759233 Hs. 126506 ESTs 2. 0 452487 AW207659 Hs. 6630 Homo sapiens cDNA FW13329 hs clone OV 2. 0 430420 AW140027 Hs. 26373 Homo sapiens cDNA : FLJ23449 fis, clone H 2. 0 432036 AF224266 Hs. 272373 interleukin 20 2. 0 414460 L00727 Hs. 898 dystrophia myotonica-protein kinase 2. 0 433507 A1817336 Hs. 191791 ESTs 2. 0 427964 AA418082 Hs. 98286 ESTs Weakly similar to T20655 hypotheti 2. 0 443108 W86975 Hs. 203707 ESTs 2. 0 434504 A1887341 Hs. 121590 hypothetical protein FU12827 2. 0 454310 AW818390 Hs. 175613 homologofXenopusUaspin 2. 0 443566 A1290284 Hs. 159872 ESTs 2. 0 449722 BE280074 Hs. 23960 cyclin B1 2. 0 452682 AA456193 Hs. 9071 progesterone membrane binding protein 2. 0 412362 AW945484 Hs. 184252 ESTs Weakly similar to ALUB HUMAN ALU S 2. 0 429341 X73874 Hs. 2393 phosphorylase kinase, alpha 1 (muscle) 2. 0 435863 AF255346 Hs. 62919 Jun dimervabon prolein p21SNFT 2. 0 400774 R58624 Hs. 2186 eukaryo6c translation elongation factor 2. 0 453944 AW975369 Hs. 292570 Homosapiens cloneIMAGE : 3502107, MARNA, 2. 0 419227 BE537383 Hs. 89739 cholinergic receptor, nicotinic, beta po 2. 0 448529 T26460 Hs. 22550 ESTs 2. 0 443206 AB011420 Hs. 9075 serine/threonine kinase 17a (apoptosis-i 2. 0 439360 AA448488 Hs. 336629 dbosomal protein L44 2. 0 436660 A1658870 Hs. 184513 ESTs 2. 0 449030 AI365582 Hs. 57100 Homo sapiens mRNA for FW00016 protein, 2. 0 411048 AK001742 Hs. 67991 hypothetical protein DKFZp434G0522 2. 0 406624 AF052762 gb : Homosapiensclonecsneg8-1 immunoglo 2. 0 450666 T99968 Hs. 18799 ESTs Weakly similar to 138022 hypotheti 2. 0 446143 BE245342 Hs. 306079 sec61 homolog 2. 0 437698 R61837 Hs. 7990 ESTs Moderately similar to 184505 calci 2. 0 426607 AA382330 Hs. 124223 ESTs 2. 0 449246 AW411209 Hs. 23363 hypothetical protein FUI0983 2. 0 422564 A1148006 Hs. 222120 ESTs 2. 0 432682 A1376400 Hs. 159588 ESTs 2. 0 422140 BE295918 Hs. 112193 mutS (E. coli) homolog 5 2. 0 408215 BE614290 Hs. 43812 syntaxin 10 2. 0 417129 AH81800 Hs. 300684 calcitonin gene-related peptide-receptor 2. 0 442772 AW503680 Hs. 5957 Homo sapiens clone 24416 mRNA sequence 2. 0

434928 AW015595 Hs. 4267 Homo sapiens clones 24714 and 24715 mRNA 2. 0 411380 AW841619 gb : RC1-CN0017-120200-012-b09 CN001 Homo 2. 0 430603 AA148164 Hs. 247280 HBV associated faclor 2. 0 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring finge 2. 0 401125 2. 0 412939 AW411491 Hs. 2186 eukaryotic translation etongation factor 2. 0 448740 BE250632 Hs. 8026 sestrin 2 2. 0 454390 AB020713 Hs. 56966 KIAA0906 protein 2. 0 415012 NM_004383 Hs. 77793 c-src tyrosine kinase 2. 0 410407 X66839 Hs. 63287 carbonic anhydrase IX 2. 0 403478 2. 0 456485 Api393037 Hs. 97871 Homo sapiens, clone IMAGE : 3845253, mRNA, 2. 0 430294 A1538226 Hs. 32976 guanine nucleotide binding protein 4 2. 0 411669 BE612676 Hs. 303116 siromacell-derivedfælor2-likel 2. 0 451944 AW445218 Hs. 210876 ESTs 2. 0 436395 AJ227900 gb : Homo sapiens partial mRNA ; ID EE2-16B 2. 0 456457 AA252905 Hs. 194477 E3 ubiquitin ligase SMURF2 2. 0 449123 D50920 Hs. 23106 KIAA0130 gene product 2. 0 409214 AW405967 Hs. 333388 Homo sapiens, clone IMAGE : 3957135, mRNA, 2. 0 437619 AW351491 Hs. 334853 hypothetical protein FU23544 2. 0 453348 BE272318 Hs. 8595 hypothetical protein FU12438 2. 0 424382 AA351898 Hs. 23539 ESTs 2. 0 447079 AA280057 Hs. 105280 ESTs, Weakly similar to dJ963K23. 2 [H. sa 2. 0 449501 At652924 Hs. 231942 ESTs 2. 0 422893 X98411 Hs. 121555 myosin IF 2. 0 412125 Y17114 Hs. 73393 eyesabsent (Drosophila) homolog4 2. 0 434845 BE267057 Hs. 325321 hypothetica) protein R32184 1 2. 0 410422 AL042014 Hs. 334698 Homo sapiens, clone MGC : 15203, mRNA, com 2. 0 430255 AK000703 Hs. 323822 Homo sapiens mRNA for KIAA1551 protein, 2. 0 451656 BE327088 Hs. 212752 ESTs 2. 0 442068 BE312873 Hs. 314932 ESTs 2. 0 446846 AW197626 Hs. 271901 ESTs. Moderately similar to S08686 finge 2. 0 442690 A1014727 Hs. 160047 ESTs, Weakly similar to B28096 line-1 pr 2. 0 454277 AW295069 Hs. 31743 ESTs, Weakly similar to 1157 HUMAN ZINC 2. 0 426910 AA470023 Hs. 190089 ESTs, ModeralelysimilarloALU1_HUMANA 2. 0 402798 2. 0 404554 2. 0 TABLE 9B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 407909 1025254 1 AW103986 BE156395 BE156391 BE156190 BE156184 BE156388 BE156394 408432 1058667_1 AW195262 R27868 AW811262 409193 110747 1 AA131483 AA065156 AA076448 409745 115237 1 AA077391 AI347618 AI361453 A1088754 AW207491 AW960912 AA921874 AA286833 AA150722 BE152353 AW 188822 BE152450 410447 1203929-1 AW816134 BE063456 AW748795 BE150839 410790 1221131 1 AW803357 AW803423 AW812233 R06814 411256 1236790_1 AW834039 AW834040 AW834047 AW845410 BE003128 AW852479 411380 12423431 AW841619AW851958AW851851AW851985 411632 1252361_1 AW854829 AW854805 AW854841 AW854825 AW854822 AW854830 AW854835 AW854826 411658 1252987_1 AW855598 AW855608 BE148763 BE148764 AW855645 AW855615 AW855596 AW855610 AW855601 AW855605 411829 1260309_1 AW865749 BE179419 BE179492 412225 1284108_1 AW902042 N77591 412370 1291952 1 AW946614 AW946622 AW946663 AW946667 AW946615 AW946619 412391 1292625 1 AW947710 AW947698 AW947697 AW947713 413257 1355963 1 BE075035 BE074999 BE075006 BE075005 BE075032 BE075008 BE075037 413604 1379715_1 R51767 BE152515 Z44834 H23397 414406 1443333 1 BE297904 BE294312 414550 1460990-1 BE379808 415346 1534581 1 Z43108 F06295 R13085 415406 1536026 1 T26510 F07926 R53367 415586 1540116 1 Z45481 F12393 T74437 415635 1540853-1 F13168 R21289 T77628 416871 1626761 1 H98716 N90792 N24283 416913 163001 1 AW934714BE161007BE162500AW749902AW749864BE162498BE161005M190 449AW513465BE161006BE162499 417980 1712954_1 R32235 R32247 R32219 418333 173_2 W92113M702794 BE044316 W91984 AA679375 T94184 AA679335 BE503126 AW502118 BE467367 AA584550 AW139964 R93353 AW088477 A1887846 AW502624 W81697 W81696 AA447817 AA447667 F13631 AW268271 AA055366 AW629027 AA677404 AA831618 AI124782 AA889402 AA765804 AA765530 AA055698 AA594019 A1267368 AA456946 R93354 AF264624 AW668618 AA601493 418856 179649 1 AA362858 AW863761 AA229428 419217 182954J AA504571AA235243AA411737AW969068AA406543 419225 1830274-1 U70073 419311 1837931 AA689591 AW974261 AA236240 A1077451 AA631399 AW974262 420352 192979_1 BE256335 AW968316 M258918 AW843305 R14744 A1580388 BE07 1923 R36280 422128 211994 1 AW881145 AA490718 M85637 AA304575 T06067 AA331991 422156 212379_1 N34524 AA305071 AW954803 AA502335 A1433430 At203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512 Api334966 W32951 H62656 H53902 R88904 AW835732 422176 212714 1 H80977 BE147695 AA305496 AW962366 AA436754 423756 231725J AA828125AA834883AA330555 423867 232732 1 AA331886 AW962659 AW962655 T89841

425189 247825 1 H16622 R17322 AA351959 425517 252729 1 AF121179BE162736M353827 426076 260504 1 AW962714M369277M369278 426413 266650 1 AA377823 AW954494 A1022688 426503 268283 1 AA380153 AA380233 AW963529 426531 268760 1 AA381071 AA381084 AA380862 429875 310034 1 A1091815M460162M460761 430968 326269 1 AW972830 AA527647 AA489820 AA570362 432088 341195 1 AA525454 H74039 R89502 T77379 433532 368950 1 AW975367 AA598607 AA742735 434559 38889 1 AF147315 AW173079 T53029 435065 399329 1 BE064391 BE064395 AA663613 N99644 436190 41555 1 AK001059 AA633055 436395 41905 1 AJ227900 A1094933 AW051119 F00947 436532 421802 1 M721522 AW975443 T93070 436722 425758 1 AW975977 AA729469 AA747132 436872 42851-i X15624 437034 431713 1 AA742643 AA808575 AW976668 439086 46852 1 AF085947 H70981 H78989 439228 47001 1 N51700AF086051 N51792 439518 47334_1 W76326AF086341 W72300 439546 47360 1 AF088056 W76297 W72448 439566 47387 1 AF086387 W77884 W72711 439710 47550_1 AF086543W96291 W96225 443657 576685_1 R14973R14967AI081006 444168 593829 1 AW379879 A1126285 H12014 444386 604004 1 BE065183 A1144398 BE065367 451129 859870 1 BE072881 BE072946 A1762181 452712 928309_1 AW8386 16 AW838660 BE144343 Al914520 AW888910 BE164854 BE184784 453446 967533 1 BE299996 BE297115 BE270415 BE295214 BE296526 453638 975649_1 AW814996AL047199AW850979 453746 979731 1 AL120611 BE006190BE006189 454377 114761 1 AA076811 AW814764 454389 115682 1 AW752571 AW847602 AA077979 454606 1226149 2 AW809752 AW810271 AW809944 AW810319 AW810215 AW810368 AW810167 454630 1227352 1 BE142075 BE142148 BE142189AW816249 BE142147 BE142002 BE142406 BE142094 BE142020 BE142074 BE142347 BE142000 BE142375 AW811189 BE142133 454631 1227443 1 AW811324 AW811325 AW811326 AW811333 AW811329 AW811328 AW811332 AW811339 AW811335 454679 1228929 AW813110AW813113 454967 1247021 1 AW848276 AW848416 AW848160 AW847945 AW847947 AW848063 AW848113 455023 1249183_1 AW850907 AW850901 AW850877 455302 1276542 1 AW997641 AW891777 455470 1292849 1 AW947992 AW947967 AW947950 AW947957 AW947953 AW947973 AW947966 AW947971 AW947947 AW947970 AW947995 AW947979 AW947952 AW947956 455514 1321649 1 AW983871 BE090302 AW983867 AW983845 AW983860 AW983853 AW983852 455530 1322298_1 AW984744 AW984759 455584 1334741 1 BE007420 BE007419 BE007421 BE007422 455778 1364506 1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 455908 1382301 1 BE156306 BE156183 BE156298 BE156377 BE156374 456072 1470256 1 H54381 H54463 BE393262 456094 1504780 1 H95091 C01228 457374 328758-1 AA493662 AW897396 BE 154814 457578 359618-1 AA578027 457730 393905-1 AW753613AW753857 BE150374 BE150693 BE150394AA808851 AA650159AA654653 BE150419 TABLE 9C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et a. refers lo the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposi60n : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 400822 7465000 Plus 186223-186402, 186878-187275 400859 9757499 Minus 91888-92018. 98131-98294, 99474-99570 400917 7283186 Minus 173258-173631 400992 8096828 Plus 140390-140822 401012 7230838 Minus 736-1137 401048 7232177 Plus 132430-132761 401125 8570296 Minus 126863-126984 401324 9863791 Plus 234057-234174 401384 6850939 Minus 58360-58545 401558 7139678 Plus 103510-104090 401626 8575943 Minus 238100-238432 401676 9965536 Plus 3891-4691 401714 6715702 Plus 96484-96681 401729 8134856 Minus 90651-90878 401827 2262095 Plus 94725-94860, 98452-98660 401876 8099107 Plus 95913-96641 402028 7139781 Plus 8874g89237 402064 8117294 Plus 100159-100350, 100445-100912 402239 7690131 Plus 38175-38304, 42133-42266 402408 9796239 Minus 110326110491

402424 9796344 Minus 64925-65073 402516 9798099 Minus 195342-195511 402604 9909420 Plus 20393-20767 402627 9931216 Plus 12136-12272, 16487-16628, 17654-17798, 18494-18621, 18933-9089, 20669-20790, 21134-21298, 22866-22973, 23686-23820, 26626- 26895, 29279-29469 402721 8969253 Minus 144428-144715 402798 3355547 Plus 23596-23867 402856 9801288 Minus 90119-90411 403048 4210991 Plus 4427544592, 49656-49955 403108 8980955 Plus 93253-93667 403142 9444521 Plus 89286-90131 403166 9838127 Minus 67762-67940. 68695-68856, 70394-70507 403478 9958258 Plus 116458-116564 403680 7331517 Minus 157184-157415 403751 7229815 Minus 158794-160929 403790 8084957 Minus 87826-87947, 89835-90002 403797 8099896 Minus 123065-125008 403857 7708910 Minus 2524-3408 403881 7710245 Minus 107250-107685, 108924-109213 403961 7596976 Minus 110393-110603 403969 8569909 Plus 31237-31375, 32405-32506 404020 8655966 Minus 174449-174663 404054 3548785 Plus 66713-69175 404084 9944055 Plus 2795-2969 404108 8247074 Minus 63603-64942 404170 9930793 Plus 168836-169248 404185 4572584 Minus 129171-129327 404240 5002624 Minus 116132-116407, 116653-116922 404295 9856663 Minus 75747-75947 404299 5738652 Minus 3826-4025 404366 9964977 Plus 96589-96801 404554 7243881 Plus 42637-42839 404561 9795980 Minus 69039-70100 404584 9857511 Plus 138651-139153 404589 9931665 Minus 32824-32985 404642 9796810 Plus 102999-103145 404652 9796969 Minus 108172-108296 404721 9856648 Minus 173763-174294 404756 7706327 Plus 82849-83627 404802 4581357 Minus 30093-30600 404984 6939882 Plus 87221-87505 405159 9966252 Plus 79659-79804 405258 7329310 Plus 129930-130076 405288 6139075 Minus 126268-126436 405353 2811095 Plus 118525-118892 405362 2337862 Minus 105008-105142. 105980-106091. 140445-140556, 142519-142641 405558 1621110 Plus 4502-4644, 5983-6083 405588 5002511 Plus 46180-46366 405605 5836195 Minus 117070-117270 405701 4263751 Plus 93243-93364 405741 9966947 Minus 156747-156875, 156936-157208 405747 8469069 Minus 153933-154060 405771 7018349 Plus 91191-91254, 91510-91589 405808 9929207 Plus 10975&111166 405884 6758747 Plus 62383-62583 405915 7712162 Minus 43717-43859 406028 8312303 Minus 177469-177829 406085 9123888 Plus 18665-18843 406169 6684220 Minus 12620-14251 406267 7528342 Minus 2570-2731 406326 9212385 Plus 84508-84655 406347 9255981 Plus 90900-91091 406474 9795567 Plus 52758-53211 406577 7711730 Plus 11377-11509 406610 8312226 Plus 13096-13334 TABLE 10A : ABOUT 582 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES Table 10A lists about 582 genes significantly down-regulated in glioblastoma compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to'average'glioblastoma was greater than or equal to 3. The'average'normal CNS level was set to the 75th pereentiie amongst various normal CNS tissues. The'average'glioblastoma level was set to the 85th percentage amongst various tumor samples. In order to remove gene-specific background levels of non-specific hybridization, the 10th percent value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tide : Unigene gene tique R1 : Ratio of 75th percen6le normal central nervous system tissue to 85th percen6le tumor Pkey ExAccn UnigenelD Unigene Title R1 453655 AW960427 Hs. 79059 transforming growth factor, beta recepto 136. 7 417275 X63578 Hs. 295449 parvalbumin 29. 0 430829 AW451999 Hs. 194024 ESTs 25. 7

410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 22. 6 419954 D14720 Hs. 93883 myelin protein zero (Charcot-Marie-Tooth 21. 2 459247 N46243 Hs. 110373 ESTs, Highly similar to T42626 secreted 18. 5 416133 NM 001683 Hs. 89512 ATPase, Ca-transporting, plasma membra 15. 5 416018 AW138239 Hs. 78977 proprotein convertase subtilisinlkexin t 15. 2 417167 AW206437 Hs. 4290 ESTs 14. 8 433940 H05129 Hs. 7459 cyclic AMP-regulated phosphoprotein, 21 13. 4 413324 V00571 Hs. 75294 corticotropin releasing hormone 13. 1 439830 AA846666 Hs. 151489 ESTs, Weakly similar to XE7_HUMAN PROTEI 12. 6 408068 AW148652 Hs. 167398 ESTs 12. 6 412636 NM 004415 Hs. 74316 desmoplakin (DPI, DPII) 12. 5 429096 AB011106 Hs. 196012 KIAA0534 protein 12. 2 412638 AA910199 Hs. 203838 ESTs 12. 2 423690 AA329648 Hs. 23804 ESTs, Weakly similar to PN0099 son3 prot 12. 1 456844 Al264155 Hs. 152981 CDP-diacylglycerol synthase (phosphatida 11. 9 418318 U47732 Hs. 84072 transmembrane 4 superfamily member 3 10. 9 442593 R39804 Hs. 31961 ESTs 10. 8 446353 A1290919 Hs. 153661 ESTs 10. 4 420290 AW977318 Hs. 194480 ESTs 10. 3 414220 BE298094 gb : 601118231Fi NIH_MGC_i7 Homo sapiens c 10. 3 414290 A1568801 Hs. 71721 ESTs 10. 2 426365 AA376667 Hs. 10283 RNA binding motif protein 8B 10. 0 414937 R38698 Hs. 12382 ESTs 10. 0 419643 F06066 Hs. 91791 chromosome 11 open reading frame 25 9. 5 407173 T64349 gb : yclOdO8. s1 Stratagene lung (937210) H 9. 5 412454 R55745 Hs. 167330 ESTs 9. 5 439366 AF100143 Hs. 6540 fibroblast growth factor 13 9. 4 415315 F12240 Hs. 250655 prothymosin, alpha (gene sequence 28) 9. 3 441790 AW294909 Hs. 132208 ESTs 9. 2 448117 H49129 Hs. 172982 ESTs 9. 1 400661 9. 0 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheG 9. 0 412453 R20205 Hs. 167330 ESTs 9. 0 408920 AL120071 Hs. 48998 fibronectin leucine rich transmembrane p 8. 9 409031 AA376836 Hs. 76728 ESTs 8. 7 428106 BE620016 Hs. 182470 PTD010 protein 8. 3 446544 Al631932 Hs. 7047 ESTs, Weakly similar to Unknown (H. sapie 8. 2 423479 NM 014326 Hs. 129208 death-associated protein kinase 2 8. 2 439480 AL038511 Hs. 125316 ESTs, Weakly similar to S33990 finger pr 8. 2 418036 Z37976 Hs. 83337 latent transforming growth factor beta b 8. 0 456490 U83171 Hs. 97203 small inducible cytokine subfamily A (Cy 8. 0 410200 AA082557 Hs. 101915 Stargardt disease 3 (autosomal dominant) S. 0 414602 AW630088 Hs. 76550 Homo sapiens mRNA ; cDNADKFZp564B1264 (f 8. 0 408428 NM014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 7. 9 437073 A1885608 Hs. 94122 ESTs 7. 9 408434 AW195317 Hs. 107716 hypothetical protein FU22344 7. 9 438150 AA037534 Hs. 79059 transforming growth factor, beta recepto 7. 9 440209 H05049 Hs. 22269 neurexin 3 7. 8 408119 W26213 Hs. 101672 ESTs, Weakly similar lo T00331 hypolheli 7. 8 417421 AL138201 Hs. 82120 nuclear receptor subfamily 4, group A, m 7. 8 410587 AA370706 Hs. 86412 chromosome 9 open reading frame 5 7. 8 429611 AI889077 Hs. 211388 HomosapiensBACcloneCTB-60N22from7q 7. 7 405800 7. 7 421750 AK000768 Hs. 107872 hypothetical protein FLJ20761 7. 7 426356 BE536836 Hs. 98682 hypothetical protein FKSG32 7. 7 423440 R25234 Hs. 143434 contacfin 1 7. 7 445148 A1214510 Hs. 146304 ESTs 7. 6 416294 D86980 Hs. 79170 KIAA0227 protein 7. 6 424087 N69333 Hs. 143434 contact 1 7. 6 437479 R61866 Hs. 101277 ESTs 7. 5 405071 7. 5 421224 AW402154 Hs. 125812 ESTs 7. 4 442025 AW887434 Hs. 11810 CDA11 protein 7. 4 459476 BE185844 gb : lL5-HT0731-110500087-cO3HT0731 Homo 7. 2 430573 AA744550 Hs. 136345 ESTs 7. 1 401836 7. 1 448958 AB020651 Hs. 22653 KIAA0844 protein 7. 1 430152 AB001325 Hs. 234642 aquaporin 3 7. 1 419474 AW968619 Hs. 155849 ESTs 7. 1 401780 7. 1 446052 AA358760 gb : EST67699 Fetal lung 11 Homo sapiens c 7. 0 423605 AF047826 Hs. 129887 cadherin 19, Iype 2 7. 0 433098 AW190593 Hs. 151143 ESTs 7. 0 449511 A1436187 Hs. 296261 guanine nucleotide binding protein (G pr 6. 9 451285 AW137912 Hs. 227583 Homo sapiens chromosome X map Xp11. 23 L-6. 8 428414 AL049980 Hs. 184216 DKFZP564C152 protein 6. 8 419273 BE271180 Hs. 293490 ESTs, Weakly similar to 138022 hypolhe6 6. 8 443155 R54485 Hs. 23772 ESTs 6. 8 450561 R49674 Hs. 25909 ESTs 6. 8 433068 Nom-006456 Hs. 288215 sialyltransterase 6. 8 440729 AA904739 Hs. 128204 ESTs 6. 8 448426 BE018315 Hs. 280776 tankyrase, TRF1-interacting ankyrin-rela 6. 7 423589 AA328082 Hs. 209569 ESTs 6. 6

415681 A1379882 Hs. 72630 ESTs 6. 5 413510 F13044 gb : HSC3HH101 normalized infant brain cDN 6. 4 427992 Y15014 Hs. 181353 UDP-Gal : betaGIcNAc beta 1, 3-galactosyiV 6. 4 453344 BE349075 Hs. 44571 ESTs 6. 4 450642 R39773 Hs. 7130 copine IV 6. 4 432251 AW972983 Hs. 232165 polycythemiarubravera1 ; cellsurfæe 6. 4 429322 D86984 Hs. 199243 KIAA0231 protein 6. 4 444927 AW016637 Hs. 199425 ESTs 6. 4 447482 AB033059 Hs. 18705 KIAA1233 protein 6. 4 400332 S66407 Hs. 248032 FLT4 6. 3 440703 AL137663 Hs. 7378 Homo sapiens mRNA ; cDNA DKFZp434G227 (fr 6. 3 446129 AW244073 Hs. 145946 ESTs 6. 3 454076 AW204712 Hs. 61957 ESTs 6. 3 425526 M359933 gob : EST69040 Fetal lung 11 Homo sapiens c 6. 3 421913 A1934365 Hs. 109439 osteoglycin (osteoinducuve factor, mime 6. 3 434273 AA913143 Hs. 26303 ESTs 6. 2 408480 A (350337 Hs. 164568 fibroblast growth factor 7 (keragnocyte 6. 2 451301 A1769514 Hs. 209890 EST 6. 2 430754 AW862610 Hs. 157068 ESTs 6. 2 438356 AA805530 Hs. 48527 ESTs 6. 2 422743 BE304678 Hs. 119598 hbosoma ! protein L3 6. 2 453355 AW295374 Hs. 31412 Homo sapiens DNA 1422 fis. done HE 6. 2 426388 AW081394 Hs. 97103 ESTs 6. 2 452502 AI904296 gb : PM-BT046-220199-2861BT046Homosapi 6. 1 402546. 6. 1 457534 Al761307 Hs. 232226 ESTs 6. 1 408165 AL137573 Hs. 43143 Homo sapiens mRNA ; cDNA DKFZp564A2463 (f 6. 1 404958 6. 1 432501 BE546532 Hs. 25682 Homo sapiens mRNA for KIAA1863 protein, 6. 1 442979 AW440782 Hs. 174743 ESTs 6. 1 422262 AL022315 Hs. 113987 lecUn, galactoside-binding, soluble, 2 6. 0 408713 NM 001248 Hs. 47042 ectonucleoside triphosphate diphosphohyd 6. 0 454065 BE394588 gb : 601311808F1NIH MGC_44Homosapiensc 6. 0 430004 U27768 Hs. 227571 regulator of G-protein signalling 4 5. 9 401521 5. 9 425087 R62424 Hs. 126059 ESTs 5. 9 446298 AF187813 Hs. 14637 kidney-and liver-specific gene 5. 9 417761 R13727 Hs. 21435 ESTs 5. 9 424806 AA382523 Hs. 105689 MSTP031 protein 5. 9 441695 T12411 Hs. 183745 hypothetical protein FLJ13456 5. 9 457483 AB034694 Hs. 272558 endomucin-1 5. 9 417175 R44558 Hs. 94002 ESTs 5. 8 437483 AL390174 gb : Homo sapiens mRNA ; cDNA DKFZp547J184 5. 8 436427 A1344378 Hs. 143399 ESTs 5. 8 411939 A1365585 Hs. 146246 ESTs 5. 8 459053 A1807052 Hs. 210361 ESTs 5. 7 411052 AW814950 gb : MR1-ST0206-130400-023-d06ST0206Homo 5. 7 431063 Z98949 Hs. 326843 hypothetical protein bk125H2. 1 5. 7 450382 AA397658 Hs. 60257 Homo sapiens CDNA FU 13598 fis, clone PL 5. 7 408478 NM000806 Hs. 45740 gamma-aminobutyric acid (GABA) A recepto 5. 7 442676 A1733585 Hs. 130897 ESTs 5. 7 446443 AV659082 Hs. 134228 ESTs 5. 7 400865 5. 7 459080 AW192083 Hs. 290855 ESTs 5. 6 407952 A1215902 Hs. 88845 ESTs, Highly similar to T50835 hypotheti 5. 6 431984 AL080239 Hs. 272284 Human DNA sequence from clone GS1-256022 5. 6 425705 AF007833 Hs. 159265 kruppel-relaledzinc6ngerproleinhcKr 5. 6 442238 AW135374 Hs. 270949 ESTs, Moderately similar to F41925 hypot 5. 6 422994 AW891802 Hs. 296276 ESTs 5. 6 457148 AF091035 Hs. 184627 KlM0118prolein 5. 6 428356 AL046991 Hs. 10338 ESTs 5. 6 415927 AL120168 Hs. 78919 Kell blood group precursor (McLeod pheno 5. 5 402092 5. 5 440526 A1832243 Hs. 211471 ESTs 5. 5 444409 A1792140 Hs. 49265 ESTs 5. 5 417877 A1025829 Hs. 86320 ESTs 5. 4 458238 AW071521 Hs. 333541 beta-amyloid binding protein precursor 5. 4 430702 U56979 Hs. 250651 H factor 1 (complement) 5. 4 456189 H91010 Hs. 44940 ESTs 5. 4 427424 AA402453 Hs. 113011 ESTs 5. 4 437354 AA749215 Hs. 291886 ESTs 5. 4 455617 BE078070 gb : CM1-BT0614-160300-149-fO2 BT0614 Homo 5. 4 429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 5. 3 427861 AA813185 Hs. 98183 ESTs 5. 3 408556 U49516 Hs. 46362 5-hydroxytryptamine (serotonin) receptor 5. 3 444209 A1753134 Hs. 146494 ESTs 5. 3 422831 R02504 Hs. 332943 ESTs 5. 3 403180 5. 3 418026 BE379727 Hs. 83213 fatty acid binding protein 4, adipocyte 5. 3 430339 W28608 Hs. 239625 integral membrane protein 2B 5. 2 431596 T34708 Hs. 272927 Sec23 (S. cerevisiae) homolog A 5. 2 431930 AB035301 Hs. 272211 cadherin 7, lype 2 5. 2 437403 A1208149 Hs. 121196 ESTs 5. 2

438285 AA782845 Hs. 22790 ESTs 5. 2 439901 N73885 Hs. 124169 ESTs 5. 2 438507 AA809052 Hs. 211275 ESTs 5. 2 449222 AW293984 Hs. 197621 ESTs 5. 2 402834 AK001507 Hs. 306084 Homo sapiens clone FLB6914 PR01821 mRNA, 5. 2 419042 T81429 Hs. 221065 ESTs 5. 2 436777 AA731199 Hs. 293130 ESTs 5. 2 445071 A1280246 Hs. 149504 ESTs 5. 1 408016 AW136827 Hs. 256096 ESTs 5. 1 412047 AA934589 Hs. 49696 ESTs 5. 1 436953 AW959074 Hs. 23648 Homo sapiens cDNA FLJ 13097 fis, clone NT 5. 1 436773 AW078629 Hs. 82110 PC4 and SFRS1 interacting protein ! 5. 1 409263 AA069573 Hs. 50319 ESTs 5. 1 453830 AA534296 Hs. 20953 ESTs 5. 1 459580 AA022888 Hs. 176065 ESTs 5. 1 417616 R07728 Hs. 268668 ESTs 5. 1 423457 F08208 Hs. 283844 similar to rat Ncarboxylate carcier-li 5. 1 441535 AL135735 Hs. 7885 phosphatidylinositol binding clathrin as 5. 0 416490 AF090116 Hs. 79348 regulator of G-protein signalling 7 5. 0 417284 N62889 Hs. 107242 Homo sapiens cDNA FU12965 fis, clone NT 5. 0 447135 T58148 gb : yb98gO6. s1 Stratagene lung (937210) H 5. 0 448605 AL109678 Hs. 21597 Homo sapiens mRNA hull lenglh inseri cDN 5. 0 442240 A1791883 Hs. 292719 ESTs 4. 9 459399 BE407712 Hs. 153998 creatinekinase. mitochondna) 1 (ubiqui 4. 9 427972 AA864870 Hs. 181304 putative gene product 4. 9 432944 AA570687 Hs. 38512 ESTs 4. 9 440198 BE560093 gb : 601345159F1 NIH_MGC_8 Homo sapiens cD 4. 9 444047 A1097452 Hs. 135095 ESTs 4. 9 416040 AW819158 Hs. 289044 Homo sapiens cDNA FU12048 fis, clone HE 4. 9 444922 AI921750 Hs. 144871 Homo sapiens cDNA FU 13752 fis, clone PL 4. 8 436670 A1690021 Hs. 201536 ESTs 4. 8 448072 A1459306 Hs. 24908 ESTs 4. 8 408936 AL138043 Hs. 293549 ESTs 4. 8 412622 AW664708 Hs. 171959 ESTs 4. 8 414943 D80647 Hs. 124193 ESTs 4. 8 429254 H10133 Hs. 91846 hypothetical protein DKFZp761C121 4. 8 453567 A1742835 Hs. 33368 hypothetical protein FLJ 11175 4. 8 407906 AA369665 Hs. 41185 Homo sapiens mRNA : cDNA DKFZp56401262 (f 4. 8 441028 AI333660 Hs. 17558 Homo sapiens cDNA FW14446 hs, clone HE 4. 7 405130 4. 7 455225 AW996689 gb : QV3-BN0046-150400-151-g098N0046Homo 4. 7 446218 AV657159 gb : AV657159 GLC Homo sapiens cDNA clone 4. 7 443347 A1052543 Hs. 133244 melanoma-derived leucine zipper, extra-n 4. 7 402176 4. 7 416577 BE063207 Hs. 79381 grancalcin 4 7 436221 AK001781 Hs. 296543 HomosapienscDNAFW10919hs, cloneOV 4. 7 420480 AL137361 Hs. 98173 hypothetical protein 4. 7 400800 Y10262 Hs. 46925 eyes absent (Drosophila) homolog 3 4. 6 435161 AF124150 Hs. 272091 ESTs 4. 6 404793 4. 6 430895 U66581 Hs. 248121 G protein-coupled receptor 22 4. 6 438571 AW020775 Hs. 56022 ESTs 4. 6 445924 A1264671 Hs. 164166 ESTs 4, 6 444585 AW170015 Hs. 6594 ESTs 4. 6 421044 AF061871 Hs. 311736 HumanDNAsequencefromcloneRP1-238D15 4. 6 418274 A1458587 Hs. 128677 HumanDNAsequencefromcloneRP1-50024 4. 6 425475 W56339 Hs. 107057 ESTs 4. 6 434311 BE543469 Hs. 266263 Homo sapiens CDNA FU14115 fis, clone MA 4. 5 414272 Al651603 Hs. 46988 ESTs 4. 5 445235 A1564022 Hs. 138207 ESTs 4. 5 414327 BE408145 Hs. 185254 ESTs, Weakly similar to T24435 hypotheti 4. 5 414630 BE410857 gb : 601301177F1 NIH MGC 21 Homosapiensc 4. 5 414456 H74314 gb : yuS6e10. r1 Soaresfetalliverspleen 4. 5 401024 4. 5 414699 Al815523 Hs. 76930 synuclein, alpha (non A4 component of am 4. 5 423449 A1497900 Hs. 33067 ESTs 4. 5 405138 4. 5 413544 BE147225 gb : PM2-HT0225-031299-003-f11 HT0225Homo 4. 5 453880 A1803166 Hs. 28462 ESTs, Weakly similar to 138022 hypotheti 4. 5 433521 T66087 Hs. 112482 Homo sapiens unknown mRNA sequence 4. 4 441184 AA922009 Hs. 150269 ESTs 4. 4 429876 AB028977 Hs. 225974 KIAA1054 protein 4. 4 445481 AW661846 Hs. 148836 ESTs 4. 4 452340 NM002202 Hs. 505 ISL1 transcription factor, LIM/homeodoma 4. 4 404769 4. 4 444331 AW193342 Hs. 24144 ESTs 4. 4 429726 AW628326 Hs. 27151 ESTs 4. 4 449093 AB035356 Hs. 22998 neurexin 1 4. 4 451959 AA056203 Hs. 27337 hypotheticaiprotein FLJ20623 4. 4 415716 N59294 Hs. 179662 nucleosome assembly protein 1-like 1 4. 4 417888 R23053 gb : yh31a05. r1 Scares placenta Nb2HP Homo 4. 4 419656 AB002314 Hs. 92025 KIAA0316 gene product 4. 4 425864 U56420 Hs. 159903 olfactory receptor, family 5, subfamily 4. 4

435078 AW518888 Hs. 40937 ESTs 4 4 413493 BE144444 gb : MRO-HT0168-141199-002-f09HT0168Homo 4. 3 432712 AB016247 Hs. 288031 sterol-C5-desaturase (fungal ERG3, delta 4. 3 459650 R25754 Hs. 301185 ESTs 4 3 404828 4. 3 423782 A1472209 Hs. 323117 ESTs 4 3 426867 AA460967 Hs. 22668 ESTs 4. 3 426802 AA385182 Hs. 46699 ESTs 4. 3 457353 X65633 Hs. 248144 melanocortin 2 receptor (adrenocorticotr 4. 3 412112 BE180342 gb : RC3-HT0622-130400-012-aO7HT0622Homo 4. 3 401522 N47812 Hs. 306198 CGI-35 protein 4. 3 419055 Api365384 Hs. 11571 Homo sapiens cDNA FLJ11570 fis, clone HE 4. 3 410171 H07892 Hs. 12431 ESTs 4. 3 419564 U08989 Hs. 91139 solulecanierfamily1 (neunona/epiUhe 4. 3 458789 AL157468 Hs. 325825 Homo sapiens cDNA FW20848 hs, cbne AD 4. 3 455040 AW852286 gb : OVO-CT0225-100400-187-dO8 CT0225 Homo 4. 3 438533 Al440266 Hs. 170673 ESTs, Weakly similar to T24832 hypothefi 4. 3 459005 AA447679 Hs. 144558 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 2 418489 U76421 Hs. 85302 adenosinedeaminase, RNA-speciEc, B1 (h 4. 2 433389 AF038171 gb : Homo sapiens clone 23671 mRNA sequenc 4. 2 454356 AW390363 Hs. 11522 hypolhe6calproleinfromXq28 4. 2 442339 BE299668 Hs. 227591 ESTs, Weakly similar to 1901303A Leu zip 4. 2 421249 AA285362 gb : HTH277HTCDL1 HomosapienscDNA5ß 4. 2 443998 A1620661 Hs. 296276 ESTs 4. 2 452197 AW023595 Hs. 232048 ESTs 4. 2 451117 AA015752 Hs. 205173 ESTs 4. 2 404501 AW247252 Hs. 75514 nucleoside phosphorylase 4. 2 410378 R23324 Hs. 41693 DnaJ (Hsp40) homolog, subfamily B, membe 4. 2 422528 AB011182 Hs. 118087 KIAA0610 protein 4. 2 440323 AA970614 Hs. 127992 ESTs 4. 1 425767 AF054176 Hs. 159483 chromosome 1 open reading frame 7 4. 1 434460 AA478486 Hs. 3852 KIAA0368 protein 4. 1 410362 H04811 Hs. 93164 proprolein convertase subtilisinlkexin t 4. 1 413121 T96090 Hs. 142678 ESTs 4. 1 409403 AA668224 Hs. 6634 Homo sapiens cDNA : FLJ22547 fis, clone H 4. 1 450235 AA007512 Hs. 17538 ESTs 4. 1 449754 H00820 Hs. 30977 ESTs, Weakly similar to B34087 hypotheb 4. 1 421813 BE048255 gb : lz49bO5. y1 NCl_CGAP_BmS2Homosapien 41 408496 A1683802 Hs. 136182 ESTs 4. 1 430261 AA305127 Hs. 237225 hypothetical protein HT023 4. 1 434101 AA625205 Hs. 259599 KIAA1622 protein 4. 1 451837 T92157 Hs. 16970 ESTs 4. 1 411772 BE170301 gb : QV4-HT0536-040500-193-fO5 HT0536 Homo 4. 1 437630 A1252782 Hs. 153026 SWAP-70 protein 4. 1 430212 AA469153 gb : nc67fO4. s1 NCI_CGAP_Pr1 Homo sapiens 4. 0 400216 40 429830 A1537278 Hs. 225841 DKFZP434D193 prolein 4. 0 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 4. 0 418047 R37633 Hs. 4847 ESTs 4. 0 405354 4. 0 427931 AW206512 Hs. 186996 ESTs 4. 0 428775 AA434579 Hs. 143691 ESTs 4. 0 449422 AA001373 Hs. 59821 ESTs 4. 0 453864 AW021407 Hs. 21068 hypothetical protein 4. 0 456407 AW968614 gb : EST380690 MAGE resequences, MAGJ Homo 4. 0 441869 Nom003947 Hs. 8004 huntingtin-associated protein interacbn 4. 0 420784 T65158 Hs. 102399 ESTs, Moderately similar to S65657 alpha 4. 0 425195 AA352026 Hs. 94319 VPS10 domain receptor protein 4. 0 429628 H09604 Hs. 13268 ESTs 4. 0 410087 F12079 Hs. 332579 ESTs 4. 0 409840 AW502122 gb : UI-HF-BROp-ajrc-08-0-Ul. r1 NIH_MGC_5 4. 0 452854 AA437061 Hs. 14060 prokineticint precursor 4. 0 419910 AA662913 Hs. 190173 ESTs, Weakly similar to A46010 X-linked 4. 0 427443 AA402713 Hs. 97872 ESTs 4. 0 414990 C17758 Hs. 221652 Homo sapiens cDNA FU 14323 fis, clone PL 3. 9 412678 AA115575 Hs. 114914 ESTs 3. 9 405629 3. 9 420299 A1056871 Hs. 15276 ESTs 3. 9 453098 Z25935 Hs. 86379 ESTs 3. 9 435752 AF230801 gb : Homo sapiens growth hormone receptor 3. 9 441005 Z41305 Hs. 303172 Homo sapiens mRNA ; cDNADKFZp547G133 (fr 3. 9 414516 A1307802 Hs. 135560 ESTs, Weakly similar to T43458 hypotheti 3. 9 442257 AW503831 Hs. 323370 Human EST clone 25267 mariner transposon 3. 9 422563 BE299342 Hs. 19348 hypothetical protein FU13119 3. 9 406697 M21388 Hs. 123017 Human unproducbvely rearranged Ig mu-ch 3. 9 443850 AW014723 Hs. 334612 ESTs 3. 9 412677 AW029608 Hs. 17384 ESTs 3. 9 422788 AL117352 Hs. 120828 HumanDNAsequencehomcloneRP5876B10 3. 9 405377 3. 9 414376 BE393856 Hs. 66915 ESTs. Weakly similar to 16. 7Kd protein 3. 9 453341 Api758912 Hs. 296341 adenylyl cyclase-associated protein 2 3. 9 431960 AW241821 Hs. 301927 c6. lA 3. 9 416854 H40164 Hs. 80296 Purkinje cell protein 4 3. 9

427264 AA400117 Hs. 125747 ESTs 3. 9 422746 Nom 004484 Hs. 119651 glypican 3 3. 9 452346 BE243534 gb : TCBAP1D0885 Pediatric pre-B cell acut 3. 9 414666 Nom-004466 Hs. 76828 glypican 5 3. 8 418217 A1910647 Hs. 13442 ESTs 3. 8 419118 AA234223 Hs. 139204 ESTs 3. 8 445017 A1205493 Hs. 176860 ESTs 3. 8 405667 3. 8 422760 BE409561 gb : 601299865F1 NIH_MGC_21 Homosapiensc 3. 8 453863 X02544 Hs. 572 orosomucoid 1 3. 8 457821 H47166 Hs. 124322 ESTs Weakly similar to A47582 Bceli gr 3. 8 457330 AB013818 Hs. 247220 peroxisome biogenesis factor 10 3. 8 435600 AL047034 Hs. 119747 ESTs 3. 8 456083 U46922 Hs. 77252 fragile histidine triad gene 3. 8 413341 H78472 Hs. 191325 ESTs Weakly similar to Ti 8967 hypothefi 3. 8 449057 AB037784 Hs. 22941 KIAA1363 protein 3. 8 421855 F06504 Hs. 27384 ESTs Moderately similar to ALU4_HUMAN A 3. 8 414764 AW013887 Hs. 72047 ESTs 3. 8 404391 3. 7 433629 R13140 Hs. 13359 ESTs 3. 7 424738 A1963740 Hs. 46826 ESTs 3. 7 401315 3. 7 407706 AA191085 Hs. 26612 ESTs Moderately similar to S23650 retro 3. 7 440530 AA888646 Hs. 174187 ESTs 3. 7 433930 AA620338 Hs. 273781 ESTs 3. 7 409662 AW452320 Hs. 279726 ESTs 3. 7 437268 AI754847 Hs. 227571 regulator of G-protein signalling 4 3. 7 445688 Al248205 Hs. 153244 ESTs 3. 7 408593 R19566 Hs. 197617 ESTs 3. 7 417091 AA193283 Hs. 291990 ESTs 3. 7 448556 AW885606 Hs. 5064 ESTs 3. 7 423135 N67655 Hs. 26411 ESTs 3. 7 400135 3. 7 459150 BE155356 gb : PM1-HT0350-160300-OOgdO6 HT0350 Homo 3. 7 457221 AW383197 Hs. 218260 ESTs 3. 7 451660 A1807927 Hs. 249601 ESTs 3. 7 401600 BE247275 Hs. 151787 U5 snRNP-specific protein, 116 kD 3. 7 446818 A1342668 Hs. 279765 ESTs 3. 7 447795 AW295151 Hs. 163612 ESTs 3. 7 427562 R56424 Hs. 26534 ESTs 3. 6 412258 AA376768 Hs. 324841 hypothetical protein FU22622 3. 6 454339 AW381980 gb : QV4-HT0316-091199-028-d05HT0316Homo 3. 6 439274 AF086092 Hs. 48372 ESTs 3. 6 452381 H23329 Hs. 290880 ESTs Weakly similar to ALU 1 _HUMAN ALU S 3. 6 422897 AA679784 Hs. 4290 ESTs 3. 6 429656 X05608 Hs. 211584 neurofilament, light potypeptide (68kD) 3. 6 421908 AW935200 Hs. 285814 sprouty (Drosophila) homolog 4 3. 6 407978 AW385129 Hs. 41717 phosphodiesterase tA. calmodulin-depende 3. 6 426452 AW614271 Hs. 121647 ESTs Highly similar to AC006014 8 simil 3. 6 400685 3. 6 417154 A1674701 Hs. 21388 ESTs 3. 6 447176 Z42549 Hs. 160893 ESTs 3. 6 423893 AL031709 Hs. 134846 Human DNA sequence from clone 316G12 on 3. 6 449231 BE410360 Hs. 298573 KIAA1720 protein 3. 6 411607 AW853498 gb : RC1-CT0252-170200-025-h02CT0252Homo 3. 6 405977 3. 6 441470 BE503874 Hs. 301986 ESTs 3. 6 423568 NM005256 Hs. 129818 growth arrest-specific 2 3. 6 441235 Api884586 Hs. 135570 Homo sapiens cDNA : FLJ21268 fis, clone C 3. 6 450236 AW162998 Hs. 24684 KIAA1376 protein 3. 6 425364 AF052150 Hs. 155959 Homo sapiens clone 24533 mRNA sequence 3. 6 426775 AA384564 Hs. 108829 ESTs 3. 6 414831 M31158 Hs. 77439 protein kinase, cAMP-dependent regulato 3. 6 416876 AW501916 Hs. 117897 ESTs 3. 6 400878 3. 6 425153 AW023193 Hs. 27046 ESTs 3. 6 432222 A1204995 gb : anO3cO3. x1 Siralagene schizo brån S1 3. 5 415047 F13142 gb : HSC3JD031 normalized infant brain cDN 3. 5 401532 3. 5 446495 D60923 Hs. 153460 ESTs 3. 5 431325 AW026751 Hs. 5794 ESTs Weakly similar to 2109260A B cell 3. 5 445898 AF070623 Hs. 13423 Homo sapiens clone 24468 mRNA sequence 3. 5 455901 BE155527 gb : PM1-HT0350-190400-013-bO8 HT0350 Homo 3. 5 416421 AA134006 Hs. 79306 eukaryolic translation initiation factor 3. 5 455697 BE067952 gb : CMO-BT0365-061299-122-g09 BT0365 Homo 3. 5 405678 3. 5 418207 C14685 Hs. 34772 ESTs. 3 5 425383 D83407 Hs. 156007 Down syndrome critical region gene 1-lik 3. 5 417027 AA192306 Hs. 23926 triazin 3. 5 408367 AK001178 Hs. 44424 homolog of rat orphan transporter v7-3 3. 5 417702 R09935 Hs. 191146 ESTs 3. 5 445687 W80382 Hs. 149297 ESTs 3. 5 408776 AA057365 Hs. 63356 ESTs Weakly similar to 138022 hypolheti 3. 5

413164 BE068494 gb : MR1-BT0371-050500-009-a12BT0371 Homo 3. 5 414593 BE386764 gb : 601273249F1 NlH_MGC_20Homosapiensc 3. 5 453220 AB033089 Hs. 32452 Homo sapiens mRNA for KIAA1263 protein, 3. 5 415621 A1648602 Hs. 55468 ESTs 3. 5 454437 A1248173 Hs. 191460 hypolhetical protein MGC12936 3. 5 446066 A1343931 Hs. 149383 ESTs 3. 5 423374 AB037770 Hs. 127656 KIAA1349 protein 3. 5 419347 C15944 Hs. 90005 superiorcervical ganglia, neural specif) 3. 5 418516 NM006218 Hs. 85701 phosphoinositide-3-kinase. catalytic, al 3. 5 451776 W45679 Hs. 169854 hypothetical protein SP192 3. 5 432305 M62402 Hs. 274313 insulin-like growth factor binding prote 3. 5 456995 T89832 Hs. 170278 ESTs 3. 5 403323 3. 5 425022 M95724 Hs. 154207 centromere protein C 1 3. 5 439394 AA149250 Hs. 56105 ESTs 3. 4 433803 Api823593 Hs. 27688 ESTs 3. 4 450715 A1266484 Hs. 31570 ESTs, Weakly similar to KIAA1324 prolein 3. 4 411474 AW848427 gb : IL3-CT0214-150200-07SH10 CT0214 Homo 3. 4 415076 NM_000857 Hs. 77890 guanylate cydase 1, soluble, beta 3 3. 4 423826 U20325 Hs. 1707 cocaine-and amphetamine-regulated trans 3. 4 459495 BE544158 gb : 601076707F1NIH MGC_12Homosapiensc 3. 4 427173 BE255017 Hs. 97540 ESTs 3. 4 408112 AW451982 Hs. 248613 ESTs 3. 4 446092 N33522 Hs. 145894 ESTs 3. 4 416868 AI656856 Hs. 292597 ESTs 3. 4 458234 BE551408 Hs. 127196 ESTs 3. 4 419555 AA244416 gb : nc07d11. s1 NCI CGAP Pr1 Homosapiens 3. 4 414314 BE312991 gb : 601150275F1NIH_MGC_19Homosapiensc 3. 4 400425 AY004252 Hs. 287385 PR domain containing 12 3. 4 414366 BE549143 gb : 601076456F1NIH_MGC_12Homosapiensc 3. 4 434053 AW445136 Hs. 134946 ESTs 3. 4 449997 A1683052 Hs. 201577 KIAA1829 protein 3. 4 433461 A1636047 Hs. 197623 ESTs 3. 4 428006 AA418743 Hs. 98306 KIAA1862 protein 3. 4 424695 U58331 Hs. 151899 sarcoglycan, delta (35kD dystrophin-asso 3. 4 443294 A1733625 Hs. 133053 ESTs 3. 4 428212 AW444451 Hs. 134812 ESTs 3. 4 457673 AA551569 Hs. 272034 hypothetical protein PR02822 3. 4 446390 AA233393 Hs. 14992 hypothetical protein FU11151 3. 3 428536 At143139 Hs. 2288 visinin-like 1 3. 3 426597 AA382250 Hs. 145601 ESTs 3. 3 410366 A1267589 Hs. 302689 hypothetical protein 3. 3 458258 AW406546 Hs. 127971 ESTs 3. 3 401738 3. 3 409038 T97490 Hs. 50002 small inducible cytokine subfamily A (Cy 3. 3 425785 T27017 Hs. 159528 Homo sapiens clone 24400 mRNA sequence 3. 3 433328 AW298159 Hs. 23644 ESTs, Weakly similar to S65824 reverse t 3. 3 414541 BE293116 Hs. 76392 aldehyde dehydrogenase 1 family, member 33 434998 AW975157 Hs. 26037 ESTs 3. 3 456359 A1967991 Hs. 93574 homeo box D3 3. 3 426527 Nom-001037 Hs. 170238 sodium channel, voltage-gated, type 1, b 3. 3 454267 AA437199 Hs. 656 cell division cycle 25C 3. 3 400302 N48056 Hs. 1915 folate hydrolase (prostate-specific memb 3. 3 434077 AF116659 Hs. 321151 Homo sapiens PR01412 mRNA, complete cds 3. 3 436602 A1793222 Hs. 166817 ESTs 3. 3 449204 AB000099 Hs. 23251 Down syndrome critical region gene 4 3. 3 417935 R53697 Hs. 170044 ESTs 3. 3 423310 AA325225 Hs. 124023 Homo sapiens cDNA FW14218 hs, clone NT 3. 3 436624 T64297 Hs. 5241 fatty acid binding protein 1, liver 3. 3 453406 A1192987 Hs. 61784 hypothetical protein FLJ14451 3. 3 420164 AW339037 Hs. 24908 ESTs 3. 3 447826 AW779317 Hs. 258556 ESTs 3. 3 419875 AA853410 Hs. 93557 proenkephalin 3. 3 444612 AW138111 Hs. 22902 ESTs 3. 3 418504 BE159718 Hs. 85335 Homo sapiens mRNA ; cDNADKFZp564D1462 (f 3. 2 415242 R45986 Hs. 295014 ESTs 3. 2 418188 AW139413 Hs. 151880 ESTs 3. 2 430355 Nom-006219 Hs. 239818 phosphoinosi6de-3-kinase, catalytic, be 3. 2 421640 AW966652 gb : EST378726 MAGE resequences, MAGI Homo 3. 2 432359 AA076049 Hs. 274415 Homo sapiens cDNA FLJ 10229 fis, clone HE 3. 2 408806 AW847814 Hs. 289005 Homo sapiens cDNA : FU21532 fis, clone C 3. 2 400409 AF153341 Hs. 283954 Homo sapiens winged helix/forkhead irans 3. 2 446015 T30968 Hs. 13531 hypotheticat protein FU10971 3. 2 425495 AA358454 Hs. 78026 ESTs, Weakly similar to similar to ankyr 3. 2 403092 3. 2 452971 AI873878 Hs. 91789 ESTs 3. 2 454186 BE141030 gb : MRO-HT0067-201099-002-h11 HT0067 Homo 3. 2 401485 3. 2 401949 3. 2 457452 AW972675 gb : EST384766 MAGE resequences. MAGL Homo 3. 2 454100 A1693231 Hs. 126043 chromosome 21 open reading frame 51 3. 2 448440 AA173467 Hs. 62402 p21/Cdc42/Ræ1-æUvaled kinase 1 (yeast 3. 2 421200 AA284811 Hs. 264433 ESTs 3. 2

430142 NM 000437 Hs. 234392 piateiet-actiwating factor acetylhydrola 3. 2 433197 AB040889 Hs. 281022 KIAA1456 protein 3. 2 443509 AV645470 gb : AV645470 GLC Homo sapiens cDNA clone 3. 2 440827 A1733110 Hs. 128128 ESTs 3. 2 432799 NMJ) 16161 Hs. 278960 alpha-1 4-N-æeqlglucosaminyliransferas 3. 2 409257 AW370362 gb : RC1 BT0255-18109gO12-dO7BT0255Homo 3. 2 459235 BE246010 Hs. 271468 Homo sapiens mRNA for FLJ00038 protein, 3. 2 416789 AA223439 Hs. 79933 cyclin 1 3. 2 429809 AL162010 Hs. 223603 HomosapiensmRNA ; cDNADKFZp761D09121 (3. 2 420156 AW449258 Hs. 6187 ESTs 3. 2 455577 BE006341 gb : RC2-BN0127-240300-011-b05BN0127Homo 3. 2 400617 AF151064 Hs. 36069 hypothetical protein 3. 2 437129 AL049327 Hs. 302057 Homo sapiens mRNA ; cDNA DKFZp564E016 (fr 3. 2 451820 AW058357 Hs. 337353 ESTs 3. 2 457535 AA609685 Hs. 278672 membrane component, chromosome H. surfa 3. 2 419956 AL137939 Hs. 40096 ESTs 3. 1 456235 AA203637 gb : zx58b12. r1 Soares_élaUiver_spleen_ 3. 1 423930 AA332697 Hs. 42721 ESTs 3. 1 403796 3. 1 414085 AA114016 Hs. 75746 aldehyde dehydrogenase 1 family, member 3. 1 445886 A1793176 Hs. 145596 ESTs 3. 1 414401 A1760159 Hs. 124833 ESTs 3. 1 441573 BE563966 Hs. 6529 ESTs, Weakly similar to 178885 sedneith 3. 1 450725 R71389 Hs. 175951 ESTs 3. 1 458805 A1282933 Hs. 23294 hypothetical protein FU14393 3. 1 417868 A1078534 Hs. 122592 ESTs 3. 1 458391 A1792628 Hs. 133273 ESTs 3. 1 423346 A1267677 Hs. 127416 synaptojanin 1 3. 1 454486 AW857077 gb : RC1-CT0302-140300-016-f04CT0302Homo 3. 1 408341 AW182952 Hs. 249957 ESTs 3. 1 410669 AW805749 Hs. 318885 superoxide dismutase 2, mitochondrial 3. 1 404907 3. 1 434910 A1333863 Hs. 215474 ESTs, Moderately similar to alternative) 3. 1 436990 A1149729 Hs. 120557 ESTs 3. 1 441921 A) 733376 Hs. 164478 hypolhe6calproleinFLJ21939similarlo 3. 1 454673 AW812807 gb : RC3-ST0186-070100-016-04 ST0186 Homo 3. 1 429470 A1878901 Hs. 203862 guanine nucleotide binding protein (G pr 3. 1 404345 AA730407 Hs. 159156 protocadherin 11 3. 1 408217 Ait3201 Hs. 279860 tumor protein, iranslationally-controlle 3. 1 417313 AA195602 gb : zr32fO9. r1 Soares_NhHMPu_S1 Homosapi 3. 1 427322 AK002017 Hs. 176227 hypotheticalprotein FLJ11155 3. 1 411003 AA181018 Hs. 13056 hypothetical protein FLJ13920 3. 1 425339 AA936330 Hs. 198113 ESTs 3. 1 426716 NM 006379 Hs. 171921 sema domain, immunoglobulin domain (tu). 3. 1 449078 AK001256 Hs. 22975 KIAA1576 protein 3. 1 429608 U49250 Hs. 210862 T-box, brain, 1 3. 1 442308 AA989402 Hs. 111 fibroblast growth factor 9 (glia-activat 3. 1 428465 AW970976 Hs. 293653 ESTs 3. 1 411666 AF106564 Hs. 71346 neurohlamenl3 (150kDmedium) 3. 1 447965 AW292577 Hs. 94445 ESTs 3. 1 413918 AW015898 Hs. 71245 ESTs 3. 1 419682 H13139 Hs. 92282 paired-like homeodomain transcription fa 3. 1 425810 A1923627 Hs. 31903 ESTs 3. 1 427865 AA416931 Hs. 126065 ESTs 3. 1 429060 AW139155 Hs. 194995 hypothetical protein DKFZp43400320 3. 1 430708 U78308 Hs. 278485 olfactory receptor, family 1, subfamily 3. 1 448084 A1467800 Hs. 271000 ESTs. Weakly similar to 138022 hypothe6 3. 1 454506 AW847346 gb : RCO-CT0205-240999-021-e1 CT0205 Homo 3. 1 414629 AA345824 Hs. 76688 carboxylesterase 1 (monocyte/macrophage 3. 0 422963 M79141 Hs. 13234 ESTs 3. 0 417696 BE241624 Hs. 82401 CD69 antigen (p60, early T-cell ac6va6 3. 0 448175 BE296174 Hs. 225160 hypothetical protein FU 13102 3. 0 414686 BE409757 Hs. 23189 ESTs, Moderately similar to TBB2_HUMAN T 3. 0 458360 A1027207 Hs. 132253 ESTs 3. 0 451829 AW964081 Hs. 247377 ESTs 3. 0 445179 A1949743 Hs. 224768 ESTs 3. 0 433090 A1720050 Hs. 145362 immortalization-upregutated protein 3. 0 432018 AA524447 Hs. 152377 ESTs 3. 0 407988 N47760 Hs. 285107 hypotheticalprotein FU13397 3. 0 405911 3. 0 418808 A1821836 Hs. 10359 ESTs 3. 0 431900 AW972048 Hs. 192534 ESTs 3. 0 452893 H18017 Hs. 22869 ESTs, Moderately similar to KIAAi395 pro 3. 0 423952 AW877787 Hs. 136102 KIAA0853 protein 3. 0 412000 AW576555 Hs. 15780 ATP-binding cassette, sub-family A (ABC1 3. 0 405793 3. 0 410711 AB002316 Hs. 65746 KIAA0318 protein 3. 0 411279 AW884776 gb : QV4-OT0067-010300-121-d01 OT0067 Homo 3. 0 423957 AW978309 Hs. 136235 Homo sapiens cDNA FLJ13542 hs, clone PL 3. 0 427071 AA397958 Hs. 192719 ESTs 3. 0 434961 AW974956 gb : EST387061 MAGE resequences, MAGN Homo 3. 0 TABLE 10B :

Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 409257 1112994_1 AW370362AW809101 409840 1156071_1 AW502122 AW502125 AW501663 AW501720 411052 1230374 1 AW814950 R98513 H69459 BE176242 H54583 411279 1237516_1 AW884776 AW935737 AW835261 AW835247 AW835246 AW835263 AW835240 AW835258 411474 1247047_2 AW848427 AW848890 AW848159 AW848118 AW848634 AW848285 AW848086 AW848485 AW848283 AW848162 411607 1251251_1 AW853498 AW853442 AW853590 AW853433 AW853592 411772 12573861 BE170301AW861539AW904851BE154336BE154090BE154275 412112 1277883_1 BE180342 BE180347 AW901900 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE180228 AW901897 BE180224 AW901898 BE180223 BE180219 BE180346 BE180343 BE180418 BE180225 BE180221 BE180341 AW901894 BE180217 BE180227AW901891 BE180345 AW893614 AW893615 H85799 H83501 BE180220 413164 1351422_1 BE068494 BE068414 BE068332 BE068347 BE068706 BE068623 BE068450 BE068480 BE068350 BE068295 BE068498 BE068765 BE068328 BE068778 BE068671 BE068526 BE068493 BE068433 BE068740 BE068306 BE068631 BE068580 BE068445 BE068567 BE068521 BE068549 BE068392 BE068307 BE068692 BE068473 BE068754 BE068476 BE068685 BE068626 BE068591 BE068745 BE068434 BE068759 BE068628 BE068723 BE068529 BE068689 BE068383 BE068422 BE068470 BE068522 BE068618 BE068354 BE068748 BE068683 BE068303 BE068602 BE068739 BE068374 BE068302 BE068625 BE068596 BE068663 BE068429 BE068605 BE068693 BE068672 BE068401 BE068579 BE068329 BE068390 BE068419 BE068393 BE068447 BE068675 BE068311 BE068540 BE068301 BE068543 BE068719 BE068369 BE068324 BE068588 BE068568 BE068317 BE068384 BE068547 BE068674 BE068436 BE068321 BE068361 BE068676 BE068499 BE068299 BE068352 BE068410 BE068293 BE068418 BE068552 BE068598 BE068327 BE068550 BE068712 BE068661 BE068733 BE068525 BE068752 BE068357 BE068330 BE068565 BE068538 BE068340 BE068537 BE068761 BE068632 BE068758 413493 1373555 1 BE144444 BE144430 413510 1374377 1 F13044T77009BE145525BE145493 413544 1375671 1 BE147225 BE147205 BE147234 414220 1426940 1 BE298094 BE267860 414314 1435028_1 BE312991 BE272945 414366 1438636 1 BE549143 BE390613 BE277344 414456 1447655_1 H74314 BE299593 414593 1464909 1 BE386764 BE387560 414630 1468083 1 BE410857 BE390605 415047 1517450 1 F13142 Z42926 F06135 F06147 H08517 D51360 T75341 417313 166644 1 AA195602 W01148 N40632 417888 1706092 1 R23053 R79884 R76271 419555 185884 1 M244416M244401 421249 20064991 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204833_1 AW966652 AW966653 M294989 M385977 421813 207654_1 BE048255M313083M298419 422760 221034 1 BE409561 BE162756AW732798 425526 252776 1 AA359933 AA358889 AW955306 AW962995 AW837746 AW837755 AW837697 430212 314437 1 M469153A1718503M469225 432222 34x347_1 A1204995 AW827539 AW969908 AW440776 M528756 433389 36497_1 AF038171 Z43209 F07347 434961 396357 1 AW974956 AA781075 AA654944 435752 41050 1 AF230801 AF230800AA401795 AA398260 437483 43756 1 AL390174 AW898817 440198 48824-2 BE560093 443509 57199 1 AV645470 T84636 T82805 446052 65988_1 M358760 M158850 AW062737 AW062738 AV656291 446218 66686_1 AV657159 BE145509 BE145512 BE145505 BE145507 447135 70963_1 T58148 AW516579 AW059603 452346 912206 1 BE243534 BE243752 A1880228 L44326 452502 919733 1 A1904296 BE007223 R30687 454065 998401_1 BE394588 AW024754 BE183166 BE183167 454186 1049791 1 BE141030BE141474BE141467BE141753BE141024BE141761AW177583AW17 7579AW177582AW177585AW177587AW807582AW177581 BE141477 BE141 520 BE141456 BE141492 BE141028 BE141775 BE141489 BE141751 AW177599 BE141750AW177597 BE141512 BE141460 BE141749 AW177598 454339 1122972 1 AW381980 BE152244 BE152235 BE152238 BE152232 454486 1215703 1 AW857077AW861268AW847383AW795787 454506 1219857 1 AW847346 AW847395 AW847408 AW847385 AW847342 AW847396 AW847339 AW801718 AW801787 454673 12286691 AW812807AW812815AW812802 455040 1250028_1 AW852286 AW851934 AW852096 AW852274 455225 1262318 1 AW996689 AW996380 AW996453 BE085650 AW868687 BE085595 455577 1333898 1 BE006341 BE006307 BE006311 455617 13461 17_1 BE078070 BE061030 BE077927 455697 1351148 1 BE067952 BE067945 BE067942 BE067943 BE067949 BE067954 BE067944 BE067953 BE067956 BE067946 455901 1381569_1 BE155527 BE155503 BE155188 BE155126 456235 168686 1 AA203637 AA832266 H67452 456407 184986 1 AW968614M243209M281411 457452 339381 1 AW972675AA541366AA523039 459150 919196J BE155356 BE153488 BE153461 BE155059 BE155210 BE155413 BE153577 BE153688 BE155063 BE155347 A1903640 BE155492 TABLE 1OC : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 400661 8118474 Plus 84912-85187

400685 8118768 Minus 72969-73050, 73713-73800 400865 1945037 Minus 44482-45526 400878 9864757 Plus 31493-32842 401024 8117489 Plus 60551-60802 401315 9212516 Minus 198960-199619 401485 7341723 Plus 68009-68209, 68841-69077 401521 7705251 Plus 9127-9234 401532 7798785 Plus 124414-124950, 125050-125418 401738 2982169 Minus 41547-41757 401780 7249190 Minus 28397-28617, 28920-29045, 29135-29296, 29411-29567, 29705-29787, 30224-30573 401836 7534063 Plus 71981-72084 401949 3492889 Plus 160728-161660 402092 7249154 Minus 107533-108094 402176 7543687 Minus 10-750 402546 7637348 Plus 24673-25170 403092 8954241 Plus 174720-175016. 175104-175406, 175508-175813 403180 7523976 Minus 63603-63759 403323 8348082 Minus 120366-120845 403796 8099896 Minus 75073-77664 404391 3135305 Minus 26030-26173, 27852-27997 404769 8099713 Minus 175801-176823 404793 7232206 Minus 61087-61590 404828 6580415 Minus 26291-27253 404907 7331453 Minus 102880-103828 404958 7407941 Minus 2731-4531 405071 7708797 Minus 11115-11552 405130 8516045 Plus 150235-150449 405138 8576241 Plus 90303-90516 405354 2642452 Plus 52213-53089 405377 5649375 Plus 216656-216848 405629 4508116 Minus 101678-101866 405678 4079670 Plus 151821-152027 405793 1405887 Minus 89197-89453 405800 2791346 Plus 19271-19813 405867 6758731 Minus 74553-75173 405911 6758795 Plus 101008-101643 405977 8247789 Minus 135548-136177 TABLE 11A : ABOUT 533 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES Table 11A lists about 533 CNS-enriched genes significantly down-regulated in glioblastoma compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymetdx/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to'average'gliobiastoma was greater than or equal to 2. The'average'normal CNS level was set to the 75th percentile amongst various normal CNS tissues. The'average'glioblastoma level was set to the 85th percent amongst various tumor samples. To enrich for CNS specific genes, the ratio of'average'CNS to'average'non-CNS normal adult tissues was calculated to be greater than or equal to 2. The'average'CNS level was set to the 85th percentage amongst vrious CNS tissues. The'average'normal non-CNS adult tissue level was set to the 85th percentile amongst various non-CNS normal tissues. In order to remove gene-specific background levels of non-specific hybridization, the 1 0th percenble value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratios were evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene TiUe : Unigene gene Utle R1 : Ratio of 75th percentile normal central nervous system tissue to 85th percentite tumor R2 : Ratio of 85th percent central nervous system tissue to 85th percentile normal body tissue Pkey ExAccn UnigenelD Unigene Title R1 R2 417275 X63578 Hs. 295449 parvalbumin 29. 0 30. 0 430829 AW451999 Hs. 194024 ESTs 25. 7 6. 2 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 22. 6 25. 8 419954 014720 Hs. 93883 myelin protein zero (Charcot-Marie-Tooth 21. 2 30. 3 416133 NM001683 Hs. 89512 ATPase, Ca-transporting, plasma membra 15. 5 16. 8 416018 AW138239 Hs. 78977 proprotein convertase subtilisin/kexin t 15. 2 18. 0 417167 AW206437 Hs. 4290 ESTs 14. 8 17. 7 433940 H05129 Hs. 7459 cyclic AMP-regulated phosphoprotein, 21 13. 4 18. 1 413324 V00571 Hs. 75294 corticotropin eleasing hommone 131 18. 0 439830 AA846666 Hs. 151489 ESTs, WeaklysimilartoXE7_HUMANPROTEt 12. 6 16. 5 408068 AW148652 Hs. 167398 ESTs 12. 6 16. 9 429096 AB011106 Hs. 196012 KIAA0534 protein 12. 2 21. 1 412638 AA910199 Hs. 203838 ESTs 12. 2 16. 0 442593 R39804 Hs. 31961 ESTs 10. 8 15. 0 446353 A1290919 Hs. 153661 ESTs 10. 4 13. 2 426365 AA376667 Hs. 10283 RNA binding motif protein BB 10. 0 5. 9 414937 R38698 Hs. 12382 ESTs 10. 0 10. 8 419643 F06066 Hs. 91791 chromosome 11 open reading frame 25 9. 5 10. 9 412454 R55745 Hs. 167330 ESTs 9. 5 14. 1 439366 AF100143 Hs. 6540 fibroblast growth factor 13 9. 4 12. 3 441790 AW294909 Hs. 132208 ESTs 9. 2 3. 2 448117 H49129 Hs. 172982 ESTs 9. 1 12. 8 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheG 9. 0 14. 7 412453 R20205 Hs. 167330 ESTs 9. 0 13. 7 408920 AL120071 Hs. 48998 fibronectin leucine rich transmembrane p 8. 9 17. 3 409031 AA376836 Hs. 76728 ESTs 8. 7 8. 6 446544 AI631932 Hs. 7047 ESTs, Weakly similar to Unknown [H. sapie 8. 2 20. 0 439480 AL038511 Hs. 125316 ESTs. Weakly similar to S33990 finger pr 8. 2 8. 3

410200 AA082557 Hs. 101915 Stargardt disease 3 (autosomal dominant) 8. 0 8. 9 408428 NM 014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 7. 9 9. 6 437073 Api885608 Hs. 94122 ESTs 7. 9 11. 3 408434 AW195317 Hs. 107716 hypothetical protein FU22344 7. 9 16. 4 440209 H05049 Hs. 22269 neurexin 3 7. 8 34. 3 408119 W26213 Hs. 101672 ESTs, Weakly similar to T00331 hypotheti 7. 8 9. 0 429611 AI889077 Hs. 211388 Homo sapiens BAC clone CTB-6ON22 from 7q 7. 7 5. 0 423440 R25234 Hs. 143434 contacfin 1 7. 7 9. 9 445148 A1214510 Hs. 146304 ESTs 7. 6 9. 1 416294 D86980 Hs. 79170 KiM0227 protein 7. 6 7. 6 424087 N69333 Hs. 143434 contacfin 1 7. 6 10. 3 437479 R61866 Hs. 101277 ESTs 7. 5 9. 3 430573 AA744550 Hs. 136345 ESTs 7. 1 2. 8 448958 AB020651 Hs. 22653 KIAA0844 protein 7. 1 10. 4 419474 AW968619 Hs. 155849 ESTs 7. 1 3. 0 423605 AF047826 Hs. 129887 cadherin 19, type 2 7. 0 6. 9 433098 AW190593 Hs. 151143 ESTs 7. 0 9. 2 449511 A ! 436187 Hs. 296261 guanine nucleo6de binding protein (G pr 6. 9 3. 1 428414 AL049980 Hs. 184216 DKFZP564C152protein 6. 8 5. 0 443155 R54485 Hs. 23772 ESTs 6. 8 3. 5 450561 R49674 Hs. 25909 ESTs 6. 8 8. 1 433068 NM006456 Hs. 288215 sialyltransferase 6. 8 2. 0 423589 AA328082 Hs. 209569 ESTs 6. 6 10. 5 415681 A1379882 Hs. 72630 ESTs 6. 5 9. 0 413510 F13044 gb : HSC3HH101 normalized infantbraincDN 6. 4 7. 1 427992 Y15014 Hs. 181353 UDP-Gal : betaGIcNAc beta 1, 3-galaclosyltr 6. 4 9. 5 450642 R39773 Hs. 7130 copine IV 6. 4 5. 7 429322 D86984 Hs. 199243 KIAA0231 protein 6. 4 8. 2 447482 AB033059 Hs. 18705 KIAA1233 protein 6. 4 2. 3 446129 AW244073 Hs. 145946 ESTs 6. 3 8. 3 421913 A1934365 Hs. 109439 osteoglycin (osteoinductive factor, mime 6. 3 2. 1 434273 AA913143 Hs. 26303 ESTs 6. 2 10. 3 408480 Al350337 Hs. 164568 fibroblast growth factor 7 (kerabnocyte 6. 2 3. 5 451301 A1769514 Hs. 209890 EST 6. 2 12. 4 438356 AA805530 Hs. 48527 ESTs 6. 2 8. 1 426388 AW081394 Hs. 97103 ESTs 6. 2 8. 6 452502 Al904296 gb : PM-BT046-220199-2861BT046Homosapi 6. 1 2. 8 408165 AL137573 Hs. 43143 Homo sapiens mRNA ; cDNADKFZp564A2463 (f 6. 1 6. 3 442979 AW440782 Hs. 174743 ESTs 6. 1 6. 3 408713 NM001248 Hs. 47042 ectonucleosidetriphosphatediphosphohyd 6. 0 3. 8 430004 U27768 Hs. 227571 regulator of G-protein signalling 4 5. 9 21. 4 425087 R62424 Hs. 126059 ESTs 5. 9 8. 1 441695 T12411 Hs. 183745 hypothetical protein FLJ13456 5. 9 3. 1 417175 R44558 Hs. 94002 ESTs 5. 8 12. 5 437483 AL390174 gb : Homo sapiens mRNA ; cDNA DKFZp547J184 5. 8 2. 2 436427 A1344378 Hs. 143399 ESTs 5. 8 13. 8 450382 AA397658 Hs. 60257 Homo sapiens cDNA FLJ 13598 fis, clone PL 5. 7 4. 4 408478 Nom-000806 Hs. 45740 gamma-aminobutyric æid (GABA) A recepto 5. 7 12. 5 442676 A1733585 Hs. 130897 ESTs 5. 7 6. 8 446443 AV659082 Hs. 134228 ESTs 5. 7 6. 4 459080 AW192083 Hs. 290855 ESTs 5. 6 15. 6 431984 AL080239 Hs. 272284 Human DNA sequence from clone GS1-256022 5. 6 8. 2 428356 AL046991 Hs. 10338 ESTs 5. 6 6. 2 417877 A1025829 Hs. 86320 ESTs 5. 4 4. 9 429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 5. 3 13. 1 408556 U49516 Hs. 46362 5-hydroxytryptamine (serotonin) receptor 5. 3 6. 6 431930 AB035301 Hs. 272211 cadherin 7, type 2 5. 2 6. 0 438285 AA782845 Hs. 22790 ESTs 5. 2 7. 3 439901 N73885 Hs. 124169 ESTs 5. 2 2. 7 449222 AW293984 Hs. 197621 ESTs 5. 2 8. 1 408016 AW136827 Hs. 256096 ESTs 5. 1 2. 5 436953 AW959074 Hs. 23648 HomosapienscDNAFW13097hs, cloneNT 5. 1 3. 0 436773 AW078629 Hs. 82110 PC4 and SFRS1 interacting protein 1 5. 1 7. 3 409263 AA069573 Hs. 50319 ESTs 5. 1 12. 9 453830 AA534296 Hs. 20953 ESTs 5. 1 3. 4 441535 AL135735 Hs. 7885 phosphatidylinositol binding clathrin as 5. 0 4. 8 416490 AF090116 Hs. 79348 regulatorofG-proteinsignalling7 5. 0 20. 1 417284 N62889 Hs. 107242 Homo sapiens cDNA FLJ12965 fis, clone NT 5. 0 3. 9 448605 AL109678 Hs. 21597 Homo sapiens mRNA futl length insen cDN 5. 0 6. 1 442240 Al791883 Hs. 292719 ESTs 4. 9 6. 7 427972 AA864870 Hs. 181304 putative gene product 4. 9 5. 2 416040 AW819158 Hs. 289044 Homo sapiens CDNA FU 12048 fis, clone HE 4. 9 2. 8 444922 AI921750 Hs. 144871 Homo sapiens cDNA FU13752 fis, clone PL 4. 8 3. 7 408936 AL138043 Hs. 293549 ESTs 4. 8 6. 6 414943 D80647 Hs. 124193 ESTs 4. 8 3. 1 429254 H10133 Hs. 91846 hypothe6cal protein DKFZp761C121 4. 8 2. 3 407906 AA369665 Hs. 41185 Homo sapiens mRNA ; cDNADKFZp56401262 (f 4. 8 9. 1 416577 BE063207 Hs. 79381 grancalcin 4. 7 2. 2 420480 AL137361 Hs. 98173 hypothetical protein 4. 7 2. 8 404793 4. 6 2. 2 430895 U66581 Hs. 248121 G protein-coupled receptor 22 4. 6 7. 4 438571 AW020775 Hs. 56022 ESTs 4. 6 5. 4 444585 AW170015 Hs. 6594 ESTs 4. 6 6. 0

414272 A1651603 Hs. 46988 ESTs 4. 5 2. 2 414699 A1815523 Hs. 76930 synuclein, alpha (nonA4compnentofam 4. 5 30. 9 423449 Al497900 Hs. 33067 ESTs 4. 5 20. 8 433521 T66087 Hs. 112482 Homo sapiens unknown mRNA sequence 4. 4 2. 0 429876 AB028977 Hs. 225974 KIAA1054 protein 4. 4 19. 2 429726 AW628326 Hs. 27151 ESTs 4. 4 10. 2 449093 AB035356 Hs. 22998 neurexin 1 4. 4 9. 4 415716 N59294 Hs. 179662 nucleosome assembly prolein 1-like 1 4. 4 15. 1 419656 AB002314 Hs. 92025 KIAA0316 gene product 4. 4 8. 2 425864 U56420 Hs. 159903 olfactory receptor, family 5, subfamily 4. 4 2. 4 435078 AW518888 Hs. 40937 ESTs 4. 4 5. 7 432712 AB016247 Hs. 288031 sterol-C5-desaturase (fungal ERG3, delta 4. 3 5. 9 426867 AA460967 Hs. 22668 ESTs 4. 3 6. 0 412112 BE180342 gb : RC3-HT0622-130400-012-a07 HT0622 Homo 4. 3 3. 2 410171 H07892 Hs. 12431 ESTs 4. 3 5. 3 442339 BE299668 Hs. 227591 ESTs, Weakly similar to 1901303A Leu zip 4. 2 5. 0 421249 AA285362 gb : HTH277 HTCDLi Homo sapiens cDNA5'/3'4. 2 3. 5 422528 AB011182 Hs. 118087 KIAA0610 protein 4. 2 3. 9 434460 AA478486 Hs. 3852 KIAA0368 protein 4. 1 8. 3 410362 H04811 Hs. 93164 proprotein convertase subGlisinlkexin t 4. 1 7. 0 449754 H00820 Hs. 30977 ESTs, Weakly similar to B34087 hypotheti 4. 1 3. 9 408496 A1683802 Hs. 136182 ESTs 4. 1 4. 7 434101 AA625205 Hs. 259599 KIAA1622 protein 4. 1 6. 3 430212 AA469153 gb : nc67f04. s1 NCI CGAP_Pr1 Homosapiens 4. 0 2. 5 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 4. 0 7. 4 456407 AW968614 gb : EST380690MAGEnzse (tuences, iMiAGJHorno 4. 0 5. 1 441869 NM 003947 Hs. 8004 huntingGn-associated protein interactin 4. 0 32. 3 429628 H09604 Hs. 13268 ESTs 4. 0 4. 5 410087 F12079 Hs. 332579 ESTs 4. 0 6. 9 419910 AA662913 Hs. 190173 ESTs. Weakly similar to A46010 X-linked 4. 0 2. 6 441005 Z41305 Hs. 303172 HomosapiensmRNA ; cDNADKFZpS47G133 (fr 3. 9 21. 7 412677 AW029608 Hs. 17384 ESTs 3. 9 2. 2 453341 A1758912 Hs. 296341 adenylyl cyclase-associated protein 2 3. 9 7. 2 416854 H40164 Hs. 80296 Purkinje cell protein 4 3. 9 2. 2 414666 Nom 004466 Hs. 76828 glypican 5 3. 8 6. 2 418217 At910647 Hs. 13442 ESTs 3. 8 3. 2 421855 F06504 Hs. 27384 ESTs, ModeratetysimilartoALU4_HUMANA 3. 8 2. 2 414764 AW013887 Hs. 72047 ESTs 3. 8 10. 7 433629 R13140 Hs. 13359 ESTs 3. 7 2. 7 424738 Api963740 Hs. 46826 ESTs 3. 7 2. 1 407706 AA191085 Hs. 26612 ESTs, Moderately similar to S23650 retro 3. 7 5. 3 437268 A1754847 Hs. 227571 regulator of Gprotein signalling 4 3. 7 53. 7 423135 N67655 Hs. 26411 ESTs 3. 7 21. 7 446818 A1342668 Hs. 279765 ESTs 3. 7 2. 6 427562 R56424 Hs. 26534 ESTs 3. 6 3. 6 439274 AF086092 Hs. 48372 ESTs 3. 6 34. 5 452381 H23329 Hs. 290880 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 6 6. 0 422897 AA679784 Hs. 4290 ESTs 3. 6 5. 1 429656 X05608 Hs. 211584 neurofilament, light polypepUde (68kD) 3. 6 24. 6 417154 A1674701 Hs. 21388 ESTs 3. 6 5. 8 447176 Z42549 Hs. 160893 ESTs 3. 6 6. 4 405977 3. 6 3. 9 423568 NM_005256 Hs. 129818 growth arrest-specific 2 3. 6 2. 5 441235 A1884586 Hs. 135570 Homo sapiens cDNA : FLJ21268 fis, clone C 3. 6 5. 4 426775 AA384564 Hs. 108829 ESTs 3. 6 3. 4 414831 M31158 Hs. 77439 pnoteinkinase, cAMP-dependent, regulato 3. 6 2. 8 425153 AW023193 Hs. 27046 ESTs 3. 6 4. 9 446495 D60923 Hs. 153460 ESTs 3. 5 9. 8 445898 AF070623 Hs. 13423 Homo sapiens clone 24468 mRNA sequence 3. 5 16. 6 416421 AA134006 Hs. 79306 eukaryotic translation initiation factor 3. 5 5. 0 418207 C14685 Hs. 34772 ESTs 3. 5 16. 0 425383 D83407 Hs. 156007 Down syndrome critical region gene t-lik 3. 5 6. 2 417027 AA192306 Hs. 23926 triadin 3. 5 2. 5 408367 AK001178 Hs. 44424 homologofratorphantransponerv7-3 3. 5 5. 3 408776 AA057365 Hs. 63356 ESTs, Weakly similar to 138022 hypotheti 3. 5 5. 5 453220 AB033089 Hs. 32452 Homo sapiens MRNA for KIAAL 263 protein, 3. 5 23. 6 419347 C15944 Hs. 90005 superiorcervical ganglia, neura ! specifi 3. 5 42. 3 433803 A1823593 Hs. 27688 ESTs 3. 4 3. 6 450715 A1266484 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 3. 4 4. 1 415076 NM 000857 Hs. 77890 guanylate cyclase 1, soluble, beta 3 3. 4 9. 8 423826 U20325 Hs. 1707 cocaine-and amphetamine-regulated trans 3. 4 4. 7 427173 BE255017 Hs. 97540 ESTs 3. 4 2. 4 446092 N33522 Hs. 145894 ESTs 3. 4 3. 5 416868 A1656856 Hs. 292597 ESTs 3. 4 4. 5 458234 BE551408 Hs. 127196 ESTs 3. 4 4. 5 434053 AW445136 Hs. 134946 ESTs 34 39 428536 A1143139 Hs. 2288 visinin-like 1 3. 3 42. 3 410366 A1267589 Hs. 302689 hypothetical protein 3. 3 14. 4 425785 T27017 Hs. 159528 Homosapiensclone24400mRNAsequence 33 4. 6 434998 AW975157 Hs. 26037 ESTs 3. 3 4 7 456359 A1967991 Hs. 93574 homeo box D3 3. 3 4. 4 426527 NM 001037 Hs. 170238 sodium channel, voltage-gated, type l, b 3. 3 5. 2 400302 N48056 Hs. 1915 (olate hydrolase (prostate-specific memb 3. 3 9. 0

419875 AA853410 Hs. 93557 proenkephalin 3. 3 3. 6 444612 AW138111 Hs. 22902 ESTs 3. 3 3. 0 415242 R45986 Hs. 295014 ESTs 3. 2 2. 2 421640 AW966652 gb : EST378726 MAGE resequences, MAGI Homo 3. 2 3. 8 408806 AW847814 Hs. 289005 Homo sapiens cDNA : FU21532 fis, clone C 3. 2 2. 4 446015 T30968 Hs. 13531 hypothetical protein FU10971 3. 2 3. 2 425495 AA358454 Hs. 78026 ESTs, Weakly similar to similar to ankyr 3. 2 2. 2 403092 3. 2 2. 9 452971 AI873878 Hs. 91789 ESTs 3. 2 4. 5 454100 A1693231 Hs. 126043 chromosome 21 open reading frame 51 3. 2 2. 7 448440 AA173467 Hs. 62402 p21/Cdc42/Rae1-activatedkinase1 (yeast 3. 2 2. 8 421200 AA284811 Hs. 264433 ESTs 3. 2 2. 7 440827 A1733110 Hs. 128128 ESTs 3. 2 2. 1 429809 AL162010 Hs. 223603 HomosapiensmRNA ; cDNADKFZp761D09121 (3. 2 4. 3 420156 AW449258 Hs. 6187 ESTs 3. 2 19. 0 457535 AA609685 Hs. 278672 membrane componenl, chromosome 11, surfa 3. 2 2. 0 419956 AL137939 Hs. 40096 ESTs 3. 1 8. 7 423930 AA332697 Hs. 42721 ESTs 3. 1 2. 7 417868 A1078534 Hs. 122592 ESTs 3. 1 12. 6 423346 A1267677 Hs. 127416 synaplojanin 1 3. 1 12. 0 441921 Api733376 Hs. 164478 hypothetical protein FU21939 similar to 3. 1 4. 3 429470 A1878901 Hs. 203862 guanine nucleoUde binding protein (G pr 3. 1 5. 3 408217 Api433201 Hs. 279860 tumor protein, transla6onally-controlle 3. 1 7. 1 427322 AK002017 Hs. 176227 hypothetical protein FU11155 3. 1 6. 3 449078 AK001256 Hs. 22975 KIAA1576 protein 3. 1 30. 1 429608 U49250 Hs. 210862 T-box, brain, 1 3. 1 2. 2 442308 AA989402 Hs. 111 hbnoblastgnowthfætor9 (gtia-ac6vat 3. 1 3. 0 411666 AF106564 Hs. 71346 neumfilament3 (150kDmedium) 3. 1 10. 9 427865 AA416931 Hs. 126065 ESTs 3. 1 7. 5 430708 U78308 Hs. 278485 olfactory receptor, family 1, subfamily 3. 1 3. 4 451829 AW964081 Hs. 247377 ESTs 3. 0 6. 2 405911 3. 0 2. 4 418808 A1821836 Hs. 10359 ESTs 3. 0 6. 2 452893 H18017 Hs. 22869 ESTs. Moderately simil ar to KIAA 1395 pm 3. 0 5. 1 423952 AW877787 Hs. 136102 KIAA0853protein 3. 0 2. 1 412000 AW576555 Hs. 15780 ATP-binding cassette, sub-family A (ABC1 3. 0 2. 1 405793 3. 0 2. 7 410711 AB002316 Hs. 65746 KIAA0318 protein 3. 0 14. 3 427071 AA397958 Hs. 192719 ESTs 3. 0 2. 1 453534 NM_014796 Hs. 33187 KIAA0748 gene product 3. 0 14. 5 413903 AA496493 Hs. 23136 ESTs 3. 0 2. 2 426866 U02330 Hs. 172816 neuregulin1 30 11. 3 434945 AB033065 Hs. 4280 KIAA1239 protein 3. 0 3. 5 412639 AW961284 Hs. 296235 ESTs 2. 9 4. 9 453590 AF150278 Hs. 33578 KIAA0820 protein 2. 9 33. 1 414502 AL133721 Hs. 224680 ESTs 2. 9 2. 3 434367 AB020700 Hs. 3830 KtM0893 protein 2. 9 23. 1 425121 Api797511 Hs. 154679 synaptotagmin I 2. 9 8. 1 412494 AL133900 Hs. 792 ADP-ribosyla60nfætordomainprotein1 2. 9 20. 8 401213 2. 9 3. 2 401028 AW673312 Hs. 50848 hypothetical protein FLJ20331 2. 9 3. 4 415191 AA190381 Hs. 120810 ESTs 2. 9 3. 0 449275 AW450848 Hs. 205457 periaxin 2. 9 5. 6 419863 AW952691 Hs. 93485 HomosapiensmRNA : cDNADKFZp761D191 (fr 2. 9 35. 0 411421 BE272110 Hs. 21177 ESTs 2. 9 2. 0 430865 A1073424 Hs. 5232 HSPC125 protein 2. 9 11. 4 437486 AW952089 Hs. 5636 RAB6A, member RAS oncogene family 2. 9 2. 2 442357 A1458586 Hs. 135706 ESTs 2. 9 6. 0 408274 R17315 gb : yg12g11. r1Soaresinfantbrain1NIBH 2. 9 2. 2 444185 AW298350 Hs. 66020 ESTs 2. 8 5. 0 420173 AA256151 Hs. 22999 ESTs 2. 8 5. 1 428358 AA993222 Hs. 101915 Stargardtdisease3 (autosomaldominant) 2. 8 7. 0 447252 R90916 Hs. 12449 Homo sapiens transmembrane protein HTMP1 2. 8 4. 4 440260 A1972867 Hs. 7130 copine IV 2. 8 10. 6 417084 H08370 Hs. 33067 ESTs 2. 8 8. 4 438257 AW474419 Hs. 224794 ESTs 2. 8 2. 8 441934 T23939 Hs. 7344 ESTs 2. 8 6. 2 447885 F11528 Hs. 303172 Homo sapiens mRNA ; cDNA DKFZp547G133 (fr 2. 8 3. 5 423552 AF107028 Hs. 129783 sodium channel, voltage-gated, type 11, 2. 8 3. 4 450940 A1744943 Hs. 143209 ESTs, Weakly similar to 138022 hypotheti 2. 8 14. 4 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 2. 8 21. 7 445887 A1263105 Hs. 145597 ESTs 2. 8 5. 1 425494 N55540 Hs. 78026 ESTs. Weakly similar to similar to ankyr 2. 8 2. 4 438202 AW169287 Hs. 22588 ESTs 2. 8 11. 9 436199 R38946 Hs. 127951 hypothetical protein FLJ14503 2. 8 6. 0 434826 AF155661 Hs. 22265 pyruvate dehydrogenase phosphatase 2. 8 2. 4 415462 R52692 Hs. 12698 ESTs 2. 8 3. 4 418070 NM000844 Hs. 83407 glutamate receptor, metabotropic 7 2. 8 4. 5 432149 AW614326 Hs. 157022 ESTs, Weakly similar to T34549 probable 2. 8 9. 5 430371 D87466 Hs. 240112 KIAA0276 protein 2. 8 7. 0 437357 AL359559 Hs. 331666 Homo sapiens mRNA ; cDNA DKFZp76202215 (f 2. 7 2. 5 415838 R44336 Hs. 7093 ESTs 2. 7 3. 6 438675 AA813725 Hs. 213568 ESTs 2. 7 2. 5

419558 AW953679 gb : EST365749 MAGE resequences, MAGC Homo 2. 7 3. 1 446318 A1949389 Hs. 18067 ESTs 2. 7 4. 1 445183 AB007877 Hs. 12385 KIAA0417 gene product 2. 7 5. 3 457012 R41480 Hs. 127630 ESTs 2. 7 19. 0 431988 AC002302 Hs. 77202 protein kinase C, beta 1 2. 7 7. 2 430223 NMJM2514 Hs. 235935 nephroblastoma overexpressed gene 2. 7 2. 8 447932 AA837474 Hs. 20021 vesicle-associated membrane protein 1 (s 2. 7 3. 8 450214 BE439763 Hs. 227571 regulator of G-protein signalling 4 2. 7 6. 9 434731 AA648049 Hs. 121518 ESTs 2. 7 5. 0 428839 A1767756 Hs. 82302 Homo sapiens cDNAFU14814fis. done NT 2. 7 5. 2 407709 AA456135 Hs. 23023 ESTs 2. 7 2. 5 422420 U03398 Hs. 1524 tumor necrosis factor (ligand) superfami 2. 7 3. 3 443305 A1050693 Hs. 133318 ESTs 2. 7 5. 9 435648 H24347 Hs. 27524 ESTs 2. 7 15. 0 418407 AL044818 Hs. 84928 nuclear transcription factor Y, beta 2. 7 2. 7 436771 AW975687 Hs. 292979 ESTs 2. 7 6. 0 428689 NM014351 Hs. 189810 suffortranferase family 4A, member 1 2. 7 4. 8 440503 NM_006539 Hs. 7235 calcium channel, voltage-dependent, gamm 2. 7 4. 4 441006 AW605267 Hs. 7627 CGI-60 protein 2. 7 3. 1 410330 AW023630 Hs. 46786 ESTs 2. 6 29. 5 434398 AA121098 Hs. 3838 serum-inducible kinase 2. 6 2. 6 438831 BE263273 Hs. 6439 synapsin 11 2. 6 7. 8 419066 Z98492 Hs. 6975 PR01073 protein 2. 6 3. 4 412643 AW971239 Hs. 293982 ESTs 2. 6 2. 2 430456 AA314998 Hs. 241503 hypothetical protein 2. 6 17. 9 416498 U33632 Hs. 79351 potassium channel, subfamily K, member 1 2. 6 2. 9 401421 2. 6 2. 0 419530 X98330 Hs. 90821 ryanodine receptor 2 (cardiac) 2. 6 4. 2 441817 AW969706 Hs. 293332 ESTs 2. 6 3. 8 439203 AA448930 Hs. 8453 KIAA1587 protein 2. 6 4. 2 426054 U12431 Hs. 166109 ELAV (embryonic lethal, abnormal vision, 2. 6 5. 1 444583 AW994403 Hs. 100861 hypothetical protein FU) 4600 2. 6 3. 7 417919 Api928203 Hs. 86379 ESTs 2. 6 3. 0 434293 NM 004445 Hs. 3796 EphB6 2. 6 3. 2 431716 D89053 Hs. 2680 2 fatty-acid-Coenzyme A ligase, long-chain 2. 6 6. 4 443037 AW500305 Hs. 299166 syntaxin 7 2. 6 2. 2 440736 D56919 Hs. 265848 myomegalin 2. 6 7. 1 404648 2. 6 3. 0 429995 AA463571 gb : zx72eO9. r1 Soaes_totalJetus_Nb2HF8_ 2. 6 3. 5 436508 AW604381 Hs. 121121 ESTs, Weakly similar to S00755 pleckstri 2. 6 3. 9 441190 H09073 Hs. 25046 ESTs 2. 6 3. 1 432278 AL137506 Hs. 274256 hypotheticatproteinFLJ23563 2. 6 2. 9 442731 A1868167 Hs. 131044 ESTs 2. 6 4. 1 416836 D54745 Hs. 80247 cholecystokinin 2. 6 14. 9 449071 NM005872 Hs. 22960 breast carcinoma amplified sequence 2 2. 5 2. 4 436321 AA709133 Hs. 180144 ESTs 2. 5 2. 8 439693 A1741816 Hs. 125897 ESTs 2. 5 3. 6 443212 AW269515 Hs. 102500 hypothetical protein FLJ20481 2. 5 2. 8 423981 AL122104 Hs. 136664 Homo sapiens mRNA : cDNA DKFZp434A1627 (f 2. 5 3. 8 407868 NM000950 Hs. 40637 proline-rich Gla (G-carboxyglutamic acid 2. 5 3. 1 443992 AW022228 Hs. 322922 ESTs 2. 5 27. 9 444124 R43097 Hs. 6818 ESTs 2. 5 5. 3 411379 A1816344 Hs. 12554 ESTs, WeaklysimilartoNPL4_HUMANNUCLE 2. 5 38. 0 440474 A1207936 Hs. 7195 gamma-aminobutyric acid (GABA) A recepto 2. 5 3. 8 446277 A1284218 Hs. 159204 ESTs 2. 5 2. 2 410111 A1620206 Hs. 189647 ESTs 2. 5 3. 5 445162 AB011131 Hs. 12376 pieco) o (presynapticcytomatnxprotein) 2. 5 4. 8 410718 A1920783 Hs. 191435 ESTs 2. 5 4. 5 417201 T60432 Hs. 269084 ESTs, Moderately similar to AF0979994 L 2. 5 2. 9 420274 AW968000 Hs. 143389 ESTs, Weakly similar to TW18 ubiquifin 2. 5 2. 8 433496 AF064254 Hs. 49765 VLCS-H1 protein 2. 5 4. 7 437331 AL353933 Hs. 21710 hypothetical protein DKFZp761G0313 2. 5 3. 3 437368 A1471969 Hs. 182606 ESTs 2. 5 3. 0 441985 BE047625 Hs. 169815 ESTs 2. 5 3. 6 410025 BE220489 Hs. t 13592 ESTs, Moderately similar to 154374 gene 2. 5 9. 2 414680 AA743331 Hs. 272572 hemoglobin, alpha 2 2. 5 3. 6 429956 A1374651 Hs. 22542 ESTs 2. 5 23. 9 429028 AA443439 Hs. 48797 ESTs 2. 5 2. 8 438109 A1076621 Hs. 71367 ESTs, Moderately similar to ALU7 HUMAN A 2. 5 3. 1 439780 AL109688 db : Homo sapiens mRNA futl length insert 2. 5 2. 3 440888 N45600 Hs. 326880 ESTs 2. 5 3. 9 445246 A1217713 Hs. 147586 ESTs 2. 5 2. 6 440152 AB002376 Hs. 7006 KIAA0378 protein 2. 4 23. 6 432740 AF061034 Hs. 278898 tumor necrosis factor alpha-inducible ce 2. 4 2. 1 415122 D60708 Hs. 22245 ESTs 2. 4 3. 9 432298 AL118812 Hs. 274293 HomosapiensmRNA ; cDNADKFZp761G1111 ( 2. 4 9. 8 437948 AA772920 Hs. 303527 ESTs 2. 4 9. 8 421360 AA297012 Hs. 103839 erythrocyte membrane protein band 4. 1-li 2. 4 2. 8 427115 AW972853 Hs. 112237 ESTs 2. 4 2. 2 452074 BE299035 Hs. 27747 G protein-coupled receptor 37 (endotheii 2. 4 10. 0 436639 D14838 Hs. 111 fibroblast growth factor 9 (glia-acbvat 2. 4 3. 5 434520 AA205273 Hs. 177011 hypothetical protein 2. 4 3. 1 411529 AA430348 Hs. 317596 Homo sapiens CDNA FLJ 12927 fis, clone NT 2. 4 3. 0

442272 AA988302 Hs. 129172 ESTs 2. 4 2. 1 422927 AW247388 Hs. 301423 calcium binding protein 1 (calbrain) 2. 4 2. 7 444647 H14718 Hs. 11506 Human clone 23589 mRNA sequence 2. 4 2. 8 415827 H17462 Hs. 23079 ESTs 2. 4 15. 0 451397 AA017432 Hs. 84529 ESTs, WeaklysimilartoZ202_HUMANZINC 2. 4 3. 9 445200 AA084460 Hs. 12409 somatostatin 2. 4 3. 7 451062 AL110125 Hs. 25910 Homo sapiens mRNA ; cDNADKFZp564C1416 (f 2. 4 2. 4 420328 Y19062 Hs. 96870 staufen (Drosophila, RNA-binding protein 2. 4 4. 3 432122 AA526514 gb : ni60f02. s1 NCl_CGAP_Ov2Homosapiens 2. 4 4. 3 444125 A1124882 Hs. 118121 ESTs 2. 4 3. 5 430538 AB032435 Hs. 242821 differentiation-associated Na-dependent 2. 4 10. 8 457519 X69438 Hs. 3052 early growth response 4 2. 4 2. 4 409371 R51736 Hs. 12381 ESTs 2. 4 2. 1 456303 AA224872 Hs. 115088 ESTs 2. 4 3. 2 440105 AA694010 Hs. 6932 Homosapiensclone23809mRNAsequence 2. 4 23. 4 400979 2. 4 4. 1 435296 R49685 Hs. 24980 ESTs 2. 4 6. 5 408950 AA707814 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 2. 4 18. 5 452032 BE244005 Hs. 27610 reGnoic acid-and interferon-inducible 2. 4 2. 2 432098 AF252297 Hs. 91546 cytochrome P450 retinoid metabolizing pr 2. 4 2. 7 408974 AW015458 Hs. 297017 ESTs 2. 4 2. 5 412177 Z23091 Hs. 73734 glycoprotein V (platelet) 2. 4 2. 8 413153 N94205 gb : za27aO8. r1 Soares fetal liver spleen 2. 4 2. 5 417583 AA668782 Hs. 191284 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 4 2. 6 452034 F12234 Hs. 75893 ankyr 3, node of Ranvier (ankynn G) 2. 3 3. 0 424940 AA985308 Hs. 194327 ESTs 2. 3 6. 3 431706 A1816086 Hs. 296341 adenylyl cyclase-associated protein 2 2. 3 4. 1 419125 AA642452 Hs. 130881 B-cellCLLtiymphoma11A (zinchngerpro 2. 3 2. 9 423641 AL137256 Hs. 130489 ATPase, aminophospholipid transprter-li 2. 3 8. 7 436407 T88803 Hs. 271507 ESTs, Weakly similar to T) M HUMAN PROBAB 2. 3 3. 2 448681 AL109781 Hs. 21754 Homo sapiens MRNA full length insert cDN 2. 3 5. 2 415669 NM005025 Hs. 78589 serine (or cysteine) proteinase inhibito 2. 3 54. 7 410765 A1694972 Hs. 66180 nucleosome assembly protein 1-like 2 2. 3 9. 1 422386 AF105374 Hs. 115830 heparansulfate (glucosamine) 3-0-sulfot 2. 3 5. 0 414828 AA156651 gb : z) 05h05. r1SoarespreQnanLuterusNbH 2. 3 2. 4 445556 A1910241 Hs. 12887 actin-related protein 3-beta 2. 3 8. 5 426968 U07616 Hs. 173034 amphiphysin (Stiff-Mann syndrome with br 2. 3 26. 3 444562 AA186715 Hs. 336429 RlKENcDNA9130422N19gene 2. 3 2. 5 423420 A1571364 Hs. 128382 Homo sapiens mRNA ; cDNA DKFZp76111224 (f 2. 3 7. 6 439450 R51613 Hs. 125304 ESTs 2. 3 26. 3 427127 AW802282 Hs. 22265 pyruvate dehydrogenase phosphatase 2. 3 2. 2 447179 AW015633 Hs. 157299 ESTs 2. 3 3. 8 414711 A1310440 Hs. 288735 Homo sapiens CDNA FU 13522 fis, clone PL 2. 3 2. 3 433449 AW772282 gb : hn71bO5. x1 NCl_CGAP_Kid11 Homosapien Z3 3. 8 414320 U13616 Hs. 75893 ankyr 3, node of Ranvier (ankynn G) 2. 3 2. 5 416778 M16505 Hs. 79876 steroid suHatase (microsomal), arylsulf 2. 3 7. 8 425130 AA448208 Hs. 99163 ESTs 2. 3 4. 1 456664 AW963354 Hs. 334409 metallothionein 1G 2. 3 2. 5 438283 A1458931 Hs. 37282 ESTs 2. 3 4. 2 417455 AW007066 Hs. 18949 ESTs, WeaklysimilartoCA2B_HUMANCOLLA 2. 3 3. 0 412100 AW892731 gb : CMO-NN0005-100300-279-cO2 NN0005 Homo 2. 3 3. 7 448981 A1968719 Hs. 195387 ESTs 2. 3 3. 2 416101 R24854 Hs. 268806 ESTs 2. 3 6. 5 439731 A1953135 Hs. 45140 hypotheGcal protein FU14084 2. 3 17. 8 415734 NM 014747 Hs. 78748 KIAA0237 gene product 2. 3 40. 1 424596 AB020639 Hs. 151017 estrogen-related receptor gamma 2. 3 2. 9 420230 AL034344 Hs. 284186 forehead box C1 2. 3 2. 4 451559 AL119980 Hs. 20935 hypotheGcalprotein DKFZp761D221 2. 3 5. 7 404835 2. 3 2. 1 456765 A1497900 Hs. 33067 ESTs 2. 3 4. 1 455517 AW984068 gb : RCO-HN0006-160300-011-e06 HN0006Homo 2. 3 2. 4 408206 AF041853 Hs. 43670 kinesin family member 3A 2. 2 18. 5 411770 NM 014278 Hs. 71992 heatshockprotein (hsp110family) 2. 2 3. 9 430105 X70297 Hs. 2540 cholinergic receptor, nicotinic, alpha p 2. 2 2. 6 458694 F12832 Hs. 13298 ESTs 2. 2 4. 9 415091 AL044872 Hs. 77910 3-hydroxy-3-methylglutaryl-Coenzyme A sy 2. 2 4. 4 439642 W81441 Hs. 153967 ESTs 2. 2 2. 4 450138 AW152104 Hs. 200879 ESTs 2. 2 4. 9 454222 BE144344 Hs. 7589 ESTs, Weakly similar to A46010 X-linked 2. 2 3. 7 405326 2. 2 2. 7 431342 AW971018 Hs. 21659 ESTs 2. 2 5. 2 453101 AW952776 Hs. 94943 ESTs 2. 2 3. 3 408897 N50204 Hs. 283709 lipopolysaccharide specific response-7 p 2. 2 2. 8 451398 A1793124 Hs. 144479 ESTs 2. 2 4. 6 438208 AL041224 Hs. 65379 ESTs 2. 2 10. 4 408449 NM004408 Hs. 166161 dynamin 1 2. 2 6. 1 414130 A1670831 Hs. 71592 HomosapienscDNA : FLJ21893 fis, clone H 2. 2 3. 1 445016 U79716 Hs. 12246 reetin 2. 2 3. 9 424375 AF070547 Hs. 146312 Homosapiensclone24820mRNAsequence 2. 2 2. 3 424645 NM 014682 Hs. 151449 KIAA0535 gene product 2. 2 11. 7 409729 D51315 Hs. 106289 ESTs 2. 2 4. 9 432809 AA565509 Hs. 131703 ESTs 2. 2 19. 9 422890 Z43784 Hs. 75893 ankyr 3, node of Ranvier (ankyrin G) 2. 2 10. 4

428532 AF157326 Hs. 184786 TBP-interæUng protein 2. 2 6. 5 413074 Api871368 Hs. 8417 hypothetical protein DKFZp761M0423 2. 2 3. 4 414442 AA156238 Hs. 32501 ESTs 2. 2 3. 2 452768 AW069459 Hs. 61539 ESTs 2. 2 2. 0 450440 AB024334 Hs. 25001 tyrosine 3-monooxygenase/tryptophan 5-mo 2. 2 3. 2 426281 AK000987 Hs. 1691 11 oxidafion resistance 1 2. 2 2. 3 428411 AW291464 Hs. 10338 ESTs 2. 2 2. 3 413787 A1352558 Hs. 75544 tyrosine 3-monooxygenase/tryptophan Smo 2. 2 3. 1 451734 NM006176 Hs. 26944 neurogranin (protein kinase C substrate, 2. 2 8. 5 439108 AW163034 Hs. 6467 synaptogyrin 3 2. 2 7. 9 405385 2. 2 2. 4 447285 Al371849 Hs. 200696 ATPase, Class VI, type 11C 2. 2 2. 2 452667 T87219 Hs. 13219 ESTs 2. 2 3. 1 422234 AF119818 Hs. 113287 discs, large (Drosophila) homolog-associ 2. 1 8. 3 410339 A1916499 Hs. 298258 ESTs 2. 1 3. 2 413231 D87461 Hs. 75244 BCL2-like 2 2. 1 4. 5 447104 R19085 Hs. 210706 HomosapienscDNAFW13182fis, cloneNT 21 22 451952 AL120173 Hs. 301663 ESTs 2. 1 36. 5 415841 Z45637 Hs. 7093 ESTs 2. 1 2. 4 441086 Al928489 Hs. 213490 ESTs, Weakly similar to N33 HUMAN N33 PR 2. 1 2. 2 450407 NM 000810 Hs. 24969 gamma-aminobutyricacid (GABA) A recepto 2. 1 6. 6 427627 R87582 Hs. 179915 guanine nucleotide binding protein (G pr 2. 1 5. 3 449712 R56545 Hs. 6100 ESTs 2. 1 4. 5 409660 AW452065 Hs. 258905 ESTs 2. 1 2. 1 430434 AL049548 Hs. 241420 Homo sapiens MRNA for KIAAI 756 protein, 2. 1 5. 4 434138 AA625804 gb : zu86hO1. s1 Soares_tes6s_NHTHomosap 2. 1 3. 0 448610 NM 006157 Hs. 21602 net (chicken)-like 1 2. 1 4. 8 418948 Api217097 gb : qd43hO7. x1 Soares_fetá_heatNbHH19W 2. 1 2. 9 414876 AW950925 Hs. 924 crystallin, mu 2. 1 3. 4 440426 Api159800 Hs. 7181 Homo sapiens cDNA FLJ13663 fis, clone PL 2. 1 3. 7 451249 AA016227 Hs. 27280 ESTs 2. 1 4. 1 451475 T19093 Hs. 26450 KIAA0725 protein 2. 1 2. 1 448743 AB032962 Hs. 21896 KlM1136protein 2. 1 29. 7 430814 U89336 Hs. 247993 NG5 protein 2. 1 2. 7 426990 AL044315 Hs. 173094 Homo sapiens mRNA for KIAA1750 protein, 2. 1 2. 3 426642 AW068223 Hs. 171581 ubiqui6n C-temminal hydroiase UCH37 2. 1 4. 5 427335 AA448542 Hs. 251677 G antigen 7B 2. 1 2. 2 459089 F13036 Hs. 27373 Homo sapiens mRNA ; cDNA DKFZp56401763 (f 2. 1 2. 3 435832 AA425688 Hs. 41641 Bruno (Drosophila)-like 4, RNA binding 2. 1 5. 9 446383 T05816 Hs. 92511 ESTs 2. 1 2. 9 412768 AW996044 Hs. 26239 HumanDNAsequencefromcloneRP11438B2 2. 1 2. 1 453976 BE463830 Hs. 163714 ESTs 2. 1 4. 2 415111 R39039 Hs. 328455 EST 2. 1 3. 3 452238 F01811 Hs. 187931 ESTs 2. 1 4. 9 445279 R41900 Hs. 22245 ESTs 2. 1 9. 8 448799 A1937094 Hs. 179080 ESTs 2. 1 3. 1 418338 NM 002522 Hs. 84154 neuronal pentraxin 1 2. 1 8. 3 445725 AK000956 Hs. 13209 hypothetical protein FW10094 2. 1 5. 4 443537 D13305 Hs. 203 cholecystokinin B receptor 2. 1 4. 1 454066 X00356 Hs. 37058 catcitonin/calcitonin-related polypep6d 2. 1 6. 4 429954 A1918130 Hs. 21374 ESTs 2. 1 7. 2 415292 H29016 Hs. 200576 ESTs 2. 1 3. 9 423563 R34734 Hs. 75209 protein kinase (cAMP-dependent, catalyti 2. 1 3. 1 424906 A1566086 Hs. 153716 Homo sapiens mRNA for Hmob33 protein, 3'2. 1 4. 7 459309 AA040620 Hs. 5672 hypothe6calproteinAF140225 2. 1 2. 2 439340 AB032436 Hs. 6535 brain-specific Na-dependent inorganic ph 2. 1 4. 7 402598 BE314624 Hs. 3128 polymerase (RNA) lt (DNA directed) polyp 2. 1 5. 4 435406 F26698 Hs. 4884 calcium/calmodulin-dependent protein kin 2. 1 6. 6 448792 R42550 Hs. 12826 ESTs 2. 1 4. 1 449500 AW956345 Hs. 12926 ESTs 2. 1 2. 4 441134 W29092 Hs. 7678 cellular retinoic acid-binding protein 1 2. 1 5. 8 433361 AW469373 Hs. 300141 ribosomal protein L39 2. 1 2. 7 452946 X95425 Hs. 31092 EphA5 2. 1 5. 0 426167 AF039023 Hs. 167496 RAN binding protein 6 2. 0 2. 2 453666 AW015681 Hs. 135229 ESTs, Weakty similar to A2BP_HUMAN ATAXI 2. 0 3. 1 424632 AB014523 Hs. 151406 KIAA0623 gene product 2. 0 3. 5 448589 AF017090 Hs. 21554 KIAA1107 protein 2. 0 4. 1 430416 AC005531 Hs. 57806 Homo sapiens PAC clone RP4-701016 from 7 2. 0 2. 3 445627 AW818475 Hs. 7363 ESTs 2. 0 2. 1 417092 H97508 Hs. 181165 eukaryotic translation elongation factor 2. 0 2. 5 453653 AW505554 Hs. 144559 ESTs 2. 0 4. 7 435850 AF250847 Hs. 283514 mitochonddal ceramidase 2. 0 3. 7 435086 AW975243 Hs. 122596 ESTs 2. 0 2. 1 423191 D61506 Hs. 8417 hypothetical protein DKFZp761M0423 2. 0 2. 1 411562 AL050201 Hs. 70769 hypothefical protein DKFZp586E1923 2. 0 2. 8 431645 AF078849 Hs. 266483 dynein light chain-A 2. 0 2. 5 429834 A1929645 Hs. 225936 synapsin 1 2. 0 3. 6 439607 BE540565 Hs. 159460 ESTs 2. 0 17. 5 408033 AW138045 Hs. 242256 ESTs 2. 0 4. 0 430317 AB020645 Hs. 239189 glutaminase 2. 0 2. 7 419631 AW188117 Hs. 303154 popeye protein 3 2. 0 2. 6 432660 A1288430 Hs. 64004 ESTs 2. 0 2. 3 454048 H05626 Hs. 6921 ESTs 2. 0 15. 9

426917 AA913814 Hs. 172854 DKFZP586B0923 protein 2. 0 3. 1 423246 AL119114 Hs. 77196 spectnn, åpha, non-erythnDcy6c 1 (alp 2. 0 2. 9 415989 A1267700 Hs. 317584 ESTs 2. 0 4. 8 420276 AA290938 Hs. 190561 ESTs, Highly similar to SORL_HUMAN SORTI 2. 0 5. 1 424983 Api742434 Hs. 169911 ESTs 2. 0 15. 9 446296 AA985662 Hs. 63131 Homo sapiens CDNA FU 13155 fis, clone NT 2. 0 2. 7 450006 A1241555 Hs. 60171 ESTs 2. 0 3. 5 TABLE 11B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408274 104999 R17315Z43964AA053547 412100 1277224_1 AW892731 H08502Z45826 412112 1277883-1 BE180342 BE180347 AW901900 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE180228AW901897 BE180224 AW901898 BE180223 BE180219 BE180346 BE180343 BE180418 BE180225 BE180221 BE180341 AW901894 BE180217 BE180227 AW901891 BE180345 AW893614 AW893615 H85799 H83501 BE180220 413153 1350849_1 N94205 BE067565 BE067556 413510 1374377_1 F13044 T77009 BE145525 BE145493 414828 149563_1 M156651 M156622 R14472 418948 180808_1 Al217097 AW856090 W38035 W38792 M232835 AW936043 419558 185904 1 AW953679 AW953680 AA244436 H82527 AA361046 AA244483 H82526 421249 20064991 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204833_1 AW966652 AW966653 M294989 M385977 429995 311738_1 M463571 A1277645AL118763 430212 314437_1 AA469153 A1718503 AA469225 432122 341756 1 AA526514 AW973343 AA554293 433449 366532 1 AW772282 AA592974 434138 380572 1 AA625804 AW418787 AW074833 A1675642 AI393368 437483 43756_1 AL390174 AW898817 439780 47673_1 AL109688 R23665 R26578 452502 919733_1 Al904296 BE007223 R30687 455517 13217821 AW984068 AW984072 AW984077 456407 184986_1 AW968614M243209M281411 TABLE 11C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Iden6her (Gl) numbers. Dunham, et al. * refers to the publication entitled The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. NtjMSition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_psiton 400979 8072554 Plus 160842-161028 401213 9858408 Plus 98243-98380, 98489-98619 401421 7452889 Minus 142291-142461 403092 8954241 Plus 174720-175016, 175104-175406, 175508-175813 404648 9796894 Minus 115334-116020 404793 7232206 Minus 61087-61590 404835 6970743 Plus 85462-85684, 8813388287, 90338-91018, 94827-94990 405326 4375975 Plus 10633-10709, 3080530893, 38078-38253, 55112-55327, 5771&57818, 66696-66841 405385 6552772 Plus 48332-48454 405793 1405887 Minus 89197-89453 405911 6758795 Plus 101008-101643 405977 8247789 Minus 135548-136177 TABLE 12A : ABOUT 678 GENES UP-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL CENTRAL NERVOUS SYSTEM Table 1 2A lists about 678 genes up-regulated in lower grade glioblastoma (LGG) compared to normal central nervous system (CNS). These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average"LGG to'average'CNS tissues was greater than or equal to 2. 5. The average-LGG level was set to the 85* percentile amongst various LGG tumors. The'average'normal CNS tissue level was set to the 85tb percen61e amongsl va ious CNS tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10"'percentile vaiue amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of LOWER GRADE GLIOBLASTOMA to normal CNS Pkey ExAccn UnigenelD Unigene Tiüe R1 412420 AL035668 Hs. 73853 bone morphogenetic protein 2 20. 3 424800 AL035588 Hs. 153203 MyoD family inhibitor 19. 5 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 18. 5 402604 Target Exon 16. 9 444190 A1878918 Hs. 10526 cysteine and glycine-rich protein 2 15. 0 409638 AW450420 Hs. 21335 ESTs 14. 0 443731 A1083928 Hs. 145418 ESTs 14. 0 456759 BE259150 Hs. 127792 delta (Drosophila)-like 3 13. 6 447342 A1199268 Hs. 19322 Homosapiens, SimilartoRIKENCDNA2010 12. 2 433001 AF217513 Hs. 279905 clone H00310 PR00310p1 10 3 427019 AA001732 Hs. 173233 hypotheticalproteinFFJ10970 9. 5

425187 AW014486 Hs. 22509 ESTs 9. 0 440210 AW674562 Hs. 125296 ESTs 8. 8 448769 N66037 Hs. 38173 ESTs 8. 4 437034 AA742643 gb : ny91c01. s1 NCI_CGAP_GCB1 Homosapiens 8. 2 449539 W80363 Hs. 58446 ESTs 8. 1 417061 A1675944 Hs. 188691 Homo sapiens cDNA FW12033 hs, cbne HE 8. 0 435020 AW505076 Hs. 301855 DiGeorge syndrome critical region gene 8 7. 8 414217 AI309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 7. 7 449300 A1656959 Hs. 346514 ESTs 7. 6 449969 AW295142 Hs. 180187 Homo sapiens cDNA FLJ 14337 ñs, cbne PL 7. 5 452372 A1885742 Hs. 228474 ESTs 7. 2 410102 AW248508 Hs. 279727 ESTs : homologue of PEM-3 [Ciona savignyi 7. 2 417308 H60720 Hs. 81892 KIAA0101 gene product 7. 2 447004 AW296968 Hs. 157539 ESTs 7. 1 418113 Api272141 Hs. 83484 SRY (sex determining region Y)-box 4 7. 1 424635 AA420687 Hs. 115455 Homo sapiens cDNA FLJ14259 fis, clone PL 7. 1 406478 Target Exon 7. 1 428728 NM016625 Hs. 191381 hypothetical protein 6. 9 414761 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homolog2 6. 9 428037 N47474 Hs. 89230 potassium intermediate/small conductance 6. 7 423343 AA324643 Hs. 246106 ESTs 6. 7 418097 R45137 Hs. 21868 ESTs 6. 7 431553 X78075 Hs. 2799 cartilage linking protein 1 6. 6 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 6. 6 425397 J04088 Hs. 156346 topoisomerase (DNA) tia) pha (170kD) 6. 4 419169 AW851980 Hs. 262346 ESTs, Weakly similar to S72482 hypothe6 6. 4 431117 AF003522 Hs. 250500 delta (Drosophila)-like 1 6. 4 445908 R13580 Hs. 13436 Homosapiensclone24425mRNAsequence 6. 3 402855 NM001839' : Homo sapiens calponin 3, acid 6. 2 424009 F11690 gb : HSC30D041 normalized infant brain cDN 6. 2 400419 AF084545 Target 6. 2 446584 U53445 Hs. 15432 downregulated in ovarian cancer 1 6. 0 414020 NM 002984 Hs. 75703 small inducible cytokine A4 (homologous 6. 0 426140 AF131798 Hs. 343768 Homosapiensclone25119mRNAsequence 5. 9 427144 X95097 Hs. 2126 vasoac6veintes6nalpep6de receptor 2 5. 9 416658 U03272 Hs. 79432 fibrillen 2 (congenital contractural ara 5. 8 405238 Target Exon 5. 7 421977 W94197 Hs. 110165 ribosomal prolein L26 homolog 5. 7 405348 C7001664 : gil12698061ldbjlBAB21649. 1l (AB 5. 6 428795 R45503 Hs. 97469 ESTs, Highly similar to A39769 N-acetyll 5. 4 422672 X12784 Hs. 119129 collagen, type IV, alpha 1 5. 3 403349 NM 001406 ephrin-B3 5. 3 453941 U39817 Hs. 36820 Bloom syndrome 5. 2 429139 F09092 Hs. 66087 ESTs 5. 2 454860 AW835767 gb : QV4-LT0016-240200-110-b08LT0016Homo 5. 2 452279 AA286844 Hs. 61260 hypothetical protein FLJ13164 5. 1 418030 BE207573 Hs. 83321 neuromedin B 5. 1 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxyla6ng ; 5. 1 450639 A1703186 Hs. 277174 ESTs 5. 1 412811 H06382 ESTs 5. 1 442832 AW206560 Hs. 253569 ESTs 5. 1 436608 AA628980 down syndrome critical region protein DS 5. 1 408161 AW952912 Hs. 300383 hypothetical protein MGC3032 5. 1 443744 A1084326 Hs. 27 1548 ESTs, Weakly similar to 178885 serine/th 5. 1 447497 AW167254 Hs. 205722 ESTs 5. 0 450811 Al739486 Hs. 245497 ESTs 5. 0 433244 AB040943 Hs. 271285 KIAA1510 protein 4. 9 438458 AW975186 gb : EST387294 MAGE resequences, MAGN Homo 4. 9 438456 AA913381 Hs. 20594 ESTs 4. 9 411048 AK001742 Hs. 67991 hypolhetical protein DKFZp434G0522 4. 9 456304 A1820973 gb : nc21cO2. y5 NCl_CGAP_Pr1 Homo sapiens 4. 9 442547 AA306997 Hs. 217484 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 9 419991 AJ000098 Hs. 94210 eyes absent (Drosophila) homolog 1 4. 8 402274 C19000498-: gil4567179lgblMD23607. 1 ACOO 4. 8 420092 AA814043 Hs. 88045 ESTs 4. 8 436282 R91913 Hs. 272104 ESTs, Moderately similar to ALU1 HUMAN A 4. 8 430809 Api791150 Hs. 262009 ESTs, Moderately similar to 138022 hypot 4. 8 455104 BE064863 gb : RC1-BT0313110300-O15. f06 BT0313 Homo 4. 8 403961 Target Exon 4. 8 424954 NM000546 Hs. 1846 tumor protein p53 (Li-Fraumeni syndrome) 4. 8 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 4. 8 447891 R41754 Hs. 6496 ESTs 4. 7 423529 T87318 Hs. 120411 ESTs 4. 7 422737 M26939 Hs. 119571 collagen, type lil, alpha 1 (Ehlers-Danl 4. 7 428722 U76456 Hs. 190787 tissue inhibitor of metalloproteinase 4 4. 6 437698 R61837 Hs. 7990 ESTs. Moderately similar to 184505 calci 4. 6 403481 Target Exon 4. 6 426075 AW513691 Hs. 270149 ESTs, Weakly similar to 2109260A B cell 4. 6 422170 A1791949 Hs. 112432 anli-Mullenanhomlone 4. 6 416379 N38857 Hs. 203933 ESTs 4. 6 406481 Target Exon 4. 5 456052 BE311901 Hs. 28935 gb : 601142614F1 NIH MGC 14 Homo sapiens c 4. 5 423178 A1033140 Hs. 124983 Homo sapiens mRNA ; cDNA DKFZp564C142 (fr 4. 5

411642 NM014932 Hs. 71132 neuroligin 1 4. 5 428282 N34905 Hs. 44653 Homo sapiens cDNA : FU22669 fis, clone H 4. 5 432625 A1243596 Hs. 94830 ESTs Moderately similar to T03094 A-kin 4. 5 452994 AW962597 Hs. 31305 KIAAL 547 protein 4. 5 449961 AW265634 Hs. 133100 ESTs 4. 4 401454 NM 014226-: Homosapiensenaltumoranti 4. 4 406395 Target Exon 4. 4 432281 AK001239 Hs. 274263 hypothetical protein FU10377 4. 4 453792 AL134539 Hs. 254129 KIAA1678 4. 4 415131 D61119 gb : HUM158C11BOontechhumanfetalbrain 4. 4 437695 AA769202 Hs. 192142 ESTs 4. 4 422081 AW136820 Hs. 196011 ESTs 4. 4 437748 AF234882 Hs. 5814 suppression of tumorigenicity 7 4. 3 433323 AA805132 Hs. 159142 ESTs 4. 3 420352 BE258835 gb : 601117374Ft NIH MGC 16 Homo sapiens c 4. 3 444218 AF070641 Hs. 10684 Homo sapiens clone 24421 mRNA sequence 4. 3 441035 A1694309 Hs. 126458 ESTs 4. 3 443836 BE221613 Hs. 140553 ESTs 4. 3 425292 Nom005824 Hs. 155545 37 kDa leucine-dch repeat (LRR) protein 4. 3 450166 AA429504 ESTs 4. 3 429149 AW193360 Hs. 197962 ESTs Weakly similar to 138022 hypotheb 4. 2 422798 R92347 Hs. 34574 ESTs. WeaklysimilarloALU1_HUMiANALU S 4. 2 451254 A1571016 Hs. 172967 ESTs 4. 2 409189 AA125984 gb : zn27hO6. r1 Stratagene neuroepithelium 4. 2 445118 A1208762 Hs. 345572 ESTs 4. 2 444326 A1939357 Hs. 270710 ESTs 4. 2 456060 C14904 Hs. 45184 Homo sapiens cDNA FU12284 fis, clone MA 4. 2 404120 C5000537* : gil32985951gblAAC41376. 11 (AFO 4. 2 436899 AA764852 Hs. 291567 ESTs 4. 1 407624 AW157431 Hs. 248941 ESTs 4. 1 453361 AA035197 Hs. 107375 ESTs 4. 1 447439 AA313565 Hs. 145020 ESTs Weakly similar to KIAA1205 protein 4. 1 438372 A1140189 Hs. 123191 ESTs 4. 1 438624 AA889055 Hs. 123468 ESTs 4. 1 422493 AW474183 Hs. 250173 hypothetical protein FU13158 4. 1 406872 A1760903 gb : wiO9hO8. x1 NCI_CGAP CLL1 Homosapiens 4. 1 425295 AA431366 Hs. 37251 ESTs 4. 1 425849 AJ000512 Hs. 296323 senum/glucocor6coidrevqulatedUnase 4. 1 434206 AW136973 Hs. 180479 ESTs Weakly similar to S69890 mitogen i 4. 0 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 4. 0 400645 Target Exon 4. 0 456306 AA225313 Hs. 222886 ESTs WeakysimilartoTRHY_HUMANTRICH 4. 0 419326 W94915 Hs. 42419 ESTs 4. 0 414948 C15240 Hs. 182155 ESTs 4. 0 423198 M81933 Hs. 1634 cell division cycle 25A 4. 0 411537 BE073250 gb : MRO-BT0551-060300-102-eOSBT0551 Homo 4. 0 421637 AF035290 Hs. 106300 Homo sapiens clone 23556 mRNA sequence 3. 9 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 3. 9 429433 AA452899 Hs. 213586 ESTs. Weakly similar to KIAAI 353 protein 3. 9 424186 A1536021 Hs. 288706 HomosapienscDNAFLJ10281fis cloneHE 3. 9 449932 A1675444 Hs. 263024 ESTs 3. 9 434072 H70854 Hs. 283059 Homo sapiens PR01082 mRNA, complete cds 3. 9 434784 AA649051 Hs. 164007 ESTs 3. 9 425146 AW954627 gb : EST366697 MAGE resequences, MAGC Homo 3. 9 428538 AA446440 Hs. 98643 ESTs 3. 9 443318 A1051603 Hs. 133141 ESTs 3. 9 416857 AA188775 Hs. 292453 ESTs 3. 9 411688 AW953440 gb : EST365510 MAGE resequences, MAGB Homo 3. 9 447343 AA256641 Hs. 236894 ESTs Highly similar to S02392 alpha-2-m 3. 9 425905 AB032959 Hs. 318584 novelC3HC4typeZinchnger (nnghnge 3. 8 403696 C4001 100* : gil58523421gblAAD54015. 11 (AFO 3. 8 415884 H22966 Hs. 13471 ESTs 3. 8 432646 AW753310 gb : RC3-CT0254-031099-012-c05 CT0254 Homo 3. 8 447057 A1423407 Hs. 157697 ESTs 3. 8 400814 Target Exon 3. 8 441329 A1203575 Hs. 46821 hypothetical protein FU20086 3. 8 416664 H72780 Hs. 20289 ESTs 3. 8 426044 AA502490 Hs. 170290 ESTs 3. 8 455646 BE064420 gb : RC4-BT0311-241199-012-cO8BT0311 Homo 3. 8 419043 T19167 Hs. 89566 etsvahantgenet 18 445075 A1651827 Hs. 344767 ESTs 3. 8 457211 AW972565 Hs. 32399 ESTs Weakly similar to S51797 vasodilat 3. 8 420004 AW975532 Hs. 164039 ESTs Moderately similar to 138022 hypot 3. 8 428060 AA420616 Hs. 249483 ESTs 3 7 416427 BE244050 Hs. 79307 Rac/Cdc42 guanine exchange factor (GEF) 3. 7 453038 AW292415 Hs. 20509 HBV pX associated protein-8 3. 7 404584 Target Exon 3. 7 447143 AW292408 Hs. 152290 ESTs HighlysimilartoJC2463vasoæUv 37 453438 A1469935 Hs. 22792 ESTs 3 7 429643 AA455889 Hs. 167279 FYVE-finger-containing Rab5 effector pro 3. 7 458072 A1890347 Hs. 271923 Homo sapiens cDNA : FW22785 hs ctone K 3. 7 459660 M79082 ESTs 3 7 432188 A1362952 Hs. 2928 solute carrier family 7 (cationicamino 3. 7

430744 AA485229 Hs. 105649 ESTs 3. 7 454392 BE260893 Hs. 236131 homeodomain-interæUng protein kinase 2 3. 7 454457 AW753456 gb : QV2-CT0261-261099-011-dti CT0261 Homo 3. 7 435095 AA021160 Hs. 4750 hypothetical protein OKFZp564KO822 3. 7 438206 AA780385 Hs. 187885 ESTs 3. 7 418967 NM001725 Hs. 89535 bactericidaUpenneability-increasing pro 3. 7 427809 M26380 Hs. 180878 lipoprotein lipase 3. 7 427722 AK000123 Hs. 180479 hypothetical protein FU20116 3. 7 413986 Z43567 gb : HSC1FC021 normalized infant brain cDN 3. 7 438898 Api819863 Hs. 106243 ESTs 3. 7 418483 W26076 Hs. 221847 ESTs 3. 7 415849 R20529 Hs. 6806 ESTs 3. 6 438380 T06430 Hs. 6194 chondroitinsu) sulfate proteoglycan BEHAB/b 3. 6 440296 D30829 Hs. 180610 splicing factor prolinelglutamine rich (3. 6 438025 AW501360 Hs. 258910 ESTs 3. 6 458970 AW246119 Hs. 25300 phospha6dylinosilol4-kinasetypell 3. 6 448002 Y15227 Hs. 20149 deleted in IymphocyUc leukemia, 1 3. 6 432058 AW665996 Hs. 130729 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 6 409557 BE182896 Hs. 211193 ESTs 3. 6 418049 AA211467 Hs. 190488 Homosapiens, Similartonuclearbcaliz 3. 6 425331 AW962128 gb : EST374201 MAGE resequences, MAGG Homo 3. 6 424051 AL110203 Hs. 138411 HomosapiensmRNA ; cDNA DKFZpS86J 1922 (f 3. 6 404185 Target Exon 3. 6 427517 AA644142 Hs. 7107 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 6 421094 AW978202 Hs. 289064 hypothetical protein FU22251 3. 6 440388 A1693520 Hs. 223000 ESTs 3. 6 415934 Nom-000928 Hs. 992 phospholipaseA2, gnouplB (panceas) 3. 6 408292 AW178363 gb : RC3-HT0105-010999-002-HO6 HT0105 Homo 3. 6 442432 BE093589 Hs. 38178 hypothetical protein FU23468 3. 6 451826 AA020741 Hs. 171611 ESTs 3. 6 427375 AL035460 Hs. 177536 metallocarboxypeptidase CPX-1 3. 6 419485 AA489023 Hs. 99807 ESTs, Weakly similar to unnamed protein 3. 6 416370 N90470 Hs. 203697 ESTs, Weakly similar to 138022 hypotheti 3. 6 418400 BE243026 Hs. 301989 KIAA0246 protein 3. 6 436674 AA725002 Hs. 272018 low molecular mass ubiquinone-binding pr 3. 5 407013 U35637 gb : HumannebutinmRNA, parUalcds 3. 5 403108 ENSP00000241415' : Hypothetical 67. 7 kDa p 3. 5 422564 A1148006 Hs. 222120 ESTs 3. 5 450297 AW901347 Hs. 38592 hypothetical protein FU23342 3. 5 436338 W92147 Hs. 118394 ESTs 3. 5 447458 A1741082 Hs. 158961 ESTs 3. 5 457364 AW971037 gb : EST383123 MAGE resequences, MAGK Homo 3. 5 458814 At498957 Hs. 170861 ESTs, Weakly similar to 1195_HUMAN ZINC 3. 5 441701 AW339828 Hs. 127497 ESTs 3. 5 405558 Target Exon 3. 5 452682 AA456193 Hs. 9071 progesterone membrane binding protein 3. 5 434589 AF147363 gb : Homo sapiensfull length insert cDNA 3. 5 443282 T47764 Hs. 132917 ESTs 3. 5 405183 NM016358' : Homo sapiens iroquois homeobo 3. 5 410064 X53416 Hs. 195464 filamin A, alpha (actin-binding protein-3. 5 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypothefi 3. 5 404272 Target Exon 3. 5 428808 AA436007 Hs. 188780 ESTs 3. 5 447444 AK000318 Hs. 18616 hypothetical protein FLJ20311 3. 5 450475 AW805634 Hs. 205015 ESTs 3. 4 454451 AW846706 gb : QV3-CT0192-211099-008-gO2 CT0192 Homo 3. 4 400379 NM018432 Homo sapiens ovarian cancer related prot 3. 4 440948 AW188311 Hs. 128619 ESTs 3. 4 449611 A1970394 Hs. 197075 ESTs 3. 4 445666 R59960 Hs. 282386 ESTs 3. 4 445828 F05802 Hs. 81907 ESTs 3. 4 437528 N59646 Hs. 169745 crumbs (Drosophila) homolog 1 3. 4 442927 A1024347 Hs. 131519 ESTs 3. 4 451130 A1762250 Hs. 345554 ESTs 3. 4 454765 AW819629 gb : RCSST0293-140200-014-H05 ST0293 Homo 3. 4 459200 Y09306 Hs. 30148 homeodomain-interacbng protein kinase 3 3. 4 433791 AA719352 Hs. 112718 ESTs 3. 4 444911 U06117 Hs. 250 xanthenedehydrogenase 3. 4 439753 BE262233 Hs. 7423 hypothetical protein from EUROIMAGE 2168 3. 4 440933 A1208217 Hs. 142879 ESTs 3. 4 447726 AL137638 Hs. 19368 matrilin 2 3. 4 403849 Target Exon 3. 4 422418 AK001383 Hs. 116385 hypothetical protein FLJ10521 3. 3 439533 W76021 gb : zd64c04. ri Soaresfetal heartNbHH19W 3. 3 416422 H60457 ESTs, ModeralelysimilartoZN91_HUMANZ 3. 3 441668 A1611973 Hs. 136313 ESTs 3. 3 432890 NM 014442 Hs. 279751 sialic acid binding Ig-like lectin 8 3. 3 412135 AW895309 gb : QV4-NN0038-300300-15507NN0038Homo 3. 3 417130 AW276858 Hs. 81256 S100 calcium-binding protein A4 (calcium 3. 3 447854 AW138454 Hs. 11594 ESTs 3. 3 448048 BE281291 Hs. 170408 ESTs, Moderately similar to A47582 B-cel 3. 3 404632 NM022490 : Homo sapiens hypothetical prot 3. 3 411565 AW851728 gb : MR2-CT0222-011199-007-dO6CT0222Homo 3. 3

436267 AW450938 Hs. 180115 ESTs 3. 3 426625 T78300 Hs. 300642 serologically defined colon cancer antig 3. 3 401272 C9000559-: gij123141951emblCAB99338. 1l (A 3. 3 433128 AB021923 Hs. 23367 EST-YD1 prolein 3. 3 401702 NM_001171-: Homo sapiens ATP-binding cass 3. 3 454363 AW816274 Hs. 250154 hypothetical protein FLJ12973 3. 3 440332 A1218517 Hs. 188051 ESTs 3. 3 454177 AW807321 gb : MR4-ST0062-240300-003-g05 ST0062 Homo 3. 3 423784 AK000039 Hs. 132826 Homo sapiens cDNA FLJ14913 fis, clone PL 3. 3 440688 AW404591 Hs. 147440 ESTs, Weakly similarto Z192_HUMAN ZINC 3. 3 410267 AW978005 Hs. 12600 N-ethylmaleimide-sensiGve factor attach 3. 3 455778 BE088746 gb : CM2-BT0693-210300-123-dO9 BT0693 Homo 3. 3 430183 BE010038 gb : PM3-BN0176-100400-001-g04BN0176Homo 3. 2 451597 AW295250 Hs. 207536 ESTs 3. 2 451446 A1826288 Hs. 171637 hypothetical protein MGC2628 3. 2 421353 AW292857 Hs. 255130 ESTs 3. 2 442710 A1015631 Hs. 23210 ESTs 3. 2 420560 AW207748 Hs. 59115 ESTs 3. 2 417404 NM007350 Hs. 82101 pleckstrinhomology-likedomån, family 3. 2 437834 AA769294 Hs. 283854 gb : nz36g03. s1 NCI CGAP GCB1 Homo sapiens 3. 2 430694 AA810624 Hs. 30936 ESTs, Weakly similar to H2BH_HUMAN HISTO 3. 2 412021 AW885592 gb : RC4-OT0071-090300-011-g11 OT0071 Homo 3. 2 443431 Al056847 Hs. 20654 ESTs 3. 2 445774 A1254165 Hs. 339968 ESTs 3. 2 413335 A1613318 Hs. 48442 ESTs 3. 2 450692 H50603 Hs. 94037 hypothetical protein FU23053 3. 2 411671 BE049094 ESTs 3. 2 404592 NM022739* : Homo sapiens E3 ubiqui6n lig 3. 2 402747 Target Exon 3. 2 428600 AW863261 Hs. 242413 hypotheGcalprotein DKFZp434K1421 3. 2 420300 AA258245 Hs. 127573 Homo sapiens FKSG41 (FKSG41) mRNA, compl 3. 2 445347 AF035318 Hs. 12533 Homosapiensclone23705mRNAsequence 3. 2 458438 Api141520 Hs. 151464 ESTs, WeaklysimilarloALUC_HUMAN ! ! ! ! 3. 2 442314 A1311854 Hs. 129220 ESTs 3. 2 436291 BE568452 Hs. 344037 proteinregulatorofcytokinesis 1 3. 2 413249 AF167160 Hs. 75251 DEAD/H (Asp-Glu-Ala-Asp/His) box binding 3. 2 448789 BE539108 Hs. 22051 hypothetical protein MGC15548 3. 2 403291 Target Exon 3, 2 436210 Al825420 Hs. 197824 ESTs 3. 2 418079 R40058 Hs. 6911 ESTs 3. 2 413951 AW051200 Hs. 75640 natriurefic pepbde precursor A 3. 2 435828 AA700705 Hs. 13852 ESTs 3. 2 437722 AW292947 Hs. 122872 ESTs, Weakly similar to JU0033 hypotheti 3. 2 451418 BE387790 Hs. 26369 hypothetica) protein FLJ20287 3. 2 405046 C3000978 : gil9280045jdbjlBABO1579. 1l (ABO 3. 1 444315 R07860 Hs. 20039 ESTs 3. 1 453096 AW294631 Hs. 11325 ESTs 3. 1 433835 Api806185 gb : wf26a10. x1 Soares_NFL_T_GBC_S1 Homo s 3. 1 430608 R45584 Hs. 23025 ESTs, Weakly similar to ALU5_HUMAN ALU S 3. 1 453324 W26592 Hs. 232089 ESTs 3. 1 414884 R54418 Hs. 183745 hypothetical protein FLJ13456 3. 1 446862 AV660697 Hs. 282700 ESTs 3. 1 427241 AA399988 Hs. 112087 HumanDNAsequencefromcloneRP11-530N1 3. 1 416486 H81336 Hs. 37560 ESTs 3. 1 429940 W25215 gb : zb87aO9. r1 Soaes_senesceniffibroblas 3. 1 430535 AW968485 gb : EST380561 MAGE resequences, MAGJ Homo 3. 1 439544 W26354 Hs. 28891 hypotheUcalproteinFW11360 ; artemisp 3. 1 437083 AW082597 Hs. 244862 ESTs 3. 1 435677 AA694142 Hs. 293726 ESTs, Weakly similar to TSGA RAT TESTIS 3. 1 458810 BE407125 Hs. 231510 ESTs 3. 1 443484 A1091458 Hs. 134559 ESTs 3. 1 427581 NM 014788 Hs. 179703 KIAA0129 gene product 3. 1 444016 AA448154 gb : zw82hO9. r1SoarestestisNHT Homo sap 3. 1 423337 NM_004655 Hs. 127337 axin 2 (conduc6n, axil) 3. 1 403288 C1001737* : gil75112011pirlIT27904 hypothe 3. 1 450125 AA005418 Hs. 158186 ESTs 3. 1 438138 R98299 Hs. 177502 ESTs 3. 1 436222 Api208737 Hs. 122810 Homo sapiens cDNA FLJ11489 fis, clone HE 3. 1 443433 R44743 Hs. 301667 ESTs 3. 1 443725 AW245680 Hs. 9701 growth arrest and DNA-damage-inducible, 3. 1 432044 AW972727 gb : EST384819 MAGE resequences, MAGL Homo 3. 1 405760 Target Exon 3. 1 423789 AK002084 Hs. 132851 hypotheficai protein FU 11222 3. 1 411605 AW006831 Hs. 177530 ESTs 3. 1 417893 AA290605 Hs. 190002 ESTs 3. 1 449246 AW411209 Hs. 23363 hypotheticai protein FLJ10983 3. 1 429528 A1985303 Hs. 99361 ESTs 3. 1 456645 AF227156 Hs. 110103 RNA polymerase I transcrip6on factor RR 3. 1 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 3. 1 421679 A1475110 Hs. 203933 ESTs 3. 1 434503 T96231 Hs. 17762 ESTs 3. 1 450756 A1733488 Hs. 144062 ESTs 3. 1 415293 R49462 Hs. 106541 ESTs 3. 0

403212 NM019595 : Homo sapiens intersectin 2 (IT 3. 0 422757 A1909935 Hs. 65551 Homo sapiens, Similar to DNA segment, Ch 3. 0 427624 AA406245 Hs. 24895 ESTs 3. 0 449256 AA059050 Hs. 59847 ESTs 3. 0 411543 AW851248 gb : lL3-CT0220160200-066-F01CT0220Homo 3. 0 409112 BE243971 Hs. 50649 quinone oxidoreductase homolog 3. 0 414403 AW969551 Hs. 76064 ribosome protein L27a 3. 0 427418 AA402587 Hs. 325520 LAT1-3TM protein 3. 0 455481 AW948317 gb : RCO-MT0015-280300-021-a09 MT0015 Homo 3. 0 444396 T65213 Hs. 4257 ESTs 3. 0 407235 D20569 Hs. 169407 SAC2 (suppressor of ac6n mutations 2, y 3. 0 431431 AL096711 Hs. 252953 Human DNA sequence from clone RP3-403A15 3. 0 451391 AA017410 Hs. 40568 ESTs 3. 0 430251 AA609246 Hs. 181451 ESTs « 3. 0 420658 AW965215 Hs. 130707 ESTs 3. 0 442786 H50733 Hs. 256261 ESTs, Moderately similar to ALU8 HUMAN A 3. 0 440897 AW104275 Hs. 148348 ESTs 3. 0 444609 AW571659 Hs. 278081 ESTs 3. 0 433062 AK001757 Hs. 281348 hypotheficalprotein FLJ10895 3. 0 408523 AW833259 Hs. 314287 ESTs 3. 0 443477 R32325 Hs. 221794 ESTs 3. 0 423869 BE409301 Hs. 134012 C1q-relatedfactor 3. 0 405488 ENSP00000220888' : ZINC FINGER TRANSCRIPTI 3. 0 414988 C17535 gb : C17535HumanplæenlacDNA (TFujiwara 3. 0 440471 AA886146 Hs. 307944 ESTs 3. 0 416355 H49875 Hs. 268906 ESTs 3. 0 408926 AF217525 Hs. 49002 Down syndrome cell adhesion molecule 3. 0 424028 AF055084 Hs. 153692 Homo sapiens cDNA FW 14354 hs, done Y7 2. 9 438201 AA780243 Hs. 54647 ESTs 2. 9 413851 AW897510 Hs. 137387 ESTs 2. 9 402229 BE262804 mitochondrial ribosomal protein S2 2. 9 444145 BE153823 Hs. 282385 ESTs, Weakly similar to 2004399A chromos 2. 9 423770 AW976766 Hs. 132776 Homo sapiens cDNA FLJ 10077 hs, clone HE 2. 9 439627 BE621702 Hs. 29076 hypothetical protein FU21841 2. 9 414232 W86946 Hs. 238246 hypothetical protein FLJ22479 2. 9 400533 ENSP00000209376' : PRED65 protein (Fragmen 2. 9 440483 A1200836 Hs. 150386 ESTs 2. 9 443502 A1074528 Hs. 133949 ESTs 2. 9 449667 AB023227 Hs. 23860 KIAA1010 protein 2. 9 446809 AW590171 Hs. 101413 ESTs 2. 9 408788 AL134947 Hs. 213956 Homo sapiens BAC clone RP11-10205 from Y 2. 9 413627 BE182082 Hs. 246973 ESTs 2. 9 449655 A1021987 Hs. 59970 ESTs 2. 9 407378 AA299264 Hs. 57776 ESTs. Moderately similar to 138022 hypot 2. 9 400090 Eos Control 2. 9 454968 AW849046 gb : lL3 CT0214 150300-08SH06 CT0214 Homo 2. 9 423352 AA324808 Hs. 193576 ESTs 2. 9 426197 AA004410 Hs. 100009 acyl-Coenzyme A oxidase 1, palmitoyl 2. 9 452102 U04343 Hs. 27954 CD86 antigen (CD28 antigen ligand 2, B7-2. 9 415346 Z43108 gb : HSC13E071 normalized infant brain cDN 2. 9 436726 AA324975 Hs. 198689 ESTs, Weakly similar to T00079 hypotheti 2. 9 442513 AF150207 Hs. 207949 ESTs 2. 9 425012 T77666 Hs. 92414 Homo sapiens cDNA : FLJ22030 fis, clone H 2. 9 402322 Target Exon 2. 9 427235 A1126288 Hs. 192232 ESTs 2. 9 456412 AW749617 Hs. 280776 tankyrase, TRF1-inleræ6ng ankynn-ela 2. 9 431196 AW974436 Hs. 154929 ESTs 2. 9 439379 AA835002 Hs. 125611 ESTs 2. 9 423757 AL049337 Hs. 132571 Homo sapiens mRNA cDNADKFZp564P016 (fr 2. 9 446134 AW161234 Hs. 13993-TBP-like 1 2. 9 435645 A1052789 Hs. 133263 ESTs 2. 9 449385 A1650471 Hs. 347290 ESTs 2. 9 444161 N52543 Hs. 142940 ESTs 2. 9 406635 U07162 gb : Human clone LNA11 auloan6body 19 hea 2. 9 419239 AA468183 Hs. 184598 HomosapienscDNA : FLJ23241 fis, clone C 2. 9 458760 A1498631 Hs. 111334 fenilin, lightpolypep6de 2. 9 427245 AA421022 Hs. 97739 ESTs 2. 9 400658 ENSP00000237081-: KtM1217 PROTEIN (FRAGM 2. 9 430701 A1760833 Hs. 293971 ESTs 2. 9 435294 T84084 Hs. 196008 Homo sapiens cDNA FLJ11723 fis, clone HE 2. 9 429927 NM001115 Hs. 2522 adenylate cyclase 8 (brain) 2. 9 446160 AW392197 Hs. 218003 ESTs 2. 9 420674 NM000055 Hs. 1327 butyrylcholinesterase 2. 9 424330 AW073953 Hs. 333396 Homo sapiens DNA 3596 fis, clone PL 2. 9 418915 A1474778 Hs. 118977 ESTs 2. 9 425922 AL157466 Hs. 162751 Homo sapiens mRNA ; cDNA DKFZp761E2423 (f 2. 9 447512 AW958148 Hs. 129454 ESTs 2. 9 449990 A1279010 Hs. 48821 ESTs 2. 8 423779 AW071837 Hs. 57971 ESTs 2. 8 427395 AW298741 Hs. 97861 ESTs, Moderately similar to 138022 hypot 2. 8 416188 BE157260 Hs. 79070 v-myc avian myelocytomatosis viral oncog 2. 8 426746 J03626 Hs. 2057 uridine monophosphate synthelase (orolat 2. 8 400362 AF068294 Hs. 272414 Homo sapiens HDCM845P mRNA, partial cds 2. 8

457579 AB030816 Hs. 36761 HRAS-tike suppressor 2. 8 451059 AW297465 Hs. 267150 KIAA1409 protein 2. 8 403903 C5001632' : git10645308k) b ! AAG21430. 1 ! ACOO 2. 8 444491 A1151091 Hs. 270714 ESTs 2. 8 455899 BE155112 gb : PM1-HT0350-151299-003-a03HT0350Homo 2. 8 457292 Api921270 Hs. 281462 hypothetical protein FLJ14251 2. 8 428305 AA446628 Hs. 2799 cartilage linking protein 1 2. 8 435375 A1733610 Hs. 187832 ESTs 2. 8 409078 AW327515 Hs. 346209 ESTs 2. 8 436109 AA922153 Hs. 132760 hypothetical protein MGC15729 2. 8 444656 A1277924 Hs. 145199 ESTs 2. 8 426384 A1472078 Hs. 303662 hypothetical protein FU13189 (FU13189) 2. 8 424200 AA337221 gb : EST41944 Endometria'tumor Homo sapie 2. 8 438243 Al581311 ESTs 2. 8 434012 AA621425 Hs. 186256 ESTs 2. 8 402711 Target Exon 2. 8 442955 Al683534 Hs. 131583 ESTs 2. 8 418319 AW611703 Hs. 190173 ESTs, Weakly similar to A46010 X-linked 2. 8 438934 BE220137 Hs. 124323 ESTs 2. 8 438689 AW129261 Hs. 181672 ESTs 2. 8 420083 AA478847 Hs. 42484 hypothetical protein FLJ10618 2. 8 400315 U46120 Hs. 193392 Human expressed unknown mRNA 2. 8 433563 A1732637 Hs. 277901 ESTs 2. 8 458093 Api207788 Hs. 343628 sialyltransferase 4B (beta-ga'actosidase 2. 8 409157 AA064631 gb : zf72c03. s1 Soaresinealgland_N3HPG 2. 8 450597 A1701635 Hs. 207077 ESTs 2. 8 425300 AW601773 Hs. 270259 ESTs 2. 8 458617 Z25900 Hs. 18724 Homo sapiens mRNA ; cDNA DKFZp564F093 (fr 2. 8 418312 AW972468 Hs. 170307 Ral guanine nucleotide exchange factor R 2. 8 430335 D80007 Hs. 239499 KIAA0185 protein 2. 8 454581 AW809189 gb : MR4-ST0118-261099-012-e10ST0118Homo 2. 8 419735 AW750056 Hs. 169577 Homo sapiens cDNA FW14743 hs, clone NT 2. 8 436265 AA731331 Hs. 190668 ESTs 2. 8 439481 AF086294 Hs. 125844 ESTs 2. 8 441964 AA972619 Hs. 20506 ESTs. Weakly similar to 138022 hypolheti 2. 8 422648 D86983 Hs. 118893 Melanoma associated gene 2. 8 430503 AA533574 Hs. 152274 ESTs 2. 8 403942 Target Exon 2. 8 420565 A1806770 Hs. 30258 ESTs 2. 8 439069 H63144 Hs. 184178 ESTs, WeaklysimilartoALUB_HUMAN ! ! ! ! 2. 8 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel 2. 8 408137 A1694131 Hs. 29002 KIAA1706 protein 2. 8 451692 AL137422 Hs. 26849 HomosapiensmRNA ; cDNADKFZp761A1623 (f 2. 8 419713 AW968058 Hs. 92381 nudix (nucleoside diphosphate linked rtroi 2. 8 452526 W38537 Hs. 280740 hypothetical protein MGC3040 2. 8 414300 A1304870 Hs. 188680 ESTs 2. 8 419741 NM 007019 Hs. 93002 ubiquitin carrier protein E2-C 2. 8 437933 Api276132 Hs. 146155 ESTs 2. 7 405941 Target Exon 2. 7 443210 A1692649 Hs. 9451 hypothetical protein MGC13168 2. 7 450651 W79000 Hs. 44545 ESTs, Weakly similar to B34087 hypotheti 2. 7 426765 AA743603 Hs. 172108 nucleoporin 88kD 2. 7 418886 AA993982 Hs. 130858 ESTs 2. 7 429483 AA974832 Hs. 128708 ESTs 2. 7 430426 AA478807 Hs. 125173 ESTs 2. 7 439019 AF085902 Hs. 271737 ESTs 2. 7 400924 Target Exon 2. 7 458070 AW503578 Hs. 209406 ESTs. Weakly similar to 138600 zinc ting 2. 7 427299 AA830210 Hs. 214263 ESTs, ModeratelysimilartoALU1_HUMANA 2. 7 442621 Al004333 Hs. 130553 ESTs, Weakly similar to AWA_HUMAN ! ! ! ! 2. 7 437643 AL080280 gb : Homo sapiens mRNA full length insert 2. 7 426925 NM001196 Hs. 315689 Homo sapiens cDNA : FLJ22373 fis, clone H 2. 7 443392 A1055821 Hs. 293420 ESTs 2. 7 429972 A1700846 Hs. 234518 ribosomal protein L23 2. 7 438875 AA827640 Hs. 189059 ESTs 2. 7 422551 AW967284 gb : EST379359 MAGE resequences, MAGJ Homo 2. 7 446139 H77395 Hs. 39749 ESTs 2. 7 429115 AA446728 Hs. 289020 Homo sapiens cDNA FW 14098 hs, clone MA 2. 7 428612 AA770001 Hs. 188778 ESTs 2. 7 439947 AB006627 Hs. 6788 astrotacfin 2. 7 439699 AF086534 Hs. 187561 ESTs, ModeratelysimilartoALU1_HUMANA 2. 7 438335 Api498421 Hs. 243168 ESTs 2. 7 456680 AL137758 Hs. 116072 Homo sapiens mRNA ; cDNA DKFZp434H245 (fr 2. 7 412074 S74683 Hs. 73139 ADP-ribosyltransferase 1 2. 7 412225 AW902042 gb : QVO-NN1022-170400-193-c02NN1022Homo 2. 7 438801 AA825971 Hs. 124284 ESTs 2. 7 442892 A1038379 Hs. 131865 ESTs 2. 7 432964 AF118395 Hs. 279865 trans-prenyltransferase 2. 7 403790 NM001334' : Homo sapiens cathepsin O (CTS 2. 7 400335 Y13187 Hs. 248068 Homo sapiens dmd gene, intron 11 2. 7 415467 R60891 Hs. 260274 ESTs 2. 7 428715 AW293716 Hs. 53126 ESTs 2. 7 457750 A1651474 Hs. 163944 ESTs 2. 7

424480 AA341442 Hs. 205299 ESTs 2. 7 444822 BE164351 Hs. 292767 hypothetical protein FLJ23109 2. 7 432651 AW973744 Hs. 293100 ESTs 2. 7 439823 AW665287 Hs. 124514 ESTs 2. 7 457021 AW968934 Hs. 173108 HomosapienscDNA : FLJ21897 fis, clone H 2. 7 440026 AA861299 Hs. 160371 ESTs 2. 7 446960 AW294936 Hs. 156762 ESTs 2. 7 435046 AA662772 Hs. 174330 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 7 431999 AL133573 Hs. 272312 Homo sapiens mRNA ; cDNADKFZp434J2235 (f 2. 7 458527 A1950256 Hs. 224875 ESTs 2. 7 445899 A1263736 Hs. 145626 ESTs 2. 7 404254 ENSP00000082468* : DJ45P21. 3 (butyrophilin 2. 7 402344 Target Exon 2. 7 426503 AA380153 gb : EST93093 Skin tumor I Homo sapiens cD 2. 7 446420 AW015693 Hs. 135614 ESTs 2. 7 426914 AA393328 Hs. 194303 ESTs 2. 7 407903 A1287341 Hs. 154029 bHLH factor Hes4 2. 7 433009 AA761668 gb : nz2kO8. s1 NCI_CGAP_GCB1 Homosapiens 2. 7 403431 TargetExon 2. 7 403290 C10001011-: gij47582121reflNP_004411. 1ld 2. 7 435143 R12375 Hs. 194600 ESTs 2. 7 416569 H64891 gb : yr68h03. r1 Soares fetal liver spleen 2. 7 428690 A1948490 Hs. 98765 ESTs 2. 7 425128 BE561929 Hs. 154718 tumor protein D52-like 2 2. 7 443361 A1792628 Hs. 133273 ESTs 2. 7 404053 Target Exon 2. 7 435113 AA665469 Hs. 117136 ESTs 2. 6 405717 CX000838 : gillOO926331reflNP-055314. 11 pu 2. 6 413098 BE065279 gb : RC1-BT0314-030500-016-bO9 BT0314 Homo 2. 6 444884 A1201094 Hs. 148540 ESTs 2. 6 419015 T79262 Hs. 14463 ESTs 2. 6 423234 AA323534 Hs. 296162 AD037 protein 2. 6 406871 AA993857 Hs. 180842 ribosome protein L13 2. 6 428670 AA431682 Hs. 134832 ESTs 2. 6 408371 AF161545 Hs. 44439 hypothetical protein 2. 6 413929 BE501689 Hs. 75617 coliagen, type IV, alpha 2 2. 6 408369 R38438 Hs. 182575 solute carrier family 15 (H ? ? ? transport 2. 6 419817 AA743434 Hs. 193778 ESTs 2. 6 415788 AW628686 Hs. 78851 KIAA0217 protein 2. 6 427388 BE379610 Hs. 177592 ribosomal protein, large, P1 2. 6 451018 AW965599 Hs. 247324 mitochondria nbosomal protein S14 2. 6 405863 Target Exon 2. 6 454037 AW998716 gb : PM4-BN0067-250300-002-f11 BN0067 Homo 2. 6 430147 R60704 Hs. 234434 hairy/enhancer-of-sptit related with YRP 2. 6 425480 AB023198 Hs. 158135 KIAA0981 protein 2. 6 407182 AA312551 Hs. 230157 ESTs 2. 6 439538 AA837323 Hs. 56407 ESTs 2. 6 449249 T52285 Hs. 193115 Homo sapiens mRNA for KIAA1764 protein, 2. 6 429569 AA454993 Hs. 138343 ESTs, Weakly similar to 178885 serineÅh 2. 6 402936 ENSP00000217246' : DJ803K15. 1 (novel prote 2. 6 420670 AW973577 ESTs 2. 6 455409 AW936832 gb : PM2-DT0023-050400-003-hO3 DT0023 Homo 2. 6 413151 H47969 Hs. 141971 ESTs, WeaklysimilartoALU1_HUMANALUS 2. 6 422484 AA568770 Hs. 123158 Homo sapiens CDNA FLJ 12830 fis, clone NT 2. 6 400780 NM007325' : Homo sapiens glutamate recept 2. 6 429258 AA448765 gb : zx10eO9. r1 Soares_total_fetus_Nb2HF8_ 2. 6 448970 AW138582 gb : UI-H-BI1-acw-a-06-0-Ul. s1 NCl_CGAP_Su 2. 6 402615 C1003844' : gi6912550tre<iNP036483. 1o) 2. 6 417099 BE537357 Hs. 306995 hypothetical protein MGC5457 2. 6 428397 AA428040 gb : zw50e02. r1 Soares_totatfetus_Nb2HF8_ 2. 6 449164 A1632772 Hs. 264165 ESTs 2. 6 412584 X54870 Hs. 74085 DNA segment on chromosome 12 (unique) 24 2. 6 443635 A1080230 Hs. 134214 ESTs 2. 6 402981 Target Exon 2. 6 433258 A1806626 Hs. 207300 ESTs, Weakly similar to ALUB_HUMAN ! ! ! ! 2. 6 428917 AA437337 Hs. 16689 ESTs 2. 6 418557 BE140602 Hs. 246645 ESTs 2. 6 445211 BE045601 Hs. 118248 ESTs, Weakly similar to YC1 8_HUMAN HYPOT 2. 6 404423 C8000067-: gil10432400lembjCAC10Z90. 1l (A 2. 6 435953 A1767087 Hs. 114142 ESTs 2. 6 435937 AA830893 Hs. 119769 ESTs 2. 6 439220 AW295340 Hs. 130417 ESTs, Weakly similar to 1195 HUMAN ZINC 2. 6 419597 W73692 gb : zd50cO1. s1 Soares_éta_heatNbHHl9W 2. 6 436852 A1814817 Hs. 269099 ESTs 2. 6 430569 AF241254 Hs. 178098 angiotensin I converting enzyme (peptidy 2. 6 443845 Al590084 Hs. 148485 ESTs, Weakly similar to A47161 Mac-2-bin 2. 6 414223 AA954566 Hs. 238246 hypothetical protein FU22479 2. 6 443770 AW815924 gb : MR3-ST021&191199-Ot2-a10 ST0218 Homo 2. 6 450443 AA009847 Hs. 120744 ESTs 2. 6 435523 T62849 Hs. 11090 membrane-spanning 4-domains, subfamily A 2. 6 400492 C10001573' vgi|73027491gb ; MF57827. 1l (AE 2. 6 450202 AW969756 Hs. 34145 ESTs, Weakly similar to B49647 GTP-bindi 2. 6 416845 H95279 Hs. 293788 gb : yu20h02. s1 Scares fetal liver spleen 2. 6

446423 AW139655 Hs. 150120 ESTs 2. 6 447587 AW292139 Hs. 115789 ESTs 2. 6 437014 AA808757 Hs. 222531 ESTs, Weakly similar to S59501 interfero 2. 6 426411 AK000708 Hs. 169764 hypothetical protein FU20701 2. 6 432668 AA558601 Hs. 43296 ESTs 2. 6 436682 Api590055 Hs. 124110 ESTs 2. 6 426894 A1204209 Hs. 143911 ESTs 2. 6 402605 Target Exon Z6 457554 AA570111 Hs. 155873 ESTs. Weakly similar to ALUE_HUMAN ! ! ! ! 2. 6 438166 N30158 Hs. 122645 ESTs 2. 6 443021 AA368546 Hs. 8904 Ig superfamily protein 2. 6 427005 AA394228 Hs. 97494 ESTs 2. 6 437085 AA743935 Hs. 202329 ESTs 2. 6 408603 R25283 Hs. 326416 Homo sapiens mRNA ; cDNA DKFZp564H1916 (f 2. 6 431019 NM5249 Hs. 2714 forehead box G18 2. 5 437287 AA748180 Hs. 159346 hypothetical protein FU21369 2. 5 458552 AW136139 Hs. 245656 ESTs 2. 5 436350 AA713661 Hs. 121091 ESTs 2. 5 421988 AW450481 Hs. 161333 ESTs 2. 5 416704 H77795 Hs. 39785 ESTs 2. 5 447830 R98920 Hs. 164314 ESTs 2. 5 413278 BE563085 Hs. 833 interferon-stimutated protein, 15 kDa 2. 5 406789 A1041403 ribosome protein L29 2. 5 433683 A1817723 Hs. 22678 hypothetical protein FU21832 2. 5 433523 H29882 ESTs 2. 5 452296 T65535 Hs. 111539 ESTs 2. 5 428878 AA436884 Hs. 48926 ESTs 2. 5 442476 AF069475 gb : AF069475 Homo sapiens astrocytoma lib 2. 5 452785 AL359942 Hs. 296434 erythroid differentiation and denudeati 2. 5 444422 A1768623 Hs. 108264 ESTs 2. 5 420579 AA278449 Hs. 137429 ESTs 2. 5 416505 H66470 Hs. 16004 ESTs 2. 5 402595 C1001578' : gil6759903lgblMF28099. 1l (AF1 2. 5 447930 R44574 Hs. 107510 ESTs 2. 5 459527 AW977556 Hs. 291735 ESTs, Weak ! ysimiiartol78885serineXth 2. 5 458421 A1279978 Hs. 22547 ESTs 2. 5 427527 A1809057 Hs. 293441 immunoglobulin heavy constant mu 2. 5 436035 AA703679 Hs. 106999 ESTs, Weakly similar to SYT5_HUMAN SYNAP 2. 5 453362 H14988 Hs. 107375 ESTs 2. 5 423600 A1633559 Hs. 310359 ESTs 2. 5 433325 AW206986 Hs. 143905 ESTs 2. 5 415983 A1436798 Hs. 117078 Homo sapiens cDNA : FLJ23028 fis, clone L 2. 5 431198 AL047634 Hs. 231913 ESTs 2. 5 430530 AA480870 Hs. 47660 ESTs 2. 5 455276 BE176479 gb : RC3-HT0585-160300-022-b09 HT0585 Homo 2. 5 416665 H72974 gb : yu28a10. s1 Soares fetal liver spleen 2. 5 422352 AA766296 Hs. 99200 ESTs 2. 5 427613 AW273851 Hs. 98025 ESTs 2. 5 453685 AL110309 gb : DKFZpS64L0278_r1564 (synonym : hfbr2) 2. 5 450508 R37408 Hs. 101654 ESTs 2. 5 436361 AA825814 Hs. 149065 ESTs 2. 5 427709 A1631811 Hs. 180403 STRIN protein 2. 5 432036 AF224266 Hs. 272373 interleukin 20 2. 5 422752 BE247253 Hs. 21263 suppressor of potassium transport defect 2. 5 413786 AW613780 Hs. 13500 ESTs 2. 5 439706 AW872527 Hs. 59761 ESTs, Weakly similar to DAP1 HUMAN DEATH 2. 5 451533 NM_004657 Hs. 26530 serum deprivation response (phosphatidyl 2. 5 414959 D59968 Hs. 45184 Homo sapiens cDNA FW12284 ñs, clone MA 2. 5 449919 Al674685 Hs. 200141 ESTs 2. 5 458891 A1659166 Hs. 207144 ESTs 2. 5 427140 AA398487 Hs. 97642 ESTs 2. 5 405239 U89281 oxidative 3 alpha hydroxysteroid dehydro 2. 5 428450 NM 014791 Hs. 184339 KIAA0175 gene product 2. 5 443753 AW367578 Hs. 134749 ESTs 2. 5 432888 T86823 gb : yd81aO8. s1 Soaresfetalliverspleen 2. 5 445065 A1806657 Hs. 302024 glycoprotein beta-Gal 3'-sulfotransferas 2. 5 431202 AA495824 Hs. 188822 ESTs, Weakly similar to A46010 X-linked 2. 5 445658 Api469062 Hs. 172660 ESTs 2. 5 435330 R16769 Hs. 173174 Homo sapiens CDNA FU 14429 fis, clone HE 2. 5 435703 AW630133 Hs. 83313 GK003 protein 2. 5 456232 AL040357 gb : DKFZp43400713_r1434 (synonym : htes3) 2. 5 421955 AK000160 Hs. 121576 Homo sapiens cDNA FW20153 hs, clone CO 2. 5 420796 L34355 Hs. 99931 sarcoglycan, alpha (5OkD dystrophin-asso 2. 5 425428 AL110261 Hs. 157211 DKFZP586B0621 protein 2. 5 437627 AW469925 Hs. 257837 ESTs 2. 5 408574 AA328046 Hs. 46405 polymerase (RNA) it (DNA directed) polyp 2. 5 418733 AA227714 Hs. 179703 KIAA0129 gene product 2. 5 440473 BE562314 Hs. 98711 Homo sapiens, clone IMAGE : 3677165, mRNA, 2. 5 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 2. 5 411480 AW848022 gb : IL3-CT0214-231299-053-A09 CT0214 Homo 2. 5 436391 AJ227892 Hs. 146274 ESTs 2. 5 424947 R77952 ESTs, Weakly similar to altematively sp 2. 5 450831 R37974 Hs. 25255 ESTs 2. 5

447527 Al702896 Hs. 42091 ESTs 2. 5 424686 AA345504 gb : EST51529GallbladderttHomosapiens 2. 5 453385 AW296101 Hs. 252806 ESTs 2. 5 TABLE 128 : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408292 1050507_1 AW178363 AW846011 AW645964 AW845988 AW845977 AW846002 409157 1103631 AA064631AA722000AA064793 409189 110687_t AAt 25984 AA127189 AA065075 AA070377 AA100017 AA079891 AA113255 AA075168 AA082764 AA083380 N84829 AA084752 AA076512 AA085119 AA085208 AA085045 411480 1247089_1 AW848022 AW848704 AW848168 AW848959 AW848476 AW848699 AW848700 AW848761 411537 1248899_1 BE073250 BE073378 BE073379 AW850533 AW850529 411543 1249127_1 AW851248 AW851425 AW850805 AW851021 AW850905 411565 1249756_1 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628 411671 125369 1 BE049094 AA700765 H86770 AA094646 R02483 C03868 N56170 411688 1254076_1 AW953440 T08189 AW857085 412021 1272156_1 AW885592 AW885594 AW885579 AW885651 412135 1279148_1 AW895309 AW895290AW895307 AW895397 AW895378 AW895402 AW895403AW895311 AW895298AW895390 AW895488AW895468 AW895481 AW895288 412225 1284108_1 AW902042 N77591 412811 132943 1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 AI424991 AI693507 AI863108 AA599060 A1091148 AA598689 R39887 AA813482 AW016452 H06383 R41807 Al364263M620528 Al241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734 413098 1349115 1 BE065279 BE065306 BE065164 BE065389 413986 140720 1 143567 H24159 AA134240 414988 1511316 1 C17535 D59244 D58878 D79090 415131 1523680 D61119 D81508D81734 415346 1534581 1 Z43108 F06295 R13085 416422 1593811 1 H60457 H68709 H73528 H54335 R87154 416569 1601567 1 H64891 R93444 R93458 R05590 416665 1607797_1 H72974 W28967 419597 1863413-1 W73692 W73836 W95650 420352 192979 1 BE258835 AW968316 AA258918 AW843305 R14744 A1580388 BE071923 R36280 420670 1954421 AW973577AA553621AA279187 422551 217767 1 AW967284M312192M312203 424009 234177 1 F11690AW965370M333586D30830 424200 236595 1 AA337221 AA336756 AW966196 424686 242486 1 AA345504 AA345251 AW963243 424947 245247_1 R77952 AA348809 AW959960 AW959962 A1565552 AW070702 AA973910 R85973 425146 247244 1 AW954627AW954629M351258R25935 425331 250199 1 AW962128AA355353 AA427363 426503 268283J AA380153AA380233AW963529 428397 2909941 AA428040AW889864AA836434 429258 301917 1 AA448765 C04967 C03045 AA658293 429940 310384_1 W25215M461079M461391 430183 314t22 BE010038 AA676833A) 311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 A) 936370AA552514 T67280 AA039909 430535 319643 1 AW968485 AW968670 AA480922 BE350425 432044 340773_1 AW972727 M524829 AW972733 432646 3519091 AW753310AW974000AA557840AA558570AW751539 432888 355780 1 T86823 A1821425 A1732232 AA569589 AA570737 433009 357371_1 M761668M573621R92814R09670 433523 368873_1 H29882 AW665533 AW149901 A1572917 AA598500 A1686466 A1336390 AW864390 AW864320 433835 374758 1 A1806185 AA610063 A1693089 A1693075 434589 38929_1 AF147363T47219T47218 436608 42361_3 M628980AI126603BE504035 437034 4317131 AA742643AA808575AW976668 437643 43998 1 AL080280 T73124 H02689 AL080281 438243 453072 Al ! 581311AA781682AA781678 438458 457837 1 AW975186M807807D29548 439533 47349_1 W76021 AF088052 W72465 442476 543547 1 AF069475 AF069477 AF069476 443770 579849 1 AW815924 AW815926 A1085174 444016 58899_1 M448154AV647571 448970 791254 1 AW138582 A1638298 A1631640 A1963868 A1611082 450166 8267771 AA429504 R41904 AA279467 H09648 AA007236 453685 977734_1 AL110309 AW083119 H22881 454037 996287_1 AW998716AW022148N68020 454177 1049351 1 AW807321 AW807262 AW 177104 AW807319 AW807115 AW807344 AW807324 AW178116 BE141575 AW845849 AW807105 AW845868 BE140942 AW807178 AW807167 AW807398 AW807320 AW807306 AW845866 454451 1206502 1 AW846706 AW846703 AW752167 AW846700 AW846699 AW752176 AW846694 454457 1207274_1 AW753456 AW753036 AW854868 AW854862 454581 1225710_1 AW809189 AW809219 AW813574 454765 1233905_1 AW819629AW654320 454860 1237732_1 AW835767AW835537BE160187 454968 12470291 AW849046 AW847956 AW849039 AW847957 AW848279 AW848698 AW849034 AW849033 455104 1253737_1 BE064863 BE153698 AW856751 BE153820 BE064737 BE153674 BE064730 BE065062 BE153536 AW856622 BE155079 BE064651 BE153665 BE064650 BE064691 455276 1272541 1 BE176479 BE176678 BE176357 BE176550 AW886079 BE176676 BE176615 BE176555 BE176489 BE176610 BE176362

455409 1288355_1 AW936832 AW936609 AW936657 AW936611 AW936739 AW936734 AW936779 AW936688 AW936659 AW936738 AW936827 AW936737 AW936736 AW936740 AW936833 AW936777 AW936830 AW936834 AW936829 AW936772 AW936638 AW936658 AW936636 AW936774 AW936778 AW936766 AW936776 AW936831 AW9 455481 1293182 1 AW948317 AW948322 AW948329 AW948316 AW948298 AW948330 AW948325 AW948324 455646 1348557 1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 455778 1364506 1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 455899 1381547-1 BE155112 BE155154 BE155087 BE155247 BE155499 BE155367 BE155452 456232 168294 1 AL040357 AA883621 AA203230 456304 176820 1 A1820973 A1734077 A1820984 AA225796 AA225060 AA225101 457364 328154_1 AW971037M508019M492345 TABLE 12C : Pkey : Unique Eos probeset identifier number Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'efers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_psifon 400492 9213749 Minus 123881-124090 400533 6981826 Minus 277132-277595 400645 8117693 Minus 58471-58716 400658 8118459 Minus 73525-73644 400780 8131663 Minus 118372-118619 400814 8569925 Minus 72840-72924, 74761-74849 400924 7107613 Minus 30309-30498 401272 9797373 Minus 98374-98509 401454 9186923 Minus 114659-114832 401702 1871197 Minus 68182-68325 402229 9965022 Minus 15739-15951, 16166-16779 402274 2935596 Plus 5604-6527 402322 7630359 Minus 75078-75203 402344 8099256 Minus 76812-79040 402595 7705171 Plus 37870-37923, 39664-39717, 71711-71764 402604 9909420 Plus 20393-20767 402605 9909420 Minus 47680-47973 402615 9926801 Plus 131390-132157 402711 8901247 Minus 114306-115418 402747 9212492 Minus 7105-7357 402855 9662953 Minus 59763-59909 402936 8894303 Plus 51655-51771 402981 9944246 Minus 45716-45889 403108 8980955 Plus 93253-93667 403212 7630897 Minus 156037-156210 403288 8081479 Plus 133763-133899, 135813-135958 403290 8083176 Plus 19288-20076 403291 7230870 Plus 95177-95435 403349 8569773 Minus 167815-168374 403431 7139839 Plus 56509-56860 403481 9965004 Plus 93496-93633 403696 3135242 Minus 143467-143634 403790 8084957 Minus 87826-87947, 89835-90002 403849 7708855 Plus 95043-96519 403903 7710671 Minus 101165-102597 403942 7711825 Minus 99606-99757 403961 7596976 Minus 110393-110603 404053 3548785 Plus 61797-64205 404120 7342152 Plus 135775-136000 404185 4572584 Minus 129171-129327 404254 9367203 Plus 129350-129873 404272 9885189 Plus 83207-83355, 84358-84496, 9051-90720, 91371-91447 404423 7407959 Plus 34438-34618 404584 9857511 Plus 138651-139153 404592 9943965 Minus 39067-39225 404632 9796668 Plus 45096-45229 405046 7596829 Minus 4373-4528 405183 7209940 Plus 12335-12653 405238 7249119 Minus 51728-51836 405239 7249119 Plus 144345144464, 144690-144836, 151750-151883. 152407-152484 405348 2914717 Minus 43310-43462 405488 7131455 Minus 75771-75883, 105295105398, 134754-134875 405558 1621110 Plus 4502-4644, 5983-6083 405717 9588573 Plus 11275-11973 405760 6066938 Minus 37424-38045 405863 7657810 Plus 49410-49620 405941 6758796 Plus 2798-3444 406395 9256242 Minus 20805-20960 406478 9857502 Plus 68314-68523, 6885368950 406481 9864741 Minus 91439-91579 TABLE 13A : 964 GENES UP-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES Table 13A lists about 678 genes up-regulated in lower grade glioblastoma (LGG) compared to normal normal adult tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average LGG to'average'normal tissues was greater than or equal to 3. 0. The'average'LGG level was set to the 85t

percentage amongst various LGG tumors. The'average'normal 6ssue level was set to the 85m percen6le amongst various non-malignant adult tissues. In order to remove gene- specific background levels of non-specific hybridization, the 10° percentile value amongst the various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene fiole R1 : Ratio of LOWER GRADE GLIOBLASTOMA to NORMAL ADULT TISSUES Pkey ExAccn UnigenelD Unigene Title R1 427343 AI880044 Hs. 176977 protein kinase C binding protein 2 67. 6 409389 AB007979 Hs. 301281 HomosapiensmRNA, chromosome1speciEc 58. 2 418375 NM_003081 Hs. 84389 synaptosomal-associated protein, 25kD 53. 8 431917 D16181 Hs. 2868 peripheral myelin protein 2 50. 6 428321 Al699994 Hs. 2868 peripheral myelin protein 2 48. 3 426325 D28114 Hs. 169309 myelin-associated oligodendrocyte basic 44. 3 435147 AL133731 Hs. 4774 Homo sapiens mRNA ; cDNA DKFZp761 C1712 (f 44. 2 456759 BE259150 Hs. 127792 delta (Drosophila)-ike3 43. 8 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 40. 8 429007 D80642 gb : HUM092E09BHumanfetalbrain (TFujiwa 40. 1 417183 R52089 Hs. 172717 ESTs 38. 8 430838 N46664 Hs. 169395 hypothetica) protein FLJ12015 36. 8 413472 BE242870 Hs. 75379 solutecarierfamily1 (gliaihigha'h 34. 9 425088 AA663372 Hs. 169395 hypotheUcal protein FU12015 34. 4 429276 AF056085 Hs. 198612 G protein-coupled receptor 51 34. 2 424140 Z48051 Hs. 141308 myelin oligodendrocyte glycoprotein 33. 9 450133 AW969769 Hs. 105201 ESTs 33. 8 423849 AL157425 Hs. 133315 Homo sapiens mRNA ; cDNA DKFZp761J1324 (f 32. 8 413333 M74028 Hs. 75297 hbnoblastgrowthfactor1 (acidic) 32. 8 449494 AW237014 Hs. 315369 Homo sapiens cDNA : FLJ23075 fis, clone L 31. 3 402604 Target Exon 30. 3 412733 AA984472 Hs. 74554 KIAA0080 protein 28. 8 416829 AB013805 Hs. 80220 catenin (cadherin-associated protein), d 28. 2 439239 A1031540 Hs. 235331 ESTs 27. 9 444378 R41339 Hs. 47860 neurotrophic tyrosine kinase, receptor, 27. 1 439415 F05538 Hs. 4273 ESTs 26. 2 425048 H05468 Hs. 164502 ESTs 25. 5 429903 AL134197 Hs. 93597 cyclin-dependent kinase 5, regulatory su 25. 3 425057 AA826434 Hs. 1619 achaete-scute complex (Drosophila) homol 24. 0 425799 T08133 Hs. 182906 Homo sapiens mRNA for K1AA1872 protein, 23. 5 447359 NM_012093 Hs. 18268 adenylate kinase 5 23. 5 425842 A1587490 Hs. 159623 NK-2 (Drosophila) homolog B 23. 2 423853 A8011537 Hs. 133466 slit (Drosophila) homolog 1 23. 2 435708 A1362949 Hs. 75169 ESTs 22. 9 437268 At754847 Hs. 227571 regulator of G-protein signaliing 4 21. 6 409395 U46745 Hs. 336678 dystrobrevin, alpha 21. 1 441285 NM_002374 Hs. 167 microtubule-associated protein 2 20. 4 422656 Ai870435 Hs. 1569 LIM homeobox protein 2 20. 0 425523 AB007948 Hs. 158244 KIAA0479 protein 19. 7 437204 AL110216 Hs. 22826 ESTs, Weakly similar to 155214 salivary 19. 5 416370 N90470 Hs. 203697 ESTs, Weakly similar to 138022 hypotheti 19. 4 441497 R51064 Hs. 23172 ESTs 19. 3 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 19. 1 408604 D51408 Hs. 21925 ESTs 18. 9 413597 AW302885 Hs. 117183 ESTs 18. 8 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (CIEBP), 18. 8 428392 H10233 Hs. 2265 secretory granule, neuroendocrine protei 18. 6 429466 M85835 Hs. 12827 ESTs 18. 2 448302 A1480208 Hs. 182906 Homo sapiens mRNA for KIAA1872 protein, 18. 2 439199 R40373 Hs. 26299 ESTs 17. 4 448743 AB032962 Hs. 21896 KIAA1136 protein 17. 4 418338 NM 002522 Hs. 84154 neuronalpentraxinl 17. 3 444513 AL120214 Hs. 7117 glutamate receptor, ionotropic, AMPA 1 17. 2 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 17. 1 447004 AW296968 Hs. 157539 ESTs 16. 8 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 16. 5 448672 A1955511 Hs. 225106 ESTs 16. 1 452372 At885742 Hs. 228474 ESTs 15. 8 424120 T80579 Hs. 290270 ESTs 15. 7 424581 M62062 Hs. 150917 catenin (cadherin-associated protein), a 15. 6 424790 AL119344 Hs. 13326 ESTs, Weakly similar to 2004399A chromos 15. 4 426269 H15302 Hs. 168950 Homo sapiens mRNA ; cDNA DKFZp566A1046 (f 15. 2 446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 15. 2 453642 A1370936 Hs. 34074 dipepfidylpepfidase ! 14. 9 429037 X81895 Hs. 194765 H. sapiens GENX-5624 mRNA, 3'UTR 14. 7 441440 A1807981 Hs. 30495 ESTs 14. 6 429927 NM001115 Hs. 2522 adenylate cyclase 8 (brain) 14. 6 415849 R20529 Hs. 6806 ESTs 14. 4 418110 R43523 Hs. 217754 hypothetical protein FU22202 14. 2 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 14. 0 409638 AW450420 Hs. 21335 ESTs 14. 0 441350 AB020690 Hs. 7782 paraneoptastic antigen MA2 13. 9 415734 NM_014747 Hs. 78748 KIAA0237 gene product 13. 7

424945 A1221919 hypothetical protein FLJ10582 13. 6 426344 H41821 Hs. 322469 transcriptional activator of the c-fos p 13. 4 446372 AB020644 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 13. 3 429946 R49390 Hs. 254129 KIAA1678 13. 3 444119 R41231 Hs. 184261 ESTs, Weakly similar to T26686 hypotheG 13. 3 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 13. 2 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 13. 2 412266 N59006 Hs. 26133 ESTs 13. 2 436878 BE465204 Hs. 47448 ESTs 13. 1 428536 Al143139 Hs. 2288 visinin-like 1 13. 1 425649 U30930 Hs. 158540 UDPglycosyitransferase8 (UDP-galactose 13. 1 428982 NM 005097 Hs. 194704 leucine-rich, glioma inacUvated 1 13. 0 437948 AA772920 Hs. 303527 ESTs 13. 0 444124 R43097 Hs. 6818 ESTs 12. 9 428342 AI739168 Homo sapiens cDNA FW 13458 hs, ctone PL 12. 7 419249 X14767 Hs. 89768 gamma-aminobutyncacid (GABA) Arecepto 12. 7 412959 D87458 Hs. 75090 KIAA0282 protein 12. 6 419863 AW952691 Hs. 93485 HomosapiensmRNA ; cDNADKFZp761D191 (fr 12. 6 431467 N71831 Hs. 256398 Homo sapiens mRNA ; cDNADKFZp434E0528 (f 12. 6 431019 NM005249 Hs. 2714 forehead box G1B 12. 4 420547 AF155140 Hs. 98738 gonadotropin-regu) testcular RNA he 12. 4 430091 AB032958 Hs. 233023 KIAA1132 protein 12. 4 448595 AB014544 Hs. 21572 KIAA0644 gene product 12. 2 447342 A1199268 Hs. 19322 Homo sapiens, Similar to RIKEN cDNA 2010 12. 2 409049 A1423132 Hs. 146343 ESTs 12. 0 421264 AL039123 Hs. 103042 microtubule-associated protein 1B 11. 9 451952 AL120173 Hs. 301663 ESTs 11. 9 411305 BE241596 Hs. 69547 myelinbasicprotein 11. 8 433551 A1985544 Hs. 12450 protocadherin 9 11. 6 431988 AC002302 Hs. 77202 protein kinase C, beta 1 11. 6 415170 R44386 Hs. 164578 ESTs 11. 5 408562 Ait6323 Hs. 31141 Homo sapiens mRNA for KIAA1568 protein, 11. 4 435501 AW051819 Hs. 129908 KIAA0591 protein 11. 4 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 11. 1 423419 R55336 Hs. 23539 ESTs 11. 1 424432 AB037821 Hs. 146858 protocadherin 10 10. 9 433896 AW294729 Hs. 274461 ESTs 10. 9 415293 R49462 Hs. 106541 ESTs 10. 9 447101 N72185 Hs. 44189 ESTs 10. 9 440105 AA694010 Hs. 6932 Homosapiensclone23809mRNAsequence 10. 9 438054 AA776626 Hs. 169309 ESTs 10. 8 433597 AA708205 Hs. 100343 ESTs 10. 7 421659 NM 014459 Hs. 106511 protocadherin 17 10. 6 445102 AW204610 Hs. 22270 ESTs 10. 6 425154 NM 001851 Hs. 154850 coliagen, type IX, alpha 1 10. 6 451625 R56793 Hs. 106576 alanine-glyoxylate aminotransferase 2-li 10. 6 435191 R15912 Hs. 4817 Homosapiensclone24461mRNAsequence 10. 6 450154 R15891 Hs. 281587 Human (cloneCTG-A4) mRNAsequence 10. 5 407886 AW969688 Hs. 100826 ESTs 10. 4 420345 AW295230 Hs. 25231 ESTs 10. 4 428728 NM016625 Hs. 191381 hypothetical protein 10. 3 424997 AL138167 Hs. 96920 ESTs 10. 3 440184 AB002297 Hs. 7022 dedicator of cyto-kinesis 3 10. 2 419078 M93119 Hs. 89584 insulinoma-associated 1 10. 2 445495 BE622641 Hs. 38489 ESTs, Weakly similar to 138022 hypotheU 10. 1 416857 AA188775 Hs. 292453 ESTs 10. 0 445041 T64183 Hs. 282982 solute carder 10. 0 419271 N34901 Hs. 238532 ESTs 9. 8 446711 AF169692 Hs. 12450 protocadherin9 9. 8 426847 S78723 Hs. 298623 Shydroxytryptamine (serotonin) receptor 9. 7 427304 AA761526 Hs. 163853 ESTs 9. 7 418097 R45137 Hs. 21868 ESTs 9. 7 449300 Api656959 Hs. 346514 ESTs 9. 7 419985 H66373 Hs. 5856 ESTs, Highly similar to bA393J16. 3 [H. sa 9. 7 443785 AW449952 Hs. 190125 basic-helix-loop-helix-PAS protein 9. 5 415486 H12214 Hs. 13284 ESTs, Weakly similar to 2109260A B cell 9. 5 453220 AB033089 Hs. 32452 Homo sapiens mRNA for KIAA1263 protein, 9. 5 438209 AL120659 Hs. 61 i I aryl-hydrocarbon receptor nuclear transl 9. 4 424028 AF055084 Hs. 153692 Homo sapiens cDNA FW 14354 hs, clone Y7 9. 4 419683 AA248897 Hs. 48784 ESTs 9. 4 414175 A1308876 Hs. 103849 hypotheticalprotein DKFZp761D112 9. 2 400292 AA250737 Hs. 72472 BMP-R1B 9. 2 408947 AL080093 Hs. 49117 Homo sapiens mRNA ; cDNA DKFZp564N1662 (f 9. 2 454048 H05626 Hs. 6921 ESTs 9. 2 454027 R40192 Hs. 21527 Human DNA sequence from clone GS1-1 15M3 9. 1 441016 AW138653 Hs. 25845 ESTs 9. 0 425187 AW014486 Hs. 22509 ESTs 9. 0 445568 H00918 Hs. 268744 MAA1796 protein 8. 9 453941 U39817 Hs. 36820 Bloom syndrome 8. 9 422411 AW749443 Hs. 22511 ESTs 8. 8 447350 A1375572 Hs. 172634 ESTs 8. 8 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 8. 7 448902 Z45998 Hs. 22543 HomosapiensmRNA ; cDNADKFzp761l1912 (f 8. 7

448986 H42169 Hs. 347310 hypothetical protein FW14627 8. 6 423135 N67655 Hs. 26411 ESTs 8. 5 418030 BE207573 Hs. 83321 neunomedin B 8. 4 448769 N66037 Hs. 38173 ESTs 8. 4 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Circadian Oscillat 8. 3 400293 N51002 Hs. 306480 HomosapiensmRNA ; cDNADKFZp761E2112 (f 8. 3 415279 F04237 Hs. 1447 glial hbnilary acidic protein 8. 2 451516 Af800515 Hs. 12024 ESTs 8. 2 419629 AB020695 Hs. 91662 KIAA0888 protein 8. 2 437034 AA742643 gb : ny9lcO1. s1 NCI_CGAP_GCB1 Homosapiens 8. 2 456965 AW131888 Hs. 172792 ESTs, Weakly similar to hypothetical pro 8. 1 417417 F05745 Hs. 89512 ATPase, Ca transporting, plasma membrane 8. 1 452279 M286844 Hs. 61260 hypothetical protein FW13164 8. 1 422864 AA318323 Hs. 12827 gb : EST20390RetinallHomosapienscDNA 8. 1 452526 W38537 Hs. 280740 hypothetical protein MGC3040 8. 0 435793 AB037734 Hs. 4993 Kit1313 protein 7. 9 415669 NM 005025 Hs. 78589 serine (orcysteine) proteinase inhibito 7. 9 407168 R45175 Hs. 117183 ESTs 7. 9 447414 D82343 Hs. 74376 neuroblastoma (nerve tissue) protein 7. 8 442710 A1015631 Hs. 23210 ESTs 7. 8 416836 D54745 Hs. 80247 cholecystokinin 7. 8 419721 NM 001650 Hs. 288650 aquaponn 4 7. 7 438080 Art77381 Hs. 291530 ESTs, Weakly similar to AWCHUMAN ! ! ! ! 7. 7 436109 AA922153 Hs. 132760 hypothetical protein MGC15729 7. 7 428845 AL157579 Hs. 153610 KIAA0751 gene product 7. 7 448321 NM 005883 Hs. 20912 adenomatous polyposis coli like 7. 7 410305 AF030409 Hs. 62185 solutecarierfamily9 (sodium/hydnDgen 7. 6 443392 A1055821 Hs. 293420 ESTs 7. 6 429038 AL023513 Hs. 194766 seizueelatedgene6 (mouse)-like 7. 5 418738 AW388633 Hs. 6682 solute carrier family 7, (cationic amino 7. 5 423361 AW170055 Hs. 47628 ESTs 7. 5 447198 D61523 Hs. 283435 ESTs 7. 5 448555 A1536697 Hs. 159863 ESTs 7. 5 458332 A1000341 Hs. 220491 ESTs 7. 4 407034 U84540 gb : Human dystrobrevin isoform DTN-3 (DTN 7. 4 425354 U62027 Hs. 155935 complement component 3a receptor 1 7. 4 426814 AF036943 Hs. 172619 myelin transcrip60n factor 1-like 7. 4 448507 AL133109 Hs. 21333 Homo sapiens mRNA ; cDNADKFZp566N1047 (f 7. 4 439845 AL355743 Hs. 56663 Homo sapiens EST from clone 41214, full 7. 4 449078 AK001256 Hs. 22975 KIAA1576 protein 7. 3 410102 AW248508 Hs. 279727 ESTs ; homologueofPEM-3lCionasavignyi 7. 2 425741 AF052152 Hs. 159412 Homosapiensclone24628mRNAsequence 7. 2 440210 AW674562 Hs. 125296 ESTs 7. 2 415651 A1207162 Hs. 3815 stathmin-like-protein RB3 7. 2 428409 AW117207 Hs. 98523 ESTs 7. 1 413409 A1638418 Hs. 1440 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 7. 1 443992 AW022228 Hs. 322922 ESTs 7. 1 455601 A1368680 Hs. 816 SRY (sex determining region Y)-box 2 7. 1 427540 R12014 Hs. 20976 ESTs 7. 0 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 7. 0 424893 AW295112 Hs. 153648 Homo sapiens CDNA FU 13303 fis, clone OV 7. 0 452355 N54926 Hs. 29202 G protein-coupled receptor 34 7. 0 414696 AF002020 Hs. 76918 Niemann-Pickdisease, typeC1 7. 0 440152 AB002376 Hs. 7006 KIAA0378 protein 7. 0 454293 H49739 Hs. 134013 ESTs, Moderately similar to HK61-HUMAN H 7. 0 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 7. 0 416805 F13271 Hs. 79981 Human clone 23560 mRNA sequence 7. 0 419991 AJ000098 Hs. 94210 eyes absent (Drosophila) homolog 1 7. 0 424343 AW956360 Hs. 4748 adenylate cyclase activating polypeptide 6. 9 408369 R38438 Hs. 182575 soiute carrier famity 15 (H ? ? ? transport 6. 9 449605 AW138581 Hs. 198416 ESTs 6. 9 444396 T65213 Hs. 4257 ESTs 6. 9 444165 AL137443 Hs. 10441 hypothetical proteinFLJ11236 6. 9 414245 BE148072 Hs. 75850 WAS protein family, member 1 6. 9 412155 R38167 Hs. 12449 Homo sapiens transmembrane protein HTMPt 6. 9 424624 AB032947 Hs. 151301 Ca2+dependent activator protein for secr 6. 9 448681 AL109781 Hs. 21754 HomosapiensmRNAfulilengthinsertcDN 6. 9 411379 Al816344 Hs. 12554 ESTs, Weakly similar to NPL4HUMANNUCLE 6. 9 446782 A1653048 Hs. 144006 ESTs 6. 8 426919 AL041228 ELAV (embryonic lethal, abnormal vision, 6. 8 423346 A1267677 Hs. 127416 synaptoianin 1 6. 8 436643 AA757626 Hs. 10941 ESTs, Weakly similar to IPP1_HUMAN PROTE 6. 8 414922 D00723 Hs. 77631 glycine cleavage system protein H (amino 6. 8 410037 AB020725 Hs. 58009 KIAA0918 protein 6. 8 442613 At004002 Hs. 130522 Kv channel-interacting protein 1 6. 8 413589 AW452631 Hs. 313803 ESTs, HighlysimilartoAF1578331noncl 6. 8 422175 N79885 Hs. 6382 ESTs, Highly similar to T00391 hypotheti 6. 8 421141 AW117261 Hs. 125914 ESTs 6. 7 452786 R61362 Hs. 106642 ESTs, Weakly similar to T09052 hyptheti 6. 7 441916 AA993571 Hs. 129075 ESTs 6. 7 448533 AL119710 Hs. 21365 nucleosome assembly protein 1-like 3 6. 7 428037 N47474 Hs. 89230 potassium intermediate/smatl conductance 6. 7 423343 AA324643 Hs. 246106 ESTs 6. 7

456723 Z43902 Hs. 4748 adenylate cyclase activating polypeptide 6. 7 414214 D49958 Hs. 75819 glycoprotein M6A 6. 7 434811 AW971205 Hs. 114280 ESTs 6. 7 424922 BE386547 Hs. 217112 hypothetical protein MGC10825 6. 7 449328 A1962493 Hs. 345303 ESTs 6. 6 431553 X78075 Hs. 2799 cartilage linking protein 1 6. 6 420156 AW449258 Hs. 6187 ESTs 6. 6 431117 AF003522 Hs. 250500 delta (Drosophila)-like 1 6. 6 422960 AW890487 Hs. 63984 cadherin 13, Hcadherin (heart) 6. 6 429239 AA448419 Hs. 45209 ESTs 6. 5 453924 R49295 Hs. 24886 ESTs 6. 5 433929 A1375499 Hs. 27379 ESTs 6. 5 426529 AF090100 Hs. 170241 Homo sapiens clone IMAGE 23915 6. 5 414683 S78296 Hs. 76888 hypothetical protein MGC12702 6. 4 409746 NM_004794 Hs. 56294 RAB33A, member RAS oncogene family 6. 4 419169 AW851980 Hs. 262346 ESTs, Weakly similar to S72482 hypothe6 6. 4 453590 AF150278 Hs. 33578 KIAA0820 protein 6. 4 422263 AA307639 Hs. 129908 KIAA0591 protein 6. 4 421688 AK000307 Hs. 106825 hypothetical protein FLJ20300 6. 4 447197 R36075 gb : yh88bO1. s1 Scares placenta Nb2HP Homo 6. 3 425588 F07396 Hs. 46627 ESTs 6. 3 410366 A1267589 Hs. 302689 hypothetical protein 6. 3 419498 AL036591 Hs. 20887 hypothetical protein FW10392 6. 3 446997 AA383439 Hs. 16758 Spir-1 protein 6. 3 427958 AA418000 Hs. 98280 potassium intermediatelsmall conductance 6. 3 445908 R13580 Hs. 13436 Homo sapiens clone 24425 mRNA sequence 6. 3 412068 S72043 Hs. 73133 metallothionein 3 (growth inhibitory fac 6. 3 452834 A1638627 Hs. 105685 KA1688 protein 6. 3 408790 AW580227 Hs. 47860 neurotrophic tyrosine kinase, receptor, 6. 3 418512 AW498974 diacylglycerol kinase, zeta (104kD) 6. 2 410099 AA081630 KIAA0036 gene product 6. 2 452744 At267652 Hs. 246107 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 6. 2 427897 NM_017413 Hs. 303084 apelin ; peptide ligand for APJ receptor 6. 2 416427 BE244050 Hs. 79307 Rac/Cdc42 guanine exchange factor (GEF) 6. 2 439274 AF086092 Hs. 48372 ESTs 6. 2 431552 Al815863 Hs. 259873 axonal transport of synaptic vesicles 6. 2 439607 BE540565 Hs. 159460 ESTs 6. 2 408950 AA707814 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 6. 2 412709 AL022327 Hs. 74518 KIAA0027 protein 6. 2 435624 AF218942 Hs. 24889 formic 2 6. 1 425977 R15138 Hs. 165570 Homo sapiens clone 25052 mRNA sequence 6. 1 420077 AW512260 Hs. 87767 ESTs 6. 1 457005 AJ007421 Hs. 172597 sal (Drosophila)-like 3 6. 1 440471 AA886146 Hs. 307944 ESTs 6. 1 423770 AW976766 Hs. 132776 Homo sapiens cDNA FLJ10077 fis, clone HE 6. 1 438624 AA889055 Hs. 123468 ESTs 6. 1 452752 AW044058 Hs. 33578 KIAA0820 protein 6. 1 438208 AL041224 Hs. 65379 ESTs 6. 1 416072 AL110370 Hs. 79000 growth associated protein 43 6. 1 407808 AA663559 Hs. 279789 histone deacetylase 3 6. 1 433701 AW445023 Hs. 15155 ESTs 6. 1 419704 AA429104 Hs. 45057 ESTs 6. 1 429250 H56585 Hs. 198308 tryptophan rich basic protein 6. 1 433244 A8040943 Hs. 271285 KIAA1510 protein 6. 0 422544 AB018259 Hs. 118140 KIAA0716 gene product 6. 0 420133 AA426117 Hs. 155543 ESTs 6. 0 440491 R35252 Hs. 130558 ESTs. Weakly similar to 2109260A B cell 6. 0 422728 AW937826 Hs. 103262 ESTs, Weakly similar to ZN91 HUMAN ZINC 6. 0 415257 F03016 Hs. 27513 ESTs 5. 9 417160 N76497 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 5. 9 430188 AL049242 Hs. 234794 Homo sapiens mRNA ; cDNA DKFZpS64B083 (fr 5. 9 437372 AA323968 Hs. 283631 hypothetical protein DKFZp547G183 5. 9 430471 AF064845 Hs. 241523 hypothetical protein FU10142 5. 9 433523 H29882 ESTs 5. 9 408926 AF217525 Hs. 49002 Down syndrome cell adhesion molecule 5. 9 427317 AB028955 Hs. 175780 KiM1032 protein 5. 9 426140 AF131798 Hs. 343768 Homosapiensclone25119mRNAsequence 5. 9 409892 AW956113 Hs. 7149 gb : EST368183 MAGE resequences, MAGD Homo 5. 8 459516 A1049662 Hs. 246858 EST 5. 8 442910 Al365130 Hs. 11307 ESTs, Weakly similar to T19326 hypthe6 5. 8 414737 A1160386 Hs. 125087 ESTs 5. 8 424332 AA338919 Hs. 101615 ESTs 5. 8 403142 NM002706' : Homo sapiens protein phosphat 5. 8 420111 AA255652 gb : zs21h11. r1 NCI_CGAP_GCB1 Homosapiens 5. 8 450813 A1739625 Hs. 203376 ESTs 5. 8 402145 Target Exon 5. 8 434792 AA649253 Hs. 132458 ESTs 5. 8 422421 AA325138 Hs. 235873 hypothetical protein FU22672 5. 8 445745 AB007924 Hs. 13245 KIAA0455 gene product 5. 8 420608 BE548277 Hs. 103104 ESTs 5. 8 451407 AA131376 Hs. 343809 fibroblast growth factor 128 5. 7 441102 AA973905 intermediate filament protein syncoilin 5. 7 424560 AA158727 Hs. 150555 protein predicted by clone 23733 5. 7

430287 AW182459 Hs. 125759 ESTs, Weakly similar to LEUS_HUMAN LEUKE 5. 7 405238 Target Exon 5. 7 432890 NM014442 Hs. 279751 sialic acid binding Ig-like lec6n 8 5. 7 440492 R39127 Hs. 21433 hypothetical protein DKFZp547J036 5. 7 413492 D87470 Hs. 75400 KIAA0280 protein 5. 7 427624 AA406245 Hs. 24895 ESTs 5. 7 418079 R40058'Hs. 6911 ESTs 5. 6 424458 M29273 Hs. 1780 myelin associated glycoprotein 5. 6 448299 AA497044 Hs. 20887 hypotheticalprotein FU10392 5. 6 429698 Api685086 Hs. 26339 ESTs, Weakly similar to S21348 probable 5. 6 430228 AW950939 Hs. 6382 ESTs, Highly similar to T00391 hypotheti 5. 6 445255 NM-014841 Hs-12477 synaptosomal-associated protein, 91 kDa 5. 6 436887 AW953157 Hs. 193235 hypothetical protein DKFZp547D155 5. 6 452898 AA814497 Hs. 78792 ESTs 5. 6 435538 AB011540 Hs. 4930 low density lipoprotein receptor-related 5. 6 436035 AA703679 Hs. 106999 ESTs, WeakqsimilartoSYT5 HUMANSYNAP 5. 5 412190 R16180 Hs. 274461 ESTs 5. 5 459278 AW294659 Hs. 34054 HomosapienscDNA FW22488hs, clone H 5. 5 416490 AF090116 Hs. 79348 regutator of -protein signaliing 7 5. 5 423449 A1497900 Hs. 33067 ESTs 5. 5 440866 A1703103 Hs. 271360 hypothetical protein MGC16275 5. 5 432154 A1701523 Hs. 112577 ESTs 5. 4 423476 AL035633 Human DNA sequence from clone RP5-1046G1 5. 4 428588 F12101 Hs. 185701 HomosapiensmRNAfulilengthinsertcDN 5. 4 447773 AI423930 Hs. 36790 ESTs, Weakly similar to putative p150 [H 5. 4 436936 AL134451 Hs. 197478 ESTs 5. 4 427250 R35941 Hs. 25418 ESTs 5. 4 427302 AA400540 Hs. 135282 HomosapienscDNAFW11554hs, cloneHE 5. 4 452856 AF034799 Hs. 30881 protein tyrosine phosphatase, receptor t 5. 4 428795 R45503 Hs. 97469 ESTs, Highly similar to A39769 N-acetyll 5. 4 407385 AA610150 Hs. 272072 ESTs. Weakly similar to 138022 hypotheti 5. 4 405348 C7001664 : gil12698061ldbjlBAB21849. 1 (AB 5. 4 438330 AW450572 Hs. 257316 ESTs 5. 3 426503 AA380153 gb : EST93093 Skin tumor I Homo sapiens cD 5. 3 448148 NM 016578 Hs. 20509 HBV pX associated protein-8 5. 3 410386 W26187 Hs. 3327 Homo sapiens cDNA : FLJ22219 fis, clone H 5. 3 445225 AI216555 Hs. 202398 ESTs 5. 3 428784 Y12851 Hs. 193470 purinergic receptor P2X, ligand-gated io 5. 3 418759 AA227879 Hs. 187621 ESTs 5. 3 402605 Target Exon 5. 3 412046 Y07847 Hs. 73088 RAS-related on chromsome 22 5. 3 423869 BE409301 Hs. 134012 Ctq-relatedfactor 5. 2 430130 AL137311 Hs. 234074 Homo sapiens mRNA ; cDNA DKFZp761G02121 (5. 2 453096 AW294631 Hs. 11325 ESTs 5. 2 450475 AW805634 Hs. 205015 ESTs 5. 2 429139 F09092 Hs. 66087 ESTs 5. 2 451783 R42554 Hs. 210862 T-box, brain, 1 5. 2 436568 H12049 Hs. 91564 ESTs 5. 2 424330 AW073953 Hs. 333396 Homo sapiens cDNA FLJ 13596 fis, clone PL 5. 2 408453 AI369838 Hs. 45127 chondroitin sulfate proteoglycan 5 (neur 5. 2 447499 AW262580 Hs. 147674 protocadherin beta 16 5. 2 402855 NM001839' : Homo sapiens calponin 3, acid 5. 2 420805 L10333 Hs. 99947 reticulon 1 5. 2 426457 AW894667 Hs. 169965 chimerin (chimaerin) 1 5. 2 417355 D13168 Hs. 82002 endothelin receptor type B 5. 1 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxyla6ng ; 5. 1 450639 A1703186 Hs. 277174 ESTs 5. 1 412811 H06382 ESTs 5. 1 400379 NM018432 Homo sapiens ovarian cancer related prot 5. 1 441869 NM 003947 Hs. 8004 huntingtin-associated protein interactin 5. 1 442832 AW206560 Hs. 253569 ESTs 5. 1 422709 AA315331 Hs. 153485 ESTs 5. 1 411555 AF113537 Hs. 70669 HMP19 protein 5. 1 419043 T19167 Hs. 89566 ets variant gene 1 5. 0 430979 A1479755 Hs. 129010 ESTs 50 451320 AW118072 diacylglycerol kinase, zeta (104kD) 5. 0 423678 AW963357 Hs. 7847 ESTs 5. 0 429918 AW873986 Hs. 119383 ESTs 5. 0 452785 AL359942 Hs. 296434 erythroid differentiation and denucleati 5. 0 453128 AW026516 Hs. 31791 acylphosphatase 2, muscle type 5. 0 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 5. 0 430183 BE010038 gb : PM3-BN0176-100400-001-g04BN0176Homo 5. 0 449969 AW295142 Hs. 180187 Homo sapiens cDNA FW14337 hs, clone PL 5. 0 439108 AW163034 Hs. 6467 synaptogynn 3 5 0 426271 AF026547 Hs. 169047 chondroiEn sutfate proteoglycan 3 (neur 5. 0 451752 AB032997 Hs. 26966 KIAA1171 protein 5. 0 420578 AA813546 Hs. 99034 GTP-binding protein Rho7 4. 9 427315 AA179949 Hs. 175563 Homo sapiens mRNA ; cDNA DKFZp564N0763 (f 4. 9 428186 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 4. 9 445133 AW157646 Hs. 198689 ESTs 4. 9 410359 R38624 Hs. 106313 ESTs 4 9 427144 X95097 Hs. 2126 vasoactive intestinal peptide receptor 2 4. 9 448548 R13209 Hs. 21413 solutecarierfamily12, (potassium-chl 4. 9

457561 AA331517 Hs. 286055 chimerin (chimaerin) 2 4. 9 409100 H98216 Hs. 42245 ESTs, Moderately similar to 138022 hypot 4. 9 437117 AL049256 Hs. 122593 ESTs 4. 9 415101 R45531 Hs. 144534 ESTs 4. 9 438458 AW975186 gb : EST387294 MAGE resequences, MAGN Homo 4. 9 442026 A1243749 Hs. 8074 brain-specific angiogenesis inhibitor 3 4. 9 438283 A1458931 Hs. 37282 ESTs 4. 9 449714 AB033015 Hs. 23941 KIAAL 189 protein 4. 9 420871 AA702972 Hs. 65300 ESTs 4. 9 425256 BE297611 Hs. 155392 coiiapsin response mediator protein 1 4. 9 424001 W67883 Hs. 137476 paternally expressed 10 4. 9 419103 Z40229 Hs. 96423 hypothetical protein FU23033 4. 8 446727 AB011095 Hs. 16032 KlM0523protein 4. 8 408670 AF160967 Hs. 46784 potassium large conductance calcium-ac6 4. 8 428189 AA424030 Hs. 46627 ESTs 4. 8 420092 AA814043 Hs. 88045 ESTs 4. 8 410631 AA086469 Hs. 47171 ESTs 4. 8 449277 AA001064 Hs. 43670 ESTs 4. 8 436282 R91913 Hs. 272104 ESTs, Moderately similar to ALU1 HUMAN A 4. 8 414706 AW340125 Hs. 76989 KIAA0097 gene product 4. 8 438703 A1803373 Hs. 31599 ESTs 4. 8 439340 AB032436 Hs. 6535 brain-specific Na-dependent inorganic ph 4. 8 445890 AF055019 Hs. 21906 Homosapiensclone24670mRNAsequence 4. 7 436734 A1937612 Hs. 273758 hypothetical protein FU23112 4. 7 408177 A1241733 Hs. 43871 ESTs 4 7 445740 T78281 Hs. 13226 Homo sapiens cfone 2518 t MRNA sequence 4. 7 459527 AW977556 Hs. 291735 ESTs, Weakly similar to 178885 sednetth 4. 7 445523 Z30118 Hs. 293788 ESTs, Moderately similar to unnamed prot 4. 7 409172 Z99399 Hs. 122593 ESTs 4. 7 437748 AF234882 Hs. 5814 suppression of tumorigenicity 7 4. 7 421637 AF035290 Hs. 106300 Homosapiensclone23556mRNAsequence 4. 7 448044 Al458682 gb : tk13e01. x1NCLCGAPLu24 Homo sapiens 4. 7 459311 R40192 Hs. 21527 Human DNA sequence from clone GS1-115M3 4. 7 447891 R41754 Hs. 6496 ESTs 4. 7 426968 U07616 Hs. 173034 amphiphysin (Stiff-Mannsyndromewithbr 4. 7 404819 NM002688* : Homo sapiens peanut (Drosophi 4. 7 409125 R17268 Hs. 343567 axonal transport of synaptic vesicles 4, 7 437762 T78028 Hs. 154679 synaptotagmin I 4. 7 441668 A1611973 Hs. 136313 ESTs 4. 7 444190 A1878918 Hs. 10526 cysteine and glycine-rich protein 2 4. 6 429269 AA449013 Hs. 99203 ESTs 4. 6 433009 AA761668 gb : nz24cO8. s1 NCI_CGAP_GCB1 Homosapiens 4. 6 416586 D44643 Hs. 14144 secreted modular calcium-binding protein 4. 6 427701 AA411101 Hs. 243886 nuclear autoantigenic sperm protein (his 4. 6 426925 NM 001196 Hs. 315689 Homo sapiens cDNA : FLJ22373 fis, clone H 4. 6 410264 AK001853 Hs. 61508 Homo sapiens cDNA FLJ 10991 fis, clone PL 4. 6 437698 R61837 Hs. 7990 ESTs, Moderately similar to 184505 calci 4. 6 445813 Z42023 Hs. 106576 alanine-glyoxylate aminotransferase 2-li 4. 6 424264 D80400 Hs. 239388 Human DNA sequence from clone RP1-304B14 4. 6 448765 R15337 Hs. 21958 Homo sapiens mRNA ; cDNA DKFZp547D086 (fr 4. 6 419723 AL120193 Hs. 339810 longevity assurance (LAG1, S. cerevisiae 4. 6 424282 R76421 Hs. 135694 ESTs 4. 6 429401 AW296102 Hs. 99272 ESTs, Weakly similar to 532567 A4 protei 4. 6 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 4. 5 407896 D76435 Hs. 41154 Zic family member 1 (odd-paired Drosophi 4. 5 413248 T64858 Hs. 21433 hypothetical protein DKFZp547J036 4. 5 443731 At083928 Hs. 145418 ESTs 4. 5 449539 W80363 Hs. 58446 ESTs 4. 5 420362 U79734 Hs. 97206 hun&ngtin interacting protein 1 4. 5 443301 Api733614 Hs. 220587 ESTs, ModeratelysimitartoALU5_HUMANA 4. 5 423178 A1033140 Hs. 124983 Homo sapiens mRNA ; cDNA DKFZp564C142 (fr 4. 5 437933 A1276132 Hs. 146155 ESTs 4. 5 446544 Api631932 Hs. 7047 ESTs. Weakly similar to Unknown [H. sapie 4. 5 411642 NM014932 Hs. 71132 neuroligin 1 4. 5 428282 N34905 Hs. 44653 Homo sapiens cDNA : FLJ22669 fis, clone H 4. 5 411498 NM_014210 Hs. 70499 ecotropic viral integration site 2A 4. 5 408622 AA056060 Hs. 202577 Homo sapiens cDNA FLJ12166 fis, clone MA 4. 5 436637 A1783629 Hs. 26766 ESTs 4. 5 438456 AA913381 Hs. 20594 ESTs 4. 5 400533 ENSP00000209376' : PRED65 protein (Fragmen 4. 4 413951 AW051200 Hs. 75640 natriureticpeptideprecursorA 4. 4 417632 R20855 Hs. 5422 glycoprotein M68 4. 4 425138 H08849 Hs. 167464 glutamate receptor, ionoUOpic, N-methyl 4. 4 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 4. 4 413812 AW188687 Hs. 44748 ESTs 4. 4 448451 AW015994 Hs. 345433 gb : UI-H-BIOpabh+094Ul. s1 NCI_CGAP_S 4. 4 432281 AK001239 Hs. 274263 hypothetical protein FU10377 4. 4 458760 Api498631 Hs. 111334 ferri6n, light polypeptide 4. 4 405819 NM002578 : Homo sapiens p21 (CDKN1A)-æ6 4. 4 447877 A1435184 Hs. 164252 ESTs 4. 4 431342 AW971018 Hs. 21659 ESTs 4. 4 408577 H50572 Hs. 19515 ESTs, Highly similar to NRG3-HUMAN PRO-N 4. 4 445729 H21066 Hs. 13223 Homo sapiens mRNA hutl length insert cDN 4. 4

422253 W81526 Hs. 118329 ESTs, ModeratelysimilartoGAD_HUMANGA 4. 4 419088 A1538323 Hs. 52620 integrin, beta 8 4. 4 428305 AA446628 Hs. 2799 cartilage linking protein 1 4. 4 410768 AF038185 Hs. 66187 Homosapiensclone23700mRNAsequence 4. 4 428722 U76456 Hs. 190787 tissue inhibitor of metatloproteinase 4 4. 4 451621 A1879148 Hs. 26770 fatty acid binding protein 7, brain 4. 4 424240 AB023185 Hs. 143535 calcium/calrtodulin-dependent protein kin 4. 3 433932 AW954599 Hs. 169330 neuronal protein 4. 3 439935 S75105 Hs. 8358 glutamate receptor, ionotropic. kainate 4. 3 436039 AW023323 Hs. 121070 ESTs 4. 3 416220 N49776 Hs. 170994 hypothetical protein MGC10946 4. 3 409953 AA332277 Hs. 57691 cadherin 18, type 2 4. 3 456497 AW967956 Hs. 123648 ESTs, Weakly similar to AF108460 1 ubinu 4. 3 420352 BE258835 gb : 601117374F1 NIH MGC 16 Homo sapiens c 4. 3 454032 W31790 Hs. 194293 ESTs, Weakly similar to 154374 gene NF2 4. 3 421790 AW896201 Hs. 22654 sodium channel, voltage-gated, type 1, a 4. 3 444218 AF070641 Hs. 10684 Homosapiensclone24421mRNAsequence 4. 3 436391 AJ227892 Hs. 146274 ESTs 4. 3 452106 A1141031 Hs. 21342 ESTs 4. 3 422465 AF073710 Hs. 117149 regulator of G-protein signalling 9 4. 3 439285 AL133916 hypothetical protein FW20093 4. 3 404541 Nom030795 : Homo sapiens stathmin-iike 4 (4. 3 424572 M19650 2', 3'-cyclic nucleo6de 3'phosphodieste 4. 3 449048 Z45051 Hs. 22920 similar to S68401 (cattle) glucose induc 4. 3 409182 AA064970 Hs. 122593 ESTs 4. 3 444600 R41398 Hs. 6996 ESTs 4. 3 408838 A1669535 Hs. 40369 ESTs 4. 3 410592 R94088 Hs. 43569 ESTs 4. 3 440168 AA868507 Hs. 126141 ESTs 4. 2 445078 A1869975 Hs. 4775 junctophilin 3 4. 2 428670 AA431682 Hs. 134832 ESTs 4. 2 411666 AF106564 Hs. 71346 neurohlament3 (150kDmedium) 4. 2 412505 AA974491 Hs. 21734 ESTs 4. 2 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 4. 2 441707 R42637 Hs. 21963 hypothetical protein DKFZp76180514 4. 2 449433 A1672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 4. 2 441523 AW514263 Hs. 301771 ESTs. Weakly similar to ALUF_HUMAN ! ! ! ! 4. 2 448243 AW369771 Hs. 52620 integrin, beta 8 4. 2 429149 AW193360 Hs. 197962 ESTs, Weak) ysimi ! arto 138022 hypotheti 4. 2 430676 AF084866 gb : Homo sapiens envelope protein RIZ3 (4. 2 404584 Target Exon 4. 2 422798 R92347 Hs. 34574 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 2 451254 A1571016 Hs. 172967 ESTs 4. 2 428585 AB007863 Hs. 185140 KIAA0403 protein 4. 2 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 4. 2 425287 R88249 Hs. 155524 peanut (Drosophila)-like 2 4. 2 425790 AW136286 Hs. 288446 ESTs 4. 2 450407 NM 000810 Hs. 24969 gamma-aminobutyric acid (GABA) A recepto 4. 2 425241 AA324624 Hs. 155247 aldolase C, fructose-bisphosphate 4. 2 445292 AV653264 Hs. 13982 Homo sapiens cDNA FLJ14666 fis, clone NT 4. 1 400777 NM 007325' : Homo sapiens glutamate recept 4. 1 422170 A1791949 Hs. 112432 anG-Mullerian hormone 4. 1 410765 A1694972 Hs. 66180 nucleosome assembly protein 1-like 2 4. 1 425402 A1215881 Hs. 24970 ESTs, Weakly similar to B34323 GTP-bindi 4. 1 438461 AW075485 Hs. 286049 phosphoserine aminotransferase 4. 1 421268 A1126821 Hs. 30514 ESTs 4. 1 416439 AA180363 Hs. 118769 ESTs 4. 1 419687 At638859 Hs. 227699 ESTs, WeahlysimilartoT2D3_HUMANTRANS 4. 1 435040 A1932350 Hs. 152825 ESTs 4. 1 439774 AL360257 Hs. 213493 Homo sapiens mRNA full length insert cDN 4. 1 458435 AI418718 Hs. 144121 ESTs, Weakly similar to T46916 hypotheti 4. 1 410320 AA084071 Hs. 93816 Homo sapiens mRNA ; cDNA DKFZp547N093 (fr 4. 1 436899 AA764852 Hs. 291567 ESTs 4. 1 454171 AW854832 gb : QV2-CT0261-201099-011-f05CT0261Homo 4. 1 453118 AW195849 Hs. 252757 ESTs 4. 1 428771 AB028992 Hs. 193143 KIAA1069 protein 4. 1 444185 AW298350 Hs. 66020 ESTs 4. 1 422374 AW732869 Hs. 1519 protein kinase, cAMP-dependent, regulato 4. 1 430147 R60704 Hs. 234434 hairy/enhancer-of-splitelatedwithYRP 4. 1 456060 C14904 Hs. 45184 Homo sapiens CDNA FU 12284 fis, clone MA 4. 1 433819 AW511097 Hs. 112765 ESTs 4. 1 415827 H17462 Hs. 23079 ESTs 4. 1 437397 AA349847 Hs. 4221 hypothetical protein DKFZp761H039 4. 1 441390 A1692560 Hs. 131175 ESTs 4. 1 440483 A1200836 Hs. 150386 ESTs 4. 0 435294 T84084 Hs. 196008 Homo sapiens cDNA FLJ 11723 fis, clone HE 4. 0 447397 BE247676 Hs. 18442 E-1 enzyme 4. 0 425390 A1092634 Hs. 156114 protein lyrosine phosphatase, non-recept 4. 0 432022 AL162042 Hs. 272348 Homo sapiens mRNA ; cDNADKFZp761L1212 (f 4. 0 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 4. 0 408081 AW451597 Hs. 167409 ESTs 4. 0 453313 BE005771 Hs. 153746 hypotheticalprotein FLJ22490 4. 0 436511 AA721252 Hs. 291502 ESTs 4. 0

448944 AB014605 Hs. 22599 atrophin-1 interacting protein 1 ; activi 4. 0 419412 AW161058 Hs. 90297 synudein, beta 4. 0 409091 AW970386 Hs. 269423 ESTs 4. 0 453438 A1469935 Hs. 22792 ESTs 4. 0 450582 A1339732 G-rich RNA sequence binding factor 1 4. 0 440553 AA889416 Hs. 344043 Homo sapiens cDNA FW14459 hs, clone HE 4. 0 437449 AL390153 Hs. 208339 HomosapiensmRNA ; cDNADKFZp762G113 (fr 4. 0 445888 AF070564 Hs. 13415 Homosapienscbne24571 mRNAsequence 4. 0 439450 R51613 Hs. 125304 ESTs 4. 0 453792 AL134539 Hs. 254129 KIAA1678 4. 0 459080 AW192083 Hs. 290855 ESTs 4. 0 438810 AW897846 Hs. 6421 hypothetical protein DKFZp761 N09121 4. 0 446233 Api282028 Hs. 25205 ESTs 4. 0 412754 AW160375 Hs. 74565 amyloid beta (A4) precursor-like protein 4. 0 412326 R07566 Hs. 73817 smali inducible cytokine A3 (homologous 4. 0 434859 BE255080 Hs. 299315 collapsin response mediator protein-5 ; C 4. 0 423279 AW959861 Hs. 290943 ESTs 4. 0 416340 N31772 Hs. 79226 fasciculation and elongation protein zet 3. 9 410126 BE169274 KIAA0036 gene product 3. 9 431173 AW971198 Hs. 294068 ESTs 3. 9 446936 H10207 Hs. 47314 ESTs 3. 9 424899 AL119387 Hs. 119062 ESTs 3. 9 419038 AW134924 Hs. 190325 ESTs 3. 9 450530 NM006668 Hs. 25121 cytochrome P450, subfamily 46 (cholester 3. 9 438142 T90309 Hs. 269651 ESTs 3. 9 412659 AW753865 Hs. 74376 olfactomedin related ER localized protei 3. 9 412788 AA120960 Hs. 198416 ESTs 3. 9 410909 AW898161 Hs. 53112 ESTs, ModeratelysimilartoALU8_HUMANA 3. 9 429433 AA452899 Hs. 213586 ESTs, Weakly similar to KIAA7353 protein 3. 9 432809 AA565509 Hs. 131703 ESTs 3. 9 424186 A1536021 Hs. 288706 HomosapienscDNAFW10281 hs, cloneHE 3. 9 425480 AB023198 Hs. 158135 KIAA0981 protein 3. 9 449932 A1675444 Hs. 263024 ESTs 3. 9 434072 H70854 Hs. 283059 Homo sapiens PR01082 mRNA, complete cds 3. 9 450590 A1701507 Hs. 273740 ESTs 3. 9 419586 A1088485 Hs. 144759 ESTs, Weakly similar to 138022 hypothefi 3. 9 414040 N58513 Hs. 32171 ESTs 3. 9 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel 3. 9 443210 A1692649 Hs. 9451 hypothetical protein MGC13168 3. 9 448448 NM 014954 Hs. 21239 KIAA0985 protein 3. 9 447067 R42098 Hs. 21964 ESTs 3. 9 413199 M62843 Hs. 75236 ELAV (embryonic lethal, abnormal vision, 3. 9 429421 AL031658 HumanDNAsequencefromcloneRP1-310013 3. 9 415796 R87548 Hs. 78854 ATPase, Na ? transporting, beta 2 polypep 3. 8 417333 AL157545 Hs. 173179 bromodomain and PHD finger containing, 3 3. 8 418771 AA807881 Hs. 25329 ESTs 3. 8 417565 A1203405 Hs. 47831 ESTs 3. 8 412420 AL035668 Hs. 73853 bone morphogene6c protein 2 3. 8 450202 AW969756 Hs. 34145 ESTs, Weakly similar to 849647 GTP-bindi 3. 8 435312 AJ243396 Hs. 4865 voltage-gated sodium channel beta-3 subu 3. 8 435832 AA425688 Hs. 41641 Bruno (Drosophila)-like 4, RNA binding 3. 8 435854 AJ278120 Hs. 4996 putative ankyrin-repeat containing prote 3. 8 459079 A1821122 gb : ns91g10. y5NCl_CGAP Pr3Homosapiens 3. 8 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring hnge 3. 8 421977 W94197 Hs. 110165 nbosomalproteinL26homoiog 3. 8 437756 AA767537 Hs. 197096 ESTs 3. 8 403696 C4001100-: gil5852342lgblMD54015. 1l (AFO 3. 8 453033 AA325869 Hs. 31463 KIAA0281 gene product 3. 8 441732 AW298818 Hs. 127341 ESTs 3. 8 415884 H22966 Hs. 13471 ESTs 3. 8 432646 AW753310 gb : RC3-CT0254-031099-012-cO5 CT0254 Homo 3. 8 451059 AW297465 Hs. 267150 KIAA1409 protein 3. 8 447057 Api423407 Hs. 157697 ESTs 3. 8 418915 A1474778 Hs. 118977 ESTs 3. 8 441111 A1806867 Hs. 126594 ESTs 3. 8 447818 W79940 Hs. 21906 Homosapiensclone24670mRNAsequence 3. 8 457183 H91882 Hs. 118569 Dvl-binding protein IDAX (inhibition of 3. 8 418358 L02840 Hs. 84244 potassium voltage-gated channel, Shab-re 3. 8 410711 AB002316 Hs. 65746 KIAA0318 protein 3. 8 428878 AA436884 Hs. 48926 ESTs 3. 8 438944 AA302517 Hs. 92732 KIAA1444 protein 3. 8 420898 AB002379 Hs. 100113 KIAA0381 protein 3. 8 418329 AW247430 Hs. 84152 cystathionine-beta-synthase 3. 8 427209 H06509 Hs. 92423 KIAA1566 protein 3. 7 445319 AF052108 Hs. 12513 Homo sapiens clone 23687 mRNA sequence 3. 7 428841 A1418430 Hs. 104935 ESTs 3. 7 414821 M63835 Hs. 77424 Fc fragment of IgG. high affinity la, re 3. 7 443310 BE552018 Hs. 133152 ESTs 3. 7 407728 AW071502 Hs. 175931 ESTs 3. 7 429643 AA455889 Hs. 167279 FYVE-fingercontaining RabS effector pro 3. 7 444127 N63620 Hs. 13281 ESTs 3. 7 425652 AB021742 Hs. 322431 neurogenic differentiation 2 3. 7 458072 A1890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 3. 7

459660 M79082 ESTs 3. 7 432188 AI362952 Hs. 2928 solute carrier family 7 (cationic amino 3. 7 437627 AW469925 Hs. 257837 ESTs 3. 7 408508 A1806109 Hs. 135736 KIAA1580 protein 3. 7 448999 AF179274 Hs. 22791 transmembrane protein with EGF-like and 3. 7 410623 AW958932 Hs. 293833 ESTs 3. 7 430744 AA485229 Hs. 105649 ESTs 3. 7 454392 BE260893 Hs. 236131 homeodomain-interacGng protein kinase 2 3. 7 453739 AL120266 ESTs 3. 7 407198 H91679 gb : yv04a07. s1 Soares fetal liver spleen 3. 7 405239 U89281 oxidative 3 alpha hydroxysteroid dehydro 3. 7 433615 AA732982 Hs. 269607 ESTs, Weakly similar to ALU 1 _HUMAN ALU S 3. 7 424800 AL035588 Hs. 153203 MyoD family inhibitor 3. 7 451027 AW519204 Hs. 40808 ESTs 3. 7 415131 D61119 gb : HUM158C11BC) ontechhumanfetaibrain 3. 7 443454 A1057494 Hs. 133421 ESTs 3. 7 423779 AW071837 Hs. 57971 ESTs 3. 7 452092 BE245374 Hs. 27842 hypotheticalprotein FLJ11210 3. 7 435910 A1084152 Hs. 21782 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 6 447028 A1973128 Hs. 167257 brain link protein-1 3. 6 452997 N64777 Hs. 44656 ESTs 3. 6 408601 U47928 Hs. 86122 protein A 3. 6 407332 Api801565 Hs. 200113 Homo sapiens cDNA FW 11379 fis, clone HE 3. 6 455646 BE064420 gb : RC4-BT0311-241199-012-cO8BT0311 Homo 3. 6 433657 Api244368 Hs. 8124 PH domain containing protein in retina 1 3. 6 421679 A1475110 Hs. 203933 ESTs 3. 6 448985 AA324885 Hs. 22777 carbonic anhydrase Xl 3. 6 414709 AA704703 Hs. 77031 Sp2 transcription factor 3. 6 411775 H08342 gb : yl87bO9. r1Soaresinfantbrån1NIBH 3. 6 439099 AB037800 Hs. 6462 protein kinase C and casein kinase subst 3. 6 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 3. 6 423611 AB011163 Hs. 129908 KIAA0591 protein 3. 6 453169 AB037815 Hs. 32156 KIAA1394 protein 3. 6 436954 AA740151 Hs. 130425 ESTs 3. 6 439249 AF086060 Hs. 170053 G-protein coupled receptor 88 3. 6 432058 AW665996 Hs. 130729 ESTs, WeaklysimilartoALU1_HUMANALUS 3. 6 419390 A1701162 Hs. 90207 hypothetical protein MGC1 1138 3. 6 428483 A1908539 Hs. 184592 KIAA0344 gene product 3. 6 409557 BE182896 Hs. 211193 ESTs 3. 6 418049 AA211467 Hs. 190488 Homo sapiens, Similar to nuclear localiz 3. 6 443774 AL117428 Hs. 9740 DKFZP434A236 protein 3. 6 425331 AW962128 gb : EST374201 MAGE resequences, MAGG Homo 3. 6 445105 AF238869 Hs. 283955 Homo sapiens clone GLSH-2 similar to gli 3. 6 424051 AL110203 Hs. 138411 HomosapiensmRNA ; cDNADKFZp586J1922 (f 3. 6 446420 AW015693 Hs. 135614 ESTs 3. 6 428138 AA773842 Hs. 293799 ESTs 3. 6 404185 Target Exon 3. 6 427517 AA644142 Hs. 7107 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 6 443150 A1034467 Hs. 34650 ESTs 3. 6 408065 AW954272 gb : EST366342 MAGE resequences, MAGC Homo 3. 6 435092 AL137310 Hs. 4749 Homo sapiens mRNA ; cDNADKFZp761E13121 (3. 6 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 3. 6 433560 A1925195 Hs. 130891 hypothetical protein MGC4400 3. 6 432882 NM_013257 Hs. 279696 serum/glucocorticoid regulated kinase-li 3. 6 412350 A1659306 Hs. 73826 protein tyrosine phosphatase, non-recept 3. 6 439753 BE262233 Hs. 7423 hypothetical protein from EUROIMAGE 2168 3. 6 451734 NM006176 Hs. 26944 neurogranin (protein kinase C substrate, 3. 6 437056 A1147061 gb : ok33a11. s1 Soares_NSF_F8_9W_OT_PA_P_S 3. 6 438328 A1492261 Hs. 32450 ESTs 3. 6 451489 NM005503 Hs. 26468 amyloid beta (A4) precursor protein-bind 3. 6 423641 AL137256 Hs. 130489 ATPase, aminophospholipid transporter-li 3. 6 434784 AA649051 Hs. 164007 ESTs 3. 5 441834 AL138034 Hs. 7979 KIAA0736 gene product 3. 5 421183 AL135740 Hs. 102447 TSC-22-like 3. 5 452108 AW135982 Hs. 203013 hypothetical protein FLJ12748 3. 5 425870 R13406 Hs. 56782 ESTs 3. 5 425115 R44664 Hs. 123956 ESTs 3. 5 444471 AB020684 Hs. 11217 KIAA0877 protein 3. 5 419929 U90268 Hs. 93810 cerebral cavernous maltormations 1 3. 5 407792 A1077715 Hs. 39384 putative secreted ligand homologous to f 3. 5 422564 A1148006 Hs. 222120 ESTs 3. 5 433323 AA805132 Hs. 159142 ESTs 3. 5 435743 T66861 Hs. 12962 ESTs 3. 5 450297 AW901347 Hs. 38592 hypothetical protein FLJ23342 3. 5 403341 Target Exon 3. 5 443761 A1525743 Hs. 345187 ESTs 3. 5 458743 R53169 Hs. 80712 KIAA0202 protein 3. 5 447925 AW292271 Hs. 250718 ESTs 3. 5 445424 AB028945 Hs. 12696 cortac6n SH3 domain-binding protein 3. 5 416874 H98752 Hs. 42568 ESTs 3. 5 430456 AA314998 Hs. 241503 hypothetical protein 3. 5 419647 AA348947 Hs. 91816 hypothetical protein 3. 5 412707 AW206373 Hs. 16443 Homo sapiens cDNA : FU21721 fis, clone C 3. 5

444458 BE041526 Hs. 31746 hypothe6cal protein DKFZp547F072 3. 5 451066 A1758660 Hs. 206132 ESTs 3. 5 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypotheb 3. 5 420071 AB028985 Hs. 94806 ATP-binding cassette, sub-family A (ABC1 3. 5 432625 A1243596 Hs. 94830 ESTs, Moderately similar to T03094 A-kin 3. 5 442118 AA976718 Hs. 202242 ESTs 3. 5 421686 AB011156 Hs. 106794 KIAA0584 protein 3. 5 428966 AF059214 Hs. 194687 cholesterol25-hydroxylase 3. 5 444326 A1939357 Hs. 270710 ESTs 3. 5 443361 A1792628 Hs. 133273 ESTs 3. 5 427627 R87582 Hs. 179915 guanine nucleotide binding protein (G pr 3, 4 434542 AA769310 Hs. 61260 hypothetical protein FLJ 13164 3. 4 419235 AW470411 Hs. 288433 neurotrimin 3. 4 440700 AW952281 Hs. 296184 guanine nucleotide binding protein (G pr 3. 4 417084 H08370 Hs. 33067 ESTs 3. 4 432925 AA878324 ESTs 3. 4 439920 H05430 Hs. 288433 neurotrimin 3. 4 453710 AL119136 Hs. 236131 homeodomain-interacting protein kinase 2 3. 4 412783 BE276738 Hs. 74578 DEAD/H (Asp-Giu-Aia-Asp/His) box poCypep 3, 4 435977 AL138079 Hs. 5012 brain-specific membrane-anchored protein 3. 4 431725 X65724 Hs. 2839 Nome disease (pseudoglioma) 3. 4 449611 A1970394 Hs. 197075 ESTs 3. 4 448543 AW897741 Hs. 21380 Homo sapiens mRNA ; cDNA DKFZp586P1124 (f 3. 4 430968 AW972830 gb : EST384925 MAGE resequences, MAGL Homo 3. 4 413530 AA130158 Hs. 19977 ESTs, Moderately similar to ALUB_HUMAN A 3. 4 412043 BE156622 Hs. 333371 Homo sapiens clone TA40 untranslated mRN 3. 4 445666 R59960 Hs. 282386 ESTs 3. 4 412820 BE001236 gb : CM3-BN0075-240200-101-d11 BN0075Homo 3. 4 458912 A1911066 ESTs 3. 4 452449 AW068658 Hs. 20943 ESTs 3. 4 437085 AA743935 Hs. 202329 ESTs 3. 4 419852 AW503756 Hs. 286184 hypothetical protein dJ551D2. 5 3. 4 448750 U95020 Hs. 21903 calcium channel, voltage-dependent, beta 3. 4 435741 Al240668 Hs. 113099 ESTs 3. 4 445828 F05802 Hs. 81907 ESTs 3. 4 419347 C15944 Hs. 90005 supedorcervical ganglia, neural specifi 3. 4 431733 AW298410 Hs. 21475 ESTs 3. 4 415949 H10562 Hs. 21691 ESTs 3. 4 400205 NM006265' : Homo sapiens RAD21 (S. pombe) 3. 4 437528 N59646 Hs. 169745 crumbs (Drosophila) homolog 1 3. 4 442593 R39804 Hs. 31961 ESTs 3. 4 442927 A1024347 Hs. 131519 ESTs 3. 4 429528 AI985303 Hs. 99361 ESTs 3. 4 450756 A1733488 Hs. 144062 ESTs 3. 4 437387 A1198874 Hs. 28847 AD026 protein 3. 4 430347 NM 002039 Hs. 239706 GRB2-associated binding protein 1 3. 4 404283 ENSP00000244751' : Copine-like protein KIA 3. 4 433229 AB040925 Hs. 91625 KIAA1492 protein 3. 4 440274 R24595 Hs. 7122 scrapie responsive protein 1 3. 4 436114 AA778232 Hs. 19515 ESTs, HightysimitartoNRG3_HUMANPRO-N 3. 4 439690 AA843868 Hs. 190567 ESTs 3. 4 450784 AW246803 Hs. 47289 ESTs 3. 3 417868 A1078534 Hs. 122592 ESTs 3. 3 439793 AA018825 Hs. 7934 Kruppel-like factor 4 (gut) 3. 3 456209 W60633 Hs. 297792 ESTs 3. 3 421458 NM003654 Hs. 104576 carbohydrate (keratan sulfate Gal-6) sul 3. 3 438201 AA780243 Hs. 54647 ESTs 3. 3 400302 N48056 Hs. 1915 folate hydrolase (prostate-specific memb 3. 3 425897 AA935315 Hs. 48965 Homo sapiens cDNA : FLJ21693 fis, clone C 3. 3 423169 BE047009 Hs. 21837 ESTs, Weakly similar to KIAA0927 protein 3. 3 415539 A1733881 Hs. 72472 BMP-R1B 3. 3 450337 A1693256 Hs. 202427 ESTs 3. 3 408447 AK002089 Hs. 45080 Homo sapiens cDNA FLJ11227 fis, clone PL 3. 3 423420 A1571364 Hs. 128382 Homo sapiens mRNA ; cDNA DKFZp76111224 (f 3. 3 429084 AJ001443 Hs. 195614 splicing factor 3b, subunit 3, 130kD 3. 3 440435 AL042201 Hs. 21273 transcription factor NYD-sp10 3. 3 453785 A1368236 Hs. 283732 ESTs, Moderately similar to ALU1HUMAN A 3. 3 448048 BE281291 Hs. 170408 ESTs, Moderatety similar to A47582 B-cel 3. 3 436207 AA334774 Hs. 12845 hypothetical protein MGC13159 3. 3 404632 NM022490 : Homo sapiens hypothetical prot 3. 3 411565 AW851728 gb : MR2-CT0222-011199-007-dO6 CT0222 Homo 3. 3 416845 H95279 Hs. 293788 gb : yu20hO2. s1 Soares fetal liver spleen 3. 3 436267 AW450938 Hs. 180115 ESTs 3. 3 426625 T78300 Hs. 300642 serologically defined colon cancer antig 3. 3 401272 C9000559' : gil12314195lemblCAB99338. 1l (A 3. 3 435071 D60683 Hs. 35495 ESTs 3. 3 433128 AB021923 Hs. 23367 EST-YD1protein 33 426920 AA393351 Hs. 132121 ESTs 3. 3 423668 Y10148 Hs. 131138 neurotensin receptor 2 3. 3 435056 AW023337 Hs. 5422 glycoprotein M6B 3 3 445534 AL038823 Hs. 12840 Homo sapiens germline mRNA sequence 3. 3 425010 T16837 Hs. 4241 ESTs 3. 3 445260 A1218133 Hs. 147617 ESTs 3. 3

421094 AW978202 Hs. 289064 hypothetical protein FU22251 3. 3 450358 AB010098 Hs. 24907 coronin, actin-binding protein, 2B 3. 3 411048 AK001742 Hs. 67991 hypotheticalprotein DKFZp434G0522 3. 3 432488 AA551010 Hs. 216640 ESTs 3. 3 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 3. 3 412719 AW016610 Hs. 816 ESTs 3. 3 420050 AL118615 Hs. 94653 neurochondrin 3. 3 410082 AA081594 Hs. 158311 Musashi (Drosophila) homolog 1 3. 3 408554 AA836381 Hs. 315111 nuclearreceptorco-epressorlHDAC3comp 3. 3 431462 AW583672 Hs. 256311 granin-like neuroendocrine peptide precu 3. 2 434574 A1424458 Hs. 33470 ESTs 3. 2 432715 AA247152 Hs. 200483 ESTs, Weakly similar to KIAA1074 protein 3. 2 426757 AW205640 Hs. 158206 ESTs 3. 2 428167 AA770021 Hs. 16332 ESTs 3. 2 451597 AW295250 Hs. 207536 ESTs 3. 2 400362 AF068294 Hs. 272414 Homo sapiens HDCMB45P mRNA, partial cds 3. 2 417675 A1808607 Hs. 3781 similar to murine leucine-rich epeat pr 3. 2 429550 AW293055 Hs. 119357 ESTs 3. 2 404120 C5000537' : gil3298595lgbjMC41376. 1l (AFO 3. 2 417123 BE326521 Hs. 159450 ESTs 3. 2 450313 A1038989 Hs. 332633 Bardet-Biedl syndrome 2 3. 2 425999 AW513051 Hs. 332981 ESTs, Weakly similar to 138022 hyptheti 3. 2 430526 AF181862 Hs. 242407 G protein-coupled receptor, family C, gr 3. 2 452619 AW298597 Hs. 61884 Homo sapiens, clone IMAGE : 4298026, mRNA, 3. 2 415558 AA885143 Hs. 125719 ESTs 3. 2 451996 AW514021 Hs. 245510 ESTs 3. 2 420560 AW207748 Hs. 59115 ESTs 3. 2 432328 A1572739 Hs. 195471 6-phosphofructo-2-kinase/fructose-2, 6-bi 3. 2 417404 NM 007350 Hs. 82101 pleckstrinhomology-likedomain, family 3. 2 414300 A1304870 Hs. 188680 ESTs 3. 2 437834 AA769294 Hs. 283854 gb : nz36g03. s1 NCI_CGAP_GCB1 Homo sapiens 3. 2 430694 AA810624 Hs. 30936 ESTs, Weakly similar to H2BH_HUMAN HISTO 3. 2 447714 AW296313 Hs. 255537 ESTs 3. 2 412021 AW885592 gb : RC4-OT0071-090300-011-g1 OT0071 Homo 3. 2 443431 A1056847 Hs. 20654 ESTs 3. 2 445774 A1254165 Hs. 339968 ESTs 3. 2 431327 AW972220 Hs. 105426 ESTs 3. 2 413335 A1613318 Hs. 48442 ESTs 3. 2 430809 A1791150 Hs. 262009 ESTs, Moderately similar to 138022 hypot 3. 2 445858 AL133811 solutecanierfamily1 (gíialhighaffh 3. 2 450692 H50603 Hs. 94037 hypotheticat protein FLJ23053 3. 2 439039 A1656707 Hs. 48713 ESTs 3. 2 401720 NM014587' : Homo sapiens SRY (sex determi 3. 2 453740 AL120295 Hs. 311809 ESTs, Moderately similar to PC4259 feni 3. 2 451032 W03692 Hs. 323079 Homo sapiens mRNA ; cDNA DKFZp564P116 (fr 3. 2 413834 BE296896 Hs. 224179 ESTs, Weakly similar to 138022 hypotheb 3. 2 438138 R98299 Hs. 177502 ESTs 3. 2 436338 W92147 Hs. 118394 ESTs 3. 2 417169 R13550 Hs. 246773 ESTs 3. 2 424066 Z99348 Hs. 112461 ESTs, Weakly similar to 138022 hypotheti 3. 2 435767 H73505 Hs. 117874 ESTs 3. 2 415314 N88802 Hs. 5422 glycoprotein M6B 3. 2 448475 BE613134 Hs. 247474 hypothetical protein FLJ21032 3. 2 414699 A1815523 Hs. 76930 synuclein, alpha (non A4 component of am 3. 2 438549 BE386801 Hs. 21858 trinudeotide repeat containing 3 3. 2 453896 AW293483 Hs. 255205 KIAA1853 protein 3. 2 419539 AF070590 Hs. 90869 Homosapiensclones24622and24623mRNA 3. 1 428832 AA578229 Hs. 324239 ESTs, ModeratelysimilartoZN91_HUMANZ 3. 1 446636 AC002563 Hs. 15767 citron (rho-interacbng, serine/threonin 3. 1 429046 X57436 Hs. 194772 oligodendrocyte myelin glycoprotein 3. 1 421896 N62293 Hs. 45107 ESTs 3. 1 413995 BE048146 Hs. 75671 syntaxin 1A (brain) 3. 1 414734 AA151712 Hs. 82572 ESTs 3. 1 446147 AL133064 Hs. 14051 HomosapiensmRNA ; cDNADKFZp434A2417 (f 3. 1 427712 A1368024 Hs. 283696 ESTs 3. 1 406481 Target Exon 3. 1 453204 R10799 Hs. 191990 ESTs 3. 1 422890 Z43784 ankyrin 3, node of Ranvier (ankyrin G) 3. 1 422991 H10940 Hs. 48965 Homo sapiens cDNA : FLJ21693 fis, clone C 3. 1 421030 AW161357 microtubule-associated protein tau 3. 1 423603 AB007880 Hs. 129883 Homo sapiens KIAA0420 mRNA, complete cds 3. 1 413985 A1018666 Hs. 75667 synaptophysin 3. 1 431721 AB032996 Hs. 268044 KIAA1170 protein 3. 1 434164 AW207019 Hs. 148135 serine/theoninekinase33 3. 1 429876 AB028977 Hs. 225974 KIAA1054 protein 3. 1 423175 W27595 Hs. 347310 hypothetical protein FLJ14627 3. 1 412799 Al267606 gb : aq91hO3. x1 Stanley Frontal SB pool 1 3. 1 459318 NM 000038 gb : Homo sapiens adenomatosis polyposis c 3. 1 453324 W26592 Hs. 232089 ESTs 3. 1 424009 F11690 gb : HSC30D041 normalized infant brain cDN 3. 1 436222 A1208737 Hs. 122810 HomosapienscDNAFU11489fis, doneHE 3. 1 414884 R54418 Hs. 183745 hypothetical protein FLJ13456 3. 1 446862 AV660697 Hs. 282700 ESTs 3. 1

427241 AA399988 Hs. 112087 Human DNA sequence from clone RP11-530N1 3. 1 455388 AW936234 gb : QVO-DT0020090200-106gO5DT0020Homo 31 415838 R44336 Hs. 7093 ESTs 3. 1 451692 AL137422 Hs. 26849 Homo sapiens mRNA : cDNA DKFZp761A1623 (f 3. 1 445294 Z45978 Human clone 23826 mRNA sequence 3. 1 434460 AA478486 Hs. 3852 KIAA0368 protein 3. 1 449919 A1674685 Hs. 200141 ESTs 3. 1 440688 AW404591 Hs. 147440 ESTs, WeaklysimilartoZ192 HUMANZINC 3. 1 416801 X98834 Hs. 79971 sal (Drosophila)-like 2 3. 1 428060 AA420616 Hs. 249483 ESTs 3. 1 423597 AL043117 Hs. 129872 sperm associated antigen 9 3. 1 452454 AW820480 gb : QV2-ST0298-140200-042-f10 ST0298 Homo 3. 1 445337 NM 013280 Hs. 12523 fibronectinteucinenehtransmembranep 3. 1 413974 BE208636 Hs. 27788 ESTs 3. 1 422772 AL119585 Hs. 120228 KIAA0749 protein 3. 1 423872 AB020316 Hs. 134015 uronyl 2-sulfotransferase 3. 1 435375 Api733610 Hs. 187832 ESTs 3. 1 450661 AW952160 Hs. 83849 ESTs 3. 1 428647 AA830050 Hs. 124344 ESTs 3. 1 400658 ENSP00000237081' : KIAA1217 PROTEIN (FRAGM 3. 0 443845 AI590084 Hs. 148485 ESTs, Weakly similar to A47161 Mac-2-bin 3. 0 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponfin, 3. 0 433980 AA137152 Hs. 286049 phosphoserine aminotransferase 3. 0 437738 AA766914 Hs. 203475 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 0 444772 AW450800 Hs. 176859 ESTs 3. 0 453825 AL157475 Hs. 35453 Homo sapiens mRNA ; cDNADKFZp761G151 (fr 3. 0 439971 W32474 Hs. 301746 RAP2A, member of RAS oncogene family 3. 0 408449 Nom-004408 Hs. 166161 dynamin 1 3. 0 432821 BE170702 Hs. 279005 solutecarierfamily21 (organicanion 3. 0 453657 W23237 Hs. 296162 AD037 protein 3. 0 407235 D20569 Hs. 169407 SAC2 (suppressor of act'n mutations 2, y 3. 0 428862 NM 000346 Hs. 2316 SRY (sex determining region Y)-box 9 (ca 3. 0 424726 AK001007 Hs. 138760 Homo sapiens cDNA FW 10145 hs, clone HE 3. 0 454253 AV660717 Hs. 47144 DKFZP586N0819 protein 3. 0 450650 T65617 Hs. 101257 hypothetical protein MGC3295 3. 0 418211 BE244746 Hs. 247474 hypotheticalprotein FU21032 3. 0 440461 R52728 Hs. 7193 KIAAL 183 protein 3. 0 452850 H23230 Hs. 22481 ESTs, Moderately similar to A46010 X-lin 3. 0 431431 AL096711 Hs. 252953 HumanDNAsequencehromcloneRP3-403A15 3. 0 447881 BE620886 Hs. 75354 GCN1 (genera'control of amino-acid synt 3. 0 454042 H22570 hypothetical protein FU20093 3. 0 429168 AA984682 Hs. 146589 ESTs, Weakly similar to JC5238 galactosy 3. 0 451391 AA017410 Hs. 40568 ESTs 3. 0 446377 AW014022 Hs. 170953 ESTs 3. 0 430251 AA609246 Hs. 181451 ESTs 3. 0 420658 AW965215 Hs. 130707 ESTs 3. 0 454119 BE549773 Hs. 40510 uncoupling protein 4 3. 0 451018 AW965599 Hs. 247324 mitochondrial ribosomal protein S14 3. 0 435321 R16814 Hs. 112062 ESTs 3. 0 412494 AL133900 Hs. 792 ADP-ribosylation factor domain protein 1 3. 0 423858 AL137326 Hs. 133483 HomosapiensmRNA ; cDNADKFZp434B0650 (f 3. 0 431242 AA987742 Hs. 347534 KIAA1201 protein 3. 0 403022 C21000178' : gil7341207lgblMF61215. 1 jAF22 3. 0 445899 A1263736 Hs. 145626 ESTs 3. 0 440261 M81886 Hs. 7117 glutamate receptor, ionotropic, AMPA 1 3. 0 446809 AW590171 Hs. 101413 ESTs 3. 0 434269 AK001991 Hs. 3781 similartomunneleucine-richepeatpr 3. 0 418951 F07809 Hs. 89506 paired box gene 6 (aniridia, keratitis) 3. 0 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 3. 0 432229 AW290976 Hs. 143587 ESTs 3. 0 443726 A1083825 Hs. 148382 ESTs 3. 0 TABLE 138 : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408065 103646 1 AW954272 A1003154 AA059300 AA046911 410099 117647_1 M081630 T08671 Al174254 D83874 AW959843 AA364503 AA693467 AW993370 BE327037 AA167714 N79906 AW901977 AW901980 W52882 T07735 AA484549 W60090 D52685 T23811 BE327043 AW901768 BE551237 AA917004 AA716027 AI439658 AA283724 AI805992 AI457096 AA084618 BE467736 A1092635 AI887863 AI697593 AA436618 A1167419 AI418634 T31586 AA436630 AA706191 A1041169 Al422304 T03534 AA211402 AI204899 AI366472 AW827081 AA788593 T32736 A1767935 AA167791 AA747914 AA663870 A1865504 410126 117761 1 BE169274 AW893230 AA210998 H24222 AA081774 BE000935 BE000834 AA334880 411565 1249756 1 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628 411775 125757_1 H08342 R52430 Z42067 M095285 412021 1272156_1 AW885592AW885594AW885579AW885651 412799 132817 1 Al267606M121045M126521 412811 132943 1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 A1424991 A1693507 A1863108 AA599NO A1091148 AA598689 R39887 AA813482 AW016452 H06383 R41807 A1364268 M620528 A1241940 AW089149 AW090733 AW088875138240 AA121202 R17734 412820 1330039_1 BE001236 BE001177 BE001180 BE001234 415131 1523680 1 D61119 D81508 D81734

418512 176394J AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074 AW890649 420111 190755-1 AA255652 AA28091 1 AW967920 AA262684 420352 192979 1 BE258835 AW968316 AA258918 AW843305 R14744 Al580388 BE071923 R36280 421030 19864-1 AW161357 A1879062 A1928938 AW161097 AW161167 BE314465 AA351715 F07096 AA179034 F08510 F00653A1936671 AA476718AW772454 Al807703 R44253M976667 A1985186 A1650254 H38942 R84829 AA018724 AA001000 H85934 AA019126 H85609 AA017000 AA339355 AW950556 051397 AA213981 BE548002 A1056359 AA001560 AW952113 AA317769 AI857477 AI857475 AW249771 AWt62661 H38943 AA018628 R85885 Al984613 Al934765 Al796172 AW157488 Al929191 R85523 D51221 D53851 H85610 AI749674 F21582 AA323145 AA019127 AA687444 T06745 A1699293 H29532 M214023 M223656 NM_016834 X14474 R19697 H09695 R17455 R13812 R19056 Al681231 Al590200 R37671 AA861828 A1990023 At935669 AW00582 1 M324581 H 17335 R37659 R42802 R46242 R60936 R59731 H28993 AA479907 R44570 AI890696 AA308884 AA507078 R41274 A1365507T16348AtS60453 F03259 F04722 T16312M016081 AW073061 BE314824W28930 R44098 R51045 422890 222707_1 Z43784 R13382 AW572911 M449369 H17037 R19603A1632565AW004030 BE502530Z25032 M805324 M449241 A1651825 Al264863 AW196918 AA948267A1953735A1263703AA319159AW964436A1903440AW594171 A1867447 AW204071 AW956110 C15616 D81142 H17038 AW162343 T87230 Al366013 H10064 A1190479 Al093318 A1867923 BE219303 BE048820 Al198397 M654667 Z39851 F02655 Z28734 F04161 T16575 F10145 AA318815 R40898 423476 22861 1 AL035633 F71794 Ft1783 H18042 T66089 H29379 Rt9493 AW134660 AI299437 AL133995 AA057405 N78351 AA917450 A1002692 T09262 T65008 H29290 A1200874 AA894415 A1732887 A1791768 A1733447 AA9BB785 N62128 T09261 AW956936 424009 234177 1 F11690 AW965370 AA333586 D30830 424572 24097_1 M19650 R18810 R18721 AW896146 AW889520 AA192362 AA176814 F12085 BE255264 BE251393 T65248 M380585 AA380465 BE408684 AA459037 AW498869 AA776107 BE274289 D45269 M61958 AA378818 AW663180 AW672958 H08611 M78164 BE393721 AA348660 R36303 AW498662 AA019090 AA001087 AA054302 AA019775 AA018808 AA019132 AI858240 R73218 H30477 H17776 AA659570 BE276750 AL118657 AA375861 M352427AW581695 Al141183 N63474 AA654162 H17659 AL120696 T28867 AW498868 A1355918 AA902349 AA569098 A1088231 A1042604 AA555133 AI183611 AI608822 AI275941 AW316805 AA349486 AI355233 R85117 AW613626 R49234 AA458846 N20669 H18693 AA977567 T15423 AW002084 Al824721 N36242 Al417281 Al018212 M912337 F09722 AA749449 AW879172M885427M916639 Al872560 F00482 H45184 AI217251 AA775807 BE390071 AA303517 AA001050 BE515169 N44066 AL133684 Al807085 M808009 M915914 F00007 AA019749 AL121560 AW675544 AW090233 AW072071 A1810932 A1089733 AW026222 M770155 A1089647 A1085733 AW516061 AL037636 AL037635 Al863947 H50420 R11203 AA019133 N94772 N71842 N29047 AA778138 AA554336 AA179865 N59453 T65212 AA054270 AW806630M533375 D13146 M349487 AU077160 BE255671 BE276795 BE250823 AL120301 BE311390 BE252483 424945 245223_1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 AI341345 AW298800 AA724961 AA931158 AA41227 A1806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 AI492961 A1361526 F04002 AA452141 T23551 AI472655 At193667 Al341984 N92658 T32870 R52664 N50428 AW089291 Al934175 A1423737 D60665 425331 250199_1 AW962128 AA355353 AA427363 426413 266650 1 AA377823 AW954494 A1022688 426503 268283 1 AA380153 AA380233 AW963529 426919 273507 1 AL041228 D82004 D61361 AI203314 AI990307 AW900295 A1018308 AW087473 AW183530 AA393346 H50055 AA935601 428342 290035_2 A1739168 AA426249 AI199636 AW505198 AW977291 AA824583 AA883419 AA724079 A1015524 AI377728 AW293682 AI928140 AA731438 A1092404 A1085630 AA731340 429007 298301_1 D80642 M4U145 AL119015 AW904500 429421 30431_1 AL031653 Al693758 AL040619 AW977914 AA811957 Al352198 AW104364 M648367 M897604 AW341668 Al201382AL040620 430183 31412 2 BE010033 M676833 Al311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 A1936370 AA552514 T67280 AA039909 430676 32168-1 AF084866 AF084870 AF084864 AF084867 AF084869 AF084865 AF084868 AW818206 AW812038 BE144813 BE144812 AW812041 AW812040 AW812067 BE061583 BE061604 T05808 Al352469 M580921 BE141783 BE141782 BE061601 AW814393 AW885029 430968 326269 1 AW972830 AA527647 AA489820 AA570362 432646 351909J AW753310AW974000AA557840AA558570AW751539 432925 356372 1 AA878324 A1863159 A1619686 AA570406 A1014377 433009 3573711 AA761668 AA573621 R92814 R09670 433523 368873 1 H29882 AW665533 AW149901 AI572917 AA598500 AI686466 AI336390 AW864390 AW864320 437034 431713_1 M742643M808575AW976668 437056 432262 1 Al147061 AA743380 AA765223 AW976398 A1803927 438458 457837 1 AW975186 AA807807 D29548 439285 47065_1 AL133916 N79113 AF086101 N76721 AW950828 AA364013 AW955684 AI346341 AI867454 N54784 A1655270 A1421279 AW014832M775552 N62351 N59253 AA626243 Al341407 BE175639 AA456968 AI358918 AA457077 441102 509604 1 AA973905 A1299888 AA917019 H63235 T90771 445294 6352_1 Z45978 U79248 T77277 R24952 AA361008 AW953678 T10376 AW860579 AW860657 AW364889AW860635 AW860658 AW905164 W21226 AA448954 W69484 AA993098 AA287413 AA449682 Api961815 W57612 AW271363 R45215 AW136256 A1865103 W69577 A1961826AA747542 M173746 A1961816 F07706 R39461 F04829 F05938 AA172385 445858 6525 1 AL133811 M78538 T07792 AW895859 AW895589 ALt 19422 T79876 R19494 AF131756 H18570 T08285 F11532 Z42038 AW961964 AA683391 M62092 AL119616 Z21141 AA663820Z19748 H18462 AL120152 R43841 R37594 AA775980 F09194 A1207884 Z38142 F01555 AA020737 AL120362 AW952737 T04912 446692 689623 1 Z44514 Al352097 A1803984 AW235923 AW196558 A1954637 Al336983 447197 711623 1 R36075 A1366546 R36167 448044 747196_1 Al458632 H24240 R14537 R18426 AW867082 450582 83933 1 AI339732 AA010300 AW515041 AA768334 N29860 AA425874 AA425118 AA865829 AW936878 451320 86576 1 AW118072 A1631982 Tt5734 AA224195 AI701458 W20198 F26326 AA890570 N90552 AW071907 A1671352 A1375892 T03517 R88265 All 24088 AA224388 A1084316 A1354686 T33652 AI140719 AI720211 T03490 A1372637 T15415 AW205836 AA630384 T03515 T33230 AA017131 AA443303 T33623 A1222556 T33511 T33785 A1419606 D55612 452454 918306_1 AW820480AW820288A1902522 453739 979419 1 AL120266AW269469AW890114 454042 996363 H22570 AW292267 AW137298 AW874199 A1206120 H45263 AA788851 R49056 AW241428 A1921013 AW129293 A1684910 BE466753 AA340613 AW025969AI202561 Al243913 AW771106 F04969 A1654847 AI494436 AW771447 AW103715 N64350 AA347011 Al431587 AA779107 AA041195 Al358894 A1421678 A1018523 AA707199 AA410309 AI366468 AW020049 A1880103 AL119553 R42410 R55722 T66767 R43035 H17396 H45331 F01659 Z38381 M708686 A1081305 R53955 M041432 W27787 454171 1049240 1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 455388 1287904 1 AW936234 AW936074 AW936181 AW936179 AW936217 AW936077 AW936227 AW936191 455646 1348557 1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 458912 8231 04_1 A1911066 A1933734 A1680888 AJ003599 459079 8887101 A1821122 A1821866 TABLE 13C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 2Z Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted.

Nt_pasiGon : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 400533 6981826 Minus 277132-277595 400658 8118459 Minus 73525-73644 400777 8131663 Plus 70745-71121 401272 9797373 Minus 98374-98509 401720 6468551 Plus 77838468 402145 8018280 Pius 113086-114800 402604 9909420 Plus 20393-20767 402605 9909420 Minus 47680-47973 402855 9662953 Minus 59763-59909 403022 3132351 Plus 92097-92864 403142 9444521 Plus 89286-90131 403341 8569175 Plus 30699-30910 403696 3135242 Minus 143467-143634 404120 7342152 Plus 13577S136000 404185 4572584 Minus 129171-129327 404283 2276311 Minus 99460-99564 404541 8318559 Plus 103456-103664 404584 9857511 Plus 138651-139153 404632 9796668 Plus 45096-45229 404819 4678240 Plus 1622316319, 16427-16513, 1673616859, 16941-17075, 17170-17287, 17389-17529, 18261-18357, 1844318578 405238 7249119 Minus 51728-51836 405239 7249119 Plus 144345-144464. 144690-144836, 151750-151883, 152407-152484 405348 2914717 Minus 43310-43462 405819 4007557 Plus 2830-2967 406481 9864741 Minus 91439-91579 TABLE 14A : ABOUT 1111 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL CENTRAL NERVOUS SYSTEM Table 14A lists about 1111 genes up-regulated in glioblastoma compared to normal centrat nervous system (CNS). These were selected from 59680 probesets on the Ah'ymetrix/Eos Hu03 GeneChip array such that the ratio of'average'glioblastoma to"average"CNS tissues was greater than or equal to 2. 5. The'average"glioblastoma level was set to the 85" percent amongst various brain tumors. The'average'normal CNS tissue level was set to the 85"percentiie amongst various CNS tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10^ pencen6te value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene U6e R1 : Ratio of GLIOBLASTOMA to CNS Pkey ExAccn UnigenelD Unigene Title Rl 422737 M26939 Hs. 119571 collagen, type 111, alpha 1 (Ehlers-Danl 32. 8 423961 D13666 Hs. 136348 periostin (OSF-2os) 28. 0 433001 AF217513 Hs. 279905 clone HCiO310 PR00310p1 25. 3 414555 N98569 Hs. 76422 phospholipase A2, group IIA (piatelets, 24. 3 424800 AL035588 Hs. 153203 MyoD family inhibitor 22. 6 417308 H60720 Hs. 81892 KIAA0101 gene product 22. 2 449539 W80363 Hs. 58446 ESTs 20. 7 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 18. 7 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 18. 6 444190 A1878918 Hs. 10526 cysteine and glycine-rich protein 2 17. 2 412420 AL035668 Hs. 73853 bone morphogenetic protein 2 16. 7 417130 AW276858 Hs. 81256 S100 calcium-binding protein A4 (calcium 16. 7 414217 A1309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 14. 3 431941 AK000106 Hs. 272227 Homo sapiens cONA FLJ20099 fis, clone CO 14. 3 425397 J04088 Hs. 156346 topoisomerase (DNA) tlapha (170kD) 14. 1 446584 U53445 Hs. 15432 downregulated in ovarian cancer 1 13. 9 422672 X12784 Hs. 119129 collasqensqpelvapha1 13. 6 402604 Target Exon 13. 6 424635 AA420687 Hs. 115455 Homo sapiens cDNA FLJ 14259 hs, clone PL 13. 0 428330 L22524 Hs. 2256 matrixmetalloproteinase7 (matrilysin, 12. 9 434078 AW880709 Hs. 283683 chromosome 8 open reading frame 4 12. 5 414761 AU077228 Hs. 77256 enhancer of zeste (Drosophila) homolog 2 12. 4 442432 BE093589 Hs. 38178 hypothetical protein FLJ23468 12. 2 456759 BE259150 Hs. 127792 delta (Drosophila)-like 3 12. 1 409638 AW450420 Hs. 21335 ESTs 11. 5 441269 AW015206 Hs. 178784 ESTs 10. 5 435020 AW505076 Hs. 301855 DiGeorge syndrome critical region gene 8 10. 5 422163 AF027208 Hs. 112360 prominin (mouse)-tike1 10. 1 444969 A1203334 Hs. 160628 ESTs 10. 1 430132 AA204686 Hs. 234149 hypothetical protein FLJ20647 9. 9 433437 U20536 Hs. 3280 caspase 6, apoptosis-related cysteine pr 9. 4 445101 T75202 Hs. 12314 Homo sapiens mRNA ; cDNA DKFZp586C1019 (f 9. 2 413929 BE501689 Hs. 75617 collagen, type IV, alpha 2 9. 1 425187 AW014486 Hs. 22509 ESTs 9. 1 449722 BE280074 Hs. 23960 cyclin B1 8. 9 449611 A1970394 Hs. 197075 ESTs 8. 9 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 8. 9 419239 AA468183 Hs. 184598 Homo sapiens cDNA : FU23241 fis, clone C 8. 9 443731 A1083928 Hs. 145418 ESTs 8. 8 402855 NM_001839-: Homosapienscalpnin3, æid 8. 7

447342 A1199268 Hs. 19322 Homo sapiens, Similar to RIKEN cDNA 2010 8. 6 410102 AW248508 Hs. 279727 ESTS ogueofPEM-3 [Cionasavignyi 8. 5 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 8. 4 417426 NM_002291 Hs. 82124 laminin, beta 1 8. 4 433800 A1034361 Hs. 135150 lung qpe-l cetl membrane-associated gty 8. 3 417061 A1675944 Hs. 188691 Homo sapiens cDNA FLJ12033 fis, clone HE 8. 1 409461 AA382169 Hs. 54483 N-myc (and STAT) interactor 8. 1 414622 A1752666 Hs. 76669 nicotinamide N-methyttransferase 8. 1 430691 C14187 Hs. 103538 ESTs 8. 0 447726 AL137638 Hs. 19368 math) 2 8. 0 417043 NM004369 Hs. 80988 collagen, type VI, alpha 3 7. 9 447004 AW296968 Hs. 157539 ESTs 7. 9 409799 D11928 Hs. 76845 phosphosefine phosphatase-like 7. 8 426075 AW513691 Hs. 270149 ESTs, Weakly similar to 2109260A B cell 7. 8 419938 AU076772 Hs. 1279 complementcomponent1, rsubcomponent 7. 7 419508 AW997938 Hs. 90786 ATP-binding cassette, sub-family C (CFTR 7. 7 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAA1330 protein 7. 5 436291 BE568452 Hs. 344037 protein regulator of cytokinesis 1 7. 5 422048 NM012445 Hs. 288126 spondin 2, extracellular matrix protein 7. 5 406972 M32053 gb : Human H19 RNA gene, complete cds. 7. 4 442802 AL133035 Hs. 8728 hypothetical protein DKFZp434G171 7. 4 427581 NM 014788 Hs. 179703 Kit0129 gene product 7. 3 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 7. 3 409902 A1337658 Hs. 156351 ESTs 7. 3 418113 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 7. 2 449961 AW265634 Hs. 133100 ESTs 7. 2 418203 X54942 Hs. 83758 CDC28 protein kinase 2 7. 2 424840 D79987 Hs. 153479 extra spindle poles, S. cerevisiae, homo 7. 2 428728 NM_016625 Hs. 191381 hypothetical protein 7. 1 429183 AB014604 Hs. 197955 KIAA0704 protein 7. 1 439451 AF086270 Hs. 278554 heterochromaun-like protein 1 7. 1 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 7. 0 406850 Al624300 Hs. 172928 collagen, type 1, alpha 1 7. 0 453941 U39817 Hs. 36820 Bloom syndrome 6. 9 425234 AW152225 Hs. 165909 ESTs, Weaktysimilartol38022hypothe6 6. 9 421977 W94197 Hs. 110165 ribosomal protein L26 homoiog 6. 8 411078 A1222020 Hs. 182364 CocoaCrisp 6. 7 427019 AA001732 Hs. 173233 hypothetical protein FU10970 6. 7 448769 N66037 Hs. 38173 ESTs 6. 7 418400 BE243026 Hs. 301989 KIAA0246 protein 6. 6 408161 AW952912 Hs. 300383 hypothetical protein MGC3032 6. 6 440210 AW674562 Hs. 125296 ESTs 6. 6 437036 A1571514 Hs. 133022 ESTs 6. 6 411968 A1207410 Hs. 69280 Homo sapiens, clone IMAGE : 3636299, mRNA, 6. 6 416658 U03272 Hs. 79432 fibrillen 2 (congenital contractural ara 6. 6 449300 A1656959 Hs. 346514 ESTs 6. 5 440052 Al633744 Hs. 195648 ESTs, Weakly similar to 138022 hypotheb 6. 5 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 6. 5 434808 AF155108 Hs. 256150 Homosapiens, SimilartoRtKENcDNA2810 6. 5 452461 N78223 Hs. 108106 transcription factor 6. 5 408243 Y00787 Hs. 624 interieukin 8 6. 5 424954 NM000546 Hs. 1846 tumor protein p53 (Li-Fraumeni syndrome) 6. 4 450375 AA009647 a disintegnn and metaltoproteinase doma 6. 4 406478 Target Exon 6. 4 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 6. 4 439710 AF086543 gb : HomosapiensfulilengilhinsertcDNA 6. 4 458814 A1498957 Hs. 170861 ESTs, Weakly similar to 1195_HUMAN ZINC 6. 4 410276 Arts54545 Hs. 68301 angiopoietin-2 6. 4 425289 AW139342 Hs. 155530 interferon, gamma-inducible protein 16 6. 3 427871 AW992405 Hs. 59622 Homo sapiens, clone IMAGE : 3507281, mRNA, 6. 3 436895 AF037335 Hs. 5338 carbonic anhydrase Xll 6. 3 447458 A1741082 Hs. 158961 ESTs 6. 3 447439 AA313565 Hs. 145020 ESTs, Weakly similar to KIAA1205 protein 6. 3 413719 BE439580 Hs. 75498 smail inducible cytokine subfamily A (Cy 6. 3 449969 AW295142 Hs. 180187 Homo sapiens cDNA FW14337 hs, clone PL 6. 2 440704 M69241 Hs. 162 insulin-like growth factor binding prote 6. 2 400419 AF084545 Target 6. 2 412140 AA219691 Hs. 73625 RAB6 interac6ng, kinesin-like (rabkines 6. 2 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 6. 2 424085 NM 002914 Hs. 139226 replication (actor C (activator 1) 2 (40 6. 2 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxyla6ng ; 6. 1 430630 AW269920 Hs. 2621 cystatin A (stefin A) 6. 0 410064 X53416 Hs. 195464 filamin A, alpha (actin-binding protein-6. 0 432281 AK001239 Hs. 274263 hypothetical protein FU10377 6. 0 413627 BE182082 Hs. 246973 ESTs 6. 0 413063 AL035737 Hs. 75184 chiGnase 3-like 1 (cartilage glycoprote 5. 9 421899 AJ011895 Hs. 109281 Nef-associated factor 1 5. 9 407182 AA312551 Hs. 230157 ESTs 5. 9 410286 A1739159 Hs. 61898 DKFZP586N2124 protein 5. 9 409829 M33552 Hs. 56729 lymphocyte-specific protein 1 5. 9 446657 At335191 Hs. 260702 ESTs, Weakly similar to 2109260A B cell 5. 8 418097 R45137 Hs. 21868 ESTs 5. 8 428450 NM014791 Hs. 184339 KIAA0175 gene product S. g

419741 NM007019 Hs. 93002 ubiqui6n camer protein E2-C 5 7 421988 AW450481 Hs. 161333 ESTs 5. 7 422283 AW411307 Hs. 114311 CDC45 (cell division cycle 45, S. cerevis 5. 7 416111 AA033813 Hs. 79018 chromatin assembly factor 1, subunit A (5. 7 434846 AW295389 Hs. 119768 ESTs 5. 7 412567 A1750979 Hs. 74034 Homosapiensclone24651 mRNAsequence 5. 7 452372 A1885742 Hs. 228474 ESTs 5. 6 443247 BE614387 Hs. 333893 c-Myc target JP01 5. 6 423198 M81933 Hs. 1634 cell division cycle 25A 5. 6 445873 AA250970 Hs. 251946 poly (A>binding protein, cytoplasmic 1-l 5. 6 437034 AA742643 gb : ny91c01. s1 NCI_CGAP_GCB1 Homosapiens 5. 6 429447 AW812452 Hs. 83286 ESTs, Weakly similar to S14747 sphingomy 5. 6 424687 J05070 Hs. 151738 matrixmetalloproteinase9 (gela6naseB 5. 6 437695 AA769202 Hs. 192142 ESTs 5. 6 426935 NM 000088 Hs. 172928 collagen, type 1, alpha 1 5. 6 453361 AA035197 Hs. 107375 ESTs 5. 5 418293 A1224483 Hs. 16063 hypotheticalprotein FU21877 5. 5 405348 C7001664 : gil12698061ldbjlBAB21849. 1l (AB 5. 5 458079 Api796870 Hs. 54277 DNA segment on chromosome X (unique) 992 5. 4 452799 A1948829 Hs. 213786 ESTs 5. 4 448935 AL078596 Hs. 22591 nuclear receptor subfamily 2, group E, m 5. 4 422809 AK001379 Hs. 121028 hypothe6cal protein FU10549 5. 4 442547 AA306997 Hs. 217484 ESTs, Weakly similar to ALU1 FIUMAN ALU S 5. 4 424009 F11690 gb : HSC30D041 normalized infant brain cDN 5. 4 440332 A1218517 Hs. 188051 ESTs 5. 4 422094 AF129535 Hs. 272027 F-box only protein 5 5. 4 443884 N20617 Hs. 194397 leptin receptor 5. 4 422493 AW474183 Hs. 250173 hypothetical protein FW13158 5. 4 432731 R31178 Hs. 287820 fibronectin 1 5. 4 426108 AA622037 Hs. 166468 programmed cell death 5 5. 3 407624 AW157431 Hs. 248941 ESTs 5. 3 411048 AK001742 Hs. 67991 hypothetical protein DKFZp434G0522 5. 3 412471 M63193 Hs. 73946 endothelial cell growth factor I (platel 5. 3 414020 Nom-002984 Hs. 75703 small inducible cytokine A4 (homologous 5. 2 414774 X02419 Hs. 77274 plasminogen activator, urokinase 5. 2 413786 AW613780 Hs. 13500 ESTs 5. 2 454860 AW835767 gb : QV4-LT0016-240200-110-bO3LT0016Homo 5. 2 428037 N47474 Hs. 89230 potassium intermediate/small conductance 5. 2 420311 AW445044 Hs. 38207 HumanDNAsequencehomcloneRP4-530115 5. 1 416737 AF154335 Hs. 79691 LIM domain protein 5. 1 445837 A1261700 Hs. 145544 ESTs 5. 1 425882 U83115 Hs. 161002 absent in melanoma 1 5. 1 415682 A1347128 Hs. 191870 ESTs 5. 1 414053 BE391635 Hs. 75725 transgelin 2 5. 1 453884 AA355925 Hs. 36232 KIAA0186 gene product 5. 1 431512 BE270734 Hs. 2795 lactate dehydrogenase A 5, 1 432593 AW301003 Hs. 51483 ESTs, Weakly similar to hypothetical pro 5. 0 433323 AA805132 Hs. 159142 ESTs 5. 0 443744 A1084326 Hs. 271548 ESTs, Weaklysimilartol78835serine/th 5, 0 410434 AF051152 Hs. 63668 toll-like receptor 2 5. 0 420018 U56387 Hs. 94376 proprotein convertase subtilisin/kexin t 5. 0 419485 AA489023 Hs. 99807 ESTs, Weakly similar to unnamed protein 4. 9 446131 NM 000929 Hs. 290 phospholipase A2, group V 4. 9 412777 A1335773 Hs. 270123 ESTs 4. 9 449246 AW411209 Hs. 23363 hyptheticalproteinFW10983 4. 9 433244 AB040943 Hs. 271285 KIAA1510 protein 4. 9 407235 D20569 Hs. 169407 SAC2 (suppressor of actin mutations 2, y 4. 9 445118 A1208762 Hs. 345572 ESTs 4. 9 417404 NM 007350 Hs. 82101 pleckstrinhomology-likedomain, family 4. 9 420092 AA814043 Hs. 88045 ESTs 4. 9 412811 H06382 ESTs 4. 9 436607 AW661783 Hs. 211061 ESTs 4. 9 438456 AA913381 Hs. 20594 ESTs 4. 9 443883 AA114212 Hs. 9930 senne (orcysteine) proteinaseinhibito 4. 9 431553 X78075 Hs. 2799 cartilage linking protein 1 4. 9 439999 AA115811 Hs. 6838 ras homolog gene family, member E 4. 9 411252 AB018549 Hs. 69328 MD-2 protein 4. 9 444381 BE387335 Hs. 283713 ESTs, Weakly similar to S64054 hypotheti 4. 8 429433 AA452899 Hs. 213586 ESTs, Weakly similar to Kit1353 protein 4. 8 403349 NM_001406 ephrin-B3 4. 8 402274 C19000498-: gil45671 79lgbMD23607. 1 IACOO 4. 8 426044 AA502490 Hs. 170290 ESTs 4. 8 423600 A1633559 Hs. 310359 ESTs 4. 8 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring tinge 4. 8 431117 AF003522 Hs. 250500 delta (DrosophilaFlike 1 4. 8 418054 NM 002318 Hs. 83354 lysyl oxidase-like 2 4. 7 441703 AW390054 Hs. 192843 leucine zipper protein FKSG14 4. 7 439627 BE621702 Hs. 29076 hypothetical protein FU21841 4. 7 445900 AF070526 Hs. 125036 Homo sapiens clone 24787 mRNA sequence 4. 7 435937 AA830893 Hs. 119769 ESTs 4. 7 403961 Target Exon 4. 7 407862 BE548267 Hs. 337986 Homo sapiens cDNA FW10934 hs, clone OV 4. 6 408523 AW833259 Hs. 314287 ESTs 4. 6

403481 Target Exon 4. 6 423529 T87318 Hs. 120411 ESTs 4. 6 416847 L43821 Hs. 80261 enhancer of filamentation 1 (cas-like do 4. 6 453362 H14988 Hs. 107375 ESTs 4. 6 407013 U35637 gb : HumannebulinmRNA, partialcds 4. 6 423757 AL049337 Hs. 132571 Homo sapiens mRNA ; cDNA DKFZp564P016 (fr 4. 6 432363 AA534489 gb : nf76g11. s1 NCl_CGAP_Co3 Homo sapiens 4. 6 408380 AF123050 Hs. 44532 diubiquitin 4. 6 429149 AW193360 Hs. 197962 ESTs, Weakly similar to 138022 hypotheti 4. 6 422170 A1791949 Hs. 112432 anti-Mullerian hormone 4. 6 405558 Target Exon 4. 6 410295 AA741357 Hs. 5174 nidogen (enactin) 4. 6 450166 AA429504 ESTs 4. 6 451418 BE387790 Hs. 26369 hypothetical protein FU20287 4. 5 420075 AF142482 Hs. 203846 TEA domain family member 3 4. 5 422158 L10343 Hs. 112341 proteaseinhibitor3, skin-denved (SKAL 4. 5 457465 AW301344 Hs. 122908 DNA replication factor 4. 5 436827 H72187 Hs. 5322 guanine nudeo6de binding protein (G pr 4. 5 452620 AA436504 Hs. 119286 ESTs 4. 5 424381 AA285249 Hs. 146329 protein kinase Chk2 4. 5 444656 A1277924 Hs. 145199 ESTs 4. 5 450639 A1703186 Hs. 277174 ESTs 4. 5 424247 X14008 Hs. 234734 qsozyme (enai amyioidosis) 4. 5 423178 A1033140 Hs. 124983 HomosapiensmRNA ; cDNA DKFZp564C142 (fr 4. 5 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 4. 5 447444 AK000318 Hs. 18616 hypothetical protein FLJ2031 1 4. 4 401454 NM_014226-: Homosapiensrena'tumoran6 4. 4 420560 AW207748 Hs. 59115 ESTs 4. 4 409205 AI952884 Hs. 14832 ESTs, Moderately similar to unnamed prot 4. 4 451129 BE072881 gb : RC2-BT054&200300-012-e098T0548Homo 4. 4 412530 AA766268 Hs. 266273 hypothetical protein FLJ13346 4. 4 447752 M73700 Hs. 105938 tactotransferrin 4. 4 429083 Y09397 Hs. 227817 BCL2-related protein At 4. 4 418283 S79895 Hs. 83942 cathepsin K (pycnodysostosis) 4. 3 424736 AF230877 Hs. 152701 microtubute-intefacting protein that ass 4. 3 416379 N38857 Hs. 203933 ESTs 4. 3 452994 AW962597 Hs. 31305 KIAA1547 protein 4, 3 437834 AA769294 Hs. 283854 gb : nz36gO3. s1 NCI_CGAP GCB1 Homosapiens 4. 3 441035 A1694309 Hs. 126458 ESTs 4. 3 425292 NM005824 Hs. 155545 37 kDa leucine-rich repeat (LRR) protein 4. 3 418030 BE207573 Hs. 83321 neuromedin B 4. 3 450811 A1739486 Hs. 245497 ESTs 4. 3 438458 AW975186 gb : EST387294 MAGE resequences, MAGN Homo 4. 3 442201 AW516704 Hs. 208726 ESTs 4. 3 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2 doma 4. 3 435677 AA694142 Hs. 293726 ESTs, Weakly similar to TSGA RAT TESTIS 4. 3 442832 AW206560 Hs. 253569 ESTs 4. 3 449318 AW236021 Hs. 78531 Homosapiens, SimilartoRIKENcDNA5730 4. 2 421027 AA761198 Hs. 55254 ESTs 4. 2 414300 A1304870 Hs. 188680 ESTs 4. 2 452874 AK001061 Hs. 30925 hypothetical protein FLJ10199 4. 2 444161 N52543 Hs. 142940 ESTs 4. 2 416908 AA333990 Hs. 80424 coagulation factor XIII, Al polypeptide 4. 2 418483 W26076 Hs. 221847 ESTs 4. 2 443318 A1051603 Hs. 133141 ESTs 4. 2 415079 R43179 Hs. 22895 hypothetical protein FU23548 4. 2 416871 H98716 gb : yx13dO8. s1 Soares melanocyte 2NbHM Ho 4. 2 423678 AW963357 Hs. 7847 ESTs 4. 2 429643 AA455889 Hs. 167279 FYVE-finger-containing Rab5 effector pro 4. 2 438875 AA827640 Hs. 189059 ESTs 4. 2 428600 AW863261 Hs. 242413 hypothetical protein DKFZp434K1421 4. 2 430968 AW972830 gb : EST384925 MAGE resequences, MAGL Homo 4. 2 406872 A1760903 gb : wi09h08. x1 NCl-CGAP-CLL1 Homo sapiens 4. 2 403790 NM001334' : Homo sapiens cathepsin 0 (CTS 4. 1 409112 BE243971 Hs. 50649 quinone oxidoreductase homolog 4. 1 435703 AW630133 Hs. 83313 GK003 protein 4. 1 432625 A1243596 Hs. 94830 ESTs, Moderately similar to T03094 A-kin 4. 1 404407 Target Exon 4. 1 412568 Api878826 Hs. 74034 caveolin1, caveoiaeprotein, 22kD 4. 1 422087 X58968 Hs. 111301 matrixmetalloproteinase2 (gelatinaseA 4. 1 435143 R12375 Hs. 194600 ESTs 4. 1 447497 AW167254 Hs. 205722 ESTs 4. 1 456304 A1820973 gb : nc21cO2. ySNCl_CGAP_Pr1 Homosapiens 4. 1 427676 AA394062 Hs. 300772 tropomyosin 2 (beta) 4. 1 436608 AA628980 down syndrome critical region protein DS 4. 1 453331 A1240665 ESTs 4. 0 420004 AW975532 Hs. 164039 ESTs, Moderately similar to 138022 hypot 4. 0 412125 Y17114 Hs. 73393 eyes absent (Drosophila) homolog 4 4. 0 426215 AW963419 Hs. 155223 stanniocalcin 2 4. 0 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, 4. 0 450581 AF081513 Hs. 25195 TGF-beta 4 4. 0 415323 BE269352 Hs. 949 neutrophil cytosolic factor 2 (65kD, chr 4. 0 409893 AW247090 Hs. 57101 minichromosome maintenance deficient (S. 4. 0

432058 AW665996 Hs. 130729 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 0 444609 AW571659 Hs. 278081 ESTs 4. 0 445666 R59960 Hs. 282386 ESTs 4. 0 437814 A1088192 Hs. 135474 ESTs, WeakiysimilartoDDX9_HUMANATP-D 4. 0 414948 C15240 Hs. 182155 ESTs 4. 0 435542 AA687376 ESTs 4. 0 422564 A1148006 Hs. 222120 ESTs 4. 0 449571 AW016812 Hs. 200266 ESTs 4. 0 433556 W56321 Hs. 111460 calcium/calmodulin-dependent protein kin 4. 0 458946 AA009716 Hs. 42311 ESTs 4. 0 449655 A1021987 Hs. 59970 ESTs 4. 0 426649 A1914936 Hs. 97152 ESTs 4. 0 457292 A1921270 Hs. 281462 hypothetical protein FU14251 4. 0 440435 AL042201 Hs. 21273 transcription factor NYD-splO 4. 0 456977 AK000252 Hs. 169758 hypothetical protein FU20245 4. 0 420649 A1866964 Hs. 124704 ESTs, Moderately similar to S65657 alpha 4. 0 416406 D86961 Hs. 79299 lipoma HMGIC fusion partner-like 2 4. 0 446291 BE397753 Hs. 14623 interferon. gamma-inducible protein 30 3. 9 449256 AA059050 Hs. 59847 ESTs 3. 9 421637 AF035290 Hs. 106300 Homo sapiens clone 23556 mRNA sequence 3. 9 456306 AA225313 Hs. 222886 ESTs, Weakly similar to TRHY_HUMAN TRICH 3. 9 438372 A1140189 Hs. 123191 ESTs 3. 9 427375 AL035460 Hs. 177536 metallocarboxypeptidase CPX-1 3. 9 415131 D61119 gb : HUM158C1 1B Ciontech human fetal brain 3. 9 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 3. 9 424998 U58515 Hs. 154138 chitinase 3-like 2 3. 9 433376 A1249361 Hs. 74122 caspase 4, apptosis-elated cysteine pr 3. 9 455104 BE064863 gb : RC1-BT0313-110300-015-f06BT0313Homo 3. 9 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 3. 9 419594 AA013051 Hs. 91417 topoisomerase (DNA) 11 binding protein 3. 9 417576 AA339449 Hs. 82285 phosphohbosyigiycinamideformyttransfer 3. 9 416857 AA188775 Hs. 292453 ESTs 3. 9 434784 AA649051 Hs. 164007 ESTs 3. 8 438898 A1819863 Hs. 106243 ESTs 3. 8 408102 U46351 Hs. 621 lectin, galactoside-binding, soluble, 3 3. 8 422081 AW136820 Hs. 196011 ESTs 3. 8 411688 AW953440 gb : EST365510 MAGE resequences. MAGB Homo 3. 8 447343 AA256641 Hs. 236894 ESTs, Highly similar to S02392 alpha-2-m 3. 8 406395 Target Exon 3. 8 433675 AW977653 Hs. 75319 ribonuc) reductase M2 polypeptide 3. 8 403696 C4001100' : gil5852342lgbjMD54015. 1l (AFO 3. 8 443740 R56434 Hs. 21062 ESTs 3. 8 413076 U10564 Hs. 75188 wee1 (S. pombe) homolog 3. 8 409189 AA125984 gb : zn27hO6. r1 Stratagene neuroepithelium 3. 8 444326 A1939357 Hs. 270710 ESTs 3. 8 436899 AA764852 Hs. 291567 ESTs 3. 8 445075 A1651827 Hs. 344767 ESTs 3. 8 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 3. 8 429163 AA884766 gb : am20a10. si Soares_NFL_T_GBC_S1 Homos 3. 8 416114 A1695549 Hs. 183868 glucuronidase, beta 3. 8 417018 M16038 Hs. 80887 v-yes-1Yamaguchisarcomaviralelated 3. 8 446839 BE091926 Hs. 16244 mitoUc spindle coiled-coil elated prot 3. 8 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 3. 8 416664 H72780 Hs. 20289 ESTs 3. 8 449444 AW818436 Hs. 23590 solute carrier family 16 (monocarboxylic 3. 8 419735 AW750056 Hs. 169577 Homo sapiens cDNA FW 14743 hs, clone NT 3. 8 448275 BE514434 Hs. 20830 kinesin-like 2 3. 7 405141 Y14443 zinc finger protein 200 3. 7 411537 BE073250 gb : MRO-BT0551-060300-102-eO5 BT0551 Homo 3. 7 422648 D86983 Hs. 118893 Melanoma associated gene 3. 7 449145 A1632122 Hs. 198408 ESTs 3. 7 428060 AA420616 Hs. 249483 ESTs 3. 7 404584 Target Exon 3. 7 418596 AW976721 Hs. 293327 ESTs 3. 7 458072 A1890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 3. 7 445908 R13580 Hs. 13436 Homo sapiens clone 24425 mRNA sequence 3. 7 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 3. 7 431770 BE221880 Hs. 268555 5-3'exoribonuclease 2 3. 7 427809 M26380 Hs. 180878 lipoprotein lipase 3. 7 436674 AA725002 Hs. 272018 low molecular mass ubiquinone-binding pr 3. 7 413450 Z99716 Hs. 75372 N-acetylgalactosaminidase, alpha-3. 7 434467 BE552368 Hs. 231853 Homo sapiens cDNA FLJ 13445 fis, clone PL 3. 7 448048 BE281291 Hs. 170408 ESTs, Moderately similar to A47582 B-cel 3. 7 422798 R92347 Hs. 34574 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 7 402082 C18000743* : gii66783631reqNP-033416. 11 t 3. 7 448019 AW947164 Hs. 195641 ESTs, Moderately similar to 138022 hypot 3. 7 428873 A1701609 Hs. 98908 ESTs 3. 7 437323 AA371145 Hs. 194397 teptin receptor 3. 7 413095 AA494359 Hs. 30715 potassium vottage-gated channel, Isk-rel 3. 7 425139 AW630488 Hs. 25338 protease, serine, 23 3. 7 452279 AA286844 Hs. 61260 hypothetical protein FLJ13164 3. 7 439574 A1469788 Hs. 165190 ESTs 3. 7 408829 NM_006042 Hs. 48384 heparan sulfate (glucosamine) 3-0-sulfot 3. 7

407838 BE146411 Hs. 40342 putative nuclear protein 3. 7 437748 AF234882 Hs. 5814 suppression of tumorigenicity 7 3. 6 437470 AL390147 Hs. 134742 hypothe6cal protein DKFZp5470065 3. 6 400288 X06256 Hs. 149609 integrin, alpha 5 (fibronectin receptor. 3. 6 453438 A1469935 Hs. 22792 ESTs 3. 6 415024 A1983981 Hs. 189114 ESTs 3. 6 419713 AW968058 Hs. 92381 nudix (nucleosidediphosphatelinkedmoi 3. 6 441523 AW514263 Hs. 301771 ESTs, WeaklysimilartoALUF HUMAN ! ! ! ! 3. 6 416427 BE244050 Hs. 79307 RaclCdc42 guanine exchangefactor (GEF) 3. 6 448002 Y15227 Hs. 20149 deleted in lymphocytic leukemia, 1 3. 6 441362 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re 3. 6 456534 X91195 Hs. 100623 phospholipase C, beta 3, neighbor pseudo 3. 6 402239 Target Exon 3. 6 450297 AW901347 Hs. 38592 hypothetical protein FLJ23342 3. 6 443715 A1583187 Hs. 9700 cyclin E1 3. 6 403011 ENSP00000215330' : Pnobable senne/threoni 3. 6 428403 Api393048 Hs. 326159 leucine rich repeat (in FLIl) interac6n 3. 6 425202 AW962282 Hs. 152049 ESTs, Weakly similar to 138022 hypotheb 3. 6 409557 BE182896 Hs. 211193 ESTs 3. 6 453948 A1970797 Hs. 64859 ESTs 3. 6 440225 BE295782 Hs. 159 tumor necrosis factor receptor superfami 3. 6 425331 AW962128 gb : EST374201 MAGE resequences, MAGG Homo 3. 6 442326 H92962 Hs. 124813 hypothetical protein MGC14817 3. 6 437640 AA764893 Hs. 272155 ESTs, Weakly similar to 138022 hypotheti 3. 6 424051 AL110203 Hs. 138411 HomosapiensmRNA, cDNADKFZp586J1922 (f 3. 6 406481 Target Exon 3. 6 433835 A1806185 gb : wf26a10. x1SoaresNFLTGBCS1 Homos 3. 6 456052 BE311901 Hs. 28935 gb : 601142614F1 NlH_MGC_14Homosapiensc 3. 6 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 3. 5 439726 AW449893 Hs. 293707 ESTs, Weakly similar to 138598 zinc ting 3. 5 416913 AW934714 gb : RC1-DT0001-031299-011-a11 DT0001 Homo 3. 5 419402 Z68155 Hs. 90291 laminin, beta 2 (laminin S) 3. 5 403108 ENSPOO000241415* : Hypothetical 67. 7 kDa p 3. 5 426509 M31166 Hs. 2050 pentaxin-related gene, rapidly induced b 3. 5 418883 BE387036 Hs. 1211 acid phosphatase 5, tartrate resistant 3. 5 432188 A1362952 Hs. 2928 solute carder family 7 (cationic amino 3. 5 448789 BE539108 Hs. 22051 hypotheticalprotein MGC15548 3. 5 427299 AA830210 Hs. 214263 ESTs, Moderately similar to ALU1HUMAN A 3. 5 425212 AW962253 Hs. 171618 ESTs 3. 5 422938 NM_001809 Hs. 1594 centromere protein A (17kD) 3. 5 442264 A1278777 Hs. 263455 ESTs, Weakly similar to ALU1HUMANALUS 3. 5 407253 AA411175 Hs. 141939 ESTs, Moderately similar to S65657 alpha 3. 5 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 3. 5 452682 AA456193 Hs. 9071 progesterone membrane binding protein 3. 5 421247 BE391727 Hs. 102910 general transcripGon factor IIH, polype 3. 5 418049 AA211467 Hs. 190488 Homo sapiens, Similar to nuclear localiz 3. 5 453792 AL134539 Hs. 254129 KIAA1678 3. 5 416426 AA180256 Hs. 210473 Homo sapiens cDNA FW14872 hs clone PL 3. 5 412014 A1620650 Hs. 43761 ESTs, Weakly similar to A46010 X-linked 3. 5 440370 AA884000 Hs. 8173 hypothetical protein FU10803 3. 5 407729 T40707 Hs. 270862 ESTs 3. 5 438527 A1969251 Hs. 115325 RAB7, member RAS oncogene family-like 1 3. 5 455646 BE064420 gb : RC4-BT0311-241199-012-cO8BT0311 Homo 3. 5 418630 A1351311 Hs. 251946 poly (A)-binding protein, cytoplasmic 1-1 3. 5 432242 AW022715 Hs. 162160 ESTs, Weakly similar to ALU4_HUMAN ALU S 3. 5 424503 NM 002205 Hs. 149609 integrin, alpha 5 (fibfonectin receptor. 3. 4 449932 A1675444 Hs. 263024 ESTs 3. 4 427700 AA262294 Hs. 180383 dual specificity phosphatase 6 3. 4 403849 Target Exon 3. 4 429747 M87507 Hs. 2490 caspase 1, apoptosis-related cysteine pr 3. 4 451446 A1826288 Hs. 171637 hypothetical protein MGC2628 3. 4 434589 AF147363 gb : Homo sapiens full length insert cDNA 3. 4 403361 NM002210* : Homo sapiens integrin, alpha 3. 4 420841 A1625251 Hs. 94037 hypothetical protein FLJ23053 3. 4 438206 AA780385 Hs. 187885 ESTs 3. 4 425295 AA431366 Hs. 37251 ESTs 3. 4 411789 AF245505 Hs. 72157 Adlican 3. 4 440948 AW188311 Hs. 128619 ESTs 3. 4 439518 W76326 gb : zd60dO4. r1 Soaes_fetal_heart_NbHH19W 3. 4 418821 AA436002 Hs. 183161 ESTs 3. 4 459660 M79082 ESTs 3. 4 404209 Target Exon 3. 4 443950 NM 001425 Hs. 9999 epithelial membrane protein 3 3. 4 430694 AA810624 Hs. 30936 ESTs, WeaklysimilartoH2BH_HUMANHIST0 3. 4 425300 AW601773 Hs. 270259 ESTs 3. 4 420300 AA258245 Hs. 127573 HomosapiensFKSG41 (FKSG41} mRNA, compl 3. 4 458438 A1141520 Hs. 151464 ESTs, Weakly similar to ALUC_HUMAN ! ! ! ! 3. 4 444911 U06117 Hs. 250 xanthene dehydrogenase 3. 4 421064 AI245432 Hs. 101382 tumor necrosis factor, alpha-induced pro 3. 4 441287 AW293132 Hs. 131373 ESTs 3. 4 446960 AW294936 Hs. 156762 ESTs 3. 4 405605 C2001342 : gil127814lsplP26434lNAH4_RAT SO 3. 4 433791 AA719352 Hs. 112718 ESTs 3. 4

405238 Target Exon 3. 4 412986 X81120 Hs. 75110 cannabinoidreceptort (brain) 3. 4 414372 AA143654 gb : zo65aO2. r1Stratagene pancreas (93720 3. 4 435523 T62849 Hs. 11090 membrane-spanning4-domåns, subfamilyA 3. 4 406739 Al566709 Hs. 182426 ribosome protein S2 3. 4 442710 A1015631 Hs. 23210 ESTs 3. 4 452526 W38537 Hs. 280740 hypothetical protein MGC3040 3. 4 456060 C14904 Hs. 45184 Homo sapiens cDNA FLJ12284 fis, clone MA 3. 4 435005 U80743 Hs. 306094 tinudeotide repeat containing 12 3. 4 421674 T10707 Hs. 296355 hypothetical protein FLJ23138 3. 4 425242 D13635 Hs. 155287 KIAA0010 gene product 3. 4 436805 AA731533 Hs. 270751 ESTs 3. 4 418641 BE243136 Hs. 86947 a disintegrin and metalioproteinase doma 3. 4 430809 Api791150 Hs. 262009 ESTs, Moderately similar to 138022 hypot 3. 4 428878 AA436884 Hs. 48926 ESTs 3. 3 413774 AA131782 Hs. 182314 ESTs 3. 3 400533 ENSP00000209376' : PRED65 protein (Fragmen 3. 3 422448 AW372922 Hs. 116774 integrin, alpha 1 3. 3 423905 AW579960 Hs. 135150 lungqpe-lcellmembrane-associatedgly 3. 3 430637 BE160081 Hs. 256290 S100calcium-binding protein A11 (calgiz 3. 3 427899 AA829286 Hs. 332053 serum amyloid At 3. 3 434206 AW136973 Hs. 180479 ESTs. Weakly similar to S69890 mitogen i 3. 3 453387 A1990741 Hs. 252809 ESTs 3. 3 436265 AA731331 Hs. 190668 ESTs 3. 3 412971 AA889628 Hs. 35125 ESTs 3. 3 441701 AW339828 Hs. 127497 ESTs 3. 3 418967 NM 001725 Hs. 89535 bætericida/pemmeabiliq-increasingpro 3. 3 434577 R37316 Hs. 179769 Homo sapiens cDNA : FLJ22487 fis, clone H 3. 3 418216 AA662240 Hs. 283099 AF15q14 protein 3. 3 436137 Ait56769 Hs. 133512 ESTs 3. 3 428715 AW293716 Hs. 53126 ESTs 3. 3 449249 T52285 Hs. 193115 Homo sapiens mRNA for KIM1764 protein, 3. 3 440074 AA863045 Hs. 10669 ESTs, Weakly similar to T00050 hypthe6 3. 3 405046 C3000978 : gil9280045ldbiBABO1579. 1l (ABO 3. 3 437816 Al823445 Hs. 280699 ESTs 3. 3 401272 C9000559* : gil 1 2314195lembiCAB99338. 11 (A 3. 3 408896 A1610447 Hs. 48778 niban protein 3. 3 432343 NM002960 Hs. 2961 S100 calcium-binding protein A3 3. 3 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-0-sulfot 3. 3 439978 BE139460 Hs. 124673 HomosapienscDNAFW11477hs, cloneHE 3. 3 421094 AW978202 Hs. 289064 hypothetical protein FU22251 3. 3 428722 U76456 Hs. 190787 tissue inhibitor of metalloproteinase 4 3. 3 446134 AW161234 Hs. 13993 TBP-like 1 3. 3 412281 A1810054 Hs. 14119 ESTs 3. 3 436282 R91913 Hs. 272104 ESTs, ModeratelysimilartoALU1_HUMANA 3. 3 452203 X57522 transprter 1, ATP-binding cassette, sub 3. 3 421307 BE539976 Hs. 103305 Homo sapiens mRNA ; cDNADKFZp434B0425 (f 3. 3 409463 A1458165 Hs. 17296 hypothetical protein MGC2376 3. 3 411565 AW851728 gb : MR2-CT0222-011199-007-dO6 CT0222 Homo 3. 3 410422 AL042014 Hs. 63348 Homo sapiens, clone MGC : 15203, mRNA, com 3. 3 450506 NM004460 fibrobtastactivaton protein, alpha 3. 3 451254 A1571016 Hs. 172967 ESTs 3. 3 423784 AK000039 Hs. 132826 Homo sapiens CDNA FU 14913 fis, clone PL 3. 3 433325 AW206986 Hs. 143905 ESTs 3. 3 419896 Z99362 gb : HSZ99362DKFZphamy1HomosapienscDNA 3. 3 420552 AK000492 Hs. 98806 hypothetical protein 3. 3 451778 A1826131 Hs. 62954 ESTs, Weakly similar to zinc finger prot 3. 3 427584 BE410293 Hs. 179718 v-myb avian myeloblastosis viral oncogen 3. 2 433507 A1817336 Hs. 191791 ESTs 3. 2 418661 NM 001949 Hs. 1189 E2F transcription factor3 3. 2 440933 Api208217 Hs. 142879 ESTs 3. 2 426746 J03626 Hs. 2057 uridine monophosphate synthetase (orotat 3. 2 404120 C5000537* : gil32985951gblAAC41376. 11 (AFO 3. 2 453920 Api133148 Hs. 36602 I factor (complement) 3. 2 437014 AA808757 Hs. 222531 ESTs, Weakly similar to S59501 interfere 3. 2 424479 AF064238 Hs. 149098 smoothelin 3. 2 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa 3. 2 425922 AL157466 Hs. 162751 Homo sapiens mRNA ; cDNA DKFZp761E2423 (f 3. 2 407304 AA565832 Hs. 271649 gb : nj32bO3. s1 NCI_CGAP_M1 Homosapiens 3. 2 411671 BE049094 ESTs 3. 2 420352 BE258835 gb : 601117374F1 NlH_MGC_16Homosapiensc 3. 2 454765 AW819629 gb : RC5-ST0293-140200-014-H05 ST0293 Homo 3. 2 410407 X66839 Hs. 63287 carbonic anhydrase IX 3. 2 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 3. 2 434563 AW083994 Hs. 9469 pleckstrin homology domain-containing, f 3. 2 417124 BE122762 Hs. 25338 ESTs 3. 2 407378 AA299264 Hs. 57776 ESTs, Moderately similar to 138022 hypot 3. 2 439764 T26535 Hs. 22744 hypothetical protein MGC13105 3. 2 445936 BE543594 Hs. 61478 hypothetical protein FU22329 3. 2 446523 NM_003063 Hs. 334629 sarcolipin 3. 2 406060 Target Exon 3. 2 432250 AA452088 Hs. 274170 Opa-interac6ng protein 2 3. 2 437269 AA334384 Hs. 149420 ESTs 3. 2

449115 AW959952 Hs. 37528 ESTs, Weakly similar to AF090944 1 PR006 3. 2 425146 AW954627 gb : EST366697 MAGE resequences, MAGC Homo 3. 2 436210 A1825420 Hs. 197824 ESTs 3. 2 437698 R61837 Hs. 7990 ESTs, Moderately similar to 184505 calci 3. 2 444371 BE540274 Hs. 239 forkhead box M1 3. 2 410006 AW732308 Hs. 57783 eukaryotic translation initiation factor 3. 2 445828 F05802 Hs. 81907 ESTs 3. 2 450810 BE207588 Hs. 334360 transforming growth factor beta 1 induce 3. 2 439533 W76021 gb : zd64cO4. r1Soaresfeta) heartNbHH19W 3. 2 418079 R40058 Hs. 6911 ESTs 3. 2 418781 T41160 Hs. 8404 ESTs 3. 2 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur 3. 2 431319 AA873350 Hs. 302232 ESTs 3. 2 445413 AA151342 Hs. 12677 CGI-147 protein 3. 2 424947 R77952 ESTs, Weakly similar to alternatively sp 3. 2 429490 A1971131 Hs. 23889 ESTs, Weakly similar to ALU7_HUMAN ALU S 3. 2 426765 AA743603 Hs. 172108 nucleoporin 88kD 3. 2 419726 U50330 Hs. 1274 bone morphogene6c protein 1 3. 2 425849 AJ000512 Hs. 296323 serum/glucocorticoid regulated kinase 3. 1 439566 AF086387 gb : Homo sapiens full length insert cDNA 3. 1 452574 AF127481 Hs. 301946 lymphoid blast crisis oncogene 3. 1 439753 BE262233 Hs. 7423 hypothetical protein from EUROIMAGE 2168 3. 1 435256 AF193766 Hs. 13872 cytokine-like protein C17 3. 1 439570 T79925 Hs. 269165 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 1 443431 A1056847 Hs. 20654 ESTs 3. 1 428289 M26301 Hs. 2253 complement component 2 3. 1 415849 R20529 Hs. 6806 ESTs 3. 1 419652 AL157485 Hs. 91973 hypothetical protein 3. 1 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactin) 3. 1 457579 AB030816 Hs. 36761 HRAS-like suppressor 3. 1 420579 AA278449 Hs. 137429 ESTs 3. 1 408116 AA251393 Hs. 289052 Homosapiens, SimilartoRIKENcDNA5430 3. 1 408247 AA053451 Hs. 225632 leucine zipper protein 3 3. 1 405183 NM_016358-: Homosapiensinquoishomeobo 3. 1 420676 Ai434780 Hs. 4248 vav 2 oncogene 3. 1 440286 U29589 Hs. 7138 cholinergic receptor, muscarinic 3 3. 1 431176 A1026984 Hs. 293662 ESTs 3. 1 417918 AA209205 Hs. 163754 hypotheUca'protein FW12606 3. 1 437945 T78519 gb : yd68cO8. r1 Soares fetal liver spleen 3. 1 404632 NM_022490 : Homo sapiens hypothetical prot 3. 1 428917 AA437337 Hs. 16689 ESTs 3. 1 429940 W25215 gb : zb87aO9. r1 Soares_senescent_fibroblas 3. 1 444016 AA448154 gb : zw82hO9. r1 Soares testis_NHT Homo sap 3. 1 430701 A1760833 Hs. 293971 ESTs 3. 1 402229 BE262804 mitochondrial dbosomal protein S2 3. 1 454177 AW807321 gb : MR4-ST0062-240300-003-gO5 ST0062 Homo 3. 1 400090 Eos Control 3. 1 419326 W94915 Hs. 42419 ESTs 3. 1 435644 AA700867 Hs. 269659 ESTs 3. 1 433042 AW193534 Hs. 281895 Homo sapiens cDNA FLJ 11660 fis, clone HE 3. 1 458810 BE407125 Hs. 231510 ESTs 3. 1 414403 AW969551 Hs. 76064 dbosomal protein L27a 3. 1 449670 F07693 Hs. 85603 Homo sapiens mRNA ; cDNA DKFZp434K2172 (f 3. 1 403288 C1001737-: gil7511201lpirllT27904hypothe 3. 1 430535 AW968485 gb : EST380561 MAGE resequences, MAGJ Homo 3. 1 455899 BE155112 gb : PM1-HT0350-151299-003-a03HT0350Homo 3. 1 432044 AW972727 gb : EST384819 MAGE resequences, MAGL Homo 3. 1 443105 X96753 Hs. 9004 chondroiUn sulfate proteoglycan 4 (mela 3. 1 423789 AK002084 Hs. 132851 hypthetica protein FW11222 3. 1 439538 AA837323 Hs. 56407 ESTs 3. 1 437681 A1207958 Hs. 166556 Homo sapiens, Similar to TEA domain fami 3. 1 433577 AW007080 Hs. 284192 ESTs 3. 1 443021 AA368546 Hs. 8904 Ig superfamily protein 3. 1 433894 A1907682 Hs. 243293 ESTs 3. 1 414884 R54418 Hs. 183745 hypotheticalprotein FU13456 3. 1 408996 A1979168 Hs. 344096 glycoprotein (transmembrane) nmb 3. 1 449162 A1632740 Hs. 10476 ESTs 3. 1 417893 AA290605 Hs. 190002 ESTs 3. 1 433578 BE336886 Hs. 3416 adipose differenbabon-related protein 3. 0 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 3. 0 450756 A1733488 Hs. 144062 ESTs 3. 0 422631 BE218919 Hs. 118793 hypothetical protein FLJ10688 3. 0 414733 BE514535 Hs. 77171 minichromosome maintenance deficient (S. 3. 0 431019 NM005249 Hs. 2714 forkheæd box G1B 3 0 434503 T96231 Hs. 17762 ESTs 3. 0 455481 AW948317 gb : RCO-MT0015-280300-021-aO9 MT0015 Homo 3. 0 427413 BE547647 Hs. 177781 hypothetical protein MGC5618 3. 0 414396 BE548266 Hs. 76057 galactose-4-epimerase, UDP-3. 0 458760 A1498631 Hs. 111334 ferritin. tight poiypeptide 3. 0 410555 U92649 Hs. 64311 adisintegnnandmeta'loproleinasedoma 3. 0 411543 AW851248 gb : IL3-CT0220-160200-066-F01 CT0220 Homo 3. 0 435375 A1733610 Hs. 187832 ESTs 3. 0 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 3. 0

432065 AA401039 Hs. 2903 protein phosphatase 4 (formerly X), cata 3. 0 443338 R99575 Hs. 302908 ESTs 3. 0 433062 AK001757 Hs. 281348 hypothetical protein FW10895 3. 0 412135 AW895309 gb : QV4-NN0038-300300-155-e07NN0038Homo 3. 0 418669 U85992 Hs. 87197 Human clone IMAGE : 35527 unknown protein 3. 0 449385 A1650471 Hs. 347290 ESTs 3. 0 426384 A1472078 Hs. 303662 hypothe6cal protein FLJ13189 (FLJ13189) 3. 0 436267 AW450938 Hs. 180115 ESTs 3. 0 440388 A1693520 Hs. 223000 ESTs 3. 0 427235 At126288 Hs. 192232 ESTs 3. 0 420116 NM 013241 Hs. 95231 FH1/FH2 domain-containing protein 3. 0 419764 BE262524 Hs. 93183 vasodilator-sbmulated phosphoprotein 3. 0 406673 M34996 Hs. 198253 major histocompatibility complex, class 3. 0 445921 AW015211 Hs. 146181 ESTs 3. 0 427695 R88483 Hs. 172862 ESTs 3. 0 453324 W26592 Hs. 232089 ESTs 3. 0 404272 Target Exon 3. 0 428538 AA446440 Hs. 98643 ESTs 3. 0 442786 H50733 Hs. 256261 ESTs, Moderately similar to ALU8_HUMAN A 3. 0 444396 T65213 Hs. 4257 ESTs 3. 0 440483 A1200836 Hs. 150386 ESTs 3. 0 429973 A) 423317 Hs. 164680 ESTs 3. 0 450125 AA005418 Hs. 158186 ESTs 3. 0 417409 BE272506 Hs. 82109 syndecan 1 3. 0 429569 AA454993 Hs. 138343 ESTs, Weakly similar to 178885 sednetth 3. 0 455778 BE088746 gb : CM2-BT0693-210300-123-dO9 BT0693 Homo 3. 0 427954 J03060 Hs. 247551 metaxin 1 3. 0 422418 AK001383 Hs. 116385 hypothefical protein FU 10521 3. 0 427527 A1809057 Hs. 293441 immunoglobulin heavy constant mu 3. 0 416677 T83470 Hs. 334840 ESTs, Moderately similar to 178885 serin 3. 0 451130 A1762250 Hs. 345554 ESTs 3. 0 431431 AL096711 Hs. 252953 HumanDNAsequenaefromcloneRP3-403A15 3. 0 425248 AW957442 Hs. 252766 ESTs 3. 0 422757 A1909935 Hs. 65551 Homo sapiens, Similar to DNA segment, Ch 3. 0 431836 AF178532 Hs. 271411 beta-site APP-cleaving enzyme 2 3. 0 416355 H49875 Hs. 268906 ESTs 3. 0 426406 Api742501 Hs. 169756 complement component 1, s subcomponent 3. 0 419829 AI924228 Hs. 115185 ESTs, Moderately similar to PC4259 ferti 3. 0 412646 NM 006825 Hs. 74368 transmembrane protein (63kD), endoplasmi 2. 9 423869 BE409301 Hs. 134012 Ciq-relatedfactor 2. 9 422710 AW936566 Hs. 201876 ESTs 2. 9 445906 N28939 Hs. 13434 Homo sapiens clone 24418 mRNA sequence 2. 9 429751 M55210 Hs. 214982 laminin, gamma 1 (formerly LAMB2) 2. 9 430413 AW842182 Hs. 241392 small inducible cytokine A5 (RANTES) 2. 9 443433 R44743 Hs. 301667 ESTs 2. 9 444145 BE153823 Hs. 282385 ESTs, Weakly similar to 2004399A chromos 2. 9 425262 D87119 Hs. 155418 GS3955 protein 2. 9 442476 AF069475 gb : AF069475 Homo sapiens astrocytoma lib 2. 9 443361 Api792628 Hs. 133273 ESTs 2. 9 427144 X95097 Hs. 2126 vasoactive intestinal peptide receptor 2 2. 9 415709 AA649850 Hs. 278558 ESTs 2. 9 453385 AW296101 Hs. 252806 ESTs 2. 9 442609 AL020996 Hs. 8518 selenoprotein N 2. 9 443378 AW392550 Hs. 9280 proteasome (prosome, macropain) subunit 2. 9 414416 AW409985 Hs. 76084 hypothetical protein MGC2721 2. 9 443502 A1074528 Hs. 133949 ESTs 2. 9 444143 AW747996 Hs. 160999 ESTs, Moderately similar to A56194 throm 2. 9 416308 AW291942 Hs. 23628 3 beta-hydroxy-delta §C27-steroid oxido 2. 9 447674 BE270640 Hs. 19192 cyclin-dependent kinase 2 2. 9 408989 AW361666 Hs. 49500 KIAA0746 protein 2. 9 427418 AA402587 Hs. 325520 LAT1-3TM protein 2. 9 408788 AL134947 Hs. 213956 Homo sapiensBAC clone RP11-10205 from Y 2. 9 426827 AW067805 Hs. 172665 methylenetetrahydrofolatedehydrogenase 2. 9 403290 C10001011' : gi4758212MNP004411. 1 ! d 2. 9 430890 X54232 Hs. 2699 glypican 1 2. 9 441217 A1922183 Hs. 213246 ESTs 2. 9 418287 Al872319 Hs. 78935 methionine aminopeptidase ; eIF-2-associa 2. 9 443836 BE221613 Hs. 140553 ESTs 2. 9 451527 AF022813 Hs. 26518 transmembrane 4 superfamily member 7 2. 9 418110 R43523 Hs. 217754 hypotheUca'proteinFW22202 2. 9 420886 AA805453 ESTs, Weakly similar to T29012 hypotheti 2. 9 439379 AA835002 Hs. 125611 ESTs 2. 9 426197 AA004410 Hs. 100009 acyl-Coenzyme A oxidase 1, palmitoyl 2. 9 406679 AA070786 gb : zm66bO7. r1 Stratagene neuroepithelium 2. 9 454120 AB032990 Hs. 40719 hypothetical protein KIAA1164 2. 9 457244 AA581385 Hs. 162473 ESTs, Weakly similar to 138022 hypothe6 2. 9 432036 AF224266 Hs. 272373 intedeukin 20 2. 9 457364 AW971037 gb : EST383123 MAGE resequences, MAGK Homo 2. 9 437860 AA333063 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 2. 9 453544 AA831785 Hs. 171914 Homo sapiens cDNA FU14209 fis, clone NT 2. 9 454968 AW849046 gb : L3-CT0214. CT0214 Homo 2. 9 437528 N59646 Hs. 169745 crumbs (Drosophila) homolog 1 2. 9 400850 Target Exon 2. 9

428896 AW291932 Hs. 98936 ESTs 2. 9 426140 AF131798 Hs. 343768 Homo sapiens clone 25119 mRNA sequence 2. 9 408872 A1476139 Hs. 13291 ESTs 2. 9 414799 Axa52416 Hs. 77326 insulin-like growth factor binding prote 2. 9 406646 M33600 Hs. 308026 major histocompatibility complex, class 2. 9 416569 H64891 gb : yr68h03. r1Soaresfetalliverspleen 2. 9 439130 AA306090 Hs. 124707 ESTs 2. 9 451433 AA021140 Hs. 269265 ESTs, Weakly similar to A46010 X-linked 2. 9 430314 AA369601 Hs. 239138 pe-B-cellcolony-enhancingfætor 2. 9 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 2. 9 420172 AA601122 Hs. 95655 secreted and transmembrane 1 2. 9 442485 BE092285 Hs. 29724 hypotheticalprotein FU13187 2. 9 416505 H66470 Hs. 16004 ESTs 2. 9 415198 AW009480 Hs. 943 natural killer cell transcript 4 2. 9 420674 NM 000055 Hs. 1327 butyrylcholinesterase 2. 9 452139 Axa099969 Hs. 16331 Homo sapiens cDNA : FLJ21482 fis, clone C 2. 8 447499 AW262580 Hs. 147674 protocadhenn beta 16 2. 8 411373 BE326276 Hs. 8861 ESTs 2. 8 456816 AK001509 Hs. 144391 hypothetical protein FW10647 2. 8 414232 W86946 Hs. 238246 hypothetical protein FLJ22479 2. 8 416188 BE157260 Hs. 79070 v-myc avian myelocytomatosis viral oncog 2. 8 447733 AF157482 Hs. 19400 MAD2 (mitotic arrest deficient, yeast, h 2. 8 438624 AA889055 Hs. 123468 ESTs 2. 8 452102 U04343 Hs. 27954 CD86 antigen (CD28 antigen ligand 2, 87-2. 8 408716 A1567839 Hs. 151714 Homo sapiens mRNA fo KIAA1769 protein, 2. 8 424028 AF055084 Hs. 153692 Homo sapiens cDNA FW14354 hs, done Y7 2. 8 421679 A1475110 Hs. 203933 ESTs 2. 8 450651 W79000 Hs. 44545 ESTs, Weakly similar to B34087 hypotheti 2. 8 452785 AL359942 Hs. 296434 erythroid differentiation and denucleati 2. 8 432842 AW674093 Hs. 334822 hypothetical protein MGC4485 2. 8 403291 Target Exon 2. 8 453096 AW294631 Hs. 11325 ESTs 2. 8 422545 X02761 Hs. 287820 hbnonecUn 1 2. 8 440296 D30829 Hs. 180610 splicing factor proline/glutamine rich 2. 8 427154 AL137262 Hs. 325630 hypothetical protein MGC4289 2. 8 422282 AF019225 Hs. 114309 apolipoprotein L 2. 8 434868 R50032 Hs. 159263 collagen, qpeVl, alpha2 2. 8 414727 BE466904 Hs. 190162 gb : hz28fO3. x1 NCI_CGAP_GC6 Homo sapiens 2. 8 437437 AA226869 hypothetical protein DKFZp762L0311 2. 8 427722 AK000123 Hs. 180479 hypothetical protein FU20116 2. 8 443623 AA345519 Hs. 9641 complementcomponent1, qsubcompnent, 2. 8 444006 BE395085 Hs. 10086 type I transmembrane protein Fn14 2. 8 448432 A1783586 Hs. 208575 ESTs 2. 8 453682 T79703 gb : yd71eO8. r1 Soares fetal liver spleen 2. 8 447527 A1702896 Hs. 42091 ESTs 2. 8 418557 BE140602 Hs. 246645 ESTs 2. 8 409157 AA064631 gb : zf72c03. s1 Soares pineal_gland_N3HPG 2. 8 457653 A1820719 Hs. 154662 DnaJ (Hsp40) homolog, subfamily A, membe 2. 8 456908 A1953671 Hs. 220994 hypothetical protein FU14129 2. 8 439220 AW295340 Hs. 130417 ESTs, Weakly similar to Z195_HUMAN ZINC 2. 8 418312 AW972468 Hs. 170307 Rai guanine nucleotide exchange factor R 2. 8 , 454581 AW809189 gb : MR4-ST0118-261099-012-e10ST0118Homo 2. 8 419169 AW851980 Hs. 262346 ESTs, Weakly similar to S72482 hypotheti 2. 8 400645 Target Exon 2. 8 413951 AW051200 Hs. 75640 natriureticpeptide precursor A 2. 8 441360 A1091713 Hs. 106597 Homo sapiens, Similar to RIKEN cDNA 1110 2. 8 404150 Target Exon 2. 8 402936 ENSP00000217246' : DJ803K15. 1 (novel prote 2. 8 454457 AW753456 gb : QV2-CT0261-261099-011-d11 CT0261 Homo 2. 8 439544 W26354 Hs. 28891 hyptheticaproteinFLJ11360 ; anemisp 2. 8 403969 ENSP00000034663 : Zinc finger protein 131 2. 8 447183 A1554733 Hs. 173182 ESTs 2. 8 446566 H95741 Hs. 17914 membrane-spanning 4-domains, subfamily A 2. 8 426141 C05886 Hs. 293972 ESTs 2. 8 440146 AW014231 Hs. 90790 Homo sapiens cDNA : FU22930 fis, clone K 2. 8 430335 D80007 Hs. 239499 KIAA0185 protein 2. 8 447071 AW236867 Hs. 244376 ESTs 2. 8 428899 AA744610 Hs. 194431 paladin 2. 8 400658 ENSP00000237081' : KIAA1217 PROTEIN (FRAGM 2. 8 403942 Target Exon 2. 8 420565 A1806770 Hs. 30258 ESTs 2. 8 409734 BE161664 Hs. 56155 hypothetical protein 2. 8 456645 AF227156 Hs. 110103 RNA polymerase I transcription factor RR 2. 8 401841 NM015113 : Homo sapiens KIAA0399 protein 2. 8 447247 AW369351 Hs. 287955 Homo sapiens CDNA FU 13090 fis, clone NT 2. 8 450150 A1754391 Hs. 23510 Kruppel-likefætor12 2. 8 409154 U72882 Hs. 50842 interferon-induced protein 35 2. 8 410267 AW978005 Hs. 12600 N-ethylmaleimide-sensitivefætorattæh 2. 8 448224 R48700 Hs. 20733 Homo sapiens cDNA : FLJ22356 fis, clone H 2. 8 410268 AA316181 Hs. 61635 six transmembrane epithelial antigen of 2. 8 447512 AW958148 Hs. 129454 ESTs 2. 8 417749 U09196 Hs. 82520 polymerase (DNA-directed), delta 4 2. 8 415293 R49462 Hs. 106541 ESTs 2. 8

416207 NM 014745 Hs. 79077 Homo sapiens, clone MGC : 2908, mRNA, comp 2. 8 423337 NM 004655 Hs. 127337 axin 2 (conductin, axil) 2. 8 425128 BE561929 Hs. 154718 tumorproteinD52-like2 2. 7 444491 A1151091 Hs. 270714 ESTs 2. 7 428311 NM 005651 Hs. 183671 tryptophan 2, 3-dioxygenase 2. 7 430377 NM 001922 Hs. 301865 dopachrome tautomerase (dopachrome delta 2. 7 417944 AU077196 Hs. 82985 collagen, type V, alpha 2 2. 7 444153 AK001610 Hs. 10414 hypotheUca'proteinFW10748 2. 7 438138 R98299 Hs. 177502 ESTs 2. 7 425421 L11669 Hs. 157145 tetracycline transporter-like protein 2. 7 431070 AW408164 Hs. 249184 transcription factor 19 (SC1) 2. 7 451748 AK001612 Hs. 26962 Homo sapiens cDNA FW 10750 hs, clone NT 2. 7 452085 AW239140 Hs. 25614 ESTs. Weakly similar to PC4396 mucin 3 T 27 405941 Target Exon 2. 7 417395 BE564245 Hs. 82084 integrin beta 3 binding protein (beta3-e 2. 7 449667 AB023227 Hs. 23860 KIAA1010 protein 2. 7 428808 AA436007 Hs. 188780 ESTs 2. 7 425843 BE313280 Hs. 159627 death associated protein 3 2. 7 438025 AW501360 Hs. 258910 ESTs 2. 7 400924 Target Exon 2. 7 412898 Api129903 Hs. 74669 vesicle-associated membrane protein 5 (m 2. 7 413834 BE296896 Hs. 224179 ESTs. Weakly similar to 138022 hyptheti 2. 7 453785 A1368236 Hs. 283732 ESTs, Moderately similar to ALU1 HUMAN A 2. 7 406736 A1254733 Hs. 182426 ribosoma protein S2 2. 7 414280 BE410769 Hs. 75873 zyxin 2. 7 434203 BE262677 Hs. 283558 hypothetical protein PR01855 2. 7 442621 Al004333 Hs. 130553 ESTs, Weakly simitar to ALUAHUMAN ! ! ! ! 2. 7 414591 Api888490 Hs. 55902 ESTs, Weakly similar to ALU8_HUMAN ALU S 2. 7 416547 H62914 Hs. 268946 ESTs, Weakly similar to PC4259 ferritin 2. 7 416784 AA334592 Hs. 79914 lumican 2. 7 413851 AW897510 Hs. 137387 ESTs 2. 7 451767 A1625014 Hs. 187328 ESTs 2. 7 441668 Al611973 Hs. 136313 ESTs 2. 7 435664 A1032087 Hs. 269819 ESTs 2. 7 435046 AA662772 Hs. 174330 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 7 439467 AW292275 Hs. 158365 ESTs 2. 7 441329 A1203575 Hs. 46821 hypothetical protein FLJ20086 2. 7 426925 NM 001196 Hs. 315689 HomosapienscDNA : FU22373 fis, clone H 2. 7 427241 AA399988 Hs. 112087 HumanDNAsequenhomcloneRP11-530N1 2. 7 449919 A1674685 Hs. 200141 ESTs 2. 7 458070 AW503578 Hs. 209406 ESTs, Weakly similar to 138600 zinc fing 2. 7 444794 A1419991 Hs. 145225 ESTs 2. 7 410781 A1375672 Hs. 165028 ESTs 2. 7 449520 R34993 Hs. 226666 ESTs, Moderately similar to 154374 gene 2. 7 439481 AF086294 Hs. 125844 ESTs 2. 7 401702 NM001171' : HomosapiensATP-bindingcass 2. 7 432890 NM014442 Hs. 279751 sialic acid binding tg-hkeiectn 8 2. 7 435545 AA687415 Hs. 28107 ESTs 2. 7 416422 H60457 ESTs ModeratelysimilartoZN91 HUMANZ 2. 7 429415 Nom-002593 Hs. 202097 procollagen Gendopeptidase enhancer 2. 7 420982 AW576160 Hs. 100729 KIAA0692 protein 2. 7 431421 AW969118 Hs. 108144 ESTs, Weakly similar to unnamed protein 2. 7 444168 AW379879 gb : RC1-HT0256081199-011-fO1HT0256Homo 2. 7 419964 AA811657 Hs. 220913 ESTs 2. 7 424480 AA341442 Hs. 205299 ESTs 2. 7 436314 A1983409 Hs. 189226 ESTs 2. 7 405516 ENSP00000200457* : Thyroid receptor intera 2. 7 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 2. 7 457876 A1821940 ESTs, Moderately similar to ALU8_HUMAN A 2. 7 423799 AW026300 Hs. 132906 19A24 protein 2. 7 422551 AW967284 gb : EST379359 MAGE resequences, MAGJ Homo 2. 7 404592 NM022739' : Homo sapiens E3 ubiquitin lig 2. 7 424200 AA337221 gb : EST4944 Endometrial tumor Homo sapie 2. 7 428612 AA770001 Hs. 188778 ESTs 2. 7 446139 H77395 Hs. 39749 ESTs 2. 7 440478 A1733047 Hs. 130005 ESTs 2. 7 429612 AF062649 Hs. 252587 pituitary tumor-transforming 1 2. 7 422530 AW972300 Hs. 118110 bone marrow stromal cell antigen 2 2. 7 423713 AW754182 gb : RC2-CT0321-131199-011cOl CT0321 Homo 2. 7 402032 ENSP00000251056' : Plasma membrane calcium 2. 7 424186 Api536021 Hs. 288706 Homo sapiens CDNA FU 10281 fis, clone HE 2. 7 402799 Target Exon 2. 7 423352 AA324808 Hs. 193576 ESTs 2. 7 412021 AW885592 gb : RC4-OT0071490300-011-g11 OT0071 Homo 2. 7 458617 Z25900 Hs. 18724 Homo sapiens mRNA ; cDNA DKFZp564F093 (fr 2. 7 404170 NM_000636' : Homo sapiens superoxide dismu 2. 7 410886 AW809324 gb : MR4-ST0121-141099-010-G06 1 ST0121 Ho 2. 7 414988 C17535 gb : C17535 Human placenta cDNA (TFujiwara 2. 7 450325 A1935962 Hs. 26289 ESTs 2. 7 458918 H56499 Hs. 252692 ESTs, Weakly similar to 138022 hypotheG 2. 7 405760 Target Exon 2. 7 406789 A1041403 dbosomal protein L29 2. 7 424686 AA345504 gb : EST51529GallbladderilHomosapiens 2. 7

400335 Y13187 Hs. 248068 Homo sapiens dmd gene, intron 11 2. 7 435065 BE064391 gb : RC4-BT0310-110300-015-b08BT0310Homo 2. 7 419373 NM_003244 Hs. 90077 TG-interacting factor (TALE family homeo 2. 7 406785 AA588061 gb : nk10d03. s1 NCI CGAP Co2 Homo sapiens 2. 7 433006 BE242758 Hs. 190223 ESTs. Moderately similar to T29285 hypot 2. 7 428690 A1948490 Hs. 98765 ESTs 2. 7 432692 AW974944 Hs. 200577 ESTs 2. 7 439699 AF086534 Hs. 187561 ESTs, Moderately similar to ALU1 HUMAN A 2. 7 452811 AA937079 Hs. 118983 hypothetical protein FLJ12150 2. 6 457035 AA398074 Hs. 119143 ESTs, Moderately similar to KIAAt513 pro 2. 6 427725 U66839 Hs. 180533 mitogen-acbvated protein kinase kinase 2. 6 433681 A1004377 Hs. 200360 Homo sapiens cDNA FLJ13027 fis, done NT 2. 6 423748 A1149048 Hs. 30211 hypothetical protein FLJ22313 2. 6 422764 A1767727 Hs. 47522 ESTs 2. 6 403431 Target Exon 2. 6 439332 AW842747 Hs. 300870 Homo sapiens mRNA ; cDNA DKFZp547M072 (fr 2. 6 412749 AA378417 Hs. 74564 signal sequence receptor, beta (transloc 2. 6 409703 NM_006187 Hs. 56009 2'-5'-oligoadenylate synthetase 3 (100 k 2. 6 405717 CX000838 : gil10092633lref'; NP 055314. 11pu 2. 6 426503 AA380153 gb : EST93093 Skin tumor I Homo sapiens cD 2. 6 414039 M83221 Hs. 858 v-rel avian retculoendotheliosis viral 2. 6 452683 A1089575 Hs. 9071 progesterone membrane binding protein 2. 6 447587 AW292139 Hs. 115789 ESTs 2. 6 408605 AF025374 Hs. 46465 T-cell, immune regulator 1 2. 6 407103 AA424881 Hs. 256301 hypothetical protein MGC13170 2. 6 427395 AW298741 Hs. 97861 ESTs, Moderately similar to 138022 hypot Z6 435113 AA665469 Hs. 117136 ESTs 2. 6 419015 T79262 Hs. 14463 ESTs 2. 6 427648 A1376722 Hs. 180062 proteasome (prosome, macropain) subunit, 2. 6 453707 AW003879 Hs. 126522 Homo sapiens, clone MGC : 16722, mRNA, com 2. 6 411927 BE274009 Hs. 772 glycogen synthase 1 (muscle) 2. 6 404053 Target Exon 2. 6 415069 AA159831 Hs. 29286 ESTs, Weakly similar to 149636 DNA-bindi 2. 6 449625 NM_014253 odz (odd Oz/ten-m, Drosophila) homolog 1 2. 6 438033 T26483 Hs. 6059 EGF-containing fibulin-like extracellula 2. 6 451593 AF151879 Hs. 26706 CGI-121 protein 2. 6 435828 AA700705 Hs. 13852 ESTs 2. 6 443753 AW367578 Hs. 134749 ESTs 2. 6 416097 BE387371 Hs. 118964 hypothetical protein FLJ20085 2. 6 413986 Z43567 gb : HSC1FC021 normalized infant brain cDN 2. 6 439755 AW748482 Hs. 77873 B7 homolog 3 2. 6 408371 AF161545 Hs. 44439 hypothetical protein 2. 6 445658 A1469062 Hs. 172660 ESTs 2. 6 438166 N30158 Hs. 122645 ESTs 2. 6 449426 T92251 Hs. 198882 ESTs 2. 6 422605 H16646 Hs. 118666 hypothetical protein PP591 2. 6 415788 AW628686 Hs. 78851 KIAA0217 protein 2. 6 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 2. 6 400295 W72838 Ai905687 : IL-BT09S190199-019 BT095 Homo 2. 6 441128 AA570256 ESTs, Weakly similar to T23273 hypotheti 2. 6 420372 AW960049 Hs. 293660 Homo sapiens, clone IMAGE : 3535476, mRNA, 2. 6 428977 AK001404 Hs. 194698 cyclin B2 2. 6 424278 AK000723 Hs. 144517 hypothetical protein FU20716 2. 6 445211 BE045601 Hs. 118248 ESTs, WeaklysimilartoYC18 HUMANHYPOT 2. 6 412715 NM_000947 Hs. 74519 primase, polypeptide 2A (58kD) 2. 6 417838 R24713 Hs. 22514 ESTs 2. 6 420670 AW973577 ESTs 2. 6 403267 Target Exon 2. 6 454354 AW389896 gb : RC4-ST0173191099-03212 ST0173 Homo 2. 6 452903 A1953425 Hs. 345291 ESTs, Weakly similar to 138022 hypotheti 2. 6 427830 AA416598 Hs. 98233 ESTs 2. 6 435953 A1767087 Hs. 114142 ESTs 2. 6 430744 AA485229 Hs. 105649 ESTs 2. 6 413335 A1613318 Hs. 48442 ESTs 2. 6 416370 N90470 Hs. 203697 ESTs, Weakly similar to 138022 hypotheti 2. 6 431865 AA521106 Hs. 136375 ESTs, Weakly similar to S65824 reverse t 2. 6 434274 AA628539 Hs. 1 16252 ESTS, Moderately similar to ALU 1-HUMAN A 2. 6 447854 AW138454 Hs. 11594 ESTs 2. 6 412799 Api267606 gb : aq91hO3. x1 Stanley Frontal SB pool 1 2. 6 455409 AW936832 gb : PM2-DT0023-050400-003-h03 DT0023 Homo 2. 6 408212 AA297567 Hs. 43728 hypothetical protein 2. 6 453055 AW291436 Hs. 31917 Homo sapiens, clone MGC : 9658, mRNA, comp 2. 6 443539 A1076182 Hs. 134074 ESTs, ModeratelysimilartoALU6_HUMANA 2. 6 434898 AW500458 Hs. 29956 KIAA0460 protein 2. 6 438118 AW753311 Hs. 346690 ESTs 2. 6 431786 AW452784 Hs. 220718 ESTs 2. 6 421689 N87820 Hs. 106826 KIAA1696 protein 2. 6 429597 NM 003816 Hs. 2442 adisintegrinandmetalloproteinasedoma 2. 6 424684 AW752714 Hs. 5174 ribosomal protein S17 2. 6 439823 AW665287 Hs. 124514 ESTs 2. 6 411962 AA099050 gb : zk85d12. r1SoarespregnantuterusNbH 2. 6 445774 A1254165 Hs. 339968 ESTs 2. 6 400492 C10001573' : gil73027491gblAAF57827. 11 (AE 2. 6

450625 AW970107 gb : EST382188 MAGE resequences, MAGK Homo 2. 6 426931 NM003416 Hs. 2076 zinc finger protein 7 (KOX 4, clone HF. 1 2. 6 440131 A1023425 Hs. 222225 ESTs 2. 6 438525 AW368528 Hs. 100855 ESTs 2. 6 412247 AF022375 Hs. 73793 vascular endothelial growth factor 2. 6 406662 X62006 Hs. 172550 polypyrimidine tract binding protein (he 2. 6 443725 AW245680 Hs. 9701 growth arrest and DNA-damage-inducible, 2. 6 402260 NM 001436' : Homo sapiens Mann (FBL 2. 6 429599 AA806106 Hs. 123664 ESTs 2. 6 429562 Api732767 Hs. 158101 Homo sapiens CDNA FU 14673 fis, clone NT 2. 6 432527 AW975028 Hs. 102754 ESTs 2. 6 434420 AA688278 Hs. 194864 hypothetical protein FU22578 2. 6 452732 BE300078 Hs. 80449 Homo sapiens, clone IMAGE : 3535294, mRNA, 2. 6 424408 A1754813 Hs. 146428 collagen, type V, alpha 1 2. 6 413151 H47969 Hs. 141971 ESTs, Weakly similar to ALU 1 _HUMAN ALU S 2. 6 416244 N39535 Hs. 32748 ESTs 2. 6 403104 C8000064-: gil1B432393lemblCACl0283. 1 ; (A Z6 400780 NM007325* : Homo sapiens glutamate recept 2. 6 433009 AA761668 gb : nz24c08. s1 NCI CGAP_GCB1 Homosapiens 2. 6 424090 X99699 Hs. 139262 XIAP associated factor-1 2. 6 403212 NM019595 : Homo sapiens intersectin 2 (IT 2. 6 407855 R54126 Hs. 40500 similar to S. cerevisiae RER1 2. 6 406849 AA454809 Hs. 172928 coliagen, type 1, alpha 1 2. 6 443462 Al054690 Hs. 171176 ESTs 2. 6 439963 AW247529 Hs. 6793 piateiet-activating factor acetylhydrola 2. 6 450089 A1681883 Hs. 209546 ESTs. Weakly similar to 2109250A B cell 2. 6 419571 AW674962 Hs. 91146 protein kinase D2 2. 6 448140 AF146761 Hs. 20450 BCM-like membrane protein precursor 2. 6 444881 A1623288 Hs. 192805 ESTs 2. 6 420658 AW965215 Hs. 130707 ESTs 2. 6 437634 AW293046 Hs. 255158 ESTs 2. 6 426894 A1204209 Hs. 143911 ESTs 2. 6 428467 AK002121 Hs. 184465 hypothetical protein Fou 11259 2. 6 434171 BE247688 Hs. 347349 KIAA0948 protein 2. 6 410174 AA306007 Hs. 59461 DKFZP434C245 protein 2. 6 427245 AA421022 Hs. 97739 ESTs 2. 5 437085 AA743935 Hs. 202329 ESTs 2. 5 400362 AF068294 Hs. 272414 Homo sapiens HDCMB45P mRNA, partial cds 2. 5 452221 C21322 Hs. 288057 hypothetical protein FW22242 2. 5 439079 AF085937 Hs. 38348 ESTs 2. 5 437287 AA748180 Hs. 159346 hypothetical protein FU21369 2. 5 411852 AA528140 Hs. 107515 ESTs, Weakly similar to T00329 hypotheti 2. 5 427624 AA406245 Hs. 24895 ESTs 2. 5 435177 A1018174 Hs. 42936 ESTs 2. 5 449433 A1672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 2. 5 447853 AM34204 Hs. 164285 ESTs, Weakly similar to AFG1_YEAST AFG1 2. 5 416704 H77795 Hs. 39785 ESTs 2. 5 401696 Target Exon 2. 5 445677 H96577 Hs. 6838 ras homolog gene family, member E 2. 5 413840 Api301558 Hs. 146381 RNA binding motif protein, X chromosome 2. 5 437916 BE566249 Hs. 20999 hypothetical protein FLJ23142 2. 5 420289 N55394 Hs. 96398 8-oxoguanine DNA glycosylase 2. 5 421848 X15880 Hs. 108885 collagen, type VI, alpha 1 2. 5 421234 AA907153 Hs. 190060 ESTs 2. 5 414598 A1094221 Hs. 135150 lung type-I cell membrane-associated gly 2. 5 420162 BE378432 Hs. 95577 cyclin-dependent kinase 4 2. 5 458199 AW136417 hypothetical protein FLJ14464 2. 5 433523 H29882 ESTs 2. 5 429125 AA446854 Hs. 271004 ESTs, Weakly similar to t38022 hypthe6 2. 5 418399 AF131781 Hs. 84753 hypothetical protein FLJ12442 2. 5 404748 ENSP00000238177' : Similar to kynurenine 3 2. 5 413507 BE145360 Hs. 190064 ESTs, Weakly similar to 138022 hypotheti 2. 5 418886 AA993982 Hs. 130858 ESTs 2. 5 429359 W00482 Hs. 2399 matrix metalloproteinase 14 (membrane-in 2. 5 452367 U71207 Hs. 29279 eyesabsent (Drosophila) homolog2 2. 5 436258 AW867491 Hs. 107125 plasmalemma vesicle associated protein 2. 5 459527 AW977556 Hs. 291735 ESTs, Weakly similar to 178885 senne/th 2. 5 450543 Api394037 Hs. 170296 Homo sapiens cDNA : FU22090 fis, clone H 2. 5 434818 AA650097 Hs. 5996 ESTs 2. 5 444534 AW271626 Hs. 42294 ESTs 2. 5 452113 Al859393 gb : wm11a02. x1NaCGAPUt4 Homo sapiens 2. 5 429115 AA446728 Hs. 289020 Homo sapiens cDNA FLJ 14098 fis, clone MA 2. 5 434012 AA621425 Hs. 186256 ESTs 2. 5 447143 AW292408 Hs. 152290 ESTs, HighlysimilartoJC2463vasoæ6v 2. 5 449505 A1653006 Hs. 195374 ESTs 2. 5 419817 AA743434 Hs. 193778 ESTs 2. 5 457986 AA781745 Hs. 126920 Homo sapiens, clone I MAGE : 4299555, mRNA, 2. 5 431454 AW975980 Hs. 292918 ESTs 2. 5 425018 BE245277 Hs. 154196 E4F transcription factor 1 2. 5 427513 A1476318 Hs. 192480 ESTs 2. 5 441318 Af078234 Hs. 176130 ESTs 2. 5 424830 AW270580 Hs. 189311 ESTs, Weakly similar to putative p150 (H 2. 5 414271 AK000275 Hs. 75871 protein kinase C binding protein 1 2. 5

446089 Api860021 Hs. 345028 ESTs. Moderately similar to A47582 B-cel 2. 5 415983 Api436798 Hs. 117078 Homo sapiens cDNA : FU23028 fis, done L 2. 5 408292 AW178363 gb : RC3-HT0105-010999-002-HO6 HT0105 Homo 2. 5 446862 AV660697 Hs. 282700 ESTs 2. 5 448970 AW138582 gb : UI-H-Bt1-acw-a-06-0-Ul. s1 NCI CGAP_Su 2. 5 459200 Y09306 Hs. 30148 homeodomain-interacting protein kinase 3 2. 5 422627 BE336857 Hs. 118787 transforming growth factor, beta-induced 2. 5 433388 A1432672 Hs. 288539 hypothetical protein FU22191 2. 5 436222 A1208737 Hs. 122810 Homo sapiens CDNA FU 11489 fis, clone HE 2. 5 441255 R06350 Hs. 171635 ESTs 2. 5 441627 AA947552 Hs. 58086 branched chain aminotransferasel. cytos 2. 5 438714 AA814859 Hs. 294112 ESTs 2. 5 441020 W79283 Hs. 35962 ESTs 2. 5 418291 BE300369 Hs. 289038 hypothetical protein MGC4126 2. 5 434267 A1206589 Hs. 116243 ESTs 2. 5 446821 W03766 tropomodulin 3 (ubiquitous) 2. 5 402615 C1003844-: gil6912550lneqNP_036433. 1lol 2. 5 416845 H95279 Hs. 293788 gb : yu20h02. s1 Soaresfetal liverspleen 2. 5 408253 AW807476 Hs. 21051 Homo sapiens mRNA for FU00012 protein, 2. 5 444884 A1201094 Hs. 148540 ESTs 2. 5 440826 AW383618 Hs. 346256 ESTs, Moderately similar to ALU2_HUMAN A 2. 5 431374 BE258532 Hs. 251871 CTP synthase 2. 5 458093 Api207788 Hs. 343628 sialyltransferase 4B (beta-galactosidase 2. 5 422484 AA568770 Hs. 123158 Homo sapiens cDNA FW12630 hs, clone NT 2. 5 442804 AW300118 Hs. 131257 ESTs 2. 5 420949 AA934063 Hs. 13836 ESTs, Weakly similar to 138022 hypthe6 Z5 451350 Ai791447 gb : ni13aO5. y5 NCI CGAP_Co4 Homo sapiens 2. 5 410855 X97795 Hs. 66718 RAD54 (S. cerevisiae)-like 2. 5 430426 AA478807 Hs. 125173 ESTs 2. 5 418526 BE019020 Hs. 85838 solute carrier family 16 (monocarboxylic 2. 5 406290 Target Exon 2. 5 442085 AA975688 Hs. 159955 ESTs 2. 5 448148 NM016578 Hs. 20509 HBV pX associated protein-8 2. 5 432888 T86823 gb : yd81aO8. s1 Soaresétalliverspleen 2. 5 424126 AA335635 Hs. 96917 ESTs 2. 5 459727 A1906494 gb : RC-BT113060499-024BT113Homosapien 2. 5 407989 AW135208 Hs. 256092 ESTs 2. 5 404571 NM 5902* : Homo sapiens progestin induce 2. 5 429139 F09092 Hs. 66087 ESTs 2. 5 435232 Nom-001262 Hs. 4854 cyclin-dependent kinase inhibitor 2C (p1 2. 5 420608 BE548277 Hs. 103104 ESTs 2. 5 432668 AA558601 Hs. 43296 ESTs 2. 5 406871 AA993857 Hs. 180842 ribosomal protein L13 2. 5 443516 AA305821 Hs. 9527 apoptosis related protein APR-3 2. 5 445985 BE621800 Hs. 29444 putative small membrane protein NID67 2. 5 424614 X54486 Hs. 151242 serine (or cysteine) proteinase inhibito 2. 5 437267 AW511443 Hs. 258110 ESTs 2. 5 458251 AL040927 Hs. 210422 ESTs 2. 5 431198 AL047634 Hs. 231913 ESTs 2. 5 413944 AW001579 Hs. 9645 HomosapiensmRNAforKIM1741 protein, 2. 5 420796 L34355 Hs. 99931 sarcoglycan, alpha (5OkD dystrophin-asso 2. 5 428032 AW997704 Hs. 11493 HomosapienscDNAFW13536hs, clonePL 2. 5 422017 NM003877 Hs. 110776 STATinducedSTATinhibitor-2 2. 5 424662 Nom-002870 Hs. 151536 RAB13, member RAS oncogene family 2. 5 423779 AW071837 Hs. 57971 ESTs 2. 5 405863 Target Exon 2. 5 458421 Al279978 Hs. 22547 ESTs 2. 5 439019 AF085902 Hs. 271737 ESTs 2. 5 412577 Z22968 Hs. 74076 CD163 antigen 2. 5 404891 Target Exon 2. 5 419043 T19167 Hs. 89566 etsvaiantgene1 2. 5 448482 AW294078 Hs. 171092 ESTs 2. 5 426030 BE243933 Hs. 108642 zinc finger protein 22 (KOX 15) 2. 5 429109 AL008637 Hs. 196352 neutrophil cytosolic factor 4 (40kD) 2. 5 450597 A1701635 Hs. 207077 ESTs 2. 5 414386 X00442 Hs. 75990 haptoglobin 2. 5 440473 BE562314 Hs. 98711 Homo sapiens, clone IMAGE : 3677165, mRNA, 2. 5 406851 AA609784 major histocompatibility complex, class 2. 5 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 2. 5 417663 R07483 Hs. 180461 ESTs 2. 5 429341 X73874 Hs. 2393 phosphorylasekinae, alpha1 (muscle) 2. 5 450663 H43540 Hs. 25292 ribonuclease HI, large subunit 2. 5 407198 H91679 gb : yv04a07. s150aesfetaliverspleen 2. 5 411742 AW247593 Hs. 71819 eukaryotic translation initia6on factor 2. 5 409449 H11341 Hs. 13366 HomosapienscDNA : FLJ23567 fis, clone L 2. 5 TABLE 14B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408292 1050507_1 AW178363 AW846011 AW845964 AW845988 AW845977 AW846002

409157 110363 1 AA064631 AA722000 AA064793 409189 110687_1 AA125984 AA127189 AA065075AA070377 AA100017 AA079891 AA113255 AA075168 AA082764 AA083380 N84829 AA084752 AA076512 AA085119 AA085208 AA085045 410886 1225822_1 AW809324 BE144977 BE144956 411537 1248899 1 BE073250 BE073378 BE073379 AW850533 AW850529 411543 1249127 1 AW851248 AW851425 AW850805 AW851021 AW850905 411565 1249756_1 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628 411671 125369 1 BE049094 AA700765 H86770 AA094646 R02483 C03868 N56170 411688 1254076_1 AW953440 T08 189 AW857085 411962 126744 1 AA099050 AA099526 T47733 412021 1272156 1 AW885592 AW885594 AW885579 AW885651 412135 1279148_1 AW895309 AW895290 AW895307 AW895397 AW895378 AW895402 AW895403 AW895311 AW895298 AW895390 AW895488 AW895468 AW895481 AW895288 412799 132817 1 A1267606M121045M126521 412811 1 32943 1 H06382 AW957730 M35201 4 R1 3591 M1 21201 D60420 BE263253 BE047862 Z41952 AI424991 AI693507 AI863108 AA5990 A1091148 AA598689 R39887 AA813482 AW016452 H06383 R41807 Al364268 M620528 A1241940 AW089149 AW090733AW088875 Z38240 AA121202 R17734 413986 140720_1 Z43567H24159M134240 414372 143909 1 AAt43654 AW753140 AA213770 AW970865 AA569075 AA492132 414988 1511316 Cl 7535 D59244 D58878 079090 415131 1523680 1 D61119 D81508 D81734 416422 1593811 1 H60457 H68709 H73528 H54335 R87154 416569 1601567 1 H64891 R93444 R93458 R05590 416871 1626761 1 H98716 N90792 N24283 416913 163001 1 AW934714BE161007BE762500AW749902AW749864BE162498BE761005AA19 0449AW5134658E1610068E162499 419896 1888662 1 Z99362 Z99363 420352 192979_1 BE258335 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280 420670 195442, AW973577AA553621AA279187 420886 197344. AA805453AA281379 422551 217767 1 AW967284M312192M312203 423713 231290 1 AW754182 AVY754198 AA329983 424009 234177 1 F11690 AW965370 AA333586 D30830 424200 236595 1 AA337221 AA336756 AW966196 424686 242486 1 AA345504 AA345251 AW963243 424947 245247 1 R77952 AA348809 AW959960 AW959962 A1565552 AW070702 AA973910 R85973 425146 247244 1 AW954627 AW954629 AA351258 R25935 425331 250199_1 AW962128M355353M427363 426503 268283 1 AA380153 AA380233 AW963529 429163 300543 1 AA884766 AW974271 AA592975AA447312 429940 310884 1 W25215 AA461079 AA461391 430535 319643_1 AW968485AW968670M480922BE350425 430968 326269 1 AW972830 AA527647 AA489820 AA570362 432044 340773 1 AW972727 AA524829 AW972733 432363 345469 1 AA534489 AW970240 AW970323 432888 355780 1 T86823 A1821425 A1732232 AA569589 AA570737 433009 357371 1 AA761668 AA573621 R92814 R09670 433523 368873_1 H29882 AW665533 AW149901 Al572917 M598500 Al686466 A1336390AW864390 AW864320 433835 374758 1 A1806185 AA610063 A1693089 A1693075 434589 38929 1 AF147363T47219T47218 435065 399329 1 BE064391 BE064395 AA663613 N99644 435542 407744-1 AA687376 H74234 AW975503 436608 42361 3 AA628980 A1126603 BE504035 437034 431713 1 AA742643 AA808575 AW976668 437437 43709 1 AA226869 AA296516 AW959753 AA186390 AL359619 AA356195 AA148427 R22748 A1033624 BE548853 H95327 AW579751 BE561649 AA397533 BE617136 AA236444 T89946 AA247450 N55777 W38725 A1743846 A1808406 AA922229 A1051464 W04713 R11251 W19656 A1042319 AA489276 A1224533 H 437945 44580 1 T78519 H59898 U72516 438458 457837 1 AW975186 AA807807 D29548 439518 47334_1 W76326AF086341 W72300 439533 47349 1 W76021 AF088052 W72465 439566 47387 1 AF086387 W77884 W72711 439710 47550 1 AF086543 W96291 W96225 441128 51021 2 AA570256 AW014761 AA573721 AI473237 A1022165 AA554071 AA127551 N90525 AW973623 AA447991 AA243852 BE328850 AI148171 AI359627 A1005068 A1356567 AA232991 AW016855 AA906902 AA233101 AA127550 BE512923 442476 543547 1 AF069475 AF069477 AF069476 444016 58899 1 AA448154 AV647571 444168 593829 1 AW379879 A1126285 H12014 446821 69435 1 W03766 A1357775 AV660500 AV660731 448970 791254 1 AW138582 A1638298 A1631640 A1963868 A1611082 449625 81 1 NM 014253 AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760 N48674 A1375997 R45432 D59344 A1203107 F07491 R35360 R25094 A1913631 A1498402 T61382 A1016320 N45526 T61415 AA331486 450166 82677 1 AA429504 R41904 AA279467 H09648 AA007236 450375 83327 1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532 AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 A1161014 AA099554 R69067 450506 836 1 NM 004460 U09278 U76833 AW630055 AW471133 C02434 W45237 AW793518 BE070112 AI587479 AI624429 AW190535 AI446661 AI478772 AW022667 AA528235 AA599775 AW613820 A1435793 AW594230 A1051768 A1200109 A1680296 AA436611 AW609728 W42634 A1682584 AA405569 A1685653 AWO 450625 84032 1 AW970107M513951 M010406 451129 859870-1 BE072881 BE072946 A1762181 451350 866945 1 Al791447AI791327AW886809 452113 899664 1 A1859393 BE177742 452203 903 2 X57522 AW295947 A1346197 Al304693 L21205 L21206 L21207 L21208 L21204 NM_000593 F06770 F12630 X57521 R18264 T74462 AA346259 AW602508AA904076F08426H23432AA313737AA393782M78052AA847441AA 487637AA135770AA353161A ! 819778AA054458A ! 346733 AW361447 A14

453331 96214_1 A1240665 T53681 N77468 H51833 AA147247 R75732 C18450 R73999 A1095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292 R31981 H12498 H02668 AA035018 R75957 AI803329 R27528 R36203 AI809932 AI808765 R78948 AA41 t449 AA976929 A1378760 AI378620 T48870 R7390 453682 977454 1 T79703 T96307 AL079725 454177 1049351 1 AW807321 AW807262 AW177104 AW807319 AW807115 AW807344 AW807324 AW178116 BE141575 AW845849 AW807105 AW845868 BE140942 AW807178 AW807167 AW807398 AW807320 AW807306 AW845866 454354 1129859_1 AW389896 AW389898 AW389906 AW609203 AW389873 454457 1207274 1 AW753456 AW753036 AW854868 AW854862 454581 1225710_1 AW809189 AW809219 AW813574 454765 12339051 AW819629AW854320 454860 1237732 1 AW835767 AW835537 BE160187 454968 1247029 1 AW849046 AW847956 AW849039 AW847957 AW848279 AW848698 AW849034 AW849033 455104 1253737_1 BE064863 BE153698 AW856751 BE153820 BE064737 BE153674 BE064730 BE065062 BE153536 AW856622 BE155079 BE064651 BE153665 BE064650 BE064691 455409 1288355_1 AW936832 AW936609 AW936657 AW936611 AW936739 AW936734 AW936779 AW936688 AW936659 AW936738 AW936827 AW936737 AW936736 AW936740 AW936833 AW936777 AW936830 AW936834 AW936829 AW936772 AW936638 AW936658 AW936636 AW936774 AW936778 AW936766 AW936776 AW936831 AW9 455481 1293182J AW948317 AW948322 AW948329 AW948316 AW948298 AW948330 AW948325 AW948324 455646 1348557 1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 455778 13645061 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 455899 1381547 1 BE155112 BE155154 BE155087 BE155247 BE155499 BE155367 BE155452 456304 176820 1 AI820973 A1734077 AI820984 AA225796 AA225060 AA225101 457364 328154_1 AW971037M508019M492345 457876 42814 2 AI821940 N67106 AI744264 AA808846 AA643417 AA643416 Z70715 458199 504866 1 AW136417 A1141026 A1340960 A1091670 AI523802 AW572908 Al458860 Al924374 A1830572 A1400702AI337539 A1968111 Al521308AI492336 Al540779 Al672594 AW665077 AA971810 AA909139 AW082128 Al335251 A1807192 AW511744 A1023232 AI536899 AW207791 Al670910 Al002047 AW4 TABLE 14C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et a !.' refers to the publication entitled The DNA sequence of human chromosome 22"Dunham, et ai. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 400492 9213749 Minus 123881-124090 400533 6981826 Minus 277132-277595 400645 8117693 Minus 58471-58716 400658 8118459 Minus 73525-73644 400780 8131663 Minus 118372-118619 400850 1927150 Minus 4506-4691 400924 7107613 Minus 30309-30498 401272 9797373 Minus 98374-98509 401454 9186923 Minus 114659-114832 401696 3417290 Minus 46209-46401 401702 1871197 Minus 68182-68325 401841 7684597 Plus 89868-90006, 91920-92085 402032 7656761 Plus 62293-62475 402082 8117478 Minus 190046-190183 402229 9965022 Minus 15739-15951, 16166-16779 402239 7690131 Plus 38175-38304, 42133-42266 402260 3399665 Minus 113765-113910, 115653115765, 116808-116940 402274 2935596 Plus 5604-6527 402604 9909420 Plus 20393-20767 402615 9926801 Plus 131390-132157 402799 3355547 Plus 35718-35899 402855 9662953 Minus 59763-59909 402936 8894303 Plus 51655-51771 403011 6693597 Minus 3468-3623 403104 7331404 Minus 41800-41973 403108 8980955 Plus 93253-93667 403212 7630897 Minus 156037-156210 403267 7887182 Plus 116078-121885 403288 8081479 Plus 133763-133899, 135813-135958 403290 8083176 Plus 19288-20076 403291 7230870 Plus 95177-95435 403349 8569773 Minus 167815-168374 403361 8570313 Minus 112496-112687 403431 7139839 Plus 56509-56860 403481 9965004 Plus 9349G93633 403696 3135242 Minus 143467-143634 403790 8084957 Minus 87826-87947, 89835-90002 403849 7708855 Plus 95043-96519 403942 7711825 Minus 99606-99757 403961 7596976 Minus 110393-110603 403969 8569909 Plus 3123731375. 32405-32506 404053 3548785 Plus 61797-64205 404120 7342152 Plus 135775-136000 404150 7534008 Plus 165811-165943 404170 9930793 Plus 168836-169248 404209 5006246 Minus 11247-11514 404272 9885189 Plus 83207-83355, 84358-84496, 90519-90720, 91371-91447 A j S

404407 7329316 Minus 48154-48499 404571 7249169 Minus 112450-112648 404584 9857511 Plus 138651-139153 404592 9943965 Minus 39067-39225 404632 9796668 Plus 45096-45229 404748 7263437 Plus 11446-11591 404891 7329392 Plus 84974-85125 405046 7596829 Minus 4373-4528 405141 8980911 Plus 99861-100054 405183 7209940 Plus 12335-12653 405238 7249119 Minus 51728-51836 405348 2914717 Minus 43310-43462 405516 9454624 Plus 112707-112876, 113676-113854 405558 1621110 Plus 4502-4644. 5983-6083 405605 5836195 Minus 117070-117270 405717 9588573 Plus 11275-11973 405760 6066938 Minus 37424-38045 405863 7657810 Plus 49410-49620 405941 6758796 Plus 2798-3444 406060 6899623 Minus 20339-20746 406290 5686274 Plus 8711-9358 406395 9256242 Minus 20805-20960 406478 9857502 Plus 68314-68523, 6885368950 406481 9864741 Minus 91439-91579 TABLE 15A : ABOUT 1033 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES Table 15A lists about 1033 genes up-regulated in glioblatoma compared to normal normal adult tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of"average'glioblastoma to'average'normal tissues was greater than or equal to 3. 0. The average glioblabma bvel wa set to the 8Sa percent amongst various brain tumors. The'average'normal Gssue level was set to the 85° percentile amongst various non-malignant adult tissues. In order to remove gene- specific background levels of non-specific hybridization, the 1011 percentile value amongst the various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene tiUe R1 : Ratio of GLIOBLASTOMA to NORMAL ADULT TISSUES Pkey ExAccn UnigenelD Unigene Title R1 427343 A1880044 Hs. 176977 protein kinase C binding protein 2 60. 5 431917 D16181 Hs. 2868 peripheral myelin protein 2 54. 9 418375 NM_003081 Hs. 84389 synaptosomal-associated protein, 25kD 53. 1 428321 A1699994 Hs. 2868 peripheral myelin protein 2 49. 6 409389 AB007979 Hs. 301281 Homo sapiens mRNA, chromosome 1 specific 45. 4 435147 AL133731 Hs. 4774 Homo sapiens mRNA ; cDNA DKFZp761C1712 (f 43. 9 413472 BE242870 Hs. 75379 solute carrier family 1 (glial high affi 42. 7 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 42. 3 456759 BE259150 Hs. 127792 delta (Drosophila)-like3 39. 1 430838 N46664 Hs. 169395 hypothetical protein FLJ12015 37. 9 417183 R52089 Hs. 172717 ESTs 37. 6 426325 D28114 Hs. 169309 myelin-associated oligodendrocyte basic 36. 5 425088 AA663372 Hs. 169395 hypothetical protein FLJ12015 34. 3 429007 D80642 gb : HUM092E09B Human fetal brain (TFujiwa 33. 9 449494 AW237014 Hs. 315369 HomosapienscDNA FW23075fis, cloneL 33. 9 423849 AL157425 Hs. 133315 HomosapiensmRNA ; cDNADKFZp761J1324 (f 32. 7 429276 AF056085 Hs. 198612 G protein-coupled receptor 51 32. 3 413333 M74028 Hs. 75297 fibroblast growth factor 1 (acidic) 29. 0 450133 AW969769 Hs. 105201 ESTs 27. 9 412733 AA984472 Hs. 74554 KIAA0080 protein 27. 6 425842 A1587490 Hs. 159623 NK-2 (Drosophila) homolog B 27. 3 416829 AB013805 Hs. 80220 catenin (cadhenn-associatedprotein), d 27. 1 424140 Z48051 Hs. 141308 myelin oligodendrocyte glycoprotein 25. 2 402604 Target Exon 24. 3 437204 AL110216 Hs. 22826 ESTs, Weakly similar to 155214 salivary 24. 3 422656 A1870435 Hs. 1569 LIM homeobox protein 2 23. 6 447359 NM012093 Hs. 18268 adenylate kinase 5 23. 3 436878 BE465204 Hs. 47448 ESTs 22. 9 435708 A1362949 Hs. 75169 ESTs 22. 9 429903 AL134197 Hs. 93597 cyclin-dependentkinaeS, egulatorysu 22. 7 439239 A1031540 Hs. 235331 ESTs 22. 4 409395 U46745 Hs. 336678 dystrobrevin, alpha 22. 2 425799 T08133 Hs. 182906 Homo sapiens mRNA for KIM1872 pnztein, 21. 9 425057 AA826434 Hs. 1619 achaete-scute complex (Drosophila) homol 21. 3 444378 R41339 Hs. 47860 neurotrophictyrosinekinase. receptor. 21. 2 444513 AL120214 Hs. 7117 glutamate receptor, ionotropic, AMPA 1 21. 0 419078 M93119 Hs. 89584 insulinoma-associated 1 21. 0 425048 H05468 Hs. 164502 ESTs 20. 9 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 19. 3 423853 AB011537 Hs. 133466 slit (Droæphila) homolog1 19, 3 418110 R43523 Hs. 217754 hypothetical protein FU22202 19. 2 447004 AW296968 Hs. 157539 ESTs 18. 6 439415 F05538 Hs. 4273 ESTs 18. 6 441497 R51064 Hs. 23172 ESTs 18. 5

425523 AB007948 Hs. 158244 KIAA0479 protein 18. 3 413597 AW302885 Hs. 117183 ESTs 18. 2 433551 Al985544 Hs. 12450 protocadhedn 9 7 428392 H10233 Hs. 2265 secretory granule, neuroendocrine protei 17. 3 453642 A1370936 Hs. 34074 dipeptidylpeptidase Vi 17. 3 418338 NM 002522 Hs. 84154 neuronatpentraxint 17. 1 437268 Al754847 Hs. 227571 regulator of G-protein signalling 4 16. 8 408604 D51408 Hs. 21925 ESTs 16. 6 424581 M62062 Hs. 150917 catenin (cadherin-associated protein), a 16. 6 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (C/EBP), 16. 5 448302 Api480208 Hs. 182906 Homo sapiens mRNA for KIAA1872 protein, 16. 4 429466 M85835 Hs. 12827 ESTs 16. 3 441350 AB020690 Hs. 7782 paraneoplas6c antigen MA2 15. 9 448672 A1955511 Hs. 225106 ESTs 15. 8 448743 AB032962 Hs. 21896 KIAA1136 protein 15. 7 415910 U20350 Hs. 78913 chemokine (GXC) receptor 1 15. 3 441285 NM002374 Hs. 167 microtubule-associated protein 2 15. 2 431019 NM 005249 Hs. 2714 forkheædboxG1B 14. 8 431941 AK000106 Hs. 272227 Homo sapiens cDNA FLJ20099 fis, clone CO 14. 3 433800 A1034361 Hs. 135150 lung type-I cell membrane-associated gly 14. 3 416370 N90470 Hs. 203697 ESTs, Weakly similar to 138022 hypotheti 14. 1 439979 AW600291 Hs. 6823 hypothetical protein FW10430 14. 0 444471 AB020684 Hs. 11217 KIAA0877 protein 13. 9 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 13. 8 448595 AB014544 Hs. 21572 KIAA0644 gene product 13. 6 441440 A1807981 Hs. 30495 ESTs 13. 6 428982 Nom005097 Hs. 194704 leucine-rich, glioma inactivated 1 13. 5 424790 AL119344 Hs. 13326 ESTs, Weakly similar to 2004399A chromos 13. 3 459516 A1049662 Hs. 246858 EST 13. 2 421264 AL039123 Hs. 103042 microtubule-associated protein 1B 13. 2 428342 AI739168 Homo sapiens cDNA FW 13458 fis, clone PL 13. 1 408562 A1436323 Hs. 31141 Homo sapiens mRNA for KIAA1568 protein, 12. 9 412959 D87458 Hs. 75090 KIAA0282 protein 12. 9 439199 R40373 Hs. 26299 ESTs 12. 8 423419 R55336 Hs. 23539 ESTs 12. 5 445495 BE622641 Hs. 38489 ESTs, Weakly similar to 138022 hypotheti 12. 4 415849 R20529 Hs. 6806 ESTs 12. 4 452372 A1885742 Hs. 228474 ESTs 12. 4 452744 A1267652 Hs. 246107 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 12. 3 426344 H41821 Hs. 322469 transcriptional activator of the c-fos p 12. 2 415734 NM014747 Hs. 78748 KIAA0237 gene product 12. 1 426269 H15302 Hs. 168950 Homo sapiens mRNA ; cDNA DKFZp566A1046 (f 12. 1 444119 R41231 Hs. 184261 ESTs, Weakly similar to T26686 hypotheti 12. 0 409049 Al423132 Hs. 146343 ESTs 11. 9 434277 X77748 Hs. 3786 glutamatereceptor, metabotropic3 11. 9 427897 NM_017413 Hs. 303084 apelin ; peptide ligand for APJ receptor 11. 8 453941 U39817 Hs. 36820 Bloom syndrome 11. 8 424120 T80579 Hs. 290270 ESTs 11. 7 418738 AW388633 Hs. 6682 soiute carrier famify 7. (cationicamino 11. 7 411305 BE241596 Hs. 69547 myelinbaicprotein 11. 7 424945 A1221919 hypothetical protein FLJ10582 11. 6 449539 W80363 Hs. 58446 ESTs 11. 5 409638 AW450420 Hs. 21335 ESTs 11. 5 441016 AW138653 Hs. 25845 ESTs 11. 4 429037 X81895 Hs. 194765 H. sapiensGENX-5624mRNA, 3 UTR 11. 3 407034 U84540 gb : Human dystrobrevinisoform DTN-3 (DTN 11. 2 446372 AB020644 Hs. 14945 long fany æyl-CoA synthetase 2 gene 11. 2 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 11. 2 424432 AB037821 Hs. 146858 protocadherin 10 424893 AW295112 Hs. 153648 Homo sapiens cDNA FLJ13303 fis, clone OV 11. 1 425649 U30930 Hs. 158540 UDPglycosyltransferase8 (UDP-galætose 11. 1 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 11. 1 423678 AW963357 Hs. 7847 ESTs 10. 7 446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 10. 7 430691 C14187 Hs. 103538 ESTs 10. 7 428728 NM 016625 Hs. 191381 hypothetical protein 10. 6 427701 AA411101 Hs. 243886 nuclear autoantigenic sperm protein (his 10. 6 431988 AC002302 Hs. 77202 protein kinase C, beta 1 10. 5 433896 AW294729 Hs. 274461 ESTs 10. 5 431467 N71831 Hs. 256398 Homo sapiens mRNA ; cDNA DKFZp434E0528 (f 10. 4 419249 X14767 Hs. 89768 gamma-aminobutyricacid (GABA) A recepto 10. 3 445041 T64183 Hs. 282982 solute carrier 10. 3 446782 A1653048 Hs. 144006 ESTs 10. 2 451952 AL120173 Hs. 301663 ESTs 10. 2 446711 AF169692 Hs. 12450 protocadherin 9 10. 1 438054 AA776626 Hs. 169309 ESTs 10. 1 443785 AW449952 Hs. 190125 basic-helix-loop-helix-PAS protein 10. 1 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 10. 0 419863 AW952691 Hs. 93485 HomosapiensmRNA ; cDNADKFZp761D191 (fr 10. 0 416857 AA188775 Hs. 292453 ESTs 10. 0 435191 R15912 Hs. 4817 Homo sapiens clone 24461 mRNA sequence 10. 0 419271 N34901 Hs. 238532 ESTs 9. 9 429927 NM_001115 Hs. 2522 adenylate cyclase 8 (brain) 9. 9

415293 R49462 Hs. 106541 ESTs 9'9 440184 AB002297 Hs. 7022 dedicator of cyto-kinesis 3 9. 8 452526 W38537 Hs. 280740 hypothetical protein MGC3040 9. 8 427304 AA761526 Hs. 163853 ESTs 9. 7 420547 AF155140 Hs. 98738 gonæotropin-regulated tes6cular RNA he 9. 6 421659 NM 014459 Hs. 106511 protocadherin 17 9. 6 426847 S78723 Hs. 298623 5-hydroxytryptamine (serotonin) receptor 9. 6 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68k0) 9. 5 447101 N72185 Hs. 44189 ESTs 9. 5 442613 Al004002 Hs. 130522 Kv channel-interacting protein 1 9. 5 454027 R40192 Hs. 21527 HumanDNAsequencefromcloneGS1-11SM3 9. 5 445102 AW204610 Hs. 22270 ESTs 9. 5 435793 AB037734 Hs. 4993 KIAA1313 protein 9. 5 437948 AA772920 Hs. 303527 ESTs 9. 5 438209 AL120659 Hs. 6111 aryl-hydrocarbon receptor nuclear transi 9. 4 415170 R44386 Hs. 164578 ESTs 9. 3 415486 H12214 Hs. 13284 ESTs, Weakly similar to 2109260A B cell 9. 2 435501 AW051819 Hs. 129908 KIAA0591 protein 9. 2 416072 AL110370 Hs. 79000 growth associated protein 43 9. 2 442910 A1365130 Hs. 11307 ESTs, Weakly similar to Tl 9326 hypotheb 9. 1 438080 AA777381 Hs. 291530 ESTs, Weakly similar to AWCHUMAN ! ! ! ! 9. 1 425187 AW014486 Hs. 22509 ESTs 9. 1 424028 AF055084 Hs. 153692 Homo sapiens cDNA FW 14354 hs, clone Y7 9. 0 430091 AB032958 Hs. 233023 KIAA 1132 protein 9. 0 427540 R12014 Hs. 20976 ESTs 9. 0 447198 D61523 Hs. 283435 ESTs 9. 0 449611 A1970394 Hs. 197075 ESTs 8. 9 444124 R43097 Hs. 6818 ESTs 8. 9 451996 AW514021 Hs. 245510 ESTs 8. 8 454048 H05626 Hs. 6921 ESTs 8. 8 412266 N59006 Hs. 26133 ESTs 8. 8 433597 AA708205 Hs. 100343 ESTs 8. 7 447342 A1199268 Hs. 19322 Homosapiens, SimilartoRIKENcDNA2010 8. 6 450154 R15891 Hs. 281587 Human (clone CTG-A4) mRNA sequence 8. 6 410102 AW248508 Hs. 279727 ESTs ; homologue of PEiW3 1Ciona savignyi 8. 5 423135 N67655 Hs. 26411 ESTs 8. 5 418097 R45137 Hs. 21868 ESTs 8. 4 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 8. 4 419721 NM 001650 Hs. 288650 aquaporin 4 8. 4 449300 A1656959 Hs. 346514 ESTs 8. 4 436954 AA740151 Hs. 130425 ESTs 8. 3 425354 U62027 Hs. 155935 complement component 3a receptor 1 8. 3 424997 AL138167 Hs. 96920 ESTs 8. 3 442710 A1015631 Hs. 23210 ESTs 8. 2 449625 NM014253 odz (odd Oz/ten-m, Droæphila) homolog 1 8. 2 451625 R56793 Hs. 106576 alanine-glyoxylate aminotransferase 2-li 8. 2 413063 AL035737 Hs. 75184 chitinase 3-like I (carfilage glycoprote 8. 0 449605 AW138581 Hs. 198416 ESTs 8. 0 407886 AW969688 Hs. 100826 ESTs 8. 0 414175 A1308876 Hs. 103849 hypothetical protein DKFZp761D112 7. 9 429946 R49390 Hs. 254129 KIAA1678 7. 9 400293 N51002 Hs. 306480 HomosapiensmRNA ; cDNADKFZp761E2112 (f 7. 9 455601 A1368680 Hs. 816 SRY (sex determining region Y)-box 2 7. 9 409799 D11928 Hs. 76845 phosphoserine phosphatase-like 7. 8 415279 F04237 Hs. 1447 glial fibrillary acidic protein 7. 8 429918 AW873986 Hs. 119383 ESTs 7. 8 449433 A1672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 7. 8 422411 AW749443 Hs. 22511 ESTs 7. 7 448902 Z45998 Hs. 22543 Homo sapiens mRNA ; cDNA DKFZp76111912 (f 7. 7 452355 N54926 Hs. 29202 G protein-coupled receptor 34 7. 7 447414 D82343 Hs. 74376 neuroblastoma (nerve Gssue) protein 7. 7 407168 R45175 Hs. 117183 ESTs 7. 6 448555 A1536697 Hs. 159863 ESTs 7. 6 428536 A1143139 Hs. 2288 visinin-like 1 7. 6 408947 AL080093 Hs. 49117 HomosapiensmRNA ; cDNADKFZpS64N1662 (f 7. 6 420362 U79734 Hs. 97206 hun6ngtin interacting protein 1 7. 6 435624 AF218942 Hs. 24889 formin 2 7. 6 440105 AA694010 Hs. 6932 Homo sapiens clone 23809 mRNA sequence 7. 6 412068 S72043 Hs. 73133 metallothionein 3 (growth inhibitory fac 7. 6 445568 H00918 Hs. 268744 KIAA1796 protein 7. 5 417160 N76497 Hs. 1787 proteolipid protein 1 (Pelizaeus-Meabac 7. 5 423361 AW170055 Hs. 47628 ESTs 7. 5 456965 AW131888 Hs. 172792 ESTs, Weakly similar to hypothetical pro 7. 5 458332 A1000341 Hs. 220491 ESTs 7. 4 409902 A1337658 Hs. 156351 ESTs 7. 3 448321 NM005883 Hs. 20912 adenomatous polyposis coli like 7. 3 420345 AW295230 Hs. 25231 ESTs 7. 3 402855 NM 001839' : Homo sapiens calponin 3, acid 7. 2 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 7. 2 425741 AF052152 Hs. 159412 Homo sapiens clone 24628 mRNA sequence 7. 2 448986 H42169 Hs. 347310 hypothetical protein FU14627 7. 2 415651 A1207162 Hs. 3815 stathmin-like-protein RB3 7. 2 412709 AL022327 Hs. 74518 KIAA0027 protein 7. 1

451621 A1879148 Hs. 26770 fatty acid binding protein 7, brain 7. 1 445745 AB007924 Hs. 13245 KIAA0455 gene product 7. 1 439451 AF086270 Hs. 276554 heterochromatin-like protein 1 7. 1 418030 BE207573 Hs. 83321 neuromedin B 7. 1 400292 AA250737 Hs. 72472 BMP-R1B 7. 1 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Circadian Oscilla 7. 0 440435 AL042201 Hs. 21273 transcription factor NYD-splO 7. 0 414696 AF002020 Hs. 76918 Niemann-Pick disease, type Cl 7. 0 417417 F05745 Hs. 89512 ATPase, Ca transporting, plasma membrane 7. 0 440152 AB002376 Hs. 7006 KIAA0378 protein 7. 0 422960 AW890487 Hs. 63984 cadherin 13, H-cadherin (heart) 7. 0 454293 H49739 Hs. 134013 ESTs, ModeratelysimilartoHK61_HUMANH 7. 0 447197 R36075 gb : yh88bO1. s1 Scares placenta Nb2HP Homo 7. 0 426814 AF036943 Hs. 172619 myelin transcription factor 1-like 6. 9 416836 D54745 Hs. 80247 cholecystokinin 6. 9 447350 A1375572 Hs. 172634 ESTs 6. 9 440074 AA863045 Hs. 10669 ESTs, Weakly similar to T00050 hypotheb 6. 9 436039 AW023323 Hs. 121070 ESTs 6. 9 444396 T65213 Hs. 4257 ESTs 6. 9 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypothe6 6. 9 438330 AW450572 Hs. 257316 ESTs 6. 8 410305 AF030409 Hs. 62185 solutecanierfamily9 (sodium/hydrogen 6. 8 421141 AW117261 Hs. 125914 ESTs 6. 7 412788 AA120960 Hs. 198416 ESTs 6. 7 411078 A1222020 Hs. 182364 CocoaCrisp 6. 7 443455 AB001025 Hs. 9349 ryanodine receptor 3 6. 7 448769 N66037 Hs. 38173 ESTs 6. 7 441523 AW514263 Hs. 301771 ESTs, Weakly similar to ALUF HUMAN ! ! ! ! 6. 7 414214 D49958 Hs. 75819 glycoprotein M6A 6. 6 439845 AL355743 Hs. 56663 Homo sapiens EST from clone 41214, full 6. 6 437036 A1571514 Hs. 133022 ESTs 6. 6 429239 AA448419 Hs. 45209 ESTs 6. 6 434164 AW207019 Hs. 148135 serinetthreonine kinase 33 6. 6 412155 R38167 Hs. 12449 Homo sapiens transmembrane protein HTMP1 6. 5 452834 Al638627 Hs. 105685 KIAA1688 protein 6. 5 441916 AA993571 Hs. 129075 ESTs 6. 5 451516 A1800515 Hs. 12024 ESTs 6. 5 434808 AF155108 Hs. 256150 Homo sapiens, Similar to RIKEN cDNA 2810 6. 5 452461 N78223 Hs. 108106 transcription factor 6. 5 450375 AA009647 a disintegrin and metalloproteinae doma 6. 4 434811 AW971205 Hs. 114280 ESTs 6. 4 424624 AB032947 Hs. 151301 Ca2, dependent activator protein for secr 6. 4 429250 H56585 Hs. 198308 tryptophan rich basic protein 6. 3 414245 BE148072 Hs. 75850 WAS protein family, member 1 6. 3 433447 U29195 Hs. 3281 neuronal pentraxin 11 6. 3 424922 BE386547 Hs. 217112 hypotheticalprotein MGC10825 6. 3 426919 AL041228 ELAV (embryonic lethal, abnormal vision, 6. 3 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAA1330 protein 6. 3 415669 NM005025 Hs. 78589 serine (or cysteine) proteinase inhibito 6. 2 449048 Z45051 Hs. 22920 similar to S68401 (cattle) glucose induc 6. 2 433929 A1375499 Hs. 27379 ESTs 6. 2 423346 A1267677 Hs. 127416 synaptojanin 1 6. 2 448148 NM 016578 Hs. 20509 HBVpXassociatedprotein-8 6. 2 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 6. 2 409731 AA125985 Hs. 56145 thymosin. beta, identified in neuroblast 6. 2 420608 BE548277 Hs. 103104 ESTs 6. 2 424085 NM_002914 Hs. 139226 replication factor C (activator 1) 2 (40 6. 2 422175 N79885 Hs. 6382 ESTs, Highly similar to T00391 hypotheti 6. 1 428845 AL157579 Hs. 153610 KIAA0751 gene product 6. 1 439274 AF086092 Hs. 48372 ESTs 6. 1 447499 AW262580 Hs. 147674 protocadhedn beta 16 6. 1 425977 R15138 Hs. 165570 Homo sapiens clone 25052 mRNA sequence 6. 1 453924 R49295 Hs. 24886 ESTs 6. 1 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 6. 1 420077 AW512260 Hs. 87767 ESTs 6. 1 431721 AB032996 Hs. 268044 KIAA1170 protein 6. 1 433701 AW445023 Hs. 15155 ESTs 6. 1 430968 AW972830 gb : EST384925 MAGE resequences, MAGL Homo 6. 1 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxylating ; 6. 1 456723 Z43902 Hs. 4748 adenylate cyclase activating polypeptide 6. 0 448681 AL109781 Hs. 21754 Homo sapiens mRNA full length insert cDN 6. 0 429900 AA460421 Hs. 30875 ESTs 6. 0 410909 AW898161 Hs. 53112 ESTs, ModeraelysimilartoALU8_HUMANA 6. 0 432281 AK001239 Hs. 274263 hypothetical protein FLJ10377 6. 0 448243 AW369771 Hs. 52620 integrin, beta 8 6. 0 416427 BE244050 Hs. 79307 Rac/Cdc42guanine exchange factor (GEF) 6. 0 419704 AA429104 Hs. 45057 ESTs 6. 0 436936 AL134451 Hs. 197478 ESTs 6. 0 428409 AW117207 Hs. 98523 ESTs 6. 0 433244 AB040943 Hs. 271285 KIAA1510 protein 6. 0 439772 AL365406 Hs. 10268 Homo sapiens mRNA full length insert cDN 6. 0 408096 BE250162 Hs. 83765 dihydrofolate reductase 6. 0 419929 U90268 Hs. 93810 cerebral cavernous malformations 1 6. 0

422544 AB018259 Hs. 118140 K) AA0716geneproduct 6. 0 413627 BE182082 Hs. 246973 ESTs 6. 0 419985 H66373 Hs. 5856 ESTs. Highly similar to bA393J16. 3 [H. sa 6. 0 410366 A1267589 Hs. 302689 hypothetica) protein 6. 0 429183 AB014604 Hs. 197955 KA0704 protein 5. 9 430188 AL049242 Hs. 234794 HomosapiensmRNA ; cDNADKFZp564B083 (fr 5. 9 441102 AA973905 intermediate filament protein syncoilin 5. 9 448533 AL119710 Hs. 21365 nucleosome assembly protein 1-like 3 5. 9 407182 AA312551 Hs. 230157 ESTs 5. 9 437372 AA323968 Hs. 283631 hypothetical protein DKFZp547G183 5. 9 433523 H29882 ESTs 5. 9 444165 AL137443 Hs. 10441 hypotheticalprotein FU11236 5. 9 424343 AW956360 Hs. 4748 adenyiatecydase activating poiypeptide 5. 9 420156 AW449258 Hs. 6187 ESTs 5. 9 422864 AA318323 Hs. 12827 gb : EST20390 Retina II Homo sapiens cDNA 5. 8 446727 AB011095 Hs. 16032 KiM0523protein 5. 8 448543 AW897741 Hs. 21380 HomosapiensmRNA ; cDNADKFZp586P1124 (f 5. 8 430132 AA204686 Hs. 234149 hypothetical protein FLJ20647 5. 8 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 5. 8 419629 AB020695 Hs. 91662 KIAAOBBB protein 5. 8 452279 AA286844 Hs. 61260 hypothetical protein FU13164 5. 8 407808 AA663559 Hs. 279789 histone deacetylase 3 5. 8 414737 A1160386 Hs. 125087 ESTs 5. 8 432154 Api701523 Hs. 112577 ESTs 5. 8 410099 AA081630 KIAA0036 gene product 5. 8 411379 Api816344 Hs. 12554 ESTs, Weakly similar to NPL4_HUMAN NUCLE 5. 8 440492 R39127 Hs. 21433 hypothetical protein DKFZp547J036 5. 7 424560 AA158727 Hs. 150555 protein predicted by clone 23733 5. 7 419498 AL036591 Hs. 20887 hypotheticalprotein FLJ10392 5. 7 436643 AA757626 Hs. 10941 ESTs, Weakly similar to IPP1_HUMAN PROTE 5. 7 416111 AA033813 Hs. 79018 chromatinassembiyfætor1, subunitA (5. 7 419088 AI538323 Hs. 52620 integrin, beta 8 5. 7 436109 AA922153 Hs. 132760 hypothetical protein MGC15729 5. 7 428588 F12101 Hs. 185701 HomosapiensmRNAhulilengthinsertcDN 5. 7 451752 AB032997 Hs. 26966 KA 1171 protein 5. 7 413492 D87470 Hs. 75400 KIAA0280 protein 5. 7 414683 S78296 Hs. 76888 hypothetical protein MGC12702 5. 6 418079 R40058 Hs. 6911 ESTs 5. 6 445873 AA250970 Hs. 251946 poly (A)-binding protein, cytoplamic 1-l 5. 6 437034 AA742643 gb : ny9lcO1. s1 NCI CGAP_GCB1 Homosapiens 5. 6 419544 A1909154 gb : QV-BT200-010499-007 BT200 Homo sapien 5. 6 452785 AL359942 Hs. 296434 erythroid differentiation and denucleati 5. 6 408081 AW451597 Hs. 167409 ESTs 5. 6 436887 AW953157 Hs. 193235 hypothe6cal protein DKFZp547D155 5. 6 413589 AW452631 Hs. 313803 ESTs, HighlysimilartoAF1578331noncl 5. 6 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 5. 6 433556 W56321 Hs. 111460 calcium/calmodulin-dependentproteinkin 5. 5 448299 AA497044 Hs. 20887 hypothetical protein FLJ 10392 5. 5 425154 Nom-001851 Hs. 154850 collagen, type IX, alpha 1 5. 5 447773 A1423930 Hs. 36790 ESTs, Weakly similar to putative p150 [H 5. 5 422421 AA325138 Hs. 235873 hypothetical protein FU22672 5. 5 453128 AW026516 Hs. 31791 acylphosphatase 2, muscle type 5. 5 453220 AB033089 Hs. 32452 Homo sapiens mRNA for KIAA1263 protein, 5. 5 440866 Api703103 Hs. 271360 hypothetical protein MGC16275 5. 4 428976 AL037824 Hs. 194695 ras homolog gene family, member 1 5. 4 419723 AL120193 Hs. 339810 longevity assurance (LAG1, S. cerevisiae 5. 4 452799 A1948829 Hs. 213786 ESTs 5. 4 429038 AL023513 Hs. 194766 seizueelatedgene6 (mouse)-like 5. 4 445255 Mot4841 Hs. 12477 synaptosomal-associated protein, 91 kDa 5. 4 424332 AA338919 Hs. 101615 ESTs 5. 4 440210 AW674562 Hs. 125296 ESTs 5. 4 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 5. 4 448935 AL078596 Hs. 22591 nuclear receptor subfamily 2, group E, m 5. 4 452786 R61362 Hs. 106642 ESTs. Weakly similar to T09052 hypotheb 5. 4 408790 AW580227 Hs. 47860 neurotrophic tyrosine kinase, receptor. 5. 4 423476 AL035633 Human DNA sequence from clone RP5-1 046G1 5. 4 448507 AL133109 Hs. 21333 Homo sapiens mRNA ; cDNA DKFZp566N1047 (f 5. 4 419683 AA248897 Hs. 48784 ESTs 5. 4 407728 AW071502 Hs. 175931 ESTs 5. 4 453313 BE005771 Hs. 153746 hypothetical protein FU22490 5. 4 422094 AF129535 Hs. 272027 F-box only protein 5 5. 4 452856 AF034799 Hs. 30881 protein tyrosinephosphatase. receptor t 5. 4 434792 AA649253 Hs. 132458 ESTs 5. 4 412190 R16180 Hs. 274461 ESTs 5. 3 425588 F07396 Hs. 46627 ESTs 5. 3 444190 A1878918 Hs. 10526 cysteine and glycine-rich protein 2 5. 3 429698 Api685086 Hs. 26339 ESTs, Weakly similar to S21348 probable 5. 3 424458 M29273 Hs. 1780 myelin associated glycoprotein 5. 3 446997 AA383439 Hs. 16758 Spir-1 protein 5. 3 427302 AA400540 Hs. 135282 Homo sapiens cDNA FW1 1554 hs, chne HE 5. 3 439607 BE540565 Hs. 159460 ESTs 5. 3 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 5. 3 410037 AB020725 Hs. 58009 KIAA0918 protein 5. 3

451407 AA131376 Hs. 343809 fibroblast growth factor 12B 5. 3 430287 AW182459 Hs. 125759 ESTs, Weakly similar to LEUS HUMAN LEUKE 5. 3 428784 Y12851 Hs. 193470 pudnergic receptor P2X, ligand-gated io 5-3 418512 AW498974 diacylglycerd kinase, zeta (104kD) 5. 3 435538 AB011540 Hs. 4930 low density lipoprotein receptor-related 5. 3 420285 AA258124 Hs. 293878 ESTs, ModeratelysimilartoZN91_HUMANZ 5. 2 407896 D76435 Hs. 41154 Dcfamilymember1 (odd-paiedDrosophi 5. 2 404819 NM002688' : Homo sapiens peanut (Drosophi 5. 2 426503 AA380153 gb : EST93093 Skin tumor I Homo sapiens cD 5. 2 405348 C7001664 : gil12698061ldbjlBAB21849. 1l (AB 5. 2 431552 Al815863 Hs. 259873 axonal transport of synaptic vesicles 5. 2 418677 S83308 Hs. 87224 SRY (sex determining region Yybox 5 5. 2 427250 R35941 Hs. 25418 ESTs 5. 2 428037 N47474 Hs. 89230 potassium intermediatelsmall conductance 5. 2 445740 T78281 Hs. 13226 Homosapiensclone25181 mRNAsequence 5. 2 430130 AL137311 Hs. 234074 Homo sapiens mRNA ; cDNA DKFZp761G02121 (5. 2 423869 BE409301 Hs. 134012 C1q-elated factor 5. 2 416220 N49776 Hs. 170994 hypothetical protein MGC10946 5. 2 457005 AJ007421 Hs. 172597 sal (Drosophila)-like 3 5. 1 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 5. 1 414372 AA143654 gb : zo65aO2. r1 Stratagene pancrea (93720 5. 1 410631 AA086469 Hs. 47171 ESTs 5. 1 414821 M63835 Hs. 77424 Fc fragment of IgG, high afEniq la, re 5. 1 420133 AA426117 Hs. 155543 ESTs 5. 1 453884 AA355925 Hs. 36232 KIAA0186 gene product 5. 1 414922 D00723 Hs. 77631 glycine cleavage system protein H (amino 5. 1 414727 BE466904 Hs. 190162 gb : hz28fO3. x1 NCl_CGAP_GC6Homosapiens 5. 1 441869 NM 003947 Hs. 8004 huntingtin-associated protein interactin 5. 1 437387 A1198874 Hs. 28847 AD026 protein 5. 0 400533 ENSP00000209376* : PRED65 protein (Fragmen 5. 0 430979 A1479755 Hs. 129010 ESTs 5. 0 448944 AB014605 Hs. 22599 atrophin-1 interacting protein l. activi 5. 0 444600 R41398 Hs. 6996 ESTs 5. 0 453785 Al368236 Hs. 283732 ESTs, Moderately similar to ALU1 HUMAN A 5. 0 428878 AA436884 Hs. 48926 ESTs 5. 0 444670 H58373 Hs. 332938 hypothetical protein MGC5370 5. 0 440471 AA886146 Hs. 307944 ESTs 5. 0 410434 AF051152 Hs. 63668 toll-like receptor 2 5. 0 441390 A1692560 Hs. 131175 ESTs 4. 9 448765 R15337 Hs. 21958 Homo sapiens mRNA ; cDNA DKFZp547D086 (fr 4. 9 422263 AA307639 Hs. 129908 KIAA0591 protein 4. 9 431117 AF003522 Hs. 250500 delta (Drosophila)-like 1 4. 9 407235 D20569 Hs. 169407 SAC2 (suppessor of æUn mutations 2, y 4. 9 417404 NM007350 Hs. 82101 pleckstrinhomology-likedomain, family 4. 9 448548 R13209 Hs. 21413 solutecamerfamily12, (ptasium-chl 4. 9 420092 AA814043 Hs. 88045 ESTs 4. 9 449571 AW016812 Hs. 200266 ESTs 4. 9 412811 H06382 ESTs 4. 9 409100 H98216 Hs. 42245 ESTs, Moderately similar to 138022 hypot 4. 9 403142 NM002706' : Homo sapiens protein phosphat 4. 9 414300 A1304870 Hs. 188680 ESTs 4. 9 436607 AW661783 Hs. 211061 ESTs 4. 9 431553 X78075 Hs. 2799 cartilage linking protein 1 4. 9 449328 A1962493 Hs. 345303 ESTs 4. 9 420805 L10333 Hs. 99947 re6culon 1 4. 9 421688 AK000307 Hs. 106825 hypothetical protein FLJ20300 4. 9 452898 AA814497 Hs. 78792 ESTs 4. 9 427958 AA418000 Hs. 98280 potassium intermediate/small conductance 4. 9 432328 A1572739 Hs. 195471 6-phosphofructo-2-kinaselfructose-2, 6-bi 4. 9 408453 A1369838 Hs. 45127 chondroitin sulfate proteoglycan 5 (neur 4. 8 428841 A1418430 Hs. 104935 ESTs 4. 8 416439 AA180363 Hs. 118769 ESTs 4. 8 447458 A1741082 Hs. 158961 ESTs 4. 8 429433 AA452899 Hs. 213586 ESTs. Weakly similar to KIAA1353 protein 4. 8 409746 NM 004794 Hs. 56294 RAB33A, member RAS oncogene family 4. 8 436511 AA721252 Hs. 291502 ESTs 4. 8 443392 A1055821 Hs. 293420 ESTs 4. 8 423600 A1633559 Hs. 310359 ESTs 4. 8 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring finge 4. 8 414706 AW340125 Hs. 76989 KIAA0097 gene product 4. 8 407385 AA610150 Hs. 272072 ESTs. Weakly similar to 138022 hypothe6 4. 8 439340 AB032436 Hs. 6535 brain-specific Na-dependent inorganic ph 4. 7 427624 AA406245 Hs. 24895 ESTs 4. 7 413248 T64858 Hs. 21433 hypothetical protein DKFZp547J036 4. 7 408670 AF160967 Hs. 46784 potassium large conductance calcium-acti 4. 7 440491 R35252 Hs. 130558 ESTs, Weakly similar to 2109260AB cell 4. 7 411555 AF113537 Hs. 70669 HMP19 protein 4. 7 430471 AF064845 Hs. 241523 hypothetical protein F,10142 4. 7 413530 AA130158 Hs. 19977 ESTs, Moderately similar to ALU8 HUMAN A 4. 7 445900 AF070526 Hs. 125036 Homo sapiens clone 24787 mRNA sequence 4. 7 426457 AW894667 Hs. 169965 chimehn (chimaerin) 1 4. 7 459527 AW977556 Hs. 291735 ESTs, Weakly similar to 178885 sehnefth 4, 7 453096 AW294631 Hs. 11325 ESTs 4. 7

409125 R17268 Hs. 343567 axonal transport of synapticvesides 4. 7 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 4. 7 410276 A1554545 Hs. 68301 angiopoietin-2 4. 7 421637 AF035290 Hs. 106300 Homo sapiens clone 23556 mRNA sequence 4. 7 421633 AF121860 Hs. 106260 sorting nexin 10 4. 7 440052 A1633744 Hs. 195648 ESTs, Weakly similar to 138022 hyplheti 4. 7 439566 AF086387 gb : Homo sapiens full length insert cDNA 4. 7 432890 NM_014442 Hs. 279751 static acid binding ig-like iecUn 8 4. 6 402145 Target Exon 4. 6 409892 AW956113 Hs. 7149 gb : EST368183 MAGE resequences, MAGD Homo 4. 6 458760 A1498631 Hs. 111334 ferciGn, lightpolypeptide 4. 6 453362 H14988 Hs. 107375 ESTs 4. 6 436734 A1937612 Hs. 273758 hypotheticalprotein FU23112 4. 6 426925 NM001196 Hs. 315689 Homo sapiens cDNA : FW22373 fis, clone H 4. 6 409041 AB033025 Hs. 50081 Hypotheticaprotein, XP_051860 (KIM119 4. 6 428832 AA578229 Hs. 324239 ESTs, Moderately similar to ZN91_HUMAN Z 4. 6 423770 AW976766 Hs. 132776 Homo sapiens cDNA FU 10077 fis, clone HE 4. 6 410264 AK001853 Hs. 61508 HomosapienscDNAFLJ10991fis, clonePL 4. 6 429149 AW193360 Hs. 197962 ESTs, Weakly similar to 138022 hypothec 4. 6 437762 T78028 Hs. 154679 synaptotagmin 1 4. 6 439249 AF086060 Hs. 170053 G-protein coupled receptor 88 4. 6 416426 AA180256 Hs. 210473 Homo sapiens cDNA FW 14872 fis, clone PL 4. 6 425256 BE297611 Hs. 155392 collapsin response mediator protein 1 4. 6 415257 F03016 Hs. 27513 ESTs 4. 6 428186 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 4. 6 458814 A1498957 Hs. 170861 ESTS, Weakly similar to Z195_HUMAN ZINC 4. 6 451320 AW118072 diacylglycerol kinase, zeta (104kD) 4. 5 424998 U58515 Hs. 154138 chitinase 3-like 2 4. 5 422709 AA315331 Hs. 153485 ESTs 4. 5 420578 AA813546 Hs. 99034 GTP-binding protein Rho7 4. 5 421977 W94197 Hs. 1 10165 dbosomal protein L26 homolog 4. 5 457465 AW301344 Hs. 122908 DNA replication factor 4. 5 427712 A1368024 Hs. 283696 ESTs 4. 5 444656 A1277924 Hs. 145199 ESTs 4. 5 413409 AI638418 Hs. 1440 DEADIH (Asp-Glu-Ala-Asp/His) box polypep 4. 5 429399 AA452244 Hs. 16727 ESTs 4. 5 450639 A1703186 Hs. 277174 ESTs 4. 5 452106 Al141031 Hs. 21342 ESTs 4. 5 424240 AB023185 Hs. 143535 calcium/calmodulin-dependent protein kin 4. 5 433009 AA761668 gb : nz24cO8. s1 NCI CGAP GCB1 Homo sapiens 4. 5 446657 Al335191 Hs. 260702 ESTs, Weakly similar to 2109260A B cell 4. 5 428189 AA424030 Hs. 46627 ESTs 4. 5 423178 A1033140 Hs. 124983 Homo sapiens mRNA ; cDNA DKFZp564C142 (fr 4. 5 445133 AW157646 Hs. 198689 ESTs 4. 5 418771 AA807881 Hs. 25329 ESTs 4. 4 438456 AA913381 Hs. 20594 ESTs 4. 4 410386 W26187 Hs. 3327 HomosapienscDNA : FLJ22219 fis, clone H 4. 4 413834 BE296896 Hs. 224179 ESTs, Weakly similar to 138022 hypotheti 4. 4 419103 Z40229 Hs. 96423 hypotheGcal protein FLJ23033 4. 4 420560 AW207748 Hs. 59115 ESTs 4. 4 439662 H97552 Hs. 269060 ESTs 4. 4 408577 H50572 Hs. 19515 ESTs, HighlysimilartoNRG3_HUMANPRAN 4. 4 445034 AW293376 Hs. 143659 ESTs 4. 4 402605 Target Exon 4. 4 426271 AF026547 Hs. 169047 chondroiUn sulfate proteoglycan 3 (neur 4. 4 457561 AA331517 Hs. 286055 chimerin (chimaerin) 2 4. 4 430676 AF084866 gb : Homo sapiens envelope protein RIC-3 (4. 4 439570 T79925 Hs. 269165 ESTs, Weakly similar to ALU1HUMANALUS 4. 4 452752 AW044058 Hs. 33578 KIAA0820 protein 4. 4 439108 AW163034 Hs. 6467 synaptogyrin 3 4. 4 405819 NM002578 : Homosapiensp21 (CDKN1A)-æti 4. 4 446544 A1631932 Hs. 7047 ESTs, Weakly similar to Unknown [H. sapie 4. 4 412530 AA766268 Hs. 266273 hypothetical protein FW13346 4. 4 420871 AA702972 Hs. 65300 ESTs 4. 4 408622 AA056060 Hs. 202577 Homo sapiens cDNA FU 12166 fis, clone MA 4. 4 429269 AA449013 Hs. 99203 ESTs 4. 3 427463 AA442224 Hs. 97900 ESTs 4. 3 425402 A1215881 Hs. 24970 ESTs, Weakly similar to B34323 GTP-bindi 4. 3 412046 Y07847 Hs. 73088 RAS-related on chromsome 22 4. 3 427194 AA399018 Hs. 250835 ESTs 4. 3 437834 AA769294 Hs. 283854 gb : nz36gO3. s1 NCI_CGAP_GCB1 Homo sapiens 4. 3 409172 Z99399 Hs. 122593 ESTs 4. 3 409953 AA332277 Hs. 57691 cadherin 18, type 2 4. 3 426968 U07616 Hs. 173034 amphiphysin (Stiff-Mann syndrome with br 4. 3 452092 BE245374 Hs27842 hypothetical protein FLJ11210 4. 3 438458 AW975186 gb : EST387294 MAGE resequences, MAGN Homo 4. 3 446936 H10207 Hs. 47314 ESTs 4. 3 433932 AW954599 Hs. 169330 neuronal protein 4. 3 424800 AL035588 Hs. 153203 MyoD family inhibitor 4. 3 421988 AW450481 Hs. 161333 ESTs 4. 3 442832 AW206560 Hs. 253569 ESTs 4. 3 416586 D44643 Hs. 14144 secreted modular calcium-binding protein 4. 2 408369 R38438 Hs. 182575 solutecarnerfamily15 (H ? ? ? transport 4. 2

450530 NM 006668 Hs. 25121 cytochrome P450, subfamily 46 (cholester 4. 2 449318 AW236021 Hs. 78531 Homo sapiens. Similar to RIKEN cDNA 5730 4. 2 438624 AA889055 Hs. 123468 ESTs 4. 2 421027 AA761198 Hs. 55254 ESTs 4. 2 417632 R20855 Hs. 5422 glycoprotein M6B 4. 2 419412 AW161058 Hs. 90297 synuclein, beta 4. 2 430228 AW950939 Hs. 6382 ESTs, Highly similar to T00391 hypotheti 4. 2 450813 A1739625 Hs. 203376 ESTs 4. 2 412505 AA974491 Hs. 21734 ESTs 4. 2 440168 AA868507 Hs. 126141 ESTs 4. 2 441707 R42637 Hs. 21963 hypothetical protein DKFZp761B0514 4. 2 438703 A1803373 Hs. 31599 ESTs 4. 2 444127 N63620 Hs. 13281 ESTs 4. 2 447397 BE247676 Hs. 18442 E-1 enzyme 4. 2 445523 Z30118 Hs. 293788 ESTs, Moderately similar to unnamed prot 4. 2 415079 R43179 Hs. 22895 hypothetical protein FU23548 4. 2 416871 H98716 gb : yx13d08. s1 Soares melanocyte 2NbHM Ho 4. 2 408838 A1669535 Hs. 40369 ESTs 4. 2 425287 R88249 Hs. 155524 peanut (Drosophila)-like 2 4. 2 404584 Target Exon 4. 2 436035 AA703679 Hs. 106999 ESTs, Weakly similar to SYT5_HUMAN SYNAP 4. 2 409091 AW970386 Hs. 269423 ESTs 4. 2 437117 AL049256 Hs. 122593 ESTs 4. 2 429643 AA455889 Hs. 167279 FYVE-finger-containing RabS effector pro 4. 2 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 4. 2 408177 A1241733 Hs. 43871 ESTs 4. 2 438875 AA827640 Hs. 189059 ESTs 4. 2 447877 A1435184 Hs. 164252 ESTs 4. 2 415402 AA164687 Hs. 177576 mannosyl (alpha-1, 3-)-glycoprotein beta-4. 2 434859 BE255080 Hs. 299315 collapsin response mediator protein-5 ; C 4. 2 449714 AB033015 Hs. 23941 K) AA1189 protein 4. 2 427315 AA179949 Hs. 175563 Homo sapiens mRNA ; cDNADKFZp564N0763 (f 4. 2 404541 NM 030795 : Homo sapiens stathmin-like 4 (4. 1 449969 AW295142 Hs. 180187 Homo sapiens cDNA FW 14337 hs, clone PL 4. 1 422374 AW732869 Hs. 1519 protein kinase, cAMP-dependenL regulato 4. 1 422253 W81526 Hs. 118329 ESTs. ModeratelysimilartoGAD HUMANGA 4. 1 440483 A1200836 Hs. 150386 ESTs 4. 1 429421 AL031658 Human DNA sequence from clone RP1-310013 4. 1 432882 NM 013257 Hs. 279696 senum/glucocortcoid regulated kinase-li 4. 1 424001 W67883 Hs. 137476 paternally expressed 10 4. 1 422170 Api791949 Hs. 112432 anti-Mullerian hormone 4. 1 445292 AV653264 Hs. 13982 Homo sapiens cDNA FU 14666 fis, clone NT 4. 1 450407 NM 000810 Hs. 24969 gamma-aminobutyric acid (GABA) A recepto 4. 1 429401 AW296102 Hs. 99272 ESTs, Weakly similar to S32567 A4 protei 4. 1 408950 AA707814 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 4. 1 415796 R87548 Hs. 78854 ATPase, Na ? transporting, beta 2 polypep 4. 1 446619 AU076643 Hs. 313 secreted phosphoprotein t (osteopontin, 4. 1 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 4. 1 416547 H62914 Hs. 268946 ESTs, Weakly similar to PC4259 fem6n 4. 1 412777 A1335773 Hs. 270123 ESTs 4. 1 445225 A1216555 Hs. 202398 ESTs 4. 1 408926 AF217525 Hs. 49002 Down syndrome cell adhesion molecule 4. 1 417873 BE266659 Hs. 293659 Homosapiens, SimilartoRIKENcDNAA430 4. 1 443301 Ai733614 Hs. 220587 ESTs, Moderately similar to ALUS HUMAN A 4. 1 429281 AA830856 Hs. 29808 HomosapienscDNA : FLJ21122 fis, clone C 4. 1 448966 AW372914 Hs. 86149 phosphoinositol 3phosphate-binding prot 4. 1 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 4. 1 417355 D13168 Hs. 82002 endothelin receptor type 6 4. 1 410359 R38624 Hs. 106313 ESTs 4. 1 426529 AF090100 Hs. 170241 Homo sapiens clone IMAGE 23915 4. 1 433323 AA805132 Hs. 159142 ESTs 4. 1 434933 R91095 Hs. 4276 KIAA1701 protein 4. 1 453331 Al240665 ESTs 4. 1 422661 NM014700 Hs. 119004 KIAA0665 gene product 4. 1 424726 AK001007 Hs. 138760 Homo sapiens cDNA FLJ10145 fis, clone HE 4. 0 416805 F13271 Hs. 79981 Human clone 23560 mRNA sequence 4. 0 441797 Al936933 Hs. 214635 ESTs 4. 0 424282 R76421 Hs. 135694 ESTs 4. 0 407792 A1077715 Hs. 39384 putative secreted ligand homologous to t 4. 0 425390 A1092634 Hs. 156114 protein tyrosine phosphatase, non-recept 4. 0 435312 AJ243396 Hs. 4865 voltage-gatedsodiumchannelbeta-3subu 4. 0 424635 AA420687 Hs. 115455 HomosapienscDNAFW14259hs, cionePL 4. 0 423279 AW959861 Hs. 290943 ESTs 4. 0 444001 A1095087 Hs. 152299 ESTs, Moderately similar to S65657 alpha 4. 0 410768 AF038185 Hs. 66187 Homo sapiens clone 23700 mRNA sequence 4. 0 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 4. 0 450581 AF081513 Hs. 25195 TGF-beta4 4. 0 435854 AJ278120 Hs. 4996 putative ankyrin-repeat containing prote 4. 0 433615 AA732982 Hs. 269607 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 0 432058 AW665996 Hs. 130729 ESTs, Weakly similar to ALU1_HUMAN ALU S 4. 0 439774 AL360257 Hs. 213493 Homo sapiens mRNA full length insert cDN 4. 0 445666 R59960 Hs. 282386 ESTs 4. 0 450582 AI339732 G-rich RNA sequence binding factor 1 4. 0

437814 A1088192 Hs. 135474 ESTs, Weakly similar to DDX9_HUMAN ATP-D 4. 0 451468 AW503398 Hs. 293663 ESTs, Moderately similar to 138022 hypot 4. 0 449277 AA001064 Hs. 43670 ESTs 4. 0 440553 AA889416 Hs. 344043 Homo sapiens CDNA FU14459 fis, clone HE 4. 0 445888 AF070564 Hs. 13415 Homo sapiens clone 24571 mRNA sequence 4. 0 420111 AA255652 gb : zs21h11. r1 NCI CGAP_GCB1 Homosapiens 4. 0 407198 H91679 gb : yv04a07. s1 Soares fetal liver spleen 4. 0 422564 A1148006 Hs. 222120 ESTs 4. 0 443992 AW022228 Hs. 322922 ESTs 4. 0 435542 AA687376 ESTs 4. 0 444153 AK001610 Hs. 10414 hypothetical protein FU10748 4. 0 437748 AF234882 Hs. 5814 suppression of tumorigenicity 7 4. 0 439285 AL133916 hypothetical protein FW20093 4. 0 449655 A1021987 Hs. 59970 ESTs 4. 0 458435 A1418718 Hs. 144121 ESTs, Weakly similar to T46916 hypotheti 4. 0 412659 AW753865 Hs. 74376 olfactomedin related ER localized protei 4. 0 423905 AW579960 Hs. 135150 lung type-I cell membrane-associated gly 4. 0 432683 AW995441 Hs. 10475 ESTs 4. 0 410765 AI694972 Hs. 66180 nucieosomeassemblypnotein1-ike2 4. 0 420649 AI866964 Hs. 124704 ESTs, Moderately similar to S65657 alpha 4. 0 450927 A1807804 Hs. 134342. TASP for testis-specific adriamycin sens 4. 0 448985 AA324885 Hs. 22777 carbonic anhydrase XI 4. 0 416406 D86961 Hs. 79299 lipomaHMGICfusionpartner-ike2 4, 0 412754 AW160375 Hs. 74565 amyloid beta (A4) precursor-like protein 3. 9 416340 N31772 Hs. 79226 fasciculation and elongation protein zet 3. 9 428862 NM 000346 Hs. 2316 SRY (sex determining region Y)-box 9 (ca 3. 9 413554 AA319146 Hs. 75426 secretogranin 11 (chromogranin C) 3. 9 419687 A1638859 Hs. 227699 ESTs, Weakly similar to T2D3_HUMAN TRANS 3. 9 453438 A1469935 Hs. 22792 ESTs 3. 9 410082 AA081594 Hs. 158311 Musashi (Drosophila) homolog 1 3. 9 424736 AF230877 Hs. 152701 microtubule-interacting protein that ass 3. 9 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 3. 9 411666 AF106564 Hs. 71346 neurofilament 3 (150kD medium) 3. 9 439935 S75105 Hs. 8358 glutamate receptor, ionotropic, kainate 3. 9 459278 AW294659 Hs. 34054 Homo sapiens cDNA : FLJ22488 fis, clone H 3. 9 432809 AA565509 Hs. 131703 ESTs 3. 9 450568 AL050078 Hs. 25159 Homo sapiens cDNA FW 10784 hs, clone NT 3. 9 413951 AW051200 Hs. 75640 natriureticpeptide precursor A 3. 9 435743 T66861 Hs. 12962 ESTs 39 447937 AL109716 Hs. 20034 Homo sapiens mRNA full length insert cDN 3. 9 417576 AA339449 Hs. 82285 phosphoribosylglycinamide formyltransfer 3. 9 448526 AB028946 Hs. 21361 KIAA1023 protein 3. 9 445890 AF055019 Hs. 21906 Homosapiensclone24670mRNAsequence 3. 9 425241 AA324624 Hs. 155247 a'dolase C, fructose-bisphosphate 3. 8 417333 AL157545 Hs. 173179 bromodomain and PHDfingercontaining, 3 3. 8 435832 AA425688 Hs. 41641 Bruno (Drosophila)-like 4, RNA binding 3. 8 410592 R94088 Hs. 43569 ESTs 3. 8 443361 A1792628 Hs. 133273 ESTs 3. 8 403696 C4001100-: gij58523421gbjMD54015. 1l (AFO 3. 8 437756 AA767537 Hs. 197096 ESTs 3. 8 433675 AW977653 Hs. 75319 ribonucleotide reductase M2 polypepGde 3. 8 414998 NM_002543 Hs. 77729 oxidised low density lipoprotein (lectin 3. 8 425652 AB021742 Hs. 322431 neurogenic differentiation 2 3. 8 437449 AL390153 Hs. 208339 Homo sapiens mRNA ; cDNADKFZp762G113 (fr 3. 8 421040 AA715026 Hs. 135280 ESTs 3. 8 454171 AW854832 gb : QV2-CT0261-201099-011-f05 CT0261 Homo 3. 8 443740 R56434 Hs. 21062 ESTs 3. 8 441668 A1611973 Hs. 136313 ESTs 3. 8 423175 W27595 Hs. 347310 hypothetical protein FU14627 3. 8 457183 H91882 Hs. 118569 Dvl-bindingproteinlDAX (inhibiúonof 3. 8 438142 T90309 Hs. 269651 ESTs 3. 8 408875 NM015434 Hs. 48604 DKFZP434B168 protein 3. 8 436899 AA764852 Hs. 291567 ESTs 3. 8 456497 AW967956 Hs. 123648 ESTs, WeaklysimilartoAF1084601ubinu 3. 8 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 3. 8 413199 M62843 Hs. 75236 ELAV (embryonic lethal, abnormal vision, 3. 8 410711 AB002316 Hs. 65746 KlM0318protein 3. 8 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 3. 8 438944 AA302517 Hs. 92732 KIM1444 protein 3. 8 445078 AI869975 Hs. 4775 junctophilin 3 3. 8 424330 AW073953 Hs. 333396 Homo sapiens cDNA FW13596 hs, clone PL 3. 8 439099 AB037800 Hs. 6462 protein kinase C and casein kinase subst 3. 8 449444 AW818436 Hs. 23590 solutecarierfamily16 (monocaboxylic 3. 8 411252 AB018549 Hs. 69328 MD-2 protein 3. 7 448275 BE514434 Hs. 20830 kinesin-like 2 3. 7 434269 AK001991 Hs. 3781 similar to murine leucine-rich repeat pr 3. 7 400777 NM007325' : Homo sapiens glutamate recept 3. 7 419586 A1088485 Hs. 144759 ESTs, Weakly similar to 138022 hyphe6 3. 7 458072 Al890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 3. 7 445908 R13580 Hs. 13436 Homo sapiens clone 24425 mRNA sequence 3. 7 448451 AW015994 Hs. 345433 gb : UI-H-BIOp-abh-g-O9-0-Ul. s1 NCI CGAP_S 3. 7 430183 BE010038 gb : PM3-BN017M00400-001-g04BN0176Homo 3. 7 430147 R60704 Hs. 234434 hairy/enhancer-of-split related with YRP 3. 7

458912 A1911066 ESTs 3. 7 428110 A1312485 Hs. 138294 ESTs, Moderately similar to Z195_HUMAN Z 3. 7 448048 BE281291 Hs. 170408 ESTs, Moderately similar to A47582 B-cel 3. 7 442326 H92962 Hs. 124813 hypothetical protein MGC14817 3. 7 422798 R92347 Hs. 34574 ESTs, Weakly similar to ALU 1 HUMAN ALU S 3. 7 428873 A1701609 Hs. 98908 ESTs 3. 7 438208 AL041224 Hs. 65379 ESTs 3-7 414040 N58513 Hs. 32171 ESTs 3. 7 407846 AA426202 Hs. 40403 Cbp/p300-interacting transacGvator, wit 3. 7 408829 NM_006042 Hs. 48384 heparan sulfate (glucosamine) 3-0-sulfot 3. 7 425010 T16837 Hs. 4241 ESTs 3. 7 427209 H06509 Hs. 92423 KIAA1566 protein 3. 7 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, 3. 6 410126 BE169274 KIAA0036geneproduct 3. 6 426646 AA382787 Hs. 122713 ESTs 3. 6 418329 AW247430 Hs. 84152 cystathionine-beta-synthase 3. 6 419390 A1701162 Hs. 90207 hypothetical protein MGC11138 3. 6 441703 AW390054 Hs. 192843 leucine zipper protein FKSG14 3. 6 431725 X65724 Hs. 2839 Norde disease (pseudoglioma) 3. 6 448425 A1500359 Hs. 346112 ESTs 3. 6 423611 AB011163 Hs. 129908 KIAA0591 protein 3. 6 438831 BE263273 Hs. 6439 synapsin 11 3. 6 419235 AW470411 Hs. 288433 neurotnmin 3. 6 451027 AW519204 Hs. 40808 ESTs 3. 6 428483 A1908539 Hs. 184592 KlM0344geneproduct 3. 6 424947 R77952 ESTs, Weakly similar to alternatively sp 3. 6 404150 Target Exon 3. 6 450297 AW901347 Hs. 38592 hypothetical protein FU23342 3. 6 443715 A1583187 Hs. 9700 cyclin Ei 3. 6 435910 A1084152 Hs. 21782 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 6 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 3. 6 432488 AA551010 Hs. 216640 ESTs 3. 6 431342 AW971018 Hs. 21659 ESTs 3. 6 437916 BE566249 Hs. 20999 hypothetical protein FU23142 3. 6 412043 BE156622 Hs. 333371 Homo sapiens clone TA40 untranslated mRN 3. 6 448448 NM 014954 Hs. 21239 KIAA0985 protein 3. 6 447818 W79940 Hs. 21906 Homo sapiens clone 24670 mRNA sequence 3. 6 445105 AF238869 Hs. 283955 HomosapienscbneGLSH-2similarUgti 3. 6 409557 BE182896 Hs. 211193 ESTs 3. 6 425202 AW962282 Hs. 152049 ESTs, Weakly similar to 138022 hypotheti 3. 6 451734 NM006176 Hs. 26944 neurogranin (protein kinase C substrate, 3. 6 425331 AW962128 gb : EST374201 MAGE resequences, MAGG Homo 3. 6 412799 A1267606 gb : aq91hO3. x1 Stanley Frontal SB pool 1 3. 6 435040 A1932350 Hs. 152825 ESTs 3. 6 434149 Z43829 Hs. 244624 hypothetical protein MGC5469 3. 6 415709 AA649850 Hs. 278558 ESTs 3. 6 424051 AL110203 Hs. 138411 HomosapiensmRNA ; cDNADKFZp586J1922 (f 3. 6 437640 AA764893 Hs. 272155 ESTs, Weakly similar to 138022 hypotheti 3. 6 445953 A1612775 Hs. 145710 ESTs 3. 6 449256 AA059050 Hs. 59847 ESTs 3. 6 424687 J05070 Hs. 151738 matrixmetalloproteinae9 (gelatinaeB 3. 6 409327 L41162 Hs. 53563 collagen, type IX, alpha 3 3. 6 417675 A1808607 Hs. 3781 similar to murineieucine-nch repeat pr 3. 6 423641 AL137256 Hs. 130489 ATPase, aminophospholipidtransporter-li 3. 6 443912 R37257 Hs. 184780 ESTs 3. 6 424572 M19650 Z, 3-cyclic nucleotide 3'phosphodieste 3. 5 424899 AL119387 Hs. 119062 ESTs 3. 5 439726 AW449893 Hs. 293707 ESTs, Weakly similar to 138598 zinc ting 3. 5 41. 6490 AF090116 Hs. 79348 egulatorofGproteinsigna'ling7 3, 5 458809 AW972512 Hs. 20985 sin3-associated polypeptide, 30kD 3. 5 429084 AJ001443 Hs. 195614 splicing factor 3b, subunit 3, 130kD 3. 5 407624 AW157431 Hs. 248941 ESTs 3 5 419038 AW134924 Hs. 190325 ESTs 3 5 451489 NM_005503 Hs. 26468 amytoid beta (A4) precursor protein-bind 3. 5 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 3. 5 411048 AK001742 Hs. 67991 hypothetical protein DKFZp434G0522 3. 5 435575 AF213457 Hs. 44234 triggering receptor expressed on myeloid 3. 5 424340 AA339036 Hs. 7033 ESTs 3. 5 425790 AW136286 Hs. 288446 ESTs 3. 5 432188 A1362952 Hs. 2928 solutecarierfamily7 (cationicamino 3. 5 453896 AW293483 Hs. 255205 KIAA1853 protein 3. 5 434784 AA649051 Hs. 164007 ESTs 3. 5 452449 AW068658 Hs. 20943 ESTs 3. 5 425212 AW962253 Hs. 171618 ESTs 3. 5 407253 AA411175 Hs. 141939 ESTs, Moderately similar to S65657 alpha 3. 5 418049 AA211467 Hs. 190488 Homosapiens, Similartonuclearlocaliz 3. 5 421247 BE391727 Hs. 102910 general transcription factor IIH, polype 3. 5 459311 R40192 Hs. 21527 Human DNA sequence from clone GS1-115M3 3. 5 439450 R51613 Hs. 125304 ESTs 3. 5 435545 AA687415 Hs. 28107 ESTs 3. 5 445729 H21066 Hs. 13223 Homo sapiens mRNA full length insert cDN 3. 5 448999 AF179274 Hs. 22791 transmembrane protein with EGF-like and 3. 5 412590 AL134388 Hs. 135033 ESTs, Weakly similar to 138022 hypotheti 3. 5

438527 A1969251 Hs. 115325 RAB7, member RAS oncogene family-like 1 3. 5 441111 A1806867 Hs. 126594 ESTs 3. 5 418630 Api351311 Hs. 251946 poly (A)-binding protein, cytoplasmic 1-1 3. 5 439920 H05430 Hs. 288433 neurotrimin 3. 5 421268 A1126821 Hs. 30514 ESTs 3. 5 432022 AL162042 Hs. 272348 Homo sapiens mRNA ; cDNADKFZp761L1212 (f 3. 5 412719 AW016610 Hs. 816 ESTs 3. 5 435092 AL137310 Hs. 4749 Homo sapiens mRNA ; cDNA DKFZp761E13121 (3. 5 414178 AW957372 Hs. 46791 ESTs, Weaklysimilartol38022hypothe6 35 437252 At433833 Hs. 164159 ESTs, Weakly similar to ALU 1-HUMAN ALU S 3. 5 452108 AW135982 Hs. 203013 hypothetical protein FLJ12748 3. 4 421183 AL135740 Hs. 102447 TSC-22-like 3. 4 441834 AL138034 Hs. 7979 KIAA0736 gene product 3. 4 413812 AW188687 Hs. 44748 ESTs 3. 4 449932 A1675444 Hs. 263024 ESTs 3. 4 447067 R42098 Hs. 21964 ESTs 3. 4 408296 AL117452 Hs. 44155 DKFZP586G1517 protein 3. 4 447028 AI973128 Hs. 167257 brain link protein-1 3. 4 432715 AA247152 Hs. 200483 ESTs, Weakly similar to KIAA1074 protein 3. 4 418358 L02840 Hs. 84244 potassium voltage-gated channel, Shab-re 3. 4 417084 H08370 Hs. 33067 ESTs 3. 4 444534 AW271626 Hs. 42294 ESTs 3. 4 440700 AW952281 Hs. 296184 guanine nucleotide binding protein (G pr 3. 4 436637 A1783629 Hs. 26766 ESTs 3. 4 412820 BE001236 gb : CM3 BNO075-240200-101411 BN0075 Homo 3. 4 428138 AA773842 Hs. 293799 ESTs 3. 4 453033 AA325869 Hs. 31463 KIAA0281 gene product 3. 4 453305 R39224 Hs. 267997 EHM2 gene 3. 4 459660 M79082 ESTs 3. 4 418821 AA436002 Hs. 183161 ESTs 3. 4 439518 W76326 gb : zd60dO4. ri Soaes_fetal_heart_NbHH19W 3. 4 400379 NM 018432 Homo sapiens ovarian cancer related prot 3. 4 437085 AA743935 Hs. 202329 ESTs 3. 4 419852 AW503756 Hs. 286184 hypothetical protein dJ551D2. 5 3. 4 430694 AA810624 Hs. 30936 ESTs, Weakly similar to H28H-HUMAN HISTO 3. 4 441287 AW293132 Hs. 131373 ESTs 3. 4 425870 R13406 Hs. 56782 ESTs 3. 4 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 3. 4 448044 AI458682 gb : tk13eO1. x1 NCl_CGAP_Lu24 Homo sapiens 3. 4 405238 Target Exon 3. 4 440404 A1015881 Hs. 324527 mitochondrial ribosomal protein S5 3. 4 453590 AF150278 Hs. 33578 KIAA0820 protein 3. 4 450756 A1733488 Hs. 144062 ESTs 3. 4 404283 ENSP00000244751' : Copine-like protein KIA 3. 4 423257 AW161039 Hs. 125878 synapsin 111 3. 4 432149 AW614326 Hs. 133483 ESTs, Weakly similar to T34549 probable 3. 4 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) 3. 4 422809 AK001379 Hs. 121028 hyplheticalproteinFW10549 3. 4 420050 AL118615 Hs. 94653 neurochondrin 3. 4 431789 H19500 Hs. 269222 mitogen-activated protein kinase 4 3. 4 408601 U47928 Hs. 86122 protein A 3. 4 453740 AL120295 Hs. 311809 ESTs, Moderately similar to PC4259 fem 3. 4 449919 A1674685 Hs. 200141 ESTs 3. 4 426380 A1291267 Hs. 149990 ESTs 3. 4 408554 AA836381 Hs. 315111 nuclearreceptorco-repressor/HDAC3comp 3. 3 443257 A1334040 Hs. 11614 HSPC065 protein 3. 3 432731 R31178 Hs. 287820 fibronectin 1 3. 3 421679 Al475110 Hs. 203933 ESTs 3. 3 453169 AB037815 Hs. 32156 KIAA1394 protein 3. 3 437397 AA349847 Hs. 4221 hypothetical protein DKFZp761H039 3. 3 443310 BE552018 Hs. 133152 ESTs 3. 3 423169 BE047009 Hs. 21837 ESTs, Weakly similar to KIAA0927 protein 3. 3 433657 A1244368 Hs. 8124 PH domain containing protein in retina 1 3. 3 408449 NM 004408 Hs. 166161 dynamin 1 3. 3 417402 BE503227 Hs. 134759 ESTs 3. 3 416677 T83470 Hs. 334840 ESTs, Moderately similar to 178885 serin 3. 3 439753 BE262233 Hs. 7423 hypothetical protein from EUROIMAGE 2168 3. 3 455646 BE064420 gb : RC4-BT0311-241199-012-c8 BT0311 Homo 3. 3 450337 A1693256 Hs. 202427 ESTs 3. 3 423420 A1571364 Hs. 128382 Homo sapiens mRNA : cDNA DKFZp76111 224 (f 3. 3 433236 NM004296 Hs. 3221 regulator of G-protein signalling 6 3. 3 417868 A1078534 Hs. 122592 ESTs 3. 3 436207 AA334774 Hs. 12845 hypothetical protein MGC13159 3. 3 441607 NM 005010 Hs. 7912 neuronal cell adhesion molecule 3. 3 449249 T52285 Hs. 193115 Homo sapiens mRNA for KIAA1764 protein, 3. 3 418216 AA662240 Hs. 283099 AF 1 5q 14 protein 3. 3 456060 C14904 Hs. 45184 Homo sapiens cDNA FW12284 hs, clone MA 3. 3 449145 A1632122 Hs. 198408 ESTs 3. 3 415101 R45531 Hs. 144534 ESTs 3. 3 401272 C9000559-: gil12314195lemblCAB99333. 1l (A 3, 3 420297 A1628272 Hs. 88323 ESTs, WeaklysimilarloALU1 HUMANALUS 3. 3 419991 AJ000098 Hs. 94210 eyesabsent (Drosophila) homolog1 3. 3 443761 A1525743 Hs. 345187 ESTs 3 3

427317 AB028955 Hs. 175780 KIAA1032 protein 3. 3 426920 AA393351 Hs. 132121 ESTs 3. 3 433894 A1907682 Hs. 243293 ESTs 3. 3 454253 AV660717 Hs. 47144 DKFZP586N0819 protein 3. 3 419647 AA348947 Hs. 91816 hypothetical protein 3. 3 439978 BE139460 Hs. 124673 HomosapienscDNAFW11477hs, cloneHE 3. 3 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-0-sulfot 3. 3 428670 AA431682 Hs. 134832 ESTs 3. 3 435375 A1733610 Hs. 187832 ESTs 3. 3 419043 T19167 Hs. 89566 ets variant gene 1 3. 3 403341 Target Exon 3. 3 436282 R91913 Hs. 272104 ESTs, Moderately similar to ALU1 HUMAN A 3. 3 439627 BE621702 Hs. 29076 hypothetical protein FU21841 3. 3 456209 W60633 Hs. 297792 ESTs 3. 3 438810 AW897846 Hs. 6421 hypothetical protein DKFZp761N09121 3. 3 411565 AW851728 gb : MR2-CT0222-011199-007d06 CT0222 Homo 3. 3 418203 X54942 Hs. 83758 CDC28 protein kinase 2 3. 3 451254 A1571016 Hs. 172967 ESTs 3. 3 435056 AW023337 Hs. 5422 glycoprotein M6B 3. 3 433842 A1652156 Hs. 26346 ESTs 3. 3 433325 AW206986 Hs. 143905 ESTs 3. 3 451066 A1758660 Hs. 206132 ESTs 3. 3 436114 AA778232 Hs. 19515 ESTs, HighlysimilartoNRG3_HUMANPRO-N 3. 3 421686 AB011156 Hs. 106794 KiM0584protein 3. 3 429228 A1553633 Hs. 326447 ESTs 3. 3 450325 A1935962 Hs. 26289 ESTs 3. 3 412350 A1659306 Hs. 73826 protein tyrosine phosphatase, non-recept 3. 3 451778 AI826131 Hs. 62954 ESTs, Weakly similar to zinc finger prot 3. 3 435977 AL138079 Hs. 5012 brain-specific membrane-anchored protein 3. 2 450475 AW805634 Hs. 205015 ESTs 3. 2 418661 NM 001949 Hs. 1189 E2F transcfipfion factor 3 3. 2 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel 3. 2 407332 A1801565 Hs. 200113 Homo sapiens cDNA FW11379 hs, clone HE 3. 2 415131 D61119 gb : HUM1 58C11 B Clontech human fetal brain 3. 2 409248 AB033035 Hs. 51965 K1AA1209 protein 3. 2 431462 AW583672 Hs. 256311 granin-like neuroendocrine peptide precu 3. 2 434834 AF156774 Hs. 324020 1-acylglycerol-3-phosphate 0-acyltransfe 3. 2 450358 AB010098 Hs. 24907 coronin, actin-binding protein, 2B 3. 2 438461 AW075485 Hs. 286049 phosphoserineaminotransferase 3. 2 405239 U89281 oxidative 3 alpha hydroxysteroid dehydro 3. 2 407304 AA565832 Hs. 271649 gb : nj32bO3. s1 NCI_CGAP_M1 Homo sapiens 3. 2 451697 AW449774 Hs. 296380 POM (POM121 rat homolog) and ZP3 fusion 3. 2 435071 D60683 Hs. 35495 ESTs 3. 2 420352 BE258835 gb : 601117374Ft NIH_MGC_16 Homo sapiens c 3. 2 412193 A1684467 Hs. 144057 ESTs 3. 2 442320 A1287817 Hs. 129636 ESTs 3. 2 407378 AA299264 Hs. 57776 ESTs, Moderately similar to 138022 hypot 3. 2 414528 AA148950 Hs. 188836 ESTs 3. 2 439764 T26535 Hs. 22744 hypothetical protein MGC13105 3. 2 410425 BE278367 Hs. 63510 KIAA0141 gene product 3. 2 429876 AB028977 Hs. 225974 KIAA1054 protein 3. 2 427627 R87582 Hs. 179915 guanine nucleotide binding protein (G pr 3. 2 439039 A1656707 Hs. 48713 ESTs 3. 2 447925 AW292271 Hs. 250718 ESTs 3. 2 447714 AW296313 Hs. 255537 ESTs 3. 2 434574 A1424458 Hs. 33470 ESTs 3. 2 437269 AA334384 Hs. 149420 ESTs 3. 2 416845 H95279 Hs. 293788 gb : yu20hO2. su Soaresfetaliverspleen 3. 2 452234 AW084176 Hs. 223296 ESTs, Weakly similar to 138022 hypotheb 3. 2 440274 R24595 Hs. 7122 scrapie responsive protein 1 3. 2 437698 R61837 Hs. 7990 ESTs, Moderately similar to 184505 calci 3. 2 414761 AU077228 Hs. 77256 enhancer of zeste (Drosophila) homolog 2 3. 2 445828 F05802 Hs. 81907 ESTs 3. 2 423779 AW071837 Hs. 57971 ESTs 3. 2 403790 NM001334' : Homo sapiens cathepsin 0 (CTS 3. 2 453792 AL134539 Hs. 254129 KIAA1678 3. 2 428167 AA770021 Hs. 16332 ESTs 3. 2 445413 AA151342 Hs. 12677 CGI-147 protein 3. 2 415314 N88802 Hs. 5422 glycoprotein M6B 3. 2 425115 R44664 Hs. 123956 ESTs 3. 2 432625 At243596 Hs. 94830 ESTs, Moderately similar to T03094 A-kin 3. 2 412420 AL035668 Hs. 73853 bone morphogenetic protein 2 3. 1 422772 AL119585 Hs. 120228 KIAA0749 protein 3. 1 437414 AW894071 Hs. 48448 hypthetical protein DKFZp547C176 3. 1 427961 AW293165 Hs. 143134 ESTs 3. 1 435256 AF193766 Hs. 13872 cytokine-like protein C17 3. 1 428966 AF059214 Hs. 194687 cholesterol25-hydroxylase 3. 1 413995 BE048146 Hs. 75671 syntaxin 1A (brain) 3. 1 443431 A1056847 Hs. 20654 ESTs 3. 1 414217 A1309298 Hs. 279898 Homo sapiens cDNA : FU23165 fis, clone L 3. 1 419617 AL008583 Hs. 91622 neuronal pentraxin receptor 3. 1 444326 A1939357 Hs. 270710 ESTs 3. 1 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 3. 1

446131 NM 000929 Hs. 290 phospholipaeA2, groupV 3. 1 423858 AL137326 Hs. 133483 Homo sapiens mRNA ; cDNA DKFZp434B0650 (f 3. 1 448475 BE613134 Hs. 247474 hypothe6cal protein FU21032 3. 1 432682 A1376400 Hs. 159588 ESTs 3. 1 450661 AW952160 Hs. 83849 ESTs 3. 1 417636 R08916 Hs. 191212 ESTs 3. 1 417918 AA209205 Hs. 163754 hypotheticalprotein FW12606 3. 1 454032 W31790 Hs. 194293 ESTs, Weakly similar to f54374 gene NF2 3. 1 443150 A1034467 Hs. 34650 ESTs 3. 1 404632 NM022490 : Homo sapiens hypothetical prot 3. 1 425537 AB007913 Hs. 158291 KIAA0444 protein 3. 1 437162 AW005505 Hs. 5464 thyroid hormone receptor coactivatingpr 3. 1 400090 Eos Control 3. 1 445424 AB028945 Hs. 12696 cortactin SH3 domain-binding protein 3. 1 422949 AA319435 gb : EST21657 Adrenal gland tumor Homo sap 3. 1 448750 U95020 Hs. 21903 calcium channel, voitagezdependent, beta 3. 1 433560 Al925195 Hs. 130891 hypthe6caiproteinMGC4400 3. 1 433042 AW193534 Hs. 281895 Homo sapiens DNA 11660fis. done HE 3. 1 449722 BE280074 Hs. 23960 cyclin B1 3. 1 425480 AB023198 Hs. 158135 KIAA0981 protein 3. 1 449670 F07693 Hs. 85603 Homo sapiens mRNA ; DNA DKFZp434K2172 (f 3. 1 452619 AW298597 Hs. 61884 Homo sapiens, clone IMAGE : 4298026, mRNA, 3. 1 428722 U76456 Hs. 190787 tissue inhibitorofmetatioproteinase 4 3. 1 405605 C2001342 : gil127814jsplP26434lNAH4_RAT SO 3. 1 417565 A1203405 Hs. 47831 ESTs 3. 1 439538 AA837323 Hs. 56407 ESTs 3. 1 414117 W88559 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 3. 1 430818 Ai311928 Hs. 348156 gb : qo89hO4. x1 NCl_CGAP_KdSHomosapiens 3. 1 408508 Ai806109 Hs. 135736 KIAA1580 protein 3. 1 414884 R54418 Hs. 183745 hypothetical protein FLJ13456 3. 1 439963 AW247529 Hs. 6793 platelet-ac6vabng factor acetylhydmia 3. 1 446636 AC002563 Hs. 15767 citron (rho-interacting. sedne/threonin 3. 1 417169 R13550 Hs. 246773 ESTs 3. 1 450202 AW969756 Hs. 34145 ESTs, Weakly similar to B49647 GTP-bindi 3. 1 428060 AA420616 Hs. 249483 ESTs 3. 1 430526 AF181862 Hs. 242407 G protein-coupled receptor, family C, gr 3. 1 421458 NM003654 Hs. 104576 carbohydrate (keratan sulfate Gal-6) sut 3. 1 429163 AA884766 gb : am20a10. s1 Soares_NFL_T_GBC_S1 Homo s 3. 0 428180 AI129767 Hs. 182874 guanine nucleotide binding protein (G pr 3. 0 422631 BE218919 Hs. 118793 hypothetical protein FU10688 3. 0 433290 R20077 Hs. 302185 Homo sapiens clone 23618 mRNA sequence 3. 0 412507 L36645 Hs. 73964 EphA4 3. 0 415827 H17462 Hs. 23079 ESTs 3. 0 429609 AF002246 Hs. 210863 cell adhesion molecule with homology to 3. 0 457358 A1479755 Hs. 129010 ESTs 3. 0 441732 AW298818 Hs. 127341 ESTs 3. 0 459318 Nom-000038 gb : Homo sapiens adenomatosis polyposis c 3. 0 426384 A1472078 Hs,303662 hypotheticalprotein FLJ13189 (FU13189) 3. 0 436267 AW450938 Hs. 180115 ESTs 3. 0 450650 T65617 Hs. 101257 hypothetical protein MGC3295 3. 0 414865 AA157155 Hs. 274414 hypothetical protein FU14457 3. 0 459080 AW192083 Hs. 290855 ESTs 3. 0 412783 BE276738 Hs. 74578 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 3. 0 432593 AW301003 Hs. 51483 ESTs, Weakly similar to hypothetical pro 3. 0 443753 AW367578 Hs. 134749 ESTs 3. 0 445921 AW015211 Hs. 146181 ESTs 3. 0 427695 R88483 Hs. 172862 ESTs 3. 0 438283 A1458931 Hs. 37282 ESTs 3. 0 453324 W26592 Hs. 232089 ESTs 3. 0 421094 AW978202 Hs. 289064 hypothetical protein FU22251 3. 0 433434 AA588429 gb : no22bO3. sl NCI CGAP Pr22 Homo sapiens 3. 0 452850 H23230 Hs. 22481 ESTs, Moderately similar to A46010 X-lin 3. 0 416658 U03272 Hs. 79432 fibdllin 2 (congenital contractural ara 3. 0 429569 AA454993 Hs. 138343 ESTs, Weakly similar to 178885 serine/th 3. 0 428600 AW863261 Hs. 242413 hypothetical protein DKFZp434K1421 3. 0 443633 AL031290 Hs. 9654 similar to pregnancy-associated plasma p 3. 0 433229 AB040925 Hs. 91625 KIAA1492 protein 3. 0 429046 X57436 Hs. 194772 oligodendrocyte myelin glycoprotein 3. 0 431431 AL096711 Hs. 252953 HumanDNAsequencefromcloneRP3-403A15 3. 0 414430 A1346201 Hs. 76118 ubiquifin carboxyl-tenninal esterase Ll 3. 0 423165 A1937547 Hs. 124915 hypothetical protein MGC2601 3. 0 440261 M81886 Hs. 7117 glutamate receptor, ionotropic, AMPA 1 3. 0 441364 AW450466 Hs. 126830 ESTs, WeaklysimilartoYD38_YEASTHYPOT 3. 0 437056 A1147061 gb : ok33a11. s1 Soares NSF FS 9W OT PA P S 3. 0 429168 AA984682 Hs. 146589 ESTs, Weakly similar to JC5238 galactosy 3. 0 453739 AL120266 ESTs 3. 0 TABLE 15B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession

410099 117647 1 AA081630 T08671 AI174254 D83874 AW959843 AA364503 AA693467 AW993370 BE327037 AA167714 N79906 AW901977 AW901980 W52882 T07735 AA484549 W60090 D52685 T23811 BE327043AW901768 BE551237 AA917004 AA716027 A1439658 M283724 A1805992A1457095 AA084618 BE467736 A1092635 AI887863 AI697593 AA436618 AIt67419 AI418634 T31586 AA436630 AA706191 A1041169 AI422304 T03534 AA211402 A1204899 A1366472 AW827081 AA788593 T32736 AI767935 AAt67791 AA747914 AA663870 AI865504 410126 1177611 BE169274 AW893230 AA210998 H24222 AA081774 BE000935 BE000834 AA334880 411565 1249756_1 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628 412799 132817_1 Al267606M121045M126521 412811 132943_1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 A1424991 A1693507 A1863108 AA599060 A1091148 AA598689 R39887 AA813482 AW016452 H06383 R41807 Al364263 M620528Ai241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734 412820 1330039 1 BE001236 BE00117 BE001180 BE001234 414372 143909 1 AA143654 AW753140 AA213770 AW970865 AA569075 AA492132 415131 1523680_1 D61119D81508D81734 416871 1626761_1 H98716 N90792 N24283 418512 176394_1 AW498974T09332R58460AA350990T33786T30936AA350905T08592T09274 AA224297D54678T08951 R15346AW953188AA350074 AW890649 419544 185760 2 A1909154 AA526337 AA244193 A1909153 420111 190755 1 AA255652 AA280911 AW967920 AA262684 420352 192979_1 BE258835 AW968316 M258918 AW843305 R14744 Al580388 BE071923 R36280 422949 2231841 AA319435 N56456 AA319377 AW961532 T48452 AA894424 423476 22861 1 AL035633 F11794 F11783 H18042 T66089 H29379 R19493 AW134660 AI299437 AL133995 AA057405 N78357 AA917450 A1002692 T09262 T65008 H29290 AI200874 AA894415 AI732887 AI791768 AI733447 AA988785 N62128 T09261 AW956936 424572 240971 M19650 R18810 R18721 AW896146 AW889520 AA192362 AA176814 F12085 BE255264 BE251393 T65248 AA380585 AA380465 BE408684 AA459037 AW498869 AA776107 BE274289 D45269 M61958 AA378818 AW663180 AW672958 H08611 M78164 BE393721 AA348660 R36303 AW498662 AA019090 AA001087 AA054302 AA01 9775 AA018808 AA019132 A1858240 R73218 H30477 H17776 AA659570 BE276750 AL118657 AA375861 AA352427 AW581695 AI141188 N63474 AA654162 H17659 AL120696 T28867 AW498868 A135591 8 AA902349 AA569098 A108823i A1042604 AA555133 AI183611 AI608822 AI275941 AW316805 AA349486 A1355233 R85117 AW613626 R49234 AA458846 N20669 H18693 M977567 T15423 AW002084 Al824721 N36242 AI417281 A1018212 AA912337 F09722 AA749449 AW879172 AA885427 AA916639 Api872560 F00482 H45184 AI217251 AA775807 BE39001 AA303517 AA001050 BE515169 N44066 AL133684 A1807085 AA808009 AA915914 F00007 AA019749 AL121560 AW675544AW090233 AW072071 A1810932 A1089733 AW026222 AA770155 A1089647 A1085733 AW516061 AL037636 AL037635 Ai863947 H50420 R11203 AA019133 N94772 N71842 N29047 AA778138 AA554336 AA179865 N59453 T65212 AA054270 AW806630 AA533375 D13146 AA349487 AU077160 BE255671 BE276795 BE250823 AL120301 BE311390 BE252483 424945 245223_1 AI221919119967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 Al341345 AW298800 AA724961 AA931158 A1741227 A1806660 A1982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 A1492961 A1361526 F04002 AA452141 T23551 A1472655 Al 193667 A1341984 N92658 T32870 R52664 N50428 AW089291 Al934175 Al423737 D60665 424947 245247_1 R77952 AA348809 AW959960 AW959962 A1565552 AW070702 AA973910 R85973 425331 250199 1 AW962128 AA355353 AA427363 426413 266650 1 AA377823 AW954494 A1022688 426503 268283 1 AA380153 AA380233 AW963529 426919 273507 1 AL041228 D82004 D61361 AI203314 AI990307 AW900295 A1018308 AW087473 AW183530 AA393346 H50055 AA935601 428342 290035_2 Al739168 M426249 Al199636 AW505198 AW977291 AA824583 AA883419 AA724079 A1015524 Al377728AW293682 Al928140 M731438 A1092404 A1085630 AA731340 429007 298301_1 D80642 M443145 AL11901 5 AW904500 429163 300543 1 AA884766 AW974271 AA592975 AA447312 429421 30431 1 AL031658 Api693758 AL040619 AW977914 AA811957 A1352198 AW104364 AA648367 AA897604 AW341668 A1201382 AL040620 430183 31412 2 BE010038 AA676833 A1311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 A1936370 M552514 T67280 AA039909 430676 32168 1 AF084866 AF084870 AF084864 AF084867 AF084869 AF084865 AF084868 AW818206 AW812038 BE144813 BE144812AW812041 AW812040 AW812067 BE061583 BE061604 T05808 A1352469 AA580921 BE141783 BE141782 BE061601 AW814393 AW885029 430968 326269 1 AW972830 AA527647 AA489820 AA570362 433009 357371 1 AA761668 AA573621 R92814 R09670 433434 366095 1 AA588429 A1972567 AW504832 A1299694 433523 368873_1 H29882 AW665533 AW149901 Al572917 M598500 A1636466AI336390 AW864390 AW864320 435542 407744 1 AA687376 H74234 AW975503 437034 431713 1 AA742643 AA808575 AW976668 437056 432262 A1147061M743380M765223AW976398A1803927 438458 457837 1 AW975186 AA807807 D29548 439285 47065 1 AL133916 N79113 AF086101 N76721 AW950828 AA364013 AW955684 A1346341 A1867454 N54784 A1655270 A1421279 AW014882 AA775552 N62351 N59253 AA626243 A1341407 BEl 75639 AA456968 A1358918 AA457077 439518 47334 1 W76326 AF086341 W72300 439566 47387 1 AF086387 W77884 W72711 441102 509604 1 AA973905 A1299888 AA917019 H63235 T90771 446692 689623 1 144514 AI352097 AI803984 AW235923 AW196558 Al954637 A1336983 447197 711623 1 R36075 A1366546 R36167 448044 747196 1 A1458682H24240R14537R18426AW867082 449625 81 1 NM 014253 AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760 N48674 A1375997 R45432 D59344 Al203107 F07491 R35360 R25094 A1913631 A1498402 T61382 A1016320 N45526 T61415 AA331486 450375 83327 1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532 AA190993H03231H59605H01642AA852876AA113758AA626915AA746952AH 61014AA099554R69067 450582 83933-1 A1339732 AA010300 AW515041 AA768334 N29860 AA425874 AA425118 AA865829 AW936878 451320 86576_1 AW118072 A1631982 T15734 AA224195 A1701458 W20198 F26326 AA890570 N90552 AW071907 A1671352 A1375892 T03517 R88265 AI124088 AA224388 A1034316 Al354686 T33652 AI140719 AI720211 T03490 A1372637 Ti5415 AW205836 AA630384 T03515 T33230 AA017131 AA443303 T33623 A1222556 T33511 T33785 A1419606 055612 453331 96214_1 A1240665 T53681 N77468 H51833 AA147247 R75732 C18450 R73999 A1095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292 R31981 H12498 H02668 AA035018 R75957 A1803329 R27528 R36203 A1809932 A1808765 R78948 AA411449 AA976929 A1378760 A1378620 T48870 R73906 R75632 H03612 AA909684 N50695 H02580 H12839 N58781 AA742532 A1360919 H03502 BE208298 R68588 A1350463 R31935 AW069127 M411621 R25671 R35105 H12451 H03869 H51263 M035486 R25109 R25110 M147933 453739 979419_t AL120266 AW269469 AW890114 454171 1049240 1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 455646 1348557 1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 458912 823104_1 A1911066 AI933734 A1680888 AJ003599 TABLE 15C : Pkey : Unique number corresponding to an Eos probeset

Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et refers to the publication entitled'The DNA sequence of human chromosome 2T Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 400533 6981826 Minus 277132-277595 400777 8131663 Plus 70745-71121 401272 9797373 Minus 9837498509 402145 8018280 Plus 113086-114800 402604 9909420 Plus 20393-20767 402605 9909420 Minus 47680-47973 402855 9662953 Minus 59763-59909 403142 9444521 Plus 89286-90131 403341 8569175 Plus 30699-30910 403696 3135242 Minus 143467-143634 403790 8084957 Minus 87826-87947, 8983590002 404150 7534008 Plus 165811-165943 404283 2276311 Minus 99460-99564 404541 8318559 Plus 103456-103664 404584 9857511 Plus 138651-139153 404632 9796668 Plus 45096-45229 404819 4678240 Plus 16223-16319, 16427-16513, 1673&16859, 16941-17075, 17170-17287, 17389-17529, 18261-18357, 1844318578 405238 7249119 Minus 51728-51836 405239 7249119 Plus 144345144464, 144690-144836. 151750-151883, 152407-152484 405348 2914717 Minus 43310-43462 405605 5836195 Minus 117070-117270 405819 4007557 Plus 2830-2967 TABLE 16A ABOUT 859 GENES UP-REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL CENTRAL NERVOUS SYSTEM Table 16A lists about 859 genes up-regulated in glioblastoma multforma (GBM) compared to normal central nervous system (CNS). These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average"LGG to'average'CNS tissues was greater than or equal to 3. 0. The'average'GBM level was set to the 85b percentile amongst various GBM tumors. The"average'normal CNS tissue level was set to the 8511 percentile amongst vrious CNS tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10^ percenSle vaue amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene 6Ue R1 : Ratio of GLIOBLASTOMA MULTIFORMA to CNS Pkey ExAccn UnigenelD Unigene Titie R1 414555 N98569 Hs. 76422 phospholipase A2, group IIA (platelets, 47. 2 422737 M26939 Hs. 119571 collagen, type Iil, alpha 1 (Ehlers-Danl 44. 9 423961 D13666 Hs. 136348 periostin (OSF-2os) 33. 3 433001 AF217513 Hs. 279905 clone HCiO310 PR00310p1 25. 9 449539 W80363 Hs. 58446 ESTs 25. 8 417308 H60720 Hs. 81892 KIAA0101 gene product 23. 3 424800 AL035588 Hs. 153203 MyoD family inhibitor 23. 0 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 19. 6 431941 AK000106 Hs. 272227 Homo sapiens cDNA FW20099 hs, clone CO 18. 7 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 17. 8 444190 A1878918 Hs. 10526 cysteine and glycine-rich protein 2 17. 8 428330 L22524 Hs. 2256 matrix metalloproteinae 7 (matrilysin, 17. 7 417130 AW276858 Hs. 81256 S100 calcium-binding protein A4 (calcium 17. 5 414217 AI309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 17. 0 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 15. 9 425397 J04088 Hs. 156346 topoisomerase (DNA) II alpha (170kD) 15. 6 424635 AA420687 Hs. 115455 Homo sapiens CDNA FU 14259 fis, clone PL 15. 2 408243 Y00787 Hs. 624 interleukin 8 14. 7 422672 X12784 Hs. 119129 collagen, type IV, alpha 1 14. 7 434078 AW880709 Hs. 283683 chromosome 8 open reading frame 4 14. 6 409799 D11928 Hs. 76845 phosphoserine phosphatase-like 14. 2 414761 AU077228 Hs. 77256 enhancer of zeste (Drosophila) homolog 2 14. 2 442432 BE093589 Hs. 38178 hypothetical protein FU23468 14. 1 446584 U53445 Hs. 15432 downregulated in ovarian cancer 1 14. 0 444969 A1203334 Hs. 160628 ESTs 13. 5 430691 C14187 Hs. 103538 ESTs 12. 9 426075 AW513691 Hs. 270149 ESTs, Weakly similar to 2109260A B cell 12. 4 445101 T75202 Hs. 12314 Homo sapiens mRNA ; cDNA DKFZp586C1019 (f 12. 1 441269 AW015206 Hs. 178784 ESTs 11. 9 417426 NM002291 Hs. 82124 laminin, beta 1 11. 9 430132 AA204686 Hs. 234149 hypothetical protein FLJ20647 11. 8 422163 AF027208 Hs. 112360 prominin (mouselike 1 11. 3 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAA1330 protein 11. 3 449722 BE280074 Hs. 23960 cyclin B1 11. 2 436291 BE568452 Hs. 344037 protein regulator of cytokinesis 1 11. 0 435020 AW505076 Hs. 301855 DiGeorge syndrome critical region gene 8 10. 9 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 10. 9 419239 AA468183 Hs. 184598 Homo sapiens cDNA : FLJ23241 fis, clone C 10. 6 417043 NM004369 Hs. 80988 collagen, qpeVl, alpha3 10. 6 413929 BE501689 Hs. 75617 collagen, type IV, alpha 2 10. 6

420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 10. 6 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 10. 4 406972 M32053 gb : Human H19 RNA gene, complete cds. 10. 4 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) 10. 3 419508 AW997938 Hs. 90786 ATP-binding cassette, sub-family C (CFTR 10. 3 449611 A1970394 Hs. 197075 ESTs 10. 1 427581 NM 014788 Hs. 179703 KIAAOI 29 gene product 10. 1 431512 BE270734 Hs. 2795 lactate dehydrogenase A 9. 9 429183 AB014604 Hs. 197955 KIAA0704 protein 9. 8 433437 U20536 Hs. 3280 caspase 6, apoptosis-related cysteine pr 9. 7 424840 D79987 Hs. 153479 extra spindle poles, S. cerevisiae, homo 9. 7 433800 A1034361 Hs. 135150 lungqpe-lllmembrane-asociatedgly 9. 7 433647 AA603367 Hs. 222294 ESTs 9. 7 414622 Api752666 Hs. 76669 nicotinamide N-methyltransferase 9. 5 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy 9. 3 409461 AA382169 Hs. 54483 N-myc (and STAT) interactor 9. 3 409902 Al337658 Hs. 156351 ESTs 9. 3 450375 AA009647 a disintegrin and metalloproteinase doma 9. 2 445873 AA250970 Hs. 251946 pdy (A) binding pnotein, cytoplasmic 1-9. 1 442802 AL133035 Hs. 8728 hypothetical protein DKFZp434G171 9. 1 452461 N78223 Hs. 108106 transcription factor 9. 1 434846 AW295389 Hs. 119768 ESTs 9. 1 422158 L10343 Hs. 112341 protease inhibitor 3. skin-derived (SKAL 9. 0 425187 AW014486 Hs. 22509 ESTs 9. 0 443247 BE614387 Hs. 333893 c-Myc target JP01 8. 7 458079 A1796870 Hs. 54277 DNA segment on chromosome X (unique) 992 8. 7 410276 A1554545 Hs. 68301 angiopoietin-2 8. 6 402855 NM001839' : Homo sapiens calponin 3, acid 8. 6 439710 AF086543 gb : Homo sapiens full length insert cDNA 8. 6 411968 Api207410 Hs. 69280 Homo sapiens, clone IMAGE : 3636299, mRNA, 8. 6 410102 AW248508 Hs. 279727 ESTs : homoloXqueofPEM-3íCionasavignyi 8. 6 436895 AF037335 Hs. 5338 carbonic anhydrase XII 8. 6 418203 X54942 Hs. 83758 CDC28 protein kinase 2 8. 6 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 8. 5 425234 AW152225 Hs. 165909 ESTs. Weakly similar to l38022 hypotheti 8. 5 449961 AW265634 Hs. 133100 ESTs 8. 5 449444 AW818436 Hs. 23590 solute carrier family 16 (monocarboxylic 8. 4 417061 A1675944 Hs. 188691 Homo sapiens cDNA FLJ 12033 fis, clone HE 8. 3 453884 AA355925 Hs. 36232 K ! AA0186 gene product 8. 3 424085 Nom 002914 Hs. 139226 replication factor C (activator 1) 2 (40 8. 2 419938 AU076772 Hs. 1279 comp ! ementcomponent1. rsubcomponent 8. 1 411078 A1222020 Hs. 182364 CocoaCrisp 8. 1 406850 A1624300 Hs. 172928 collagen, type 1, alpha 1 8. 0 447726 AL137638 Hs. 19368 matnlin 2 8. 0 439999 AA115811 Hs. 6838 ras homolog gene family, member E 8. 0 416658 U03272 Hs. 79432 fibriliin 2 (congenital contractural ara 7. 9 439451 AF086270 Hs. 278554 heterochromatin-like protein 1 7. 9 458814 A1498957 Hs. 170861 ESTs, WeaklysimilartoZ195_HUMANZINC 7. 9 447004 AW296968 Hs. 157539 ESTs 7. 9 436140 W87355 Hs. 269587 ESTs 7. 9 436607 AW661783 Hs. 211061 ESTs 7. 8 422809 AK001379 Hs. 121028 hypothetical protein FLJ10549 7. 7 440052 A1633744 Hs. 195648 ESTs, Weakly similar to 138022 hypotheb 7. 7 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 7. 7 418113 Api272141 Hs. 83484 SRY (sex determining region Y)-box 4 7. 7 410286 A1739159 Hs. 61898 DKFZP586N2124 protein 7. 7 424687 J05070 Hs. 151738 matrixmetalloproteinae9 (gelatinaeB 7. 6 422048 NM_012445 Hs. 288126 spondin 2, extracellular matrix protein 7. 6 421988 AW450481 Hs. 161333 ESTs 7. 6 452620 AA436504 Hs. 119286 ESTs 7. 6 453941 U39817 Hs. 36820 Bloom syndrome 7. 5 416737 AF154335 Hs. 79691 LIM domain protein 7. 5 425289 AW139342 Hs. 155530 interferon, gamma-inducible protein 16 7. 5 418400 BE243026 Hs. 301989 KIAA0246 protein 7. 5 437036 A1571514 Hs. 133022 ESTs 7. 5 421899 AJ011895 Hs. 109281 Nef-associated factor 1 7. 4 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 7. 4 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 7. 4 427871 AW992405 Hs. 59622 Homo sapiens, clone IMAGE : 3507281, mRNA, 7. 3 448935 AL078596 Hs. 22591 nuclear receptor subfamily 2, group E, m 7. 3 415079 R43179 Hs. 22895 hypotheticalprotein FU23548 7. 3 449571 AW016812 Hs. 200266 ESTs 7. 3 427899 AA829286 Hs. 332053 serum amyloid A1 7. 3 447458 A1741082 Hs. 158961 ESTs 7. 3 430630 AW269920 Hs. 2621 cystatin A (stefin A) 7. 2 411252 AB018549 Hs. 69328 MD-2 protein 7. 2 432731 R31178 Hs. 287820 fibronectint 7. 2 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 7. 2 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 30-sulfot 7. 2 428728 NM 016625 Hs. 191381 hypothetical protein 7. 1 416111 AA033813 Hs. 79018 chromatin assembly factor 1, subunit A (7. 1 432281 AK001239 Hs. 274263 hypothetical protein FLJ10377 7. 1 410434 AF051152 Hs. 63668 toll-likeeptor2 71

420018 U56387 Hs. 94376 propnotein convertase subtilisin/kexin t 7. 1 418293 A1224483 Hs. 16063 hypothetical protein FLJ21877 7. 1 424954 NM 000546 Hs. 1846 tumor protein p53 (Li-Fraumeni syndrome) 7. 0 445900 AF070526 Hs. 125036 Homo sapiens clone 24787 mRNA sequence 7. 0 419741 NM007019 Hs. 93002 ubiquitin carrier protein E2-C 7. 0 422283 AW411307 Hs. 114311 CDC45 (cell division cycle 45, S. cerevis 7. 0 434808 AF155108 Hs. 256150 Homosapiens, SimilartoRIKENcDNA2810 6. 9 416847 L43821 Hs. 80261 enhancer of filamentation I (cas-like do 6. 9 424381 AA285249 Hs. 146329 protein kinase Chk2 6. 9 410064 X53416 Hs. 195464 filamin A, alpha (ac6n-binding protein-6. 9 415682 A1347128 Hs. 191870 ESTs 6. 9 421977 W94197 Hs. 110165 nbosoma'proteinL26homofog 6. 8 429447 AW812452 Hs. 83286 ESTs, Weakly similar to S14747 sphingomy 6. 8 423198 M81933 Hs. 1634 cell division cycle 25A 6. 8 413627 BE182082 Hs. 246973 ESTs 6. 8 412777 A1335773 Hs. 270123 ESTs 6. 8 409829 M33552 Hs. 56729 lymphocyte-specific protein 1 6. 8 451129 BE072881 gb : RC2-BT0548-200300-012-eO9 BT0548 Homo 6. 8 444381 BE387335 Hs. 283713 ESTs. Weakly similar to S64054 hypotheti 6. 7 446131 NM 000929 Hs. 290 phospholipase A2, group V 6. 7 441703 AW390054 Hs. 192843 leucine zipper protein FKSG14 6. 7 420311 AW445044 Hs. 38207 Human DNA sequence from clone RP4-530115 6. 7 425202 AW962282 Hs. 152049 ESTs, Weakty simitar to 138022 hyphe6 6. 7 408161 AW952912 Hs. 300383 hypothetical protein MGC3032 6. 7 440704 M69241 Hs. 162 insulin-like growth factor binding prote 6. 7 407182 AA312551 Hs. 230157 ESTs 6. 7 445837 A1261700 Hs. 145544 ESTs 6. 6 433376 A1249361 Hs. 74122 capae 4, apptosis-elated cysteine pr 6. 6 431211 M86849 Hs. 323733 gap junction protein, beta 2, 26kD (conn 6. 6 447439 AA313565 Hs. 145020 ESTs, Weakly similar to KIAA1205 protein 6. 5 407235 D20569 Hs. 169407 SAC2 (suppressor of acts mutations 2, y 6. 5 450506 NM 004460 fibroblast activation protein, alpha 6. 5 432593 AW301003 Hs. 51483 ESTs. Weakly similar to hypotheticat pro 6. 5 418054 NM_002318 Hs. 83354 lysyl oxidase-like 2 6. 5 452799 A1948829 Hs. 213786 ESTs 6. 5 446657 A1335191 Hs. 260702 ESTs, Weakly similar to 2109260A B cell 6. 4 424247 X14008 Hs. 234734 lysozyme (renal amyloidosis) 6. 4 443884 N20617 Hs. 194397 leptin receptor 6. 4 420560 AW207748 Hs. 59115 ESTs 6. 4 419485 AA489023 Hs. 99807 ESTs, Weakly similar to unnamed protein 6. 3 420649 AI866964 Hs. 124704 ESTs, Moderately similar to S65657 alpha 6. 3 457465 AW301344 Hs. 122908 DNA replication factor 6. 3 440332 A1218517 Hs. 188051 ESTs 6. 3 449246 AW411209 Hs. 23363 hypothetical protein FLJ10983 6. 3 413063 AL035737 Hs. 75184 chitinase Mike 1 (cartilage gtycoprote 6. 2 448275 BE514434 Hs. 20830 hinesin iike 2 6. 2 440286 U29589 Hs. 7138 cholinergicreceptor, muscannic3 6. 2 439518 W76326 gb : zd60dO4. r1 Soares fetal_heart_NbHH19W 6. 1 412567 A1750979 Hs. 74034 Homo sapiens clone 24651 mRNA sequence 6. 1 426935 NM 000088 Hs. 172928 collagen, type 1, alpha 1 6. 1 456977 AK000252 Hs. 169758 hypothetical protein FLJ20245 6. 1 428450 NM014791 Hs. 184339 KIAA0175 gene product 6. 0 412125 Y17114 Hs. 73393 eyes absent (Drosophila) homolog 4 6. 0 413786 AW613780 Hs. 13500 ESTs 6. 0 410555 U92649 Hs. 64311 adisintegnnandmetalloproteinaedoma 5. 9 400419 AF084545 Target 5. 9 408380 AF123050 Hs. 44532 diubiqui6n 5. 9 426108 AA622037 Hs. 166468 programmed cell death 5 5. 9 414774 X02419 Hs. 77274 plasminogen activator, urokinase 5. 9 437695 AA769202 Hs. 192142 ESTs 5. 8 409463 A1458165 Hs. 17296 hypothetical protein MGC2376 5. 8 411048 AK001742 Hs. 67991 hypothetical protein DKFZp434G0522 5. 8 443731 A1083928 Hs. 145418 ESTs 5. 8 405558 Target Exon 5. 8 422094 AF129535 Hs. 272027 F-box only protein 5 5. 8 429113 D28235 Hs. 196384 prostagiandin-endoperoxide synthase 2 (p 5. 8 425882 U83115 Hs. 161002 absent in melanoma 1 5. 8 412471 M63193 Hs. 73946 endothelial cell growth factor 1 (platel 5. 8 429149 AW193360 Hs. 197962 ESTs, Weakly similar to 138022 hypotheti 5. 8 436827 H72187 Hs. 5322 guanine nucleotide binding protein (G pr 5. 7 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring tinge 5. 7 414053 BE391635 Hs. 75725 transgelin 2 5. 7 436805 AA731533 Hs. 270751 ESTs 5. 7 442201 AW516704 Hs. 208726 ESTs 5. 7 453361 AA035197 Hs. 107375 ESTs 5. 6 429083 Y09397 Hs. 227817 BCL2-related protein A1 5. 6 426490 NM001621 Hs. 170087 aryl hydrocarbon receptor 5. 6 423081 AF262992 Hs. 123159 sperm associated antigen 4 5. 6 407013 U35637 gb : Human nebulin mRNA, partial cds 5. 5 406478 Target Exon 5. 5 435937 AA830893 Hs. 119769 ESTs 5. 5 453362 H14988 Hs. 107375 ESTs 5. 5 449969 AW295142 Hs. 180187 Homo sapiens cDNA FW14337 hs, clone PL 5. 5

442547 AA306997 Hs. 217484 ESTs, Weakly similar to ALU7 HUMAN ALU S 5. 5 443883 AA114212 Hs. 9930 serine (or cysteine) proteinase inhibito 5. 5 429643 AA455889 Hs. 167279 FYVE-finger-containing Rab5 effector pro 5. 5 407862 BE548267 Hs. 337986 Homo sapiens cDNA FLJ 10934 fis, clone OV 5. 4 407624 AW157431 Hs. 248941 ESTs 5. 4 448769 N66037 Hs. 38173 ESTs 5. 4 417124 BE122762 Hs. 25338 ESTs 5. 4 422493 AW474183 Hs. 250173 hypothe6cal protein FW13158 5. 4 457292 Api921270 Hs. 281462 hypothetical protein FLJ14251 5. 3 418596 AW976721 Hs. 293327 ESTs 5. 3 410295 AA741357 Hs. 5174 nidogen (enactin) 5. 3 433323 AA805132 Hs. 159142 ESTs 5. 3 412326 R07566 Hs. 73817 smatl inducible cytokine A3 (homologous 5. 3 418630 Al351311 Hs. 251946 po) y (A)-binding protein, cytopiasmid-i 5. 3 420075 AF142482 Hs. 203846 TEA domain family member 3 5. 2 427676 AA394062 Hs. 300772 tropomyosin 2 (beta) 5. 2 407729 T40707 Hs. 270862 ESTs 5. 2 416908 AA333990 Hs. 80424 coagulation factor XIII, A1 polypeptide 5. 2 414372 AA143654 gb : zo65aO2. r1 Strgaaqene pancrea (93720 5. 2 433556 W56321 Hs. 111460 ca'cium/calmodulin-dependentproteinkin 5. 2 424998 U58515 Hs. 154138 chitine 3-like 2 5. 2 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, 5. 2 445118 A1208762 Hs. 345572 ESTs 5. 2 408523 AW833259 Hs. 314287 ESTs 5. 2 412530 AA766268 Hs. 266273 hypothetical protein FW13346 5. 2 449300 A1656959 Hs. 346514 ESTs 5. 2 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2 doma 5. 2 423757 AL049337 Hs. 132571 Homo sapiens mRNA ; cDNA DKFZp564P016 (fr 5. 1 439570 T79925 Hs. 269165 ESTs, Weakly similar to ALU 1-HUMAN ALU S 5. 1 415323 BE269352 Hs. 949 neutrophil cytosolic factor 2 (65kD, chr 5. 1 443604 C03577 Hs. 9615 myosin regulatory light chain 2, smooth 5. 1 421247 BE391727 Hs. 102910 generaltranscnpUonfætorllH, plype 5. 1 416913 AW934714 gb : RC1-DT0001-031299-011-a11 DT0001 Homo 5. 1 419968 X04430 Hs. 93913 interleukin 6 (interferon, beta 2) 5. 0 424009 F11690 gb : HSC30D041 normalized infant brain cDN 5. 0 418283 S79895 Hs. 83942 cathepsinK (pycnodysostosis) 5. 0 429469 M64590 Hs. 27 gtycinedehydrogenase (decarboxytating : 5. 0 417404 NM 007350 Hs. 82101 pleckstrin homology-like domain, family 5. 0 408829 NM006042 Hs. 48384 heparan sulfate (glucosamine) 3-0-sulfot 5. 0 418097 R45137 Hs. 21868 ESTs 5. 0 453331 Al240665 ESTs 4. 9 429433 AA452899 Hs. 213586 ESTs, Weakly similar to KIAA1353 protein 4. 9 426044 AA502490 Hs. 170290 ESTs 4. 9 444161 N52543 Hs. 142940 ESTs 4. 9 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 4. 9 432242 AW022715 Hs. 162160 ESTs, Weakly similar to ALU4_HUMAN ALU S 4. 9 447752 M73700 Hs. 105938 lactotransferrin 4. 9 439627 BE621702 Hs. 29076 hypothetical protein FLJ21841 4. 9 402274 C19000498' : gi ! 4567179gb ! AAD23607. 1ACOO 4. 9 444656 A1277924 Hs. 145199 ESTs 4. 9 422087 X58968 Hs. 111301 matrixmeta'loproteinae2 (gelatinaeA 4. 9 443744 A1084326 Hs. 271548 ESTs, Weakly similar to 178885 serine/th 4. 9 416871 H98716 gb : yx13d08. s1 Soares melanocyte 2NbHM Ho 4. 9 409112 BE243971 Hs. 50649 quinoneoxidoreductaehomolog 4. 8 403481 Target Exon 4. 8 443740 R56434 Hs. 21062 ESTs 4. 8 435005 U80743 Hs. 306094 trinucleotiderepeatcontaining 12 4. 8 429163 AA884766 gb : am20a10. s1 Soares_NFL T_GBC_S1 Homos 4. 8 451418 BE387790 Hs. 26369 hypothetical protein FLJ20287 4. 8 428403 A1393048 Hs. 326159 leucine rich repeat (in FLII) interactin 4. 8 430968 AW972830 gb : EST384925 MAGE resequences, MAGL Homo 4. 8 425212 AW962253 Hs. 171618 ESTs 4. 8 409205 Api952884 Hs. 14832 ESTs, Moderately similar to unnamed prot 4. 8 431176 A1026984 Hs. 293662 ESTs 4. 8 420092 AA814043 Hs. 88045 ESTs 4. 8 437834 AA769294 Hs. 283854 gb : nz36gO3. s1 NCI_CGAP_GCB1 Homo sapiens 4. 8 432363 AA534489 gb : nf769H. s1NCLCGAPCo3 Homo sapiens 4. 8 403011 ENSP00000215330-: Pnobableserine/threoni 4. 7 405348 C7001664 : gil12698061ldbjlBAB21849. 1l (AB 4. 7 447072 D61594 Hs. 17279 tyrosyiproteinsuifotransferaset 4. 7 443318 A1051603 Hs. 133141 ESTs 4. 7 421027 AA761198 Hs. 55254 ESTs 4. 7 449318 AW236021 Hs. 78531 Homo sapiens, Similar to RIKEN cDNA 5730 4. 7 429170 NM 001394 Hs. 2359 dual specificity phosphatase 4 4. 7 411852 AA528140 Hs. 107515 ESTs, WeaklysimilartoT00329hyptheti 4. 7 450166 AA429504 ESTs 4. 7 438456 AA913381 Hs. 20594 ESTs 4. 7 446839 BE091926 Hs. 16244 mitotic spindle coiled-coil related pmt 4. 7 438527 Al969251 Hs. 115325 RAB7, member RAS oncogene family-like 1 4. 7 458946 AA009716 Hs. 42311 ESTs 4. 7 454860 AW835767 gb : OV4LT0016-240200-110-bO8LT0016Homo 4. 7 424736 AF230877 Hs. 152701 micmtubule-interacting protein that ass 4. 7 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 4. 6

422648 D86983 Hs. 118893 Melanoma associated gene 4. 6 431319 AA873350 Hs. 302232 ESTs 4. 6 445666 R59960 Hs. 282386 ESTs 4. 6 416406 D86961 Hs. 79299 lipoma HMGIC fusion partner-like 2 4. 6 422887 A1751848 Hs. 49215 ESTs 4. 6 422938 NM_001809 Hs. 1594 centromere protein A (17kD) 4. 6 405141 Y14443 zinc finger protein 200 4. 6 440210 AW674562 Hs. 125296 ESTs 4. 6 432527 AW975028 Hs. 102754 ESTs 4. 6 439726 AW449893 Hs. 293707 ESTs, Weakly similar to 138598 zinc fing 4. 6 435143 R12375 Hs. 194600 ESTs 4. 6 422170 A1791949 Hs. 112432 an6-Mullerian hommone 4. 6 452874 AK001061 Hs. 30925 hypothetical protein FUI0199 4. 6 408996 A1979168 Hs. 344096 glycoprotein (transmembrane) nmb 4. 6 412568 Api878826 Hs. 74034 caveolin 1, caveolae protein, 22kD 4. 5 426215 AW963419 Hs. 155223 stanniocalcin 2 4. 5 413076 U10564 Hs. 75188 wee1 (S. pombe) homolog 4. 5 456759 BE259150 Hs. 127792 delta (Drosophila)-like 3 4. 5 419735 AW750056 Hs. 169577 Homo sapiens cDNA FW14743 hs, clone NT 4. 5 433675 AW977653 Hs. 75319 ribonucieoUde reductase M2 polypeptide 4. 5 441217 A1922183 Hs. 213246 ESTs 4. 5 435542 AA687376 ESTs 4. 5 440435 AL042201 Hs. 21273 transcrip6onfactor NYD-splO 4. 5 400288 X06256 Hs. 149609 integnn. alpha 5 (fibronectin receptor. 4. 5 416114 A1695549 Hs. 183868 glucuronidase, beta 4. 5 437323 AA371145 Hs. 194397 feptin receptor 4. 5 425139 AW630488 Hs. 25338 protease, serine, 23 4. 5 423678 AW963357 Hs. 7847 ESTs 4. 5 403961 Target Exon 4. 5 443462 A1064690 Hs. 171176 ESTs 4. 5 418483 W26076 Hs. 221847 ESTs 4. 5 428873 A1701609 Hs. 98908 ESTs 4. 5 410268 AA316181 Hs. 61635 six transmembrane epithelial antigen of 4. 5 408298 A1745325 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 4. 5 449145 A1632122 Hs. 198408 ESTs 4. 4 439574 A1469788 Hs. 165190 ESTs 4. 4 423905 AW579960 Hs. 135150 lung type-I cell membrane-associated gly 4. 4 453387 A1990741 Hs. 252809 ESTs 4. 4 447444 AK000318 Hs. 18616 hypothetical protein FU20311 4. 4 433507 A1817336 Hs. 191791 ESTs 4. 4 448048 BE281291 Hs. 170408 ESTs, Moderately similar to A47582 B-cel 4. 4 421064 AI245432 Hs. 101382 tumor necrosis factor, alpha-induced pro 4. 4 402604 Target Exon 4. 4 446291 BE397753 Hs. 14623 interferon, gamma-inducible protein 30 4. 4 424503 Nom002205 Hs. 149609 integrin, alpha 5 (fibronectin receptor. 4. 4 423600 A1633559 Hs. 310359 ESTs 4. 4 403361 NM002210' : Homo sapiens integrin, alpha 4. 4 408432 AW195262 gb : xn67bO5. x1 NCI_CGAP_CML1 Homosapiens 4. 4 424489 T48851 Hs. 274470 D-sigle precursor, 4. 3 442264 A1278777 Hs. 263455 ESTs, WeaklysimilartoALU1 HUMANALUS 4. 3 447247 AW369351 Hs. 287955 Homo sapiens cDNA FLJ 13090 fis, clone NT 4. 3 417018 M16038 Hs. 80887 v-yes-1 Yamaguchi sarcoma viral related 4. 3 414020 NM002984 Hs. 75703 small inducible cytokine A4 (homologous 4. 3 439566 AF086387 gb : Homo sapiens full length insert cDNA 4. 3 425242 D13635 Hs. 155287 KIAA0010 gene product 4. 3 423529 T87318 Hs. 120411 ESTs 4. 3 439538 AA837323 Hs. 56407 ESTs 4. 3 453682 T79703 gb : yd71eO8. r1 Soares fetal liver spleen 4. 3 425259 AL049280 Hs. 155397 Homo sapiens mRNA ; cDNA DKFZp564K143 (fr 4. 3 417918 AA209205 Hs. 163754 hypothetical protein FU12606 4. 3 426649 Al914936 Hs. 97152 ESTs 4. 3 438875 AA827640 Hs. 189059 ESTs 4. 3 445868 BE169357 Hs. 207428 ESTs 4. 3 426509 M31166 Hs. 2050 pentaxin-related gene, rapidly induced b 4. 3 409893 AW247090 Hs. 57101 minichromosome maintenance deficient (S. 4. 3 432058 AW665996 Hs. 130729 ESTs, Weakly similar to ALU1HUMANALUS 4. 3 430694 AA810624 Hs. 30936 ESTs, WeaklysmilartoH2BH_HUMANHIST0 4. 3 441523 AW514263 Hs. 301771 ESTs, Weakly similar to ALUF HUMAN ! ! ! ! 4. 2 443950 NM_001425 Hs. 9999 epithelial membrane protein 3 4. 2 419896 Z99362 gb : HSZ99362 DKFZphamy1 Homo sapiens cDNA 4. 2 452994 AW962597 Hs. 31305 KIAA1547 protein 4. 2 420841 At625251 Hs. 94037 hypothetical protein FW23053 4. 2 441255 R06350 Hs. 171635 ESTs 4. 2 416426 AA180256 Hs. 210473 Homo sapiens cDNA FLJ14872 fis, clone PL 4. 2 411789 AF245505 Hs. 72157 Adlican 4. 2 409638 AW450420 Hs. 21335 ESTs 4. 2 439192 AW970536 Hs. 105413 ESTs 4. 2 440684 Api253123 Hs. 127356 ESTs, Highly similar to S21424 nes6n [H 4. 2 437470 AL390147 Hs. 134742 hypotheticalprotein DKFZp547D065 4. 2 432343 NM_002960 Hs. 2961 S100 calcium-binding protein A3 4. 2 401454 NM014226' : Homo sapiens renal tumor anti 4. 2 431770 BE221880 Hs. 268555 5'-3'exoribonuclease 2 4. 2 442326 H92962 Hs. 124813 hypothetical protein MGC14817 4. 2

419402 Z68155 Hs. 90291 laminin, beta 2 (laminin S) 4. 2 435703 AW630133 Hs. 83313 GK003 protein 4. 2 444609 AW571659 Hs. 278081 ESTs 4. 2 404407 Target Exon 4. 2 450581 AF081513 Hs. 25195 TGF-beta4 4. 2 407838 BE146411 Hs. 40342 putative nuclear protein 4. 1 410407 X66839 Hs. 63287 carbonic anhydrase ! X 4. 1 418883 BE387036 Hs. 1211 acid phosphatase 5. tartrate resistant 4. 1 438898 A1819863 Hs. 106243 ESTs 4. 1 421674 T10707 Hs. 296355 hypothetical protein FU23138 4. 1 445921 AW015211 Hs. 146181 ESTs 4. 1 453055 AW291436 Hs. 31917 Homo sapiens, clone MGC : 9658, mRNA, comp 4. 1 413450 Z99716 Hs. 75372 N-acetylgalactosaminidase, alpha-4. 1 427463 AA442224 Hs. 97900 ESTs 4. 1 450639 A1703186 Hs. 277174 ESTs 4. 1 417576 AA339449 Hs. 82285 phosphoribosyigtycinamideformyttransfer 4. 1 437269 AA334384 Hs. 149420 ESTs 4. 1 415688 AA166963 gb : zo86dO1. s1 Sratagene ovarian cancer 4. 1 414300 A1304870 Hs. 188680 ESTs 4. 1 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa 4. 1 415024 A1983981 Hs. 189114 ESTs 4. 1 408102 U46351 Hs. 621 IecGn, galactoside-binding, soluble, 3 4. 1 448019 AW947164 Hs. 195641 ESTs, Moderately similar to 138022 hypot 4. 1 451433 AA021140 Hs. 269265 ESTs, Weakly similar to A46010 X-linked 4. 1 446523 NM003063 Hs. 334629 sarcotipin 4. 1 427700 Axa262294 Hs. 180383 dual specificity phosphatase 6 4. 1 402239 Target Exon 4. 1 423713 AW754182 gb : RC2-CT0321-131199-011-c01 CT0321 Homo 4. 1 437814 A1088192 Hs. 135474 ESTs, Weakly similar to DDX9_HUMAN ATP-D 4. 1 414948 C15240 Hs. 182155 ESTs 4. 0 421307 BE539976 Hs. 103305 Homo sapiens mRNA ; cDNA DKFZp434B0425 (f 4. 0 427375 AL035460 Hs. 177536 metallocarboxypep6dase CPX-1 4. 0 450297 AW901347 Hs. 38592 hypothetical protein FU23342 4. 0 449655 Al021987 Hs. 59970 ESTs 4. 0 439978 BE139460 Hs. 124673 HomosapenscDNAFW11477hs, cloneHE 40 432842 AW674093 Hs. 334822 hypothetical protein MGC4485 4. 0 422282 AF019225 Hs. 114309 aplipoprotein L 4. 0 452574 AF127481 Hs. 301946 lymphoidblastcrisisoncogene 4. 0 449256 AA059050 Hs. 59847 ESTs 4. 0 453385 AW296101 Hs. 252806 ESTs 4. 0 443715 A1583187 Hs. 9700 cyclin E1 4. 0 451778 Ai826131 Hs. 62954 ESTs, Weakly similar to zinc finger prot 4. 0 441287 AW293132 Hs. 131373 ESTs 4. 0 418661 NM 001949 Hs. 1189 E2Ftranscriptionfactor3 4. 0 420894 AA744597 Hs. 88854 ESTs 4. 0 454120 AB032990 Hs. 40719 hypothetical protein KIAA1164 4. 0 441627 AA947552 Hs. 58086 branched chain aminotransferase 1, cytos 4. 0 453948 A1970797 Hs. 64859 ESTs 4. 0 444170 AW613879 Hs. 102408 ESTs 4. 0 427221 L15409 Hs. 174007 von Hippel-Lindau syndrome 4. 0 418821 AA436002 Hs. 183161 ESTs 4. 0 418216 AA662240 Hs. 283099 AF15q14 protein 4. 0 435106 AA100847 Hs. 5978 ESTs, Highly similar to AF1746001F-box 4, 0 430890 X54232 Hs. 2699 glypican 1 3. 9 429490 Ai971131 Hs. 23889 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 9 425292 NM 005824 Hs. 155545 37 kDa leucine-rich repeat (LRR) protein 3. 9 436265 AA731331 Hs. 190668 ESTs 3. 9 407304 AA565832 Hs. 271649 gb : nj32bO3. s1 NCI_CGAP_M1 Homosapiens 3. 9 433244 AB040943 Hs. 271285 KIAA1510 protein 3. 9 446960 AW294936 Hs. 156762 ESTs 3. 9 406627 T64904 Hs. 163780 ESTs 3. 9 420552 AK000492 Hs. 98806 hypothetical protein 3. 9 402082 C18000743' : gil6678363leh ; NP_033416. 11t 3. 9 419594 AA013051 Hs. 91417 topoisomerase (DNA) 11 binding protein 3. 9 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 3. 9 427527 A1809057 Hs. 293441 immunoglobulin heavy constant mu 3. 9 422564 Al148006 Hs. 222120 ESTs 3. 9 418781 T41160 Hs. 8404 ESTs 3. 9 431820 AW410408 Hs. 271167 L-pipecolic acid oxidase 3. 9 413095 AA494359 Hs. 30715 potassium voltage-gated channel, Isk-rel 3. 9 430637 BE160081 Hs. 256290 S100 calcium-binding protein At 1 (ca) giz 3. 9 443539 A1076182 Hs. 134074 ESTs, ModeratelysimilartoALU6_HUMANA 3. 9 422173 BE385828 Hs. 250619 phorbolin-like protein MDS019 3. 9 433388 Api432672 Hs. 288539 hypothetical protein FLJ22191 3. 8 403849 Target Exon 3. 8 406646 M33600 Hs. 308026 major histocompatibility complex, class 3. 8 445075 A1651827 Hs. 344767 ESTs 3. 8 420004 AW975532 Hs. 164039 ESTs, Moderately similar to 138022 hypot 3. 8 449670 F07693 Hs. 85603 Homo sapiens mRNA ; cDNA DKFZp434K2172 (f 3. 8 424479 AF064238 Hs. 149098 smoothelin 3. 8 449625 NM_014253 odz (odd OzAen-m, Drosophila) homolog 1 3. 8 418641 BE243136 Hs. 86947 a disintegdn and metalloproteinase doma 3. 8 439979 AW600291 Hs. 6823 hypothetical protein FU10430 3. 8

427286 AW732802 Hs. 2132 epidermal growth factor receptor pathway 3. 8 453920 A1133148 Hs. 36602 I factor (complement) 3. 8 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 3. 8 406872 AI760903 gb : wiO9hO8. x1 NCI_CGAP_CLL1 Homosapiens 3. 8 403696 C4001100-: gil5852342jgblMD54015. 1l (AFO 3. 8 417791 AW965339 Hs. 111471 ESTs 3. 8 418036 Z37976 Hs. 83337 latent transforming growth factor beta b 3. 8 404209 Target Exon 3. 8 431454 AW975980 Hs. 292918 ESTs 3. 8 410422 AL042014 Hs. 63348 Homo sapiens, clone MGC : 15203, mRNA, com 3. 8 406739 A1566709 Hs. 182426 ribosome protein S2 3. 8 450810 BE207588 Hs. 334360 transforming growth factor beta 1 induce 3. 8 457876 Al821940 ESTs, Moderately similar to ALU8_HUMAN A 3. 8 435718 R06569 Hs. 269534 ESTs 3. 8 429716 R25685 Hs. 211933 coliagen, type Xill, alpha 1 3. 8 442710 A1015631 Hs. 23210 ESTs 3. 8 456534 X91195 Hs. 100623 phospholipase C, beta 3, neighbor pseudo 3. 8 419764 BE262524 Hs. 93183 vasodilator-stimulated phosphoprotein 3. 8 436674 AA725002 Hs. 272018 low molecular mass ubiquinone-binding pr 3. 8 408896 Api610447 Hs. 48778 niban protein 3. 8 425300 AW601773 Hs. 270259 ESTs 3. 8 432886 BE159028 Hs. 279704 chromatin accessibility complex 1 3. 8 424090 X99699 Hs. 139262 XIAP associated factor-1 3. 7 420202 AL036557 Hs. 95910 putabvelymphocyteGOlG1switchgene 3. 7 427584 BE410293 Hs. 179718 v-myb avian myeloblastosis viral oncogen 3. 7 420579 AA278449 Hs. 137429 ESTs 3. 7 406038 Y14443 zinc finger protein 200 3. 7 412590 AL134388 Hs. 135033 ESTs, Weakly similar to 138022 hypotheti 3. 7 406714 Al219304 Hs. 266959 hemoglobin, gamma G 3. 7 412014 A1620650 Hs. 43761 ESTs, Weakly similar to A46010 X-linked 3. 7 419713 AW968058 Hs. 92381 nudix (nucleoside diphosphate linked moi 3. 7 449115 AW959952 Hs. 37528 ESTs, WeaklysimilartoAF090944 1 PR006 3. 7 408955 BE315170 Hs. 8087 Target CAT 3. 7 441362 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re 3. 7 413774 AA131782 Hs. 182314 ESTs 3. 7 440225 BE295782 Hs. 159 tumor necrosis factor receptor superfami 3. 7 414528 AA148950 Hs. 188836 ESTs 3. 7 436137 A1056769 Hs. 133512 ESTs 3. 7 414733 BE514535 Hs. 77171 minichromosome maintenance deficient (S. 3. 7 406785 AA588061 gb : nk10d03. s1 NCI_CGAP_Co2 Homo sapiens 3. 7 443361 Al792628 Hs. 133273 ESTs 3. 7 434868 R50032 Hs. 159263 collagen, type VI, alpha 2 3. 7 409557 BE182896 Hs. 211193 ESTs 3. 7 420300 AA258245 Hs. 127573 Homo sapiens FKSG41 (FKSG41) mRNA, compl 3. 7 427695 R88483 Hs. 172862 ESTs 3. 7 407756 AA116021 Hs. 38260 ubiquitin specific protease 18 3. 6 437916 BE566249 Hs. 20999 hypothetical protein FLJ23142 3. 6 434563 AW083994 Hs. 9469 pleckstrin homology domain-containing, f 3. 6 444371 BE540274 Hs. 239 forkhead box M1 3. 6 437816 A1823445 Hs. 280699 ESTs 3. 6 405605 C2001342 : gil127814lsplP26434lNAH4_FAT SO 3. 6 444794 A1419991 Hs. 145225 ESTs 3. 6 430540 AW245422 Hs. 106357 Homo sapiens cDNA : FLJ22105 fis, clone H 3. 6 429747 M87507 Hs. 2490 caspase 1, apoptosis-related cysteine pr 3. 6 453785 Api368236 Hs. 283732 ESTs, Moderately similar to ALU 1-HUMAN A 3. 6 403267 Target Exon 3. 6 440370 AA884000 Hs. 8173 hypothetical protein FU10803 3. 6 447497 AW167254 Hs. 205722 ESTs 3. 6 428600 AW863261 Hs. 242413 hypothetical protein DKFZp434K1421 3. 6 428715 AW293716 Hs. 53126 ESTs 3. 6 416097 BE387371 Hs. 118964 hypothetical protein FLJ20085 3. 6 453438 A1469935 Hs. 22792 ESTs 3. 6 427299 AA830210 Hs. 214263 ESTs, Moderately similar to ALU1 HUMAN A 3. 6 434577 R37316 Hs. 179769 Homo sapiens cDNA : FLJ22487 fis, clone H 3. 6 452785 AL359942 Hs. 296434 erythroid differentiation and denucleati 3. 6 434467 BE552368 Hs. 231853 Homo sapiens cDNA FLJ13445 fis, clone PL 3. 6 435523 T62849 Hs. 11090 membrane-spanning 4-domains, subfamily A 3. 6 418287 A1872319 Hs. 78935 methionineaminopeptidae ; elF-2-associa 36 422156 N34524 gb : yy56d10. s1 Soares_multiple_sclerosis_ 3. 6 441224 AU076964 Hs. 7753 calumenin 3. 6 458072 Api890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 3. 6 435677 AA694142 Hs. 293726 ESTs, Weakly similar to TSGA RAT TESTIS 3. 6 433325 AW206986 Hs. 143905 ESTs 3. 6 420683 AA830168 Hs. 271305 ESTs 3. 6 443206 AB011420 Hs. 9075 sedne/threonine kinase 17a (apoptosis-i 3. 6 454078 AA601518 Hs. 22209 secreted modular calcium-binding protein 3. 6 404584 Target Exon 3. 5 428311 NM_005651 Hs. 183671 tryptophan 2, 3-dioxygenase 3. 5 425922 AL157466 Hs. 162751 Homo sapiens mRNA : cDNA DKFZp761E2423 (f 3. 5 415131 D61119 gb : HUM158C11BOontechhumanfetalbrain 3. 5 412971 AA889628 Hs. 35125 ESTs 3. 5 451593 AF151879 Hs. 26706 CGI-121 protein 3. 5 416427 BE244050 Hs. 79307 Rac/Cdc42 guanine exchange factor (GEF) 3. 5

427809 M26380 Hs. 180878 lipoprotein lipase 3. 5 443303 U67319 Hs. 9216 caspase 7, apoptosis-related cysteine pr 3. 5 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur 3. 5 445936 BE543594 Hs. 61478 hypothetical protein FLJ22329 3. 5 411537 BE073250 gb : MRO-BT0551-060300-102-eOSBT0551 Homo 3. 5 432250 AA452088 Hs. 274170 Opa-interacbng protein 2 3. 5 458438 A1141520 Hs. 151464 ESTs. Weakly similar to ALUC HUMAN ! ! ! ! 3. 5 407253 AA411175 Hs. 141939 ESTs, Moderately similar to S65657 alpha 3. 5 410507 AA355288 Hs. 76064 transitional epithelia response protein 3. 5 412436 AA665089 gb : nu76dO1. s1 NCl_CGAP_Alv1 Homosapiens 3. 5 416933 BE561850 Hs. 80506 small nuclear nbonucleoprotein plypept 3. 5 437681 A1207958 Hs. 166556 Homo sapiens, Similar to TEA domain fami 3. 5 408247 AA053451 Hs. 225632 leucine zipper protein 3 3. 5 440074 AA863045 Hs. 10669 ESTs. Weakly similar to T00050 hypothe6 3. 5 422448 AW372922 Hs. 116774 integrin, alpha 1 3. 5 420676 A1434780 Hs. 4248 vav 2 oncogene 3. 5 417663 R07483 Hs. 180461 ESTs 3. 5 451089 AA903705 Hs. 4190 Homo sapiens cDNA : FLJ23269 fis, done C 3. 5 451446 Al826288 Hs. 171637 hypothetical protein MGC2628 3. 5 414727 BE466904 Hs. 190162 gb : hz28f03. x1 NCI CGAP_GC6 Homo sapiens 3. 5 421778 AA428000 Hs. 283072 actin related protein 2/3 complex, subun 3. 5 427413 BE547647 Hs. 177781 hypothetical protein MGC5618 3. 5 414039 M83221 Hs. 858 v-rel avian reficuloendotheliosis viral 3. 5 456304 A1820973 gb : nc21cO2. y5 NCl_CGAP_Pr1 Homo sapiens 3. 5 449162 Al632740 Hs. 10476 ESTs 3. 5 437774 AW978199 Hs. 291648 ESTs, Weakiy simitar to 138022 hypotheti 3. 5 426827 AW067805 Hs. 172665 methylenetetrahydrofolate dehydrogenase 3. 4 452203 X57522 transporter 1, ATP-binding cassette, sub 3. 4 450325 A1935962 Hs. 26289 ESTs 3. 4 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 3. 4 419726 U50330 Hs. 1274 bone morphogeneuc protein 1 3. 4 417409 BE272506 Hs. 82109 syndecan 1 3. 4 412811 H06382 ESTs 3. 4 430758 T91568 Hs. 270616 ESTs, Moderately similar to A34087 hypot 3. 4 425769 U72513 Hs. 159486 Human RPL13-2 pseudogene mRNA, complete 3. 4 452682 AA456193 Hs. 9071 progesterone membrane binding protein 3. 4 429500 X78565 Hs. 289114 hexabrachion (tenacin C, cytotætin) 3. 4 447674 BE270640 Hs. 19192 cyclin-dependent kinase 2 3. 4 443378 AW392550 Hs. 9280 proteasome (prosome, macropain) subunit, 3. 4 446134 AW161234 Hs. 13993 TBP-like 1 3. 4 418669 U85992 Hs. 87197 Human clone IMAGE : 35527 unknown protein 3. 4 425006 R38685 Hs. 222746 ESTs 3. 4 435256 AF193766 Hs. 13872 cytokinelikeproteinC17 3. 4 453379 AA035261 Hs. 61753 ESTs 3. 4 448224 R48700 Hs. 20733 HomosapienscDNA FW22356hs, cloneH 3. 4 455899 BE155112 gb : PM1-HT0350-151299-003a03 HT0350 Homo 3. 4 422017 Nom-003877 Hs. 110776 STATinducedSTATinhibitor-2 3. 4 417395 BE564245 Hs. 82084 integrin beta 3 binding protein (beta3-e 3. 4 405046 C3000978 : gil9280045ldbjlBABO1579. 1l (ABO 3. 4 423178 A1033140 Hs. 124983 Homo sapiens mRNA ; cDNA DKFZp564C142 (fr 3. 4 455142 AW861840 gb : CMO-CT0337-250200-243-g01 CT0337 Homo 3. 4 418819 AA228776 Hs. 191721 ESTs 3. 4 428289 M26301 Hs. 2253 complement component 2 3. 4 412799 A1267606 gb : aq91hO3. x1 Stanley Frontal SB pool 1 3. 4 403108 ENSP00000241415-: Hypothetical 67. 7 kDa p 3. 4 421637 AF035290 Hs. 106300 Homo sapiens clone 23556 mRNA sequence 3. 4 419373 NM003244 Hs. 90077 TG-interacting factor (TALE family homeo 3. 4 424408 A1754813 Hs. 146428 collagen, type V, alpha 1 3. 4 451061 AW291487 Hs. 213659 ESTs, Weakly similar to KIAAL 357 protein 3. 4 433578 BE336886 Hs. 3416 adipose differentiation-retated protein 3. 4 439867 AA847510 Hs. 161292 ESTs 3. 4 449249 T52285 Hs. 193115 Homo sapiens mRNA for KIAA1764 protein, 3. 4 420982 AW576160 Hs. 100729 KIAA0692 protein 3. 4 440826 AW383618 Hs. 346256 ESTs, Moderately similar to ALU2 HUMAN A 3. 4 427687 AW003867 Hs. 1570 histamine receptor H1 3. 4 400533 ENSP00000209376' : PRED65 protein (Fragmen 3. 3 436314 A1983409 Hs. 189226 ESTs 3. 3 418110 R43523 Hs. 217754 hypothefical protein FU22202 3. 3 448140 AF146761 Hs. 20450 BCM-like membrane protein precursor 3. 3 402229 BE262804 mitochondria'ribosomal protein S2 3. 3 410687 U24389 Hs. 65436 lysyl oxidase-like 1 3. 3 424614 X54486 Hs. 151242 serine (orcysteine) proteinaseinhibito 3. 3 443338 R99575 Hs. 302908 ESTs 3. 3 433062 AK001757 Hs. 281348 hypotheucal protein FLJ10895 3. 3 405303 Target Exon 3. 3 410889 X91662 Hs. 66744 twist (Drosophila) homolog (acrocephalos 3. 3 406673 M34996 Hs. 198253 major histocompatibility complex, class 3. 3 431721 AB032996 Hs. 268044 KIAA1170 protein 3. 3 426746 J03626 Hs. 2057 uridine monophosphate synthetase (orotat 3. 3 425262 D87119 Hs. 155418 GS3955 protein 3. 3 424947 R77952 ESTs, Weakly similar to alternatively sp 3. 3 437634 AW293046 Hs. 255158 ESTs 3. 3 437014 AA808757 Hs. 222531 ESTs, Weakly similar to S59501 interfere 3. 3

411688 AW953440 gb : EST365510 MAGE resequences, MAGB Homo 3. 3 447499 AW262580 Hs. 147674 protocadherin beta 16 3. 3 432625 A1243596 Hs. 94830 ESTs. Moderately similar to T03094 A-kin 3. 3 435644 AA700867 Hs. 269659 ESTs 3. 3 406060 Target Exon 3. 3 425018 BE245277 Hs. 154196 E4Ftranscripbonfætor1 3. 3 450728 AW162923 Hs. 25363 presenilin 2 (Alzheimer disease 4) 3. 3 443105 X96753 Hs. 9004 chondroitin sulfate protezglycan 4 (mela'3. 3 414799 Axa52416 Hs. 77326 insulin-like growth factor binding prote 3. 3 435375 A1733610 Hs. 187832 ESTs 3. 3 432693 AW449630 Hs. 293790 ESTs 3. 3 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 3. 3 422530 AW972300 Hs. 1 18110 bone marrow stromal cell antigen 2 3. 3 448002 Y15227 Hs. 20149 deleted in lymphocytic leukemia, 1 3. 3 433160 AW207002 Hs. 134342 TASP for testis-specific adriamycin sens 3. 3 429125 AA446854 Hs. 271004 ESTs, Weakly similar l0138022 hypotheti 3. 3 452526 W38537 Hs. 280740 hypothetical protein MGC3040 3. 3 416664 H72780 Hs. 20289 ESTs 3. 3 444911 U06117 Hs. 250 xanthene dehydrogenase 3. 3 453544 AA831785 Hs. 171914 Homo sapiens cDNA FW14209 hs, clone NT 3. 3 433042 AW193534 Hs. 281895 Homo sapiens CDNA FU 11660 fis, clone HE 3. 3 444046 A1360834 Hs. 135094 ESTs 3. 3 411373 BE326276 Hs. 8861 ESTs 3. 3 431865 AA521106 Hs. 136375 ESTs, Weakly similar to S65824 reverse t 3. 3 408116 AA251393 Hs. 289052 Homo sapiens, Similar to RIKEN cDNA 5430 3. 3 410006 AW732308 Hs. 57783 eukaryotic translation initiation factor 3. 3 442485 BE092285 Hs. 29724 hypothetical protein FU13187 3. 3 416379 N38857 Hs. 203933 ESTs 3. 3 416308 AW291942 Hs. 23628 3 beta-hydroxy-delta 5-C27-steroid oxido 3. 3 427954 J03060 Hs. 247551 metaxin 1 3. 3 459660 M79082 ESTs 3. 3 419829 Au24228 Hs. 115185 ESTs, ModeratelysimilartoPC4259feni 3. 3 437945 T78519 gb : yd68c08. r1 Soares fetal liver spleen 3. 3 400850 Target Exon 3. 3 457244 AA581385 Hs. 162473 ESTs, Weakly similar to 138022 hypotheti 3. 3 430462 A1584156 Hs. 105640 Homo sapiens, clone IMAGE : 4139775, mRNA, 3. 3 457653 A1820719 Hs. 154662 DnaJ (Hsp40) homolog, subfamilyA, membe 3. 3 431836 AF178532 Hs. 271411 beta-site APP-cleaving enzyme 2 3. 2 440933 A1208217 Hs. 142879 ESTs 3. 2 418079 R40058 Hs. 6911 ESTs 3. 2 414280 BE410769 Hs. 75873 zyxin 3. 2 425295 AA431366 Hs. 37251 ESTs 3. 2 408872 A1476139 Hs. 13291 ESTs 3. 2 416857 AA188775 Hs. 292453 ESTs 3. 2 429599 AA806106 Hs. 123664 ESTs 3. 2 437437 AA226869 hypothetical protein DKFZp762L0311 3. 2 434274 AA628539 Hs. 116252 ESTs, Moderately similar to ALU1 HUMAN A 3. 2 403349 NM 001406 ephrin-B3 3. 2 449385 A1650471 Hs. 347290 ESTs 3. 2 431421 AW969118 Hs. 108144 ESTs, Weakly similar to unnamed protein 3. 2 419865 Nom007020 Hs. 93502 U1-snRNP binding protein homolog (70kD) 3. 2 410700 AA352335 Hs. 65641 hypothetical protein FU20073 3. 2 432044 AW972727 gb : EST384819 MAGE resequences, MAGL Homo 3. 2 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 3. 2 408431 A1338631 Hs. 43266 Homo sapiens cDNA : FU22536 fis, clone H 3. 2 430413 AW842182 Hs. 241392 small inducible cytokine A5 (RANTES) 3. 2 448789 BE539108 Hs. 22051 hypothetical protein MGC15548 3. 2 439332 AW842747 Hs. 300870 Homo sapiens mRNA ; cDNA DKFZp547M072 (fr 3. 2 418030 BE207573 Hs. 83321 neuromedin B 3. 2 428878 AA436884 Hs. 48926 ESTs 3. 2 451527 AF022813 Hs. 26518 transmembrane 4 superfamily member 7 3. 2 426406 Api742501 Hs. 169756 complement component 1, s subcomponent 3. 2 448432 A1783586 Hs. 208575 ESTs 3. 2 433894 A1907682 Hs. 243293 ESTs 3. 2 436210 Al825420 Hs. 197824 ESTs 3. 2 433791 AA719352 Hs. 112718 ESTs 3. 2 450150 Api754391 Hs. 23510 Kruppel-like factor 12 3. 2 427513 A1476318 Hs. 192480 ESTs 3. 2 423789 AK002084 Hs. 132851 hypothetical protein FLJ11222 3. 2 451350 A) 791447 9b : ni13aO5. y5 NCI_CGAP_Co4 Homo sapiens 3. 2 429065 A1753247 Hs. 29643 Homo sapiens cDNA FLJ 13103 fis, clone NT 3. 2 416784 AA334592 Hs. 79914 lumican 3. 2 406851 AA609784 major histocompatibility complex, class 3. 2 428032 AW997704 Hs. 11493 Homo sapiens CDNA FU 13536 fis, clone PL 3. 2 412646 NM 006825 Hs. 74368 transmembrane protein (63kD), endoplasmi 3. 2 432065 AA401039 Hs. 2903 protein phosphatase 4 (formerly X), cata 3. 2 415709 AA649850 Hs. 278558 ESTs 3. 2 422798 R92347 Hs. 34574 ESTs, Weakly similar to ALU 1-HUMAN ALU S 3. 2 437807 A1017875 Hs. 136829 ESTs 3. 2 425171 AW732240 Hs. 16365 ESTs 3. 2 448108 AW300021 Hs. 170685 ESTs 3. 2 402523 C1oo1173-: 9il9743439lgblMF799322l (AF2 3. 2 440146 AW014231 Hs. 90790 Homo sapiens cDNA : FU22930 fis, clone K 3. 2

429415 NM002593 Hs. 202097 procollagen GendopepGdase enhancer 3. 2 422081 AW136820 Hs. 196011 ESTs 3. 2 436258 AW867491 Hs. 107125 plasmalemma vesicle associated protein 3. 2 410886 AW809324 gb : MR4-ST0121-141099-10-G06_1 ST0121 Ho 3. 2 442609 AL020996 Hs. 8518 selenoprotein N 3. 2 416188 BE157260 Hs. 79070 v-myc avian myelocytomatosis viral oncog 3. 2 441544 AW300043 Hs. 127137 ESTs 3. 2 437860 AA333063 Hs. 279898 Homo sapiens cDNA : FW23165 fis, clone L 3. 2 419652 AL157485 Hs. 91973 hypothetical protein 3. 2 443623 AA345519 Hs. 9641 complement component 1, q subcomponenl 3. 2 415198 AW009480 Hs. 943 natural killer cell transcript 4 3. 2 441701 AW339828 Hs. 127497 ESTs 3. 2 426384 Al472078 Hs. 303662 hypothetical protein FLJ13189 (FW13189) 3. 2 420886 AA805453 ESTs, Weakly similar to T29012 hypothefi 3. 2 428896 AW291932 Hs. 98936 ESTs 3. 2 458253 AW296952 Hs. 196802 ESTs 3. 2 456895 AA354771 Hs. 43047 Homo sapiens cDNA FW13585 hs, cione PL 3. 2 434818 AA650097 Hs. 5996 ESTs 3. 2 424278 AK000723 Hs. 144517 hypothetical protein FW20716 3. 2 434131 Al858275 Hs. 143659 ESTs 3. 2 447111 Al017574 Hs. 17409 cysteine-rich protein 1 (intestinal) 3. 1 443021 AA368546 Hs. 8904 Ig superfamily protein 3. 1 416677 T83470 Hs. 334840 ESTs, Moderately similar to 178885 sedn 3. 1 429973 A1423317 Hs. 164680 ESTs 3. 1 422545 X02761 Hs. 287820 fibronectin 1 3. 1 444006 BE395085 Hs. 10086 type I transmembrane protein Fn14 3. 1 420116 NM013241 Hs. 95231 FH11FH2 domain-containing protein 3. 1 401841 NM015113 : Homo sapiens KIAA0399 protein 3. 1 414416 AW409985 Hs. 76084 hypothetical protein MGC2721 3. 1 431019 NM_005249 Hs. 2714 torkhead box G18 3. 1 453707 AW003879 Hs. 126522 Homo sapiens, clone MGC : 16722, mRNA, com 3. 1 432188 A1362952 Hs. 2928 solute carrier family 7 (cationic amino 3. 1 407378 AA299264 Hs. 57776 ESTs, Moderately similar to 138022 hypot 3. 1 430701 A1760B33 Hs. 293971 ESTs 3. 1 429569 AA454993 Hs. 138343 ESTs, Weakly similar to 178885 serine/th 3. 1 458918 H56499 Hs. 252692 ESTs, Weakly similar to 138022 hypotheb 3. 1 439764 T26535 Hs. 22744 hypothetical protein MGC13105 3. 1 452221 C21322 Hs. 288057 hypothetical protein FU22242 3. 1 403969 ENSP00000034663 : Zinc finger protein 131 3. 1 427359 AW020782 Hs. 79881 Homo sapiens cDNA : FW23006 hs, clone L 3. 1 414396 BE548266 Hs. 76057 galactose4epimerase, UDP-3. 1 444153 AK001610 Hs. 10414 hypothetical protein FU10748 3. 1 414403 AW969551 Hs. 76064 ribosomal protein L27a 3. 1 444168 AW379879 gb : RC1-HT0256-081199-011-t01HT0256Homo 3. 1 410595 AW629223 Hs. 64794 zinc finger protein 183 (RING finger, C3 3. 1 444881 Al623288 Hs. 192805 ESTs 3. 1 440381 AA917808 Hs. 190495 ESTs 3. 1 416207 NM 014745 Hs. 79077 Homosapiens, cloneMGC : 2908, mRNA, comp 3. 1 439130 AA306090 Hs. 124707 ESTs 3. 1 457579 AB030816 Hs. 36761 HRAS-like suppressor 3. 1 406736 A ! 254733 Hs. 182426 hbosoma) protein S2 3. 1 420172 AA601122 Hs. 95655 secreted and transmembrane 1 3. 1 428060 AA420616 Hs. 249483 ESTs 3. 1 444143 AW747996 Hs. 160999 ESTs, Moderately similar to A56194 throm 3. 1 409154 U72882 Hs. 50842 interferon-induced protein 35 3. 1 449426 T92251 Hs. 198882 ESTs 3. 1 458760 Api498631 Hs. 111334 femtin, iightpoiypeptide 3. 1 450811 A1739486 Hs. 245497 ESTs 3. 1 425331 AW962128 gb : EST374201MAGEresequences, MAGGHomo 3. 1 445211 BE045601 Hs. 118248 ESTs, WeaklysimilartoYC18 HUMANHYPOT 3. 1 441318 A1078234 Hs. 176130 ESTs 3. 1 450625 AW970107 gb : EST382188 MAGE resequences, MAGK Homo 3. 1 437640 AA764893 Hs. 272155 ESTs, Weakly similar to 138022 hypotheti 3. 1 444672 Z95636 Hs. 11669 laminin, alpha 5 3. 1 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 3. 1 413834 BE296896 Hs. 224179 ESTs. Weakly similar to 138022 hypotheti 3. 1 439755 AW748482 Hs. 77873 B7 homolog 3 3. 1 435520 AA297990 Hs. 9315 HNOEL-iso protein 3. 1 414598 A1094221 Hs. 135150 lung type-I cell membrane-associated gly 3. 1 440948 AW188311 Hs. 128619 ESTs 3. 1 412851 A1826502 Hs. 106149 ESTs 3. 1 417336 R70429 Hs. 81988 disabled (Drosophila) homolog 2 (mitogen 3. 1 417944 AU077196 Hs. 82985 collagen, type V, alpha 2 3. 1 411671 BE049094 ESTs 3. 1 430444 AW296421 Hs. 121035 ESTs 3. 1 425843 BE313280 Hs. 159627 death associated protein 3 3. 1 407721 Y12735 Hs. 38018 dual-specificity tyrosine- (Y)-phosphoryl 3. 1 439093 AA534163 Hs. 5476 Homo sapiens, clone IMAGE : 3530123, mRNA, 3. 1 449523 NM 000579 Hs. 54443 chemokine (C-C motif) receptor 5 3. 1 435664 A1032087 Hs. 269819 ESTs 3. 1 453085 AW954243 KIAA0251 protein 3. 1 430314 AA369601 Hs. 239138 pue-bill colony-enhancing factor 3. 0 447527 Api702896 Hs. 42091 ESTs 3. 0

432682 A1376400 Hs. 159588 ESTs 3. 0 416941 BE000150 Hs. 48778 niban protein 3. 0 455481 AW948317 gb : RCO-MT0015-280300-021-a09 MT0015 Homo 3. 0 445906 N28939 Hs. 13434 Homo sapiens clone 24418 mRNA sequence 3. 0 408716 A1567839 Hs. 151714 Homo sapiens mRNA for KIAA1769 protein, 3. 0 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 3. 0 436443 AW138211 Hs. 128746 ESTs 3. 0 425421 L11669 Hs. 157145 tetracycline transporter-like protein 3. 0 427725 U66839 Hs. 180533 mitogen-activated protein kinase kinase 3. 0 456816 AK001509 Hs. 144391 hypothetical protein FU10647 3. 0 404632 NM022490 : Homo sapiens hypothetical prot 3. 0 411565 AW851728 gb : MR2-CT0222-011199-007-dO6 CT0222 Homo 3. 0 428917 AA437337 Hs. 16689 ESTs 3. 0 424584 H10692 Hs. 13310 ESTs 3. 0 452483 A1903731 Hs. 106357 valosin-containing protein 3. 0 404453 C8000963-: gil6329915ldbjlBM86452. 1l (AB 3. 0 426931 NM-003416 Hs. 2076 zinc finger protein 7 (KOX 4, clone HF. 1 3. 0 455646 BE064420 gb : RC4-BT0311-24119-012c08 BT0311 Homo 3. 0 452188 A1864208 Hs. 176275 ESTs 3. 0 409703 NM 006187 Hs. 56009 2-5'-oligoadenylate synthetase 3 (100 k 3. 0 413922 A1535895 Hs. 221024 ESTs 3. 0 452367 U71207 Hs. 29279 eyes absent (Drosophila) homolog 2 3. 0 434070 AF116652 Hs. 270087 hypothetical protein PR00813 3. 0 406679 AA070786 gb : zm66bO7. r1 Stratagene neuroepithelium 3. 0 414747 U30872 Hs. 77204 centromere protein F (350/400kD, mitosin 3. 0 435472 AW972330 Hs. 283022 triggering receptor expressed on myeloid 3. 0 429612 AF062649 Hs. 252587 pituitary tumor-transforming 1 3. 0 408989 AW361666 Hs. 49500 KIAA0746 protein 3. 0 418365 AW014345 Hs. 161690 ESTs 3. 0 418677 S83308 Hs. 87224 SRY (sex determining region Y)-box 5 3. 0 426765 AA743603 Hs. 172108 nucleoporin 88kD 3. 0 400295'W72838 AI905687 : IL-BT09S190199-019 8T095 Homo 3. 0 429751 M55210 Hs. 214982 laminin, gamma 1 (formerly LAMB2) 3. 0 429940 W25215 gb : zb87aO9. r1 Soares senescent fibroblas 3. 0 412281 A1810054 Hs. 14119 ESTs 3. 0 434898 AW500458 Hs. 29956 KIAA0460 protein 3. 0 424830 AW270580 Hs. 189311 ESTs, Weakly similar to putative p150 [H 3. 0 459727 A1906494 gb : RC-BT113-060499-024 BT113 Homo sapien 3. 0 453900 AW003582 Hs. 226414 ESTs, Weakly similar to ALU8 HUMAN ALU S 3. 0 458729 At364504 Hs. 93967 ESTs, Weakly similar to NBHUC8decorinp 3. 0 402105 C18000230' : gi12585552spp9Y2a1Z257 HU 3. 0 425248 AW957442 Hs. 252766 ESTs 3. 0 440995 T57773 Hs. 10263 ESTs 3. 0 441360 A1091713 Hs. 106597 Homo sapiens, Similar to RIKEN cDNA 1110 3. 0 432692 AW974944 Hs. 200577 ESTs 3. 0 428899 AA744610 Hs. 194431 paladin 3. 0 452811 AA937079 Hs. 118983 hypothetical protein FLJ12150 3. 0 447183 A1554733 Hs. 173182 ESTs 3. 0 429679 NM_006290 Hs. 211600 tumor necrosis factor, alpha-induced pro 3. 0 416505 H66470 Hs. 16004 ESTs 3. 0 420144 AA811813 Hs. 119421 ESTs 3. 0 439184 AW021842 Hs. 16533 myosinphosphatase. targetsubunitt 3. 0 438033 T26483 Hs. 6059 EGF-containing fibulin-like extracellula 3. 0 442476 AF069475 gb : AF069475 Homo sapiens astrocytoma lib 3. 0 441035 A1694309 Hs. 126458 ESTs 3. 0 458810 BE407125 Hs. 231510 ESTs 3. 0 435046 AA662772 Hs. 174330 ESTs, Weakly similar to ALU1HUMANALUS 3. 0 414271 AK000275 Hs. 75871 protein kinase C binding protein 1 3. 0 450879 A1742685 Hs. 210347 ESTs 3. 0 454036 AA374756 Hs. 93560 Homo sapiens mRNA for KIAA1771 protein, 3. 0 403780 C4001759 : gi133250spP19474R052 HUMAN 3. 0 411543 AW851248 gb : IL3-CT0220-160200-066-F01 CT0220 Homo 3. 0 440351 AF030933 Hs. 7179 RAD1 (S. pombe) homolog 3. 0 452139 AA099969 Hs. 16331 Homo sapiens cDNA : FU21482 fis, clone C 3. 0 449433 A1672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 3. 0 413945 NM000591 Hs. 75627 CD14 antigen 3. 0 433681 A1004377 Hs. 200360 Homo sapiens cDNA FLJ13027 fis, clone NT 3. 0 422605 H16646 Hs. 118666 hypthetica'proteinPP591 3. 0 443502 A1074528 Hs. 133949 ESTs 3. 0 410781 A1375672 Hs. 165028 ESTs 3. 0 449428 A1651280 Hs. 195685 ESTs 3. 0 436671 AW137159 Hs. 146151 ESTs 3. 0 TABLE 16B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408432 10586671 AW195262R27868AW811262 410886 1225822_1 AW809324 BE144977 BE144956 411537 1248899 1 BE073250 BE073378 BE073379 AW850533 AW850529 411543 1249127_1 AW851248 AW851425 AW850805 AW851021 AW850905

411565 1249756_1 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727AW851658 AW851617 AW851628 411671 125369_1 BE049094 M700765 H86770 M094646 R02483 C03868 N56170 411688 1254076_1 AW953440 T08189 AW857085 412436 129439J AA665089AA135130AA484059AA102419AW877765 412799 132817 1 Al267606M121045M126521 412811 1329431 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 A1424991 AI693507 AI863108 AA599060 A1091148 AA598689 R39887 AA813482 AW016452 H06383 R41807 A1364268 AA620528 A1241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734 414372 143909 1 AA143654 AW753140 AA213770 AW970865 AA569075 AA492132 415131 1523680 t D61119 D81508 D81734 415688 154643 1 AA166963 AW971218 AA493942 416871 1626761 1 H98716 N90792 N24283 416913 163001J AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499 419896 1883662_1 Z99362 Z99363 420886 1973441 AA805453AA281379 422156 212379_1 N34524 AA305071 AW954803 AA502335 At433430 At203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512 Al334966 W32951 H62656 H53902 R88904 AW835732 423713 231290 1 AW754182 AW754198 AA329983 424009 234177 1 F11690AW965370M333536D30830 424947 245247 1 R77952 AA348809 AW959960 AW959962 AI565552 AW070702 AA973910 R85973 425331 250199 1 AW962128 AA355353 AA427363 429163 300543_1 AA884766 AW974271 AA592975 AA447312 429940 3108841 W25215AA461079AA461391 430968 3262691 AW972830AA527647AA489820AA570362 432044 340773_1 AW972727 M524329 AW972733 432363 345469_1 AA534489 AW970240 AW970323 435542 407744_1 AA687376 H74234 AW975503 437437 43709_1 M226869 M296516 AW959753 AA186390 AL359619 AA356195 AAi48427 R22748 A1033624 BE548853 H95327 AW579751 BE561649 AA397533 BE617136 M236444 T89946 AA247450 N55777 W38725 AI743846 AI808406 AA922229 A10514&4 W04713 RI 1251 W19656 A1042319 AA489276 A1224533 H 437945 44580 1 T78519H59898U72516 439518 47334 1 W76326 AF086341 W72300 439566 47387 1 AF086387 W77884 W72711 439710 47550_1 AF086543W96291 W96225 442476 543547 1 AF069475 AF069477 AF069476 444168 593829_1 AW379879AI126285 H12014 449625 8113 1 NM 014253 AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760 N48674 A1375997 R45432 D59344 A1203107 F07491 R35360 R25094 A1913631 A1498402 T61382 A1016320 N45526 T61415 AA331486 450166 82677_1 M429504 R41904 AA279467 H09648 AA007236 450375 83327J AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532 AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 AIt61014 AA099554 R69067 450506 836_1 NM_004460 U09278 U76833 AW630055 AW471133 C02434 W45237 AW793518 BE070112 A1587479 Al624429AW190535 Al446661 Al478772 AW022667 AA528235 AA599775 AW613820 A1435793 AW594230 Al051768 Al200109 A1680296 M436611 AW609728 W42634 A1682584 AA405569 A1685653 AWO 450625 84032_1 AW970107M513951 M010406 451129 859870 1 BE072881 BE072946 A1762181 451350 866945_1 Al791447 Al791327 AW886809 452203 903 2 X57522 AW295947 A1346197 A1304693 L21205 L21206 L21207 L21208 L21204 NM 000593 F06770 F12630 X57521 R18264 T74462 AA346259 AW602508 AA904076 F08426 H23432 AA313737 AA393782 M78052 AA847441 AA487637 AA135770 AA353161 A1819778 AA054458 A1346733 AW361447 A14 453085 94851-1 AW954243 AA829930 AA412478 AA828434 AA814538 A1927418 A1192435 W52897 AA443666 AA031913 AI683306 AA918481 AI183314 D83907 Al206832 M876122 D83336 D83838 D82533 At761290 Al191125 Al143749 AW771909 A1241436 A1767267 W56507 AA847787 AA568692 T10502 A1247870 453331 96214_1 A1240665 T53681 N77468 H51833 M147247 R75732 Cl 9450 R73999 A1095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292 R31981 H12498 H02668 AA035018 R75957 At803329 R27528 R36203 A1809932 AI808765 R78948 AA411449 AA976929 AI378760 AI378620 T48870 R7390 453682 977454_1 T79703 T96307 AL079725 454860 1237732_1 AW835767AW835537BE160187 455142 1254887 1 AW861840 AW858329 AW858192 AW858189 AW858224 AW858351 455481 1293182 1 AW948317 AW948322 AW948329 AW948316 AW948298 AW948330 AW948325 AW948324 455646 1348557 1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 455899 1381547 1 BE155112 8E155154 BE155087 BE155247 BE155499 BE155367 BE155452 456304 176820 A1820973 A1734077 A1820984 AA225796 AA225060 AA2251 01 457876 42814_2 AI821940 N67106 AI744264 AA808846 AA643417 AA643416 Z70715 TABLE 16C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. et refers to the publication entitled'The DNA sequence of human chromosome 2Y Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_posi60n : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 400533 6981826 Minus 277132-277595 400850 1927150 Minus 4506-4691 401454 9186923 Minus 114659-114832 401841 7684597 Plus 89868-90006, 91920-92085 402082 8117478 Minus 190046-190183 402105 8131588 Minus 22856-24055 402229 9965022 Minus 15739-15951, 16166-16779 402239 7690131 Plus 38175-38304, 42133-42266 402274 2935596 Plus 5604-6527 402523 9798518 Minus 18729-19283 402604 9909420 Plus 20393-20767

402855 9662953 Minus 59763-59909 403011 6693597 Minus 3468-3623 403108 8980955 Plus 93253-93667 403267 7887182 Plus 116078-121885 403349 8569773 Minus 167815168374 403361 8570313 Minus 112496-112687 403481 9965004 Plus 93496-93633 403696 3135242 Minus 143467-143634 403780 8076989 Plus 93160-93409 403849 7708855 Plus 95043-96519 403961 7596976 Minus 110393-110603 403969 8569909 Plus 31237-31375, 32405-32506 404209 5006246 Minus 11247-11514 404407 7329316 Minus 4815¢48499 404453 7657714 Plus 27768-29179 404584 9857511 Plus 138651-139153 404632 9796668 Plus 45096-45229 405046 7596829 Minus 4373-4528 405141 8980911 Plus 99861-100054 405303 2078453 Minus 130607-130802 405348 2914717 Minus 43310-43462 405558 1621110 Plus 4502-4644, 5983-6083 405605 5836195 Minus 117070-117270 406038 8389537 Plus 37764-37877 406060 6899623 Minus 20339-20746 406478 9857502 Plus 68314-68523, 68853-68950 TABLE 17A : ABOUT 1040 GENES UP-REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL ADULT TISSUES Table 17A lists about 1040 genes up-regulated in glioblastoma multiforma (GBM) compared to normal normal adult tissues. These were selected from 59680 probesets on the Affymetix/Eos Hu03 GeneChip array such that the ratio of"average'glioblastoma to'average'normal tissues was greater than or equal to 3. 0. The'average"GBM level was set to the 85m percentile amongst various GBM tumors. The'average'normal tissue level was set to the 85b pencen61e amongst various non-malignant adult tissues. n order to remove gene-specific background levels of non-specific hybridization, the 10' percenfile value amongst the various non-maiignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene tUe RI : Ratio of GLIOBLASTOMA MULTIFORMA compared to NORMAL ADULT TISSUES Pkey ExAccn UnigenelD Unigene Title R1 431917 D16181 Hs. 2868 peripheral myelin protein 2 57. 9 428321 A1699994 Hs. 2868 peripheral myelin protein 2 50. 1 427343 A1880044 Hs. 176977 protein kinase C binding protein 2 49. 6 413472 BE242870 Hs. 75379 solute carrier family 1 (gtiai high affi 43. 9 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 42. 9 435147 AL133731 Hs. 4774 Homo sapiens mRNA ; cDNA DKFZp761 C1712 (f 42. 5 430838 N46664 Hs. 169395 hypotheticalprotein FLJ12015 37. 9 418375 Nom003081 Hs. 84389 synaptosomal-asociated protein, 25kD 37. 1 449494 AW237014 Hs. 315369 Homo sapiens cDNA : FLJ23075 fis, clone L 37. 0 425088 AA663372 Hs. 169395 hypothetical protein FLJ12015 32. 7 425842 A1587490 Hs. 159623 NK-2 (Drosophila) homolog B 32. 4 419078 M93119 Hs. 89584 insulinoma-associated 1 32. 1 423849 AL157425 Hs. 133315 Homo sapiens mRNA ; cDNA DKFZp761J1324 (f 29. 9 409389 AB007979 Hs. 301281 Homo sapiens mRNA, chromosome 1 specific 28. 8 413333 M74028 Hs. 75297 fibroblast growth factor I (acidic) 28. 5 417183 R52089 Hs. 172717 ESTs 27. 6 426325 D28114 Hs. 169309 myelin-associated oligodendrocyte basic 27. 6 412733 AA984472 Hs. 74554 KIAA0080 protein 25. 9 422656 AI870435 Hs. 1569 LIM homeobox protein 2 25. 6 436878 BE465204 Hs. 47448 ESTs 24. 9 437204 AL110216 Hs. 22826 ESTs, Weakly similar to 155214 salivary 24. 3 429007 D80642 gb : HUM092E09B Human fetal brain (TFujiwa 23. 1 429276 AF056085 Hs. 198612 G protein-coupled receptor 51 23. 1 409395 U46745 Hs. 336678 dystrobrevin, alpha 23. 0 435708 A1362949 Hs. 75169 ESTs 22. 5 453392 U23752 Hs. 32964 SRY (sex determining region Yybox 11 22. 2 431941 AK000106 Hs. 272227 Homo sapiens cDNA FW20099 hs, clone CO 22. 1 418110 R43523 Hs. 217754 hypothetical protein FLJ22202 22. 0 416829 AB013805 Hs. 80220 catenin (cadherin-associated protein), d 21. 7 444513 AL120214 Hs. 7117 glutamate receptor, ionotropic, AMPA 1 20. 9 433551 A1985544 Hs. 12450 protocadherin 9 19. 8 452744 Api267652 Hs. 246107 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 19. 1 425057 AA826434 Hs. 1619 achaete-scute complex (Drosophila) homol 19. 0 429903 AL134197 Hs. 93597 cyclin4ependentkinaeS, regulatorysu 19. 0 447004 AW296968 Hs. 157539 ESTs 18. 6 425048 H05468 Hs. 164502 ESTs 18. 2 427897 NM_017413 Hs. 303084 apelin ; peptide ligand for APJ receptor 18. 0 421264 AL039123 Hs. 103042 microtubule-associated protein 18 18. 0 453642 A1370936 Hs. 34074 dipeptidylpeptidase VI 17. 8 424140 Z48051 Hs. 141308 myelin oligodendrocyte glycoprotein 17. 7 444471 AB020684 Hs. 11217 KIAA0877 protein 17. 6 441350 AB020690 Hs. 7782 paraneoplastic antigen MA2 17. 2 430691 C14187 Hs. 103538 ESTs 16. 7

433800 A1034361 Hs. 135150 lung type-I cell membrane-associated gly 16. 6 424581 M62062 Hs. 150917 catenin (cadhedn-associated protein), a 16. 6 408562 AI436323 Hs. 31141 Homo sapiens mRNA for KIAA1568 protein, 16. 5 423853 AB011537 Hs. 133466 slit (Drosophila) homolog1 16. 4 431019 Nom-005249 Hs. 2714 forkhead box G1B 16. 4 449539 W80363 Hs. 58446 ESTs 16. 4 450133 AW969769 Hs. 105201 ESTs 16. 1 425799 T08133 Hs. 182906 Homo sapiens MRNA for KIAAL 872 protein, 16. 0 447359 NM012093 Hs. 18268 adenylate kinase 5 15. 4 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 15. 3 459516 A1049662 Hs. 246858 EST 14. 9 456759 BE259150 Hs. 127792 delta (DrosophilaFlike3 14. 7 429466 M85835 Hs. 12827 ESTs 14. 7 439979 AW600291 Hs. 6823 hypothetical protein FW10430 14. 7 443785 AW449952 Hs. 190125 basic-helix-loop-helix-PAS protein 14. 6 439415 F05538 Hs. 4273 ESTs 14. 5 408604 D51408 Hs. 21925 ESTs 14. 5 444378 R41339 Hs. 47860 neurotrophic tyrosine kinase, receptor, 14. 3 428392 H10233 Hs. 2265 secretory granule, neuroendocdne protei 14. 0 418738 AW388633 Hs. 6682 solutecanierfamily7, (cationicamino 14. 0 409799 D11928 Hs. 76845 phosphoserine phosphatase-like 13. 9 439239 A1031540 Hs. 235331 ESTs 13. 8 428342 A1739168 Homo sapiens cDNA FW13458 hs, clone PL 13. 7 448595 AB014544 Hs. 21572 KIAA0644 gene product 13. 6 441285 NM002374 Hs. 167 microtubule-asociated protein 2 13. 5 428982 NM005097 Hs. 194704 leucine-rich, glioma inactivated 1 13. 4 441440 A1807981 Hs. 30495 ESTs 13. 0 412959 D87458 Hs. 75090 KIAA0282 protein 12. 8 413597 AW302885 Hs. 117183 ESTs 12. 8 441016 AW138653 Hs. 25845 ESTs 12. 7 418338 NM 002522 Hs. 84154 neuronal pentraxin I 12. 6 423419 R55336 Hs. 23539 ESTs 12. 6 445495 BE622641 Hs. 38489 ESTs, Weakly similar to 138022 hypotheb 12. 6 441497 R51064 Hs. 23172 ESTs 12. 4 424893 AW295112 Hs. 153648 Homo sapiens CDNA FU 13303 fis, clone OV 12. 2 453941 U39817 Hs. 36820 Bloom syndrome 12. 2 427701 AA411101 Hs. 243886 nuclear autoantigenic sperm protein (his 12. 2 446782 A1653048 Hs. 144006 ESTs 12. 1 437268 A1754847 Hs. 227571 regulator of G-protein signalling 4 12. 1 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAA1330 protein 11. 9 448302 At480208 Hs. 182906 Homo sapiens mRNA for KIAA1872 protein, 11. 9 407034 U84540 gb : Human dystrobevin isoform DTN-3 (DTN 11. 9 449625 NM 014253 odz (odd Ozlten-m, DTosophila) homolog 1 11. 7 451099 R52795 Hs. 25954 intedeukin 13 receptor, alpha 2 11. 7 424432 AB037821 Hs. 146858 protocadhedn 10 11. 6 451996 AW514021 Hs. 245510 ESTs 11. 4 423678 AW963357 Hs. 7847 ESTs 11. 4 445041 T64183 Hs. 282982 solute carrier 11. 3 442613 A1004002 Hs. 130522 Kv channel-interacting protein 1 11. 2 419721 NM001650 Hs. 288650 aquaporin 4 11. 2 446711 AF169692 Hs. 12450 protocadherin 9 11. 1 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) 11. 0 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 10. 7 428728 NM016625 Hs. 191381 hypothetical protein 10. 6 415849 R20529 Hs. 6806 ESTs 10. 6 447198 D61523 Hs. 283435 ESTs 10. 5 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 10. 3 435793 AB037734 Hs. 4993 KIAA1313 protein 10. 3 409049 A1423132 Hs. 146343 ESTs 10. 2 449611 A1970394 Hs. 197075 ESTs 10. 2 402604 Target Exon 10. 1 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 10. 0 440435 AL042201 Hs. 21273 transcription factor NYD-spl0 10. 0 438080 AA777381 Hs. 291530 ESTs, Weakly similar to ALUC_HUMAN ! ! ! ! 10. 0 419271 N34901 Hs. 238532 ESTs 9. 9 426344 H41821 Hs. 322469 transcriptional activator of the c-fos p 9. 8 449605 AW138581 Hs. 198416 ESTs 9. 8 408081 AW451597 Hs. 167409 ESTs 9. 8 452526 W38537 Hs. 280740 hypothetical protein MGC3040 9. 8 411305 BE241596 Hs. 69547 myelin basic protein 9. 8 443455 AB001025 Hs. 9349 ryanodine receptor 3 9. 8 427540 R12014 Hs. 20976 ESTs 9. 7 424790 AL119344 Hs. 13326 ESTs, Weakly similar to 2004399A chromos 9. 7 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 9. 6 452461 N78223 Hs. 108106 transcription factor 9. 6 449433 A1672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 9. 6 454027 R40192 Hs. 21527 HumanDNAsequencefromcloneGS1-115M3 9. 5 439199 R40373 Hs. 26299 ESTs 9. 5 433896 AW294729 Hs. 274461 ESTs 9. 3 416072 AL110370 Hs. 79000 growth associated protein 43 9. 3 444119 R41231 Hs. 184261 ESTs, Weakly similar to T26686 hypotheti 9. 2 435624 AF218942 Hs. 24889 formin 2 9. 2 412788 AA120960 Hs. 198416 ESTs 9. 2

409902 A1337658 Hs. 156351 ESTs 9. 2 427304 AA761526 Hs. 163853 ESTs 9. 2 429918 AW873986 Hs. 119383 ESTs 9. 1 442910 A1365130 Hs. 11307 ESTs, Weakly similar to T19326 hyptheti 9. 1 425187 AW014486 Hs. 22509 ESTs 9. 1 436954 AA740151 Hs. 130425 ESTs 9. 1 442710 A1015631 Hs. 23210 ESTs 9. 1 411078 A1222020 Hs. 182364 CocoaCrisp 9. 0 438209 AL120659 Hs. 6111 aryl-hydrocarbon receptor nuclear transl 9. 0 437036 A1571514 Hs. 133022 ESTs 9. 0 448672 Api955511 Hs. 225106 ESTs 9. 0 451952 AL120173 Hs. 301663 ESTs 8. 9 448743 AB032962 Hs. 21896 KIAA1136 protein 8. 9 412068 S72043 Hs. 73133 metallothionein 3 (growth inhibitory fac 8. 9 439451 AF086270 Hs. 278554 heterochromatin-iike protein 1 8. 8 419088 Al538323 Hs. 52620 integrin, beta 8 8. 8 445873 AA250970 Hs. 251946 poly (A)-binding protein, cytoplasmic 1-1 8. 8 410102 AW248508 Hs. 279727 ESTs ; homoloque of PEM-3 [Ciona savignyi 8. 8 449571 AW016812 Hs. 200266 ESTs 8. 7 425354 U62027 Hs. 155935 complement component 3a receptor 1 8. 7 452355 N54926 Hs. 29202 G protein-coupled receptor 34 8. 7 410276 Api554545 Hs. 68301 angiopoietin-2 8. 7 435501 AW051819 Hs. 129908 KIAA0591 protein 8. 6 407728 AW071502 Hs. 175931 ESTs 8. 6 415293 R49462 Hs. 106541 ESTs 8. 6 416857 AA188775 Hs. 292453 ESTs 8. 6 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypotheb 8. 5 450375 AA009647 a disintegrin and metalloproteinae dorna 8. 5 413063 AL035737 Hs. 75184 chitinae3-like1 (carblageglycoprote 8. 4 438380 T06430 Hs. 6194 chondroiún sulfate proteoglycan BEHAB/b 8. 4 421659 NM 014459 Hs. 106511 protocadherin 17 8. 4 418097 R45137 Hs. 21868 ESTs 8. 3 429183 AB014604 Hs. 197955 KIAA0704 protein 8. 2 424945 AI221919 hypothetical protein FU10582 8. 2 455601 AI368680 Hs. 816 SRY (sex determining region Y)-box 2 8. 2 453884 AA355925 Hs. 36232 KIAA0186 gene product 8. 2 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-0-sulfot 8. 1 436887 AW953157 Hs. 193235 hypothetical protein DKFZp547D155 8. 1 431721 AB032996 Hs. 268044 KIAA1170 protein 8. 1 417160 N76497 Hs. 1787 proteolipid protein 1 (Pelizaeus-Meabac 8. 1 409041 AB033025 Hs. 50081 Hypothetical protein, XP 051860 (KIAA119 8. 1 424085 NM002914 Hs. 139226 replication factor C (activator 1) 2 (40 8. 1 436039 AW023323 Hs. 121070 ESTs 8. 0 449444 AW818436 Hs. 23590 solute carrier family 16 (monocarboxylic 8. 0 427463 AA442224 Hs. 97900 ESTs 8. 0 440184 AB002297 Hs. 7022 dedicator of cyto-kinesis 3 7. 9 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 7. 8 451621 A1879148 Hs. 26770 fatty acid binding protein 7, brain 7. 7 419929 U90268 Hs. 93810 cerebral cavemous malformations 1 7. 7 419544 A1909154 gb : QV-BT200-010499-007 BT200 Homo sapien 7. 7 448555 A1536697 Hs. 159863 ESTs 7. 7 414372 AA143654 gb : zo65aO2. r1 Stratagene pancreas (93720 7. 7 438527 A1969251 Hs. 115325 RAB7. member RAS oncogene family-like 1 7. 7 400293 N51002 Hs. 306480 HomosapiensmRNA ; cDNADKFZp761E2112 (f 7. 7 420362 U79734 Hs. 97206 huntingtininteractingproteini 7. 6 430132 AA204686 Hs. 234149 hypothetical protein FU20647 7. 5 448543 AW897741 Hs. 21380 HomosapiensmRNA ; cDNA DKFZp586P1124 (f 7. 5 436140 W87355 Hs. 269587 ESTs 7. 4 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 7. 4 446372 AB020644 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 7. 4 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 7. 4 410434 AF051152 Hs. 63668 toll-like receptor 2 7. 4 454048 H05626 Hs. 6921 ESTs 7. 4 441523 AW514263 Hs. 301771 ESTs, Weakly similar to ALUF HUMAN ! ! ! ! 7. 4 440074 AA863045 Hs. 10669 ESTs, Weakly similar to T00050 hypotheti 7. 4 438330 AW450572 Hs. 257316 ESTs 7. 4 433556 W56321 Hs. 111460 ca'cium/calmodulin-dependentproteinkin 7. 3 434808 AF155108 Hs. 256150 Homosapiens, SimilartoRIKENcDNA2810 7. 3 445900 AF070526 Hs. 125036 Homo sapiens clone 24787 mRNA sequence 7. 3 402855 NM001839' : Homo sapiens calpnin 3, acid 7. 2 422960 AW890487 Hs. 63984 cadherin 13, H-cadherin (heart) 7. 2 439772 AL365406 Hs. 10268 Homo sapiens mRNA full length insert cDN 7. 2 433447 U29195 Hs. 3281 neuronal pentraxin 11 7. 2 412709 AL022327 Hs. 74518 KIAA0027 protein 7. 2 445745 A8007924 Hs. 13245 KIAA0455 gene product 7. 2 447101 N72185 Hs. 44189 ESTs 7. 2 448935 AL078596 Hs. 22591 nuclear receptor subfamily 2, group E, m 7. 1 409248 AB033035 Hs. 51965 KIAA1209 protein 7. 1 452785 AL359942 Hs. 296434 erythroid differentiation and denucleati 7. 1 424998 U58515 Hs. 154138 chi6nae3-like2 7. 1 436607 AW661783 Hs. 211061 ESTs 7. 1 447197 R36075 gb : yh88bO1. si Soares placenta Nb2HP Homo 7. 1 419249 X14767 Hs. 89768 gamma-aminobutyhcacid (GABA) A recepto 7. 1

416111 AA033813 Hs. 79018 chromatin assembly factor 1, subunit A (7. 1 421633 AF121860 Hs. 106260 sorting nexin 10 7. 0 428976 AL037824 Hs. 194695 ras homolog gene family, member 1 7. 0 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 7. 0 408096 BE250162 Hs. 83765 dihydrofolate reductase 7. 0 426269 H15302 Hs. 168950 Homo sapiens mRNA ; cDNA DKFZp566A1046 (f 6. 9 439978 BE139460 Hs. 124673 Homo sapiens cDNA FLJ11477 hs, cione HE 6. 9 439570 T79925 Hs. 269165 ESTs, Weakly similar to ALU1 HUMAN AlU S 6. 9 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (CIEBP), 6. 9 415279 F04237 Hs. 1447 glial fibrillary acidic protein 6. 9 456965 AW131888 Hs. 172792 ESTs. Weakly similar to hypothetical pro 6. 9 447773 A1423930 Hs. 36790 ESTs, Weakly similar to putative p150 [H 6. 9 429927 NM001115 Hs. 2522 adenylate cyclase 8 (brain) 6. 9 447499 AW262580 Hs. 147674 protocadherin beta 16 6. 8 414696 AF002020 Hs. 76918 Niemann-Pick disease, type C1 6. 8 441255 R06350 Hs. 171635 ESTs 6. 8 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 6. 8 439566 AF086387 gb : Homo sapiens full length insert cDNA 6. 8 435191 R15912 Hs. 4817 Homosapienscbne 24461 mRNAsequence 6. 8 420285 AA258124 Hs. 293878 ESTs, Moderately similar to ZN91 HUMAN Z 6. 8 430968 AW972830 gb : EST384925 MAGE resequences, MAGL Homo 6. 8 458332 Al000341 Hs. 220491 ESTs 6. 8 449048 Z45051 Hs. 22920 similar to S68401 (cattle) glucose induc 6. 7 413627 BE182082 Hs. 246973 ESTs 6. 7 415079 R43179 Hs. 22895 hypothetical protein FLJ23548 6. 7 418677 S83308 Hs. 87224 SRY (sex determining region Y)-box 5 6. 7 432281 AK001239 Hs. 274263 hypothetical protein FU10377 6. 7 425741 AF052152 Hs. 159412 Homo sapiens clone 24628 mRNA sequence 6. 7 421141 AW117261 Hs. 125914 ESTs 6. 6 408829 NM 006042 Hs. 48384 heparan sulfate (glucosamine) 3-0-sulfot 6. 6 432154 A1701523 Hs. 112577 ESTs 6. 6 425202 AW962282 Hs. 152049 ESTs, Weakly similar to 138022 hyptheti 6. 6 434164 AW207019 Hs. 148135 serine/threonine kinase 33 6. 6 407182 AA312551 Hs. 230157 ESTs 6. 6 445034 AW293376 Hs. 143659 ESTs 6. 6 410909 AW898161 Hs. 53112 ESTs, Moderately similarto ALUB HUMAN A 6. 6 441102 AA973905 intermediate filament protein syncoilin 6. 6 452834 A1638627 Hs. 105685 KIAA1688 protein 6. 6 429239 AA448419 Hs. 45209 ESTs 6. 6 414175 A1308876 Hs. 103849 hypotheticalproteinDKFZp761D112 6. 5 449300 A1656959 Hs. 346514 ESTs 6. 5 446727 AB011095 Hs. 16032 KIAA0523 protein 6. 5 429250 H56585 Hs. 198308 tryptophan rich basic protein 6. 5 420560 AW207748 Hs. 59115 ESTs 6. 5 448321 NM005883 Hs. 20912 adenomatous polyposis coli like 6. 5 441390 A1692560 Hs. 131175 ESTs 6. 5 407168 R45175 Hs. 117183 ESTs 6. 4 447414 D82343 Hs. 74376 neuroblastoma (nerve tissue) protein 6. 4 407235 D20569 Hs. 169407 SAC2 (suppressor of actin mutations 2, y 6. 4 433597 AA708205 Hs. 100343 ESTs 6. 4 414528 AA148950 Hs. 188836 ESTs 6. 4 414214 D49958 Hs. 75819 glycoprotein M6A 6. 4 446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 6. 4 407896 D76435 Hs. 41154 Zic family member 1 (odd-paired Drosophi 6. 4 440152 AB002376 Hs. 7006 KIAA0378 protein 6. 4 453785 At368236 Hs. 283732 ESTs. Moderately similar to ALU1 HUMAN A 6. 3 412530 AA766268 Hs. 266273 hypothetical protein FU13346 6. 3 448902 Z45998 Hs. 22543 Homo sapiens mRNA ; cDNA DKFZp76111912 (f 6. 3 452799 A1948829 Hs. 213786 ESTs 6. 3 425523 AB007948 Hs. 158244 KIAA0479 protein 6. 3 444396 T65213 Hs. 4257 ESTs 6. 3 422094 AF129535 Hs. 272027 F-box only protein 5 6. 3 420649 A1866964 Hs. 124704 ESTs, Moderately similar to S65657 alpha 6. 3 424028 AF055084 Hs. 153692 Homo sapiens cDNA FW 14354 hs, clone Y7 6. 3 447350 A1375572 Hs. 172634 ESTs 6. 2 448148 NM 016578 Hs. 20509 HBV pX associated protein-8 6. 2 436936 AL134451 Hs. 197478 ESTs 6. 2 448243 AW369771 Hs. 52620 integrin, beta 8 6. 2 414727 BE466904 Hs. 190162 gb : hz28fO3. x1NCI CGAP_GC6 Homo sapiens 6. 2 420608 BE548277 Hs. 103104 ESTs 6. 2 422949 AA319435 gb : EST21657 Adrenal gland tumor Homo sap 6. 2 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 6. 1 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 6. 1 423361 AW170055 Hs. 47628 ESTs 6. 1 417417 F05745 Hs. 89512 ATPase, Ca transporting, plasma membrane 6. 1 447072 D61594 Hs. 17279 tyrosylprotein suffotransferase 1 6. 1 415651 Api207162 Hs. 3815 stathmin-like-protein RB3 6. 0 418030 BE207573 Hs. 83321 neuromedin 8 6. 0 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxylating ; 6. 0 417873 BE266659 Hs. 293659 Homosapiens, SimilartoRIKENcDNAA430 6. 0 429900 AA460421 Hs. 30875 ESTs 6. 0 416439 AA180363 Hs. 118769 ESTs 6. 0 439845 AL355743 Hs. 56663 Homo sapiens EST from clone 41214, full 6. 0

425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ng finge 6. 0 439518 W76326 gb : zd60dO4. r1 Soares_fetal heart_NbHH19W 6. 0 426919 AL041228 ELAV (embryonic lethal, abnormal vision, 6. 0 440492 R39127 Hs. 21433 hypotheticalprotein DKFZp547J036 5. 9 432328 A1572739 Hs. 195471 6-phosphofructo-2-kinaselfructose-2. 6-bi 5. 9 444190 A1878918 Hs. 10526 cysteine and glycine-rich protein 2 5. 9 425984 AW836277 Hs. 165636 hypotheticalprotein DKFZp761C07121 5. 9 425977 R15138 Hs. 165570 Homosapiensclone25052mRNAsequence 5. 9 449318 AW236021 Hs. 78531 Homo sapiens, Similar to RIKEN cDNA 5730 5. 9 457465 AW301344 Hs. 122908 DNA replication factor 5. 9 453362 H14988 Hs. 107375 ESTs 5. 9 453924 R49295 Hs. 24886 ESTs 5. 9 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 5. 8 433701 AW445023 Hs. 15155 ESTs 5. 8 412777 A1335773 Hs. 270123 ESTs 5. 8 419723 AL120193 Hs. 339810 longevity assurance (LAG1, S. cerevisiae 5. 8 438054 AA776626 Hs. 169309 ESTs 5. 8 416427 BE244050 Hs. 79307 Rac/Cdc42guanine exchange factor (GEF) 5. 8 400292 AA250737 Hs. 72472 BMP-RiB 5. 8 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Orcadian Oscitiat 5. 8 453313 BE005771 Hs. 153746 hypothetical protein FU22490 5. 8 430188 AL049242 Hs. 234794 Homo sapiens mRNA ; cDNA DKFZp564B083 (fr 5. 8 411252 AB018549 Hs. 69328 MD-2 protein 5. 8 448986 H42169 Hs. 347310 hypothetical protein FU14627 57 440052 Al633744 Hs. 195648 ESTs, Wealdy similar to 138022 hypotheb 5. 7 419704 AA429104 Hs. 45057 ESTs 5. 7 420077 AW512260 Hs. 87767 ESTs 5. 7 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 5. 7 436511 AA721252 Hs. 291502 ESTs 5. 7 424560 AA158727 Hs. 150555 protein predicted by clone 23733 5. 7 423346 A1267677 Hs. 127416 synaptoianin 1 5 7 439249 AF086060 Hs. 170053 G-protein coupled receptor 88 5. 7 428588 F12101 Hs. 185701 HomosapiensmRNAfulllengthinsencDN 5. 7 450927 A1807804 Hs. 134342 TASP for tesfis-specific addamycin sens 5. 7 451752 AB032997 Hs. 26966 KIAA1171 protein 5. 7 458814 A1498957 Hs. 170861 ESTs, Weakly similar to Zi 95_HUMAN ZI NC 5. 6 416406 D86961 Hs. 79299 lipoma HMGI C fusion partner-like 2 5. 6 448275 BE514434 Hs. 20830 kinesin-like 2 5. 6 413492 087470 Hs. 75400 KIAA0280 protein 5. 6 444600 R41398 Hs. 6996 ESTs 5. 6 421988 AW450481 Hs. 161333 ESTs 5. 6 443297 A1049864 Hs. 133029 ESTs 5. 6 433244 AB040943 Hs. 271285 KIAA1510 protein 5. 5 458809 AW972512 Hs. 20985 sin3-associated polypeptide, 30kD 5. 5 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 5. 5 447458 A1741082 Hs. 158961 ESTs 5. 5 436643 AA757626 Hs. 10941 ESTs, Weakly similar to IPP11HUMAN PROTE 5. 5 407886 AW969688 Hs. 100826 ESTs 5. 5 448944 AB014605 Hs. 22599 atrophin-I interacting protein 1 ; ac6vi 5. 5 418630 A1351311 Hs. 251946 poly (A)-binding protein, cytoplasmic 1-1 5. 5 415734 NM 014747 Hs. 78748 KIAA0237 gene product 5. 5 410099 AA081630 KIAA0036 gene product 5. 5 453128 AW026516 Hs. 31791 acylphosphatase 2, muscle type 5. 5 444670 H58373 Hs. 332938 hypothetical protein MGC5370 5. 5 420345 AW295230 Hs. 25231 ESTs 5. 5 420092 AA814043 Hs. 88045 ESTs 5. 5 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 5. 4 429876 AB028977 Hs. 225974 KIAA1054 protein 5. 4 41, 9863 AW952691 Hs. 93485 Homo sapiens mRNA ; cDNADKFZp761D191 (fr 5. 4 429149 AW193360 Hs. 197962 ESTs, Weakly similar to 138022 hyptheti 5. 4 415486 H12214 Hs. 13284 ESTs, Weakly similar to 2109260A B cell 5. 4 429643 AA455889 Hs. 167279 FYVE-finger. containing RabS effector pro 5. 4 446657 A1335191 Hs. 260702 ESTs. Weakly similar to 2109260A Beet) 5. 4 439662 H97552 Hs. 269060 ESTs 5. 4 444165 AL137443 Hs. 10441 hypothetical protein FLJ 11236 5. 4 439192 AW970536 Hs. 105413 ESTs 5. 3 448769 N66037 Hs. 38173 ESTs 5. 3 410555 U92649 Hs. 64311 a disintegrin and metalloproteinase doma 5. 3 424922 BE386547 Hs. 217112 hypothetical protein MGC10825 5. 3 423905 AW579960 Hs. 135150 lung type-I cell membrane-associated gly 5. 3 429433 AA452899 Hs. 213586 ESTs, Weakly similar to KIAAL 353 protein 5. 3 427359 AW020782 Hs. 79881 Homo sapiens cONA : FLJ23006 fis, clone L 5. 3 422544 AB018259 Hs. 118140 KlM0716geneproduct 5. 3 420547 AF155140 Hs. 98738 gonadotropin-regulateotesticularRNAhe 5. 3 424624 AB032947 Hs. 151301 Ca2zdependentac6vatorproteinforsecr 5. 2 441797 A1936933 Hs. 214635 ESTs 5. 2 428832 AA578229 Hs. 324239 ESTs, Moderately similar to ZN91HUMANZ 5. 2 418079 R40058 Hs. 6911 ESTs 5. 2 445740 T78281 Hs. 13226 Homosapiensclone25181mRNAsequence 5. 2 416426 AA180256 Hs. 210473 Homo sapiens CDNA FU 14872 fis, clone PL 5. 2 436109 AA922153 Hs. 132760 hypothetical protein MGC15729 5. 2 433647 AA603367 Hs. 222294 ESTs 5. 2 452786 R61362 Hs. 106642 ESTs, Weakly similar to T09052 hypotheti 5. 1

436443 AW138211 Hs. 128746 ESTs 5. 1 408243 Y00787 Hs. 624 interleukin 8 5. 1 404819 NM002688' : Homo sapiens peanut (Drosophi 5. 1 424914 AA348410 Hs. 119065 ESTs 5. 1 453331 Al240665 ESTs 5. 1 444656 A1277924 Hs. 145199 ESTs 5. 1 437387 A1198874 Hs. 28847 AD026 protein 5. 1 421027 AA761198 Hs. 55254 ESTs 5. 1 410631 AA086469 Hs. 47171 ESTs 5. 1 454293 H49739 Hs. 134013 ESTs, ModeratelysimilartoHK61_HUMANH 5. 1 416220 N49776 Hs. 170994 hypthetcat protein MGC10946 5. 1 419498 AL036591 Hs. 20887 hypothe6ca'protein FW10392 5. 1 421040 AA715026 Hs. 135280 ESTs 5. 1 415170 R44386 Hs. 164578 ESTs 5. 1 412590 AL134388 Hs. 135033 ESTs, Weakly similar to 138022 hypotheti 5. 1 448985 AA324885 Hs. 22777 carbonic anhydrase XI 5. 0 433929 A1375499 Hs. 27379 ESTs 5. 0 409638 AW450420 Hs. 21335 ESTs 5. 0 437916 BE566249 Hs. 20999 hypotheticalprotein FU23142 5. 0 400533 ENSP00000209376' : PRED65 protein (Fragmen 5. 0 430130 AL137311 Hs. 234074 HomosapiensmRNA ; cDNADKFZp761G02121 (5. 0 437372 AA323968 Hs. 283631 hypothetical protein DKFZp547G183 5. 0 414737 Al160386 Hs. 125087 ESTs 5. 0 422864 AA318323 Hs. 12827 gb : EST20390RetinallHomosapienscDNA 5. 0 428878 AA436884 Hs. 48926 ESTs 5, 0 428841 A1418430 Hs. 104935 ESTs 5, 0 428110 A1312485 Hs. 138294 ESTs, Moderately similar to Z195_HUMAN Z 5. 0 444170 AW613879 Hs. 102408 ESTs 4. 9 448765 R15337 Hs. 21958 Homo sapiens mRNA ; cDNA DKFZp547D086 (fr 4. 9 452106 A1141031 Hs. 21342 ESTs 4. 9 417404 NM007350 Hs. 82101 pleckstrinhomology-likedomån, family 4. 9 414300 Api304870 Hs. 188680 ESTs 4. 9 429399 AA452244 Hs. 16727 ESTs 4. 9 439726 AW449893 Hs. 293707 ESTs, Weakly similar to 138598 zinc fing 4. 9 428873 A1701609 Hs. 98908 ESTs 4. 9 451516 A1800515 Hs. 12024 ESTs 4. 9 407792 A1077715 Hs. 39384 putative secreted ligand homologous to f 4. 9 416836 D54745 Hs. 80247 cholecystokinin 4. 9 447247 AW369351 Hs. 287955 Homo sapiens cDNA FLJ13090 fis, clone NT 4. 9 436805 AA731533 Hs. 270751 ESTs 4. 9 423175 W27595 Hs. 347310 hypothetical protein FU14627 4. 9 415402 AA164687 Hs. 177576 mannosyl (alpha-1, 3-)-glycoprotein beta-4. 9 422263 AA307639 Hs. 129908 KIAA0591 protein 4. 8 443715 A1583187 Hs. 9700 cyclin E1 4. 8 413248 T64858 Hs. 21433 hypothetical protein DKFZp547J036 4. 8 434811 AW971205 Hs. 114280 ESTs 4. 8 441287 AW293132 Hs. 131373 ESTs 4. 8 428862 Nom000346 Hs. 2316 SRY (sex determining region Y)-box 9 (ca 4. 8 413834 BE296896 Hs. 224179 ESTs, Weakly similar to 138022 hypotheti 4. 8 443740 R56434 Hs. 21062 ESTs 4. 8 416871 H98716 gb : yx13dO8. s1 Soaes melanocyte 2NbHM Ho 4. 8 441916 AA993571 Hs. 129075 ESTs 4. 8 413530 AA130158 Hs. 19977 ESTs. Moderately similar to ALUE-HUMAN A 4. 8 424240 AB023185 Hs. 143535 calciuMcalmodulin-dependent protein kin 4. 8 414998 NM 002543 Hs. 77729 oxidised low density lipoprotein (lectin 4. 8 448425 A1500359 Hs. 346112 ESTs 4. 8 423600 AI633559 Hs. 310359 ESTs 4. 8 424687 J05070 Hs. 151738 matrix metalloproteinae 9 (gela6nae B 4. 8 423869 BE409301 Hs. 134012 C1q-relatedfactor 4. 8 425402 AI215881 Hs. 24970 ESTs, Weakly similar to B34323 GTP-bindi 4. 7 422809 AK001379 Hs. 121028 hypothetical protein FLJ 10549 4. 7 407808 AA663559 Hs. 279789 histone deacetylase 3 4. 7 428748 AW593206 Hs. 98785 Ksp37 protein 4. 7 434859 BE255080 Hs. 299315 collapsin response mediator protein-5 ; C 4. 7 431820 AW410408 Hs. 271167 L-pipecolic acid oxidase 4. 7 409100 H98216 Hs. 42245 ESTs, Moderately similar to 138022 hypot 4. 7 420133 AA426117 Hs. 155543 ESTs 4 7 420297 A1628272 Hs. 88323 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 7 443462 A1064690 Hs. 171176 ESTs 47 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 4. 7 431454 AW975980 Hs. 292918 ESTs 4. 7 432682 A1376400 Hs. 159588 ESTs 4 7 434933 R91095 Hs. 4276 KIAA1701 protein 4. 7 421247 BE391727 Hs. 102910 general transcription factor IIH, polype 4. 7 435538 AB011540 Hs. 4930 low density lipoprotein receptor-related 4. 7 441703 AW390054 Hs. 192843 leucine zipper protein FKSG14 4. 7 418661 NM001949 Hs. 1189 E2Ftranscnptionfactor3 47 412266 N59006 Hs. 26133 ESTs 47 417675 AI808607 Hs. 3781 similar to munne leucine-nch repeat pr 4. 6 422564 A1148006 Hs. 222120 ESTs 4. 6 427250 R35941 Hs. 25418 ESTs 4. 6 427695 R88483 Hs. 172862 ESTs 4. 6 434269 AK001991 Hs. 3781 similar to mudne leucine-dch repeat pr 4. 6

407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, 4. 6 427687 AW003867 Hs. 1570 histamine receptor H1 4. 6 427194 AA399018 Hs. 250835 ESTs 4. 6 440286 U29589 Hs. 7138 cholinergic receptor, muscannic 3 4. 6 427099 AB032953 Hs. 173560 odd Oz/ten-m homolog 2 (Drosophila, mous 4. 6 458760 A1498631 Hs. 111334 festin. light polypeptide 4. 6 433675 AW977653 Hs. 75319 nbonucleo6de reductae M2 polypeptide 4. 6 429170 NM 001394 Hs. 2359 dual specificity phosphatase 4 4. 6 427712 A1368024 Hs. 283696 ESTs 4. 6 437834 AA769294 Hs. 283854 gb : nz36g03. s1 NCI_CGAP_GCB1 Homo sapiens 4. 6 408947 AL080093 Hs. 49117 Homo sapiens mRNA ; cDNA DKFZp564N1662 (f 4. 6 424458 M29273 Hs. 1780 myelin associated glycoprotein 4. 6 450568 AL050078 Hs. 25159 Homo sapiens cDNA FW10784 hs, clone NT 4. 6 424635 AA420687 Hs. 115455 Homo sapiens CDNA FU 14259 fis, clone PL 4. 6 440491 R35252 Hs. 130558 ESTs, Weakly similar to 2109260A B cell 4. 6 428409 AW117207 Hs. 98523 ESTs 4. 5 423476 AL035633 Human DNA sequence from clone RP5-1046G1 4. 5 421977 W94197 Hs. 110165 fibosomal protein L26 homolog 4. 5 440105 AA694010 Hs. 6932 Homo sapiens clone 23809 mRNA sequence 4. 5 422411 AW749443 Hs. 22511 ESTs 4. 5 443361 Ai792623 Hs. 133273 ESTs 4. 5 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 4. 5 408432 AW195262 gb : xn67bOix1 NCI_CGAP_CML1 Homosapiens 4. 5 444127 N63620 Hs. 13281 ESTs 4. 5 417435 NM_005181 Hs. 82129 carbonic anhydrase III, muscle specific 4. 5 422661 NM_014700 Hs. 119004 KIAA0665geneproduct 4. 5 440684 A1253123 Hs. 127356 ESTs. Highly similar to S21424 nestin [H 4. 5 407385 AA610150 Hs. 272072 ESTs, Weakly similar to 138022 hyphe6 4. 5 425256 BE297611 Hs. 155392 collapsin response mediator protein 1 4. 5 441364 AW450466 Hs. 126830 ESTs, WeaklysimilartoYD38_YEASTHYPOT 4. 5 430471 AF064845 Hs. 241523 hypotheticalprotein FLJ10142 4. 5 412043 BE156622 Hs. 333371 Homo sapiens clone TA40 untranslated mRN 4. 5 426503 AA380153 gb : EST93093 Skin tumor) Homo sapiens cD 4. 5 418771 AA807881 Hs. 25329 ESTs 4. 4 414706 AW340125 Hs. 76989 KIAA0097 gene product 4. 4 424800 AL035588 Hs. 153203 MyoD family inhibitor 4. 4 441217 A1922183 Hs. 213246 ESTs 4. 4 422421 AA325138 Hs. 235873 hypothetical protein FLJ22672 4. 4 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteopontin, 4. 4 444153 AK001610 Hs. 10414 hypothetical protein FLJ10748 4. 4 435542 AA687376 ESTs 4. 4 443912 R37257 Hs. 184780 ESTs 4. 4 414922 D00723 Hs. 77631 glycine cleavage system protein H (amino 4. 4 432527 AW975028 Hs. 102754 ESTs 4. 4 410082 AA081594 Hs. 158311 Musashi (Drosophila) homolog 1 4. 4 446936 H10207 Hs. 47314 ESTs 4. 4 425212 AW962253 Hs. 171618 ESTs 4. 4 426925 NM 001196 Hs. 315689 Homo sapiens cDNA : FLJ22373 fis, clone H 4. 4 427221 L15409 Hs. 174007 von Hippel-Lindau syndrome 4. 4 439274 AF086092 Hs. 48372 ESTs 4. 4 412799 A1267606 gb : aq91h03. x1 Stanley Frontal SB pool 1 4. 4 430676 AF084866 gb : Homo sapiens envelope protein RIC-3 (4. 4 405348 C7001664 : gil12698061ldbjlBAB21849. 1l (AB 4. 4 419412 AW161058 Hs. 90297 synuclein, beta 4. 3 447397 BE247676 Hs. 18442 E-1 enzyme 4. 3 409125 R17268 Hs. 343567 axonaltransprtofsynapticvesicles 4. 3 433323 AA805132 Hs. 159142 ESTs 4. 3 450530 Nom-006668 Hs. 25121 cytochrome P450, subfamily 46 (cholester 4. 3 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 4. 3 408622 AA056060 Hs. 202577 Homo sapiens cDNA FW12166 hs, clone MA 4. 3 433610 AA806822 Hs. 112547 ESTs 4. 3 429281 AA830856 Hs. 29808 HomosapienscDNA : FLJ21122 fis, clone C 4. 3 451320 AW118072 diacylglycerol kinase, zeta (104kD) 4. 3 430979 A1479755 Hs. 129010 ESTs 4. 3 452092 BE245374 Hs. 27842 hypothetical protein FLJ 11210 4. 3 438456 AA913381 Hs. 20594 ESTs 4. 3 433236 NM004296 Hs. 3221 regulator of G-protein signalling 6 4. 3 445133 AW157646 Hs. 198689 ESTs 4. 3 412125 Y17114 Hs. 73393 eyes absent (Drosophila) homolog 4 4. 2 432882 NM_013257 Hs. 279696 serum/glucocorticoid regulated kinase-ii 4. 2 407846 AA426202 Hs. 40403 Cbp/p300-interacGng transacGvator, wit 4. 2 417918 AA209205 Hs. 163754 hypthe6ca'protein FW12606 4. 2 424489 T48851 Hs. 274470 D-sigle precursor, 4. 2 453682 T79703 gb : yd71eO8. r1 Scares fetaiiiverspteen 4. 2 445568 H00918 Hs. 268744 KIAA1796 protein 4. 2 448526 AB028946 Hs. 21361 KIAA1023 protein 4. 2 426457 AW894667 Hs. 169965 chimerin (chimaerin) 1 4. 2 415796 R87548 Hs. 78854 ATPase, Na ? transporting, beta 2 polypep 4. 2 438875 AA827640 Hs. 189059 ESTs 4. 2 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 4. 2 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon- 4. 2 445921 AW015211 Hs. 146181 ESTs 4. 2 412190 R16180 Hs. 274461 ESTs 4. 2

445666 R59960 Hs. 282386 ESTs 4. 2 439538 AA837323 Hs. 56407 ESTs 4. 2 437814 Al088192 Hs. 135474 ESTs, Weakly similar to DDX9_HUMAN ATP-D 4. 2 410264 AK001853 Hs. 61508 HomosapienscDNAFLJ10991hs, clonePL 4. 2 409091 AW970386 Hs. 269423 ESTs 4. 2 459527 AW977556 Hs. 291735 ESTs, Weakly similar to 178885 serineRh 4. 2 426271 AF026547 Hs. 169047 chondroiGn sulfate proteoglycan 3 (neur 4. 2 432731 R31178 Hs. 287820 hbronectin 1 4. 2 423135 N67655 Hs. 26411 ESTs 4. 2 446131 NM000929 Hs. 290 phospholipase A2, group V 4. 2 424736 AF230877 Hs. 152701 microtubule-interacting protein that ass 4. 2 408298 Api745325 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 4. 2 452234 AW084176 Hs. 223296 ESTs. Weakly similar to 138022 hypotheb 4. 2 451468 AW503398 Hs. 293663 ESTs, Moderately similar to 138022 hypot 4. 2 429421 AL031658 Human DNA sequence from clone RP1-310013 4. 2 422374 AW732869 Hs. 1519 protein kinase, cAMP-dependent. egulato 4. 1 402145 Target Exon 4. 1 440483 A1200836 Hs. 150386 ESTs 4. 1 425018 BE245277 Hs. 154196 E4F transcription factor 1 41 448048 BE281291 Hs. 170408 ESTs, Moderately similar to A47582 Bcel 4. 1 445868 BE169357 Hs. 207428 ESTs 4. 1 431725 X65724 Hs. 2839 Nonie disease (pseudoglioma) 4. 1 435575 AF213457 Hs. 44234 triggering receptor expressed on myeloid 4. 1 424726 AK001007 Hs. 138760 Homo sapiens c DNA FU 10145 fis, clone H E 4. 1 450325 A1935962 Hs. 26289 ESTs 4. 1 450639 Al703186 Hs. 277174 ESTs 4. 1 445102 AW204610 Hs. 22270 ESTs 4. 1 416547 H62914 Hs. 268946 ESTs, Weakly similar to PC4259 femün 4. 1 430387 AW372884 Hs. 240770 nuclear cap binding protein subunit 2, 2 4. 1 408296 AL117452 Hs. 44155 DKFZP586G1517 protein 4. 1 439519 AA837118 Hs. 118366 ESTs 4. 1 442326 H92962 Hs. 124813 hypothetical protein MGC14817 4. 1 404150 Target Exon 4. 1 420805 L10333 Hs. 99947 reticulon 1 41 429125 AA446854 Hs. 271004 ESTs, Weakly similar to 138022 hyptheb 4. 1 427302 AA400540 Hs. 135282 Homo sapiens cDNA FLJ11554 fis, clone HE 4. 1 444534 AW271626 Hs. 42294 ESTs 4. 1 437414 AW894071 Hs. 48448 hypothetical protein DKFZp547C176 4. 1 418512 AW498974 diacylglycerol kinase, zeta (104kD) 4. 1 414217 A1309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 4. 1 449328 A1962493 Hs. 345303 ESTs 4. 1 432683 AW995441 Hs. 10475 ESTs 4. 1 435312 AJ243396 Hs. 4865 voltage-gated sodium channel beta-3 subu 4. 1 429163 AA884766 gb : am20a10. si Soares_NFL_T_GBC_S1 Homos 4. 1 453096 AW294631 Hs. 11325 ESTs 4. 1 414683 S78296 Hs. 76888 hypothetical protein MGC12702 4. 0 433523 H29882 ESTs 4. 0 422170 A1791949 Hs. 112432 anti-Mullerian hormone 4. 0 424120 T80579 Hs. 290270 ESTs 4. 0 448548 R13209 Hs. 21413 solutecarrierfamily12, (ptasiumchl 4. 0 433009 AA761668 gb : nz24cO8. s1 NCI CGAP GCB1 Homosapiens 4. 0 434834 AF156774 Hs. 324020 1-acylglycerol-3-phosphate aacyltransfe 4. 0 439099 AB037800 Hs. 6462 protein kinase C and casein kinase subst 4. 0 444001 A1095087 Hs. 152299 ESTs, Moderately similar to S65657 alpha 4. 0 413554 AA319146 Hs. 75426 secretogranin 11 (chromogranin C) 4. 0 423279 AW959861 Hs. 290943 ESTs 4. 0 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 4. 0 450581 AF081513 Hs. 25195 TGF-beta4 4. 0 435854 AJ278120 Hs. 4996 putative ankyhn-repeat containing prote 4. 0 433615 AA732982 Hs. 269607 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 0 424001 W67883 Hs. 137476 paternally expressed 10 4. 0 432058 AW665996 Hs. 130729 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 0 423713 AW754182 gb : RC2-CT0321-131199-011-cO1 CT0321 Homo 4. 0 419629 AB020695 Hs. 91662 KIAA0888 protein 4. 0 439108 AW163034 Hs. 6467 synaptogyrin 3 4. 0 440866 A1703103 Hs. 271360 hypothetical protein MGC16275 4. 0 422887 Al751848 Hs. 49215 ESTs 4. 0 405331 NM 02456QHomo sapiens hypothe6cal prot 4. 0 457005 AJ007421 Hs. 172597 sal (Drosophila)-like 3 4. 0 437948 AA772920 Hs. 303527 ESTs 4. 0 440471 AA886146 Hs. 307944 ESTs 4. 0 432149 AW614326 Hs. 133483 ESTs, Weakly similar to T34549 probable 4. 0 449655 A1021987 Hs. 59970 ESTs 4. 0 448299 AA497044 Hs. 20887 hypothe6cal protein FU10392 4. 0 435743 T66861, Hs. 12962 ESTs 4. 0 412659 AW753865 Hs. 74376 olfactomedin related ER localized protei 4. 0 430694 AA810624 Hs. 30936 ESTs, WeaklysimilartoH2BH_HUMANHIST0 3. 9 437807 A1017875 Hs. 136829 ESTs 3. 9 440085 BE270761 Hs. 23158 ESTs 3. 9 449722 BE280074 Hs. 23960 cyclin B1 3. 9 445523 Z30118 Hs. 293788 ESTs, Moderately similar to unnamed prot 3. 9 420948 AB016898 Hs. 100469 myeloidtiymphadormixed-lineageleukem 3. 9 407198 H91679 gb : yvO4aO7. s1 Soares fetal liver spleen 3. 9

447519 U46258 Hs. 339665 ESTs 3. 9 429038 AL023513 Hs. 194766 seizurerelatedgene6 (mouseplike 3. 9 414761 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homolaiq2 3. 9 404584 Target Exon 3. 9 449670 F07693 Hs. 85603 Homo sapiens mRNA ; cDNA DKFZp434K2172 (f 3. 9 414117 W88559 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 3. 9 433290 R20077 Hs. 302185 Homo sapiens clone 23618 MRNA sequence 3. 9 441707 R42637 Hs. 21963 hypotheticalprotein OKFZp76180514 3. 9 431789 H19500 Hs. 269222 mitogen-acbvated protein kinase 4 3. 9 434149 Z43829 Hs. 244624 hypothetical protein MGC5469 3. 9 446896 T15767 Hs. 22452 HomosapiensmRNAforKIM1737pnotein, 3. 9 411555 AF113537 Hs. 70669 HMP19protein 3. 9 426646 AA382787 Hs. 122713 ESTs 3. 9 450297 AW901347 Hs. 38592 hypothe6cal protein FU23342 3. 9 429228 A1553633 Hs. 326447 ESTs 3. 9 451433 AA021140 Hs. 269265 ESTs, Weakly similar to A46010 X-linked 3. 9 447937 AL109716 Hs. 20034 HomosapiensmRNAiulilengthinsertcDN 3. 9 436734 A1937612 Hs. 273758 hypotheticalprotein FU23112 3. 9 417576 AA339449 Hs. 82285 phosphonbosylglycinamide fortnyltransfer 3. 9 417632 R20855 Hs. 5422 glycoprotein M6B 3. 9 414245 BE148072 Hs. 75850 WAS protein family, member 1 3. 9 418203 X54942 Hs. 83758 CDC28 protein kinase 2 3. 9 453438 Ai469935 Hs. 22792 ESTs 3. 9 408449 NM 004408 Hs. 166161 dynamin 1 3. 8 411048 AK001742 Hs. 67991 hypothetical protein DKFZp434G0522 3. 8 405819 NM002578 : Homosapiensp21 (CDKN1A)-æti 3. 8 445255 NM_014841 Hs. 12477 synaptosomal-associated protein, 91 kDa 3. 8 432715 AA247152 Hs. 200483 ESTs, Weakly similar to KIAA1074 protein 3. 8 457292 A1921270 Hs. 281462 hypotheticaiprotein FU14251 3. 8 432593 AW301003 Hs. 51483 ESTs, Weakly similar to hypothetical pro 3. 8 413589 AW452631 Hs. 313803 ESTs, Highly similar to AF157831 noncl 3. 8 426847 S78723 Hs. 298623 5-hydroxytryptamine (serotonin) receptor 3. 8 410768 AF038185 Hs. 66187 Homo sapiens clone 23700 mRNA sequence 3. 8 417791 AW965339 Hs. 111471 ESTs 3. 8 454120 AB032990 Hs. 40719 hypothetical protein KIAA1164 3. 8 425154 NM001851 Hs. 154850 collagen, type IX, alpha 1 3. 8 449145 A1632122 Hs. 198408 ESTs 3. 8 446997 AA383439 Hs. 16758 Spir-1 protein 3. 8 407304 AA565832 Hs. 271649 gb : nj32b03. s1 NCI_CGAP_AAi Homo sapiens 3. 8 437269 AA334384 Hs. 149420 ESTs 3. 8 443539 A1076182 Hs. 134074 ESTs, Moderately similar to ALU6 HUMAN A 3. 8 426855 AL117427 Hs. 172778 Homo sapiens mRNA ; cDNA DKFZp566P013 (fr 3. 8 418821 AA436002 Hs. 183161 ESTs 3. 8 408875 NM015434 Hs. 48604 DKFZP434B168 protein 3. 8 422175 N79885 Hs. 6382 ESTs, HighlysimilartoT00391hypthe6 3. 8 432488 AA551010 Hs. 216640 ESTs 3. 8 450582 A1339732 G-rich RNA sequence binding factor 1 3. 8 426380 A1291267 Hs. 149990 ESTs 3. 8 451407 AA131376 Hs. 343809 fibroblast growth factor 128 3. 8 451778 A1826131 Hs. 62954 ESTs, Weakly similar to zinc finger prot 3. 8 425652 A8021742 Hs. 322431 neurogenic differentiation 2 3. 8 412820 BE001236 gb : CM3-BN0075-240200-101-d11 BN0075Homo 3. 8 412193 A1684467 Hs. 144057 ESTs 3. 8 431117 AF003522 Hs. 250500 delta (Drosophila ; Mike1 3. 8 433042 AW193534 Hs. 281895 Homo sapiens CDNA FU 11660 fis, clone HE 3. 8 437756 AA767537 Hs. 197096 ESTs 3. 8 451367 AA923729 Hs. 26322 cell cycle related kinase 3. 8 425390 A1092634 Hs. 156114 proteintyrosine phosphatase, non-recept 3. 8 445292 AV653264 Hs. 13982 Homo sapiens cDNA FW 14666 fis, clone NT 3. 8 425843 BE313280 Hs. 159627 death associated protein 3 3. 8 443301 Api733614 Hs. 220587 ESTs. Moderately similar to ALU5_HUMAN A 3. 7 440210 AW674562 Hs. 125296 ESTs 3. 7 430287 AW182459 Hs. 125759 ESTs, WeaklysimilartoLEU5_HUMANLEUKE 3. 7 437252 A1433833 Hs. 164159 ESTs, WeaklysimilartoALU1 HUMANALUS 3. 7 409327 L41162 Hs. 53563 coliagen, type IX, alpha 3 3. 7 429084 AJ001443 Hs. 195614 splicing factor 3b, subunit 3, 130kD 3. 7 457183 H91882 Hs. 118569 Dvl-bindingproteinlDAX (inhibitionof 3. 7 403696 C4001100': gil5852342lgblMD54015. 1l (AFO 3. 7 408670 AF160967 Hs. 46784 potassium large conductance calcium-acti 3. 7 416677 T83470 Hs. 334840 ESTs, Moderately similar to 178885 serin 3. 7 422253 W81526 Hs. 118329 ESTs, Moderately similar to GADHUMANGA 3. 7 450154 R15891 Hs. 281587 Human (clone CTG-A4) mRNA sequence 3. 7 408453 A1369838 Hs. 45127 chondroitin sulfate proteoglycan 5 (neur 3. 7 440553 AA889416 Hs. 344043 Homo sapiens cDNA FW 14459 hs, clone HE 3. 7 428536 Al143139 Hs. 2288 visinin-like 1 3. 7 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 3. 7 409172 Z99399 Hs. 122593 ESTs 3. 7 441627 AA947552 Hs. 58086 branched chain aminotransferae 1, cytos 3. 7 418216 AA662240 Hs. 283099 AF15qt4 protein 3. 7 408790 AW580227 Hs. 47860 neurotrophic Iyrosine kinase, receptor, 3. 7 437449 AL390153 Hs. 208339 Homosapiens mRNA ; cDNADKFZp762G113 (fr 3. 7 436035 AA703679 Hs. 106999 ESTs Weakiy simitar to SYT5HUMANSYNAP 3. 7 451697 AW449774 Hs. 296380 POM (POM121 rat homolog) and ZP3 fusion 3. 7

436961 AW375974 Hs. 156704 ESTs 3. 7 409953 AA332277 Hs. 57691 cadhenn 18, qpe 2 3. 7 435832 AA425688 Hs. 41641 Bruno (Drosophila)-like 4, RNA binding 3. 7 424343 AW956360 Hs. 4748 adenylate cyclase activating polypeptide 3. 6 437470 AL390147 Hs. 134742 hypotheticalprotein DKFZp547D065 3. 6 440168 AA868507 Hs. 126141 ESTs 3. 6 427624 AA406245 Hs. 24895 ESTs 3. 6 418293 A1224483 Hs. 16063 hypothetical protein FU21877 3. 6 445888 AF070564 Hs. 13415 Homosapiensclone24571mRNAsequence 3. 6 458912 A1911066 ESTs 3. 6 419390 Al701162 Hs. 90207 hypothetical protein MGC11138 3. 6 449256 AA059050 Hs. 59847 ESTs 3. 6 425010 T16837 Hs. 4241 ESTs 3. 6 412754 AW160375 Hs. 74565 amyloid beta (A4) precursor-tike protein 3. 6 400777 NM_007325' : Homo sapiens glutamate recept 3. 6 438831 BE263273 Hs. 6439 synapsin 11 3. 6 419235 AW470411 Hs. 288433 neurotrimin 3. 6 424947 R77952 ESTs, Weakly similar to atematively sp 3. 6 407624 AW157431 Hs. 248941 ESTs 3. 6 440351 AF030933 Hs. 7179 RAD1 (S. pombe) homolog 3. 6 440404 A1015881 Hs. 324527 mitochonddal ribosomal protein S5 3. 6 439267 AA287747 Hs. 173012 ESTs, Weakly similar to A46010 X-linked 3. 6 424340 AA339036 Hs. 7033 ESTs 3. 6 423178 A1033140 Hs. 124983 Homo sapiens mRNA ; cDNA DKFZp564C142 (fr 3. 6 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 3. 6 428483 A1908539 Hs. 184592 KIAA0344 gene product 3. 6 453875 AW001783 Hs. 232711 ESTs 3. 6 430183 BE010038 gb : PM3-BN0176-100400-001-g04BN0176Homo 3. 6 431552 A1815863 Hs. 259873 axonaltransportofsynap6cvesicles 3. 6 424278 AK000723 Hs. 144517 hypothetical protein FU20716 3. 6 434131 A1858275 Hs. 143659 ESTs 3. 6 435923 BE301930 Hs. 5010 Homo sapiens clone 24672 mRNA sequence 3. 6 415709 AA649850 Hs. 278558 ESTs 3. 6 437640 AA764893 Hs. 272155 ESTs, Weakly similar to 138022 hypothed 3. 6 419586 A1088485 Hs. 144759 ESTs, Weakly similar to 18022 hypotheti 3. 6 414040 N58513 Hs. 32171 ESTs 3. 6 427315 AA179949 Hs. 175563 HomosapiensmRNA ; cDNADKFZp564N0763 ( 3. 6 410711 AB002316 Hs. 65746 KIAA0318 protein 3. 6 445953 A1612775 Hs. 145710 ESTs 3. 6 444794 A1419991 Hs. 145225 ESTs 3. 6 411968 A1207410 Hs. 69280 Homo sapiens, clone IMAGE : 3636299, mRNA, 3. 6 428180 AI129767 Hs. 182874 guanine nucleotide binding protein (G pr 3. 6 415283 R40504 Hs. 21245 ESTs 3. 6 433160 AW207002 Hs. 134342 TASP for testis-specific adriamycin sens 3. 5 410386 W26187 Hs. 3327 Homo sapiens cDNA : FLJ22219 fis, clone H 3. 5 430818 A1311928 Hs. 348156 gb : qo89h04. x1 NCI_CGAP_Kid5 Homo sapiens 3. 5 433932 AW954599 Hs. 169330 neuronal protein 3. 5 420578 AA813546 Hs. 99034 GTP-binding protein Rho7 3. 5 456723 Z43902 Hs. 4748 adenylate cyclase activating polypeptide 3. 5 416340 N31772 Hs. 79226 fasciculation and elongation protein zet 3. 5 451455 A1937227 Hs. 8821 hepcidin antimicrobial peptide 3. 5 412719 AW016610 Hs. 816 ESTs 3. 5 435910 A1084152 Hs. 21782 ESTs, Weakly similar to ALU7_HUMAN ALU S 3. 5 439340 AB032436 Hs. 6535 brain-specific Na-dependent inorganic ph 3. 5 458072 A1890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 3. 5 439710 AF086543 gb : Homo sapiens full length insert cDNA 3. 5 453896 AW293483 Hs. 255205 KIAA1853 protein 3. 5 407253 AA411175 Hs. 141939 ESTs, Moderately similar to S65657 alpha 3. 5 449969 AW295142 Hs. 180187 Homo sapiens cDNA FW 14337 hs, clone PL 3. 5 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 3. 5 424332 AA338919 Hs. 101615 ESTs 3. 5 456497 AW967956 Hs. 123648 ESTs, WeaklysimilartoAF1084601 ubinu 3. 5 442264 Api278777 Hs. 263455 ESTs, Weakly similar to ALU 1_HUMAN ALU S 3. 5 404295 Target Exon 3. 5 427209 H06509 Hs. 92423 KlM1566protein 3. 5 439627 BE621702 Hs. 29076 hypothetical protein FU21841 3. 5 427513 A1476318 Hs. 192480 ESTs 3. 5 458435 Api418718 Hs. 144121 ESTs, Weakly similar to T46916 hypotheti 3. 5 435545 AA687415 Hs. 28107 ESTs 3. 5 413199 M62843 Hs. 75236 ELAV (embryonic lethal, abnormal vision, 3. 5 441607 NM 005010 Hs. 7912 neuronal cell adhesion molecule 3. 5 452449 AW068658 Hs. 20943 ESTs 3. 5 443257 A1334040 Hs. 11614 HSPC065 protein 3. 5 423641 AL137256 Hs. 130489 ATPase, aminophospholipid transporter-li 3. 5 427581 NM014788 Hs. 179703 KIAA0129 gene product 3. 5 424090 X99699 Hs. 139262 XIAPassociatedfactor-1 3. 5 422906 U80773 Hs. 121580 Human EST clone 42944 mariner transposon 3. 5 429698 Api685086 Hs. 26339 ESTs, Weakly similar to S21348 probable 3. 5 439920 H05430 Hs. 288433 neurotrimin 3. 5 436899 AA764852 Hs. 291567 ESTs 3. 5 414178 AW957372 Hs. 46791 ESTs, Weakly similar to 138022 hypotheti 3. 5 418365 AW014345 Hs. 161690 ESTs 3. 4 414598 A1094221 Hs. 135150 lung type-I cell membrane-associated gly 3. 4

452571 W31518 Hs. 34665 ESTs 3. 4 443633 AL031290 Hs. 9654 similar to pregnancy-associated plasma p 3. 4 408955 BE315170 Hs. 8087 Target CAT 3. 4 443206 AB011420 Hs. 9075 senne/theonine kinae 17a (apptosis-i 3 4 419617 AL008583 Hs. 91622 neuronal pentraxin receptor 3. 4 454171 AW854832 gb : QV2-CT0261-201099-011-f05CT0261Homo 3. 4 426529 AF090100 Hs. 170241 HomosapienscbnelMAGE23915 3. 4 440652 A1216751 Hs. 143977 ESTs 3. 4 450813 A1739625 Hs. 203376 ESTs 3. 4 429323 NM 001649 Hs. 2391 apical protein, Xenopus laevis-like 3. 4 439774 AL360257 Hs. 213493 Homo sapiens mRNA full length insert cDN 3. 4 409892 AW956113 Hs. 7149 gb : EST368183 MAGE resequences, MAGD Homo 3. 4 439963 AW247529 Hs. 6793 platelet-activabng factor acetylhydrola 3. 4 416658 U03272 Hs. 79432 fibrillen 2 (congenital contractural ara 3. 4 453740 AL120295 Hs. 311809 ESTs, Moderately similar to PC4259 feni 3. 4 435256 AF193766 Hs. 13872 cytokine-like protein C17 3. 4 453305 R39224 Hs. 267997 EHM2 gene 3. 4 425287 R88249 Hs. 155524 peanut (Drosophila)-like 2 3. 4 417663 R07483 Hs. 180461 ESTs 3. 4 448533 AL119710 Hs. 21365 nucleosomeassemblyprotein1-like3 3. 4 441834 AL138034 Hs. 7979 KIAA0736 gene product 3. 4 457876 Al821940 ESTs, ivioderatelysimilartoALU8_HUMANA 3. 4 407842 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 3. 4 422676 D28481 Hs. 1570 histamine receptor H 1 3. 4 408926 AF217525 Hs. 49002 Down syndrome cell adhesion molecule 3. 4 430762 A1343652 Hs. 105667 ESTs 3. 4 430890 X54232 Hs. 2699 glypican 1 3, 4 445078 A1869975 Hs. 4775 junctophilin 3 3. 4 423257 AW161039 Hs. 125878 synapsin 111 3. 4 417402 BE503227 Hs. 134759 ESTs 3. 4 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 3. 4 404541 NM030795 : Homo sapiens stathmin-like 4 (3. 4 436291 BE568452 Hs. 344037 protein regulator of cytokinesis 1 3. 4 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2oxoglutarate di 3. 4 432140 AK000404 Hs. 272688 hypothetical protein FLJ20397 3. 4 451061 AW291487 Hs. 213659 ESTs, Weakly similar to KIAAL 357 protein 3. 4 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 3. 4 420692 AW976345 gb : EST388454 MAGE resequences, MAGN Homo 3. 4 410507 AA355288 Hs. 76064 transitional epithelia response protein 3. 4 412436 AA665089 gb : nu76dO1. s1 NCl_CGAP_Av1 Homosapiens 3. 4 448112 AW245919 Hs. 34969 hypothetical protein DKFZp566N034 3. 4 429269 AA449013 Hs. 99203 ESTs 3. 4 408037 AW271720 Hs. 42233 hypothetical protein FLJ10300 3. 3 418858 AW961605 Hs. 21145 hypothetical protein RG083M05. 2 3. 3 420050 AL118615 Hs. 94653 neurochondrin 3. 3 436277 R88520 Hs. 120917 ESTs 3. 3 430412 AW341754 Hs. 189305 ESTs 3. 3 408554 AA836381 Hs. 315111 nuclearreceptorco-epressorlHDAC3comp 3. 3 432663 A1984317 Hs. 122589 ESTs 3. 3 449919 A1674685 Hs. 200141 ESTs 3. 3 438509 R45367 Hs. 101191 ESTs 3. 3 429037 X81895 Hs. 194765 H. sapiens GENX-5624 mRNA, 3'UTR 3. 3 445537 AJ245671 Hs. 12844 EGF-like-domain, multiple 6 3. 3 425537 AB007913 Hs. 158291 KIAA0444 protein 3. 3 408369 R38438 Hs. 182575 solute carder family 15 (H ? ? ? transport 3. 3 449686 AW072813 Hs. 270868 ESTs, ModeratelysimilartoALU4 HUMANA 3. 3 417333 AL157545 Hs. 173179 bromodomain and PHD fioger containing, 3 3. 3 410592 R94088 Hs. 43569 ESTs 3. 3 439444 Api277652 Hs. 54578 ESTs. Weakly similar to 138022 hyphe6 3. 3 435375 AI733610 Hs. 187832 ESTs 3. 3 409746 NM 004794 Hs. 56294 RAB33A, member RAS oncogene family 3. 3 425588 F07396 Hs. 46627 ESTs 3. 3 412155 R38167 Hs. 12449 HomosapenstransmembraneproteinHTMP1 3. 3 425242 D13635 Hs. 155287 KIAA0010 gene product 3. 3 417280 AW173116 Hs. 250103 ESTs 3. 3 423748 A1149048 Hs. 30211 hypothetical protein FLJ22313 3. 3 452856 AF034799 Hs. 30881 protein tyrosine phosphatase, receptor t 3. 3 419103 Z40229 Hs. 96423 hypothetical protein FU23033 3. 3 435718 R06569 Hs. 269534 ESTs 3. 3 449249 T52285 Hs. 193115 HomosapiensmRNAforKIM1764protein, 3. 3 423770 AW976766 Hs. 132776 Homo sapiens CDNA FU 10077 fis, clone HE 3. 3 409557 BE182896 Hs. 211193 ESTs 3. 3 439285 AL133916 hypothetical protein FU20093 3. 3 421183 AL135740 Hs. 102447 TSC-22-like 3. 3 433894 A1907682 Hs. 243293 ESTs 3. 3 445225 At216555 Hs. 202398 ESTs 3. 3 411379 A1816344 Hs. 12554 ESTs, Weakly similar to NPL4_HUMAN NUCLE 3. 3 436207 AA334774 Hs. 12845 hypothetical protein MGC13159 3. 3 436870 AW204219 Hs. 155560 calnexin 3. 3 441791 AW372449 Hs. 61271 hypothetical protein FLJ21159 3. 3 408547 AA574291 Hs. 57837 ESTs 3 3 420982 AW576160 Hs. 100729 KIAA0692 protein 3. 3 451625 R56793 Hs. 106576 alanine-glyoxYlate aminotransierae 2-li 3. 3

418932 L34059 Hs. 89484 cariherin 4, type 1, R-cadherin (retina)) 3. 3 453496 AA442103 Hs. 33084 solute carrier family 2 (facilitated glu 3. 3 423169 BE047009 Hs. 21837 ESTs, Weakly similar to KIAA0927 protein 3. 3 418049 AA211467 Hs. 190488 Homo sapiens, Similar to nuclear localiz 3. 3 441243 A1767056 Hs. 193002 ESTs 3. 3 444427 H25094 Hs. 293663 ESTs, Moderately similar to 138022 hypot 3. 3 449115 AW959952 Hs. 37528 ESTs, Weakly similar to AF090944 1 PR006 3. 3 446416 AV658299 Hs. 163959 ESTs 3. 3 437762 T78028 Hs. 154679 synaptotagmin 1 3. 3 450336 AA046814 Hs. 288928 Homo sapiens cDNA : FW23296 fis, clone H 3. 3 433842 A1652156 Hs. 26346 ESTs 3. 3 444124 R43097 Hs. 6818 ESTs 3. 3 423858 AL137326 Hs. 133483 Homo sapiens mRNA ; cDNA DKFZp434B0650 (f 3. 3 454792 AW820794 Hs. 252406 hypotheticalproteinFW12296similarto 3. 3 412775 AA709046 Hs. 27552 Homo sapiens mRNA ; cDNA DKFZp586N2424 (f 3. 3 429609 AF002246 Hs. 210863 cell adhesion molecule with homology to 3. 2 413951 AW051200 Hs. 75640 natnureticpeptide precursor A 3. 2 433325 AW206986 Hs. 143905 ESTs 3. 2 449092 U91641 Hs. 22985 alpha2, 8-sialyltransferase 3. 2 422390 AW450893 Hs. 121830 ESTs, Weakly similar to T42682 hypühe6 3. 2 424899 AL119387 Hs. 119062 ESTs 3. 2 454253 AV660717 Hs. 47144 DKFZP586N0819 protein 3. 2 410126 BE169274 KIAA0036 gene product 3. 2 456508 AA502764 Hs. 123469 ESTs, Weakly similar to AF2088551 BM-01 3. 2 405303 Target Exon 3. 2 420871 AA702972 Hs. 65300 ESTs 3. 2 442432 BE093589 Hs. 38178 hypothetical protein FW23468 3. 2 425769 U72513 Hs. 159486 Human RPL13 2 pseudogene mRNA, complele 3. 2 442320 A1287817 Hs. 129636 ESTs 3. 2 407378 AA299264 Hs. 57776 ESTs, Moderately similar to 138022 hypot 3. 2 439764 T26535 Hs. 22744 hypothetical protein MGC13105 3. 2 410425 BE278367 Hs. 63510 KIAA0141 gene product 3. 2 422156 N34524 gb : yy56d10. s1 Soares_multiple_sclerosis 3. 2 451489 NM005503 Hs. 26468 amyloid beta (A4) precursor protein-bind 3. 2 457358 A1479755 Hs. 129010 ESTs 3. 2 407721 Y12735 Hs. 38018 dual-specificity tyrosine- (Y)-phosphoryl 3. 2 452372 A1885742 Hs. 228474 ESTs 3. 2 459660 M79082 ESTs 3. 2 437085 AA743935 Hs. 202329 ESTs 3. 2 419852 AW503756 Hs. 286184 hypothetical protein dJ551D2. 5 3. 2 440080 AW051597 Hs. 143707 ESTs 3. 2 449714 AB033015 Hs. 23941 KIAAL 189 protein 3. 2 450407 NM000810 Hs. 24969 gamma-aminobutyric acid (GABA) A recepto 3. 2 423165 A1937547 Hs. 124915 hypothetical protein MGC2601 3. 2 449961 AW265634 Hs. 133100 ESTs 3. 2 454036 AA374756 Hs. 93560 Homo sapiens mRNA for KIAA1771 protein, 3. 2 419865 NM_007020 Hs. 93502 Ut-snRNP binding protein homolog (70kD) 3. 2 423420 A1571364 Hs. 128382 Homo sapiens mRNA ; cDNA DKFZp76111224 (f 3. 2 420352 BE258835 gb : 601117374F1 NIH_MGC_16 Homo sapiens c 3. 2 424641 AB001106 Hs. 151413 glia maturabon factor, beta 3. 2 453544 AA831785 Hs. 171914 Homo sapiens cDNA FW14209 hs, clone NT 3. 2 447877 A1435184 Hs. 164252 ESTs 3. 2 419683 AA248897 Hs. 48784 ESTs 3. 2 451026 AA013218 Hs. 157492 cer-d4 (mouse) homolog 3. 2 422709 AA315331 Hs. 153485 ESTs 3. 2 432809 AA565509 Hs. 131703 ESTs 3. 2 446593 W79572 Hs. 13277 hypothetical protein FLJ22054 3. 2 457728 AW974811 gb : EST386916 MAGE esequences, MAGN Homo 3. 2 403790 NM_001334' : Homo sapiens cathepsin 0 (CTS 3. 2 445413 AA151342 Hs. 12677 CGI-147 protein 3. 2 438703 A1803373 Hs. 31599 ESTs 3. 1 434577 R37316 Hs. 179769 Homo sapiens cDNA : FLJ22487 fis, clone H 3. 1 422772 AL119585 Hs. 120228 KIAA0749 protein 3. 1 433434 AA588429 gb : no22bO3. s1 NCl_CGAP_Pr22 Hamosapiens 3. 1 427961 AW293165 Hs. 143134 ESTs 3. 1 414430 A1346201 Hs. 76118 ubiquitin carboxyl-terminal esterase L1 3. 1 420552 AK000492 Hs. 98806 hypothe6calprotein 3. 1 456209 W60633 Hs. 297792 ESTs 3. 1 418819 AA228776 Hs. 191721 ESTs 3. 1 438944 AA302517 Hs. 92732 KIAA1444 protein 3. 1 439086 AF085947 gb : HomosapiensfulilengthinsertcDNA 3. 1 451734 NM006176 Hs. 26944 neurogranin (protein kinase C substrate, 3. 1 415257 F03016 Hs. 27513 ESTs 3. 1 442789 AW904361 Hs. 131191 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 1 432675 A1791855 Hs. 105884 ESTs 3. 1 426600 NM 003378 Hs. 171014 VGF nerve growth factor inducible 3. 1 435092 AL137310 Hs. 4749 Homo sapiens mRNA ; cDNA DKFZp761E13121 (3. 1 439039 A1656707 Hs. 48713 ESTs 3. 1 450358 AB010098 Hs. 24907 coronin, ac6n-binding protein, 2B 3. 1 400850 Target Exon 31 417636 R08916 Hs. 191212 ESTs 31 425790 AW136286 Hs. 288446 ESTs 3. 1 415314 N88802 Hs. 5422 glycoprotein M6B 31

436456 AW292677 Hs. 248122 G protein-coupled receptor 24 3. 1 408601 U47928 Hs. 86122 protein A 3. 1 420886 AA805453 ESTs, Weakly similar to T29012 hypotheti 3. 1 437162 AW005505 Hs. 5464 6hyroidhomlonereceptorcoæ6va6ngpr 3. 1 445704 A1493742 Hs. 167700 ESTs, Moderately similar to 138022 hypot 3. 1 440700 AW952281 Hs. 296184 guanine nucleo6de binding protein (G pr 3. 1 414747 U30872 Hs. 77204 centromere protein F (350/400kD, mitosin 3. 1 431553 X78075 Hs. 2799 cartlage linking protein 1 3. 1 405605 C2001342 : gil127814lsplP26434lNAH4_RAT SO 3. 1 431467 N71831 Hs. 256398 Homo sapiens mRNA ; cDNADKFZp434E0528 (f 3. 1 457561 AA331517 Hs. 286055 chimerin (chimaerin) 2 3. 1 412507 L36645 Hs. 73964 EphA4 3. 1 413448 AL134467 Hs. 25307 Homo sapiens clone 24812 mRNA sequence 3. 1 444168 AW379879 gb : RC1-HT0256-081199-011-f01 HT0256 Homo 3. 1 400090 Eos Control 3. 1 433642 BE466341 Hs. 189746 ESTs, Weaklysimilartol38022hypthe6 3. 1 422938 NM_001809 Hs. 1594 ntrom reproteinA (17kD) 3. 1 426318 AA375125 Hs. 147112 HomosapienscDNA : FLJ22322 fis, clone H 3. 1 428896 AW291932 Hs. 98936 ESTs 3. 1 449277 AA001064 Hs. 43670 ESTs 3. 1 426509 M31166 Hs. 2050 pentaxin-related gene, rapidly induced b 3. 1 412216 AW901517 gb : RC5-NN1013-310300-021-C03 NN1013 Homo 3. 1 428845 AL157579 Hs. 153610 KIAA0751 gene product 3. 1 431512 BE270734 Hs. 2795 lactate dehydrogenase A 3. 1 418113 Api272141 Hs. 83484 SRY (sex determining region Y)-box 4 3. 0 450661 AW952160 Hs. 83849 ESTs 3. 0 448448 NM014954 Hs. 21239 KIAA0985 protein 3. 0 422631 BE218919 Hs. t 18793 hypothetical protein FLJ10688 3. 0 419687 A1638859 Hs. 227699 ESTs, Weakly similar to T2D3_HUMAN TRANS 3. 0 450963 AI864668 Hs. 48832 ESTs 3. 0 435060 A1422719 Hs. 120873 ESTs, Weakly similar to fork head like p 3. 0 440274 R24595 Hs. 7122 scrapie responsive protein 1 3. 0 437438 AL359620 Hs. 14217 hypothetical protein DKFZp762P2111 3. 0 435401 R44477 Hs. 10056 hypothetical protein FLJ14621 3. 0 416737 AF154335 Hs. 79691 UM domain protein 3. 0 445314 A1689948 Hs. 65489 Homo sapiens cDNA : FLJ21517 fis, clone C 3. 0 425870 R13406 Hs. 56782 ESTs 3. 0 425294 AF033827 Hs. 155553 HNK-1 sulfotransferae 3. 0 416404 AA180138 Hs. 107924 ESTs 3. 0 413995 BE048146 Hs. 75671 syntaxin tA (brain) 3. 0 422798 R92347 Hs. 34574 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 0 426384 A1472078 Hs. 303662 hypthetical protein FW13189 (FW13189) 3. 0 430147 R60704 Hs. 234434 hairy/enhancer-of-split related with YRP 3. 0 425264 AA353953 Hs. 20369 ESTs, Weakly similar to gonadotropin ind 3. 0 406917 X65964 gb : H. sapiens nes6n gene. 3, 0 425262 D87119 Hs. 155418 GS3955 protein 3. 0 401558 ENSPOO000220478* : SECRETOGRANIN 111. 3. 0 439345 AW444759 Hs. 146171 ESTs 3. 0 414865 AA157155 Hs. 274414 hypothetical protein FU14457 3. 0 453976 BE463830 Hs. 163714 ESTs 3. 0 404283 ENSP00000244751' : Copine-like protein KIA 3. 0 432890 NM014442 Hs. 279751 sialic acid binding Ig-like lec6n 8 3. 0 451491 A1972094 Hs. 286221 Homo sapiens cDNA FLJ13741 fis, clone PL 3. 0 442573 H93366 Hs. 7567 branched chain aminotransferase 1, cytos 3. 0 428361 NM015905 Hs. 183858 transcnptionaiintermetfiary factor 1 3. 0 443753 AW367578 Hs. 134749 ESTs 3. 0 417868 A1078534 Hs. 122592 ESTs 3. 0 443898 AW804296 Hs. 9950 Sec61 gamma 3. 0 438869 AF075009 gb : Homo sapiens full length insert cDNA 3. 0 453900 AW003582 Hs. 226414 ESTs, Weakly simitar to ALU8_HUMAN ALU S 3. 0 447714 AW296313 Hs. 255537 ESTs 3. 0 426581 AB040956 Hs. 135890 K1AA1523 protein 3. 0 421126 M74587 Hs. 102122 insulin-like growth factor binding prote 3. 0 410762 AF226053 Hs. 66170 HSKM-B protein 3. 0 431462 AW583672 Hs. 256311 granin-like neuroendocfine pepude precu 3. 0 452221 C21322 Hs. 288057 hypothetical protein FU22242 3. 0 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 3. 0 428600 AW863261 Hs. 242413 hypothetical protein DKFZp434K1421 3. 0 426501 AW043782 Hs. 293616 ESTs 3. 0 405558 Target Exon 3. 0 421483 Nu003388 Hs. 104717 hypothetical protein MGC11333 3. 0 448681 AL109781 Hs. 21754 Homo sapiens mRNA full length insert cDN 3. 0 452108 AW135982 Hs. 203013 hypothetical protein FU12748 3. 0 429569 AA454993 Hs. 138343 ESTs, Weakly similar to 178885 senne/th 3, 0 450728 AW162923 Hs. 25363 pesenilin 2 (Alzheimer diseae 4) 3, 0 429371 NM 001703 Hs. 200586 brain-specific angiogenesis inhibitor 2 3. 0 437435 AA249439 Hs. 27027 hypothetical protein DKFZp762Hi311 3. 0 432188 A1362952 Hs. 2928 solute carrier family 7 (ca6onic amino 3. 0 404632 NM022490 : Homo sapiens hypothetical prot 3. 0 452619 AW298597 Hs. 61884 Homo sapiens, clone IMAGE : 4298026, mRNA, 3. 0 421458 Nom-003654 Hs. 104576 carbohydrate (keratan sulfate Gal-6) sul 3. 0 419038 AW134924 Hs. 190325 ESTs 3. 0 453563 AW608906 Hs. 181163 hypothetical protein MGC5629 3. 0

405239 U89281 oxidative 3 alpha hydroxysteroid dehydro 3. 0 TABLE 17B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408432 10586671 AW195262R27868AW811262 410099 117647_1 AA081630 T08671 A1174254 D83874 AW959843 AA364503 AA693467 AW993370 BE327037 AA167714 N79906 AW901977 AW901980 W52882 T07735 AA484549 W60090 D52685 T23811 BE327043 AW901768 BE551237 AA917004 AA716027 AI439658 AA283724 AI805992 AI457096 AA084618 BE467736 A1092635 A1887863 AI697593 AA436618 AI167419 AI418634 T31586 AA436630 AA706191 Al041169 Al422304 T03534 AA211402 Al204899 Al366472 AW827081 AA788593 T32736 A ! 767935 AA167791 AA747914 AA663870 A ! 865504 410126 1177611 BE169274 AW893230 AA210998 H24222 AA081774 BE000935 BE000834 AA334880 412216 1283670_1 AW901517AW901523AW901521AW901547 412436 129439. 1 AA665089AA135130AA484059AA102419AW877765 412799 132817 1 A1267606 AA121045AA126521 412820 1330039_1 BE001236 BE001177 BE001180 BE001234 414372 143909 1 AA143654 AW753140 AA213770 AW970865 AA569075 AA492132 416871 1626761 1 H98716 N90792 N24283 418512 176394_1 AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074 AW890649 419544 185760 2 AI909154 AA526337 AA244193 AI909153 420352 192979 1 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280 420692 195649_1 AW976345 M279423 M761070 420886 197344 1 AA805453 AA281379 422156 212379_1 N34524M305071 AW954803 AA502335 Al433430 Al203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512 Api334966 W32951 H62656 H53902 R88904 AW835732 422949 223184 1 AA319435 N56456 AA319377 AW961532 T48452 AA894424 423476 22861 1 AL035633 F11794 F11783 H18042 T66089 H29379 R19493 AW134660 A1299437AL133995 AA057405 N78357 AA917450 A1002692 T09262 T65008 H29290 AI200874 AA894415 AI732887 AI791768 AI733447 AA988785 N62128 T09261 AW956936 423713 231290_t AW754182 AW754198 AA329983 424945 245223_1 A ! 221919Z19967AA348780AW964077AW166028 BE540193 N94800 M452368 N99604 A1341345 AW298800 M724961 M931158 A1741227 Al806$0 Al982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 Al492961 A1361526 F04002 AA452141 T23551 Al472655 Al193667 Al341984 N92658 T32870 R52664 N50428 AW089291 Al934175 Al423737 D60665 424947 245247_1 R77952 AA348809 AW959960 AW959962 Al565552 AW070702 AA973910 R85973 426413 266650 1 AA377823 AW954494 A1022688 426503 268283_t AA380153 AA380233 AW963529 426919 273507 1 AL041228 D82004 D61361 AI203314 AI990307 AW900295 A1018308 AW087473 AW183530 AA393346 H50055 AA935601 428342 290035_2 A1739168 AA426249 Al 199636 AW505198 AW977291 AA824583 AA8834 19 AA724079 AIOI 5524 A1377728 AW293682 A1928140 AA731438 A1092404 A1085630 AA731340 429007 298301_1 D80642 M443145 AL119015 AW904500 429163 3005431 AA884766 AW974271 AA592975 AA447312 429421 30431 1 AL031658 AI693758 AL040619 AW977914 M811957 A1352198AW104364 M648367 M897604 AW341668 Al201382 AL040620 430183 31412 2 BE010038 AA676833 AI311783 T86895 W68032 BE064393 BE064394 BEi 57228 BE183282 AI936370 AA552514 T67280 AA039909 430676 32168_1 AF084866AF084870 AF084864 AF084867 AF084869AF084865AF084868 AW818206 AW812038 BE144813 BE144812 AW812041 AW812040 AW812067 BE061583 BE061604 T05808 Al352469 M580921 BE141783 BE141782 BE061601 AW814393 AW885029 430968 3262691 AW972830AA527647AA489820AA570362 433009 357371 1 AA761668 AA573621 R92814 R09670 433434 366095_1 M588429 Al972567 AW504832 A1299694 433523 368873_1 H29882 AW665533AW149901 Al572917 M598500 A1686466AI336390 AW864390 AW864320 435542 407744_1 M637376 H74234 AW975503 438869 46651_1 AF075009 R63109 R63068 439086 46852_1 AF085947 H70981 H78989 439285 47065_1 AL133916 N79113AF086101 N76721 AW950828 AA364013 AW955684 A1346341 A1867454 N54784 A1655270 A1421279 AW01 4882 AAT75552 N62351 N59253 AA626243 AI341407 BE175639 AA456968 AI358918 AA457077 439518 47334_1 W76326AF086341 W72300 439566 47387_1 AF086337 W77884 W72711 439710 47550 1 AF086543 W96291 W96225 441102 509604_1 M973905A1299888M917019H63235T90771 444168 593829 1 AW379879 A1126285 H12014 446692 689623 1 Z44514 AI352097 A1803984 AW235923 AW196558 A1954637 A1336983 447197 711623_1 R36075 A1366546 R36167 449625 81131 NM014253AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760 N48674 A1375997 R45432 D59344 A1203107 F07491 R35360 R25094 A1913631 A1498402 T61382 Al016320 N45526 T61415 AA331486 450375 83327_1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532 AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 AI161014 AA099554 R69067 450582 83933_1 Al339732 M010300 AW515041 AA768334 N29860 AA425874 AA425118 AA865829 AW936878 451320 86576_1 AW118072 Al631982 T15734 M224195 Al701458 W20198 F26326 AA890570 N90552 AW071907 A1671352 A1375892 T03517 R88265 Al124088 AA224388 A1084316 AI354686 T33652 AI140719 AI720211 T03490 A1372637 Tl 5415 AW205836 AA6303B4 T03515 T33230 AA017131 AA443303 T33623 A1222556 T33511 T33785 A1419606 D55612 453331 96214_1 A1240665 T53681 N77468 H51833 AA147247 R75732 C18450 R73999 A1095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292 R31981 H12498 H02668 AA035018 R75957 A1803329 R27528 R36203 A1809932 Al808765 R78948 M411449 M976929 A1378760AI378620 T48870 R73906 R75632 H03612 AA909684 N50695 H02580 H 12839 N5878 1 M742532 Al 360919 H03502 BE208298 R68588 Api350463 R31935 AW069127 AA411621 R25671 R36105 H12451 H03869 H51263 AA035486 R25109 R25110M147933 453682 977454 1 T79703 T96307 AL079725 454171 1049240_1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 457728 393853_1 AW974811 M651634M650072 457876 42814 2 A1821940 N67106 AI744264 AA808846 AA643417 AA643416170715 458912 823104_1 Al911066 Al933734 A1680888 AJ003599 TABLE 17C : Pkey : Unique number corresponding to an Eos probeset

Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 400533 6981826 Minus 277132-277595 400777 8131663 Plus 70745-71121 400850 1927150 Minus 4506-4691 401558 7139678 Plus 10351104090 402145 8018280 Plus 113086-114800 402604 9909420 Plus 20393-20767 402855 9662953 Minus 59763-59909 403696 3135242 Minus 143467-143634 403790 8084957 Minus 87826-87947, 89835-90002 404150 7534008 Plus 165811-165943 404283 2276311 Minus 99460-99564 404295 9856663 Minus 75747-75947 404541 8318559 Plus 103456-103664 404584 9857511 Plus 138651-139153 404632 9796668 Plus 45096-45229 404819 4678240 Plus 1622316319, 16427-16513, 1673616859, 16941-17075, 17170-17287, 17389-17529, 18261-18357, 1844318578 405239 7249119 Plus 144345-144464. 144690-144836. 151750-151883. 152407-152484 405303 2078453 Minus 130607-130802 405331 3236226 Minus 32502-32690 405348 2914717 Minus 43310-43462 405558 1621110 Plus 4502-4644, 5983-6083 405605 5836195 Minus 117070-117270 405819 4007557 Plus 2830-2967 TABLE 18A : ABOUT 446 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL ADULT CNS Table 18A lists about 446 CNS-enriched genes significantly down-regulated in glioblastoma multiforma (GBM) compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to'average'GBM was greater than or equal to 2. The averaqe-nomma' CNS level was set to the 85"'percentile amongst various normal CNS tissues. The'average'GBM level was set to the 85°'percentile amongst vanous tumor samples. To enrich for CNS specific genes, the ratio of'average'CNS to'average'non-CNS normal adult tissues was calculated to be greater than or equal to 3. The'average'CNS level was set to the 85°'percentie amongst various CNS tissues. The'average'normal non-CNS adult tissue level was set to the 95"'percentile amongst various non-CNS normal tissues, In order to remove gene-specific background levels of non-specific hybridization, the 10t percen61e våue amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratios were evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of CNS to GLIOBLASTOMA MULTIFORMA R2 : Ratio of CNS to NON-CNS NORMAL ADULT TISSUES Pkey ExAccn UnigenelD Unigene Title R1 R2 425489 M58594 Hs. 1905 prolactin 38. 8 10. 5 410330 AW023630 Hs. 159425 ESTs 23. 4 23. 4 430538 AB032435 Hs. 242821 differenhation-associatedNa-dependent 22. 6 22. 6 417275 X63578 Hs. 295449 parvalbumin 22. 4 6. 0 453590 AF150278 Hs. 33578 KIAA0820 protein 22. 3 22. 3 428505 AL035461 Hs. 2281 chromogranin B (secretogranin 1) 21. 8 21. 8 453220 AB033089 Hs. 32452 Homo sapiens mRNA for KIAA1263 protein, 19. 9 19. 9 411498 NM 014210 Hs. 70499 ecotropic viral integration site 2A 19. 4 19. 4 408040 A1266496 Hs. 22905 ESTs, Weakly similar to RHG6_HUMAN RHO-G 19. 4 19. 4 435145 Api277259 Hs. 116631 ESTs 18. 5 3. 8 407039 X00368 gb : Human prolactin gene 5'region. 18. 1 18. 1 409263 AA069573 Hs. 50319 ESTs 16. 8 16. 8 449078 AK001256 Hs. 22975 KIAA1576 protein 16. 1 16. 1 426968 U07616 Hs. 173034 amphiphysin (Stiff-Mann syndrome with br 15. 3 15. 3 432298 AL118812 Hs. 274293 HomosapiensmRNA ; cDNADKFZp761G1111 (f 15. 1 15. 1 424645 NM 014682 Hs. 151449 KIAA0535 gene product 15. 1 15. 1 450590 A1701507 Hs. 273740 ESTs 14. 9 3. 8 417175 R44558 Hs. 94002 ESTs 14. 6 8. 9 423449 A1497900 Hs. 33067 ESTs 14. 5 14. 5 441869 NM 003947 Hs. 8004 huntingtin-associated protein interactin 14. 4 14. 9 405560 AW887701 hypothetical protein FLJ20628 14. 0 8. 0 440209 H05049 Hs. 247837 neuexin 3 13. 9 18. 7 439238 N47305 Hs. 302161 ESTs 13. 9 5. 3 452022 AW072330 Hs. 293875 ESTs 13. 8 13. 8 459080 AW192083 Hs. 290855 ESTs 13. 5 13. 5 425649 U30930 Hs. 158540 UDP glycosyltransferase 8 (UDPalactose 13. 4 38. 6 413324 V00571 Hs. 75294 corticotropinreteasing hormone 13. 2 13. 2 443992 AW022228 Hs. 322922 ESTs 13. 1 13. 1 410635 D58863 Hs. 334372 chononicsomatomammotropin hormone 1 (p 12. 9 6. 6 420156 AW449258 Hs. 6187 ESTs 12. 5 12. 5 416490 AF090116 Hs. 79348 regulator of G-protein signaling 7 12. 5 12. 5 450757 BE081050 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 12. 2 3. 2 410037 AB020725 Hs. 58009 KIAA0918 protein 12. 2 12. 2 433940 H05129 cyclic AMP-regulated phosphoprotein, 21 12. 0 12. 0 434367 AB020700 Hs. 3830 KIAA0893 protein 11. 6 5. 6 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 11. 5 11. 5

431988 AC002302 Hs. 77202 protein kinase C, beta 1 11. 2 10. 5 451783 R42554 Hs. 210862 T-box, brain, 1 11. 2 11. 2 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 10. 7 10. 7 452238 F01811 Hs. 345757 ESTs 10. 6 3. 8 417167 AW206437 Hs. 4290 ESTs 10. 4 10. 4 420033 D59502 Hs. 292590 ESTs 10. 4 10. 4 427224 AL135554 Hs. 101937 sine oculis homeobox (Drosophila) homolo 10. 4 3. 9 424153 AA451737 Hs. 141496 MAGE-like 2 10. 3 5. 1 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 10. 0 10. 0 400438 AF185611 Hs. 115352 Target 9. 9 5. 1 447750 A1422234 Hs. 143434 contactin 1 9. 8 9. 8 419347 C15944 Hs. 90005 superior ganglia, neural specifi 9. 8 22. 2 418207 C14685 Hs. 34772 ESTs 9. 8 9. 8 413409 Al638418 Hs. 1440 DEAD/H (Asp-Giu-Aa-AspvHis) box polypep 9. 4 9. 4 447746 AW015920 Hs. 161359 ESTs 9. 2 9. 9 406311 NM021979' : Homosapiensheatshock70kD 9. 1 11. 5 444330 Al597655 Hs. 49265 ESTs 9. 1 9. 1 426365 AA376667 Hs. 10283 RNA binding motif protein 8B 9. 0 4. 1 427322 AK002017 Hs. 176227 hypothetical protein FLJ11155 8. 9 8. 9 439450 R51613 Hs. 125304 ESTs 8. 7 8. 3 429096 AB011106 Hs. 196012 KIAA0534 protein 8. 6 8. 6 428652 M584272 Hs. 336224 transmembrane protein with EGF-like and 8. 6 8. 6 408814 N62499 Hs. 176227 hypotheocal protein FU 11155 8. 6 8. 6 410309 BE043077 Hs. 278153 ESTs 8. 5 8. 5 408950 AA707814 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 8. 5 8. 5 426814 AF036943 Hs. 172619 myelin transcription factor 1-like 8. 5 14. 2 416851 AW963951 Hs. 85618 ESTs 8. 5 8. 5 430004 U27768 Hs. 227571 regulator of G-protein signalling 4 8. 4 15. 7 412155 R38167 Hs. 12449 Homo sapiens transmembrane protein HTMP1 8. 4 27. 9 427061 AB032971 Hs. 173392 KIAA1145 protein 8. 4 8. 4 412049 N53437 Hs. 18268 adenylate kinase 5 8. 3 10. 7 452752 AW044058 Hs. 33578 KIAA0820 protein 8. 2 13. 4 414699 A1815523 Hs. 76930 synuclein, alpha (non A4 component of am 8. 2 4. 5 422756 AA441787 Hs. 119689 glycoprotein hormones, alpha polypeptide 8. 1 5. 8 435648 H24347 Hs. 27524 ESTs 8. 1 8. 1 429470 A1878901 Hs. 203862 guanine nucleotide binding protein (G pr 8. 0 8. 0 416133 NM 001683 Hs. 89512 ATPase, Ca transporting, piasma membrane 8. 0 8. 0 438208 AL041224 Hs. 65379 ESTs 7. 9 5. 8 436427 A1344378 Hs. 143399 ESTs 7. 8 7. 8 441005 Z41305 Hs. 303172 Homo sapiens mRNA ; cDNADKFZp547G133 (fr 7, 7 7. 7 442023 A1187878 Hs. 144549 ESTs 7. 7 5. 6 444458 BE041526 Hs. 31746 hypothetical protein DKFZp547F072 7. 7 7. 7 429033 Nom 007374 Hs. 194756 sineoculishomeobox (Drosophila) homolo 7. 6 5. 5 450642 R39773 Hs. 7130 copine fiv 7. 6 5. 6 446544 A1631932 Hs. 7047 ESTs, Weakly similar to Unknown (H. sapie 7. 5 12. 4 438283 A1458931 Hs. 37282 ESTs 7. 5 7. 5 437073 AI885608 Hs. 94122 ESTs 7. 5 7. 5 408577 H50572 Hs. 19515 ESTs, Highly similar to NRG3-HUMAN PRO-N 7. 4 7. 4 424264 D80400 Hs. 239388 Human DNA sequence from clone RP1-304B14 7. 3 7. 3 441264 AA927170 Hs. 23290 ESTs 7. 3 7. 3 450474 AW872844 Hs. 117494 ESTs 7. 2 7. 2 425352 Nom-000939 Hs. 1897 proopiomelanocortin (adrenocortcotropin 7. 2 6. 1 450715 A1266484 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 7. 2 7. 2 450181 H05254 Hs. 201198 ESTs 7. 2 7. 2 415076 NM 000857 Hs. 77890 guanylate cyclase 1, soluble, beta 3 7. 1 4. 8 419318 AW969742 Hs. 291005 ESTs 7. 1 3. 1 423003 AL120077 Hs. 122967 kelch (Drosophila)-like 2 (Mayven) 7. 0 7. 0 434460 AA478486 Hs. 3852 KIAA0368 protein 7. 0 4. 8 433921 AA618174 gb : nq14fO1. s1 NCl_CGAP_Thy1 Homosapiens 7. 0 7. 0 418940 H17739 Hs. 288513 HumanDNAsequencefromcloneRP5-899C14 7. 0 7. 0 410765 A1694972 Hs. 66180 nucleosome assembly protein 1-like 2 7. 0 8. 0 457012 R41480 Hs. 302754 ESTs 6. 9 6. 9 416018 AW138239 Hs. 78977 pnoprotein convertae subUlisin/kexin t 6. 9 14. 0 445898 AF070623 Hs. 13423 Homosapiensclone24468mRNAsequence 6. 9 6. 9 415669 NM 005025 Hs. 78589 serine (or cysteine) proteinase inhibito 6. 9 10. 2 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheti 6. 9 6. 9 409031 AA376836 Hs. 288856 ESTs 6. 8 6. 8 409339 AB020686 Hs. 54037 ectonucleotide pyrophosphatase/phosphodi 6. 8 3. 6 436568 H12049 Hs. 91564 ESTs 6. 8 6. 8 442593 R39804 Hs. 31961 ESTs 6. 7 6. 7 437948 AA772920 Hs. 303527 ESTs 6. 7 24. 8 412266 N59006 Hs. 26133 ESTs 6. 6 30. 9 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (CIEBP), 6. 6 45. 2 442026 A1243749 Hs. 8074 brain-specific angiogenesis inhibitor 3 6. 5 6. 5 429946 R49390 Hs. 254129 KIAA1678 6. 4 4. 5 445279 R41900 Hs. 22245 ESTs 6. 4 6. 4 428414 AL049980 Hs. 184216 DKFZP564C152 protein 6. 4 6. 4 407868 NM 000950 Hs. 40637 proline-rich Gla (G-carboxyglutamic acid 6. 4 3. 3 434104 AF116691 Hs. 116459 hypothetical protein PR02198 6. 4 4. 0 443244 A1457235 Hs. 166479 ESTs 6. 3 3. 0 442042 Api990506 Hs. 8077 Homo sapiens mRNA ; cDNADKFZp547E184 (fr 6. 2 6. 2 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 6. 2 43. 2 428536 AIt43139 Hs. 2288 visinin4ike 1 6. 0 22. 1

415114 D60468 Hs. 94181 ESTs 6. 0 6. 0 448958 AB020651 Hs. 22653 KIAA0844 protein 5. 9 5. 9 431467 N71831 Hs. 256398 Homo sapiens mRNA ; cDNA DKFZp434E0528 (f 5. 9 6. 0 447138 Api439112 Hs. 93828 ESTs, Weakly similar to 2109260A B cell 5. 8 5. 8 414545 AA149287 Hs. 76605 ESTs 5. 8 3. 6 418202 N48521 Hs. 26549 KIAA1708 protein 5. 8 5. 8 410389 AW954049 Hs. 8177 ESTs, Weakly similar to PIHUB6 salivary 5. 7 9. 6 444124 R43097 Hs. 6818 ESTs 5. 7 9. 3 408065 AW954272 gb : EST366342 MAGE resequences, MAGC Homo 5. 6 5. 6 448533 AL119710 Hs. 21365 nucleosome assembly protein 14ike 3 5. 6 9. 6 425523 AB007948 Hs. 158244 KIAA0479 protein 5. 6 35. 0 459697 AA406062 Hs. 98002 ESTs 5. 6 5. 4 408428 NM_014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 5. 6 5. 6 420111 AA255652 gb : zs21h11. r1 NCI CGAP_GCB1 Homosapiens 5. 5 3. 2 450149 AW969781 Hs. 132863 Zic family member 2 (odd-paired Drosophi 5. 4 5. 4 424918 R13982 Hs. 169309 myelin-associated oligodendrocyte basic 5. 3 5. 3 438202 AW169287 Hs. 22588 ESTs 5. 3 5. 3 448605 AL109678 Hs. 21597 Homo sapiens mRNA full length insert cON 5. 3 5. 3 425580 L11144 Hs. 1907 galanin 5. 3 3. 5 418866 T65754 gb : yc11cO7. s1 Stratagenelung (937210) H 5. 3 3. 8 430091 AB032958 Hs. 233023 KIAA1132 protein 5. 3 4. 9 448786 BE048842 Hs. 179075 HomosapienscDNAFW11881fis, cioneHE 5. 2 5. 2 427283 AL119796 Hs. 174185 ectonucleoGde pyrophosphataselphosphodi 5. 2 3. 0 415666 H72693 gb : yu03c11. r1 Soares fetal liver spleen 5. 2 5. 2 410240 AL157424 Hs. 61289 synaptoianin 2 5. 2 4. 6 428784 Y12851 Hs. 193470 purinergicreceptorP2X, ligand-gatedio 5. 2 7. 7 446692 Z44514 Homo sapiens mRNA for K) AA1763 protein. 5. 2 33. 0 428508 BE252383 Hs. 184668 SBB131 protein 5. 2 4. 1 446353 A1290919 Hs. 153661 ESTs 5. 1 5. 1 423135 N67655 Hs. 26411 ESTs 5. 1 8. 2 437331 AL353933 Hs. 21710 hypothetical protein DKFZp761G0313 5. 1 5. 1 413988 M81883 Hs. 324784 glutamate decarboxylase 1 (brain, 67kD) 5. 1 5. 1 429859 NM 007050 Hs. 225952 protein tyrosine phosphatase, receptor t 5. 1 5. 1 411379 Al816344 Hs. 12554 ESTs, WeaklysimilartoNPL4_HUMANNUCLE 5. 0 11. 2 408068 AW148652 Hs. 167398 ESTs 5. 0 5. 0 415734 NM 014747 Hs. 78748 KIAA0237 gene product 5. 0 27. 4 439607 BE540565 Hs. 159460 ESTs 5. 0 5. 6 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 4. 9 29. 3 414631 AW970130 Hs. 65406 ESTs 4. 9 4. 9 437117 AL049256 Hs. 122593 ESTs 4. 9 3. 8 418527 AA450386 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 4. 9 4. 9 425073 W39609 Hs. 22003 solute carrier family 6 (neurotransmitte 4. 9 4. 9 455364 H72176 Hs. 4273 hypothetical protein FLJ13159 4. 9 4. 9 443150 A1034467 Hs. 34650 ESTs 4. 9 7. 6 422411 AW749443 Hs. 22511 ESTs 4. 9 12. 0 414931 AK000342 Hs. 77646 Homo sapiens mRNA ; cDNA DKFZp761M0223 (f 4. 9 3. 4 430456 AA314998 Hs. 241503 hypothetical protein 4. 8 4. 7 428186 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 4. 8 3. 9 433516 AA595802 Hs. 33410 ESTs, Weak ! y simitar to T17279 hypotheti 4. 8 4. 8 427287 NM014903 Hs. 174188 KIAA0938 protein 4. 8 4. 8 416101 R24854 Hs. 268806 ESTs 4. 8 3. 3 447252 R90916 Hs. 12449 Homo sapiens transmembrane protein HTMP1 4, 8 3. 2 458268 AA428403 Hs. 106131 ESTs 4. 7 3. 9 440105 AA694010 Hs. 6932 Homo sapiens clone 23809 mRNA sequence 4. 7 8. 2 445102 AW204610 Hs. 22270 ESTs 4. 7 19. 2 419643 F06066 Hs. 91791 chromosome 11 open reading frame 25 4. 7 4. 7 414949 C15314 Hs. 323349 ESTs 4. 7 3. 8 453534 Nom314796 Hs. 33187 KIAA0748 gene product 4. 7 4. 7 445729 H21066 Hs. 13223 HomosapiensmRNAfulilengthinsertcDN 4. 7 4. 0 451032 W03692 Hs. 323079 Homo sapiens mRNA ; cDNA DKFZp564P116 (fr 4. 7 4. 9 434792 AA649253 Hs. 132458 ESTs 4. 7 3. 8 447104 R19085 Hs. 210706 Homo sapiens cDNA FLJ 13182 fis, clone NT 4. 7 3. 0 430537 X62692 Hs. 2593 phosphodiesterase 6B, cGMP-specific, rod 4. 6 4. 6 453431 AF094754 Hs. 32973 glycine receptor, beta 4. 6 4. 6 453302 Nom-000838 Hs. 32945 glutamate receptor, metabotropic 1 4. 6 4. 6 429876 AB028977 Hs. 225974 KIAA1054 protein 4. 6 16. 8 451516 Api800515 Hs. 12024 ESTs 4. 6 6. 3 433670 AA604405 gb : no87h09. s1 NCI CGAP AA1 Homo sapiens 4. 6 3. 9 437380 AL359577 Hs. 112198 Homo sapiens mRNA ; cDNA DKFZp547M073 (fr 4. 5 3. 8 410366 A1267589 Hs. 302689 hypothetical protein 4. 5 10. 4 419191 U17195 Hs. 89666 A kinase (PRKA) anchor protein 6 4. 5 4. 5 429290 AF203032 Hs. 198760 neurofilament, heavy polypepGde (200kD) 4. 5 3. 3 424932 R14070 Hs. 315369 Homo sapiens cDNA : FLJ23075 fis, clone L 4. 5 10. 2 432736 AA788898 Hs. 179902 transporter-like protein 4. 4 4. 0 421952 AA300900 Hs. 98849 ESTs. Moderately similar to AF161511 1 H 4. 4 3. 2 428963 AW382682 Hs. 258208 Homo sapiens, clone MGC : 15606, mRNA, com 4. 3 3. 3 435040 A1932350 Hs. 152825 ESTs 4. 3 4. 7 451301 A1769514 Hs. 209890 EST 4. 3 4. 3 452381 H23329 Hs. 290880 ESTs, Weakly similar to ALU1HUMANALUS 4. 3 4. 3 410305 AF030409 Hs. 62185 solulecarierfamily9 (sodium/hydrogen 4. 3 7. 8 433109 N58907 Hs. 162430 EST 4. 3 3. 9 431342 AW971018 Hs. 21659 ESTs 4. 3 8. 0 447163 AW292770 Hs. 5542 DnaJ (Hsp40) homotog, subfamily C, membe 4. 3 3. 4

422414 AW875237 Hs. 13701 ESTs 4. 2 5. 3 439274 AF086092 Hs. 48372 ESTs 4. 2 18. 3 423589 AA328082 Hs. 209569 ESTs 4. 2 4. 2 429956 A1374651 Hs. 22542 ESTs 4. 2 3. 2 427317 AB028955 Hs. 175780 KIAA1032 protein 4. 2 5. 3 426847 S78723 Hs. 298623 5-hydroxytryptamine (serotonin) receptor 4. 1 7. 9 408206 AF041853 Hs. 43670 kinesin family member 3A 4. 1 4. 1 433803 A1823593 Hs. 27688 ESTs 4. 1 4. 1 413024 AF036268 Hs. 75149 SH3-domain GRB2-like 2 4. 1 4. 0 448117 H49129 Hs. 172982 ESTs 4. 1 4. 1 450600 BE079478 Hs. 24880 ESTs 4. 1 3. 9 429550 AW293055 Hs. 119357 ESTs 4. 1 6. 4 448681 AL109781 Hs. 21754 HomosapiensmRNAfulilengthinsertcDN 4. 0 7. 2 458694 F12832 Hs. 3610 ESTs 4. 0 4. 0 452197 AW023595 Hs. 232048 ESTs 4. 0 4. 0 423728 AW891294 Hs. 132136 solute carrier family 4, sodium bicarbon 4. 0 7. 9 429656 X05608 Hs. 211584 neurofilament, lightplypeptide (68kD) 4. 0 13. 1 448583 NM 015239 Hs. 21542 KA1035 protein 4. 0 4. 0 419863 AW952691 Hs. 93485 HomosapiensmRNA ; cDNADKFZp761D191 (fr 3. 9 21. 4 442412 R77677 Hs. 346644 ESTs 3. 9 3. 9 424001 W67883 Hs. 137476 paternally expressed 10 3. 9 5. 4 440293 Ago04193 Hs. 22123 ESTs 3. 9 3. 9 422890 Z43784 ankyr 3, node of Ranvier (ankyrin G) 3. 9 3. 6 426054 U12431 Hs. 166109 ELAV (embryonic lethal, abnormal vision, 3. 9 3. 9 412949 A1471639 Hs. 71913 ESTs 3. 8 3. 7 427457 AW779105 Hs. 164682 ESTs 3. 8 11. 1 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) 3. 8 4. 4 442676 A1733585 Hs. 130897 ESTs 3. 8 3. 8 434998 AW975157 Hs. 26037 ESTs 3. 7 3. 7 424945 A1221919 hypothetical protein FLJ10582 3. 7 30. 5 415257 F03016 Hs. 27513 ESTs 3. 7 8. 6 407886 AW969688 Hs. 100826 ESTs 3. 7 20. 2 400844 NM003105* : Homo sapiens sortilin-related 3. 7 3. 1 456765 A1497900 Hs. 33067 ESTs 3. 7 3. 7 430287 AW182459 Hs. 125759 ESTs, WeaklysimilartoLEU5_HUMANLEUKE 3. 6 7. 6 452667 T87219 Hs. 13219 ESTs 3. 6 3. 6 436773 AW078629 PC4 and SFRS1 interacting protein 1 3. 6 3. 6 424120 T80579 Hs. 290270 ESTs 3. 6 14. 7 446574 A1310135 Hs. 335933 ESTs 3. 6 3. 5 432453 AI885537 Hs. 27172 ESTs, Moderately similar to PC4259 fern 3. 6 3. 9 408119 W26213 Hs. 101672 ESTs, WeaklysimilartoT00331hypotheG 3. 6 3. 6 449093 AB035356 Hs. 22998 neurexin 1 3. 6 3. 6 439239 A1031540 Hs. 235331 ESTs 3. 6 49. 5 451625 R56793 Hs. 106576 alanine-glyoxylate aminotransferase 2-li 3. 6 4. 1 435059 Z45270 Hs. 235873 hypotheGcal protein FLJ22672 3. 6 4. 8 423346 A1267677 Hs. 127416 synaptoianin 1 3. 6 20. 1 442738 AW002370 Hs. 131055 ESTs, Weakly similar to NPM HUMAN NUCLEO 3. 5 3. 5 442106 AW205881 Hs. 326728 ESTs 3. 5 3. 2 449117 AW449310 Hs. 210262 ESTs, Weakly similar to HSS2_HUMAN HEPAR 3. 5 3. 5 405819 NM002578 : Homosapiens p21 (CDKN1A)-acti 3. 5 13. 5 452311 AW304029 Hs. 252744 ESTs 3. 5 3. 5 448902 Z45998 Hs. 22543 HomosapiensmRNA ; cDNADKFZp76111912 (f 3. 5 21. 8 410224 M55513 Hs. 150208 potassium voltage-gated channel, shaker-3. 4 3. 4 400098 Eos Control 3. 4 3. 4 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 3. 4 5. 9 437268 A1754847 Hs. 227571 regulator of G-protein signalling 4 3. 4 14. 0 443682 Ai383061 Hs. 47248 ESTs, Highly similar to similar to Cdc14 3. 4 3. 3 417417 F05745 Hs. 89512 ATPase, Ca transporting, plasma membrane 3. 3 17. 1 419629 AB020695 Hs. 91662 KIAA0888 protein 3. 3 13. 4 419852 AW503756 Hs. 286184 hypothetical protein dJ551D2. 5 3. 3 4. 1 417063 N50515 Hs. 45061 ESTs 3. 3 3. 3 435071 D60683 Hs. 35495 ESTs 3. 3 3. 3 446377 AW014022 Hs. 170953 ESTs 3. 3 3. 3 412453 R20205 Hs. 75236 ESTs 3. 3 3. 3 450561 R49674 Hs. 25909 ESTs 3 3 3 3 423829 R44107 Hs. 240905 ESTs 3. 3 4. 4 415527 F11624 gb : HSC2ZD101normalizedinfant braincDN 3. 3 3. 3 427386 AW836261 Hs. 6727 ESTs 3. 3 3. 3 425121 A1797511 Hs. 154679 synaptotagmin 1 3. 2 3. 9 452856 AF034799 Hs. 30881 protein tyrosine phosphatase, receptor t 3. 2 10. 7 442879 AF032922 Hs. 8813 syntaxin binding protein 3 3. 2 3. 2 417284 N62889 Hs. 107242 Homo sapiens cDNA FW 12965 fis, clone NT 3. 2 3. 2 416805 F13271 Hs. 79981 Humanclone23560mRNAsequence 3. 2 6. 7 429477 Api275514 Hs. 6658 ESTs 3. 2 3. 2 453169 AB037815 Hs. 32156 K) AA1394 protein 3. 2 5. 7 408039 AA131424 Hs. 336636 ESTs 3. 2 3. 2 426269 H15302 Hs. 168950 Homo sapiens mRNA ; cDNA DKFZp566A1046 (f 12 22. 1 409746 NM 004794 Hs. 56294 RAB33A, member RAS oncogene family 3. 2 10. 6 416874 H98752 Hs. 42568 ESTs 3. 2 6. 0 453919 AW959912 Hs. 7076 KIAA1705 protein 3. 2 3. 2 444861 R46789 Hs. 76118 ubiquitin carboxyl-temminal esterae L1 3. 2 3. 2 433315 R96754 Hs. 239706 GRB2-associated binding protein 1 3. 2 3. 1 419103 Z40229 Hs. 96423 hypothetical protein FLJ23033 3. 2 8. 4

424140 Z48051 Hs. 141308 myelin oligodendrocyte glycoprotein 3. 2 56. 0 421790 AW896201 Hs. 22654 sodium channel, voltage-gated, type 1, a 3. 2 4. 1 432809 AA565509 Hs. 131703 ESTs 3. 1 9. 9 445225 Api216555 Hs. 202398 ESTs 3. 1 5. 5 424087 N69333 Hs. 143434 contact ! n1 3. 1 3. 1 437924 Al935344 Hs. 164118 ESTs, Weakly similar to SL51 HUMAN SODIU 3. 1 3. 2 419683 AA248897 Hs. 48784 ESTs 3. 1 5. 9 420173 AA256151 Hs. 22999 ESTs 3. 1 4. 1 411666 AF106564 Hs. 71346 neurofilament 3 (150kD medium) 3. 1 6. 6 416220 N49776 Hs. 170994 hypotheticai protein MGC10946 3. 1 4. 5 425138 H08849 Hs. 167464 glutamate receptor, ionotropic, N-methyl 3. 1 4. 2 422234 AF119818 Hs. 113287 discs, large (Drosophila) homolog-associ 3. 1 3. 1 445194 A1215667 Hs. 175044 ESTs 3. 1 3. 1 438054 AA776626 Hs. 169309 ESTs 3. 1 10. 2 432149 AW614326 Hs. 133483 ESTs, Weakly similar to T34549 probable 3. 1 12. 2 445725 AK000956 Hs. 13209 hypothetical protein FLJ10094 3. 0 3. 0 414245 BE148072 Hs. 75850 WAS protein family, member 1 3. 0 11. 7 447673 A1823987 Hs. 182285 ESTs 3. 0 3. 0 428392 H10233 Hs. 2265 secretory granule, neuroendocrine protei 3. 0 42. 3 418410 AA811441 Hs. 107393 chromosome 3 open reading frame 4 3. 0 3. 9 429024 AI652297 Hs. 119302 complement-clq tumor necrosis factor-rel 3. 0 3. 7 426919 AL041228 ELAV (embryonic lethal, abnormal vision, 3. 0 9. 0 424724 T06532 Hs. 287709 Homo sapiens cDNA : FU22674 fis, clone H 3. 0 3. 0 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 3. 0 10. 0 408947 AL080093 Hs. 49117 HomosapiensmRNA ; cDNA DKFZp564N1662 (f 3. 0 13. 5 426325 D28114 Hs. 169309 myetin-associated ofigodendrocyte basic 2. 9 81. 1 429006 AA443143 Hs. 50929 hypothetical protein FLJ13842 2. 9 6. 6 410711 AB002316 Hs. 65746 KIAA0318 protein 2. 9 6. 1 415486 H12214 Hs. 13284 ESTs, Weakly similar to 2109260A B cell 2. 9 15. 7 424474 AA308883 Hs. 148680 calcyon ; D1dopamine receptor-interactin 2. 9 3. 6 448299 AA497044 Hs. 20887 hypothetical protein FLJ10392 2. 9 11. 5 419518 U79289 Hs. 90798 Human clone 23695 mRNA sequence 2. 9 3. 6 426529 AF090100 Hs. 170241 Homo sapiens clone IMAGE 23915 2. 9 5. 1 430347 NM002039 Hs. 239706 GR82-associated binding protein 1 2. 9 3. 2 429401 AW296102 Hs. 99272 ESTs, Weakly similar to S32567 A4 protei 2. 9 6. 1 450154 R15891 Hs. 281587 Human (clone CTG-A4) mRNA sequence 2. 9 5. 9 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 2. 8 28. 5 424790 AL119344 Hs. 13326 ESTs, Weakly similar to 2004399A chromos 2. 8 23. 1 416836 D54745 Hs. 80247 cholecystokinin 2. 8 6. 8 449277 AA001064 Hs. 43670 ESTs 2. 8 8. 5 451952 AL120173 Hs. 301663 ESTs 2. 7 19. 2 408554 AA836381 Hs. 315111 nuclear receptor co-repressor/HDAC3 comp 2. 7 3. 7 413408 R51793 Hs. 1440 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2. 7 3. 0 410343 AA084273 Hs. 76561 ESTs, Weakly similar to S47072 finger pr 2. 7 3. 2 420489 AA815089 Hs. 193513 ESTs 2. 7 4. 1 447359 NM 012093 Hs. 18268 adenylate kinase 5 2. 7 17. 2 423731 T08814 gb : EST06706 Infant Brain, Bento Soares H 2. 7 4. 0 409953 AA332277 Hs. 57691 cadherin 18, type 2 2. 7 5. 5 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 2. 7 11. 5 449714 AB033015 Hs. 23941 KIAAI 189 protein 2. 7 7. 5 424922 BE386547 Hs. 217112 hypothetical protein MGC10825 2. 7 3. 7 432447 X92681 Hs. 2998 contacfin 2 (axonal) 2. 7 4. 1 420071 AB028985 Hs. 94806 ATP-binding cassette, sub-family A (ABC1 2. 7 5. 1 438068 A1927209 Hs. 306210 Homo sapiens cDNA : FLJ23133 fis, clone L 2. 6 5. 1 418512 AW498974 diacylglycerol kinase, zeta (104kD) 2. 6 7. 9 447761 AF061573 Hs. 19492 pnotocædhenn 8 2. 6 6. 3 448743 AB032962 Hs. 21896 KIAA1136 protein 2. 6 23. 2 408547 AA574291 Hs. 57837 ESTs 2. 6 4. 0 426380 Api291267 Hs. 149990 ESTs 2. 6 6. 9 420898 AB002379 Hs. 100113 KIAA0381 protein 2. 6 3. 7 440357 AA379353 Hs. 20950 phospholysine phosphohisGdine inorganic 2. 6 3. 7 424572 M19650 2', 3'-cyclic nucleotide 3'phosphodieste 2. 6 5. 9 418338 Nom002522 Hs. 84154 neuronal pentraxin 1 2. 5 6. 1 427658 H61387 Hs. 30868 nogo receptor 2. 5 3. 0 410359 R38624 Hs. 106313 ESTs 2. 5 6. 3 449717 AB040935 Hs. 23954 cerebral cell adhesion molecule 2. 5 4. 5 424458 M29273 Hs. 1780 myelin associated glycoprotein 2. 5 10. 1 450133 AW969769 Hs. 105201 ESTs 2. 5 40. 5 428976 AL037824 Hs. 194695 ras homolog gene family, member 1 2. 5 17. 4 454293 H49739 Hs. 134013 ESTs, ModeratelysimilartoHK61_HUMANH 2. 5 9. 5 408447 AK002089 Hs. 45080 Homo sapiens cDNA FLJ11227 fis, clone PL 2. 5 3. 9 414683 S78296 Hs. 76888 hypothetical protein MGC12702 2. 5 7. 1 422927 AW247388 Hs. 301423 calcium binding protein 1 (calbrain) 2. 5 3. 0 449568 AL157479 Hs. 23740 KIAA1598 protein 2. 5 3. 6 454053 AW023006 Hs. 27172 ESTs, Moderately similar to PC4259 fern 2. 5 3. 6 428495 NM 013279 Hs. 184640 hypothetical protein MGC10781 2. 5 3. 2 431096 AA324358 Hs. 249227 Homo sapiens DNA, cosmid clones TN62 and 2. 4 3. 6 452371 R40990 Hs. 21658 ESTs 2. 4 3. 3 424997 AL138167 Hs. 96920 ESTs 2. 4 6. 2 450310 N62341 Hs. 94116 ESTs 2. 4 3. 6 452898 AA814497 Hs. 78792 ESTs 2. 4 3. 9 436734 A1937612 Hs. 273758 hypothetical protein FU23112 2. 4 4. 7 421931 NM_000814 Hs. 1440 gamma-aminobutyric acid (GABA) A recepto 2. 4 3. 1

439428 AA835825 Hs. 190490 ESTs 2. 4 3. 0 445255 NM 014841 Hs. 12477 synaptosomal-associated protein, 91 kDa 2. 4 8. 1 436420 AA443966 Hs. 31595 ESTs 2. 4 3. 7 408822 AW500715 Hs. 57079 Homo sapiens cDNA FU 13267 fis, clone OV 2. 4 3. 0 451407 AA131376 Hs. 343809 fibroblast growth factor 12B 2. 4 7. 2 419757 AA773820 Hs. 63970 ESTs 2. 4 3. 3 446100 AW967109 Hs. 13804 hypothetical protein dJ462023. 2 2. 4 3. 6 439199 R40373 Hs. 26299 ESTs 2. 3 9. 5 427627 R87582 Hs. 179915 guanine nucleoSde binding protein (G pr 2. 3 5. 6 454048 H05626 Hs. 6921 ESTs 2. 3 9. 9 412675 AA460716 Hs. 9788 hypothetical protein MGC10924 similar to 2. 3 3. 3 434811 AW971205 Hs. 114280 ESTs 2. 3 6. 7 431677 AK000496 Hs. 306989 hypotheticalprotein FU20489 2. 3 3. 1 451386 AB029006 Hs. 26334 spastic paraplegia 4 (autosomal dominant 2. 3 3. 1 447028 A1973128 Hs. 167257 brain link protein-1 2. 3 5. 6 451050 AW937420 Hs. 69662 ESTs 2. 3 4. 4 437397 AA349847 Hs. 4221 hypothetical protein DKFZp761H039 2. 3 4. 8 408838 A1669535 Hs. 40369 ESTs 2. 3 3. 0 408777 U71204 Hs. 47626 Ric (Drosophila)-like, expressed in neur 2. 3 3. 8 453924 R49295 Hs. 24886 ESTs 2. 3 13. 4 422709 AA315331 Hs. 153485 ESTs 2. 3 4. 4 438911 AF085841 Hs. 301920 ESTs 2. 3 3. 3 439108 AW163034 Hs. 6467 synaptogyrin 3 2. 2 6. 9 420297 A1628272 Hs. 88323 ESTs, WeaklysimilartoALU1_HUMANALUS Z2 4. 1 404819 NMJM2688' : Homo sapiens peanut (Drosophi 2. 2 5. 8 422544 AB018259 Hs. 118140 K) AA0716 gene product 2. 2 11. 8 433597 AA708205 Hs. 100343 ESTs 2. 2 11. 0 440152 AB002376 Hs. 7006 KIAA0378 protein 2. 2 14. 2 418375 NM 003081 Hs. 84389 synaptosomal-associated protein, 25kD 2. 2 82. 9 409892 AW956113 Hs. 7149 gb : EST368183 MAGE resequences, MAGD Homo 2, 2 4. 2 425287 R88249 Hs. 155524 peanut (Drosophila)-like 2 2. 2 6. 0 433657 AI244368 Hs. 8124 PH domain containing protein in retina 1 2. 2 5. 0 438703 A1803373 Hs. 31599 ESTs 2. 2 6. 2 428845 AL157579 Hs. 153610 KIAA0751 gene product 2. 2 6. 7 417865 AW086059 Hs. 6529 ESTs, Weakly similar to 178885 serinelth 2. 2 3. 5 425897 AA935315 Hs. 48965 Homo sapiens cDNA : FLJ21693 fis, clone C 2. 2 3. 2 419271 N34901 Hs. 238532 ESTs 2. 2 7. 5 448548 R13209 Hs. 21413 solutecanierfamily12, (ptasium-chl 2. 2 7. 3 439415 F05538 Hs. 4273 ESTs 2. 2 31. 3 415170 R44386 Hs. 164578 ESTs 2. 2 10. 9 423641 AL137256 Hs. 130489 ATPase, aminophospholipid transporter-li 2. 1 6. 2 443728 A1083876 Hs. 148383 ESTs 2. 1 4. 1 452108 AW135982 Hs. 203013 hypothetical protein FLJ12748 2. 1 5. 7 429037 X81895 Hs. 194765 H. sapiens GENX-5624 mRNA, 3'UTR 2. 1 7. 1 418900 BE207357 Hs. 3454 KIAA1821 protein 2. 1 4. 3 421268 A1126821 Hs. 30514 ESTs 2. 1 4. 2 446372 AB020644 Hs. 14945 longfattyæy-CoAsynthetae2gene 2. 1 15. 6 425741 AF052152 Hs. 159412 Homosapiensclone24628mRNAsequence 2. 1 6. 5 450214 BE439763 Hs. 227571 regulator of G-protein signalling 4 2. 1 3. 3 452738 AL133800 Hs. 7086 hypothetical protein MGC12435 2. 1 3. 5 447877 A1435184 Hs. 164252 ESTs 2. 1 5. 1 422421 AA325138 Hs. 235873 hypothetical protein FLJ22672 2. 1 8. 3 432882 NM 013257 Hs. 279696 serunilglucocorficoid regulated kinase-li 2. 1 4. 2 410631 AA086469 Hs. 47171 ESTs 2. 1 5. 8 407808 AA663559 Hs. 279789 histone deacetylase 3 2. 1 5. 7 424379 Z42034 Hs. 93597 cyclin-dependentkinae5, egulatorysu 2. 1 3. 2 448410 AK000227 Hs. 21126 hypothetical protein FU20220 2. 1 3. 0 433932 AW954599 Hs. 169330 neuronal protein 2. 1 6. 9 425130 AA448208 Hs. 99163 ESTs 2. 1 3. 1 402027 Target Exon 2. 0 3. 5 435191 R15912 Hs. 4817 Homosapiensclone24461mRNAsequence 2. 0 7. 5 420547 AF155140 Hs. 98738 gonadotropin-regulated tesEcular RNA he 2. 0 10. 7 404541 NM 030795 : Homo sapiens stathmin-like 4 (2. 0 6. 0 420050 AL118615 Hs. 94653 neurochondnn 2. 0 6. 5 417868 A1078534 Hs. 122592 ESTs 2. 0 5. 6 416602 NM006159 Hs. 79389 net (chicken)-like 2 2. 0 3. 2 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 2. 0 4. 2 439340 AB032436 Hs. 6535 brain-specific Na-dependent inorganic ph 2. 0 6. 3 429900 AA460421 Hs. 30875 ESTs 2. 0 4. 2 437762 T78028 Hs. 154679 synaptotagmin 1 2. 0 4. 6 425172 AA447729 Hs. 12714 ESTs 2. 0 3. 1 419587 S62907 Hs. 91343 gamma-aminobutyricacid (GABA) A recepto 2. 0 3. 1 451734 NM_006176 Hs. 26944 neurogranin (protein kinase C substrate, 2. 0 4. 9 423603 AB007880 Hs. 129883 Homo sapiens KIAA0420 mRNA, complete cds 2. 0 4. 3 438277 AL022326 Hs. 6139 synaptogyrin 1 2. 0 3. 4 423767 H18283 Hs. 132753 F-boxonlyprotein2 2. 0 3. 2 434933 R91095 Hs. 4276 KIAA1701 protein 2. 0 6. 1 426575 M74826 Hs. 170808 giutamatedecarboxyiase 2 (pancreatic is 2. 0 4. 6 TABLE 18B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers

Pkey CAT Number Accession 408065 103646 1 AW954272 A1003154 AA059300 AA046911 415527 1539393 1 F11624 Z43212 H08936 R56332 H09256 R52303 R13075 415666 1543492 1 H72693 R08673 H72694 F20990 R08580 418512 176394 1 AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074 AW890649 418866 179788 1 T65754 AA229857 AA229658 420111 190755-1 AA255652 AA280911 AW967920 AA2626B4 422890 222707 1 143784 Ri3382 AW572911 AA449369 H17037 R19603 AI632565 AW004030 BE502530 Z25032 AA805324 AA449241 AI651825 AI264863 AW196918 AA948267 AI953735 AI263703 AA319159 AW964436 AI903440 AW594171 A1867447 AW204071 AW956110 C15616 D81142 H17038 AW162343 T87230 A13 423731 231466_1 T08814 H19198 AL120536 M330218 AW961552 N47159 424572 24097_1 M19650 R18810 R18721 AW896146 AW889520 AA192362 AA176814 F12085 BE255264 BE251393 T65248 AA380585 AA380465 BE408684 AA459037 AW498869 AA776107 BE274289 D45269 M61958 AA378818 AW663180 AW672958 H08611 M78164 BE393721 AA348660 R36303 AW498662 AA019090 AA001 424945 245223J A ! 221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 A1341345 AW298800 AA724961 AA931158 A ! 741227 A1806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N504B3 Z39997 Al492961 Al361526 F04002M452141 T23551 Al472655 Al193667 Al341 426919 273507 i AL041228 D824 D61361 AI203314 AI990307 AW900295 A1018308 AW087473 AW 183530 AA393346 H50055 AA935601 433670 372721_1 M604405 BE062234 AW748386 433921 377350J AA618174A) 114549R36464R36465 433940 37787 1 H05129 N63433 AI651350 AA984734 A1368716 N40915 AI989705 F09042 T03905 R88588 AF112220 436773 426857 1 AW078629 AI857375 N64357 AA731069 446692 689623 1 Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983 TABLE 18C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. NLposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 400844 9188605 Plus 24746-24872, 25035-25204 402027 7622350 Plus 5164551888, 52917-53005 404541 8318559 Plus 103456-103664 404819 4678240 Plus 16223-16319, 16427-16513, 1673&16859, 16941-17075, 17170-t7287, 17389-17529, 18261-18357, 1844&18578 405560 183148 Plus 5495-5655. 6077-6241, 6495-6692 405819 4007557 Plus 2830-2967 406311 9211559 Minus 137114-139033 TABLE 19A : ABOUT 356 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS Table 19A lists about 356 CNS-enriched genes significantly down-regulated in glioblastoma compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to average glioblatoma wa greater than or equal to 2. The'average'normal CNS level was set to the 85t pen entile amongst various normal CNS tissues. The'average'glioblastoma level was set to the 85b percenGle amongst various tumor samples. To enrich for CNS specific genes, the ratio of'average'CNS to'average'non-CNS normai adult Gssues was calculated to be greater than or equal to 3. The'average'CNS level was set to the 85 percentile amongst various CNS tissues. The'average normal non-CNS adult tissue level was set to the 95t percentile amongst various non-CNS normal tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10t pencenUle value amongst non-malignant tissues was subtracted from both the numerator and the denominator before the ratios were evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene Utle RI : Ratio of CNS to Gioblastoma R2 : Ratio of CNS to NON-CNS NORMAL ADULT TISSUES Pkey ExAccn UnigenelD Unigene Titte R1 R2 425489 M58594 Hs. 1905 prolacbn 24. 8 10. 5 410330 AW023630 Hs. 159425 ESTs 23. 4 23. 4 430538 AB032435 Hs. 242821 differentiation-associated Na-dependent 22. 6 22. 6 417275 X63578 Hs. 295449 parvalbumin 22. 4 6. 0 428505 AL035461 Hs. 2281 chromogranin B (secretogranin 1) 21. 8 21. 8 408040 Api266496 Hs. 22905 ESTs, Weakly similar to RHG6_HUMAN RHO-G 19. 4 19. 4 435145 Al277259 Hs. 116631 ESTs 18. 5 3. 8 407039 X00368 gb : Human prolæUn gene 5'region. 18. 1 18. 1 409263 AA069573 Hs. 50319 ESTs 16. 8 16. 8 432298 AL118812 Hs. 274293 HomosapiensmRNA ; cDNADKFZp761G1111 (f 15. 1 15. 1 424645 NM_014682 Hs. 151449 KIAA0535 gene product 15. 1 15. 1 416018 AW138239 Hs. 78977 proprotein convertase subtilisinlkexin t 14. 0 14. 0 405560 AW887701 hypothetica) protein FU20628 13. 9 8. 0 452022 AW072330 Hs. 293875 ESTs 13. 8 13. 8 413324 V00571 Hs. 75294 conicotropin releasing hormone 13. 2 13. 2 411498 NM014210 Hs. 70499 ecotropic viral integrafion site 2A 12. 9 19. 4 423449 A1497900 Hs. 33067 ESTs 12. 4 14. 5 433940 H05129 cyclic AMP-regulated phosphoprotein, 21 12. 0 12. 0 410657 AF063228 Hs. 65248 dynein, cytoplamic, intermediate polype 11. 5 11. 5 449078 AK001256 Hs. 22975 KIAA1576 protein 11. 0 16. 1 410635 D58863 Hs. 334372 chorionicsomatomammotropin hormone 1 (p 11. 0 6. 6 453165 S74727 Hs. 32042 asparloacylase (aminoacylase 2, Canavan 10. 7 10. 7 417167 AW206437 Hs. 4290 ESTs 10. 4 10. 4 420033 D59502 Hs. 292590 ESTs 10. 4 10. 4 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 10. 0 10. 0

418207 C14685 Hs. 34772 ESTs 9. 8 9. 8 417175 R44558 Hs. 94002 ESTs 9. 6 8. 9 444330 A1597655 Hs. 49265 ESTs 9. 1 9. 1 427322 AK002017 Hs. 176227 hypothetical protein FLJ11155 8. 9 8. 9 429096 AB011106 Hs. 196012 KIAA0534 protein 8. 6 8. 6 428652 AA584272 Hs. 336224 transmembrane protein with EGF-like and 8. 6 8. 6 419347 C15944 Hs. 90005 superiorcervical ganglia, neural specifi 8. 6 22. 2 410309 BE043077 Hs. 278153 ESTs 8. 5 8. 5 416851 AW963951 Hs. 85618 ESTs 8. 5 8. 5 427061 AB032971 Hs. 173392 KIAA1145protein 8. 4 8. 4 400438 AF185611 Hs. 115352 Target 8. 3 5. 1 440209 H05049 Hs. 247837 neuexin 3 8. 2 18. 7 422756 AA441787 Hs. 119689 g ! ycoproteinhomiones. alpha polypeptide 8. 1 5. 8 435648 H24347 Hs. 27524 ESTs 8. 1 8. 1 429470 Ai878901 Hs. 203862 guanine nucleofide binding protein (G pr 8. 0 8. 0 416133 NM1683 Hs. 89512 ATPase, Ca transporting, plasma membrane 8. 0 8. 0 408814 N62499 Hs. 176227 hyptheUcaiproteinFW11155 7. 9 8. 6 430004 U27768 Hs. 227571 regulator of G-protein signalling 4 7. 9 15. 7 436427 A1344378 Hs. 143399 ESTs 7. 8 7. 8 434367 AB020700 Hs. 3830 KIAA0893 protein 7. 8 5. 6 429876 AB028977 Hs. 225974 KIAA1054 protein 7. 8 16. 8 441005 Z41305 Hs. 303172 Homo sapiens mRNA ; cDNADKFZp547G133 (fr 7. 7 7. 7 442023 Api187878 Hs. 144549 ESTs 7. 7 5. 6 429033 NM 007374 Hs. 194756 sineocuGshomeobox (Dmsophila) homoio 7. 6 5. 5 450642 R39773 Hs. 7130 copine IV 7. 6 5. 6 437073 AI885608 Hs. 94122 ESTs 7. 5 7. 5 441264 AA927170 Hs. 23290 ESTs 7. 3 7. 3 424153 AA451737 Hs. 141496 MAGE-like 2 7. 3 5. 1 450474 AW872844 Hs. 117494 ESTs 7. 2 7. 2 450715 Api266484 Hs. 31570 ESTs. Weakly similar to KIAA1324 protein 7. 2 7. 2 415076 NM000857 Hs. 77890 guanylate cyclase 1, soluble, beta 3 7. 1 4. 8 423003 AL120077 Hs. 122967 kelch (Drosophila)-iike2 (Mayven) 7. 0 7. 0 433921 AA618174 gb : nq14fO1. s1 NU_CGAP_Thy1 Homosapiens 7. 0 7. 0 425352 NM 000939 Hs. 1897 proopiomelanocortin (adrenocorticotropin 6. 9 6. 1 457012 R4 f480 Hs. 302754 ESTs 6. 9 6. 9 445898 AF070623 Hs. 13423 Homosapiensclone24468mRNAsequence 6. 9 6. 9 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheti 6. 9 6. 9 409031 AA376836 Hs. 288856 ESTs 6. 8 6. 8 453590 AF150278 Hs. 33578 KIAA0820 protein 6. 6 22. 3 450181 H05254 Hs. 201198 ESTs 6. 6 7. 2 425580 L11144 Hs. 1907 galanin 6. 5 3. 5 445279 R41900 Hs. 22245 ESTs 6. 4 6. 4 428414 AL049980 Hs. 184216 DKFZP564C152 protein 6. 4 6. 4 434104 AF116691 Hs. 116459 hypotheticalproteinPR02198 6. 4 4. 0 443244 AI457235 Hs. 166479 ESTs 6. 3 3. 0 447750 Api422234 Hs. 143434 contain 1 6. 2 9. 8 415114 D60468 Hs. 94181 ESTs 6. 0 6. 0 450600 BE079478 Hs. 24880 ESTs 5. 9 3. 9 444458 BE041526 Hs, 31746 hypothetical protein DKFZp547F072 5. 9 7. 7 448958 AB020651 Hs. 22653 KIAA0844 protein 5. 9 5. 9 447138 Al439112 Hs. 93828 ESTs, Weakly similar to 2109260A Bcell 5. 8 5. 8 414545 AA149287 Hs. 76605 ESTs 5. 8 3. 6 410389 AW954049 Hs. 8177 ESTs, WeaklysimibrtoPIHUB6sabvay 56 96 450590 A1701507 Hs. 273740 ESTs 5. 6 3. 8 408428 NM 014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 5. 6 5. 6 442026 A1243749 Hs. 8074 brain-specific angiogenesis inhibitor 3 5. 5 6. 5 450149 AW969781 Hs. 132863 Zc family member 2 (odd-paired Drosophi 5. 4 5. 4 414699 Api815523 Hs. 76930 synuclein, alpha (nonA4componentofam 5. 3 4. 5 438202 AW169287 Hs. 22588 ESTs 5. 3 5. 3 448605 AL109678 Hs. 21597 Homo sapiens mRNA full length insert cDN 5. 3 5. 3 418866 T65754 gb : yc11c07. s1 Stratagene lung (937210) H 5. 3 3. 8 448786 BE048842 Hs. 179075 HomosapienscDNAFW11881 fis, cloneHE 5. 2 5. 2 406311 NM021979' : Homo sapiens heat shock 70kD 5. 2 11. 5 443682 Al383061 Hs. 47248 ESTs, Highly similar to similar to Cdc14 5. 2 3. 3 415666 H72693 gb : yu03c11. r1 Soares (etalliverspleen 5. 2 5. 2 416101 R24854 Hs. 268806 ESTs 5. 2 3. 3 428508 BE252383 Hs. 184668 SBB131 protein 5. 2 4. 1 419318 AW969742 Hs. 291005 ESTs 5. 2 3. 1 439238 N47305 Hs. 302161 ESTs 5. 1 5. 3 446353 A1290919 Hs. 153661 ESTs 5. 1 5. 1 412049 N53437 Hs. 18268 adenylate kinase 5 5. 1 10. 7 437331 AL353933 Hs. 21710 hypothetical protein DKFZp761G0313 5. 1 5. 1 413988 M81883 Hs. 324784 glutamate decarboxylase t (brain, 67kD) 5. 1 5. 1 408068 AW148652 Hs. 167398 ESTs 5. 0 5. 0 414631 AW970130 Hs. 65406 ESTs 4. 9 4. 9 418527 AA450386 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 4. 9 4. 9 425073 W39609 Hs. 22003 solute carrier family 6 (neurotransmitte 4. 9 4. 9 427224 AL135554 Hs. 101937 sine oculis homeobox (Drosophila) homolo 4. 9 3. 9 433516 AA595802 Hs. 33410 ESTs, Weakly similar to T17279 hypotheti 4. 8 4. 8 427287 NM 014903 Hs. 174188 KIM0933 protein 4. 8 4. 8 447252 R90916 Hs. 12449 HomosapienstransmembraneproteinHTMP1 4. 8 3. 2 424932 R14070 Hs. 315369 Homo sapiens cDNk-FU23075 fis, clone L 4. 7 10. 2 419643 F06066 Hs. 91791 chromosome 11 open reading frame 25 4. 7 4. 7

414949 C15314 Hs. 323349 ESTs 4 7 3. 8 453534 NMJ) 14796 Hs. 33187 KIAA0748 gene product 4. 7 4. 7 430537 X62692 Hs. 2593 phosphodiesterase 6B, cGMP-specific, rod 4. 6 4. 6 453431 AF094754 Hs. 32973 glycine receptor, beta 4. 6 4. 6 453302 NM 000838 Hs. 32945 glutamate receptor, metabotropic 1 4. 6 4. 6 447104 R19085 Hs. 210706 Homo sapiens CDNA FU 13182 fis, clone NT 4. 6 3. 0 418202 N48521 Hs. 26549 KIAA1708 protein 4. 6 5. 8 419191 U17195 Hs. 89666 A kinase (PRKA) anchor protein 6 4. 5 4. 5 459080 AW192083 Hs. 290855 ESTs 4. 5 13. 5 451783 R42554 Hs. 210862 T-box, brain, 1 4. 4 11. 2 421952 AA300900 Hs. 98849 ESTs, Moderately similar to AF161511 1 H 4. 4 3. 2 451050 AW937420 Hs. 69662 ESTs 4. 4 4 4 423728 AW891294 Hs. 132136 solutecarjerfamily4, sodiumbicarbon 4. 4 7. 9 447746 AW015920 Hs. 161359 ESTs 4. 3 9. 9 451301 A1769514 Hs. 209890 EST 4. 3 4. 3 452381 H23329 Hs. 290880 ESTs, Wea'<ysimilartoALU1_HUMANAWS 4. 3 4. 3 433109 N58907 Hs. 162430 EST 4. 3 3. 9 412155 R38167 Hs. 12449 HomosapienstransmembraneproteinHTMP1 4. 3 27. 9 426365 AA376667 Hs. 10283 RNA binding motif protein 88 4. 3 4. 1 423589 AA328082 Hs. 209569 ESTs 4. 2 4. 2 432453 Al885537 Hs. 27172 ESTs, ModeratelysimilarbPC4259fem 4. 2 3. 9 420489 AA815089 Hs. 193513 ESTs 4. 1 4. 1 427457 AW779105 Hs. 164682 ESTs 4. 1 11. 1 408206 AF041853 Hs. 43670 kinesin family member 3A 4. 1 4. 1 433803 A1823593 Hs. 27688 ESTs 4. 1 4. 1 407868 NM000950 Hs. 40637 proline-rich Gia (G-carboxyglutamic æid 4. 1 3. 3 448117 H49129 Hs. 172982 ESTs 4. 1 4. 1 442106 AW205881 Hs. 326728 ESTs 4. 1 3. 2 450757 BE081050 Hs. 31570 ESTs, Weakly similar to KIAAI 324 protein 4. 0 3. 2 442042 A1990506 Hs. 8077 Homo sapiens mRNA ; cDNADKFZp547E184 (fr 4. 0 6. 2 458694 F12832 Hs. 3610 ESTs 4. 0 4. 0 452197 AW023595 Hs. 232048 ESTs 4. 0 4. 0 448583 NM 015239 Hs. 21542 Kit1035 protein 4. 0 4. 0 418940 H17739 Hs. 288513 Human DNA sequence from clone RP5-899C14 3. 9 7. 0 442412 R77677 Hs. 346644 ESTs 3. 9 3. 9 440293 Al004193 Hs. 22123 ESTs 3. 9 3. 9 433670 AA604405 gb : no87hO9. s1 NCI_CGAP_M1 Homo sapiens 3. 9 3. 9 459697 AA406062 Hs. 98002 ESTs 3. 9 5. 4 429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 3. 9 3. 3 426054 U12431 Hs. 166109 ELAV (embryonic lethal, abnormal vision, 3. 9 3. 9 424001 W67883 Hs. 137476 paternally expressed 10 3. 8 5. 4 442676 A1733585 Hs. 130897 ESTs 3. 8 3. 8 410240 AL157424 Hs. 61289 synaptojanin 2 3. 8 4. 6 409339 AB020686 Hs. 54037 ectonucieoUde pyrophosphalase/phosphodi 3. 7 3. 6 434998 AW975157 Hs. 26037 ESTs 3. 7 3. 7 439450 R51613 Hs. 125304 ESTs 3. 7 8. 3 455364 H72176 Hs. 4273 hypotheGcal protein FLJ13159 3. 7 4. 9 400844 NM003105' : Homo sapiens sortlin-related 3, 7 3. 1 456765 A1497900 Hs. 33067 ESTs 3. 7 3. 7 452667 T87219 Hs. 13219 ESTs 3. 6 3. 6 436773 AW078629 PC4 and SFRS1 interacting protein 1 3. 6 3. 6 453220 AB033089 Hs. 32452 HomosapiensmRNAforKIM1263pnotein, 3. 6 19. 9 432149 AW614326 Hs. 133483 ESTs. Weakly similar to T34549 probable 3. 6 12. 2 408119 W26213 Hs. 101672 ESTs, Weakly similar to T00331 hypotheti 3. 6 3. 6 449093 AB035356 Hs. 22998 neurexin 1 3. 6 3. 6 426968 U07616 Hs. 173034 amphiphysin (SGff-Mann syndrome with br 3. 6 15. 3 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 3. 6 10. 0 442738 AW002370 Hs. 131055 ESTs, Weakly similar to NPM HUMAN NUCLEO 3. 5 3. 5 451032 W03692 Hs. 323079 HomosapiensmRNA ; cDNADKFZp$4P116 (fr 3. 5 4. 9 449117 AW449310 Hs. 210262 ESTs, WeaklysimilartoHSS2_HUMANHEPAR 3. 5 3. 5 416490 AF090116 Hs. 79348 regulator of G. protein signalling 7 3. 5 12. 5 412266 N59006 Hs. 26133 ESTs 3. 5 30. 9 452311 AW304029 Hs. 252744 ESTs 3. 5 3. 5 425649 U30930 Hs. 158540 UDP glycosyltransferase 8 (UDP-galactose 3. 5 38. 6 410224 M55513 Hs. 150208 potassium voltage-gated channel, shaker-3. 4 3. 4 451516 A1800515 Hs. 12024 ESTs 3. 4 6. 3 400098 Eos Control 3. 4 3. 4 424918 R13982 Hs. 169309 myelin-associated oligodendrocyte basic 3. 4 5. 3 452238 F01811 Hs. 345757 ESTs 3. 3 3. 8 417063 N50515 Hs. 45061 ESTs 3. 3 3. 3 443992 AW022228 Hs. 322922 ESTs 3. 3 13. 1 412453 R20205 Hs. 75236 ESTs 3. 3 3. 3 450561 R49674 Hs. 25909 ESTs 3. 3 3. 3 415527 F11624 gb : HSC2ZD101 normalized infant brain cDN 13 13 427386 AW836261 Hs. 6727 ESTs 3. 3 3. 3 423346 A1267677 Hs. 127416 synaptojanin 1 3. 2 20. 1 431342 AW971018 Hs. 21659 ESTs 3. 2 8. 0 448533 AL119710 Hs. 21365 nucleosome assembly protein 1-like 3 3. 2 9. 6 442879 AF032922 Hs. 8813 syntaxin binding protein 3 3. 2 3. 2 417284 N62889 Hs. 107242 Homo sapiens cDNA FW 12965 fis, clone NT 3. 2 3. 2 429477 Api275514 Hs. 6658 ESTs 3. 2 3. 2 410343 AA084273 Hs. 76561 ESTs, Weakly similar to S47072 finger pr 3. 2 3. 2 427317 AB028955 Hs. 175780 KIAA1032 protein 3. 2 5. 3

408039 AA131424 Hs. 336636 ESTs 3. 2 3. 2 428976 AL037824 Hs. 194695 ras homolog gene family, member) 3. 2 17. 4 420297 A1628272 Hs. 88323 ESTs. WeaklysimilartoALU1_HUMANALUS 3. 2 4. 1 453919 AW959912 Hs. 7076 KIAA1705 protein 3. 2 3. 2 428963 AW382682 Hs. 258208 Homo sapiens, clone MGC : 15606, mRNA, com 3. 2 3. 3 423829 R44107 Hs. 240905 ESTs 3. 1 4. 4 424087 N69333 Hs. 143434 contacting 3. 1 3. 1 419852 AW503756 Hs. 286184 hypothetical protein dJ551D2. 5 3. 1 4. 1 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 3. 1 43. 2 422234 AF119818 Hs. 113287 discs, large (Drosophila) homolog-associ 3. 1 3. 1 446692 Z44514 Homo sapiens mRNA for K1AA1763 protein, 3. 1 33. 0 437117 AL049256 Hs. 122593 ESTs 3. 1 3. 8 405819 NM_002578 : Homo sapiens p21 (CDKN1A)-acti 3. 1 13. 5 452752 AW044058 Hs. 33578 KIAA0820 protein 3. 1 13. 4 416220 N49776 Hs. 170994 hypothetical protein MGC10946 3. 1 4. 5 437380 AL359577 Hs. 112198 Homo sapiens mRNA ; cDNA OKFZp547M073 (fr 3. 0 3. 8 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 3. 0 5. 9 445725 AK000956 Hs. 13209 hypotheticalprotein FU10094 3. 0 3. 0 447673 Al823987 Hs. 182285 ESTs 3. 0 3. 0 427283 AL119796 Hs. 174185 ectonucleotide pyrophosphataselphosphodi 3. 0 3. 0 424724 T06532 Hs. 287709 Homo sapiens cDNA : FW22674 fis, clone H 3. 0 3. 0 408547 AA574291 Hs. 57837 ESTs 3. 0 4. 0 433315 R96754 Hs. 239706 GRB2-associated binding protein 1 3. 0 3. 1 439274 AF086092 Hs. 48372 ESTs 3. 0 18. 3 410765 A1694972 Hs. 66180 nucleosome assembly protein 14ike 2 3. 0 8. 0 458268 AA428403 Hs. 106131 ESTs 3. 0 3. 9 424641 AB001106 Hs. 151413 glia maturation factor, beta 3. 0 5. 6 441869 NM 003947 Hs. 8004 huntingGn-associated protein interactin 3. 0 14. 9 442593 R39804 Hs. 31961 ESTs 2. 9 6. 7 426380 A1291267 Hs. 149990 ESTs 2. 9 6. 9 428536 Api143139 Hs. 2288 visinin-like 1 2. 9 22. 1 417417 F05745 Hs. 89512 ATPase. Ca transporting, plasma membrane 2. 9 17. 1 411379 Api816344 Hs. 12554 ESTs, WeaklysimilartoNPL4_HUMANNUCLE 2. 9 11. 2 422414 AW875237 Hs. 13701 ESTs 2. 9 5. 3 428186 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 2. 9 3. 9 419518 U79289 Hs. 90798 Human clone 23695 mRNA sequence 2. 9 3. 6 426919 AL041228 ELAV (embryonic lethal, abnormal vision, 2. 9 9. 0 446544 AI631932 Hs. 7047 ESTs, Weakly similar to Unknown [H. sapie 2. 8 12. 4 422411 AW749443 Hs. 22511 ESTs 2. 8 12. 0 416874 H98752 Hs. 42568 ESTs 2. 8 6. 0 448902 Z45998 Hs. 22543 Homo sapiens mRNA ; cDNA DKFZp76111912 (f 2. 8 21. 8 430456 AA314998 Hs. 241503 hypothetical protein 2. 8 4. 7 429859 NM 007050 Hs225952 protein tyrosine phosphatase, receptor t 2. 8 5. 1 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 2. 8 13. 1 437948 AA772920 Hs. 303527 ESTs 2. 8 24. 8 440105 AA694010 Hs. 6932 Homosapiensclone23809mRNAsequence 2. 8 8. 2 414931 AK000342 Hs. 77646 Homo sapiens mRNA ; cDNA DKFZp761M0223 (f 2. 8 3. 4 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) 2. 8 4. 4 446574 Al310135 Hs. 335933 ESTs 2. 8 3. 5 422890 Z43784 ankyr nodeofRanvier (ankyrinG) 2. 8 3. 6 410711 AB002316 Hs. 65746 KIAA0318 protein 2. 7 6. 1 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (GBP), 2. 7 45. 2 408554 AA836381 Hs. 315111 nuclear receptor co-repressor/HDAC3 comp 2. 7 3. 7 434460 AA478486 Hs. 3852 KIAA0368 protein 2. 7 4. 8 431988 AC002302 Hs. 77202 protein kinase C, beta 1 2. 7 10. 5 447163 AW292770 Hs. 5542 DnaJ (Hsp40) homolog, subfamily C, membe 2. 7 3. 4 437924 A1935344 Hs. 164118 ESTs, WeaklysimilartoSL51_HUMANSODIU 2. 6 3. 2 424945 AI221919 hypotheGcal protein FU10582 2. 6 30. 5 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 2. 6 29. 3 447761 AF061573 Hs. 19492 protocadherin 8 2. 6 6. 3 425138 H08849 Hs. 167464 glutamate receptor, ionotropic, N-methyl 2. 6 4. 2 436568 H12049 Hs. 91564 ESTs 2. 6 6. 8 408065 AW954272 gb : EST366342 MAGE resequences, MAGC Homo 2. 6 5. 6 430287 AW182459 Hs. 125759 ESTs, Weakly similar to LEU5-HUMAN LEUKE 2. 6 7. 6 408777 U71204 Hs. 47626 Ric (Drosophila)-like, expressed in neur 2. 6 3. 8 420173 AA256151 Hs. 22999 ESTs 2. 6 4. 1 429550 AW293055 Hs. 119357 ESTs 2. 6 6. 4 438068 A1927209 Hs. 306210 Homo sapiens cDNA : FU23133 fis, clone L 2. 6 5. 1 424264 D80400 Hs. 239388 Human DNA sequence from clone RP1-304B14 2. 6 7. 3 432809 AA565509 Hs. 131703 ESTs 2. 6 9. 9 407886 AW969688 Hs. 100826 ESTs 2. 5 20. 2 445225 A1216555 Hs. 202398 ESTs 2. 5 5. 5 415257 F03016 Hs. 27513 ESTs 2. 5 8. 6 423135 N67655 Hs. 26411 ESTs 2. 5 8. 2 438283 A1458931 Hs. 37282 ESTs 2. 5 7. 5 454053 AW023006 Hs. 27172 ESTs, Moderately similar to PC4259 ferri 2. 4 3. 6 443150 A1034467 Hs. 34650 ESTs 2. 4 7. 6 429956 A1374651 Hs. 22542 ESTs 2. 4 3. 2 428392 H10233 Hs. 2265 secretory granule, neuroendocdne protei 2. 4 42. 3 437268 AI754847 Hs. 227571 regulator of G-protein signalling 4 2. 4 14. 0 426529 AF090100 Hs. 170241 Homo sapiens clone IMAGE 23915 2. 4 5. 1 430347 NM002039 Hs. 239706 GRB2-associated binding protein 1 2. 4 3. 2 422949 AA319435 gb : EST21657 Adrenal gland tumor Homo sap 2. 4 7. 4

451952 AL120173 Hs. 301663 ESTs 2. 4 19. 2 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 2. 4 28. 5 422927 AW247388 Hs. 301423 calcium binding protein 1 (calbrain) 2. 4 3. 0 425121 Api797511 Hs. 154679 synaptotagmin I 2. 4 3. 9 435059 Z45270 Hs. 235873 hypotheGcal protein FU22672 2. 4 4. 8 446377 AW014022 Hs. 170953 ESTs 2. 4 3. 3 452371 R40990 Hs. 21658 ESTs 2. 4 3. 3 419103 Z40229 Hs. 96423 hypothetical protein FW23033 2. 4 8. 4 427658 H61387 Hs. 30868 nogo receptor 2. 4 3. 0 446100 AW967109 Hs. 13804 hypothetical protein dJ462023. 2 2. 3 3. 6 439607 BE540565 Hs. 159460 ESTs 2. 3 5. 6 412949 Al471639 Hs. 71913 ESTs 2. 3 3. 7 419757 AA773820 Hs. 63970 ESTs 2. 3 3. 3 410037 AB020725 Hs. 58009 KIAA0918 protein 2. 3 12. 2 451386 AB029006 Hs. 26334 spastic paraplegia 4 (autosomal dominant 2. 3 3. 1 409953 AA332277 Hs. 57691 cadherin 18, type 2 2. 3 5. 5 419629 AB020695 Hs. 91662 KIAA0888 protein 2. 3 13. 4 434792 AA649253 Hs. 132458 ESTs 2. 3 3. 8 429006 AA443143 Hs. 50929 hypothetical protein FLJ13842 2. 3 6. 6 445194 A1215667 Hs. 175044 ESTs 2. 3 3. 1 422491 AA338548 Hs. 117546 neuronatin 2. 3 3. 6 415734 NM_014747 Hs. 78748 KlM0237geneproduct 2. 3 27. 4 434933 R91095 Hs. 4276 KIAA1701 protein 2. 2 6. 1 424922 BE386547 Hs. 217112 hypotheticalprotein MGC10825 2. 2 3. 7 426325 D28114 Hs. 169309 myelin-associated oligodendrocyte basic 2. 2 81. 1 424140 Z48051 Hs. 141308 myelinoligodendrocyteglycoprotein 22 56. 0 418410 AA811441 Hs. 107393 chromosome 3 open reading frame 4 2. 2 3. 9 409746 NM 004794 Hs. 56294 RAB33A, member RAS oncogene family 2. 2 10. 6 439239 Al031540 Hs. 235331 ESTs 2. 2 49. 5 450310 N62341 Hs. 94116 ESTs 2. 2 3. 6 453924 R49295 Hs. 24886 ESTs 2. 2 13. 4 411666 AF106564 Hs. 71346 neurofitament 3 (150kD medium) 2. 2 6. 6 404819 NM002688' : Homo sapiens peanut (Drosophi 2. 2 5. 8 449568 AL157479 Hs. 23740 KIAA1598 protein 2. 2 3. 6 419271 N34901 Hs. 238532 ESTs 2. 2 7. 5 424474 AA308883 Hs. 148680 calcyon ; D1 dopamine receptor-interacGn 2. 2 3. 6 438208 AL041224 Hs. 65379 ESTs 2. 2 5. 8 424458 M29273 Hs. 1780 myelin associated glycoprotein 2. 2 10. 1 421790 AW896201 Hs. 22654 sodium channel, voltage-gated, type 1, a 2. 2 4. 1 432882 NM_013257 Hs. 279696 serum/glucocorticoid regulated kinase-li 2. 1 4. 2 419863 AW952691 Hs. 93485 HomosapiensmRNA ; cDNADKFZp761D191 (fr 2. 1 21. 4 449277 AA001064 Hs. 43670 ESTs 2. 1 8. 5 420156 AW449258 Hs. 6187 ESTs 2. 1 12. 5 452738 AL133800 Hs. 7086 hypothetical protein MGC12435 2. 1 3. 5 410366 A1267589 Hs. 302689 hypothetical protein 2. 1 10. 4 452106 A1141031 Hs. 21342 ESTs 2. 1 3. 4 413409 Al638418 Hs. 1440 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2. 1 9. 4 423641 AL137256 Hs. 130489 ATPase, aminophospholipidtransprter-li 2. 1 6. 2 410909 AW898161 Hs. 53112 ESTs, ModeratelysimilartoALU8_HUMANA 2. 1 12. 5 410631 AA086469 Hs. 47171 ESTs 2. 1 5. 8 412675 AA460716 Hs. 9788 hypothetical protein MGC10924 similar to 2. 1 3. 3 448299 AA497044 Hs. 20887 hypothetical protein FU10392 2. 1 11. 5 444124 R43097 Hs. 6818 ESTs 2. 1 9. 3 408950 AA707814 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 2. 1 8. 5 432736 AA788898 Hs. 179902 transporter-like protein 2. 1 4. 0 429024 A1652297 Hs. 119302 complement-c1qtumornecrosisfætor-el 2. 1 3. 7 420071 AB028985 Hs. 94806 ATP-bindingcaseüe, sub-familyA (ABC1 2. 1 5. 1 408822 AW500715 Hs. 57079 Homo sapiens cDNA FW 13267 fis, clone OV 2. 1 3. 0 424790 AL119344 Hs. 13326 ESTs, Weakly similar to 2004399A chromos 2. 1 23. 1 426814 AF036943 Hs. 172619 myelin transcdpfion factor 1-like 2. 1 14. 2 425130 AA448208 Hs. 99163 ESTs 2. 1 3. 1 449714 AB033015 Hs. 23941 KIAAI 189 protein 2. 0 7. 5 439108 AW163034 Hs. 6467 synaptogyrin 3 2. 0 6. 9 415669 Nom005025 Hs. 78589 serine (or cysteine) proteinase inhibito 2. 0 10. 2 435040 A1932350 Hs. 152825 ESTs 2. 0-4. 7 440152 AB002376 Hs. 7006 KIAA0378 protein 2. 0 14. 2 445102 AW204610 Hs. 22270 ESTs 2. 0 19. 2 436734 Api937612 Hs. 273758 hypotheGcalproteinFW23112 2. 0 4. 7 437414 AW894071 Hs. 48448 hypothetical protein DKFZp547C176 2. 0 6. 4 418512 AW498974 diacylglycerol kinase, zeta (104kD) 2. 0 7. 9 453169 AB037815 Hs. 32156 KIAA1394 protein 2. 0 5. 7 420050 AL118615 Hs. 94653 neurochondrin 2. 0 6. 5 429900 AA460421 Hs. 30875 ESTs 2. 0 4. 2 432447 X92681 Hs. 2998 contactin 2 (axonal) 2. 0 4. 1 431677 AK000496 Hs. 306989 hypothetical protein FU20489 2. 0 3. 1 452856 AF034799 Hs. 30881 protein tyrosine phosphatase, receptor t 2. 0 10. 7 448681 AL109781 Hs. 21754 Homo sapiens mRNAfull length insert cDN 2. 0 7. 2 453754 AW972580 Hs. 172753 ESTs 2. 0 3. 4 422544 AB018259 Hs. 118140 KlM0716geneproduct 2. 0 11. 8 416836 D54745 Hs. 80247 cholecystokinin 2. 0 6. 8 454048 H05626 Hs. 6921 ESTs 2. 0 9. 9 425741 AF052152 Hs. 159412 Homo sapiens clone 24628 mRNA sequence 2. 0 6. 5

TABLE 19B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408065 103646_1 AW954272 Al003154 M059300 M046911 415527 15393931 F11624 Z43212 H08936 R56332 H09256 R52303 R13075 415666 1543492J H72693 R08673 H72694 F20990 R08580 418512 176394_1 AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074 AW890649 418866 179788_1 T65754 AA229857 AA229658 422890 222707 1 Z43784 R13382AW572911 M449369 H17037 R19603AI632565AW004030BE502530Z25032M805324M449241 A1651825AI264863AW196918 M948267 Al953735Al263703M319159 AW964436Al903440AW594171 Al867447 AW204071 AW956110 C15616 D81142 H17038AW162343 T87230 A13 422949 2231 W I AA319435 N56456 AA319377 AW96M2 T48452 AA894424 424945 245223 1 AI221919 Z1967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 A1341345 AW298800 AA724961 AA931158 A1741227 AI806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 AI492961 AI361526 F04002 AA452141 T23551 A1472655 A1193667 A1341 426919 2735071 AL041228 D82004 D61361 Al203314 Al990307 AW900295 A1018308 AW087473 AW183530 AA393346 H50055 AA935601 433670 372721 1 AA604405 BE062234 AW748386 433921 377350 1 AA618174Ai114549R36464R36465 433940 37787_1 H05129 N63433 A1651350 AA984734 A1368716 N40915 Api989705 F09042 T03905 R88588 AF112220 436773 4268571 AWW8629AI857375N64357AA731069 446692 689623 t Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983 TABLE 19C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et refers to the publication entitled The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nlposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 400844 9188605 Plus 24746-24872, 25035-25204 404819 4678240 Plus 1622316319, 16427-16513, 16736-16859. 16941-17075, 17170-17287, 1738917529, 18261-18357, 1944318578 405560 183148 Plus 54955655, 6077-6241, 6495-6692 405819 4007557 Plus 2830-2967 406311 9211559 Minus 137114-139033 TABLE 20A : ABOUT 328 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS Table 20A lists about 328 CNS-enriched genes significantly down-regulated in lower grade glioblastoma (LGG) compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to'average'LGG was greater than or equal to 2. The'average'normal CNS level was set to the 85t percenGle amongst various normal CNS tissues. The'average'LGG level was set to the 85t pencenUle amongst various tumor samples. To enrich for CNS specific genes, the ratio of'average'CNS to'average* non-CNS normal adult tissues was calculated to be greater than or equal to 3. The'average'CNS level was set to the 85^ percenúle anongst vanous CNS tissues. The'average'normal non-CNS adult 6ssue level was set to the 95'"percen6le amongst various non-CNS normal tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10'"percentile value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratios were evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene Gtle RI : Ratio of CNS compared to LOWER GRADE GLIOBLASTOMA R2 : Ratio of CNS compared to NON-CNS NORMAL ADULT TISSUE Pkey ExAccn UnigenelD Unigene Title R1 R2 425580 L11144 Hs. 1907 galanin 33. 1 3. 5 425489 M58594 Hs. 1905 prolactin 24. 7 10. 5 430538 AB032435 Hs. 242821 differentiation-associated Na-dependent 22. 6 22. 6 417275 X63578 Hs. 295449 parvalbumin 22. 4 6. 0 428505 AL035461 Hs. 2281 chromogranin B (secretogranin 1) 21. 8 21. 8 408040 A1266496 Hs. 22905 ESTs, Weakly similar to RHG6_HUMAN RHO-G 19. 4 19. 4 435145 A1277259 Hs. 116631 ESTs 18. 5 3. 8 407039 X00368 gb : Human prolactin gene 5'region. 18. 1 18. 1 428976 AL037824 Hs. 194695 ras homolog gene family, member 1 17. 4 17. 4 409263 AA069573 Hs. 50319 ESTs 16. 8 16. 8 424645 NM_014682 Hs, 151449 KlM0535geneproduct 15. 1 15. 1 416018 AW138239 Hs. 78977 proprotein convertase sub6lisinlkexin t 14. 0 14. 0 405560 AW887701 hypothetical protein FU20628 13. 9 8. 0 452022 AW072330 Hs. 293875 ESTs 13. 8 13. 8 433940 H05129 cyclic AMP-regulated phosphoprotein, 21 12. 0 12. 0 413324 V00571 Hs. 75294 corticotropin releasing hormone 12. 0 13. 2 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 11. 5 11. 5 410330 AW023630 Hs. 159425 ESTs 11. 1 23. 4 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2. Canavan 10. 7 10. 7 420297 A1628272 Hs. 88323 ESTs, Weakly similar to ALU1HUMANALUS 10. 5 4. 1 417167 AW206437 Hs. 4290 ESTs 10. 4 10. 4 420033 D59502 Hs. 292590 ESTs 10. 4 10. 4 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 10. 0 10. 0 426380 A1291267 Hs. 149990 ESTs 9. 8 6. 9 410635 D58863 Hs. 334372 chorionic somatomammotropin hormone 1 (p 9. 5 6. 6 422756 AA441787 Hs. 119689 glycoprotein hormones, alpha polypeptide 9. 1 5. 8

444330 Api597655 Hs. 49265 ESTs 9. 1 9. 1 427322 AK002017 Hs. 176227 hyptheGcalproteinFLJ11155 8. 9 8. 9 421633 AF121860 Hs. 106260 sorting nexin 10 8. 6 6. 7 429096 AB011106 Hs. 196012 KIAA0534 protein 8. 6 8. 6 428652 AA584272 Hs. 336224 transmembrane protein with EGF-like and 8. 6 8. 6 410309 BE043077 Hs. 278153 ESTs 8. 5 8. 5 424932 R14070 Hs. 315369 Homo sapiens CDNA-FU23075 fis, clone L 8. 5 10. 2 417175 R44558 Hs. 94002 ESTs 8. 4 8. 9 427061 AB032971 Hs. 173392 KIAA1145protein 8. 4 8. 4 400438 AF185611 Hs. 115352 Target 8. 3 5. 1 418207 C14685 Hs. 34772 ESTs 8. 2 9. 8 440209 H05049 Hs. 247837 neuexin 3 8. 1 18. 7 429876 AB028977 Hs. 225974 KIAA1054 protein 8. 1 16. 8 429470 A1878901 Hs. 203862 guanine nucleotide binding protein (G pr 8. 0 8. 0 430004 U27768 Hs. 227571 regulator of G-protein signalling 4 7. 9 15. 7 436427 A1344378 Hs. 143399 ESTs 7. 8 7. 8 408814 N62499 Hs. 176227 hypothetical protein FU11155 7. 8 8. 6 434367 AB020700 Hs. 3830 KIAA0893 protein 7. 7 5. 6 441005 Z41305 Hs. 303172 Homo sapiens mRNA ; cDNA DKFZp547G133 (fr 7. 7 7. 7 416851 AW963951 Hs. 85618 ESTs 7. 7 8. 5 429033 NM 007374 Hs. 194756 sine oculis homeobox (Drosophila) homolo 7. 6 5. 5 437073 A1885608 Hs. 94122 ESTs 7. 5 7. 5 441264 AA927170 Hs. 23290 ESTs 7. 3 7. 3 450715 A1266484 Hs. 31570 ESTs, Wea'siysimilartoKIM1324pnotein 7. 2 7. 2 415076 NM 000857 Hs. 77890 guanylatecyclase1, solubb, beta3 11 4. 8 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 7. 1 10. 0 423003 AL120077 Hs. 122967 kelch (Drosophila)-like 2 (Mayven) 7. 0 7. 0 433921 AA618174 gb : nql4fO1. s1 NCl_CGAP_Thy1 Homosapiens 7. 0 7. 0 457012 R41480 Hs. 302754 ESTs 6. 9 6. 9 445898 AF070623 Hs. 13423 Homosapiensclone24468mRNAsequence 6. 9 6. 9 425352 NM 000939 Hs. 1897 proopiomelanocortin (adrenocorticotropin 6. 9 6. 1 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypothefi 6. 9 6. 9 409031 AA376836 Hs. 288856 ESTs 6. 8 6. 8 419347 C15944 Hs. 90005 superion, ervicalganglia, neuraspecifi 6. 5 22. 2 445279 R41900 Hs. 22245 ESTs 6. 4 6. 4 437414 AW894071 Hs. 48448 hypothetical protein DKFZp547C176 6. 4 6. 4 428414 AL049980 Hs. 184216 DKFZP564C152 protein 6. 4 6. 4 434104 AF116691 Hs. 116459 hypothetical protein PR02198 6. 4 4. 0 443244 A1457235 Hs. 166479 ESTs 6. 3 3. 0 447761 AF061573 Hs. 19492 protocadherin 8 6. 3 6. 3 450600 BE079478 Hs. 24880 ESTs 6. 2 3. 9 427457 AW779105 Hs. 164682 ESTs 6. 2 11. 1 416133 NM 001683 Hs. 89512 ATPase, Ca transporting, plasma membrane 6. 1 8. 0 432453 Api885537 Hs. 27172 ESTs, Moderately similar to PC4259 fern 6. 0 3. 9 432298 AL118812 Hs. 274293 HomosapiensmRNA ; cDNADKFZp761G1111 (f 6. 0 15. 1 415114 D60468 Hs. 94181 ESTs 6. 0 6. 0 416101 R24854 Hs. 268806 ESTs 5. 9 3. 3 448958 AB020651 Hs. 22653 KIAA0844 protein 5. 9 5. 9 447138 Al439112 Hs. 93828 ESTs, Weakly similar to 2109260A B cell 5. 8 5. 8 414545 AA149287 Hs. 76605 ESTs 5. 8 3. 6 424153 AA451737 Hs. 141496 MAGE-like 2 5. 7 5. 1 424641 AB001106 Hs. 151413 glia maturation factor, beta 5. 6 5. 6 410389 AW954049 Hs. 8177 ESTs, Wea'dysimilartoPIHUB6saivary 5. 6 9. 6 432149 AW614326 Hs. 133483 ESTs, Weakly similar to T34549 probable 5. 6 12. 2 408428 NM 014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 5. 6 5. 6 443912 R37257 Hs. 184780 ESTs 5. 5 6. 1 442023 A1187878 Hs. 144549 ESTs 5. 5 5. 6 450642 R39773 Hs. 7130 copine IV 5. 4 5. 6 439772 AL365406 Hs. 10268 HomosapiensmRNAfulliengthinsertcDN 5. 4 9. 8 450149 AW969781 Hs. 132863 Zic family member 2 (odd-paired Drosophi 5. 4 5. 4 438202 AW169287 Hs. 22588 ESTs 5. 3 5. 3 448605 AL109678 Hs. 21597 Homo sapiens mRNA full length insert cDN 5. 3 5. 3 418866 T65754 gb : yc11c07. s1Stratagene lung (937210) H 5. 3 3. 8 448786 BE048842 Hs. 179075 HomosapienscDNAFW11881fis, cloneHE 5. 2 5. 2 443682 A1383061 Hs. 47248 ESTs, HighlysimilartosimilartoCdc14 5. 2 3. 3 415666 H72693 gb : yuO3c11. r1Soaesétalliverspleen 5. 2 5. 2 428508 BE252383 Hs. 184668 SB8131 protein 5. 2 4. 1 446353 A1290919 Hs. 153661 ESTs 5. 1 5. 1 442106 AW205881 Hs. 326728 ESTs 5. 1 3. 2 437331 AL353933 Hs. 21710 hypothetical protein DKFZp761 G0313 5. 1 5. 1 419318 AW969742 Hs. 291005 ESTs 5. 0 3. 1 408068 AW148652 Hs. 167398 ESTs 5. 0 5. 0 434149 Z43829 Hs. 244624 hypothetical protein MGC5469 5. 0 5. 0 439238 N47305 Hs. 302161 ESTs 4. 9 5. 3 414631 AW970130 Hs. 65406 ESTs 4. 9 4. 9 447104 R19085 Hs. 210706 Homo sapiens DNA 13182fis. done NT 4. 9 3. 0 418527 AA450386 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 4. 9 4. 9 425073 W39609 Hs. 22003 solute carrier family 6 (neurotransmitte 4. 9 4. 9 433516 AA595802 Hs. 33410 ESTs, WeaklysimilartoT17279hyptheU 4. 8 4. 8 427287 NM_014903 Hs. 174188 KIAA0938 protein 4. 8 4. 8 447252 R90916 Hs. 12449 Homo sapiens transmembrane protein HTMP1 4. 8 3. 2 419643 F06066 Hs. 91791 chromosome 11 open reading frame 25 4. 7 4. 7 414949 C15314 Hs. 323349 ESTs 4. 7 3. 8

429900 AA460421 Hs. 30875 ESTs 4. 7 4. 2 422949 AA319435 gb : EST21657 Adrenal gland tumor Homo sap 4. 7 7. 4 430537 X62692 Hs. 2593 phosphodiesterase 6B, cGMP-specific, rod 4. 6 4. 6 419191 U17195 Hs. 89666 A kinase (PRKA) anchor protein 6 4. 5 4. 5 421952 AA300900 Hs. 98849 ESTs, ModeratelysimilartoAF1615111 H 4. 4 3. 2 406311 NM021979' : Homo sapiens heat shock 70kD 4. 4 11. 5 451050 AW937420 Hs. 69662 ESTs 4. 4 4. 4 423728 AW891294 Hs. 132136 solutecanierfamily4, sodiumbicarbon 4. 4 7. 9 411498 NM 014210 Hs. 70499 ecotropic viral integration site 2A 4. 3 19. 4 451301 A1769514 Hs. 209890 EST 4. 3 4. 3 452381 H23329 Hs. 290880 ESTs, Weakly similar to ALU1HUMANALUS 4. 3 4. 3 433109 N58907 Hs. 162430 EST 4. 3 3. 9 423589 AA328082 Hs. 209569 ESTs 4. 2 4. 2 427224 AL135554 Hs. 101937 sine oculis homeobox (Drosophila) homolo 4. 2 3. 9 420489 AA815089 Hs. 193513 ESTs 4. 1 4. 1 408206 AF041853 Hs. 43670 kinesin family member 3A 4. 1 4. 1 418202 N48521 Hs. 26549 KIAA1708 protein 4. 1 5. 8 448117 H49129 Hs. 172982 ESTs 4. 1 4. 1 412155 R38167 Hs. 12449 HomosapienstransmembraneproteinHTMP1 4. 0 27. 9 458694 F12832 Hs. 3610 ESTs 4. 0 4. 0 452197 AW023595 Hs. 232048 ESTs 4. 0 4. 0 408547 AA574291 Hs. 57837 ESTs 4. 0 4. 0 433447 U29195 Hs. 3281 neuronal pentraxin 11 4. 0 3. 7 448583 NM_015239 Hs. 21542 KIAA1035 protein 4. 0 4. 0 442412 R77677 Hs. 346644 ESTs 3. 9 3. 9 440293 A (004193 Hs. 22123 ESTs 3. 9 3. 9 426365 AA376667 Hs. 10283 RNA binding motif protein 8B 3. 9 4. 1 400844 NM_003105' : Homo sapiens sortiiin-reiated 3. 9 3. 1 426054 U12431 Hs. 166109 ELAV (embryonic lethal, abnormal vision, 3. 9 3. 9 429290 AF203032 Hs. 198760 neurofilamnt heavy polypeptide (200kD) 3. 8 3. 3 408777 U71204 Hs. 47626 Ric (Drosophila)-like, expressed in neur 3. 8 3. 8 442676 AI733585 Hs. 130897 ESTs 3. 8 3. 8 414699 Api815523 Hs. 76930 synuciein, alpha (non A4 component of am 3. 8 4. 5 436476 AA326108 Hs. 33829 bHLH protein DEC2 3. 8 3. 3 434998 AW975157 Hs. 26037 ESTs 3. 7 3. 7 412049 N53437 Hs. 18268 adenylate kinase 5 3. 7 10. 7 416220 N49776 Hs. 170994 hypothetical protein MGC10946 3. 7 4. 5 459697 AA406062 Hs. 98002 ESTs 3. 7 5. 4 435648 H24347 Hs. 27524 ESTs 3. 7 8. 1 442042 Ai990506 Hs. 8077 Homo sapiens mRNA ; cDNA DKFZp547E184 (tr 3. 7 6. 2 456765 A1497900 Hs. 33067 ESTs 3. 7 3. 7 434933 R91095 Hs. 4276 KIAA1701 protein 3. 6 6. 1 419518 U79289 Hs. 90798 Human clone 23695 mRNA sequence 3. 6 3. 6 452667 T87219 Hs. 13219 ESTs 3. 6 3. 6 436773 AW078629 PC4 and SFRS1 interacting protein 1 3. 6 3. 6 408119 W26213 Hs. 101672 ESTs, Weakly similar to T00333 hypotheti 3. 6 3. 6 453534 NM014796 Hs. 33187 KIAA0748 gene product 3. 6 4. 7 449093 AB035356 Hs. 22998 neuexin 1 3. 6 3. 6 442738 AW002370 Hs. 131055 ESTs, WeaklysimilartoNPM_HUMANNUCLEO 3. 5 3. 5 447746 AW015920 Hs. 161359 ESTs 3. 5 9. 9 449117 AW449310 Hs. 210262 ESTs, WeaklysimilartoHSS2_HUMANHEPAR 3. 5 3. 5 447750 A1422234 Hs. 143434 contacbn 1 3. 5 9. 8 453590 AF150278 Hs. 33578 KIAA0820 protein 3. 5 22. 3 409339 AB020686 Hs. 54037 ectonucleotide pyrophosphatase/phosphodi 3. 5 3. 6 410240 AL157424 Hs. 61289 synaptojanin 2 3. 5 4. 6 410224 M55513 Hs. 150208 potassium voltage-gated channel, shaker-3. 4 3. 4 400098 Eos Control 3. 4 3. 4 450181 H05254 Hs. 201198 ESTs 3. 4 7. 2 459080 AW192083 Hs. 290855 ESTs 3. 4 13. 5 417063 N50515 Hs. 45061 ESTs 3. 3 3. 3 424918 R13982 Hs. 169309 myelin-associated oligodendrocyte basic 3. 3 5. 3 453431 AF094754 Hs. 32973 glycine receptor, beta 3. 3 4. 6 412453 R20205 Hs. 75236 ESTs 3. 3 3. 3 450561 R49674 Hs. 25909 ESTs 3. 3 3. 3 415527 F11624 gb : HSC2ZD1 01 normalized infant brain cON 3. 3 3. 3 426968 U07616 Hs. 173034 amphiphysin (Stiff. Mann syndrome with br 3. 3 15. 3 427386 AW836261 Hs. 6727 ESTs 3. 3 3. 3 424001 W67883 Hs. 137476 paternally expressed 10 3. 2 5. 4 439450 R51613 Hs. 125304 ESTs 3. 2 8. 3 442879 AF032922 Hs. 8813 syntaxin binding protein 3 3. 2 3. 2 417284 N62889 Hs. 107242 Homo sapiens cDNA FLJ12965 fis, clone NT 3. 2 3. 2 410343 AA084273 Hs. 76561 ESTs. Weakly similar to S47072 finger pr 3. 2 3. 2 410909 AW898161 Hs. 53112 ESTs, ModeratelysimilartoALU8_HUMANA 3. 2 12. 5 453919 AW959912 Hs. 7076 KIAA1705 protein 3. 2 3. 2 424087 N69333 Hs. 143434 contain 1 3. 1 3. 1 428963 AW382682 Hs. 258208 Homo sapiens, clone MGC : 15606, mRNA, com 3. 1 3. 3 419852 AW503756 Hs. 286184 hypothe6cal protein dJ551D2. 5 3. 1 4. 1 422234 AF119818 Hs. 113287 discs, large (Drosophila) homolog-associ 3. 1 3. 1 423829 R44107 Hs. 240905 ESTs 3. 1 4. 4 443297 A1049864 Hs. 133029 ESTs 3. 1 3. 1 453302 NM000838 Hs. 32945 glutamate receptor, metabotropic 1 3. 1 4. 6 405819 NM002578 : Homo sapiens p21 (CDKN1A)-acG 3. 1 13. 5 445725 AK000956 Hs. 13209 hypotheGcal protein Fla 10094 3. 0 3. 0

447673 A1823987 Hs. 182285 ESTs 3. 0 3. 0 433670 AA604405 gb : no87hO9. si NCI CGAP M1 Homo sapiens 3. 0 3. 9 450757 BE081050 Hs. 31570 ESTs, Weakly similar to KIAA 1324 protein 3. 0 3. 2 424724 T06532 Hs. 287709 Homo sapiens cDNA : FLJ22674 fis, clone H 3. 0 3. 0 433315 R96754 Hs. 239706 GRB2-associated binding protein 1 3. 0 3. 1 451032 W03692 Hs. 323079 Homo sapiens mRNA ; cDNA DKFZp564P116 (fr 3. 0 4. 9 423346 A1267677 Hs. 127416 synaptojanin 1 3. 0 20. 1 439274 AF086092 Hs. 48372 ESTs 3. 0 18. 3 425649 U30930 Hs. 158540 UDP glycosyltransferase 8 (UDP. galactose 2. 9 38. 6 441869 NM 003947 Hs. 8004 hunGngtin-associated protein interactin 2. 9 14. 9 407868 NM000950 Hs. 40637 proline-rich Gia (G carboxyglutamic æid 2. 9 3. 3 410765 A1694972 Hs. 66180 nucleosomeasemblyprotein1-like2 2. 9 8. 0 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 2. 8 5. 9 448533 AL119710 Hs. 21365 nucleosomeassemblyprotein1-like3 2. 8 9. 6 425130 AA448208 Hs. 99163 ESTs 2. 8 3. 1 408554 AA836381 Hs. 315111 nuclear receptor co-repressor/HDAC3 comp 2. 8 3. 7 452238 F01811 Hs. 345757 ESTs 2. 8 3. 8 446544 Al631932 Hs. 7047 ESTs, Weakly similar to Unknown [H. sapie 2. 8 12. 4 433803 A1823593 Hs. 27688 ESTs 2. 8 4. 1 407728 AW071502 Hs. 175931 ESTs 2. 7 10. 2 414931 AK000342 Hs. 77646 Homo sapiens mRNA ; cDNADKFZp761M0223 (f 2. 7 3. 4 410711 AB002316 Hs. 65746 KIAA0318 protein 2. 7 6. 1 452738 AL133800 Hs. 7086 hypotheGcalprotein MGC12435 2. 7 3. 5 451516 A1800515 Hs. 12024 ESTs 2. 7 6. 3 454053 AW023006 Hs. 27172 ESTs, Moderately similar to PC4259 ferri 2. 7 3. 6 450474 AW872844 Hs. 117494 ESTs 2. 7 7. 2 422414 AW875237 Hs. 13701 ESTs 2. 7 5. 3 428186 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 2. 7 3. 9 431342 AW971018 Hs. 21659 ESTs 2. 7 8. 0 423449 A1497900 Hs. 33067 ESTs 2. 6 14. 5 427283 AL119796 Hs. 174185 ectonucleotide pyrophosphataselphosphodi 2. 6 3. 0 426919 AL041228 ELAV (embryonic lethal, abnormal vision, 2. 6 9. 0 437117 AL049256 Hs. 122593 ESTs 2. 6 3. 8 422491 AA338548 Hs. 117546 neuronatin 2. 6 3. 6 438068 AI927209 Hs. 306210 Homo sapiens CDNA-FLJ23133 fis, clone L 2. 6 5. 1 432809 AA565509 Hs. 131703 ESTs 2. 5 9. 9 433551 A1985544 Hs. 12450 protocadherin 9 2. 5 18. 1 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 2. 5 43. 2 417417 F05745 Hs. 89512 ATPase, Ca transporting, plasma membrane 2. 5 17. 1 413554 AA319146 Hs. 75426 secetogranin 11 (chromogranin C) 2. 5 5. 7 448902 Z45998 Hs. 22543 HomosapiensmRNA ; cDNADKFZp76111912 (f 2. 5 21. 8 442910 Al365130 Hs. 11307 ESTs, Weakly similar to T19326 hypotheti 2. 5 14. 5 423135 N67655 Hs. 26411 ESTs 2. 5 8. 2 452311 AW304029 Hs. 252744 ESTs 2. 5 3. 5 418940 H17739 Hs. 288513 Human DNA sequence from clone RPS-899C14 2. 5 7. 0 432882 NM 013257 Hs. 279696 serum/gtucocorticoid regulated kinase-li 2. 5 4. 2 422411 AW749443 Hs. 22511 ESTs 2. 5 12. 0 451386 AB029006 Hs. 26334 spastic paraplegia 4 (autosomal dominant 2. 4 3. 1 404819 NM002688' : Homo sapiens peanut (Drosophi 2. 4 5. 8 429656 X05608 Hs. 211584 neurofilament lightpolypeptide (68kD) 2. 4 13. 1 431988 AC002302 Hs. 77202 protein kinase C, beta 1 2. 4 10. 5 411379 AI816344 Hs. 12554 ESTs. WeaklysimilartoNPL4_HUMANNUCLE 2. 4 11. 2 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (CIEBP). 2. 4 45. 2 429859. NM 007050 Hs. 225952 protein tyrosine phosphatase, receptor t 2. 4 5. 1 430287 AW182459 Hs. 125759 ESTs, WeaklysimilartoLEU5_HUMANLEUKE 2. 4 7. 6 422890 Z43784 ankyr 3, node of Ranvier (ankyrin G) 2. 4 3. 6 427658 H61387 Hs. 30868 nogo receptor 2. 4 3. 0 446100 AW967109 Hs. 13804 hypotheticat protein dJ462023. 2 2. 3 3. 6 412266 N59006 Hs. 26133 ESTs 2. 3 30. 9 435059 Z45270 Hs. 235873 hypothetical protein FU22672 2. 3 4. 8 420173 AA256151 Hs. 22999 ESTs 2. 3 4. 1 452371 R40990 Hs. 21658 ESTs 2. 3 3. 3 430456 AA314998 Hs. 241503 hypothetical protein 2. 3 4. 7 409953 AA332277 Hs. 57691 cadherin 18, type 2 2. 3 5. 5 429006 AA443143 Hs. 50929 hyptheUca protein FW13842 2. 3 6. 6 445194 A1215667 Hs. 175044 ESTs 2. 3 3. 1 428392 H10233 Hs. 2265 secretory granule, neuroendocnne protei 2. 3 42. 3 434460 AA478486 Hs. 3852 KIAA0368 protein 2. 3 4. 8 416490 AF090116 Hs. 79348 regulatorofG-proteinsignalling7 2. 3 12. 5 437924 Api935344 Hs. 164118 ESTs, Weakly similar to SL51 HUMAN SODIU 2. 3 3. 2 418738 AW388633 Hs. 6682 solute carrier family 7, (cationic amino 2. 2 16. 9 424945 Al221919 hypotheUcal protein FW10582 2. 2 30. 5 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) 2. 2 4. 4 422927 AW247388 Hs. 301423 calcium binding protein 1 (calbrain) 2. 2 3. 0 438831 BE263273 Hs. 6439 synapsin 11 2. 2 3. 4 449078 AK001256 Hs. 22975 KIAA1576 protein 2. 2 16. 1 410631 AA086469 Hs. 47171 ESTs 2. 2 5. 8 419271 N34901 Hs. 238532 ESTs 2. 2 7. 5 452752 AW044058 Hs. 33578 KIAA0820 protein 2. 2 13. 4 446574 A1310135 Hs. 335933 ESTs 2. 2 3. 5 452106 Al141031 Hs. 21342 ESTs 2. 2 3. 4 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor1 2. 2 28. 9 444458 BE041526 Hs. 31746 hypothetical protein DKFZp547F072 2. 2 7. 7

446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 2. 2 33. 0 412788 AA120960 Hs. 198416 ESTs 2. 2 8. 5 419103 Z40229 Hs. 96423 hypothetical protein FLJ23033 2. 2 8. 4 424474 AA308883 Hs. 148680 calcyon ; D1 dopamine receptor-interacEn 2. 2 3. 6 451783 R42554 Hs. 210862 T-box, brain, 1 2. 1 11. 2 434792 AA649253 Hs. 132458 ESTs 2. 1 3. 8 424922 BE386547 Hs. 217112 hypothetical protein MGC10825 2. 1 3. 7 455364 H72176 Hs. 4273 hypothetical protein FU13159 2. 1 4. 9 413988 M81883 Hs. 324784 glutamate decarboxylase 1 (brain, 67kD) 2. 1 5. 1 452744 A1267652 Hs. 246107 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 2. 1 3. 6 443150 A1034467 Hs. 34650 ESTs 2. 1 7. 6 453220 A8033089 Hs. 32452 HomosapiensmRNAforKIM1263pnotein 2. 1 19. 9 420050 AL118615 Hs. 94653 neurochondrin 2. 1 6. 5 408449 NM 004408 Hs. 166161 dynamin 1 2. 1 5. 1 423641 AL137256 Hs. 130489 ATPase, aminophospholipidtransprter-li 2. 1 6. 2 430347 NM2039 Hs. 239706 GRB2-associated binding protein 1 2. 1 3. 2 449568 AL157479 Hs. 23740 KIAA1598 protein 2. 1 3. 6 412675 AA460716 Hs. 9788 hyptheGcalproteinMGC10924similarto 21 3. 3 429550 AW293055 Hs. 119357 ESTs 2. 1 6. 4 446782 A1653048 Hs. 144006 ESTs 2. 1 9. 0 453924 R49295 Hs. 24886 ESTs 2. 1 13. 4 437948 AA772920 Hs. 303527 ESTs 2. 1 24. 8 451952 AL120173 Hs. 301663 ESTs 2. 0 19. 2 453754 AW972580 Hs. 172753 ESTs 2. 0 3. 4 448765 R15337 Hs. 21958 Homo sapiens mRNA ; cDNA DKFZp547D086 (fr 2. 0 3. 9 447163 AW292770 Hs. 5542 DnaJ (Hsp40) homolog, subfamily C, membe 2. 0 3. 4 448299 AA497044 Hs. 20887 hypothetical protein FLJ10392 2. 0 11. 5 411666 AF106564 Hs. 71346 neurofilament 3 150kD medium) 2. 0 6. 6 424458 M29273 Hs. 1780 myelin associated glycoprotein 2. 0 10. 1 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 2. 0 28. 5 440152 AB002376 Hs. 7006 KIAA0378 protein 2. 0 14. 2 429956 AI374651 Hs. 22542 ESTs 2. 0 3. 2 450590 A1701507 Hs. 273740 ESTs 2. 0 3. 8 429024 AI652297 Hs. 119302 complement-lq tumor necrosis factor-rel 2. 0 3. 7 430643 AW970065 Hs. 287425 MEGF10 protein 2. 0 4. 1 415734 NM014747 Hs. 78748 KIAA0237 gene product 2. 0 27. 4 419757 AA773820 Hs. 63970 ESTs 2. 0 3. 3 421264 AL039123 Hs. 103042 microtubule-associated protein 1B 2. 0 23. 8 439607 BE540565 Hs. 159460 ESTs 2. 0 5. 6 435624 AF218942 Hs. 24889 formin 2 2. 0 12. 2 425121 A1797511 Hs. 154679 synaptotagminl 2. 0 3. 9 431677 AK000496 Hs. 306989 hypothetical protein FLJ20489 2. 0 3. 1 442593 R39804 Hs. 31961 ESTs 2. 0 6. 7 410366 A1267589 Hs. 302689 hypothetical protein 2. 0 10. 4 426575 M74826 Hs. 170808 glutamate decarboxylase 2 (pancreatic is 2. 0 4. 6 452856 AF034799 Hs. 30881 protein tyrosine phosphatase, receptor t 2. 0 10. 7 437380 AL359577 Hs. 112198 Homo sapiens mRNA ; cDNA DKFZp547M073 (fr 2. 0 3. 8 424893 AW295112 Hs. 153648 Homo sapiens CDNA FU 13303 fis, clone OV 2. 0 3. 8 436734 A1937612 Hs. 273758 hypotheticalprotein FU23112 2. 0 4. 7 422544 AB018259 Hs. 118140 KIAA0716 gene product 2. 0 11. 8 440105 AA694010 Hs. 6932 Homo sapiens clone 23809 mRNA sequence 2. 0 8. 2 425741 AF052152 Hs. 159412 Homo sapiens clone 24628 mRNA sequence 2. 0 6. 5 450310 N62341 Hs. 94116 ESTs 2. 0 3. 6 TABLE 20B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 415527 1539393 1 F11624 Z43212 H08936 R56332 H09256 R52303 R13075 415666 1543492 1 H72693 R08673 H72694 F20990 R08580 418866 179788 1 T65754 AA229857 AA229658 422890 222707 1 Z43784 R13382 AW572911 AA449369 H17037 R19603 A1632565 AW004030 BE502530 Z25032 AA805324 AA449241 Al651825 Al264863 AW196918 T87230A) 3 AA948267 AI953735 AI263703 AA319159 AW964436 AI903440 AW594171 AI867447 AW204071 AW956110 C15616 D81142 H17038 AW162343 T87230 Al3 422949 223184_1 AA319435 N56456 AA319377 AW961532 T48452 AA894424 424945 245223 1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 A1341345 AW298800 AA724961 AA931158 Api741227 AI806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 A1492961 AI361526 F04002 AA452141 T23551 Al472655 A1193667 A1341 426919 2735071 AL041228 D82004 D61361 Al203314 Al990307 AW900295 A1018308 AW087473 AW183530 AA393346 H50055 AA935601 433670 372721 1 M604405 BE062234 AW748386 433921 377350J AA618174Ai114549R36464R36465 433940 37787_1 H05129 N63433 A1651350 AA984734 A1368716 N409t5 A1989705 F09042 T03905 R88588 AF112220 436773 426857_1 AW078629 A1857375 N64357 AA731069 446692 689623_1 Z44514 A1352097 A1803984 AW235923 AWI 96558 A1954637 A1336983 TABLE 20C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (Gl) numbers. Dunham et refers to the publication entitled'The DNA sequence of human chromosome 2Z Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleo6de positions of predicted exons.

Pkey Ref Strand Nt posi6on 400844 9188605 Plus 24746-24872, 25035-25204 404819 4678240 Plus 16223163t9, 16427-16513, 1636-16859, 16941-17075. 17170. 17287, 173817529, 18261-18357, 18443-18578 405560 183148 Plus 54955655. 6077-6241, 6495-6692 405819 4007557 Plus 2830-2967 406311 9211559 Minus 137114-139033 TABLE 21A : ABOUT 410 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL ADULT CNS Table 21A lists about 410 genes significantly down-regulated in glioblastoma multiforma (GBM) compared to normal adult CNS tissues. These were sefected from 59680 probesets on the Ah'ymetn'xlEos Hu03 GeneChip array such that the ratio of'average* normal CNS to'average GBM was greater than or equal to 2. The'average'normal CNS level was set to the 75 pen enGle amongst various normal CNS tissues. The'average'GBM level was set to the 95'^ percenGle amongst various tumor samples. In order to remove gene-specific background levels of non-specific hybridization, the 1 0t percenUle value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene TiGe : Unigene gene Ode R1 : Ratio of CNS to GLIOBLASTOMA MULTIFORMA Pkey ExAccn UnigenelD Unigene Title R1 417275 X63578 Hs. 295449 parvalbumin 18. 6 428505 AL035461 Hs. 2281 chnomogranin B (secretogranin 1) 13. 8 415672 N53097 Hs. 193579 ESTs 13. 5 459080 AW192083 Hs. 290855 ESTs 12. 9 432298 AL118812 Hs. 274293 HomosapiensmRNA ; cDNADKFZp761G1111 (f 11. 7 400302 N48056 Hs. 1915 folate hydrolase (prostate-specific memb 10. 9 418318 U47732 Hs. 84072 transmembrane 4 superfamily member 3 10. 1 424645 NM_014682 Hs. 151449 KIAA0535 gene product 8. 2 415274 AF001548 Hs. 78344 myosin, heavy polypeptide 11, smooth mus 7. 5 413324 V00571 Hs. 75294 corticotropin releasing hormone 7. 5 417167 AW206437 Hs. 4290 ESTs 7. 3 422728 AW937826 Hs. 103262 ESTs, Weaxly similar to ZN91 _HUMAN ZINC 6. 8 410330 AW023630 Hs. 159425 ESTs 6. 5 450590 A1701507 Hs. 273740 ESTs 6. 5 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 6. 5 454076 AW204712 Hs. 61957 ESTs 6. 3 419956 AL137939 Hs. 40096 ESTs 6. 3 416851 AW963951 Hs. 85618 ESTs 6. 2 428874 W32133 Hs. 194366 transthyreGn (prealbumin, amyloidosis t 6. 0 409743 N48721 Hs. 183506 hypothetical protein FLJ14213 5. 9 449078 AK001256 Hs. 22975 KIAA1576 protein 5. 6 448072 A1459306 Hs. 24908 ESTs 5. 6 412622 AW664708 Hs. 171959 ESTs 5. 6 428414 AL049980 Hs. 184216 DKFZP564C152 protein 5. 5 427322 AK002017 Hs. 176227 hypothetical protein FLJ 11155 5. 5 411498 NM014210 Hs. 70499 ecotropic viral integration site 2A 5. 4 453344 BE349075 Hs. 44571 ESTs 5. 4 441790 AW294909 Hs. 132208 ESTs 5. 3 443037 AW500305 Hs. 8906 syntaxin 7 5. 3 445529 H14421 Hs. 180513 ATP-binding cassette, sub-family A (ABC1 5. 2 447750 A1422234 Hs. 143434 contactin 1 5. 2 444409 A1792140 Hs. 49265 ESTs 5. 2 409031 AA376836 Hs. 288856 ESTs 5. 1 453220 AB033089 Hs. 32452 Homo sapiens mRNA for KIAA1263 protein, 5. 0 452022 AW072330 Hs. 293875 ESTs 4. 9 408428 NM014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 4. 8 444922 A1921750 Hs. 144871 Homo sapiens cDNA FLJ13752 fis, clone PL 4. 8 443622 A1911527 Hs. 11805 ESTs 4. 8 442023 Al187878 Hs. 144549 ESTs 4. 7 445618 H79667 Hs. 237642 Homo sapiens cDNA FW 12052 fis, done HE 4. 6 429611 A1889077 Hs. 211388 Homo sapiens BAC clone CTB-60N22 from 7q 4. 5 414290 A1568801 Hs. 71721 ESTs 4. 4 450715 A1266484 Hs. 31570 ESTs, Weakly similarto KIAA1324 protein 4. 4 428508 BE252383 Hs. 184668 S88131 protein 4. 4 425649 U30930 Hs. 158540 UDP glycosyltransterase 8 (UOP-galactose 4. 3 459247 N46243 Hs. 110373 ESTs, Highly similar to T42626 secreted 4. 3 434064 AL049045 Hs. 180758 hypothetical protein PR00082 4. 3 414602 AW630088 Hs. 76550 HomosapiensmRNA cONADKFZpS64B1264 (f 4. 3 416133 NM_001683 Hs. 89512 ATPase. Ca transportng, plasma membrane 4. 3 426471 M22440 Hs. 170009 transforming growth factor, alpha 4. 2 409231 AA446644 Hs. 692 GA733-2 antigen ; epithelial glycoprotein 4. 2 448958 AB020651 Hs. 22653 KIAA0844 protein 4. 2 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 4. 1 447138 Al439112 Hs. 93828 ESTs, Weakly similar to 2109260A B cell 4. 1 440736 D56919 Hs. 265848 myomegalin 4. 1 407245 X90568 Hs. 172004 Gitin 4. 1 441976 AA428403 Hs. 106131 ESTs 4. 1 450642 R39773 Hs. 7130 copine IV 41 432799 NM_016161 Hs. 278960 alpha-1, 4-N-acetylglucosaminyltransferas 4. 0 428465 AW970976 Hs. 293653 ESTs 4. 0 407868 NM_000950 Hs. 40637 proline-rich Gla (G-carboxyglutamic acid 4. 0

433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheti 4. 0 429470 A1878901 Hs. 203862 guanine nucleoGde binding protein (G pr 4. 0 415666 H72693 gb : yu03c11. riSoaresfetalliverspleen 3. 9 407988 N47760 Hs. 285107 hypothetical protein FLJ13397 3. 9 427061 AB032971 Hs. 173392 KlM1145protein 3. 9 430261 AA305127 Hs. 237225 hypothetical protein HT023 3. 9 440624 AF017987 Hs. 7306 secreted fizzled-related protein 1 3. 8 431668 AW969610 Hs. 151179 ESTs 3. 8 446692 Z44514 Homo sapiens mRNA for KIAAI 763 protein, 3. 8 408739 W01556 Hs. 238797 ESTs, Moderately similar to 138022 hypot 3. 8 426716 NM006379 Hs. 171921 sema domain, immunoglobulin domain (1g), 3. 8 450103 R08665 Hs. 17244 hypothetical protein FLJ13605 3. 7 426775 AA384564 Hs. 3628 ESTs 3. 7 403469 Target Exon 3. 7 450181 H05254 Hs. 201198 ESTs 3. 7 438202 AW169287 Hs. 22588 ESTs 3. 7 445279 R41900 Hs. 22245 ESTs 3. 7 422546 AB007969 Hs. 301478 KIAA0500 protein 3. 7 435712 AA694607 Hs. 176956 ESTs 3. 6 417620 R02530 Hs. 191198 ESTs 3. 6 421952 AA300900 Hs. 98849 ESTs, ModerateiysimilartoAF1615111 H 3. 6 453655 AW960427 Hs. 342874 transforming growth factor, beta recepto 3. 6 426365 AA376667 Hs. 10283 RNA binding motif protein 8B 3. 6 416982 J05401 Hs. 80691 creatine kinase, mitochondrial 2 (sarcom 3. 6 438086 AA336519 Hs. 83623 nuclear receptor subfamily 1, group I, m 3. 6 424704 At263293 Hs. 152096 cytochrome P450, subfamily IIJ (arachido 3. 6 414631 AW970130 Hs. 65406 ESTs 3. 6 453698 AA037615 Hs. 42746 ESTs 3. 6 438704 A1435060 Hs. 32825 ESTs 3. 5 437073 A1885608 Hs. 94122 ESTs 3. 5 434460 AA478486 Hs. 3852 KIAA0368 protein 3. 5 414541 BE293116 Hs. 76392 aldehyde dehydrogenase 1 family, member 3. 5 423665 BE167153 Hs. 24380 ESTs 3. 5 446390 AA233393 Hs. 14992 hypothetical protein FLJ 11151 3. 5 441264 AA927170 Hs. 23290 ESTs 3. 5 433629 R13140 Hs. 13359 ESTs 3. 5 411811 AW864370 gb : PM4-SN0016-100500-004-hO9SN0016Homo 3. 5 410140 AL134435 Hs. 247837 neurexin 3 3. 4 415114 D60468 Hs. 94181 ESTs 3. 4 455649 BE065051 gb : RC1-BT0313-110500-017-cO4BT0313Homo 3. 4 433670 AA604405 gb : no87hO9. sl NCI_CGAP_M1 Homo sapiens 3. 4 417175 R44558 Hs. 94002 ESTs 3. 4 427176 AW381569 Hs. 40334 ESTs 3. 4 448519 AW175665 Hs. 278695 Homo sapiens prostein mRNA, complete cds 3. 4 457012 R41480 Hs. 302754 ESTs 3. 3 405354 CX000321 : gil66715791refINP-031518. 11 ad 3. 3 445872 A1681573 Hs. 288671 Homo sapiens CDNA FU 11997 fis, clone HE 3. 3 433803 A1823593 Hs. 27688 ESTs 3. 3 449017 AW002425 Hs. 224142 ESTs 3. 3 414545 AA149287 Hs. 76605 ESTs 3. 3 409010 Al648675 Hs. 103441 Homo sapiens, Similar to RIKEN CDNA 1700 3. 3 426158 NM001982 Hs. 199067 v-erb-b2 avian erythroblastic leukemia v 3. 3 422411 AW749443 Hs. 22511 ESTs 3. 3 428850 AA934975 Hs. 185076 ESTs 3. 3 406922 S70284 Hs. 119597 gb : stearoyl-CoAdesaturase [human, adipo 3. 2 429556 AW139399 Hs. 98988 ESTs 3. 2 434104 AF116691 Hs. 116459 hypothetical protein PR02198 3. 2 427229 A1799751 Hs. 5635 ESTs 3. 2 444458 BE041526 Hs. 31746 hypothetical protein DKFZp547F072 3. 2 433328 AW298159 Hs. 23644 ESTs, Weakly similar to S65824 reverse t 3. 2 412786 AW900654 Hs. 285729 ESTs, Weakly similar to unnamed protein 3. 2 440808 AK001339 Hs. 7432 hypothetical protein FU10477 3. 2 442117 AW664964 Hs. 128899 ESTs : hypothetical protein for IMAGE : 447 3. 1 429876 AB028977 Hs. 225974 KIAA1054 protein 3. 1 450757 BE081050 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 3. 1 414327 BE408145 Hs. 185254 ESTs, Weakly similar to T24435 hypotheG 3. 1 459399 BE407712 Hs. 153998 creatine kinase, mitochondrial 1 (ubiqui 3. 1 433582 BE548749 Hs. 148016 ESTs 3. 1 452752 AW044058 Hs. 33578 KIAA0820 protein 3. 0 439165 AA029517 Hs. 95162 KCNQ1 overlapping transcript 1 3. 0 409403 AA668224 Hs. 6634 Homo sapiens cDNA : FLJ22547 fis, clone H 3. 0 422414 AW875237 Hs. 13701 ESTs 3. 0 407173 T64349 gb : yc10d08. s1 Stratagene lung (937210) H 3. 0 448583 NM 015239 Hs. 21542 KlM1035protein 30 429043 A1824977 Hs. 145319 ESTs 3. 0 452990 AA887428 Hs. 246970 mitogen-activated protein kinase kinase 3. 0 412258 AA376768 Hs. 324841 hypothetical protein FW22622 3. 0 429968 AA322503 Hs. 227011 G-substrate 3. 0 434348 BE393191 Hs. 181795 putaGveb, b-carotene-9', 10'-dioxygenase 2. 9 427115 AW972853 Hs. 112237 ESTs 2. 9 430538 AB032435 Hs. 242821 differentiation-associated Na-dependent 2. 9 449561 A1022240 Hs. 17924 ESTs, Moderately similar to ALUL-HUMAN A 2. 9 405403 Target Exon 2. 9

452197 AW023595 Hs. 232048 ESTs 2. 9 437357 AL359559 Hs. 331666 Homo sapiens mRNA ; cDNA DKFZp76202215 (f 2. 9 436427 A1344378 Hs. 143399 ESTs 2. 9 417787 R14948 Hs. 23883 ESTs 2. 9 439272 AA832474 Hs. 25851 ESTs 2. 9 454247 AJ243950 Hs. 46735 deafness locus associated putative guani 2. 9 415839 R40611 Hs. 94694 ESTs 2. 9 408814 N62499 Hs. 176227 hypotheGcalproteinFW11155 2. 9 408468 A1909712 Hs. 93837 phosphatidytinositot transfer protein, m 2. 9 431304 BE157283 gb : RC4-HT0373-130200-011-aO3HT0373Homo 2. 9 410240 AL157424 Hs. 61289 synaptojanin 2 2. 9 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 2. 8 408438 AB011180 Hs. 100960 KIAA0608 protein 2. 8 458793 N80159 Hs. 121849 microtubule-associated proteins 1A/18ti 2. 8 429788 U87791 Hs. 221040 HBS1 (S. cerevisiae)-like 2. 8 424264 D80400 Hs. 239388 HumanDNAsequencefromcloneRP1-304B14 2. 8 433109 N58907 Hs. 162430 EST 2. 8 427974 BE093023 Hs. 188767 ESTs 2. 8 432266 AK000385 Hs. 274222 hypothetical protein FU20378 2. 8 414764 AW013887 Hs. 31522 ESTs 2. 8 411918 AW876354 gb : PM4-PT0019-141299-009-F08PT0019Homo 2. 8 404563 Target Exon 2. 8 446468 AI765890 Hs. 16341 MAWD binding protein 2. 8 444755 AA431791 Hs. 113823 OpX (caeinolyGcproteaeX, E. coli) 2. 8 445898 AF070623 Hs. 13423 Homo sapiens clone 24468 mRNA sequence 2. 7 427263 AL119796 Hs. 174185 ectonucleo6depyrophosphatase/phosphodi 2. 7 400138 Eos Control 2. 7 458676 A1692464 Hs. 202263 ESTs 2. 7 459697 AA406062 Hs. 98002 ESTs 2. 7 444420 A1148157 Hs. 146766 ESTs 2. 7 430371 D87466 Hs. 240112 KIAA0276 protein 2. 7 449117 AW449310 Hs. 210262 ESTs, WeaklysimilartoHSS2 HUMANHEPAR 2. 7 424994 AW954525 gb : EST366595 MAGE resequences, MAGC Homo 2. 7 400339 X57131 Hs. 248209 H2A histone family, member F, pseudogene 2. 7 417494 A1369494 Hs. 222137 ESTs 2. 7 427166 AA431576 Hs. 99154 ESTs 2. 7 404746 CX000138' : gi7512767pirIIT12477 hypothe 2. 7 411361 AW839073 gb : CM2-LT0066-030100-109-dO6 LT0066 Homo 2. 7 428358 AA993222 Hs. 101915 Stargardtdiseae3 (autosomadominant) 2. 7 406625 Y13647 Hs. 119597 stearoyl-CoAdesaturase (delta-9-desatur 2. 7 416101 R24854 Hs. 268806 ESTs 2. 7 404606 Target Exon 2. 7 433921 AA618174 gb : nql4fO1. sl NCl_CGAP_Thyl Homo sapiens 2. 7 414272 A1651603 Hs. 46988 ESTs 2. 7 418047 R37633 Hs. 4847 ESTs 2. 7 421089 AB037771 Hs. 101799 KIAA1350 protein 2. 7 412244 AW948175 gb : RCO-MT0013-280300-021-c10 MT0013 Homo 2. 7 432434 AL161977 Hs. 2994 PCTAIRE protein kinase 3 2. 6 424153 AA451737 Hs. 141496 MAGE-like 2 2. 6 427189 H82453 Hs. 5635 ESTs 2. 6 454454 AW612264 Hs. 131705 ESTs 2. 6 426747 AA535210 Hs. 171995 kallikrein 3, (prostate specific antigen 2. 6 456791 H05202 Hs. 133968 FGF receptor activating protein 1 2. 6 405715 ENSP00000005198' : Mixed lineage kinase ML 2. 6 425494 N55540 Hs. 78026 ESTs, Weakly similar to similar to ankyr 2. 6 430865 A1073424 Hs. 5232 HSPC125 protein 2. 6 435767 H73505 Hs. 117874 ESTs 2. 6 410119 F07841 Hs. 13926 ESTs 2. 6 432146 AW081072 Hs. 115960 K) AA0939 protein 2. 6 448871 BE616709 Hs. 159265 kruppel-related zinc finger protein hcKr 2. 6 414516 Api307802 Hs. 135560 ESTs, Weakly similar to T43458 hypotheti 2. 6 429477 Al275514 Hs. 6658 ESTs 2. 6 400269 Eos Control 2. 5 443992 AW022228 Hs. 322922 ESTs 2. 5 451926 AW134519 Hs. 96125 Homosapiens, SimilartocloneFLB3816, 2. 5 435145 A1277259 Hs. 116631 ESTs 2. 5 420309 AW043637 Hs. 21766 ESTs, Weakly similar to ALU5_HUMAN ALU S 2. 5 449709 BE410592 Hs. 23918 hypothetical protein PP5395 2. 5 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) 2. 5 411678 A1907114 Hs. 71465 squaleneepoxidase 2. 5 408119 W26213 Hs. 101672 ESTs, WeaklysimilartoT00331 hypotheG 2. 5 436624 T64297 fatty acid binding protein 1, liver 2. 5 458268 AA428403 Hs. 106131 ESTs 2. 5 451336 A1264643 Hs. 3610 ESTs 2. 5 456924 Al631510 Hs. 196956 ESTs, Highly similar to match to EST M3 2. 5 455040 AW852286 gb : QVO-CT0225-100400-187-d08 CT0225 Homo 2. 5 420033 D59502 Hs. 292590 ESTs 2. 5 448786 BE048842 Hs. 179075 Homo sapiens CDNA FU 11881 fis, clone HE 2. 5 432251 AW972983 Hs. 232165 polycythemia rubra vera 1 ; cell surface 2. 5 408206 AF041853 Hs. 43670 kinesin family member 3A 2. 5 440205 T86950 Hs. 105448 ESTs, Weakly similar to B34087 hypotheti 2. 5 442138 AA445973 Hs. 13303 Homo sapiens cDNA : FLJ21784 fis, clone H 2. 5 420912 AW853156 Hs. 90787 ESTs 2. 4

439180 Api393742 Hs. 199067 v-erb-b2avianerythroblaGcleukemiav 2. 4 421025 AW958975 Hs. 29397 Homo sapiens cDNA FU13226 fis, clone OV 2. 4 439973 A1733308 Hs. 124663 ESTs 2. 4 446847 T51454 Hs. 82845 Homo sapiens cDNA : FLJ21930 fis, clone H 2. 4 414672 Api218038 Hs. 48504 ESTs, Moderately similar to ALU5_HUMAN A 2. 4 451522 BE565817 Hs. 26498 hypothe6cal protein FU21657 2. 4 433068 NM 006456 Hs. 288215 siayltransferae 2. 4 446620 AA128808 Hs. 179902 transporter-like protein 2. 4 423803 NM_005709 Hs. 132945 PDZ-73 protein 2. 4 407978 AW385129 Hs. 41717 phosphodiesterase 1A, calmodulin-depende 2. 4 425907 AA365752 Hs. 155965 ESTs 2. 4 433819 AW511097 Hs. 112765 ESTs 2. 4 446066 A1343931 Hs. 149383 ESTs 2. 4 430573 AA744550 Hs. 136345 ESTs 2. 4 444992 R37658 Hs. 21375 ESTs 2. 4 434975 AA657884 Hs. 314413 ESTs 2. 4 458227 Z40670 Hs. 181340 ESTs 2. 4 443244 A1457235 Hs. 166479 ESTs 2. 4 432408 N39127 ESTs, Weakly similar to A46010 X-linked 2. 4 401600 BE247275 U5 snRNP-specific protein, 116 kD 2. 3 419066 Z98492 Hs. 6975 PR01073protein 2. 3 424823 NM_006226 Hs. 153322 phospholipase C, epsilon 2. 3 402124 NM_031891 : Homo sapiens cadherin 20, type 2. 3 416678 N80448 Hs. 269106 ESTs 2. 3 444897 AW137088 Hs. 144857 ESTs Z3 425111 BE018485 Hs. 30977 ESTs, Weakly similar to B34087 hypothe 2. 3 400536 NM000681* : Homo sapiens adrenergic, alph 2. 3 427544 A1767152 Hs. 181400 ESTs, Weakly similar to 178885 sednefth 2. 3 459511 Al142379 gb : qg64cO1. r1 Soares_tesGs_NHT Homo sap 2. 3 415111 R39039 Hs. 279041 EST 2. 3 433331 A1738815 Hs. 117323 ESTs 2. 3 440293 A1004193 Hs. 22123 ESTs 2. 3 411770 NM 014278 Hs. 71992 heatshockprotein (hsp110family) 2. 3 416964 D87467 Hs. 80620 guanine nucleotide exchange factor for R 2. 3 419386 AA236867 ESTs, Weakly similar to 138022 hypotheG 2. 3 402493 A1743260 mannosidase, alpha, class 1A, member 1 2, 3 401783 NM 003771 : Homo sapiens keratin, hair, a 2. 3 420548 AA278246 Hs. 920 ESTs 2. 3 419763 A1039691 Hs. 127486 ESTs 2. 3 421750 AK000768 Hs. 107872 hypothetical protein FU20761 2. 3 406023. Target Exon 2. 3 454024 AA993527 Hs. 293907 hypothetical protein FU23403 2. 3 401586 Target Exon 2. 3 404091 Target Exon 2. 3 456773 A1038192 Hs. 129764 EGF-like repeats and discoidin I-like do 2. 3 414106 BE300325 Hs. 77135 RNA binding protein 2. 3 454288 BE222648 Hs. 241432 ESTs, Highly similar to c380A1. 1b [H. sap 2. 3 441879 Api521936 Hs. 107149 novel protein similar to archaeal, yeast 2. 3 424724 T06532 Hs. 287709 Homo sapiens cDNA : FU22674 fis, clone H 2. 3 415692 N51935 Hs. 47374 Homo sapiens cDNA FW13561 fis, clone PL 2. 3 416282 R86664 Hs. 167257 brain link protein-1 2. 2 404659 ENSP00000239999' : HYPOTHETICAL 34. 7 kDa P 2. 2 429956 A1374651 Hs. 22542 ESTs 2. 2 429670 L01087 Hs. 211593 protein kinase C, theta 2. 2 429655 U48959 Hs. 211582 myosin, light polypepbde kinase 2. 2 458921 Api682088 Hs. 79375 holocarboxylase synthetase (bio6in- [prop 2. 2 436463 H06502 Hs. 6656 ESTs 2. 2 408994 AW299520 Hs. 43052 ESTs 2. 2 413303 AW836130 Hs. 75277 hypotheUca'protein FW13910 2. 2 418154 BE165866 nuclear receptor subfamily 1, group 1, m 2. 2 418407 AL044818 Hs. 84928 nuclear transcription factor Y, beta 2. 2 422907 A1879263 Hs. 77273 Human glucose transporter pseudogene 2. 2 446377 AW014022 Hs. 170953 ESTs 2. 2 429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 2. 2 449714 AB033015 Hs. 23941 KIAA1189 protein 2. 2 408480 A1350337 Hs. 164568 fibrobiast growth factor 7 (keratinocyte 2. 2 410066 AL117664 Hs. 58419 DKFZP586L2024 protein 2. 2 410912 AW810224 gb : MR4-ST0125-021199-017-eO7ST0125Homo 2. 2 447163 AW292770 Hs. 5542 DnaJ (Hsp40) homotog, subfamily C, membe 2. 2 421709 AA159394 Hs. 107056 CED-6 protein 2. 2 403728 Target Exon 2. 2 453359 AA448787 Hs. 24872 ESTs 2. 2 411379 Api816344 Hs. 12554 ESTs, WeaklysimilartoNPL4 HUMANNUCLE 2. 2 413427 U31120 Hs. 845 intedeukin 13 2. 2 409028 AB014513 Hs. 49998 Z-band alternatively spliced PDZ-motif 2. 2 413924 AL119964 Hs. 75616 seladin-1 2. 2 403463 Target Exon 2. 2 408068 AW148652 Hs. 167398 ESTs 2. 2 407819 R42185 Hs. 102720 ESTs 2. 2 414203 BE262170 Hs. 78629 ATPase, Na ? transporting, beta 1 polypep 2. 2 448045 AJ297436 Hs. 20166 prostate stem cell anGgen 2. 2 449835 AW979300 Hs. 293813 ESTs 2. 2 458547 AW204314 Hs. 170784 ESTs 2. 2

414276 BE297862 gb : 601174780FlNIH_MGC_17Homosapiensc 2. 2 427493 H09037 Target CAT 2. 2 458441 AW842283 Hs. 288232 cyclin 1 2. 1 410705 BE004107 gb : CMO-BN0102-150300-288-fl2BN0102Homo 2. 1 444647 H14718 Hs. 11506 Humandone23589mRNAsequence 2. 1 405502 C7000609-: gil628012lpirl ; A53933 myosin 1 2. 1 400818 Target Exon 2. 1 435059 Z45270 Hs. 235873 hypothetical protein FW22672 2. 1 426559 AB001914 Hs. 170414 paired basic amino acid cleaving system 2. 1 445200 AA084460 Hs. 12409 somatostatin 2. 1 453396 AW162768 Hs. 22620 ESTs 2. 1 443819 AB033076 Hs. 9873 likely homolog of rat kinase D-interacti 2. 1 401929 C17001690 : gil6OO57011reflNP-009099. 11 AT 2. 1 451032 W03692 Hs. 323079 Homo sapiens mRNA ; cDNA DKFZpS64P116 (fr 2. 1 433862 D86960 Hs. 3610 KIAA0205 gene product 2. 1 458694 F12832 Hs. 3610 ESTs 2. 1 417063 N50515 Hs. 45061 ESTs 2. 1 416935 AA190712 gb : zp87fO9. rt Stratagene HeLa cell s3 93 2. 1 414446 AA147534 Hs. 142019 ESTs, Weakly similar to 1207289A reverse 2. 1 434681 AA642402 Hs. 59142 ESTs 2. 1 413835 Al272727 Hs. 249163 fatty acid hydroxyle 2. 1 426137 AL040683 Hs. 167031 DKFZP566D133protein 2. 1 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 2. 1 454339 AW381980 gb : QV4-HT0316-091199-028-d05 HT0316 Homo 2. 1 407786 AA687538 Hs. 38972 tetraspan 1 2. 1 421296 NM_002666 Hs. 103253 penfipin 2. 1 444200 AA327113 Hs. 149057 ESTs 2. 1 409339 AB020686 Hs. 54037 ectonucleoGde pyrophosphataselphosphodi 2. 1 418410 AA811441 Hs. 107393 chromosome 3 open reading frame 4 2. 1 414759 AW295157 Hs. 47587 ESTs 2. 1 449511 A1436187 Hs. 296261 guanine nucleotide binding protein (G pr 2. 1 451606 AA018791 Hs. 7945 AIE-75 binding protein protein 2. 1 437924 Api935344 Hs. 164118 ESTs, Weakly similar to SL51_HUMAN SODIU 2. 1 449119 A1631195 Hs. 232193 ESTs 2. 1 431568 AW972316 Hs. 283703 ESTs 2. 1 447932 AA837474 Hs. 20021 vesicle-associated membrane protein 1 (s 2. 1 433516 AA595802 Hs. 33410 ESTs, Weakly similar to T17279 hypothefi 2. 1 441987 AW452234 Hs. 128293 ESTs 21 414055 AW818687 Hs. 5366 hypothetical protein FW21522 2. 1 445066 BE178734 Hs. 197422 ESTs 2. 1 455546 AW994075 gb : RC3-BN0036-090200-011-g06BN0036Homo 2. 1 413607 T64741 gb : yc48f11. r1 Stratagene liver (937224) 2. 1 456401 W28146 gb : 43f11 Human retina cDNA randomly prim 2. 0 407341 AA918886 Hs. 204918 ESTs, Weakly similar to ALULHUMAN ALU S 2. 0 425055 AW961959 Hs. 96940 ESTs 2. 0 426917 AA913814 Hs. 172854 DKFZP586B0923 protein 2. 0 419647 AA348947 Hs. 91816 hypothetical protein 2. 0 412266 N59006 Hs. 26133 ESTs 2. 0 449658 A1964033 Hs. 195730 ESTs. Weakly similar to CTXN RAT CORTEXI 2. 0 424505 AA446131 Hs. 124918 K) AA1795 protein 2. 0 438219 At916151 Hs. 257194 ESTs 2. 0 425068 AL048716 Hs. 154387 KIAA0103geneproduct 2. 0 412949 A1471639 Hs. 71913 ESTs 2. 0 418866 T65754 gb : yc11c07. s1 Stratagene lung (937210) H 2. 0 445071 Api280246 Hs. 149504 ESTs 2. 0 456529 AF014643 Hs. 100072 connexin46. 6 2. 0 406475 C15000508* : gil25588251gblAAC53387. 11 (AF 2. 0 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 2. 0 431542 H63010 Hs. 5740 ESTs 2. 0 452625 AA724771 Hs. 61425 ESTs 2. 0 410378 R23324 Hs. 41693 DnaJ (Hsp40) homolog, subfamily B, membe 2. 0 409767 AW501470 gb : UI-HF-BPOp ajd-b-03-0-Ul. rl NIH_MGC_5 2. 0 446873 A1554439 Hs. 30724 ESTs 2. 0 453938 AF082569 Hs. 36794 D-type cyclin-interacting protein 1 2. 0 423605 AF047826 Hs. 129887 cadhenn 19, type 2 2. 0 420061 AW024937 Hs. 29410 ESTs 2. 0 439559 AW364675 Hs. 173921 ESTs, Weakly similar to 2109260A B cell 2. 0 449901 A1674072 gb : wd15hO1. x1 Soares_NFL_T_GBC_S1 Homos 2. 0 428304 A1743177 Hs. 98422 ESTs 2. 0 432278 AL137506 Hs. 274256 hypothetical protein FLJ23563 2. 0 458480 Al792298 p30 DBC protein 2. 0 404559 Target Exon 2. 0 445831 NM006055 Hs. 13351 LanC (bacterial lantibiotic synthetae c 2. 0 427523 BE242779 Hs. 179526 upregulated by 1, 25dihydroxyvitamin D-3 2. 0 413055 AV655701 Hs. 75183 cytochrome P450, subfamily IIE (ethanol-2. 0 444904 AW452054 Hs. 161139 ESTs 2. 0 443713 A1082810 Hs. 204934 ESTs 2. 0 448743 AB032962 Hs. 21896 KIAA1136 protein 2. 0 428186 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 2. 0 448770 AA326683 Hs. 21992 likely ortholog of mouse variant polyade 2. 0 453994 BE180964 Hs. 165590 ribosomal protein S13 2. 0 420290 AW977318 Hs. 194480 ESTs 2. 0 431467 N71831 Hs. 256398 Homo sapiens mRNA ; cDNA DKFZp434E0528 (f 2. 0

447965 AW292577 Hs. 94445 ESTs 2. 0 423073 BE252922 Hs. 123119 MAD (mothers against decapentaplegic. Dr 2. 0 459256 AW967468 Hs. 99821 hypothetical protein FU14547 2. 0 411906 AW875765 gb : QV2-PT0012-020500-186-a08PT0012 Homo 2. 0 441984 AB037763 Hs. 8059 synaptotagmin IV 2. 0 437900 A1763301 Hs. 107331 ESTs 2. 0 436092 A1345995 Hs. 127383 ESTs 2. 0 416529 AW009370 Hs. 115772 ESTs 2. 0 414320 U13616 Hs. 75893 ankyr 3, node of Ranvier (ankyrin G) 2. 0 444749 Al190672 Hs. 65926 ESTs 2. 0 446277 A1284218 Hs. 159204 ESTs 2. 0 452550 AA026735 Hs. 326048 Homo sapiens mRNA ; cDNA DKFZp434M0420 (f 2. 0 445725 AK000956 Hs. 13209 hypoGheGcal protein FW10094 2. 0 409265 T78737 Hs. 321062 ESTs 2. 0 426736 AA431615 Hs. 130722 ESTs 2. 0 447098 A1939409 Hs. 157803 ESTs 2. 0 403582 Target Exon 2. 0 TABLE 218 : Pkey : Unique Eos probeset identifier number CAT number : Gene duster number Accession : Genbank accession numbers Pkey CAT Number Accession 409767 1154015_1 AW501470AW502931 AW499500 410705 1217235 1 BE004107 BE004105 AW901093 AW797879 AW901094 AW797881 AW797880 BE004108 410912 12265U_1 AW810224AW810337 AW810295 AW810333 AW810335 AW810Z96 AW816053 411361 1240611_1 AW839073 AW839234 AW839230 AW878302 AW839109 AW843897 411811 12594271 AW864370AW864319AW864504 411906 1265204_1 AW875765H50294AW875444 411918 1265807_1 AW876354 AW876179 AW876318 AW876290 AW876234AW876125 AW876199 AW876198 412244 1284692 1 AW948175 AW947637 AW902869 AW947537 AW947531 AW947532 AW947530 413607 1379911 1 T64741 BE158393 BE152805 414276 1432115-1 BE297862 415666 1543492 1 H72693 R08673 H72694 F20990 R08580 416935 1631791 AA190712AA190665AA252564 418154 17249-1 BE165866 BE165832 AA319621 AA401166 A1811901 H78857 X56199 R93797 AW896675 AA401072 AW374411 H52942 AW896685 AA348138 Al399764 M010244 W90159 N90874 AA339496 AW967136 W38705 AA029093 AW444647 BE175700 AV651656 AV651847 AA332039 AV649227 AV649164 AV649491 N87956 AA332262 BE001561 H75493 BE218742 AA333298 AA095633 AA091968 M78602 T05342 W17094 M126501 AW374665 A1452905 AW316900 A1185080 A1202928 A1651843 AA69354i A1681019 AV658257 AV658133 BE045335 BE089546 AA300830 AA361376 BE218739 AW207622 AA765340 AW612733 BE348741 AI806054 AI871563 AA808652 AI500693 AW342032 AA147066 418866 179788 1 T65754 AA229857 AA229658 419386 184356 1 AA236867 AA237066 AA354236 AW957759 H08961 424994 245786_1 AW954525 Al372685 M349501 Al372687 H10564 427493 279541_2 H09037 AW974937 AA657521 H86138 H86513 H09016 AA404410 AA404454 431304 331286 1 BE157283 BE157287 AA502438 432408 3462862 N39127 F20776 A1082691 AA865520 F36964 F33894 433670 372721 1 AA604405 BE062234 AW748386 433921 377350J AA618174Ai114549R36464R36465 436624 4237_5 T64297 AA894931 NM001443 M10050 AW843109 A1698516 T53219 T48785 T64166 AA706930 R29613 T55913 T56518 T64679 R29666 M10617 A1768596 AA101894 W90338 A1742193 AW752206 AA099433 T53220 AW082135 AW272775 T29562 T55862 Al343047 Al345671 T68235 T68121 AW842284 446692 689623 1 Z44514 A1352097 A1803984 AW235923-AW196558 A1954637 Al336983 449901 818599 1 A1674072 BE268487 454339 1122972_1 AW381980 BE15Z44 BE152235 BE152238 BE1SZ32 455040 1250026_1 AW852286 AW851934 AW652096 AW852274 455546 1324614 1 AW994075 AW994386 455649 13487081 BE065051 BE155165 BE064764 BE155231 BE064648 BE064671 BE064636 456401 1844649_2 W28146W28187 458480 59843-1 A1792298 H 14121 A1375113 AA960851 AA744592 AV648739 Al 298360 AW293609 TABLE 21C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et refers to the publication entitled'The DNA sequence of human chromosome 2Y Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 400536 9797380 Minus 170994-172025 400818 8569994 Plus 172644-172765, 173085-173200 401586 9838242 Minus 93974-94099 401600 4388746 Minus 27363-27518. 28727-28891, 29526-29731 401783 7249190 Plus 139369-139827, 140509-140591, 140834-140990, 14149&141657, 141757-141882, 14206142283 401929 3810670 Minus 3167-3286, 4216-4310 402124 4033680 Plus 164206-164459 402493 9797670 Minus 20514&205240, 205428-205542 403463 9929538 Plus 102596-102879 403469 9929739 Minus 4831-7707 403582 8101186 Plus 18308-18458 403728 7534291 Minus 34481-34671 404091 7684554 Minus 82121-83229 404559 8748893 Minus 73499-73651. 89575-89739

404563 9838310 Plus 100136-100343 404606 9212936 Minus 22310-23269 404659 9797068 Minus 65026-67930 404746 7219894 Minus 32643-32834 405354 2642452 Plus 52213-53089 405403 6850244 Minus 37491-37670. 40951-41031 405502 9211311 Minus 50360-50584 405715 4156209 Plus 26293-26706 406023 8272661 Plus 205623-205936 406475 9797684 Plus 125417-125563, 128052-128180 TABLE 22A : ABOUT 301 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS Table 22A lists about 301 genes significanoy down-regulated in glioblastoma compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymetdx/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to'average'glioblastoma was greater than or equal to 2. The'average'normal CNS level was set to the 75t pencenUle anongst various normal CNS tissues. The average gliobiatoma level was set to the 9511 percentile armngst various tumor samples. In order to remove gene- specific background levels of non-specific hybridization, the 10'^ percentile value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of CNS to GLIOBLASTOMA Pkey ExAccn UnigenelD Unigene Title R1 418318 U47732 Hs. 84072 transmembrane 4 superfamily member 3 10. 1 445529 H14421 Hs. 180513 ATP-bindingcassete, sub-familyA (ABC1 9. 4 415274 AF001548 Hs. 78344 myosin, heavy polypeptide 11, smooth mus 7. 5 417167 AW206437 Hs. 4290 ESTs 7. 3 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 6. 5 454076 AW204712 Hs. 61957 ESTs 6. 3 417275 X63578 Hs. 295449 parvalbumin 6. 2 412636 NM 004415 desmoplakin (DPI, DPII) 6. 0 409743 N48721 Hs. 183506 hypotheGcal protein FLJ14213 5. 9 424645 NM_014682 Hs. 151449 KlM0535geneproduct 5. 6 427322 AK002017 Hs. 176227 hypotheticalprotein FLJ11155 5. 5 446390 AA233393 Hs. 14992 hypothetical protein FU 11151 5. 2 444409 A1792140 Hs. 49265 ESTs 5. 2 409031 AA376836 Hs. 288856 ESTs 5. 1 408428 NM 014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 4. 8 428414 AL049980 Hs. 184216 DKFZP564C152 protein 4. 8 428874 W32133 Hs. 194366 transthyretn (prealbumin, amyloidosis t 4. 6 420605 BE391491 Hs. 99291 HSPC156 protein 4. 6 445618 H79667 Hs. 237642 HomosapienscDNAFW12052fis, cloneHE 4. 6 450715 Al266484 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 4. 4 428508 BE252383 Hs. 184668 SB8131 protein 4. 4 434064 AL049045 Hs. 180758 hypothetical protein PR00082 4. 3 410330 AW023630 Hs. 159425 ESTs 4. 2 426471 M22440 Hs. 170009 transforming growth factor, alpha 4. 2 409231 AA446644 Hs. 692 GA733-2 antigen ; epithelial glycoprotein 4. 2 448958 AB020651 Hs. 22653 KIAA0844 protein 4. 2 428465 AW970976 Hs. 293653 ESTs 4. 0 429470 Api878901 Hs. 203862 guanine nucleotide binding protein (G pr 4. 0 432298 AL118812 Hs. 274293 HomosapiensmRNA ; cDNADKFZp761G1111 (f 3. 9 427061 AB032971 Hs. 173392 KlM1145protein 3. 9 430261 AA305127 Hs. 237225 hypothetical protein HT023 3. 9 435145 A1277259 Hs. 116631 ESTs 3. 8 416101 R24854 Hs. 268806 ESTs 3. 8 426716 NM006379 Hs. 171921 sema domain, immunoglobulin domain (Ig), 3. 8 438202 AW169287 Hs. 22588 ESTs 3. 8 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheti 3. 7 419956 AL137939 Hs. 40096 ESTs 3. 7 430573 AA744550 Hs. 136345 ESTs 3. 7 422546 AB007969 Hs. 301478 KIAA0500 protein 3. 7 453344 BE349075 Hs. 44571 ESTs 3. 6 417620 R02530 Hs. 191198 ESTs 3. 6 421952 AA300900 Hs. 98849 ESTs, ModeratelysimilartoAF1615111 H 3. 6 414631 AW970130 Hs. 65406 ESTs 3. 6 437073 A1885608 Hs. 94122 ESTs 3. 5 441264 AA927170 Hs. 23290 ESTs 3. 5 433629 R13140 Hs. 13359 ESTs 3. 5 415114 D60468 Hs. 94181 ESTs 3. 4 411770 NM 014278 Hs. 71992 heat shock protein (hsp 110 family) 3. 4 415666 H72693 gb : yuO3c11. r1Soaesétalliverspleen 3. 4 416851 AW963951 Hs. 85618 ESTs 3. 4 443037 AW500305 Hs. 8906 syntaxin 7 3. 4 449511 A1436187 Hs. 296261 guanine nucleotide binding protein (G pr 3. 4 427176 AW381569 Hs. 40334 ESTs 3. 4 438704 A1435060 Hs. 32825 ESTs 3. 3 417175 R44558 Hs. 94002 ESTs 33 430865 A1073424 Hs. 5232 HSPC125 protein 3. 3 457012 R41480 Hs. 302754 ESTs 3 3 405354 CX000321 : gil6671s79lreqNp 031518. 11 an 3. 3 432799 NM_016161 Hs. 278960 afpha-1, 4-N-acetylglucosaminylUansferas 3. 3

429876 AB028977 Hs. 225974 KIAA1054 protein 3. 3 434348 BE393191 Hs. 181795 putative b, b-caratene-9', 10'-dioxygenase 3. 3 441071 D79550 Hs. 7149 Homo sapiens cDNA : FU21950 fis, clone H 3. 3 445279 R41900 Hs. 22245 ESTs 3. 2 414541 BE293116 Hs. 76392 aldehyde dehydrogenase 1 family, member 3. 2 448072 A1459306 Hs. 24908 ESTs 3. 2 402429 Target Exon 3. 2 433328 AW298159 Hs. 23644 ESTs, Weakly similar to S65824 reverse t 3. 2 400138 Eos Control 3. 1 414327 BE408145 Hs. 185254 ESTs, WeaklysimilartoT24435hypotheG 3. 1 459399 BE407712 Hs. 153998 ereatinekinase. mitochondria) 1 (ubiqui 3. 1 433582 BE548749 Hs. 148016 ESTs 3. 1 434104 AF116691 Hs. 116459 hypothetical protein PR02198 3. 0 404606 Target Exon 3. 0 407173 T64349 gb : yclOdO8. sl Stratagenetung (937210) H 3. 0 415672 N53097 Hs. 193579 ESTs 3. 0 448583 NM_015239 Hs. 21542 KIAA1035 protein 3. 0 429043 A1824977 Hs. 145319 ESTs 3. 0 439165 AA029517 Hs. 95162 KCNQ1 overlapping transcript 1 2. 9 449561 A1022240 Hs. 17924 ESTs. Moderately similar to AWI-HUMAN A 2. 9 436427 A1344378 Hs. 143399 ESTs 2. 9 405403 Target Exon 2. 9 452197 AW023595 Hs. 232048 ESTs 2. 9 437357 AL359559 Hs. 331666 Homo sapiens mRNA ; cDNA DKFZp76202215 (f 2. 9 439272 AA832474 Hs. 25851 ESTs 2. 9 415839 R40611 Hs. 94694 ESTs Z9 411906 AW875765 gb : QV2-PT0012-020500-186-a08PT0012Homo 2. 9 409403 AA668224 Hs. 6634 Homo sapiens cDNA : FU22547 fis, clone H 2. 9 412258 AA376768 Hs. 324841 hypothetical protein FU22622 2. 8 435836 AW292532 Hs. 343667 homolog of yeast long chain polyunsatura 2. 8 433109 N58907 Hs. 162430 EST 2. 8 404563 Target Exon 2. 8 427974 BE093023 Hs. 188767 ESTs 2. 8 413324 V00571 Hs. 75294 corticotropin releasing hormone 2. 7 409263 AA069573 Hs. 50319 ESTs 2. 7 454247 AJ243950 Hs. 46735 deafness locus associated putative guani 2. 7 449180 A1633836 Hs. 195649 ESTs 2. 7 416004 D11880 Hs. 299254 HomosapienscDNA : FU23597 fis, clone L 2. 7 424994 AW954525 gb : EST366595 MAGE resequences, MAGC Homo 2. 7 430371 D87466 Hs. 240112 KIAA0276 protein 2. 7 449117 AW449310 Hs. 210262 ESTs, WeaklysimilartoHSS2_HUMANHEPAR 2. 7 451007 H38108 Hs. 32759 ESTs 2. 7 414502 AL133721 Hs. 224680 ESTs 2. 7 458793 N80159 Hs. 121849 microtubule-associated proteins 1A/1B li 2. 7 459053 A1807052 Hs. 210361 ESTs 2. 7 427229 A1799751 Hs. 5635 ESTs 2. 7 425649 U30930 Hs. 158540 UDP glycosyltransferase 8 (UDP-galætose 2. 7 444922 A1921750 Hs. 144871 Homo sapiens cDNA FW13752 fis, clone PL 2. 7 433921 AA618174 gb : nql4fOt. sl NCI_CGAP Thyl Homosapiens 2. 7 414272 A1651603 Hs. 46988 ESTs 2. 7 418047 R37633 Hs. 4847 ESTs 2. 7 421089 AB037771 Hs. 101799 KIAA1350 protein 2. 7 416498 U33632 Hs. 79351 potassium channel, subfamily K, member 1 2. 6 414290 A1568801 Hs. 71721 ESTs 2. 6 433703 AA210863 Hs. 3532 nemo-like kinase 2. 6 408739 W01556 Hs. 238797 ESTs, Moderately similar to 138022 hypot Z6 414602 AW630088 Hs. 76550 Homo sapiens mRNA ; cDNA DKFZp564B1264 (f 2. 6 422137 AJ236885 Hs. 112180 zinc finger protein 148 (pHZ-52) 2. 6 442023 Al187878 Hs. 144549 ESTs 2. 6 421709 AA159394 Hs. 107056 CED-6 protein 2. 6 426747 AA535210 Hs. 171995 kallikrein 3, (prostate specific antigen 2. 6 412244 AW948175 gb : RCO-MT0013-280300-021-c10 MT0013 Homo 2. 6 419386 AA236867 ESTs. Weakly similar to 138022 hypotheti 2. 6 423665 BE167153 Hs. 24380 ESTs 2. 6 430320 BE245290 Hs. 239218 uncharacterized hypothalamus protein HCD 2. 6 408468 A1909712 Hs. 93837 phosphatidylinositoltransferprotein, m 2. 6 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 2. 6 448871 BE616709 Hs. 159265 kruppel-elatedzincfingerproteinhcKr 2. 6 414516 Api307802 Hs. 135560 ESTs, Weakly similar to T43458 hypothefi 2. 6 459080 AW192083 Hs. 290855 ESTs 2. 5 455040 AW852286 gb : QVO-CT0225-100400-187-d08CT0225Homo 2. 5 435712 AA694607 Hs. 176956 ESTs 2. 5 431662 AA513406 Hs. 152307 ESTs 2. 5 435902 AA701867 Hs. 297726 ESTs 2. 5 436624 T64297 fatty acid binding protein 1, liver 2. 5 443155 R54485 Hs. 23772 ESTs 2. 5 439183 AW970600 Hs. 303261 ESTs Z5 426365 AA376667 Hs. 10283 RNA binding motif protein 88 2. 5 420033 D59502 Hs. 292590 ESTs 2. 5 408438 AB011180 Hs. 100960 KIAA0608 protein 2. 5 440205 T86950 Hs. 105448 ESTs, Weakly similar to 834087 hypotheti 2. 5 448786 BE048842 Hs. 179075 HomosapienscDNAFW11881 fis, cloneHE 2. 5 432251 AW972983 Hs. 232165 polycythemia rubra vera 1 ; cell surface 2. 5

427115 AW972853 Hs. 112237 ESTs 2. 4 433670 AA604405 gb : no87hO9. sl NO CGAP_M1 Homosapiens 2. 4 452022 AW072330 Hs. 293875 ESTs 2. 4 408814 N62499 Hs. 176227 hypothetical protein FLJ11155 2. 4 403469 Target Exon 2. 4 450374 AA397540 Hs. 60293 Homo sapiens clone 122482 unknown mRNA 2. 4 451926 AW134519 Hs. 96125 Homo sapiens, Similar to clone FLB3816, 2. 4 443622 A1911527 Hs. 11805 ESTs 2. 4 456791 H05202 Hs. 133968 FGF receptor activating protein 1 2. 4 414672 Al218038 Hs. 48504 ESTs, Moderately similar to ALU5 HUMAN A 2. 4 451522 8E565817 Hs. 26498 hypothetical protein FU21657 2. 4 422414 AW875237 Hs. 13701 ESTs 2. 4 425383 D83407 Hs. 156007 Down syndrome critical region gene 1-lik 2. 4 438086 AA336519 Hs. 83623 nuclear receptor subfamily 1, group 1, m 2. 4 410240 AL157424 Hs. 61289 synaptoianin 2 2. 4 432408 N39127 ESTs, Weakly similar to A46010 X-linked 2. 4 458227 Z40670 Hs. 181340 ESTs Z4 431325 AW026751 Hs. 5794 ESTs, Weakly similar to 2109260A B cell 2. 4 401600 BE247275 USsnRNP-specificprotein, 116kD 2. 3 422963 M79141 Hs. 13234 ESTs 2. 3 444897 AW137088 Hs. 144857 ESTs 2. 3 418207 C14685 Hs. 34772 ESTs 2. 3 445071 A1280246 Hs. 149504 ESTs 2. 3 407868 Nom000950 Hs. 40637 pnoline-rich Gia (G-carboxyglutamic æid 2. 3 433331 A1738815 Hs. 117323 ESTs 2. 3 440293 A1004193 Hs. 22123 ESTs 2. 3 428850 AA934975 Hs. 185076 ESTs 2. 3 401783 NM003771' : Homo sapiens keratin, hair, a 2. 3 419763 A1039691 Hs. 127486 ESTs 2. 3 416018 AW138239 Hs. 78977 proprotein convertase subtilisin/kexin t 2. 3 420912 AW853156 Hs. 90787 ESTs 2. 3 442097 AW015799 Hs. 128474 ESTs 2. 3 425907 AA365752 Hs. 155965 ESTs 2. 3 404091 Target Exon 2. 3 414106 BE300325 Hs. 77135 RNA binding protein 2. 3 454288 BE222648 Hs. 241432 ESTs, Highlysimilartoc380A1. 1b [H. sap 2. 3 441040 AW449782 Hs. 178803 ESTs 2. 3 424724 T06532 Hs. 287709 Homo sapiens cDNA : FU22674 fis, clone H 2. 3 441879 AI521936 Hs. 107149 novel protein similar to archaeal, yeast 2. 3 407988 N47760 Hs. 285107 hypothetical protein FLJ13397 2. 2 452420 BE564871 Hs. 29463 centrin, EF-hand protein, 3 (CDC31 yeast 2. 2 458676 A1692464 Hs. 202263 ESTs 2. 2 418407 AL044818 Hs. 84928 nuclear transcription factor Y, beta 2. 2 453938 AF082569 Hs. 36794 D-type cyclin-interacting protein 1 2. 2 407978 AW385129 Hs. 41717 phosphodiesterase tA, calmodulin-depende 2. 2 420548 AA278246 Hs. 920 ESTs 2. 2 422907 A1879263 Hs. 77273 Human glucose transporter pseudogene 2. 2 446351 AW444551 Hs. 35380 x 001 protein 2. 2 442117 AW664964 Hs. 128899 ESTs ; hypothetical protein for ! MAGE : 447 2. 2 429598 AA811257 Hs. 269710 ESTs 2. 2 408480 A1350337 Hs. 164568 fibrobiast growth factor 7 (keratinocyte 2. 2 411361 AW839073 gb : CM2-LT0066030100-109406LT0066Homo 2. 2 459697 AA406062 Hs. 98002 ESTs 2. 2 409856 AW502082 gb : UI-HF-BROp-ajq-g-040-Ul. r1 NIH_MGC_5 2. 2 444760 A1796296 Hs. 208062 ESTs 2. 2 443258 AF169301 Hs. 9098 sulfate transporter 1 2. 2 428206 AB020643 Hs. 183006 KIAA0836 protein 2. 2 410119 F07841 Hs. 13926 ESTs 2. 2 413427 U31120 Hs. 845 interteukin 13 2. 2 438021 AV653790 Hs. 324275 WW domain-containing protein 1 2. 2 428652 AA584272 Hs. 336224 transmembrane protein with EGF-like and 2. 2 429655 U48959 Hs. 211582 myosin, light polypeptide kinase 2. 2 424153 AA451737 Hs. 141496 MAGE-like 2 2. 2 413303 AW836130 Hs. 75277 hypothetical protein FU13910 2. 2 427287 NM 014903 Hs. 174188 KIAA0938 protein 2. 2 449658 A1964033 Hs. 195730 ESTs, Weakly similar to CTXN RAT CORTEXI 2. 2 441984 AB037763 Hs. 8059 synaptotagmin IV 2. 2 449709 BE410592 Hs. 23918 hypothetical protein PP5395 2. 2 408068 AW148652 Hs. 167398 ESTs 2. 2 407819 R42185 Hs. 102720 ESTs 2. 2 414203 BE262170 Hs. 78629 ATPase, Na ? transporting, beta I polypep 2. 2 454339 AW381980 gb : QV4-HT0316-091199-028-d05 HT0316 Homo 2. 2 448045 AJ297436 Hs. 20166 prostate stem cell antigen 2. 2 458480 A1792298 p30 DBC protein 2. 2 449835 AW979300 Hs. 293813 ESTs 2. 2 458547 AW204314 Hs. 170784 ESTs 2. 2 411678 A1907114 Hs. 71465 squalene epoxidase 2. 1 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 2. 1 424632 AB014523 Hs. 151406 KIAA0623 gene product 2. 1 449901 Al674072 gb : wd15h01. x1SoaresNFLTGBCS1 Homos 2. 1 431583 AL042613 Hs. 262476 S-adenosylmethioninedecarboxylae1 2. 1 410538 AW753115 gb : PMO-CT0248-131099-001-h12 CT0248 Homo 2. 1 426775 AA384564 Hs. 3628 ESTs 2. 1

433862 D86960 Hs. 3610 KIAA0205 gene product 2. 1 458694 F12832 Hs. 3610 ESTs 2. 1 417063 N50515 Hs. 45061 ESTs 2. 1 416935 AA190712 gb : zp87fO9. ri Stratagene HeLa cell s3 93 2. 1 436489 AJ272269 Hs. 121429 zinc-binding protein Rbcc728 2. 1 431128 A1203545 Hs. 296169 Sphase response (cyclin-related) 2. 1 442310 AF033199 Hs. 8198 zinc finger protein 204 2. 1 432434 AL161977 Hs. 2994 PCTAIRE protein kinase 3 2. 1 400339 X57131 Hs. 248209 H2A histone family, member F, pseudogene 2. 1 432266 AK000385 Hs. 274222 hypothetical protein FU20378 2. 1 414759 AW295157 Hs. 47587 ESTs 2. 1 438219 At916151 Hs. 257194 ESTs 2. 1 451336 A1264643 Hs. 3610 ESTs 2. 1 430538 AB032435 Hs. 242821 differentiation-associated Na-dependent 2. 1 413493 BE144444 gb : MRO-HT0168-141199-002-fO9HT0168Homo 2. 1 428501 AL041162 Hs. 98587 ESTs 2. 1 431568 AW972316 Hs. 283703 ESTs 2. 1 456177 NM 012391 Hs. 79414 prostate epithelium-specific Ets transcr 2. 1 441976 AA428403 Hs. 106131 ESTs 2. 1 421311 N71848 Hs. 283609 hypothetical protein PR02032 2. 1 428358 AA993222 Hs. 101915 Stargardt disease 3 (autosomal dominant) 2. 1 439973 A1733308 Hs. 124663 ESTs 2. 1 446185 Al279191 Hs. 149454 ESTs, WeaklysimilartoDSR6_HUMANDOWN 2. 1 451606 AA018791 Hs. 7945 AIE-75 binding protein protein 2. 1 433516 AA595802 Hs. 33410 ESTs. Weakly similar to T17279 hypotheG 2. 1 441987 AW452234 Hs. 128293 ESTs 2. 1 457140 A1279960 Hs. 178140 ESTs 2. 1 414055 AW818687 Hs. 5366 hypothetical protein FW21522 2. 1 445066 BE178734 Hs. 197422 ESTs 2. 1 459265 Au003616 gb : AJ003616 Selected chromosome 21 cDNA 2. 0 425337 AA355442 Hs. 169054 ESTs 2. 0 409339 AB020686 Hs. 54037 ectonucleoGde pyrophosphatase/phosphodi 2. 0 453023 AW028733 Hs. 31439 serine protease inhibitor, Kunitz type, 2. 0 425055 AW961959 Hs. 96940 ESTs 2. 0 425068 AL048716 Hs. 154387 KlM0103geneproduct 2. 0 444700 NM003645 Hs. 11729 fatty-acid-Coenzyme A ligase, very long-2. 0 424823 NM006226 Hs. 153322 phospholipase C, epsilon 2. 0 450103 R08665 Hs. 17244 hypothetical protein FU13605 2. 0 448519 AW175665 Hs. 278695 Homo sapiens prostein mRNA, complete cds 2. 0 440808 AK001339 Hs. 7432 hypothetical protein FU10477 2. 0 429968 AA322503 Hs. 227011 G-substrate 2. 0 429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 2. 0 433068 NM006456 Hs. 288215 sialyltransferae 2. 0 416982 J05401 Hs. 80691 creatine kinase, mitochondfial 2 (sarcom 2. 0 423479 NM014326 Hs. 129208 death-associated protein kinase 2 2. 0 407341 AA918886 Hs. 204918 ESTs. Weakly similar to ALU8_HUMAN ALU S 2. 0 452625 AA724771 Hs. 61425 ESTs 2. 0 410378 R23324 Hs. 41693 DnaJ (Hsp40) homolog, subfamily B, membe 2. 0 409767 AW501470 gb : UI-HF-BPOp-ajd-b-03-0-Ul. r1 NIH MGC 5 2. 0 415925 H09474 Hs. 202341 Homo sapiens cDNA : FLJ23573 fis, clone L 2. 0 405670 C2000627' : gil12034653lgbjMG45951. 1 jAF22 2. 0 408206 AF041853 Hs. 43670 kinesin family member 3A 2. 0 458660 A1299739 Hs. 99601 hypothetical protein FU12553 2. 0 432278 AL137506 Hs. 274256 hypothetical protein FU23563 2. 0 404559 Target Exon 2. 0 403728 Target Exon 2. 0 413055 AV655701 Hs. 75183 cytochrome P450, subfamily IIE (ethanol-2. 0 407786 AA687538 Hs. 38972 tetrapan 1 2. 0 413266 BE300352 gb : 600944231F1 NIH_MGC_17 Homo sapiens c 2. 0 453994 BE180964 Hs. 165590 ribosome protein S13 2. 0 451583 A1653797 Hs. 24133 ESTs 2. 0 443244 A1457235 Hs. 166479 ESTs 2. 0 453396 AW162768 Hs. 22620 ESTs 2. 0 415694 AW194301 Hs. 339283 Human DNA sequence from clone RP1-1 87J 11 2. 0 459511 Al142379 gb : qg64cO1. rl Soares testis NHT Homo sap 2. 0 450757 BE081050 Hs. 31576 ESTS, Weakly similar to KIAAL 324 protein 2. 0 451032 W03692 Hs. 323079 Homo sapiens mRNA ; cDNA DKFZp564P116 (fr 2. 0 440509 BE410132 Hs. 134202 ESTs. Weakly similar to T17279 hypotheti 2. 0 444647 H14718 Hs. 11506 Human clone 23589 mRNA sequence 2. 0 447932 AA837474 Hs. 20021 vesicle-associated membrane protein 1 (s 2. 0 444749 A1190672 Hs. 65926 ESTs 2. 0 446277 A1284218 Hs. 159204 ESTs 2. 0 452550 AA026735 Hs. 326048 Homo sapiens mRNA ; cDNA DKFZp434M0420 (f 2. 0 453843 D25215 Hs. 35804 hect domain and RLD 3 2. 0 445725 AK000956 Hs. 13209 hypothetical protein FLJ10094 2. 0 409265 T78737 Hs. 321062 ESTs 2. 0 TABLE 228 : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession

409767 1154015 1 AW501470 AW502931 AW499500 409856 1156268 i AW502082 AW502979 AW502807 AW501876 410538 1207341-1 AW753115AW753113R45779 411361 1240611 1 AW839073AW839234 AW839230AW878302 AW839109 AW843897 411906 1265204 1 AW875765 H50294 AW875444 412244 1284692_1 AW948175 AW947637 AW902869 AW947537 AW947531 AW947532 AW947530 412636 13165_1 NM 00441 S AL031058 M77830 BE149760 AW752599 AWB48723 AW376697 AW376817 AW376699 AW848371 AW376782 AW848789 AW361413 AW849074 AW997139 AW799304 AW799309 BE077020 BE077017 BE185187 AW997196 BE156621 BE179915 BE006561 BE143155 AW890985 BE002107 AW103521 AA857316 AW383133 BE011378 AW170253 BE185750 AW886475 BE160433 J05211 BE082576 BE082584 BE004047 AW607238 AW377700 AW377699 BE082526 BE082505 BE082507 BE082514 AW178000 AW177933AI905935 AW747877 AW748114 BE148516 AW265328 AW847678 AW847688 AW365151 AW365148 AW365153 AW365156 AW365175 AW365157 AW365154 AW068840 BE005272 AW365145 BE001925 BE182166 BE144243 BE001923 A1951766 Al434518 BE164920 BE184933 Al284090 BE184941 AW804674 BE184924 C04715 W39488 AW995615 BE184948 BEi 59646 AW606653 AA099891 AA131128 AA337270 AA340777 AW384371 AA852212 R58704 AW366566 AW364859 AA025851 AA025852 AA455100 AA719958 AW352220 AW996245 BE165351 BE073467 AA377127 AW890264 AW609750 AW391912 AW849690 T87267 AW853812 AA852213 W74149 BE009090 AA056401 H91011 AW368529 AW390272 C18467 AW674920 N57176 AA026480 AW576767 H93284 AA026863 AW177787 AA026654 AW177786 BE092134 BE092137 BE092136 AW177784 A1022862 BE091653 AW376811 AW848592 AA040018 BE185331 BE182164 AA368564 AW951576 T29918 AA131077 W95048 W25458 AW205789 H90899 N29754 W32490 R20904 BE167181 BE167165 N84767 H27408 H30146 190590 C03378 Al554403 Al205263 M128470 Al392926 AF139065 AW370813 AW370827 AW798417 AW798780 AW798883 AW798569 R33557 AA149190 C03029 AW177783 AA088866 AW370829 AA247685 BE002273 Al760816 Al439101 AW879451 A1700963 AA451923 A1340326 A1590975 T48793 Al568096 Al142882 M039975 Al470146 M946936 BE067737 BE067786 W19287 AA644381 AA702424 A1417612 A1306554 AI686869 AI568892 AW190555 AI571075 AI220573 AA056527 AI471874 AI304772 AW517828 AS15596 Al627383 Al270345 AW021347AW166807 AW105614 AI346078 AA552300 W95070 A1494069 A1911702 AA149191 AA026864 A1830049 A1887258 AW780435 AI910434 AI819984 AI858282 A1078449 A1025932 AI860584 AI635878 AA026047 AA703232 D12062 AW192085 AA658154 AW514597 AW591892 T87181 AA782066AW243815 AW150038 AW268383 AW004633 AI927207 AA782109 AW473233 AI804485 AW169216AI572669 AA602182 AW015480 AW771865 AI270027 AA961816 AA283207 A1076962 AI498487 AI348053 AI783914 H44405 AW799118 AA128330 AA515500 AA918281 W02156 Al905927 AA022701 W38382 R20795 T77861 AW860878 413266 1356260-1 BE300352 BE299274 BE075351 BE297444 413493 1373555_1 BE144444 BE144430 415666 1543492_1 H72693 R08673 H72694 F20990 R08580 416935 163179 1 AA190712 AA190665 AA252564 419386 184356 1 AA236867 AA237066 AA354236 AW957759 H08961 424994 245786 1 AW954525 A1372685 AA349501 A1372687 H10564 432408 346286_2 N39127F20776AI082691 M865520F36964F33894 433670 372721 1 M604405 BE062234 AW748386 433921 377350 1 AA618174 AI114549 R36464 R36465 436624 4237_5 T64297 AA894931 NM_001443 M10050 AW843109 Al698516 TS3219 T48785 T64166 AA706930 R29613 T55913 T56518 T64679 R29666 M10617 AI768596 AA101894 W90338 AI742193 AW752206 AA099433 T53220 AW082135 AW272775 T29562 T55862 Al343047 Al345671 T68235 T68121 AW842284 449901 818599 1 A1674072 BE268487 454339 1122972 1 AW381980 BE152244 BE152235 BE152238 BE152232 455040 12500281 AW852286AW851934AW852096AW852274 458480 59843 1 A1792298 H14121 A1375113 AA960851 AA744592 AV648739 A1298360 AW293609 459265 966590 1 AJ003616 AJ003654 AJ003617 TABLE 22C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al."efers to the pubticaGon entitled'The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 401600 4388746 Minus 27363-27518, 28727-28891, 29526-29731 401783 7249190 Plus 139369-139827, 140509-140591, 140834-140990, 14149G141657, t41757-141882, 142063142283 402429 9796372 Minus 57622-57793, 59282-59402, 59624-59827 403469 9929739 Minus 4831-7707 403728 7534291 Minus 34481-34671 404091 7684554 Minus 82121-83229 404559 8748893 Minus 73499-73651, 89575-89739 404563 9838310 Plus 100136-100343 404606 9212936 Minus 22310-23269 405354 2642452 Plus 52213-53089 405403 6850244 Minus 37491-37670, 40951-41031 405670 4662655 Plus 96543-96870 TABLE 23A : ABOUT 441 GENES SIGNIFICANTLY DOWN-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS Table 23A lists about 441 genes significantly down-regulated in lower grade glioblastoma (LGG) compared to normal adult CNS tissues. These were selected from 59680 probesets on the AffymeUix/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to'average'LGG was greater than or equal to 2. 5. The'average'normal CNS level was set to the 75", percentile amongst various normal CNS tissues. The'average'LGG level was set to the 95'h percenfile amongst va6ous tumor samples. In order to remove gene-specific background levels of non-specific hybridization, the 10"'percentile value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of CNS to LOWER GRADE GLIOBLASTOMA Pkey ExAccn UnigenelD Unigene Title R1 415388 AF018081 Hs. 78409 collagen, type XVIII, alpha 1 10. 3 418318 U47732 Hs. 84072 transmembrane 4 superfamily member 3 10. 1 445529 H14421 Hs. 180513 ATP-binding cassette, sub-family A (ABC1 9. 9 417433 BE270266 Hs. 82128 5T4 oncofetal trophoblast glycoprotein 7. 8

422746 NM_004484 Hs. 119651 glypican3 7. 7 448362 AA641767 Hs. 21015 hypothetical protein DKFZp564L0864 simil 7. 7 430573 AA744550 Hs. 136345 ESTs 7. 6 415274 AF001548 Hs. 78344 myosin, heavy polypeptide 11, smooth mus 7. 5 419290 A1128114 Hs. 112885 spinal cord-derived growth factor-B 7. 4 424670 W61215 Hs. 116651 epithelial V-like antigen 1 7. 3 417167 AW206437 Hs. 4290 ESTs 7. 3 416018 AW138239 Hs. 78977 proprotein convertae subUíisin/kexin t 7. 3 424632 AB014523 Hs. 151406 KIAA0623 gene product 6. 9 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 6. 5 411770 NM014278 Hs. 71992 heatshockprotein (hsp110family) 6. 5 439272 AA832474 Hs. 25851 ESTs 6. 5 414831 M31158 Hs. 77439 protein kinase, cAMP-dependent regulato 6. 4 454076 AW204712 Hs. 61957 ESTs 6. 3 446390 AA233393 Hs. 14992 hypothetical protein FU 11151 6. 3 430865 A1073424 Hs. 5232 HSPC125 protein 6. 3 434064 AL049045 Hs. 180758 hypothetical protein PR00082 6. 2 417458 NM_005655 Hs. 82173 TGFB inducible eady growth response 6. 1 412636 NM_004415 desmoplakin (DPI, DPII) 6. 0 409743 N48721 Hs. 183506 hypothetical protein FLJ14213 5. 9 430998 AF128847 Hs. 204038 indolethylamine N-methyltransferae 5. 8 434725 AK000796 Hs. 4104 hypothetical protein 5. 6 417175 R44558 Hs. 94002 ESTs 5. 6 417275 X63578 Hs. 295449 parvalbumin 5. 5 427322 AK002017 Hs. 176227 hypotheticalprotein FLJ11155 5. 5 431009 BE 149762 Hs. 48956 gap junction protein, beta 6 (connexin 3 5. 4 420297 Api628272 Hs. 88323 ESTs, Weakly similar to ALU1 HUMAN ALU S 5. 4 412472 AW975398 Hs. 293836 ESTs 5. 4 443258 AF169301 Hs. 9098 sulfate transporter 1 5. 3 427210 BE396283 Hs. 173987 eukaryo6c translation initiation factor 5. 3 442064 A1422867 Hs. 88594 ESTs 5. 2 438868 AW246243 Hs. 334800 hypotheficai protein FU20974 5. 2 444409 A1792140 Hs. 49265 ESTs 5. 2 442310 AF033199 Hs. 8198 zinc finger protein 204 5. 1 409031 AA376836 Hs. 288856 ESTs 5. 1 438460 AB020702 Hs. 6224 KIAA0895 protein 5. 1 411939 A1365585 Hs. 146246 ESTs 5. 0 448429 D17408 Hs. 21223 calponin 1, basic, smooth muscle 5. 0 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 5. 0 408968 Al652236 Hs. 49376 hypothetical protein FU20644 5. 0 443491 AW499665 Hs. 9456 SWIISNF related, matrix associated, acti 4. 9 448960 AF006513 Hs. 22670 chromodomain helicase DNA binding protei 4. 9 416101 R24854 Hs. 268806 ESTs 4. 9 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheti 4. 9 424645 NM014682 Hs. 151449 KIAA0535 gene product 4. 8 437679 NM_014214 Hs. 5753 inositol (myo)-1 (or4)-monophosphatae2 4. 8 408428 NM 014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily 8, membe 4. 8 414502 AL133721 Hs. 224680 ESTs 4. 8 442572 Al001922 Hs. 135121 hypothetical protein FU22415 4. 8 412700 BE222433 Hs. 239208 ESTs, Weakly similar to 138022 hypotheti 4. 8 422603 BE242587 Hs. 118651 hematopoieticaiiy expressed homeobox 4. 8 420605 BE391491 Hs. 99291 HSPC156 protein 4. 7 422482 A1439905 Hs. 344476 gb : ti57g08. x1 NCI CGAP_Lyml2Homosapien 4. 7 416636 N32536 Hs. 42645 solute carrier family 16 (monocarboxylic 4. 7 409263 AA069573 Hs. 50319 ESTs 4. 7 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 4. 6 457216 AA452554 Hs. 283697 ESTs, Weakly similar to A41796 neural re 4. 6 433423 BE407127 Hs. 8997 heat shock 70kD protein 1A 4. 6 449901 A1674072 gb : wdlShO1. xl Soaes-NFL-T-GBc-sl Homos 4. 6 445618 H79667 Hs. 237642 Homo sapiens cDNA FW12052 hs, clone HE 4. 6 431582 F07136 Hs. 261828 G protein-coupled receptor kinase 7 4. 5 424675 NM005512 Hs. 151641 glycoprotein A repetfions predominant 4. 5 449511 A1436187 Hs. 296261 guanine nucleotide binding protein (G pr 4. 5 401600 BE247275 U5 snRNP-specific protein, 116 kD 4. 5 447135 T58148 gb : yb98g06. s1Stratagene lung (937210) H 4. 5 426689 BE245550 Hs. 171825 basic helix-loop-helix domain containing 4. 4 429598 AA811257 Hs. 269710 ESTs 4. 4 428206 AB020643 Hs. 183006 KIAA0836 protein 4. 4 450715 A1266484 Hs. 31570 ESTs, Weakly similar to KIM1324 protein 4 4 428508 BE252383 Hs. 184668 SBBI31 protein 4. 4 435145 A1277259 Hs. 116631 ESTs 4. 4 405670 C2000627-: gij 1 2034653lgblMG45951. 1 AF22 4. 4 442321 AF207664 Hs. 8230 a disintegrin-like and metalloprotease (4. 3 427670 BE612888 Hs. 180224 myosin regulatory light chain 4. 3 428465 AW970976 Hs. 293653 ESTs 4. 3 449180 A1633836 Hs. 195649 ESTs 4. 3 402364 AV653231 CCAAT/enhancer binding protein (CIEBP), 4. 3 426471 M22440 Hs. 170009 transforming growth factor, alpha 4. 2 419386 AA236867 ESTs, Weakly similar to 138022 hypotheti 4. 2 441408 A1733249 Hs. 126897 ESTs 4. 2 419631 AW188117 Hs. 303154 popeye protein 3 4. 2 409231 AA446644 Hs. 692 GA733-2 antigen : epithelial glycoprotein 4. 2 448958 AB020651 Hs. 22653 KIAA0844 protein 4. 2

421878 AA299652 Hs. 111496 Homo sapiens cDNA FW11643 hs, clone HE 4. 2 422278 AF072873 Hs. 114218 frizzled (Drosophila) homolog 6 4. 2 459053 A1807052 Hs. 210361 ESTs 4. 1 450600 BE079478 Hs. 24880 ESTs 4. 1 415839 R40611 Hs. 94694 ESTs 4. 1 450374 AA397540 Hs. 60293 Homosapiensclone 122482unknownmRNA 4. 1 422270 AF114494 Hs. 114062 proteintyrosinephosphatase-like (proli 4. 1 405674 NM 022775 : Homo sapiens hypothetical prot 4. 1 453906 AW444952 Hs. 257054 ESTs 4. 1 419318 AW969742 Hs. 291005 ESTs 4. 0 456382 NM_001126 Hs. 90011 adenylosuccinate synthase 4. 0 435902 AA701867 Hs. 297726 ESTs 4. 0 449483 AK001971 Hs. 23607 hypotheticalprotein FLJ11109 4. 0 434228 Z42047 Hs. 283978 Homo sapiens PR02751 mRNA, complete cds 4. 0 403890 C5002036-: gil10241574lemblCACQ9416. 1l (A 4. 0 429470 Al878901 Hs. 203862 guanine nucleofide binding protein (G pr 4. 0 409856 AW502082 gb : Uf-HF-BROp-ajq-g-04-0-Ul. ri NtH MGC_5 4. 0 443682 AI383061 Hs. 47248 ESTs, Highly similar to similar to Cdc14 4. 0 420230 AL034344 Hs. 284186 forkheadboxC1 4. 0 410509 AW840743 gb : QV1-CN0002-080300-102-f07CN0002Homo 4. 0 428414 AL049980 Hs. 184216 DKFZP564C152 protein 3. 9 400138 Eos Control 3. 9 451522 BE565817 Hs. 26498 hypothetical protein FLJ21657 3. 9 436521 AW203986 Hs. 213003 ESTs 3. 9 401507 C15000810' : gi11131272spP79331ATS2_BO 3. 9 449785 Au225235 Hs. 288300 hypotheGcal protein FLJ23231 3. 9 434815 AF155582 Hs. 46744 corel UDP-galactose : N-acetylgalactosamin 3. 9 411906 AW875765 gb : QV2-PT0012-020500-186a08 PT0012Homo 3. 9 440509 BE410132 Hs. 134202 ESTs, Weakly similar to T17279 hypotheti 3. 9 427061 AB032971 Hs. 173392 K) AA1145 protein 3. 9 430261 AA305127 Hs. 237225 hypothetical protein HT023 3. 9 449658 A1964033 Hs. 195730 ESTs, Weakly similar to CTXN RAT CORTEXI 3. 8 429876 AB028977 Hs. 225974 KIAA1054 protein 3. 8 410330 AW023630 Hs. 159425 ESTs 3. 8 431369 BE184455 Hs. 251754 secretory leukocyte protease inhibitor (3. 8 437659 AB007944 Hs. 5737 KIAA0475 gene product 3. 8 438171 AW976507 Hs. 293515 ESTs 3. 8 418394 AF132818 Hs. 84728 Kruppel-likefætor5 (inteshnal) 3. 8 405586 NM_000299 : Homo sapiens plakophilin 1 (ec 3. 8 432298 AL118812 Hs. 274293 Homo sapiens mRNA ; cDNADKFZp761G1111 (f 3. 8 426716 NM006379 Hs. 171921 sema domain, immunoglobulin domain (1g), 3. 8 438202 AW169287 Hs. 22588 ESTs 3. 8 404606 Target Exon 3. 8 425329 A1961644 Hs. 145444 Homo sapiens cDNA FLJ 11494 fis, clone HE 3. 8 407604 AW191962 Hs. 288061 collagen, type Vlll, alpha 2 3. 8 416498 U33632 Hs. 79351 potassium channel, subfamily K, member 1 3. 7 430868 W93178 Hs. 5232 HSPC125 protein 3. 7 457008 AA410446 Hs. 112011 ESTs, WeaklysimilartounknowníH. sapie 3. 7 458660 A1299739 Hs. 99601 hypothetical protein FU12553 3. 7 408732 AL117490 Hs. 47225 Ras-associated protein Rapt 3. 7 436281 AW411194 Hs. 85195 myelold leukemia factor 1 3. 7 413493 BE144444 gb : MRO-HT0168-141199-002-fO9HT0168Homo 3. 7 418407 AL044818 Hs. 84928 nuclear transcription factor Y, beta 3. 7 445797 Al253414 gb : aq14f04. x1 Stanley Frontal NS pool 2 3. 7 457121 A1743770 Hs. 180513 ESTs, Weakly similar to KIAA0822 protein 3. 6 417620 R02530 Hs. 191198 ESTs 3. 6 421952 AA300900 Hs. 98849 ESTs, Moderately similar to AF161511 1 H 3. 6 454247 AJ243950 Hs. 46735 deafness locus associated putative guani 3. 6 431662 AA513406 Hs. 152307 ESTs 3. 6 426908 AW815163 Hs. 172851 arginase, type 11 3. 6 438519 AI186033 Hs. 147025 ESTs, Weakly similar to C57785 zinc fing 3. 6 415606 W70022 gb : zd5lelO. rl Soares_fetal_heat_NbHH19W 3. 6 444859 AW449137 Hs. 157487 ESTs 3. 6 414631 AW970130 Hs. 65406 ESTs 3. 6 428897 AJ245719 Hs. 194385 hypotheGcal protein FLJ20234 3. 5 437073 A1885608 Hs. 94122 ESTs 3. 5 427287 NM 014903 Hs. 174188 KIAA0938 protein 3. 5 415927 AL120168 Hs. 78919 Kell blood group precursor (McLeod pheno 3. 5 450235 AA007512 Hs. 17538 ESTs 3. 5 447263 AW965667 Hs. 322406 hypothetical protein FLJ14494 3. 5 419440 AB020689 Hs. 90419 KIAA0882 protein 3. 5 427254 AL121523 Hs. 97774 ESTs 3. 5 434348 BE393191 Hs. 181795 puta6veb, b-carotene-9', 10'-dioxygenase 3. 5 441264 AA927170 Hs. 23290 ESTs 3. 5 433629 R13140 Hs. 13359 ESTs 3. 5 446494 AA463276 Hs. 288906 WW Domain-Containing Gene 3. 5 441585 A1760755 Hs. 202383 ESTs 3. 5 438704 A1435060 Hs. 32825 ESTs 3. 4 445279 R41900 Hs. 22245 ESTs 3. 4 415114 D60468 Hs. 94181 ESTs. 3. 4 449561 A1022240 Hs. 17924 ESTs, Moderately similar to ALU1 HUMAN A 3. 4 452420 BE564871 Hs. 29463 contain, EF-hand protein, 3 (CDC31 yeast 3. 4 416517 AA775987 Hs. 79357 proteasome (prosome, macropain) 26S subu 3. 4

441134 W29092 Hs. 346950 cellular retinoic acid-binding protein 1 3. 4 427176 AW381569 Hs. 40334 ESTs 3. 4 415668 AW957684 Hs. 306814 hypothetical protein FU21889 3. 4 450928 Api744417 gb : trlOh12. x1NCI CGAP Ov23Homosapiens 3. 4 457012 R41480 Hs. 302754 ESTs 3. 3 405354 Cl000321 : gil6671579refNP_031518. 1 ari 3. 3 408855 T83061 Hs. 319946 Homo sapiens mRNA for KIAA1727 protein, 3. 3 418525 AW450369 Hs. 86937 ESTs 3. 3 420174 A1824144 Hs. 23912 ESTs 3. 3 437124 AA554458 Hs. 279860 KIAA0666 protein 3. 3 419211 BE270817 Hs. 37617 ESTs, Weakly similar to A53933 myosin 1 3. 3 424335 AW021508 Hs. 28170 ESTs 3. 3 453344 BE349075 Hs. 44571 ESTs 3. 3 428065 A1634046 Hs. 157313 ESTs 3. 3 417248 AA329449 Hs. 247302 twisted gastrulation 3. 3 429415 Nom002593 Hs. 202097 procollagenC-endopepGdaeenhancer 3, 3 411393 AW797437 Hs. 69771 B-factor. properdin 3. 3 406976 M60299 gb : Human alpha-1 collagen type 11 gene, 3. 3 441071 D79550 Hs. 7149 Homo sapiens cDNA : FU21950 fis, clone H 3. 3 414327 BE408145 Hs. 185254 ESTs, Weakly similar to T24435 hypothefi 3. 3 433703 AA210863 Hs. 3532 nemo-like kinase 3. 3 418880 N87353 Hs. 89421 CBF1 interacting corepressor 3. 3 445947 AW612084 Hs. 298494 ESTs 3. 3 437334 AL353947 Hs. 283780 hypothetical protein DKFZp761N1814 3. 3 434795 BE620794 Hs. 4147 translocating chain-associating membrane 3. 2 400127 Eos Control 3. 2 414602 AW630088 Hs. 76550 Homo sapiens mRNA ; cDNA DKFZp564B1264 (f 3. 2 402429 Target Exon 3. 2 428695 A1355647 Hs. 189999 purinergic receptor (family A group 5) 3. 2 427699 AW965076 Hs. 180378 hypothetical protein 669 3. 2 403442 Target Exon 3. 2 419272 AA663904 Hs. 89862 TNFRSF1A-asociated via death domain 3. 2 456614 AV653110 Hs. 106650 hypothetical protein FU20533 3. 2 407581 R48402 Hs. 173508 P3ECSL 3. 2 412633 AF001691 Hs. 74304 penpiakin 3. 2 433328 AW298159 Hs. 23644 ESTs, Weakly similar to S65824 reverse t 3. 2 449294 A1651786 Hs. 195045 ESTs 3. 1 442799 A1564739 Hs. 68505 ESTs 3. 1 434045 A1065133 Hs. 152316 hypothetical protein PR00971 3. 1 409403 AA668224 Hs. 6634 Homo sapiens cDNA : FU22547 fis, clone H 3. 1 420033 D59502 Hs. 292590 ESTs 3. 1 422137 AJ236885 Hs. 112180 zinc finger protein 148 (pHZ-52) 3. 1 444760 A1796296 Hs. 208062 ESTs 3. 1 403488 ENSP00000201948 : KARYOPHERIN BETA28 HOMOL 3. 1 411359 H86088 Hs. 22635 ESTs 3. 1 443037 AW500305 Hs. 8906 syntaxin 7 3. 1 407127 R45970 Hs. 236349 EST 3. 1 416851 AW963951 Hs. 85618 ESTs 3. 1 416838 D84109 Hs. 80248 RNA-binding protein gene with multiple s 3. 1 443030 R68048 Hs. 9238 hypothetical protein FLJ23516 3. 1 410389 AW954049 Hs. 8177 ESTs, Weakly similar to PIHUB6 salivary 3. 1 459399 BE407712 Hs. 153998 ceatine kinase, mitochondrial 1 (ubiqui 3. 1 433582 BE548749 Hs. 148016 ESTs 3. 1 431128 A1203545 Hs. 296169 S-phase response (cyclin-related) 3. 1 420411 A1581085 Hs. 24678 sphingosine-1-phosphatase 3. 1 459584 Api910884 Hs. 346429 ESTs 3. 1 449883 A1004464 Hs. 344156 gb : ol56eO6. s1 Soares_tesGs_NHTHomosap 3. 1 445320 AA503887 Hs. 167011 Homo sapiens cDNA : FU21362 fis, clone C 3. 1 410786 AW803340 gb : IL2-UM0079-090300-050-D02 UM0079 Homo 3. 1 418207 C14685 Hs. 34772 ESTs 3. 0 420521 A1915734 Hs. 87298 ESTs 3. 0 425890 H24530 Hs. 273294 hypothetical protein FLJ20069 3. 0 416749 AW068550. compHs. 79732 fibulin 1 3. 0 412258 AA376768 Hs. 324841 hypothetical protein FU22622 3. 0 407173 T64349 gb : yclOdO8. sl Stratagene lung (937210) H 3. 0 415672 N53097 Hs. 193579 ESTs 3. 0 448583 NM015239 Hs. 21542 KIAA1035 protein 3. 0 429043 A1824977 Hs. 145319 ESTs 3. 0 404091 Target Exon 3. 0 406085 Target Exon 3. 0 438825 BE327427 Hs. 79953 ESTs 3. 0 457441 BE467737 Hs. 146125 ESTs 3. 0 403512 C3000579-: gij1 26433081spl09Y4K1 AIM1_HUM 3. 0 416866 AA297356 Hs. 80324 senne/threonineproteinphosphataecat 3. 0 439877 H39685 Hs. 250700 tryptae beta 1 3, 0 441984 AB037763 Hs. 8059 synaptotagmin IV 3. 0 436765 AB028952 Hs. 5307 synaptopodin 3 0 445071 A1280246 Hs. 149504 ESTs 3. 0 404333 C7001735' : 9il7768636ldbjlBM95483. 1l (AB 3. 0 422907 A1879263 Hs. 77273 Human glucose transporter pseudogene 3. 0 413266 BE300352 gb : 60094423tF1NIH_MGC_17Homosapiensc 3. 0 429393 AA383024 Hs. 201603 Homo sapiens mRNA ; cDNA DKFZp434D0917 (f 3. 0 415337 Z44881 Hs. 9012 ESTs. Weakly similar to S26650 DNA-bindi 3. 0

415044 AA419108 Hs. 77840 annexin A4 2. 9 403469 Target Exon 2. 9 416928 AA190573 Hs. 85902 ESTs, Weakly similar to MCHU calmodulin 2. 9 430195 AW969308 Hs. 188594 ESTs 2. 9 458544 A1631036 Hs. 196843 ESTs 2. 9 440667 BE076969 Hs. 7337 hypothetical protein FU10936 2. 9 424641 AB001106 Hs. 151413 glia maturation factor, beta 2. 9 428820 AA436187 Hs. 172631 integnn, alpha M (complement component 2. 9 405403 Target Exon 2. 9 452197 AW023595 Hs. 232048 ESTs 2. 9 437357 AL359559 Hs. 331666 Homo sapiens mRNA : cDNA DKFZp76202215 (f 2. 9 423479 NM_014326 Hs. 129208 death-associated protein kinase 2 2. 9 404559 Target Exon 2. 9 406270 Target Exon 2. 9 422190 H17399 Hs. 11506 Human clone 23589 mRNA sequence 2. 9 431300 AA502346 gb : ne26b03. s1 NCI_CGAP_Co3 Homo sapiens 2. 9 420286 A1796395 Hs. 111377 ESTs 2. 9 422964 AW439476 Hs. 256895 ESTs 2. 9 431583 AL042613 Hs. 262476 S-adenosylmethioninedecarboxylase1 2. 9 428595 AB037795 Hs. 186547 KIAA1374 protein 2. 9 402198 NM_024323 : Homo sapiens hypothetical prot 2. 9 416246 U47413 Hs. 79101 cyclin G1 2. 9 427593 AK001132 Hs. 179752 HomosapienscDNAFW10270fis, cloneHE 2. 9 446351 AW444551 Hs. 35380 x 001 protein 2. 9 440432 A1239637 Hs. 202653 ESTs, Weakly similar to T14267 Xin prote 2. 9 446525 AW967069 Hs. 211556 hypotheGcalproteinMGC5487 2. 8 400965 C110021 90-: gil12737279lrenXP_0121 63. 11 2. 8 436489 AJ272269 Hs. 121429 zinc-binding protein Rbcc728 2. 8 458793 N80159 Hs. 121849 microtubule-associated proteins 1A/1B li 2. 8 406810 U82275 Hs. 94498 leukocyte immunoglobulin-like receptor, 2. 8 445577 N40696 Hs. 137064 cytoplasmic polyadenylation element bind 2. 8 428874 W32133 Hs. 194366 transthyreGn (prealbumin, amyloidosis t 2. 8 418745 AW882645 Hs. 88044 sprouty (Drosophila) homolog 1 (antagoni 2. 8 433095 AK001092 Hs. 302480 Homo sapiens cDNA FU10230 fis, clone HE 2. 8 425580 L11144 Hs. 1907 galanin 2. 8 416233 AA176633 gb : zp13g01. s1 Stratagene fetal re6na 93 2. 8 438219 A1916151 Hs. 257194 ESTs 2. 8 404661 C9000306' : gi ! 12737280trefiXP006682. 2k 2. 8 435836 AW292532 Hs. 343667 homolog of yeast long chain polyunsatura 2. 8 423665 BE167153 Hs. 24380 ESTs 2. 8 430320 BE245290 Hs. 239218 uncharacterized hypothalamus protein HCD 2. 8 401783 NM003771' : Homo sapiens keratin, hair, a 2. 8 423837 AW937063 Hs. 275150 gb : PM3-DT0037-231299-001-g11DT0037Homo 2. 8 447271 AL041747 Hs. 170261 ESTs 2. 8 438913 Al380429 Hs. 172445 ESTs 2. 8 441962 AW972542 Hs. 289008 Homo sapiens cDNA : FU21814 fis, clone H 2. 8 444385 BE278964 Hs. 11085 CGI-111 protein 2. 8 432278 AL137506 Hs. 274256 hypothetical protein FLJ23563 2. 8 415666 H72693 gb : yu03ctt. rl Soaresfetalliverspleen 2. 8 452345 M293279 Hs. 29173 hypothetical protein FLJ20515 2. 8 445898 AF070623 Hs. 13423 Homo sapiens clone 24468 mRNA sequence 2. 8 439556 A1623752 Hs. 163603 ESTs 2. 8 405474 NM 001093' : Homo sapiens acetyl-Coenzyme 2. 8 426208 A1370379 Hs. 132216 ESTs 2. 8 419461 A1452601 Hs. 288869 nuclear receptor subfamily 2, group F, m 2. 8 428501 AL041162 Hs. 98587 ESTs 2. 8 413427 U31120 Hs. 845 interleukin 13 2. 8 433109 N58907 Hs. 162430 EST 2. 8 427974 BE093023 Hs. 188767 ESTs 2. 8 455040 AW852286 gb : QVO-CT0225-100400-187-d08 CT0225 Homo 2. 8 453994 BE180964 Hs. 165590 ribosomai protein S13 2. 8 459171 AW967801 Hs. 64783 ESTs, Weakly similar to T42705 hypotheti 2. 8 404845 C22000163' : git10242166 ! gbtAAG15318. 1AF2 2. 8 408182 AA047854 gb : zf49gO4. r1 Soares eGna N2b4HR Homo 2. 8 427111 AA351026 Hs. 173594 serine (or cysteine) proteinase inhibito 2. 7 414541 BE293116 Hs. 76392 aldehyde dehydrogenase 1 family, member 2. 7 432815 Z30045 Hs. 293676 ESTs 2. 7 404036 Target Exon 2. 7 418157 W99382 Hs. 283709 lipopolysaccharide specific response-7 p 2. 7 426403 Nom000361 Hs. 2030 thrombomodulin 2. 7 439659 AW970780 Hs. 59483 Homo sapiens cDNA FLJ14471 hs, clone MA 2. 7 443932 AW888222 Hs. 9973 tensin 2. 7 444930 BE185536 Hs. 301183 molecule possessing ankyrin repeats indu 2. 7 419269 AA235838 gb : zs41b04. s1SoaresNhHMPuS1Homosapi 2. 7 416004 D11880 Hs. 299254 Homo sapiens cDNA : FLJ23597 fis, clone L 2. 7 430371 D87466 Hs. 240112 KIAA0276 protein 2. 7 449117 AW449310 Hs. 210262 ESTs, Weakly similar to HSS2_HUMAN HEPAR 2. 7 451007 H38108 Hs. 32759 ESTs 2. 7 421202 AF193339 Hs. 102506 eukaryotic translation initiation factor 2. 7 406308 NM025192 : Homo sapiens hypothetical prot 2. 7 413208 BE071799 gb : RCO-BT0522-071299-011-b10 BT0522Homo 2. 7 421420 A1024236 Hs. 123296 ESTs, WeaklysimilartoPEC1_HUMANPLATE 2. 7 445693 AW800444 Hs. 76507 LPS-induced TNF-alpha factor 2. 7

452351 AA025647 gb : ze85dO1. r1Soaresfeta) heartNbHH19W 2. 7 410538 AW753115 gb : PMO-CT0248-131099-001-h12CT0248Homo 2. 7 448072 A1459306 Hs. 24908 ESTs 2 7 420912 AW853156 Hs. 90787 ESTs 2. 7 453830 AA534296 Hs. 20953 ESTs 2. 7 457791 AW117431 Hs. 191906 ESTs 2. 7 417735 AA188175 Hs. 82506 KIAA1254 protein 2. 7 411773 NM_006799 Hs. 72026 protease, serine, 21 (testisin) 2. 7 417076 AW973454 Hs. 238442 ESTs, Moderately similar to ALULHUMAN A 2. 7 436476 AA326108 Hs. 33829 bHLH protein DEC2 2. 7 440945 AW505345 Hs. 7540 f-box and leucine-rich repeat protein 3A 2. 7 425826 U97698 mucin 6, gastric 2. 7 422795 AB033109 Hs. 120866 KIAA1283 protein 2. 7 433921 AA618174 gb : nq14K) 1. s1NaCGAPThy1Homosapiens 2. 7 414272 A1651603 Hs. 46988 ESTs Z7 418047 R37633 Hs. 4847 ESTs 2. 7 421089 AB037771 Hs. 101799 KIAA1350 protein 2. 7 419763 A1039691 Hs. 127486 ESTs 2. 7 459265 AJ003616 gb : AJ003616 Selected chromosome 21 cDNA 2. 7 410970 AW812151 gb : RC5-ST0178-081099-011-A06ST0178Homo 2. 7 401925 N98378 sialyltransferase 1 (beta-galactoside al 27 418504 BE159718 Hs. 85335 Homo sapiens mRNA ; cDNA DKFZp564D1462 (f 2. 6 433789 AA220977 gb : zrO1aO8. r1 Stratagene NT2 neuronal pr 2. 6 418308 AA215738 Hs. 182514 ESTs, WeaklysimilartoM6010X-linked 2. 6 444618 AV653785 Hs. 173334 ELL-RELATED RNA POLYMERASE II, ELONGATIO 2. 6 406299 Target Exon 2. 6 422963 M79141 Hs. 13234 ESTs 2. 6 441244 BE612935 Hs. 184052 PP1201 protein 2. 6 439954 AL046748 Hs. 6790 DnaJ (Hsp40) homolog, subfamily B, membe 2. 6 405088 Target Exon 2. 6 404741 Target Exon 2. 6 451927 AL355687 Hs. 27261 Homo sapiens mRNA full length insert cDN 2. 6 439103 AF085959 Hs. 38705 ESTs 26 437241 AL137318 Hs. 306450 Homo sapiens mRNA ; cDNA DKFZp434L171 (fr 2. 6 442379 NM 004613 Hs. 8265 transglutaminae 2 (C polypepGde, prote 2. 6 457394 M86528 Hs. 266902 neurotrophin 5 (neunotrophin 4/5) 2. 6 427229 A1799751 Hs. 5635 ESTs 2. 6 414630 BE410857 Hs. 16064 gb : 601301177F1 NIH_MGC_21 Homosapiensc 2. 6 406744 AA554082 Hs. 279860 tumor protein, translationaliy-controlle Z6 443984 A1424415 Hs. 143719 ESTs 2. 6 421221 AW276914 Hs. 326714 Homo sapiens clone IMAGE : 713177, mRNAse 2. 6 421709 AA159394 Hs. 107056 CED-6 protein 2. 6 426747 AA535210 Hs. 171995 kallikrein 3, (prostate specific antigen 2. 6 439480 AL038511 Hs. 125316 ESTs, Weakly similar to S33990 finger pr 2. 6 419567 AW339890 Hs. 128187 ESTs Z6 421922 AW295043 Hs. 109590 genethonin 1 2. 6 421859 AA356620 Hs. 108947 KIAA0050gene product 2. 6 431441 U81961 Hs. 2794 sodium channel, nonvoltage-gated I alpha 2. 6 444843 AA400172 gb : zu69eO1. r1SoarestestisNHT Homo sap 2. 6 416729 U46165 Hs. 1027 Ras-related associated with diabetes 2. 6 439238 N47305 Hs. 302161 ESTs 2. 6 439183 AW970600 Hs. 303261 ESTs 2. 6 408739 W01556 Hs. 238797 ESTs, Moderately similar to 138022 hypot 2. 6 412061 AA833763 Hs. 330211 ESTs 2. 6 432114 AL036021 Hs. 8934 ESTs 2. 6 425337 AA355442 Hs. 169054 ESTs 2. 6 424299 AK000377 Hs. 82294 homolog of mouse C2PA 2. 6 448871 BE616709 Hs. 159265 kruppel-related zinc finger protein hcKr 2. 6 414516 Api307802 Hs. 135560 ESTs, Weakly similar to T43458 hypotheU 2. 6 456235 AA203637 gb : zx58b12. ri Soaes_fetal_liver_spleen_ 2. 6 410429 AA310600 Hs. 63657 peptide : N-glycanase similar to yeast PNG 2. 6 449251 AW151660 Hs. 31444 ESTs 2. 6 436546 AW023329 Hs. 132743 ESTs 2. 6 450546 AA010200 Hs. 175551 ESTs 2. 6 437255 R58970 Hs. 9887 ESTs 2. 6 409041 AB033025 Hs. 50081 Hypothetical protein, XP 051860 (KIAAi 19 2. 6 427983 M17706 Hs. 2233 colony simulating factor 3 (granulocyte 2. 5 413341 H78472 Hs. 191325 ESTs, Weakly similar to T 18967 hypotheG 2. 5 423763 R98203 Hs. 132724 nuclear transcription factor Y, alpha 2. 5 413282 BE078159 gb : CMO-BT061S140200-175-e06 BT0615 Homo 2. 5 415590 T74068 Hs. 170081 gb : yc81fO7. rl Soares infant brån lNIB H 2. 5 406215 Target Exon 2. 5 453938 AF082569 Hs. 36794 D-type cyclin-interacting protein 1 2. 5 424310 AA338648 Hs. 50334 testes development-elated NYD-SP22 2. 5 442097 AW015799 Hs. 128474 ESTs 2. 5 456650 AA620501 Hs. 106773 ESTs, Weakly similar to T42689 hypotheti 2. 5 413231 D87461 Hs. 75244 BCL2-like 2 2. 5 457297 AW968188 gb : EST380383 MAGE resequences, MAGJ Homo 2. 5 444942 AW293458 Hs. 283807 chromosome 11 open reading frame 16 2. 5 425764 AW996009 Hs. 112572 Homo sapiens cDNA FW14130 fis, cione MA 2. 5 435712 AA694607 Hs. 176956 ESTs 2. 5 436624 T64297 fatty acid binding protein 1, liver 2. 5 443155 R54485 Hs. 23772 ESTs 2. 5

425907 AA365752 Hs. 155965 ESTs 2. 5 414759 AW295157 Hs. 47587 ESTs 2. 5 414699 Api815523 Hs. 76930 synuclein, alpha (non A4 component of am 2. 5 411426 BE141714 gb : OV0-HT0101-061099-032-c04 HT0101 Homo 2. 5 404492 C8000067' : gill0432400lembCAC10290. 11 (A 2. 5 425153 AW023193 Hs. 27046 ESTs 2. 5 426372 BE304680 Hs. 169531 DEAD/H (Asp-Gtu-Aia-Asp/His) box polypep 2. 5 434803 AW974640 Hs. 303413 ESTs 2. 5 425694 U51333 Hs. 159237 hexokinae3 (whitecell) 2. 5 433069 X76732 Hs. 3164 nucleobindin 2 2. 5 428054 Api948688 Hs. 266619 ESTs 2. 5 424823 NM_006226 Hs. 153322 phospholipase C, epsilon 2. 5 456972 A1054347 Hs. 2017 ribosome protein L38 2. 5 431405 Al470895 Hs. 334895 dbosomal protein L10a 2. 5 427982 NM_016156 Hs. 181326 KIAA1073 protein 2. 5 412831 AA121352 Hs. 143314 ESTs 2. 5 437114 AA836641 Hs. 163085 ESTs 2. 5 426157 AA370977 Hs. 345728 STAT induced STAT inhibitor 3 2. 5 448786 BE048842 Hs. 179075 HomosapienscDNAFW11881fis, doneHE Z5 432251 AW972983 Hs. 232165 potycythemia nubra vera 1 ; cell surfæ 2. 5 449239 T24653 Hs. 23360 likely ortholog of yeast ARV1 2. 5 453572 AA382590 Hs. 46366 KiM0948 protein 2. 5 TABLE 23B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408182 104479 1 AA047854 AA057506 AA053841 409856 1156268_1 AW502082 AW502979 AW502807 AW501876 410509 1206699_1 AW640743AW752404H43469 410538 1207341_1 AW753115AW753113R45779 410786 1221063 1 AW803340 AW803280 AW803275 AW803415 AW803343 AW803422 410970 1228131_1 AW812151 AW812186AW812166 411426 1245515_1 BE141714AW845993AW845989 411906 12652041 AW875765H50294AW875444 412636 13165 NM_004415 AL031058 M77830 BE149760AW752599AW848723 AW376697 AW376817 AW376699AW848371 AW376782 AW848789 AW361413 AW849074 AW997139 AW799304 AW799309 BE077020 BE077017 BE185187AW997196BE156621 BE179915 6E006561 BE143155AW890985 BE002107 AW103521 AA857316 AW383133 BE011378 AW170253 BE185750 AW886475 BE160433 J05211 BE082576 BE082584 BE004047 AW607238 AW377700 AW377699 BE082526 BE082505 BE082507 BE082514 AW178000 AW177933 Al905935 AW747877 AW748114 BE148516 AW265328 AW847678 AW847688 AW365151 AW365148 AW365153 AW365156 AW365175 AW365157 AW365154 AW068840 BE005272 AW365145 BE001925 BE182166 BE144243 BE001923 Al951766 Al434518 BE184920 BE184933 Al284090 BE184941 AW804674 BE184924 C04715 W39488 AW995615 BE184948 BE159646 AW606653 AA099891 AA131128 AA337270 AA340777 AW384371 AA852212 R58704 AW366566 AW364859 AA025851 AA025852 AA455100 AA719958 AW352220 AW996245 BE165351 BE073467 AA377127 AW890264 AW609750 AW391912 AW849690 T87267 AW853812 AA852213 W74149 BE009090 AA056401 H91011 AW368529 AW390272 C18467 AW674920 N57176 AA026480 AW576767 H93284 AA026863 AW177787 AA026654 AW177786 BE092134 BE092137 BE092136 AW177784 A1022862 BE091653 AW376811 AW848592 AA040018 BE185331 BE182164 AA368564 AW951576 T29918 AA131077 W95048 W25458 AW205789 H90899 N29754 W32490 R20904 BEi67181 BE167165 N84767 H27408 H30146 Ai190590 C03378 A1554403 A1205263 AA128470 A1392926 AF139065 AW370813 AW370827 AW798417 AW798780 AW798883 AW798569 R33557 AA149190 C03029 AW177783 AA088866 AW370829 AA247685 BE002273 AI760816 AI439101 AW879451 A1700963 M451923AI340326 Al590975 T48793 At568096 Ai142882 AA039975 Ai470146 AA946936 BE067737 BE067786 W19287 AA644381 AA702424 AI417612 AI306554 AI686869 AI568892 AW 190555 A1571075 AI220573 AA056527 AI471874 AI304772 AW517828 Al915596 Al627383 A1270345 AW021347 AW166807 AW105614 A1346078 AA552300 W95070 AI494069 AI911702 AA149191 AA026864 AI830049 AI887258 AW780435 A1910434 A1819984 A1858282 A1078449 A1025932 A1860584 A1635878 AA026047 AA703232 D12062 AW192085 AA658154 AW514597 AW591892 T87181 AA782066 AW243815 AW150038 AW268383 AW004633 At927207 AA782109 AW473233 Ai804485 AW169216 AI572669 AA602182 AW015480 AW771865 Ai270027 AA961816 AA283207 A1076962 A1498487 A) 348053 Ai783914 H44405 AW799118 AA128330 AA515500 AA918281 W02156 A1905927 AA022701 W38382 R20795 T77861 AW860878 413208 1353610 1 BE071799 BE071804 BE071798 413266 1356260 1 BE300352 BE299274 BE075351 BE297444 413282 1358147-1 BE078159 BE078276 BE078163 BE078277 BE078279 BE078158 413493 1373555_1 BE144444 BE144430 415606 1540470_1 W70022R35201 F12763T74725H63435Z45782H61126 415666 1543492 1 H72693 R08673 H72694 F20990 R08580 416233 158010 1 AA176633 AW961842 AA309418 4t9269 183444_1 AA235838 BE180775 419386 184356 1 AA236867 AA237066 AA354236 AW957759 H08961 425826 25682 1 U97698 AW815264 AI791966 AI732669 AA588236 AI521662 AI804760 AI955717 AW292169 AI468227 AI420483 AA603459 AI868225 AI919551 431300 331217_1 M502346 BE159863 433789 37421 1 AA220977 AF091029 AA701227 433921 377350J AA618174Ai114549R36464R36465 436624 4237_5 T64297 AA894931 NM001443 M10050 AW843109 Ai698516 T53219 T48785 T64166 AA706930 R29613 T55913 T56518 T64679 R29666 M10617 A1768596 AA101894 W90338 Ai742193 AW752206 AA099433 T53220 AW082135 AW272775 T29562 T55862 Al343047 Al345671 T68235 T68121 AW842284 444843 62260 t AA400172 AA400146 AV651691 445797 650943-1 A1253414 A1366014 R34822 447135 709631 T58148AW516579AW059603 449901 818599 1 A1674072 BE268487 450928 851593 1 A1744417 R91614 H77365 452351 91233 1 AA025647 R45716 AW753786 455040 12500281 AW852286AW851934AW852096AW852274 456235 168686 1 AA203637 AA832266 H67452 457297 3137641 AW968188AA468196AA468269AA468298 459265 966590_1 AJ003616 AJ003654 AJ003617

TABLE 23C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'efers to the publication entitled'The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 400965 7770576 Minus 173043-173564 401507 7534110 Plus 7105S71259 401600 4388746 Minus 27363-27518, 28727-28891, 29526-29731 401783 7249190 Pius 139369-139827, 140509-140591, 140834-140990, 14149&141657, 141757-141882, 142063-142283 401925 3892083 Minus 138252-138469, 140239-140364, 140437-140598, 141037-141193. 141925-142007. 142787-143230 402198 8576116 Plus 79041-79191 402364 9454515 Minus 5498355240, 56507-56785. 56982-57365 402429 9796372 Minus 57622-57793. 59282-59402, 59624-59827 403442 7210003 Plus 174560-175270 403469 9929739 Minus 4831-7707 403488 9966615 Minus 12450-12753 403512 7656757 Minus 114487-114610 403890 7710561 Plus 83165-83350 404036 8567760 Minus 65247-67529, 112537-114863 404091 7684554 Minus 82121-83229 404333 9802821 Minus 137948-138024, 138111-138300 404492 8123400 Minus 138612-138803 404559 8748893 Minus 73499-73651, 89575-89739 404606 9212936 Minus 22310-23269 404661 9797073 Plus 33374-33675, 33769-34008 404741 8574139 Plus 143025-143467 404845 7958980 Minus 47174-47326, 52928-53146, 53312-53602 405088 8072518 Minus 115690-117621 405354 2642452 Plus 52213-53089 405403 6850244 Minus 37491-37670, 40951-41031 405474 8439781 Plus 172005-172175 405586 5002511 Plus 38810-39017 405670 4662655 Plus 96543-96870 405674 4589984 Plus 68302-68429 406085 9123888 Plus 18665-18843 406215 7342161 Plus 310-432 406270 7534217 Pius 1313&13591 406299 5686278 Minus 35655-36119 406308 9211532 Plus 358408-358651 TABLE 24A : ABOUT 1260 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES Table 24A lists about 1260 genes up-regulated in glioblastoma compared to normal adult tissues. These were selected from 59680 probesets on the AffymeUix/Eos Hu03 GeneChip array such that the ratio of'average'glioblastoma to'average'normal adult tissues was greater than or equal to 2. 5. The'average'glioblastoma level was set to the 75^ percenGle amongst various glioblastoma tumors. The'average'normal adult Gssue level was set to the 85' percen6le amongst various non-malignant tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10^ percenGle value amongst the various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of 75 percentile tumor to 85^ pencentile nommal body tissue Pkey ExAccn UnigenelD Unigene Title R1 431917 D16181 Hs. 2868 peripheral myelin protein 2 75. 2 427343 A1880044 Hs. 176977 protein kinase C binding protein 2 74. 6 455601 A1368680 Hs. 816 SRY (sex determining region Y)-box 2 74. 2 428321 A1699994 Hs. 2868 peripheral myelin protein 2 71. 6 412719 AW016610 Hs. 129911 ESTs 70. 7 449494 AW237014 Hs. 315369 Homo sapiens cDNA : FLJ23075 fis, clone L 66. 3 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 64. 3 413472 BE242870 Hs. 75379 solute carrier family 1 (glial high affi 60. 1 456759 BE259150 Hs. 127792 delta (Drosophila)-like3 52. 3 435147 AL133731 Hs. 4774 HomosapiensmRNA ; cDNADKFZp761C1712 (i 46. 7 425842 A1587490 Hs. 159623 NK-2 (Drosophila) homolog B 40. 1 412733 AA984472 Hs. 74554 KIAA0080 protein 39. 0 418375 NM 003081 Hs. 84389 synaptosomal-associated protein, 25kD 38. 7 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 37. 2 423849 AL157425 Hs. 133315 Homo sapiens mRNA ; cDNA DKFZp761J1324 (f 36. 8 413333 M74028 Hs. 75297 fibroblast growth factor 1 (acidic) 32. 8 416829 AB013805 Hs. 80220 catenin (cadherin-associated protein), d 31. 8 431941 AK000106 Hs. 272227 Homo sapiens cDNA FW20099 hs, clone CO 31. 8 436878 BE465204 Hs. 47448 ESTs 31. 4 426325 D28114 Hs. 169309 myelin-associated oligodendrocyte basic 30. 9 425057 AA826434 Hs. 1619 achaete-scute complex (Drosophila) homol 30. 4 446711 AF169692 Hs. 12450 protocadherin9 30. 2 439415 F05538 Hs. 12825 ESTs 28. 3 430838 N46664 Hs. 169395 hypothetical protein FLJ12015 26. 9 429466 M85835 Hs. 12827 ESTs 25. 9

447004 AW296968 Hs. 157539 ESTs 25. 3 424581 M62062 Hs. 150917 catenin (cadhedn-associated protein), a 24. 8 452744 A1267652 Hs. 30504 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 24. 8 441285 NM002374 Hs. 167 microtubule-associated protein 2 24. 3 453642 A1370936 Hs. 34074 dipeptidylpeptidase ! 24. 3 424140 Z48051 Hs. 141308 myelin oligodendrocyte glycoprotein 24. 2 450133 AW969769 Hs. 105201 ESTs 24. 2 408562 AI436323 Hs. 31141 Homo sapiens mRNA for KIAA1568 protein, 23. 3 448672 A1955511 Hs. 225106 ESTs 22. 7 435708 A1362949 Hs. 75169 ESTs 22. 0 407034 U84540 gb : Human dystrobrevin isofomm DTN-3 (DTN 21. 9 407168 R45175 Hs. 117183 ESTs 21. 7 431019 NM 005249 Hs. 2714 forkhead box G1B 21. 5 409049 A1423132 Hs. 146343 ESTs 21. 4 433896 AW294729 Hs. 274461 ESTs 21. 1 445041 T64183 Hs. 282982 solute carrier 21. 0 418738 AW388633 Hs. 6682 sofute carrier family 7, (cationic amino 20. 4 444378 R41339 Hs. 12569 ESTs 20. 0 411305 BE241596 Hs. 69547 myelin basic protein 19. 9 437414 AW894071 Hs. 48448 hypoGheUcal protein DKFZpS47C176 19. 8 441016 AW138653 Hs. 25845 ESTs 19. 6 440435 AL042201 Hs. 21273 transcriptionfætorNYD-sp10 18. 5 438209 AL120659 Hs. 6111 aryl-hydrocarbonreceptornucleartransl 18. 4 452461 N78223 Hs. 108106 transcription factor 18. 1 409395 U46745 Hs. 54435 dystrobrevin, alpha 18. 1 417183 R52089 Hs. 172717 ESTs 18. 0 409638 AW450420 Hs. 21335 ESTs 18. 0 428392 H10233 Hs. 2265 secretory granule, neuroendocrineprotei 18. 0 449611 A1970394 Hs. 197075 ESTs 17. 0 446692 Z44514 Hs. 156829 Homo sapiens mRNA for KIAAI 763 protein, 16. 9 425088 AA663372 Hs. 169395 hypothetical protein FW12015 16. 9 444471 AB020684 Hs. 11217 KIAA0877 protein 16. 8 421659 NM014459 Hs. 106511 protocadherin 17 16. 7 431725 X65724 Hs. 2839 Nome disease (pseudoglioma) 16. 6 429276 AF056085 Hs. 198612 G protein-coupled receptor 51 16. 6 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible, 16. 5 441440 A1807981 Hs. 30495 ESTs 15. 7 449433 A1672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 15. 7 421264 AL039123 Hs. 103042 microtubule-associated protein 1B 15. 5 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 15. 3 413597 AW302885 Hs. 117183 ESTs 15. 1 424945 A1221919 Hs. 173438 hypothetical protein FU10582 14. 9 447414 D82343 Hs. 18551 neuroblastoma (nerve tissue) protein 14. 9 426269 H15302 Hs. 168950 HomosapiensmRNA ; cDNADKFZpS66A1046 (f 14. 8 416857 AA188775 Hs. 292453 ESTs 14. 7 419721 NM001650 Hs. 288650 aquaporin 4 14. 6 411078 A1222020 Hs. 182364 CocoaCrisp 14. 4 453924 R49295 Hs. 24886 ESTs 14. 4 409389 AB007979 Hs. 301281 Homo sapiens mRNA, chromosome 1 specific 14. 3 430130 AL137311 Hs. 234074 HomosapiensmRNA ; cDNADKFZp761G02121 (14. 1 410909 AW898161 Hs. 53112 ESTs, Moderately similar to ALU8 HUMAN A 14. 0 412266 N59006 Hs. 26133 ESTs 14. 0 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) 14. 0 424790 AL119344 Hs. 13326 ESTs, Weakly similar to 2004399A chromos 14. 0 439239 A1031540 Hs. 235331 ESTs 14. 0 441497 R51064 Hs. 23172 ESTs 14. 0 445495 BE622641 Hs. 38489 ESTs, Weakly similar to 138022 hypotheG 14. 0 414245 BE148072 Hs. 75850 WAS protein family, member 1 13. 7 429900 AA460421 Hs. 30875 ESTs 13. 6 448595 AB014544 Hs. 21572 KIAA0644 gene product 13. 6 449605 AW138581 Hs. 198416 ESTs 13. 6 452526 W38537 Hs. 280740 hypothetical protein MGC3040 13. 6 420547 AF155140 Hs. 98738 gonadotropin-regutated testicular RNA he 13. 3 441350 AB020690 Hs. 7782 paraneopiastic antigen MA2 13. 3 420077 AW512260 Hs. 87767 ESTs 13. 2 424120 T80579 Hs. 290270 ESTs 13. 2 456965 AW131888 Hs. 172792 ESTs, Weakly similar to hypothetical pro 13. 2 423361 AW170055 Hs. 47628 ESTs 13. 1 428409 AW117207 Hs. 98523 ESTs 12. 9 417160 N76497 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 12. 6 451621 Al879148 Hs. 26770 fatty acid binding protein 7, brain 12. 5 411379 A1816344 Hs. 12554 ESTs, WeaklysimilartoNPL4_HUMANNUCLE 12. 5 436954 AA740151 Hs. 130425 ESTs 12. 4 430691 C14187 Hs. 103538 ESTs 12. 4 433551 A1985544 Hs. 12450 protocadherin 9 12. 4 422544 AB018259 Hs. 118140 KIAA0716 gene product 12. 2 427540 R12014 Hs. 20976 ESTs 12. 1 435624 AF218942 Hs. 24889 formin 2 12. 1 415849 R20529 Hs. 6806 ESTs 12. 1 428845 AL157579 Hs. 153610 KIAA0751 gene product 11. 9 442671 A1005668 Hs. 134779 EST 11. 9 444396 T65213 Hs. 4257 ESTs 11. 8 452752 AW044058 Hs. 33578 KIAA0820 protein 11. 8

425523 AB007948 Hs. 158244 KIAA0479 protein 11. 8 416072 AL110370 Hs. 79000 growth associated protein 43 11. 7 440184 AB002297 Hs. 7022 dedicatorofcyto-kinesis3 11. 7 428976 AL037824 Hs. 194695 ras homolog gene family, member 1 11. 6 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 11. 6 448299 AA497044 Hs. 20887 hypothetical protein FLJ10392 11. 6 414214 D49958 Hs. 75819 glycoprotein M6A 11. 5 428982 Nom005097 Hs. 194704 leucine-rich, gliomainæbvated1 11, 5 405238 11. 4 420362 U79734 Hs. 97206 huntingtin interacting protein 1 11. 4 422980 N46569 Hs. 76722 CCAAT/enhancer binding protein (GEBP), 11. 4 424918 R13982 Hs. 169309 myelin-associated oligodendrocyte basic 11. 4 434277 X77748 Hs. 3786 glutamate receptor, metabotropic 3 11. 4 451952 AL120173 Hs. 301663 ESTs 11. 3 408829 NM_006042 Hs. 48384 heparan sulfate (glucosamine) 3-0-sulfot 11. 3 424278 AK000723 Hs. 144517 hypothetical protein FLJ20716 11. 3 429418 A1381028 Hs. 118769 ESTs 11. 3 429918 AW873986 Hs. 119383 ESTs 11. 3 443912 R37257 Hs. 184780 ESTs 11. 3 448743 AB032962 Hs. 21896 KIAA1136 protein 11. 3 420092 AA814043 Hs. 88045 ESTs 11. 2 408081 AW451597 Hs. 167409 ESTs 11. 2 411642 NM_014932 Hs. 71132 neurotigint 10. 9 415170 R44386 Hs. 164578 ESTs 10. 9 426320 W47595 Hs. 169300 transforming growth factor, beta 2 10. 8 450568 AL050078 Hs. 25159 Homo sapiens cDNA FLJ10784 fis, clone NT 10. 8 425799 T08133 Hs. 182906 Homo sapiens mRNA for KIAA1872 protein, 10. 8 423853 AB011537 Hs. 133466 slit (Drosophila) homolog 1 10. 7 400293 N51002 Hs. 306480 HomosapiensmRNA ; cDNADKFZp761E2112 (f 10. 7 447773 A1423930 Hs. 36790 ESTs, Weakly similar to putative p150 [H 10. 7 448321 NM_005883 Hs. 20912 adenomatous polyposis coli like 10. 5 448533 AL119710 Hs. 21365 nucleosomeassemblyprotein 1-like3 10. 5 440684 A1253123 Hs. 127356 ESTs, Highly similar to S21424 nesfin [H 10. 3 444017 U04840 Hs. 214 neuro-oncological ventral antigen 1 10. 3 438380 T06430 Hs. 6194 chondroi6n sulfate proteoglycan BEHAB/b 10. 3 440471 AA886146 Hs. 307944 ESTs 10. 2 413063 AL035737 Hs. 75184 chitinase3-tike1 (cartitageg) ycoprote 10. 1 439978 BE139460 Hs. 124673 Homo sapiens cDNA FW11477 fis, clone HE 10. 1 448902 Z45998 Hs. 22543 Homo sapiens mRNA ; cDNA DKFZp76111912 (f 10. 1 424932 R14070 Hs. 315369 Homo sapiens cDNA : FU23075 fis, clone L 9. 9 431721 AB032996 Hs. 268044 KIAA1170 protein 9. 9 419088 A1538323 Hs. 52620 integrin, beta 8 9. 8 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 9. 8 436511 AA721252 Hs. 291502 ESTs 9. 8 414696 AF002020 Hs. 76918 Niemann-Pick disease, typed 9. 7 449539 W80363 Hs. 58446 ESTs 9. 7 412959 D87458 Hs. 75090 KIAA0282 protein 9. 6 412811 H06382 Hs. 21400 ESTs 9. 6 449300 A1656959 Hs. 222165 ESTs 9. 6 426344 H41821 Hs. 322469 transcriptionatactivatorofthec-fosp 9. 5 419271 N34901 Hs. 238532 ESTs 9. 5 419078 M93119 Hs. 89584 insulinoma-asociated 1 9. 4 451516 A1800515 Hs. 12024 ESTs 9. 4 422656 A1870435 Hs. 1569 LIM homeobox protein 2 9. 3 449318 AW236021 Hs. 78531 Homo sapiens, Similar to RIKEN cDNA 5730 9. 3 414175 At308876 Hs. 103849 hypothetical protein DKFZp761D112 9. 3 415279 F04237 Hs. 1447 glial fibrillary acidic protein 9. 2 428784 Y12851 Hs. 193470 purinergic receptor P2X, ligand-gated io 9. 2 429903 AL134197 Hs. 93597 cyclin-dependent kinase 5, regulatory su 9. 2 424641 AB001106 Hs. 151413 gtiamaturationfactor. beta 9. 1 417435 Nom 005181 Hs. 82129 carbonic anhydrase III, muscle specific 9. 1 449448 D60730 Hs. 57471 ESTs 9. 1 408508 Api806109 Hs. 135736 KIAA1580 protein 9. 0 452785 AL359942 Hs. 296434 erythroid differentiation and denucleati 9. 0 448986 H42169 Hs. 18653 hypothe6cal protein FLJ14627 8. 9 447072 D61594 Hs. 17279 qrosylpnotein sutfotransferae 1 8. 9 433800 A1034361 Hs. 135150 lung type-tee cell membrane-associated gly 8. 9 408926 AF217525 Hs. 49002 Down syndrome cell adhesion molecule 8. 8 449625 NM_014253 Hs. 23796 odz (odd OzAen-m, Drosophila) homolog 1 8. 8 400292 AA250737 Hs. 72472 ESTs 8. 7 417404 NM 007350 Hs. 82101 pleckshin homology-like domain, family 8. 7 420345 AW295230 Hs. 25231 ESTs 8. 7 429927 NM001115 Hs. 2522 adenylate cyclase 8 (brain) 8. 7 437528 N59646 Hs. 169745 crumbs (Drosophila} homolog 1 8. 7 440152 AB002376 Hs. 7006 KIAA0378 protein 8. 7 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 8. 6 400780 8. 6 434891 AA814309 Hs. 123583 ESTs 8. 6 449277 AA001064 Hs. 172976 ESTs 8. 6 415709 AA649850 Hs. 278558 ESTs 8. 5 439947 A8006627 Hs. 6788 astrotactin 8. 5 447197 R36075 gb : yh88bO1. s1 Soares placenta Nb2HP Homo 8. 5 433042 AW193534 Hs. 281895 HomosapienscDNAFW11660hs, cloneHE 8. 4

416370 N90470 Hs. 203697 ESTs, Weakly similar to 138022 hypothefi 8. 4 452786 R61362 Hs. 106642 ESTs. Weakly similar to T09052 hypotheti 8. 4 415796 R87548 Hs. 78854 ATPase, Na+/Ktransporting, beta2poly 8. 3 426271 AF026547 Hs. 169047 chondroitin sulfate proteoglycan 3 (neur 8. 3 408947 AL080093 Hs. 49117 Homo sapiens mRNA ; cDNA DKFZp564N1662 (f 8. 3 419863 AW952691 Hs. 93485 Homo sapiens mRNA ; cDNADKFZp761D191 (fr 8. 3 433447 U29195 Hs. 3281 neuronal pentraxin 11 8. 3 431467 N71831 Hs. 256398 Homo sapiens mRNA ; cONA DKFZp434E0528 (f 8. 3 409327 L41162 Hs. 53563 collagen, type IX, alpha 3 8. 3 414300 A1304870 Hs. 188680 ESTs 8. 2 407728 AW071502 Hs. 175931 ESTs 8. 2 422798 R92347 Hs. 34574 ESTs, Weakly similar to ALU1HUMANALUS 8. 2 419704 AA429104 Hs. 45057 ESTs 8. 2 429007 D80642 gb : HUM092E09B Human fetal brain (TFujiwa 8. 1 442710 A1015631 Hs. 23210 ESTs 8. 1 425048 H05468 Hs. 164502 ESTs 8. 1 429149 AW193360 Hs. 197962 ESTs, Weakly similar to 138022 hypotheu 8, 0 445740 T78281 Hs. 13226 Homo sapiens done 25181 mRNA sequence 8. 0 418771 AA807881 Hs. 25329 ESTs 7. 9 422728 AW937826 Hs. 103262 ESTs, Weakly similar to ZN91 HUMAN ZINC 7. 9 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 7. 9 448408 AA322866 Hs. 21107 neuroligin 7. 9 455364 H72176 Hs. 4273 hypothetical protein FU 13159 7. 9 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponGn, 7. 9 435501 AW051819 Hs. 129908 KIAA0591 protein 7. 8 423600 A1633559 Hs. 310359 ESTs 7. 8 450625 AW970107 gb : EST382188 MAGE resequences, MAGK Homo 7. 8 415314 N88802 Hs. 5422 glycoprotein M6B 7. 7 420036 R60336 Hs. 52792 Homo sapiens mRNA ; cDNA DKFZp58611823 (f 7. 7 427687 AW003867 Hs. 1570 histamine receptor H1 7. 7 449328 Al962493 Hs. 197647 ESTs 7. 7 419249 X14767 Hs. 89768 gamma-aminobutyric acid (GABA) A recepto 7. 7 407896 D76435 Hs. 41154 Zic family member 1 (odd-paired Drosophi 7. 7 419103 Z40229 Hs. 96423 hypothetical protein FLJ23033 7. 6 438779 NM 003787 Hs. 6414 nucleolar protein 4 7. 6 433532 AW975367 gb : EST387475 MAGE resequences, MAGN Homo 7. 6 448555 A1536697 Hs. 159863 ESTs 7. 5 439662 H97552 Hs. 269060 ESTs 7. 5 448543 AW897741 Hs. 21380 Homo sapiens mRNA ; cDNADKFZp586P1124 (f 7. 5 410099 AA081630 Hs. 169387 KIAA0036 gene product 7. 5 431592 R69016 Hs. 213194 hypothetical protein MGC10895 7. 4 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 7. 4 405819 7. 4 407886 AW969688 Hs. 100826 ESTs 7. 4 437416 AL359605 Hs. 283851 Homo sapiens mRNA ; cDNA DKFZp547G036 (fr 7. 4 437698 R61837 Hs. 7990 ESTs, Moderately similar to 184505 calci 7. 4 408604 D51408 Hs. 21925 ESTs 7. 4 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 7. 3 447499 AW262580 Hs. 147674 protocadherin beta 16 7. 3 454036 AA374756 Hs. 93560 Homo sapiens mRNA for KIAA1771 protein, 7. 3 409746 NM004794 Hs. 56294 RAB33A, member RAS oncogene family 7. 2 410037 AB020725 Hs. 58009 KIAA0918 protein 7. 2 419318 AW969742 Hs. 291005 ESTs 7. 2 424051 AL110203 Hs. 138411 HomosapiensmRNA ; cDNADKFZpS86 ; 1922 (f 7. 2 442026 A1243749 Hs. 8074 brain-specific angiogenesis inhibitor 3 7. 2 448243 AW369771 Hs. 52620 integrin, beta 8 7. 2 436281 AW411194 Hs. 85195 myeloid leukemia factor 1 7. 2 426429 X73114 Hs. 169849 myosin-binding protein C, slow-type 7. 2 407182 AA312551 Hs. 230157 ESTs 7. 1 415293 R49462 Hs. 106541 ESTs 7. 1 422764 Api767727 Hs. 47522 ESTs 7. 1 451592 A1805416 Hs. 213897 ESTs 7. 1 429469 M64590 Hs. 27 gtycinedehydrogenasefdecarboxyiating : 7. 0 415734 NM014747 Hs. 78748 KIAA0237 gene product 7. 0 434149 Z43829 Hs. 19574 hypothetical protein MGC5469 7. 0 436726 AA324975 Hs. 128993 ESTs, Weakly similar to T00079 hypotheti 7. 0 417632 R20855 Hs. 5422 glycoprotein M6B 7. 0 422421 AA325138 Hs. 235873 hypothetical protein FLJ22672 6. 9 435267 N23797 Hs. two114 ESTs 6. 9 437117 AL049256 Hs. 122593 ESTs 6. 9 445523 Z30118 Hs. 293788 ESTs, Moderately similar to unnamed prot 6. 9 445900 AF070526 Hs. 13429 Homo sapiens clone 24787 mRNA sequence 6. 9 445745 AB007924 Hs. 13245 KIAA0455 gene product 6. 9 424085 NM 002914 Hs. 139226 eplicationfætorC (ætivator1) 2 (40 6. 9 428588 F12101 Hs. 185701 HomosapiensmRNAfulllengthinsertcDN 6. 8 421723 AA620400 Hs. 300717 sodium channel, voltage-gated, type 111, 6. 8 447342 A1199268 Hs. 19322 Homosapiens, SimilartoRIKENcDNA2010 6. 7 443297 A1049864 Hs. 133029 ESTs 6. 7 443992 AW022228 Hs. 322922 ESTs 6. 7 453096 AW294631 Hs. 11325 ESTs 6. 7 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 6. 7 443761 A1525743 Hs. 160603 ESTs 6. 6 429609 AF002246 Hs. 210863 cell adhesion molecule with homology to 6. 6

435056 AW023337 Hs. 5422 glycoprotein M6B 6. 5 453431 AF094754 Hs. 32973 glycine receptor, beta 6. 5 444190 Api878918 Hs. 10526 cysteine and glycine. rich protein 2 6. 5 418110 R43523 Hs. 217754 hypotheticalprotein FLJ22202 6. 5 413988 M81883 Hs. 324784 gtutamate decarboxylase 1 (brain, 67kD) 6. 5 420805 L10333 Hs. 99947 eticulon 1 6. 4 429125 AA446854 Hs. 271004 ESTs, Weakly similar to 138022 hypotheb 6. 4 435256 AF193766 Hs. 13872 cytokine-like protein C17 6. 4 407866 AW088232 Hs. 89506 paired box gene 6 (aniridia, keratins) 6. 3 440700 AW952281 Hs. 296184 guanine nucleotide binding protein (G pr 6. 3 427701 AA411101 Hs. 243886 nuclear autoantigenic sperm protein (his 6. 3 422949 AA319435 gb : EST21657 Adrenal gland tumor Homo sap 6. 2 445102 AW204610 Hs. 22270 ESTs 6. 2 452401 NM_007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 6. 2 435538 AB011540 Hs. 4930 low density lipoprotein receptor-related 6. 2 410102 AW248508 Hs. 279727 Homo sapiens cDNA FW 14035 fis, cone HE 6. 2 416871 H98716 gb : yx13dO8. s1 Soaes melanocyte 2NbHM Ho 6. 1 416702 AA186428 Hs. 85591 ESTs 6. 1 419347 C15944 Hs. 90005 superiorcervical ganglia, neural specifi 6. 1 424997 AL138167 Hs. 96920 ESTs 6. 1 438660 U95740 Hs. 6349 Homo sapiens, clone IMAGE : 3010666, mRNA, 6. 1 453649 Y07494 Hs. 34114 ATPase, Nal/K : transporGng, alpha2 (+) 6. 1 449444 AW818436 Hs. 23590 solutecarierfamily16 (monocarboxylic 6. 1 414117 W88559 Hs. 1787 proteoiipidpstein1 (Pelizæus-Merzbæ 6. 0 425517 AF121179 gb : AF121 179 Homo sapiens liver (Chang L-6. 0 427457 AW779105 Hs. 164682 ESTs 6. 0 437034 AA742643 gb : ny91c01. s1 NO_CGAP_GCB1 Homosapiens 6. 0 444170 AW613879 Hs. 102408 ESTs 6. 0 457183 H91882 Hs. 118569 Dvi-bindingproteinlDAX (inhibiGonof 6. 0 448999 AF179274 Hs. 22791 transmembrane protein with EGF-like and 6. 0 454048 H05626 Hs. 6921 ESTs 6. 0 439772 AL365406 Hs. 10268 Homo sapiens mRNA hull length insert cDN 5. 9 448944 AB014605 Hs. 22599 atrophin-1 interacting protein 1 ; activi 5. 9 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 5. 9 415486 H12214 Hs. 13284 ESTs, Weakly similar to 2109260A B cell 5. 9 438993 AA828995 gb : od77bO8. s1 CGAPOv2 Homo sapiens 5. 9 447350 A1375572 Hs. 172634 ESTs 5. 9 451783 R42554 Hs. 210862 T-box, brain, 1 5. 9 447101 N72185 Hs. 44189 ESTs 5. 9 440492 R39127 Hs. 21433 hypothetical protein DKFZp547J036 5. 9 440274 R24595 Hs. 7122 scrapie responsive protein 1 5. 9 438461 AW075485 Hs. 286049 phosphoserineaminotransferase 5. 9 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 5. 8 437036 A1571514 Hs. 133022 ESTs 5. 7 412225 AW902042 gb : QVO-NN1022-170400-193-cO2 NN1022 Homo 5. 7 426342 AF093419 Hs. 169378 mulGplePDZdomainprotein 5. 7 444218 AF070641 Hs. 10684 Homosapiensclone24421mRNAsequence 5. 7 445828 F05802 Hs. 81907 ESTs 5. 7 447198 D61523 Hs. 283435 ESTs 5. 7 427897 NM 017413 Hs. 303084 apelin ; pepGdeligandforAPJreceptor 5. 7 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 5. 7 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 5. 6 412155 R38167 Hs. 12449 Homo sapiens transmembrane protein HTMP1 5. 6 435718 R06569 Hs. 269534 ESTs 5. 6 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 5. 6 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 5. 6 451996 AW514021 Hs. 245510 ESTs 5. 6 422411 AW749443 Hs. 22511 ESTs 5. 6 438328 A1492261 Hs. 32450 ESTs 5. 6 433244 AB040943 Hs. 271285 KIAA1510 protein 5. 6 435191 R15912 Hs. 4817 Homo sapiens clone 24461 MRNA sequence 5. 5 418677 S83308 Hs. 87224 SRY (sex determining region Y)-box 5 5. 5 400859 5. 5 413625 AW451103 Hs. 71371 ESTs 5. 5 421863 A1952677 Hs. 108972 Homo sapiens mRNA : cDNA DKFZp434P228 (fr 5 5 434933 R91095 Hs. 4276 KIAA1701 protein 5. 5 438702 A1879064 Hs. 54618 ESTs 5. 5 452055 Api377431 Hs. 141693 hypothetical protein MGC10858 5. 5 430979 A1479755 Hs. 129010 ESTs 5. 5 412709 AL022327 Hs. 74518 KIAA0027 protein 5. 5 439920 H05430 Hs. 288433 neurotrimin 5. 5 424343 AW956360 Hs. 4748 adenylate cyclase activating polypepGde 5. 4 407846 AA426202 Hs. 40403 Cbp/p300-interacting transactivator, wit 5. 4 419235 AW470411 Hs. 288433 neurotrimin 5. 4 418030 BE207573 Hs. 83321 neuromedin B 5. 4 410330 AW023630 Hs. 46786 ESTs 5. 4 410781 Al375672 Hs. 165028 ESTs 5. 4 420658 AW965215 Hs. 336656 ESTs 5. 4 421308 AA687322 Hs. 192843 leucine zipper protein FKSG14 5. 4 443740 R56434 Hs. 21062 ESTs 5. 4 426457 AW894667 Hs. 169965 chimerin (chimaerin) 1 5. 4 450375 AA009647 Hs. 8850 a disintegrin and metaloproteinase doma 5. 4 412494 AL133900 Hs. 792 ADP-ribosylationfætordomainprotein1 5. 4

426600 NM_003378 Hs. 171014 VGF nerve growth factor inducible 5. 4 424432 AB037821 Hs. 146858 protocadhenn 10 5. 4 429250 H56585 Hs. 198308 tryptophan rich basic protein 5. 4 443785 AW449952 Hs. 190125 basic-helix-loop-helix-PAS protein 5. 4 436282 R91913 Hs. 272104 ESTs, Moderately similar to ALU1 HUMAN A 5. 4 404584 5. 3 430091 AB032958 Hs. 233023 KIAA1132 protein 5. 3 439845 AL355743 Hs. 56663 Homo sapiens EST from clone 41214, full 5. 3 424001 W67883 Hs. 137476 paternally expressed 10 5. 3 425073 W39609 Hs. 22003 solutecarierfamily6 (neurotransmitte 5. 3 426625 T78300 Hs. 300642 serologically defined colon cancer antig 5. 3 428137 AA421792 Hs. 170999 ESTs 5. 3 428679 AA431765 gb : zw80c03. s1SoarestestisNHT Homo sap 5. 3 438176 AW138970 Hs. 122113 ESTs 5. 3 440138 AB033023 Hs. 318127 hypotheGcalprotein FW10201 5. 3 451018 AW965599 Hs. 247324 mitochondrial ribosomal protein S14 5. 3 416340 N31772 Hs. 79226 fascicuMon and elongation protein zet 5. 3 435244 N77221 Hs. 187824 ESTs 5. 3 446035 Nom-006558 Hs. 13565 Sam68-like phosphotyrosine protein, T-ST 5. 3 424624 AB032947 Hs. 151301 Ca2a-dependentactivator proteinforsec 5. 3 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Orcadian Oscillat 5. 3 430437 A1768801 Hs. 169943 Homo sapiens cDNA FW 13569 fis, clone PL 5. 3 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 5. 2 453941 U39817 Hs. 36820 Bloom syndrome 5. 2 424998 U58515 Hs. 154138 chitinase 3-like 2 5. 2 423419 R55336 Hs. 23539 ESTs 5. 2 424922 BE386547 Hs. 217112 hypothetical protein MGC10825 5. 2 447359 NM 012093 Hs. 18268 adenylate kinase 5 5. 2 408206 AF041853 Hs. 43670 kinesin family member 3A 5. 2 421013 M62397 Hs. 1345 mutated in colorectal cancers 5. 2 429443 AB028967 Hs. 202687 potassium voltage-gated channel, Shal-re 5. 2 434367 AB020700 Hs. 3830 KIAA0893 protein 5. 2 444861 R46789 Hs. 76118 ubiquitn carboxyl-terminal esterase Lt 5. 2 446142 A1754693 Hs. 145968 ESTs 5. 2 448816 AB033052 Hs. 22151 KIAA1226 protein 5. 2 451050 AW937420 Hs. 69662 ESTs 5. 2 451106 BE382701 Hs. 25960 v-mycavianmyelocytomatosisviralelat 5. 2 439285 AL133916 Hs. 172572 hypothetical protein FU20093 5. 2 416737 AF154335 Hs. 79691 LIM domain protein 5. 2 424800 AL035588 Hs. 153203 MyoD family inhibitor 5. 2 443695 AW204099 Hs. 337720 ESTs, Weakly similar to AF1267801 retin 5. 2 415257 F03016 Hs. 27513 ESTs 5. 2 433929 Al375499 Hs. 27379 ESTs 5. 1 415651 A1207162 Hs. 3815 stathmin-like-protein RB3 5. 1 451027 AW519204 Hs. 40808 ESTs 5. 1 409172 Z99399 Hs. 118145 ESTs 5. 1 423343 AA324643 Hs. 246106 ESTs 5. 1 429172 AA447417 Hs. 285491 ESTs 5. 1 437268 Api754847 Hs. 227571 regulator of G-protein signalling 4 5. 1 451270 AW341392 Hs. 235795 ESTs 5. 1 452904 AL157581 Hs. 30957 Homo sapiens mRNA : cDNA DKFZp434E0626 (f 5. 1 420560 AW207748 Hs. 59115 ESTs 5. 1 418097 R45137 Hs. 21868 ESTs 5. 1 442910 Api365130 Hs. 11307 ESTs, Weakly similar to T19326 hypotheti 5. 1 434849 AW292765 Hs. 8053 ESTs 5. 1 413554 AA319146 Hs. 75426 secretogranin 11 (chromogranin C) 5. 1 414217 Api309298 Hs. 279898 Homo sapiens cDNA : FU23165 fis, clone L 5. 1 412068 S72043 Hs. 73133 metallothionein 3 (growth inhibitory fac 5. 0 413627 BE182082 Hs. 246973 ESTs 5. 0 418661 NM_001949 Hs. 1189 E2F transcription factor 3 5. 0 422438 AA445925 Hs. 270896 ESTs, Moderately similar to Z195 HUMAN Z 5. 0 423728 AW891294 Hs. 132136 solutecanierfamily4, sodiumbicãrbon 5. 0 431431 AL096711 Hs. 252953 HumanDNAsequencefromcloneRP3-403A15 5. 0 435087 AW975241 Hs. 23567 ESTs 5. 0 452097 AB002364 Hs. 27916 adisintegnn-likeandmetalloprotease (5. 0 410434 AF051152 Hs. 63668 toll-likereceplor2 4. 9 408692 AL040127 Hs. 34074 dipeptidylpepGdase VI 4. 9 407808 AA663559 Hs. 279789 histone deacetylase 3 4. 9 418940 H17739 Hs. 288513 HumanDNAsequencefromcloneRPS899C14 4, 9 425977 R15138 Hs. 165570 Homo sapiens clone 25052 mRNA sequence 4. 9 426814 AF036943 Hs. 172619 myelin transcription factor 1-like 4. 9 447112 H17800 Hs. 7154 ESTs 4. 9 449574 F05048 Hs. 175373 ESTs 4. 9 453652 AW009640 Hs. 28368 ESTs, Moderately similar to S65657 alpha 4. 9 423869 BE409301 Hs. 134012 C1q-related factor 4. 9 413248 T64858 Hs. 21433 hypotheGcal protein DKFZpS47J036 4. 9 449176 A1633545 Hs. 198072 ESTs 4. 9 448451 AW015994 gb : UI-H-BIOp-abh-g-09-0-Ui. s1 NCI_CGAP S 4. 8 402604 4. 8 436039 AW023323 Hs. 121070 ESTs 4. 8 448769 N66037 Hs. 38173 ESTs 4. 8 423678 AW963357 Hs. 7847 ESTs 4. 8 439451 AF086270 Hs. 278554 heterochromatin-like protein 1 4. 8

425870 R13406 Hs. 56782 ESTs 4. 8 408777 U71204 Hs. 47626 Ric (Drosophila)-like, expressed in neur 4. 8 413409 Api638418 Hs. 78580 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 4. 8 413623 AA825721 Hs. 246973 ESTs 4. 8 417246 Al760098 Hs. 21411 ESTs 4. 8 420900 AL045633 Hs. 44269 ESTs 4. 8 424153 AA451737 Hs. 141496 MAGE-like 2 4. 8 443539 A1076182 Hs. 134074 ESTs, Moderately similar to ALU6 HUMAN A 4. 8 448750 U95020 Hs. 21903 calcium channel, voltage-dependent beta 4. 8 454030 AW021429 Hs. 231980 ESTs 4. 8 424458 M29273 Hs. 1780 myelin associated glycoprotein 4. 8 444119 R41231 Hs. 184261 ESTs, Weakly similar to T26686 hypotheti 4. 8 407792 A1077715 Hs. 39384 putative secreted ligand homologous to f 4. 8 431462 AW583672 Hs. 256311 granin-like neuroendocrine peptide precu 4. 7 431103 M57399 Hs. 44 pteiotrophinfheparin binding growth fac 4. 7 429956 A1374651 Hs. 22542 ESTs 4. 7 435060 Al422719 Hs. 233349 ESTs. Weakly similar to fork head like p 4. 7 436203 BE384982 Hs. 5076 Homo sapiens cDNA : FLJ22128 fis, clone H 4. 7 448475 BE613134 Hs. 247474 hypothetical protein FLJ21032 4. 7 422222 Api699372 Hs. 193247 hypothetical protein DKFZp434A171 4. 7 431733 AW298410 Hs. 21475 ESTs 4. 7 449353 AA001220 Hs. 271369 ESTs 4. 7 452022 AW072330 Hs. 293875 ESTs 4. 7 454269 A1961060 Hs. 129908 KIAA0591 protein 4. 7 404541 4. 7 428t89 AA424030 Hs. 46627 ESTs 4. 7 409125 R17268 Hs. 259873 axonal transport of synapGc vesicles 4. 7 458435 Al418718 Hs. 144121 ESTs, Weakly similar to T46916 hypothefi 4. 6 425745 U44060 Hs. 14427 Homo sapiens cDNA : FLJ21800 fis, clone H 4. 6 413492 D87470 Hs. 75400 KIAA0280 protein 4. 6 419629 AB020695 Hs. 91662 KIAA0888 protein 4. 6 407638 AJ404672 Hs. 334483 hypothetical protein FW23571 4. 6 436140 W87355 Hs. 269587 ESTs 4. 6 439169 Api912122 Hs. 41095 ESTs 4. 6 443150 A1034467 Hs. 34650 ESTs 4, 6 451073 Api758905 Hs. 206063 ESTs 4, 6 451659 BE379761 Hs. 14248 ESTs 4. 6 452106 Al141031 Hs. 21342 ESTs 4. 6 451407 AA131376 Hs. 326401 fibroblast growth factor 12B 4. 6 448765 R15337 Hs. 21958 Homo sapiens mRNA ; cDNA DKFZp547D086 (fr 4. 6 430147 R60704 Hs. 234434 hairy/enhancer-of-split related with YRP 4. 6 437204 AL110216 Hs. 12285 ESTs, Weakly similar to 155214 salivary 4. 6 431117 AF003522 Hs. 250500 delta (Drosophila)-like 1 4. 5 422175 N79885 Hs. 6382 ESTs, HighlysimilartoT00391 hypolheti 4. 5 407889 R34556 Hs. 30800 ESTs. Weakly similar to S65657 alpha-1 C-4. 5 419343 AA456245 Hs. 85603 down-regulated by Ctnnbl, a 4. 5 421790 AW896201 Hs. 22654 sodium channel, voltage-gated, type 1, a 4. 5 429399 AA452244 Hs. 16727 ESTs 4. 5 450149 AW969781 Hs. 132863 Zic family member 2 (odd-paired Drosophi 4. 5 453118 AW195849 Hs. 252757 ESTs 4. 5 443455 AB001025 Hs. 9349 ryanodine receptor 3 4. 4 442613 A1004002 Hs. 130522 Kv channel-interacting protein ! 4. 4 429643 AA455889 Hs. 167279 FYVE-fingercontainingRab5effectorpro 4. 4 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h 4. 4 418845 AA852985 Hs. 89232 chromobox homolog 5 (Drosophila HP1 a'ph 4. 4 435202 A1971313 Hs. 170204 KIAA0551 protein 4. 4 437496 AA452378 Hs. 170144 Homo sapiens mRNA ; cDNADKFZp547J125 (fr 4. 4 451254 A1571016 Hs. 172967 ESTs 4. 4 439039 At656707 Hs. 48713 ESTs 4. 4 439979 AW600291 Hs. 6823 hypothetical protein FU10430 4. 4 441607 NM 005010 Hs. 7912 neuronal cell adhesion molecule 4. 4 424983 At742434 Hs. 169911 ESTs 4. 4 410611 AW954134 Hs. 20924 KIAA1628 protein 4. 4 402605 4. 4 409248 AB033035 Hs. 51965 KIAA1209 protein 4. 4 442222 A1061301 Hs. 164773 ESTs 4. 4 454027 R40192 Hs. 21527 Human DNA sequence from clone GS1-1 15M3 4. 4 454293 H49739 Hs. 134013 ESTs, ModeratelysimilartoHK61_HUMANH 4. 4 442832 AW206560 Hs. 253569 ESTs 4. 4 407304 AA565832 gb : nj32bO3. sl NCI_CGAP_M1 Homosapiens 4. 4 423279 AW959861 Hs. 290943 ESTs 4. 3 427194 AA399018 Hs. 250835 ESTs 4. 3 419723 AL120193 Hs. 92614 longevity assurance (LAG1. S. cerevisiae 4. 3 445810 AW265700 Hs. 155660 ESTs 4. 3 409734 BE161664 Hs. 56155 hypothetical protein 4. 3 410389 AW954049 Hs. 8177 ESTs. Weakly similar to PIHUB6 salivary 4. 3 411571 AA122393 Hs. 70811 hypotheGcalproteinFLJ20516 4. 3 433024 AA573847 Hs. 26549 KIAA1708 protein 4. 3 453202 AW085781 Hs. 26270 hypothetical protein FLJ11588 4. 3 425264 AA353953 Hs. 20369 ESTs, Weakly similar to gonadotropin ind 4. 3 416427 BE244050 Hs. 79307 Ræ/Cdc42 guanine exchange factor (GEF) 4. 3 431789 H19500 Hs. 269222 mitogen-activated protein kinase 4 4. 3 444600 R41398 Hs. 6996 ESTs 4. 3

454042 H22570 Hs. 172572 hypothetical protein FLJ20093 4. 3 441899 A1372588 Hs. 8022 TU3A protein 4. 3 425256 BE297611 Hs. 155392 collapsin response mediator protein 1 4. 3 410358 AW975168 Hs. 13337 ESTs, Weakly similar to unnamed protein 4. 2 430291 AV660345 Hs. 238126 CGI-49 protein 4. 2 433597 AA708205 Hs. 100343 ESTs 4. 2 444127 N63620 Hs. 13281 ESTs 4. 2 448507 AL133109 Hs. 21333 Homo sapiens mRNA cDNADKFZp566N1047 (f 4. 2 413589 AW452631 Hs. 313803 ESTs, HighlysimilartoAF1578331noncl 4. 2 408577 H50572 Hs. 19515 ESTs, Highly similar to NRG3_HUMAN PRO-N 4. 2 409719 A1769160 Hs. 108681 Homo sapiens brain tumor associated prot 4. 2 428536 At143139 Hs. 2288 visinin-like 1 4. 2 429118 H20669 Hs. 35406 ESTs, Highly similar to unnamed protein 4. 2 432865 Api753709 Hs. 152484 ESTs, Weakly similar to 138022 hypotheb 4. 2 447138 A1439112 Hs. 93828 ESTs, Weakly similar to 2109260A B cell 4. 2 450648 A1703366 Hs. 26766 ESTs 4. 2 451459 A1797515 Hs. 270560 ESTs, Moderately similar to ALU7 HUMAN A 4. 2 421686 AB011156 Hs. 106794 KIAA0584 protein 4. 2 452776 AA194540 Hs. 13522 ESTs, Wealdy similar to 138022 hypotheo 4. 2 436421 A1678031 Hs. 122813 ESTs, Weakly similar to ZN22 HUMAN ZINC 4. 2 423858 AL137326 Hs. 133483 Homo sapiens mRNA ; cDNA DKFZp434B0650 (f 4. 2 434001 AW950905 Hs. 3697 serine (orcysteine) proteinaeinhibito 4. 2 437380 AL359577 Hs. 112198 Homo sapiens mRNA : cDNA DKFZp547M073 (fr 4. 2 432328 Api572739 Hs. 195471 6-phosphofructo-2-kinaselfructose-2, 6-bi 4. 1 439607 BE540565 Hs. 159460 ESTs 4. 1 424028 AF055084 Hs. 153692 Homo sapiens cDNA FW 14354 fis, done Y7 4. 1 446936 H10207 Hs. 47314 ESTs 4. 1 424240 AB023185 Hs. 143535 calcium/camodulin-dependentproteinkin 4. 1 412446 A1768015 Hs. 92127 ESTs 4. 1 409953 AA332277 Hs. 57691 cadherin 18, type 2 4. 1 416220 N49776 Hs. 170994 hypothetical protein MGC10946 4. 1 419683 AA248897 Hs. 48784 ESTs 4. 1 426071 AW138057 Hs. 163835 ESTs 4. 1 428743 AL080060 Hs. 301549 Homo sapiens mRNA : cDNA DKFZp564H172 (fr 4. 1 432809 AA565509 Hs. 131703 ESTs 4. 1 440105 AA694010 Hs. 6932 Homosapiensclone23809mRNAsequence 4. 1 452039 Api922988 Hs. 172510 ESTs 4. 1 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring finge 4. 1 457561 AA331517 Hs. 286055 chimenn (chimaerin) 2 4. 1 429038 AL023513 Hs. 194766 seizure related gene 6 (mouse)-like 4. 1 433932 AW954599 Hs. 169330 neuronal protein 4. 1 436637 A1783629 Hs. 26766 ESTs 4. 1 439231 AW581935 Hs. 141480 Homo sapiens mRNA cDNADKFZp434N079 (fr 41 450530 NM_006668 Hs. 25121 cytochrome P450, subfamily 46 (cholester 4. 1 407721 Y12735 Hs. 38018 dua-speciEciqqrosine-(y)-phosphoryl 4. 1 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-sulfot 4. 1 410486 AW235094 Hs. 69233 zinc finger protein 4. 0 413916 N49813 Hs. 75615 apolipoprotein Gll 4. 0 438703 A1803373 Hs. 31599 ESTs 4. 0 424726 AK001007 Hs. 138760 Homo sapiens cDNA FW10145 hs, clone HE 4. 0 405771 4. 0 418841 NM_002332 Hs. 89137 low density lipoprotein-related protein 4. 0 421764 A1681535 Hs. 148135 sedneahreonine kinase 33 4. 0 424176 AL137273 Hs. 142307 hypothetical protein 4. 0 425773 N21279 Hs. 237749 ESTs 4. 0 427304 AA761526 Hs. 163853 ESTs 4. 0 428882 AA436915 Hs. 131748 ESTs, Moderately similar to ALU7 HUMAN A 4. 0 452834 A1638627 Hs. 105685 KlM1688protein 4. 0 453745 AA952989 Hs. 63908 hypothetical protein MGC14726 4. 0 405239 U89281 Hs. 11958 oxidaUve 3 alpha hydnoxystenoid dehydro 4. 0 413801 M62246 Hs. 35406 ESTs, Highly similar to unnamed protein 4. 0 429698 A1685086 Hs. 26339 ESTs, Weakly similar to S21348 probable 4. 0 435854 AJ278120 Hs. 4996 putative ankynn-repeat containing prote 40 439199 R40373 Hs. 26299 ESTs 4. 0 439450 R51613 Hs. 125304 ESTs 4. 0 446782 Al653048 Hs. 144006 ESTs 4. 0 419687 A1638859 Hs. 227699 ESTs, Weakly similar to T2D3_HUMAN TRANS 3. 9 402408 3. 9 453362 H14988 Hs. 107375 ESTs 3. 9 414219 W20010 Hs. 75823 ALL1-fusedgenehromchromosomelq 3. 9 420578 AA813546 Hs. 99034 GTP-binding protein Rho7 3. 9 425010 T16837 Hs. 4241 ESTs 3. 9 444230 H95537 Hs. 146067 ESTs 3. 9 441736 AW292779 Hs. 169799 ESTs 3. 9 418951 F07809 Hs. 89506 paired box gene 6 (aniridia, keratitis) 3. 9 406311 3. 9 408460 AA054726 Hs. 285574 ESTs 3. 9 410658 AW105231 Hs. 192035 ESTs 3. 9 414699 A1815523 Hs. 76930 synuclein, alpha (non A4 component of am 3. 9 418849 AW474547 Hs. 53565 HomosapiensPIG-MmRNAformannosyltran 3. 9 429477 A1275514 Hs. 6658 ESTs 3. 9 433766 AA609234 Hs. 112669 ESTs 3. 9 436190 AK001059 gb : Homo sapiens cDNA FLJ10197 fis, clone 3. 9

447891 R41754 Hs. 6496 ESTs 3. 9 450221 AA328102 Hs. 24641 cytoskeleton associated protein 2 3. 9 404283 3. 9 453919 AW959912 Hs. 7076 KIAAL 705 protein 3. 9 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 3. 9 412754 AW160375 Hs. 74565 amyloid beta (A4) precursor-like protein 3. 9 445314 Api689948 Hs. 65489 Homo sapiens cDNA : FU21517 6s, clone C 3. 9 435652 N32388 Hs. 334370 uncharactenzedhypothatamus protein HBE 3. 9 407378 AA299264 Hs. 57776 ESTs, Moderately similar to 138022 hypot 3. 9 438054 AA776626 Hs. 62183 ESTs 3. 9 436420 AA443966 Hs. 31595 ESTs 3. 9 445133 AW157646 Hs. 153506 ESTs 3. 9 432590 A1609273 Hs. 110783 ESTs 3. 9 453331 A1240665 Hs. 8895 ESTs 3. 9 410227 AB009284 Hs. 61152 exostoses (multiple)-like2 3. 8 424635 AA420687 Hs. 115455 HomosapienscDNAFW14259fis, clonePL 3. 8 451489 NM 005503 Hs. 26468 amyloid beta (A4) precursor protein-bind 3. 8 447247 AW369351 Hs. 287955 Homo sapiens cDNA FU13090 fis, clone NT 3. 8 448302 Api480208 Hs. 182906 Homo sapiens mRNA for KIAA1872 protein, 3. 8 415669 NM 005025 Hs. 78589 serine (or cysteine) proteinase inhibito 3. 8 417355 D13168 Hs. 82002 endothelin receptor type 8 3. 8 446727 AB011095 Hs. 16032 KIAA0523 protein 3. 8 424340 AA339036 Hs. 7033 ESTs 3. 8 423346 A1267677 Hs. 127416 synaptojanin 1 3. 8 412788 AA120960 Hs. 198416 ESTs 3. 8 404593 3. 8 416856 N27833 Hs. 269028 ESTs, Weakly similar to 138022 hypotheb 3. 8 429896 AA460367 Hs. 224223 ESTs, Moderately similar to 138022 hypot 3. 8 439619 AW975998 Hs. 58595 ESTs, Weakly similar to 138022 hypotheG 3. 8 439634 W79377 Hs. 167 microtubule-associated protein 2 3. 8 440322 AA879430 gb : oj91dO8. s1SoaresNFLTGBCS1 Homos 3. 8 447761 AF061573 Hs. 19492 pnotocædherin 8 3. 8 452453 A1902519 gb : QV-BT009-10119&051 BT009 Homo sapien 3. 8 439671 AW162840 Hs. 6641 kinesin family member 5C 3. 8 447937 AL109716 Hs. 20034 HomosapiensmRNAfuliEngthinseXcDN 3. 8 459278 AW294659 Hs. 34054 Homo sapiens cDNA : FU22488 fis, clone H 3. 8 447028 A1973128 Hs. 167257 brain link protein-1 3. 8 449458 A1805078 Hs. 208261 ESTs 3. 8 445888 AF070564 Hs. 13415 Homo sapiens clone 24571 mRNA sequence 3. 8 407385 AA610150 Hs. 272072 ESTs, Weakly similar to 138022 hypotheti 3. 8 428841 A1418430 Hs. 104935 ESTs 3. 8 430643 AW970065 Hs. 287425 MEGF10 protein 3. 8 422263 AA307639 Hs. 129908 KIAA0591 protein 3. 8 451625 R56793 Hs. 106576 alanine-glyoxylate aminotransferase 2-li 3. 8 439236 BE160952 Hs. 247117 ESTs, ModeratelysimilartoALUF_HUMAN ! 3. 8 441928 A1370188 Hs. 211454 ESTs 3. 8 441797 Api936933 Hs. 214635 ESTs 3. 7 414922 D00723 Hs. 77631 glycine cleavage system protein H (amino 3. 7 425588 F07396 Hs. 46751 ESTs 3. 7 437007 AA741300 Hs. 202599 ESTs, Weakly similar to l38022 hypotheG 3. 7 435793 AB037734 Hs. 4993 KIAA1313 protein 3. 7 443682 AI383061 Hs. 47248 ESTs, HighlysimilartosimilartoCdc14 3. 7 425741 AF052152 Hs. 159412 Homo sapiens clone 24628 mRNA sequence 3. 7 418211 BE244746 Hs. 247474 hypothetical protein FLJ21032 3. 7 440080 AW051597 Hs. 143707 ESTs 3. 7 452898 AA814497 Hs. 78792 ESTs 3. 7 435575 AF213457 Hs. 44234 triggering receptor expressed on myeloid 3. 7 409234 A1879419 Hs. 27206 ESTs 3. 7 420489 AA815089 Hs. 193513 ESTs 3. 7 426890 AA393167 Hs. 41294 ESTs 3. 7 438849 W28948 Hs. 10762 ESTs 3. 7 441869 NM003947 Hs. 8004 huntingtin-associated protein interactin 3. 7 448796 AA147829 Hs. 301431 endothelial zinc finger protein induced 3. 7 459318 NM000038 gb : Homo sapiens adenomatosis polyposis c 3. 7 459518 Al937419 Hs. 294069 Homo sapiens cDNA FLJ 13384 fis, clone PL 3. 7 434444 A1765276 Hs. 101257 hypothetical protein MGC3295 3. 7 421183 AL135740 Hs. 102447 TSC-22-like 3. 7 410555 U92649 Hs. 64311 adisintegnnandmetalloproteinasedoma 3. 7 421637 AF035290 Hs. 106300 Homo sapiens clone 23556 mRNA sequence 3. 7 418522 AA605038 Hs. 7149 Homo sapiens cDNA : FU21950 fis, clone H 3. 7 420807 AA280627 Hs. 57846 ESTs 3. 7 449961 AW265634 Hs. 133100 ESTs 3 7 422634 NM016010 Hs. 116821 CGI-62protein 37 421030 AW161357 Hs. 101174 microtubule-associated protein tau 3. 7 427099 AB032953 Hs. 173560 odd OzAen-m homolog 2 (Drosophila, mous 3. 7 452355 N54926 Hs. 29202 G protein-coupled receptor 34 3. 7 440483 A1200836 Hs. 150386 ESTs 3 7 429597 NM003816 Hs. 2442 a disintegnn and metalloproteina5e doma 3. 7 423756 AA828125 gb : od71a09. sl NCI_CGAP_Ov2Homosapiens 3. 6 425187 AW014486 Hs. 22509 ESTs 3. 6 434859 BE255080 Hs. 299315 collapsin response mediator protein-5 ; C 3. 6 413199 M62843 Hs. 75236 ELAV (embryonic lethal, abnormal vision, 3. 6 445729 H21066 Hs. 13223 Homo sapiens mRNA full length insert cDN 3. 6

416120 H46739 gb : yo14hO2. si Soares adult brain N2b5HB5 3. 6 429239 AA448419 Hs. 45209 ESTs 3. 6 419086 NM_000216 Hs. 89591 Kallmann sffldrome 1 sequen 3. 6 446659 A1335361 Hs. 226376 ESTs 3. 6 426757 AW205640 Hs. 158206 ESTs 3. 6 418819 AA228776 Hs. 191721 ESTs 3. 6 458332 A1000341 Hs. 220491 ESTs 3. 6 408826 AF216077 Hs. 48376 Homo sapiens clone HB-2 mRNA sequence 3. 6 410343 AA084273 Hs. 76561 ESTs, Weakly similar to S47072 finger pr 3. 6 410507 AA355288 Hs. 40834 transitional epithelia response protein 3. 6 422977 AA631498 gb : np83h04. sl NU_CGAP_Thyl Homosapiens 3. 6 425305 AA363025 Hs. 155572 Human clone 23801 MRNA sequence 3. 6 428002 AA418703 gb : zv98c03. s1 Soares NhHMPu S1 Homosapi 3. 6 428505 AL035461 Hs. 2281 chromogranin B (secretogranin 1) 3. 6 430530 AA480870 Hs. 47660 ESTs 3. 6 436425 Al913146 Hs. 318725 CGI-72 protein 3. 6 438078 A1016377 Hs. 131693 ESTs 3. 6 442927 A1024347 Hs. 131519 ESTs 3. 6 446242 N66336 Hs. 7360 ESTs 3. 6 448831 AL080123 Hs. 22182 zinc finger protein 23 (KOX 16) 3. 6 450474 AW872844 Hs. 201919 ESTs 3. 6 452198 A1097560 Hs. 61210 ESTS, Weakly similar to 138022 hypotheti 3. 6 455800 R22479 Hs. 167073 Homo sapiens cDNA FU13047 fis, clone NT 3. 6 436443 AW138211 Hs. 128746 ESTs 3. 6 426514 BE616633 Hs. 170195 bonemorphogenetcprotein7 (osteogenic 3. 6 456038 Axa203285 Hs. 294141 ESTs, Weakiysimitartoaltemativelysp 3. 6 408902 AW014869 Hs. 5510 ESTs 3. 6 442950 A1500417 Hs. 46764 ESTs 3. 6 423905 AW579960 Hs. 135150 lung type-I cell membrane-associated gly 3. 6 425478 AB007953 Hs. 268840 ESTs 3. 6 453884 AA355925 Hs. 36232 KIAA0186 gene product 3. 6 404721 3. 6 408453 A1369838 Hs. 45127 chondroitin sulfate proteoglycan 5 (neur 3. 6 440553 AA889416 Hs. 295362 Homo sapiens CDNA FU14459 fis, clone HE 3. 5 446372 A8020644 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 3. 5 413999 N46124 Hs. 34460 ESTs 3. 5 421458 NM 003654 Hs. 104576 carbohydrate (keratan sulfate Gal-6) sul 3. 5 425017 AL119305 Hs. 288405 ESTs 3. 5 435958 H98180 Hs. 117975 ESTs 3. 5 415101 R45531 Hs. 144534 ESTs 3. 5 451320 AW118072 Hs. 89981 diacylglycerol kinase, zeta (104kD) 3. 5 430290 A1734110 Hs. 136355 ESTs 3. 5 416836 D54745 Hs. 80247 cholecystokinin 3. 5 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 3. 5 419412 AW161058 Hs. 90297 synuclein, beta 3. 5 437860 AA333063 Hs. 279898 Homo sapiens cDNA FLJ23165 fis, clone L 3. 5 452689 F33868 Hs. 284176 transferrin 3. 5 416661 AA634543 Hs. 79440 IGF-il mRNA-binding protein 3 3. 5 427491 R43279 Hs. 22574 ESTs, Weakly similar to 138022 hypotheti 3. 5 428037 N47474 Hs. 89230 potassium intermediate/small conductance 3. 5 444584 A1168422 gb : ok30ell. xi SoaresNSFF89WOTPAPS 3. 5 408296 AL117452 Hs. 44155 DKFZP586G1517 protein 3. 5 453775 NM 002916 Hs. 35120 replication factor C (activator 1) 4 (37 3. 5 412659 AW753865 Hs. 74376 olfactomedin related ER localized protei 3. 5 429077 AB028983 Hs. 2352 adenylate cyclase 2 (brain) 3. 5 436887 AW953157 Hs. 193235 hypothetical protein DKFZp547D155 3. 5 450784 AW246803 Hs. 47289 ESTs 3. 5 446827 AW451243 Hs. 157069 ESTs 3. 5 436434 N50465 Hs. 92927 putative 47 kDa protein 3. 5 412777 A1335773 Hs. 270123 ESTs 3. 5 436476 AA326108 Hs. 33829 bHLH protein DEC2 3. 5 408601 U47928 Hs. 86122 protein A 3. 4 429401 AW296102 Hs. 99272 ESTs, Weakly similar to S32567 A4 protei 3. 4 448425 A1500359 Hs. 233401 ESTs 3. 4 418727 AA227609 Hs. 94834 ESTs 3. 4 451729 AW160725 Hs. 312469 ESTs 3. 4 435910 A1084152 Hs. 21782 ESTs. Weakly similar to ALU7 HUMAN ALU S 3. 4 434577 R37316 Hs. 179769 Homo sapiens cDNA : FU22487 fis, clone H 3. 4 414598 A1094221 Hs. 135150 lung type-I cell membrane-associated gly 3. 4 439627 BE621702 Hs. 29076 hypothetical protein FU21841 3. 4 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 3. 4 423992 AW898292 Hs. 137206 Homo sapiens mRNA ; cDNA DKFZp564H1663 (f 3. 4 426249 F05422 Hs. 168352 nucleoponn-like protein 1 3. 4 426968 U07616 Hs. 173034 amphiphysin (Stiff-Mann syndrome with br 3. 4 430388 AA356923 Hs. 240770 nuclear cap binding protein subunit 2, 2 3. 4 435061 A1651474 Hs. 163944 ESTs 3. 4 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7, S. cerevisi 3. 4 449714 AB033015 Hs. 23941 KIAA1189 protein 3. 4 443392 A1055821 Hs. 293420 ESTs 3. 4 410082 AA081594 Hs. 158311 Musashi (Drosophila) homolog 1 3. 4 445337 NM 013280 Hs. 12523 fibronectin leucine rich transmembrane p 3. 4 408493 BE206854 Hs. 46039 phosphoglycerate mutase 2 (muscle) 3. 4 432731 R31178 Hs. 287820 fibronectint 3. 4

448758 AB018311 Hs. 21917 KIAA0768 protein 3. 4 432613 AW081698 Hs. 80712 K) AA0202 protein 3. 4 434164 AW207019 Hs. 148135 serine/threoninekinae33 34 425294 AF033827 Hs. 155553 HNK-1 sulfotransferase 3. 4 410108 AA081659 Hs. 318775 OSBP-related protein 6 3. 4 406815 AA833930 Hs. 288036 tRNA isopentenylpyrophosphate transfera 3. 4 402855 3. 3 422170 A1791949 Hs. 112432 anG-Mullerian hormone 3. 3 445034 AW293376 Hs. 143659 ESTs 3. 3 424378 W28020 Hs. 167988 neural cell adhesion molecule 1 3. 3 423611 AB011163 Hs. 129908 KIAA0591 protein 3. 3 435593 R88872 Hs. 4964 DKFZP586J1624 protein 3. 3 404819 3. 3 436607 AW661783 Hs. 211061 ESTs 3. 3 427315 AA179949 Hs. 175563 HomosapiensmRNA ; cDNA DKFZp564N0763 (f 3. 3 452693 T79153 Hs. 48589 zinc finger protein 228 3. 3 454996 AW850180 gb : lL3-CT0219^271099-022-CO9 CT0219 Homo 3. 3 406927 M26460 gb : Homo sapiens (clone 104) reGinoblasto 3. 3 409045 AA635062 Hs. 50094 Homo sapiens mRNA ; cDNA DKFZp43400515 (f 3. 3 415238 R37780 Hs. 21422 ESTs 3. 3 417845 AL117461 Hs. 82719 HomosapiensmRNA ; cDNADKFZp586F1822 (f 3. 3 421192 AA833718 Hs. 204529 KIAA1806 protein 3. 3 426695 AW118191 Hs. 112729 ESTs 3. 3 438885 A1886558 Hs. 184987 ESTs 3. 3 451762 AF222980 Hs. 26985 disrupted in schizophrenia 1 3. 3 452103 R42764 Hs. 339654 ESTs, Weakly similar to 138022 hypothefi 3. 3 453590 AF150278 Hs. 33578 KIAA0820 protein 3. 3 453616 NM 003462 Hs. 33846 dynein, axonemal, light intermediate pol 3. 3 457285 A1038858 Hs. 130522 Kv channel-interacting protein 1 3. 3 436045 A8037723 Hs. 5028 DKFZP56400423 protein 3. 3 437470 AL390147 Hs. 134742 hypotheGcalprotein DKFZp547D065 3. 3 448520 AB002367 Hs. 21355 doublecorGn and CaM kinase-like t 3. 3 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel 3. 3 432656 NM000246 Hs. 3076 MHC class II transactivator 3. 3 443898 AW804296 Hs. 9950 Sec61 gamma 3. 3 423582 BE000831 Hs. 23837 Homo sapiens cDNA FLJ 11812 fis, clone HE 3. 3 445953 A1612775 Hs. 145710 ESTs 3. 3 427940 AA417812 Hs. 38775 ESTs 3. 3 414683 S78296 Hs. 76888 hypothetical protein MGC12702 3. 3 428484 AF104032 Hs. 184601 solute cartier family 7 (cationic amino 3. 3 420649 A1866964 Hs. 124704 ESTs, Moderately similar to S65657 alpha 3. 3 419498 AL036591 Hs. 20887 hypothetical protein FLJ10392 3. 3 457579 AB030816 Hs. 36761 HRAS-like suppressor 3. 3 436556 A) 364997 Ws. 7572 ESTs 3. 2 424369 R87622 Hs. 26714 KIAA1831 protein 3. 2 457065 A1476318 Hs. 192480 ESTs 3. 2 440210 AW674562 Hs. 125296 ESTs 3. 2 444513 AL120214 Hs. 7117 glutamate receptor, ionotropic, AMPA 1 3. 2 434353 AA630863 Hs. 131375 ESTs, Moderately similar to ALUB HUMAN ! 3. 2 414430 A1346201 Hs. 76118 ubiquiGncarboxyl-terminalesteraseL1 3. 2 439924 A1985897 Hs. 125293 ESTs 3. 2 411505 AF155659 Hs. 70565 molybdenum cofactor synthesis 2 3. 2 423175 W27595 Hs. 18653 hypothetical protein FU 14627 3. 2 415115 AA214228 Hs. 127751 hypothetical protein 3. 2 407878 D87468 Hs. 40888 activity-regulated cytoskeleton-associat 3. 2 410274 AA381807 Hs. 61762 hypoxia-inducible protein 2 3. 2 437762 T78028 Hs. 154679 synaptotagmin 1 3. 2 438944 AA302517 Hs. 92732 KIAA1444 protein 3. 2 450313 A1038989 Hs. 332633 Bardet-Biedi syndrome 2 3. 2 409459 D86407 Hs. 54481 low density lipoprotein receptor-related 3. 2 410953 AW811766 Hs. 334858 hypothetical protein MGC12250 3. 2 418527 AA450386 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 3. 2 420081 AW510776 Hs. 94958 tubulin tyrosine ligase-like 1 3. 2 429496 AA453800 Hs. 192793 ESTs 3. 2 430099 AW194988 Hs. 20537 hypothetical protein FLJ13942 3. 2 434928 AW015595 Hs. 4267 Homosapiensclones24714and24715mRNA 3. 2 435532 AW291488 Hs. 117305 Homo sapiens, clone IMAGE : 3682908, mRNA 3. 2 438306 AW188266 Hs. 163645 ESTs 3. 2 439274 AF086092 Hs. 48372 ESTs 3. 2 440847 AA907511 Hs. 130178 ESTs 3. 2 447750 A1422234 Hs. 143434 contain 1 3. 2 455350 AW901809 gb : QVO-NN1020-170400-195-h02NN1020Homo 3. 2 430890 X54232 Hs. 2699 glypican 1 3. 2 420568 F09247 Hs. 247735 protocadherin åpha 10 3. 2 410768 AF038185 Hs. 66187 Homosapiensclone23700mRNAsequence 3. 2 427450 A8014526 Hs. 178121 KIAA0626 gene product 3. 2 430456 AA314998 Hs. 241503 hypothetical protein 3. 2 430181 AF065314 Hs. 234785 cyclic nucleotide gated channel alpha 3 3. 2 418512 AW498974 Hs. 89981 diacylglycerol kinase, zeta (104kD) 3. 2 419912 AF249745 Hs. 6066 Rho guanine nucleotide exchangefactor 3. 2 450689 A1369275 Hs. 243010 Homo sapiens cDNA FW 14445 hs, clone HE 3. 2 424899 AL119387 Hs. 119062 ESTs 3. 2 436277 R88520 Hs. 120917 ESTs 3. 2

451455 Api937227 Hs. 8821 hepcidin antimicrobial pepGde 3. 2 445078 A1869975 Hs. 4775 junctophilin 3'3. 2 447746 AW015920 Hs. 161359 ESTs 3. 2 435458 F11872 Hs. 4892 Homosapiensclone24841mRNAsequence 3. 2 427729 AB033100 Hs. 300646 MAA protein (similar to mouse paladin) 3. 2 417417 F05745 Hs. 89512 ATPase, Ca-transporting, plasma membra 3. 1 438810 AW897846 Hs. 6421 hypothetical protein DKFZp761N09121 3. 1 439570 T79925 Hs. 269165 ESTs, Weakly similar to AW 1 _HUMAN ALU S 3. 1 432527 AW975028 Hs. 102754 ESTs 3. 1 416801 X98834 Hs. 79971 sal (Drosophila)-like 2 3. 1 421988 AW450481 Hs. 161333 ESTs 3. 1 426509 M31166 Hs. 2050 pentaxin-related gene, rapidly induced b 3. 1 408786 AA773187 Hs. 294027 ESTs 3. 1 433494 AB029396 Hs. 3353 beta-1, 3glucuronyltransérase1 (91ucur 3. 1 412723 AA648459 Hs. 335951 hypotheucal protein AF301222 3. 1 418329 AW247430 Hs. 84152 cystathionine-beta-synthase 3. 1 439456 A1752409 Hs. 109314 hypothetical protein FU20980 3. 1 428832 AA578229 Hs. 324239 ESTs, ModeratelysimilartoZN91_HUMANZ 3. 1 452780 BE171598 Hs. 13522 ESTs, Weakly similar to 138022 hypotheti 3. 1 438192 Api859065 Hs. 337620 HomosapiensAFG3L1isofomm1mRNA, part 3. 1 424939 AK000059 Hs. 153881 Homo sapiens NY-REN-62 antigen mRNA, par 3. 1 403053 R58624 Hs. 2186 eukaryotic translation elongation factor 3. 1 404299 3. 1 407864 AF069291 Hs. 40539 chromosome 8 open reading frame 1 3. 1 410181 AI468210 Hs. 261285 pleiotropicegulator1 (PRL1, Arabidops 3. 1 418852 BE537037 Hs. 273294 hypotheticalprotein FLJ20069 3. 1 449101 AA205847 Hs. 23016 G protein-coupled receptor 3. 1 453240 A1969564 Hs. 166254 hypothe6cal protein DKFZp5661133 3. 1 440486 BE243513 Hs. 7212 hypothetical protein PP1044 3. 1 408096 BE250162 Hs. 83765 dihydrofolate reductase 3. 1 439864 A1720078 Hs. 291997 ESTs, Weakly similar to A47582 B-cell gr 3. 1 414706 AW340125 Hs. 76989 KIAA0097 gene product 3. 1 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 3. 1 426855 AL117427 Hs. 172778 Homo sapiens mRNA ; cDNADKFZp566P013 (fr 3. 1 425683 AB037813 Hs. 159200 hypothetical protein OKFZp762K222 3. 1 410126 BE169274 Hs. 169387 KIAA0036 gene product 3. 1 435312 AJ243396 Hs. 4865 voltage-gated sodium channel beta-3 subu 3. 1 425491 AA883316 Hs. 255221 ESTs 3. 1 456273 AF154846 Hs. 1148 zinc finger protein 3. 1 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 3. 1 445255 NM 014841 Hs. 12477 synaptosomal-asociatedprotein, 91 kDa 3. 1 432154 A1701523 Hs. 112577 ESTs 3. 1 453128 AW026516 Hs. 31791 acylphosphatase 2, muscle type 3. 1 438458 AW975186 gb : EST387294 MAGE resequences, MAGN Homo 3. 1 448616 AF035621 Hs. 21611 kinesin family member 3C 3, 0 429281 AA830856 Hs. 29808 HomosapienscDNA : FLJ21122 fis, clone C 3. 0 443906 AA348031 Hs. 7913 ESTs 3. 0 417318 AW953937 Hs. 12891 ESTs 3. 0 452619 AW298597 Hs. 61884 Homo sapiens, clone IMAGE : 4298026, mRNA, 3. 0 444153 AK001610 Hs. 10414 hypothetical protein FLJ10748 3. 0 408790 AW580227 Hs. 47860 neurotrophic tyrosine kinase, receptor, 3. 0 426327 W03242 Hs. 44898 Homo sapiens clone TCCCTA00151 mRNA sequ 3. 0 451468 AW503398 Hs. 293663 ESTs, Moderately similar to 138022 hypot 3. 0 422758 AF152329 Hs. 284180 protocadhenngammasubfamilyC, 3 3. 0 421633 AF121860 Hs. 106260 sorting nexin 10 3. 0 428361 NM 015905 Hs. 183858 transcriptional intermediary factor 1 3. 0 418932 L34059 Hs. 89484 cadhenn 4, tpe 1, Rcadherin (refinal) 3. 0 416805 F13271 Hs. 79981 Humanclone23560mRNAsequence 3. 0 419518 U79289 Hs. 90798 Human clone 23695 mRNA sequence 3. 0 422709 AA315331 Hs. 153485 ESTs 3. 0 423135 N67655 Hs. 26411 ESTs 3. 0 424901 Z11933 Hs. 182505 POU domain, class 3, transcription facto 3. 0 426617 W58006 Hs. 266258 endonuclease Glike 1 3. 0 427386 AW836261 Hs. 337717 ESTs 3. 0 429859 NM 007050 Hs. 225952 protein tyrosine phosphatase, receptor t 3. 0 435071 D60683 Hs. 35495 ESTs 3. 0 435092 AL137310 Hs. 4749 HomosapiensmRNA ; cDNADKFZp761E13121 (3. 0 436211 AK001581 Hs. 334828 hypothetical protein FU10719 : KIAA1794 3. 0 436936 AL134451 Hs. 197478 ESTs 3. 0 445855 BE247129 Hs. 145569 ESTs 3. 0 452294 Api871925 Hs. 117895 ESTs, ModeratelysimilarloA47582B-cel 30 433980 AA137152 Hs. 286049 phosphoserineaminotransferase 30 430228 AW950939 Hs. 6382 ESTs, Highly similar to T00391 hypotheti 3. 0 451026 AA013218 Hs. 157492 cer-d4 (mouse) homolog 3. 0 435232 NM 001262 Hs. 4854 cyclin-dependentkinaeinhibitor2C (p1 30 439566 AF086387 gb : Homo sapiens full length insert cDNA 3. 0 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 3. 0 416586 D44643 Hs. 14144 secreted modular calcium-binding protein 3. 0 416874 H98752 Hs. 42568 ESTs 3. 0 410386 W26187 Hs. 3327 Homo sapiens cDNA : FU22219 fis, clone H 3. 0 411411 AA345241 Hs. 55950 ESTs, Weakly similar to K1AA1330 protein 3. 0 424066 Z99348 Hs. 112461 ESTs, Weakly similar to 138022 hypotheti 3. 0 404048 3. 0

429163 AA884766 gb : am20a10. s1 Soares NFL T GBC S1 Homos 3. 0 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 3. 0 418196 A1745649 Hs. 26549 KIAA1708 protein 3. 0 434131 A1858275 Hs. 143659 ESTs 3. 0 441255 R06350 Hs. 171635 ESTs 2. 9 453900 AW003582 Hs. 226414 ESTs, Weakly similar to ALU8_HUMAN ALU S 2. 9 453905 Nom002314 Hs. 36566 UM domain kinase 1 2. 9 416602 NM_006159 Hs. 79389 net (chicken)-like 2 2. 9 431173 AW971198 Hs. 294068 ESTs'2. 9 425599 AW366745 Hs. 214140 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 9 436401 A1087958 Hs. 29088 ESTs 2. 9 422960 AW890487 Hs. 63984 cadhenn 13, H-cadherin (heart) 2. 9 451558 NM 001089 Hs. 26630 ATP-binding cassette, sub-family A (ABC1 2. 9 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 2. 9 433149 BE257672 Hs. 42949 hypothetical protein HES6 2. 9 434811 AW971205 Hs. 114280 ESTs 2. 9 425897 AA935315 Hs. 48965 Homo sapiens cDNA FW21693 fis, clone C 2. 9 452092 BE245374 Hs. 27842 hypotheGcalprotein FW11210 2. 9 453496 AA442103 Hs. 33084 solute carrier family 2 (facilitated glu 2. 9 411124 AW196937 Hs. 53929 ESTs. WeaklysimilartoALUB_HUMAN ! ! ! ! 2. 9 419227 BE537383 Hs. 89739 cholinergic receptor, nicotinic, beta po 2. 9 427651 AW405731 Hs. 18498 Homo sapiens cDNA FW 12277 fis, done MA 2. 9 441707 R42637 Hs. 21963 hypothetical protein DKFZp761B0514 2. 9 435741 Api240668 Hs. 113099 ESTs 2. 9 437273 AL137451 Hs. 120873 ESTs, Highly similar to T46266 hypotheG 2. 9 422939 AW394055 Hs. 98427 ESTs, Weakly similar to 138022 hypotheU 2. 9 439376 AA883521 Hs. 222064 ESTs 2. 9 439935 S75105 Hs. 301676 glutamate receptor, ionotropic, kainate 2. 9 437267 AW511443 Hs. 258110 ESTs 2. 9 453740 AL120295 Hs. 311809 ESTs, Moderately similar to PC4259 ferri 2. 9 400250 2. 9 400992 2. 9 408814 N62499 Hs. 176227 hypothetical protein FU 11155 2. 9 411849 AW964970 Hs. 18861 ESTs, Moderately similar to KIAA1276 pro 2. 9 414853 U31116 Hs. 77501 sarcoglycan, beta (43kD dystrophin-assoc 2. 9 423751 AW235633 Hs. 46525 ESTs 2. 9 426910 AA470023 Hs. 190089 ESTs. ModeratehysimilartoALU1_HUMANA 2. 9 450203 AF097994 Hs. 301528 L-kynurenine/alpha-aminoadipate aminotra 2. 9 459311 R40192 Hs. 21527 Human DNA sequence from clone GS1-115M3 2. 9 425304 AA463844 Hs. 31339 fibroblast growth factor 11 2. 9 428500 A1815395 Hs. 184641 fatty acid desaturase 2 2. 9 421641 A1638184 Hs. 106334 Homo sapiens clone 23836 mRNA sequence 2. 9 421141 AW117261 Hs. 125914 ESTs 2. 9 407870 AB032990 Hs. 40719 hypothetical protein KIAA1164 2. 9 456723 Z43902 Hs. 4748 adenylate cyclase activating polypeptide 2. 9 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 2. 9 421483 Nom-003388 Hs. 104717 hypothetical protein MGC11333 2. 9 412190 R16180 Hs. 274461 ESTs 2. 9 446131 NM 000929 Hs. 290 phospholipase A2, group V 2. 9 441668 A1611973 Hs. 127525 ESTs 2. 9 437387 A1198874 Hs. 28847 AD026 protein 2. 9 423420 Api571364 Hs. 128382 HomosapiensmRNA ; cDNADKFZp76111224 (f 2. 9 427958 AA418000 Hs. 98280 potassium intermediate/small conductance 2. 9 429084 AJ001443 Hs. 195614 splicing factor 3b, subunit 3, 130kD 2. 9 447067 R42098 Hs. 21964 ESTs 2. 9 430887 N66801 Hs. 260287 KIAA1841 protein 2. 9 441824 AB007871 Hs. 7977 KIAA0411 gene product 2. 9 424126 AA335635 Hs. 96917 ESTs 2. 9 408739 W01556 Hs. 238797 ESTs, Moderately similar to 138022 hypot 2. 9 447422 BE618703 Hs. 98258 orthopedia (Drosphila) homolog 2. 9 435615 Y15065 Hs. 4975 potassium voltage-gated channel, KOT-lik 2. 9 446997 AA383439 Hs. 16758 Spir-1 protein 29 433573 AF234887 Hs. 57652 cadherin, EGF LAG seven-pass G-type rece 2. 9 408447 AK002089 Hs. 45080 Homo sapiens CDNA FUl 1227 fis, clone PL 2. 9 419586 A1088485 Hs. 144759 ESTs. Weakly similar to 138022 hypotheti 2. 8 417022 NM_014737 Hs. 80905 Ras association (RaIGDS/AF-6) domain fam 2. 8 408432 AW195262 gb : xn67bO5. xl NCI_CGAP_CML1 Homo sapiens 2. 8 420320 AB002361 Hs. 96633 KIAA0363 protein 2. 8 425241 AA324624 Hs. 155247 aldolase C, fructose-bisphosphate 2. 8 428670 AA431682 Hs. 134832 ESTs 2. 8 424415 NM. 001975 Hs. 146580 enolase 2, (gamma, neuronal) 2. 8 409185 AW961601 Hs. 252406 hypothetical protein FU12296 similar to 2. 8 411555 AF113537 Hs. 70669 HMP19protein 2. 8 426847 S78723 Hs. 298623 Shydroxytryptamine (serotonin) receptor 2. 8 458809 AW972512 Hs. 20985 sin3-asociated polypepUde, 30kD 2. 8 420071 AB028985 Hs. 94806 ATP-binding cassette, sub-family A (ABC1 2. 8 424572 M19650 Hs. 150741 2', 3'-cyclic nucleoUde 3'phosphodieste 2. 8 444670 H58373 Hs. 332938 hypothetical protein MGC5370 2. 8 411089 AA456454 Hs. 183418 cell division cycle 2-like 1 (PITSLRE pr 2. 8 416111 AA033813 Hs. 79018 chromatin assembly factor 1, subunit A 2. 8 440637 AW900115 Hs. 7309 Homosapiensclone23741 mRNAsequence 2. 8 408554 AA836381 Hs. 315111 nuclear receptor co-repressor/HDAC3 comp 2. 8 403056 R58624 Hs. 2186 eukaryotic translation elongation factor 2. 8

423449 A1497900 Hs. 33067 ESTs 2. 8 424188 AW954552 Hs. 142634 zinc finger protein 2. 8 429006 AA443143 Hs. 50929 hypothetical protein FLJ13842 2. 8 434981 AW182577 Hs. 293077 ESTs 2. 8 437435 AA249439 Hs. 27027 hypothetical protein DKFZp762H1311 2. 8 442748 A1016713 Hs. 135787 ESTs 2. 8 443312 N52025 Hs. 46616 ESTs 2. 8 450940 Api744943 Hs. 143209 ESTs, Weakly similar to 138022 hypotheG 2. 8 452738 AL133800 Hs-7086 hypothetical protein MGC12435 2. 8 409182 AA064970 Hs. 118145 ESTs 2. 8 439793 AA018825 Hs. 7934 Kruppel-like factor 4 (gut) 2. 8 432683 AW995441 Hs. 10475 ESTs 2. 8 434269 AK001991 Hs. 3781 similar to murine leucine-rich repeat pr 2. 8 429500 X78565 Hs. 289114 hexabrachion (tenacin C, cytotæGn) 2. 8 433290 R20077 Hs. 302185 Homo sapiens clone 23618 mRNA sequence 2. 8 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 2. 8 435977 AL138079 Hs. 5012 brain. specific membrane-anchored protein 2. 8 430294 Api538226 Hs. 32976 guanine nucleotide binding protein 4 2. 8 425168 R96366 gb : yq37d04. s1 Soaresfetalliverspleen 2. 8 428180 AI129767 Hs. 182874 guanine nucleotide binding protein (G pr 2. 8 409348 A1401535 Hs. 146090 ESTs 2. 8 409887 AL137534 Hs. 56876 HomosapiensmRNA ; cDNADKFZp434H1419 (f 2. 8 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodiw 2. 8 430039 BE253012 Hs. 153400 ESTs, Weakly similar to ALU1HUMANALUS 2. 8 417642 BE302665 Hs. 105461 hypothetical protein FLJ20357 2. 8 419169 AW851980 Hs. 262346 ESTs, Weakly similar to S72482 hypothed Z8 434008 AA740878 Hs. 112982 ESTs 2. 8 446776 AW293417 Hs. 156455 ESTs 2. 8 408838 A1669535 Hs. 40369 ESTs 2. 8 422565 BE259035 Hs. 118400 singed (Drosophila)-like (sea urchin fas 2. 8 447397 BE247676 Hs. 18442 E-1 enzyme 2. 8 412530 AA766268 Hs. 266273 hypothetical protein FLJ13346 2. 8 424330 AW073953 Hs. 333396 Homo sapiens cDNA FW13596 fis, clone PL 2. 8 446377 AW014022 Hs. 170953 ESTs 2. 8 458924 BE242158 Hs. 24427 DKFZP56601646 protein 2. 8 447710 A1420523 Hs. 328241 ESTs 2. 8 404049 2. 8 416913 AW934714 gb : RC1-DT0001-03129gO11-a11 DT0001 Homo 2. 8 426400 M78361 Hs. 169743 Homo sapiens clone 25121 neuronal olfact 2. 8 413264 W26456 Hs. 134757 hypothetical protein FLJ20033 2. 8 458997 AW937420 Hs. 69662 ESTs 2. 7 422864 AA318323 gb : EST20390 Retina II Homo sapiens cDNA 2. 7 430526 AF181862 Hs. 242407 G protein-coupled receptor, family C, gr 2. 7 452023 AB032999 Hs. 27566 KIAAL 173 protein 2. 7 432022 AL162042 Hs. 272348 Homo sapiens mRNA ; cDNA DKFZp761 Li 212 (f 2. 7 452438 BE514230 Hs. 29595 JM4 protein 2. 7 435408 H07897 Hs. 4302 ESTs. Weakly similar to T29299 hypotheG 2. 7 418791 AA935633 Hs. 194628 ESTs 2. 7 438821 AA826425 Hs. 291829 ESTs 2. 7 423464 NM 016240 Hs. 128856 CSR1 protein 2. 7 442091 AW770493 Hs. 182874 guanine nucleoGde binding protein (G pr 2. 7 442242 AV647908 Hs. 90424 Homo sapiens cDNA : FL) fis, clone H 2. 7 412436 AA665089 gb : nu76dO1. sl NCl_CGAP_Aiv1 Homosapiens 2. 7 432821 BE170702 Hs. 279005 solute carrier family 21 (organic anion 2. 7 416404 AA180138 Hs. 107924 ESTs 2. 7 441364 AW450466 Hs. 126830 ESTs, Weakly similar to YD38 YEAST HYPOT 2. 7 450202 AW969756 Hs. 34145 ESTs, Weakly similar to 849647 GTP-bindi 2. 7 426304 AA374532 Hs. 124673 HomosapienscDNAFW11477fis, cloneHE 2. 7 428722 U76456 Hs. 190787 Gssue inhibitor of metalloproteinase 4 2. 7 449701 AW952323 Hs. 129908 KIAA0591 protein 2. 7 420372 AW960049 Hs. 293660 Homo sapiens, clone IMAGE : 3535476, mRNA, 2. 7 410318 AA084050 Hs. 269259 ESTs, Weakly similar to S23650 retroviru 2. 7 414603 R58394 Hs. 25119 ESTs, Weakly similar to YEXO YEAST HYPOT 2. 7 416096 H18577 Hs. 88974 cytochrome b-245, beta polypeptide (chro 2. 7 420896 AW149342 Hs. 24444 Homo sapiens cDNA : FLJ22165 fis, clone H 2. 7 424856 AA347746 Hs. 9521 ESTs, Weakly similar to ZN43_HUMAN ZINC 2. 7 436304 AA339622 Hs. 108887 ESTs 2. 7 441027 A1911412 Hs. 126444 ESTs 2. 7 452545 N31940 Hs. 14434 ESTs, Weakly similar to 138022 hypotheti 2. 7 454201 AB023191 Hs. 44131 KIAA0974 protein 2. 7 448560 BE613183 Hs. 23213 ESTs 2. 7 426807 AA385315 Hs. 156682 ESTs 2. 7 425825 Api929508 Hs. 159590 lymphocyte antigen 6 complex, locus H 2. 7 440351 AF030933 Hs. 7179 RAD1 (S. pombe) homolog 2. 7 425390 A1092634 Hs. 156114 protein tyrosine phosphatase, non-recept 2. 7 427624 AA406245 Hs. 24895 ESTs 2. 7 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 2. 7 422491 AA338548 Hs. 117546 neuronatin 2. 7 424560 AA158727 Hs. 150555 protein predicted by clone 23733 2. 7 432415 T16971 Hs. 289014 ESTs, Weakly similar to A43932 mucin 2 p 2. 7 414865 AA157155 Hs. 274414 hypothetical protein FLJ14457 2. 7 415827 H17462 Hs. 23079 ESTs 2. 7 445568 H00918 Hs. 268744 KIAA1796 protein 2. 7

433315 R96754 Hs. 239706 GRB2-associated binding protein 1 2. 7 428862 NM 000346 Hs. 2316 SRY (sex determining region Y)-box 9 (ca 2. 7 447959 Al452764 Hs. 270270 ESTs, Weakly similar to 2109260A B cell 2. 7 426420 8E383808 Hs. 322430 NDRG family, member 4 2. 7 436899 AA764852 Hs. 291567 ESTs 2. 7 444100 AA383343 Hs. 221 i6 CDC14 (cell division cycle 14, S. cerevi 2. 7 426501 AW043782 Hs. 293616 ESTs 2. 7 449092 U91641 Hs. 22985 alpha2, 8-sialyltransferase 2. 7 427311 AB020672 Hs. 175411 KIAA0865 protein 2. 7 453313 BE005771 Hs. 153746 hypothetical protein FLJ22490 2. 7 404029 2. 7 416289 W26333 Hs. 337438 ESTs 2. 7 439108 AW163034 Hs. 6467 synaptogyrin 3 2. 6 418746 At955289 Hs. 300759 ribosome protein L36 2. 6 412046 Y07847 Hs. 73088 RAS-related on chromsome 22 2. 6 435040 A1932350 Hs. 152825 ESTs 2. 6 453083 U87223 Hs. 31622 contain associated protein 1 2. 6 428167 AA770021 Hs. 16332 ESTs 2. 6 420028 AB014680 Hs. 8786 carbohydrate (N-acetylglucosamine-6-0) s 2. 6 443715 A1583187 Hs. 9700 cyclin E1 2. 6 421247 BE391727 Hs. 102910 general transcription factor IIH, polype 2. 6 424687 J05070 Hs. 151738 matrix metalloproteinase 9 (gelafinase B 2. 6 415056 AB004662 Hs. 77867 adenosine At receptor 2. 6 451697 AW449774 Hs. 296380 POM (POM121 rat homolog) and ZP3 fusion 2. 6 433701 AW445023 Hs. 15155 ESTs 2. 6 457358 A1479755 Hs. 129010 ESTs 2. 6 430347 NM_002039 Hs. 239706 GR82-associated binding protein 1 2. 6 418027 A8037807 Hs. 83293 hypothetical protein 2. 6 440491 R35252 Hs. 24944 ESTs, Weakly similar to 2109260A B cell 2. 6 425171 AW732240 Hs. 16365 ESTs 2. 6 459335 AW298545 Hs. 250726 EST 2. 6 425402 A1215881 Hs. 24970 ESTs, Weakly similar to 834323 GTP-bindi 2. 6 453169 AB037815 Hs. 32156 K1AA1394 protein 2. 6 433647 AA603367 Hs. 222294 ESTs 2. 6 450414 AI907735 Hs. 21446 KIAA1716 protein 2. 6 446233 A1282028 Hs. 25205 ESTs 2. 6 415446 F08898 Hs. 66075 ESTs 2. 6 445873 AA250970 Hs. 251946 poly (A)-binding protein, cytopiasmid-t 2. 6 413012 D83777 Hs. 75137 KIAA0193 gene product 2. 6 428671 BE297851 Hs. 189482 zinc finger protein 179 2. 6 427158 AA935603 Hs. 166231 ESTs 2. 6 408988 AL119844 Hs. 49476 Homo sapiens clone TUA8 Cri-du-chat regi 2. 6 459516 Al049662 Hs. 246858 EST 2. 6 402693 2. 6 408039 AA131424 Hs. 50340 ESTs 2. 6 422896 AW961489 Hs. 154116 ESTs 2. 6 423130 AW897586 Hs. 21213 ESTs 2. 6 438796 W67821 Hs. 109590 genethonin 1 2. 6 439871 R88518 Hs. 46736 hypothetical protein FU23476 2. 6 440192 AA872282 Hs. 190596 ESTs 2. 6 419708 AK000753 Hs. 92374 hypothetical protein 2. 6 449436 AA860329 Hs. 279307 hypothetical protein DKFZp43412117 2. 6 436870 AW204219 Hs. 155560 calnexin 2. 6 448424 AW009892 Hs. 31924 ESTs 2. 6 401324 2. 6 414136 AA812434 Hs. 119023 SMC2 (structural maintenance of chromoso 2. 6 433943 AA992805 Hs. 44865 lymphoid enhancer-binding factor 1 2. 6 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 2. 6 429139 F09092 Hs. 66087 ESTs 2. 6 423073 BE252922 Hs. 123119 MAD (mothers against decapentaplegic, Dr 2. 6 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding pmt 2. 6 444001 A1095087 Hs. 152299 ESTs, Moderately similar to S65657 alpha 2. 6 412049 N53437 Hs. 18268 adenylate kinase 5 2. 6 441783 BE313412 Hs. 7961 Homosapiensclone25012mRNAsequence 2. 6 425287 R88249 Hs. 155524 peanut (Drosophila)-like2 2. 6 432149 AW614326 Hs. 157022 ESTs, Weakly similar to T34549 probable 2. 6 452234 AW084176 Hs. 223296 ESTs, Weakly similar to 138022 hypotheG 2. 6 453478 AF083898 Hs. 33021 neuro oncologica'ventral anGgen 2 2. 6 418962 AA714835 Hs. 271863 ESTs 2. 6 418858 AW961605 Hs. 21145 hypothetical protein RG083M05. 2 2. 6 443257 A1334040 Hs. 11614 HSPC065 protein 2. 6 428748 AW593206 Hs. 98785 Ksp37 protein 2. 6 444984 H15474 Hs. 132898 fatty acid desaturase 1 2. 6 433404 T32982 Hs. 102720 ESTs 2. 6 434779 AF153815 Hs. 50151 potassium inwardly-rectifying channel, s 2. 6 420582 BE047878 Hs. 99093 Homo sapiens chromosome 19, cosmid R2837 2. 6 452856 AF034799 Hs. 30881 protein tyrosine phosphatase, receptor t 2. 6 436440 A1471862 Hs. 196008 Homo sapiens CDNA FU 11723 fis, clone HE 2. 6 438527 Api969251 Hs. 115325 RAB7, member RAS oncogene family-like 1 2. 6 433216 AF217412 Hs. 47320 neuroligin 3 2. 6 435380 AA679001 Hs. 192221 ESTs 2. 6 428966 AF059214 Hs. 194687 cholesterol 25-hydroxylase 2. 6 439653 AW021103 Hs. 6631 hypothetical protein FU20373 2. 6

419304 A1271326 Hs. 146101 ESTs, Weakly similar to T45070 protein k 2. 6 422991 H10940 Hs. 48965 Homo sapiens cDNA : FU21693 fis, clone C 2. 6 448548 R13209 Hs. 21413 solute camer family 12. (potassium-chl 2. 6 435370 A1964074 Hs. 225838 ESTs 2. 6 408875 NM_015434 Hs. 48604 DKFZP434B168 protein 2. 5 457005 AJ007421 Hs. 172597 sal (Drosophila)-like 3 2. 5 430154 AW583058 Hs. 234726 serine (or cysteine) proteinase inhibito 2. 5 438549 BE386801 Hs. 21858 tnnucleobde repeat containing 3 2. 5 427951 A1826125 Hs. 43546 ESTs 2. 5 411800 N39342 Hs. 103042 microtubule-associated protein 1B 2. 5 457683 Api821877 Hs. 140002 ESTs, Moderately similar to ALU7 HUMAN A 2. 5 451422 AB002336 Hs. 26395 erythrocyte membrane protein band 4. 1-li 2. 5 430713 AA351647 Hs. 2642 eukaryotic translation elongation factor 2. 5 428826 AL048842 Hs. 194019 attraction 2. 5 428963 AW382682 Hs. 258208 Homo sapiens, clone MGC : 15606, mRNA, com 2. 5 428141 D50402 Hs. 182611 solutecrierfamily11 (proton-coupled 2. 5 429550 AW293055 Hs. 119357 ESTs 2. 5 438662 AA223599 Hs. 6351 cleavage and polyadenylaGon specific fa 2. 5 435760 AF231922 Hs. 213004 chromosome 21 open reading frame 62 2. 5 427513 A1476318 Hs. 192480 ESTs 2. 5 430061 AB037817 Hs. 230188 KIAA1396 protein 2. 5 435923 BE301930 Hs. 5010 Homo sapiens clone 24672 mRNA sequence 2. 5 417123 BE326521 Hs. 159450 ESTs 2. 5 439699 AF086534 Hs. 187561 ESTs, Moderately simitar to ALU1HUMAN A 2. 5 412980 AI815750 Hs. 20977 hypothetical protein MGC3129 similar to 2. 5 427209 H06509 Hs. 92423 KIAA1566 protein 2. 5 424327 AA431707 Hs. 31209 ESTs 2. 5 436340 R42246 Hs. 21606 ESTs 2. 5 450650 T65617 Hs. 101257 hypothetical protein MGC3295 2. 5 439444 A1277652 Hs. 54578 ESTs. Weakly similar to 138022 hypotheG 2. 5 400777 2. 5 439478 AF049460 Hs. 6574 deformed epidermal autoregulatory factor 2. 5 450407 NM000810 Hs. 24969 gamma-aminobutydc acid (GABA) A recepto 2. 5 450385 A1631024 Hs. 24948 synuclein, alpha interacting protein (sy 2. 5 432558 R97268 Hs. 177269 ESTs 2. 5 400860 2. 5 410361 BE391804 Hs. 62661 guanylate binding protein t, interferon-2. 5 416063 BE047699 Hs. 93454 ESTs 2. 5 414998 NM 002543 Hs. 77729 oxidised low density lipoprotein (lecbn 2. 5 452823 AB012124 Hs. 30696 transcription factor-like 5 (basic helix 2. 5 417791 AW965339 Hs. 111471 ESTs 2. 5 418079 R40058 Hs. 6911 ESTs 2. 5 408495 W68796 Hs. 237731 ESTs 2. 5 442104 L20971 Hs. 188 phosphodiesterase 4B, cAMP-specific (dun 2. 5 437370 AL359567 Hs. 161962 Homo sapiens mRNA ; cDNA DKFZp547D023 (fr 2. 5 429803 W81489 Hs. 223025 RAB31, member RAS oncogene family 2. 5 424959 NM_005781 Hs. 153937 activated p21cdc42Hs kinase 2. 5 427413 BE547647 Hs. 177781 hypothetical protein MGC5618 2. 5 408955 BE315170 Hs. 8087 NAG-5 protein 2. 5 415261 T40928 Hs. 8346 ESTs 2. 5 415716 N59294 Hs. 179662 nucleosome assembly protein 1-like 1 2. 5 417873 BE266659 Hs. 293659 Homosapiens, SimilartoRIKENcDNAA430 2. 5 418388 R72332 Hs. 29258 HomosapienscDNAFLJ11364fis, cloneHE 2. 5 421002 AF116030 Hs. 100932 transcription factor 17 2. 5 423244 AL039379 Hs. 209602 ESTs, Weakly similar to ubiquitous TPR m 2. 5 423553 AA405635 Hs. 96854 ESTs, Weakly similar to DYLX HUMAN CYTOP 2. 5 427961 AW293165 Hs. 143134 ESTs 2. 5 428301 AW628666 Hs. 98440 ESTs, Weakly similar to 138022 hypotheG 2. 5 428508 BE252383 Hs. 184668 SBB131 protein 2. 5 428858 AA436760 gb : zv67d11. rt Soares total fetus Nb2HF8_ 2. 5 428943 AW086180 Hs. 37636 ESTs, Weakly similar to KIAA1392 protein 2. 5 432427 AL037630 Hs. 6638 Homo sapiens cDNA FW 11602 fis, clone HE 2. 5 435347 AW014873 Hs. 116963 ESTs 2. 5 437949 U78519 Hs. 41654 ESTs, Weakly similar to A46010 X-linked 2. 5 438208 AL041224 Hs. 65379 ESTs 2. 5 440286 U29589 Hs. 7138 cholinergic receptor, muscarinic 3 2. 5 441523 AW514263 Hs. 301771 ESTs, Weakly similar to ALUF HUMAN ! ! ! ! 2. 5 441805 AA285136 Hs. 301914 neurona) specific transcription factor D 2. 5 442337 AI371029 Hs. 129257 ESTs, Weakly similar to TC17_HUMAN TRANS 2. 5 442789 AW904361 Hs. 131191 ESTs. Weakly similar to ALU7 HUMAN ALU S 2. 5 445556 At910241 Hs. 12887 æon-elated protein 3-beta 2. 5 449086 A1628357 Hs. 208037 ESTs 2. 5 459583 A1907673 gb : lL-BT152-080399-004 BT152 Homo sapien 2. 5 TABLE 24B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408432 1058667_1 AW195262R27868AW811262 412225 1284108_1 AW902042N77591 412436 129439_1 AA665089 AA135130 AA484059 AA102419 AW877765

416120 1571266 1 H46739 H51513 H19779 416871 1626761 1 H98716 N90792 N24283 416913 163001_1 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 M190449 AW513465 BE161006 BE162499 422864 222336_1 M318323 H11145 R15289 M451945 M476690 M436954 Z43802 F11753 T65491 D81821 422949 223184_1 AA319435 N56456 AA319377 AW961532 T48452 AA894424 422977 223410_ 1 AA631498 A1017191 AA491211 AA761823 AA714555 AA768099 AA808286 AI934069 AA570223 AA574389 AA582438 AI745346 AW964510 AA319642 AW853758 H56414 423756 2317251 AA828125AA834883AA330555 425168 247552_1 R96366 AL133929 M351636 H78818 M477084 Z28957 H80194 425517 252729_1 AF121179BE162736M358827 426413 266650 1 AA377823 AW954494 A1022688 428002 285602 1 AA418703 AA418711 BE071915 BE071920 BE071912 428679 294049_1 AA431765 AA432015 428858 296453_1 M436760 AW237453 BE327496 N47347 N56967 429007 298301_1 D80642 M4U145 AL11901 5 AW904500 429163 3005431 AA884766AW974271AA592975AA447312 433532 368950_1 AW975367 M598607 M742735 436190 41555_1 AK001059M633055 437034 431713 1 AA742643 AA808575 AW976668 438458 457837_1 AW975186 M807807 D29548 438993 46765111 AA828995 AA834879 A1926361 439566 47387 1 AF086387 W77884 W72711 440322 491966_1 AA879430 BE070262 BE070493 BE070272 BE070484 BE070397 BE070395 BE070201 BE070198 BE070404 BE070270 BE070400 444584 611496 1 A1168422 D8011 T59074 447197 711623 1 R36075 A1366546 R36167 448451 764066 1 AW01599 R39898 AW000978 AI598202 AI521706 450625 84032_1 AW970107M513951 M010406 452453 918300 1 A1902519 A1902518 A1902516 454996 1248640J AW850180AW850326 455350 1283853 1 AW901809 AW901787 AW901795 AW901792 AW901744 AW901753 AW901807 AW901798 TABLE 24C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et al. * refers to the publication entitled'The DNA sequence of human chromosome 2r Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. NtposiGon : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 400777 8131663 Plus 7074571121 400780 8131663 Minus 118372-118619 400859 9757499 Minus 91888-92018. 98131-98294. 99474-99570 400860 9757499 Minus 151830-152104, 152649-152744 400992 8096828 Plus 140390-140822 401324 9863791 Plus 234057-234174 402408 9796239 Minus 110326-110491 402604 9909420 Plus 20393-20767 402605 9909420 Minus 47680-47973 402693 8569863 Minus 82366-82515 402855 9662953 Minus 59763-59909 404029 7671252 Plus 108716-111112 404048 3688074 Minus 54421-56808 404049 3688074 Minus 75765-78155 404283 2276311 Minus 99460-99564 404299 5738652 Minus 3826-4025 404541 8318559 Plus 103456-103664 404584 9857511 Plus 138651-139153 404593 9944086 Minus 74922-75788 404721 9856648 Minus 173763-174294 404819 4678240 Plus 16223-16319, 16427-16513, 1673&16859, 16941-17075, 1717a17287, i7389-17529, 18261-18357, 1844318578 405238 7249119 Minus 51728-51836 405771 7018349 Plus 91191-91254, 91510-91589 405819 4007557 Plus 2830-2967 406311 9211559 Minus 137114-139033 TABLE 25A : ABOUT 1202 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CENTRAL NERVOUS SYSTEM (CNS) Table 25A lists about 1202 genes up-regulated in glioblatoma compared to normal adult central nervous system (CNS). These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of'average'glioblastoma to'average' normal adult CNS tissues was greater than or equal to 2. 0. The'average* glioblastoma level was set to the 75 percenGle amongst various glioblastoma tumors. The'average'normal adult CNS tissue level was set to the 95"'percentile amongst various non-malignant tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10'"percenGle value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene UUe R1 : Ratio of 75t percenGle tumor to 95^ pencentile nommal adult nervous system tissue Pkey ExAccn UnigenelD Unigene Titie R1 452461 N78223 Hs. 108106 transcription factor 20. 1 436895 AF037335 Hs. 5338 carbonic anhydrase XII 15. 2 453941 U39817 Hs. 36820 Bloom syndrome 14. 2 443247 BE614387 Hs. 333893 c-Myc target JP01 12. 4

428330 L22524 Hs. 2256 matrixmetåloproteinase7 (matnlysin 12. 0 447342 A ! 199268 Hs. 19322 Homosapiens, SimilartoRlKENcDNA2OlO 11. 7 422163 AF027208 Hs. 112360 pmminin (mouseFlike1 114 439451 AF086270 Hs. 278554 heterochromatin-likeprotein 1 11. 2 424800 AL035588 Hs. 153203 MyoD family inhibitor 10. 2 416111 AA033813 Hs. 79018 chmmaUnassemblyfætor1subunitAt 10. 0 444190 Al878918 Hs. 10526 cysteine and glycine-rich protein 2 9. 9 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 9. 9 449340 AW235786 Hs. 195359 hypothetical protein MGC10954 9. 8 409731 AA125985 Hs. 56145 thymosin, beta, identified in neuroblast 9. 4 439978 BE139460 Hs. 124673 HomosapienscDNAFW11477fis, cloneHE 8. 9 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAA1330 protein 8. 9 456516 BE172704 Hs. 222746 KIAA1610 protein 8. 2 420092 AA814043 Hs. 88045 ESTs 7. 9 422631 BE218919 Hs. 118793 hypotheUcarproteinFW10638 7. 9 453392 U23752 Hs. 32964 SRY (sex determining region Yybox 11 7. 9 438527 AI969251 Hs. 115325 RAB7, member RAS oncogene family-like 1 7. 9 427581 NM 014788 Hs. 179703 KIAA0129 gene product 7. 8 418661 NM 001949 Hs. 1189 E2Ftranscriptionfactor3 7. 8 440684 Al253123 Hs. 127356 ESTs, Highly similar to S21424 nesfin (H 7. 8 429643 AA455889 Hs. 167279 FYVE-finger-containing Rab5 effector pro 7. 7 409638 AW450420 Hs. 21335 ESTs 7. 5 444665 BE613126 Hs. 47783 B aggressive tymphoma gene 7. 5 456759 BE259150 Hs. 127792 delta (Drosophilaplike3 7. 5 412777 A1335773 Hs. 270123 ESTs 7. 4 436607 AW661783 Hs. 211061 ESTs 7. 3 432058 AW665996 Hs. 130729 ESTs, Weakly similar to ALU1 HUMAN ALU S 7. 3 417061 Al675944 Hs. 188691 Homo sapiens cDNA FLJ12033 fis, clone HE 7. 3 428976 AL037824 Hs. 194695 ra homolog gene family, member 1 7. 2 433244 AB040943 Hs. 271285 KIAA1510 protein 7. 1 436726 AA324975 Hs. 128993 ESTs, Weakly similar to T00079 hypotheU 7. 1 408432 AW195262 gb : xn67bO5. xl NCI_CGAP_CML1 Homosapiens 7. 1 434164 AW207019 Hs. 148135 senneÅheonine kinae 33 7. 0 445873 AA250970 Hs. 251946 poly (A)-binding protein, cytoplasmic 1-l 7. 0 439726 AW449893 Hs. 293707 ESTs, Weakly similar to 138598 zinc fing 7. 0 432656 NM 000246 Hs. 3076 MHC class 11 transacbvator 6. 8 431117 AF003522 Hs. 250500 delta (Drosophila)-like 1 6. 8 453387 A1990741 Hs. 252809 ESTs 6. 8 418821 AA436002 Hs. 183161 ESTs 6. 6 437034 AA742643 gb : ny91c01. sl NCI_CGAP_GCB1 Homosapiens 6. 6 411252 AB018549 Hs. 69328 MD-2 protein 6. 5 424687 J05070 Hs. 151738 matrix metalloproteinase 9 (gelatinase B 6. 4 452953 At932884 Hs. 271741 ESTs, Weakly similar to A46010 X-linked 6. 3 433532 AW975367 gb : EST387475 MAGE resequences, MAGN Homo 6. 3 420311 AW445044 Hs. 38207 HumanDNAsequencefromcloneRP4530115 6. 3 418097 R45137 Hs. 21868 ESTs 6. 2 407304 AA565832 gb : nj32bO3. sl NCI CGAP_A1 Homoosapiens 6. 2 435256 AF193766 Hs. 13872 cytokine-like protein C17 6. 1 449448 D60730 Hs. 57471 ESTs 6. 1 403790 6. 0 425517 AF121179 gb : AF121179Homosapiensliver (ChangL-6. 0 420674 NM000055 Hs. 1327 butyrylcholinesterase 6. 0 435542 AA687376 Hs. 269533 ESTs 5. 9 418216 AA662240 Hs. 283099 AF15q14 protein 5. 8 439086 AF085947 gb : Homo sapiens full length insert cDNA 5. 8 408037 AW271720 Hs. 42233 hypotheGcal protein FLJ10300 5. 7 412225 AW902042 gb : QVO-NN1022-170400-193cO2NN1022Homo 5. 7 436109 AA922153 Hs. 132760 hypotheticalprotein MGC15729 5. 7 435005 U80743 Hs. 306094 trinucleotide repeat containing 12 5. 7 429149 AW193360 Hs. 197962 ESTs, Weakysimilartol38022hypotheU 5. 7 418113 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 5. 6 405558 5. 6 442432 BE093589 Hs. 38178 hypothetical protein FU23468 5. 6 442547 AA306997 Hs. 217484 ESTs, Weakly similar to ALU1_HUMAN ALU S 5. 6 413063 AL035737 Hs. 75184 chitinase 3-like 1 (cartilage glycoprote 5. 5 420560 AW207748 Hs. 59115 ESTs 5. 5 408096 BE250162 Hs. 83765 dihydrofolate reductase 5. 5 443539 A1076182 Hs. 134074 ESTs, Moderately similar to ALU6 HUMAN A 5. 4 426318 AA375125 Hs. 147112 HomosapienscDNA : FU22322 fis, clone H 5. 4 429115 AA446728 Hs. 289020 Homo sapiens cDNA FLJ 14098 fis, clone MA 5. 3 453900 AW003582 Hs. 226414 ESTs, Weakly similar to ALU8_HUMAN ALU S 5. 3 444168 AW379879 gb : RC1-HT0256-081199-011-fOlHT0256Homo 5. 3 432789 D26361 Hs. 3104 KIAA0042 gene product 5. 3 437036 A1571514 Hs. 133022 ESTs 5. 2 421247 BE391727 Hs. 102910 general transcription factor IIH, polype 5. 2 441523 AW514263 Hs. 301771 ESTs, Weakly similar to ALUF HUMAN ! ! ! ! 5. 2 451106 BE382701 Hs. 25960 v-myc avian myelocytomatosis viral relat 5. 1 457211 AW972565 Hs. 32399 ESTs Weakly similar to S51797 vasodilat 5. 1 454157 AW162906 Hs. 312481 ESTs Weakly similar to S66668 hydrogen 5. 1 423343 AA324643 Hs. 246106 ESTs 5. 1 425292 NM005824 Hs. 155545 37 kDa leucine-rich repeat (LRR) protein 5. 1 406679 AA070786 gb : zm66bO7. rl Stratageneneuroepithelium 5. 1 442671 Al005668 Hs. 134779 EST 5. 1

433001 AF217513 Hs. 279905 clone HQ0310 PR00310p1 5. 0 418819 AA228776 Hs. 191721 ESTs 5. 0 432946 U60899 Hs. 279854 mannosidase, alpha, class 2B, member 1 4. 9 420730 NM002691 Hs. 99890 polymerase (DNA directed), delta 1, cata 4. 9 441217 A1922183 Hs. 213246 ESTs 4. 9 453385 AW296101 Hs. 252806 ESTs 4. 8 418203 X54942 Hs. 83758 CDC28 protein kinase 2 4. 7 450813 A1739625 Hs. 203376 ESTs 4. 7 444006 BE395085 Hs. 10086 type I transmembrane protein Fn14 4. 7 412530 AA766268 Hs. 266273 hypothetical protein FLJ13346 4. 7 431070 AW408164 Hs. 249184 transcription factor 19 (SC1) 4. 7 429786 AL080232 Hs. 220696 Homo sapiens mRNA ; cDNA DKFZp586A061 (fr 4. 7 405771 4. 6 457065 A1476318 Hs. 192480 ESTs 4. 6 436190 AK001059 gb : Homo sapiens cDNA FW 10197 fis, clone 4. 6 400859 4. 6 435267 N23797 Hs. 110114 ESTs 4. 6 443454 Al057494 Hs. 133421 ESTs 4. 5 452811 AA937079 Hs. 118983 hypotheticalprotein FLJ12150 4. 5 437267 AW511443 Hs. 258110 ESTs 4. 5 435020 AW505076 Hs. 301855 DiGeorge syndrome critical region gene 8 4. 5 454269 A1961060 Hs. 129908 KIAA0591 protein 4. 5 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 4. 5 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur 4. 5 456534 X91195 Hs. 100623 phospholipase C, beta 3, neighbor pseudo 4. 5 423756 AA828125 gb : od7) a09. s1NaCGAPOv2 Homo sapiens 4. 5 417308 H60720 Hs. 81892 KIAA0101 gene product 4. 5 422170 A1791949 Hs. 112432 anti-Mullerian hortnone 4. 4 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotacGn) 4. 4 406568 AF088886 Hs. 11590 cathepsin F 4. 4 426812 AF105365 Hs. 172613 solutecarierfamily12 (potasium/chlo 4. 4 402516 4. 4 432865 A1753709 Hs. 152484 ESTs, Weakly similar to 138022 hypotheti 4. 4 413625 AW451103 Hs. 71371 ESTs 4. 4 436098 R20597 Hs. 9739 glycerol-3-phosphatedehydrogenae 1 (so 4. 4 418333 W92113 gb : zh48eO1. r1 Soaes_fetalJiver_spleen_ 4. 4 416933 BE561850 Hs. 80506 smallnuclearribonucleoproteinpolypept 4. 4 438192 Api859065 Hs. 337620 HomosapiensAFG3LlisofommimRNA, part 4. 3 457374 AA493662 gb : nhOSdl2. sl NCl_CGAP_Thyl Homosapiens 4. 3 433159 AB035898 Hs. 150587 kinesin-like protein 2 4. 3 444386 BE065183 gb : RCi-BT0314-020200-012-c04 BT0314 Homo 4. 3 453202 AW085781 Hs. 26270 hypotheGcalproteinFW11588 4. 3 441020 W79283 Hs. 35962 ESTs 4. 3 414733 BE514535 Hs. 77171 minichromosome maintenance deficient (S. 4. 3 407902 AL117474 Hs. 41181 Homo sapiens mRNA ; cDNA DKFZp727C191 (fr 4. 3 405701 4. 3 451659 BE379761 Hs. 14248 ESTs 4. 3 418845 AA852985 Hs. 89232 chromobox homolog 5 (Drosophila HP1 alph 4. 2 433323 AA805132 Hs. 30701 ESTs 4. 2 439811 AA135332 Hs. 71608 ESTs 4. 2 415406 T26510 gb : AB282F8R Infant brain, LLNL array of 4. 2 436282 R91913 Hs. 272104 ESTs, Moderately similar to ALU1 HUMAN A 4. 1 441269 AW015206 Hs. 178784 ESTs 4. 1 418727 AA227609 Hs. 94834 ESTs 4. 1 433006 BE242758 Hs. 190223 ESTs, Moderately similar to T29285 hypot 4. 1 436480 AJ271643 Hs. 87469 putaGve æid-sensing ion channel 4. 1 430786 AA486144 Hs. 31293 ESTs 4. 1 445372 N36417 Hs. 144928 ESTs 4. 1 410555 U92649 Hs. 64311 a disintegrin and metalloproteinase doma 4. 0 457465 AW301344 Hs. 122908 DNA replication factor 4. 0 422094 AF129535 Hs. 272027 F-box only protein 5 4. 0 442029 AW956698 Hs. 14456 neural precursor cell expressed, develop 4. 0 459321 AW044477 Hs. 299538 ESTs 4. 0 421308 AA687322 Hs. 192843 leucinezipperproteinFKSG14 4, 0 420567 AK000812 Hs. 98874 similar to proline-rich protein 48 4. 0 447004 AW296968 Hs. 157539 ESTs 4. 0 448295 A1381911 Hs. 334859 KIAA1814protein 3. 9 439699 AF086534 Hs. 187561 ESTs, Moderately similar to ALU1 HUMAN A 3. 9 440704 M69241 Hs. 162 insulin-like growth factor binding prote 3. 9 453096 AW294631 Hs. 11325 ESTs 3. 9 457026 AA397620 Hs. 48692 ESTs 3. 9 404642 3. 9 450375 AA009647 Hs. 8850 a disintegrin and metalloproteinase doma 3. 9 430132 AA204686 Hs. 234149 hypothetical protein FU20647 3. 9 437718 A1927288 Hs. 196779 ESTs 3. 9 438490 AW593272 Hs. 301299 ESTs 3. 9 429919 AA460692 Hs. 278945 hypothetical protein FLJ23024 3. 9 413604 R51767 gb : yg73g1 1. r1 Soares infant brain 1N ! BH 3. 9 425599 AW366745 Hs. 214140 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 9 448796 AA147829 Hs. 301431 endothelial zinc finger protein induced 3. 9 449300 A1656959 Hs. 222165 ESTs 3. 8 452203 X57522 Hs. 158164 transporter 1, ATP-binding cassette, sub 3. 8 425769 U72513 Hs. 159486 Human RPL13 2 pseudogene mRNA, complete 3. 8

404295 3. 8 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-3. 8 428728 NM016625 Hs. 191381 hypothetical protein 3. 8 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 3. 8 430172 AA468591 Hs. 161889 ESTs 3. 8 447499 AW262580 Hs. 147674 protocadherin beta 16 3. 8 405884 3. 8 437236 AW137817 Hs. 244353 ESTs 3. 7 418883 BE387036 Hs. 1211 acid phosphatase 5, tartrate resistant 3. 7 444143 AW747996 Hs. 160999 ESTs, Moderately similar to A56194 throm 3. 7 425529 NM_014656 Hs. 158282 KIAA0040 gene product 3. 7 425502 R98895 Hs. 125823 ESTs 3. 7 419741 NM_007019 Hs. 93002 ubiquiGncamerpmteinE2^C 3. 7 402424 3. 7 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxylaGng ; 3. 7 434072 H70854 Hs. 283059 Homo sapiens PR01082 mRNA, complete cds 3. 7 414872 U82010 Hs. 77513 COX10 (yeast) homolog, cytochrome c oxid 3. 7 426071 AW138057 Hs. 163835 ESTs 3. 7 419078 M93119 Hs. 89584 insulinoma-associated 1 3. 7 428037 N47474 Hs. 89230 potassium intermediate/small conductance 3. 7 416547 H62914 Hs. 268946 ESTs, WeaklysimilartoPC4259fembn 3. 7 436899 AA764852 Hs. 291567 ESTs 3. 6 436722 AW975977 gb : EST388086 MAGE esequences, MAGN Homo 3. 6 440652 Api216751 Hs. 143977 ESTs 3. 6 428450 NM_014791 Hs. 184339 KIAA0175 gene product 3. 6 452103 R42764 Hs. 339654 ESTs, Weakly similar to 138022 hypotheti 3. 6 409048 H59990 Hs. 37699 ESTs 3. 6 439546 AF088056 gb : Homo sapiens full length insertcDNA 3. 6 443544 A1076315 Hs. 16359 ESTs 3. 6 418478 U38945 Hs. 1174 cyclin-dependent kinase inhibitor 2A (me 3. 6 435889 A1249107 Hs. 269901 ESTs 3. 6 420301 AA767526 Hs. 22030 paired box gene 5 (B-cell lineage specif 3. 6 438078 A1016377 Hs. 131693 ESTs 3. 6 408420 NM_006915 Hs. 44766 retinitis pigmentosa 2 (X-linked recessi 3. 6 416871 H98716 gb : yx13d08. s1 Soares melanocyte 2NbHM Ho 3. 5 424085 NM 002914 Hs. 139226 replication factor C (activator 1) 2 (40 3. 5 446291 BE397753 Hs. 14623 interferon, gamma-inducible protein 30 3. 5 432281 AK001239 Hs. 274263 hypothetical protein FLJ10377 3. 5 436123 AA057484 Hs. 35406 ESTs, Highly similar to unnamed protein 3. 5 411256 AW834039 gb : QVO-TT0010-091199-053-eO9TT0010Homo 3. 5 419239 AA468183 Hs. 184598 HomosapienscDNA : FLJ23241 fis, clone C 3. 5 435065 BE064391 gb : RC4-BT0310-110300-015-bO8BT0310Homo 3. 5 435532 AW291488 Hs. 117305 Homo sapiens, clone IMAGE : 3682908, mRNA 3. 5 447101 N72185 Hs. 44189 ESTs 3. 5 410530 M25809 Hs. 64173 ATPase, H transporting, lysosomal (vacu 3. 5 422156 N34524 gb : yy56d10. s1 Soaes_mulEple_sclerosis_ 3. 5 453616 NM003462 Hs. 33846 dynein, axonemal, light intermediate pol 3. 5 439743 AL389956 Hs. 283858 Homo sapiens mRNA full length insert cDN 3. 5 453884 AA355925 Hs. 36232 KlM0186geneproduct 3. 5 424954 NM-000546 HS. IM tumor protein p53 (Li-Fraumeni syndrome) 3. 5 420721 AA927802 Hs. 159471 ZAP3 protein 3. 5 426764 AA732524 Hs. 151464 ESTs, Weakly similar to ALUC_HUMAN ! ! ! ! 3. 4 420649 Al866964 Hs. 124704 ESTs, Moderately similar lo S65657 a'pha 3. 4 448831 AL080123 Hs. 22182 zinc finger protein 23 (KOX 16) 3. 4 444371 BE540274 Hs. 239 forkhead box M1 3. 4 402604 3. 4 442407 AW469584 Hs. 32353 mitogen-activated protein kinase kinase 3. 4 414300 A1304870 Hs. 188680 ESTs 3. 4 444670 H58373 Hs. 332938 hypothetical protein MGC5370 3. 4 414550 BE379808 gb : 601159567T1 NlH_MGC_53Homosapiensc 3. 4 452211 A1985513 Hs. 233420 ESTs 3. 4 414416 AW409985 Hs. 76084 hypothetical protein MGC2721 3. 4 449961 AW265634 Hs. 133100 ESTs 3. 4 413257 BE075035 gb : PM3-BT0584-260300-002-05 BT0584 Homo 3, 4 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 3. 4 417404 NM_007350 Hs. 82101 pleckstrin homology-like domain, family 3. 4 422846 BE513934 Hs. 1583 neutrophilcytosoticfætorl (47kD, chr 3. 4 446189 H85224 Hs. 214013 ESTs 3. 4 437385 AA757055 Hs. 164060 ESTs 3. 4 453652 AW009640 Hs. 28368 ESTs, Moderately similar to S65657 alpha 3. 4 408298 Api745325 Hs. 271923 Homo sapiens cDNA : FU22785 fis, clone K 3. 4 455778 BE088746 gb : CM2-BT0693-210300-123-dO9 BT0693 Homo 3. 3 417546 H65569 Hs. 18845 ESTs 3. 3 412471 M63193 Hs. 73946 endothelial cell growth factor 1 (platel 3. 3 454631 AW811324 gb : lL3-ST0141-131099-017-A02ST0141 Homo 3. 3 454294 AB000734 Hs. 50640 JAK binding protein 3. 3 457131 AC002310 Hs. 301463 Human Chromosome 16 BAC clone CIT987SK-A 3. 3 410102 AW248508 Hs. 279727 Homo sapiens cDNA 4035fis. done HE 3. 3 449676 AW380579 Hs. 209657 ESTs 3. 3 436211 AK001581 Hs. 334828 hypothetical potein FLJ107t9 ; KIAAi794 3. 3 453746 AL120611 gb : DKFZp761H119_r1761 (synonym : hamy2) 3. 3 452799 A1948829 Hs. 213786 ESTs 3. 3 435380 AA679001 Hs. 192221 ESTs 3. 3

426746 J03626 Hs. 2057 uridine monophosphate synthetase (orotat 3. 3 453362 H14988 Hs. 107375 ESTs 3. 3 456473 Al202788 Hs, 25682 Homo sapiens mRNA for KIAA1863 protein, 3. 3 416426 AA180256 Hs. 210473 Homo sapiens cDNA FLJ 14872 fis, clone PL 3. 3 445777 A1580371 Hs. 145384 ESTs 3. 3 423757 AL049337 Hs. 132571 Homo sapiens mRNA ; DNA DKFZp564POl 6 (fr 3. 3 431941 AK000106 Hs. 272227 Homo sapiens cDNA FU20099 fis, clone CO 3. 3 404299 3. 3 404108 3. 3 425189 H16622 gb : ym26cO7. rl Soares infant brain I NIB H 3. 3 449318 AW236021 Hs. 78531 Homo sapiens. Similar to RIKEN cDNA 5730 3. 3 450193 Al916071 Hs. 15607 Homo sapiens Fanconi anemia complemental 3. 2 427725 U66839 Hs. 180533 mitogen-activated protein kinase kinase 3. 2 424051 AL110203 Hs. 138411 Homo sapiens mRNA ; cDNA DKFZp586J 1922 (f 3. 2 418968 NM000078 Hs. 89538 cholesteryl ester transfer protein, plas 3. 2 449248 M33782 Hs. 23391 Homo sapiens, Similar to transcription f 3. 2 439416 W58294 Hs. 56254 ESTs 3. 2 401596 AA172106 Hs. 110950 Rag C protein 3. 2 408380 AF123050 Hs. 44532 diubiquitin 3. 2 450325 A1935962 Hs. 26289 ESTs 3. 2 428730 AA625947 Hs. 25750 ESTs 3. 2 457536 AA305233 Hs. 278712 eukaryotic translation initiation factor 3. 2 426836 N41720 Hs. 172684 vesicle-associated membrane protein 8 (e 3. 2 442710 A1015631 Hs. 23210 ESTs 3. 2 435232 NM 001262 Hs. 4854 cyclin-dependent kinase inhibitor 2C (pi 3. 2 430970 A1018210 Hs. 144083 ESTs 3. 2 416192 NM 005036 Hs. 998 peroxisome proliferaGve activated recep 3. 2 446676 H09380 Hs. 300965 ESTs 3. 2 451459 A1797515 Hs. 270560 ESTs, Moderately similar to ALU7_HUMAN A 3. 2 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, 3. 2 413840 A1301558 Hs. 146381 RNA binding motif protein, X chromosome 3. 2 448751 BE551203 Hs. 201792 ESTs 3. 2 432593 AW301003 Hs. 51483 ESTs, Weakly similar to hypothetical pro 3. 2 458786 A1457098 Hs. 280848 ESTs 3. 2 455909 BE156417 Hs. 278798 ESTs 3. 2 419311 AA689591 gb : nv66a12. s1NCiCGAPGCB1Homosapiens 3. 2 439710 AF086543 gb : Homo sapiens full length insert cDNA 3. 2 434559 AF147315 gb : Homo sapiens full length insert CDNA 3. 1 455800 R22479 Hs. 167073 Homo sapiens cDNA FU13047 fis, clone NT 3. 1 436703 AW880614 Hs. 146381 RNA binding motif protein, X chromosome 3. 1 414799 Api752416 Hs. 77326 insulin-like growth factor binding prote 3. 1 437860 AA333063 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 3. 1 434182 W20309 Hs. 118520 G-proteingamma-12subunit 31 417900 BE250127 Hs. 82906 CDC20 (cell division cycle 20, S. cerevi 3. 1 434769 AA648884 Hs. 134278 Homo sapiens cDNA FW12676 fis, clone NT 3. 1 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 3. 1 426413 AA377823 gb : EST90805 Synovial sarcoma Homo sapien 3. 1 447959 A1452784 Hs. 270270 ESTs, Weakly similar to 2109260A B cell 3. 1 404589 3. 1 421764 Al681535 Hs. 148135 serinelthreonine kinase 33 3. 1 419986 Ai345455 Hs. 78915 GA-binding protein transcription factor, 3. 1 416941 BE000150 Hs. 48778 niban protein 3. 1 414761 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homolog2 3. 1 449611 Api970394 Hs. 197075 ESTs 3. 1 434746 AA648368 Hs. 295368 ESTs 3. 1 434274 AA628539 Hs. 116252 ESTs, Moderaely similar to ALU1_HUMAN A 3. 1 427899 AA829286 Hs. 332053 serum amyloid At 3. 1 417642 BE302665 Hs. 105461 hypotheticalprotein FU20357 3. 1 452472 AW957300 Hs. 294142 ESTs, Weakly similar to C55663 oligodend 3. 1 446131 NM 000929 Hs. 290 phospholipaeA2, groupV 3. 1 440052 Api633744 Hs. 195648 ESTs, Weakly similar to 138022 hypotheti 3. 1 426531 AA381071 gb : EST94100AcEvatedT-ceilsXIIHomos 3. 1 422158 L10343 Hs. 112341 protease inhibitor 3, skin-derived (SKAL 3. 1 406267 3. 1 447039 AV661798 Hs. 282915 ESTs 3. 1 404802 3. 1 406927 M26460 gb : Homo sapiens (clone 104) reGnoblato 3. 1 419314 AW971924 Hs. 87280 ESTs 3. 0 435894 A1076667 Hs. 188011 ESTs 3. 0 432140 AK000404 Hs. 272688 hypothetical protein FLJ20397 3. 0 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 3. 0 425202 AW962282 Hs. 152049 ESTs, Weakty simitar to 138022 hypotheti 3. 0 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 3. 0 418241 M26682 Hs. 1149 LlMdomainonly1 (rhomboGn1) 3. 0 446599 Z97832 Hs. 15476 differentiattyexpressed in FDCP (mouse 3. 0 412950 BE018581 Hs. 245342 hypothetical protein FU14642 3. 0 428670 AA431682 Hs. 134832 ESTs 3. 0 446975 BE246446 Hs. 16695 ubiquitin-activating enzyme E1-like 3. 0 437756 AA767537 Hs. 197096 ESTs 3. 0 416084 L16991 Hs. 79006 deoxythymidylate kinase (thymidylate kin 3. 0 402374 AL135225 Hs. 301865 dopachrome tautomerase (dopachrome delta 3. 0 443885 H91806 Hs. 15284 ESTs 3. 0 434008 AA740878 Hs. 112982 ESTs 3. 0

452568 AA805634 Hs. 300870 Homo sapiens mRNA ; cDNA DKFZp547M072 (fr 3. 0 414239 A1288330 Hs. 182330 ESTs 3. 0 421013 M62397 Hs. 1345 mutated in colorectal cancers 3. 0 424635 AA420687 Hs. 115455 HomosapienscDNAFW14259fis, clonePL 3. 0 410276 A1554545 Hs. 68301 ESTs 3. 0 433865 N29862 Hs. 44104 ESTs 3. 0 406028 3. 0 401626 3. 0 415949 H10562 Hs. 21691 ESTs 3. 0 418583 AA604379 Hs. 86211 hypothetical protein 3. 0 417933 X02308 Hs. 82962 thymidylate synthetase 3. 0 434577 R37316 Hs. 179769 HomosapienscDNA : FLJ22487 fis, clone H 3. 0 430437 A1768801 Hs. 169943 Homo sapiens cDNA FLJ13569 fis, clone PL 3. 0 427940 AA417812 Hs. 38775 ESTs 2. 9 456060 C14904 Hs. 45184 Homo sapiens DNA FLJ12284 fis, clone MA 2. 9 421988 AW450481 Hs. 161333 ESTs 2. 9 448775 AB025237 Hs. 388 nudix (nucleoside diphosphate linked moi 2. 9 438598 Api805943 Hs. 326067 hypothetical protein MGC5178 2. 9 429612 AF062649 Hs. 252587 pituitary tumor-transforming 1 2. 9 451189 AA016019 Hs. 40905 ESTs 2. 9 401558 2. 9 426207 BE390657 Hs. 30026 HSPC182 protein 2. 9 404721 2. 9 401384 2. 9 417288 Api984792 Hs. 108812 hypothetical protein FU22004 2. 9 427648 At376722 Hs. 180062 proteasome (prosome, macropain) subunit, 2. 9 435928 H64345 Hs. 183961 ESTs 2. 9 431740 N75450 Hs. 183412 ESTs, ModeratelysimilartoAF11672167 2. 9 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 2. 9 439972 A1348100 Hs. 124662 ESTs 2. 9 433112 AA973801 Hs. 144553 ESTs, Weakly similar to unnamed protein 2. 9 423751 AW235633 Hs. 46525 ESTs 2. 9 406748 AW339106 Hs. 217493 annexin A2 2. 9 422154 T79045 Hs. 126927 ESTs 2. 9 405588 2. 9 440911 AA909536 Hs. 143562 ESTs 2. 9 412420 AL035668 Hs. 73853 bone morphogenetic protein 2 2. 9 445043 AW014413 Hs. 196066 ESTs 2. 9 410114 AW590540 Hs. 271280 ESTs 2. 9 419217 AA504571 gb : aa60e12. r1 NCI_CGAP_GC81 Homo sapiens 2. 9 415849 R20529 Hs. 6806 ESTs 2. 9 448140 AF146761 Hs. 20450 BCM-like membrane protein precursor 2. 9 453331 A1240665 Hs. 8895 ESTs 2. 9 432065 AA401039 Hs. 2903 protein phosphatase 4 (formerly X), cata 2. 9 438380 T06430 Hs. 6194 chondroiGn sulfate proteoglyean BEHAB/b 2. 9 454377 AA076811 gb : 7803Cl2 Chromosome 7 Fetal Brain cDNA 2. 9 421491 H99999 Hs. 42736 ESTs 2. 9 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7, S. cerevisi 2. 8 415446 F08898 Hs. 66075 ESTs 2. 8 439518 W76326 gb : zd60dO4. r1 Soares fetal_heart_NbHH19W 2. 8 427221 L15409 Hs. 174007 von Hippel-Lindau syndrome 2. 8 422493 AW474183 Hs. 250173 hypothetical protein FLJ 13158 2. 8 419451 Al907117 Hs. 90535 syntaxin binding protein 2 2. 8 448789 BE539108 Hs. 22051 hypothetical protein MGC15548 2. 8 424126 AA335635 Hs. 96917 ESTs 2. 8 458695 AV660159 Hs. 282284 ESTs, Weakly similar to 138022 hypotheti 2. 8 418973 AA233056 Hs. 191518 ESTs 2. 8 440471 AA886146 Hs. 307944 ESTs 2. 8 421016 AA504583 Hs. 101047 Vanscription (actor 3 (E2A immunoglobul 2. 8 433647 AA603367 Hs. 222294 ESTs 2. 8 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 2. 8 421723 AA620400 Hs. 300717 sodium channel, voltage-gated, type tit. 2. 8 434964 A1638850 Hs. 130746 ESTs 2. 8 432022 AL162042 Hs. 272348 Homo sapiens mRNA ; cDNADKFZp761L1212 (f 2. 8 400517 AF242388 Hs. 149585 lengsin 2. 8 433023 AW864793 Hs. 87409 thrombospondin 1 2. 8 448734 BE614070 Hs. 326416 Homo sapiens mRNA : cONA OKFZp564H1916 (f 2. 8 406736 Al254733 Hs. 182426 6bosomal protein S2 2. 8 409207 AW373564 Hs. 194637 BANP homolog, SMARt homolog 2. 8 440196 N72847 Hs. 125221 ESTs 2. 8 403961 2. 8 425193 AW965689 Hs. 22509 ESTs 2. 8 425268 Api807883 Hs. 180059 Homo sapiens cDNA FU20653 fis, clone KA 2. 8 440483 A1200836 Hs. 150386 ESTs 2. 8 412391 AW947710 gb : RCO-MT0004-130300-011-e07MT0004Homo 2. 8 448769 N66037 Hs. 38173 ESTs 2. 8 411632 AW854829 gb : QV2-CT0261-201099-011-f01CT0261Homo 2. 8 438221 A1798853 Hs. 122224 ESTs, Weakiy similar to ALUS HUMAN ALU S 2. 8 457578 AA578027 gb : nl20hO1. sl NCI_CGAP_HSC1 Homo sapiens 2. 8 455510 AA422029 Hs. 143640 ESTs, Weaklysimilartohyperpolaizatio 2. 8 447769 AW873704 Hs. 320831 Homo sapiens cDNA FW14597 hs, clone NT 2. 8 427701 AA411101 Hs. 243886 nuclear autoantigenic sperm protein (his 2. 8 433800 A1034361 Hs. 135150 lung type-) cell membrane-associated gly 2. 8

439662 H97552 Hs. 269060 ESTs 2. 8 425694 U51333 Hs. 159237 hexokinase 3 (white cell) 2. 8 414747 U30872 Hs. 77204 centromere protein F (350/400kD, mitosin 2. 8 414598 A1094221 Hs. 135150 lung type. l cell membrane-associated gly 2. 8 447752 M73700 Hs. 105938 tactotransferrin 2. 8 408761 AA057264 Hs. 238936 ESTs, Weakly similar to (define not ava 2. 8 453350 A1917771 Hs. 61790 hypothetical protein FLJ23338 2. 7 456629 AW891965 Hs. 279789 histone deacetylae 3 2. 7 439538 AA837323 Hs. 164047 ESTs 2. 7 458814 Al498957 Hs. 170861 ESTs, Weakly similar to 1195_HUMAN ZINC 2. 7 456029 BE255990 Hs. 218329 hypothetical protein 2. 7 451129 BE072881 gb : RC2-BT0548-200300-012-eO9 BTOW Homo 2. 7 456412 AW749617 Hs. 280776 tankyrase, TRF1-interacting ankyrin-rela 2. 7 453536 AA137000 Hs. 62578 ESTs 2. 7 438378 AW970529 Hs. 86434 hypothetical protein FU21816 2. 7 425745 U44060 Hs. 14427 Homo sapiens cONA : FLJ21800 fis, clone H 2. 7 446322 N23033 Hs. 155814 ESTs 2. 7 451592 A1805416 Hs. 213897 ESTs 2. 7 429466 M85835 Hs. 12827 ESTs 2. 7 429747 M87507 Hs. 2490 caspae 1, apoptosis-elated cysteine pr 2. 7 455514 AW983871 gb : RCI-HND003-220300-021-hO7 HN0003 How 2. 7 414732 AW410976 Hs. 77152 minichromosome maintenance deficient (S. 2. 7 444207 AI565004 Hs. 79572 cathepsin D (lysosomad aspartyl protease 2. 7 427421 AA402414 Hs. 3059 coatomer protein complex, subunit beta 2. 7 449655 A1021987 Hs. 59970 ESTs 2. 7 422648 D86983 Hs. 118893 Melanomaassociatedgene 2. 7 428494 AA233439 Hs. 184634 hypothetical protein FU20005 2. 7 406895 X60648 Hs. 172550 polypyhmidine tract binding protein (he 2. 7 453255 AA278167 Hs. 19215 Homo sapiens, clone IMAGE : 3605822, mRNA 2. 7 427348 NM014137 Hs. 177258 PR00650 protein 2. 7 435370 A1964074 Hs. 225838 ESTs 2. 7 407862 BE548267 Hs. 50724 Homo sapiens cDNA FU10934 fis, clone OV 2. 7 411874 AA096106 Hs. 20403 ESTs 2. 7 421192 AA833718 Hs. 204529 KlM1806protein 2. 7 435899 W89093 Hs. 189914 ESTs 2. 7 414603 R58394 Hs. 25119 ESTs, Weakly similar to YEXO YEAST HYPOT 2. 7 453462 AL037291 Hs. 236605 ESTs, Moderately similar to ALU4_HUMAN A 2. 7 436554 A1985810 Hs. 301173 ESTs 2. 7 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 2. 7 403881 2. 7 431779 AW971178 Hs. 268571 apolipoproteinC-I 2. 7 404984 2. 7 448275 BE514434 Hs. 20830 kinesin-like 2 2. 7 446839 BE091926 Hs. 16244 mitotic spindle coiled-coil elated prot 2. 7 411927 BE274009 Hs. 772 g) ycogensynthasel (musde) 2. 7 404756 2. 7 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 2, 7 422176 H80977 gb : yu89a11. s1Soaresfetalliverspleen 2. 7 439627 BE621702 Hs. 29076 hypothetical protein FU21841 2. 7 436532 AA721522 gb : nv54hl2. rl NCl_CGAP_Ew1 Homosapiens 2. 7 412833 AW960547 Hs. 298262 ribosome protein S19 2. 7 457245 A1745498 Hs. 204579 ESTs 2. 7 446861 Al696519 Hs. 14427 HomosapienscDNA : FLJ21800 fis, clone H 2. 7 453263 R91778 Hs. 99369 ESTs 2. 7 459385 BE380047 gb : 601159362F2 NIH_MGC_53 Homo sapiens c 2. 7 438764 AA824524 Hs. 336452 ESTs 2. 7 429285 A1971081 Hs. 20432 ESTs, Weakly similar to 138022 hypothefi 2. 7 424853 BE549737 Hs. 132967 Human EST clone 122887 mariner transposo 2. 7 430037 BE409649 Hs. 227789 mitogen-acGvated protein kinase-activat 2. 7 449892 N73608 Hs. 50309 ESTs 2. 7 454201 A8023191 Hs. 44131 KIAA0974 protein 2. 7 452279 AA286844 Hs. 61260 hypothetical protein FLJ 13164 2. 7 427954 J03060 Hs. 247551 metaxin 1 2. 7 400371 U80740 2. 7 452449 AW068658 Hs. 20943 ESTs 2. 7 431114 AA492400 Hs. 291015 ESTs 2. 7 417088 M54915 Hs. 81170 pim-1 oncogene 2. 7 447674 8E270640 Hs. 19192 cyclin-dependent kinase 2 2. 7 403680 2. 7 454679 AW813110 gb : CM4-ST0189-051099-021-fOSST0189Homo 2. 7 411968 A1207410 Hs. 69280 Homo sapiens, clone IMAGE : 3636299, mRNA, 2. 6 422240 R60594 Hs. 29002 KIAA1706 protein 2. 6 424368 AB037766 Hs. 146085 KIAA1345 protein 2. 6 405808 2. 6 419700 AF084935 Hs. 92357 galætohnae 1 2. 6 435972 W95088 Hs. 114198 ESTs 2. 6 453568 S70782 Hs. 557 adrenergic, alpha-1 D-, receptor 2. 6 443725 AW245680 Hs. 9701 growth arrest and DNA-damage-inducible, 2. 6 444156 AW500059 Hs. 86437 EsTsjHighlysimilarloAF2l9l4Olgatr 2. 6 428209 AA424197 Hs. 98947 ESTs, Weakly similar to S33496 trypsin [2. 6 437640 AA764893 Hs. 272155 EsTsXweaklysimilartol38o22hypothef 2. 6 453948 A1970797 Hs. 64859 ESTs 2. 6 415402 AA164687 Hs. 177576 mannosyl (alpha-1, 3-)-glycoprotein beta-2. 6,

425397 J04088 Hs. 156346 topoisomerase (DNA) 11 alpha (1 70kD) 2. 6 418228 AA962181 Hs. 111219 EsTstModeratelysimilartoAB1-HuMANA 2. 6 401324 2. 6 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypotheti 2. 6 443210 Api692649 Hs. 9451 hypothetical protein MGC13168 2. 6 457244 AA581385 Hs. 162473 ESTs, Weakly similar to 138022 hypotheb 2. 6 417144 AA382104 Hs. 81337 lectin, galactoside-binding, soluble, 9 2. 6 433933 Al754389 Hs. 133494 Homo sapiens clone TCCCIA00164 mRNA sequ 2. 6 437437 AA226869 Hs. 16520 hypothetical protein DKFZp762L0311 2. 6 434206 AW136973 Hs. 288516 ESTs, Weakly similar to S69890 mitogen i 2. 6 400992 2. 6 455530 AW984744 gb : RC1-HN0015-040400-0 1-d03 HN0015 Homo 2. 6 436139 AA765786 Hs. 120936 ESTs 2. 6 448330 AL036449 Hs. 207163 ESTs 2. 6 412942 AL120344 Hs. 75074 mitogen-activated protein kinase-activat 2. 6 432753 NM_014075 Hs. 336938 Homo sapiens PR00593 mRNA, complete cds 2. 6 433430 A1863735 Hs. 186755 ESTs 2. 6 436693 AW973223 Hs. 303197 B-cell CLLymphoma 7C 2. 6 429482 AF076974 Hs. 203952 transformation/transcription domain-asso 2. 6 432715 AA247152 Hs. 200483 ESTs, Weakly similar to KIAA1074 protein 2. 6 414217 AI309298 Hs. 279898 HomosapienscDNAFW2316Sfis, doneL 2. 6 434165 AA971328 Hs. 95361 myosinVIIA (Ushersyndrome1B (autosoma 2. 6 414835 AA156720 Hs. 185342 ESTs 2. 6 424489 T48851 Hs. 149250 D-sigle precursor, 2. 6 436496 AA281959 Hs. 5210 glia maturation factor, gamma 2. 6 403797 2. 6 434573 AW372340 Hs. 159717 ESTs 2. 6 418841 NM002332 Hs. 89137 low density lipoprotein-elated protein 2. 6 415785 R82419 Hs. 23603 ESTs, ModeratelysimilartoALU8_HUMANA 2. 6 450608 AA010365 Hs. 193229 ESTs 2. 6 425304 AA463844 Hs. 31339 fibroblast growth factor 11 2. 6 432268 BE311856 Hs. 274230 3'-phosphoadenosine 5'-phosphosulfate sy 2. 6 410507 AA355288 Hs. 40834 transitional epithelia response protein 2. 6 427343 Api880044 Hs. 176977 protein kinase C binding protein 2 2. 6 420917 AW135716 Hs. 117330 ESTs 2. 6 414399 L47345 Hs. 155202 transcription elongation factor B (Slil) 2. 6 446089 AI860021 Hs. 270651 ESTs, Moderately similar to A47582 B4el 2. 6 440829 AF136407 Hs. 7446 chromosome 6 open reading frame 5 2. 6 408475 AA315514 Hs. 47986 hypothetical protein MGC10940 2. 6 450946 AA374569 Hs. 127698 ESTs, Moderately similar to 2109260A B c 2. 6 421462 AF016495 Hs. 104624 aquaporin 9 2. 6 434846 AW295389 Hs. 119768 ESTs 2. 6 422887 A1751848 Hs. 49215 ESTs 2. 6 417435 NM 005181 Hs. 82129 carbonic anhydrasettt. muscte specific 2. 6 437389 AL359587 Hs. 271586 hypotheticalprotein DKFZp762M115 2. 5 408981 AW500797 Hs. 49427 Gem-interacting protein 2. 5 432180 Y18418 Hs. 272822 RuvB (E coli homolog)-like 1 2. 5 418079 R40058 Hs. 6911 ESTs 2. 5 437820 AA769062 Hs. 323836 ESTs, Weakly similar to alternatively sp 2. 5 439685 AW956781 Hs. 293937 ESTs. Weakly similar to FXD2_HUMAN FORKH 2. 5 425681 AB018297 Hs. 159183 KIAA0754 protein 2. 5 435177 A1018174 Hs. 42936 ESTs 2. 5 437323 Axa371145 Hs. 226627 leplinreceptor 2. 5 422114 AW194851 Hs. 111801 arsenate resistance protein ARS2 2. 5 448478 Al523218 Hs. 203456 ESTs 2. 5 426623 AA382826 Hs. 132793 ESTs 2. 5 448764 A1568607 Hs. 182112 ESTs 2. 5 458385 A1051489 Hs. 246214 ESTs 2. 5 403726 N28939 Hs. 13434 Homo sapiens clone 24418 mRNA sequence 2. 5 444888 Al651039 Hs. 148559 ESTs 2. 5 456179 H75490 Hs. 271930 ESTs 2. 5 424840 D79987 Hs. 153479 extra spindle poles, S. cerevisiae, homo 2. 5 406273 Nom000919 Hs. 83920 pepGdylglycine alpha-amidaGng monooxyg 2. 5 418054 Nom002318 Hs. 83354 lysyl oxidase-like 2 2. 5 445936 BE543594 Hs. 61478 hypothetical protein FU22329 2. 5 454967 AW848276 gb : IL3-CT0214-150200-074-E06 CT0214 Homo 2. 5 442303 AA989289 Hs. 129169 ESTs 2. 5 456583 AF179897 Hs. 104105 Meis (mouse) homolog 2 2. 5 434263 N34895 Hs. 44648 ESTs 2. 5 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducible. 2. 5 424528 AW073971 Hs. 238954 ESTs, Weakly similar to KIAA1204 protein 2. 5 406038 Y14443 Hs. 88219 zinc finger protein 200 2. 5 413495 Y12395 Hs. 315177 interferon-related developmental regulat 2. 5 423098 AA321980 Hs. 204682 ESTs 2. 5 410817 A1262789 Hs. 93659 protein disulfide isomerase related prot 2. 5 439841 AF038961 Hs. 6710 mannose-P-dolichol u6tization defect 1 2. 5 453828 AW970960 Hs. 293821 ESTs 2. 5 445034 AW293376 Hs. 143659 ESTs 2. 5 449620 BE407797 Hs. 23794 checkpoint with forkhead and ring finger 2. 5 406876 A1382286 Hs. 180842 ribosome protein L13 2. 5 412370 AW946614 gb : RC2-ET0021-280400-01 1-cO5 ET0021 Homo 2. 5 423642 AW452650 Hs. 157148 hypothetical protein MGC13204 2. 5 430357 AW976789 Hs. 165607 ESTs 2. 5

414853 U31116 Hs. 77501 sarcoglycan, beta (43kD dystrophin-assoc 2. 5 416097 BE387371 Hs. 118964 hypothetical protein FLJ20085 2. 5 428619 AK002140 Hs. 187378 hypotheticalproteinFLJ11278 2. 5 413976 BE295452 Hs. 75655 procollagen-proline, 2-oxogiutarate 44i 2. 5 445223 AW291553 Hs. 254983 ESTs 2. 5 423926 X03833 Hs. 1722 interleukin 1, alpha 2. 5 410165 BE560228 Hs. 71869 apoptosis-associated speck-like protein 2. 5 406474 2. 5 433908 AW298141 Hs. 157975 ESTs 2. 5 439755 AW748482 Hs. 77873 B7 homolog 3 2. 5 437528 N59646 Hs. 169745 crumbs (Drosophila) homolog 1 2. 5 420734 AW972872 Hs. 293736 ESTs 2. 5 415346 Z43108 gb : HSC13E071 normalized infant brain cDN 2. 5 419337 AW291112 Hs. 209978 ESTs 2. 5 444606 R09478 Hs. 18041 ESTs 2. 5 430061 AB037817 Hs. 230188 KIAA1396 protein 2. 5 413407 Api356293 Hs. 75339 inositol polyphosphate phosphatase-like 2. 5 411965 BE467339 Hs. 280115 ESTs 2. 5 409278 AA346683 Hs. 52763 anaphase-promofing complex subunit 7 2. 5 403142 2. 5 401714 2. 5 425081 X74794 Hs. 154443 minichromosome maintenance deficient (S. 2. 5 416505 H66470 Hs. 16004 ESTs 2. 5 431518 AA743462 Hs. 165337 ESTs 2. 5 448623 BE613468 Hs. 107515 ESTs, Weakly similar to T00329 hypotheb 2. 5 428301 AW628666 Hs. 98440 ESTs. Weakly similar to 138022 hypotheti 2. 5 404366 2. 5 449733 R74546 Hs. 29438 Homo sapiens cDNA FLJ 12094 fis, clone HE 2. 5 459583 A ! 907673 9b : lL-BT152-080399-004BT152Homosapien 2. 5 402856 AW939659 gb : RCO-DT0076-110100-031-cO9M0076Homo 2. 5 420751 J03019 Hs. 99913 adrenergic, beta-1-, receptor 2. 4 436805 AA731533 Hs. 270751 ESTs 2. 4 420285 AA258124 Hs. 293878 ESTs, ModeratelysimilartoZN91_HUMANZ 2. 4 453496 AA442103 Hs. 33084 solute carder family 2 (facilitated glu 2. 4 453653 AL040600 Hs. 188083 ESTs 2. 4 407909 AW103986 gb : xd63eO6. x1 NCl_CGAP_Ov23Homosapiens 2. 4 454630 BE142075 gb : CM3-HT0137-170999-012-f02 HT0137 Homo 2. 4 451026 AA013218 Hs. 157492 cer-d4 (mouse) homolog 2. 4 420779 L12398 Hs. 99922 dopamine receptor D4 2. 4 438322 AA804170 Hs. 221349 ESTs 2. 4 455908 BE156306 gb : QVO-HT0367-150200-114-h04 HT0367 Homo 2. 4 419625 U91616 Hs. 91640 nuclear factor of kappa light polypeptid 2. 4 440773 AA352702 Hs. 332541 Homo sapiens, Similar to RIKEN cDNA 2700 2. 4 450823 T81223 Hs. 22011 complement-clq tumor necrosis factor-rel 2. 4 447247 AW369351 Hs. 287955 Homo sapiens cDNA FLJ 13090 fis, clone NT 2. 4 429109 AL008637 Hs. 196352 neutrophil cytosolic factor 4 (40kD) 2. 4 451802 A1817711 Hs. 209374 ESTs 2. 4 419417 R92491 Hs. 39429 ESTs 2. 4 407094 AF000574 Hs. 22405 leukocyte immunoglobulin-like receptor, 2. 4 423567 BE252949 Hs. 69331 hypothetical protein FLJ13633 2. 4 427501 Api369280 Hs. 131743 ESTs 2. 4 451773 Z42044 Hs. 26996 KIAA1278 protein 2. 4 436845 AA732297 Hs. 113928 ESTs 2. 4 431584 AW296121 Hs. 266263 Homo sapiens cDNA FLJ14115 fis, clone MA 2. 4 440614 AA781530 Hs. 127236 hypothetical protein FLJ12879 2. 4 423721 AF176911 Hs. 132004 cardiotrophin-tikecytokine. neurotrophi 2. 4 452125 BE312642 Hs. 28077 GDP-mannose pyrophosphorylase B 2. 4 419508 AW997938 Hs. 90786 ATP-binding cassette, sub-family C (CFTR 2. 4 453446 BE299996 gb : 600944574F1 NIH_MGC_17 Homo sapiens c 2. 4 419792 AA250890 Hs. 190037 ESTs 2. 4 452786 R61362 Hs. 106642 ESTs, Weakly similar to T09052 hypotheti 2. 4 410447 AW816134 gb : MR3-ST0220-290100-016-e04ST0220Homo 2. 4 438662 AA223599 Hs. 6351 cleavage and polyadenylation specific fa 2. 4 402408 2. 4 443950 NM001425 Hs. 9999 epithelial membrane protein 3 2. 4 414625 AA335738 Hs. 76686 glutathione peroxidase 1 2. 4 403048 2. 4 432088 AA525454 gb : niB5c09. sl NCl_CGAP_Pr20Homosapiens 2. 4 431692 AL021331 Hs. 267749 unc93 (C. elegans) homolog A 2. 4 455023 AW850907 gb : IL3-CT0220-310100-065-H11 CT0220 Homo 2. 4 426249 F05422 Hs. 168352 nucleoporin-like protein 1 2. 4 446795 A1797713 Hs. 156471 ESTs 2. 4 414774 X02419 Hs. 77274 plasminogen acGvator, urokinase 2. 4 414252 AA346483 Hs. 126191 ESTs 2. 4 417918 AA209205 Hs. 163754 hypotheticalprotein FW12606 2. 4 427550 BE242818 Hs. 179606 nuclear RNA helicae, DECD vaiant of DE 2. 4 404020 2. 4 407846 AA426202 Hs. 40403 Cbp/p300-interacGng transactivator, wit 2. 4 417222 A1525424 Hs. 42053 hypothetical protein MGC2383 2. 4 443639 BE269042 Hs. 9661 proteasome (prosome, macropain) subunit, 2. 4 452706 AW449390 Hs. 257150 ESTs. Moderately similar to SURI-HUMAN S 2. 4 401676 2. 4 428882 AA436915 Hs. 131748 ESTs, ModeratelysimilartoALU7_HUMANA 2. 4

436277 R88520 Hs. 120917 ESTs 2. 4 426271 AF026547 Hs. 169047 chondroitin sulfate proteoglycan 3 (neur 2. 4 405353 2. 4 409193 AA131483 gb : zoO8eO5. rl Stratageneneuroepithelium 2. 4 431431 AL096711 Hs. 252953 HumanDNAsequencefromcloneRP3-403A15 2. 4 407889 R34556 Hs. 30800 ESTs, WeaklysimilartoS65657alpha-lC-2. 4 453335 AW857376 Hs. 169238 fucosyltransferase 3 (ga'ætoside 3 (4)-L 2. 4 450621 AW297288 Hs. 55918 hypothetical protein FLJ11354 2. 4 419652 AL157485 Hs. 91973 hypothetical protein 2. 4 421151 BE174431 Hs. 63386 ESTs 2. 4 437846 AA773866 Hs. 244569 esophagus cancer-related gene-2 2. 4 420681 AA847602 Hs. 106510 ESTs, ModeratelysimilartoALU2_HUMANA 2. 4 405288 2. 4 453527 R49570 Hs. 180236 ESTs 2. 4 429875 A1091815 gb : qa58b06. si Soares NhHMPu_S1 Homo sapi 2. 4 436360 A1962796 Hs. 136754 ESTs 2. 4 418592 X99226 Hs. 284153 Fanconi anemia, complementation group A 2. 4 419991 AJ000098 Hs. 94210 eyes absent (Drosophila) homolog 1 2. 4 449539 W80363 Hs. 58446 ESTs 2. 4 419870 AW403911 Hs. 266175 phosphoprotein associated with GEMs 2. 4 404584 2. 4 454276 AW294996 Hs. 255374 ESTs 2. 4 423746 AW361817 Hs. 132370 NADPH oxidase 1 2. 4 415558 AA885143 Hs. 125719 ESTs 2. 4 428141 D50402 Hs. 182611 solutecanierfamily 11 (proton-coupled 2. 4 406953 L36847 gb : Human (clone p17190) rearranged iduro 2. 4 444471 AB020684 Hs. 11217 KIAA0877 protein 2. 4 451031 A1360187 Hs. 4254 ESTs 2. 4 455302 AW997641 gb : RC6-BN0052-170200-011-DO6 BN0052 Homo 2. 4 449063 A1627352 Hs. 236547 Homo sapiens, clone IMAGE : 2905978, mRNA, 2. 4 401048 2. 4 434420 AA688278 Hs. 194864 hypothetcal protein FLJ22578 2. 4 425848 BE242709 Hs. 159637 valyl-tRNAsynthetase2 2. 4 449086 A1628357 Hs. 208037 ESTs 2. 4 415238 R37780 Hs. 21422 ESTs 2. 4 448337 AW206453 Hs. 3782 ESTs 2. 4 416991 N36389 Hs. 141296 KIAA0226 gene product 2. 3 412600 L28824 Hs. 74101 spteen tyrosine kinase 2. 3 418385 AW590613 Hs. 301040 Homo sapiens, clone IMAGE : 3357127, mRNA, 2. 3 440769 BE561793 Hs. 21446 KIAA1716 protein 2. 3 450437 X13956 Hs. 24998 hypotheUca'protein MGC10471 2. 3 412035 N78559 Hs. 293629 hypotheGcal protein MGC3121 2. 3 406739 A1566709 Hs. 182426 ribosomal protein S2 2. 3 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 2. 3 410286 A1739159 Hs. 61898 DKFZP586N2124 protein 2. 3 443740 R56434 Hs. 21062 ESTs 2. 3 405605 2. 3 416913 AW934714 gb : RC1-DT0001-031299-011-att DT0001 Homo 2. 3 426509 M31166 Hs. 2050 pentaxin-elatedgene, rapidlyinducedb 2. 3 445828 F05802 Hs. 81907 ESTs 2. 3 457195 AB011099 Hs. 196647 KIAA0527 protein 2. 3 420372 AW960049 Hs. 293660 Homo sapiens, clone IMAGE : 3535476, mRNA, 2. 3 423198 M81933 Hs. 1634 cell division cycle 25A 2. 3 457730 AW753613 gb : RC1-CT0268-060100-013-e01 CT0268 Homo 2. 3 412014 Al620650 Hs. 43761 ESTs, Weakly similar to A46010 X4inked 2. 3 447131 NM 004585 Hs. 17466 retinoic acid receptor responder (tazaro 2. 3 446288 AW189209 Hs. 149708 ESTs 2. 3 436954 AA740151 Hs. 130425 ESTs 2. 3 411658 AW855598 gb : CM1-CT0278-031199-032-e08 CT0278 Homo 2. 3 404240 2. 3 456094 H95091 gb : yw57a09. r1 Soares_placenta_8to9weeks_ 2. 3 416951 AA190926 Hs. 190785 ESTs, Moderately similar to S65657 alpha 2. 3 406737 A1356586 gb : qy15h09. x1 NCI_CGAP_Brn23Homosapien 2. 3 458453 A1097452 Hs. 135095 ESTs 2. 3 452330 Api879127 Hs. 191979 KIM1733 protein 2. 3 408523 AW833259 Hs. 314287 ESTs 2. 3 455470 AW947992 gb : PMO-MTO011-240300-001c09MT0011 Homo 2. 3 436323 R17697 Hs. 140963 ESTs, Weakly similar to 138022 hypotheti 2. 3 450000 A1952797 Hs. 10888 hypothetical protein FW21709 2. 3 416171 H23896 Hs. 125790 leucine-rich repeat-containing 2 2. 3 419134 T89863 Hs. 221771 ESTs 2. 3 445933 AV655733 Hs. 293860 spinster-like protein 2. 3 422089 AA523172 Hs. 103135 ESTs, Weakly similar to SFR4_HUMAN SPLIC 2. 3 449911 A1262106 Hs. 12653 ESTs 2. 3 417079 U65590 Hs. 81134 inteneukinlreceptorantagonist 2. 3 411742 AW247593 Hs. 71819 eukaryotictfansfation initiation factor 2. 3 435615 Y15065 Hs. 4975 potassium voltage-gated channel, KOT4ik 2. 3 423491 AA191765 Hs. 129673 eukaryotic translation initiation factor 2. 3 407182 AA312551 Hs. 230157 ESTs 2. 3 411448 AA178955 Hs. 271439 ESTs, Weakly similar to 138022 hypotheti 2. 3 438644 A1126162 Hs. 129037 ESTs 2. 3 432691 U29725 Hs. 3080 mitogen-activated protein kinase 7 2. 3 452198 A1097560 Hs. 61210 ESTs, Weakly similar to 138022 hypotheti 2. 3

411125 AA151647 Hs. 68877 cytochromeb-245, alphapolypepUde 2. 3 404054 2. 3 430458 AA479300 Hs. 225706 ESTs, Weakly similar to 138022 hypotheli 2. 3 440210 AW674562 Hs. 125296 ESTs 2. 3 446727 AB011095 Hs. 16032 KIAA0523 protein 2. 3 453775 NM 002916 Hs. 35120 replication factor C (activator 1) 4 (37 2. 3 438379 N23018 Hs. 171391 C-termina) binding protein 2 2. 3 449919 A1674685 Hs. 200141 ESTs 2. 3 415293 R49462 Hs. 106541 ESTs 2. 3 441126 NM000429 Hs. 323715 methionineadenosyitransferasei. atpha 2. 3 408203 AA053137 Hs. 42390 nasopharyngeal carcinoma susceptibility 2. 3 434941 AW073202 Hs. 334825 HomosapienscDNAFLJ14752fis, doneNT 2. 3 450748 A1733093 Hs. 130016 ESTs 2. 3 404185 2. 3 418327 U70370 Hs. 84136 paired-like homeodomain transcription fa 2. 3 451370 A1791929 Hs. 300782 ESTs 2. 3 400034 2. 3 407723 AW071161 Hs. 252873 ESTs 2. 3 431320 AW969474 Hs. 183070 ESTs 2. 3 429271 AF039850 Hs. 198515 dead ringer (Drosophilaplike 1 2. 3 453707 AW003879 Hs. 126522 Homo sapiens, clone MGC : 16722, mRNA, com 2. 3 419225 U70073 gb : HSU70073 Human Homo sapiens cDNA clon 23 444656 A1277924 Hs. 145199 ESTs 2. 3 405741 2. 3 400917 2. 3 432567 AA736777 Hs. 293770 ESTs 2. 3 437949 U78519 Hs. 41654 ESTs, Weakly similar to A46010 X-linked 2. 3 450514 AC005785 Hs. 25059 A kinase (PRKA) anchor protein 8 2. 3 418400 BE243026 Hs. 301989 KIAA0246 protein 2. 3 444019 BE173977 Hs. 10098 putative nucleolar RNA helicase 2. 3 406326 2. 3 412077 N51107 Hs. 47199 ESTs, Weakly similar to FU00004 protein 2. 3 427647 W19744 Hs. 180059 Homo sapiens cDNA FU20653 fis, clone KA 2. 3 414528 AA148950 Hs. 188836 ESTs 2. 3 414854 BE546797 Hs. 51483 ESTs, Weakly similar to hypothetical pro 2. 3 420352 BE258835 gb : 601117374F1 NlH_MGC_16Homosapiensc 2. 3 439467 AW292275 Hs. 158365 ESTs 2. 3 402627 2. 3 451711 AK000461 Hs. 26890 cat eye syndrome chromosome region, cand 2. 3 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 2. 3 423869 BE409301 Hs. 134012 C1q-elated factor 2. 3 405915 2. 3 431503 NM 012129 Hs. 258576 claudin 12 2. 3 423306 W88562 Hs. 108198 ESTs 2. 3 443232 AF161521 Hs. 9081 phenylalanyl-tRNA synthetase beta-subuni 2. 3 433064 D79991 Hs. 30002 SH3-containing protein SH3GLB2 ; KIAA1848 2. 3 434437 A1912566 Hs. 187813 ESTs 2. 3 436191 BE407866 Hs. 170253 hypothetical protein FLJ23282 2. 3 420006 H14429 Hs. 94300 serologically defined colon cancer antig 2. 3 447942 F12628 Hs. 334786 hypothetcat protein MGC16040 2. 3 403166 2. 3 422119 A1277829 Hs. 111862 KIAA0590 gene product 2. 3 403751 Z3 426451 Al908165 Hs. 169946 GATA-binding protein 3 2. 3 427413 BE547647 Hs. 177781 hypothetical protein MGC5618 2. 3 409091 AW970386 Hs. 269423 ESTs 2. 3 440491 R35252 Hs. 24944 ESTs, Weakly similar to 2109260A Bee cell 2. 3 427722 AK000123 Hs. 180479 hypotheticaiproteinFW20116 2. 3 405747 2. 3 438210 AA780519 Hs. 311601 EST 2. 3 404652 2. 3 423524 AF055989 Hs. 129738 potassium voltage-gated channel, Shaw-re 2. 2 426793 X89887 Hs. 172350 HIR (histone cell cycle regulation defec 2. 2 444424 A1654684 Hs. 196377 ESTs 2. 2 434031 BE384165 Hs. 23723 pseudouridylatesynthae1 2. 2 427650 AW501245 Hs. 252259 ribosome protein S3 2. 2 435220 D50030 Hs. 104 HGFactvator 22 438279 AA805166 Hs. 154762 HIV-1 rev binding protein 2 2. 2 424668 D83702 Hs. 151573 cryptochrome 1 (photolyase-like) 2. 2 429961 BE246829 Hs. 226770 DKFZP566C0424 protein 2. 2 442065 Au831229 Hs. 128417 hypothetical protein FLJ14009 2. 2 415198 AW009480 Hs. 943 natural killer cell transcript 4 2. 2 420536 AL117455 Hs. 275438 histone deacetylase 7A 2. 2 411263 BE297802 Hs. 69360 kinesin-like6 (mitoXccentromee-asoc 2. 2 443753 AW367578 Hs. 134749 ESTs 2. 2 423243 AA351938 Hs. 23964 sin3-associated polypepGde, 18kid 2. 2 446572 AV659151 Hs. 282961 ESTs 2. 2 412247 AF022375 Hs. 73793 vascular endothelial growth factor 2. 2 421040 AA715026 Hs. 135280 ESTs 2. 2 426212 S71824 Hs. 167988 neural cell adhesion molecule 1 2. 2 455584 BE007420 gb : PM3-BN0142-200300-001-c04BN0142Homo 2. 2 406851 AA609784 Hs. 180255 major histocompatibility complex, class 2. 2 444153 AK001610 Hs. 10414 hypothetical protein FLJ10748 2. 2

419575 U43431 Hs. 91175 topoisomerase (DNA) III alpha 2. 2 418672 L44284 Hs. 159743 ESTs 2. 2 456261 AA210718 Hs. 104157 ESTs, Weakly similar to KIAA0694 protein 2. 2 415737 AA167626 Hs. 118743 ESTs 2. 2 447554 Api391598 Hs. 36119 ESTs, WeaklysimilartoALU1_HUMANALUS 2. 2 405159 2. 2 442177 AW661820 Hs. 211413 ESTs Z2 446139 H77395 Hs. 39749 ESTs 2. 2 458339 AW976853 Hs. 172843 ESTs 2. 2 401876 2. 2 439566 AF086387 gb : Homo sapiens full length insert cDNA 2. 2 425079 H09963 Hs. 2257 vitronectin (serum spreading factor, som Z2 441837 AA361743 Hs. 179881 core-binding factor, betasubunit 2. 2 430644 AB015419 Hs. 247710 peproprolxún-releasing peptide 2. 2 431474 AL133990 Hs. 190642 ESTs 2. 2 407739 NM_002285 Hs. 38070 lymphoid nuclear protein related to AF4 2. 2 424244 AV647184 Hs. 143601 hypothetical protein hCLA-iso 2. 2 438057 AW294544 Hs. 125785 ESTs, Weakly similar to CORB MOUSE CORNI 2. 2 412715 Nom000947 Hs. 74519 primae, polypepGde 2A (58kD) 2. 2 422365 AF035537 Hs. 115521 REV3 (yeast homolog)-like, catalytic sub 2. 2 404170 Z2 406902 M32074 gb : Human retinoic acid receptor gamma 2 2. 2 437902 AA770599 Hs. 144055 ESTs 2. 2 401012 2. 2 446502 A1302654 Hs. 208024 ESTs 2. 2 442554 AW467376 Hs. 129640 ESTs 2. 2 443021 AA368546 Hs. 8904 lg superfamily protein 2. 2 421141 AW117261 Hs. 125914 ESTs 2. 2 443070 BE388662 Hs. 8984 Homo sapiens chromosome 14 BAC 98L12 2. 2 446566 H95741 Hs. 17914 membrane-spanning 4-domains, subfamily A 2. 2 427695 R88483 Hs. 172862 ESTs 2. 2 426503 AA380153 gb : EST93093 Skin tumor I Homo sapiens cD 2. 2 431468 AW248431 Hs. 256526 nuclear prelamin A recognition factor 2. 2 416185 AW975861 Hs. 47367 KIAA1785 protein 2. 2 437319 BE410958 Hs. 56406 Homo sapiens cDNA FU 13549 fis, clone PL 2. 2 402064 2. 2 413335 A1613318 Hs. 48442 ESTs 2. 2 408212 AA297567 Hs. 43728 hypothetical protein 2. 2 406169 2. 2 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 2. 2 407335 AA631047 Hs. 158761 Homo sapiens cDNA FW13054 fis, clone NT 2. 2 409715 W42591 Hs. 23892 ESTs 2. 2 431921 N46466 Hs. 58879 ESTs 2. 2 443823 BE089782 Hs. 9877 hypothetical protein 2. 2 432458 A1968598 Hs. 78768 malignant cell expression-enhanced gene/2. 2 419726 U50330 Hs. 1274 bone morphogenetic protein 1 2. 2 423178 A1033140 Hs. 124983 Homo sapiens mRNA ; cDNADKFZp564C142 (fr 2. 2 451089 AA903705 Hs. 4190 Homo sapiens cDNA : FLJ23269 fis, clone C 2. 2 415216 A1825905 Hs. 193211 Homo sapiens CDNA FLJ 11421 fis, clone HE 2. 2 442242 AV647908 Hs. 90424 Homo sapiens cDNA : FLJ23285 fis, clone H 2. 2 441830 AA383104 Hs. 42954 hypothetical protein DKFZp564D0372 2. 2 406660 X65371 Hs. 172550 potypyrimidine tract binding protein (he 2. 2 443378 AW392550 Hs. 9280 proteasome (prosome, macropain) subunit. 2. 2 432558 R97268 Hs. 177269 ESTs 2. 2 408146 R45621 Hs. 81057 hypothetical protein MGC2718 2. 2 419865 NM007020 Hs. 93502 U1-snRNP binding protein homolog (70kD) 2. 2 439444 A1277652 Hs. 54578 ESTs, Weakly similar to 138022 hypotheti 2. 2 438407 Al457122 Hs. 129673 eukaryotic translation initiation factor 2. 2 450184 W31096 Hs. 237617 Homo sapiens, clone IMAGE : 3447394, mRNA, 2. 2 409130 BE076601 Hs. 75658 phosphorylase, glycogen ; brain 2. 2 428844 AW972635 Hs. 301904 hypothetical protein FLJ12671 2. 2 429489 AF008203 Hs. 204039 aistaless-like homeobox 3 2. 2 433042 AW193534 Hs. 281895 HomosapienscDNAFW11660hs, cloneHE 2. 2 440658 H29142 Hs. 143032 ESTs, Weakly similar to neuronal thread 2. 2 408204 AA454501 Hs. 43666 protein tyrosine phosphatase type IVA, m 2. 2 427498 NM_003926 Hs. 178728 methyl-CpG binding domain protein 3 2. 2 408006 H57654 Hs. 303345 ESTs, Weakly similar to 138022 hypotheti 2. 2 445703 AV654845 Hs. 27 glycine dehydrogenase (decarboxylating ; 2. 2 431446 AW294929 Hs. 255369 Homo sapiens CDNA FU 10265 fis, clone HE 2. 2 456660 AA909249 Hs. 112282 solute carrier family 30 (zinc transport 2. 2 433099 NM002504 Hs. 3187 nuclear ranscription factor, X-box bind 2. 2 415857 AA866115 Hs. 127797 HomosapienscDNAFW11381fis, cloneHE 2. 2 415245 N59650 Hs. 27252 ESTs 2. 2 443657 R14973 gb : yf42 (10. sl Soaresfetal liverspleen 2. 2 402521 AW501216 Hs. 108945 KIAA0515 protein 2. 2 414819 BE177320 Hs. 156148 hypothetical protein FU13231 2. 2 446530 AV658909 Hs. 282642 ESTs Z2 415797 A1291896 Hs. 72800 ESTs 2. 2 414812 X72755 Hs. 77367 monokine induced by gamma interferon 2. 2 453028 AB006532 Hs. 31442 RecQprotein-like4 2. 2 412133 U83460 Hs. 73614 solutecanierfamily31 (coppertranspo 2. 2 407881 AW072003 Hs. 40968 heparan sulfate (gluoosamine) 3-0-sulfot 2. 2 437033 AW248364 Hs. 5409 RNA polymerase I subunit 2. 2

422732 AA577455 Hs. 24937 transfommer-2alpha (htra-2alpha) 2. 2 416388 A1417358 Hs. 73677 ESTs 2. 2 452849 AF044924 Hs. 30792 hook2 protein 2. 2 446615 BE513202 Hs. 15589 PPAR binding protein 2. 2 428361 NM_015905 Hs. 183858 transcriptional intermediary factor 1 2. 2 446279 AA490770 Hs. 182382 ESTs 2. 2 422938 NM_001809 Hs. 1594 centromere protein A (17kD) 2. 2 403969 2. 2 410423 AW402432 Hs. 63489 protein tyrosine phosphatase, non-recept 2. 2 429736 AF125304 Hs. 212680 tumor necrosis factor recepto superfami 2. 2 447091 AW089648 Hs. 157779 ESTs, Weakly similar to CA17 HUMAN COLLA 2. 2 422017 NM003877 Hs. 110776 STAT induced STAT inhibitor-2 2. 2 426728 NM007118 Hs. 171957 triple functional domain (PTPRF interact 2. 2 438726 AB033103 Hs. 6385 Kit1277 protein 2. 2 453315 BE544203 Hs. 24831 ESTs 2. 2 423244 AL039379 Hs. 209602 ESTs, Weakly similar to ubiquitous TPR m 2. 2 433610 AA806822 Hs. 112547 ESTs 2. 2 429451 BE409861 Hs. 202833 heme oxygenase (decycling) 1 2. 2 417980 R32235 gb : yh67fQ8. r1 Scares placenta Nb2HP Homo 2. 2 406347 2. 2 414406 BE297904 gb : 601177814F1 NIH_MGC_17 Homo sapiens c 2. 2 401827 2. 2 446913 AA430650 Hs. 16529 transmembrane 4 superfamily member (tetr 2. 2 452294 Ai871925 Hs. 117895 ESTs, Moderately similar to A47582 B-cel 2. 2 404084 2. 2 456786 AK002084 Hs. 132851 hypothetical protein FLJ11222 2. 2 435031 A1632091 Hs. 116877 ESTs 2. 2 442609 AL020996 Hs. 8518 selenoprotein N 2. 1 439732 AW629604 Hs. 167641 hypothetical protein from EUROIMAGE 1703 2. 1 421506 BE302796 Hs. 105097 thymidine kinase 1, soluble 2. 1 439253 AF086064 Hs. 332252 ESTs 2. 1 409669 AW177551 Hs. 220255 hypothetical protein MGC13098 2. 1 429574 BE268321 Hs. 208912 hypothetical protein MGC861 2. 1 437470 AL390147 Hs. 134742 hypothetical protein DKFZp547D065 2. 1 408945 AW015089 Hs. 4964 DKFZP586J1624protein 2. 1 447687 A1627947 Hs. 150186 hypotheticalprotein DKFZpS66K1946 2. 1 459584 A1910884 Hs. 207898 ESTs 2. 1 439130 AA306090 Hs. 124707 ESTs 2. 1 428180 Api129767 Hs. 182874 guanine nucleotide binding protein (G pr 2. 1 442028 Al239437 Hs. 48945 ESTs 2. 1 430968 AW972830 gb : EST384925 MAGE resequences, MAGL Homo 2. 1 443609 AV650231 Hs. 282941 ESTs, Highly similar to A Chain A, Human 2. 1 417164 AA338283 Hs. 81361 heterogeneous nuclear ribonucleoprotein 2. 1 444534 AW271626 Hs. 42294 ESTs 2. 1 438391 A1262248 Hs. 25027 ESTs 2. 1 442003 AW297497 Hs. 201891 ESTs 2. 1 456278 BE300369 Hs. 289038 hypothetical protein MGC4126 2. 1 416976 BE243985 Hs. 80680 major vault protein 2. 1 417810 D28419 Hs. 82609 hydroxymethylbilane synthase 2. 1 445242 BE156478 Hs. 21108 ESTs. Weakly similar to ALU1 _H UMAN ALU S 2. 1 452712 AW838616 gb : RC5-LT0054-140200-013-D01LT0054Homo 2. 1 434926 BE543269 Hs. 50252 mitochondrial ribosomal protein L32 2. 1 421564 AB007864 Hs. 105850 KIAA0404 protein 2. 1 424927 AW973666 Hs. 153850 hypothetical protein C321D2. 4 2. 1 432742 AA564453 Hs. 162339 ESTs 2. 1 435958 H98180 Hs. 117975 ESTs 2. 1 421531 AA713505 Hs. 291769 ESTs 2. 1 410431 BE261320 Hs. 158196 transcriptional adaptor 3 (ADA3, yeast h 2. 1 420503 A1570943 Hs. 337546 ESTs 2. 1 448127 Api478416 Hs. 282883 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 1 452897 BE066058 Hs. 269233 ESTs, Moderately similar to 178885 serin 2. 1 447112 H17800 Hs. 7154 ESTs 2. 1 406577 2. 1 437162 AW005505 Hs. 5464 thyroid hormone receptor coactivatingpf 2. 1 451460 A1797550 Hs. 209652 ESTs 2. 1 447402 H54520 Hs. 18490 hypotheGcal protein FLJ20452 2. 1 435828 AA700705 Hs. 13852 ESTs 2. 1 436396 A1683487 Hs. 152213 wingless-type MMTV integration site fami 2. 1 420582 BE047878 Hs. 99093 Homosapienschromosomel9, cosmidR2837 2. 1 452020 AA722012 Hs. 255757 ESTs, WeaklysimilartoAT2A HUMANPOTEN 2. 1 415586 Z45481 gb : HSC2QE041 normalized infant brain cDN 2. 1 452620 AA436504 Hs. 119286 ESTs 2. 1 457066 BE244613 Hs. 158272 ESTs, Weakly similar to CA13 MOUSE COLLA 2. 1 435472 AW972330 Hs. 283022 triggedng receptor expressed on myeloid 2. 1 431741 AA514783 Hs. 191701 ESTs 2. 1 446840 AW294828 Hs. 209203 ESTs 2. 1 440818 Al147060 Hs. 146726 ESTs 2. 1 410174 AA306007 Hs. 59461 DKFZP434C245 protein 2. 1 400822 2. 1 412760 AW379030 Hs. 41324 ESTs 2. 1 410653 BE383768 Hs. 65238 95 kDa refinoblastoma protein binding pr 2. 1 426925 NM 001196 Hs. 315689 Homo sapiens cDNA : FLJ22373 fis, clone H 2. 1 424242 AA337476 Hs. 293984 hypothetical protein MGC13102 2. 1

452560 BE077084 Hs. 336432 ESTs 2. 1 456437 A1924228 Hs. 115185 ESTs, Moderately similar to PC4259 ferri 2. 1 458922 BE501831 Hs. 282053 ESTs 2. 1 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 2. 1 419488 AA316241 Hs. 90691 nucleophosmin/nucleoplasmin 3 2. 1 411829 AW865749 gb : QV3-SN0021-100500-15-c03 SN0021 Homo 2. 1 457192 AL135682 Hs. 22452 Homo sapiens mRNA for KIAA1737 protein, 2. 1 422128 AW881145 gb : QVO-OT0033-010400-182-aO70T0033Homo 2. 1 452571 W31518 Hs. 34665 ESTs 2. 1 423699 H41850 Hs. t31846 PCAF associated factor 65 alpha 2. 1 406610 2. 1 453638 AW814996 gb : MR1-ST0206-170400-024-h09 ST0206 Homo 2. 1 418856 AA362858 gb : EST72900 Ovary II Homo sapiens cDNA 5 2. 1 437623 D63880 Hs. 5719 chnomosomecondensaton-relatedSMC-asso 2. 1 410908 AA121686 Hs. 10592 ESTs 2. 1 420221 N25991 Hs. 43725 ESTs 2. 1 424739 AA346108 Hs. 221610 ESTs Z1 425398 AL049689 Hs. 156369 hypothetical protein similar to tenascin 2. 1 424901 Z11933 Hs. 182505 POU domain, class 3, transcription facto 2. 1 411096 U80034 Hs. 68583 mitochonddal intermediate pepbdase 2. 1 415635 F13168 gb : HSC3JF101 normalized infant brain cDN 2. 1 418181 U37012 Hs. 83727 cleavage and potyadenylaGoo specific fa 2. 1 407103 AA424881 Hs. 256301 hypothetical protein MGC13170 2. 1 454389 AW752571 gb : lL3-CT0213-170100-055-F02CT0213Homo 2. 1 400021 2. 1 439228 N51700 gb : yy72dO1. sl Soares_multiple_scierosis_ Z1 456505 AA504595 Hs. 111418 ESTs 2. 1 405258 2. 1 444645 A1184564 Hs. 101654 ESTs 2. 1 430246 Ai269069 Hs. 109268 hypothetical protein Fla12552 2. 1 458687 AW024815 Hs. 170088 GLUT4 enhancer factor 2. 1 403857 2. 1 400258 2. 1 422221 AA306649 Hs. 169370 FYN oncogene related to SRC, FGR, YES 2. 1 441054 AA913591 Hs. 126480 ESTs 2. 1 452700 AI859390 Hs. 288940 five-span transmembrane protein M83 2. 1 454606 AW809752 gb : MR4-ST0124-181299-020-bO6 ST0124 Homo 2. 1 448954 AB014564 Hs. 22616 KIAA0664 protein 2. 1 443148 A1034357 Hs. 211194 ESTs. Weakly similar to ALUB HUMAN ALU S 2. 1 453486 AL039201 Hs. 173554 ubiquinol-cytochrome c reductase core pr 2. 1 437695 AA769202 Hs. 192142 ESTs 2. 1 425449 X52056 Hs. 157441 spleen focus forming virus (SFFV) provir 2. 1 447270 AC002551 Hs. 331 general transcription factor IIIC, polyp 2. 1 435677 AA694142 Hs. 293726 ESTs, Weakly similar to TSGA RAT TESTIS 2. 1 436382 AW977063 Hs. 250181 ESTs 2. 1 435837 A1689210 Hs. 187276 HomosapienscDNAFW11431fis, cloneHE 2. 1 458287 AA987556 Hs. 12867 ESTs 2. 1 423794 BE551781 Hs. 231895 ESTs 2. 1 408049 AW076098 Hs. 74316 desmoplakin (OPI, DPII) 2. 1 402721 2. 1 451999 AW176401 Hs. 27424 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2. 1 417541 Api992191 Hs. 180040 hypothetical protein FU22439 2. 1 414857 AW402389 Hs. 920 modulator recognition factor I 2. 1 435760 AF231922 Hs. 213004 chromosome 21 open reading frame 62 2. 1 428086 AL110193 Hs. 224137 hypothetical protein 2. 1 447853 A1434204 Hs. 164285 ESTs, WeaklysimilartoAFG1yEAsTAFGl 2. 1 419034 NM_002110 Hs. 89555 hemopoiefic cell kinase 2. 1 431019 NM 005249 Hs. 2714 forkhead box GIB 2. 1 421064 A1245432 Hs. 101382 tumor necrosis factor, alpha-induced pro 2. 1 416435 A1431301 Hs. 179703 KIAA0129 gene product 2. 1 437014 AA808757 Hs. 222531 ESTs, Weakly similar to S59501 interfero 2. 1 459369 T83080 gb : yd40eO3. r1 Scares fetal liver spleen 2. 1 402239 2. 1 412280 AW205116 Hs. 272814 hypothetical protein DKFZp434E1723 2. 1 426012 AA367507 Hs. 75874 pregnancy-associated plasma protein A 2. 1 438885 A1886558 Hs. 184987 ESTs 2. 1 426076 AW962714 gb : EST374787 MAGE resequences, MAGG Homo 2. 1 404561 2. 1 442932 AA457211 Hs. 8858 bromodomain adjacent to zinc finger doma 2. 1 408175 W29089 Hs. 19066 hypothetical protein DKFZp66702416 2. 1 423867 AA331886 gb : EST35757 Embryo, 8 week I Homo sapien 2. 1 458604 W37944 Hs. 4007 Sarcolemmal-associated protein 2. 1 409650 T08490 Hs. 288969 HSCARG protein 2. 1 401729 2. 1 433675 AW977653 Hs. 75319 ribonucleotide reductase M2 polypeptide 2. 1 456741 W37608 Hs. 184492 ESTs 2. 1 417037 BE083936 Hs. 80976 antigen identified by monoclonal antibod 2. 1 415079 R43179 Hs. 22895 hypothetical protein FLJ23548 2. 1 439262 AA832333 Hs. 333045 ESTs 2. 1 403108 2. 1 436718 AW015227 Hs. 289053 hypothetical protein FLJ14733 2. 1 440696 A1762757 Hs. 187660 putative RabS GDP/GTP exchange factor ho 2. 1 409745 AA077391 gb : 7B14E12 Chromosome 7 Fetal Brain cDNA 2. 1

453485 BE620712 Hs. 33026 hypothetical protein PP2447 2. 1 418177 N44967 Hs. 5663 ESTs 2. 1 457292 A1921270 Hs. 334882 hypothetical protein FW14251 2. 1 454434 AA083558 Hs. 261286 ESTs 2. 1 406085 2. 1 424441 X14850 Hs. 147097 H2A histone family, member X 2. 1 422726 U11690 Hs. 1572 faciogenitaldysplasia (Aarskog-Scottsy 2. 1 424576 BE154142 Hs. 96833 ESTs 2. 1 423660 AL045228 Hs. 130831 Homo sapiens mRNA ; cDNADKFZp434L137 (fr 2. 1 403509 AF231919 Hs. 18759 KIAA0539 gene product 2. 1 441940 AW298115 Hs. 128152 ESTs 2. 1 439190 AW978693 Hs. 293811 ESTs 2. 1 417791 AW965339 Hs. 111471 ESTs 2. 1 423701 AA329856 Hs. 143022 ESTs 2. 1 427239 BE270447 Hs. 174070 ubiquitin carrier protein 2. 1 459642 BE243103 gb : TCAAP2E0949 Pediatric acute myelogeno 2. 1 450385 Api631024 Hs. 24948 synuclein, alpha interacting protein (sy 2. 1 425159 NM_004341 Hs. 154868 carbamoyl-phosphatesynthetase2, aspat 2. 1 425591 AW294734 Hs. 279727 Homo sapiens cDNA FW 14035 fis, clone HE 2. 1 445101 T75202 Hs. 12314 Homo sapiens mRNA ; cDNA DKFZpS86C1019 (f 2. 1 412811 H06382 Hs. 21400 ESTs 2. 1 426369 AF134157 Hs. 169487 Kreisler (mouse) maf-related leucine zip 2. 1 435924 AW029203 Hs. 191952 ESTs 2. 1 418388 R72332 Hs. 29258 Homo sapiens cDNA FLJ11364 fis, clone HE 2. 1 452235 AL039743 Hs. 28514 testes development-related NYD-SP21 2. 1 452313 Y00486 Hs. 28914 adenine phosphoribosyltransferase 2. 1 450704 H85157 Hs. 40696 ESTs 2. 1 427539 AA405205 Hs. 97960 ESTs, Weakly similar to T51146 ring-box 2. 1 402028 2. 1 405362 2. 1 414718 H95348 Hs. 107987 ESTs 2. 1 433424 R68252 Hs. 163566 ESTs 2. 1 444875 A1200759 Hs. 44737 ESTs 2. 0 449523 NM 000579 Hs. 54443 chemokine (GC moti receptor 5 2. 0 456072 H54381 gb : yq69a03. s1Soaresfetalliverspleen 2. 0 436331 A1239495 Hs. 120189 ESTs 2. 0 448418 Z43704 Hs. 21192 Homosapiensclone25155mRNAsequence 2. 0 447250 Api878909 Hs. 17883 protein phosphatze tG (fommerRy 2C), ma 2. 0 448192 R43915 Hs. 4958 ESTs 2. 0 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 2. 0 408605 AF025374 Hs. 46465 T-cell, immune regulator 1 2. 0 410790 AW803357 gb : IL2-UM0079-090300-050-A08 UM0079 Homo 2. 0 436872 X15624 gb : Human H1 RNA 2. 0 432238 AL133057 Hs. 274135 Homo sapiens mRNA ; cDNA DKFZp434K1815 (f 2. 0 446307 T50083 Hs. 9094 ESTs 2. 0 436588 AA759233 Hs. 126506 ESTs 2. 0 452487 AW207659 Hs. 6630 Homo sapiens cDNA FU13329 fis, clone OV 2. 0 430420 AW140027 Hs. 26373 Homo sapiens cDNA : FLJ23449 fis, clone H 2. 0 432036 AF224266 Hs. 272373 interleukin 20 2. 0 414460 L00727 Hs. 898 dystrophia myotonica-protein kinase 2. 0 433507 A1817336 Hs. 191791 ESTs 2. 0 427964 AA418082 Hs. 98286 ESTs, Weakly similar to T20655 hypotheti 2. 0 443108 W86975 Hs. 203707 ESTs 2. 0 434504 A1887341 Hs. 121590 hypothetical protein FU12827 2. 0 454310 AW818390 Hs. 175613 homoloXq of Xenopus Oapin 2. 0 443566 A1290284 Hs. 159872 ESTs 2. 0 449722 BE280074 Hs. 23960 cyclin B1 2. 0 452682 AA456193 Hs. 9071 progesterone membrane binding protein 2. 0 412362 AW945484 Hs. 184252 ESTs, WeaklysimilarloALU8_HUMANALUS 2. 0 429341 X73874 Hs. 2393 phosphorylase kinase, alpha 1 (muscle) 2. 0 435863 AF255346 Hs. 62919 Jun dimerizaton protein p21SNFT 2. 0 400774 R58624 Hs. 2186 eukaryotictranstationetongation factor 2. 0 453944 AW975369 Hs. 292570 Homo sapiens, clone IMAGE : 3502107, mRNA, 2. 0 419227 BE537383 Hs. 89739 cholinergic receptor, nicotinic, beta po 2. 0 448529 T26460 Hs. 22550 ESTs 2. 0 443206 AB011420 Hs. 9075 serine/threonine kinase 17a (apoptosis-i 2. 0 439360 AA448488 Hs. 336629 ribosomal protein L44 2. 0 436660 Api658870 Hs. 184513 ESTs 2. 0 449030 A1365582 Hs. 57100 Homo sapiens mRNA for FU00016 protein, 2. 0 411048 AK001742 Hs. 67991 hypothetical protein DKFZp434G0522 2. 0 406624 AF052762 gb : Homo sapiens clone csne98-1immunog) o 2. 0 450666 T99968 Hs. 18799 ESTs, Weakly similar to 138022 hypotheti 2. 0 446143 BE245342 Hs. 306079 sec61 homolog 2. 0 437698 R61837 Hs. 7990 ESTs, Moderately similar to 184505 calci 2. 0 426607 AA382330 Hs. 124223 ESTs 2. 0 449246 AW411209 Hs. 23363 hypothetical protein FUI0983 2. 0 422564 A1148006 Hs. 222120 ESTs 2. 0 432682 A1376400 Hs. 159588 ESTs 2. 0 422140 BE295918 Hs. 112193 mutS (E. coli) homolog 5 2. 0 408215 BE614290 Hs. 43812 syntaxin 10 2. 0 417129 AI381800 Hs. 300684 calcitonin gene-related peptide-receptor 2. 0 442772 AW503680 Hs. 5957 Homo sapiens clone 24416 mRNA sequence 2. 0 434928 AW015595 Hs. 4267 Homo sapiens clones 24714 and 24715 mRNA 2. 0

411380 AW841619 gb : RC1-CN0017-120200-012-b09 CN0017 Homo 2. 0 430603 AA148164 Hs. 247280 HBV associated factor 2. 0 425905 AB032959 Hs. 318584 novel C3HC4 type Zinc finger (ring finge 2. 0 401125 2. 0 412939 AW411491 Hs. 2186 eukaryotic translation elongation factor 2. 0 448740 BE250632 Hs. 8026 sestrin 2 2. 0 454390 AB020713 Hs. 56966 KIAA0906 protein 2. 0 415012 NM004383 Hs. 77793 c-src tyrosine kinase 2. 0 410407 X66839 Hs. 63287 carbonic anhydrase IX 2. 0 403478 2. 0 456485 Api393037 Hs. 97871 Homo sapiens, done IMAGE : 3845253, mRNA, 2. 0 430294 A1538226 Hs. 32976 guanine nucleotide binding protein 4 2. 0 411669 BE612676 Hs. 303116 stromalcell-denvedfætor2-like1 2. 0 451944 AW445218 Hs. 210876 ESTs 2. 0 436395 AJ227900 gb : Homo sapiens partial mRNA ; ID EE2-16B 2. 0 456457 AA252905 Hs. 194477 E3ubiquiGnligaeSMURF2 2. 0 449123 D50920 Hs. 23106 KIAA0130 gene product 20 409214 AW405967 Hs. 333388 Homo sapiens, done IMAGE : 3957135, mRNA, 2. 0 437619 AW351491 Hs. 334853 hypothetical protein FU23544 2. 0 453348 BE272318 Hs. 8595 hypothetical protein FU12438 2. 0 424382 AA351898 Hs. 23539 ESTs 2. 0 447079 AA280057 Hs. 105280 ESTs, Weakly similar to dJ963K23. 2 [H. sa 2. 0 449501 Al652924 Hs. 231942 ESTs 2. 0 422893 X98411 Hs. 121555 myosinlF 2. 0 412125 Y17114 Hs. 73393 eyes absent (Drosophila) homolog 4 2. 0 434845 BE267057 Hs. 325321 hypotheúcal protein R32184_1 2. 0 410422 AL042014 Hs. 334698 Homo sapiens, clone MGC : 15203, mRNA, com 2. 0 430255 AK000703 Hs. 323822 Homo sapiens mRNA for KIAA1551 protein, 2. 0 451656 BE327088 Hs. 212752 ESTs 2. 0 442068 BE312873 Hs. 314932 ESTs 2. 0 446846 AW197626 Hs. 271901 ESTs, Moderately similar to S08686 finge 2. 0 442690 Al014727 Hs. 160047 ESTs, Weakly similar to B28096 line-1 pr 2. 0 454277 AW295069 Hs. 31743 ESTs, Weakly similar to Z157-HUMAN ZINC 2. 0 426910 AA470023 Hs. 190089 ESTs, Moderately similar to ALU1 HUMAN A 2. 0 402798 2. 0 404554 2. 0 TABLE 25B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 407909 1025254 1 AW103986 BE156395 BE156391 BE156190 BE156184 BE156388 BE156394 408432 1058667 1 AW195262R27868AW811262 409193 110747 1 AA131483 AA065156 AA076448 409745 115237-1 AA077391 A1347618 A1361453 A1088754 AW207491 AW960912 AA921874 AA286833 AA150722 BE152353 AW1 88822 BE152450 410447 1203929 1 AW816134 BE063456 AW748795 BE150839 410790 1221131 1 AW803357 AW803423 AW812233 R06814 411256 1236790_1 AW834039 AW834040 AW834047 AW845410 BE003128 AW852479 411380 1242343_1 AW841619AW851958AW851851 AW851985 411632 1252361_1 AW654829 AW854805 AW854841 AW854825 AW854822AW854830 AW854835 AW854826 411658 1252987 1 AW855598 AW855608 BE148763 BE148764 AW855645 AW855615 AW855596 AW855610 AW855601 AW855605 411829 1260309_1 AW865749 BE179419 BE179492 412225 12841081 AW902042 N77591 412370 1291952 1 AW946614 AW946622 AW946663 AW946667 AW946615 AW946619 412391 1292625-1 AW947710 AW947698 AW947697 AW947713 413257 13559631 BE075035 BE074999 BE075006 BE075005 BE075032 BE075008 BE075037 413604 1379715 1 R51767BE152515Z44834H23397 414406 1443333_1 BE297904 BE294312 414550 1460990-1 BE379808 415346 1534581 1 Z43108 F06295 R13085 415406 1536026 1 T26510 F07926 R53367 415586 1540116-1 Z45481 Fl 2393 T74437 415635 1540853 1 F13168 R21289 T77628 416871 1626761_1 H98716 N90792 N24283 416913 163001 1 AW934714 BE161007 BE162500 AW749902 AW749864 BEt62498 BE161005 AA190449 AW513465 BE161006 BE162499 417980 1712954 1 R32235 R32247 R32219 418333 173_2 W92113 AA702794 BE044316 W91984 AA679375 T94184 AA679335 BE503126 AW502118 BE467367 AA584550 AW139964 R93353AW088477 A1887846 AW502624 W81697 W81696 AA447817 AA447667 F13631 AW268271 AA055366 AW629027 AA677404 AA831618 Al124782 M889402 AA765804 AA765530 AA055698 AA594019 AI267368 AA456946 R93354 AF264624 AW668618 AA601493 418856 179649 AA362858AW863761AA229428 419217 182954 AA504571AA235243AA411737AW969068AA406543 419225 1830274-1 U70073 419311 183793 1 AA689591 AW974261 AA236240 A1077451 AA631399 AW974262 420352 192979-1 BE258835 AW968316 AA258918 AW843305 R14744 580388 BE071923 R36280 422128 211994_1 AW981 145 AA490718 M85637 AA304575 T06067 AA331991 422156 212379_1 N34524 AA305071 AW954803 AA502335 At433430 At203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512 Api334966 W32951 H62656 H53902 R88904 AW835732 422176 212714 1 H80977 BEt47695 AA305496 AW962366 AA436754 423756 231725J AA828125AA834883AA330555 423867 232732 1 AA331886 AW962659 AW962655 T89841 425189 247825_1 H16622 R17322 AA351959

425517 252729 1 AF121179 BE162736 AA358827 426076 260504 1 AW962714 AA369277 AA369278 426413 266650 1 AA377823 AW954494 A1022688 426503 268283 1 AA380153 AA380233 AW963529 426531 2687601 AA381071AA381084AA380862 429875 310034 1 A1091815 AA460162 AA460761 430968 326269 1 AW972830 AA527647 AA489820 AA570362 432088 341195 1 AA525454 H74039 R89502 T77379 433532 368950 1 AW975367 AA598607 AA742735 434559 38889_1 AF147315AW173079T53029 435065 399329 1 BE064391 BE064395 AA663613 N99644 436190 41555 1 AK001059 AA633055 436395 41905 1 AJ227900 A1094933 AW051119 F00947 436532 421802 1 AA721522 AW975443 T93070 436722 425758 1 AW975977 AA729469 AA747132 436872 42851-1 X15624 437034 431713 1 AA742643 AA808575 AW976668 439086 46852 1 AF085947 H70981 H78989 439228 47001_1 N51700AF086051 N51792 439518 47334 1 W76326 AF086341 W72300 439546 47360 1 AF088056 W76297 W72448 439566 47387 1 AF086387 W77884 W72711 439710 47550_1 AF086543W96291 W96225 443657 576685 1 R14973 R14967 A1081006 444168 593829 1 AW379879 A1126285 H12014 444386 604004 1 BE065183 A1144398 BE065367 451129 859870_1 BE072881 BE072946AI762181 452712 928309_1 AW838616 AW838660 BE1 4U43 Al914520 AW888910 BE184854 BE 184764 453446 967533 1 BE299996 BE297115 BE270415 BE295214 BE296526 453638 975649 1 AW814996 AL047199 AW850979 453746 979731 1 AL120611 BE006190 BE006189 454377 114761 1 AA076811 AW814764 454389 115682 1 AW752571 AW847602 AA077979 454606 1226149 2 AW809752 AW810271 AW809944 AW810319 AW810215 AW810368 AW810167 454630 1227352_1 BE142075 BE142148 BE142189 AW816249 BE142147 BE142002 BE142406 BE142094 BE142020 BE142074 BE142347 BE142000 BE142375 AW811189 BE142133 454631 1227443 1 AW811324 AW811325 AW811326 AW811333 AW811329 AW811328 AW811332 AW811339 AW811335 454679 1228929 1 AW813110AW813113 454967 1247021 1 AW848276 AW848416 AW848160 AW847945 AW847947 AW848063 AW848113 455023 1249188 1 AW850907 AW850901 AW850877 455302 1276542 1 AW997641 AW891777 455470 1292849_1 AW947992 AW947967 AW947950 AW947957 AW947953 AW947973 AW947966 AW947971 AW947947 AW947970 AW947995 AW947979 AW947952 AW947956 455514 1321649 1 AW983871 BE090302 AW983867 AW983845 AW983860 AW983853 AW983852 455530 1322298 1 AW984744 AW984759 455584 1334741 1 BE007420 BE007419 BE007421 BE007422 455778 1364506 1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 455908 1382301 1 BE156306 BE156188 BE156298 BE156377 BE156374 456072 1470256_1 H54381 H54463 BE393262 456094 1504780 1 H95091 C01228 457374 328758. 1 AA493662AW897396BE154814 457578 359618_-1 AA578027 457730 393905 1 AW753613 AW753857 BE150374 BE150693 BE150394 AA808851 AA650159 AA654653 BE150419 TABLE 25C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et a !.' refers to the publication entitled'The DNA sequence of human chromosome 22-Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_posiGon 400822 7465000 Plus 186223-186402, 186878-187275 400859 9757499 Minus 9188&92018, 98131-98294, 99474-99570 400917 7283186 Minus 173258-173631 400992 8096828 Plus 140390-140822 401012 7230838 Minus 736-1137 401048 7232177 Plus 132430-132761 401125 8570296 Minus 126863-126984 401324 9863791 Plus 234057-234174 401384 6850939 Minus 58360-58545 401558 7139678 Plus 103510-104090 401626 8575943 Minus 238100-238432 401676 9965536 Plus 3891-4691 401714 6715702 Plus 96484-96681 401729 8134856 Minus 90651-90878 401827 2262095 Plus 94725-94860, 98452-98660 401876 8099107 Plus 95913-96641 402028 7139781 Plus 88749-89237 402064 8117294 Plus 100159-100350, 100445-100912 402239 7690131 Plus 38175-38304, 42133-42266 402408 9796239 Minus 110326-110491 402424 9796344 Minus 64925-65073

402516 9798099 Minus 195342-195511 402604 9909420 Plus 20393-20767 402627 9931216 Plus 1213&12272. 16487-16628, 1765¢17798, 18494-18621, 1893319089, 20669-20790, 21134-21298, 22866-22973, 2368&23820, 26626 26895, 29279-29469 402721 8969253 Minus 144428-144715 402798 3355547 Plus 23596-23867 402856 9801288 Minus 90119-90411 403048 4210991 Plus 44275-44592, 49656-49955 403108 8980955 Plus 93253-93667 403142 9444521 Plus 89286-90131 403166 9838127 Minus 67762-67940, 68695-68856, 70394-70507 403478 9958258 Plus 116458-116564 403680 7331517 Minus 157184-157415 403751 7229815 Minus 158794-160929 403790 8084957 Minus 87826-87947, 89835-90002 403797 8099896 Minus 123065-125008 403857 7708910 Minus 2524-3408 403881 7710245 Minus 107250-107685, 108924-109213 403961 7596976 Minus 110393-110603 403969 8569909 Plus 31237-31375, 3240532506 404020 8655966 Minus 174449-174663 404054 3548785 Plus 6671369175 404084 9944055 Plus 2795-2969 404108 8247074 Minus 63603-64942 404170 9930793 Plus 168836-169248 404185 4572584 Minus 129171-129327 404240 5002624 Minus 116132-116407, 116653-116922 404295 9856663 Minus 75747-75947 404299 5738652 Minus 3826-4025 404366 9964977 Plus 96589-96801 404554 7243881 Plus 42637-42839 404561 9795980 Minus 69039-70100 404584 9857511 Plus 138651-139153 404589 9931665 Minus 32824-32985 404642 9796810 Plus 102999-103145 404652 9796969 Minus 108172-108296 404721 9856648 Minus 173763-174294 404756 7706327 Plus 82849-83627 404802 4581357 Minus 30093-30600 404984 6939882 Plus 87221-87505 405159 9966252 Plus 79659-79804 405258 7329310 Plus 129930-130076 405288 6139075 Minus 126268-126436 405353 2811095 Plus 118525-118892 405362 2337862 Minus 105008-105142, 105980-106091, 140445-140556, 142519-142641 405558 1621110 Plus 4502-4644, 5983-6083 405588 5002511 Plus 46180-46366 405605 5836195 Minus 117070117270 405701 4263751 Plus 9324393364 405741 9966947 Minus 156747-156875, 156936-157208 405747 8469069 Minus 153933-154060 405771 7018349 Plus 91191-91254, 91510-91589 405808 9929207 Plus 10975&111166 405884 6758747 Plus 62383-62583 405915 7712162 Minus 43717-43859 406028 8312303 Minus 177469-177829 406085 9123888 Plus 18665-18843 406169 6684220 Minus 12620-14251 406267 7528342 Minus 2570-2731 406326 9212385 Plus 84508-84655 406347 9255981 Plus 90900-91091 406474 9795567 Plus 52758-53211 406577 7711730 Plus 11377-11509 406610 8312226 Plus 13096-13334 TABLE 26A : ABOUT 582 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES Table 26A lists about 582 genes significantly down-regulated in glioblastoma compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymethx/Eos Hu03 GeneChip array such that the ratio of'average'normal CNS to'average'glioblastoma was greater than or equal to 3. The'average'normal CNS level was set to the 75"percentile amongst various normal CNS tissues. The'average'glioblastoma level was set to the 85"'percen6le amongst various tumor samples. In order to remove gene- specific background levels of non-specific hybridization, the 10'"percenGle value amongst various non-malignant Gssues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene GUe R1 : Ratio of 75'"percentile normal central nervous system tissue to 8Sn percenGle tumor Pkey ExAccn UnigenelD Unigene Tite R1 453655 AW960427 Hs. 79059 transforming growth factor, beta recepto 136. 7 417275 X63578 Hs, 295449 parvalbumin 29. 0 430829 AW451999 Hs. 194024 ESTs 25. 7 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 22. 6

419954 D14720 Hs. 93883 myelin protein zero (Charcot-Marie-Tooth 21. 2 459247 N46243 Hs. 110373 ESTs, Highly similar to T42626 secreted 18. 5 416133 NM001683 Hs. 89512 ATPaeSCaHtransporGngplamamembra 15. 5 416018 AW138239 Hs. 78977 proprotein convertase subtilisin/kexin t 15. 2 417167 AW206437 Hs. 4290 ESTs 14. 8 433940 H05129 Hs. 7459 cyclic AMP-regulated phosphoprotein, 21 13. 4 413324 V00571 Hs. 75294 corGcotropin releasing hormone 13. 1 439830 AA846666 Hs. 151489 ESTs, WeakiysimilartoXE7_HUMANPROTEI 12. 6 408068 AW148652 Hs. 167398 ESTs 12. 6 412636 Nom-004415 Hs. 74316 desmoplakin (DPI, DPII) 12. 5 429096 AB011106 Hs. 196012 KIAA0534 protein 12. 2 412638 AA910199 Hs. 203838 ESTs 12. 2 423690 AA329648 Hs. 23804 ESTs, Weakly similar to PN0099 son3 prot 12. 1 456844 Al264155 Hs. 152981 CDP-diacyiglycerol synthase (phosphatida 11. 9 418318 U47732 Hs. 84072 transmembrane4superfamilymember3 10. 9 442593 R39804 Hs. 31961 ESTs 10. 8 446353 A1290919 Hs. 153661 ESTs 10. 4 420290 AW977318 Hs. 194480 ESTs 10. 3 414220 BE298094 gb : 601118231F1 NlH_MGC_17Homosapiensc 10. 3 414290 A1568801 Hs. 71721 ESTs 10. 2 426365 AA376667 Hs. 10283 RNA binding motif protein 88 10. 0 414937 R38698 Hs. 12382 ESTs 10. 0 419643 F06066 Hs. 91791 chromosome 11 open reading frame 25 9. 5 407173 T64349 gb : yc10d08. s1 Stratagene lung (937210) H 9. 5 412454 R55745 Hs. 167330 ESTs 9. 5 439366 AF100143 Hs. 6540 fibroblast growth factor 13 9. 4 415315 F12240 Hs. 250655 prothymosin, alpha (gene sequence 28) 9. 3 441790 AW294909 Hs. 132208 ESTs 9. 2 448117 H49129 Hs. 172982 ESTs 9. 1 400661 9. 0 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheG 9. 0 412453 R20205 Hs. 167330 ESTs 9. 0 408920 AL120071 Hs. 48998 fibronectin leucine rich transmembrane p 8. 9 409031 AA376836 Hs. 76728 ESTs 8. 7 428106 BE620016 Hs. 182470 PTD010 protein 8. 3 446544 A1631932 Hs. 7047 ESTs. Weakly similar to Unknown (H. sapie 8. 2 423479 NM014326 Hs. 129208 death-associated protein kinase 2 8. 2 439480 AL038511 Hs. 125316 ESTs, Weakly similar to S33990 finger pr 8. 2 418036 Z37976 Hs. 83337 latent transforming growth factor beta b 8. 0 456490 U83171 Hs. 97203 small inducible cytokine subfamily A (Cy 8. 0 410200 AA082557 Hs. 101915 Stargardt disease 3 (autosomal dominant) 8. 0 414602 AW630088 Hs. 76550 HomosapiensmRNA ; cDNA DKFZp564Bi 264 (f 8. 0 408428 NM 014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 7. 9 437073 A1885608 Hs. 94122 ESTs 7. 9 408434 AW195317 Hs. 107716 hypothetical protein FLJ22344 7. 9 438150 AA037534 Hs. 79059 transforming growth factor, beta recepto 7. 9 440209 H05049 Hs. 22269 neurexin 3 7. 8 408119 W26213 Hs. 101672 ESTs. WeaklysimilartoT00331 hypotheG 7. 8 417421 AL138201 Hs. 82120 nuclear receptor subfamily 4, group A, m 7. 8 410587 AA370706 Hs. 86412 chromosome 9 open reading frame 5 7. 8 429611 A1889077 Hs. 211388 Homo sapiens BAC clone CTB-60N22 from 7q 7. 7 405800 7. 7 421750 AK000768 Hs. 107872 hypothetical protein FLJ20761 7. 7 426356 BE536836 Hs. 98682 hypothetical protein FKSG32 7. 7 423440 R25234 Hs. 143434 contacGn 1 7. 7 445148 A1214510 Hs. 146304 ESTs 7. 6 416294 D86980 Hs. 79170 KIAA0227 protein 7. 6 424087 N69333 Hs. 143434 contactn 1 7. 6 437479 R61866 Hs. 101277 ESTs 7. 5 405071 7. 5 421224 AW402154 Hs. 125812 ESTs 7. 4 442025 AW887434 Hs. 11810 CDA11 protein 7. 4 459476 BE185844 gb : ILS-HT0731-110500-08708 HT0731 Homo 7. 2 430573 AA744550 Hs. 136345 ESTs 7. 1 401836 7. 1 448958 AB020651 Hs. 22653 KIAA0844 protein 7. 1 430152 AB001325 Hs. 234642 aquaporin 3 7. 1 419474 AW968619 Hs. 155849 ESTs 7. 1 401780 7. 1 446052 AA358760 gb : EST67699 Fetal lung 11 Homo sapiens c 7. 0 423605 AF047826 Hs. 129887 cadhenn 19, hype 2 7. 0 433098 AW190593 Hs. 151143 ESTs 7. 0 449511 A1436187 Hs. 296261 guanine nucleotide binding protein (G pr 6. 9 451285 AW137912 Hs. 227583 HomosapienschromosomeXmapXpil. 23L-6. 8 428414 AL049980 Hs. 184216 DKFZP564C152 protein 6. 8 419273 BE271180 Hs. 293490 ESTs, Weakly similar to 138022 hypotheti 6. 8 443155 R54485 Hs. 23772 ESTs 6. 8 450561 R49674 Hs. 25909 ESTs 6. 8 433068 Nom-006456 Hs. 288215 sialyltransferae 6. 8 440729 AA904739 Hs. 128204 ESTs 6. 8 448426 BE018315 Hs. 280776 tankyrase. TRFi-interacGng ankyrin-reta 6. 7 423589 AA328082 Hs. 209569 ESTs 6. 6 415681 A1379882 Hs. 72630 ESTs 6. 5

413510 F13044 gb : HSC3HH101 normalized infant brain cDN 6. 4 427992 Y15014 Hs. 181353 UDP-Gal : betaGlcNAcbeta1, 3galactosyltr 6. 4 453344 BE349075 Hs. 44571 ESTs 6. 4 450642 R39773 Hs. 7130 copine IV 6. 4 432251 AW972983 Hs. 232165 polycythemia rubra vera 1 ; cell surface 6. 4 429322 D86984 Hs. 199243 KIAA0231 protein 6. 4 444927 AW016637 Hs. 199425 ESTs 6. 4 447482 AB033059 Hs. 18705 KIAA1233 protein 6. 4 400332 S66407 Hs. 248032 FLT4 6. 3 440703 AL137663 Hs. 7378 Homo sapiens mRNA ; cDNA DKFZp434G227 (fr 6. 3 446129 AW244073 Hs. 145946 ESTs 6. 3 454076 AW204712 Hs. 61957 ESTs 6. 3 425526 AA359933 gb : EST69040 Fetal lung 11 Homo sapiens c 6. 3 421913 Api934365 Hs. 109439 osteogtycinfosteoinductive factor, mime 6. 3 434273 AA913143 Hs. 26303 ESTs 6. 2 408480 Api350337 Hs. 164568 fibroblast growth factor 7 (kerafinocyte 6. 2 451301 A1769514 Hs. 209890 EST 6. 2 430754 AW862610 Hs. 157068 ESTs 6. 2 438356 AA805530 Hs. 48527 ESTs 6. 2 422743 BE304678 Hs. 119598 ribosomal protein L3 6. 2 453355 AW295374 Hs. 31412 Homo sapiens CDNA FLJ 11422 fis, clone HE 6. 2 426388 AW081394 Hs. 97103 ESTs 6. 2 452502 Al904296 gb : PM-BT046-tO199-286_1 BT046 Homosapi 6. 1 402546 6. 1 457534 A1761307 Hs. 232226 ESTs 6. 1 408165 AL137573 Hs. 43143 Homo sapiens mRNA ; cDNADKFZp564A2463 (f 6. 1 404958 6. 1 432501 BE546532 Hs. 25682 Homo sapiens mRNA for KIAA1863 protein, 6. 1 442979 AW440782 Hs. 174743 ESTs 6. 1 422262 AL022315 Hs. 113987 lectin, galactoside-binding, soluble, 2 6. 0 408713 NM 001248 Hs. 47042 ectonucleosidetriphosphatediphosphohyd 6. 0 454065 BE394588 gb : 601311808F1 NIH MGC 44 Homo sapiens c 6. 0 430004 U27768 Hs. 227571 regutator of G-protein signalling 4 5. 9 401521 5. 9 425087 R62424 Hs. 126059 ESTs 5. 9 446298 AF187813 Hs. 14637 kidney-and liver-specific gene 5. 9 417761 R13727 Hs. 21435 ESTs 5. 9 424806 AA382523 Hs. 105689 MSTP031 protein 5. 9 441695 T12411 Hs. 183745 hypothetical protein FLJ13456 5. 9 457483 AB034694 Hs. 272558 endomucin-1 5. 9 417175 R44558 Hs. 94002 ESTs 5. 8 437483 AL390174 gb : Homo sapiens mRNA ; cDNA DKFZp547J184 5. 8 436427 A1344378 Hs. 143399 ESTs 5. 8 411939 A1365585 Hs. 146246 ESTs 5. 8 459053 A1807052 Hs. 210361 ESTs 5. 7 411052 AW814950 gb : MR1-ST0206-130400-023dO6ST0206Homo 5. 7 431063 Z98949 Hs. 326843 hypothetical protein bk125H2. 1 5. 7 450382 AA397658 Hs. 60257 Homo sapiens cDNA FLJ 13598 fis, clone PL 5. 7 408478 NM_000806 Hs. 45740 gamma-aminobutyric acid (GABA) A recepto 5. 7 442676 A1733585 Hs. 130897 ESTs 5. 7 446443 AV659082 Hs. 134228 ESTs 5. 7 400865 5. 7 459080 AW192083 Hs. 290855 ESTs 5. 6 407952 A1215902 Hs. 88845 ESTs, Highly similar to T50835 hypotheti 5. 6 431984 AL080239 Hs. 272284 Human DNA sequence from clone GS1-256022 5. 6 425705 AF007833 Hs. 159265 kruppel-related zinc finger protein hcKr 5. 6 442238 AW135374 Hs. 270949 ESTs, Moderately similar to F41925 hypot 5. 6 422994 AW891802 Hs. 296276 ESTs 5. 6 457148 AF091035 Hs. 184627 KIAA0118 protein 5. 6 428356 AL046991 Hs. 10338 ESTs 5. 6 415927 AL120168 Hs. 78919 Kellbloodgroupprecursor (McLeodpheno 5. 5 402092 440526 Al832243 Hs. 211471 ESTs 5. 5 444409 A1792140 Hs. 49265 ESTs 5. 5 417877 A1025829 Hs. 86320 ESTs 5. 4 458238 AW071521 Hs. 333541 beta-amyloid binding protein precursor 5. 4 430702 U56979 Hs. 250651 H factor 1 (complement) 5. 4 456189 H91010 Hs. 44940 ESTs 5. 4 427424 AA402453 Hs. 113011 ESTs 5. 4 437354 AA749215 Hs. 291886 ESTs 5. 4 455617 BE078070 gb : CM1-BT0614-160300-149-f02 BT0614 Homo 5. 4 429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 5. 3 427861 AA813185 Hs. 98183 ESTs 5. 3 408556 U49516 Hs. 46362 5-hydroxytryptamine (serotonin) receptor 5. 3 444209 Al753134 Hs. 146494 ESTs 5. 3 422831 R02504 Hs. 332943 ESTs 5. 3 403180 5. 3 418026 BE379727 Hs. 83213 fatty acid binding protein 4, adipocyte 5. 3 430339 W28608 Hs. 239625 integral membrane protein 2B 5. 2 431596 T34708 Hs. 272927 Sec23 (S. cerevisiae) homolog A 5. 2 431930 AB035301 Hs. 272211 cadherin 7, type 2 5. 2 437403 A1208149 Hs. 121196 ESTs 5. 2 438285 AA782845 Hs. 22790 ESTs 5. 2

439901 N73885 Hs. 124169 ESTs 5. 2 438507 AA809052 Hs. 211275 ESTs 5. 2 449222 AW293984 Hs. 197621 ESTs 5. 2 402834 AK001507 Hs. 306084 HomosapienscloneFLB6914PR01821 mRNA, 5. 2 419042 T81429 Hs. 221065 ESTs 5. 2 436777 AA731199 Hs. 293130 ESTs 5. 2 445071 A1280246 Hs. 149504 ESTs 5. 1 408016 AW136827 Hs. 256096 ESTs 5. 1 412047 AA934589 Hs. 49696 ESTs 5. 1 436953 AW959074 Hs. 23648 Homo sapiens cDNA FU13097 fis, clone NT 5. 1 436773 AW078629 Hs. 82110 PC4 and SFRS1 interacting protein 1 5. 1 409263 AA069573 Hs. 50319 ESTs 5. 1 453830 AA534296 Hs. 20953 ESTs 5. 1 459580 AA022888 Hs. 176065 ESTs 5. 1 417616 R07728 Hs. 268668 ESTs 5. 1 423457 F08208 Hs. 283844 simitar to rat thcarboxyiatecamer-ii 5. 1 441535 AL135735 Hs. 7885 phosphaGdylinositol binding clathrin as 5. 0 416490 AF090116 Hs. 79348 regulator of -protein signalling 7 5. 0 417284 N62889 Hs. 107242 HomosapienscDNAFW12965fis, cloneNT 5. 0 447135 T58148 gb : yb98g06. s1 Stratagene lung (937210) H 5. 0 448605 AL109678 Hs. 21597 Homo sapiens mRNA full length insert cDN 5. 0 442240 A1791883 Hs. 292719 ESTs 4. 9 459399 BE407712 Hs. 153998 creatine kinase, mitochondrial 1 (ubiqui 4. 9 427972 AA864870 Hs. 181304 putative gene product 4. 9 432944 AA570687 Hs. 38512 ESTs 4. 9 440198 BE560093 gb : 601345159F1 NIH_MGC_8 Homo sapiens cD 4. 9 444047 A1097452 Hs. 135095 ESTs 4. 9 416040 AW819158 Hs. 289044 Homo sapiens DNA 12048fis. done HE 4. 9 444922 Al921750 Hs. 144871 Homo sapiens cDNA FU13752 fis, clone PL 4. 8 436670 A1690021 Hs. 201536 ESTs 4. 8 448072 A1459306 Hs. 24908 ESTs 4. 8 408936 AL138043 Hs. 293549 ESTs 4. 8 412622 AW664708 Hs. 171959 ESTs 4. 8 414943 D80647 Hs. 124193 ESTs 4. 8 429254 H10133 Hs. 91846 hypotheticalprotein DKFZp761C121 4. 8 453567 Api742835 Hs. 33368 hypothetical protein FU11175 4. 8 407906 AA369665 Hs. 41185 Homo sapiens mRNA ; cDNA DKFZpS6401262 (f 4. 8 441028 Api333660 Hs. 17558 Homo sapiens cDNA FW14446 fis, clone HE 4. 7 405130 4. 7 455225 AW996689 gb : QV3-BN0046-150400-151-909BN0046Homo 4. 7 446218 AV657159 gb : AV657159 GLC Homo sapiens cDNA clone 4. 7 443347 Al052543 Hs. 133244 melanoma-derived leucine zipper, extra-n 4. 7 402176 4. 7 416577 BE063207 Hs. 79381 grancalcin 4. 7 436221 AK001781 Hs. 296543 Homo sapiens cDNA FLJ10919 fis, clone OV 4. 7 420480 AL137361 Hs. 98173 hypothetical protein 4. 7 400800 Y10262 Hs. 46925 eyes absent (Drosophila) homolog 3 4. 6 435161 AF124150 Hs. 272091 ESTs 4. 6 404793 4. 6 430895 U66581 Hs. 248121 G protein-coupled receptor 22 4. 6 438571 AW020775 Hs. 56022 ESTs 4. 6 445924 A1264671 Hs. 164166 ESTs 4. 6 444585 AW170015 Hs. 6594 ESTs 4. 6 421044 AF061871 Hs. 311736 HumanDNAsequencefromcloneRP1-238D15 4. 6 418274 A1458587 Hs. 128677 Human DNA sequence from clone RP1-50024 4. 6 425475 W56339 Hs. 107057 ESTs 4. 6 434311 BE543469 Hs. 266263 Homo sapiens CDNA FLJ14115 fis, clone MA 4. 5 414272 At651603 Hs. 46988 ESTs 4. 5 445235 A1564022 Hs. 138207 ESTs 4. 5 414327 BE408145 Hs. 185254 ESTs. Weakly similar to T24435 hypotheG 4. 5 414630 BE410857 gb : 601301177F1 NIH_MGC_21 Homosapiensc 4. 5 414456 H74314 gb : yu56el0. r1 Soares fetal liver spleen 4. 5 401024 4. 5 414699 A1815523 Hs. 76930 synuclein, alpha (non A4 component of am 4. 5 423449 A1497900 Hs. 33067 ESTs 4. 5 405138 4. 5 413544 BE147225 gb : PM2-HT022S031299-003-fil HT0225Homo 4. 5 453880 A1803166 Hs. 28462 ESTs, Weakly similar to 138022 hypotheti 4. 5 433521 T66087 Hs. 112482 HomosapiensunknownmRNAsequence 4. 4 441184 AA922009 Hs. 150269 ESTs 4. 4 429876 AB028977 Hs. 225974 KIAA1054 protein 4. 4 445481 AW661846 Hs. 148836 ESTs 4. 4 452340 NM002202 Hs. 505 ISL1 transcripfion factor, LlM/homeodoma 4. 4 404769 4. 4 444331 AW193342 Hs. 24144 ESTs 4. 4 429726 AW628326 Hs. 27151 ESTs 4. 4 449093 AB035356 Hs. 22998 neurexin 1 4. 4 451959 AA056203 Hs. 27337 hypothetica) protein FW20623 4. 4 415716 N59294 Hs. 179662 nucleosome assembly protein 1-like 1 4. 4 417888 R23053 gb : yh31aO5. ri Soares placenta Nb2HP Homo 4. 4 419656 AB002314 Hs. 92025 KIAA0316 gene product 4. 4 425864 U56420 Hs. 159903 olfactory receptor, family 5, subfamily 4. 4 435078 AW518888 Hs. 40937 ESTs 4. 4

413493 BE144444 gb : MRO-HT0168-141199-0o2-fogHTo168Homo 43 432712 AB016247 Hs 288031 sterol-C5-desaturase (fungal ERG3, delta 4. 3 459650 R25754 Hs. 301185 ESTs 4. 3 404828 4. 3 423782 A1472209 Hs. 323117 ESTs 4. 3 426867 AA460967 Hs. 22668 ESTs 4. 3 426802 AA385182 Hs. 46699 ESTs 4. 3 457353 X65633 Hs. 248144 melanocortin 2 receptor (adrenocorticotr 4. 3 412112 BE180342 gb : RC3-HT0622-130400-012-aO7 HT0622 Homo 4. 3 401522 N47812 Hs. 306198 CGI-35 protein 4. 3 419055 A ! 365384 Hs. 11571 HomosapienscDNAFW11570fis, cloneHE 4. 3 410171 H07892 Hs. 12431 ESTs 4. 3 419564 U08989 Hs. 91139 solutecanierfamily1 (neunona'/epiGhe 4. 3 458789 AL157468 Hs. 325825 Homo sapiens cDNA FLJ20848 fis, clone AD 4. 3 455040 AW852286 gb : QVO-CT0225-100400-187-dO8 CT0225 Homo 4. 3 438533 A1440266 Hs. 170673 ESTs, Weakly similar to T24832 hypothefi 4. 3 459005 AA447679 Hs. 144558 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 2 418489 U76421 Hs. 85302 adenosine deaminase, RNA-specific, B1 (h 4. 2 433389 AF038171 gb : Homo sapiens clone 23671 mRNA sequenc 4. 2 454356 AW390363 Hs. 11522 hypotheGcalproteinfromXq28 4. 2 442339 BE299668 Hs. 227591 ESTs, Weakly similar to 1901303A Leu zip 4. 2 421249 AA285362 gb : HTH277 HTCDL1 Hhmo sapiens cDNA 5'I3'4. 2 443998 A1620661 Hs. 296276 ESTs 4. 2 452197 AW023595 Hs. 232048 ESTs 4. 2 451117 AA015752 Hs. 205173 ESTs 4. 2 404501 AW247252 Hs. 75514 nucleoside phosphorylae 4. 2 410378 R23324 Hs. 41693 DnaJ (Hsp40) homolog, subfamily B, membe 4. 2 422528 AB011182 Hs. 118087 KIAA0610 protein 4. 2 440323 AA970614 Hs. 127992 ESTs 4. 1 425767 AF054176 Hs. 159483 chromosome 1 open reading frame 7 4. 1 434460 AA478486 Hs. 3852 KIAA0368 protein 4. 1 410362 H04811 Hs. 93164 proprotein convertase subGlisin/kexin t 4. 1 413121 T96090 Hs. 142678 ESTs 4. 1 409403 AA668224 Hs. 6634 Homo sapiens cDNA : FLJ22547 fis, clone H 4. i 450235 AA007512 Hs. 17538 ESTs 4. 1 449754 H00820 Hs. 30977 ESTs, Weakly similar to B34087 hypotheb 4. 1 421813 BE048255 gb : tz49bO5. yl NCl_CGAP_BmS2Homosapien 4. 1 408496 A1683802 Hs. 136182 ESTs 4. 1 430261 AA305127 Hs. 237225 hypothetical protein HT023 4. 1 434101 AA625205 Hs. 259599 KIAA1622 protein 4. 1 451837 T92157 Hs. 16970 ESTs 4. 1 411772 BE170301 gb : QV4-HT0536-040500-193-fO5HT0536Homo 4. 1 437630 Api252782 Hs. 153026 SWAP-70 protein 4. 1 430212 AA469153 gb : nc67fO4. sl NCl_CGAP_Prl Homo sapiens 4. 0 400216 40 429830 Api537278 Hs. 225841 DKFZP434D193 protein 4. 0 453165 S74727 Hs. 32042 apartoæylae (aminoacylae2, Canavan 4. 0 418047 R37633 Hs. 4847 ESTs 4. 0 405354 4. 0 427931 AW206512 Hs. 186996 ESTs 4. 0 428775 AA434579 Hs. 143691 ESTs 4. 0 449422 AA001373 Hs. 59821 ESTs 4. 0 453864 AW021407 Hs. 21068 hypothetical protein 4. 0 456407 AW968614 gb : EST380690 MAGE resequences, MAGJ Homo 4. 0 441869 Nom003947 Hs. 8004 hunflngun-associated protein interactin 4. 0 420784 T65158 Hs. 102399 ESTs, Moderately similar to S65657 alpha 4. 0 425195 AA352026 Hs. 94319 VPS10 domain receptor protein 4. 0 429628 H09604 Hs. 13268 ESTs 4. 0 410087 F12079 Hs. 332579 ESTs 4. 0 409840 AW502122 gb : UI-HF-BROp-ajr-c-08-0-Ul. rl NIH MGC_5 4. 0 452854 AA437061 Hs. 14060 prokineGcin 1 precursor 4. 0 419910 AA662913 Hs. 190173 ESTs, Weakly similar to A46010 X-linked 4. 0 427443 AA402713 Hs. 97872 ESTs 4. 0 414990 C17758 Hs. 221652 Homo sapiens CDNA FU 14323 fis, clone PL 3. 9 412678 AA115575 Hs. 114914 ESTs 3. 9 405629 3. 9 420299 A1056871 Hs. 15276 ESTs 3. 9 453098 Z25935 Hs. 86379 ESTs 3. 9 435752 AF230801 gb : Homo sapiens growth hormone receptor 3. 9 441005 Z41305 Hs. 303172 Homo sapiens mRNA ; cDNA DKFZp547G133 (fr 3. 9 414516 Al307802 Hs. 135560 ESTs, Weakly similar to T43458 hypotheti 3. 9 442257 AW503831 Hs. 323370 Human EST clone 25267 mariner transposon 3. 9 422563 BE299342 Hs. 19348 hypothetical protein FU13119 3. 9 406697 M21388 Hs. 123017 Human unproducbvely rearranged lg mu-ch 3. 9 443850 AW014723 Hs. 334612 ESTs 3. 9 412677 AW029608 Hs. 17384 ESTs 3. 9 422788 AL117352 Hs. 120828 HumanDNAsequencehomcloneRPS876B10 3. 9 405377 3. 9 414376 BE393856 Hs. 66915 ESTs, Weakly similar to 16. 7Kd protein 3. 9 453341 A1758912 Hs. 296341 adenylyl cyclase-associated protein 2 3. 9 431960 AW241821 Hs. 301927 c6. lA 3. 9 416854 H40164 Hs. 80296 Purkinjecellprotein4 39 427264 AA400117 Hs. 125747 ESTs 3. 9

422746 NM 004484 Hs. 119651 glypican 3 3. 9 452346 BE243534 gb : TCBAPlD0885 Pediatric pre-B ceil æut 3. 9 414666 NM 004466 Hs. 76828 glypican5 3. 8 418217 Al910647 Hs. 13442 ESTs 3. 8 419118 AA234223 Hs. 139204 ESTs 3. 8 445017 Al205493 Hs. 176860 ESTs 3. 8 405867 3. 8 422760 BE409561 gb : 601299865F1 NIH-MGC-21 Homo sapiens c 3. 8 453863 X02544 Hs. 572 orosomucoid 1 3. 8 457821 H47166 Hs. 124322 ESTs, Weakly similar to M7582 B-cell gr 3. 8 457330 AB013818 Hs. 247220 peroxisome biogenesis factor 10 3. 8 435600 AL047034 Hs. 119747 ESTs 3. 8 456083 U46922 Hs. 77252 fragile hisGdine triad gene 3. 8 413341 H78472 Hs. 191325 ESTs, WeaklysimilartoT18967hypotheG 3. 8 449057 AB037784 Hs. 22941 KIAA1363 protein 3. 8 421855 F06504 Hs. 27384 ESTs, Moderately similar to ALU4_HUMAN A 3. 8 414764 AW013887 Hs. 72047 ESTs 3. 8 404391 3. 7 433629 R13140 Hs. 13359 ESTs 3. 7 424738 A1963740 Hs. 46826 ESTs 3. 7 401315 3. 7 407706 AA191085 Hs. 26612 ESTs, Moderately similar to S23650 retro 3. 7 440530 AA888646 Hs. 174187 ESTs 3. 7 433930 AA620338 Hs. 273781 ESTs 3. 7 409662 AW452320 Hs. 279726 ESTs 3. 7 437268 Api754847 Hs. 227571 regulator of G-protein signalling 4 3. 7 445688 A1248205 Hs. 153244 ESTs 3. 7 408593 R19566 Hs. 197617 ESTs 3. 7 417091 AA193283 Hs. 291990 ESTs 3. 7 448556 AW885606 Hs. 5064 ESTs 3. 7 423135 N67655 Hs. 26411 ESTs 3. 7 400135 3. 7 459150 BE155356 gb : PM1-HT0350-160300-009-d06 HT0350 Homo 3. 7 457221 AW383197 Hs. 218260 ESTs 3. 7 451660 A1807927 Hs. 249601 ESTs 3. 7 401600 BE247275 Hs. 151787 U5 snRNP-specific protein, 116 kD 3. 7 446818 A1342668 Hs. 279765 ESTs 3. 7 447795 AW295151 Hs. 163612 ESTs 3. 7 427562 R56424 Hs. 26534 ESTs 3. 6 412258 AA376768 Hs. 324841 hypothe6cal protein FLJ22622 3. 6 454339 AW381980 gb : QV4-HT0316-091199-028-dO5 HT0316 Homo 3. 6 439274 AF086092 Hs. 48372 ESTs 3. 6 452381 H23329 Hs. 290880 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 6 422897 AA679784 Hs. 4290 ESTs 3. 6 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 3. 6 421908 AW935200 Hs. 285814 sprouty (Drosophila) homolog 4 3. 6 407978 AW385129 Hs. 41717 phosphodiesterase 1A, calmodulin-depende 3. 6 426452 AW614271 Hs. 121647 ESTs, HighlysimilartoAC0060148simil 3. 6 400685 3. 6 417154 A1674701 Hs. 21388 ESTs 3. 6 447176 Z42549 Hs. 160893 ESTs 3. 6 423893 AL031709 Hs. 134846 Human DNA sequence from clone 316G12 on 3. 6 449231 BE410360 Hs. 298573 KIAA1720 protein 3. 6 411607 AW853498 gb : RC1-CT0252-170200-02Sh02 CT0252 Homo 3. 6 405977 3. 6 441470 BE503874 Hs. 301986 ESTs 3. 6 423568 NM_005256 Hs. 129818 growth arrest-specific 2 3. 6 441235 Api884586 Hs. 135570 Homo sapiens cDNA : FLJ21268 fis, clone C 3. 6 450236 AW162998 Hs. 24684 KIAA1376 protein 3. 6 425364 AF052150 Hs. 155959 Homo sapiens clone 24533 mRNA sequence 3. 6 426775 AA384564 Hs. 108829 ESTs 3. 6 414831 M31158 Hs. 77439 protein kinase, cAMP-dependent, regulato 3. 6 416876 AW501916 Hs. 117897 ESTs 3. 6 400878 3. 6 425153 AW023193 Hs. 27046 ESTs 3. 6 432222 Api204995 gb : anO3cO3. x1 Stratagene schizo brain S1 3. 5 415047 F13142 gb : HSC3JD031 normalized infant brain cDN 3. 5 401532 3. 5 446495 D60923 Hs. 153460 ESTs 3. 5 431325 AW026751 Hs. 5794 ESTs, Weakly similar to 2109260A Bee) cell 3. 5 445898 AF070623 Hs. 13423 Homo sapiens clone 24468 mRNA sequence 3. 5 455901 BE155527 gb : PMt-HT0350-190400-013-b08 HT0350 Homo 3. 5 416421 AA134006 Hs. 79306 eukaryotic translation initiation factor 3. 5 455697 BE067952 gb : CMO-BT0365-061299-122-g09 BT0365 Homo 3. 5 405678 3. 5 418207 C14685 Hs. 34772 ESTs 3. 5 425383 D83407 Hs. 156007 DownsyndnomecriScalregiongenel-lik 3. 5 417027 AA192306 Hs. 23926 triadin 3 5 408367 AK001178 Hs. 44424 homolog of rat orphan transporter v7-3 3. 5 417702 R09935 Hs. 191146 ESTs 3. 5 445687 W80382 Hs. 149297 ESTs 3 5 408776 AA057365 Hs. 63356 ESTs, Weakly similar to 138022 hypotheU 3. 5 413164 BE068494 gb : MR1-BT0371-050500-009-al2BT0371 Homo 35

414593 BE386764 gb : 601273249F1 NIH MGC 20Homosapiensc 3. 5 453220 AB033089 Hs. 32452 Homo sapiens mRNA for KIAA1263 protein, 3. 5 415621 A1648602 Hs. 55468 ESTs 3. 5 454437 Ai248173 Hs. 191460 hypotheXcal protein MGC12936 3. 5 446066 A1343931 Hs. 149383 ESTs 3. 5 423374 AB037770 Hs. 127656 KIAA1349 protein 3. 5 419347 C15944 Hs. 90005 superiorcervical ganglia, neural specifi 3. 5 418516 NM006218 Hs. 85701 phosphoinositide-3-kinase. catalytic, a) 3. 5 451776 W45679 Hs. 169854 hypothetical protein SP192 3. 5 432305 M62402 Hs. 274313 insulin-like growth factor binding prote 3. 5 456995 T89832 Hs. 170278 ESTs 3. 5 403323 3. 5 425022 M95724 Hs. 154207 centromere protein C 1 3. 5 439394 AA149250 Hs. 56105 ESTs 3. 4 433803 A1823593 Hs. 27688 ESTs 3. 4 450715 A1266484 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 3. 4 411474 AW848427 gb : IL3-CT0214-150200-075-H10CT0214 Homo 3. 4 415076 NM 000857 Hs. 77890 guanylatecyclae 1, soluble, beta3 3. 4 423826 U20325 Hs. 1707 cocaine-and amphetamine-regulated trans 3. 4 459495 BE544158 gb : 601076707F1 HMGC12 Homo sapiens c 3. 4 427173 BE255017 Hs. 97540 ESTs 3. 4 408112 AW451982 Hs. 248613 ESTs 3. 4 446092 N33522 Hs. 145894 ESTs 3. 4 416868 A1656856 Hs. 292597 ESTs 3. 4 458234 BE551408 Hs. 127196 ESTs 3. 4 419555 AA244416 gb : nc07d11. s1 NCI CGAP_Prt Homosapiens 3. 4 414314 BE312991 gb : 601150275FlNIH_MGC_19Homosapiensc 3. 4 400425 AY004252 Hs. 287385 PR domain containing 12 3. 4 414366 BE549143 gb : 601076456F1 NlH_MGC_12Homosapiensc 3. 4 434053 AW445136 Hs. 134946 ESTs 3. 4 449997 A1683052 Hs. 201577 KIAA1829 protein 3. 4 433461 A1636047 Hs. 197623 ESTs 3. 4 428006 AA418743 Hs. 98306 MAA1862 protein 3. 4 424695 U58331 Hs. 151899 sarcoglycan, delta (35kD dystrophin-asso 3. 4 443294 Api733625 Hs. 133053 ESTs 3. 4 428212 AW444451 Hs. 134812 ESTs 3, 4 457673 AA551569 Hs. 272034 hypothetical protein PR02822 3. 4 446390 AA233393 Hs. 14992 hypotheUcalproteinFW11151 3, 3 428536 Al143139 Hs. 2288 visinin-like 1 3. 3 426597 AA382250 Hs. 145601 ESTs 3. 3 410366 A1267589 Hs. 302689 hypothetica) protein 3. 3 458258 AW406546 Hs. 127971 ESTs 3. 3 401738 3. 3 409038 T97490 Hs. 50002 small inducible cytokine subfamily A (Cy 3. 3 425785 T27017 Hs. 159528 Homo sapiens clone 24400 mRNA sequence 3. 3 433328 AW298159 Hs. 23644 ESTs, Weakly similar to S65824 reverse t 3. 3 414541 BE293116 Hs. 76392 aldehyde dehydrogenase 1 family, member 3. 3 434998 AW975157 Hs. 26037 ESTs 3. 3 456359 Al967991 Hs. 93574 homeo box D3 3. 3 426527 NM 001037 Hs. 170238 sodium channel, voltage-gated, type 1, b 3. 3 454267 AA437199 Hs. 656 cell division cycle 25C 3. 3 400302 N48056 Hs. 1915 folate hydrolase (prostate-specific memb 3. 3 434077 AF116659 Hs. 321151 HomosapiensPR01412mRNA, complelecos 33 436602 At793222 Hs. 166817 ESTs 3. 3 449204 AB000099 Hs. 23251 Down syndrome critical region gene 4 3. 3 417935 R53697 Hs. 170044 ESTs 3. 3 423310 AA325225 Hs. 124023 Homo sapiens cDNA FLJ14218 fis, clone NT 3. 3 436624 T64297 Hs. 5241 fatty acid binding protein 1, liver 3. 3 453406 A1192987 Hs. 61784 hypothetical protein FU14451 3. 3 420164 AW339037 Hs. 24908 ESTs 3. 3 447826 AW779317 Hs. 258556 ESTs 3. 3 419875 AA853410 Hs. 93557 proenkephalin 3. 3 444612 AW138111 Hs. 22902 ESTs 3. 3 418504 BE159718 Hs. 85335 Homo sapiens mRNA ; cDNADKFZp564D1462 (f 3. 2 415242 R45986 Hs. 295014 ESTs 3. 2 418188 AW139413 Hs. 151880 ESTs 3. 2 430355 NM 006219 Hs. 239818 phosphoinosiXde-3kinase, catalytic. be 3. 2 421640 AW966652 gb : EST378726 MAGE resequences, MAGI Homo 3. 2 432359 AA076049 Hs. 274415 Homo sapiens cDNA FLJ10229 fis, clone HE 3. 2 408806 AW847814 Hs. 289005 Homo sapiens cDNA : FU21532 fis, clone C 3. 2 400409 AF153341 Hs. 283954 Homo sapiens winged helix/forkhead trans 3. 2 446015 T30968 Hs. 13531 hypothetical protein FLJ10971 3. 2 425495 AA358454 Hs. 78026 ESTs, Weakly similar to similar to ankyr 3. 2 403092 3. 2 452971 A1873878 Hs. 91789 ESTs 3. 2 454186 BE141030 gb : MRO-HT0067-201099-002-h11HT0067Homo 3. 2 401485 3. 2 401949 3. 2 457452 AW972675 gb : EST384766 MAGE resequences, MAGL Homo 3. 2 454100 Al693231 Hs. 126043 chromosome 21 open reading frame 51 3. 2 448440 AA173467 Hs. 62402 p21/Cdc42/Ræ1-ætivaled kinae 1 (yeast 3. 2 421200 AA284811 Hs. 264433 ESTs 3. 2 430142 NM_000437 Hs. 234392 platelet-acbvatng factor acetylhydrola 3. 2

433197 AB040889 Hs. 281022 KIAA1456 protein 3. 2 443509 AV645470 gb : AV645470 GLC Homo sapiens cDNA clone 3. 2 440827 Api733110 Hs. 128128 ESTs 3. 2 432799 NM 016161 Hs. 278960 alpha-1, 4-N-acetylglucosaminyltransferas 3. 2 409257 AW370362 gb : RC1-BT025S181099-012-dO7BT0255Homo 3. 2 459235 BE246010 Hs. 271468 Homo sapiens mRNA for FLJ00033 protein, 3. 2 416789 AA223439 Hs. 79933 cydin 1 3. 2 429809 AL162010 Hs. 223603 Homo sapiens mRNA ; cDNADKFZp761D09121 (3. 2 420156 AW449258 Hs. 6187 ESTs 3. 2 455577 BE006341 gb : RC2-BN0127-240300-011-b05BN0127Homo 3. 2 400617 AF151064 Hs. 36069 hypothetical protein 3. 2 437129 AL049327 Hs. 302057 Homo sapiens mRNA ; cDNA DKFZp564E016 (fr 3. 2 451820 AW058357 Hs. 337353 ESTs 3. 2 457535 AA609685 Hs. 278672 membrane component, chromosome 11, surfa 3. 2 419956 AL137939 Hs. 40096 ESTs 3. 1 456235 AA203637 gb : zx58bl2. rl Soares_fetal-liver-spleen-3. 1 423930 AA332697 Hs. 42721 ESTs 3. 1 403796 3. 1 414085 AA114016 Hs. 75746 aldehyde dehydrogenase 1 family, member 3. 1 445886 Api793176 Hs. 145596 ESTs 3. 1 414401 A1760159 Hs. 124833 ESTs 3. 1 441573 BE563966 Hs. 6529 ESTs, Weakly similar to 178885 serine/th 3. 1 450725 R71389 Hs. 175951 ESTs 3. 1 458805 Api282933 Hs. 23294 hypothetical protein FU14393 3. 1 417868 A1078534 Hs. 122592 ESTs 3. 1 458391 A1792628 Hs. 133273 ESTs 3. 1 423346 A1267677 Hs. 127416 synaptoianin 1 3. 1 454486 AW857077 gb : RC1-CT0302-140300-016-f04CT0302Homo 3. 1 408341 AW182952 Hs. 249957 ESTs 3. 1 410669 AW805749 Hs. 318885 supenoxidedismutte2, mitochondrisl 3, 1 404907 3. 1 434910 A1333863 Hs. 215474 ESTs, Moderately similar to alternativel 3. 1 436990 A1149729 Hs. 120557 ESTs 3. 1 441921 A1733376 Hs. 164478 hypotheUcaproteinFW21939similarto 3. 1 454673 AW812807 gb : RC3-ST0186-070100-016-c04 ST0186 Homo 3. 1 429470 A1878901 Hs. 203862 guaninenudeotidebindingprotein (Gpr 3. 1 404345 AA730407 Hs. 159156 protocadherin 11 3. 1 408217 Al433201 Hs. 279860 tumor protein, translationally-controlle 3. 1 417313 AA195602 gb : zr32f09. rl Soares NhHMPu S1 Homo sapi 3. 1 427322 AK002017 Hs. 176227 hypothetical protein FLJ11155 3. 1 411003 AA181018 Hs. 13056 hypothetical protein FLJ13920 3. 1 425339 AA936330 Hs. 198113 ESTs 3. 1 426716 Nom006379 Hs. 171921 sema domain, immunoglobulin domain (1g), 3. 1 449078 AK001256 Hs. 22975 KIAA1576 protein 3. 1 429608 U49250 Hs. 210862 T-box, brain, 1 3. 1 442308 AA989402 Hs. 111 fibroblast growth factor 9 (gliaactivat 3. 1 428465 AW970976 Hs. 293653 ESTs 3. 1 411666 AF106564 Hs. 71346 neurofilament 3 (150kD medium) 3. 1 447965 AW292577 Hs. 94445 ESTs 3. 1 413918 AW015898 Hs. 71245 ESTs 3. 1 419682 H13139 Hs. 92282 paired-like homeodomain transcription fa 3. 1 425810 A1923627 Hs. 31903 ESTs 3. 1 427865 AA416931 Hs. 126065 ESTs 3. 1 429060 AW139155 Hs. 194995 hypothetical protein DKFZp43400320 3. 1 430708 U78308 Hs. 278485 olfactory receptor, family 1, subfamily 3. 1 448084 A1467800 Hs. 271000 ESTs, Weakly similar to 138022 hypotheti 3. 1 454506 AW847346 gb : RCO-CT020S240999-021-eO1 CT0205 Homo 3. 1 414629 AA345824 Hs. 76688 carboxylesterase 1 (monocyte/macrophage 3. 0 422963 M79141 Hs. 13234 ESTs 3. 0 417696 BE241624 Hs. 82401 CD69 antigen (p60, eady T-cell xGvati 3. 0 448175 BE296174 Hs. 225160 hypothetical protein FLJ13102 3. 0 414686 BE409757 Hs. 23189 ESTs, Moderately similar to TBB2_HUMAN T 3. 0 458360 A1027207 Hs. 132253 ESTs 3. 0 451829 AW964081 Hs. 247377 ESTs 3. 0 445179 A1949743 Hs. 224768 ESTs 3. 0 433090 A1720050 Hs. 145362 immortalization-upregulated protein 3. 0 432018 AA524447 Hs. 152377 ESTs 3. 0 407988 N47760 Hs. 285107 hypothetical protein FU 13397 3. 0 405911 3. 0 418808 Al821836 Hs. 10359 ESTs 3. 0 431900 AW972048 Hs. 192534 ESTs 30 452893 H18017 Hs. 22869 ESTs, Moderately similar to KIAA1395 pro 3. 0 423952 AW877787 Hs. 136102 KIAA0853 protein 3. 0 412000 AW576555 Hs. 15780 ATP-binding cassette, sub-family A (ABC1 3. 0 405793 3. 0 410711 AB002316 Hs. 65746 KIAA0318 protein 3. 0 411279 AW884776 gb : QV4-OT0067-010300-121-d01 OT0067 Homo 3. 0 423957 AW978309 Hs. 136235 Homo sapiens CDNA FU 13542 fis, clone PL 3. 0 427071 AA397958 Hs. 192719 ESTs 3. 0 434961 AW974956 gb : EST387061 MAGE resequences, MAGN Homo 3. 0 TABLE 26B : Pkey : Unique Eos probeset identifier number

CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 409257 1112994 1 AW370362 AW809101 409840 1156071 1 AW502122 AW502125 AW501663 AW501720 411052 1230374_1 AW814950 R98513 H69459 BE176242 H54583 411279 1237516 1 AW884776 AW935737 AW835261 AW835247 AW835246 AW835263 AW835240 AW835258 411474 1247047_2 AW848427 AW848890 AW848159 AW848118 AW848634 AW848285AW848086 AW848485 AW848283 AW848162 411607 1251251_1 AW853498AW853442 AW853590 AW853433 AW853592 411772 1257386_1 BE170301 AW861539 AW904351 BE154336 BE154090 BE154275 412112 12778831 BE180342 BE180347 AW901900 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE180228 AW901897 BE180224 AW901898 BE180223 BE180219 BE180346 BE180343 BE180418 BE180225 BE180221 BE180341 AW901894 BE180217 BE180227 AW901891 BE180345 AW893614 AW893615 H85799 H83501 BE180220 413164 1351422_1 BE068494 BE068414 BE068332 BE068347 BE068706 BE068623 BE068450 BE068480 BE068350 BE068295 BE068498 BE068765 BE068328 BE068778 BE068671 BE068526 BE068493 BE068433 BE068740 BE068306 BE068631 BE068580 BE068445 BE068567 BE068521 BE068549 BE068392 BE068307 BE068692 BE068473 BE068754 8E068476 BE068685 BE068626 BE068591 BE068745 BE068434 BE068759 BE068628 BE068723 BE068529 BE068689 BE068383 BE068422 BE068470 BE068522 BE068618 BE068354 BE068748 BE068683 BE068303 BE068602 BE068739 BE068374 BE068302 BE068625 BE068596 BE068663 BE068429 BE068605 BE068693 BE068672 BE068401 BE068579 BE068329 BE068390 BE068419 BE068393 BE068447 BE068675 BE068311 BE068540 BE068301 BE068543 BE068719 BE068369 BE068324 BE068588 BE068568 BE068317 BE068384 BE068547 BE068674 BE068436 BE068321 BE068361 BE068676 BE068499 BE068299 BE068352 BE068410 BE068293 BE068418 BE068552 BE068598 BE068327 BE068550 BE068712 BE068661 BE068733 BE068525 BE068752 BE068357 BE068330 BE068565 BE068538 BE068340 BE068537 BE068761 BE068632 BE068758 413493 1373555 1 BE144444 BE144430 413510 1374377 1 F13044 T77009 BE145525 BE145493 413544 1375671 BE147225BE147205BE147234 414220 1426940_1 BE298094 BE267860 414314 1435028_1 BE312991 BE272945 414366 1438636 1 BE549143 BE390613 BE277344 414456 1447655 1 H74314 BE299593 414593 1464909_1 BE336764 BE387560 414630 1468083-1 BE410857 BE390605 415047 1517450 1 F13142 Z42926 F06135 F06147 H08517 D51360 T75341 417313 1666441 AA195602W01148 N40632 417888 1706092 1 R23053 R79884 R76271 419555 1858841 AA244416AA244401 421249 20064991 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204833 1 AW966652 AW966653 AA294989 AA385977 421813 207654_1 BE043255M313083M293419 422760 221034_1 BE409561 BE162756AW732798 425526 252776 1 AA359933 AA358889 AW955306 AW962995 AW837746 AW837755 AW837697 430212 314437 1 AA469153 A1718503 AA469225 432222 343347 1 AI204995 AW827539 AW969908 AW440776 AA528756 433389 36497 1 AF038171 Z43209 F07347 434961 396357_1 AW974956 M781075 M654944 435752 41050 1 AF230801 AF230800 AA401795 AA398260 437483 43756 1 AL390174 AW898817 440198 48824-2 BE560093 443509 57199 1 AV645470 T84636 T82805 446052 65988 1 AA358760 AA158850 AW062737 AW062738 AV656291 446218 66686 1 AV657159 BE145509 BE145512 BE145505 BE145507 447135 70963 1 T58148 AW516579 AW059603 452346 912206_1 BE243534 BE243752 A1880228 L44326 452502 919733 1 A1904296 BE007223 R30687 454065 998401 1 BE394588 AW024754 BE183166 BE183167 454186 1049791J BE141030BE141474BE141467BE141753BE141024BE141761AW177583AW17 7579AW177582AW177585AW177587AW807582AW177581 BE141477 BE141520 BE141456 BE141492 BE141028 BE141775 BE141489 BE141751 AW177599 BE141750 AW177597 BE141512 BE141460 BE141749 AW177598 454339 1122972J AW381980BE152244BE152235BE152238BE152232 454486 1215703 1 AW857077AW861268AW847383AW795787 454506 1219857_1 AW847346 AW847395 AW847408 AW847385 AW847342 AW847396 AW847339AW801718 AW801787 454673 1228669_1 AW812807AW812815AW812802 455040 1250028 1 AW852286 AW851934 AW852096 AW852274 455225 1262318_1 AW996689 AW996380 AW996453 BE085650 AW868687 BE085595 455577 1333898 1 BE006341 BE006307 BE006311 455617 1346117 1 BE078070 BE061030 BE077927 455697 1351148 1 BE067952 BE067945 BE067942 BE067943 BE067949 BE067954 BE067944 BE067953 BE067956 BE067946 455901 1381569_1 BE155527 BE155503 BE155188 BE155126 456235 168686 1 AA203637 AA832266 H67452 456407 184986_1 AW968614M243209M281411 457452 339381_1 AW972675M541366M523039 459150 919196_1 BE155356 BE153488 BE153461 BE155059 BE155210 BE155413 BE153577 BE153688 BE155063 BE155347 A1903640 BE155492 TABLE 26C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (Gl) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 2Y Dunham, et ail. (1999) Nature 402 : 483495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucteotide positions of predicted exons. Pkey Ref Strand Nt_positon 400661 8118474 Plus 84912-85187 400685 8118768 Minus 72969-73050, 73713-73800

400865 1945037 Minus 44482-45526 400878 9864757 Plus 3149332842 401024 8117489 Plus 60551-60802 401315 9212516 Minus 198960-199619 401485 7341723 Plus 68009-68209, 68841-69077 401521 7705251 Plus 9127-9234 401532 7798785 Plus 124414-124950, 125050-125418 401738 2982169 Minus 41547-41757 401780 7249190 Minus 28397-28617, 28920 29045, 2913S29296, 29411-29567, 2970S29787, 30224-30573 401836 7534063 Plus 71981-72084 401949 3492889 Plus 160726-161660 402092 7249154 Minus 107533-108094 402176 7543687 Minus 10-750 402546 7637348 Plus 24673-25170 403092 8954241 Plus 174720-175016, 175104-175406. 175508-175813 403180 7523976 Minus 63603-63759 403323 8348082 Minus 120366-120845 403796 8099896 Minus 75073-77664 404391 3135305 Minus 26030-26173, 27852-27997 404769 8099713 Minus 175801-176823 404793 7232206 Minus 61087-61590 404828 6580415 Minus 26291-27253 404907 7331453 Minus 102880-103828 404958 7407941 Minus 2731-4531 405071 7708797 Minus 11115-11552 405130 8516045 Plus 150235-150449 405138 8576241 Plus 9030390516 405354 2642452 Plus 52213-53089 405377 5649375 Plus 216656-216848 405629 4508116 Minus 101678-101866 405678 4079670 Plus 151821-152027 405793 1405887 Minus 89197-89453 405800 2791346 Plus 19271-19813 405867 6758731 Minus 74553-75173 405911 6758795 Plus 101008-101643 405977 8247789 Minus 135548-136177 TABLE 27A ABOUT 533 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES Table 27A lists about 533 CNS-ennched genes significantly down-regulated in glioblastoma compared to normal adult CNS tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of *average'normal CNS to'average* glioblastoma was greater than or equal to 2. The average-normal CNS level was set to the 75'"percentile amongst various normal CNS tissues. The'average'glioblastoma level was set to the 85 percentile amongst various tumor samples. To enrich for CNS specific genes, the ratio of'average CNS to'average'non-CNS normal adult tissues was calculated to be greater than or equal to 2. The'average CNS level was set to the 85b percentile amongst various CNS tissues. The'average'normal non-CNS adult tissue level was set to the 85"'percenGle amongst various non-CNS normal tissues. In order to remove gene-specific background levels of non-specific hybridization, the 10'"percenfile value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratios were evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene Gtle R1 : Ratio of 751, percentile normal central nervous system tissue to 85"percenti) e tumor R2 : Ratio of 85"'percentile central nervous system tissue to 85'^ percen6te nortnal body tissue Pkey ExAccn UnigenelD Unigene Title R1 R2 417275 X63578 Hs. 295449 parvalbumin 29. 0 30. 0 430829 AW451999 Hs. 194024 ESTs 25. 7 6. 2 410657 AF063228 Hs. 65248 dynein, cytoplasmic, intermediate polype 22. 6 25. 8 419954 D14720 Hs. 93883 myelin protein zero (Charcot-Marie-Tooth 21. 2 30. 3 416133 NM001683 Hs. 89512 ATPase, CaetransporGng, plamamembra 15. 5 16. 8 416018 AW138239 Hs. 78977 proprotein convertase subtilisin/kexin t 15. 2 18. 0 417167 AW206437 Hs. 4290 ESTs 14. 8 17. 7 433940 H05129 Hs. 7459 cyclic AMP-regulated phosphoprotein, 21 13. 4 18. 1 413324 V00571 Hs. 75294 corticotropin releasing hormone 13. 1 18. 0 439830 AA846666 Hs. 151489 ESTs, WeakiysimilartoXE7_HUMANPROTEI 12. 6 16. 5 408068 AW148652 Hs. 167398 ESTs 12. 6 16. 9 429096 AB011106 Hs. 196012 KIAA0534 protein 12. 2 21. 1 412638 AA910199 Hs. 203838 ESTs 12. 2 16. 0 442593 R39804 Hs. 31961 ESTs 10. 8 15. 0 446353 A1290919 Hs. 153661 ESTs 10. 4 13. 2 426365 AA376667 Hs. 10283 RNA binding motif protein 8B 10. 0 5. 9 414937 R38698 Hs. 12382 ESTs 10. 0 10. 8 419643 F06066 Hs. 91791 chromosome 11 open reading frame 25 9. 5 10. 9 412454 R55745 Hs. 167330 ESTs 9. 5 14. 1 439366 AF100143 Hs. 6540 fibroblast growth factor 13 9. 4 12. 3 441790 AW294909 Hs. 132208 ESTs 9. 2 3. 2 448117 H49129 Hs. 172982 ESTs 9. 1 12. 8 433558 AA833757 Hs. 201769 ESTs, Weakly similar to T24435 hypotheG 9. 0 14. 7 412453 R20205 Hs. 167330 ESTs 9. 0 13. 7 408920 AL120071 Hs. 48998 fibronectin leucine rich transmembrane p 8. 9 17. 3 409031 AA376836 Hs. 76728 ESTs 8. 7 8. 6 446544 Al631932 Hs. 7047 ESTs, Weakly similar to Unknown (H. sapie 8. 2 20. 0 439480 AL038511 Hs. 125316 ESTs, Weakly similar to 33990 finger pr 8. 2 8. 3 410200 AA082557 Hs. 101915 Stargardt disease 3 (autosomal dominant) 8. 0 8. 9

408428 NM014787 Hs. 44896 DnaJ (Hsp40) homolog, subfamily B, membe 7. 9 9. 6 437073 A1885608 Hs. 94122 ESTs 7. 9 11. 3 408434 AW195317 Hs. 107716 hypothetical protein FU22344 7. 9 16. 4 440209 H05049 Hs. 22269 neurexin 3 7. 8 34. 3 408119 W26213 Hs. 101672 ESTs Weakly similar to T00331 hypotheti 7. 8 9. 0 429611 AI889077 Hs. 211388 Homo sapiens BAC clone CTB-60N22 from 7q 7. 7 5. 0 423440 R25234 Hs. 143434 contactin 1 7. 7 9. 9 445148 A ! 214510 Hs. 146304 ESTs 7. 6 9. 1 416294 D86980 Hs. 79170 KIAA0227 protein 7. 6 7. 6 424087 N69333 Hs. 143434 contactin 1 7. 6 10. 3 437479 R61866 Hs. 101277 ESTs 7. 5 9. 3 430573 AA744550 Hs. 136345 ESTs 7. 1 2. 8 448958 A8020651 Hs. 22653 KIAA0844 protein 7. 1 10. 4 419474 AW968619 Hs. 155849 ESTs 7. 1 3. 0 423605 AF047826 Hs. 129887 cadherin 19, type 2 7. 0 6. 9 433098 AW190593 Hs. 151143 ESTs 7. 0 9. 2 449511 Ai436187 Hs. 296261 guanine nucleoGde binding protein (G pr 6. 9 3. 1 428414 AL049980 Hs. 184216 DKFZP564C152protein 6. 8 5. 0 443155 R54485 Hs. 23772 ESTs 6. 8 3. 5 450561 R49674 Hs. 25909 ESTs 6. 8 8. 1 433068 NM006456 Hs. 288215 sialyltransferase 6. 8 2. 0 423589 AA328082 Hs. 209569 ESTs 6. 6 10. 5 415681 A1379882 Hs. 72630 ESTs 6. 5 9. 0 413510 F13044 gb : HSC3HH101 normalized infant brain cDN 6. 4 7. 1 427992 Y15014 Hs. 181353 UDP-Ga': betaGlcNAcbeta1, 3galætosyltr 6. 4 9. 5 450642 R39773 Hs. 7130 copine IM 6. 4 5. 7 429322 D86984 Hs. 199243 KIAA0231 protein 6. 4 8. 2 447482 AB033059 Hs. 18705 KIAA1233 protein 6. 4 2. 3 446129 AW244073 Hs. 145946 ESTs 6. 3 8. 3 421913 Api934365 Hs. 109439 osteoglycin (osteoinducEve factor, mime 6. 3 2. 1 434273 AA913143 Hs. 26303 ESTs 6. 2 10. 3 408480 A (350337 Hs. 164568 fibroblast growth factor 7 (keratinocyte 6. 2 3. 5 451301 A1769514 Hs. 209890 EST 6. 2 12. 4 438356 AA805530 Hs. 48527 ESTs 6. 2 8. 1 426388 AW081394 Hs. 97103 ESTs 6. 2 8. 6 452502 A1904296 gb : PM-BT046-220199-286 1 BT046 Homo sapi 6. 1 2. 8 408165 AL137573 Hs. 43143 Homo sapiens mRNA ; cDNA DKFZp564A2463 (f 6. 1 6. 3 442979 AW440782 Hs. 174743 ESTs 6. 1 6. 3 408713 Nom-001248 Hs. 47042 ectonucleosidetriphosphatediphosphohyd 6. 0 3. 8 430004 U27768 Hs. 227571 regulator of G-protein signalling 4 5. 9 21. 4 425087 R62424 Hs. 126059 ESTs 5. 9 8. 1 441695 T12411 Hs. 183745 hypothetical protein FLJ13456 5. 9 3. 1 417175 R44558 Hs. 94002 ESTs 5. 8 12. 5 437483 AL390174 gb : Homo sapiens mRNA ; cDNADKFZp547J184 5. 8 2. 2 436427 A1344378 Hs. 143399 ESTs 5. 8 13. 8 450382 AA397658 Hs. 60257 Homo sapiens cDNA FW13598 fis, clone PL 5. 7 4. 4 408478 NM 000806 Hs. 45740 gamma-aminobutyric acid (GABA) A recepto 5. 7 12. 5 442676 Al733585 Hs. 130897 ESTs 5. 7 6. 8 446443 AV659082 Hs. 134228 ESTs 5. 7 6. 4 459080 Au) 92083 Hs. 290855 ESTs 5. 6 15. 6 431984 AL080239 Hs. 272284 Human DNA sequence from clone GS1-256022 5. 6 8. 2 428356 AL046991 Hs. 10338 ESTs 5. 6 6. 2 417877 A1025829 Hs. 86320 ESTs 5. 4 4. 9 429290 AF203032 Hs. 198760 neurofilament, heavy polypeptide (200kD) 5. 3 13. 1 408556 U49516 Hs. 46362 5-hydroxytryptamine (serotonin) receptor 5. 3 6. 6 431930 AB035301 Hs. 272211 cadherin 7, hype 2 5. 2 6. 0 438285 AA782845 Hs. 22790 ESTs 5. 2 7. 3 439901 N73885 Hs. 124169 ESTs 5. 2 2. 7 449222 AW293984 Hs. 197621 ESTs 5. 2 8. 1 408016 AW136827 Hs. 256096 ESTs 5. 1 2. 5 436953 AW959074 Hs. 23648 Homo sapiens cDNA 3097fis. done NT 5. 1 3. 0 436773 AW078629 Hs. 82110 PC4 and SFRS1 interacting protein 1 5. 1 7. 3 409263 AA069573 Hs. 50319 ESTs 5. 1 12. 9 453830 AA534296 Hs. 20953 ESTs 5. 1 3. 4 441535 AL135735 Hs. 7885 phosphatidylinositol binding clathrin as 5. 0 4. 8 416490 AF090116 Hs. 79348 regulator of G-protein signailing 7 5. 0 20. 1 417284 N62889 Hs. 107242 Homo sapiens cDNA FU12965 fis, clone NT 5. 0 3. 9 448605 AL109678 Hs. 21597 Homo sapiens mRNA full length insert cDN 5. 0 6. 1 442240 A1791883 Hs. 292719 ESTs 4. 9 6. 7 427972 AA864870 Hs. 181304 putative gene product 4. 9 5. 2 416040 AW819158 Hs. 289044 Homo sapiens CDNA FU 12048 fis, clone HE 4. 9 2. 8 444922 A1921750 Hs. 144871 Homo sapiens cDNA FLJ 13752 fis, clone PL 4. 8 3. 7 408936 AL138043 Hs. 293549 ESTs 4. 8 6. 6 414943 D80647 Hs. 124193 ESTs 4. 8 3. 1 429254 H10133 Hs. 91846 hypotheGcalprotein DKFZp761C121 4. 8 2. 3 407906 AA369665 Hs. 41185 Homo sapiens mRNA ; cDNA DKFZp56401262 (f 4. 8 9. 1 416577 BE063207 Hs. 79381 grancalcin 4. 7 2. 2 420480 AL137361 Hs. 98173 hypothetical protein 4. 7 2. 8 404793 4. 6 2. 2 430895 U66581 Hs. 248121 G protein-coupled receptor 22 4. 6 7. 4 438571 AW020775 Hs. 56022 ESTs 4. 6 5. 4 444585 AW170015 Hs. 6594 ESTs 4. 6 6. 0 414272 A1651603 Hs. 46988 ESTs 4. 5 2. 2

414699 Api815523 Hs. 76930 synuclein, alpha (non A4 component of am 4. 5 30. 9 423449 A1497900 Hs. 33067 ESTs 4. 5 20. 8 433521 T66087 Hs. 112482 HomosapiensunknownmRNAsequence 4. 4 2. 0 429876 AB028977 Hs. 225974 KIAA1054 protein 4. 4 19. 2 429726 AW628326 Hs. 27151 ESTs 4. 4 10. 2 449093 AB035356 Hs. 22998 neurexin 1 4. 4 9. 4 415716 N59294 Hs. 179662 nucleosome assembly protein 1-like 1 4. 4 15. 1 419656 AB002314 Hs. 92025 KIAA0316 gene product 4. 4 8. 2 425864 U56420 Hs. 159903 olfactory receptor, family 5, subfamily 4. 4 2. 4 435078 AW518888 Hs. 40937 ESTs 4. 4 5. 7 432712 AB016247 Hs. 288031 sterol-CSdesaturase (fungal ERG3, delta 4. 3 5. 9 426867 AA460967 Hs. 22668 ESTs 4. 3 6. 0 412112 BE180342 gb : RC3-HT0622-130400-012-a07 HT0622 Homo 4. 3 3. 2 410171 H07892 Hs. 12431 ESTs 4. 3 5. 3 442339 BE299668 Hs. 227591 ESTs, Weakly similar to 1901303A Leu zip 4. 2 5. 0 421249 AA285362 gb : HTH277 HTCDLI Homo sapiens CDNA 5rS 4. 2 3. 5 422528 AB011182 Hs. 118087 KIAA0610 protein 4. 2 3. 9 434460 AA478486 Hs. 3852 KIAA0368 protein 4. 1 8. 3 410362 H04811 Hs. 93164 proprotein convertase subtilisin/kexin t 4. 1 7. 0 449754 H00820 Hs. 30977 ESTs, Weakly similar to B34087 hypotheb 4. 1 3. 9 408496 A1683802 Hs. 136182 ESTs 4. 1 4. 7 434101 AA625205 Hs. 259599 KIAA1622 protein 4. 1 6. 3 430212 AA469153 gb : nc67f04. sl NCl_CGAP_Prl Homo sapiens 4. 0 2. 5 453165 S74727 Hs. 32042 aspartoacylase (aminoæyEae 2, Canavan 4. 0 7. 4 456407 AW968614 gb : EST380690 MAGE resequences, MAGJ Homo 4. 0 5. 1 441869 NM003947 Hs. 8004 huntingUn-associated protein interaction 4. 0 32. 3 429628 H09604 Hs. 13268 ESTs 4. 0 4. 5 410087 F12079 Hs. 332579 ESTs 4. 0 6. 9 419910 AA662913 Hs. 190173 ESTs, Weakly similar to A46010 X-linked 4. 0 2. 6 441005 Z41305 Hs. 303172 Homo sapiens mRNA ; cDNA DKFZp547G133 (fr 3. 9 21. 7 412677 AW029608 Hs. 17384 ESTs 3. 9 2. 2 453341 A1758912 Hs. 296341 adenylyl cyclase-associated protein 2 3. 9 7. 2 416854 H40164 Hs. 80296 Purkinjecellprotein4 3. 9 2. 2 414666 NM004466 Hs. 76828 glypican 5 3. 8 6. 2 418217 A1910647 Hs. 13442 ESTs 3. 8 3. 2 421855 F06504 Hs. 27384 ESTs, ModeratelysimilartoALU4_HUMANA 3. 8 2. 2 414764 AW013887 Hs. 72047 ESTs 3. 8 10. 7 433629 R13140 Hs. 13359 ESTs 3. 7 2. 7 424738 A1963740 Hs. 46826 ESTs 3. 7 2. 1 407706 AA191085 Hs. 26612 ESTs, Moderately similar to S23650 retro 3. 7 5. 3 437268 A1754847 Hs. 227571 regulator of G-protein signalling 4 3. 7 53. 7 423135 N67655 Hs. 26411 ESTs 3. 7 21. 7 446818 A1342668 Hs. 279765 ESTs 3. 7 2. 6 427562 R56424 Hs. 26534 ESTs 3. 6 3. 6 439274 AF086092 Hs. 48372 ESTs 3. 6 34. 5 452381 H23329 Hs. 290880 ESTs, Weakly similar to ALU1_HUMAN ALU S 3. 6 6. 0 422897 AA679784 Hs. 4290 ESTs 3. 6 5. 1 429656 X05608 Hs. 211584 neurofilament, light polypeptide (68kD) 3. 6 24. 6 417154 AI674701 Hs. 21388 ESTs 3. 6 5. 8 447176 Z42549 Hs. 160893 ESTs 3. 6 6. 4 405977 3. 6 3. 9 423568 NM005256 Hs. 129818 growth arrest-specific 2 3. 6 2. 5 441235 Api884586 Hs. 135570 Homo sapiens cDNA : FLJ21268 fis, clone C 3. 6 5. 4 426775 AA384564 Hs. 108829 ESTs 3. 6 3. 4 414831 M31158 Hs. 77439 proteinkinase, cAMP-dependent, ngulato 3. 6 2. 8 425153 AW023193 Hs. 27046 ESTs 3. 6 4. 9 446495 D60923 Hs. 153460 ESTs 3. 5 9. 8 445898 AF070623 Hs. 13423 Homosapiensdone24468mRNAsequence 3. 5 16. 6 416421 AA134006 Hs. 79306 eukaryotictransiation initiation factor 3. 5 5. 0 418207 C14685 Hs. 34772 ESTs 3. 5 16. 0 425383 D83407 Hs. 156007 Downsyndromecnticalregiongenel-lik 3. 5 6. 2 417027 AA192306 Hs. 23926 badin 3. 5 2. 5 408367 AK001178 Hs. 44424 homologofratorphantransporterv7-3 3. 5 5. 3 408776 AA057365 Hs. 63356 ESTs, Weakly similar to 138022 hypotheti 3. 5 5. 5 453220 AB033089 Hs. 32452 Homo sapiens mRNA for KIAA1263 protein, 3. 5 23. 6 419347 C15944 Hs. 90005 superiorcervical ganglia, neural specifi 3. 5 42. 3 433803 A1823593 Hs. 27688 ESTs 3. 4 3. 6 450715 Al266484 Hs. 31570 ESTs, WeaklysimilartoKIM1324protein 3. 4 4. 1 415076 NM_000857 Hs. 77890 guanylate cyclase 1, soluble, beta 3 3. 4 9. 8 423826 U20325 Hs. 1707 cocaine-and amphetamine-regulated trans 3. 4 4. 7 427173 BE255017 Hs. 97540 ESTs 3. 4 2. 4 446092 N33522 Hs. 145894 ESTs 3. 4 3. 5 416868 A1656856 Hs. 292597 ESTs 3. 4 4. 5 458234 BE551408 Hs. 127196 ESTs 3. 4 4. 5 434053 AW445136 Hs. 134946 ESTs 3 4 3 9 428536 A1143139 Hs. 2288 visinin-like 1 3. 3 42. 3 410366 At267589 Hs. 302689 hypothetical protein 3. 3 14. 4 425785 T27017 Hs. 159528 Homosapiensclone24400mRNAsequence 3. 3 4. 6 434998 AW975157 Hs. 26037 ESTs 3. 3 4. 7 456359 AI967991 Hs. 93574 homeo box D3 3. 3 4. 4 426527 NM 001037 Hs. 170238 sodium channel, voltage-gated, type 1, b 3. 3 5. 2 400302 N48056 Hs. 1915 folate hydrolase (prostate-specific memb 3. 3 9. 0 419875 AA853410 Hs. 93557 proenkephalin 3. 3 3. 6

444612 AW138111 Hs. 22902 ESTs 3. 3 3. 0 415242 R45986 Hs. 295014 ESTs 3. 2 2. 2 421640 AW966652 gb : EST378726 MAGE resequences, MAGI Homo 3. 2 3. 8 408806 AW847814 Hs. 289005 Homo sapiens cDNA : FLJ21532 fis, clone C 3. 2 2. 4 446015 T30968 Hs. 13531 hypothetical protein FU10971 3. 2 3. 2 425495 AA358454 Hs. 78026 ESTs, Weakly similar to similar to ankyr 3. 2 2. 2 403092 3. 2 2. 9 452971 A1873878 Hs. 91789 ESTs 3. 2 4. 5 454100 A1693231 Hs. 126043 chromosome 21 open reading frame 51 3. 2 2. 7 448440 AA173467 Hs. 62402 p21/Cdc42/Rac1-activatedkinase1 (yeast 3. 2 2. 8 421200 AA284811 Hs. 264433 ESTs 3. 2 2. 7 440827 A1733110 Hs. 128128 ESTs 3. 2 2. 1 429809 AL162010 Hs. 223603 HomosapiensmRNA, cDNADKFZp761D09121 (3. 2 4. 3 420156 AW449258 Hs. 6187 ESTs 3. 2 19. 0 457535 AA609685 Hs. 278672 membrane component, chromosome H. surfa 3. 2 2. 0 419956 AL137939 Hs. 40096 ESTs 3. 1 8. 7 423930 AA332697 Hs. 42721 ESTs 3. 1 2. 7 417868 A1078534 Hs. 122592 ESTs 3. 1 12. 6 423346 A1267677 Hs. 127416 synaptojanin 1 3. 1 12. 0 441921 Api733376 Hs. 164478 hypothetical protein FU21939 similar to 3. 1 4. 3 429470 Al878901 Hs. 203862 guanine nucleotide binding protein (G pr 3. 1 5. 3 408217 Api433201 Hs. 279860 tumor protein, transiatonally-controlle 3. 1 7. 1 427322 AK002017 Hs. 176227 hypothefical protein FU11155 3. 1 6. 3 449078 AK001256 Hs. 22975 KIAA1576 protein 3. 1 30. 1 429608 U49250 Hs. 210862 T-box, brain, 1 3. 1 2. 2 442308 AA989402 Hs. 111 fibrobiatgrowthfætor9 (glia-æGvat 31 30 411666 AF106564 Hs. 71346 neunofilament3 (150kDmedium) 31 10. 9 427865 AA416931 Hs. 126065 ESTs 3. 1 7. 5 430708 U78308 Hs. 278485 olfactory receptor, family 1, subfamily 3. 1 3. 4 451829 AW964081 Hs. 247377 ESTs 3. 0 6. 2 405911 3. 0 2. 4 418808 Api821836 Hs. 10359 ESTs 3. 0 6. 2 452893 H18017 Hs. 22869 ESTs, Moderately similar to KIAAL 395 pro 3. 0 5. 1 423952 AW877787 Hs. 136102 KIAA0853 protein 3. 0 2. 1 412000 AW576555 Hs. 15780 ATP-bindingsasette, sub-familyA (ABC1 3. 0 2. 1 405793 3. 0 2. 7 410711 AB002316 Hs. 65746 KIAA0318 protein 3. 0 14. 3 427071 AA397958 Hs. 192719 ESTs 3. 0 2. 1 453534 Nom314796 Hs. 33187 KIAA0748 gene product 3. 0 14. 5 413903 AA496493 Hs. 23136 ESTs 3. 0 2. 2 426866 U02330 Hs. 172816 neuregulin 1 3. 0 11. 3 434945 AB033065 Hs. 4280 KIAA1239 protein 3. 0 3. 5 412639 AW961284 Hs. 296235 ESTs 2. 9 4. 9 453590 AF150278 Hs. 33578 KIAA0820 protein 2. 9 33. 1 414502 AL133721 Hs. 224680 ESTs 2. 9 2. 3 434367 AB020700 Hs. 3830 KIAA0893 protein 2. 9 23. 1 425121 A1797511 Hs. 154679 synaptotagminl 2. 9 8. 1 412494 AL133900 Hs. 792 ADP-ribosylaGonfætordomainproteinl 2. 9 20. 8 401213 2. 9 3. 2 401028 AW673312 Hs. 50848 hypothetical protein FLJ20331 2. 9 3. 4 415191 AA190381 Hs. 120810 ESTs 2. 9 3. 0 449275 AW450848 Hs. 205457 periaxin 2. 9 5. 6 419863 AW952691 Hs. 93485 HomosapiensmRNA, cDNADKFZp761D191 (fr 2. 9 35. 0 411421 BE272110 Hs. 21177 ESTs 2. 9 2. 0 430865 A1073424 Hs. 5232 HSPC125 protein 2 9 11. 4 437486 AW952089 Hs. 5636 RAB6A, member RAS oncogene family 2. 9 2. 2 442357 A1458586 Hs. 135706 ESTs 2. 9 6. 0 408274 R17315 gb : yg12g11. r1Soaresinfantbrain1NIBH 2. 9 2. 2 444185 AW298350 Hs. 66020 ESTs 2. 8 5. 0 420173 AA256151 Hs. 22999 ESTs 2. 8 5. 1 428358 AA993222 Hs. 101915 Stargardt disease 3 (autosomal dominant) 2. 8 7. 0 447252 R90916 Hs. 12449 HomosapienstransmembraneproteinHTMP1 2. 8 4. 4 440260 A1972867 Hs. 7130 copine IV 2. 8 10. 6 417084 H08370 Hs. 33067 ESTs 2. 8 8. 4 438257 AW474419 Hs. 224794 ESTs 2. 8 2. 8 441934 T23939 Hs. 7344 ESTs 2. 8 6. 2 447885 F11528 Hs. 303172 HomosapiensmRNA ; cDNADKFZpS47G133 (fr 28 35 423552 AF107028 Hs. 129783 sodium channel, voltage-gated, type 11, 2. 8 3. 4 450940 A1744943 Hs. 143209 ESTs, Weakly similar to 138022 hypothefi 2. 8 14. 4 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 2. 8 21. 7 445887 A1263105 Hs. 145597 ESTs 2. 8 5. 1 425494 N55540 Hs. 78026 ESTs, Weakly similar to similar to ankyr 2. 8 2. 4 438202 AW169287 Hs. 22588 ESTs 2. 8 11. 9 436199 R38946 Hs. 127951 hypothetical protein FU14503 2. 8 6. 0 434826 AF155661 Hs. 22265 pynuvate dehydrogenase phosphatase 2. 8 2. 4 415462 R52692 Hs. 12698 ESTs 2. 8 3. 4 418070 NM 000844 Hs. 83407 glutamate receptor, metabotropic 7 2. 8 4. 5 432149 AW614326 Hs. 157022 ESTs, Weakly similar to T34549 probable 2. 8 9. 5 430371 D87466 Hs. 240112 KIAA0276 protein 2. 8 7. 0 437357 AL359559 Hs. 331666 HomosapiensmRNA ; cDNADKFZp76202215 (f 2. 7 2. 5 415838 R44336 Hs. 7093 ESTs 2. 7 3. 6 438675 AA813725 Hs. 213568 ESTs 2. 7 2. 5 419558 AW953679 gb : EST365749 MAGE resequences, MAGC Homo 2. 7 31

446318 AI949389 Hs. 18067 ESTs 2. 7 4. 1 445183 AB007877 Hs. 12385 KIAA0417 gene product 2. 7 5. 3 457012 R41480 Hs. 127630 ESTs 2. 7 19. 0 431988 AC002302 Hs. 77202 protein kinase C, beta 1 2. 7 7. 2 430223 NM 002514 Hs. 235935 nephroblastoma overexpressed gene 2. 7 2. 8 447932 AA837474 Hs. 20021 vesicle-associated membrane protein 1 (s 2. 7 3. 8 450214 BE439763 Hs. 227571 regulator of G-protein signalling 4 2. 7 6. 9 434731 AA648049 Hs. 121518 ESTs 2. 7 5. 0 428839 Al767756 Hs. 82302 Homo sapiens cDNA FW14814 hs, clone NT 2. 7 5. 2 407709 AA456135 Hs. 23023 ESTs 2. 7 2. 5 422420 U03398 Hs. 1524 tumor necrosis factor (ligand) superfami 2. 7 3. 3 443305 A1050693 Hs. 133318 ESTs 2. 7 5. 9 435648 H24347 Hs. 27524 ESTs 2. 7 15. 0 418407 AL044818 Hs. 84928 nuclear transcription factor Y, beta 2. 7 2. 7 436771 AW975687 Hs. 292979 ESTs 2. 7 6. 0 428689 NM_014351 Hs. 189810 sulfortranferase family 4A, member 1 2. 7 4. 8 440503 NM 006539 Hs. 7235 calcium channel, voltage-dependent, gamm 2. 7 4. 4 441006 AW605267 Hs. 7627 CGI-60 protein 2. 7 3. 1 410330 AW023630 Hs. 46786 ESTs 2. 6 29. 5 434398 AA121098 Hs. 3838 serum-inducible kinase 2. 6 2. 6 438831 BE263273 Hs. 6439 synapsin 11 2. 6 7. 8 419066 Z98492 Hs. 6975 PR01073protein 2. 6 3. 4 412643 AW971239 Hs. 293982 ESTs 2. 6 2. 2 430456 AA314998 Hs. 241503 hypothetical protein 2. 6 17. 9 416498 U33632 Hs. 79351 potassium channel, subfamily K, member 1 2. 6 2. 9 401421 2. 6 2. 0 419530 X98330 Hs. 90821 ryanodine receptor 2 (cardiac) 2. 6 4. 2 441817 AW969706 Hs. 293332 ESTs 2. 6 3. 8 439203 AA448930 Hs. 8453 KIAA1587 protein 2. 6 4. 2 426054 U12431 Hs. 166109 ELAV (embryonic lethal, abnormal vision, 2. 6 5. 1 444583 AW994403 Hs. 100861 hypotheGcal protein FLJ 14600 2. 6 3. 7 417919 A1928203 Hs. 86379 ESTs 2. 6 3. 0 434293 NM004445 Hs. 3796 EphB6 2. 6 3. 2 431716 D89053 Hs. 268012 fatty-acid-Coenzyme A ligase, long-chain 2. 6 6. 4 443037 AW500305 Hs. 299166 syntaxin 7 2. 6 2. 2 440736 D56919 Hs. 265848 myomegalin 2. 6 7. 1 404648 2. 6 3. 0 429995 AA463571 gb : zx72e09. rl Soares_total_fetus_Nb2HF8_ 2. 6 3. 5 436508 AW604381 Hs. 121121 ESTs, Weakly similar to S00755 pleckstri 2. 6 3. 9 441190 H09073 Hs. 25046 ESTs 2. 6 3. 1 432278 AL137506 Hs. 274256 hypothetical protein FU23563 2. 6 2. 9 442731 A1868167 Hs. 131044 ESTs 2. 6 4. 1 416836 D54745 Hs. 80247 cholecystokinin 2. 6 14. 9 449071 NM005872 Hs. 22960 breast carcinoma amplified sequence 2 2. 5 2. 4 436321 AA709133 Hs. 180144 ESTs 2. 5 2. 8 439693 A1741816 Hs. 125897 ESTs 2. 5 3. 6 443212 AW269515 Hs. 102500 hypothetical protein FLJ20481 2. 5 2. 8 423981 AL122104 Hs. 136664 Homo sapiens mRNA ; cDNA DKFZp434A1627 (f 2. 5 3. 8 407868 NM 000950 Hs. 40637 proline-nch Gla (Gcarboxyglutamic acid 2. 5 3. 1 443992 AW022228 Hs. 322922 ESTs 2. 5 27. 9 444124 R43097 Hs. 6818 ESTs 2. 5 5. 3 411379 Al816344 Hs. 12554 ESTs, WeaklysimilartoNPL4_HUMANNUCLE 2. 5 38. 0 440474 Api207936 Hs. 7195 gamma-aminobutyric acid (GABA) A recepto 2. 5 3. 8 446277 Ai284218 Hs. 159204 ESTs 2. 5 2. 2 410111 Al620206 Hs. 189647 ESTs 2. 5 3. 5 445162 AB011131 Hs. 12376 piccolo (presynapticcytomatrixprotein) 2. 5 4. 8 410718 Api920783 Hs. 191435 ESTs 2. 5 4. 5 417201 T60432 Hs. 269084 ESTs, Moderately similar to AF0979994 L 2. 5 2. 9 420274 AW968000 Hs. 143389 ESTs, Weakly similar to T14318 ubiquitin 2. 5 2. 8 433496 AF064254 Hs. 49765 VLCS-H1 protein 2. 5 4. 7 437331 AL353933 Hs. 21710 hypothetical protein DKFZp761G0313 2. 5 3. 3 437368 Al471969 Hs. 182606 ESTs 2. 5 3. 0 441985 BE047625 Hs. 169815 ESTs 2. 5 3. 6 410025 BE220489 Hs. 1 13592 ESTS, Moderately similar to 154374 gene 2. 5 9. 2 414680 AA743331 Hs. 272572 hemoglobin, alpha 2 2. 5 3. 6 429956 A1374651 Hs. 22542 ESTs 2. 5 23. 9 429028 AA443439 Hs. 48797 ESTs 2. 5 2. 8 438109 A1076621 Hs. 71367 ESTs, Moderately similar to ALU7 HUMAN A 2. 5 3. 1 439780 AL109688 gb : Homo sapiens mRNA full length insen 2. 5 2. 3 440888 N45600 Hs. 326880 ESTs 2. 5 3. 9 445246 A1217713 Hs. 147586 ESTs 2. 5 2. 6 440152 AB002376 Hs. 7006 KIAA0378 protein 2. 4 23. 6 432740 AF061034 Hs. 278898 tumor necrosis factor alpha-inducible ce 2. 4 2. 1 415122 D60708 Hs. 22245 ESTs 2. 4 3. 9 432298 AL118812 Hs. 274293 HomosapiensmRNA ; cDNADKFZp761G1111 (f 2. 4 9. 8 437948 AA772920 Hs. 303527 ESTs 2. 4 9. 8 421360 AA297012 Hs. 103839 erythrocyte membrane protein band 4. 1-li 2. 4 2. 8 427115 AW972853 Hs. 112237 ESTs 2. 4 2. 2 452074 BE299035 Hs. 27747 G protein-coupled receptor 37 (endotheli 2. 4 10. 0 436639 D14338 Hs. 111 fibrobiast growth factor 9 (g) ia-activat 2. 4 3. 5 434520 AA205273 Hs. 177011 hypothetical protein 2. 4 3. 1 411529 AA430348 Hs. 317596 Homo sapiens cDNA FW12927 fis, clone NT 2. 4 3. 0 442272 AA988302 Hs. 129172 ESTs 2. 4 2. 1

422927 AW247388 Hs. 301423 calcium binding protein 1 (calbrain) 2. 4 2. 7 444647 H14718 Hs. 11506 Humanclone23589mRNAsequence 2. 4 2. 8 415827 H17462 Hs. 23079 ESTs 2. 4 15. 0 451397 AA017432 Hs. 84529 ESTs, WeaklysimilartoZ202_HUMANZINC 2. 4 3. 9 445200 AA084460 Hs. 12409 somatostatin 2. 4 3. 7 451062 AL110125 Hs. 25910 Homo sapiens mRNA ; cDNA DKFZp564C1416 (f 2. 4 2. 4 420328 Y19062 Hs. 96870 staufen (Drosophila, RNA-binding protein 2. 4 4. 3 432122 AA526514 gb : ni60fO2. sl NCl_CGAP_Ov2 Homo sapiens 2. 4 4. 3 444125 Al124882 Hs. 118121 ESTs 2. 4 3. 5 430538 AB032435 Hs. 242821 differentiation-associated Na-dependent 2. 4 10. 8 457519 X69438 Hs. 3052 early growth response 4 2. 4 2. 4 409371 R51736 Hs. 12381 ESTs 2. 4 2. 1 456303 AA224872 Hs. 115088 ESTs 2. 4 3. 2 440105 AA694010 Hs. 6932 Homosapiensclone23809mRNAsequence 2. 4 23. 4 400979 2. 4 4. 1 435296 R49685 Hs. 24980 ESTs 2. 4 6. 5 408950 AA707814 Hs. 14945 long fatty acyl-CoA synthetase 2 gene 2. 4 18. 5 452032 BE244005 Hs. 27610 retnoic acid-and interferon-inducible 2. 4 2. 2 432098 AF252297 Hs. 91546 cytochrome P450 retinoid metabolizing pr 2. 4 2. 7 408974 AW015458 Hs. 297017 ESTs 2. 4 2. 5 412177 Z23091 Hs. 73734 glycoprotein V (platelet) 2. 4 2. 8 413153 N94205 gb : za27aO8. r1 Soares fetal liver spleen 2. 4 2. 5 417583 AA668782 Hs. 191284 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 4 2. 6 452034 F12234 Hs. 75893 ankyrin3, nodeofRanvier (ankyrinG) 2. 3 3. 0 424940 AA985308 Hs. 194327 ESTs 2. 3 6. 3 431706 At816086 Hs. 296341 adenylyf cyclase-associated protein 2 2. 3 4. 1 419125 AA642452 Hs. 130881 B-cellCLL/lymphoma11A (zincfingerpro 2. 3 2. 9 423641 AL137256 Hs. 130489 ATPase, aminophospholipid transporter-) ! 2. 3 8. 7 436407 T88803 Hs. 271507 ESTs, Weakly similar to TIM_HUMAN PROBAB 2. 3 3. 2 448681 AL109781 Hs. 21754 Homo sapiens mRNA full length insert cDN 2. 3 5. 2 415669 NM 005025 Hs. 78589 sedne (orcysteine) proteinaseinhibito 2. 3 54. 7 410765 A1694972 Hs. 66180 nucleosomeasemblyprotein 1-like2 2. 3 9. 1 422386 AF105374 Hs. 115830 heparansulfate (glucosamine) 3-0-sulfot 2. 3 5. 0 414828 AA156651 gb : zlO5hO5. r1 SoarespregnantuterusNbH 2. 3 2. 4 445556 Al910241 Hs. 12887 æún-related protein 3-beta 2. 3 8. 5 426968 U07616 Hs. 173034 amphiphysin (Stiff-Mann syndrome with br 2. 3 26. 3 444562 AA186715 Hs. 336429 RIKEN cDNA 9130422N19 gene 2. 3 2. 5 423420 Api571364 Hs. 128382 HomosapiensmRNA ; cDNADKFZp76111224 (f 2. 3 7. 6 439450 R51613 Hs. 125304 ESTs 2. 3 26. 3 427127 AW802282 Hs. 22265 pyruvate dehydrogenase phosphatase 2. 3 2. 2 447179 AW015633 Hs. 157299 ESTs 2. 3 3. 8 414711 A1310440 Hs. 288735 Homo sapiens cDNA FLJ 13522 fis, clone PL 2. 3 2. 3 433449 AW772282 gb : hn71b05. x1NCLCGAPKid11Homosapien 2. 3 3. 8 414320 U13616 Hs. 75893 ankyrin3, nodeofRanvier (ankyrinG) 2. 3 2. 5 416778 M16505 Hs. 79876 steroid sulfatase (microsomal), arylsulf 2. 3 7. 8 425130 AA448208 Hs. 99163 ESTs 2. 3 4. 1 456664 AW963354 Hs. 334409 metallothionein 1G 2. 3 2. 5 438283 A1458931 Hs. 37282 ESTs 2. 3 4. 2 417455 AW007066 Hs. 18949 ESTs. WeaklysimilartoCA2B_HUMANCOLLA 2. 3 3. 0 412100 AW892731 gb : CMO-NNOOOSf00300-279-c02 NN0005 Homo 2. 3 3. 7 448981 A1968719 Hs. 195387 ESTs 2. 3 3. 2 416101 R24854 Hs. 268806 ESTs 2. 3 6. 5 439731 A1953135 Hs. 45140 hypothetical protein FLJ14084 2. 3 17. 8 415734 NM014747 Hs. 78748 KIAA0237 gene product 2. 3 40. 1 424596 AB020639 Hs. 151017 estrogen-related receptor gamma 2. 3 2. 9 420230 AL034344 Hs. 284186 forkhead box C1 2. 3 2. 4 451559 AL119980 Hs. 20935 hypotheticalprotein DKFZp761D221 2. 3 5. 7 404835 2. 3 2. 1 456765 A1497900 Hs. 33067 ESTs 2. 3 4. 1 455517 AW984068 gb : RCO-HN0006-160300-011-eO6HN0006Homo Z3 2. 4 408206 AF041853 Hs. 43670 kinesin family member 3A 2. 2 18. 5 411770 NM_014278 Hs. 71992 healshockprolan (hsp110family) 2. 2 3. 9 430105 X70297 Hs. 2540 cholinergic receptor, nicotinic, alpha p 2. 2 2. 6 458694 F12832 Hs. 13298 ESTs 2. 2 4. 9 415091 AL044872 Hs. 77910 3-hydroxy-3-methylglutaryl-CoenzymeAsy 2. 2 4. 4 439642 W81441 Hs. 153967 ESTs 2. 2 2. 4 450138 AW152104 Hs. 200879 ESTs 2. 2 4. 9 454222 BE144344 Hs. 7589 ESTs, Weakly similar to A46010 X-linked 2. 2 3. 7 405326 2. 2 2. 7 431342 AW971018 Hs. 21659 ESTs 2. 2 5. 2 453101 AW952776 Hs. 94943 ESTs 2. 2 3. 3 408897 N50204 Hs. 283709 lipopolysacchaide specific response-7 p 2. 2 2. 8 451398 A1793124 Hs. 144479 ESTs 2. 2 4. 6 438208 AL041224 Hs. 65379 ESTs 2. 2 10. 4 408449 NM004408 Hs. 166161 dynamin 1 2. 2 6. 1 414130 AI670831 Hs. 71592 HomosapienscDNA : FLJ21893 fis, clone H 2. 2 3. 1 445016 U79716 Hs. 12246 reelin 2. 2 3. 9 424375 AF070547 Hs. 146312 Homosapiensclone24820mRNAsequence 2. 2 2. 3 424645 NM014682 Hs. 151449 KIAA0535 gene product 2. 2 11. 7 409729 D51315 Hs. 106289 ESTs 2. 2 4. 9 432809 AA565509 Hs. 131703 ESTs 2. 2 19. 9 422890 Z43784 Hs. 75893 ankyr 3, node of Ranvier (ankyrin G) 2. 2 10. 4 428532 AF157326 Hs. 184786 TBP-interacting protein 2. 2 6. 5

413074 A1871368 Hs. 8417 hypothetical protein DKFZp761M0423 2. 2 3. 4 414442 AA156238 Hs. 32501 ESTs 2. 2 3. 2 452768 AW069459 Hs. 61539 ESTs 2. 2 2. 0 450440 AB024334 Hs. 25001 tyrosine 3-monooxygenaselUyptophan 5-mo 2. 2 3. 2 426281 AK000987 Hs. 169111 oxidationresistancet 2. 2 2. 3 428411 AW291464 Hs. 10338 ESTs 2. 2 2. 3 413787 Api352558 Hs. 75544 tyrosine 3monooxygenase/Uyptophan 5-mo 2. 2 3. 1 451734 NM 006176 Hs. 26944 neurogranin (protein kinase C substrate, 2. 2 8. 5 439108 AW163034 Hs. 6467 synaptogyrin 3 2. 2 7. 9 405385 2. 2 2. 4 447285 Api371849 Hs. 200696 ATPase, Gass VI, type 11C 2. 2 2. 2 452667 T87219 Hs. 13219 ESTs 2. 2 3. 1 422234 AF119818 Hs. 113287 discs, large (Drosophila) homolog-associ 2. 1 8. 3 410339 A1916499 Hs. 298258 ESTs 2. 1 3. 2 413231 D87461 Hs. 75244 BCL2-like 2 2. 1 4. 5 447104 R19085 Hs. 210706 Homo sapiens CDNA FU 13182 fis, clone NT 2. 1 2. 2 451952 AL120173 Hs. 301663 ESTs 2. 1 36. 5 415841 Z45637 Hs. 7093 ESTs 2. 1 2. 4 441086 Api928489 Hs. 213490 ESTs, Weakly similar to N33_HUMAN N33 PR 2. 1 2. 2 450407 NM_000810 Hs. 24969 gamma-aminobutyric acid (GABA) A recepto 2. 1 6. 6 427627 R87582 Hs. 179915 guanine nucleoEde binding protein (G pr 2. 1 5. 3 449712 R56545 Hs. 6100 ESTs 2. 1 4. 5 409660 AW452065 Hs. 258905 ESTs 2. 1 2. 1 430434 AL049548 Hs. 241420 Homo sapiens mRNA for KIAA1756 protein, 2. 1 5. 4 434138 AA625804 gb : zu86hO1. s1 Soares_tesGs_NHTHomosap 2. 1 3. 0 448610 NM 006157 Hs. 21602 net (chicken)-like 1 2. 1 4. 8 418948 A1217097 gb : qd43hO7. x1 Soares_feW_hearl_NbHH19W 2. 1 2. 9 414876 AW950925 Hs. 924 crystallin, mu 2. 1 3. 4 440426 A1159800 Hs. 7181 HomosapienscDNAFW13663fis, clonePL 2. 1 3. 7 451249 AA016227 Hs. 27280 ESTs 2. 1 4. 1 451475 T19093 Hs. 26450 KIAA0725 protein 2. 1 2. 1 448743 AB032962 Hs. 21896 KIAAL 136 protein 2. 1 29. 7 430814 U89336 Hs. 247993 NG5 protein 2. 1 2. 7 426990 AL044315 Hs. 173094 Homo sapiens mRNA for KIAA1750 protein, 2. 1 2. 3 426642 AW068223 Hs. 171581 ubiquitin C-terminal hydrolase UCH37 2. 1 4. 5 427335 AA448542 Hs. 251677 G antigen 7B 2. 1 2. 2 459089 F13036 Hs. 27373 Homo sapiens mRNA ; cDNADKFZp56401763 (f 2. 1 2. 3 435832 AA425688 Hs. 41641 Bruno (Drosophila)-like 4, RNA binding 2. 1 5. 9 446383 T05816 Hs. 92511 ESTs 2. 1 2. 9 412768 AW996044 Hs. 26239 HumanDNAsequencefromcloneRP11-438B2 2. 1 2. 1 453976 BE463830 Hs. 163714 ESTs 2. 1 4. 2 415111 R39039 Hs. 328455 EST 2. 1 3. 3 452238 F01811 Hs. 187931 ESTs 2. 1 4. 9 445279 R41900 Hs. 22245 ESTs 2. 1 9. 8 448799 Api937094 Hs. 179080 ESTs 2. 1 3. 1 418338 NM002522 Hs. 84154 neuronal pentraxin 1 2. 1 8. 3 445725 AK000956 Hs. 13209 hypothetical protein FLJ10094 2. 1 5. 4 443537 D13305 Hs. 203 cholecystokinin B receptor 2. 1 4. 1 454066 X00356 Hs. 37058 calcitonin/calcitonin-related polypeptid 2. 1 6. 4 429954 A1918130 Hs. 21374 ESTs 2. 1 7. 2 415292 H29016 Hs. 200576 ESTs 2. 1 3. 9 423563 R34734 Hs. 75209 protein kinae (cAMP-dependent, catalyti 2. 1 3. 1 424906 AI566086 Hs. 153716 Homo sapiens mRNA for Hmob33 protein, 3'2. 1 4. 7 459309 AA040620 Hs. 5672 hypothetical protein AF140225 2. 1 2. 2 439340 AB032436 Hs. 6535 brain-specific Na-dependent inorganic ph 2. 1 4. 7 402598 BE314624 Hs. 3128 polymerase (RNA) 11 (DNA directed) polyp 2. 1 5. 4 435406 F26698 Hs. 4884 calcium/calmodulin-dependent protein kin 2. 1 6. 6 448792 R42550 Hs. 12826 ESTs 2. 1 4. 1 449500 AW956345 Hs. 12926 ESTs 2. 1 2. 4 441134 W29092 Hs. 7678 cetiuiarretinoicacid-binding protein 1 2. 1 5. 8 433361 AW469373 Hs. 300141 ribosomal protein L39 2. 1 2. 7 452946 X95425 Hs. 31092 EphA5 2. 1 5. 0 426167 AF039023 Hs. 167496 RAN binding protein 6 2. 0 2. 2 453666 AW015681 Hs. 135229 ESTs, WeaklysimilartoA2BP_HUMANATAXI 2. 0 3. 1 424632 AB014523 Hs. 151406 KIAA0623 gene product 2. 0 3. 5 448589 AF017090 Hs. 21554 KIAA1107 protein 2. 0 4. 1 430416 AC005531 Hs. 57806 Homo sapiens PAC clone RP4-701016 from 7 2. 0 2. 3 445627 AW818475 Hs. 7363 ESTs 2. 0 2. 1 417092 H97508 Hs. 181165 eukaryotic translation elongation factor 2. 0 2. 5 453653 AW505554 Hs. 144559 ESTs 2. 0 4. 7 435850 AF250847 Hs. 283514 mitochondrial ceramidase 2. 0 3. 7 435086 AW975243 Hs. 122596 ESTs 2. 0 2. 1 423191 D61506 Hs. 8417 hypothetical protein DKFZp761M0423 2. 0 2. 1 411562 AL050201 Hs. 70769 hypothetical protein DKFZp586E1923 2. 0 2. 8 431645 AF078849 Hs. 266483 dynein light chain-A 2. 0 2. 5 429834 A1929645 Hs. 225936 synapsin 1 2. 0 3. 6 439607 BE540565 Hs. 159460 ESTs 2. 0 17. 5 408033 AW138045 Hs. 242256 ESTs 2. 0 4. 0 430317 AB020645 Hs. 239189 glutaminase 2. 0 2. 7 419631 AW188117 Hs. 303154 popeyeprotein3 2. 0 2. 6 432660 A1288430 Hs. 64004 ESTs 2. 0 2. 3 454048 H05626 Hs. 6921 ESTs 2. 0 15. 9 426917 AA913814 Hs. 172854 DKFZP586B0923 protein 2. 0 3. 1

423246 AL119114 Hs. 77196 spectnn. alpha, non-erythrocytic 1 (alp 2. 0 2. 9 415989 A1267700 Hs. 317584 ESTs 2. 0 4. 8 420276 AA290938 Hs. 190561 ESTs, HighlysimilartoSORL_HUMANSORTI 2. 0 5. 1 424983 A1742434 Hs. 169911 ESTs 2. 0 15. 9 446296 AA985662 Hs. 63131 Homo sapiens cDNA FLJ13155 fis, clone NT 2. 0 2. 7 450006 A1241555 Hs. 60171 ESTs 2. 0 3. 5 TABLE 278 : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408274 104999 : R17315Z43964M053547 412100 1277224_1 AW892731 H08502Z45826 412112 1277883 1 BE180342 BE180347 AW901900 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE180228 AW901897 BE180224 AW901898 BE180223 BE180219 BE180346 BE180343 BE180418 BE180225 BE180221 BE180341 AW901894 BE180217 BE180227AW901891 BE180345 AW893614 AW893615 H85799 H83501 BE180220 413153 1350849_1 N94205 BE067565 BE067556 413510 1374377_1 F13044 T77009 BE145525 BE145493 414828 1495631 AA156651AA156622R14472 418948 180308_1 Al217097 AW886090W38035 W38792 M232835 AW936043 419558 185904 1 AW953679 AW953680 AA244436 H82527 AA361046 AA244483 H82526 421249 20064991 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204333_1 AW966652 AW966653 AA294989 M385977 429995 311738_1 M463571 Al277645AL118763 430212 314437-1 AA469153 A1718503 AA469225 432122 341756 1 AA526514 AW973343 AA554293 433449 366532 1 AW772282 AA592974 434138 380572 1 AA625804 AW418787 AW074833 AI675642 AI393368 437483 43756_1 AL390174 AW898817 439780 47673 1 AL109688 R23665 R26578 452502 919733 1 A1904296 BE007223 R30687 455517 1321782 AW984068AW984072AW984077 456407 184986 1 AW96861 AA243209 AA281411 TABLE 27C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22-Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 400979 8072554 Plus 160842-161028 401213 9858408 Plus 98243-98380, 98489-98619 401421 7452889 Minus 142291-142461 403092 8954241 Plus 174720-175016, 175104-175406, 175508-175813 404648 9796894 Minus 115334-116020 404793 7232206 Minus 61087-61590 404835 6970743 Plus 85462-85684, 88139-88287, 90338-91018, 94827-94990 405326 4375975 Plus 10633-10709, 30805-30893, 3807&38253, 55112-55327, 5771&57818, 6669G66841 405385 6552772 Plus 48332-48454 405793 1405887 Minus 89197-89453 405911 6758795 Plus 101008-101643 405977 8247789 Minus 135548-136177 TABLE 28A : About 139 genes up-regulated in glioma compared to normal adult tissues Table 28A lists about 139 genes up-regulated in glioma compared to normal adult tissues. In order to identify new genes that are associated with glioma, a non-redundant set of 6614 genes that have been previously identified were removed from the starting collection of 59680 probesets on the Affymetrix/Eos-HuO3 GeneChip array. Genes associated with glioma were selected from the remaining 53005 probesets such that the ratio of'average'glioma to'average'normal adult tissues was greater than or equal to 2. 5, and the'average' glioma value was greater than or equal to 50 units (this selects for the most abundant of the up-regulated genes). The'average'glioma level was set to the 94th percentile value amongst variou glioblastoma, astrocytoma, and oligodendroglioma specimens : the'average'normal adutt tissue level was set to the 85th percentile value amongst various non- malignant organs and tissues and other non-malignant brain tissues, In order to remove gene-specific background levels of non-specific hybridization, the 15th percenGle value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title ProL Doms : Predicted Protein Domains R1 : glioma vs normal adult tissues Pkey ExAccn UniGene ID Unigene Tiüe Protein Domains R1 443902 W28470 Hs. 12600 N-ethylmaleimide-sensitive factor a 4. 0 441476 R44566 Hs. 173134 ESTs 4. 0 446048 A1272364 Hs. 182081 KIAA1811 protein 3. 8 407061 X97748 gb : H. sapiens PTX3 gene promotor reg 3. 7 414323 NM_014759 Hs. 334688 KIAA0273 gene product fn3 ; TM ; 3. 6 439769 AA448828 Hs. 30596 HomosapiensmRNAfulllengthinser lactamase_B, Rhomboid. TPR 3. 6 429319 AL023754 Hs. 199068 similar to calcium/calmodulin depen pkinase : TM ; SS 3. 6 443412 W84893 Hs. 9305 angiotensin receptor-like 1 3. 5 425533 T47802 Hs. 9305 angiotensin receptor-like 1 3 5

408610 AW026692 Hs. 285050 ESTs ion_trans, K tetra, Kv2chan 3. 4 450678 AL109703 Hs. 25314 Homo sapiens mRNA full length inser 3. 4 419171 Nom002846 Hs. 89655 protein tyrosine phosphatase, recep Y-phosphatase, ART ; TM ; SS 3. 4 445875 AF070524 Hs. 13410 Homo sapiens clone 24453 mRNA seque 3. 4 412581 AA224244 Hs. 182704 ESTs, Moderately similar to alterna 3. 3 424911 AA984364 Hs. 7913 ESTs 3. 3 452753 AA028049 Hs. 277728 SEC14 (S. cerevisiae)-like 2 CRAL_TRIO 3. 3 436648 R18656 Hs. 352385 ESTs pkinase, pkinase_C, PMP22_C 3. 2 452130 AW248349 Hs. 28088 SGC32445 protein TB2DP1HVA22 ; TM ; SS 3. 2 448848 AF131851 Hs. 22241 hypothetical protein 3. 2 426470 AA528794 Hs. 128644 ESTs 3. 2 419344 U94905 Hs. 277445 diacylglycerol kinase, zeta (104kD) ank, DAGKa, DAGKc. DAGPE-bi 3. 2 439783 Al125760 Hs. 24835 hypothetical protein FU14594 ig, LRR, LRRNT, LRRCT ; TM ; S 3. 2 411358 R47479 Hs. 94761 KIAA1691 protein TM ; SS 3. 2 409433 AA074382 Hs. 135255 ADAMTS14 3. 2 456940 H46986 Hs. 31861 ESTs 3. 1 423744 D26158 Hs. 1701 ELAV (embryonic lethal, abnormal vi mn, Gene66 ; 3. 1 432227 U28389 Hs. 274122 erythrocyte membrane protein band 4 VHP ; TM ; 3. 1 449181 X96783 Hs. 23179 synaptotagmin V C2 ; TM : SS 3. 1 422274 NM 015564 Hs. 114169 KIAA0416protein LRRLRRNT, LRRCT ; TM ; SS 3. 1 424607 NM 016848 Hs. 151123 neuronal Shc PID, SH2 ; 3. 1 416898 BE219510 Hs. 234074 HomosapiensmRNA ; cDNADKFZp761G02 EGF, Rhabd qlycop ; TM ; SS= 3. 1 438162 NM 014618 Hs. 6090 deleted in bladder cancer chromosom TM ; SS 3. 1 439892 AL043463 Hs. 6755 RaP2 interacting protein 8 RUN ; SS 3. 1 445330 R52656 Hs. 21691 ESTs 7Un 1 3. 0 451766 NM_001406 Hs. 26988 ephnn-B3 Ephrin ; TM ; SS 3. 0 444457-Al204146 Hs. 92556 ESTs Fork_head 3. 0 458247 R14439 Hs. 209194 ESTs 3. 0 424616 U72671 Hs. 151250 intercellular adhesion molecule 5, ig, lCAM_N ; TM ; SS 3. 0 408971 R38990 Hs. 13485 ESTs 3. 0 423940 NM 012429 Hs. 277728 SEC14 (S. cerevisiae)-like 2 CRAL_TRIO ; TM ; 3. 0 458124 AW005548 Hs. 124590 ESTs 3. 0 410491 AA465131 Hs. 64001 Homo sapiens clone 25218 mRNA seque 3. 0 444808 H20019 Hs. 286084 ESTs ank, ras, PH, ArfGap, HC03_co 3. 0 437696 Z83844 Hs. 5790 hypothetical protein dJ37E16. 5 Hydrolase ; TM ; 2. 9 424016 AW163729 Hs. 6140 hypothetica) protein MGC15730 ig ; SS 2. 9 421680 AL031186 Hs. 289106 Human DNA sequence from clone CTA-9 Collagen ; TM ; SS 2. 9 418055 R18516 Hs. 351299 ESTs, Weakly similar to 138022 hypo ZZ, ZZ 2. 9 444819 A1697836 Hs. 148433 ESTs 2. 9 420524 AB010575 Hs. 98547 amiioride-sensitive cation channe) ASC ; TM ; 2. 9 416237 H30684 Hs. 159863 ESTs 2. 9 432270 AK001008 Hs. 274233 Homo sapiens cDNA FW10146 fis, clo 2. 9 405569 NM031481' : Homo sapiens solute carr mito_carrTM ; SS 2. 9 428950 BE311879 Hs. 194673 phosphoproteinennchedinatrocyt DED ; TM ; 2. 9 426128 NM 001471 Hs. 167017 gamma-aminobutyncacid (GABA) B re 7tm_3, sushi, ANF_receptor, Z9 447758 H17302 Hs. 93967 ESTs, Weakly similar to NBHUC8 deco LRRLRRNT, LRRCT ; TM ; SS 2. 9 445331 H04489 Hs. 12520 Homo sapiens clone 23568, 23621, 23 PC_rep 2. 9 431010 BE251246 Hs. 248214 complexin 1 TM ; 2. 9 433065 N62902 Hs. 343660 HomosapiensPACcloneRP4-651K2fr ; SS 2. 9 426845 AB025186 Hs. 172740 microtubule-associated protein, RP/EB1, CH ; TM ; 2. 9 454360 L78207 Hs. 54470 ATP-bindingcaseLe, sub-familyC ABC tran, ABC_membrane, PRK 2. 9 438859 Api559626 Hs. 93522 HomosapiensmRNAforKIM1647prot bZIP, K-box, 7tm 2, EGF, cadh 2. 9 410515 F12086 Hs. 4257 ESTs PID, SH2, PID, SH2 2. 8 434022 R18374 Hs. 117956 ESTs hommone_rec, zf-C4 2. 8 428960 AF052224 Hs. 194684 bassoon (presynaptic cytomatrix pro Caria_C4, RPH3A_effector ; T 2. 8 426290 AB007918 Hs. 169182 KIAA0449 protein WD40 ; TM ; 2. 8 417287 Api831678 Hs. 285714 KIAA1599 protein C2 ; TM ; 2. 8 422575 AK000546 Hs. 118552 hypotheGcalproteinFW20539 PTR2 ; TM ; SS 2. 8 417941 A1056049 Hs. 96297 ESTs Band41. ERM 2. 8 452707 A1093823 Hs. 45070 ESTs 2. 8 424873 AB018294 Hs. 153610 KIAA0751 gene product C2, PDZ ; TM ; 2. 8 408209 NM 004454 Hs. 43697 ets variant gene 5 (ets-related mol Ets ; TM ; 2. 8 415935 H09663 Hs. 106490 ESTs PID 2. 8 437999 AW905038 Hs. 90242 ESTs ion iwans 2. 8 428248 Al126772 Hs. 40479 ESTs 2. 8 414001 AI610347 Hs. 103812 ESTs, ModeratelysimilartoALU1_HU Gelsolin, VHP, p450 2. 8 406634 AA386235 Hs. 74576 GDP dissociation inhibitor 1 GDI ; TM ; 2. 8 453439 A1572438 Hs. 32976 guanine nucleoGde binding protein G-gamma : TM ; 2. 8 433320 D60647 Hs. 250879 ESTs, Highly similar to CTXN RAT CO mm 2. 8 420888 AB006713 Hs. 100058 dihydropyrimidinase-like 4 Dihydroorotase ; TM ; 2. 7 440001 A1740721 Hs. 128292 ESTs 2. 7 417622 AW298163 Hs. 82318 WAS protein family, member 3 WH2 ; TM ; 2. 7 438626 A1198059 Hs. 26370 ESTs 2. 7 404439 ENSP00000067222-: Mitochondrial 28S OLF ; SS 2. 7 448375 NM 004644 Hs. 21022 adaptor-related protein complex 3. Adaptin_N ; TM : 2. 7 420989 AB002372 Hs. 323833 syntaphilin TM-2. 7 419651 NM 007023 Hs. 91971 cAMP-regulated guanine nucleotide e cNMP_binding, DEP, RasGEF, R 2. 7 414562 AW955734 Hs. 112195 ESTs, Weakly similar to 2108402A ca 2. 7 410865 T16342 Hs. 66727 ESTs, Weakly similar to T31613 hypo IRK 2. 7 421146 A1082215 Hs. 97993 ESTs, ModeratelysimilartoSERP11 2. 7 419087 A1671245 Hs. 24835 hypothetical protein FLJ14594 ig, LRR, LRRNT, LRRCT ; TM ; S 2. 7 421499 A1271438 Hs. 236131 homeodomain-interacbng protein kin pkinase, Peptidase_M1 ; TM 2. 7 425014 Al251449 Hs. 171939 ESTs PID, PDZ 2. 7

448655 AL035289 Hs. 21708 hypothetical protein from clone 248 TM ; SS 2. 7 424410 W79027 Hs. 271762 ESTs 2. 7 447117 A1362798 Hs. 40183 ESTs 2. 7 447478 BE618843 Hs. 28144 fibronecUn type 3 and SPRY domain-fn3, SPRY ; TM ; 2. 7 437645 R20728 Hs. 21164 ESTs 2. 7 433698 H24201 Hs. 247423 adducin 2 (beta) Aidoiasen : TM : 2. 7 419701 AA248999 Hs. 7913 ESTs 2. 7 410510 AW294625 Hs. 64064 potassium voltage-gated channel, su cNMP binding, ion trans, PA 2. 7 452869 AB014534 Hs. 30898 KIAA0634 protein fn3 ; SS 2. 7 428045 T15465 Hs. 182231 thyrotropin-releasing hormone : SS 2. 7 425218 NM014909 Hs. 155182 KIAA1036 protein TM ; 2. 7 425558 AF040723 Hs. 158300 hunUngtin-assrJciated protein 1 (ne TM ; 2. 6 440789 AB007857 Hs. 7416 KIAA0397 gene product TBC, RUN : TM ; 2. 6 418423 NM 014732 Hs. 301658 KIAA0513 gene product TM ; 2. 6 450400 A1694722 Hs. 279744 ESTs pectin-c 2. 6 413566 AW604451 Hs. 285814 sprouty (Drosophila) homolog 4 SH2, SH3 ; TM ; SS 2. 6 443759 BE390832 Hs. 134729 FXYDdomån-containingiontranspor ATPlG1_PLM MAT8 ; TM ; SS 2. 6 425069 AA687465 Hs. 298184 potassium voltage-gated channel, sh a) doket. red 2. 6 429291 Al933057 Hs. 349189 mannosyl (alpha-1, 3->glycoprotein 2. 6 424798 AW016523 Hs. 182850 ESTs 2. 6 447455 H38335 Hs. 6750 Homo sapiens mRNA for FU00058 prot TM ; SS 2. 6 417212 AW952823 Hs. 351547 NS1-binding protein E2_N, E2_C, DNA mis_repair, 2. 6 432265 BE382679 Hs. 285753 SCG10 like-protein Stathmin ; TM ; SS 2. 6 417005 C21115 Hs. 26612 ESTs, Moderately similar to S23650 2. 6 421091 W22821 Hs. 351612 nbosoma ! protein L26 TM ; 2. 6 445472 AB006631 Hs. 12784 Homo sapiens mRNA for KIAA0293 gene homeobox, CUT ; TM ; 2. 6 431967 AJ243653 Hs. 373498 organic cation transporter sugar_tTM ; SS 2. 6 439151 AW135066 Hs. 283110 carbonicanhydraeX carb_anhydrae ; TM ; SS 2. 6 424134 AF070637 Hs. 140950 hypothetical protein DUF176 ; SS 2. 6 430213 AW993446 Hs. 235445 hypothetical protein FW21313 GRAM ; TM ; 2. 6 445954 AA148926 Hs. 27836 hypothetical protein FU22362 fn3 : TM : 2. 6 445084 H38914 Hs. 250848 hypothetical protein FLJ14761 TM ; SS 2. 6 446236 NM_006293 Hs. 301 TYR03 protein tyrosine kinase fi3, ig, pkinase ; TM ; 2. 6 433706 AW947250 Hs. 283645 ESTs PH, RhoGAP 2. 6 423606 AB011094 Hs. 129892 KIAA0522 protein PH, bZIP, lO, Sec7 ; TM ; 2. 5 438915 AA280174 Hs. 285681 Williams-Beuren syndrome chromosome 2. 5 448923 AL034562 Hs. 22584 prodynorphin Opiods_neuropep ; SS 2. 5 408115 AB033107 Hs. 42796 KIAA1281 protein 2. 5 446772 AW294404 Hs. 144515 Homo sapiens cDNA FLJ 11672 fis, clo 2. 5 427989 H85525 Hs. 40479 gb : yv88hO6. ri Scares melanocyte 2Nb TM ; SS 2. 5 435833 BE259178 Hs. 41641 Bruno (Drosophila) 4ike 4, RNA bin rrm ; TM ; 2. 5 423797 BE259364 Hs. 132898 fatty acid desaturae 1 heme_1, FA_desaturase ; TM 25 448277 BE622827 Hs. 99486 hypothetical protein FU13044 mito carr ; TM ; SS 2. 5 417298 AW665639 Hs. 37958 ESTs 2. 5 415577 AF257770 Hs. 20930 poly (rC)-binding protein 4 KH-domain ; TM ; 2. 5 420742 U79251 Hs. 99902 opioid-binding protein/cell adhesio ig ; TM ; SS 2. 5 419109 BE169157 Hs. 172717 ESTs pkinase. LRRCT, ig, LRR, LRRN 2. 5 TABLE 28C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et al."refers to the publication entitled'The DNA sequence of human chromosome 22-Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 405569 6006906 Plus 99719-99873 404439 7139680 Plus 55316-55585 TABLE 29A : ABOUT 362 GENES UP-REGULATED IN GLIOMA COMPARED TO NON-MALIGNANT ADULT BRAIN TISSUE Table 29A lists about 362 genes up-regulated in glioma compared to non-malignant adult brain tissue. These were selected as for Table 28A, except that the ratio of'average'glioma to'average'normal brain was greater than or equal to 3. 0, the'average'glioma level was set to the 99th percentile value amongst various glioma specimens, the'average'normal adult tissue) level was set to the 90th percentile value amongst various non-malignant adult brain specimens, the'average* glioma value was greater than or equal to 50 units. Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene fiUe Protein Domains : Predicted Protein Domains R1 : glioma vs non-malignant adult brain tissue Pkey ExAccn Unigene ID Unigene Tttle Protein Domains R1 414477 U41635 Hs. 76228 amplified in osteosarcoma pkinase, LRR, TM ; SS 11. 2 407241 M34516 gb : Human omega light chain protein TM : 10. 9 408972 AL050100 Hs. 49378 DKFZP586D0919 protein TM ; 7. 0 417512 X76534 Hs. 82226 glycoprolein (transmembrane) nmb PKD ; TM ; SS 6. 9 414001 A1610347 Hs. 103812 ESTs, ModeratelysimilartoALU1_HU Gelsolin. VHP, p450 6. 3 428847 A1954833 Hs. 98881 ESTs 6. 2 407061 X97748 gb : H. sapiens PTX3 gene promotor reg 5. 4 440020 A1480204 Hs. 177131 ESTs 5. 4 408832 AW085690 Hs. 63428 ESTs, Weakly similar to Z195_HUMAN 5 3 406837 R70292 Hs. 156110 immunoglobulin kappa constant 5. 2 407607 NM_001887 Hs. 37135 crystallin, beta B1 crystall ; TM ; 5. 1

435013 H91923 Hs. 110024 NM 020142 : HomosapiensNADH : ubiquin 5. 1 424916 AW867440 Hs. 23096 ESTs mm 5. 1 409659 AW970843 Hs. 55682 eukaryotic translation initiation f ; SS 5. 1 432576 AW157424 Hs. 165954 ESTs, Weakly similar to 138022 hypo rrm 5. 1 406621 X57809 Hs. 181125 immunoglobulin lambda oxus ig, HSP70, Ppx-GppA ; TM ; SS 5. 1 430418 R98852 Hs. 36029 heart and neural crest derivatives HLH 5. 1 441633 AW958544 Hs. 112242 nommalmucosaofesophagusspecrfic TM ; SS 5. 0 429707 W76631 Hs. 211819 maixmetailoproteinase23B ig, Peptidase_M1O ; TM ; SS= 5. 0 438915 AA280174 Hs. 285681 Wlliams-Beunensyndromechromosome 50 441321 H17182 Hs. 7771 B-cell associated protein Band_7 ; TM ; 5. 0 406848 Api264844 Hs. 275865 ribosoma'proteinS18 Rbosomal_S13 ; 4, 9 423505 AF064090 Hs. 129708 tumor necrosis factor (ligand) supe TNF ; TM ; SS 4. 8 433848 AF095719 Hs. 93764 carboxypeptidaseA4 ZncarbOpept. PropepM14 : T 4. 8 431882 NM 001426 Hs. 271977 engrailedhomolog 1 homeobox ; TM ; 4. 8 446295 Api355029 Hs. 101660 ESTs, Weakly similar to T1417 atax LIM 4. 8 409170 W91994 Hs. 16145 ESTs rrm 4. 8 421155 H87879 Hs. 102267 lysyl oxidase Lysyl_oxidase, Aldose_epim 4. 7 409202 AA236881 Hs. 51043 hexosaminidase B (beta polypepUde) Gtyco_hydro_20, Giyco_hydr 4. 7 412115 AK001763 Hs. 73239 hypothetical protein FU10901 ; SS 4. 7 450463 AW952018 Hs. 201398 Gproteincoupledreceptorinteract Clq, Collagen ; TM ; SS 4. 7 445960 A1268399 Hs. 140489 ESTs, WeaklysimilartoLIN1_HUMAN zf-C2H2, bZIP 4. 7 406807 AA057605 Hs. 180920 ribosoma'proteinS9 Rbosomal_S4XS48RNAint 4. 6 409190 AU076536 Hs. 50984 sarcoma amplified sequence transmembrane4 ; TM ; SS 4. 6 401699 Target Exon TM ; 4. 6 408901 AK001330 Hs. 48855 hypotheGcalproteinFFJ10468 TM ; 4. 6 441669 R78195 Hs. 29692 Homo sapiens cDNA FLJ11436 fis, clo 4. 6 406868 AA505445 Hs. 300697 immunoglobulin heavy constant gamma ig ; TM ; 4. 6 406699 L06505 Hs. 182979 ribosome protein L12 Ribosoma_L11 ; TM ; 4. 6 406663 U24683 immunoglobulin heavy constant mu ; SS 4. 6 427714 AF119850 Hs. 2186 eukaryoUctranslaGonelongaGonf COX8, SHMT, MIF, GST_C, EF1G_ 4. 6 407260 L09095 gb : Homo sapiens mRNA fragment 4. 5 406803 H42321 Hs. 163593 ribosome protein L18a Ribosomal_L18ae ; TM ; 4. 5 430397 Al924533 Hs. 105607 bicarbonate transporter related pro HC03_cotransp ; TM ; 4. 5 414044 BE614194 Hs. 75721 profilin 1 profilin ; TM ; 4. 5 424238 AA337401 Hs. 137635 ESTs TM ; SS 4. 5 421532 AW138207 Hs. 146170 hypothetical protein FW22969 Armadillo_seg, HEAT ; TM ; S 4. 4 421241 X91817 Hs. 102866 transketoiase-iiket transketoiase. transketpy 4. 4 436398 H87136 Hs. 5174 ribosome proteinS17 Ribosomal_S17e, PolyA pol ; 4. 4 428479 Y00272 Hs. 334562 cell division cycle 2, G1 to S and pkinase, ICEplO, ICE_p20 ; T 4. 4 446921 AB012113 Hs. 16530 small inducible cytokine subfamily IL8 ; SS 4. 3 433271 BE621697 Hs. 14317 nucleolarproteinfamilyA, member ; 43 406964 M21305 FGENES predicted novel secreted pro 4. 3 432191 AA043193 Hs. 273186 hypothetical protein, clone Teletho ABC1 ; TM ; 4. 3 420890 AA434058 Hs. 100071 6-phosphogluconolactonae Glucosamine_iso ; TM ; 4. 3 413053 AW963263 Hs. 65377 ESTs, Moderately similar to KIAA139 TM ; 4. 3 406687 M31126 Hs. 352054 matrix metalloproteinase 11 (strome hemopexin, Peptidase M10 ; T 4. 2 425157 NM006227 Hs. 283007 phospholipidtransferprolein LBP_BPI_CETP, LBP BPI_CETP 4. 2 426386 AA748850 Hs. 125830 bladder cancer overexpressed protei 4. 2 446490 AK000706 Hs. 15125 hypothetical protein FLJ20699 TM ; 4. 2 431750 AA514986 Hs. 283705 ESTs cpn60_TCP1 4. 2 428327 AW206236 Hs. 28773 ESTs cystatin, Coprogen_oxidas, 4. 2 417342 W40277 Hs. 81994 glycophorin C (Gerbich blood group) TM ; 4. 1 433688 AA628467 Hs. 112572 Homo sapiens cDNA FU14130 fis, clo 4. 1 433170 AB037816 Hs. 8982 KIAA1395 TM ; 4. 1 423084 AU076474 Hs. 123178 translocaeofinnermitochondnal mm 4. 1 407926 AW956382 Hs. 59771 ESTs TYA ; SS 4. 1 445636 AW105401 Hs. 350068 ribosome protein L29 4. 1 418689 A1360883 Hs. 375584 hypothetical protein FLJ11029 filament, GTP EFTU. EFG C, G 4. 1 450690 AA296696 Hs. 333418 FXYD domain-containing ion transpor ATP1G1_PLM_MAT8 ; TM ; SS 4. 1 419092 J05581 Hs. 89603 mucin 1, transmembrane SEA ; TM ; SS 4. 0 447813 A1394345 Hs. 238513 hypothetical protein MGC5442 ubiquitin ; TM ; SS 4. 0 436419 A1948626 Hs. 171356 ESTs AT hook, ATHILA 4. 0 458147 AW752597 gb : L3-CT0214-t61299-045-B06CT0214 PMM 4. 0 443402 U77846 Hs. 356316 elastin (supravalvular aortic steno PDZLIM, pkinase 4. 0 433435 BE545277 Hs. 340959 Ts translation elongation factor, m EFTS. UBA ; 4. 0 413595 AW235215 Hs. 16145 ESTs rrm 4. 0 412607 Z33642 Hs. 74115 immunoglobulin superfamily, member ig : TM ; SS 4. 0 419913 AW270040 Hs. 34455 ESTs EPH Ibd, fn3, pkinase, 4. 0 415209 F00183 Hs. 172004 GGn 4. 0 439310 AF086120 Hs. 102793 ESTs casein_kappa, pkinase, ig, n 3. 9 421777 BE562088 Hs. 108196 HSPC037 protein TM ; 3. 9 409485 S80990 Hs. 252136 ficolin (collagen/fibrinogen domain Collagen, fibrinogen_C ; TM= 3. 9 402241 Target Exon p450 ; TM : SS 3. 9 432716 A1762964 Hs. 205180 ESTs LRRUPAR LY6 ; TM ; 3. 9 418140 BE613836 Hs. 83551 microfibhiiar-associated protein 2 TM ; SS 3. 9 434214 AF119871 Hs. 155860 hypothetical protein PR02268 ; SS 3. 9 406855 AA902829 gb : ok72eO6. sl NCl-CGAP-GC4 Homo sap 3. 9 421567 AJ272137 Hs. 198265 matnxmelalloproteinase25 hemopexin, PepGdase M10 ; T 3. 9 403364 Target Exon SH2, Y-phosphatase 3. 9 412339 BE151267 Hs. 314466 ESTs tubuiin 3. 8 423007 AA320134 Hs. 196029 Homo sapiens mRNA for KIAA1657 prot TIMP 3. 8 427600 AW630918 Hs. 179774 proteasome (prosome, macropain) act PA28_alpha, PA28 beta ; 3. 8 405201 Target Exon mito_can, SH2, SH3, Alpha a 3. 8

436906 H95990 Hs. 181244 majorhistocompatibilitycomplex, c ig, MHC_I ; TM : SS 3. 8 407319 Api743332 Hs. 257729 ESTs. ModeratelysimilartoALU7 HU rrm, Lipoprotein_2 3. 8 400290 H18836 Hs. 31608 hypotheGcal protein FLJ20041 Cys_knot 3. 8 430240 BE303038 Hs. 236547 Homo sapiens, clone IMAGE : 2905978. HEATP8S ; TM ; 3. 8 442487 AF191019 Hs. 8361 hypotheGcal protein, estradiol-ind LRR, LRRNT : TM ; SS 3. 8 408135 AA317248 Hs. 42957 methyltransferase-like 1 Methyltransf 4 ; TM ; 3. 8 419942 U25138 Hs. 93841 potassium large conductance calcium CaKB ; TM ; SS 3. 8 410584 AB011112 Hs. 64742 KIAA0540 protein 3. 8 440676 NM 004987 Hs. 112378 LIM and senescent cell antigen4ike LIM ; SS 3. 8 406874 AW161706 Hs. 180842 ribosomal protein L13 Ribosomal Ll3e ; SS 3. 7 429249 X81479 Hs. 2375 egf-like module containing, mucin-I 7tm_2, EGF, GPS, SJocus_gly 3. 7 430799 C19035 Hs. 164259 ESTs FKBP, TPR 3. 7 453099 H62087 Hs. 31659 thyroid hormone receptor-associated WD40 ; TM ; 3. 7 421794 X86096 Hs. 108371 E2FtranscripGonfætor4, p107/p1 E2F_TDP, KOW, Ribosoma'L14 3. 7 444795 Ail93356 Hs. 160316 ESTs Tropomyosin, ACOX 3. 7 443834 Ai741510 Hs. 173548 ESTs CUB, MAM, F5_F8_bpe_C 3. 7 429731 AK001592 Hs. 212172 beta-carotene 15, 15'-dioxygenase RPE65 ; SS 3. 7 426433 L38969 Hs. 169875 thrombospondin 3 TSPN, tsp_3, EGF, toxin ; TM 3. 7 426395 BE151985 Hs. 355669 hypothetical protein FLJ23316 pkinase 3. 7 406704 M21665 Hs. 929 myosin, heavy polypepGde 7, candia myosin_head, lQMyosin_tå 3. 7 447860 AF193807 Hs. 131835 Rhesusbloodgroup, Bglyooprotein Ammonium_transp, FecCD ; TM= 3. 7 430281 A1878842 Hs. 237924 CGI-69protein mito can, homeobox ; TM ; S 3. 7 448360 AL117560 Hs. 306352 HomosapiensmRNA ; cDNADKFZpS66P23 3. 7 446057 A1420227 Hs. 366053 Trp-p8 transient receptor potential 3. 7 432078 BE314877 Hs. 24553 hypothefical protein FU12541 simil TM ; SS 3. 7 406854 AA613705 Hs. 252259 dbosomal protein S3 KH-domain, Ribosomai_S3_C ; 3. 7 422532 AL008726 Hs. 118126 protecUveproteinforbetagalæto serine_cabpeptGalP_UDP_ 3. 7 428171 AA489323 Hs. 182825 ribosome protein L35 Ribosoma_L29 ; 3. 6 442285 W28729 Hs. 356072 uncharactenzed hypothalamus protei 3. 6 411281 BE392792 Hs. 4786 Homo sapiens cDNA : FLJ22849 fis, cl cadherin 3. 6 457657 AW411509 Hs. 352567 hypothetica ! protein PR02121 UQcon ; TM ; 3. 6 414624 BE389320 Hs. 23628 3 beta-hydroxy-delta SC27-steroid 3. 6 451564 AU076698 Hs. 132760 hypotheGcalproteinMGCf5729 sugar tr, Condensaton, TM= 3. 6 445411 AL137255 Hs. 12646 hypothetcalproteinFW22693 hommõneJec, zf-CCCH, TM ; 3. 6 400785 C11000861 : gil9938016lreflNP_064687. TM ; SS 3. 6 413343 BE392026 Hs. 334346 hypothelical protein MGC13045 TM ; 3. 6 427380 NM_005534 Hs. 177559 interferon gamma receptor 2 (interf fn3 ; TM ; SS 3. 6 427818 AW511222 Hs. 193765 ESTs 3. 6 449957 D31365 Hs. 24220 hypotheucal protein TM ; 3. 6 451529 A1917901 Hs. 208641 ESTs acon 3. 6 446528 AU076640 Hs. 15243 nucleolarprotein 1 (120kD) Noll_Nop2_Sun ; TM ; 3. 6 431659 AA031875 Hs. 266940 t-complex-associated-tesGs-express Tctex-1 ; TM ; 3. 6 433350 BE563152 Hs. 10362 Homo sapiens cDNA : FU20944 fis, cl zf-C3HC4, SPRY 3. 6 412896 AW804157 Hs. 375570 major histocompabbility complex, c ig, MHC_II beta ; TM ; SS 3. 6 441748 R14439 Hs. 209194 ESTs 3. 6 406853 AA614553 Hs. 252259 hypothetical protein FU23059 KH-domain, Ribosomal_S3_C ; 3. 5 457464 AW972234 Hs. 126680 ESTs 3. 5 429619 AL120751 Hs. 211568 eukaryotietransiationinitiationf 3. 5 423309 BE006775 Hs. 126782 sushi-repeatprotein sushi, HYR ; SS 3. 5 438682 AA354489 Hs. 375594 EBP50-PDZ interactor of 64 kD 3. 5 453022 AA031499 Hs. 118489 ESTs Amino_oxidase 3. 5 434042 Al539941 Hs. 8254 Homo sapiens. Similar to tumor diff 3. 5 424867 Al024860 Hs. 153591 Not56 (D. melanogaster)-like protei TM ; SS 3. 5 417298 AW665639 Hs. 37958 ESTs 3. 5 403943 C5000355 : gil4503225lrehNP_000765. 1 3. 5 429497 AB028953 Hs. 204121 KIAA1030 protein fn3 ; TM : 3. 5 426613 U96132 Hs. 171280 hydroxyacyl-CoenzymeAdehydrogenas adh short ; TM ; SS 3. 5 428343 AL043021 Hs. 12705 ESTs WD40 ; SS 3. 5 456376 AA663904 Hs. 89862 TNFRSFlA-associated via death domai death ; TM ; 3. 5 400348 AJ251708 Hs. 352588 Target 3. 5 404854 Target Exon ; SS 3. 5 427930 AA417696 Hs. 372121 ESTs 3. 5 453143 AA382234 Hs. 356289 protein tyrosine phosphatase, recep serpin ; SS 3. 5 406806 AW088535 Hs. 350108 ribosomal protein, large, PO TM ; 3. 5 406793 AW264291 Hs. 5662 guanine nucleotide binding protein WD40 ; TM ; 3. 5 414525 C14904 Hs. 45184 Homo sapiens cDNA FW 12284 fis, clo 3. 5 419950 AK001645 Hs. 93871 hypothetical protein FU10783 Glyco hydro_47 ; TM ; SS 3. 5 404243 Nom-006778 : Homo sapiens ring finger zf-C3HC4, zf-B_box ; TM ; SS 3. 4 424611 NM001421 Hs. 151139 E74-like factor 4 (ets domain trans Ets ; SS 3. 4 432831 Api821702 Hs. 115959 ESTs, Weakly similar l0138022 hypo 3. 4 413943 AW294416 Hs. 144687 Homo sapiens CDNA FU 12981 fis, clo TM ; 3. 4 418558 AW082266 Hs. 86131 Fas (TNFRSF6)-associated via death death, DED ; SS 3. 4 408930 AA146721 Hs. 334686 hypothetical protein FU21588 CUE ; TM ; 3. 4 403246 Target Exon HMG box ; SS 3. 4 416330 AU077101 Hs. 79222 galactosidase, beta 1 Glyco_hydro_35 ; TM : SS 3. 4 404864 NM_025204': Homo sapiens hypothetica 3. 4 441384 AA447849 Hs. 288660 HomosapienscDNA : FLJ22182 fis, cl 7t 3 3. 4 430284 A1693534 Hs. 293196 ESTs 3. 4 433669 AL047879 Hs. 194251 ESTs, Weaklysimila toALU2_HUMAN RNA_pol_L, RNA_pol_L, RaGA 3. 4 456050 R79445 Hs. 76230 dbosomal protein S10 S10piectin ; TM ; 3. 4 422311 AF073515 Hs. 114948 cytokine receptor-like factor 1 fn3 ; TM ; 3. 4 408909 AW502034 Hs. 287379 ESTs, Weakly similar to T26022 hypo 3. 4 428028 U52112 Hs. 182018 interleukin-1 receptor-associated k death, pkinase ; TM ; 3. 4

424213 BE390125 Hs. 143187 hypothetical protein DEAD, helicase_C ; TM ; 3. 4 416432 BE391767 Hs. 79322 glutaminyl-tRNAsynthetase 3, 4 400233 Eos Control Ribosoma S9 ; 3. 4 403252 Target Exon TM ; SS 3. 4 409433 AA074382 Hs. 135255 ADAMTS14 3. 4 426053 U68105 Hs. 172182 poly (A)-binding protein, cytoplasmi mm, PABP ; TM ; 3. 4 448222 A1648587 Hs. 20725 Mov10 (Moloney leukemia virus 10, m TM ; 3. 4 432982 AA531058 Hs. 182248 truncated calcium binding protein OPR, ZZ ; TM ; 3. 4 453914 NM 000507 Hs. 574 fructose-1, 6-bisphosphatase 1 FBPase ; TM ; 3. 4 444626 AA320893 Hs. 117062 hypotheGcalproteinFW14497 pyr_redox ; TM ; SS 3. 4 427751 AF000152 Hs. 355816 conserved gene amplified in osteosa NIF ; TM : 3. 4 416971 R34657 Hs. 80658 uncoupling protein 2 (mitochondrial mito_carr ; TM ; 3. 4 428046 AW812795 Hs. 337534 ESTs, Moderately similar to 138022 ank 3. 4 456575 AW063659 Hs. 191649 ESTs Myosinlail 3. 4 407366 AF026942 Hs. 17518 gb : Homo sapiens cig33 mRNA, partial IBR 3. 4 414738 L24038 Hs. 77183 v-rafmurinesanoma3611viråonc pkinase, DAG_PE-bind, RBD ; T 3. 4 456356 M74715 Hs. 89560 iduronidase, alpha-L-Glyco_hydro_39 ; SS 3. 3 429668 AA626142 Hs. 179991 ESTs, Weakly similar to S28942 prot 3. 3 404913 NM024408' : Homo sapiens Notch (Dros EGF, ank. notch. metalthio, E 3. 3 426059 BE292842 Hs. 166120 interferonregulatoryfactor7 IRF ; SS 3. 3 451619 AA018854 Hs. 353196 glutathione peroxidase 3 (plasma) PH ; SS 3. 3 410225 AW608964 Hs. 12030 ESTs 3. 3 402534 Target Exon 3. 3 433750 H15448 Hs. 31330 HomosapienscloneHtO319 GLFV_dehydroxq, GLFV_dehydr 3. 3 421712 AK000140 Hs. 107139 hypothetical protein TM ; SS 3. 3 433333 A1016521 Hs. 71816 v-akt murine thymoma viral oncogene pkinae, PH, pkinae_C 3. 3 424915 R42755 Hs. 23096 ESTs rrm 3. 3 408494 AA554714 Hs. 187578 Homo sapiens CDNA FU 11639 fis, clo 3. 3 445084 H38914 Hs. 250848 hypothetical protein FU14761 TM ; SS 3. 3 446478 A) 950021 Hs. 370306 ESTs TM ; 3. 3 425274 BE281191 Hs. 155462 minichromosome maintenance deficien MCM ; TM ; 3. 3 456655 Ai376736 Hs. 111779 secreted protein, acidic, cysteine-kazat. SS 3. 3 438912 AF085843 gb : Homo sapiens full length insert 3. 3 428396 U70539 Hs. 184161 exostoses (multiple) 1 Exostosin ; TM ; SS 3. 3 437546 AW074836 Hs. 173984 T-box 1 T-box, WD40 ; TM ; 3. 3 410693 BE044206 gb : ho40cO8. x1 SoaresNFLTGBCS1 H C1q, Collagen, cystati 3. 3 414961 U27266 Hs. 927 myosin-binding protein H fn3, ig ; TM : 3. 3 422766 AA334108 Hs. 159572 heparan sulfate (glucosamine) 3-0-s 3. 3 426120 AA325243 Hs. 166887 copine I C2, rrm ; TM ; 3. 3 452383 T70900 Hs. 27189 ESTs zf-C2H2, PRK 3. 3 456799 AC004923 Hs. 135187 unc93 (C. elegans) homolog B TM ; 3. 3 409227 AA806165 Hs. 130323 Homo sapiens, clone (MAGE : 3960432, NA ; NA 3. 3 432659 AA281633 Hs. 278586 KIAA1108 protein TBC ; TM ; 3. 3 448997 AA130390 Hs. 25549 hypothetical protein FU20898 TM ; SS 3. 3 446990 A1354717 Hs. 223908 ESTs transmembrane4 3. 3 437259 Api377755 Hs. 120695 ESTs MHCIl_aipha, ig 3. 3 423461 AB020527 Hs. 128827 solulecarierfamily17 (sodiumph sugar tr ; TM, 33 421563 NM 006433 Hs. 105806 granulysin ; SS 3. 3 453804 AA300204 Hs. 35276 KIAA0852 protein TM ; 3. 3 428810 AF068236 Hs. 193788 nitricoxidesynthase2A (inducible NAD binding, Aavodoxin, FA 3. 3 453933 A1452933 Hs. 65377 ESTs EF TS, UBA, transmembr 3. 3 449267 A1638640 Hs. 220624 ESTs 3. 3 418165 R45959 Hs. 6637 ESTs mito_carr 3. 3 446673 NM_016361 Hs. 15871 LPAP tor lysophosphatidic acid phos acid_phosphat ; TM ; SS 3. 3 402475 ubiquitin specific protease 18 3. 2 404233. Target Exon HIT 3. 2 406655 M21533 Hs. 277477 major histocompatibility complex, c ig, MHC I ; TM ; SS 3. 2 414556 AW975063 Hs. 343443 ribosomal protein L36 Ribosomal_L36e : 3. 2 450191 AW137243 Hs. 248074 ESTs homeobox ; TM ; 3. 2 435906 Api686379 Hs. 110796 SARl pnotein af, raTM, 3. 2 412540 Ci8341 Hs. 73999 thyroidhormonereceptwinteractor SH3, FCH ; SS 3. 2 422562 Api962060 Hs. 118397 AE-bindingproteinl Zn-carbopep8F5-F8-qpe-c 3. 2 431051 AA491143 Hs. 283374 ESTs, WeaklysimilartoCA15_HUMAN TM ; 3. 2 407984 AW134708 Hs. 243569 ESTs 3. 2 441494 AW452344 Hs. 129977 ESTs 3. 2 423114 AU076497 Hs. 1614 cholinergic receptor, nicotinic, al Neur_chan_LBD, Neur chan_m 3. 2 419833 AA251131 Hs. 220697 ESTs WHEP-TRS, tRNA-synt_1b, non 3. 2 419036 T80967 Hs. 372603 gb : yd23f12. sl Soaresfetal liver sp 3. 2 431222 X56777 Hs. 273790 zonapellucida glycoprotein 3A (spe zona_pellucida ; TM ; SS 3. 2 453094 AA740928 Hs. 27356 ESTs 3. 2 426989 Ai815206 Hs. 367644 ESTs BAG, ubiquitin 3. 2 445033 AV652402 Hs. 72901 cyclin-dependent kinase inhibitor 2 ank ; 3. 2 446272 BE268912 Hs. 14601 hematopoietic cell-specific Lyn sub SH3, HS1 rep ; TM ; 3. 2 438930 AW843633 Hs. 343261 hypotheGcaproteinAL110115 HLH 3. 2 438183 BE263252 Hs. 6101 hypolheGcaiproleinMGC3178 thioreri ; TM ; 3. 2 421310 AW630087 Hs. 103315 UinucleoGderepeatcontainingt PHD 3. 2 409293 R02673 Hs. 110156 ESTs 3. 2 407115 AA084921 Hs. 76230 Hbosomat protein SIO S10-plecbn ; TM ; 3. 2 401174 Target Exon transmembrane4, EF TS, UBA 3. 2 400217 Eos Control ra ; SS 3. 2 408676 Api815189 Hs. 57475 sexcombonmidleXqhomolog1 3. 2 418245 AA088767 Hs. 83883 transmembrane. prostate androgen in TM ; SS 3. 2 403694 Target Exon UDPGT 3. 2

414265 BE410411 Hs. 75864 endoplamicneUculumglycopnztein 3. 2 451118 A1862096 Hs. 60640 ESTs EGF, vwc, TIL ; SS 3. 2 422624 BE616678 Hs. 76152 KDEL (Lys-Asp-Glu-Leu) endoplasmic ER_lumen recept 3. 2 437388 AL359586 Hs. 14478 HomosapiensmRNA ; cDNADKFZp762H18 3. 2 429150 AF120103 Hs. 197366 smoothened (Drosophila) homolog COXB, SHMT, MIF, GST_C, EFt_ 3. 2 430379 AF134149 Hs. 240395 potassium channel, subfamily K, mem ion-trans ; TM ; SS 3. 2 434956 BE266566 Hs. 4288 hypotheticalprotein DKFZp434K046 Cullin ; TM ; 3. 2 422166 W72424 Hs. 112405 SIOOcatdum-binding protein A9 (ca efhand, S 100. TM. 3. 2 452493 Api904031 Hs. 106826 KIAA1696 protein PHD. Myc-LZ. DC1. AThook. TM 3. 2 413100 BE065208 gb : RC1-BT0314-310300-01Sb09 BT0314 3. 2 420764 BE250676 Hs. 19928 hypothetical protein SP329 F-box ; TM ; 3. 2 421680 AL031186 Hs. 289106 Human DNA sequence from clone CTA-9 Collagen ; TM ; SS 3. 2 406738 AA587983 gb : nj30bO9. s1 NCI_CGAP_A1 Homosap TIM, Ribosomal SS ; TM ; SS= 3. 1 434288 AW189075 Hs. 116265 fibrillen3 EGF, granulin, TB, EB, TIL : TM 3. 1 438264 T86773 Hs. 6133 calpån 5 Calpainill, PepGdae_C2, 3. 1 436819 AA731746 Hs. 120232 ESTs mm 3. 1 459298 R86701 gb : ym86dO9. r1 Soares adult brain N2 TM ; 3. 1 452127 BE562126 Hs. 28081 eukaryotstranslaGoninitationf rrm, 7tm_1, SNF ; TM ; 3. 1 422305 AI928242 Hs. 293438 ESTs, Highly similar to AF1984881 3. 1 414393 AA146855 gb : zo41hl O. rl Strataqqene endothelia 31 423369 BE219099 Hs. 279513 ESTs 3. 1 429457 BE243065 Hs. 202955 hypotheticalprotein FU20507 Cys-protease-3C ; TM ; 3. 1 409124 AW292809 Hs. 50727 N-acetytglucosaminidase, alpha- (Sa TM ; SS 3. 1 429615 AF258627 Hs. 211562 ATP-binding cassette, sub-family A ABC_tran ; TM ; SS 3. 1 445519 AI635202 Hs. 170132 hypothetical protein FLJ22494 TM ; 3. 1 410007 AW950887 Hs. 57813 zinc ribbon domain containing, 1 TFIIS ; TM ; 3. 1 407228 M25079 Hs. 155376 hemoglobin, beta globin ; TM ; 3. 1 411573 A8029000 Hs. 70823. KIAA1077 protein Sulfatase ; TM ; 3. 1 406654 M90686 Hs. 73885 HLA-GhistocompaSbilityanúgen, c ig, MHC_l ; TM ; SS 3. 1 435072 AW592176 Hs. 116932 ESTs zf-RanBP, MDM2 3. 1 456642 AW451623 Hs. 109752 putative c-Myc-responsive ; SS 3. 1 445457 AF168793 Hs. 12743 camitine 0-octanoyltransferase Carn_acyltransf ; TM ; 3. 1 448389 AW188950 Hs. 345838 ESTs 20G-Fell Oxy, rrm, SH3. ras 3. 1 458248 BE407379 Hs. 108082 ESTs, Weakly similar to T31636 hypo Clq, Collagen ; TM ; SS 3. 1 451310 AW250651 Hs. 26213 Human DNA sequence from clone RP3-4 TM ; 3. 1 414688 Api750246 Hs. 76901 for protein disulfide isomerase-rel thiored ; SS 3. 1 428797 AA496205 Hs. 193700 Homo sapiens mRNA ; cDNA DKFZpS86103 LlM, Ran_BP1, GRIP, TPR, pro 3. 1 425067 BE223071 Hs. 169142 ESTs 3. 1 410639 BE269047 Hs. 65234 hypothetical protein FU20596 DEAD, helicase C, PRK, AIP3 ; 3. 1 413011 AW068115 Hs. 821 biglyean LRR, LRRNT ; SS 3. 1 421502 AF111856 Hs. 105039 solutecanierfamily34 (sodiumph Ribosoma_L20, Na_Pi cotra 3. 1 447164 AF026941 Hs. 17518 vipirin ; similartoinflmmatoryr MoaA_NiflB_PqqE ; TM : 3. 1 414907 X90725 Hs. 77597 polo (Drosophia)-like kinase Ribosomal L37ae, pkinase, P 3. 1 418613 AA744529 Hs. 86575 mitogen-acuvated protein kinase ki pkinase, CNH ; TM ; 3. 1 406734 A1565616 gb : to16h12. x1 NCl_CGAP_Ut2 Homo sap 3. 1 410188 AL096739 Hs. 107260 hypothetica) protein DKFZp586H0623 RicinB) ecfn. Gfycostra 3. 1 437959 A1472068 Hs. 375604 K1AA1856 protein elF5 eIF2B, W2 ; TM : 3. 1 406764 AA429825 Hs. 343443 nbosoma'prolein L36 Ribosomal_L36e ; 3. 1 406637 U14966 Hs. 180946 ribosomal protein L5 Ribosomal Ll8p ; 3. 1 451080 H41082 Hs. 271783 ESTs 3. 1 414875 H42679 Hs. 77522 major histocompatibility complex, c ig, MHC__alpha ; TM ; SS 3. 1 416365 U15131 Hs. 79265 suppression of tumorigenicity 5 DENN, dDENN, uDENN ; TM ; SS= 3. 1 400261 Eos Control ig, MHC II beta ; TM ; SS 3. 1 412270 AC005262 Hs. 73797 guaninenucleoGdebindingprotein G-a'pha, arf ; TM ; 3. 1 456843 BE301883 Hs. 152707 glioblastoma amplified sequence 3. 1 443071 AL080021 Hs. 8986 complement component 1, q subcompon Clq, Coliagen ; SS 3. 1 426196 BE272095 Hs. 167791 reliculocalbin 1, EF-hand calcium b efhand ; SS 3. 1 424010 AL080188 Hs. 137556 Homo sapiens mRNA ; cDNADKFZp434A13 cadherin ; TM ; SS 3. 1 439975 AW328081 Hs. 6817 inosine triphosphatase (nucleoside Hamip_like ; TM ; 3. 1 450761 R75930 Hs. 174838 Homo sapiens cDNA FLJ 14192 fis, clo 3. 1 418322 AA284166 Hs. 84113 cyclin-dependentkinase inhibitor 3 Yphosphatase, DSPc ; TM ; S 3. 1 432396 AW295956 Hs. 11900 hypotheUcaproteinFW14972 Xiink, zf-CCCH, G-patch, non 3. 1 407904 W44735 Hs. 107260 Homo sapiens cDNA : FLJ21278 fis, cl 3. 1 452500 AW373011 Hs. 54558 hypothetical protein FU22222 3. 1 432171 A1202503 Hs. 343661 ESTs, WeaklysimilartoALUB_HUMAN WD40 3. 1 416768 AA363733 Hs. 1032 regenerating islet-derived 1 alpha lecfin_ ; TM ; SS 3. 1 442492 AA528489 Hs. 234518 ribosomal protein L23 Ribosomal L14 ; 3. 0 421210 U80016 Hs. 102598 mucosal vascular addressin cell adh TM ; SS 3. 0 439429 AF150286 gb : Au) 50286 Human mRNA from cd34 st RA, Band 7, MBOAT 3. 0 447463 AW378685 Hs. 18625 MitochondnáAcyhCoAThioesterae Acyl-CoA hydro ; TM ; 3. 0 448352 AA337951 Hs. 20991 SET domain, bifurcated 1 AhpC-TSA, SET, MBD ; TM ; SS= 3. 0 428291 AA534009 Hs. 183487 interferon stimulated gene (20kD) 3. 0 445669 Al570830 Hs. 174870 ESTs 3. 0 452862 AW378065 Hs. 8687 ADAMTS2 (adisintegnn-likeandme Pep_M12B_propep, tsp_1, Rep 3. 0 430069 Api219293 Hs. 293660 Homo sapiens, clone IMAGE : 3535476, SPRY, zf-B_box, zf-C3HC4 ; TM 3. 0 451028 AA021258 Hs. 123073 ESTs 3. 0 446021 BE389213 Hs. 286 ribosomal protein L4 Ribosomal_L4 ; TM : 3. 0 434652 AF148713 Hs. 125830 bladdercanceroverexpressedprotei WD40, DUF6, 3. 0 425829 AL133079 Hs. 134126 crystallin, gamma S Ctystafi ; TM ; 3. 0 424909 S78187 Hs. 153752 cell division cycle 25B Rhodanese ; SS 3. 0 423579 NM 004121 Hs. 1675 gamma-glutamyltransferase-like acG Gglu_transpephTM ; SS 3. 0 444652 BE513613 Hs. 11538 æGnreiáedprotein213complex, WD40 ; TM ; 3. 0 441283 AA927670 Hs. 131704 ESTs CUB, MAM, F5_FB_Wpe_C 30

437415 AL137400 Hs. 306456 pre-mRNA processing factor 18 Band_41, hormone2, Prpl8 ; TM 3. 0 444542 Al161293 Hs. 280380 aminopeptidase NAD binding, flavodoxin, FA 3. 0 442426 A1373062 Hs. 332938 hypothetical protein MGC5370 zf-RanBP, MDM2 3. 0 447910 AL137679 Hs. 20000 Homo sapiens mRNA ; cDNA DKFZp434D24 Exonuclease ; SS 3. 0 426858 Nom-004182 Hs. 172791 ubiquitously-expressed transcript DUF232 ; SS 3. 0 445417 AK001058 Hs. 12680 adisintegnn-likeandmetalloprote tsp_1, Reprolysin, Pep M12B 3. 0 430482 AF131810 Hs. 241545 hypothetical protein TM ; SS 3. 0 427661 AA410292 Hs. 104761 ESTs wnt 3. 0 451876 T63141 gb : yb99al2sl Straagene lung (9372 SH3 3. 0 453862 AL137493 Hs. 35945 Homo sapiens mRNA ; cDNA DKFZp434B12 ig ; TM ; 3. 0 452965 Api904779 Hs. 247525 Human DNA sequence from clone RP11-C2, PHD, RPH3A effector, zf- 3. 0 441455 AJ271671 Hs. 7854 zindiron regulated transporter-lik Zip ; TM ; SS 3. 0 452600 A1910842 Hs. 103381 ESTs Exoendophos 3. 0 450775 AA902384 Hs. 73853 bone morphogenetic protein 2 TGFb_propeptide, TGF-beta, 3. 0 417634 W27202 Hs. 82327 glutathione synthetase GSH_synthase ; TM ; 3. 0 415152 W22644 Hs. 278712 Homo sapiens CDNA FUl 1074 fis, clo 3. 0 410093 AW589558 Hs. 299883 ESTs, Weakly similar to KIAA0970 pr 3. 0 412404 AW075995 Hs. 86228 TRIAD3 protein 3. 0 443466 BE243123 Hs. 321045 IKK-related kinae epsilon ; inducib pkinase, RIOI ; TM ; 3. 0 TABLE 298 : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 458147 1030220_t AW848781 AW848490 AW849062 AW752597 AW752699 406855 0 0 AA902829 400233 11259_1 BC004324 NM_001020BC007977 M60854BM050628BG829809BE385504 BG744451 81826914 BE440007 81260656 BE395117 BE389334 BE255792 Bai194169 B1668218 Bai194376 BG716213 BG714408BE392513 AV722219AW328077 BM424171 Bl828267AW958606 BG831252 BE392943 BE394033 Bai858915 B1668334 BE621019 BG706995 BE791985 BF967484 B1193635 BG761859 BM466537 BG747165 BG827488 A1133550 BM011511 Bl227282BG489212 BG478388 BE727789 Bl160880 BG831707 BG324692 BM470427 Bl083889 BG831605BG754114 BG420536 BF308210 BE384213 BG832271 BG828032 BG481641 BF205675 BE899041 BE271558 81193807 81159866 B473786 BG397178 81194428 81117210 BG768326 BG759507 BF975645 BF343657 BM020598 BG831082 BG829943 BG829501 BF306557 BE562511 BM050145 BM017978 B1193934 Bl160764 Bai160371 BG754991 BF973348 BF663234 BF032537 BE388168 BM009051 B1192794 BG831002 BG830459 BG764737 BG761808 BG481705 BG104314 BM464565 81261500 BG831857 BG831684 BG829852 BG765030 BG760419 BG760268 BG749762 BG480900 BG419627 BG248771 BF975542 BM042233 Bi 161149 BG831302 BG830033 BG829626 BM050064 Bl193014 Bl161360 BG822729 BG110091 BG106500 81258369 BG831982 BM458301 BM019513 Bl161350 Bl114178 BG481969 BG474870 BF974048 BF971122 BE741405 BE395269 BG832027 BG831469 BG490895 BM413638 BG943529 BG831012 BG829471 BG686284 BG337575 BG336551 BF206677 Bl258301 Bl 160946 BG105893 BF183072 BM459542 B1193881 BG832043 BG831323 B1194545 Bl160968 BG755930 BG706018 BE743865 BM465145 BG831227 BG774290 BF683451 BE907161 BM045391 BIt94396 Bl 161269 BG747091 BG546643 BF984863 Bl 160206 Bl226402 Bl226336 AW328236 BG339458 BF972634 BE909808 81160988 B1160251 BG828764 BG826860 BG758360 BF568228 B1818282 Bai457127 BG831491 BG759864 Al830010 BF568381 BE907238 Bol161172 Bit 16773 BG827153 BG825088 BG335419 BG109404AI929068 BE906354 BE408564 BM045000 BG339617 BG282794 BG335767 BE907263 BF568921 BG829961 BG479305 BG260397 A1922228 BE301975 AW516055 BG480919 BG480626 AW196817 BG336261 BE906157 BE395717 BE391427 BN192954 BG829757 BG476379 BE301536 BE394727 BE257695 BE905344 A1433577 BE894416 BE886992 BE409223 BF034756 BE904077 BG830886 BE909153 BE907998 BE395767 Ai871751 BE744523 BN192663 BG831669 Ai000225 BE743836 BE272515 AA628078 BM463802 BE393375 BE393033 AW1701 87 BE730961 BE395410 BE744572 BE392297 BE391448 BE390780 BE388821 BE258477 BE905970 BE901567 BE898833 BE880326 BF726889 BE910504 BE390753 BE390131 AA650542 BE744156 BE394125 BE742207 BE395265 BE392942 BE894336 BE378222 BE906926 BE904650 BE393704 BE620999 BE515162 BE378753 BE272370 BE907458 BE612801 BE392484 BE907636 BE907353 BE910491 BE909796 BE905331 AW248173 AI683576 BE908826 BE620180 BF037570 BE908312 BE615015 BE256977 BE746875 BE394133 BE391478 BE910068 BE907185 BE742109 AA995746 BE561195 BE908825 BE906472 BE906509 BE906017 BE910442 BE514657 B1261969 BE741707 BE392216 BM042793 BF570283 Bai262119 BE395707 BE378298 AW327827 BE394422 BF569178 BE263240 AI700512 BG830290 BF569308 BF569156 B1194587 BE390831 BG745096 Al681675 BE395674 AA136372 BE279892 AA442822 BE384898 AA313519 AI878866 AA305904 F33366 BE394852 F29153 F33618 AI133637 AA300009 F34063 F29455 AU099691 Al905085 Al906656 M343249 BE388691 AW404280 AA379888 F29022 BF089981 F31013 F24305 438912 4071 1 AF085843 R70623 R70523 410693 1054267_1 BE044205 AW797320 BE161 676 AW797356 AW797352 413100 1490226i BE065224 BE065168 BE065313 BE065208 406738 0 0 AA587983 459298 90831_2 AL157655 BF802216 R86701 BF802224 R84600 BF356151 BG982935 414393 15833_3 AL532972 B1092731 Al765546 M393801 Al129669 Al393538 AW519008 Api432598 AW295856 Al650941 A1470541 AL550388 AA146856 Al074762 BE895187 AA393867 B1052082 406734 0_0 Al555616AI190141 400261 231101 BC006097 X03066 NM002120 M26040 AW469119 AW469127 A1299772 AW518149 A1144456 AW628070 Al629032 Al358810 A1880433 Al440472 AI357070 AI865365 AW014799 Al767973 AW518041 AA909398 AW768606 439429 452694_1 AF150286AV739062M835857 451876 2328579_1 T63141AI821021BF370092BF370127BF370060T62998 TABLE 29C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers."Dunham, et a. refers to the publication entitled The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 401699 3176654 Minus 33285-34084 402241 7690131 Minus 125073-125206. 130996-131125 403364 8571785 Plus 120351-120465 405201 7230116 Plus 36934-37314 400785 8131682 Plus 43113-43967 403943 7711864 Plus 100742-100904, 101322-101503 404854 7143420 Plus 14260-14537

404243 5672609 Plus 74695-75123 403246 7637831 Minus 143547-143654, 143741-143900 404864 5263010 Plus 94495-94661, 9505595195, 9739&97506, 9760 403252 7677983 Plus 102214-102692 404913 7341740 Plus 97717-97976 402534 9801061 Plus 58989-59457 402475 7547191 Plus 65363-65725 404233 8218045 Minus 84791-85123 401174 9438414 Minus 132847-133917 403694 7107765 Plus 142925143080, 165505166186, 16748&16763 TABLE 30A : ABOUT 282 GENES UP-REGULATED IN GLIOMA COMPARED TO NON-MALIGNANT ADULT BRAIN TISSUES THAT ARE LIKELY TO ENCODE EXTRACELLULAR OR CELL-SURFACE PROTEINS Table 30A lists about 282 genes up-regulated in glioma compared to non-malignant adult brain tissues that are likely to encode extracellular or cell-surface proteins. These were selected as for Table 28A, except that the ratio of'average'glioma to'average'normal adult Gssues was greater than or equal to 4. 0, the'average'glioma level was set to the 99th percentage value amongst various glioma specimens, the'average'normal adult brain Gssue level was set to the 75th percentage value amongst various non-malignant brain tissues, the'average'gl'roma value was greater than or equal to 50 units (this selects for the most abundant of the up-regulated genes), and the predicted protein contained a structural domain that is indicative of extracellular localization (e. g. ig, fn3, efg, 7tm domains, signal sequences, transmembrane domains). Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene fige Protein Domains : Predicted Protein Domains RI : glioma vs. non-malignant adult brain tissues likely to encode extracellular or cell-surface proteins Pkey Accession UniGene ID Unigene Title Protein Domains R1 406868 AA505445 Hs. 300697 immunoglobulin heavy constant gamma ig ; TM ; 37. 6 407241 M34516 gb : Human omega light chain protein TM ; 22. 7 414477 U41635 Hs. 76228 amplified in osteosarcoma pkinase, LRR ; TM ; SS 22. 7 417512 X76534 Hs. 82226 glycoprotein (transmembrane) nmb PKD ; TM ; SS 15. 4 406803 H42321 Hs. 163593 ribosomalproteinL18a Ribosomal L18ae ; TM ; 14. 2 429707 W76631 Hs. 211819 matrix metalloproteinase 23B ig, Peptidase_M10 ; TM ; SS= 12. 8 419092 J05581 Hs. 89603 mucin 1, transmembrane SEA ; TM ; SS 12. 8 414738 L24038 Hs. 77183 v-raf murine sarcoma 3611 viral onc pkinase, DAG_PE-bind, RBD ; T 12. 4 441384 AA447849 Hs. 288660 HomosapienscDNA FW22182ñs, cl 7tm_3, none 11. 6 406621 X57809 Hs. 181125 immunoglobulin lambda ocus ig, HSP70, Ppx-GppA ; TM ; SS 11. 0 410584 AB011112 Hs. 64742 KIAA0540 protein none 11. 0 426395 BE151985 Hs. 355669 hypothetical protein FLJ23316 pkinase. none 10. 7 425184 BE278288 Hs. 155048 Lutheran blood group (Auberger b an ig ; TM ; SS 10. 7 430379 AF134149 Hs. 240395 potassium channel, subfamily K, mem ion_trans ; TM ; SS 10. 3 408972 AL050100 Hs. 49378 DKFZP586D0919 protein TM ; 9. 9 446921 AB012113 Hs. 16530 small inducible cytokine subfamily IL8 ; SS 9. 9 452862 AW378065 Hs. 8687 ADAMTS2 (adisintegrin-likeandme Pep_M12B_propep, tsp_1, Rep 9. 7 418101 AL047476 Hs. 296310 gap junction protein, alpha 4, 37kD connexin ; TM ; SS 8. 5 400290 H18836 Hs. 31608 hypothetical protein FLJ20041 Cysknot 8. 4 401699 Target Exon TM ; 8. 1 423309 BE006775 Hs. 126782 sushi-repeat protein sushi, HYRSS 8. 1 427600 AW630918 Hs. 179774 proteasome (prosome, macropain) act PA28_alpha, PA28_beta ; 7. 9 436906 H95990 Hs. 181244 major histocompatibility complex, c ig, MHCj ; TM ; SS 7. 8 425335 BE394327 Hs. 296267 follistaGn-like 1 efhand, kazal, arf, ras, 7tm_ 7. 7 413011 AW068115 Hs. 821 biglycan LRR, LRRNT ; SS 7. 7 446295 A1355029 Hs. 101660 ESTs, Weakly similar to T14171 atax LIM 7. 7 436398 H87136 Hs. 5174 ribosomal protein S17 Rbosomal_S17e, PolyA_pol ; 7. 6 435013 H91923 Hs. 110024 Nom 020142 : Homo sapiens NADH : ubiquin none 7. 4 431809 AI623488 Hs. 333488 Homo sapiens, clone IMAGE : 3603998, TM ; SS 7. 4 424608 X80695 Hs. 151134 oxidase (cytochrome c) assembly 14 60KD_IMP ; TM ; 7. 3 438560 AA481690 Hs. 300697 immunoglobulin heavy constant gamma ig 7. 3 429297 X82494 Hs. 198862 fibulin 2 EGF, ANATO. TIL, spidertoxin 7. 3 450463 AW952018 Hs. 201398 G protein coupled receptor interact Clq, Collagen ; TM ; SS 7. 2 417342 W40277 Hs. 81994 glycophorinC (Gerbichbloodgroup) TM, 7. 2 414688 A1750246 Hs. 76901 for protein disulfide isomerase-rel thiored ; SS 7. 2 414044 BE614194 Hs. 75721 profilin 1 profilin ; TM ; 7. 1 404864 NM025204' : Homo sapiens hypothetica 7. 1 452127 BE562126 Hs. 28081 eukaryotic translation initiation f mm, 7bm_1, SNF ; TM ; 7. 0 412115 AK001763 Hs. 73239 hypotheGcalproteinFW10901 ; SS 7. 0 409826 AW501112 Hs. 353013 hypothetical protein FLJ23412 none 6. 9 434343 AW956705 Hs. 3804 DKFZP564C1940 protein Idl recept_a ; TM ; 6. 9 427714 AF119850 Hs. 2186 eukaryoticbranslaGonelongationf COX8, SHMT, MIF, GST_C, EF1G_ 6. 9 437259 Api377755 Hs. 120695 ESTs MHC_ll_alpha, ig, none 6. 9 429212 NM001504 Hs. 198252 G protein-coupled receptor 9 7tm1 ; TM ; 6. 8 448988 Y09763 Hs. 22785 gamma-aminobutyricacid (GABA) Are Neur chan LBD, Neur chan m 6. 8 423505 AF064090 Hs. 129708 tumor necrosis factor (ligand) supe TNF ; TM ; SS 6. 8 413053 AW963263 Hs. 65377 ESTs, Moderately similar to KIAA139 TM ; 6. 7 430542 Api557486 Hs. 119122 ribosomalproteinL13a Ribosoma'_L13, LACT, ad, ra 6. 7 435906 Al686379 Hs. 110796 SAR1 pnotein ad, ras ; TM ; 6. 6 429307 AU076592 Hs. 198951 jun B proto-oncogene bZIP ; TM ; 6. 4 437388 AL359586 Hs. 14478 HomosapiensmRNA ; cDNADKFZp762H18 none 6. 4 415714 NM 002290 Hs. 78672 laminin, alpha4 laminin-EGFlaminin-GTro 6. 3 406733 AA976565 Hs. 297753 vimentin filament, bZIP, Apolipoprot 6. 3 411296 BE207307 Hs. 10114 growthsuppressorl 20G-Fell_Oxy ; TM ; SS 6. 3 441321 H17182 Hs. 7771 B-cell associated protein Band_7 ; TM ; 6. 3 444637 T19101 Hs. 11494 fibulin 5 EGF, TIL ; SS 6. 3

413731 BE243845 Hs. 75511 connecUveUssuegrowthfætor Cys_knot, tsp_1, vwc, 1GFBP ; 6. 2 422901 R81936 Hs. 374568 ribosome protein L44 sushi, none 6. 2 430397 A1924533 Hs. 105607 bicarbonate transporter related pro HC03_cotransp ; TM ; 6. 1 429630 M85289 Hs. 211573 heparan sulfate proteoglycan 2 (per EGF, ig, laminin_B, laminin_ 6. 1 434867 AF159442 Hs. 103382 phospholipid scramblase 3 SAPA, Scramblase ; TM ; SS 6. 1 431449 M55994 Hs. 256278 tumornecrosisfætorreceptorsupe TNFR_c6 ; TM ; SS 6. 1 440676 NM_004987 Hs. 112378 LlMandsenesnfllanUgen-like LIM ; SS 6. 0 424658 NM 002406 Hs. 151513 mannosyl (alpha-1, 3--glycoprotein GNT-I, Glycos transf_2 ; TM= 5. 9 439310 AF086120 Hs. 102793 ESTs casein kappa, pkinase, ig, n 5. 9 410169 Api373741 Hs. 59384 hypothetical protein MGC3047 ig ; TM ; 5. 8 423007 AA320134 Hs. 196029 HomosapiensmRNAforKIM1657prot TlMP, none 5. 8 414265 BE410411 Hs. 75864 endoplasmic reticutum glycoprotein none 5. 8 427715 BE245274 Hs. 180428 KIAA1181 protein TM ; 5. 8 409220 BE243323 Hs. 51233 tumor necrosis factor receptor supe TNFR c6, death, Lipoprotein 5. 8 450690 AA296696 Hs. 333418 FXYDdomain-containingiontranspor ATP1G1 PLM_MAT8 ; TM ; SS 5. 8 433848 AF095719 Hs. 93764 carboxypepEdase A4 Zn_carbOpept, Propep_M14 ; T 5. 7 446404 AA019961 Hs. 26216 LOC50627 none 5. 7 441641 AI650417 Hs. 247068 ESTs, ModeratelysimilartoAW8_HU Plerin_4a, fibnnogen_C, Co 5. 7 418875 W19971 Hs. 233459 ESTs Xiink, none 5. 7 424748 AA346257 Hs. 134933 ESTs none 5. 7 439737 A1751438 Hs. 41271 Homosapienscollagen, qpeVlil, a Clq, Collagen, none 5. 7 448950 AF288687 Hs. 9275 CGI-152 protein E1-E2 ATPase, Hydrolase ; TM 5. 6 406654 M90686 Hs. 73885 HLA-G histocompatibility antigen, c ig, MHC_l ; TM ; SS 5. 6 423084 AU076474 Hs. 123178 transiocase of inner mitochondria) rnn 5. 6 402241 Target Exon p450 ; TM ; SS 5. 6 425157 NM_006227 Hs. 283007 phospholipid transfer protein LBP_BPI_CETP, LBP_BPI_CETP 5. 6 428343 AL043021 Hs. 12705 ESTs WD40 ; SS 5. 6 447990 BE048821 Hs. 20144 small inducible cytokine subfamily IL8 ; SS 5. 6 412607 Z33642 Hs. 74115 immunogtobutinsuperfamiiy. member ig : TM ; SS 5. 5 447625 AW505364 Hs. 19074 LATS (large tumor suppressor. Droso pkinase, pkinase_C, UBA, Pol 5. 5 408056 AA312329 Hs. 42331 ephrin-A4 Ephrin ; TM ; SS 5. 5 445960 A1268399 Hs. 140489 ESTs, Weakly similar to LINt HUMAN zf-C2H2, bZIP, none 5. 5 406874 AW161706 Hs. 180842 ribosome protein L13 Ribosomal Ll3e ; SS 5. 4 418558 AW082266 Hs. 86131 Fas (TNFRSF6)-associated via death death, DED ; SS 5. 4 414638 W03516 Hs. 76698 stress-associated endoplasmic re6c TM ; SS 5. 4 409190 AU076536 Hs. 50984 sarcoma amplified sequence transmembrane4 ; TM ; SS 5. 4 429150 AF120103 Hs. 197366 smoothened (Drosophila) homolog COX8, SHMT, MIF, GST_C, EF1G_ 5. 3 453099 H62087 Hs. 31659 thyroid hormone receptor-associated WD40 ; TM ; 5. 3 414443 AU077268 Hs. 76144 piateiet-derived growth factor rece ig. pkinase. TM ; 5. 3 441283 AA927670 Hs. 131704 ESTs CUB, MAM, F5_F8_type_C, none 5, 3 414249 Api797994 Hs. 279929 gp25L2 protein Sulfotransfer, EMP24 GP25L 5. 3 451154 AA015879 Hs. 33536 ESTs TIMP, none 5. 2 406655 M21533 Hs. 277477 major histocompatibility complex, c ig, MHC_l ; TM ; SS 5. 2 406656 M16714 Hs. 89643 majorhistocompa6bilitycomplex, c transketolase. transketpy 5. 2 449224 AW995911 Hs. 299883 hypothetical protein FLJ23399 fn3 ; TM ; 5. 2 422562 A1962060 Hs. 118397 AE-binding protein 1 Zn carbOpept, FS_FB type C 5. 2 436127 W94824 Hs. 11565 RlKENcDNA2010100012gene TM ; SS 5. 2 428327 AW206236 Hs. 28773 ESTs cystatin, Coprogen_oxidas, 5. 2 427080 AW068287 Hs. 301175 ras-related C3 botulinum toxin subs ras ; TM ; 5. 2 414624 BE389320 Hs. 23628 3 beta-hydroxy-delta 5-C27-steroid none 5. 2 430281 Al878842 Hs. 237924 CGI-69 protein mito carr, homeobox ; TM ; S 5. 2 426433 L38969 Hs. 169875 thrombospondin 3 TSPN, tsp_3, EGF, toxin ; TM 5. 1 432716 Api762964 Hs. 205180 ESTs LRR, UPAR LY6 ; TM ; 5. 1 451564 AU076698 Hs. 132760 hypothetical protein MGC15729 sugar_tr, Condensation. TM= 5. 1 409340 BE174629 Hs. 321130 hypotheGcalproteinMGC2771 aa pemieaes, pyridoxal_de 5. 1 432680 T47364 Hs. 278613 interferon, alpha-inducible protein TM ; SS 5. 1 404913 NM024408' : Homo sapiens Notch (Dros EGF, ank, notch, meta ! thio. E 5. 1 409485 S80990 Hs. 252136 ficolin (coliagentfibrinogen domain Collagen, fibdnogen-C ; TM= 5. 1 432078 8E314877 Hs. 24553 hypolheGcaiproteinFW12541simil TM ; SS 5. 1 406687 M31126 Hs. 352054 matrix metalloproteinase 11 (strome hemopexin, Peptidase M10 ; T 5. 1 423712 W46802 Hs. 81988 disabled (Drosophila) homolog 2 (mi PID, MACPF, Idl_recept_a, ts 5. 0 441595 AW206035 Hs. 356457 ESTs sugars. none 5. 0 450435 Api695975 Hs. 201805 ESTs EGF, laminin B, laminin EGF 5. 0 443177 BE268461 Hs. 202 benzodiazapine receptor (peripheral TspO MBR ; TM ; SS 5. 0 433435 BE545277 Hs. 340959 Ts translation elongation factor, m EF TS, UBA ; 5. 0 426386 AA748850 Hs. 125830 bladder cancer overexpressed protei none 5. 0 419913 AW270040 Hs. 34455 ESTs EPH Ibd, fn3, pkinase, 5. 0 446696 AF279265 Hs. 298476 solute canter family 26, member 6 Sulfate_transp, STAS, xanu 5. 0 448997 AA130390 Hs. 25549 hypothetical protein FLJ20898 TM ; SS 5. 0 413891 BE271020 Hs. 355753 tumor suppressor deleted in oral ca none 5. 0 453143 AA382234 Hs. 356289 protein tyrosine phosphatase, recep serpin ; SS 5. 0 448249 AW855331 Hs. 337124 ESTs carb anhydrase, UCH-1, UCH- 5. 0 412819 T25829 Hs. 24048 FK506 binding protein precursor FKBP ; TM ; SS 5. 0 426059 BE292842 Hs. 166120 interferon regulatory factor 7 IRF ; SS 5. 0 432295 BE091049 Hs. 343665 ribosomåproteinS15a Ribosomal_S8, RNae_PH, KH-sO 412540 C18341 Hs. 73999 thyroid hormone receptor interactor SH3, FCH ; SS 5. 0 414465 AW270645 Hs. 76194 nbosoma ! protein S5 Ribosoma ! S7 : 5. 0 456655 AI376736 Hs. 111779 secreted protein, acidic, cysteine-kazal ; SS 5. 0 421794 X86096 Hs. 108371 E2FtranssnpSonfætor4, p107/p1 E2F TDP, KOW, Ribosoma L14 4. 9 444824 AA843575 Hs. 12056 asialoglycoproteinreceptor1 lecGñ c, TnopomyosinTM 4. 9 438278 BE409248 Hs. 57988 hypothetical protein FW22357 simil TFIIS, RNA_POL_M_15KD, UPFo 4. 9 418140 BE613836 Hs. 83551 microfibrilla-asociated protein 2 TM ; SS 4. 9 429457 BE243065 Hs. 202955 hypothetical protein FU20507 Cys-protease3C ; TM ; 4. 9

449475 A1348027 Hs. 108557 hypothetical protein PP1057 transmembrane4 ; TM ; SS 4. 9 425274 BE281191 Hs. 155462 minichromosome maintenance deficien MCM ; TM ; 4. 9 442110 AF113008 Hs. 8102 ribosomal protein S20 Ribosomal_S10 ; TM ; 4. 9 415209 F00183 Hs. 172004 t ! tin none 4. 9 451849 A1199261 Hs. 27191 hypothetical protein from clone 247 TM ; 4. 9 421567 AJ272137 Hs. 198265 matrixmetaloproteinae25 hemopexin, Pepüdae_M10, T 4. 9 427380 NM_005534 Hs. 177559 interferon gamma receptor 2 (interf fn3 ; TM ; SS 4. 9 431303 AW241605 Hs. 253928 ESTs none 4. 9 432396 AW295956 Hs. 11900 hypothetical protein FU14972 Xlink, zf-CCCH, G-patch, non 4. 9 415021 R54409 Hs. 301693 Homo sapiens, clone IMAGE : 3638994, none 4. 8 430498 X02910 Hs. 241570 tumor necrosis factor (TNF superfam TNF ; TM ; SS 4. 8 449957 D31365 Hs. 24220 hypothetical protein TM ; 4. 8 419603 BE262579 Hs. 91566 PL6 protein OMPdecase ; TM ; SS 4. 8 427588 L25081 Hs. 179735 ras homolog gene family, member C ras, none 4. 8 421502 AF111856 Hs. 105039 solute carrier family 34 (sodium ph Ribosomal L20, Na_ coUa 4. 8 404854 Target Exon : SS 4. 7 411281 BE392792 Hs. 4766-HomosapienscDNA FW22849fis, cl cadhenn 4. 7 414045 NM_002951 Hs. 75722 ribophorin II gpdh, gpdh_C, pili assembly 4. 7 431830 Y16645 Hs. 271387 small inducible cytokine subfamily IL8 ; SS 4. 7 412896 AW804157 Hs. 375570 major histocompatibiiity complex, c ig. MHCJLbeta : TM ; SS 4. 7 429305 AF095727 Hs. 287832 myelin protein zero-like 1 ig, transmembrane4 ; TM ; SS 4. 7 451698 Y16187 Hs. 26880 endothelin converting enzyme-like 1 Peptidase M13 ; TM ; 4. 7 422687 AW068823 Hs. 119206 insulin-like growth factor binding zf-C2H2, ig, none 4. 7 444542 Ai161293 Hs. 280380 aminopepGdase NAD binding, flavodoxin, FA 4. 7 429833 NM 012079 Hs. 288627 diacylglycerol 0-acyltransferase (m ACAT ; TM ; 4. 7 456376 AA663904 Hs. 89862 TNFRSFlA-asociatedviadeaGhdomå deåh ; TM ; 4. 7 438568 R98865 Hs. 11135 major histocompatibility complex, c MHC_ll_alpha, ig, none 4. 7 456356 M74715 Hs. 89560 iduronidase, alpha L-Giyco_hydro_39 ; SS 4. 7 420486 AF036365 Hs. 98303 caveolin 3 Caveolin ; TM ; 4. 6 425123 AW205274 Hs. 154695 phosphomannomutase 2 PMM ; SS 4. 6 439512 AA418287 Hs. 58093 Homo sapiens, done IMAGE : 3163559, laminin_EGF ; TM ; 4. 6 418424 Y13622 Hs. 85087 latent transforming growth factor b EGF, TB, spidertoxin, granul 4. 6 433350 BE563152 Hs. 10362 Homo sapiens cDNA : FU20944 fis, cl zf-C3HC4, SPRY, none 4. 6 432659 AA281633 Hs. 278586 KIAA1108 protein TBC ; TM ; 4. 6 445417 AK001058 Hs. 12680 adisintegrin-likeandmetalloprote tsp_l, Reprolysin, Pep_M128 4. 6 437408 AL359598 Hs. 36606 Homo sapiens mRNA cDNADKFZp547B08 none 4. 6 427349 AA360154 Hs. 177415 Finkel-Biskis-Reillymurinesarcoma ubiquitin ; TM ; 4. 6 418918 X07871 Hs. 89476 CD2 antigen (p50), sheep red blood ig ; TM ; SS 4. 6 421310 AW630087 Hs. 103315 trinudeotiderepeatcontainingi PHD 4. 6 427969 NM 001963 Hs. 2230 epidermal growth factor (beta-uroga EGF, Mireceptb. EB ; TM ; 4. 6 447860 AF193807 Hs. 131835 Rhesus blood group, B glycoprotein Ammonium transp, FecCD ; TM= 4. 6 418916 BE392781 Hs. 89474 ADP-ribosylation factor 6 arf, ras ; TM ; 4. 6 425720 AA362394 Hs. 293984 hypothetical protein MGC13102 TM ; SS 4. 6 419942 U25138 Hs. 93841 potassium large conductance calcium CaKB ; TM ; SS 4. 6 403105 Target Exon ISK Channel ; TM ; SS 4. 6 418067 A1127958 Hs. 83393 cystaGn E/M cystatin ; SS 4. 6 427863 AF189712 Hs. 181002 MLLsepGn-likehusion GTP_CDC ; TM ; 4. 5 458147 AW752597 gb : lL3CT0214-161299-045-B06CT0214 PMM, none 4. 5 456799 AC004923 Hs. 135187 unc93 (C. elegans) homolog B. TM ; 4. 5 427136 AL117415 Hs. 173716 a disintegrin and metalloproteinase ig 4. 5 458766 AW183618 Hs. 55610 solute carrier family 30 (zinc tran Cation_efflux ; TM ; SS 4. 5 445033 AV652402 Hs. 72901 cyclin-dependent kinase inhibitor 2 ank ; 4. 5 441281 BE501247 Hs. 144084 ESTs Collagen, C4, none 4. 5 439720 AI935202 Hs. 31181 HomosapienscDNA : FU23230 fis, cl SDF, sugar_tr 4. 5 410184 AW503667 Hs. 59545 ringfingerprotein15 SPRY, zf-B box, zf-C3HC4 ; TM 4. 5 431760 NM 005317 Hs. 268531 granzymeM (lymphocytemet-ase 1) tlypsin ; TM ; SS 4. 5 446990 A1354717 Hs. 223908 ESTs transmembrane4 4. 5 407366 AF026942 Hs. 17518 gb : Homo sapiens cig33 mRNA, partiat IBR 4. 5 426156 BE244537 Hs. 167382 natriureGc pep6dereceptorA/guan ANF receptor, guanylate cy 4. 5 442941 AU076728 Hs. 8867 cysteine-rich, angiogenic inducer, Cys_knot, tsp_l. vwc, IGFBP ; 4. 5 451118 A1862096 Hs. 60640 ESTs EGF, vwc. TIL ; SS 4. 5 457657 AW411509 Hs. 352567 hypothetical protein PR02121 UQ con ; TM ; 4. 4 437016 AU076916 Hs. 5398 guanine monphosphate synthetase PHD, SET, zf-CXXC, EGF, ank, n 4. 4 429497 AB028953 Hs. 204121 KIAA1030 protein fn3 ; TM ; 4. 4 444090 S69115 Hs. 10306 naluralkillerceligroup7sequenc PMP22_Uaudin ; TM ; SS 4. 4 454005 AF039237 Hs. 288600 hypothetical protein MGC3123 TM ; SS 4. 4 412270 AC005262 Hs. 73797 guanine nucleotide binding protein Gatpha, arf ; TM ; 4. 4 406729 AA069711 gb : zmS2bil. s1 Strafagenefibroblast filameni, bZIP, Apolipoprot 4. 4 404610 Homo sapiens cDNA FW11027 fis, clo EGF, laminin_B, laminin_EGF 4. 4 422311 AF073515 Hs. 114948 cytokinerecepior-likefætor1 hn3 ; TM ; 4. 4 406973 M34996 Hs. 198253 majorhistocompaSbilibcomplex, c ig, MHC_ll_apha ; TM ; SS 4. 4 407196 D11747 Hs. 177415 Finkel-Biskis-Reillymurinesarcoma ERG4_ERG24, none 4. 4 404243 NM006778 : Homosapiensringfinger zf-C3HC4, zf-B box ; TM ; SS 4. 4 443834 Api741510 Hs. 173548 ESTs CUB. MAM. F5'F8typeC. none 4. 4 446057 A1420227 Hs. 366053 Trp-p8 transient receptor potential none 4. 4 413661 AA071146 Hs. 343354 ribosomalproleinL18 Ribosomal_L18e, L15 ; TM ; S 4. 4 414875 H42679 Hs. 77522 major histocompatibility complex, c ig, MHC_ll_åpha ; TM ; SS 4. 4 439730 AF035292 Hs. 6654 KIAA0657 protein fn3, ig ; 4. 3 406257 Target Exon 7tm_l, none 4. 3 434025 AF114264 Hs. 216381 Homo sapiens clone HH409 unknown mR ig ; TM ; 4. 3 414961 U27266 Hs. 927 myosin-binding protein H fui3, ig ; TM ; 4. 3 430265 L36033 Hs. 237356 stromal cell. derived factor 1 IL8 ; SS 4. 3 429249 X81479 Hs. 2375 egf-like module containing, mucin-I 7tm_2, EGF, GPS, S_bsus_gly 4. 3

433541 AW081538 Hs. 220324 hypothetical protein FU13052 NAD kinase ; TM : 4. 3 400575 NM022146 : HomosapiensneuropepUde 7bm_1 ; TM ; SS 4. 3 427661 AA410292 Hs. 104761 ESTs wnt, none 4. 3 452056 AW955065 Hs. 101150 Homo sapiens, clone IMAGE : 4054156, TM ; 4. 3 433669 AL047879 Hs. 194251 ESTs, WeaklysimilartoALU2 HUMAN RNA_pol_L, RNA_pol_L, RaGA 4. 3 422624 BE616678 Hs. 76152 KDEL (Lys-Asp-Giu-Leu) endoplamic ER_iumen_recept, none 43 421680 AL031186 Hs. 289106 Human DNA sequence from clone CTA-9 Collagen ; TM ; SS 4. 3 422766 AA334108 Hs. 159572 hepaansulfate (glucosamine) 3-s none 4. 3 437596 AA761490 Hs. 351250 ESTs, Moderately simila to S65657 pkinase, WD40 4. 3 419285 D31887 Hs. 89868 KIAA0062 protein Zip ; TM ; SS 4. 3 453082 H18835 Hs. 31608 hypothetical protein FW20041 ion trans ; TM ; SS 4. 2 410693 BE044206 gb : ho40cO8. x1 Soares_NFL_T_GBC_S1 H Clq, Collagen, cyst 4. 2 413100 BE065208 gb : RC1-BT0314-310300-015-b09BT0314 none 4. 2 432497 AA551104 ESTs, Moderately similar to ALUC_HU none 4. 2 423041 BE170842 Hs. 123059 chloride channel Kb CBS. voltage_CLC ; TM ; SS 4. 2 449799 Al143466 Hs. 125060 ESTs none 4. 2 438472 AW974907 Hs. 86228 TRIAD3 protein none 4. 2 432179 X75208 Hs. 2913 EphB3 EPH Ibd, fn3, pkinase, SAM ; T 4. 2 424488 AK000413 Hs. 149227 hypothetical protein FU20406 Xlink, z (-CCCH, G-patch ; TM= 4. 2 406809 AF000574 Hs. 22405 leukocyte immunoglobulin4ike recep ig, Gemini mov ; TM ; SS 4. 2 407586 Z37544 Hs. 37121 phospholipase C, beta 3 (phosphaüd C2, PI-PLC-Y, PI-PLC-X TM 4. 2 407228 M25079 Hs. 155376 hemoglobin, beta globin ; TM ; 4. 2 450900 H61005 Hs. 37902 ESTs none 4. 2 410188 AL096739 Hs. 107260 hypotheUcal protein DKFZpS86H0623 Ricin_B_lechn, Glycos_tra 4. 2 458248 BE407379 Hs. 108082 ESTs, Weakly similar to T31636 hypo Clq, Collagen ; TM ; SS 4. 2 403138 NM006056 : Homo sapiens G protein-co 71m_1, HECT ; TM ; SS 4. 2 432074 AA525248 Hs. 149723 ESTs Y-phosphatase, none 4. 2 438682 AA354489 Hs. 375594 EBP50-PDZ interactor of 64 kD none 4. 2 401908 C17000154 : gil12003980lgblMG43830. 1 TM ; SS 4. 2 451287 AK002158 Hs. 26194 likely homolog of mouse immunity-as TM ; 4. 2 407904 W44735 Hs. 107260 Homo sapiens cDNA : FU21278 fis, cl none 4. 1 403694 Target Exon UDPGT-4. 1 423461 AB020527 Hs. 128827 solutecanierfamily17 (sodiumph sugar_tTM ; 41 425603 U52219 Hs. 158329 G protein-coupled receptor SO 7 1 ; TM ; SS 4. 1 421485 AA243499 Hs. 104800 hypolheGcåproleinFLJl0134 TM ; SS 4. 1 414509 AW161311 Hs. 76294 CD63 antigen (melanoma 1 an6gen) transmembrane4 ; TM ; SS 4. 1 423313 NM 014269 Hs. 126838 adisintegrinandmetalloproteinase disintegnn, Reprolysin, Pe 4. 1 432171 Api202503 Hs. 343661 ESTs, Weakly similar to ALUB HUMAN WD40 4. 1 434652 AF148713 Hs. 125830 bladdercanceroverexpressed protei WD40, DUF6 ; 4. 1 429592 AB029041 Hs. 209646 KIAA1118 protein Troponin, Exo endohos. l 4. 1 432982 AA531058 Hs. 182248 truncated calcium binding protein OPR, Z ; TM ; 4. 1 424867 Al024860 Hs. 153591 Not56 (D. melanogaster)-like protei TM ; SS 4. 1 441455 AJ271671 Hs. 7854 zinc/iron regulated transporter-lik Zip ; TM ; SS 4. 1 400785 C11000861 : gil9938016lref ; Ni'_064687. TM ; SS 4. 1 447232 AW499834 Hs. 327 interleukin 10 receptor, alpha TM ; SS 4. 1 450785 AA852713 Hs. 108885 Homo sapiens, alpha-1 (VI) collagen vwa, Collagen ; TM ; SS 4. 1 424027 AW337575 Hs. 201591 ESTs 7tm_2, HRM, none 4. 1 435857 AF253468 Hs. 3736 delta-like 4 homolog (Drosophila) EGF, DSL, EB ; TM ; SS 4. 1 437118 AB037857 Hs. 300591 CD9 partner 1 none 4. 1 411410 R20693 Hs. 69954 laminin, gamma3 laminin_B, laminin_EGF, lam 4. 1 413902 AU076743 Hs. 75613 CD36 antigen (collagen type I recep E2F_TDP, CD36 ; SS 4. 1 428938 AC002425 Hs. 194660 ceroid-lipofuscinosis, neuronal 3, CLN3 ; TM ; SS 4. 1 453094 AA740928 Hs. 27356 ESTs none 4. 1 440811 BE384713 Hs. 74655 ESTs, Weakly similar to T34482 hypo hormone_rec, zf-C4, none 4. 0 407287 Ai678812 Hs. 345139 gb : tu59d08. xl NCl_CGAP_Ga4Homosa ra, cadhenn 4, 0 428028 U52112 Hs. 182018 intedeukin-1 receptor-associated k death, pkinase ; TM ; 4. 0 428469 BE549205 Hs. 184488 Botillin 2 none 4. 0 423114 AU076497 Hs. 1614 cholinergic receptor, nico6nic, al Neur_chan LBD, Neur_chan_m 4. 0 426858 NM 004182 Hs. 172791 ubiquitously-expressed transcript DUF232 ; SS 4. 0 444626 AA320893 Hs. 117062 hypotheticalprotein FLJ14497 pyr_redox ; TM ; SS 4. 0 TABLE 30B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 458147 1030220 1 AW848781 AW848490 AW849062 AW752597 AW752699 406729 0 0 AA069711 410693 1054267_1 BE044206 AW797320 BE161676 AW797356 AW797352 413100 1490226_1 BE065224 BE065168 BE065313 BE065208 432497 85271 AW874688R94134AA551104AA777322AN33094BE247143 TABLE 30C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication enGtied'The DNA sequence of human chromosome 22'Ounham, el al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 401699 3176654 Minus 33285-34084 404864 5263010 Plus 944994661, 9505595195, 97396-97506, 9760

402241 7690131 Minus 125073-125206, 130996-131125 404913 7341740 Plus 97717-97976 404854 7143420 Plus 14260-14537 403105 8980016 Minus 145287-145744 404610 9588566 Minus 8958&89725, 90402-90555, 91428-91673 404243 5672609 Plus 74695-75123 406257 7417784 Plus 55821-56037 400575 9886575 Plus 131603-132095 403138 9211494 Minus 164684-165066, 167757-168651 401908 8698760 Minus 126888-127024 403694 7107765 Plus 142925143080, 165505-166186, 167486-16763 400785 8131682 Plus 43113-43967 TABLE 31A : ABOUT 189 GENES DOWN-REGULATED IN GLIOMA COMPARED TO NON-MALIGNANT ADULT BRAIN TISSUE Table 31A lists about 189 genes down-regulated in glioma compared to non-malignant adult brain tissue. These were selected as for Table 30A, except that the numerator was set to the 90th percentile amongst various non-malignant brain specimens, the denominator was set to the 90th percentile value amongst various gliomas, the numerator was greater than or equal to 50 units, and the ratio was greater than or equal to 2. 5 (i. e. 21rfold downregulation in brain tumor vs. normal brain). Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tite : Unigene gene tiUe Protein Domains : Predicted Protein Domains R1 : non-malignant adult brain tissue vs. gliome Pkey ExAccn UniGene ID Unigene Title Protein Domains RI 412524 AA417813 Hs. 44208 hypothetical protein FLJ23153 F420 oxidored ; TM ; SS 14. 5 432874 W94322 Hs. 279651 melanoma inhibitory activity SH3 ; TM ; SS 8. 3 452669 AA216363 Hs. 262958 hypothetical protein DKFZp434B044 SCP, LCCL ; TM ; SS 8. 2 426300 U15979 Hs. 169228 delta-likehomolog (Drosophila) EGF, laminin_EGF ; TM ; SS 8. 2 447990 BE048821 Hs. 20144 small inducible cytokine subfamily IL8 ; SS 7. 3 439477 W69813 Hs. 58042 ESTs, Moderately similar to GFR3_HU GDNF, TPR 7. 1 411602 L01406 Hs. 767 growthhormonereleasinghomlonere 7tm_2, HRM ; TM ; SS 6. 1 417067 AJ001417 Hs. 81086 slutecamerfamily22 (extraneur sugar tCTM ; SS 6. 0 426488 X03350 Hs. 4 alcohol dehydrogenase 18 (class 1), adhzinc ; TM ; 5. 9 447656 NM003726 Hs. 19126 src kinae-associated phosphoprotei SH3, PH ; TM ; 5. 3 436950 L05779 Hs. 113 epoxide hydrolase 2, cytoplasmic abhydrolase, Hydrolase ; TM= 5. 2 406837 R70292 Hs. 156110 immunoglobulin kappa constant 4. 9 410387 A1277367 Hs. 47094 ESTs 4. 8 432855 AF017988 Hs. 279565 secreted frizzled-related protein 5 Fz, NTR ; TM ; SS 4. 7 441499 AW298235 Hs. 101689 ESTs 4. 6 421481 AW391972 Hs. 104696 KIAA1324 protein TM ; SS 4. 5 420255 NM 007289 Hs. 1298 membranemetallo-endopepGdae (neu PepGdase_M13 ; TM ; SS 4. 5 407230 AA157857 Hs. 182265 keratin 19 filanmbZIP ; SS 4. 4 412445 X51362 Hs. 73893 dopaminereceptorD2 7tm_1 ; TM ; SS 4. 3 413966 AA133935 Hs. 173704 ESTs, Moderately similar to A53959 4. 2 415165 AW887604 Hs. 78065 complementcomponent7 Idl recept a, sushi, tsp_1, 4. 2 420103 AA382259 Hs. 95197 aldehyde dehydrogenase 1 family, me aldedh ; TM ; 4. 2 426723 AW003069 Hs. 183860 ESTs GNT-I ; TM ; SS 4. 1 409081 AJ010277 Hs. 50403 T-box 19 T-box ; TM ; 4. 0 407142 AA412535 gb : zt99blO. sl Soares_tesUs_NHT Hom Na_sulph_symp ; TM ; 4. 0 414449 AA557660 Hs. 76152 decorin LRRNT, LRR, LRR, LRRNT 4. 0 444784 012485 Hs. 11951 ectonucleofidepyrophosphatelphos Somatomedin_B, Endonucleas 3. 9 420321 D78761 Hs. 96657 hyothetical protein tsp_1 ; SS 3. 8 401700 Target Exon TM ; 3. 8 418807 NM 004944 Hs. 88646 deoxyribonuclease -like3 Exo_endo_phos ; TM ; SS 3. 8 406746 AA580395 Hs. 279860 tumor protein, transla6onally-cont TCTP ; TM ; 3. 7 449077 AW262836 Hs. 252844 ESTs 3. 7 415718 F30631 Hs. 200237 ESTs isoamylase_N 3. 7 402449 Target Exon pkinase, LRR, LRRCT ; TM ; SS 3. 6 457489 A1693815 Hs. 127179 cryptic gene TM ; SS 3. 6 406743 AA911568 Hs. 279860 tumorprotein, translationally-cont TCTP ; TM ; 3. 6 416950 AL049798 Hs. 80552 dermatopontin 3. 6 451554 A1474866 Hs. 193237 ESTs 3. 6 440708 AF038962 Hs. 7381 voltage-dependent anion channel 3 Euk_porin, Enterotoxin_A, P 3. 5 426095 A1278023 Hs. 89986 ESTs WD40, none 3. 5 406742 Api468091 Hs. 279860 tumor protein, translationally-cont TCTP ; TM ; 3. 5 429343 AK000785 Hs. 199480 Homo sapiens, Similar to epsin 3, c VHS, ENTH, UIM ; SS 3. 4 439457 AF086274 gb : Homo sapiens full lengGh inserd 3 4 408796 AA688292 Hs. 170345 ESTs hormoneJec, zf-C4 3. 4 440659 AF134160 Hs. 7327 claudin 1 PMP22_Caudin ; TM ; SS 3. 4 415042 NM006759 Hs. 77837 UDP-glucose pyrophosphorylase 2 UDPGP ; SS 3. 4 417967 BE244373 Hs. 1119 nuclear receptor subfamily 4, group hormone_rec, zf-C4. none 3. 3 445234 AW137636 Hs. 146059 ESTs 14-3-3, none 3. 3 430511 BE018156 Hs. 2575 calpain 1, (mull) large subunit efhand, Peptidase C2, Calpa 3. 3 420485 AF218586 Hs. 288835 cell death-inducing DFFA-like effec 7tm_1, CIDE-N ; TM ; SS 3. 3 413687 A1522318 Hs. 103819 ESTs TM ; SS 3. 3 428928 BE409838 Hs. 194657 cadherin 1, type 1, E-cadherin (epi cadhenn. Cadherin_C_term, 3. 3 409738 BE222975 Hs. 56205 insulin induced gene 1 3. 3 442046 AA974575 Hs. 287385 ESTs zf-C2H2, SET ; TM ; 3. 2 413127 BE066529 gb : RC3-BT0333-300300-017-a12 BT0333 3. 2 429350 A1754634 Hs. 131987 ESTs MAM ; TM ; 3. 2 427980 AA418305 Hs. 303205 EST LRR, none 3. 2

424498 AB033043 Hs. 149377 hypothetical protein DKFZp761L0424 AIP3 ; TM ; SS 3. 2 435684 NM_001290 Hs. 4980 LIM domain binding 2 LIM bind ; TM ; 3. 2 402632 Target Exon ig ; TM ; SS 3. 1 431130 NM006103 Hs. 2719 HE4 ; epididymis-specific, whey-acid wap ; TM ; SS 3. 1 410636 AA088177 Hs. 172870 ESTs TM ; SS 3. 1 452658 N88604 Hs. 30212 thyroid receptor interacting protei Pa. TM ; 3. 1 453180 N46243 Hs. 110373 ESTs, HighlysimilartoT42626secr laminin_G, LRRCT, none 3. 1 430319 A1480214 Hs. 356075 ninjudn 2 TM ; SS 3. 1 438424 A1912498 Hs. 25895 hypothetical protein FLJ14996 C2 : TM ; 3. 1 456063 NM006744 Hs. 76461 retinot-binding protein 4, inters)) lipocalintTGFwbetatTGFb_p 3. 1 429798 AL117578 Hs. 222909 DKFZP434C128 protein TM ; 3. 1 417677 NM 016055 Hs. 82389 CGI-118 protein 3. 1 443792 A1763073 Hs. 204873 ESTs 3. 1 445861 BE293423 Hs. 11809 single Ig IL-1R-related molecule TIRTM ; 3. 1 407815 AW373860 Hs. 183860 hypothetical protein FU20277 LRR. none 3. 1 456689 NM002251 Hs. 117780 potassium voltage-gated channel, de ion_yans, K_tetra ; TM ; SS 3. 1 446492 AW205115 Hs. 161287 ESTs SPRY, zf-B_box, PMD_D 3. 1 427706 AW971225 Hs. 293800 ESTs, WeakiysimiiartoAW1 HUMAN lO 458008 AA809314 Hs. 123295 ESTs SCAN, zf-C2H2, none 3. 0 449708 A1694598 Hs. 202126 ESTs 3. 0 410132 NM_003480 Hs. 300946 Microfibril-associated glycoprotein TM ; SS 3. 0 423778 Y09267 Hs. 132821 flavin containing monooxygenase 2 FMO-like, pyr_redox ; TM ; S 3. 0 425280 U31519 Hs. 1872 phosphoenolpyruvate carboxykinase 1 PEPCK ; TM ; 3. 0 453177 AW389509 Hs. 223747 ESTs zf-C2H2, none 3. 0 416781 AF072928 Hs. 79877 myotubularin related protein 6 3. 0 447582 BE293520 Hs. 18910 prostate ståecanceroverexpressedgene sugar_tTM ; SS 3. 0 417365 D50683 Hs. 82028 transforming growth factor, beta re pkinase. WD40 ; TM : 3. 0 452540 AW161048 Hs. 150549 ESTs. Weakly similar to T33997 hypo 2. 9 430233 AW367902 Hs. 236443 Homo sapiens mRNA ; cDNA DKFZp564N10 PH, Ets, CH, spectrin, Ca_cha 2. 9 418127 BE243982 Hs. 83532 membrane cofactor protein (CD46, tr sushi ; TM ; SS 2. 9 404445 Target Exon 2. 9 423323 A1951628 Hs. 127007 potassium channel, subfamily K, mem ion trans ; TM ; SS 2. 9 452093 AA447453 Hs. 27860 Homo sapiens mRNA ; cDNA DKFZpS86M07 7tm_1, none 2. 9 427981 BE275986 Hs. 181311 asparaginyl-tRNAsynthetase tRNA-synt_2. tRNA anti, tRN 2. 9 452242 R50956 Hs. 159993 gycosyltransferase 2. 9 440232 A1766925 Hs. 112554 ESTs 2. 9 444634 AW611988 Hs. 197813 ESTs CKS 2. 9 445889 BE465186 Hs. 266958 ESTs TM ; 2. 9 414483 R25513 Hs. 10683 ESTs 2. 9 453500 A) 478427 Hs. 43125 esophageal cancer related gene 4 pr TM ; SS 2. 9 419768 T72104 Hs. 93194 apolipopnotein A-l Apolipoprotein ; SS 2. 9 427804 AL049654 Hs. 180871 protein kinase C, alpha binding pro PDZ ; SS 2. 9 423753 Y11312 Hs. 132463 phosphoinositide-3-kinase, class 2, C2, PI3_PI4 kinase, P13Ka, P 2. 9 430699 AW969847 Hs. 292718 ESTs, WeaklysimilartoRET2 HUMAN lipocalin ; SS 2. 9 427842 AW936961 gb : RC1-DT0029-160200 013-al2 DT0029 efhand, mito_can, none 2. 8 432834 F06459 Hs. 289113 cytochromebSreductae1 (B5R. 1) NAD_binding, FAD_binding_6 2. 8 421435 AW972072 Hs. 372167 ESTs 2. 8 402458 C1002064 : gill 199305OIgblAAG42574. 11 TM ; SS 2. 8 410036 R57171 Hs. 57975 calsequestin 2 (cardiac muscle) Calsequestrin ; SS 2. 8 412570 AA033517 Hs. 74047 electron-transfer-flavoprotein, bet ETF_beta ; SS 2. 8 459439 AW402931 Hs. 352411 gb : UI-HF-BKO-abd-a-01-0-Ul. rl NIH M 2. 8 438622 L03151 gb : Homo sapiens cell-type T-cell im 2. 8 417023 AA192278 Hs. 301596 ESTs, Moderately similar to S65657 2. 8 453281 W46280 Hs. 55940 ESTs, Weakly similar to A25704 syna 2. 8 403028 Target Exon trypsin, trefoil 2. 8 449029 N28989 Hs. 22891 solute carrier family 7 (caGonic a aa_pemieases ; TM ; SS 2. 8 425483 AF231022 Hs. 158159 FAT tumor suppressor (Drosophila) h EGF, cadherin, laminin G ; TM 2. 8 406918 M88357 gb : HomosapiensDNA-bindingpnotein zf-C2H2, KRAB, zf-BED ; TM ; 2. 7 435213 AA092510 Hs. 5985 non-kinase Cdc42 effector protein S TM ; 2. 7 443990 AW205085 Hs. 39557 ESTs 2. 7 451698 Y16187 Hs. 26880 endothelin converting enzyme-like 1 Pepfidase M13 ; TM ; 2. 7 431713 AK000388 Hs. 267997 EHM2gene Band 41 ; TM ; 2. 7 431469 N49424 Hs. 124159 ESTs SH3 2. 7 400386 AF075290 gap juncGon pnotein, alpha 3, 46kD connexin ; TM ; SS 2. 7 406684 X16354 Hs. 50964 carcinoembryonic antigen-related ce ig ; TM ; SS 2. 7 449874 AA135688 Hs. 10083 Homo sapiens, clone IMAGE : 4139786, TM ; 2. 7 403213 NM019595 : HomosapiensintersecEn SH3, efhand, C2, PH, RhoGEF ; T 2. 7 459665 BE159784 Hs. 47647 gb : MRO-HT0408-220300-001-hO6 HT0408 2. 7 421823 N40850 Hs. 28625 ESTs 2. 7 422693 BE300073 Hs. 279860 tumor protein, translaGonally-cont TCTP, none 2. 7 454906 A1219323 Hs. 101077 ESTs, Weakly similar to T22363 hypo TM ; 2. 7 447075 AV662037 Hs. 124740 ESTs, Weakly similar to 138022 hypo TM ; 2. 7 450273 AW296454 Hs. 24743 hypothetical protein FLJ20171 mm, none 2. 7 434340 Api193043 Hs. 128685 ESTs, Weakly similar to T17226 hypo 2. 7 436972 AA284679 Hs. 25640 claudin 3 PMP22_Uaudin ; TM ; SS 2. 7 441379 AW175787 Hs. 334841 selenium binding protein 1 TM ; 2. 7 421143 AB024536 Hs. 102171 immunoglobulinsuperfamilycontaini ig, LRR, LRRNT, LRRCT ; TM ; S 2. 7 422558 NM 006420 Hs. 118249 brefeldinA-inhibitedguaninenucle Sec7, none 2. 7 428900 AA437189 Hs. 352324 Human DNA sequence from clone RP1-6 SS 2. 7 421153 AF009267 Hs. 102238 HomosapienscloneFBA1Cri-du-chat 2. 7 427074 AA527435 Hs. 178589 hepatocellular carcinoma antigen ge efhand ; TM ; 2. 6 448133 AA723157 Hs. 73769 folate receptor 1 (adult) Folate_rec. MiP ; TM ; SS 2. 6 419158 AF031475 Hs. 89648 arginine vasopreSsin (neunophysin I hommoneS, homlone4 ; SS 2. 6

448406 AW772298 Hs. 21103 HomosapiensmRNAcDNADKFzpS64BO7 2. 6 437176 AW176909 Hs. 42346 calcineurin-binding protein calsarc Galactosyl_T ; TM ; SS 2. 6 435075 R51094 Hs. 12400 ESTs 2. 6 403153 Target Exon 2. 6 400387 AF133131 double homeobox, 5 2. 6 425940 AB023184 Hs. 163990 KIAA0967 protein PDZ ; SS 2. 6 416157 NM 003243 Hs. 342874 iransfomminggnowthfætor, betare zona_pellucida ; TM ; SS 2. 6 452554 AW452434 Hs. 58006 ESTs, Weakly similar to ALU5_HUMAN HLH, PAC, PAS, none 2. 6 453247 T80198 Hs. 111806 ESTs vwa, Cache, none 2. 6 407744 AB020629 Hs. 38095 ATP-binding cassette, sub-family A ABC_tran, PRK ; TM ; SS 2. 6 432877 AW974111 Hs. 292477 ESTs Ets, SAMPNT. none 2. 6 450115 A1591038 Hs. 38132 ESTs 2. 6 406337 C14000021 : gij724Z973ldbilBM92547. 1 Peptidase M22 2. 6 430877 NM005269 Hs. 2693 glioma-associated oncogene homolog zf-C2H2 ; SS 2. 6 453874 AW591783 Hs. 36131 collagen,"XIV, alpha I (unduli 2. 6 450493 M93718 Hs. 166373 nitricoxidesynthae3 (endothelia NAD_binding, flavodoxin, FA 2. 6 427620 NM 003705 Hs. 179866 solutecarierfamily25 (mitochond efhand, mitocarr, TM ; SS= 2. 6 446585 AV659397 Hs. 299668 ESTs, Weakly similar to 138022 hypo 2. 6 427223 BE208189 Hs. 174031 cytochromecoxidaesubunitVlb tubulin, FKBP, COX6B, 7tm_1, 2. 6 428111 S76617 Hs. 2243 Blymphoidtyrosinekinae SH2, SH3, pkinase ; SS 2. 6 440133 A1056255 Hs. 133349 ESTs 2. 6 419693 AA133749 Hs. 301350 FXYO domain-containing ion transpor ATP1G1PLM. MAT8 ; TM ; SS 2. 6 417103 Z33905 Hs. 81218 hypothetical protein MGC3597 TPRzf-C3HC4, PHD ; TM ; SS= 2. 6 419100 AA464362 Hs. 6748 hypothetical protein PP1665 squash, GDPD ; TM ; 2. 6 449925 AI342493 Hs. 24192 Homo sapiens cDNA FU20767 fis, do Z6 430937 X53463 Hs. 2704 glutathione peroxidase 2 (gastroint GSHPx ; SS 2. 6 425640 U34051 Hs. 158460 cyclin-dependent kinase 5, regulato CDK5_activator, TM ; 2. 6 409021 AA156640 Hs. 49881 fatty acid binding protein 3, muscl lipocalin, none 2. 6 400538 ENSP00000239776' : BA425A6. 2 (similar TM ; SS 2. 6 446947 AF146747 Hs. 232165 polycythemia rubra vera 1 ; cell sur TM ; SS Z6 408310 AW179023 Hs. 191705 gb : PM3-ST0036-170899-001-eO8 ST0036 2. 6 433032 A1084066 Hs. 20072 myosin regulatory light chain inter Band_41 ; 2. 6 419389 A1074951 Hs. 319095 ESTs DPPIV_N_temm, none 2. 6 453145 R63438 Hs. 183454 HomosapienscDNAFLJ14883fis, clo STT3 ; TM ; SS 2. 6 443460 AL050275 Hs. 9383 DKFZP566D213protein EGF, laminin EGF, EB ; TM ; S 2. 6 421903 AW079940 Hs. 15951 ESTs, WeaklysimilatoS32436coll SS 2. 5 421757 Z20897 Hs. 296259 paraoxonase 3 Arylesterase ; SS 2. 5 428475 AF172940 Hs. 184542 CGI-127 protein 2. 5 424657 AA344719 gb : EST50901 Gall bladder 11 Homo sa 2. 5 432862 AW004958 Hs. 236720 amnionless protein TM ; SS 2. 5 427195 W27230 Hs. 173912 eukaryotic ranslation iniGation f DEAD, helicae_C ; 2. 5 447770 AB032417 Hs. 19545 frizzled (Drosophila) homolog 4 Fz, Frizzled, 7tm 2 ; TM ; SS 2. 5 456523 A1083668 Hs. 50601 hypothetcal protein MGC10986 pkinase, none 2. 5 451846 T65840 Hs. 11762 ESTs 2. 5 432906 BE265489 Hs. 3123 lethal giant larvae (Drosophila) ho WD40 ; TM ; 2. 5 453876 AW021748 Hs. 110406 ESTs, Weakly similar to 138022 hypo 2. 5 441488 AW450935 Hs. 7862 hypothetical protein FLJ20312 TM ; 2. 5 444669 F18939 Hs. 153827 ESTs 2. 5 452497 AA732153 Hs. 27865 Homo sapiens cDNA FLJ21333 fis, cl 2. 5 TABLE 31B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 439457 23338 1 AF086274 W69434 W69517 413127 151610 1 BG007296 BF330853 BF747375 BE066356 BE066292 BF330900 BF747142 BE066419 BF742510 BE066529 BE066298 BF742516 BF746603 BE066274 BF334312 427842 1164138_1 AW936960AW936961M416706R29415 438622 46171_1 L03151 L03155 L03161 424657 896375_1 AW963487 AA365077 AA344719 TABLE 31 C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 401700 3176654 Minus 35416-35534 402449 9796674 Plus 59867-60039, 62588-62828, 63465-63623, 6492 402632 9931268 Plus 101166-101419 404445 7596866 Minus 31112-31423 402458 9796782 Plus 170479-171134 403028 7670577 Minus 114150-114272 403213 7630897 Minus 162572-162739, 164442-164540 403153 9799871 Minus 42232-43389 406337 9213455 Plus 90117-90337 400538 9797838 Plus 8752-9822

TABLE 32A : ABOUT 68 GENES UP-REGULATED IN GLIOMA COMPARED TO NORMAL ADULT TISSUES AND TO NON-MALIGNANT BRAIN TISSUES THAT ARE LIKELY TO ENCODE PROTEINS AMENABLE TO MODULATION BY SMALL MOLECULES, PEPTIDES, OR ANTIBODIES Table 32A lists about 68 genes up-regulated in glioma compared to normal adult tissues and to non-malignant brain tissues that are likely to encode proteins amenable to modulation by small molecules, peptides, or antibodies. These were selected from the starting collection of 59680 probesets on the Afiymehix/Eos-Hu03 GeneChipCV array as follows : the ratio of 'average'glioma to'average'normal adult tissues was greater than or equal to 2. 5, the ratio of'average'glioma to'average'non-malignant brain tissues was greater than or equal to 2. 0, the'average'glioma level was set to the 98th percentile value amongst various glioma specimens, the *average'normal adult issue level was set to the 85th percentile value amongst various non-malignant tissues, the'average'non-malignant brain tissues level was set to the 90th percentile value amongst various non-malignant brain tissues, the 'average'gtioma value was greater than or equal to 50 units, and the predicted protein contained a structural domain that is indicative of having an oncogenic function or of transducing an intracellular signal, or of being modulable by small molecules, pepGdes, or antibodies (e. g. pkinase, death-domain, 7tm, phosphatase, or ion_transporter). Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title Protein Domains : Predicted Protein Domains RI : glioma vs. normal adult tissues and non-malignant brain tissues that are likely to encode proteins Pkey ExAccn UniGene ID Unigene Title Protein Domains R1 424343 AW956360 Hs. 4748 adenylate cyclase activating polype 7tm2, HRM 8. 8 418506 AA084248 Hs. 85339 Unknown protein for MGC : 29643 (form 7. 8 456723 Z43902 Hs. 4748 adenylate cyclase activating polype 7 2, HRM 7. 5 430228 AW950939 Hs. 6382 ESTs, Highly similar to T00391 hypo 7. 1 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel ASC ; TM ; 6. 3 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, TM ; 6. 0 414825 X06370 Hs. 77432 epidermal growth factor receptor (a Furin-like, pkinase, Recep_ 6. 0 423779 AW071837 Hs. 57971 ESTs TNFRc6 5. 5 409638 AW450420 Hs. 21335 ESTs 7tu2. HRM 5. 3 442613 Al004002 Hs. 130522 KvdhanneWinteræGngprotein1 Neur_chan_LBD, Neur_c 5. 2 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 5. 1 424340 AA339036 Hs. 7033 ESTs lig chan, ANF_mceptor, non 5. 0 425115 R44664 Hs. 123956 ESTs 7tm 1 4. 7 446809 AW590171 Hs. 101413 ESTs CaMBD, SK_channel, CaMBD, SK 4. 4 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 k ubiquitin ; SS 4. 4 454360 L78207 Hs. 54470 ATP-binding cassette, sub-family C ABC_tran, ABC_membrane, PRK 4. 2 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity I ig ; TM : SS 4. 2 428141 D50402 Hs. 182611 sotutecamerfamily11 (protonco Nramp ; TM ; 4. 1 435472 AW972330 Hs. 283022 triggering receptor expressed on my ig ; TM ; SS 4. 1 435615 Y15065 Hs. 4975 potassium voltage-gated channel, KO ion trans, KCNQ1 channel ; T 3. 8 448204 At475124 Hs. 170561 ESTs lig chan, SBP bac3 3. 7 433290 R20077 Hs. 302185 Homosapiensclone23618mRNAseque lig_chan, SBP_bæ_3, ANF_re 3. 6 408243 Y00787 Hs. 624 interleukin 8 HLH, PAS, IL8 ; TM ; 3. 6 415849 R20529 Hs. 6806 ESTs 7tm-2, GPS, Gal-Lecbn, HRM, 3. 5 451099 R52795 Hs. 25954 intedeukin 13 receptor, alpha 2 fn3 ; TM ; SS 3. 4 445070 NM000677 Hs. 258 adenosine A3 receptor 7tm_1 ; TM ; SS 3. 4 428037 N47474 Hs. 89230 potassium intermediate/small conduc CaMBD, SK_channel 3. 2 444006 BE395085 Hs. 10086 type I transmembrane protein Fnl4 direcepta. PKD. MHCJ ; TM 3. 1 447143 AW292408 Hs. 152290 ESTs, Highly similar to JC2463 vaso 3. 0 418054 Nom002318 Hs. 83354 lysyl oxidase-like 2 SRCR, Lysyl oxidase ; TM ; S 3. 0 424441 X14850 Hs. 147097 H2A histone family, member X histone, CBFD_NFYB_HMF ; TM= 3. 0 446057 AI420227 Hs. 366053 Trp-p8 transient receptor potential 2. 9 438204 A1589645 Hs. 128690 ESTs 7tm1 2. 9 431674 AA098901 Hs. 301642 G-protein coupled receptor GCV_H Z9 424028 AF055084 Hs. 153692 Homo sapiens cDNA FLJ14354 fis, clo 2. 9 415209 F00183 Hs. 172004 titin 2. 8 438537 AK000511 Hs. 6294 hypothetical protein DKFZp434L1435 tRNA-synt_1 ; TM ; 2. 8 431053 S40369 Hs. 249141 Glutamate receptor subunit lig chan, ANF receptor ; TM= 2. 8 408482 NM_000676 Hs. 45743 adenosineA2b receptor 7tm1 ; TM ; SS 2. 8 414774 X02419 Hs. 77274 plasminogen activator, urokinase kringle, trypsin, plant thi 2. 8 426865 D63476 Hs. 172813 PAK-interacting exchange factor bet SH3, PH, RhoGEF, Terpenesyn 2. 8 430897 U71092 Hs. 248122 Gproteincoupledeceptor24 7tm_1 ; TM ; 2. 7 438993 AA828995 gb : od77bO8. si NCI_CGAP_Ov2 Homo sap EGF, metalthio, integrin B, 2. 7 409552 AL119675 Hs. 54929 phosphorylase kinase, gamma 1 (musc pkinase, Bac-DNA-binding ; T 2. 7 412817 AL037159 Hs. 74619 proteasome (prosome, macropain) 26S PC_rep : TM ; 2. 7 429150 AF120103 Hs. 197366 smoothened (Drosophila) homolog COX8, SHMT, MIF, GST_C, EF1G 2. 7 419508 AW997938 Hs. 90786 ATP-binding cassette, sub-family C ABC_tran, ABC_membrane ; TM= Z7 417880 BE241595 Hs. 82848 selectin L (lymphocyte adhesion mol EGF, lectin_c, sushi ; TM ; S 2. 7 432074 AA525248 Hs. 149723 ESTs Y-phosphatase 2. 6 402154 NM_031896-: Homosapienscalciumcha PMPZ2_Caudin ; TM ; SS 2. 6 431222 X56777 Hs. 273790 zona pellucida glycoprotein 3A (spe zona_pellucida ; TM ; SS 2. 6 419913 AW270040 Hs. 34455 ESTs EPH Ibd, fn3, pkinae, 2. 6 412802 U41518 Hs. 74602 æuaporin 1 (channel-forming integr MIP ; TM ; SS 2. 6 412070 AW893260 gb : CM2-NN0010-100300-111-eO9NN0010 7tm_2, HRM 2. 6 422676 D28481 Hs. 1570 histamine receptor H1 7tm_1 ; TM ; SS 2. 6 422311 AF073515 Hs. 114948 cytokinereceptor-likefætor1 fn3 ; TM ; 2. 6 444381 BE387335 Hs. 283713 hypothetical protein BC014245 Collagen ; TM ; SS 2. 6 419972 AL041465 Hs. 182982 golgin-67 2. 6 418526 BE019020 Hs. 85838 solute carrier family 16 (monocarbo TM ; SS 2. 6 421997 R66740 Hs. 110613 KIAA0220 protein aapermeases. pyddoxal de 2. 6 430181 AF065314 Hs. 234785 cyclicnucleotidegatedchannelalp cNMP binding, ion_lrans ; TM 2. 5 426318 AA375125 Hs. 147112 Homo sapiens cDNA : FU22322 fis, cl EPH Ibd, pkinase, fn3, SAM, n 2. 5 434808 AF155108 Hs. 256150 NY-REN-41 antigen TM ; 2. 5 418843 AJ251016 Hs. 89230 potassiumintemmediatevsmallconduc CaMBD, SK channel ; TM ; SS= 2. 5 410290 AA402307 Hs. 322844 hypothetical protein DKFZp564A176 Sema, PSI, TIG, integrin_B ; T 2. 5

424909 S78187 Hs. 153752 cell division cycle 258 Rhodanese ; SS 2. 5 408369 R38438 Hs. 182575 SLC15A2 Solute carrier family 15 (H PTR2 ; TM ; 2. 5 414561 A1064813 Hs. 195155 Homo sapiens amino acid transports Aatrans : TM ; 2. 5 TABLE 328 : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 438993 2580163 1 A1926361 AA834879 AA828995 412070 287551 1 BG820657 AW890808 BF904755 AW893260 B1034684 BF963423 BF961550 M85689 TABLE 32C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 481495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 402154 8516165 Minus 125299-125494 TABLE 33A : ABOUT 798 GENES UP-REGULATED IN KIDNEY CANCER Table 33A lists about 798 genes up-regulated in kidney cancer compared to normal adult tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average'kidney cancer to'average"normal adult Gssues was greater than or equal to 3. 0. The'average kidney cancer level was set to the 90th percentile amongst various kidney cancers. The'average'normal adult tissue level was set to the 90th percentile amongst various non-malignant tissues. In order to remove gene- specific background levels of non-specific hybridization, the 15th percentile value amongst the various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD Unigene number Unigene Title : Unigene gene 6tle R1 : Ratio of tumor to normal tissue Pkey ExAccn UniGenelD UnigeneTite R1 421471 U90545 Hs. 104635 solutecanierfamily17 (sodiumphospha 1007. 4 445178 A1792241 Hs. 129614 kidney-specific membrane protein 438. 0 452401 NM 007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 336. 4 421727 Y13153 Hs. 107318 kynurenine 3-monooxygenase (kynurenine 3 323. 6 440304 BE159984 Hs. 125395 ESTs 295. 0 436878 BE465204 Hs. 47448 ESTs 258. 8 452795 AW392555 Hs. 18878 hypothetical protein FLJ21620 258. 6 421155 H87879 Hs. 102267 iysyloxidae 251. 8 426471 M22440 Hs. 170009 transforming growth factor, alpha 224. 6 421478 A1683243 Hs. 97258 ESTs 212. 6 424086 A1351010 Hs. 102267 lysyl oxidase 199. 2 428296 NM 003058 Hs. 183572 solute carrier family 22 (organic cation 186. 4 426890 AA393167 Hs. 41294 ESTs 183. 4 441031 A1110684 Hs. 7645 fibrinogen, Bbetapoiypeptide 174. 0 411642 NM_014932 Hs. 71132 neuroligin 1 172. 4 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 161. 4 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 151. 0 438966 AW979074 gb : EST391184 MAGE resequences, MAGP Homo 135. 0 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 134. 8 453160 Al263307 Hs. 146228 ESTs 132. 6 452431 U88879 Hs. 29499 toll-like receptor 3 130. 6 423508 AW604297 Hs. 129711 hepatitis A virus cellular receptor 1 120. 4 420642 AK001520 Hs. 99545 Homo sapiens cDNA FLJ10658 fis, clone NT 112. 6 407975 X89426 Hs. 41716 endothelial cell-specific molecule 1 (NO 111. 8 431708 At698136 Hs. 108873 ESTs 109. 8 446460 AW013999 Hs. 150164 ESTs 103. 6 443450 N66045 Hs. 133529 ESTs 103. 0 432865 A1753709 Hs. 152484 ESTs 101. 4 442438 AA995998 gb : os26b03. sl NCI CGAP KidS Homo sapiens 98. 8 433447 U29195 Hs. 3281 neuronal pentraxin 11 93 5 440311 Api733079 Hs. 125407 ESTs. Moderately similar to ALUE HUMAN ! 98. 2 415076 NM000857 Hs. 77890 guanylate cyclase 1, soluble, beta 3 97. 0 437157 BE048860 Hs. 120655 ESTs 94. 4 453319 A1985369 Hs. 20117 ESTs 91. 4 447046 AA326187 Hs. 17170 G protein-coupled receptor 4 90. 2 439169 A1912122 Hs. 41095 ESTs 86. 6 431870 AW449902 Hs. 105500 ESTs 84. 4 438993 AA828995 gb : od77b08. sl NCl_CGAP_Ov2 Homo sapiens 83. 8 445279 R41900 Hs. 22245 ESTs 82. 4 451592 A1805416 Hs. 213897 ESTs 79. 4 422966 AV648419 Hs. 122613 dimethylglycine dehydrogenae precursor 78. 8 423109 M59305 Hs. 123655 natriureUcpepUdereceptorC/guanylate 78. 0 415989 A1267700 Hs. 111128 ESTs 77. 0 422544 AB018259 Hs. 118140 KIAA0716 gene product 74. 8 425878 AW964806 Hs. 38085 ESTs. Weakly similar to putative glycine 74. 8 429352 AK001512 Hs. 200097 hypotheúcaproteinFW10650 73. 0

453392 U23752 Hs. 32964 SRY (sex determining region Yybox 11 72. 2 441665 A1301355 Hs. 151285 ESTs 71. 6 435094 A1560129 Hs. 277523 EST 71. 2 403345 69. 6 430440 X52599 Hs. 2561 nerve growth factor, beta polypeptide 69. 0 440482 AA886658 Hs. 50873 ESTs 67. 6 457100 AA417878 Hs. 48401 ESTs, WeakiysimilartoALU8 HUMANALUS 67. 0 420637 AW976153 gb : EST388262 MAGE resequences, MAGN Homo 65. 2 407905 AW103655 Hs. 252905 ESTs 63. 2 422998 AK000588 Hs. 122939 hypothetical protein FLJ20581 61. 8 432267 AK000872 Hs. 274227 Homo sapiens cDNA FW10010 fis, clone HE 61. 2 449448 D60730 Hs. 57471 ESTs 60. 6 431941 AK000106 Hs. 272227 Homo sapiens DNA FLJ20099 fis, clone CO 59. 8 419752 AA249573 Hs. 152618 ESTs 58. 4 449579 AW207260 Hs. 134014 prostate cancer associated protein 6 58. 2 408609 AA330431 Hs. 640 calcitonin receptor 57. 4 451009 AA013140 Hs. 115707 ESTs 57. 2 435610 AI862767 Hs. 114157 ESTs, WeaklysimilatoputaUvep150lH 56. 4 411893 R82845 Hs. 273789 ESTs. 56. 2 415227 AW821113 Hs. 72402 ESTs 55. 2 433859 AW896758 Hs. 163925 ESTs 55. 0 450459 A1697193 Hs. 299254 ESTs 54. 4 400302 N48056 Hs. 1915 folate hydrolase (prostate-specific memb 53. 4 421831 AA298836 Hs. 22026 ESTs 52. 8 438817 A1023799 Hs. 163242 ESTs 52. 1 449101 AA205847 Hs. 23016 G protein-coupled receptor 52. 0 410025 BE220489 Hs. 113592 ESTs 51. 8 423685 BE350494 Hs. 49753 Homo sapiens mRNA for KIAA1561 protein, 48. 0 436751 AA732217 Hs. 294054 ESTs 46. 6 445424 A8028945 Hs. 12696 cortactinSH3 domain-binding protein 45. 4 444059 R69743 Hs. 75442 albumin 44. 8 442671 A1005668 Hs. 134779 EST 44. 4 445657 AW612141 Hs. 279575 ESTs 44. 3 452891 N75582 Hs. 212875 ESTs, Weakly similar to KIAA0357 (H. sapi 44. 0 423735 AA330259 gb : EST33963 Embryo, 12 week 11 Homo sapi 43. 8 422553 A1697720 Hs. 171455 ESTs 43. 6 452461 N78223 Hs. 108106 transcription factor 42. 8 408430 S79876 Hs. 44926 dipeptidylpeptidase IV (C026, adenosine 42. 6 452240 A1591147 Hs. 61232 ESTs 41. 7 445186 AW614544 Hs. 123641 protein tyrosine phosphatase, recepto t 41. 4 452788 AW294571 Hs. 136040 ESTs 41. 4 419287 X91906 Hs. 89872 chloride channel 5 (nephrolithiasis 2, X 40. 6 428822 W28418 Hs. 301148 potassium voltage-gated channel, Isk-rel 40. 2 412359 AW837985 gb : QV3-LT0048-140200-083-eO5 LT0048 Homo 40. 0 434208 T92641 Hs. 127648 hypothetical protein PR02176 39. 2 442168 A1253165 Hs. 146022 ESTs 38. 8 400792 AA635062 Hs. 50094 Homo sapiens mRNA ; cDNA DKFZp43400515 (f 38. 6 445900 AF070526 Hs. 13429 Homo sapiens clone 24787 mRNA sequence 38. 4 444743 AA045648 Hs. 11817 nudix (nucleoside diphosphate linked moi 38. 4 428795 R45503 Hs. 97469 ESTs, Weakly similar to 149698 alpha-1, 3 37. 6 406411 37. 6 423657 AL045128 Hs. 1691 glucan (1, 4-alpha-), branching enzyme 1 37. 5 417218 AA005247 Hs. 285754 met proto-oncogene (hepatocyte growth ta 37. 2 448788 A1570286 Hs. 107070 ESTs 37. 2 441826 AW503603 Hs. 129915 phosphotriesterase related 37. 0 409263 AA069573 Hs. 50319 ESTs 36. 8 425577 BE464496 Hs. 280977 ESTs 36. 2 452249 BE394412 Hs. 61252 ESTs 34. 8 435986 AA703158 Hs. 187848 ESTs 34. 4 417236 Api908497 Hs. 170737 Homo sapiens cDNA : FLJ23251 fis, clone C 33. 8 440234 AW117264 Hs. 126252 ESTs 33. 8 435334 R94223 Hs. 117747 ESTs 33. 2 410153 BE311926 Hs. 15830 Homo sapiens cDNA FW12691 fis, clone NT 33. 1 424871 NM004525 Hs. 153595 low density lipoprotein-related protein 32. 8 420908 AL049974 Hs. 100261 Homo sapiens mRNA ; cDNA DKFZpS64B222 (fr 32 4 423992 AW898292 Hs. 137206 Homo sapiens mRNA, cDNA DKFZpS64H1663 (f 32. 4 451050 AW937420 Hs. 69662 ESTs 32. 0 449034 A1624049 gb : ts41a09. x1 NCI CGAP_Ut1 Homo sapiens 31. 6 434539 AW748078 Hs. 214410 ESTs 31. 0 431595 AA508196 gb : nh60fO7. sl NC_CGAP_Pr3 Homo sapiens 30. 6 449625 NM 014253 Hs. 23796 odz (odd Oz/ten-m, Drosophila) homolog 1 30. 5 448243 AW369771 Hs. 77496 small nuclear dbonucleoprotein polypept 30. 4 413573 A1733859 Hs. 149089 ESTs 30. 2 421037 A1684808 Hs. 197653 ESTs 30. 2 449353 AA001220 Hs. 271369 ESTs 30. 2 416548 H62953 gb : yr47f06. r1 Soares fetal liver spleen 29. 6 423020 AA383092 Hs. 1608 replication protein A3 (14kD) 29. 6 422420 U03398 Hs. 1524 tumor necrosis factor (ligand) superfami 29. 6 459508 R83265 Hs. 205956 ESTs 29. 2 414245 BE148072 Hs. 75850 WAS protein family, member 1 28. 8 424565 AW102723 Hs. 75295 guanylate cyclase 1, soluble, alpha 3 28. 6 445925 Api733820 Hs. 145664 ESTs 28. 4 412616 AW970584 Hs. 291033 ESTs 28. 0

424638 A1472106 Hs. 49303 Homo sapiens cDNA FW 11663 fis, clone HE 27. 6 445885 A1734009 Hs. 127699 KIAA1603 protein 27. 6 410247 AF181721 Hs. 61345 RU2S 27. 4 406414 27. 2 435951 AF269162 Hs. 41267 c21orf7formA-D 27. 2 458680 N73773 Hs. 282950 ESTs 27. 0 419948 AB041035 Hs. 93847 NADPH oxidase 4 26. 4 423276 AC003034 Hs. 126261 HomosapiensChromosome16BACdoneCIT 26. 3 427457 AW779105 Hs. 164682 ESTs, Weakly similar to ORF2 consensus s 26. 0 446346 A1290205 gb : ql79gO6. x1 Soares_NhHMPu_S1 Homo sapi 26. 0 448595 AB014544 Hs. 21572 KIAA0644 gene product 25. 8 419569 Al971651 Hs. 91143 jagged 1 (Aagille syndrome) 25. 6 433242 AB040938 Hs. 113940 K) AA1505 protein 25. 6 453118 AW195849 Hs. 252757 ESTs 25. 6 412209 AW901456 gb : RCO-NN1012-270300-031-c07 NN1012 Homo 25. 2 429710 AI337113 Hs. 146025 Homo sapiens cDNA : FLJ23594 fis, clone L 25. 2 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 24. 6 436788 AA766908 Hs. 259047 ESTs 24. 4 427660 Api741320 Hs. 114121 HomosapienscDNA : FLJ23228 fis, clone C 24. 4 419172 AW338625 Hs. 22120 ESTs 24. 3 436061 AI248584 Hs. 190745 Homo sapiens cDNA : PU21326 fis, done C 24. 2 413623 AA825721 Hs. 246973 ESTs 24. 0 407615 AW753085 gb : PM1-CT0247-151299-OO5-a03 CT0247 Homo 23. 8 452466 N84635 Hs. 29664 Human DNA sequence from clone 682J 15 on 23. 8 432809 AA565509 Hs. 131703 ESTs 23. 7 440102 A1672443 Hs. 131190 ESTs 23. 6 451559 AL119980 Hs. 128857 ESTs 23. 2 410811 AW805687 Hs. 300648 ESTs 23. 0 416778 M16505 Hs. 79876 steroid sutfatae (microsomal), arylsulf 23. 0 453628 AW243307 Hs. 170187 ESTs 22. 8 401352 22. 6 451561 N52812 Hs. 177403 ESTs 22. 6 401976 22. 4 410658 AW105231 Hs. 192035 ESTs 22. 4 416220 N49776 Hs. 121773 ESTs 22. 2 424073 U03493 Hs. 138959 gap junction protein, alpha 7, 45kD (con 22. 0 444575 Al264647 Hs. 22545 Homo sapiens cDNA FW12935 fis, ctone NT 22. 0 444144 BE159397 Hs. 7736 hypothetical protein 21. 8 438504 AW665281 Hs. 224625 ESTs 21. 2 439157 AA912737 Hs. 20160 ESTs 20. 8 429006 AA443143 Hs. 50929 Homo sapiens cDNA FLJ13842 fis, clone TH 20. 5 442006 AW975183 Hs. 292663 ESTs 20. 2 409569 AW573153 Hs. 256216 ESTs 19. 8 421160 AL080215 Hs. 102301 HomosapiensmRNA ; cDNA DKFZp586J0323 (t 19. 8 404200 19. 6 446591 H44186 Hs. 15456 PDZ domain containing 1'19. 2 420218 AW958037 Hs. 22437 Homo sapiens cDNA : FU23366 fis, clone H 18. 9 408390 AA054222 Hs. 40400 ESTs 18. 8 444038 AW134509 Hs. 135077 ESTs 18. 8 446443 AV659082 Hs. 134228 ESTs 18. 8 442204 A1635450 Hs. 21914 ESTs 18. 4 451177 A1969716 Hs. 13034 ESTs 18. 2 453931 AL121278 Hs. 25144 ESTs 18. 1 437212 A1765021 Hs. 210775 ESTs 18. 1 431806 AF186114 Hs. 270737 tumor necrosis factor (ligand) superfami 18. 0 451659 BE379761 Hs. 14248 ESTs, WeaklysimilartoALU8_HUMANALUS 17. 8 423909 AJ223183 Hs. 135194 immunoglobulinsuperfamily, member6 17. 6 441082 AW444804 Hs. 202655 ESTs 17. 6 446259 AA425204 Hs. 42278 Homo sapiens cDNA FLJ 13391 fis, clone PL 17. 6 423609 AA328348 Hs. 218289 ESTs 17. 4 428301 AW628666 Hs. 98440 ESTs 17. 4 446364 AB006624 Hs. 14912 KIAA0286 protein 17. 4 419983 W55956 Hs. 94030 Homo sapiens mRNA : cDNA DKFZp586E1624 (f 17. 0 424929 A1640761 Hs. 224988 ESTs 17. 0 425695 NM_005401 Hs. 159238 protein tyrosine phosphatase, non-recept 17. 0 449122 Al631310 Hs. 196955 ESTs 17. 0 409519 AA075368 gb : zm86h10. rl Stratageneovanancancer 16. 8 410947 AK000305 Hs. 67055 hypothetical protein FU20298 16. 8 418053 AA211493 gb : zn55dO6. s1 Stratagenemuscle937209H 16. 8 433225 AW816515 Hs. 173540 ATPase, Gass V, type 10D 16. 8 443204 AW205878 Hs. 29643 Homo sapiens CDNA FU13103 fis, clone NT 16. 6 421002 AF116030 Hs. 100932 transcription factor 17 16. 5 419296 AA236115 Hs. 120785 ESTs 16. 2 421659 NM014459 Hs. 106511 protocadherin 17 16. 0 417589 T82075 Hs. 13911 ESTs 16. 0 446057 A1420227 Hs. 149358 ESTs 15. 8 434636 AA083764 Hs. 241334 ESTs 15. 6 446797 Al682536 Hs. 163495 Homo sapiens CDNA FU 13608 fis, clone PL 15. 6 443718 A1083580 Hs. 221373 ESTs 15. 4 409748 A1670776 Hs. 20961 ESTs 15. 2 443211 A1128388 Hs. 143655 ESTs 15. 0 428911 Z43846 Hs. 194478 Homo sapiens mRNA ; cDNA DKFZp43401572 (f 14. 9 444692 AW779922 Hs. 145047 ESTs 14. 8

445436 Api224105 Hs. 151408 ESTs 14. 6 408684 R61377 Hs. 12727 hypothetical protein FW21610 14. 5 405943 14. 4 406291 14. 4 458679 AW975460 Hs. 143563 ESTs 14. 4 450152 A1138635 Hs. 22968 ESTs 14. 4 403899 14. 2 454490 AW797778 gb : CM2-UM0041-250200-104-dO2 UM0041 Homo 14. 2 451807 W52854 Hs. 27099 DKFZP564J0863 protein 14. 0 452453 Al902519 gb : QV-BT009-101198-051 BT009Homosapien 13. 8 447499 AW262580 Hs. 147674 KIAA1621 protein 13. 8 406598 13. 6 430939 A1269471 Hs. 187018 ESTs 13. 4 443316 Al478463 Hs. 18443 ESTs 13. 4 408034 N26639 Hs. 42192 Human EST clone 251800 mariner transposo 13. 2 428508 BE252383 Hs. 184668 SBB131 protein 13. 2 447934 AW631440 Hs. 165596 ESTs 13. 2 406671 AA129547 Hs. 285754 met proto-oncogene (hepatocyte growth fa 13. 1 438199 AW016531 Hs. 122147 ESTs 13. 0 415511 Api732617 Hs. 182362 ESTs 12. 9 426920 AA393351 Hs. 132121 ESTs 12. 8 447311 R37010 Hs. 33417 Homo sapiens cDNA : FLJ22806 fis, clone K 12. 6 423321 AB013885 Hs. 126926 beta-ureidopropionase 12. 5 403622 12. 4 439759 AL359055 Hs. 67709 Homo sapiens mRNA full length insert cDN 12. 4 422317 NM_001147 Hs. 115181 angiopoieGn2 12. 2 428637 AW979268 gb : EST391378 MAGE resequences. MAGP Homo 12. 2 445717 AW664658 Hs. 149332 ESTs 12. 2 418413 R95735 Hs. 117753 ESTs, Weakly similar to antigen of the m 12. 1 405336 12. 0 437100 A ! 761073 Hs. 14535 Homo sapiens cDNA : FLJ22314 fis, clone N 12. 0 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 12. 0 414923 AW445008 Hs. 77637 homeo box A4 11. 9 432009 AL137424 gb : HomosapiensmRNA ; cDNADKFZp761G2123 11. 8 433326 A1379486 Hs. 159430 ESTs 11. 8 453955 AW579207 gb : RC1-DT0029120100-011-hO1 DT0029Homo 11. 8 407510 U96191 gb : Humantrophoblathypoxia-regulatedf 11. 6 433231 AB040926 Hs. 143552 KIAA1493 protein 11. 6 451651 A1097337 Hs. 88977 hypotheticalproteindJ511E16. 2 11. 6 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 11. 4 405609 11. 4 418912 Nom-000685 Hs. 89472 angiotensin receptor 1 11. 4 421306 AA806207 Hs. 125889 ESTs 11. 4 428721 X02158 Hs. 2303 erythropoietin 11. 4 419255 AA235672 Hs. 87491 ESTs 11. 4 450006 A1241555 Hs. 60171 ESTs 11. 3 435420 A1928513 Hs. 59203 ESTs 11. 2 449802 AW901804 Hs. 23984 hypothetical protein FU20147 11. 2 424647 W67751 Hs. 137308 ESTs 11. 0 435758 A1242163 Hs. 22670 chromodomain helicase DNA binding protei 11. 0 404347 10. 8 438664 A1911173 Hs. 213722 ESTs 10. 8 429125 AA446854 Hs. 271004 ESTs 10. 7 416560 R02818 Hs. 14102 ESTs 10. 6 429945 NM006729 Hs. 226483 diaphanous (Drosophila, homolog) 2 10. 6 435085 AW130284 Hs. 192752 ESTs. Moderately similar to NSD1 protein 10. 6 442409 BE208843 Hs. 129544 ESTs, Weakly similar to ORF YLL027w [S. c 10. 6 450644 AW505496 Hs. 281215 ESTs 10. 6 448298 AW137134 Hs. 187203 ESTs 10. 4 404115 10. 2 406242 10. 2 420757 X78592 Hs. 99915 androgenreceptor (dihydrotestosteroner 10. 2 452588 AA889120 Hs. 110637 homeo box A10 10. 2 457233 A1355009 Hs. 221698 ESTs 10. 2 416185 AW975861 Hs. 291995 ESTs 10. 2 446152 A1292036 Hs. 150028 ESTs 10. 1 446298 AF187813 Hs. 14637 kidney-and liver-specific gene 10. 1 423637 AL137279 Hs. 130187 Homo sapiens mRNA ; cDNA DKFZp43401214 (f 10. 0 442405 BE465247 Hs. 129530 ESTs 9. 9 419213 AW749146 gb : PMO-BT0340-170100404eO3 BT0340 Homo 9. 8 420840 A1915836 Hs. 294008 ESTs 9. 8 423355 AA324856 Hs. 257510 ESTs 9. 8 444929 A1685841 Hs. 161354 ESTs 9. 8 423811 AW299598 Hs. 50895 homeo box C4 9. 8 433527 AW235613 Hs. 133020 ESTs 9. 6 429975 A1167145 Hs. 165538 ESTs 9. 6 439979 AW600291 Hs. 6823 hypothetical protein FU10430 9. 5 433703 AA210863 Hs. 3532 nemo-like kinase 9. 2 417404 NM007350 Hs. 82101 pleckstrin horrkology-like domain, family 9. 2 451621 A1879148 Hs. 26770 fatty acid binding protein 7, brain 9. 2 406992 S82472 gb : beta-pol=DNA polymerase beta (exon a 9. 2 419699 AA248998 Hs. 31246 ESTs 9. 2 443740 R56434 Hs. 21062 ESTs 9. 2

422728 AW937826 Hs. 103262 ESTs 9. 2 436961 AW375974 Hs. 156704 ESTs 9. 2 431385 BE178536 Hs. 11090 high affinity immunoglobulin epsilon rec 9. 1 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAAt 330 protein 9. 1 424115 AA335497 Hs. 293965 ESTs 9. 0 402045 9. 0 433426 H69125 Hs. 133525 ESTs 9. 0 425493 AW363582 Hs. 75323 prohibit. 9. 0 447641 BE619186 gb : 601472933F1 NIH_MGC_68 Homo sapiens c 9. 0 403095 8. 8 407942 AA378608 Hs. 5894 hypothetical protein FU10305 8. 8 423126 AA322245 Hs. 290165 ESTs 8. 8 408134 AK000184 Hs. 42945 acid sphingomyelinase-like phosphodieste 8. 7 450375 AA009647 Hs. 8850 a disintegrin and metalloproteinae doma 8. 6 443647 AV653846 Hs. 126261 Homo sapiens Chromosome 16 BAC clone CIT 8. 6 401439 8. 6 449532 W74653 Hs. 271593 ESTs 8. 6 453197 Api916269 Hs. 109057 ESTs, Weakly similar to ALU5 HUMAN ALU S 8. 6 448450 BE612490 gb : 601451834F1 NlH_MGC_66Homosapiensc 8. 5 425176 AW015644 Hs. 301430 ESTs, ModeratelysimilartoTEF1_HUMANT 8. 4 407721 Y12735 Hs. 38018 dual-specificity tyrosine- (Yyphosphoryl 8. 4 402921 8. 4 428133 AW167727 Hs. 11873 ESTs 8. 4 419503 AA243642 Hs. 137422 ESTs 8. 4 452644 AW452616 Hs. 212481 ESTs 8. 4 452259 AA317439 Hs. 28707 signal sequence receptor, gamma (translo 8. 4 409695 AA296961 gb : EST112514 Adrenal gland tumor Homo sa 8. 3 418076 R61388 Hs. 6724 ESTs 8. 3 402696 8. 3 423099 Nom-002837 Hs. 123641 protein tyrosine phosphatase, receptort 8. 3 413998 AW103807 Hs. 243933 ESTs 8. 2 410008 AA079552 gb : zm20hl2. sl Stratagene pancreas (93720 8. 2 416623 N74925 Hs. 38761 Homo sapiens cDNA : FLJ21564 fis, clone C 8. 2 450001 NM001044 Hs. 406 solutecanierfamily6 (neurotransmitte 8. 1 435496 AW840171 Hs. 265398 ESTs, Weakly similar to transformation-r 8. 0 413627 BE182082 Hs. 246973 ESTs 8. 0 415713 AW968573 gb : EST380649 MAGE resequences, MAGJ Homo 8. 0 426695 AW118191 Hs. 112729 ESTs 8. 0 452284 AW451426 Hs. 252740 ESTs 8. 0 454933 BE141714 gb : QVO-HT0101-061099-032-c04 HT0101 Homo 8. 0 426269 H15302 Hs. 168950 Homo sapiens mRNA ; cDNA DKFZp566A1046 (f 8. 0 418882 NM 004996 Hs. 89433 ATP-binding cassette, sub-family C (CFTR 8. 0 444107 T46839 Hs. 10319 UDP glycosyltransferase 2 family, polype 7. 9 445740 T78281 Hs. 13226 Homosapiensclone25181 mRNAsequence 7. 9 433190 M26901 Hs. 3210 renin 7. 8 432777 AA564991 Hs. 269477 ESTs 7. 8 449444 AW818436 Hs. 23590 solute carrier family 16 (monocarboxylic 7. 7 444042 NM 004915 Hs. 10237 ATP-binding cassette, sub-family G (WHIT 7. 7 434032 AW009951 Hs. 206892 ESTs 7. 7 419750 AL079741 Hs. 183114 Homo sapiens CDNA FU 14236 fis, clone NT 7. 6 439024 R96696 Hs. 35598 ESTs 7. 6 437205 AL110232 gb : Homo sapiens mRNA ; cDNA DKFZp564D2071 7. 4 446030 AF131805 Hs. 13544 Homosapiensclone24850mRNAsequence 7. 4 446311 AW007294 Hs. 149795 ESTs, Weakly similar to ALU1_HUMAN ALU S 7. 4 452883 X80031 Hs. 150318 ESTs 7. 4 448253 H25899 Hs. 201591 ESTs 7. 4 406030 7. 4 437084 A1911516 Hs. 127811 ESTs 7. 3 435013 H91923 Hs. 110024 NADH : ubiquinone oxidoreductase MLRO subu 7. 3 432143 AL040183 Hs. 123484 ESTs, Weakly similar to The KIAA0149 gen 7. 3 409594 AA076118 gb : zm18e06. s1 Stratagene pancreas (93720 7. 2 425151 AA351814 Hs. 298678 ESTs 7. 2 448582 A1538880 Hs. 94812 ESTs 7. 2 455068 A1807894 Hs. 27910 centrosomal protein 2 7. 2 406504 7. 2 428395 AA427992 Hs. 104885 ESTs, Weakly similar to zinc finger prot 7. 2 421102 A1470093 Hs. 89217 ESTs 7. 2 423161 AL049227 Hs. 124776 Homo sapiens mRNA ; cDNA DKFZp564N1116 (f 7. 1 410534 AW905138 gb : QVO-NN1071-280400-207-gO7 NN1071 Homo 7. 1 415084 M19267 Hs. 77899 tropomyosin 1 (alpha) 7. 0 410274 AA381807 Hs. 61762 hypoxia-inducible protein 2 7. 0 439416 W58294 Hs. 56254 ESTs 6. 9 420036 R60336 Hs. 52792 Homo sapiens mRNA ; cDNA DKFZp58611823 (f 6. 8 423349 AF010258 Hs. 127428 homeo box A9 6. 8 413070 AA126776 gb : zn8&11. sl Stratagenelungcacinoma 6. 8 449361 AW207890 Hs. 201918 ESTs 6. 8 459309 AA040620 Hs. 109144 ESTs 6. 8 408771 AW732573 Hs. 47584 potassium voltage-gated channel, delayed 6. 8 416462 W92845 gb : zh80fO5. ri Soaresjetaijiver spfeen 6. 8 447835 AW591623 Hs. 164129 ESTs 6. 7 403563 6. 7 427897 NM017413 Hs. 181060 apelin ; peptide ligand for APJ receptor 6. 6 422063 BE156476 gb : QVO-HT0368-040100-082-c05 HT0368 Homo 6. 6

455275 AW977806 gb : EST389810 MAGE resequences, MAGO Homo 6. 6 441350 AB020690 Hs. 7782 paraneoplastic antigen MA2 6. 6 445575 Z25368 Hs. 172004 titin 6. 6 446075 AW451457 Hs. 279179 ESTs 6. 6 405963 6. 6 423049 X59373 Hs. 188023 ESTs 6. 6 436456 AW292677 Hs. 65909 ESTs 6. 5 420273 A1652864 Hs. 197257 ESTs 6. 5 420831 AA280824 Hs. 190035 ESTs 6. 4 423739 AA398155 Hs. 97600 ESTs 6. 4 441559 AA938448 Hs. 259733 ESTs 6. 4 433999 AA778212 Hs. 191869 ESTs 6. 4 439703 AF086538 Hs. 196245 ESTs 6. 4 433757 A1949974 Hs. 152670 ESTs 6. 3 422095 Api868872 Hs. 288966 ceruloplasmin (ferroxidase) 6. 3 415138 C18356 Hs. 78045 tissue factor pathway inhibitor 2 6. 3 448515 H68441 Hs. 13528 Homo sapiens cDNA FU14054 fis, clone HE 6. 3 443595 AF169312 Hs. 9613 PPAR (gamma) angiopoieGn related protein 6. 3 429357 AA779725 Hs. 164589 ESTs 6. 3 404939 6. 3 417071 N58820 Hs. 275133 ESTs 6. 2 436209 AW850417 Hs. 254020 ESTs, Moderately similar to unnamed prot 6. 2 403111 6. 2 448796 AA147829 Hs. 33193 ESTs, Highly similar to AC007228 3 BC372 6. 2 442353 BE379594 Hs. 49136 ESTs 6. 2 451110 A1955040 Hs. 301584 ESTs 6. 1 420092 AA814043 Hs. 88045 ESTs 6. 1 441801 AW242799 Hs. 211874 ESTs 6. 0 407500 U43279 gb : Human nucleoporin nup 36 mRNA, comple 6. 0 450864 R64139 Hs. 205225 ESTs 6. 0 455711 BE069465 gb : RC2-BT0388-290100-012-all BT0388Homo 6. 0 405394 6. 0 436476 AA326108 Hs. 53631 ESTs, Weakly similar to enhancer-of-spli 6. 0 454392 BE260893 gb : 601150677FlNIH MGC_19Homosapiensc 6. 0 414575 H11257 Hs. 295233 ESTs 5. 9 435767 H73505 Hs. 117874 ESTs 5. 9 445495 BE622641 Hs. 38489 ESTs 5. 9 428372 AK000684 Hs. 183887 hypothetical protein FLJ22104 5. 9 436464 A1016176 Hs. 269783 ESTs, Weakly similar to ALU1 HUMAN ALU S 5. 9 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 5. 9 402421 5. 8 417038 T85230 gb : yd33fO2. r1 Soares fetal liver spleen 5. 8 436461 AW511956 Hs. 293261 ESTs 5. 8 440870 Api687284 Hs. 150539 Homo sapiens cDNA FLJ13793 fis, clone TH 5. 8 452281 T93500 Hs. 28792 HomosapienscDNAFW11041 fis, clonePL 5. 8 417280 AW173116 Hs. 262206 ESTs 5. 7 437259 A1377755 Hs. 120695 ESTs 5. 7 425717 X07282 Hs. 171495 retinoic acid receptor, beta 5. 7 443614 AV655386 Hs. 7645 fibrinogen, B beta polypeptide 5. 7 450625 AW970107 gb : EST382188 MAGE resequences, MAGK Homo 5. 6 425305 AA363025 Hs. 155572 Humanclone23801 mRNAsequence 5. 6 430371 D87466 Hs. 240112 KIAA0276 protein 5. 6 430499 AW969408 Hs. 231991 ESTs 5. 6 427920 Z11502 Hs. 181107 annexinA13 5. 6 449318 AW236021 Hs. 108788 ESTs, WeaklysimdartozestelD. melanog 5. 6 407864 AF069291 Hs. 40539 chromosome 8 open reading frame 1 5. 5 410754 T63840 gb : yc16b10. sl Stratagenelung (937210) H 5. 5 415286 AW249540 Hs. 72548 ESTs 5. 5 443297 A1049864 Hs. 133029 ESTs 5. 5 440138 AB033023 Hs. 6982 hypothetical protein FLJ10201 5. 5 441006 AW605267 Hs. 7627 CGI-60 protein 5. 4 409348 A1401535 Hs. 146090 ESTs 5. 4 449679 A1823951 Hs. 296668 Homo sapiens CDNA FU 11846 fis, clone HE 5. 4 408938 AA059013 Hs. 22607 ESTs 5. 4 456411 AA603305 gb : np12d11. s1 NCl_CGAP_Pr3Homosapiens 5. 4 443756 AW089799 Hs. 153665 ESTs 5. 4 422232 D43945 Hs. 113274 Uanscription factor EC 5. 4 424574 BE408618 Hs. 150748 malonyl-CoA decarboxylase 5. 3 424834 AK001432 Hs. 153408 Homo sapiens cDNA FW 10570 fis, clone NT 5. 3 440589 BE397763 Hs. 194478 Homo sapiens mRNA ; cDNA DKFZp43401572 (f 5. 3 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 5. 3 450236 AW162998 Hs. 24684 KIAA1376 protein 5. 3 418110 R43523 Hs. 217754 HomosapienscDNA : FLJ22202 fis, clone H 5. 3 427061 AB032971 Hs. 173392 KIAAL 145 protein 5. 3 413841 M34276 Hs. 75576 plasminogen 5. 3 432358 A1093491 Hs. 72830 ESTs 5. 2 416805 F13271 Hs. 79981 Humanclone23560mRNAsequence 5. 2 438475 W03856 Hs. 13188 ESTs, Highly similar to Gene product wit 5. 2 443305 A1050693 Hs. 133318 ESTs 5. 2 413930 M86153 Hs. 75618 RAB11A, memberRASoncogenefamily 5. 1 451859 H44491 Hs. 252938 ESTs. Weakly similar to ALU 1 _HUMAN ALU S 5. 1 429826 N93266 Hs. 40747 ESTs 5. 1 436032 AA150797 Hs. 109276 latexin protein 5. 1

447081 Y13896 Hs. 17287 potassium inwardly-rectifying channel, s 5. 1 438297 AW515196 Hs. 258238 ESTs, Moderately similar to ALU1 HUMAN A 5. 1 421126 M74587 Hs. 102122 insulin-like growth factor binding prote 5. 1 440238 AW451970 Hs. 155644 paired box gene 2 5. 1 426651 AU076646 Hs. 171683 nuclear receptor subfamily 1, group H, m S. 0 425813 AA364136 Hs. 210553 ESTs, Weakly similar to hypothetical pro 5. 0 432328 Api572739 Hs. 195471 6-phosphofructo-2-kinaselfructose-2. 6-bi 5. 0 430682 AW971949 Hs. 291252 ESTs 5. 0 410049 AW579475 gb : RCO-DT0076-110100-031-10 DT006 Homo 5. 0 429222 A1457692 Hs. 99164 ESTs 5. 0 446317 A1287367 Hs. 150906 ESTs 5. 0 409506 NM006153 Hs. 54589 NCK adaptor protein 1 5. 0 407768 AW002841 Hs. 29475 ESTs 5. 0 437938 Api950087 gb : wq05c02. x1 NU_CGAP_Kidl2Homosapien 5, 0 430403 AF039390 Hs. 241382 tumor necrosis factor (ligand) superfami 4. 9 426215 AW963419 Hs. 155223 stanniocalcin 2 4. 9 448570 A1923944 Hs. 30913 ESTs 4. 9 445034 AW293376 Hs. 160323 ESTs 4. 9 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-4. 8 453891 AB037751 Hs. 36353 Homo sapiens mRNA full length insert cDN 4. 8 438492 AW340048 Hs. 293188 ESTs 4. 8 446417 AI299050 gb : qnl4dl2. xl NCI CGAP Lu5 Homo sapiens 4. 8 409578 BE041386 gb : hk88c02. xl NO CGAP_Lu21 Homosapiens 4. 8 447269 NM 004861 Hs. 17958 cerebroside (3'-phosphoadenylylsutfate : g 4. 8 413795 AL040178 Hs. 142003 ESTs 4. 8 422357 AF016272 Hs. 115418 cadherin 16, KSP-cadherin 4. 8 452208 AA024792 Hs. 31895 ESTs, WeaklysimilartoB9lH. sapiensj 4. 7 422711 D60641 Hs. 21739 Homo sapiens mRNA ; cDNA DKFZp58611518 (f 4. 7 441392 AW451831 Hs. 222119 ESTs, Weakly similar to K1CQHUMANKERAT 4. 7 439221 AA737106 Hs. 32250 ESTs 4. 7 431956 AK002032 Hs. 272245 Homo sapiens cDNA 170 fis. done PL 4. 7 417355 D13168 Hs. 82002 endothelin receptor type B 4. 7 414700 H63202 Hs. 38163 ESTs 4. 7 402739 4. 6 403170 4. 6 443486 NM003428 Hs. 9450 zinc finger protein 84 (HPF2) 4. 6 408380 AF123050 Hs. 44532 diubiquitin 4. 6 427899 AA829286 Hs. 181062 serum amybid A1 4. 5 446302 A1285848 Hs. 149757 ESTs 4. 5 414812 X72755 Hs. 77367 monokine induced by gamma interferon 4. 4 424063 NM 002019 Hs. 138671 fms-related tyrosine kinase 1 (vascular 4. 4 413384 NM0401 Hs. 75334 exostoses (multiple) 2 4. 4 421298 AW172431 Hs. 13012 ESTs 4. 4 420789 A1670057 Hs. 199882 ESTs 4. 4 453558 A1417023 Hs. 40478 ESTs 4. 4 453745 AA952989 Hs. 63908 Homo sapiens HSPC316 mRNA, partial cds 4. 4 451762 AF222980 Hs. 26985 disrupted in schizophrenia 1 4. 4 410334 AW979261 Hs. 291993 ESTs 4. 4 457030 Api301740 Hs. 173381 dihydropyrimidinase-like 2 4. 4 452194 A1694413 Hs. 298262 ESTs, Weakly similar to dJ88J8. 1 [H. sapi 4. 3 410407 X66839 Hs. 63287 carbonic anhydrase ! X 4. 3 401157 4. 3 432004 BE018302 Hs. 2894 placental growth factor, vascular endoth 4. 3 426866 U02330 Hs. 172816 neuregulin 1 4. 3 446115 A1733075 Hs. 292682 ESTs, Weakly similar to S69913 hypertens 4. 3 424704 A1263293 Hs. 152096 cytochrome P450, subfamily IIJ (arachido 4. 2 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponún, 4. 2 433578 BE336886 Hs. 3416 adipose differentiation-related protein 4. 2 407065 Y10141 gb : H. sapiens DAT1 gene, partial, VNTR. 4. 2 407182 AA312551 Hs. 230157 ESTs 4. 2 416565 AW000960 Hs. 44970 ESTs 4. 2 442230 BE219088 Hs. 279547 ESTs 4. 2 440680 AA903098 gb : ok46fO8. st NCI_CGAP_Lei2 Homo sapiens 4. 2 413802 AW964490 Hs. 32241 ESTs 4. 2 438370 AA843242 Hs. 48523 ESTs 4. 2 432731 R31178 Hs. 287820 fibronectin 1 4. 2 409745 AA077391 gb : 7B14E12 Chromosome 7 Fetal Brain CDNA 4. 2 441484 AA935481 Hs. 58972 ESTs 4. 2 411213 AA676939 Hs. 69285 neuropilin 1 4. 2 453045 AW418979 Hs. 224502 ESTs 4. 2 407999 A1126271 Hs. 49433 ESTs, Weakly similar to HYPOTHETICAL PRO 4. 2 409770 AW499536 gb : Ul-HF-BROp-aji-c-12-0-Ul. r1 NIH_MGC_5 4. 1 449856 AA203155 Hs. 18200 ESTs 4. 1 430806 S69377 Hs. 247978 T-llæuteiymphocyUcleukemia2 4. 1 412872 BE006341 gb : RC2-BN0127-240300-011-b05 BN0127 Homo 4. 1 430719 AA488988 Hs. 293796 ESTs 4. 1 409637 AA323948 Hs. 55407 Homo sapiens mRNA ; cDNADKFZp434K0621 (f 4. 1 414696 AF002020 Hs. 76918 Niemann-Pick disease, typed 4. 1 444670 H58373 Hs. 37494 ESTs 4. 1 448090 A1608821 Hs. 270289 ESTs 4. 1 408830 AK001709 Hs. 48403 hypothetical protein Fou 10847 4. 1 419088 Api538323 Hs. 77496 small nuclear ribonucleoprotein polypept 4. 1 416655 AW968613 Hs. 79428 BCL2/adenovinus E1B 19kD-interacUng pro 4. 1

436772 AW975688 Hs. 250867 zona pellucida glycoprotein 3A (sperm re 4. 1 442556 AL137761 Hs. 8379 Homo sapiens mRNA ; cDNA DKFZp586L2424 (f 4. 1 459595 AL040421 gb : DKFZp434B0714r1 434 (synonym : htes3) 4. 1 438859 Api559626 Hs. 164973 ESTs, Weakly similar to AF2310241 proto 4. 0 423279 AW959861 Hs. 290943 ESTs 4. 0 441592 AW137071 Hs. 127211 ESTs 4. 0 411836 AW901879 gb : QVO-NN1021-280400-212-ftO NN1021 Homo 4. 0 426384 Al472078 gb : tj85hO3. xl Soares_NSF_F8_9W_OT_PA_P_S 4. 0 412494 AL133900 Hs. 792 ADP-ribosylation factor domain protein 1 4. 0 413583 AL120806 Hs. 5888 ESTs 4. 0 415610 L44319 gb : HUMEST1D10 Human thymus NSTH II Homo 4. 0 430009 AA894564 Hs. 22242 ESTs 4. 0 449539 W80363 Hs. 58446 ESTs 4. 0 438929 AW195515 Hs. 253177 ESTs 4. 0 416000 R82342 Hs. 79856 ESTs 4. 0 429616 A1982722 Hs. 120845 ESTs 4. 0 458471 AV648609 Hs. 194240 ESTs 4. 0 453195 BE241876 Hs. 32352 hypotheticalprotein DKFZp434K1210 4. 0 459046 AA910339 Hs. 26216 Homo sapiens cDNA : FW22811fis, doneK 3. 9 438177 BE327015 Hs. 281391 ESTs 3. 9 422438 AA445925 Hs. 270896 ESTs 3. 9 450382 AA397658 Hs. 60257 Homo sapiens cDNA FW13598 fis, clone PL 3. 9 449611 A1970394 Hs. 197075 ESTs 3. 9 452030 AL137578 Hs. 27607 Homo sapiens mRNA ; cDNA DKFZpS64N2464 ( 3. 9 452881 AW135220 Hs. 241921 ESTs 3. 9 414729 BE466928 Hs. 281901 ESTs 3. 9 428816 AA004986 Hs. 193852 ATP-binding cassette, sub-family C (CFTR 3. 9 405908 3. 8 445452 H92975 Hs. 246046 ESTs, Weakly similar to RET1_HUMAN RETIN 3. 8 447961 W32791 Hs. 170405 ESTs 3. 8 446639 A1016826 Hs. 132501 ESTs 3. 8 401189 3. 8 429548 AW138872 Hs. 135288 ESTs 3. 8 431523 N55759 Hs. 163674 ESTs 3. 8 430014 H59354 Hs. 182485 actinin, alpha 4 3. 8 429250 H56585 Hs. 198308 tryptophan rich basic protein 3. 8 451988 AF263928 Hs. 27410 papillomavirus regulatory factor PRF-1 3. 8 437939 AW298600 Hs. 141840 ESTs, Weakly similar to S59501 interfere 3. 8 427510 Z47542 Hs. 179312 small nuclear RNA activaGng complex, po 3. 8 433522 A1821730 Hs. 116524 ESTs 3. 8 443843 AW878864 Hs. 13528 Homo sapiens cDNA FLJ 14054 fis, clone HE 3. 7 407305 AA715284 gb : nv35fO3. rl NCl_CGAP_BrSHomosapiens 3. 7 434613 At821826 Hs. 187786 ESTs, Moderately similar to ALUBHUMAN ! 3. 7 410276 A1554545 Hs. 68301 ESTs 3. 7 422504 AA311407 gb : EST1821 67 Jurkat T cells V Homo sapie 3. 7 421013 M62397 Hs. 1345 mutated in colorectal cancers 3. 7 437949 U78519 Hs. 41654 ESTs 3. 7 431840 AA534908 Hs. 2860 POU domain, class 5, transcription facto 3. 7 409446 A1561173 Hs. 67688 ESTs 3. 7 415263 AA948033 Hs. 130853 ESTs 3. 7 450206 A1796450 Hs. 201600 ESTs 3. 7 439444 A1277652 Hs. 54578 ESTs 3. 7 437828 AW976806 Hs. 291805 ESTs 3. 7 453238 AA033991 Hs. 269234 ESTs 3. 7 420041 AB005142 Hs. 94592 klotho 3. 7 448458 AW614367 Hs. 171054 ESTs 3. 7 435080 A1831760 Hs. 155111 ESTs 3. 7 444249 T87398 Hs. 205816 ESTs 3. 7 426595 AW971980 Hs. 62402 p21 ; Cdc42/Rac1-activatedkinaset (yeast 3. 7 417715 AW969587 Hs. 86366 ESTs 3. 7 432579 AF043244 Hs. 278439 nucleolar protein 3 (apoptosis repressor 3. 6 440048 AA897461 Hs. 158469 ESTs, Weakly similar to envelope protein 3. 6 430091 AB032958 Hs. 233023 KIAA1132 protein 3. 6 438030 X98427 Hs. 122634 ESTs 3. 6 453496 AA442103 Hs. 33084 solute carrier family 2 (facilitated glu 3. 6 446636 AC002563 Hs. 15767 citron (rho-interacting, serine/threonin 3. 6 417860 AW408557 Hs. 235498 Homo sapiens cDNA FU14075 fis, clone HE 3. 6 435794 H72108 Hs. 13704 ESTs 3. 6 449695 AA164569 Hs. 34550 ESTs 3. 6 411485 AW848125 gb : L3-CT0214-301299-048-G04CT0214Homo 3. 6 426274 D38122 Hs. 2007 tumor necrosis factor (ligand) superfami 3. 6 458201 Al989961 Hs. 233477 ESTs, Moderately similar to A Chain A, S 3. 6 440987 AA911705 Hs. 130229 ESTs 3. 6 425178 H16097 Hs. 161027 ESTs 3. 6 419080 AW150835 Hs. 18878 hypothetical protein FLJ21620 3. 6 436091 AA704705 Hs. 181044 ESTs, Weakly similar to A Chain A, Human 3. 6 452671 AW861074 Hs. 225833 ESTs 3. 6 437222 AL117588 Hs. 299963 ESTs 3. 6 437809 AL137723 Hs. 5855 Homo sapiens mRNA ; cDNADKFZp434D0818 (f 35 411545 AW850818 gb : IL3-CT0220-091199-026-A03 CT0220 Homo 3. 5 414799 Api752416 Hs. 77326 insulin-like growth factor binding prote 3. 5 439882 AA847856 Hs. 124565 ESTs 3. 5 419229 A1827237 Hs. 282884 ESTs 3. 5

431889 AA521277 Hs. 124946 ESTs 3. 5 422660 AW297582 Hs. 237062 ESTs 3. 5 415122 D60708 Hs. 22245 ESTs 35 444127 N63620 Hs. 13281 ESTs 3. 5 416913 AW934714 gb : RC1-DT0001-031299 011-all DT0001 Homo 3. 5 409044 A1129586 Hs. 33033 ESTs 3. 5 453365 AA035211 Hs. 17404 ESTs 3. 5 452355 N54926 Hs. 29202 G protein-coupled receptor 34 3. 5 423246 AL119114 Hs. 23107 ESTs 35 434131 A1858275 Hs. 143659 ESTs 3. 5 425304 AA463844 Hs. 31339 fibroNastgrowthfactor11 15 453775 NM_002916 Hs. 35120 replication factor C (activator 1) 4 (37 3. 4 426559 AB001914 Hs. 170414 paired basic amino acid cleaving system 3. 4 456311 AA225632 Hs. 190016 ESTs 3. 4 420737 L08096 Hs. 99899 tumor necrosis factor (ligand) superfami 3. 4 448733 NM_005629 Hs. 187958 soluiecamerfamily6 (neurotransmilte 3. 4 401811 3'4 404021 3 4 447175 A1365208 Hs. 293606 ESTs 3. 4 453743 AL120480 gb : DKFZp761KO98-rl 761 (synonym : hamy2) 3. 4 455070 AW854675 gb : MR1-CT0258-290300-206-aO1 CT0258 Homo 3. 4 419546 AA244199 gb : ncO6cO5. s1 NO_CGAP_Pr1 Homosapiens 3. 4 449441 A1656040 Hs. 196532 ESTs 3. 4 441606 R37263 Hs. 21065 ESTs 3. 4 446594 A1311917 Hs. 16292 ESTs 3. 4 424664 A1432572 Hs. 164221 ESTs 3. 4 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy 3. 4 427914 AA417350 Hs. 20575 ESTs 3. 4 438257 AW474419 Hs. 224794 ESTs 3. 4 412642 BE244598 Hs. 809 hepatocyte growth factor (hepapoietin A ; 3. 4 454690 AW854639 gb : MR1-CT0258-140100-203410 CT0258 Homo 3. 3 428046 AW812795 Hs. 155381 ESTs, Moderately similar to 38022 hypot 3. 3 407331 A1570416 Hs. 99910 phosphofructokinase, platelet 3. 3 440472 AA886169 Hs. 169071 ESTs 3. 3 421893 NM_001078 Hs. 109225 vascular cell adhesion molecule 1 3. 3 403797 3. 3 417924 AU077231 Hs. 82932 cyclin D1 (PRAD1 : parathyroid adenomatos 3. 3 410623 AW958932 Hs. 293833 ESTs 3. 3 449338 H73444 Hs. 394 adrenomedullin 13 441024 AW081530 Hs. 137088 ESTs 3. 3 405257 3. 3 450396 AU077002 Hs. 24950 regulator of G-protein signalling 5 3. 3 416892 L24498 Hs. 80409 growth arrest and DNA-damage-inducibie. 13 444471 AB020684 Hs. 11217 KIAA0877 protein 3. 3 431689 AA305688 Hs. 267695 UDP-Gal : betaGIcNAc beta 1, 3-galactosyltr 3. 3 452093 AA447453 Hs. 27860 Homo sapiens mRNA ; cDNA DKFZp586M0723 (f 3. 3 425236 AW067800 Hs. 155223 stanniocalcin 2 3. 3 428824 W23624 Hs. 173059 ESTs 3. 2 450101 AV649989 Hs. 24385 Human hbc647mRNA sequence 3. 2 425260 L47726 Hs. 1870 phenylalanine hydroxylase 3. 2 443830 A1142095 Hs. 143273 ESTs 3. 2 415245 N59650 Hs. 27252 ESTs 3. 2 405953 3. 2 430812 L10405 Hs. 247992 DNA binding protein for surfactant prote 3. 2 418946 A1798841 Hs. 132103 ESTs 3. 2 424750 D29956 Hs. 152818 ubiquifin specific protease 8 3. 2 435342 AW979168 Hs. 163270 ESTs 3. 2 458860 AW873557 Hs. 212739 ESTs 3. 2 430172 AA468591 Hs. 161889 ESTs 3. 2 431842 NM005764 Hs. 271473 epithelial protein up-regulated in carci 3. 2 451221 A1949701 Hs. 210589 ESTs 3. 2 436211 AK001581 Hs. 80961 polymerase (DNA directed), gamma 3. 2 433727 C16221 Hs. 112608 ESTs 3. 2 424897 D63216 Hs. 153684 frizzled-related protein 3. 2 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 3. 1 418030 BE207573 Hs. 83321 neuromedin B 3. 1 417919 A1928203 Hs. 86379 ESTs 3. 1 430437 AI768801 Hs. 169943 Homo sapiens cDNA FLJ13569 fis, clone PL 3. 1 409663 A1743750 Hs. 65862 ESTs 3. 1 454024 AA993527 Hs. 16281 hypothetical protein FLJ23403 3. 1 424980 L42172 Hs. 154078 lipopolysaccharide-binding protein 3. 1 421633 AF121860 Hs. 106260 sorting nexin 10 3. 1 436002 R68529 Hs. 120967 ESTs 3. 1 437682 AA476652 Hs. 94952 Homo sapiens cDNA : FLJ23371 fis, clone H 3. 1 439451 AF086270 Hs. 278554 heterochromatin-like protein 1 3. 1 430183 BE010038 gb : PM3-BN0176-100400-001-g04BN0176Homo 3. 1 428479 Y00272 Hs. 184572 cell division cycle 2, G1 to S and G2 to 3. 1 441285 NM 002374 Hs. 167 microtubule-associated protein 2 3. 1 456386 W28481 gb : 47e1 Human reGna cDNA randomly prime 3. 1 451130 A1762250 Hs. 211347 ESTs 3. 1 439702 AW085525 Hs. 134182 ESTs 3. 1 453331 A1240665 Hs. 8895 ESTs 3. 1 428841 A1418430 Hs. 104935 ESTs 31

449899 A1610700 Hs. 103280 ESTs 3. 1 436009 H57130 Hs. 120925 ESTs 3. 1 448966 AW372914 Hs. 287462 Homo sapiens CDNA FU 11875 fis, clone HE 3. 1 408239 AA053401 Hs. 271827 ESTs, Moderately similar to ALU7 HUMAN A 3. 1 418526 BE019020 Hs. 85838 solute carrier family 16 (monocarboxytic 3. 1 401260 3. 1 450705 U90304 Hs. 25351 iroquois-dass homeodomain protein 3. 1 447233 AW246333 Hs. 17901 Homo sapiens cDNA : FW21974 fis, clone H 3. 1 424415 Nom001975 Hs. 146580 enolase 2, (gamma, neuronal) 3. 0 403346 3. 0 446319 AW207590 Hs. 160711 ESTs 3. 0 432757 AF113013 Hs. 278919 PROO806 protein 3. 0 407921 A1378617 Hs. 23100 Homo sapiens CDNA FU 12592 fis, clone NT 3. 0 414618 Api204600 Hs. 96978 ESTs 3. 0 434398 AA121098 Hs. 3838 serum-inducible kinase 3. 0 440113 A1916532 Hs. 188272 ESTs 3. 0 424539 L02911 Hs. 150402 æGvinArecepior, qpel 3. 0 428945 AW192803 Hs. 98974 ESTs 3. 0 458297 R54033 Hs. 21245 ESTs 3. 0 424405 A1076838 Hs. 12967 ESTs 3. 0 411290 AW835544 gb : QV4-LT0016-271299-068-f03 LT0016 Homo 3. 0 459068 BE464396 Hs. 118468 ESTs 3. 0 459065 A1373532 Hs. 157910 ESTs 3. 0 437693 A1754443 Hs. 185951 ESTs 3. 0 429418 A1381028 Hs. 99283 ESTs 3. 0 406117 3. 0 415492 R41674 Hs. 16491 ESTs 3. 0 419854 AW664873 Hs. 87836 Homo sapiens PAC clone RP5-1087M19 from 3. 0 453688 AW381270 Hs. 194110 Homo sapiens mRNA ; cDNADKFZp434C0814 (f 3. 0 408119 W26213 gb : 22d 10 Human retina cDNA randomly prim 3. 0 438358 AL035992 Hs. 210278 ESTs 3. 0 412372 R65998 Hs. 118615 ESTs 3. 0 431984 AL080239 Hs. 272284 Human DNA sequence from clone GS1-256022 3. 0 403782 3. 0 443183 R16258 Hs. 6217 Homo sapiens cDNA FU 12521 fis, clone NT 3. 0 456388 W28557 gb : 48d8 Human retina cDNA randomly prime 3. 0 447922 Z92910 Hs. 20019 hemochromatosis 3. 0 428857 AF008192 Hs. 194283 putative GR6 protein 3. 0 406991 S82185 (NONE) 3. 0 432596 AJ224741 Hs. 278461 matrilin 3 3. 0 453202 AW085781 Hs. 26270 HomosapienscDNAFW11588fis, cloneHE 3. 0 414132 A1801235 Hs. 48480 ESTs 3. 0 409122 W07089 Hs. 297873 ESTs 3. 0 405547 3. 0 422219 AW978073 gb : EST390182 MAGE resequences, MAGO Homo 3. 0 417227 T57776 Hs. 191094 ESTs 3. 0 448592 N69546 Hs. 141706 ESTs 3. 0 421477 A1904743 Hs. 104650 hypothetical protein FU10292 3. 0 400368 BE779978 Hs. 69149 pnoline-serine-threonine phosphatae int 3. 0 455362 AW902635 gb : QV3-NN1024-100500-181-bO2 NN1024 Homo 3. 0 443578 R97191 Hs. 134106 ESTs 3. 0 419348 AA236645 Hs. 98274 ESTs 3. 0 439138 A1742605 Hs. 193696 ESTs 3. 0 449547 H93543 Hs. 117963 ESTs 3. 0 455180 AW863503 gb : MR3SN0009-180400-110-c12SN0009Homo 3. 0 444228 AV648612 Hs. 282396 ESTs 3. 0 423496 U91963 Hs. 129700 tolloid-like 1 3. 0 401707 3. 0 419276 BE165909 Hs. 134682 Homo sapiens cDNA : FLJ23161 fis, clone L 3. 0 441677 AW271702 Hs. 93739 ESTs 3. 0 459587 AA031956 gb : zk15e04. sl Soarespregnantuterus NbH 3. 0 431311 AA502552 Hs. 188980 ESTs 3. 0 426326 BE165753 Hs. 250528 ESTs, Weakly similar to unnamed protein 3. 0 412685 BE092186 gb : IL2-BT0734-200400-075-H05 BT0734 Homo 3. 0 414752 BE503505 Hs. 248689 ESTs 3. 0 403144 3 0 407539 X91103 gb : H. sapiens mRNA for Hr44 protein. 3. 0 412379 AW947581 gb : RCO-MT0004-140300-031-dO8 MT0004 Homo 3. 0 407937 AW297944 Hs. 242811 ESTs 3. 0 456976 A1681882 Hs. 270428 ESTs 3. 0 417066 AA329572 Hs. 172004 bOn 3. 0 406007 3. 0 416940 N75620 Hs. 43157 ESTs 3. 0 433322 H50621 Hs. 134156 ESTs 3. 0 406088 3. 0 416573 R10356 Hs. 18865 ESTs, Weakly similar to AC007228 2 BC372 3. 0 423130 AW897586 Hs. 21213 ESTs 3. 0 412721 AW183165 Hs. 95600 ESTs 3. 0 418375 NM003081 Hs. 84389 synaptosomal-associated protein, 25kD 3. 0 422992 AF016833 Hs. 122785 maltase-glucoamylase (alpha-glucosidase) 3. 0 406506 3. 0 413472 BE242870 Hs. 75379 solute carrier family 1 (glial high affi 3. 0 422650 D42055 Hs. 1565 neural precursor cell expressed, develop 3. 0

400325 M85292 Hs. 247924 Homo sapiens endogenous HIV-1 related se 3. 0 401078 3. 0 446645 A1336596 Hs. 156294 ESTs 30 446704 A1337228 Hs. 197083 ESTs 3. 0 427072 H38046 gb : ypS8c10. r1 Soares fetal liver spleen 3. 0 TABLE 338 : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 407615 1005404_1 AW753085 AW753082 AW054744 AW753107 AW753087 408119 1040172_1 W26213 H08055 Z44031 AW954559 R17434 409519 113722 1 AA075368 AA075369 409578 1140976_1 BE041386 AW419449 AW663595 409594 1142491 AA076118AA975618AA076220 409695 114876 1 AA296961 AA296889 AA076945 AA077528 AA077497 409745 115237 1 AA077391 AI347618 AI361453 A1088754 AW207491 AW960912 AA921874 AA286833 AA150722 BE152353 AW788822 BE152450 409770 1154048_1 AW499536 AW499553 AW502138 AW499537 AW502136 AW501743 410008 116812_1 M079552 BE142525 BE142527 410049 1172307_1 AW579475 AW939654 AW939655 410534 1207247 1 AW905138AW753008R13818Z43519 410754 1219733 1 T63840AW801569AW801568 411290 1237738J AW835544 AW835613 AW835711 AW835697 AW835703 BE092535 BE092199 4114851247181JAW848125 AW848124 AW848203 AW848695 AW848633 AW848693 BE350771 411545 1249138 1 AW850818 AW850833 AW851100 411836 1260619_1 AW901879 AW901875 AW866247 BE011294 BE504813 412209 1283610_1 AW901456AW901450AW901441 412359 129085_1 AW637985 AW837938 M101955 AW837913 AW837935 412379 1292479_1 AW947581 AW947546AW947545AW947544 412685 1321663_1 BE092186BE092157AW983859 412872 1333898-1 BE006341 BE006307 BE006311 413070 134815 1 AA126776 AA133984 BE148613 BE063475 AA358219 415610 1540554 1 L44319 F12851 T75057 415713 154859 1 AW968573 AAi 67225 AA491129 416462 1595954 1 W92845 H57479 416548 1600181_1 H62953 N76608 N72413 416913 163001 1 AW934714 BE16t007 BE162500 AW749902 AW749864 BEi62498 BE161005 AA190449 AW513465 BE161006 BE162499 417038 164390_1 T85230M192508T89190 418053 171810 1 M211493AW817839AW817836 419213 182860 1 AW749146 AW749138 AW749123 AW749130 AA235142 419546 i85766 1 AA244199 AA244272 H57440 420637 195241_1 AW976153 AA278945 AA747691 422063 210852_1 BE156476 BE156473 BE156474 BE156475 M302839 422219 213547 1 AW978073AW976072M807550M306567 422504 217160 1 AA311407 AW958321 N23583 R70050 423735 231498J AA330259AA661806AA502431AW974633AA649496 426384 266211 1 A1472078 AA377209 AA865807 427072 274884_1 H38046 W69645 AA397968 H38047 428637 2936601 AW979268AA878419AA431342AA431628 430183 314122 BE010038 AA676833 A1311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 AI936370 AA552514 T67280 AA039909 431595 335512 1 AA508196 BE142920 A1280311 A1205616 D61709 432009 34025 1 AL137424 BE007148 T52277 437205 43463-1 ALl 10232 N94765 437938 44573 2 AI950087 N70208 R97040 N36809 Al308119 AW967677 N35320 Al251473 H59397 AW971573 R97278 W01059 AW967671 AA908598 AA251875 Ai820501 Api820532 W87891 T85904 U71456 T82391 BE328571 T75102 R34725 AA884922 BE328517 Al219788 M884444 N92578 F13493 AA927794 Api560251 AW874068 AL134043 AW235363 AA663345 AW008282 AA488964 AA283144 AI890387 AI950344 AI741346 AI689062 AA282915 AW 102898 AI872193 AI763273 AW173586 AW150329 AI653832 A1762688 AA988777 AA488892 AI356394 AW103813 M539642 AA642789 AA856975 AW505512 AI961530 AW629970 BE612881 AW276997 AW513601 AW512843 AA044209 AW856538 AA180009 AA337499 AW961101 AA251669 AA251874 Api819225 AW205862 AI683338 A1858509 AW276905 AI633006 AA972584 AA908741 AW072629 AW513996 AA293273 AA969759 N75628 N22388 H84729 H60052 T92487 A1022058 AA780419 AA551005 W80701 AW613456 AI373032 AI564269 F00531 H83488 W37181 W78802 R66056 A1002839 R67840 AA300207 AW959581 T63226 F04005 438966 467436 1 AW979074 AA834841 AA828650 438993 4676511 AA828995AA834879A) 926361 440680 500121 1 AA903098 AW836693 BE160824 AW606818 AW582699 AW836766 442438 542469-1 AA995998 A1916584 R61781 T77332 F07756 F08149 F07647 446346 673545_1 A1290205AW235762A1651268 446417 676384_1 Al299050BE256910 447641 73043_1 BE619186 BE264952 R26042 448450 76399 1 BE612490 T05205 AA481187 449034 794317_1 Al624049AW117770AI858360 450625 84032_1 AW970107 AA513951 AA010406 452453 918300 1 AI902519 AI902518 AI902516 453743 979613 1 AL120480 AW836448 AW176802 453955 989877 1 AW579207 AW936883 AW008026 N88905 454392 115882 1 BE260893 AA078319 R85057 AW803024 H85811 AA078293 454490 1217172_1 AW797778AW797781 AW797780 454690 1229106-1 AW854639 AW854719 AW854718 BE145880 AW854692 BE145866 AW816154 AW854698 AW854654 AW813335 AW854699 454933 1245515_1 BE141714AW845993AW845989 455070 1252209_1 AW854675 AW854685 AW854716 AW854690 AW854615 AW854624 AW854623 AW854641 AW854632 AW854695 AW854661 455180 1258658 1 AW863503 AW863362 455275 1272255_1 AW977806AW887923AW886321

455362 1284507J AW902635AW902574BE011167BE011329AW902808AW902651 455711 1352369 1 BE069465 BE069505 456386 1842693-1 W28481 456388 1842839-1 W28557 456411 185688 1 AA603305 AA244095 AA244183 459587 948931 AA031956 459595 969956_1 AL040421 TABLE 33C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, el al.'refers to the publication enGUed'The DNA sequence of human chromosome 22-Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 401078 3687273 Plus 105052-105171 401157 9438289 Minus 114133-114247, 114567-114645 401189 9690246 Minus 90815-90929 401260 8076883 Minus 86008-86355 401352 9931258 Minus 26064-26208 401439 8246737 Plus 92993-94026 401707 2951946 Plus 21972-22104 401811 6730720 Plus 107002-107209 401976 3095020 Minus 17594-17709. 21068-21175 402045 7923943 Plus 5964-6128 402421 9796341 Minus 4660go662, 46758-46811, 86293-86346, 89776-89829, 9004890101, 102817-102924 402696 7328818 Minus 23600-23731 402739 9212192 Plus 60456-61019 402921 7981303 Minus 52242-52384, 555955858, 57124-57309, 59633-59761, 59957-60123 403095 8954339 Plus 150025-150240, 151564-151690 403111 8980970 Plus 175012-175159 403144 9454649 Minus 166200-166628 403170 9838134 Plus 40955-41356 403345 8569726 Plus 77890-78069 403346 8569726 Plus 92752-93015 403563 8101139 Plus 2800-3501 403622 8569879 Plus 1941-2388, 2580-2761 403782 8078608 Plus 41326-41633 403797 8099896 Minus 123065-125008 403899 7381715 Minus 9144-9350 404021 8655966 Plus 192534-193489 404115 9621489 Plus 232707-232982 404200 6010176 Minus 7066-7210 404347 9838195 Plus 74493-74829 404939 6862697 Plus 17531&175476 405257 7329310 Plus 73121-73273 405336 6094635 Plus 33267-33563 405394 6624123 Minus 31900-32373 405547 1054740 Plus 124361-124520, 124914-125050 405609 5757553 Minus 42814-43010, 43583-43783, 44863-45033, 4642946554, 47815-48018, 49961-50153, 51624-51727, 51823-51959, 52702-52918, 55469- 55601, 57111-57307, 58160, 58296, 60215-60332, 61482-61727 405908 6758795 Plus 97969-98715 405943 6758796 Plus 20605-20812 405953 7960374 Minus 65101-65574 405963 8247786 Plus 4056-4699 406007 8247802 Minus 13484-13829 406030 8312328 Minus 96123-96547 406088 9123919 Minus 65772-66270 406117 9142932 Plus 54304-54584 406242 7417725 Minus 36736-36951 406291 5686274 Plus 9562-9867 406411 9256407 Plus 7400-7527 406414 9256407 Plus 49593-49850 406504 7711360 Minus 107068-107277 406506 7711374 Minus 6843-8077 406598 8248614 Plus 56373-56849 TABLE 34A : ABOUT 197 GENES UP-REGULATED IN KIDNEY CANCER Table 34A lists about 197 genes up-regulated in kidney cancer compared to normal adult tissues that are likely to be extracellular or cell-surface proteins. These were selected as for Table 33A and the predicted protein contained a structural domain that is indicative of extracellular localization (e. g. ig, fn3, egf, 7tm domains). Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD. Unigene number Unigene Title : Unigene gene title PSDomain : Protein Structural Domain R1 : Ratio of tumor to normal tissue Pkey ExAccn UnigenelD UnigeneTitle PSDomain R1 421471 U90545 Hs. 104635 solute carrier TM, SS 1007. 4 452401 NM_007115 Hs. 29352 tumornecrosis TM, SS, Xlink, CUB 336. 4 421727 Y13153 Hs. 107318 kynurenine 3-mo TM, SS, Monooxygenase 323. 6

426471 M22440 Hs. 170009 transforming gr TM, SS, EGF 224. 6 441031 Al110684 Hs. 7645 fibrinogen, B b fibrinogen_C 174. 0 411642 NM014932 Hs. 71132 neuroligin 1 TM, SS, COesterase 172. 4 452838 U65011 Hs. 30743 preferentially TM 161. 4 425984 AW836277 Hs. 165636 hypothetcal pr TM 151. 0 453165 S74727 Hs. 32042 aspartoacylase TM 134. 8 452431 U88879 Hs. 29499 toll-like recep TM, SS, TIRLRRCT 130. 6 423508 AW604297 Hs. 129711 hepatitisAvir TM, SS, ig 120. 4 407975 X89426 Hs. 41716 endothelial cel SS, IGFBP 111. 8 415076 NM_000857 Hs. 77890 guanylate cycla TM, guanylate-cyc 97. 0 447046 AA326187 Hs. 17170 G protein-coupl TM, 7tm_1 90. 2 423109 M59305 Hs. 123655 natriuretic pep TM, SS, ANF receptor 78. 0 422544 AB018259 Hs. 118140 KIAA0716 gene p TM 74. 8 429352 AK001512 Hs. 200097 hypothetical pr TM 73. 0 453392 U23752 Hs. 32964 SRY (sex detertn TM, HMG box 72. 2 403345 TM, alpha-amylase 69. 6 430440 X52599 Hs. 2561 nerve growth fa TM, SS, NGF 69. 0 408609 AA330431 Hs. 640 calcitonin rece TM, SS, 7tm 2 57. 4 449101 AA205847 Hs. 23016 G protein-coupl TM, 7im_1 52. 0 423685 BE350494 Hs. 49753 Homo sapiens mR TM, Myosin_tail 48. 0 452891 N75582 Hs. 212875 ESTs, Weakly si SS 44. 0 408430 S79876 Hs. 44926 dipeptidylpepti TM, SS, DPPIV_N_temm, PepGdase_S9 42. 6 419287 X91906 Hs. 89872 chloride channe TM, CBS, voltage_CLC 40. 6 428822 W28418 Hs. 301148 potassium volta TM 40. 2 434208 T92641 Hs. 127648 hypothetical pr TM, SS 39. 2 400792 AA635062 Hs. 50094 Homo sapiens mR TM, BIRCARD, zf-C3HC4 38. 6 444743 AA045648 Hs. 11817 nudix (nucleosi TM, mutT 38. 4 406411 TM, vwa, FG-GAP 37. 6 423657 AL045128 Hs. 1691 glucan (1, 4-alp TM, alpha-amylase 37. 5 424871 Nom004525 Hs. 153595 bwdensiqlip TM, SS, EGF, idl_recept_a, ldi_recepi_b 32. 8 449625 NM 014253 Hs. 23796 odz (odd Ozlten SH2, EGF 30. 5 423020 AA383092 Hs. 1608 replication pro TM 29. 6 422420 U03398 Hs. 1524 tumor necrosis TM, TNF 29. 6 414245 BE148072 Hs. 75850 WAS protein fam TM, WH2 28. 8 410247 AF181721 Hs. 61345 RU2S TM 27. 4 406414 TM, vwa, FG-GAP 27. 2 435951 AF269162 Hs. 41267 c21orf7formA-TM 27. 2 419948 AB041035 Hs. 93847 NADPH oxidase 4 TM, SS, Ferric_reduct 26. 4 448595 AB014544 Hs. 21572 KIAA0644 gene p TM, SS, LRRCT, LRR 25. 8 419569 Api971651 Hs. 91143 jagged 1 (Alagi TM, SS, DSL, EGF 25. 6 433242 AB040938 Hs. 113940 KIAA1505 protei SS 25. 6 416778 M16505 Hs. 79876 steroid sulfata TM, Sulfatae 23. 0 401352 TM 22. 6 404200 SS 19. 6 446591 H44186 Hs. 15456 PDZ domain cont TM, PDZ 19. 2 431806 AF186114 Hs. 270737 tumor necrosis TM. SS 18. 0 423909 AJ223183 Hs. 135194 immunoglobulin TM, SS, ig 17. 6 446364 AB006624 Hs. 14912 KIAA0286 protei TM 17. 4 425695 NM_005401 Hs. 159238 protein tyrosin TM, Band_41, Y-phosphatase 17. 0 410947 AK000305 Hs. 67055 hypothetical pr TM 16. 8 421002 AF116030 Hs. 100932 transcription f TM, KRAB, zf-C2H2 16. 5 421659 NM 014459 Hs. 106511 protocadhehn 1 TM, SS, cadhedn 16. 0 458679 AW975460 Hs. 143563 ESTs SS 14. 4 406598 SS 13. 6 428508 BE252383 Hs. 184668 SBB131 protein TM, PX 13. 2 423321 AB013885 Hs. 126926 beta-ureidoprop TM, SS, CN_hydrolase 12. 5 422317 NM001147 Hs. 115181 angiopoietin 2 fibnnogen_C 12. 2 428227 AA321649 Hs. 2248 small inducible IL8 12. 0 414923 AW445008 Hs. 77637 homeo box A4 TM, homeobox 11. 9 433231 AB040926 Hs. 143552 KIAA1493 protei SS 11. 6 443672 AA323362 Hs. 9667 butyrobetaine (TM 11. 4 405609 TM, Myosin tail, myosin_head 11. 4 418912 NM 000685 Hs. 89472 angiotensin rec TM, 7tm1 11. 4 449802 AW901804 Hs. 23984 hypothetical pr TM 11. 2 404347 SS 10. 8 429945 NM_006729 Hs. 226483 diaphanous (Dro TM, FH2 10. 6 435085 AW130284 Hs. 192752 ESTs, Moderate TM 10. 6 404115 SS 10. 2 420757 X78592 Hs. 99915 androgenrecept TM. Androgenrecep. hormonerec. zf-C4 10. 2 446298 AF187813 Hs. 14637 kidney-and liv TM, Acetyltransf 10. 1 433703 AA210863 Hs. 3532 nemo-like kinas TM, pkinase 9. 2 417404 NM 007350 Hs. 82101 pleckstnnhomo TM 9. 2 451621 Api879148 Hs. 26770 fatty acid bind TM, SS, lipocalin 9. 2 402045 TM, SS 9. 0 403095 SS, PAX, homeobox 8. 8 401439 TM 8. 6 407721 Y12735 Hs. 38018 dual-specificit TM, pkinase 8. 4 402921 TM 8. 4 419503 AA243642 Hs. 137422 ESTs TM 8. 4 452259 AA317439 Hs. 28707 signal sequence TM 8. 4 402696 TM 8. 3 450001 NM001044 Hs. 406 solute carrier TM, SS, SNF 8. 1 433190 M26901 Hs. 3210 renin SS, asp 7. 8

449444 AW818436 Hs. 23590 solute carrier TM, MCT 7. 7 444042 NM004915 Hs. 10237 ATP-bindingca TM, ABC tran 77 452883 X80031 Hs. 150318 ESTs TM, C4, Collagen 7. 4 425151 AA351814 Hs. 298678 ESTs TM 7. 2 455068 Api807894 Hs. 27910 centrosomal pro TM, SS 7. 2 406504 TM 7. 2 410274 AA381807 Hs. 61762 hypoxia-inducib SS 7. 0 423349 AF010258 Hs. 127428 homeo box A9 TM, homeobox 6. 8 408771 AW732573 Hs. 47584 potassium volta TM, K_tetra, ion_trans 6. 8 445575 Z25368 Hs. 172004 fitin TM 6. 6 415138 C18356 Hs. 78045 tissue factor p Kunitz BPTI, G-gamma 6. 3 443595 AF169312 Hs. 9613 PPAR (gamma) ang TM, SS, fibrinogen_C 6. 3 404939 TM 6. 3 436209 AW850417 Hs. 254020 ESTs, Moderatel TM, SS 6. 2 403111 TM 6. 2 405394 TM 6. 0 454392 BE260893 gb : 601150677F1 TM, SS 6. 0 415910 U20350 Hs. 78913 chemokine (C-X3 TM, 7tm1 5. 9 402421 TM 5. 8 425717 X07282 Hs. 171495 refinoic acid r TM, hormone_rec, zf-C4 5. 7 427920 Z11502 Hs. 181107 annexinA13 TM, annexin 5. 6 407864 AF069291 Hs. 40539 chromosome 8 op TM, FHA, BRCT 5. 5 441006 AW605267 Hs. 7627 CGI-60 protein TM 5. 4 422232 D43945 Hs. 113274 transcriptionf TM, HLH 5. 4 425782 U66468 Hs. 159525 cell growth reg SS 5. 3 450236 AW162998 Hs. 24684 KtAA1376 protei TM, SS 5. 3 413841 M34276 Hs. 75576 plasminogen SS, trypsin, kringle, PAN 5. 3 436032 AA150797 Hs. 109276 latexin protein TM 5. 1 447081 Y13896 Hs. 17287 potassium inwar TM, IRK 5. 1 421126 M74587 Hs. 102122 insulin-like gr SS, thyroglobulin_i, IGFBP 5. 1 426651 AU076646 Hs. 171683 nuclear recepto TM, zf-C4, hormone_rec 5. 0 432328 Api572739 Hs. 195471 6-phosphofruc (o TM, 6PF2K, PGAM 5. 0 409506 NM006153 Hs. 54589 NCK adaptor pro TM, SH2, SH3 5. 0 410361 BE391804 Hs. 62661 guanylate bindi TM, SS, GBP 4. 8 453891 AB037751 Hs. 36353 Homo sapiens mR TM 4. 8 447269 NM 004861 Hs. 17958 cerebroside (3 TM, SS 4. 8 422357 AF016272 Hs. 115418 cadhenn 16, KS TM, cadherin 4. 8 417355 D13168 Hs. 82002 endothelin re TM, SS, 7tm_1, zf-C3HC4 4. 7 402739 SS 4. 6 443486 NM003428 Hs. 9450 zinc finger pro TM, KRAB, zf-C2H2 4. 6 408380 AF123050 Hs. 44532 diubiquitin TM, ubiquitin, 7tm_3, ANF receptor, sushi, 7tm1 4. 6 414812 X72755 Hs. 77367 monokine induce SS. 1L8 4. 4 424063 NM002019 Hs. 138671 fms-related tyr TM, SS, pkinase, ig 4. 4 413384 NM_000401 Hs. 75334 exostoses (mult TM 4. 4 457030 Api301740 Hs. 173381 dihydropyrimidi TM, SS, Dihydroorotase 4. 4 410407 X66839 Hs. 63287 carbonic anhydr TM, SS, carb-anhydrase 4. 3 401157 TM, citrate_synt 4. 3 432004 BE018302 Hs. 2894 placenta growt SS, PDGF 4. 3 424704 A1263293 Hs. 152096 cytochrome P450 SS, p450 4. 2 407065 Y10141 gb : H. sapiens DA TM, SS, SNF 4. 2 411213 AA676939 Hs. 69285 neuropilin 1 TM, CUB, FS_F8_ty C, MAM 4. 2 430806 S69377 Hs. 247978 T-cell acute ly TM, HLH 4. 1 414696 AF002020 Hs. 76918 Niemann-Pick di TM, SS, Patched 4. 1 408830 AK001709 Hs. 48403 hypothetical pr TM, UPF0013 4. 1 416655 AW968613 Hs. 79428 BCL2/adenovirus TM 4. 1 412494 AL133900 Hs. 792 ADP-ribosylatio TM, arf, zf-B_box, zf-C3HC4 4. 0 453195 BE241876 Hs. 32352 hypotheficalpr TM 4. 0 428816 AA004986 Hs. 193852 ATp-bindingsa TM, ABC_membrane, ABC_tran, COXlSCtaA 3. 9 401189 TM, SET, PHD, HMG_box 3. 8 451988 AF263928 Hs. 27410 papillomavirus TM 3. 8 421013 M62397 Hs. 1345 mutated in coto TM 3. 7 420041 AB005142 Hs. 94592 klotho TM, SS, Glyco_hydro_1 3. 7 432579 AF043244 Hs. 278439 nucleolar prote TM 3. 6 453496 AA442103 Hs. 33084 solute carrier TM, SS, sugars 3. 6 446636 AC002563 Hs. 15767 citron (rho-int TM, CNH, DAG PE-bind, PH, pkinase, pkinase_C 3. 6 426274 D38122 Hs. 2007 tumor necrosis TM, TNF 3. 6 452355 N54926 Hs. 29202 G protein-coupl TM, 7tm_1 3. 5 453775 NM002916 Hs. 35120 replication fac TM, SS, AAA 3. 4 426559 AB001914 Hs. 170414 paired basic am TM, Peptidase_S8, P 3. 4 420737 L08096 Hs. 99899 tumor necrosis TM, TNF 3. 4 448733 NM 005629 Hs. 187958 solutecarrier TM, SNF, ABC tran, isodh, pkinase, Ribosoma_L18ae 3. 4 413719 BE439580 Hs. 75498 small inducible SS, IL8 3. 4 427914 AA417350 Hs. 20575 ESTs TM, GAS2 3. 4 412642 BE244598 Hs. 809 hepatocyte grow kringlePANlrypsin 3. 4 421893 NM001078 Hs. 109225 vascular cell a TM, SS, ig 3. 3 417924 AU077231 Hs. 82932 cyclin D1 (PRAD TM, cyclin 3. 3 405257 TM 3. 3 450396 AU077002 Hs. 24950 regulator of G TM, RGS 3. 3 416892 L24498 Hs. 80409 growth arrest a TM, Ribosomal L7Ae 3. 3 425236 AW067800 Hs. 155223 stanniocalcin 2 SS 3. 3 430812 L10405 Hs. 247992 DNA binding pro TM, SS 3. 2 431842 NM005764 Hs. 271473 epithelial prot TM, SS 3. 2 424897 D63216 Hs. 153684 fizzled-relate TM, Fz, NTR 3. 2

414821 M63835 Hs. 77424 Fcfragmentof TM, SS, ig 3. 1 418030 BE207573 Hs. 83321 neuromedin B SS 3. 1 421633 AF121860 Hs. 106260 sortingnexint TM. PX 3. 1 441285 Nom002374 Hs. 167 microtubule-ass SS, tubulin-binding 3. 1 418526 BE019020 Hs. 85838 solute carrier TM, MCT 3. 1 401260 TM, SS 3. 1 450705 U90304 Hs. 25351 inzquois-cias TM, homeobox 3. 1 424415 NM_001975 Hs. 146580 enolase 2, (gam TM, SS, enolase 3, 0 403346 TM, alpha-amylase 3. 0 432757 AF113013 Hs. 278919 PR00806protein TM 3. 0 434398 AA121098 Hs. 3838 serum-inducible TM, pkinase, POLO-box 3. 0 424539 L02911 Hs. 150402 ætivinArecep TM, AcGvin ecp, pkinase 3. 0 406117 SS 3. 0 408119 W26213 gb : 22d10Human TM. SS 3. 0 431984 AL080239 Hs. 272284 Human DNA seque TM 3. 0 403782 TM 3. 0 447922 Z92910 Hs. 20019 hemochromatosis TM, SS, ig, MHC_I, histone, SPRY, zf-B_box, zf-C3HC4 3. 0 428857 AF008192 Hs. 194283 putative GR6 pr SS 3. 0 432596 AJ224741 Hs. 278461 matilin 3 SS 3. 0 453202 AW085781 Hs. 26270 Homo sapiens cD TM 3. 0 405547 TM, SS, ABC_membrane, ABC_tran 3. 0 423496 U91963 Hs. 129700 tolloid-like 1 TM, SS, EGF, CUB, Astacin 3. 0 401707 SS 3. 0 403144 TM, ion_trans, K_letra 3. 0 418375 NM 003081 Hs. 84389 synaptosomal-as TM, NA 3. 0 422992 AF016833 Hs. 122785 maitase-giucoam TM, GIy hydro_3l, trefoil 3. 0 406506 TM 3. 0 413472 BE242870 Hs. 75379 solutecarier TM, SDF 3. 0 TABLE 34B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 408119 1040172_1 W26213 H08055 Z44031 AW954559 R17434 454392 115882_1 BE260893 AA078319 R85057 AW803024 H85811 AA078293 TABLE 34C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers."Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 2Z Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 401157 9438289 Minus 114133-114247, 114567-114645 401189 9690246 Minus 90815-90929 401260 8076883 Minus 86008-86355 401352 9931258 Minus 26064-26208 401439 8246737 Plus 92993-94026 401707 2951946 Plus 21972-22104 402045 7923943 Plus 5964-6128 402421 9796341 Minus 46609-46662, 4675&46811, 86293-86346, 89776-89829, 90048-90101, 102817-102924 402696 7328818 Minus 23600-23731 402739 9212192 Plus 60456-61019 402921 7981303 Minus 52242-52384, 5559&55858, 57124-57309, 59633-59761, 59957-60123 403095 8954339 Plus 150025-150240, 151564-151690 403111 8980970 Plus 175012-175159 403144 9454649 Minus 166200-166628 403345 8569726 Plus 77890-78069 403346 8569726 Plus 92752-93015 403782 8078608 Plus 41326-41633 404115 9621489 Plus 232707-232982 404200 6010176 Minus 7066-7210 404347 9838195 Plus 74493-74829 404939 6862697 Plus 175318-175476 405257 7329310 Plus 73121-73273 405394 6624123 Minus 31900-32373 405547 1054740 Plus 124361-124520, 124914-125050 405609 5757553 Minus 42814-43010, 4358343783, 44863-45033, 46429-46554, 47815. 48018, 49961-50153, 51624-51727, 51823-51959, 52702-52918, 55463 55601, 57111-57307, 58169-58296, 6021560332. 61482-61727 406117 9142932 Plus 5430454584 406411 9256407 Plus 7400-7527 406414 9256407 Plus 49593-49850 406504 7711360 Minus 107068-107277 406506 7711374 Minus 6843-8077 406598 8248614 Plus 56373-56849 TABLE 35A : ABOUT 532 GENES UP-REGULATED IN KIDNEY CANCER Table 35A lists about 532 genes up-regulated in kidney cancer compared to normal kidney. These were selected as for Table 33A except using an'average'of the 70th pecentile for both the numerator and the denominator and using non-malignant kidney specimens in determining the denominator value.

Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of tumor to normal tissue Pkey ExAccn UnigenelD UnigeneTiGe R1 424704 Api263293 Hs. 152096 cytochrome P450, subfamily IIJ (arachido 40. 9 426559 AB001914 Hs. 170414 paired basic amino acid cleaving system 35. 6 458079 A1796870 Hs. 54277 ESTs 34. 6 433447 U29195 Hs. 3281 neuronal pentraxin 11 32. 0 439979 AW600291 Hs. 6823 hypothetical protein FU10430 29. 3 446921 AB012113 Hs. 16530 smali inducible cytokine subfamily A (Cy 25. 9 435359 T60843 Hs. 189679 ESTs 25. 4 450152 Api138635 Hs. 22968 ESTs 25. 2 452401 NM 007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 24. 8 440304 BE159984 Hs. 125395 ESTs 24. 5 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 23. 4 421155 H87879 Hs. 102267 lysyl oxidase 22. 4 452795 AW392555 Hs. 18878 hypotheGcal protein FU21620 22. 2 414812 X72755 Hs. 77367 monokine induced by gamma interferon 22. 1 426471 M22440 Hs. 170009 transforming growth factor, alpha 21. 3 427897 NM_017413 Hs. 181060 apelin ; peptide ligand for APJ receptor 21. 3 449523 NM 000579 Hs. 54443 chemokine (C-CmoG0receptorS 20. 7 436961 AW375974 Hs. 156704 ESTs 20. 5 447499 AW262580 Hs. 147674 MAA) 621 protein 20. 4 438817 A1023799 Hs. 163242 ESTs 20. 4 430630 AW269920 Hs. 2621 cystatin A (stefin A) 19. 8 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 19. 5 424086 Ai351010 Hs. 102267 lysyl oxidase 18. 7 425289 AW139342 Hs. 155530 interferon. gamma-inducible protein 16 18. 7 436476 AA326108 Hs. 53631 ESTs. Weakly similar to enhancer-of-spli 18. 7 415286 AW249540 Hs. 72548 ESTs 18. 2 428157 A1738719 Hs. 298668 ESTs 18. 1 456804 Al421645 Hs. 139351 caveolin 2 17. 8 429490 Al971131 Hs. 293684 ESTs, Weakly similar to alternatively sp 17. 5 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2 doma 17. 1 433757 A1949974 Hs. 152670 ESTs 16. 8 400419 AF084545 Hs. 81800 chondroiGn sulfate proteoglycan 2 (vers 16. 4 428046 AW812795 Hs. 155381 ESTs, Moderately similar to 138022 hypot 16. 3 411642 NM014932 Hs. 71132 neuroligin 1 16. 2 444381 BE387335 Hs. 283713 ESTs, Weakly similar to CA54 HUMAN COLLA 16. 0 435767 H73505 Hs. 117874 ESTs 15. 7 427581 NM 014788 Hs. 179703 KIAA0129 gene product 15. 6 448019 AW947164 Hs. 195641 ESTs 15. 6 406671 AA129547 Hs. 285754 met proto-oncogene (hepatocyte growth fa 15. 5 447835 AW591623 Hs. 164129 ESTs 15. 4 448520 AB002367 Hs. 21355 doublecortin and CaM kinase-like 1 14. 8 417308 H60720 Hs. 81892 KIAA0101 gene product 14. 8 432731 R31178 Hs. 287820 fibronectin 1 14. 7 421566 NM000399 Hs. 1395 early growth response 2 (Krox-20 (Drosop 14. 6 419235 AW470411 Hs. 288433 neurotrimin 14. 6 426490 NM 001621 Hs. 170087 aylhydrocarbonreceptor 14. 4 421485 AA243499 Hs. 104800 hypothetical protein FLJ10134 14. 4 422603 BE242587 Hs. 118651 hematopoiefically expressed homeobox 14. 4 418110 R43523 Hs. 217754 HomosapienscDNA : FU22202 fis, clone H 14. 2 425984 AW836277 Hs. 165636 hypothetical protein DKFZp761C07121 14. 2 432606 NM_002104 Hs, 3066 granzyme K (serine protease, granzyme 3 ; 14. 1 436772 AW975688 Hs. 250867 zona pellucida glycoprotein 3A (sperm re 14. 0 444969 A1203334 Hs. 160628 ESTs 13. 9 426890 AA393167 Hs. 41294 ESTs 13. 8 437330 AL353944 Hs. 50115 Homo sapiens mRNA ; cDNA DKFZp761J1112 (f 13. 8 458809 AW972512 Hs. 20985 sin3-associated polypeptide, 30kD 13. 7 446627 A1973016 Hs. 15725 hypotheGcal protein SBB148 13. 6 452960 AK001335 Hs. 31137 Homo sapiens cDNA : FU22681 fis, clone H 13. 3 417280 AW173116 Hs. 262206 ESTs 13. 1 422173 BE385828 Hs. 250619 phorbolin-like protein MDS019 13. 0 420552 AK000492 Hs. 98806 hypothetical protein 13. 0 425188 AK002052 Hs. 155071 hypothetical protein FU 11190 12. 6 427871 AW992405 Hs. 59622 ESTs, WeaklysimilartounknowntH. sapie 12. 6 446152 A1292036 Hs. 150028 ESTs 12. 5 426560 AA381661 Hs. 119878 ESTs 12. 4 419034 NM 002110 Hs. 89555 hemopoietic celi kinase 12. 3 456508 AA502764 Hs. 123469 ESTs. WeaklysimilartoAF2088551BM-01 12. 3 452281 T93500 Hs. 28792 Homo sapiens CDNA FU 11041 fis, clone PL 12. 3 442932 AA457211 Hs. 8858 bromodomain adjacent to zinc finger doma 12. 3 426075 AW513691 Hs. 270149 ESTs 12. 2 434398 AA121098 Hs. 3838 serum-inducible kinase 12. 2 450506 NM 004460 Hs. 418 fibroblast activation protein, alpha 12. 1 425782 U66468 Hs. 159525 celi growth regulatory with EF-hand doma 12. 0 426108 AA622037 Hs. 166468 programmed cell death 5 11. 9 416000 R82342 Hs. 79856 ESTs 11. 8 450236 AW162998 Hs. 24684 KIAA1376 protein 11. 7

449679 A1823951 Hs. 296668 HomosapienscDNAFUl1846fismcloneHE 11. 6 441350 AB020690 Hs. 7782 paraneoplastcanGgenMA2 11. 4 442227 AW771958 Hs. 175437 ESTs 11. 4 414004 AA737033 Hs. 7155 ESTs, Weaklysimilarto2115357ATYKipr 11. 4 447056 N67879 Hs. 157695 ESTs 11. 3 444863 AW384082 Hs. 301323 ESTs 11. 3 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 11. 2 426780 BE242284 Hs. 172199 adenyiatecyclae7 11. 1 453160 A1263307 Hs. 146228 ESTs 11. 1 449539 W80363 Hs. 58446 ESTs 11. 1 415323 BE269352 Hs. 949 neutrophil cytosolic factor 2 (65kD, chr 11. 0 423508 AW604297 Hs. 129711 hepatitis A virus cellular receptor 1 11. 0 408380 AF123050 Hs. 44532 diubiquitin 11. 0 448410 AK000227 Hs. 21126 hypotheticalprotein FLJ20220 11. 0 451277 AK001123 Hs. 26176 hypotheticalprotein FLJ10261 10. 8 453165 S74727 Hs. 32042 aspartoacylase (aminoæyiae 2, Canavan 10. 8 435380 AA679001 Hs. 192221 ESTs 10. 7 447183 Al554733 Hs. 173182 ESTs 10. 7 438330 AW450572 Hs. 257316 ESTs 10. 6 441392 AW451831 Hs. 222119 ESTs. Weakly similar to KICCLHUMAN KERAT 10. 5 418036 Z37976 Hs. 83337 latent transforming growth factor beta b 10. 5 452862 AW378065 Hs. 8687 ESTs 10. 4 431512 BE270734 Hs. 2795 tætatedehydrogenaseA 10, 3 421478 A1683243 Hs. 97258 ESTs 10. 3 413879 AA132961 Hs. 212533 Homo sapiens cDNA FLJ22572 fis, clone H 10. 3 411800 N39342 Hs. 5184 THi drosophilahomolog 10. 3 433862 D86960 Hs. 3610 KIAA0205 gene product 10. 3 440594 AW445167 Hs. 126036 ESTs 10. 2 414504 AW069181 Hs. 293523 ESTs, Weakly similar to transformation-r 10. 2 431211 M86849 Hs. 5566 gapjunction protein, beta 2, 26kD (conn 10. 2 437682 AA476652 Hs. 94952 Homo sapiens cDNA : FLJ23371 fis, clone H 10. 1 430097 A1523245 Hs. 127638 ESTs 10. 1 432579 AF043244 Hs. 278439 nucleolar protein 3 (apoptosis repressor 10. 0 434927 H46612 Hs. 293815 Homo sapiens HSPC285 mRNA, partial cds 9. 9 424113 A1743880 Hs. 12876 ESTs 9. 9 439981 Api348408 Hs. 124675 ESTs, Weakly similar to unnamed protein 9. 9 411937 AW876626 gb : RC3-PT0026-120200-013dO8PT0028Homo 9. 9 439653 AW021103 Hs. 6631 hypothetical protein FLJ20373 9. 9 428862 NM 000346 Hs. 2316 SRY (sex-determining regions-box 9 (ca 9. 8 424623 AW963062 Hs. 165809 ESTs 9. 8 410762 AF226053 Hs. 66170 HSKM-B protein 9. 8 433285 AW975944 Hs. 237396 ESTs 9. 7 413795 AL040178 Hs. 142003 ESTs 9. 6 434392 AW983709 Hs. 268051 ESTs 9. 6 435542 AA687376 Hs. 269533 ESTs 9. 6 430887 N66801 Hs. 260287 ESTs, Weakly similar to ALU7 HUMAN ALU S 9. 5 410339 A1916499 Hs. 298258 ESTs 9. 5 452431 U88879 Hs. 29499 toll-like receptor 3 9. 5 405121 AB028989 Hs. 88500 mitogen-activated protein kinase 8 inter 9. 5 408134 AK000184 Hs. 42945 acid sphingomyelinase-like phosphodieste 9. 4 438966 AW979074 gb : EST391184 MAGE resequences, MAGP Homo 9. 4 449625 NM014253 Hs. 23796 odz (odd Oz/ten-m, Drosophila} homolog 1 9. 4 441024 AW081530 Hs. 137088 ESTs 9. 3 445900 AF070526 Hs. 13429 Homo sapiens clone 24787 mRNA sequence 9. 2 433001 AF217513 Hs. 279905 clone HQ0310 PR00310p1 9. 2 440074 AA863045 Hs. 199057 ESTs, Weakly similar to T00050 hypotheti 9. 2 421659 NM 014459 Hs. 106511 protocadherin 17 9. 2 434542 AA769310 Hs. 61260 hypothebcal protein FUlal64 9. 1 427283 AL119796 Hs. 174185 ectonucleoGde pyrophosphatase/phosphodi 9. 1 428820 AA436187 Hs. 172631 integrin, alpha M (complement component 9. 1 419441 AW023731 Hs. 274368 Homo sapiens mRNA ; cDNA DKFZpS8611524 ( 9. 0 407856 AA045281 Hs. 266175 phosphoprotein associated with GEMs 9. 0 431941 AK000106 Hs. 272227 Homo sapiens cDNA FU20099 fis, clone CO 9. 0 446460 AW013999 Hs. 150164 ESTs 8. 9 452598 Api831594 Hs. 68647 ESTs, Weakly similar to ALU7 HUMAN ALU S 8. 9 407975 X89426 Hs. 41716 endothelial cell-specific molecule 1 (NO 8. 9 437259 A1377755 Hs. 120695 ESTs 8. 7 420235 AA256756 Hs. 31178 ESTs 8. 7 436959 AL133076 Hs. 5354 hypothetica) protein FU12716 8. 7 413554 AA319146 Hs. 75426 secretograninll (chromograninC) 8. 6 435894 A1076667 Hs. 188011 ESTs 8. 6 418693 A1750878 Hs. 87409 thrombospondin 1 8. 6 425770 NM 014363 Hs. 159492 spasticataxiaofCharievoix-Saguenay (s 8. 6 456249 Ai206144 Hs. 82508 HRIHFB2206 protein 8. 6 437672 AW748265 Hs. 5741 f avohemoprotein bS+bSR 8. 6 430268 AK000737 Hs. 237480 hypothetical protein FU20730 8. 5 417225 AA815048 Hs. 24078 Homo sapiens CDNA FU12649 fis, clone NT 8. 5 435266 AK001942 Hs. 4863 Homo sapiens DNA 1080 fis. done PL 8. 4 447974 R76886 gb : yi64bO3. sl Scares placenta Nb2HP Homo 8. 4 447850 AB018298 Hs. 19822 SEC24 (S. cerevisiae) related gene famil 8. 4 429525 N92540 Hs. 205353 ectonucleoside triphosphate diphosphohyd 8. 3 435717 AF227905 Hs. 105794 UDpslucose : glycoprotein glucosyltransfe 8. 3 445784 A1253155 Hs. 146065 ESTs 8. 3

454024 AA993527 Hs. 16281 hypothetical protein FU23403 8. 3 443885 H91806 Hs. 15284 ESTs 8. 3 403713 8. 3 433376 Api249361 Hs. 74122 caspase 4, apoptosis-related cysteine pr 8. 2 419490 NM006144 Hs. 90708 granzymeA (granzymel, cytotoxicT-lymp 8. 2 444670 H58373 Hs. 37494 ESTs 8. 2 408761 AA057264 Hs. 238936 ESTs 8. 2 453033 AA325869 Hs. 31463 KIAA0281 gene product 8. 2 441224 AU076964 Hs. 7753 calumenin 8. 1 441689 A1123705 Hs. 106932 ESTs 8. 1 440283 A1732892 Hs. 190489 ESTs 8. 1 429598 AA811257 Hs. 269710 ESTs 8. 1 424775 AB014540 Hs. 153026 SWAP-70 protein 8. 1 451292 AB037716 Hs. 26204 KIAA1295 protein 8. 0 453951 A1676235 Hs. 24789 ESTs 8. 0 416200 Al188972 Hs. 44257 Homo sapiens mRNA ; cDNA DKFZp76202215 (f 8. 0 431087 H12723 Hs. 290791 ESTs 8. 0 432328 Api572739 Hs. 195471 6-phosphofructo-2-kinaselfructose-2, 6-bi 7. 9 419474 AW968619 Hs. 155849 ESTs 7. 9 418342 BE002723 Hs. 293504 ESTs, Moderately similar to ALU 1-HUMAN A 7. 9 408088 AW157022 Hs. 4947 Homo sapiens CDNA : FU22584 fis, clone H 7. 9 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy 7. 9 440987 AA911705 Hs. 130229 ESTs 7. 9 412448 L12964 Hs. 73895 tumor necrosis factor receptor superfami 7. 9 415737 AA167626 Hs. 118743 ESTs 7. 9 412959 D87458 Hs. 75090 KIAA0282 protein 7. 8 424247 X14008 Hs. 234734 lysozyme (renal amyloidosis) 7. 8 453331 A1240665 Hs. 8895 ESTs 7. 8 421991 NM 014918 Hs. 110488 KIAA0990 protein 7. 8 443450 N66045 Hs. 133529 ESTs 7. 8 431876 AA521183 Hs. 269678 ESTs 7. 8 432582 A1623817 Hs. 168457 ESTs 7. 7 445800 AA126419 Hs. 301632 ESTs 7. 7 424636 AA453734 Hs. 10198 ESTs 7. 7 432134 Al816782 Hs. 122583 Hbmosapienssf) NA : FLJ21934 fis, clone H 7. 7 446873 A1554439 Hs. 30724 ESTs 7. 7 400793 AA635062 Hs. 50094 Homo sapiens mRNA ; cONA DKFZp43400515 (f 7. 7 436061 AI248584 Hs. 190745 Homo sapiens cDNA : FU21326 fis, clone C 7. 7 442028 A1239437 Hs. 48945 ESTs 7. 7 442760 BE075297 Hs. 10067 ESTs, Weakly similar to KIAA1205 protein 7. 7 442152 R39246 Hs. 239666 Homo sapiens cDNA FLJ13495 fis, clone PL 7. 7 427944 AA417878 Hs. 48401 ESTs, WeaklysimilartoALU8_HUMANALUS 7. 6 414646 M353776 Hs. 901 CD48 antigen (B-cell membrane protein) 7. 6 407634 AW016569 Hs. 301280 ESTs, Highly similar to AF241831 I intra 7. 6 418372 AA311833 Hs. 84318 replication protein Al (70kD) 7. 6 434666 AF151103 Hs. 112259 T cell receptor gamma locus 7. 6 442432 BE093589 Hs. 38178 Homo sapiens cDNA : FLJ23468 fis, done H 7. 6 408418 AW963897 Hs. 44743 KIAA1435 protein 7. 6 418805 A1829520 Hs. 227513 ESTs 7. 5 425354 U62027 Hs. 155935 complement component 3a receptor 1 7. 5 408743 AL110246 Hs. 47367 hypothetical protein from EUROIMAGE 7836 7. 5 444836 A1589825 Hs. 173504 ESTs, Weakly similar to JC5238 galactosy 7. 5 421810 AK001718 Hs. 108530 hypotheticalprotein FLJ10856 7. 4 432753 NM 014075 Hs. 278915 PR00593 protein 7. 4 420061 AW024937 Hs. 29410 ESTs 7. 4 432865 A ! 753709 Hs. 152484 ESTs 7. 4 419070 AW979068 Hs. 182503 ESTs 7. 4 430172 AA468591 Hs. 161889 ESTs 7. 4 446343 AW771414 Hs. 8314 ESTs 7. 4 424125 M31669 Hs. 1735 inhibin, beta 8 (activin AB beta pdypep 7. 4 453818 BE256832 Hs. 10711 Homo sapiens cDNA FLJ13449 fis, clone PL 7. 4 447046 AA326187 Hs. 17170 G protein-coupled receptor 4 7. 4 410577 X91911 Hs. 64639 glioma pathogenesis-related protein 7. 4 452240 A1591147 Hs. 61232 ESTs 7. 3 450375 AA009647 Hs. 8850 a disintegrin and metalloproteinae doma 7. 3 422631 BE218919 Hs. 118793 hypothetical protein FLJ 10688 7. 3 450205 A1219748 Hs. 11356 ESTs 7. 3 437212 A1765021 Hs. 210775 ESTs 7. 3 440193 AW902312 Hs. 7037 pallid (mouse) homolog, pallidin 7. 2 417022 NM_014737 Hs. 80905 Ras association (RaIGDSIAF-6) domain fam 7. 2 451818 A1819018 gb : ts54f01. xlNCI CGAP Kid8Homosapiens 7. 2 453013 AA031407 gb : zk15g12. r1 Soãres_pregnant_utenus_NbH 7. 2 430105 X70297 Hs. 2540 choiinergic receptor, nicobnic, alpha p 7. 2 451621 Api879148 Hs. 26770 fatty acid binding protein 7, brain 7. 2 442438 AA995998 gb : os26b03. s1 NCl_CGAP_KidSHomosapiens 7. 2 415138 C18356 Hs. 78045 tissue factor pathway inhibitor 2 7. 2 407305 AA715284 gb : nv35fO3. rlNCI CGAP BrSHomosapiens 7. 2 452814 AI092790 Hs. 55016 hypothetical protein FLJ21935 7. 2 426028 Nom-001110 Hs. 172028 adisintegrinandmetalloproteinasedoma 7. 2 443462 A1064690 Hs. 171176 ESTs 7. 2 422060 R20893 Hs. 75613 CD36 antigen (collagen type I receptor, 7. 2 434096 AW662958 Hs. 75825 pleiomorphic adenoma gene-like 1 7. 1 443161 Al038316 gb : ox48cO3. x1 Soares_totå_fetus_Nb2HF8_ 7. 1

458725 AW970192 Hs. 171942 ras responsive element binding protein 1 7. 1 426423 NM 012446 Hs. 169833 single stranded-DNA-binding protein 7. 1 412783 BE276738 Hs. 74578 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 7. 1 435664 A1032087 Hs. 269819 ESTs 7. 0 431708 A1698136 Hs. 108873 ESTs 7. 0 426501 AW043782 Hs. 293616 ESTs 7. 0 453548 AL079983 Hs. 75442 albumin 7. 0 426595 AW971980 Hs. 62402 p21/Cdc42/Rac1-activatedt<inase1 (yeast 7. 0 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FW22528 fis, clone H 7. 0 431556 AF016028 Hs. 260039 sarcospan (Kras oncogene-associated gene 6. 9 420018 U56387 Hs. 94376 pnoproteinconvertaesubUlisinikexint 6. 9 418986 A1123555 Hs. 81796 ESTs 6. 9 430290 A1734110 Hs. 136355 ESTs 6. 9 427472 AA522539 Hs. 131250 transposon-derivedBuster3transposase-l 6. 9 444042 NM 004915 Hs. 10237 ATP-binding cassette, sub-family G (WHIT 6. 9 414737 Al160386 Hs. 12S087 ESTs 6. 9 420479 AW183695 Hs. 186572 ESTs 6. 9 432656 NM 000246 Hs. 3076 MHC class 11 transacbvator 6. 9 414217 Al309298 Hs. 279898 Homo sapiens cDNA : FU23165 fis, clone L 6. 9 431870 AW449902 Hs. 105500 ESTs 6. 9 415788 AW628686 Hs. 78851 KIAA0217 protein 6. 9 430066 At929659 Hs. 237825 signal recognition particle 72kD 6. 9 437156 A1916600 Hs. 121194 Homo sapiens cDNA : FU21569fis, clone C 6, 8 401539 6. 8 412782 A1189211 Hs. 173044 ESTs 6. 8 416058 L08895 Hs. 78995 MADS box transcription enhancer factor 2 6. 8 437205 AL110232 gb : Homo sapiens mRNA ; cDNA DKFZp564D2071 6. 7 458814 A1498957 Hs. 170861 ESTs 6. 7 452106 A1141031 Hs. 21342 ESTs 6. 7 413249 AF167160 Hs. 75251 DEAD/H (Asp-Glu-Ala-Asp/His) box binding 6. 7 420910 AL049437 Hs. 100292 Homo sapiens mRNA ; cDNA DKFZp586E1120 (f 6. 7 445527 W39694 Hs. 83286 ESTs 6. 7 424063 NM 002019 Hs. 138671 fms-related tyrosine kinase 1 (vascu) ar 6. 7 421977 W94197 Hs. 110165 ribosomal protein L26 homolog 6, 7 430280 AA361258 Hs. 237868 interleukin 7 receptor 6. 7 415989 Al267700 Hs. 111128 ESTs 6. 7 418026 BE379727 Hs. 83213 fatty acid binding protein 4, adipocyte 6. 6 425295 AA431366 Hs. 37251 ESTs 6. 6 438619 AB032773 Hs. 6341 TU12B1-TYprotein 6. 6 424916 AW867440 Hs. 23096 ESTs 6. 6 429697 AW296451 Hs. 24605 ESTs 6. 6 408741 M73720 Hs. 646 carboxypeptidaeA3 (matcell) 6. 6 403549 6. 6 449008 AW578003 Hs. 22826 tropomodulin 3 (ubiquitous) 6. 6 435798 BE395289 Hs. 12720 eIF4E-transporter 6. 6 447217 BE465754 Hs. 17778 neuropilin 2 6. 6 453070 AK001465 Hs. 31575 SEC63, endoplasmic reticulum translocon 6. 6 410276 A1554545 Hs. 68301 ESTs 6. 6 435391 AA704588 Hs. 58934 ESTs 6. 6 421878 AA299652 Hs. 111496 HomosapienscDNAFLJ11643fis, cloneHE 6. 6 452092 BE245374 Hs. 27842 hypothetical protein FLJ11210 6. 5 448789 BE539108 Hs. 22051 Homo sapiens mRNA ; cDNA DKFZp4340119 (fr 6. 5 425331 AW962128 gb : EST374201 MAGE resequences, MAGG Homo 6. 5 431956 AK002032 Hs. 272245 Homo sapiens DNA FLJ11170 fis, clone PL 6. 5 444880 AW118683 Hs. 154150 ESTs 6. 5 434131 A1858275 Hs. 143659 ESTs 6. 5 446658 A1440137 Hs. 164989 ESTs 6. 5 408150 BE620274 Hs. 43112 Homo sapiens mRNA ; cDNA DKFZp434B1620 (f 6. 5 403790 6. 5 417129 A1381800 Hs. 143275 Homo sapiens cDNA FLJ 13233 fis, clone OV 6. 5 452119 A1656378 Hs. 33461 ESTs 6. 4 437396 BE140396 Hs. 21621 hypothetical protein OKFZp7620076 6, 4 458946 AA009716 Hs. 42311 ESTs 6. 4 452110 T47667 Hs. 28005 Homo sapiens mRNA ; cDNA DKFZp564G2463 (f 6. 4 449318 AW236021 Hs. 108788 ESTs. Weakly similar to zeste (D. melanog 6. 4 408308 AL033377 Hs. 44197 hypothetical protein DKFZp564D0462 6. 4 402474 6. 4 430712 AW044647 Hs. 196284 ESTs 6. 4 418299 AA279530 Hs. 83968 integnn, beta 2 (antigen CD18 (p95), ly 6. 4 432683 AW995441 Hs. 10475 ESTs 6. 4 423764 AF054589 Hs. 132739 ESTs 6. 4 409571 AA504249 Hs. 187585 ESTs 6. 4 401600 BE247275 Hs. 151787 U5snRNP-specific protein, 116 kD 6. 4 415076 Nom000857 Hs. 77890 guanylatecyclael, soluble, beta3 6. 4 432925 AA878324 Hs. 192734 ESTs 6. 4 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 6. 4 453894 AW937825 Hs. 56847 Homo sapiens cDNA FW 12874 fis, clone NT 6. 4 430335 D80007 Hs. 239499 KIAA0185 protein 6. 3 453370 A1470523 Hs. 182356 ESTs, Moderately similar to translation 6. 3 421327 AA837295 Hs. 188802 ESTs 6. 3 450654 AJ245587 Hs. 25275 Kruppel-type zinc finger protein 6. 3 413497 BE177661 gb : RC1-HT0598 020300-011-hO2 HT0598 Homo 6. 3 445279 R41900 Hs. 22245 ESTs 6. 3

429747 M87507 Hs. 2490 caspase 1, apoptosis-related cysteine pr 6. 3 421252 AA765930 Hs. 130878 ESTs 6. 3 432140 AK000404 Hs. 272688 hypothetical protein FLJ20397 6. 3 434203 BE262677 Hs. 283558 hypothetical protein PR01855 6. 2 419436 AA991639 Hs. 15036 ESTs, HighlysimilartoAF1613531 HSPCO 6. 2 430287 AW182459 Hs. 125759 ESTs, Weakly similar to tumor suppressor 6. 2 409690 W45393 Hs. 94642 ESTs, Highly similar to ATFa tH. sapiensl 6. 2 420101 AW500529 Hs. 95180 HomosapiensmRNA ; cDNADKFZp434A205 (fr 6. 1 435889 A1249107 Hs. 269901 ESTs 6. 1 417259 AW903838 Hs. 81800 chondroitin suHate proteoglycan 2 (vers 6. 1 448030 N30714 Hs. 20161 HDCME31Pprotein 6. 1 442571 C06338 Hs. 165464 ESTs 6. 1 421202 AF193339 Hs. 102506 eukaryo6c translationinitiationfactor 6. 1 415558 AA885143 Hs. 125719 ESTs 6. 1 408042 AL049233 Hs. 42244 Homo sapiens mRNA ; cDNA DKFZp564A023 (fr 6. 1 438086 AA336519 Hs. 301167 HomosapienscDNA : FLJ21545 fis, clone C 6. 1 427390 Api432163 Hs. 268231 Homo sapiens cDNA : FU23111 fis, clone L 6. 0 440749 W22335 Hs. 7392 Homo sapiens mRNA ; cONA DKFZp761 E0323 (f 6. 0 448822 BE149845 Hs. 289038 Homo sapiens cDNA : FU20994 fis, clone C 6. 0 424806 AA382523 Hs. 105689 ESTs 6. 0 435185 AA669490 Hs. 289109 dimethyiargininedimethytaminohydrotase 6. 0 452235 AL039743 Hs. 28514 Homo sapiens mRNA ; cDNA DKFZp434H092 (fr 6. 0 432415 T16971 Hs. 289014 ESTs 6. 0 436345 AA873008 Hs. 121572 ESTs 6. 0 439451 AF086270 Hs. 278554 heterochromatin-likeprotein 1 6. 0 434674 AA831879 Hs. 136985 ESTs 6. 0 429653 Nom 005955 Hs. 211581 metal-regulatory transcription factor 1 6. 0 446822 AB037794 Hs. 16229 KIM1373 protein 6. 0 423590 AW952412 Hs. 65874 ESTs 6. 0 424026 A1798295 Hs. 123218 ESTs 5. 9 423246 AL119114 Hs. 23107 ESTs 5. 9 420982 AW576160 Hs. 100729 KIAA0692 protein 5. 9 435008 AF150262 Hs. 162898 ESTs 5. 9 420092 AA814043 Hs. 88045 ESTs 5. 9 444484 AK002126 Hs. 11260 hypotheUcalproteinFW11264 5. 9 410193 AJ132592 Hs. 59757 zinc finger protein 281 5. 9 450534 A1570189 Hs. 25132 KIAA0470 gene product 5. 9 440146 AW014231 Hs. 90790 Homo sapiens cDNA : FLJ22930 fis, clone K 5. 9 425361 AA355933 Hs. 132221 Homo sapiens CDNA FLJ 12401 fis, clone MA 5. 9 425174 D87450 Hs. 154978 KIAA0261 protein 5. 9 458287 AA987556 Hs. 12867 ESTs 5. 9 433793 AW975959 Hs. 107513 ESTs, Moderately similar to KIAA1058 pro 5. 8 443228 W24781 Hs. 293798 ESTs 5. 8 419983 W55956 Hs. 94030 Homo sapiens mRNA ; cDNA DKFZp586E1624 (f 5. 8 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-5. 8 415714 NM002290 Hs. 78672 laminin, alpha 4 5. 8 421689 N87820 Hs. 106826 hypothetical protein 5. 8 431176 A1026984 Hs. 293662 ESTs 5. 8 443837 At984625 Hs. 9884 spindle pole body protein 5. 8 410623 AW958932 Hs. 293833 ESTs 5. 8 421298 AW172431 Hs. 13012 ESTs 5. 8 449052 AW029507 Hs. 161102 ESTs 5. 8 433043 W57554 Hs. 125019 ESTs, Highly similar to K) AA0886 protein 5. 8 439444 A1277652 Hs. 54578 ESTs 5. 7 428698 AA852773 Hs. 297939 ESTs, Weakly similar to T17344 hypotheti 5. 7 411928 AA888624 Hs. 19121 adaptor-related protein complex 2, alpha 5. 7 442242 AV647908 Hs. 90424 Homo sapiens cDNA : FLJ23285 fis, clone H 5. 7 417315 A1080042 Hs. 180450 ribosomal protein S24 5. 7 422544 AB018259 Hs. 118140 KIAA0716 gene product 5. 7 412584 X54870 Hs. 74085 DNA segment on chromosome 12 (unique) 24 5. 7 433505 AW504027 Hs. 15301 Homo sapiens NY-REN-25 antigen mRNA, par 5. 7 410425 BE278367 Hs. 63510 KIAA0141 gene product 5. 7 457292 AI921270 Hs. 214178 Homo sapiens CDNA FLJ 14251 fis, clone OV 5. 7 457100 AA417878 Hs. 48401 ESTs, Weakly similar to ALU8_HUMAN ALU S 5. 7 436995 Api160015 Hs. 118112 ESTs 5. 7 426283 NM003937 Hs. 169139 kynureninase (L-kynurenine hydrolase) 5. 7 441518 AW161697 Hs. 294150 ESTs 5. 7 448807 A1571940 Hs. 7549 ESTs 5. 7 449656 AA002008 Hs. 188633 ESTs 5. 7 439211 Al890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 5. 7 430440 X52599 Hs. 2561 nerve growth factor, beta polypeptide 5. 7 413551 BE242639 Hs. 75425 ubiquitin associated protein 5. 7 441633 AW958544 Hs. 112242 ESTs 5. 7 427093 AA398118 Hs. 97579 ESTs 5. 6 418250 U29926 Hs. 83918 adenosine monophosphate deaminase (isofo 5. 6 432267 AK000872 Hs. 274227 Homo sapiens cDNA FW 10010 fis, clone HE 5. 6 419839 U24577 Hs. 93304 phospholipase A2, group VII (platelet-ac 5. 6 430253 AK001514 Hs. 236844 hypothetical protein FLJ10652 5. 6 450447 AF212223 Hs. 25010 hypothetical protein P15-2 5. 6 434623 AB023163 Hs. 4014 KIAA0946 protein ; Huntingtin interacting 5. 6 420642 AK001520 Hs. 99545 Homo sapiens CDNA FU 10658 fis, clone NT 5. 6 414020 NM002984 Hs. 75703 small inducible cytokine A4 (homologous 5. 6 420825 A1656727 gb : tt53f12. x1NaCGAPGC6 Homo sapiens 5. 6

422363 T55979 Hs. 115474 replication factor C (activator 1) 3 (38 5. 6 452046 AB018345 Hs. 27657 KIAA0802 protein 5. 6 408911 AW294772 Hs. 98321 Homo sapiens cDNA FLJ 14103 fis, clone MA 5. 6 414844 AA296874 Hs. 77494 deoxyguanosine kinase 5. 6 416498 U33632 Hs. 79351 potassium channel, subfamily K, member 1 5. 6 430512 AF182294 Hs. 241578 U6 snRNA-associated Sm-like protein LSmB 5. 6 430339 W28608 Hs. 239625 integral membrane protein 28 5. 6 420153 N22120 Hs. 75277 hypothetical protein FU13910 5. 6 420892 AW975076 Hs. 172589 nuclear phosphoprotein similar to S. cer 5. 6 441568 A1733322 Hs. 127176 ESTs 5. 5 414575 H11257 Hs. 295233 ESTs 5. 5 419929 U90268 Hs. 93810 cerebral cavernous malformations 1 5. 5 438613 C05569 Hs. 243122 hypothetical protein FLJ13057 similar to 5. 5 453064 R40334 Hs. 301395 HomosapienscDNA : FLJ21204 fis, clone C 5. 5 433409 A1278802 Hs. 25661 ESTs 5. 5 407094 AF000574 Hs. 22405 leukocyte immunoglobulin-like receptor, 5. 5 425234 AW152225 Hs. 165909 ESTs 5. 5 447644 AW861622 Hs. 108646 Homo sapiens CDNA FLJ 12534 fis, clone NT 5. 5 411653 AF070578 Hs. 71168 Homo sapiens clone 24674 mRNA sequence 5. 5 446534 A1307356 Hs. 175225 ESTs 5. 5 452355 N54926 Hs. 29202 G protein-coupled receptor 34 5. 5 434715 BE005346 Hs. 116410 ESTs 5. 5 440486 BE243513 Hs. 7212 hypothetical protein PP1044 5. 5 444825 AW167613 Hs. 248 mitogen-activated protein kinase kinase 5. 5 419172 AW338625 Hs. 22120 ESTs 5. 4 444931 AV652066 Hs. 75113 generaltranscriptionfactorIIlA 5. 4 413940 A1633205 Hs. 159914 ESTs 5. 4 410480 R97457 Hs. 63984 cadherin 13, H-cadherin (hear) 5. 4 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 5. 4 434361 AF129755 Hs. 117772 ESTs 5. 4 453392 U23752 Hs. 32964 SRY (sex determining region Y)-box 11 5. 4 445175 AV652851 Hs. 300846 ESTs 5. 4 411213 AA676939 Hs. 69285 neuropilin 1 5. 4 412530 AA766268 Hs. 266273 Homo sapiens cDNA FLJ13346 fis, clone OV 5. 4 422667 H25642 Hs. 133471 ESTs 5. 4 434064 AL049045 Hs. 180758 hypothetical protein PR00082 5. 4 429688 BE245169 Hs. 211610 CUGtripletrepeat, RNA-bindingprotein 5. 4 452060 W26980 Hs. 153612 ATP-binding cassette, sub-family F (GCN2 5. 4 419093 A1804054 Hs. 112885 ESTs 5. 4 436267 AW450938 Hs. 180115 ESTs 5. 4 405257 5. 4 431154 AW971228 Hs. 290259 ESTs 5. 4 415511 Al732617 Hs. 182362 ESTs 5. 4 419175 AW270037 Hs. 179507 KIAA0779 protein 5. 3 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 5. 3 423720 AL044191 Hs. 23388 Homo sapiens cDNA : FLJ21310 fis, clone C 5. 3 409995 AW960597 Hs. 30164 ESTs 5. 3 414911 NM 000107 Hs. 77602 damage-specific DNA binding protein 2 (4 5. 3 455716 BE070263 gb : QV4-BT0407-280100-090-e07BT0407Homo 5. 3 430598 AK001764 Hs. 247112 hypothetical protein FLJ10902 5. 3 419985 H66373 Hs. 15973 ESTs, Highly similar to bA393J16. 3 [H. sa 5. 3 428753 AW939252 Hs. 192927 hypothetical protein FLJ20251 5. 3 423099 NM 002837 Hs. 123641 protein tyrosine phosphatase, receptor t 5. 3 404176 5. 3 431475 Al567669 Hs. 287316 ESTs 5. 3 406625 Y13647 Hs. 119597 stearoyl-CoAdesaturase (delta-9-desatur 5. 3 405475 5. 3 430180 AA331406 Hs. 75456 A kinase (PRKA) anchor protein 10 5. 3 446183 AA354991 Hs. 14222 Homo sapiens mRNA ; cDNA DKFZp761P019 (fr 5. 3 417381 AF164142 Hs. 82042 solute carrier family 23 (nucleobase tra 5. 3 433029 NM 014322 Hs. 279926 opsin 3 (encephalopsin) 5. 3 442837 A1022082 Hs. 50492 ESTs 5. 3 437140 AA312799 Hs. 283689 activator of CREM in tesfis 5. 3 408989 AW361666 Hs. 49500 KIAA0746 protein 5. 3 417355 D13168 Hs. 82002 endothelin receptor type B 5. 3 407361 AA744622 Hs. 292645 ESTs. Weakly similar to ALU5_HUMAN ALU S 5. 3 437734 AA693951 Hs. 180284 ESTs 5. 3 452234 AW084176 Hs. 223296 ESTs 5. 3 423057 AW961597 Hs. 130816 ESTs 5. 3 439593 BE073597 Hs. 124863 ESTs 5. 3 446501 A1302616 Hs. 150819 ESTs 5. 3 416406 D86961 Hs. 79299 lipoma HMGIC fusion partner-like 2 5. 2 427164 AB037721 Hs. 173871 KIAA1300 protein 5. 2 416815 U41514 Hs. 80120 UDP-N-acetyl-alpha-D-galactosamine : polyp 5. 2 448212 Api475858 gb : tc87dO7. x1 NCI_CGAP_CLL1 Homosapiens 5. 2 412420 AL035668 Hs. 73853 bone morphogenetic protein 2 5. 2 416975 Nom-004131 Hs. 1051 granzymeB (granzyme2, cytotoxicT-lymp 5. 2 406815 AA833930 Hs. 288036 tRNA isopentenylpyrophosphate transferas 5. 2 451418 BE387790 Hs. 26369 hypothetical protein FLJ20287 5. 2 425322 U63630 Hs. 155637 protein kinase, DNA-activated, catalytic 5. 2 451156 A1983569 Hs. 232042 ESTs 5. 2 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor 1 5. 2 423024 AA593731 Hs. 75613 CD36 antigen (collagen type I receptor, 5. 2

428593 AW207440 Hs. 185973 degenerative spermatocyte (homolog Droso 5. 2 451149 AL047586 Hs. 10283 ESTs 5. 2 429458 BE161832 Hs. 292689 ESTs 5. 2 422241 Y00062 Hs. 170121 protein tyrosine phosphatase, receptor t 5. 2 432383 AK000144 Hs. 274449 Homo sapiens cDNA FW20137 fis, clone CO 5. 2 417696 BE241624 Hs. 82401 CD69 antigen (p60, early T-cell ælivati 5. 2 442991 BE281238 Hs. 8886 hypothetical protein FLJ20424 5. 2 426711 AA383471 Hs. 180669 conservedgeneamplifiedinosteosacoma 5. 2 438995 A1277986 Hs. 164875 ESTs 5. 1 438582 A1521310 Hs. 283365 ESTs, Weakly similar to ALUS HUMAN ALU S 5. 1 424859 U92014 Hs. 153527 HomosapienspTMSmanner-liketransposo 5. 1 445563 AW873606 Hs. 149006 ESTs 5. 1 416852 AF283776 Hs. 80285 Homo sapiens mRNA ; cDNA DKFZp586C1723 (f 5. 1 420567 AK000812 Hs. 98874 similar to proline-rich protein 48 5. 1 420630 AL133101 Hs. 99508 Homo sapiens mRNA ; cDNA DKFZp43400921 (f 5. 1 455510 AA422029 Hs. 143640 ESTs, Weaklysimilartohyperpolarizatio 5. 1 412676 NM_000165 Hs. 74471 gap junction protein, alpha 1, 43kD (con 5. 1 438146 Z36842 Hs. 57548 ESTs 5. 1 423430 AF112481 Hs. 128501 RAD54. S. cerevisiae, homolog of, B 5. 1 421633 AF121860 Hs. 106260 sorting nexin 10 5. 1 447197 R36075 gb : yh88bO1. s1 Scares piacentaNb2HP Homo 5. 1 436943 AA773838 Hs. 5353 caspase 10, apoptosis-related cysteine p 5. 1 456210 N49729 Hs. 156875 ESTs 5. 1 411893 R82845 Hs. 273789 ESTs 5. 1 432331 W37862 Hs. 274368 Homo sapiens mRNA ; cDNA DKFZpS8611524 ( 5. 1 414696 AF002020 Hs. 76918 Niemann-Pickdisease, typeC1 5. 1 426822 W78950 Hs. 220823 ESTs 5. 1 444269 A1590346 Hs. 146220 ESTs 5. 1 437204 AL110216 Hs. 12285 ESTs 5. 1 443180 R15875 Hs. 70945 ESTs 5. 1 431510 AA580082 Hs. 112264 ESTs 5. 0 446312 BE087853 gb : QV1-BT0681-290400-181-h05 BT0681 Homo 5. 0 449870 A1672487 Hs. 15423 hypothetical protein HDCMC04P 5. 0 430462 A1584156 Hs. 105640 ESTs 5. 0 457452 AW972675 gb : EST384766 MAGE resequences, MAGL Homo 5. 0 420397 NM007018 Hs. 97437 centrosomal protein 1 5. 0 408750 BE294069 Hs. 93581 hypothetical protein FU10512 5. 0 426874 N67325 Hs. 247132 ESTs 5. 0 419746 AW867943 Hs. 127216 HomosapienscDNAFW13465fis, clonePL 5. 0 434237 AF119908 Hs. 235516 hypothetical protein PR02955 5. 0 410274 AA381807 Hs. 61762 hypoxia-inducible protein 2 5. 0 TABLE 35B : Pkey : Unique Eos probeset identifier number CAT number. Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 411937 1266219_1 AW876626 AW876622 AW876624 413497 1373771_1 BE177661 H06215 BE144709BE144829 420825 196769 1 AI656727 AI697887 AI802122 AA910877 Z28718 T16711 AA651731 AL047264 BE000621 R68736 AW992695 AI768764 AW271284 AW974653 Ai308951 AW055146 R93609 AW467031 A1096866 AI371871 AI126182 AI564756 AI361460 AI358914 AI419231 AW439733 R87059 AA628064 AW088970 AW008695 R68682 Ai719136 R97752 AW196262 425331 250199J AW962128AA355353AA427363 437205 434631 AL110232 N94765 438966 467436_1 AW979074M834841 M828650 442438 542469 1 AA995998 A1916584 R61781 T77332 F07756 F08149 F07647 443161 561305 1 A1038316 A1344631 A1261653 446312 671114 1 BE087853 A1286184 447197 711623-1 R36075 A1366546 R36167 447974 745643 1 R76886 A1453674 R77049 448212 755099_1 Al475858AW969013 451818 887271_1 Al819018 R0549ZW27615 453013 94390J AA031407N85751AW974119AA031408AA572965 455716 1352695_1 BE070263 BE070195 BE070265 BE070202 BE070233 BE070399 BE070203 457452 339381_1 AW972675M541366M523039 407305 312657 AA715284 TABLE 35C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers."Dunham, et al.'refers to the publication entiUed'The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 401539 8072433 Minus 62028-62608 402474 7547175 Minus 53526-53628, 55755-55920, 57530-57757 403549 8081591 Minus 137150-137362 403713 6573831 Minus 152769-153155 403790 8084957 Minus 87826-87947. 89835-90002 404176 9931122 Plus 52685-52800 405257 7329310 Plus 73121-73273

405475 1931025 Plus 1548-1702 TABLE 36A : ABOUT 169 GENES UP-REGULATED IN KIDNEY CANCER Table 36A lists about 169 genes up-regulated in kidney cancer compared to normal kidney that are likely to be extracellular or cell-surface proteins. These were selected as for Table 35A and the predicted protein contained a structural domain that is indicative of surface or extracellular localization (e. g. ig, fn3, egf. 7tm domains). Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tifle : Unigene gene 60e PSDomain : Protein Structural Domain RI : Rabo of lumor lo nommal Ussue Pkey ExAccn UnigenelD Unigene Title PSDomain R1 424704 AI263293 Hs. 152096 cytochrome P450 SS, p450 40. 9 426559 AB001914 Hs. 170414 paired basic am TM, Peptidase S8. P 35. 6 458079 Al796870 Hs. 54277 ESTs TM 34. 6 446921 AB012113 Hs. 16530 smali inducible SS, IL8 25. 9 452401 NM 007115 Hs. 29352 tumornecrosis TM, SS, Xlink, CUB 24. 8 414821 M63835 Hs. 77424 Fc fragment of TM, SS, ig 23. 4 414812 X72755 Hs. 77367 monokine induce SS. 1L8 22. 1 426471 M22440 Hs. 170009 transforming gr TM, SS, EGF 21. 3 449523 Nom-000579 Hs. 54443 chemokine (C-C TM, 7tm_1 20. 7 428227 AA321649 Hs. 2248 small inducible IL8 19. 5 456804 Al421645 Hs. 139851 caveolin 2 TM, Caveolin 17. 8 411642 NM014932 Hs. 71132 neuroligin 1 TM, SS, COesterase 16. 2 427581 NM 014788 Hs. 179703 KIAA0129 gene p TM 15. 6 448520 AB002367 Hs. 21355 doublecortin an TM, pkinase 14. 8 417308 H60720 Hs. 81892 KIAA0101 gene p TM 14. 8 421566 NM000399 Hs. 1395 early growth re TM, zf-C2H2 14. 6 422603 BE242587 Hs. 118651 hematopoietical TM, SS, homeobox 14. 4 425984 AW836277 Hs. 165636 hypothetical pr TM 14. 2 432606 NM 002104 Hs. 3066 granzyme K (ser TM, SS, trypsin 14. 1 458809 AW972512 Hs. 20985 sin3-associated SS 13. 7 446627 A1973016 Hs. 15725 hypothetical pr TM 13. 6 452960 AK001335 Hs. 31137 HomosapienscD TM, Y_phosphatase 13. 3 420552 AK000492 Hs. 98806 hypothetical pr TM. SS 13. 0 425188 AK002052 Hs. 155071 hypothetical pr TM 12. 6 419034 NM 002110 Hs. 89555 hemopoieticcel TM, pkinase, SH2, SH3 12. 3 442932 AA457211 Hs. 8858 bromodomain adj TM, bromodomain, PHD 12. 3 434398 AA121098 Hs. 3838 serum-inducible TM, pkinase, POLO box 12. 2 450506 Nom-004460 Hs. 418 fibroblast acti SS, DPPIV_N term, PepGdase_S9 12. 1 425782 U66468 Hs. 159525 cell growth reg SS 12. 0 426108 AA622037 Hs. 166468 programmedcell TM, DUF122 11. 9 450236 AW162998 Hs. 24684 KIM1376 protei TM, SS 11. 7 452838 U65011 Hs. 30743 preferentially TM 11. 2 426780 BE242284 Hs. 172199 adenylatecycla TM, guanylate_cyc 11. 1 415323 BE269352 Hs. 949 neutrophil cyto TM, SH3, TPR 11. 0 423508 AW604297 Hs. 129711 hepatitisAvir TM, SS, ig 11. 0 408380 AF123050 Hs. 44532 diubiquitin TM, ubiquitin, 7tm3, ANF receptor, sushi, 7tm1 11. 0 448410 AK000227 Hs. 21126 hypothetical pr TM 11. 0 451277 AK001123 Hs. 26176 hypothetical pr TM 10. 8 453165 S74727 Hs. 32042 aspartoacylase TM 10. 8 418036 Z37976 Hs. 83337 latenttransfor SS, TB, EGF 10. 5 431512 BE270734 Hs. 2795 lactate dehydro TM, Idh 10. 3 433862 D86960 Hs. 3610 KIAA0205 gene p TM, SS 10. 3 431211 M86849 Hs. 5566 gapjunctionpr TM, connexin 10. 2 432579 AF043244 Hs. 278439 nucleolar prote TM 10. 0 439653 AW021103 Hs. 6631 hypothetical pr TM, SS 9. 9 428862 NM000346 Hs. 2316 SRY (sex-determ TM, HMG box 9. 8 410762 AF226053 Hs. 66170 HSKM-B protein SS, zf-MYND 9. 8 452431 U88879 Hs. 29499 toll-like recep TM, SS. TIR, LRRCT 9. 5 405121 AB028989 Hs. 88500 mitogen-activat SS, vwa, vwd, TIL, Cys_knot, vwc 9. 5 449625 NM014253 Hs. 23796 odz (odd Oz/ten SH2, EGF 9. 4 421659 NM014459 Hs. 106511 protocadherini TM. SS. cacherin 9. 2 427283 AL119796 Hs. 174185 ectonucleotide TM, SS, Phosphodiest, Somatomedin_B 9. 1 407975 X89426 Hs. 41716 endothelial cel SS, IGFBP 8. 9 413554 AA319146 Hs. 75426 secretogranin I TM, SS, Granin 8. 6 418693 A1750878 Hs. 87409 thrombospondin EGF, TSPN, tsp_1, tsp_3, vwc 8. 6 437672 AW748265 Hs. 5741 flavohemoprotei TM, heme_1, oxidored tad, Cyt reductase 8. 6 430268 AK000737 Hs. 237480 hypothetical pr TM, SS 8. 5 447850 AB018298 Hs. 19822 SEC24 (S. cerev TM 8. 4 435717 AF227905 Hs. 105794 UDP-glucose : gly TM, Glyco transf 8 8. 3 433376 AI249361 Hs. 74122 caspase 4, apop TM, ICE_p20, cep10. CARD 8. 2 419490 NM006144 Hs. 90708 granzyme A (gra TM, SS, trypsin 8. 2 453033 AA325869 Hs. 31463 KIAA0281 gene p TM 8. 2 432328 Api572739 Hs. 195471 6-phosphofructo TM, 6PF2K, PGAM 7. 9 413719 BE439580 Hs. 75498 small inducible SS, IL8 7. 9 412448 L12964 Hs. 73895 tumornecrosis TM, SS, TNFR_c6 79 424247 X14008 Hs. 234734 lysozyme (renal SS, lys 7. 8 421991 NM014918 Hs. 110488 KIAA0990 protei SS 7. 8 400793 AA635062 Hs. 50094 Homo sapiens mR TM, BIR, CARD, zf-C3HC4 7. 7

414646 AA353776 Hs. 901 CD48 antigen (B TM, ig 7. 6 418372 AA311833 Hs. 84318 replication pro TM 7. 6 408418 AW963897 Hs. 44743 KIAA1435protei TM, W040, FYVE 7. 6 425354 U62027 Hs. 155935 complementcomp TM, 7tm_1 7, 5 432753 NM014075 Hs. 278915 PR00593 protein TM, pkinase 7. 4 447046 AA326187 Hs. 17170 G protein-coupl TM, 7tm1 7. 4 410577 X91911 Hs. 64639 glioma pathogen TM, SCP 7. 4 422631 BE218919 Hs. 118793 hypothetical TM 7. 3 417022 NM_014737 Hs. 80905 Ras association TM, RA 7. 2 430105 X70297 Hs. 2540 cholinergic rec TM, neur_chan 7. 2 451621 A1879148 Hs. 26770 fatty acid bind TM, SS, ipoca) in 7. 2 415138 C18356 Hs. 78045 tissue factor p Kunitz BPTI, G-gamma 7. 2 426028 NM 001110 Hs. 172028 a disintegrin a TM, SS, disintegrin, Reprolysin 7. 2 434096 AW662958 Hs. 75825 pleiomorphic ad TM, zf-C2H2 7. 1 426423 NM 012446 Hs. 169833 single-stranded TM 7. 1 412783 BE276738 Hs. 74578 DEAD/H (Asp-Glu TM, dsrm. helicastC 7. 1 431556 AF016028 Hs. 260039 sarcospan (Kras TM 6. 9 420018 U56387 Hs. 94376 proproteinconv TM, SS, Pep6dae S8, P 6. 9 444042 NM_004915 Hs. 10237 ATP-binding cas TM, ABC_tran 6. 9 432656 NM000246 Hs. 3076 MHC class 11 tr TM, LRR 6. 9 430066 Api929659 Hs. 237825 signa recognit TM, TPR 6. 9 401539 TM, SS, zf-B_box, zf-C3HC4, Lysyl_oxidae 6. 8 416058 L08895 Hs. 78995 MADS box transc TM, SRF-TF 6. 8 413249 AF167160 Hs. 75251 DEAD/H (Asp-Glu TM, SAP 6. 7 424063 NM002019 Hs. 138671 fms-related tyr TM, SS, pkinase, ig 6. 7 418026 BE379727 Hs. 83213 fatty acid bind TM, SS, lipocalin 6. 6 438619 AB032773 Hs. 6341 TU12B1-TYprote TM 6. 6 408741 M73720 Hs. 646 carboxypeptida SS, Zn_carbOpept, Propep_M14 6. 6 403549 TM, pkinase 6. 6 435798 BE395289 Hs. 12720 eIF4E-transport TM 6. 6 453070 AK001465 Hs. 31575 SEC63, endoplas TM, SS, DnaJ 6. 6 452092 BE245374 Hs. 27842 hypothetical pr TM, SS, Acyltransferase 6. 5 437396 BE140396 Hs. 21621 hypothetical pr TM 6. 4 402474 TM, Peptidase C1 6. 4 401600 BE247275 Hs. 151787 U5snRNP-specif TM, SS, HECT 6. 4 415076 NM000857 Hs. 77890 guanylate cycla TM, guanylate cyc 6. 4 430335 D80007 Hs. 239499 KiAA0185protei TM. S1 6. 3 434203 BE262677 Hs. 283558 hypothetical pr TM 6. 2 430287 AW182459 Hs. 125759 ESTs, Weakly si TM, SS 6. 2 417259 AW903838 Hs. 81800 chondroitin sul TM, Stink. lecUn_c, sushi, EGF, ig 6. 1 421202 AF193339 Hs. 102506 eukaryotictran TM, SS 6. 1 452235 AL039743 Hs. 28514 Homo sapiens mR TM 6. 0 429653 NM005955 Hs. 211581 metal-regulator TM, zf-C2H2 6. 0 444484 AK002126 Hs. 11260 hypothetical pr TM 5. 9 410193 AJ132592 Hs. 59757 zinc finger pro TM, zf-C2H2 5. 9 425361 AA355933 Hs. 132221 Homo sapiens cD TM 5. 9 410361 BE391804 Hs. 62661 guanylate bindi TM, SS, GBP 5. 8 415714 NM002290 Hs. 78672 laminin, alpha TM, SS, laminin_G, laminin_EGF 5. 8 421689 N87820 Hs. 106826 hypothetical pr TM, SS, PHD 5. 8 443837 Al984625 Hs. 9884 spindle pole bo SS 5. 8 422544 AB018259 Hs. 118140 KIAA0716 gene p TM 5. 7 412584 X54870 Hs. 74085 DNA segment on TM, lecUn_e 5. 7 410425 BE278367 Hs. 63510 KIAA0141 gene p TM 5. 7 426283 NM003937 Hs. 169139 kynureninase (L TM 5. 7 430440 X52599 Hs. 2561 nerve growth fa TM, SS, NGF 5. 7 413551 BE242639 Hs. 75425 ubiquitin assoc TM, SS, UBA 5. 7 418250 U29926 Hs. 83918 adenosine monop TM, A_deaminase 5. 6 419839 U24577 Hs. 93304 phospholipase A SS 5. 6 430253 AK001514 Hs. 236844 hypothetical pr TM 5. 6 450447 AF212223 Hs. 25010 hypothetical pr TM, ANF receptor, guanylate cyc, pkinase 5. 6 414020 NM002984 Hs. 75703 small inducible SS, ILB 5. 6 414844 M296874 Hs. 77494 deoxyguanosine SS, dNK 5. 6 416498 U33632 Hs. 79351 potassium chann TM 5. 6 430512 AF182294 Hs. 241578 U6 snRNA-associ SS 5. 6 419929 U90268 Hs. 93810 cerebralcavern SS, ank, Band 41 5. 5 407094 AF000574 Hs. 22405 leukocyte immun TM, SS, ig 5. 5 411653 AF070578 Hs. 71168 Homosapienscl TM, SS, Aa_trans 5. 5 452355 N54926 Hs. 29202 G protein-coupl TM, 7m 1 5. 5 440486 BE243513 Hs. 7212 hypothetical pr TM 5. 5 444825 AW167613 Hs. 248 mitogen-acUvat TM, SS, pkinase 5. 5 447072 D61594 Hs. 17279 tyrosylprotein SS 5. 4 453392 U23752 Hs. 32964 SRY (sex determ TM, HMG box 5. 4 411213 AA676939 Hs. 69285 neuropilinl TM, CUB, F5 F8 type C, MAM 5. 4 429688 BE245169 Hs. 211610 CUGtripletrep TM, rmm 5. 4 405257 TM 5. 4 414911 NM000107 Hs. 77602 damage-specific TM, WD40 5. 3 430598 AK001764 Hs. 247112 hypothetical pr TM 5. 3 428753 AW939252 Hs. 192927 hypothetica pr TM, SS 5. 3 406625 Y13647 Hs. 119597 stearoyl-CoAde TM, Desaturase 5. 3 405475 TM, sugartr 5. 3 430180 AA331406 Hs. 75456 A kinase (PRKA) TM 5. 3 417381 AF164142 Hs. 82042 sotutecarrier TM, xanurpermease 5. 3 433029 NM_014322 Hs. 279926 opsin3 (enceph TM, 7tm1 5. 3

417355 D13168 Hs. 82002 endothelin rece TM, SS, 7tm_l, zf-C3HC4 5. 3 412420 AL035668 Hs. 73853 bone morphogene SSTGFb_propepbdeeTGF-beta 5. 2 416975 NM004131 Hs. 1051 granzyme B (gra SS, trypsin 5. 2 451418 BE387790 Hs. 26369 hypothetical pr TM 5. 2 425322 U63630 Hs. 155637 protein kinase, TM, MCM, FAT. FATC. PI3_PI4_kinase 5. 2 415910 U20350 Hs. 78913 chemokine (C-X3 TM, 7tm_1 5. 2 428593 AW207440 Hs. 185973 degenerative sp TM 5. 2 417696 BE241624 Hs. 82401 CD69 antigen (p TM, lecUn_c 5. 2 442991 BE281238 Hs. 8886 hypothetical pr TM 5. 2 420567 AK000812 Hs. 98874 similar to pro ! TM 5. 1 412676 NM_000165 Hs. 74471 gap juncUon pr TM, connexin 5. 1 423430 AF112481 Hs. 128501 RAD54, S. cerev TM, SNF2_N, helicase_C 5. 1 421633 AF121860 Hs. 106260 sorting nexin 1 TM, PX 5. 1 436943 AA773838 Hs. 5353 caspase 10, apo TM, ICE plO, ICE_p20, DED 5. 1 414696 AF002020 Hs. 76918 Niemann-Pick di TM, SS, Patched 5. 1 446312 BE087853 gb : QV1-BT0681-2 TM 5. 0 420397 NM 007018 Hs. 97437 centrosomal pro TM 5. 0 410274 AA381807 Hs. 61762 hypoxia-inducib SS 5. 0 TABLE 36B' Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 446312 671114_1 BE087853 A1286184 TABLE 36C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al. * refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nu positon : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nu positon 401539 8072433 Minus 62028-62608 402474 7547175 Minus 53526-53628, 55755-55920, 57530-57757 403549 8081591 Minus 137150-137362 405257 7329310 Plus 73121-73273 405475 1931025 Plus 1548-1702 TABLE 37A : ABOUT 280 GENES DOWN-REGULATED IN KIDNEY CANCER Table 37A lists about 280 genes significantty down-regulated in kidney cancer compared to normal kidney These were selected as for Table 35A, except that the numerator and denominator were switched. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene fiHe RI : Ratio of normal to tumor tissue Pkey ExAccn UnigenelD UnigeneTitle RI 425260 L47726 Hs. 1870 phenylalanine hydroxylase 50. 20 445635 A1769774 Hs. 209831 ESTs, Weakly similar to ALU 1 _HUMAN ALU S 48. 14 440243 BE301029 Hs. 226422 ESTs 42. 54 431657 Api345227 Hs. 105448 ESTs, WeaklysimilartoB34087hypoUheb 40. 14 441120 A1632015 Hs. 164492 ESTs 34. 56 432488 AA551010 Hs. 216640 ESTs 33. 16 416854 H40164 Hs. 80296 Purkinje cell protein 4 32. 06 438452 AI220911 Hs. 288959 Homo sapiens cDNA : FLJ20920 fis, clone A 29. 54 414523 AU076633 Hs. 76353 serine (orcysteine) proteinaseinhibito 28. 26 430250 NM016929 Hs. 283021 chloride intracellular channel 5 28. 16 446795 Al797713 Hs. 156471 ESTs 27. 23 451949 U03884 Hs. 463 potassium inwardly-recUfying channel, s 26. 98 432128 AA127221 Hs. 117037 ESTs 26. 54 448178 A1479482 Hs. 170789 ESTs 25. 42 436639 D14838 Hs. 111 fibrobtast growth factor 9 (glia-activat 23. 99 426770 A1948618 Hs. 150178 ESTs 23. 78 428839 A1767756 Hs. 82302 ESTs 23. 04 431124 AF284221 Hs. 59506 doublesexandmab-3relatedtranscripUo 22. 38 413333 M74028 Hs. 75297 fibroblast growth factor 1 (acidic) 22. 28 437575 AW954355 Hs. 36529 ESTs 22. 14 451062 AL110125 Hs. 25910 Homo sapiens mRNA ; cDNA DKFZp564C1416 (f 22. 12 447350 A1375572 Hs. 172634 ESTs 20. 40 425920 AL049977 Hs. 162209 claudin 8 20. 30 446293 A1420213 Hs. 149722 ESTs 19. 48 425075 AA506324 Hs. 1852 acid phosphatase, prostate 19. 10 418318 U47732 Hs. 84072 transmembrane 4 superfamily member 3 18. 74 430130 AL137311 Hs. 234074 HomosapiensmRNA ; cDNADKFZp761G02121 (18. 56 441560 F13386 Hs. 7888 Homosapiensclone23736mRNAsequence 17. 40 434880 U02388 Hs. 101 cytochrome P450, subfamily IVF, polypept 17. 30 406667 M12523 Hs. 75442 albumin 17. 06 414602 AW630088 Hs. 76550 HomosapiensmRNA, cDNADKFZpS64B1264 ( 16. 54

418021 M15681 Hs. 1137 uromodulin (uromucoid, Tamm-Horsfaligly 16. 11 410681 AW246890 Hs. 65425 calbindin 1, (28kD) 15. 84 443324 R44013 Hs. 164225 ESTs 15. 68 421285 NM 000102 Hs. 1363 cytochrome P450, subfamily XVII (steroid 15. 46 436637 A1783629 Hs. 26766 ESTs 15. 18 448406 AW772298 Hs. 21103 Homo sapiens mRNA : cONA DKFZp564B076 (fr 14. 52 434874 N62448 Hs. 135906 ESTs 14. 46 407744 AB020629 Hs. 38095 ATP-binding cassette, sub-family A (ABC1 13. 84 453685 AL110309 gb : DKFZp564L0278r1 564 (synonym : hfbr2) 13. 48 451939 U80456 Hs. 27311 single-minded (Drosophila) homolog 2 13. 24 436624 T64297 Hs. 5241 fatty acid binding protein 1, liver 13. 05 428931 AA994979 Hs. 98967 ATPase, H (+transporting, lysosomal, no 12. 97 424823 NM_006226 Hs. 153322 phospholipase C, epsilon 12. 66 431713 AK000388 Hs. 267997 EHM2 gene 12. 66 436679 Al127483 Hs. 120451 ESTs, Weakly similar to unnamed protein 12. 36 413859 AW992356 Hs. 8364 pyruvate dehydrogenase kinase, isoenzyme 12. 32 425707 AF115402 Hs. 11713 E74-like factor 5 (ets domain transcript 11. 92 440504 Api948966 Hs. 130017 ESTs, Weakly similar to VATX_HUMAN VACUO 11. 66 417275 X63578 Hs. 81849 parvalbumin 11. 48 410929 H47233 Hs. 30643 ESTs 11. 40 427167 A1239607 Hs. 99196 ESTs 11. 34 445591 A1471866 Hs. 149095 ESTs 11. 30 443622 A1911527 Hs. 11805 ESTs 11. 23 438935 H40665 Hs. 31564 ESTs 11. 16 438461 AW075485 Hs. 286049 phosphoserine aminotransferase 11. 00 415539 A1733881 Hs. 72472 ESTs 10. 84 438081 H49546 Hs. 298964 ESTs 9. 76 421688 AK000307 Hs. 106825 hypothetical protein FU20300 9. 74 407280 A1241296 Hs. 145609 ESTs 9. 71 427969 NM_001963 Hs. 2230 epidermal growth factor (beta-urogastron 9. 61 442448 Al733144 Hs, 129611 ESTs 9. 52 442308 AA989402 Hs. 45194 ESTs 9. 51 410467 AF102546 Hs. 63931 dachshund (Drosophila) homolog 9. 35 429469 M64590 Hs. 27 glycine dehydrogenase (decarboxylating ; 9. 32 418068 AW971155 Hs. 293902 ESTs, Weakly similar to prolyl 4-hydroxy 9. 31 459247 N46243 Hs. 110373 ESTs 9. 20 423629 AW021173 Hs. 18612 HomosapienscDNA : FLJ21909 fis, clone H 9. 16 410247 AF181721 Hs. 61345 RU2S 9. 10 430573 AA744550 Hs. 136345 ESTs 9. 08 457411 AW085961 Hs. 130093 ESTs 8. 99 443790 NM 003500 Hs. 9795 acyl-Coenzyme A oxidase 2, branched chai 8. 92 435024 Api863518 Hs. 127743 ESTs, Weakly similar to V-ATPase -subun 8. 76 435056 AW023337 Hs. 5422 glycoprotein M6B 8. 74 426451 A1908165 Hs. 169946 GATA-binding protein 3 8. 50 450648 A1703366 Hs. 26766 ESTs 8. 38 426255 BE262530 Hs. 2006 glutathione S-transferase M3 (brain) 8. 31 431820 AW410408 Hs. 271167 L-pipecolic acid oxidase 8. 28 451027 AW519204 Hs. 40808 ESTs 8. 10 435823 R07856 Hs. 16355 ESTs 8. 06 429269 AA449013 Hs. 99203 ESTs 8. 02 438199 AW016531 Hs. 122147 ESTs 7. 94 442176 AA983764 Hs. 128910 ESTs 7. 94 450164 A1239923 Hs. 30098 ESTs 7. 86 445627 AW818475 Hs. 7363 ESTs 7. 85 445779 A1253104 Hs. 189267 ESTs 7. 82 407178 AA195651 Hs. 104106 ESTs 7. 68 426966 A1493134 Hs. 159125 ESTs 7. 68 445659 AW300508 Hs. 149229 ESTs 7. 50 403204 7. 46 448037 AW195634 Hs. 170401 ESTs 7. 30 413589 AW452631 Hs. 258811 coatomer protein complex, subunit gamma 7. 26 446063 A1720140 Hs. 151079 ESTs 7. 26 424626 AA344308 Hs. 128427 ESTs 7. 25 403381 7. 16 414807 A1738616 Hs. 77348 hydroxyprostaglandin dehydrogenase 15- (N 7. 12 432102 AW015506 Hs. 130730 ESTs 7. 12 442315 AA173992 Hs. 7956 ESTs 7. 10 453698 AA037615 Hs. 42746 ESTs 7. 02 415003 M11437 Hs. 77741 kininogen 6. 95 426418 M90464 Hs. 169825 collagen, type IV, aipha 5 (AJport syndr 6. 92 452883 X80031 Hs. 150318 ESTs 6. 88 408621 Api970672 Hs. 46638 chromosome 11 open reading frame 8 6. 76 410781 A1375672 Hs. 165028 ESTs 6. 74 424596 AB020639 Hs. 151017 estrogen-relatedreceptorgamma 6. 66 441031 AI110684 Hs. 7645 fibrinogen, B beta polypeptide 6. 66 451099 R52795 Hs. 25954 intedeukin 13 receptor, alpha 2 6. 64 437553 A1829935 Hs. 130497 ESTs, Weakly similar to MAT8_HUMAN CHLOR 6. 63 445286 U03886 Hs. 264 GS2 gene 6. 54 408427 AW194270 Hs. 177236 ESTs 6. 52 410442 X73424 Hs. 63788 propionyl Coenzyme A carboxylase, beta p 6. 46 457001 J03258 Hs. 2062 vitamin D (1, 25-dihydroxyvitamin D3) re 6. 46 420205 AA256395 Hs. 88156 ESTs 6. 42 441364 AW450466 Hs. 126830 ESTs 6. 36

425649 U30930 Hs. 158540 UDPglycosyltranslerase8 (UDP-gåætose 6. 34 405373 6. 32 431322 AW970622 gb : EST382704 MAGE resequences, MAGK Homo 6. 32 440094 A1651558 Hs. 270372 ESTs 6. 27 442764 A1762254 Hs. 131122 ESTs 6. 21 424433 H04607 Hs. 9218 ESTs 6. 20 415025 AW207091 Hs. 72307 ESTs 6. 16 428927 AA441837 Hs. 90250 ESTs 6. 16 439145 H67346 Hs. 269187 ESTs 6. 06 424683 N87519 Hs. 27196 ESTs 6. 04 415314 N88802 Hs. 5422 glycoprotein M6B 5. 94 424025 Al701852 Hs. 301296 ESTs 5. 90 445911 A1985987 Hs. 145645 ESTs, Moderately similar to ALU1_HUMAN A 5. 89 417332 AW972717 Hs. 288462 HomosapienscDNA : FLJ21511 fis, clone C 5. 86 440102 A1672443 Hs. 131190 ESTs 5. 84 429609 AF002246 Hs. 210863 cell adhesion molecule with homology to 5. 82 411666 AF106564 Hs. 71346 neurofilament3 (150kD medium) 5. 82 446224 AW450551 Hs. 13308 ESTs 5. 74 422305 A1928242 Hs. 293438 ESTs, Highly similar to AFi984881 Uans 5. 72 436802 N34486 Hs. 170504 ESTs 5. 72 412452 AA215731 Hs. 283446 ESTs, Weakly similar to ALAT_HUMAN ALANI 5. 70 445611 AW418497 Hs. 145583 ESTs 5. 66 440038 AA861627 Hs. 243989 ESTs 5. 66 424028 AF055084 Hs. 153692 KIAA0686 protein 5. 61 410530 M25809 Hs. 64173 ESTs. HighlysimilartoVAB1_HUMANVACU0 5. 60 425907 AA365752 Hs. 155965 ESTs 5. 60 428523 AW974540 Hs. 98626 ESTs 5. 58 429918 AW873986 Hs. 119383 ESTs 5. 58 408369 R38438 Hs. 182575 solutecamerfamily15 (H/pepUdetra 5. 56 446163 AA026880 Hs. 25252 Homo sapiens cDNA FLJ13603 fis, clone PL 5. 56 427398 AW390020 Hs. 20415 chromosome 21 open reading frame 11 5. 52 418504 BE159718 Hs. 85335 Homo sapiens mRNA ; cDNA DKFZp56401462 (f 5. 51 440666 AA902650 Hs. 192742 Homo sapiens EDNA FU 12785 fis, clone NT 5. 50 432286 AW327432 Hs. 255843 ESTs 5. 48 451236 AI767406 Hs. 207026 ESTs, Weakly similar to B56205 transcrip 5. 46 422746 NM004484 Hs. 119651 glypican 3 5. 43 416426 AA180256 Hs. 210473 ESTs, Weakly similar to GELSHUMANGELSO 5. 37 414449 AA557660 Hs. 76152 decorin 5. 36 445898 AF070623 Hs. 13423 Homo sapiens clone 24468 mRNA sequence 5. 34 451835 T63643 Hs. 209715 ESTs, Weakly similar to ALU7 HUMAN ALU S 5. 32 424566 M16801 Hs. 1790 nuclear receptor subfamily 3, group C, m 5. 22 408604 D51408 Hs. 21925 ESTs 5. 18 456576 AA287443 gb : zs52c10. rl NCI_CGAP_GCB1 Homosapiens 5. 18 433212 BE218049 Hs. 121820 ESTs 5. 16 452114 N22687 Hs. 8236 ESTs 5. 14 458072 AI890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 5. 14 443005 A1027184 Hs. 200918 ESTs 5. 14 408554 AA836381 Hs. 7323 ESTs 5. 12 438609 T62870 Hs. 291991 ESTs 5. 10 429343 AK000785 Hs. 199480 epsin 3 5. 10 452223 AA425467 Hs. 8035 ESTs 5. 10 446925 AW974605 Hs. 176669 ESTs 5. 09 407664 AW063476 Hs. 279080 ESTs 5. 08 414664 AA587775 Hs. 66295 Homo sapiens HSPC311 mRNA, partial cds 5. 06 407978 AW385129 Hs. 41717 phosphodiesterase 1A, calmodulin-depende 5. 04 435343 AW194962 Hs. 199028 ESTs 5. 04 419150 T29618 Hs. 89640 TEK tyrosine kinase, endothelial (venous 5. 04 442317 A1915599 Hs. 129225 ESTs 5. 02 404319 5. 02 433637 AW024214 Hs. 135405 ESTs 4. 92 440205 T86950 Hs. 188465 ESTs 4. 84 432029 D31628 Hs. 2899 4-hydroxyphenylpyruvate dioxygenase 4. 83 453125 AW779544 Hs. 115497 Homo sapiens cDNA : FLJ22655 fis, clone H 4. 80 407788 BE514982 Hs. 38991 S100 calcium-binding protein A2 4. 78 439750 AL359053 Hs. 57664 Homo sapiens mRNA full length insert cDN 4. 75 443633 AL031290 Hs. 9654 similar to pregnancy-associated plasma p 4. 74 449050 AW302858 Hs. 187333 ESTs 4. 69 422237 M13149 Hs. 1498 histidine-rich glycoprotein 4. 67 442476 AF069475 gb : AF069475 Homo sapiens astrocytoma lib 4. 64 431130 NM 006103 Hs. 2719 epididymis-specific. whey-acidic protein 4. 58 440624 AF017987 Hs. 7306 secreted frizzled-related protein 1 4. 58 403046 4. 51 450838 R65841 Hs. 28653 ESTs 4. 48 455887 BE154173 gb : PM1-HT0340-201299 00412 HT0340 Homo 4. 47 453500 A1478427 Hs. 43125 ESTs 4. 40 405701 4. 37 426657 NM 015865 Hs. 171731 solute camer family 14 (urea transport 4. 37 451032 W03692 Hs. 25832 Homo sapiens mRNA ; cDNA DKFZp564P116 (fr 4. 37 426200 AA371876 Hs. 234786 KIAA0707 protein 4. 35 418836 A1655499 Hs. 161712 ESTs 4. 34 447754 AW073310 Hs. 163533 Homo sapiens cDNA FW14142 hs, clone MA 4. 32 438209 AL120659 Hs. 6111 KIAA0307 gene product 4. 23 404559 4. 22

413272 AA127923 Hs. 293256 ESTs 4. 21 423068 M25629 Hs. 123107 kallikrein 1, renal/pancreas/salivary 4. 19 416982 J05401 Hs. 80691 creatine kinase, mitochondrial 2 (sarcom 4. 18 445512 A1241246 Hs. 148903 EST 4. 17 445177 A1215070 Hs. 16135 ESTs 4. 16 448475 BE613134 Hs. 247474 HomosapienscDNA : FU21032 fis, clone C 4. 14 402072 4. 09 439285 AL133916 Hs. 298998 ESTs 4. 02 429621 Api823386 Hs. 130874 Homo sapiens cDNA FW14181 hs, clone NT 3. 99 450273 AW296454 Hs. 24743 hypothetical protein FW20171 3. 97 453511 AL031224 Hs. 33102 transcriptionfactorAP-2beta (aetivati 3. 94 452620 AA436504 Hs. 119286 ESTs 3. 92 425642 X91220 Hs. 158462 solutecarierfamily12 (sodium/chlond 3. 91 435884 AA701443 Hs. 192868 ESTs 3. 90 416889 AW250318 Hs. 80395 mal, T-cell differentiation protein 3. 89 419677 N77342 Hs. 21851 Homo sapiens cDNA FLJ12900 fis, clone NT 3. 88 431958 X63629 Hs. 2877 cadherin 3, lype 1, P-cadhen (placenta 3. 84 456844 A1264155 Hs. 152981 CDP-diacylglycerol synthase (phosphabda 3. 82 442306 A1820660 Hs. 129205 ESTs 3. 82 438453 D17056 Hs. 288959 Homo sapiens cDNA : FU20920 fis, clone A 3. 81 407198 H91679 gb : yvO4aO7. slSoaresfetalliverspleen 3. 80 431441 U81961 Hs. 2794 sodium channel, nonvoltage-gated 1 alpha 3. 79 413841 M34276 Hs. 75576 plasminogen 3. 77 431161 AA493591 gb : nhOlal2. s1 NCl_CGAP_Thyl Homo sapiens 3. 76 428544 AA430034 Hs. 191611 ESTs 3. 74 453903 AW299606 Hs. 232777 ESTs 3. 74 434061 AW024973 Hs. 283675 NPD009 protein 3. 73 444805 AB007899 Hs. 12017 KIAA0439 protein ; homolog of yeast ubiqu 3. 73 440080 AW051597 Hs. 143707 ESTs 3. 71 440230 A1732970 Hs. 126246 ESTs 3. 70 428735 AJ279246 Hs. 192657 NPHS2gene (podocin) 3. 68 421832 NM016098 Hs. 108725 HSPC040 protein 3. 66 430135 NM000035 Hs. 234234 aldolase B, fructose-bisphosphate 3. 65 453055 AW291436 Hs. 31917 ESTs 3. 65 450696 A1654223 Hs. 16026 Homo sapiens cDNA : FLJ23191 fis, clone L 3. 59 440232 A1766925 Hs. 112554 ESTs 3. 57 432099 U20760 Hs. 272429 calcium-sensing receptor (hypocalciuric 3. 57 445924 A1264671 Hs. 164166 ESTs 3. 56 411356 H45377 gb : yn99hO3. r1SoaresadultbrainN2b5HB5 3. 56 431103 M57399 Hs. 44 pleiobrophin (heparin binding growth fac 3. 55 413752 BE161807 gb : MRHT044&300300-203-h01 HT0446 Homo 3. 53 416298 NM003891 Hs. 1011 proteinZ, vitaminK-dependentplamagl 3. 53 423603 AB007880 Hs. 129883 KIAA0420 gene product 3. 53 436610 AW611912 Hs. 120414 ESTs 3. 50 425905 AB032959 Hs. 161700 KIAA1133 protein 3. 48 403625 3. 47 425210 AA054679 Hs. 155150 ribonuclease P (14kD) 3. 45 430168 AW968343 Hs. 300896 ESTs, HighlysimilartoAF1281131promi 3. 42 448877 A1583696 Hs. 253313 ESTs 3. 40 456686 Al554303 Hs. 35982 Homo sapiens cDNA FLJ 12776 fis, clone NT 3. 38 414725 AA769791 Hs. 120355 Homo sapiens CDNA FU13148 fis, clone NT 3. 37 453574 Al767947 Hs. 50841 ESTs, Weakly similar to tuftelin [M. musc 3. 32 438535 L09078 gb : Homo sapiens mRNA fragment 3. 31 414040 N58513 Hs. 32171 ESTs 3. 30 451416 AW631469 Hs. 203213 ESTs 3. 30 444564 Al 167877 Hs. 143716 ESTs 3. 29 408001 AA046458 Hs. 95296 ESTs 3. 27 406666 V00495 Hs. 75442 albumin 3. 24 421750 AK000768 Hs. 107872 hypothetical protein FU20761 3. 24 445337 NM_013280 Hs. 12523 fibronectin leucine rich transmembrane p 3. 23 423968 AF098277 Hs. 136529 solutecanierfamily23 (nucleobasetra 3. 21 427209 H06509 Hs. 92423 KIAA1566 protein 3. 20 403442 3. 20 419713 AW968058 Hs. 92381 nudix (nucleoside diphosphate linked moi 3. 19 425548 AA890023 Hs. 1906 prolæUn receptor 3. 17 414502 AL133721 Hs. 224680 ESTs 3. 16 427811 M81057 Hs. 180884 catboxypeptidase 81 (tissue) 3. 14 436330 NM 004413 Hs. 109 dipeptidasel (renai) 3. 11 433942 AW272166 Hs. 123465 ESTs 3. 11 408692 AL040127 Hs. 34074 dipepbdylpepfidase VI 3. 10 448819 A1589190 Hs. 188372 ESTs 3. 10 423041 BE170842 Hs. 123123 chloridechannelKa 3. 10 454554 AW847505 gb : RCO-CT0210-280999-021-clO CT0210 Homo 3. 10 406664 L34041 Hs. 25478 glycerol-3-phosphate dehydrogenase 1 (so 3. 10 449850 AW206292 Hs. 199751 ESTs 3. 08 427450 AB014526 Hs. 178121 KIAA0626 gene product 3. 08 454788 AW820691 gb : RC5-ST0300-300100-012-HO6 ST0300 Homo 3. 06 444895 A1674383 Hs. 301192 ESTs 3. 06 457782 N54493 gb : yv40gO5. s1 Scares fetal liver spleen 3. 05 429023 NM000312 Hs. 2351 protein Cpnactivator of coagulation fa 3. 05 427041 A1693661 Hs. 97557 ESTs 3. 01 434788 AF154121 Hs. 102867 sodium-dependent high-affinity dicarboxy 3. 01 419003 T78640 Hs. 268595 ESTs 3. 01

TABLE 37B : Pkey : Unique Eos probeset identifier number CAT number. Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 411356 1240273 1 H45377 H21137 AW838640 413752 1386338 1 BE161807 BE161584 BE161700 BE161748 431161 3287131 AA493591AA829120AA533792 431322 331543 1 AW970622 AA503009 AA502998 AA502989AA502805T92188 438535 45946 1 L09078 L03145 L09094 L09098 L03165 L09102 442476 543547 1 AF069475 AF069477 AF069476 453685 977734 1 AL110309 AW083119 H22881 454554 1223842_1 AW847505 AW811792 BE061442 BE061433 AW847506 AW806999AW806996 BE061436 BE061430 BE142460 BE146499 AW806994 AW809156 AW806991 AW814082 AW806992 BE061669 AW807002 BE146659 AW806995 AW807000 AW845743 AW845747 AW847504 BE142458 BE061431 BE061435 AW847507 BE146650 BE142470 AW814096 AW807012 BE061438 AW807011 AW806993 BE142465 BE142459 BE142462 AW854330 AW854331 BE061434 BE061731 BE142464 AW847501 AW807001 BE142463 AW811800 BE061437 AW811802 BE061440 AW806997 AW806998 BE061745 BE061753 454788 1234694-1 AW820691 455887 1380836_1 BE154173 BE154098 BE154096 456576 201378 1 AA287443 AA419385 BE084078 A1478347 457782 405265_1 N54493 AA679039 N76605 407198 H91679 TABLE 37C : Pkey : Unique Eos probeset identifier number Ref : reference gi ID Strand : strand identification Position : chromosomal nucleofide position Pkey Ref Strand Position 402072 8117363 Plus 71983-72128 403046 3540153 Minus 55707-55859, 56369-56511 403204 7622392 Plus 16214-16439 403381 9438267 Minus 26009-26178 403442 7210003 Plus 174560-175270 403625 8569879 Plus 6551-7111 404319 9211467 Plus 54436-54608 404559 8748893 Minus 734973651, 89575-89739 405373 2076718 Plus 21294-21575 405701 4263751 Plus 93243-93364 TABLE 38A ABOUT 860 GENES UP-REGULATED IN KIDNEY CANCER COMPARED TO NORMAL ADULT TISSUES Table 38A lists about 860 genes up-regulated in kidney cancer compared to normal adult tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the ratio of'average'kidney cancer to *average'normal adult tissues was greater than or equal to 3. 0. The'average'kidney cancer level was set to the 90th percentile amongst various kidney cancers. The'average'normai adult Ussue level was set to the 70th percentite amongst various non-malignant tissues. In order to remove gene- specific background levels of non-specific hybridization, the 15th percentile value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tide : Unigene gene 60e R1 : Ratio of tumor to normal adult tissues Pkey ExAccn UnigenelD Unigene Title R1 435013 H91923 Hs. 110024 15. 71 447768 X86400 Hs. 19520 Hs. 19520 : FXYD domain-containing ion tran 14. 07 445178 A1792241 Hs. 129614 Hs. 129614 : kidney-specific membrane prote 12. 56 432542 AW083920 Hs. 16098 Hs. 16098 : claudin 2 12. 41 443595 AF169312 Hs. 9613 NM_016109 : Homo sapiens angiopoietin-like 11. 77 413719 BE439580 Hs. 75498 NM 004591 : Homo sapiens small inducible c 10. 39 436878 BE465204 Hs. 47448 Hs. 47448 : ESTs 10. 18 440304 BE159984 Hs. 125395 Hs. 125395 : ESTs 9. 95 407065 Y10141 9. 58 413049 NM 002151 Hs. 823 NM 002151 : Homo sapiens hepsinftransmemb 9. 51 425983 AK000226 Hs. 165619 Hs. 165619 : mucinandcadherin-like 8. 88 423161 AL049227 Hs. 124776 Hs. 124776 : HomosapiensmR ; cDDKFZpS64N1 8. 77 430569 AF241254 Hs. 178098 Hs. 178098 : angiotensin I converting enzym 8. 45 416768 AA363733 Hs. 1032 NM002909 : Homo sapiens regenerating isle 7. 94 422357 AF016272 Hs. 115418 NM004062 : Homosapienscadherin 16, KSP-7. 78 420737 L08096 Hs. 99899 NM 001252 : Homo sapiens tumor necrosis fa 7. 78 409745 AA077391 AA077391 : 7B14E12 Chromosome 7 Fetal Brai 7. 74 413936 AF113676 Hs. 297681 NM000295 : Homo sapiens serine (or cystei 7. 32 426682 AV660038 Hs. 2056 Hs. 2056 : UDP glycosyltransferase 1 family 7. 20 406851 AA609784 Hs. 352392 Hs. 352392 : major histocompatibility compi 7. 03 419508 AW997938 Hs. 90786 Hs. 90786 : ATP-binding cassette, sub-famil 6. 57 428953 AA306610 Hs. 348183 NM003823 : Homo sapiens tumor necrosis fa 6. 36 436895 AF037335 Hs. 5338 NM001218 : Homo sapiens carbonic anhydras 6. 31 431842 NM 005764 Hs. 271473 NM_005764 : Homo sapiens epithelial protei 6. 20 430014 H59354 Hs. 374303 Hs. 374303 : hypothetical protein MGC20576 6. 20 423803 NM005709 Hs. 132945 NM 005709 : Homo sapiens PDZ-73 protein (P 6. 19

434779 AF153815 Hs. 50151 Hs. 50151 : potassium inwardly-rectifying c 6. 11 435767 H73505 Hs. 117874 Hs. 117874 : ESTs 6. 08 422664 AA315933 Hs. 120879 Ho. 120879 : Homo sapiens, done MGC : 32871 6. 02 425280 U31519 Hs. 1872 Hs. 1872 : phosphoenolpyruvatecarboxykise 5. 81 426559 AB001914 Hs. 170414 Nom002570 : Homo sapiens paired basic amin 5. 73 451564 AU076698 Hs. 132760 NM001467 : Homo sapiens glucose-&phospha 5. 69 418526 BE019020 Hs. 85838 NM_004207 : Homo sapiens solute carrier fa 5. 68 444151 AW972917 Hs. 128749 Hs. 128749 : alphamethylacyl-CoAracemase 5. 66 426471 M22440 Hs. 170009 NM_003236 : Homo sapiens transforming grow 5. 48 432579 AF043244 Hs. 278439 NM 003946 : Homo sapiens nucleolar protein 5. 45 448733 NM5629 Hs. 187958 NM005629 : Homo sapiens solute carrier fa 5. 42 446650 AB016625 Hs. 15813 NM_003060 : Homo sapiens solute carrier fa 5. 36 417089 H52280 Hs. 18612 Hs. 18612 : HomosapienscaFU21gO9fis 5, 35 437848 Api906419 Hs. 284380 Hs. 284380 : gamma-glutamyltransferase 1 5. 32 423081 AF262992 Hs. 123159 Hs. 123159 : sperm associated antigen 4 5. 30 421893 NM 001078 Hs. 109225 NM001078 : Homo sapiens vascular cell adh 5. 23 435886 BE265839 Hs. 12126 Hs. 12126 : hepatocellularcarcinoma-associ 5. 20 410276 A ! 554545 Hs. 359201 Hs. 359201 : ESTs 5. 20 429451 BE409861 Hs. 202833 NM_002133 : Homo sapiens heme oxygese (dec 5. 14 446404 AA019961 Hs. 26216 Hs. 26216 : Homo sapiens cD : FLJ22811 fis, 5. 13 423445 NM 014324 Hs. 128749 NM_014324 : Homo sapiens alpha-methylacyl-5. 09 449444 AW818436 Hs. 351306 NM_004696 : Homo sapiens solute carrier fa 5. 05 438106 BE245551 Hs. 6079 NM014863 : Homo sapiens B cell RAG associ 5. 02 400419 AF084545 AF084545 : Homo sapiens versican Vint isof 5. 01 453920 Al133148 Hs. 36602 NM 000204 : Homo sapiens I factor (complem 4. 99 447881 BE620886 Hs. 355279 Hs. 355279 : Homo sapiens cD FLJ23711 fis, 4. 97 422253 W81526 Hs. 113882 NM000815 : Homosapiensgamma-aminobutyn 4. 93 439024 R96696 Hs. 35598 Hs. 35598 : ESTs 4. 88 414799 Api752416 Hs. 77326 NM000598 : Homo sapiens insulin-like grow 4. 80 426530 U24578 Hs. 278625 NM_000592 : Homo sapiens complement compon 4. 77 410055 AJ250839 Hs. 58241 Hs. 58241 : geneforsenne/threonineprote 4. 72 404240 4. 71 414617 A1339520 Hs. 288817 Hs. 288817 : hypothetical protein FLJ22761 4. 68 448249 AW855331 Hs. 337124 Hs. 337124 : ESTs 4. 67 447818 W79940 Hs. 21906 Hs. 21906 : Homo sapiens clone 24670 mR seq 4. 66 449057 AB037784 Hs. 22941 Hs. 22941 : KIAA1363 protein 4. 66 422424 A1186431 Hs. 296638 NM 004864 : Homo sapiens prostate differen 4. 62 417336 R70429 Hs. 81988 NM 001343Homo sapiens disabled homolog 4. 62 425873 NM_013390 Hs. 160417 NM013390 : Homo sapiens transmembrane pro 4. 58 444700 Nom003645 Hs. 11729 NM_003645 : Homo sapiens fatty-acid-Coenzy 4. 58 414998 NM 002543 Hs. 77729 NM002543 : Homo sapiens oxidised low dens 4. 56 414763 U97276 Hs. 77266 NM_002826 : HomosapiensquiescinQ6 (QSCN 4. 48 443358 H65417 Hs. 17757 Hs. 17757 : pieckstrin homology domain-cont 4. 45 440091 A1767388 Hs. 37890 Hs. 37890 : Homo sapiens, clone IMAGE : 48275 4. 43 447131 NM_004585 Hs. 17466 NM004585 : Homo sapiens reGnoic acid rec 4. 43 406973 M34996 Hs. 198253 Hs. 198253 : maiorhistocompatibi) itycomp) 4. 42 427740 BE242604 Hs. 180616 NM_005505 : Homo sapiens CD36 antigen (col 4. 40 436258 AW867491 Hs. 107125 Hs. 107125 : plasmalemma vesicle associated 4. 38 452884 C05964 Hs. 31841 Hs. 31841 : ESTs 4. 37 444006 BE395085 Hs. 10086 NM016639 : Homo sapiens type I transmembr 4. 36 422627 BE336857 Hs. 118787 NM 000358 : Homo sapiens transforming grow 4. 35 418054 NM 002318 Hs. 83354 NM002318 : Homosapienslysyloxidase-lik 4. 34 419011 H56244 Hs. 89552 NM_000846 : Homo sapiens glutathione Stra 4. 34 404277 4. 33 435563 AF210317 Hs. 95497 Hs. 95497 : solute carrier family 2 (faciii 4. 30 431779 AW971178 Hs. 268571 NM_001645 : HomosapiensapolipopnoteinC-4. 29 406645 M57466 Hs. 814 Hs. 814 : majorhistocompatibilitycomplex, 4. 28 421485 AA243499 Hs. 104800 Hs. 104800 : hypothetical protein FLJ10134 4. 26 426812 AF105365 Hs. 172613 NM006598 : Homo sapiens solute carrier fa 4. 25 407910 AA650274 Hs. 41296 NM_013281 : Homo sapiens fibronectin leuci 4. 22 438030 X98427 Hs. 122634 Hs. 122634 : ESTs 4. 22 430661 AC005551 Hs. 130714 Hs. 130714 : ESTs, Moderately similar to AF 4. 21 444381 BE387335 Hs. 283713 Hs. 283713 : hypoSheUcaproteinBC014245 4. 20 438203 BE540090 Hs. 7345 Hs. 7345 : MAD1 mitotic arrest deficient-li 4. 16 411358 R47479 Hs. 94761 Hs. 94761 : KIAA1691 protein. 4. 15 418323 NM 002118 Hs. 1162 NM 002118 : Homosapiensmajorhistocompat 4. 12 449853 AF006823 Hs. 24040 NM002246 : Homo sapiens potassium channel 4. 11 415198 AW009480 Hs. 943 NM 004221 : Homosapiensturakillercell 4. 11 418751 BE389014 Hs. 372548 Hs. 372548 : phosphoinosiXde-3-kise, regul 4. 09 414166 AW888941 Hs. 75789 NM 006096 : HomosapiensN-mycdownstream 4. 07 424125 M31669 Hs. 1735 Hs. 1735 : inhibin, beta B (activin AB beta 4. 00 416926 H03109 Hs. 263395 Hs. 263395 : sema domain, transmembranedom 3. 92 419175 AW270037 Hs. 362996 Hs. 362996 : KIAA0779 protein 3. 92 424218 AF031824 Hs. 143212 NM003650 : Homo sapiens cystabn F (leuko 3. 91 412870 N22788 Hs. 82407 Hs. 82407 : chemokine (C-X-CmoUfjligand 3. 88 452203 X57522 Hs. 352018 NM000593 : Homo sapiens transporter 1. AT 3. 87 446872 X97058 Hs. 16362 NM 004154 : Homo sapiens pyrimidinergic re 3. 87 449961 AW265634 Hs. 133100 Hs. 133100 : ESTs 3. 87 424517 Al539443 Hs. 137447 Hs. 137447 : Homo sapiens c0 FLJ12169 fis, 3. 86 425262 D87119 Hs. 155418 Hs. 155418 : GS3955 protein 3. 83 443639 BE269042 Hs. 9661 NM_002801 : Homo sapiens proteasome (proso 3. 82 448133 AA723157 Hs. 73769 Nu000802 : Homo sapiens folate receptor 1 3. 81 418030 BE207573 Hs. 83321 Hs. 83321 : neuromedin B 3. 81

412939 AW411491 Hs. 75069 NM-00541ZHomo sapiens sedne hydroxymet 3. 80 409162 H25530 Hs. 50868 NM 002555 : Homo sapiens solute carder fa 3. 79 427715 BE245274 Hs. 180428 Hs. 180428 : KIAA1181 protein 3. 78 412006 AW451618 Hs. 290216 Hs. 290216 : ESTs 3. 77 430413 AW842182 Hs. 241392 NM_002985 : Homo sapiens small inducible c 3. 76 422282 AF019225 Hs. 114309 Hs. 114309 : apolipoproteinL, 1 3. 76 420747 BE294407 Hs. 99910 Hs. 99910 : phosphofructokise, platelet 3. 76 414875 H42679 Hs. 77522 NM006120 : Homo sapiens major histocompat 3. 75 418793 AW382987 Hs. 88474 Hs. 88474 : prostaglandin-endoperoxide synt 3. 74 446291 BE397753 Hs. 14623 NM 006332 : Homo sapiens interferon, gamma 3. 71 417289 D86962 Hs. 81875 Hs. 81875 : growth factor receptor-bound pr 3. 69 422672 X12784 Hs. 119129 NM001845 : Homo sapiens collagen, type IV 3. 68 448569 BE382657 Hs. 21486 NM007315 : Homo sapiens sigl transducer a 3. 68 437270 R18087 Hs. 323769 Hs. 323769 : cisplatin resistance related p 3. 67 408452 AA054683 Hs. 192455 Hs. 192455 : ESTs, Moderately similar to hy 3. 67 443986 Ai381750 Hs. 283437 Hs. 283437 : HTGN29 protein 3. 66 418869 AW516565 AW516565 : xqOldO5. xl Soares_NHCeC_cervica 3. 65 425998 AU076629 Hs. 165950 NM_002011 : Homosapienshbroblastgrowth 3. 62 428699 AW578252 Hs. 190161 NM014020 : Homo sapiens LR8 protein (LR8) 3. 62 418299 AA279530 Hs. 83968 NM 000211 : Homo sapiens integrin, beta 2 3. 61 432593 AW301003 Hs. 51483 Hs. 51483 : Homo sapiens, Similar to RIKEN 3. 59 415765 Nom005424 Hs. 78824 Nom005424 : Homo sapiens tyrosine kise wit 3. 58 445985 BE621800 Hs. 29444 Hs. 29444 : putative small membrane protein 3. 57 424893 AW295112 Hs. 153648 Hs. 153648 : protein tyrosine phosphatase, 3. 57 426046 AA833655 Hs. 206868 Hs. 206868 : Homo sapiens cD FU14056 fis, 3. 57 424415 NM001975 Hs. 146580 NM_001975 : Homosapiensenolae2, (gamma 3. 57 412612 NM000047 Hs. 74131 NM000047 : Homo sapiens arylsulfatase E 3. 56 443834 A1741510 Hs. 173548 Hs. 173548 : ESTs 3. 54 431630 NM002204 Hs. 265829 NM002204 : Homo sapiens integrin, alpha 3 3. 53 418371 M13560 Hs. 84298 Hs. 84298 : CD74 antigen (invariant polypep 3. 52 444838 AV651680 Hs. 208558 Hs. 208558 : ESTs 3. 52 449378 AW664026 Hs. 59892 Hs. 59892 : ESTs, Weakly similar to alpha 5 3. 52 411393 AW797437 Hs. 69771 NM001710 : Homo sapiens B-factor, properd 3. 50 414311 AI693547 Hs. 71746 Hs. 71746 : aminopeplidaseiikel 3. 50 415149 X12451 Hs. 78056 NM_001912 : Homo sapiens cathepsin L (CTSL 3. 50 424321 W74048 Hs. 1765 Hs. 1 765 : lymphocyte-specific protein tyro 3. 49 414825 X06370 Hs. 77432 Nom-005228 : Homo sapiens epidermal growth 3. 48 408194 AA601038 Hs. 191797 Hs. 191797 : ESTs 3. 48 410600 AW575742 Hs. 351676 Hs. 351676 : ESTs, Weakly similar to T02670 3. 47 416899 BE262645 Hs. 80420 NM 002996 : Homo sapiens small inducible c 3. 47 436856 Api469355 Hs. 127310 Hs. 127310 : hypothefical protein BC014917 3. 47 419660 BE280337 Hs. 194693 NM 003982 : Homo sapiens solute carrier fa 3. 47 413566 AW604451 Hs. 285814 Hs. 285814 : growth factor receptor-bound p 3. 47 412104 AW205197 Hs. 240951 Hs. 240951 : ked cuticle homolog 2 (Drosoph 3. 46 444488 AW192879 Hs. 355660 Hs. 355660 : peptide-histidine transporter 3. 46 449475 A1348027 Hs. 108557 Hs. 108557 : hypotheUcal protein PP1057 3. 46 412276 BE262621 Hs. 73798 NM 002415 : Homo sapiens macrophage migrat 3. 45 449338 H73444 Hs. 394 NM001124 : Homo sapiens adrenomedullin (A 3. 44 430304 AL122071 Hs. 238927 Hs. 238927 : Homo sapiens mR cD DKFZp434H1 3. 43 415388 AF018081 Hs. 78409 (locuslink) NM_030582 : Homo sapiens coliag 3. 43 432210 A1567421 Hs. 273330 Hs. 273330 : agrin 3. 43 418177 N44967 Hs. 351554 Hs. 351554 : Homo sapiens cD FLJ32092 fis, 3. 42 414888 AL039185 Hs. 77558 Hs. 77558 : thyroid hormone receptor intera 3. 42 452445 AB002438 Hs. 29596 Hs. 29596 : Homo sapiens mR from chromosome 3. 41 414803 X03100 Hs. 914 Hs. 914 : major histocompatibility complex, 3. 41 419201 M22324 Hs. 1239 NM 001150 : Homo sapiens alanyl (membrane) 3. 41 445139 AB037848 Hs. 12365 Hs. 12365 : syptotagmin Xlil 3. 41 435021 AA922192 Hs. 73962 Hs. 73962 : EphA7 3. 41 417259 AW903838 Hs. 81800 Hs. 81800 : chondroitinsuifateproteogtyca 3. 40 439737 Al751438 Hs. 41271 Hs. 41271 : Homo sapiens mR full length ins 3. 39 410636 AA088177 Hs. 172870 Hs. 172870 : KIAA1913 protein 3. 39 431590 AB037789 Hs. 263395 Hs. 263395 : sema domain, transmembrane dom 3. 38 415000 AW025529 Hs. 239812 Hs. 239812serologically defined breast c 3. 36 416700 AW498958 Hs. 343475 NM001909 : Homo sapiens cathepsin D (lyso 3. 36 440516 S42303 Hs. 161 NM 001792 : Homosapienscadherin2, type 3. 35 423720 AL044191 Hs. 23388 Hs. 23388 : hypothetical protein DKFZp434F0 3. 32 421902 BE392717 BE392717 : 601307571F1 NlH_MGC_44Homosap 3. 32 409220 BE243323 Hs. 51233 Hs. 51233 : tumor necrosis factor receptor 3. 32 421502 AF111856 Hs. 105039 NM006424 : Homosapienssolutecarrierfa 3. 32 416729 U46165 Hs. 1027 NM004165 : Homo sapiens Ras-related assoc 3. 30 430302 AL137502 Hs. 238679 Hs. 238679 : Rag D protein 3. 30 445084 H38914 Hs. 250848 Hs. 250848 : Homo sapiens cDFU14761fs. 3. 29 406825 A1982529 Hs. 84298 Hs. 84298 : CD74 antigen (invariant polypep 3. 29 446272 BE268912 Hs. 14601 NM005335 : Homo sapiens hematopoietic cel 3. 28 437145 AF007216 Hs. 5462 NM 003759 : Homo sapiens solute carrier fa 3. 27 444071 Ai627808 Hs. 110524 Hs. 110524 : ESTs 3. 27 414662 AL036058 Hs. 76807 Hs. 76807 : majorhistocompatibiiitycompie 3. 27 436576 Api458213 Hs. 77542 Hs. 77542 : ESTs, Weakly similar to S26650 3. 26 424675 NM_005512 Hs. 151641 NM_005512 : Homo sapiens glycoprotein A re 3. 25 437897 AA770561 Hs. 146170 Hs. 146170 : hypothetical protein FLJ22969 3. 25 449703 H61001 Hs. 171802 Hs. 171802 : Homo sapiens, clone IMAGE : 3956 3. 25 414788 X78342 Hs. 77313 Nom003674 : Homo sapiens cyclin-dependent 3. 25 414249 A1797994 Hs. 279929 Hs. 279929 : gp25L2 protein 3. 24

430396 D49742 Hs. 241363 NM 004132 : Homo sapiens hyaluron binding 3. 23 424456 AA341017 Hs. 25549 Hs. 25549 : hypothetical protein FU20898 3. 23 452303 R27257 Hs. 57734 Hs. 57734 : G protein-coupled receptor kise 3. 22 425390 A1092634 Hs. 156114 NM_004648 : Homo sapiens protein tyrosine 3. 21 416033 NM012201 Hs. 78979 NM 012201 : Homo sapiens golgi apparatus p 3. 19 450931 N25156 Hs. 25648 Hs. 25648 : tumor necrosis factor receptor 3. 19 428065 Al634046 Hs. 157313 Hs. 157313 : ESTs 3. 18 422616 BE300330 Hs. 118725 NM012248 : Homo sapiens selenophosphate s 3. 18 439318 AW837046 Hs. 6527 Hs. 6527 : G protein-coupled receptor 56 3. 17 427640 AF058293 Hs. 180015 Nom301355 : Homo sapiens D-dopachrome taut 3. 17 409936 AK001691 Hs. 57655 Hs. 57655 : dudulin 2 3. 16 436001 AW903849 Hs. 173840 Hs. 173840 : similartoendothelialcell-se 3. 16 451154 AA015879 Hs. 33536 Hs. 33536 : ESTs 3. 16 420256 U84722 Hs. 76206 NM001795 : Homo sapiens cadherin 5, type 3. 16 407584 W25945 Hs. 8173 Hs. 8173 : hypothelical protein FU10803 3. 15 428593 AW207440 Hs. 185973 NM 003676 : Homo sapiens degenerative sper 3. 15 410026 A ! 912061 Hs. 55016 Hs. 55016 : EPS8-related protein 2 3. 15 445333 BE537641 Hs. 44278 Hs. 44278 : RA817, member RAS oncogene fami 3. 14 448143 AF039704 Hs. 20478 NM_000391 : Homo sapiens ceroid-lipofuscin 3. 14 423007 AA320134 Hs. 196029 Hs. 196029 : Homo sapiens mR for KIAA1657 p 3. 14 416511 NM_006762 Hs. 79356 Nom006762 : Homo sapiens Lysosomal-associa 3. 14 439237 AW408158 Hs. 318893 Hs. 318893 : ESTs, WeaklysimilartoZ195_H 3. 13 446899 NM005397 Hs. 16426 NM_005397 : Homo sapiens podocalyxin-like 3. 13 413916 N49813 Hs. 75615 NM000483 : HomosapiensapolipoproteinC-3. 13 434398 AA121098 Hs. 3838 NM006622 : Homo sapiens serum-inducible k 3. 12 441283 AA927670 Hs. 131704 Hs. 131704 : ESTs 3. 12 418945 BE246762 Hs. 89499 NM_000698 : Homo sapiens arachidote 5-lipo 3. 12 418458 AA332941 Hs. 85226 NM 000235 : Homo sapiens lipase A lysosom 3. 12 408989 AW361666 Hs. 49500 Hs. 49500 : KIAA0746 protein 3. 11 436906 H95990 Hs. 181244 Hs. 181244 : major histocompatibility compl 3. 11 411089 AA456454 Hs. 355702 Hs. 355702 : ESTs, Weakly similar to AC0048 3. 11 432990 AL036071 Hs. 279899 NM 003820 : Homo sapiens tumor necrosis fa 3. 11 425009 X58288 Hs. 154151 Nom002845 : Homo sapiens protein tyrosine 3. 10 443601 A1078554 Hs. 42658 Hs. 42658 : Homo sapiens cD FLJ30167 fis, c 3. 10 430603 AA148164 Hs. 247280 Hs. 247280 : chromosome 20 open reading fra 3. 10 413672 BE156536 Hs. 353632 Hs. 353632 : ESTs, Moderately similar to hy 3. 09 407786 AA687538 Hs. 38972 NM 005727 : Homo sapiens tetraspan i (TSPA 3. 09 414586 AA306160 Hs. 16488 NM002298 : Homo sapiens lymphocyte cytoso 3. 08 423712 W46802 Hs. 81988 Hs. 81988 : disabled homolog Z mitogen-res 3. 08 438552 AJ245820 Hs. 6314 NM_012410 : Homo sapiens type ttransmembr 3. 06 448364 T08958 Hs. 297214 Hs. 297214 : HSPC141 protein 3. 06 426437 BE076537 Hs. 169895 NM 004223 : Homo sapiens ubiquitin-conjuga 3. 06 437679 NM 014214 Hs. 5753 NM 014214 : Homosapiensinositol (myo)-1 (o 3. 06 422262 AL022315 Hs. 113987 NM006498 : Homosapiens) ectin. ga) actosi 3. 06 410480 R97457 Hs. 63984 NM_001257 : Homosapienscadhenn 13, Hca 3. 05 435818 AA700553 Hs. 368614 Hs. 368614 : ESTs 3. 05 418883 BE387036 Hs. 1211 NM 001611 : Homo sapiens acid phosphatase 3. 05 453613 F06838 Hs. 374476 Hs. 374476 : ESTs 3. 05 408051 A1623351 Hs. 172148 Hs. 172148 : ESTs 3. 05 432278 AL137506 Hs. 274256 Hs. 274256 : hypothetical protein FU23563 3. 04 407949 W21874 Hs. 247057 Hs. 247057 : ESTs, Weakly similar to 210926 3. 04 418090 U57059 Hs. 83429 NM003810 : Homo sapiens tumor necrosis fa 3. 04 433165 AA578904 Hs. 292437 Hs. 292437 : ESTs 3. 03 425809 AA370362 Hs. 57958 Hs. 57958 : EGF-TM7-latrophilin-related pro 3. 03 443884 N20617 Hs. 194397 Hs. 194397 : ESTs, Moderately similar to 22 3. 03 447831 A1433293 Hs. 164115 Hs. 164115 : ESTs 3. 02 413278 BE563085 Hs. 833 NM_005101 : Homosapiensinterferon-sUmul 3. 01 418870 AF147204 Hs. 89414 Hs. 89414 : chemokine (C-X-C motif), recept 3. 00 456376 AA663904 Hs. 89862 Hs. 89862 : TNFRSF1A-associated via death d 3. 00 439738 BE246502 Hs. 9598 Hs. 9598 : sema domain, immunoglobulin doma 3. 00 444416 AW288085 Hs. 11156 NM 016494 : Homo sapiens hypothetical prot 3. 00 406656 M16714 Hs. 89643 Hs. 89643 : transketolase (Wernicke-Korsako 3. 00 406826 AW516005 Hs. 84298 Hs. 84298 : CD74 antigen (invariant polypep 2. 99 418707 U97502 Hs. 87497 Hs. 87497 : butyrophilin, subfamily 3, memb 2. 99 421742 AW970004 Hs. 107528 NM 016108 : Homo sapiens androgen induced 2. 99 406824 AW515961 Hs. 84298 Hs. 84298 : CD74 antigen (invariant polypep 2. 99 435605 AF151815 Hs. 4973 Nom 015680 : Homo sapiens hypothetical prot 2. 98 410491 AA465131 Hs. 64001 Hs. 64001 : Homo sapiens clone 25218 mR seq 2. 98 427648 Api376722 Hs. 180062 NM_004159 : Homo sapiens proteasome (proso 2. 98 411125 AA151647 Hs. 68877 NM 000101 : Homosapienscytochromeb-245 298 435550 A1224456 Hs. 324507 Hs. 324507 : hypotheUca protein FW20986 2. 98 429373 NMJ) 14694 Hs. 200594 NM 014694 : Homo sapiens KIAA0605 gene pro 2. 98 445701 AF055581 Hs. 13131 NM 005475 : Homo sapiens lymphocyte adapto 2. 97 414649 At672727 Hs. 76753 NM000118 : Homosapiensendoglin (Osler-R 2. 97 444207 A1565004 Hs. 374415 Hs. 374415 : ESTs 2. 97 423225 AA852604 Hs. 125359 NM_006288 : Homo sapiens Thy-1 cell surfac 2. 97 407792 A1077715 Hs. 39384 NM_014344 : Homo sapiens four jointed box 2. 97 445707 A1248720 Hs. 114390 Hs. 114390 : ESTs 2. 96 452888 AW955454 Hs. 30942 NM004093 : Homo sapiens ephrin-B2 (EFNB2) 2. 96 418478 U38945 Hs. 1174 Hs. 1174 : cyclin-dependentkiseinhibitor 2. 95 411441 AL042355 Hs. 70202 Hs. 70202 : WOrepeatdomain 10 2. 95 443426 AF098158 Hs. 9329 Hs. 9329 : chromosome 20 open reading frame 2. 94 450876 AF189062 Hs. 285976 Hs. 285976 : LAG1 longevity assurance homol 2. 94

426359 AA376409 Hs. 10862 Hs. 10862 : Homo sapiens cD : FU23313 fis, 2. 94 425421 L11669 Hs. 157145 NM001120 : Homo sapiens tetracycline tran 2. 93 449879 H03573 Hs. 287830 Hs. 287830 : Homo sapiens mR ; cD DKFZp434E1 2. 93 454075 R43826 Hs. 16313 Hs. 16313 : Kruppel-like zinc finger protei 2. 93 421595 AB014520 Hs. 301685 Hs. 301685 : KIAA0620 protein 2. 93 457949 W69171 Hs. 334814 Hs. 334814 : hypothetical protein FLJ14868 2. 92 443987 AW163123 Hs. 10071 NM016551 : Homo sapiens seven transmembra 2. 92 430259 BE550182 Hs. 375142 Hs. 375142 : RaIGEF-like protein 3, mouse h 2. 92 415906 Al751357 Hs. 288741 Hs. 288741 : Homo sapiens cD : FU22256 fis, 2. 91 429762 Api346255 Hs. 216354 NM_006913 : Homo sapiens ring finger prote 2. 91 451527 AF022813 Hs. 26518 NM_003271 : Homo sapiens transmembrane 4s 2. 91 425356 BE244879 Hs. 155939 NM_005541 : Homo sapiens inositol polyphos 2. 91 427080 AW068287 Hs. 301175 NM_002872 : Homo sapiens ras-related C3 bo 2. 91 426432 AF001601 Hs. 169857 NM000305 : Homo sapiens paraoxose 2 (PON2 2. 90 431476 BE612705 Hs. 256697 Hs. 256697 : histidine triad nucleotide bin 2. 89 406659 AA663985 Hs. 277477 Hs. 277477 : majorhistocompatibiiitycomp) 2. 89 451144 AW956103 Hs. 61712 Hs. 61712. Homo sapiens cD FLJ31548 fis, c 2. 89 456362 AW973003 Hs. 179909 Hs. 179909 : nucleanzceptorcoæUvator6 2. 88 426440 BE382756 Hs. 169902 NM_006516 : Homosapienssolutecamerfa 2. 88 456974 M12529 Hs. 169401 NM_000041 : Homo sapiens apolipoprotein E 2. 88 418174 L20688 Hs. 83656 Hs. 83656 : Rho GDP dissociaton inhibitor 2. 88 446055 Al815981 Hs. 12909 Hs. 12909 : mucolipin 1 2. 88 423184 NM 004428 Hs. 1624 NM004428 : Homosapiensephrin-A1 (EF1), 2. 87 427700 AA262294 Hs. 180383 NM_001946 : Homo sapiens dual specificity 2. 87 410668 BE379794 Hs. 159651 NM016629 : Homo sapiens hypothetical prot 2. 87 444143 AW747996 Hs. 160999 Hs. 160999 : ESTs, Weakly similar to 178885 2. 87 407151 H25836 Hs. 301527 Hs. 301527 : ESTs, Moderately similar to un 2. 86 449349 A1825386 Hs. 352579 Hs. 352579 : Homo sapiens, chromosome 20 op 2 86 436997 AA741151 Hs. 137323 Hs. 137323 : ESTs 2. 86 446143 BE245342 Hs. 306079 NM 013336 : Homo sapiens protein transport 2. 86 417355 D13168 Hs. 82002 Hs. 82002 : endothelin receptor type B 2. 86 431685 AW296135 Hs. 267659 NM_006113 : Homo sapiens vav 3 oncogene (V 2. 86 408877 AA479033 Hs. 130315 Hs. 130315 : ESTs 2. 85 429615 AF258627 Hs. 211562 NM005502 : HomosapiensATP-bindingcase 2. 85 412014 A1620650 Hs. 43761 Hs. 43761 : gap junction protein, alpha 7, 2. 84 436749 AA584890 Hs. 5302 NM006149 : Homo sapiens lectn, galactosi 2. 84 419625 U91616 Hs. 182885 NM 004556 : Homo sapiens nuclear factor of 2. 84 439941 A1392640 Hs. 18272 Hs. 18272 : solute carrier family 38, membe Z84 436496 AA281959 Hs. 5210 NM_004877 : Homo sapiens glia maturation f 2. 84 422100 A1096988 Hs. 1115S4 NM_005737 : Homo sapiens ADP-ribosylation 2. 83 439730 AF035292 Hs. 6654 Hs. 6654 : KIAA0657 protein 2. 83 447217 BE465754 Hs. 17778 NM_00387ZHomosapiensneunopilin2 (NRP 2. 83 428343 AL043021 Hs. 12705 Hs. 12705 : similarto HYPOTHETICAL 43. 1 KD 2. 82 440524 R71264 Hs. 16798 Hs. 16798 : Homo sapiens mR ; c0 DKFZp564024 2. 82 415523 AL042003 Hs. 296847 NM_003119 : Homo sapiens spastic parapiegi 2. 81 439668 A1091277 Hs. 302634 Hs. 302634 : (rizzled homolog 8 (Drosophila 2. 81 414570 Y00285 Hs. 76473 NM000876 : Homo sapiens insulin-like grow 2. 80 426535 AU077012 Hs. 288582 NM_006287 : Homo sapiens tissue factor pat 2. 80 409649 AA159216 Hs. 55505 Hs. 55505 : hypothetica) protein FLJ20442 2. 80 406655 M21533 Hs. 277477 Hs. 277477 : major histocompa6bility compl 2. 79 415323 BE269352 Hs949 NM 000433 : Homo sapiens neutrophil cytoso 2. 79 443195 BE148235 Hs. 193063 Hs. 193063 : Homo sapiens cD FU14201 fis, 2. 78 451356 AA748418 Hs. 164577 Hs. 164577 : ESTs 2. 78 450708 AA376654 Hs. 350065 Hs. 350065 : Homo sapiens cD FU30634 fis, 2. 78 433681 A1004377 Hs. 200360 Hs. 200360 : Homo sapiens cD FU13027 fis, 2. 77 442599 AF078037 Hs. 324051 NM_006663 : Homo sapiens ReIA-associated i 2. 76 414509 AW161311 Hs. 76294 NM001780 : Homo sapiens CD63 antigen (mel 2. 76 431394 AK000692 Hs. 252351 Hs. 252351 : HERV-H LTR-associating 2 2. 76 417331 AW411297 Hs. 81972 Hs. 81972 : SHC (Src homology 2 domain cont 2. 76 415995 NM004573 Hs. 355888 NM004573 : Homo sapiens phospholipase C, 2. 75 414911 NM 000107 Hs. 77602 NM 000107 : Homo sapiens damage-specific D 2. 75 425976 C75094 Hs. 334514 Hs. 334514 : chromosome 6 open reading fram 2. 75 407893 BE408359 Hs. 43621 Hs. 43621 : hypothetical protein MBC3205 2. 75 407903 A1287341 Hs. 154029 Hs. 154029 : bHLH factor Hes4 2. 75 416062 AA724811 Hs. 334791 Hs. 334791 : similar to neurol tetraspanin 2. 75 428494 AA233439 Hs. 184634 Hs. 184634 : hypothetical protein FLJ20005 2. 75 421506 BE302796 Hs. 105097 NM003258 : Homosapiensthymidinekise l, 2. 74 427581 NM014788 Hs. 179703 Mot4788 : Homo sapiens tripartite motif-2. 74 424527 AW138558 Hs. 334873 Hs. 334873 : carboxypeptidase M 2. 74 439578 AW263124 Hs. 350547 Hs. 350547 : nuclearnzceptorco-repressor/2. 74 425188 AK002052 Hs. 155071 Hs. 155071 : chromosome 20 open reading fra 2. 74 428013 AF151020 Hs. 181444 NM016456 : Homo sapiens hypothetical prot 2. 73 439333 AW384710 Hs. 132986 Hs. 132986 : Homo sapiens cD FLJ31588 fis, 2. 73 450935 BE514743 Hs. 355753 Nom005851 : Homo sapiens tumor suppressor 2. 73 421532 AW138207 Hs. 146170 Hs. 146170 : hypothetical protein FU22969 2. 73 440502 A1824113 Hs. 78281 Hs. 78281 : regulator of G-protein siglling 2. 73 444981 AW855398 Hs. 12210 Hs. 12210 : tumor endothelial marker 6 2. 72 439219 N33883 Hs. 41322 Hs. 41322 : ESTs 2. 72 416847 L43821 Hs. 80261 NM_006403 : Homo sapiens enhancer of filam 2. 72 433179 AW362945 Hs. 162459 Hs. 162459 : ESTs 2. 72 424528 AW073971 Hs. 238954 Hs. 238954 : ESTs, Weakly similar to putati 2. 71 411213 AA676939 Hs. 69285 NM_003873 : Homo sapiens neuropilin 1 (NRP 2. 70 433012 NM_004045 Hs. 279910 NM_004045HomosapiensATX1 anUoxidant 2. 70

425345 AU077297 Hs. 155894 NM_002827 : Homo sapiens protein tyrosine 2. 69 428923 BE047698 Hs. 188785 Hs. 188785 : ESTs 2. 69 427923 AW274357 Hs. 301406 Hs. 301406 : hypothetical protein PP3501 2. 69 446644 NM 003272 Hs. 15791 NM 003272 : Homo sapiens transmembrane 7 s 2. 69 421743 T35958 Hs. 107614 Hs. 107614 : DKFZP56411171 protein 2. 68 416207 NM 014745 Hs. 79077 NM 014745 : Homo sapiens KIAA0233 gene pro 2. 68 420372 AW960049 Hs. 293660 Hs. 293660 : gene overexpressed in astrocyt 2. 68 420542 Nom-000505 Hs. 1321 Nom000505 : Homo sapiens coagulation facto 2. 67 425069 AA687465 Hs. 298184 Hs. 298184 : potassium voltage-gated channe 2. 67 418558 AW082266 Hs. 86131 NM 003824 : Homo sapiens Fas (TNFRSF6)-ass 2. 67 426251 M24283 Hs. 168383 NM000201 : Homo sapiens intercellular adh 2. 66 406701 AA780613 Hs. 62954 Hs. 62954 : festin. heavy polypeptide 1 2. 66 431681 AK000378 Hs. 267566 Hs. 267566 : hypotheUca protein FU20371 2. 66 412833 AW960547 Hs. 298262 Hs. 298262 : ribosome protein S19 2. 66 433101 AW572317 Hs. 12082 Hs. 12082 : TIGA1 2. 66 414774 X02419 Hs. 77274 NM 002658 : Homo sapiens plasminogen activ 2. 66 427868 Api360119 Hs. 181013 NM_002629 : Homo sapiens phosphoglycerate 2. 66 413929 BE501689 Hs. 75617 Hs. 75617 : collagen, typelV, alpha 2 2. 66 424762 AL119442 Hs. 183684 Hs. 183684 : eukafyofic translation inifiat 2. 66 422048 NM012445 Hs. 288126 NM 012445 : Homo sapiens spondin 2, extrac 2. 65 431350 A1192528 Hs. 164537 Hs. 164537 : ESTs 2. 65 450184 W31096 Hs. 237617 Hs. 237617 : dipeptidylpepGdase 9 2. 65 419285 D31887 Hs. 89868 Hs. 89868 : KIAA0062 protein 2. 65 414217 Al309298 Hs. 279898 Hs. 279898 : HomosapienscD : FU23165fis, 2. 64 451253 H48299 Hs. 26126 NM 006984 : Homo sapiens claudin 10 (CLDN1 2. 64 435905 AW997484 Hs. 5003 Hs. 5003 : SLIT-ROBO Rho GTPase-activating 2. 64 432581 AU076465 Hs. 278441 Nom014634 : Homo sapiens KIAA0015 gene pro 2. 63 415782 AA169345 Hs. 123177 Hs. 123177 : hypothetical protein BC011406 2. 63 430223 NM 002514 Hs. 235935 NM 002514 : Homo sapiens nephroblastoma ov 2. 63 417526 AA568906 Hs. 82240 NM 004177 : Homo sapiens syntaxin 3A (STX3 2. 63 409956 AW103364 Hs. 727 NM 002192 : Homo sapiens inhibin. beta A (2. 63 449843 R85337 Hs. 24030 NM001860 : Homo sapiens solute carrier fa 2. 62 417389 BE260964 Hs. 82045 NM_002391 : Homo sapiens midkine (neurite 2. 62 446312 BE087853 Hs. 171802 Hs. 171802 : Homo sapiens, clone IMAGE : 3956 2. 62 435099 AC004770 Hs. 4756 Hs. 4756 : flap structure-specific endonuci 2. 62 417920 S47833 Hs. 82927 NM 004037 : Homo sapiens adenosine monopho 2. 62 435702 A1033647 Hs. 121001 Hs. 121001 : Homo sapiens, clone MGC : 45521 2. 62 422959 AV647015 Hs. 349256 Hs. 349256 : paired immunoglobulin-like rec 2. 62 419938 AU076772 Hs. 1279 NM001733 : Homo sapiens complement compon 2. 62 450954 Api904740 Hs. 25691 NM005856 : Homo sapiens receptor (calcit 2. 61 421753 BE314828 Hs. 107911 Hs. 107911 : ATP-binding cassette, sub-fami 2. 61 443577 A1078033 Hs. 177170 Hs. 177170 : ESTs, WeaklysimilartoALUB_H 2. 61 453886 R66282 Hs. 20247 Hs. 20247 : ESTs 2. 61 421883 X55079 Hs. 1437 NM000152 : Homo sapiens giueosidase. atph 2. 60 440457 BE387593 Hs. 21321 Hs. 21321 : granutecei) differentiation pr 2. 60 410295 AA741357 Hs. 356624 Hs. 356624 : ESTs 2. 59 420679 X57152 Hs. 99853 NM001436 : Homo sapiens fibriilarin (FBL) 2. 59 451558 NM001089 Hs. 26630 NM001089 : Homo sapiens ATP-binding casse 2. 59 444672 Z95636 Hs. 11669 Hs. 11669 : 1aminin, alpha5 2. 59 408669 Ai493591 Hs. 78146 Hs. 78146 : plateleUendothelial cell adhes 2. 59 426194 T50872 Hs. 2001 Hs. 2001 : thromboxane A synthase i (platel 2. 59 421814 L12350 Hs. 108623 NM003247 : Homo sapiens thrombospondin 2 2. 59 456371 S76825 Hs. 89695 Hs. 89695 : insulin receptor 2. 59 429098 AF030249 Hs. 196176 NM_001398 : Homo sapiens enoyl Coenzyme A 2. 59 414443 AU077268 Hs. 76144 Nu002609 : Homo sapiens platelet-derived 2. 59 428484 AF104032 Hs. 184601 NM003486 : Homosapienssolutecarrierfa 2. 59 453309 Api791809 Hs. 32949 NM005218 : Homo sapiens defensin, beta 1 2. 59 412867 AU076861 Hs. 74637 NM003217 : Homo sapiens tesfis enhanced g 2. 58 432827 Z68128 Hs. 3109 Hs. 3109 : Rho GTPase activating protein 4 2. 58 412669 AW880841 Hs. 96908 NM 006034 : Homo sapiens p53induced prote 2. 58 412115 AK001763 Hs. 73239 Hs. 73239 : hypotheúcalproteinFW10901 2. 58 452866 R26969 Hs. 268016 Hs. 268016 : Homo sapiens cD : FW21243hs, 2. 58 435129 A1381659 Hs. 267086 Hs. 267086 : ESTs 2. 57 424482 BE268621 Hs. 149155 NM 003374 : Homosapiensvoltage-dependent 2. 57 410494 M36564 Hs. 64016 NM 000313 : Homo sapiens protein S (alpha) 2. 56 433895 A1287912 Hs. 3628 NM004834 : Homo sapiens mitogen-acfivated 2. 56 442566 R37337 Hs. 12111 Hs. 12111 : ESTs 2. 56 417640 D30857 Hs. 82353 NM006404 : Homo sapiens protein C recepto 2. 56 442622 NM 000435 Hs. 8546 NM 000435 : Homo sapiens Notch homolog 3 (2. 56 430346 AK000331 Hs. 297641 Hs. 297641 : retinoblastoma-associated fact 2. 55 419344 U94905 Hs. 277445 Hs. 277445 : diacylglycerol kise, zeta (104 2. 55 426500 NM 014638 Hs. 170156 NM 014638 : Homo sapiens KIAA0450 gene pro 2. 55 408048 NM007203 Hs. 42322 NM007203 : Homo sapiens A kise (PRKA) anc 2. 55 450700 AW732799 Hs. 25348 NM005860 : Homo sapiens follistatin-like 2. 54 417018 M16038 Hs. 80887 NM 002350 : Homosapiensv-yes-lYamaguchi 2. 54 419378 R24922 Hs. 90078 Hs. 90078 : nucleotide-sugar transporter si 2. 54 422451 AA310753 Hs. 42491 Hs. 42491 : ESTs, Moderately similar to hyp 2. 53 435906 A1686379 Hs. 110796 Hs. 110796 : SARi protein 2. 53 400231 2. 53 417849 AW291587 Hs. 82733 NM_007361 : Homo sapiens nidogen 2 (NID2). 2. 53 427380 NM_005534 Hs. 177559 NM_005534 : Homo sapiens interferon gamma 2. 52 428385 AF112213 Hs. 184062 Hs. 184062 : chromosome 20 open reading fra 2. 52 438000 Api825880 Hs. 5985 Hs. 5985 : non-kise Cdc42 effector protein 2. 52

448719 AA033627 Hs. 21858 Hs. 21858 : serine (orcysteine) proteisei 2. 52 422396 W21872 Hs. 7907 Hs. 7907 : L-fucose kise 2. 52 420787 AA564248 Hs. 351292 Hs. 351292 : Homo sapiens cD FU32605 fis, 2. 51 430590 AW383947 Hs. 246381 NM001251 : Homo sapiens CD68 antigen (CD6 2. 51 447026 BE313144 Hs. 324844 Hs. 324844 : hypothetical protein IMAGE3455 2. 51 439223 AW238299 Hs. 250618 Hs. 250618 : UL16 binding protein 2 2. 50 435151 AA348482 Hs. 4788 Hs. 4788 : nicatrin 2. 50 448202 ABOO2292 Hs. 20695 NM014629 : Homo sapiens Rho guanine nucle 2. 50 449943 AF104266 Hs. 24212 Hs. 24212 : 1atrophilin 2. 50 425743 BE396495 Hs. 159428 Hs. 159428 : BCL2-associated X protein 2. 50 444681 AJ243937 Hs. 288316 Hs. 288316 : chromosome 6 open reading fram 2. 50 421643 BE281170 Hs. 106357 NM007126 : Homo sapiens valosin-containin 2. 50 426865 D63476 Hs. 172813 Nom003899 : Homo sapiens Rho guanine nucle 2. 50 432306 Y18207 Hs. 303090 NM_005398 : Homo sapiens protein phosphata 2. 49 421846 AA017707 Hs. 1432 NM 002743 : Homo sapiens protein kise C su 2. 49 421905 A1660247 Hs. 32699 Hs. 32699 : Homo sapiens, Similar to RIKEN 2. 49 419493 AF001212 Hs. 90744 NM_002815 : Homo sapiens proteasome (proso 2. 49 422530 AW972300 Hs. 118110 NM004335 : Homo sapiens bone marrow strom 2. 48 442821 BE391929 Hs. 8752 NM014255 : Homo sapiens transmembrane pro 2. 48 416919 T97839 Hs. 80464 NM006402 : Homo sapiens hepatitis 8 virus 2. 48 . 443105 X96753 Hs. 9004 NM_001897 : Homo sapiens chondroifin sulfa 2. 48 430040 AW503115 Hs. 227823 Nom014287 : Homo sapiens pM5 protein (PM5) 2. 48 428028 U52112 Hs. 182018 NM_00156§Homosapiensinterieukin-1 ec 2. 47 424307 AW293399 Hs. 356377 Hs. 356377 : Homo sapiens, clone MAGE : 3633 2. 46 434511 R28982 Hs. 18106 Hs. 18106 : ESTs, Weakly similar to T06291 2. 46 454390 AB020713 Hs. 56966 Hs. 56966 : KIAA0906 protein 2. 46 417785 X59812 Hs. 82568 NM 000784 : Homo sapiens cytochrome P450, 2. 46 424673 AA345051 Hs. 294092 Hs. 294092 : Homo sapiens mR full length in 2. 46 422003 AA361760 Hs. 296326 Hs. 296326 : ESTs, Weakly similar to A33533 2. 46 432126 AA865239 Hs. 37196 Hs. 37196 : putative G protein coupled rece 2. 46 445937 A1452943 Hs. 321231 NM 003779 : Homo sapiens UDP-Gal : betaGlcc 2. 46 409354 N68188 Hs. 159472 Hs. 159472 : Homo sapiens cD : FU22224 fis. 2. 46 401179 2. 46 418151 AA864238 Hs. 83583 NM005731 : Homo sapiens actin rotated pro 2. 45 422648 D86983 Hs. 118893 Hs. 118893 : Melanoma associated gene 2. 45 427759 BE245578 Hs. 2200 NM 005041 : Homo sapiens perfodn I (prefo 2. 45 431222 X56777 Hs. 273790 NM007155 : Homo sapiens zo pellucida glyc 2. 45 411529 AA430348 Hs. 317596 Hs. 317596 : Homo sapiens cD FU12927 fis, 2. 45 426825 AL133415 Hs. 297753 NM003380 : Homo sapiens vimentin (VIM), m 2. 45 422242 AJ251760 Hs. 273385 Nom016592 : Homo sapiens GS complex locus 2. 45 408105 AW152207 Hs. 270977 Hs. 270977 : ESTs 2. 44 426410 BE298446 Hs. 305890 Hs. 305890 : BCL2-like 1 2. 44 421064 A1245432 Hs. 101382 NM00629t : Homo sapiens tumor necrosis fa 2. 44 428157 Api738719 Hs. 198427 Nom000189 : Homo sapiens hexokise 2 (HK2), 2. 44 424398 BE397787 Hs. 146393 NM_014685 : Homo sapiens homocysteine-indu 2. 44 424825 AF207069 Hs. 153357 NM001084 : Homo sapiens procollagen-lysin 2. 44 426031 AA295251 Hs. 166066 Hs. 166066 : åsplaún resistance associate 2. 43 409817 BE295464 Hs. 56607 Hs. 56607 : Williams-Beuren syndrome chromo 2. 43 429359 W00482 Hs. 2399 NM004995 : Homo sapiens matrix metallopro 2. 43 426761 A1015709 Hs. 172089 Hs. 172089 : pro-oncosisreceptorinducing 2. 43 429332 AF030403 Hs. 199263 NM 013233 : Homo sapiens serine threonine 2. 43 425923 NM005026 Hs. 162808 NM 005026 : Homo sapiens phosphoinositide-2. 43 432211 BE274530 Hs. 273333 Hs. 273333 : hypotheticai protein FU10986 2. 43 433339 AF019226 Hs. 8036 Hs. 8036 : RAB3D, member RAS oncogene famil 2. 42 420539 AA282735 Hs. 44004 Hs. 44004 : AD031 protein 2. 42 413243 AA769266 Hs. 193657 Hs. 193657 : ESTs 2. 42 435029 AF167706 Hs. 19280 Hs. 19280 : cysteine-richmotorneuron 1 2. 42 422374 AW732869 Hs. 1519 Hs. 1519 : protein kise, cAMP-dependent, re 2. 42 444501 AW247624 Hs. 11342 NM004148 : Homosapiensninjunnl (NINJ1 2. 42 414919 AW087337 Hs. 194461 Hs. 194461 : ESTs 2. 42 419355 AA428520 Hs. 90061 NM 006667 : Homo sapiens progesterone rece 2. 42 436042 AF284422 Hs. 119178 Hs. 119178 : cation-ch ! ohdecotransporter- 2. 42 418245 AA088767 Hs. 83883 Hs. 83883 : transmembrane, prostate androge 2. 42 444215 AB033075 Hs. 10669 Hs. 10669 : development and differentiation 2. 41 408683 R58665 Hs. 46847 NM016614 : Homo sapiens TRAF and TNF rece 2. 41 423701 AA329856 Hs. 143022 Hs. 143022 : ESTs 2. 41 441783 BE313412 Hs. 7961 Hs. 7961 : Homo sapiens clone 25012 mR sequ 2. 41 428072 BE258602 Hs. 182366 NM 016292 : Homo sapiens heat shock protei 2. 41 434599 AB002313 Hs. 3989 Hs. 3989 : plexin B2 2. 40 442351 W52642 Hs. 8261 Hs. 8261 : SPRY domain-containing SOCS box 2. 40 407894 AJ278313 Hs. 41143 Hs. 41143 : phospholipase C, beta 1 (phosph 2. 40 453449 W16752 Hs. 32981 Hs. 32981 : sema domain, immunoglobulin dom 2. 40 408688 Api634522 Hs. 152925 Hs. 152925 : KIAA1268 protein 2. 40 422448 AW372922 Hs. 116774 Hs. 116774 : integrin, alpha 1 2. 39 416269 AA177138 Hs. 161671 Hs. 161671 : ESTs 2. 39 452679 Z42387 Hs. 83883 Hs. 83883 : transmembrane. prostate androge 2. 38 432981 NM002733 Hs. 3136 NM002733 : Homo sapiens protein kise, AMP 2. 38 419846 NM_015977 Hs. 285681 Hs. 285681 : Williams Beuren syndrome chrom 2. 38 422110 Al376736 Hs. 111779 Hs. 111779 : secreted protein, acidic, cyst 2. 38 413092 AA126856 Hs. 118665 Hs. 118665 : ESTs 2. 38 433969 AW207279 Hs. 271786 Hs. 271786 : ESTs, Weakly similar to PC4395 Z37 451267 A1033894 Hs. 117865 Hs. 117865 : solutecarierfamily17 (anio 2. 37 447526 AL048753 Hs. 303649 NM002982 : Homo sapiens small inducible c 2. 37

441623 AA315805 Hs. 348710 Hs. 348710 : Homo sapiens, clone MAGE : 4242 2. 37 420255 NM 007289 Hs1298 NM_007289 : HomosaPiensmembranemetailo-237 409274 NM 003930 Hs. 52644 NM 003930 : Homo sapiens src family associ 2. 36 422801 AF125672 Hs. 287994 Hs. 287994 : nuclearreceptorco-repressor 2. 36 407887 AA579668 Hs. 41072 Hs. 41072 : serine (orcysteine) proteisei 2. 36 408212 AA297567 Hs. 43728 NM 015696 : Homo sapiens weakly similar to 2. 36 430478 NM_014349 Hs. 241535 NM_014349 : Homo sapiens apolipoprotein L, Z36 405102 2. 35 423583 AL122055 Hs. 129836 Hs. 129836 : KIAA1028 protein 2. 35 426125 X87241 Hs. 166994 NM005245 : Homo sapiens FAT tumor suppres 2. 35 425204 NM 002436 Hs. 1861 NM002436 : Homo sapiens membrane protein, 2. 35 420676 A1434780 Hs. 4248 Hs. 4248 : Homo sapiens PP3781 mR, complete 2. 35 421079 AW404994 Hs. 101695 Hs. 101695 : NCK adaptor protein 2 2. 35 410039 AF207989 Hs. 58014 Hs. 58014 : G protein-coupled receptor, fam 2. 34 412958 BE391579 Hs. 75087 NM 006712Homo sapiens FAST kise (FASTK) Z34 430363 M28713 Hs. 274464 NM_000398 : Homo sapiens diaphorase (DH) (2. 34 425397 J04088 Hs. 156346 NM_001067 : Homo sapiens topoisomerase (D) 2. 34 451035 AU076785 Hs. 430 NM002670 : Homo sapiens plastin 1 (I isof 2. 34 449027 AJ271216 Hs. 22880 Hs. 22880 : dipepUdylpepbdase 111 2. 34 429457 BE243065 Hs. 202955 Hs. 202955 : hypotheUcal protein FLJ20507 2. 34 417709 D87434 Hs. 82426 NM014734 : Homo sapiens KIAA0247 gene pro 2. 34 412805 AW954569 Hs. 278675 Hs. 278675 : bromodomain-containing 4 2. 34 427647 W19744 Hs. 180059 Hs. 180059 : Homo sapiens cD FLJ31360 fis, 2. 34 430702 U56979 Hs278568 NM 000186 : Homo sapiens H factor 1 (comp) 2. 33 456804 Al421645 Hs. 139851 NM001233 : Homo sapiens caveolin 2 (CAV2) 2. 33 453648 W21493 Hs. 28329 Hs. 28329 : protein phosphatase 1, regulato 2. 33 450812 AB002360 Hs. 25515 Hs. 25515 : MCF. 2celilinederivedtransfo 2. 33 402575 2. 33 424670 W61215 Hs. 116651 NM 005797 : Homo sapiens epithelial V-like 2. 32 452960 AK001335 Hs. 31137 NM006504 : Homo sapiens protein tyrosine 2. 32 442968 AK000606 Hs. 8868 NM004871 : Homo sapiens golgi SP receptor 2. 32 410639 BE269047 Hs. 65234 Hs. 65234 : DEAD/H (Asp-Glu-Ala-Asp/His) bo 2. 32 415169 W42913 Hs. 78089 NM004231 : HomosapiensATPae, H+transp 2. 32 450160 BE048099 Hs. 183738 Hs. 183738 : FERM, RhoGEF (ARHGEF) and plec 2. 32 407223 H96850 H96850 : ywO3bl2. sl Soares melanocyte 2NbH 2. 32 426780 BE242284 Hs. 172199 NM 001114 : Homo sapiens adenylate cyclase 2. 32 434987 AW975114 Hs. 371677 Hs. 371677 : ESTs 2. 32 416354 NM000633 Hs. 79241 NM_000633 : HomosapiensB-cellCLLtiympho Z31 453107 NM 016113 Hs. 279746 NM 016113 : Homo sapiens transient recepto 2. 31 422963 M79141 Hs. 13234 Hs. 13234 : ESTs, Weaklysimilartohypothe 2. 31 433618 AA602539 Hs. 345494 Hs. 345494 : ESTs, Moderately similar to ZN 2. 31 438584 AA811347 AA811347 : ob81hO6. sl NCI_CGAP GCB1 Homos 2. 31 446126 AW085909 Hs. 356618 Hs. 356618 : ESTs, Weakly similar to PC4259 2. 31 408716 A1567839 Hs. 151714 Hs. 151714 : peroxisomal proliferator-activ 2. 30 433230 AW136134 Hs. 220277 Hs. 220277 : ESTs, Weakly similar to expres 2. 30 410168 AW834050 Hs. 351432 Hs. 351432 : tensin 2. 30 446342 BE298665 Hs. 14846 Hs. 14846 : Homo sapiens mR ; cD DKFZp564D01 2. 30 418452 BE379749 Hs. 85201 NM005127 : Homo sapiens G-type (calcium d 2. 30 453175 Nom-006834 Hs. 32217 NM006834 : Homo sapiens RAB32, member RAS 2. 29 409012 AL117435 Hs. 49725 Hs. 49725 : DKFZP4341216 protein 2. 29 452848 A1417193 Hs. 288912 Hs. 288912 : BBP-like protein 2 2. 29 418838 AW385224 Hs. 35198 Hs. 35198 : ectonucleotide pyrophosphatase/2. 29 422562 A1962060 Hs. 118397 NM001129 : HomosapiensAEbindingprotei 2. 28 432828 AB042326 Hs. 287402 Hs. 287402 : chondroiún 4-sulfotransferase 2. 28 412948 BE243313 Hs. 334851 NM 006148 : Homo sapiens LIM and SH3 prote 2. 28 426068 AF029778 Hs. 166154 NM002226 : Homo sapiens jagged 2 (JAG2). 2. 28 456919 Nom 003900 Hs. 182248 NM003900 : Homo sapiens sequestosome 1 (S 2. 28 452806 AW014549 Hs. 58373 Hs. 58373 : ESTs 2. 28 453983 H94997 Hs. 16450 Hs. 16450 : ESTs 2. 28 407736 N41744 Hs. 349326 Hs. 349326 : Homo sapiens cD FLJ3067 fis, 2. 28 413211 AW967107 Hs. 109274 Hs. 109274 : hypothetical protein MGC4365 2. 28 422051 AW327546 Hs. 111024 Hs. 111024 : solutecanierfamily25 (mito 2. 27 438438 AA257992 Hs. 50651 Hs. 50651 : Janus kise 1 (a protein tyrosin 2. 27 436278 BE396290 Hs. 5097 NM_004710 : Homosapienssyptogyrin2 (SYN 2. 27 454080 Al199711 Hs. 576 NM_000147 : Homo sapiens fucosidase, alpha 2. 27 426542 AF190746 Hs. 170310 NM017424 : Homo sapiens cat eye syndrome 2. 27 417115 AW952792 Hs. 334612 NM003094 : Homosapienssmallnuclearrib 2. 27 402901 2. 26 412898 Al129903 Hs. 74669 NM_006634 : Homo sapiens vesicle-associate 2. 26 413020 R98736 R98736 : yr31hO9. rl Soaesfetaliverspl 2. 26 413939 AL047051 Hs. 199961 Hs. 199961 : ESTs, Weakly similar to hypoth 2. 26 408681 AW953853 Hs. 281462 Hs. 281462 : hypothetical protein FLJ14251 2. 25 412330 NM005100 Hs. 788 NM005100 : Homo sapiens A kise (PRKA) anc 2. 25 442083 R50192 Hs. 165062 Hs. 165062 : ESTs 2. 25 418271 NM000919 Hs. 83920 NM000919 : Homo sapiens peptidylglycine a 2. 25 433376 A1249361 Hs. 74122 NM001225 : Homo sapiens caspase 4, apopto 2. 25 438562 A1566826 Hs. 25890 Hs. 25890 : ESTs, Weakly similar to transdu 2. 25 443883 AA114212 Hs. 9930 NM001235 : Homosapiensserine (orcystei 2. 25 416976 BE243985 Hs. 80680 Hs. 80680 : major vault protein 2. 24 416914 AA344481 Hs. 80426 Hs. 80426 : brain and reproductive organ-ex 2. 24 400288 X06256 Hs. 149609 NM_002205 : Homo sapiens integrin, alpha 5 2. 24 407904 W44735 Hs. 107260 Hs. 107260 : putative UDP-Galc : po) ypeptide 2. 24 429690 AW956329 Hs. 23721 Hs. 23721 : ESTs 2. 24

443813 AA876372 Hs. 93961 Hs. 93961 : HomosapiensmRcDDKFZp667D09 2. 24 427458 BE208364 Hs. 29283 Hs. 29283 : ESTs, Weakly similar to LKHU pr 2. 24 454294 AB000734 Hs. 50640 NM003745 : Homo sapiens JAK binding prote 2. 24 407192 AA609200 Hs. 366318 Hs. 366318 : ESTs 2. 23 425751 T19239 Hs. 1940 NM001885 : Homo sapiens crystallin, alpha 2. 23 456437 Al924228 Hs. 115185 Hs. 115185 : ESTs 2. 23 413019 BE281604 Hs. 75140 NM 002337 : Homo sapiens low density lipop 2. 23 418862 BE550964 Hs. 89399 Hs. 89399 : ATPsynthase, H+transporting, 2. 23 435284 AA879470 Hs. 96849 Hs. 96849 : Homo sapiens cD FLJ11492 fis, c 2. 23 429630 M85289 Hs. 211573 NM005529 : Homo sapiens heparan sulfate p 2. 23 427609 AK000436 Hs. 179791 Hs. 179791 : RAB20, member RAS oncogene fam 2. 23 421917 AB028943 Hs. 109445 Hs. 109445 : hypermethylated in cancer 2 2. 23 446616 R65964 Hs. 334873 Hs. 334873 : carboxypeptidase M 2. 23 407232 X04526 X04526 : Human liver mR for beta-subunit s 2. 23 423798 AF047033 Hs. 132904 Hs. 132904 : solute carrier family 4, sodiu Z23 446755 AW451473 Hs. 16134 NM005990 : Homo sapiens serine/theonine 2. 22 452865 Api924046 Hs. 119567 Hs. 119567 : ESTs, Weakly similar to AW i-H 2. 22 431393 AW971493 Hs. 134269 Hs. 134269 : ESTs, Weakly similar to 200439 2. 22 431890 X17033 Hs. 271986 NM002203 : Homo sapiens integrin, alpha 2 2. 22 428782 X12830 Hs. 193400 NM000565 : Homo sapiens inteneukin 6 rec 2. 22 446006 NM 004403 Hs. 13530 NM004403 : Homo sapiens deafness, autosom 2. 22 436418 AJ245874 Hs. 4245 Hs. 4245 : chromosome 11 hypothetical prote 2. 22 423869 BE409301 Hs. 134012 NM006688 : HomosapiensClq-nelatedfæto 2. 21 437730 AW071087 Hs. 239176 Hs. 239176 : insulin-like growth factor 1 r 2. 21 444020 R92962 Hs. 35052 Hs. 35052 : ESTs 2. 21 413882 AA132973 Hs. 184492 Hs. 184492. Homo sapiens mR ; cD DKFZp667B0 2. 21 412654 A1093480 Hs. 374319 Hs. 374319 : ESTs 2. 21 448988 Y09763 Hs. 22785 NM004961 : Homo sapiens gamma-aminobutyh 2. 21 426841 A1052358 Hs. 131741 Hs. 131741 : ESTs 2. 21 408196 AL034548 Hs. 43627 NM006943 : Homo sapiens SRY (sex determin 2. 21 451711 AK000461 Hs. 26890 Hs. 26890 : cat eye syndrome chromosome reg 2. 20 414325 AA251929 Hs. 355341 Hs. 355341 : Homo sapiens, clone IMAGE : 3536 2. 20 424512 X53002 Hs. 149846 NM002213 : Homo sapiens integrin, beta 5 2. 20 448883 BE614989 Hs. 7503 Hs. 7503 : hypothetica) protein FU14153 2. 20 411296 BE207307 Hs. 10114 Hs. 10114 : growth suppressor 1 2. 20 452268 NM 003512 Hs. 28777 NM003512 : Homo sapiens H2A histone famil 2. 20 416810 AF035606 Hs. 80019 NM013232 : Homo sapiens programmed cell d 2. 20 441415 H21497 Hs. 7471 Hs. 7471 : BBP-like pnotein 1 2. 20 444212 AW503976 Hs. 10649 NM004848 : Homo sapiens basement membrane 2. 19 428044 AA093322 Hs. 301404 NM 006743 : Homo sapiens R binding motif p 2. 19 430017 AA263172 Hs. 35 NM002832 : Homo sapiens protein tyrosine 2. 19 424490 AJ278016 Hs. 55565 Hs. 55565 : ankyrin repeat domain 3 2. 19 431193 AW749505 Hs. 296770 Hs. 296770 : KIAA1719 protein 2. 19 453686 AL110326 Hs. 304679 Hs. 304679 : ESTs, WeaklysimilartoZ195_H 2. 19 448262 AW880830 Hs. 186273 Hs. 186273 : ESTs 2. 19 416065 BE267931 Hs. 78996 NM 002592 : Homo sapiens proliferating cel 219 442045 C05768 Hs. 8078 Hs. 8078 : HomosapienscloneFBD3Cn-du-c 2. 19 423804 AW403448 Hs. 1706 NM 006084 : Homo sapiens interferon-stimui 2. 19 428024 Z29067 Hs. 2236 Hs. 2236 : NIMA (never in mitosis gene a)-r 2. 19 424503 NM002205 Hs. 149609 NM002205 : Homo sapiens integrin, alpha 5 2. 19 437696 Z83844 Hs. 5790 Hs. 5790 : hypothetical protein dJ37E16. 5 2. 18 405204 2. 18 426158 NM001982 Hs. 199067 NM001982 : Homo sapiens v-erb-b2 erythrob 2. 18 417418 NM002468 Hs. 82116 NM002468 : Homo sapiens myeloid different 2. 18 412773 H15785 Hs. 74573 NM012268 : Homo sapiens similar to vaccin 2. 18 409402 AF208234 Hs. 695 Nom000100 : Homo sapiens cystatin B (stefi 2. 18 443791 N64458 Hs. 143345 Hs. 143345 : ESTs 2. 18 435049 AL122067 Hs. 4746 Hs. 4746 : hypothetica) protein FU21324 2. 18 418389 AA830613 Hs. 293849 Hs. 293849 : ESTs 2. 18 450712 A1732130 Hs. 270496 Hs. 270496 : ESTs, Weakly similar to ALUB H 2. 18 422007 Api739435 Hs. 39168 Hs. 39168 : ESTs, Weakly similar to T17340 218 453676 AW853745 Hs. 286035 Hs. 286035 : hypothetical protein FLJ22686 2. 18 415718 F30631 Hs. 200237 Hs. 200237 : ESTs 2. 18 452688 AA721140 Hs. 49930 Hs. 49930 : ESTs, Weakly similar to 834087 2. 18 415988 BE407713 Hs. 78943 NM_000386 : Homo sapiens bleomycin hydrola 2. 18 409453 A1885516 Hs. 95612 Hs. 95612 : ESTs 2. 17 417512 X76534 Hs. 82226 NM002510 : Homo sapiens glycoprotein (tra 2. 17 427202 BE272922 Hs. 173936 Nom-000628 : Homo sapiens inteneukin 10 re 2. 17 440983 M20681 Hs. 7594 NM 006931 : Homo sapiens solute carrier fa 2. 17 416084 L16991 Hs. 79006 NM012145 : Homo sapiens deoxythymidylate 2. 17 429642 X68264 Hs. 211579 NM006500 : Homo sapiens melanoma adhesion 2. 17 427213 AW007211 Hs. 348389 Hs. 348389 : hypotheticalprotein FLJ12876 2. 17 437763 AA469369 Hs. 5831 NM_003254 : Homo sapiens tissue inhibitor 2. 17 454000 AA040620 Hs. 5672 Hs. 5672 : golgi membrane protein SB140 2. 17 424247 X14008 Hs. 234734 NM_000239 : Homo sapiens lysozyme (rel amy 2. 16 403857 2. 16 406648 AA563730 Hs. 277477 Hs. 277477 : major histocompa6bility compl 2. 16 400265 2. 16 442379 NM 004613 Hs. 8265 NM004613 : Homo sapiens transglutamise 2 2. 16 441892 AB028981 Hs. 8021 Hs. 8021 : KIAA1058 protein 2. 16 417446 AL118671 Hs. 82163 NM 000898 : Homo sapiens monoamine oxidase 2. 16 418386 AA361739 Hs. 84549 NM_002494 : Homo sapiens DH dehydrogese (u 2. 16 414053 BE391635 Hs. 75725 NM_003564 : Homo sapiens transgelin 2 (TAG 2. 16

440906 AW161556 Hs. 240170 Hs. 240170 : hypothetical protein MGC2731 2. 16 447660 AW160386 Hs. 163667 Hs. 163667 : ESTs, Weakly similar to CAlH_H 2. 16 408279 AF216965 Hs. 44095 Hs. 44095 : cyclin M3 2. 16 426152 BE299190 Hs. 167246 Hs. 167246 : P450 (cytochrome) oxidoreducta 2. 16 437952 D63209 Hs. 5944 NM_014585 : Homo sapiens solute carrier fa 2. 16 415661 AF057307 Hs. 78575 Hs. 78575 : prosaposin (variantGaucher dis 2. 15 425302 U79115 Hs. 155566 NM003805 : Homo sapiens CASP2 and RIPK1 d 2. 15 425996 W67330 Hs. 374451 Hs. 374451 : ESTs 2. 15 413745 AW247252 Hs. 75514 NM 000270 : Homo sapiens nucleoside phosph 2. 15 422070 AF149785 Hs. 111126 Hs. 111126 : pituitary tumor-transforming 1 2. 15 448424 AW009892 Hs. 31924 Hs. 31924 : ESTs 2. 15 430035 NM_003463 Hs. 227777 NM003463 : Homo sapiens protein tyrosine 2. 15 438407 Api457122 Hs. 129673 Hs. 129673 : eukaryotic translation initial 2. 15 435551 AF212365 Hs. 5470 Hs. 5470 : interieukin 17B receptor 2. 15 437741 BE561610 Hs. 5809 Hs. 5809 : putatve transmembrane protein ; 2. 15 441192 AA526626 Hs. 7736 NM016504 : Homo sapiens mitochonddal db 2. 15 435750 AB029012 Hs. 4990 Hs. 4990 : KIAA1089 protein 2. 15 411165 NM 000169 Hs. 69089 NM000169 : Homosapiensgaæiosidase, a 2. 14 425252 AW391162 Hs. 349306 Hs. 349306 : hypotheticai protein FU31951 2. 14 427600 AW630918 Hs. 179774 NM002818 : Homo sapiens proteasome (proso 2. 14 426818 AA554827 Hs. 292996 Hs. 292996 : postmeiotic segregation incrsa 2. 14 442110 AF113008 Hs. 8102 Nom001023 : Homosapiensribosomaprotein 2. 14 407797 AK000524 Hs. 39850 Hs. 39850 : uridinekise-likel 443044 N28522 Hs. 8935 NM_014298 : Homo sapiens quinolite phospho 2. 14 437103 AW139408 Hs. 152940 Hs. 152940 : ESTs 2. 14 442069 AW664144 Hs. 297007 Hs. 297007 : Homo sapiens cD FU32174 fis, 2. 14 424954 NM 000546 Hs. 1846 NM000546 : Homo sapiens tumor protein p53 2. 14 458097 AW341135 Hs. 58104 Hs. 58104 : Homo sapiens, clone IMAGE : 47309 2. 14 411925 AW014588 Hs. 72925 NM 003475 : Homo sapiens chromosome 11 ope 2. 14 449644 AW960707 Hs. 148324 Hs. 148324 : ESTs 2. 14 422675 BE018517 Hs. 119140 NM 001970 : Homosapienseukayoticbransl 2. 14 428586 M36712 Hs. 2299 Hs. 2299 : CD8 antigen, beta potypeptidel 2. 14 429379 NM014840 Hs. 200598 NM014840 : Homo sapiens KIAA0537 gene pro 2. 13 410290 AA402307 Hs. 322844 Hs. 322844 : hypothetical protein OKFZp564A 2. 13 443895 AW979048 Hs. 292566 Hs. 292566 : YEA4 protein 2. 13 428145 BE243327 Hs. 182626 NM012264 : Homo sapiens chromosome 22 ope 2. 13 453518 AW503205 Hs. 27268 Hs. 27268 : HomosapienscD : FU21933fis, 2. 13 456534 X91195 Hs. 100623 Hs. 100623 : protein phosphatase 1, reXqulat 2. 13 419972 AL041465 Hs. 182982 Hs. 182982golgin-67 2. 13 424950 AA602917 Hs. 156974 Hs. 156974 : ESTs 2. 13 427557 NMJM2659 Hs. 179657 NM_002659 : Homo sapiens plasminogen acftv 2. 13 431449 M55994 Hs. 256278 NM001066 : Homo sapiens tumor necrosis fa 2. 13 418758 AW959311 Hs. 172012 Hs. 172012 : hypothetical protein DKFZp434J 2. 13 434202 BE382411 Hs. 3764 NM 000858 : Homo sapiens guanylate kise 1 2. 13 433233 AB040927 Hs. 301804 Hs. 301804 : KIAA1494 protein 2. 12 452700 A1859390 Hs. 288940 Hs. 288940 : transmembrane protein 8 (five 2. 12 438033 T26483 Hs. 6059 NM_016938 : Homo sapiens EGF-containing fi 2. 12 400847 2. 12 447547 NM 007229 Hs. 18842 NM007229 : Homo sapiens protein kise C an 2. 12 417052 NM 000712 Hs. 81029 NM_000712 : Homo sapiens biliverdin reduct 2. 12 413284 AU077055 Hs. 289107 Nom001166 : Homo sapiens baculoviral IAP r 2. 11 434558 AW264102 Hs. 39168 Hs. 39168 : ESTs, Weakly similar to T17340 2. 11 404030 2. 11 410801 BE275469 Hs. 66493 Hs. 66493 : Down syndrome critical region g 2. 11 418613 AA744529 Hs. 86575 Hs. 86575 : mitogen-æUvated protein kise 2. 11 447087 AW403870 Hs. 301872 Hs. 301872 : hypothetical protein MGC4840 2. 11 433026 AW160616 Hs. 279921 Nom016127 : Homo sapiens hypothetical prot 2. 11 426433 L38969 Hs. 169875 NM007112 : Homo sapiens thrombospondin 3 2. 11 442439 U09759 Hs. 246857 NM002752 : Homo sapiens mitogen-acbvated 2. 11 437379 AL359575 Hs. 23765 Hs. 23765 : membrane metalio-endopeptidase-2. 11 400208 2. 11 455705 AW161061 Hs. 356580 Hs. 356580 : ESTs, Weakly similar to zinc t 2. 11 417599 AA204688 Hs. 62954 Hs. 62954 : femfin, heavy polypeptide 1 2. 10 416728 AB024597 Hs. 79658 NM001894 : Homo sapiens casein kise 1, ep 2. 10 439920 H05430 Hs. 288433 Hs. 288433 : neurotrimin 2. 10 422309 U79745 Hs. 114924 NM004694 : Homo sapiens solute carrier fa 2. 10 436114 AA778232 Hs. 19515 Hs. 19515 : ESTs, HighlysimilartoNRG3_HU 2. 10 405517 2. 10 421872 AA359753 Hs. 22824 Hs. 22824 : MYB binding protein (P160) la 2. 10 437712 X04588 Hs. 85844 Hs. 85844 : neurotrophic tyrosine kise, rec 2. 10 431214 AA294921 Hs. 348024 NM002881 : Homo sapiens v-ral simian leuk 2. 10 412856 BE386745 Hs. 74631 NM 001728 : Homo sapiens basigin (BSG), mR 2. 10 442064 A1422867 Hs. 88594 Hs. 88594 : Homo sapiens, clone IMAGE : 43329 2. 10 434845 BE267057 Hs. 325321 Hs. 325321 : WD repeat domain 18 2. 10 426728 NM 007118 Hs. 367689 NM007118 : Homosapienstriplefunctold 2. 10 419596 BE379320 Hs. 91448 NM007026 : Homo sapiens dual specificity 2. 09 448913 AA194422 Hs. 22564 NM004999 : Homo sapiens myosin VI (MY06), 2. 09 414721 X90392 Hs. 77091 NM-006730 : Homosapiensdeoxyribonuclease 2. 09 424658 NM 002406 Hs. 151513 NM002406 : Homo sapiens mannosyl (alpha-1 2. 09 432805 X94630 Hs. 3107 Hs. 3107 : CD97 antigen 2. 09 447032 AK000310 Hs. 17138 Hs. 17138 : hypotheticai protein FU20303 2. 09 447484 AA464839 Hs. 292566 Hs. 292566 : YEA4 protein 2. 09 440188 AK001812 Hs. 7036 Hs. 7036 : N-acetylglucosamine kise 2. 09

445584 AF217518 Hs. 8360 Hs. 8360 : PTD012 protein 2. 09 402559 2. 09 418043 AW377752 Hs. 83341 Hs. 83341 : AXL receptor tyrosine kise 2. 09 448888 AW196663 Hs. 200242 Hs. 200242 : caspase recruitment domain fam 2. 09 436910 AA926944 Hs. 261587 Hs. 261587 : GCN2elF2alphakise 2. 09 422573 AW297985 Hs. 295726 Hs. 295726 : integrin, alpha V (vitronecUn 2. 08 416448 L13210 Hs. 79339 NM005567 : Homo sapiens Pectin, gatactosi 2. 08 428727 AF078847 Hs. 191356 NM001515 : Homo sapiens genera ! transcrip 2. 08 410301 AW502935 Hs. 740 Hs. 740 : PTK2 protein tyrosine kise 2 2. 08 449538 Api559444 Hs. 104679 Hs. 104679 : Homo sapiens, clone MGC : 18216 2. 08 421205 AL137540 Hs. 102541 Hs. 102541 : netrin 4 2. 08 411779 AA292811 Hs. 72050 Nom003551 : Homo sapiens non-metastatic ce 2. 08 427704 AW971063 Hs. 292882 Hs. 292882 : ESTs 2. 07 413518 BE149455 Hs. 75415 NM 004048 : Homo sapiens beta-2-microglobu 2. 07 447345 BE247767 Hs. 18166 Hs. 18166 : KIAA0870 protein 2. 07 407143 C14076 Hs. 332329 Hs. 332329 : EST 2. 07 448431 BE613061 Hs. 337772 Hs. 337772 : hypothetica) protein BC009331 2. 07 412760 AW379030 Hs. 41324 Hs. 41324 : ESTs 2. 07 446859 A1494299 Hs. 16297 NM005694 : HomosapiensCOX17homolog, cy 2. 07 403966 2. 07 409115 A1223335 Hs. 50651 NM_002227 : Homo sapiens Janus kise I (a p 2. 07 436823 AW749865 Hs. 117077 Hs. 117077 : zinc finger protein 264 2. 07 414045 Nom002951 Hs. 75722 NM002951 : Homo sapiens ribophorin 11 (RP 2. 06 413980 NM_002437 Hs. 75659 Nom002437 : Homo sapiens MpVl7 transgene, Z06 439414 NM 001183 Hs. 6551 NM001183 : Homo sapiens ATPase, H+ transp 2. 06 426059 BE292842 Hs. 166120 NM001572 : Homo sapiens interferon regula 2. 06 429849 U33053 Hs. 2499 NM_002741 : HomosapiensproteinkiseC-ii 2. 06 402424 2. 06 406626 X04526 Hs. 215595 Hs. 215595 : guanine nucleofide binding pro 2. 06 458911 AA373131 Hs. 24322 Hs. 24322 : ATPase, H transporting, lysoso 2. 05 426086 T94907 Hs. 188572 Hs. 188572 : ESTs 2. 05 419726 U50330 Hs. 1274 NM 006129 : Homo sapiens bone morphogeneti 2. 05 452344 Api264357 Hs. 55405 Hs. 55405 : hypothetical protein MGC16212 2. 05 442498 U54617 Hs. 8364 NM_002612 : Homo sapiens pyruvate dehydrog 2. 05 422114 AW194851 Hs. 111801 NM015908 : Homosapiensarseteresistance 2. 05 413420 AW410235 Hs. 75348 NM006263 : Homo sapiens proteasome (proso 2. 05 409430 R21945 Hs. 346735 Hs. 346735 : Homo sapiens, clone IMAGE : 3881 2. 05 409932 Api376750 Hs. 57600 Hs. 57600 : adaptor-related protein complex 2. 05 434848 BE256304 Hs. 32148 Hs. 32148 : AD-015 protein 2. 04 453852 AW961818 Hs. 374424 Hs. 374424 : ESTs 2. 04 427637 AK000816 Hs. 179986 Nom005803 : Homo sapiens ñotillin 1 (FLOT 2. 04 400264 2. 04 430016 NM 004736 Hs. 227656 NM004736 : Homo sapiens xenotropic and po 2. 04 410134 U68140 Hs. 58927 Hs. 58927 : nuclear VCP-like 2. 04 440975 AW499914 Hs. 7579 Hs. 7579 : importin 9 2. 04 432280 BE440142 Hs. 2943 NM003135 : Homo sapiens sigi recognifion 2. 04 409504 AA304961 Hs. 699 NM000942 : Homo sapiens peptidylprolyl is 2. 04 412146 M92444 Hs. 73722 NM001641 : Homo sapiens APEX nuclease (mu 2. 04 434203 BE262677 Hs. 283558 Hs. 283558 : hypothetical protein PR01855 2. 04 422754 AA316476 Hs. 171811 Hs. 171811 : adenylatekise2 2. 04 406729 AA069711 AA069711 : zm52b11. s1 Stratagenefibroblas 2. 04 413086 AA126841 Hs. 183834 Hs. 183834 : ESTs 2. 03 424340 AA339036 Hs. 7033 Hs. 7033 : ESTs 2. 03 450440 AB024334 Hs. 25001 NM_01 2479 : Homo sapiens tyrosine 3-monoox 2. 03 424662 NM002870 Hs. 151536 NM 002870 : HomosapiensRAB13, memberRAS 2. 03 415740 N80486 Hs. 39911 Hs. 39911 : Homo sapiens mR for FLJ00089 pr 2. 03 412749 AA378417 Hs. 74564 NM_003145 : Homo sapiens sigl sequence rec 2. 03 408393 AW015318 Hs. 23165 Hs. 23165 : ESTs 2. 03 421295 AW081061 Hs. 103180 Hs. 103180 : DC2 protein 2. 03 445417 AK001058 Hs. 12680 Hs. 12680 : Homo sapiens cD FLJ10196 fis, c 2. 03 414883 AA926960 Hs. 348669 NM 001826 : Homo sapiens CDC28 protein kis 2. 03 447298 BE617527 Hs. 239818 Hs. 239818 : phosphoinositide-3kise, catal 2. 02 459580 AA022888 Hs. 176065 Hs. 176065 : ESTs 2. 02 422785 A1824114 Hs. 289088 Hs. 289088 : heat shock 9OkD protein 1. alp 2. 02 452696 At826645 Hs. 211534 Hs. 211534 : Homo sapiens cD FU31665fis, 2. 02 452056 AW955065 Hs. 101150 Hs. 101150 : KIAA1949 protein 2. 02 450690 AA296696 Hs. 333418 NM014164 : HomosapiensFXYDdomain-conta 2. 02 423527 Api206965 Hs. 105861 Hs. 105861 : engulfmentandcellmoUlity3 2. 01 429545 A1824164 Hs. 356130 Hs. 356130 : ESTs 2. 01 439180 Ai393742 Hs. 199067 Hs. 199067 : v-erb-b2 erythroblastic leukem 2. 01 437193 BE259190 Hs. 289721 Hs. 289721 : growth arrest-specific 5 2. 01 436014 AF281134 Hs. 283741 Hs. 283741 : exosomecomponentRrp46 2. 01 453329 T97205 Hs. 193400 Hs. 193400 : intedeukin 6 receptor 2. 01 407347 AA829847 T23514 : seq33Z91-NIBHomosapienscDclo 2. 01 435370 Al964074 Hs. 225838 Hs. 225838 : ESTs 2. 01 430657 AA482910 Hs. 370602 Hs. 370602 : ESTs, Weakly similar to hypoth 2. 01 427157 U51166 Hs. 173824 NM_003211 : Homosapiensthymine-Dglycosy 2. 01 424833 NM003894 Hs. 153405 NM 003894 : Homo sapiens period homolog 2 2. 01 440086 NM 005402 Hs. 6906 NM 005402 : Homo sapiens v-ral simian leuk 2. 01 438543 AA810141 Hs. 192182 Hs. 192182 : ESTs 2. 01 417426 NM002291 Hs. 82124 NM002291 : Homosapienslaminin, beta1 (2. 01 412790 NM_014767 Hs. 74583 NM_014767 : Homo sapiens KIAA0275 gene pro 2. 01 445892 AV655500 Hs. 93961 Hs. 93961 : Homo sapiens mR ; cD DKFZp667D09 2. 01

TABLE 38B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 409745 MH1944-5 B1030997 AA921874 AW188822 81027862 A1347618 A1361453 A1088754 AW207491 AA077391 BG012775 BG997382 AA286833 AAl 50722 B1007625 B1027864 B1009100 B1006275 B1006270 B1031000 B1029864 B1006277 B1007627 B1006266 B1006991 81006990 B1007763 81007762 BG997377 AA150780 Bl033518 Bl027818 BG015789 Bl033807 M341445 419671 2532751 N64410 AA248866AA248779W02010 437495 65231_1 AL390180 M359908 BE 177778 BE177779 AW893733 BF756318 418869 12789 14 AA229762 AA230035 432648 1290281 AA677593AA618150AA557952 421902 276321 1 BG171436 BE079601 BE079534 AA299964 BE392717 BE883402 BE079532 BE018148 BF889427 W00396 414667 MH1944-5 B1030997 AA921874 AW188822 Bl027862 Al347618 Al361453 Al088754 AW207491 AA077391 BG012775 BG997382M286833 M150722 Bl007625 B1027864 B1009100 B1006275 B1006270 B1031000 B1029864 81006277 B1007627 B1006266 B1006991 B1006990 B1007763 81007762 BG997377 AA150780 Bl033518 Bl027818 BG015789 BI033807 AA341445 435185 1271 15_1 AW173494 Al804346 M669490 411331 1076355_1 AW837178T77002F13038 451876 2328579_1 T63141AI821021BF370092BF370127BF370060T62998 400261 23110_1 BC006097 X03066 NM 002120 M26040 AW469119 AW469127 A1299772AW518149 A1144456 AW628070 A1629032 Al358810 Al880433 Al440472 Al357070 Al865365 AW014799 Api767973 AW518041 AA909398 AW768606 439195 21979_1 AF086037 H89360 H89546 454694 1066666 1 AW936378 AW936544 AW813513 416913 924456 t AW934714 AW749864 AW749902 BE162498 BE161005 BE162499 BE161006 AA190449 AW513465 BE162500 BE161007 459362 1238130_1 AW974073T55957 TABLE 38C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entUed"The DNA sequence of human chromosome 22-Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntjjosition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_posifon 403346 8569726 Plus 92752-93015 401621 8570184 Minus 193-608 403344 8569726 Plus 70823-70990 404240 5002624 Minus 116132-116407, 116653-116922 401964 3126781 Minus 13510-13725, 13847-14015 404277 1834458 Minus 91665-91946 405121 8102330 Minus 3581&36004, 36587-36684 402493 9797670 Minus 205146-205240, 205428-205542 402121 9188523 Plus 25692-25895 402474 7547175 Minus 53526-53628, 5575555920, 57530-57757 403887 7710553 Minus 69533-69868 403328 8469086 Minus 120428-120703 401241 4827300 Minus 30503-30844, 31056-31248 401736 3219338 Plus 1771-1894 405029 7533975 Minus 37929-38224 404171 9930793 Plus 173667-173783, 176876-177055 401797 6730720 Plus 6973-7118 401234 9929642 Plus 120173-120337 404170 9930793 Plus 168836-169248 406122 9144087 Minus 30940-31386 TABLE 39A : 855 GENES UP-REGULATED IN RENAL CANCER COMPARED TO NORMAL ADULT TISSUES AND TO NON-MALIGNANT RENAL TISSUES THAT ARE LIKELY TO ENCODE PROTEINS AMENABLE TO MODULATION BY SMALL MOLECULES, PEPTIDES, OR ANTIBODIES Table 39A lists about 856 genes up-regulated in renal cancer compared to normal adult tissues and to non-malignant renal tissues that are likely to encode proteins amenable to modulation by small molecules, peptides, or antibodies. These were selected from the starting collection of 59680 probesets on the Affymetrix/Eos-Hu03 GeneChipO array as follows : the ratio of 'average'renal cancer to'average"normal adult tissues was greater than or equal to 2. 0, the ratio of'average'renal cancer to'average'non-malignant renal tissues was greater than or equal to 2. 0, the'average'renal cancer level was set to the 90th percentile value amongst various renal specimens, ihe average nommal adult Ussue level was set to the 70th percentile value amongst various non-malignant tissues, the'average'non-malignant renal tissues level was set to the 50th percentage value amongst various non-malignant renal tissues, the'average'renal cancer value was greater than or equal to 50 units, and the predicted protein contained a structural domain that is indicative of having an oncogenic function or of transducing an intracellular signal, or of being modulatable by small molecules, peptides. or antibodies (e. g. pkinase, death-domain, 7tm, phosphatase, or ion transporter). Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of tumor to normal adult tissues Pkey ExAccn UnigenelD Unigene Title R1 435013 H91923 Hs. 110024 15. 71 447768 X86400 Hs. 19520 Hs. 19520 : FXYD domain-containing ion tran 14. 07 445178 Al792241 Hs. 129614 Hs. 129614 : kidney-specific membrane prote 12. 56 432542 AW083920 Hs. 16098 Hs. 16098 : claudin 2 12. 41 443595 AF169312 Hs. 9613 NM 016109 : Homosapiensangiopoietin-like 11. 77 413719 BE439580 Hs. 75498 NM00459t : Homo sapiens small inducible c 10. 39 436878 BE465204 Hs. 47448 Hs. 47448 : ESTs 10. 18 440304 BE159984 Hs. 125395 Hs. 125395 : ESTs 9. 95 407065 Y10141 9. 58

413049 NM002151 Hs. 823 NM002151 : Homo sapiens hepsin (transmemb 9. 51 425983 AK000226 Hs. 165619 Hs. 165619 : muån and cadhenn like 8. 88 423161 AL049227 Hs. 124776 Hs. 124776 : Homo sapiens mR ; cD DKFZp564N1 8. 77 430569 AF241254 Hs. 178098 Hs. 178098 : angiotensin) converting enzym 8. 45 416768 AA363733 Hs. 1032 NM002909 : Homo sapiens regenerating isle 7. 94 422357 AF016272 Hs. 115418 NM_004062 : Homo sapiens cadherin 16, KSP-7. 78 420737 L08096 Hs. 99899 NM001252 : Homo sapiens tumor necrosis fa 7. 78 409745 AA077391 AA077391 : 7B14E12Chnomosome7FetaBrai 7. 74 413936 AF113676 Hs. 297681 NM000295 : Homosapienssenne (orcystei 7. 32 426682 AV660038 Hs. 2056 Hs. 2056 : UDPglyaosyltransferase 1 family 7. 20 406851 AA609784 Hs. 352392 Hs. 352392 : major histocompaUbilib aompl 7, 03 419508 AW997938 Hs. 90786 Hs. 90786 : ATP-binding cassette, sub-famit 6. 57 428953 AA306610 Hs. 348183 NM_003823 : Homo sapiens tumor necrosis fa 6. 36 436895 AF037335 Hs. 5338 NM_001218 : Homo sapiens carbonic anhydras 6. 31 431842 NM_005764 Hs. 271473 NM_005764 : Homo sapiens epithelial protei 6. 20 430014 H59354 Hs. 374303 Hs. 374303 : hypotheticai protein MGC20576 6. 20 423803 NM005709 Hs. 132945 NM005709 : Homo sapiens PDZ-73 protein (P 6. 19 434779 AF153815 Hs. 50151 Hs. 50151 : potassiuminward) y-rectifyingc 6. 11 435767 H73505 Hs. 117874 Hs. 117874 : ESTs 6. 08 422664 AA315933 Hs. 120879 Hs. 120879 : Homo sapiens, clone MGC : 32871 6. 02 425280 U31519 Hs. 1872 Hs. 1872 : phosphoenolpyruvatecarboxykise 5. 81 426559 AB001914 Hs. 170414 NM_002570 : Homo sapiens paired basic amin 5. 73 451564 AU076698 Hs. 132760 NM_001467 : Homo sapiens glucose-6-phospha 5. 69 418526 BE019020 Hs. 85838 NM_004207 : Homo sapiens solute carrier fa 5. 68 444151 AW972917 Hs. 128749 Hs. 128749 : alpha-methylacyl-CoA racemase 5. 66 426471 M22440 Hs. 170009 NM_003236 : Homo sapiens transforming grow 5. 48 432579 AF043244 Hs. 278439 NM_003946 : Homo sapiens nucleolar protein 5. 45 448733 NM 005629 Hs. 187958 NM_005629 : Homo sapiens solute carrier fa 5. 42 446650 AB016625 Hs. 15813 NM_003060 : Homo sapiens solute carrier fa 5. 36 417089 H52280 Hs. 18612 Hs. 18612 : Homo sapiens cD FLJ21909 fis. 5. 35 437848 Api906419 Hs. 284380 Hs. 284380 : gamma-glutamyltransferase 1 5. 32 423081 AF262992 Hs. 123159 Hs. 123159 : sperm associated antigen 4 5. 30 421893 NM 001078 Hs. 109225 NM001078 : Homo sapiens vascular cell adh 5. 23 435886 BE265839 Hs. 12126 Hs. 12126 : hepatocellularcarcinoma-associ 5. 20 410276 A1554545 Hs. 359201 Hs. 359201 : ESTs 5. 20 429451 BE409861 Hs. 202833 NM_002133 : Homo sapiens heme oxygese (dec 5. 14 446404 AA019961 Hs. 26216 Hs. 26216 : Homo sapiens cD : FLJ22811 fis, 5. 13 423445 NM_014324 Hs. 128749 NM014324 : Homo sapiens alpha-methylacyl-5. 09 449444 AW818436 Hs. 351306 NM004696 : Homo sapiens solute carrier fa 5. 05 438106 BE245551 Hs. 6079 NM014863 : Homo sapiens B cell RAG associ 5. 02 400419 AF084545 AF084545 : Homo sapiens versican Vint isof 5. 01 453920 Api133148 Hs. 36602 NM_000204 : Homo sapiens I factor (complem 4. 99 447881 BE620886 Hs. 355279 Hs. 355279 : Homo sapiens cD FLJ23711 fis, 4. 97 422253 W81526 Hs. 113882 NM_000815 : Homo sapiens gamma-aminobutyn 4. 93 439024 R96696 Hs. 35598 Hs. 35598 : ESTs 4. 88 414799 A1752416 Hs. 77326 NM000598 : Homo sapiens insulin-like grow 4. 80 426530 U24578 Hs. 278625 NM_000592 : Homo sapiens complement compon 4. 77 410055 AJ250839 Hs. 58241 Hs. 58241 : gene for sedne/threonine prote 4. 72 404240 4. 71 414617 A1339520 Hs. 288817 Hs. 288817 : hypothetical protein FLJ22761 4. 68 448249 AW855331 Hs. 337124 Hs. 337124 : ESTs 4. 67 447818 W79940 Hs. 21906 Hs. 21906 : Homo sapiens clone 24670 mR seq 4. 66 449057 AB037784 Hs. 22941 Hs. 22941 : KIAA1363protein 4. 66 422424 Al186431 Hs. 296638 NM004864 : Homo sapiens prostate differen 4. 62 417336 R70429 Hs. 81988 NM001343 : Homo sapiens disabled homolog 4. 62 425873 NM013390 Hs. 160417 Nom013390 : Homo sapiens transmembrane pro 4. 58 444700 Nom-003645 Hs. 11729 NM_003645 : Homo sapiens fatty-acid-Coenzy 4. 58 414998 NM 002543 Hs. 77729 NM 002543 : Homo sapiens oxidised low dens 4. 56 414763 U97276 Hs. 77266 NM_002826 : Homo sapiens quiescin Q6 (QSCN 4. 48 443358 H65417 Hs. 17757 Hs. 17757 : pleckstin homology domain-cont 4. 45 440091 Api767388 Hs. 37890 Hs. 37890 : Homo sapiens, clone IMAGE : 48275 4. 43 447131 NM004585 Hs. 17466 NM004585 : Homo sapiens (efinoic acid rec 4. 43 406973 M34996 Hs. 198253 Hs. 198253 : major histocompatibility compl 4. 42 427740 BE242604 Hs. 180616 NM_005505 : Homo sapiens CD36 antigen (col 4. 40 436258 AW867491 Hs. 107125 Hs. 107125 : plasmalemma vesicle associated 4. 38 452884 C05964 Hs. 31841 Hs. 31841 : ESTs 4. 37 444006 BE395085 Hs. 10086 Nom016639 : Homosapiensbpel jransmembr 4. 36 422627 BE336857 Hs. 118787 NM_000358 : Homo sapiens transforming grow 4. 35 418054 NM002318 Hs. 83354 NM002318 : Homo sapiens lysyl oxidase-lik 4. 34 419011 H56244 Hs. 89552 NM000846 : Homo sapiens glutathione S-tra 4. 34 404277 4. 33 435563 AF210317 Hs. 95497 Hs. 95497 : solute carrier family 2 (facili 4. 30 431779 AW971178 Hs. 268571 NM_001645 : HomosapiensapolipoproleinC-4. Z9 406645 M57466 Hs. 814 Hs. 814 : major histocompabbility complex, 4. 28 421485 AA243499 Hs. 104800 Hs. 104800 : hypothetical protein FU10134 4. 26 426812 AF105365 Hs. 172613 NM006598 : Homo sapiens so) ute earner fa 4. 25 407910 AA650274 Hs. 41296 NM_013281 : Homo sapiens fibronectin leuci 4. 22 438030 X98427 Hs. 122634 Hs. 122634 : ESTs 4. 22 430661 AC005551 Hs. 130714 Hs. 130714 : ESTs, Moderately similar to AF 4. 21 444381 BE387335 Hs. 283713 Hs. 283713 : hypolheúca'protein BC014245 4. 20 438203 BE540090 Hs. 7345 Hs. 7345 : MAD1mitoticarrestdeficient-li 4. 16 411358 R47479 Hs. 94761 Hs. 94761 : KIAA1691 protein 4. 15 418323 NM_002118 Hs. 1162 NM_002118 : Homo sapiens major histocompat 4. 12

449853 AF006823 Hs. 24040 NM002246 : Homo sapiens potassium channel 4. 11 415198 AW009480 Hs. 943 NM 004221 : Homo sapiens tural killer cell 4. 11 418751 BE389014 Hs. 372548 Hs. 372548 : phosphoinosiUde-3-kise, regul 4. 09 414166 AW888941 Hs. 75789 NM006096 : Homo sapiens N-myc downstream 4. 07 424125 M31669 Hs. 1735 Hs. 1735 : inhibin, beta B (actvin AB beta 4. 00 416926 H03109 Hs. 263395 Hs. 263395 : sema domain, transmembrane dom 3. 92 419175 AW270037 Hs. 362996 Hs. 362996 : KIAA0779 protein 3. 92 424218 AF031824 Hs. 143212 NM_003650 : Homo sapiens cystafin F (leuko 3. 91 412870 N22788 Hs. 82407 Hs. 82407 : chemokine (C-X-C motif) ligand 3. 88 452203 X57522 Hs. 352018 NM000593 : Homo sapiens transporter 1, AT 3. 87 446872 X97058 Hs. 16362 NM 004154 : Homo sapiens pyrimidinergic re 3. 87 449961 AW265634 Hs. 133100 Hs. 133100 : ESTs 3. 87 424517 Api539443 Hs. 137447 Hs. 137447 : Homo sapiens cD FLJ12169 fis, 3. 86 425262 D87119 Hs. 155418 Hs. 155418 : GS3955 protein 3. 83 443639 BE269042 Hs. 9661 Nom002801 : Homo sapiens proteasome (proso 3. 82 448133 AA723157 Hs. 73769 NM000802 : Homo sapiens Mate receptor 1 3. 81 418030 BE207573 Hs. 83321 Hs. 83321 : neuromedin 8 3. 81 412939 AW411491 Hs. 75069 NM_005412 : Homo sapiens serine hydroxymet 3. 80 409162 H25530 Hs. 50868 NM002555 : Homo sapiens solute carrier fa 3. 79 427715 BE245274 Hs. 180428 Hs. 180428 : KIAA1181 protein 3. 78 412006 AW451618 Hs. 290216 Hs. 290216 : ESTs 3. 77 430413 AW842182 Hs. 241392 NM_002985 : Homo sapiens small inducible c 3. 76 422282 AF019225 Hs. 114309 Hs. 114309 : apolipoprotein L, 1 3. 76 420747 BE294407 Hs. 99910 Hs. 99910 : phosphofructokise, platelet 3. 76 414875 H42679 Hs. 77522 NM-006120-. Homo sapiens major histocompat 3. 75 418793 AW382987 Hs. 88474 Hs. 88474 : prostaglandin-endoperoxide synt 3. 74 446291 BE397753 Hs. 14623 NM006332 : Homo sapiens interferon, gamma 3. 71 417289 D86962 Hs. 81875 Hs. 81875 : growth factor receptor-bound pr 3. 69 422672 X12784 Hs. 119129 NM_001845 : Homo sapiens collagen, type IV 3. 68 448569 BE382657 Hs. 21486 NM007315 : Homo sapiens sigl transducer a 3. 68 437270 R18087 Hs. 323769 Hs. 323769 : cisplatin resistance related p 3. 67 408452 AA054683 Hs. 192455 Hs. 192455 : ESTs, Moderately similar to hy 3. 67 443986 A1381750 Hs. 283437 Hs. 283437 : HTGN29 protein 3. 66 418869 AW516565 AW516565 : xqOldO5. xi Soaes_NHCeC cervica 3. 65 425998 AU076629 Hs. 165950 NM_002011 : Homosapienshbroblasigrowth 3. 62 428699 AW578252 Hs. 190161 NM 014020 : Homo sapiens LR8 protein (LR8) 3. 62 418299 AA279530 Hs. 83968 NM_000211 : Homosapiensinte, qrin, beta2 3. 61 432593 AW301003 Hs. 51483 Hs. 51483 : Homo sapiens, Similar to RIKEN 3. 59 415765 Nom 005424 Hs. 78824 NM005424 : Homo sapiens tyrosine kise wit 3. 58 445985 BE621800 Hs. 29444 Hs. 29444 : putative small membrane protein 3. 57 424893 AW295112 Hs. 153648 Hs. 153648 : protein tyrosine phosphatase, 3. 57 426046 AA833655 Hs. 206868 Hs. 206868 : Homo sapiens cD FLJ14056 fis, 3. 57 424415 NM001975 Hs. 146580 NM_001975 : Homo sapiens enolase 2, (gamma 3. 57 412612 NM_000047 Hs. 74131 NM000047 : Homo sapiens arylsulfatase E 3. 56 443834 Api741510 Hs. 173548 Hs. 173548 : ESTs 3. 54 431630 NM002204 Hs. 265829 NM002204 : Homo sapiens integrin, alpha 3 3. 53 418371 M13560 Hs. 84298 Hs. 84298 : CD74 antigen (invariant polypep 3. 52 444838 AV651680 Hs. 208558 Hs. 208558 : ESTs 3. 52 449378 AW664026 Hs. 59892 Hs. 59892 : ESTs. Weakly similar to alpha 5 3. 52 411393 AW797437 Hs. 69771 NM_001710 : HomosapiensB-fælor, properd 3. 50 414311 Api693547 Hs. 71746 Hs. 71746 : aminopeptdase-like 1 3. 50 415149 X12451 Hs. 78056 NM001912 : Homo sapiens cathepsin L (CTSL 3. 50 424321 W74048 Hs. 1765 Hs. 1765 : lymphocyte-specific protein tyro 3. 49 414825 X06370 Hs. 77432 NM005228 : Homo sapiens epidermal growth 3. 48 408194 AA601038 Hs. 191797 Hs. 191797 : ESTs 3. 48 410600 AW575742 Hs. 351676 Hs. 351676 : ESTs, Weakly similar to T02670 3. 47 416899 BE262645 Hs. 80420 NM002996 : Homo sapiens small inducible c 3. 47 436856 At469355 Hs. 127310 Hs. 127310 : hypotheticai protein BC014917 3. 47 419660 BE280337 Hs. 194693 NM003982 : Homo sapiens solute carrier fa 3. 47 413566 AW604451 Hs. 285814 Hs. 285814 : growth factor receptor-bound p 3. 47 412104 AW205197 Hs. 240951 Hs. 240951 : ked cuticle homolog 2 (Drosoph 3. 46 444488 AW192879 Hs. 355660 Hs. 355660 : peptide-histidine transporter 3. 46 449475 A1348027 Hs. 108557 Hs. 108557 : hypothetical protein PP1057 3. 46 412276 BE262621 Hs. 73798 NM002415 : Homo sapiens macrophage migrat 3. 45 449338 H73444 Hs. 394 NM 001124 : Homo sapiens adrenomedullin (A 3. 44 430304 AL122071 Hs. 238927 Hs. 238927 : Homo sapiens mR cD DKFZp434H1 3. 43 415388 AF018081 Hs. 78409 (locuslink) NM_030582 : Homo sapiens collag 3. 43 432210 A1567421 Hs. 273330 Hs. 273330 : agrin 3. 43 418177 N44967 Hs. 351554 Hs. 351554 : Homo sapiens cD FLJ32092 fis, 3. 42 414888 AL039185 Hs. 77558 Hs. 77558 : thyroid hormone receptor intera 3. 42 452445 AB002438 Hs. 29596 Hs. 29596 : Homo sapiens mR from chromosome 3. 41 414803 X03100 Hs. 914 Hs. 914 : majorhistocompatibiiitycomp) ex. 3. 41 419201 M22324 Hs. 1239 NM_001150 : Homo sapiens alanyl (membrane) 3. 41 445139 AB037848 Hs. 12365 Hs. 12365 : syptotagmin XIII 3. 41 435021 AA922192 Hs. 73962 Hs. 73962 : EphA7 3. 41 417259 AW903838 Hs. 81800 Hs. 81800 : chondroitinsu) sulfate proteoglyca 3. 40 439737 A1751438 Hs. 41271 Hs. 41271 : Homo sapiens mR full length ins 3. 39 410636 AA088177 Hs. 172870 Hs. 172870 : KIAA1913 protein 3. 39 431590 AB037789 Hs. 263395 Hs. 263395 : sema domain, transmembranedom 3. 38 415000 AW025529 Hs. 239812 Hs. 239812 : serologically defined breast c 3. 36 416700 AW498958 Hs. 343475 NM001909 : HomosapienscathepsinD (lyso 3. 36 440516 S42303 Hs. 161 NM_001792 : Homo sapiens cadherin 2, type 3. 35 423720 AL044191 Hs. 23388 Hs. 23388 : hypothetical protein DKFZp434F0 3. 32

421902 BE392717 BE392717 : 601307571F1 NIH MGC 44Homosap 3. 32 409220 BE243323 Hs. 51233 Hs. 51233 : tumor necrosis factor receptor 3. 32 421502 AF111856 Hs. 105039 NM_006424 : Homo sapiens solute carrier fa 3. 32 416729 U46165 Hs. 1027 Nom004165 : Homo sapiens Ras-related assoc 3. 30 430302 AL137502 Hs. 238679 Hs. 238679 : Rag D protein 3. 30 445084 H38914 Hs. 250848 Hs. 250848 : HomosapienscDFW14761hs, 3. 29 406825 A1982529 Hs. 84298 Hs. 84298 : CD74 antigen (invarianl polypep 3. 29 446272 BE268912 Hs. 14601 NM_005335 : Homo sapiens hematopoieticce) 3. 28 437145 AF007216 Hs. 5462 NM 003759 : Homo sapiens solute camer fa 444071 A1627808 Hs. 110524 Hs. 110524 : ESTs 3. 27 414662 AL036058 Hs. 76807 Hs. 76807 : major hislocompalibility comple 436576 A1458213 Hs. 77542 Hs. 77542. ESTs, Weakly similar to S26650 3. 26 424675 NM 005512 Hs. 151641 NM 005512 : Homo sapiens glycoprotein A re 3. 25 437897 AA770561 Hs. 146170 Hs. 146170 : hypotheficalprotein FU22969 3. 25 449703 H61001 Hs. 171802 Hs. 171802 : Homo sapiens, clone) MAGE : 3956 3. 25 414788 X78342 Hs. 77313 NM_003674 : Homo sapiens cyclin-dependent 3. 25 414249 A1797994 Hs. 279929 Hs. 279929 : gp25L2 protein 3. 24 430396 D49742 Hs. 241363 NM_004132 : Homo sapiens hyaturon binding 3. 23 424456 AA341017 Hs. 25549 Hs. 25549 : hypothetical protein FU20898 3. 23 452303 R27257 Hs. 57734 Hs. 57734 : G protein-coupled receptor kise 3. 22 425390 A1092634 Hs. 156114 NM004648 : Homosapiensproteintyrosine 3. 21 416033 NM 012201 Hs. 78979 NM_012201 : Homo sapiens golgi apparatus p 3. 19 450931 N25156 Hs. 25648 Hs. 25648 : tumor necrosis factor receptor 3. 19 428065 A1634046 Hs. 157313 Hs. 157313 : ESTs 3. 18 422616 BE300330 Hs. 118725 NM012248 : Homosapiensselenophosphates 3. 18 439318 AW837046 Hs. 6527 Hs. 6527 : G protein-coupled receptor 56 3. 17 427640 AF058293 Hs. 180015 NM001355 : Homo sapiens Mopachrome taut 3. 17 409936 AK001691 Hs. 57655 Hs. 57655 : dudulin 2 3. 16 436001 AW903849 Hs. 173840 Hs. 173840 : similar to endothelial cell-se 3. 16 451154 AA015879 Hs. 33536 Hs. 33536 : ESTs 3. 16 420256 U84722 Hs. 76206 Nom001795 : Homosapienscadherin5, tpe 3. 16 407584 W25945 Hs. 8173 Hs. 8173 : hypothetical protein FLJ10803 3. 15 428593 AW207440 Hs. 185973 NM003676 : Homo sapiens degenerative sper 3. 15 410026 A1912061 Hs. 55016 Hs. 55016 : EPS8-related protein 2 3. 15 445333 BE537641 Hs. 44278 Hs. 44278 : RA817, member RAS oneogene fami 3. 14 448143 AF039704 Hs. 20478 NM 000391 : Homo sapiens ceroid-lipofuscin 3. 14 423007 AA320134 Hs. 196029 Hs. 196029 : Homo sapiens mR for KIAA1657 p 3. 14 416511 NM6762 Hs. 79356 NM 006762 : Homo sapiens Lysosomal-associa 3. 14 439237 AW408158 Hs. 318893 Hs. 318893 : ESTs, Weakly similar to Z195 H 3. 13 446899 NM 005397 Hs. 16426 NM_005397 : Homosapienspodocayxin-like 3. 13 413916 N49813 Hs. 75615 NM000483 : HomosapiensapolipoproteinC-3'3 434398 AA121098 Hs. 3838 NM006622 : Homo sapiens serum-inducible k 3. 12 441283 AA927670 Hs. 131704 Hs. 131704 : ESTs 3. 12 418945 BE246762 Hs. 89499 NM000698 : Homo sapiens arachidole Slipo 3. 12 418458 AA332941 Hs. 85226 NM 000235 : HomosapienslipaeA, lysosom 3. 12 408989 AW361666 Hs. 49500 Hs. 49500 : KIAA0746 protein 3. 11 436906 H95990 Hs. 181244 Hs. 181244 : moor histocompaubility compl 3. 11 411089 AA456454 Hs. 355702 Hs. 355702 : ESTs, Weakly similar to AC0048 3. 11 432990 AL036071 Hs. 279899 NM003820 : Homo sapiens tumor necrosis fa 3. 11 425009 X58288 Hs. 154151 NM 002845 : Homo sapiens protein tyrosine 3. 10 443601 A1078554 Hs. 42658 Hs. 42658 : Homo sapiens cD 30167fis. c 3. 10 430603 AA148164 Hs. 247280 Hs. 247280 : chromosome 20 open reading fra 3. 10 413672 BE156536 Hs. 353632 Hs. 353632 : ESTs, Moderately similar to hy 3. 09 407786 AA687538 Hs. 38972 NM005727 : Homo sapiens tetraspan 1 (TSPA 3. 09 414586 AA306160 Hs. 16488 NM002298 : Homo sapiens lymphocyte cytoso 3. 08 423712 W46802 Hs. 81988 Hs. 81988 : disabled homolog 2, mitogen-res 3. 08 438552 AJ245820 Hs. 6314 NM_012410HomosapiensbpeHransmembr 3. 06 448364 T08958 Hs. 297214 Hs. 297214 : HSPC141 protein 3. 06 426437 BE076537 Hs. 169895 NM004223 : Homo sapiens ubiquitin-conjuga 3. 06 437679 NM014214 Hs. 5753 NM014214 : Homosapiensinosilol (myo)-1 (o 3. 06 422262 AL022315 Hs. 113987 NM006498 : Homo sapiens lectin, galactosi 3. 06 410480 R97457 Hs. 63984 NM001257 : Homosapienscædherin13, Hca 3. 05 435818 AA700553 Hs. 368614 Hs. 368614 : ESTs 3. 05 418883 BE387036 Hs. 1211 NM_001611 : Homo sapiens acid phosphatase 3. 05 453613 F06838 Hs. 374476 Hs. 374476 : ESTs 3. 05 408051 A1623351 Hs. 172148 Hs. 172148 : ESTs 3. 05 432278 AL137506 Hs. 274256 Hs. 274256 : hypothetical protein FW23563 3. 04 407949 W21874 Hs. 247057 Hs. 247057,. ESTs, Weakly similar to 210926 3. 04 418090 U57059 Hs. 83429 NM 003810 : Homo sapiens tumor necrosis fa 3. 04 433165 AA578904 Hs. 292437 Hs. 292437 : ESTs 3. 03 425809 AA370362 Hs. 57958 Hs. 57958 : EGF-TM7-latrophilin-related pro 3. 03 443884 N20617 Hs. 194397 Hs. 194397 : ESTs, Moderately similar to 22 3. 03 447831 A1433293 Hs. 164115 Hs. 164115 : ESTs 3. 02 413278 BE563085 Hs. 833 NMu05101 : Homo sapiens interferon-sfimul 3. 01 418870 AF147204 Hs. 89414 Hs. 89414 : chemokine (C-X-C motif), recept 3. 00 456376 AA663904 Hs. 89862 Hs. 89862 : TNFRSF1A-associated via death d 3. 00 439738 BE246502 Hs. 9598 Hs. 9598 : sema domain, immunoglobulin doma 3. 00 444416 AW288085 Hs. 11156 NM_016494 : Homo sapiens hypothetical prot 3. 00 406656 M16714 Hs. 89643 Hs. 89643 : transketolase (Wemicke-Korsako 3. 00 406826 AW516005 Hs. 84298 Hs. 84298 : CD74 antigen (invariant polypep 2. 99 418707 U97502 Hs. 87497 Hs. 87497 : butyrophilin, subfamily 3, memb 2. 99 421742 AW970004 Hs. 107528 NM016108 : Homo sapiens androgen induced 2. 99 406824 AW515961 Hs. 84298 Hs. 84298 : CD74 antigen (invariant polypep 2. 99

435605 AF151815 Hs. 4973 NM015680 : Homo sapiens hypothetical prot 2. 98 410491 AA465131 Hs. 64001 Hs. 64001 : Homosapiensclone25218mRseq 2. 98 427648 Api376722 Hs. 180062 NM_004159 : Homo sapiens proteasome (proso 2. 98 411125 AA151647 Hs. 68877 NM_000101 : Homo sapiens cytochrome b-245, 2. 98 435550 Api224456 Hs. 324507 Hs. 324507 : hypothetical protein FU20986 2. 98 429373 NM 014694 Hs. 200594 NM 014694 : Homo sapiens KIAA0605 gene pro 2. 98 445701 AF055581 Hs. 13131 NM005475 : Homo sapiens lymphocyte adapto 2. 97 414649 Api672727 Hs. 76753 NM 000118 : Homosapiensendoglin (Osler-R 2. 97 444207 A1565004 Hs. 374415 Hs. 374415 : ESTs 2. 97 423225 AA852604 Hs. 125359 NM 006288 : HomosapiensThy-1 llsurfæ 2. 97 407792 A1077715 Hs. 39384 NM014344 : Homo sapiens four jointed box 2. 97 445707 A1248720 Hs. 114390 Hs. 114390 : ESTs 2. 96 452888 AW955454 Hs. 30942 NM_004093 : Homo sapiens ephrin-B2 (EFNB2) 2. 96 418478 U38945 Hs. 1174 Hs. 1174 : cyciin-dependentkise inhibitor 2. 95 411441 AL042355 Hs. 70202 Hs. 70202 : WD repeat domain 10 2. 95 443426 AF098158 Hs. 9329 Hs. 9329 : chromosome 20 open reading frame 2. 94 450876 AF189062 Hs. 285976 Hs. 285976 : LAG1 longevity assurance homol 2. 94 426359 AA376409 Hs. 10862 Hs. 10862 : Homo sapiens cD : FW23313 fis. 2. 94 425421 L11669 Hs. 157145 NM001120 : Homosapienstetræyclineiran 2. 93 449879 H03573 Hs. 287830 Hs. 287830 : Homo sapiens mR ; cD DKFZp434E1 2. 93 454075 R43826 Hs. 16313 Hs. 16313 : Kruppel-like zinc finger protei 2. 93 421595 AB014520 Hs. 301685 Hs. 301685 : KIAA0620 protein 2. 93 457949 W69171 Hs. 334814 Hs. 334814 : hypothetical protein FLJ14868 2. 92 443987 AW163123 Hs. 10071 NM_016551 : Homo sapiens seven transmembra 2. 92 430259 BE550182 Hs. 375142 Hs. 375142 : RaIGEF-like protein 3, mouse h 2. 92 415906 A1751357 Hs. 288741 Hs. 288741 : Homo sapiens cD : FLJ22256 fis, 2. 91 429762 Api346255 Hs. 216354 NM_006913 : Homo sapiens ring finger prole 2. 91 451527 AF022813 Hs. 26518 Nom003271 : Homo sapiens transmembrane 4 s 2. 91 425356 BE244879 Hs. 155939 NM005541 : Homo sapiens inositol potyphos 2. 91 427080 AW068287 Hs. 301175 NM002872 : Homo sapiens ras-related C3 bo 2. 91 426432 AF001601 Hs. 169857 NM 000305 : Homo sapiens paraoxose 2 (PON2 2. 90 431476 BE612705 Hs. 256697 Hs. 256697 : histidine triad nucleotide bin 2. 89 406659 AA663985 Hs. 277477 Hs. 277477 : major hislocompatibility compl 2. 89 451144 AW956103 Hs. 61712 Hs. 61712 : Homo sapiens cD FW31548 fis, c 2. 89 456362 AW973003 Hs. 179909 Hs. 179909 : nuclearreceptoraoæiivator6 2. 88 426440 BE382756 Hs. 169902 Nom006516 : Homosapienssolutecarierfa 2. 88 456974 M12529 Hs. 169401 Nom000041 : Homo sapiens apolipoprotein E 2. 88 418174 L20688 Hs. 83656 Hs. 83656 : Rho GDP dissociation inhibitor 2. 88 446055 A1815981 Hs. 12909 Hs. 12909 : mucolipin 1 2. 88 423184 NM 004428 Hs. 1624 NM004428 : Homosapiensephrin-A1 (EF1), 2. 87 427700 AA262294 Hs. 180383 NM001946 : Homo sapiens dual specificity 2. 87 410668 BE379794 Hs. 159651 NM 016629 : Homo sapiens hypothetical prot 2. 87 444143 AW747996 Hs. 160999 Hs. 160999 : ESTs, Weakly similar to 178885 2. 87 407151 H25836 Hs. 301527 Hs. 301527 : ESTs, Moderately similar to un 2. 86 449349 A1825386 Hs. 352579 Hs. 352579 : Homo sapiens, chromosome 20 op 2. 86 436997 AA741151 Hs. 137323 Hs. 137323 : ESTs 2. 86 446143 BE245342 Hs. 306079 NM 013336 : Homo sapiens protein transport 2. 86 417355 D13168 Hs. 82002 Hs. 82002 : endothelin receptor type B 2. 86 431685 AW296135 Hs. 267659 NM_006113 : Homo sapiens vav 3 oncogene (V 2. 86 408877 AA479033 Hs. 130315 Hs. 130315 : ESTs 2. 85 429615 AF258627 Hs. 211562 NM 005502 : Homo sapiens ATP-binding casse 2. 85 412014 A1620650 Hs. 43761 Hs. 43761 : gap junction protein, alpha 7, 2. 84 436749 AA584890 Hs. 5302 Nom006149 : Homosapiensiecún, galælosi 2. 84 419625 U91616 Hs. 182885 NM 004556 : Homo sapiens nuclear factor of 2. 84 439941 A1392640 Hs. 18272 Hs. 18272 : solute canier family 38, membe 2. 84 436496 AA281959 Hs. 5210 NM004877 : Homo sapiens glia maturation f 2. 84 422100 A1096988 Hs. 111554 NM_005737 : HomosapiensADP-nbosylabon 2. 83 439730 AF035292 Hs. 6654 Hs. 6654 : KIAA0657 protein 2. 83 44. 7217 BE465754 Hs. 17778 NM003872 : Homo sapiens neuropilin 2 (NRP 2. 83 428343 AL043021 Hs. 12705 Hs. 12705 : similar to HYPOTHETICAL 43. 1 KD 2. 82 440524 R71264 Hs. 16798 Hs. 16798 : Homo sapiens mR ; cD DKFZp564024 2. 82 415523 AL042003 Hs. 296847 NM 003119 : Homo sapiens spastic paraplegi 2. 81 439668 A1091277 Hs. 302634 Hs. 302634 : frizz) homolog 8 (Drosophila 2. 81 414570 Y00285 Hs. 76473 NM000876 : Homo sapiens insulin-like grow 2. 80 426535 AU077012 Hs. 288582 NM_006287 : Homo sapiens Ussue factor pat 2. 80 409649 AA159216 Hs. 55505 Hs. 55505 : hypothetical protein FW20442 2. 80 406655 M21533 Hs. 277477 Hs. 277477 : major hislocompatibility compl 2. 79 415323 BE269352 Hs. 949 NM000433 : Homo sapiens neutrophil cytoso 2. 79 443195 BE148235 Hs. 193063 Hs. 193063 : HomosapienscDFW14201hs, 2. 78 451356 AA748418 Hs. 164577 Hs. 164577 : ESTs 2. 78 450708 AA376654 Hs. 350065 Hs. 350065 : Homo sapiens cD FW30534 hs, 2. 78 433681 A1004377 Hs. 200360 Hs. 200360 : Homo sapiens cD FLJ13027 fis, 2. 77 442599 AF078037 Hs. 324051 NM006663 : Homo sapiens ReIA-associated i 2. 76 414509 AW161311 Hs. 76294 NM_001780 : Homo sapiens CD63 antigen (mel 2. 76 431394 AK000692 Hs. 252351 Hs. 252351 : HERV-H LTR-associating 2 2. 76 417331 AW411297 Hs. 81972 Hs. 81972 : SHC (Src homology 2 domain cont 2. 76 415995 NM 004573 Hs. 355888 NM 004573 : Homo sapiens phospholipase C, 2. 75 414911 NM_000107 Hs. 77602 NM000107 : Homo sapiens damage-specific D 2. 75 425976 C75094 Hs. 334514 Hs. 334514 : chromosome 6 open reading fram 2. 75 407893 BE408359 Hs. 43621 Hs. 43621 : hypothetical protein MBC3205 2. 75 407903 A1287341 Hs. 154029 Hs. 154029 : bHLH factor Hes4 2. 75 416062 AA724811 Hs. 334791 Hs. 334791 : similar to neurol tetraspanin 2. 75 428494 AA233439 Hs. 184634 Hs. 184634 : hypothetical protein FU20005 2. 75

421506 BE302796 Hs. 105097 Nom-003258 : Homo sapiens thymidine kise 1, 2. 74 427581 NM 014788 Hs. 179703 Mot4788 : HomosapienstipanUtemoUf-2. 74 424527 AW138558 Hs. 334873 Hs. 334873 : carboxypepUdase M 2. 74 439578 AW263124 Hs. 350547 Hs. 350547 : nuclear receptor co-repressor/2. 74 425188 AK002052 Hs. 155071 Hs. 155071 : chromosome 20 open reading fra 2. 74 428013 AF151020 Hs. 181444 NM_016456 : Homo sapiens hypotheticM prot 2. 73 439333 AW384710 Hs. 132986 Hs. 132986 : Homo sapiens cD FU31588 fis, Z73 450935 BE514743 Hs. 355753 NM005851 : Homo sapiens tumor suppressor 2. 73 421532 AW138207 Hs. 146170 Hs. 146170 : hypotheUcal protein FLJ22969 2. 73 440502 Al824113 Hs. 78281 Hs. 78281 : regulator of G-protein sigliing 2. 73 444981 AW855398 Hs. 12210 Hs. 12210 : tumor endothelial marker 6 2. 72 439219 N33883 Hs. 41322 Hs. 41322 : ESTs 2. 72 416847 L43821 Hs. 80261 NM006403 : Homo sapiens enhancer offilam 2. 72 433179 AW362945 Hs. 162459 Hs. 162459 : ESTs 2. 72 424528 AW073971 Hs. 238954 Hs. 238954 : ESTs, Weakly similar to putati 2. 71 411213 AA676939 Hs. 69285 NM003873 : Homo sapiens neuropilin 1 (NRP 2. 70 433012 NM_004045 Hs. 279910 NM_004045 : HomosapiensATX1 anUoxidant 2. 70 425345 AU077297 Hs. 155894 Nom002827 : Homo sapiens protein tyrosine 2. 69 428923 BE047698 Hs. 188785 Hs. 188785 : ESTs 2. 69 427923 AW274357 Hs. 301406 Hs. 301406 : hypothetical protein PP3501 2. 69 446644 NM 003272 Hs. 15791 NM_003272 : Homo sapiens transmembrane 7 s 2. 69 421743 T35958 Hs. 107614 Hs. 107614 : DKFZP56411171 protein 2. 68 416207 NM 014745 Hs. 79077 NM_014745 : Homo sapiens KIAA0233 gene pro 2. 68 420372 AW960049 Hs. 293660 Hs. 293660 : geneoverexpressedinashocyt 2. 68 420542 NM 000505 Hs. 1321 Nom000505 : Homo sapiens coagulation facto 2. 67 425069 AA687465 Hs. 298184 Hs. 298184 : potassium voltage-gated channe 2. 67 418558 AW082266 Hs. 86131 NM_003824 : Homo sapiens Fas (TNFRSF6)-ass 2. 67 426251 M24283 Hs. 168383 NM000201 : Homo sapiens intercellular adh 2. 66 406701 AA780613 Hs. 62954 Hs. 62954 : (emetin, heavy polypeptide 1 2. 66 431681 AK000378 Hs. 267566 Hs. 267566 : hypotheticai protein FLJ20371 2. 66 412833 AW960547 Hs. 298262 Hs. 298262 : ribosomal protein S19 2. 66 433101 AW572317 Hs. 12082 Hs. 12082 : TIGA1 2. 66 414774 X02419 Hs. 77274 NM 002658 : Homo saoens plasminogen activ 2. 66 427868 AI360119. compHs. 181013 NM 002629 : Homo sapiens phosphoglycerate 2. 66 413929 BE501689 Hs. 75617 Hs. 75617 : collagen, type IV, alpha 2 2. 66 424762 AL119442 Hs. 183684 Hs. 183684 : eukaryofic translation initiat 2. 66 422048 NM_012445 Hs. 288126 NM012445 : Homo sapiens spondin 2, extrac 2. 65 431350 A1192528 Hs. 164537 Hs. 164537 : ESTs 2. 65 450184 W31096 Hs. 237617 Hs. 237617 : dipep6dylpeptidase 9 2. 65 419285 D31887 Hs. 89868 Hs. 89868 : KIAA0062 protein 2. 65 414217 Api309298 Hs. 279898 Hs. 279898 : Homo sapiens cD : FLJ23165 fis, 2. 64 451253 H48299 Hs. 26126 NM_006984 : Homosapiensclaudin 10 (CLDN1 2. 64 435905 AW997484 Hs. 5003 Hs. 5003 : SLIT-ROBO Rho GTPase-activating 2. 64 432581 AU076465 Hs. 278441 NM014634 : Homo sapiens KIAA0015 gene pro 2. 63 415782 AA169345 Hs. 123177 Hs. 123177 : hypothetical protein BC011406 2. 63 430223 NM002514 Hs. 235935 NM002514 : Homo sapiens nephroblastoma ov 2. 63 417526 AA568906 Hs. 82240 NM 004177 : Homo sapiens syntaxin 3A (STX3 2. 63 409956 AW103364 Hs. 727 NM_002192 : Homo sapiens inhibin, beta A (2. 63 449843 R85337 Hs. 24030 NM001860 : Homo sapiens solute carrier fa 2. 62 417389 BE260964 Hs. 82045 NM002391 : Homo sapiens midkinefneurite 2. 62 446312 BE087853 Hs. 171802 Hs. 171802 : Homo sapiens, clone IMAGE : 3956 2. 62 435099 AC004770 Hs. 4756 Hs. 4756 : flap structure-specific endonucl 2. 62 417920 S47833 Hs. 82927 Nom004037 : Homo sapiens adenosine monopho 2. 62 435702 A1033647 Hs. 121001 Hs. 121001 : Homo sapiens, clone MGC : 45521 2. 62 422959 AV647015 Hs. 349256 Hs. 349256 : paired immunoglobulin-like rec 2. 62 419938 AU076772 Hs. 1279 NM001733 : Homosapienscomplementcompon 2. 62 450954 AI904740 Hs. 25691 NM 005856 : Homo sapiens receptor (calcito 2. 61 421753 BE314828 Hs. 107911 Hs. 107911 : ATP-binding cassette, sub-fami 2. 61 443577 A1078033 Hs. 177170 Hs. 177170 : ESTs, WeaklysimilartoALU8_H 2. 61 453886 R66282 Hs. 20247 Hs. 20247 : ESTs 2. 61 421883 X55079 Hs. 1437 NM_000152 : Homosapiensglucosidase, alph 2. 60 440457 BE387593 Hs. 21321 Hs. 21321 : granule cell differentiation pr 2. 60 410295 AA741357 Hs. 356624 Hs. 356624 : ESTs 2. 59 420679 X57152 Hs. 99853 NM001436 : Homo sapiens fibrillarin (FBL) 2. 59 451558 NM001089 Hs. 26630 NM001089 : Homo sapiens ATP-binding casse 2. 59 444672 Z95636 Hs. 11669 Hs. 11669 : 1aminin, alpha 5 2. 59 408669 Al493591 Hs. 78146 Hs. 78146 : platelel/endothelial cell adhes 2. 59 426194 T50872 Hs. 2001 Hs. 2001 : thromboxane A synthase 1 (platel 2. 59 421814 L12350 Hs. 108623 NM003247 : Homo sapiens thrombospondin 2 2. 59 456371 S76825 Hs. 89695 Hs. 89695 : insulin receptor 2. 59 429098 AF030249 Hs. 196176 NM_001398 : Homo sapiens enoyl Coenzyme A 2. 59 414443 AU077268 Hs. 76144 NM002609 : Homo sapiens platelet-derived 2. 59 428484 AF104032 Hs. 184601 NM_003486 : Homo sapiens solute carrier fa 2. 59 453309 A1791809 Hs. 32949 Nom005218 : Homo sapiens defensin, beta 1 2. 59 412867 AU076861 Hs. 74637 NM_003217 : Homo sapiens testis enhanced g 2. 58 432827 Z68128 Hs. 3109 Hs. 3109 : Rho GTPae acUvaUng protein 4 2. 58 412669 AW880841 Hs. 96908 NM_006034 : Homo sapiens p53-induced prote 2. 58 412115 AK001763 Hs. 73239 Hs. 73239 : hypothetical protein FLJ10901 2. 58 452866 R26969 Hs. 268016 Hs. 268016 : Homo sapiens cD : FU21243 fis, 2. 58 435129 A1381659 Hs. 267086 Hs. 267086 : ESTs 2. 57 424482 BE268621 Hs. 149155 NM 003374 : Homosapiensvoltage-dependent 2. 57 410494 M36564 Hs. 64016 NM_000313 : Homo sapiens protein S (alpha) 2. 56 433895 A1287912 Hs. 3628 NM004834 : Homo sapiens mitogen-acbvated 2. 56

442566 R37337 Hs. 12111 Hs. 12111 : ESTs 2. 56 417640 D30857 Hs. 82353 NM006404 : Homo sapiens protein C recepto 2. 56 442622 NM 000435 Hs. 8546 NM 000435 : Homo sapiens Notch homolog 3 (2. 56 430346 AK000331 Hs. 297641 Hs. 297641 : retinob) astoma-associatedfact 2. 55 419344 U94905 Hs. 277445 Hs. 277445 : diacylglycerol kise, zeta (104 2. 55 426500 NM_014638 Hs. 170156 Nom014638 : Homo sapiens KIAA0450 gene pro 2. 55 408048 NM_007203 Hs. 42322 NM_007203 : Homo sapiens A kise (PRKA) anc 2. 55 450700 AW732799 Hs. 25348 NM_005860 : Homo sapiens follistafin-like 2. 54 417018 M16038 Hs. 80887 Nom002350 : Homo sapiens v-yes-I Yamaguchi 2. 54 419378 R24922 Hs. 90078 Hs. 90078 : nucleotide-sugar transporter si 2. 54 422451 AA310753 Hs. 42491 Hs. 42491 : ESTs, Moderately similar to hyp 2. 53 435906 Api686379 Hs. 110796 Hs. 110796 : SAR1 protein 2. 53 400231 2. 53 417849 AW291587 Hs. 82733 NM_007361 : Homo sapiens nidogen 2 (NID2), 2. 53 427380 NM 005534 Hs. 177559 NM005534 : Homo sapiens interferon gamma 2. 52 428385 AF112213 Hs. 184062 Hs. 184062 : chromosome 20 open reading fra 2. 52 438000 Api825880 Hs. 5985 Hs. 5985 : non-kise Cdc42 effector protein 2. 52 448719 AA033627 Hs. 21858 Hs. 21858 : serine (orcysteine) pmteisei 2. 52 422396 W21872 Hs. 7907 Hs. 7907 : L-fucose kise 2. 52 420787 AA564248 Hs. 351292 Hs. 351292 : Homo sapiens cD FLJ32605 fis, 2. 51 430590 AW383947 Hs. 246381 NM001251 : Homo sapiens CD68 antigen (CD6 2. 51 447026 BE313144 Hs. 324844 Hs. 324844 : hypothetical protein IMAGE3455 2. 51 439223 AW238299 Hs. 250618 Hs. 250618 : UL16 binding protein 2 2. 50 435151 AA348482 Hs. 4788 Hs. 4788 : nicatrin 2. 50 448202 AB002292 Hs. 20695 Nom014629 : Homo sapiens Rho guanine nucle 2. 50 449943 AF104266 Hs. 24212 Hs. 24212 : latrophilin 2. 50 425743 BE396495 Hs. 159428 Hs. 159428 : BCL2-associatedX protein 2. 50 444681 AJ243937 Hs. 288316 Hs. 288316 : chromosome 6 open reading fram 2. 50 421643 BE281170 Hs. 106357 Nom007126 : Homo sapiens valosin-containin 2. 50 426865 D63476 Hs. 172813 NM003899 : Homo sapiens Rho guanine nucle 2. 50 432306 Y18207 Hs. 303090 NM005398 : Homo sapiens protein phosphata 2. 49 421846 AA017707 Hs. 1432 Nom002743 : Homo sapiens protein kise C su 2. 49 421905 A1660247 Hs. 32699 Hs. 32699 : Homo sapiens, Similar to RIKEN 2. 49 419493 AF001212 Hs. 90744 NM002815 : Homo sapiens proteasome (proso 2. 49 422530 AW972300 Hs. 118110 NM004335 : Homo sapiens bone marrow strom 2. 48 442821 BE391929 Hs. 8752 NM014255 : Homo sapiens transmembrane pro 2. 48 416919 T97839 Hs. 80464 Nom006402 : Homo sapiens hepatitis B virus 2. 48 443105 X96753 Hs. 9004 NM001897 : Homo sapiens chondroiUn sulfa 2. 48 430040 AW503115 Hs. 227823 Nom014287 : Homo sapiens pM5 protein (PM5) 2. 48 428028 U52112 Hs. 182018 NM 001569 : Homo sapiens interleukin-1 rec 2. 47 424307 AW293399 Hs. 356377 Hs. 356377 : Homo sapiens, clone IMAGE : 3633 2. 46 434511 R28982 Hs. 18106 Hs. 18106 : ESTs, Weakly similar to T06291 2. 46 454390 AB020713 Hs. 56966 Hs. 56966 : KIAA0906 protein 2. 46 417785 X59812 Hs. 82568 NM_000784 : Homo sapiens cytochrome P450, 2. 46 424673 AA345051 Hs. 294092 Hs. 294092 : Homo sapiens mR full length in 2. 46 422003 AA361760 Hs. 296326 Hs. 296326 : ESTs, Weakly similar to A33533 2. 46 432126 AA865239 Hs. 37196 Hs. 37196 : putativeG protein coupled rece 2. 46 445937 Al452943 Hs. 321231 NM 003779 : Homo sapiens UDP-Gal : belaGlcc 2. 46 409354 N68188 Hs. 159472 Hs. 159472 : Homo sapiens cD : FLJ22224 fis, 2. 46 401179 2. 46 418151 AA864238. comp Hs. 83583 NM005731 : Homo sapiens actin related pro 2. 45 422648 D86983 Hs. 118893 Hs. 118893 : Melanoma associated gene 2. 45 427759 BE245578 Hs. 2200 NM005041 : Homo sapiens perfodn I (prefo 2. 45 431222 X56777 Hs. 273790 NM007155 : Homo sapiens zo pellucida glyc 2. 45 411529 AA430348 Hs. 317596 Hs. 317596 : Homo sapiens cD FU12927 fis, 2. 45 426825 AL133415 Hs. 297753 NM003380 : Homo sapiens vimentin (VIM), m 2. 45 422242 AJ251760 Hs. 273385 NM 016592 : Homo sapiens GS complex locus 2. 45 408105 AW152207 Hs. 270977 Hs. 270977 : ESTs 2. 44 426410 BE298446 Hs. 305890 Hs. 305890 : BCL2-like 1 2. 44 421064 A1245432 Hs. 101382 NM006291 : Homo sapiens tumor necrosis fa 2. 44 428157 Al738719 Hs. 198427 NM000189 : Homosapienshexokise2 (HK2 ;, 2. 44 424398 BE397787 Hs. 146393 NM014685 : Homo sapiens homocysteine-indu 2. 44 424825 AF207069 Hs. 153357 NM001084 : Homo sapiens procoliagen-lysin 2. 44 426031 AA295251 Hs. 166066 Hs. 166066 : cisplatin resistance associate 2. 43 409817 BE295464 Hs. 56607 Hs. 56607 : Williams-Beuren syndrome chromo 2. 43 429359 W00482 Hs. 2399 Nom-004995 : Homo sapiens matrix metallopro 2. 43 426761 A1015709 Hs. 172089 Hs. 172089 : pro-onaosisreceptorinducing 2. 43 429332 AF030403 Hs. 199263 NM_013233 : Homo sapiens serinethreonine 2. 43 425923 Nom005026 Hs. 162808 Nom005026 : Homo sapiens phosphoinosiXde-2. 43 432211 BE274530 Hs. 273333 Hs. 273333 : hypothetical protein FU10986 2. 43 433339 AF019226 Hs. 8036 Hs. 8036 : RA83D, member RAS oncogene famil 2. 42 420539 AA282735 Hs. 44004 Hs. 44004 : AD031 protein 2. 42 413243 AA769266 Hs. 193657 Hs. 193657 : ESTs 2. 42 435029 AF167706 Hs. 19280 Hs. 19280 : cysteine-rich motor neuron 1 2. 42 422374 AW732869 Hs. 1519 Hs. 1519 : proteinkise, cAMP-dependent, re 2. 42 444501 AW247624 Hs. 11342 NM 004148 : Homosapiens ninjunn 1 (NINJ1 2. 42 414919 AW087337 Hs. 194461 Hs. 194461 : ESTs 2. 42 419355 AA428520 Hs. 90061 NM_006667 : Homo sapiens progesterone rece 2. 42 436042 AF284422 Hs. 119178 Hs. 119178 : cavon-chlondecotransporter-2. 42 418245 AA088767 Hs. 83883 Hs. 83883 : transmembrane, prostate androge 2. 42 444215 AB033075 Hs. 10669 Hs. 10669 : development and differentiation 2. 41 408683 R58665 Hs. 46847 NM016614 : Homo sapiens TRAF and TNF rece 2. 41 423701 AA329856 Hs. 143022 Hs. 143022 : ESTs 2. 41

441783 BE313412 Hs. 7961 Hs. 7961 : Hom sapiens clone 25012 mR sequ 2. 41 428072 BE258602 Hs. 182366 NM016292 : Homo sapiens heat shock protei 2. 41 434599 AB002313 Hs. 3989 Hs. 3989 : plexin B2 2. 40 442351 W52642 Hs. 8261 Hs. 8261 : SPRY domain-containing SOCS box 2. 40 407894 AJ278313 Hs. 41143 Hs. 41143 : phospholipase C, beta 1 (phosph 2. 40 453449 W16752 Hs. 32981 Hs. 32981 : sema domain, immunoglobulin dom 2. 40 408688 A1634522 Hs. 152925 Hs. 152925 : KIAA1268 protein 2. 40 422448 AW372922 Hs. 116774 Hs. 116774 : integnn, alpha 1 2. 39 416269 AA177138 Hs. 161671 Hs. 161671 : ESTs 2. 39 452679 Z42387 Hs. 83883 Hs. 83883 : transmembrane, prostate androge 2. 38 432981 NM 002733 Hs. 3136 NM002733 : Homo sapiens protein kise, AMP 2. 38 419846 NM 015977 Hs. 285681 Hs. 285681 : Williams Beuren syndrome chrom 2. 38 422110 A1376736 Hs. 111779 Hs. 111779 : secreted protein, acidic, cyst 2. 38 413092 AA126856 Hs. 118665 Hs. 118665 : ESTs 2. 38 433969 AW207279 Hs. 271786 Hs. 271786 : ESTs, Weakly similar to PC4395 2. 37 451267 A1033894 Hs. 117865 Hs. 117865 : solute carer family 17 (anio 2. 37 447526 AL048753 Hs. 303649 NM_002982 : Homo sapiens small inducible c 2. 37 441623 AA315805 Hs. 348710 Hs. 348710 : Homo sapiens, done) MAGE : 4242 2. 37 420255 NM007289 Hs. 1298 NM 007289 : Homo sapiens membrane metallo-2. 37 409274 Nom-003930 Hs. 52644 Nom003930 : Homo sapiens src family associ 2. 36 422801 AF125672 Hs. 287994 Hs. 287994 : nuclearreceptorco-repressor 2. 36 407887 AA579668 Hs. 41072 Hs. 41072 : serine (or cysteine) proteise i 2. 36 408212 AA297567 Hs. 43728 NM015696 : Homo sapiens weakly similar to 2. 36 430478 NM014349 Hs. 241535 NM_01U49 : HomosapiensapolipoproteinL, 2. 36 405102 2. 35 423583 AL122055 Hs. 129836 Hs. 129836 : KIAA1028 protein 2. 35 426125 X87241 Hs. 166994 NM005245 : HomosapiensFATtumorsuppres 2. 35 425204 NM002436 Hs. 1861 NM 002436 : Homo sapiens membrane protein, 2. 35 420676 Api434780 Hs. 4248 Hs. 4248 : Homo sapiens PP3781 mR, complete 2. 35 421079 AW404994 Hs. 101695 Hs. 101695 : NCK adaptor protein 2 2. 35 410039 AF207989 Hs. 58014 Hs. 58014 : G protein-coupled receptor, fam 2. 34 412958 BE391579 Hs. 75087 NM 006712 : Homo sapiens FAST kise (FASTK) 2. 34 430363 M28713 Hs. 274464 NM000398 : Homo sapiens diaphorase (DH) (2. 34 425397 J04088 Hs. 156346 NM_001067 : Homo sapiens topoisomerase (D) 2. 34 451035 AU076785 Hs. 430 NM 002670 : HomosapiensplaUn1 (1isof 2. 34 449027 AJ271216 Hs. 22880 Hs. 22880 : dipepfidylpepGdase 111 2. 34 429457 BE243065 Hs. 202955 Hs. 202955 : hypotheticat protein FLJ20507 2. 34 417709 D87434 Hs. 82426 NM_014734 : Homo sapiens K) AA0247 gene pro 2. 34 412805 AW954569 Hs. 278675 Hs. 278675 : bromodomain-containing 4 2. 34 427647 W19744 Hs. 180059 Hs. 180059 : Homo sapiens cD FLJ31360 fis, 2. 34 430702 U56979 Hs. 278568 Nom000186 : Homo sapiens H factor 1 (compl 2. 33 456804 A1421645 Hs. 139851 NM 001233 : Homo sapiens caveolin 2 (CAV2) 2. 33 453648 W21493 Hs. 28329 Hs. 28329 : protein phosphatase 1, regulato 2. 33 450812 AB002360 Hs. 25515 Hs. 25515 : MCF. 2 cell line derived transfo 2. 33 402575 2. 33 424670 W61215 Hs. 116651 NM 005797 : Homo sapiens epithelial V-like 2. 32 452960 AK001335 Hs. 31137 NM006504 : Homo sapiens protein tyrosine 2. 32 442968 AK000606 Hs. 8868 NM 004871 : Homo sapiens golgi SP receptor 2. 32 410639 BE269047 Hs. 65234 Hs. 65234 : DEAD/H (AspGlu-Ala-Asp/His) bo 2. 32 415169 W42913 Hs. 78089 NM004231 : Homo sapiens ATPase. H+transp 2. 32 450160 BE048099 Hs. 183738 Hs. 183738 : FERM, RhoGEF (ARHGEF) and plec 2. 32 407223 H96850 H96850 : yw03b12. sl Soares melanocyle 2NbH 2. 32 426780 BE242284 Hs. 172199 NM 001114 : Homosapiensædenylatecyclase 2. 32 434987 AW975114 Hs. 371677 Hs. 371677 : ESTs 2. 32 416354 NM000633 Hs. 79241 NM000633 : Homo sapiens B-cell CLLAympho 2. 31 453107 NM 016113 Hs. 279746 NM_016113 : Homo sapiens transient recepto 2. 31 422963 M79141 Hs. 13234 Hs. 13234 : ESTs, Weakly similar to hypothe 2. 31 433618 AA602539 Hs. 345494 Hs. 345494 : ESTs, Moderately similar to ZN 2. 31 438584 AA811347 AA811347 : ob81hO6. s1 NCI CGAP GCB1 Homos 2. 31 446126 AW085909 Hs. 356618 Hs. 356618 : ESTs. Weakly similar to PC4259 2. 31 408716 At567839 Hs. 151714 Hs. 151714 : peroxisomal proliferaor-æUv 2. 30 433230 AW136134 Hs. 220277 Hs. 220277 : ESTs, Weakly similar to expres 2. 30 410168 AW834050 Hs. 351432 Hs. 351432 : tensin 2. 30 446342 BE298665 Hs. 14846 Hs. 14846 : Homo sapiens mR ; cD DKFZp564D01 2. 30 418452 BE379749 Hs. 85201 NM_005127. Homo sapiens Gtype (calcium d 2. 30 453175 NM 006834 Hs. 32217 NM 006834 : Homo sapiens RAB32, member RAS 2. 29 409012 AL117435 Hs. 49725 Hs. 49725 : DKFZP4341216 protein 2. 29 452848 A1417193 Hs. 288912 Hs. 288912 : BBP-like prolein 2 2. 29 418838 AW385224 Hs. 35198 Hs. 35198 : ectonucleofide pyrophosphatase/2. 29 422562 AI962060 Hs. 118397 NM_001129 : Homo sapiens AE binding protei 2. 28 432828 AB042326 Hs. 287402 Hs. 287402 : chondroitin 4-sulfotransferase 2. 28 412948 BE243313 Hs. 334851 NM006148 : Homo sapiens LIM and SH3 prote 2. 28 426068 AF029778 Hs. 166154 NM_002226 : Homosapiensjagged2 (JAG2), 2. 28 456919 NM003900 Hs. 182248 NM Homosapienssequestosomel (S 2. 28 452806 AW014549 Hs. 58373 Hs. 58373 : ESTs 2. 28 453983 H94997 Hs. 16450 Hs. 16450 : ESTs 2. 28 407736 N41744 Hs. 349326 Hs. 349326 : HomosapienscDFW30677hs, 2. 28 413211 AW967107 Hs. 109274 Hs. 109274 : hypothetica) protein MGC4365 2. 28 422051 AW327546 Hs. 111024 Hs. 111024 : solute carrier family 25 (mito 2. 27 438438 AA257992 Hs. 50651 Hs. 50651 : Janus kise 1 (a protein tyrosin 2. 27 436278 BE396290 Hs. 5097 NM_004710 : Homo sapiens syptogynn 2 (SYN 2. 27 454080 Api199711 Hs. 576 NM_000147 : HomosaPienstucosidase, apha 2. 27 426542 AF190746 Hs. 170310 NM-017424 : Homo sapiens cat eye syndrome 2. 27

417115 AW952792 Hs. 334612 NM003094 : Homosapienssmallnuclearnb 2. 27 402901 2. 26 412898 A1129903 Hs. 74669 NM006634 : Homo sapiens vesicle-associate 2. 26 413020 R98736 R98736 : yr31hO9. r1 Soaresfetalliverspi 2. 26 413939 AL047051 Hs. 199961 Hs. 199961 : ESTs, Weakly similar to hypoth 2. 26 408681 AW953853 Hs. 281462 Hs. 281462 : hypotheticat protein FU14251 2. 25 412330 NM005100 Hs. 788 NM005100 : Homo sapiens A kise (PRKA) anc 2. 25 442083 R50192 Hs. 165062 Hs. 165062 : ESTs 2. 25 418271 NM_000919 Hs. 83920 NM_000919 : Homo sapiens peptidylglycine a 2. 25 433376 Api249361 Hs. 74122 NM001225 : Homo sapiens caspase 4, apopto 2. 25 438562 A1566826 Hs. 25890 Hs. 25890 : ESTs, Weakly similar to transdu 2. 25 443883 AA114212 Hs. 9930 Nom001235 : Homo sapiens serine (or cystei 2. 25 416976 BE243985 Hs. 80680 Hs. 80680 : major vault protein 2. 24 416914 AA344481 Hs. 80426 Hs. 80426 : brain and reproductive organ-ex 2. 24 400288 X06256 Hs. 149609 NM_002205 : Homo sapiens integrin, alpha 5 2. 24 407904 W44735 Hs. 107260 Hs. 107260 : putaUve UDP-Galc : polypeptide 2. 24 429690 AW956329 Hs. 23721 Hs. 23721 : ESTs 2. 24 443813 AA876372 Hs. 93961 Hs. 93961 : HomosapiensmR ; cDDKFZp667D09 2. 24 427458 BE208364 Hs. 29283 Hs. 29283 : ESTs, Weakly similar to LKHU pr 2. 24 454294 AB000734 Hs. 50640 NM003745 : Homo sapiens JAK binding prote 2. 24 407192 AA609200 Hs. 366318 Hs. 366318 : ESTs 2. 23 425751 T19239 Hs. 1940 NM_001885 : Homo sapiens crystallin, alpha 2. 23 456437 A1924228 Hs. 115185 Hs. 115185 : ESTs 2. 23 413019 BE281604 Hs. 75140 NM 002337 : Homo sapiens low density lipop 2. 23 418862 BE550964 Hs. 89399 Hs. 89399 : ATP synthase, H+transporting, 2. 23 435284 AA879470 Hs. 96849 Hs. 96849 : HomosapienscDFW11492hs, c 2. 23 429630 M85289 Hs. 211573 NM_005529 : Homo sapiens heparan sulfate p 2. 23 427609 AK000436 Hs. 179791 Hs. 179791 : RAB20, member RAS oncogene fam 2. 23 421917 AB028943 Hs. 109445 Hs. 109445 : hypermethylated in cancer 2 2. 23 446616 R65964 Hs. 334873 Hs. 334873 : carboxypepfidase M 2. 23 407232 X04526 X04526 : Human liver mR for beta-subunit s 2. 23 423798 AF047033 Hs. 132904 Hs. 132904 : sotute carrier famiiy 4. sodiu 2. 23 446755 AW451473 Hs. 16134 NM005990 : Homo sapiens serine/lhreonine 2. 22 452865 A1924046 Hs. 119567 Hs. 119567 : ESTs, Weakly similar to ALUI-H 2. 22 431393 AW971493 Hs. 134269 Hs. 134269 : ESTs, Weakly similar to 200439 2. 22 431890 X17033 Hs. 271986 NM002203 : Homo sapiens integrin, alpha 2 2. 22 428782 X12830 Hs. 193400 Nom000565 : Homo sapiens interleukin 6 rec 2. 22 446006 Nom-004403 Hs. 13530 NM004403 : Homo sapiens deafness, autosom 2. 22 436418 AJ245874 Hs. 4245 Hs. 4245 : chromosome 11 hypoiheUcal prole 2. 22 423869 BE409301 Hs. 134012 NM006688 : Homo sapiens Ctq-related facto 2. 21 437730 AW071087 Hs. 239176 Hs. 239176 : insulin-like growth factor 1 r 2. 21 444020 R92962 Hs. 35052 Hs. 35052 : ESTs 2. 21 413882 AA132973 Hs. 184492 Hs. 184492 : Homo sapiens mR ; cD DKFZp667B0 2. 21 412654 A1093480 Hs. 374319 Hs. 374319 : ESTs 2. 21 448988 Y09763 Hs. 22785 NM_004961 : Homo sapiens gamma-aminobutyri 2. 21 426841 A1052358 Hs. 131741 Hs. 131741 : ESTs 2. 21 408196 AL034548 Hs. 43627 NM 006941HomosapiensSRY (sexdetemmin 2. 21 451711 AK000461 Hs. 26890 Hs. 26890 : cat eye syndrome chromosome reg 2. 20 414325 AA251929 Hs. 355341 Hs. 355341 : Homo sapiens, done ! MAGE : 3536 2. 20 424512 X53002 Hs. 149846 NM_002213 : Homosapiensintegnn, betaS Z20 448883 BE614989 Hs. 7503 Hs. 7503 : hypothetical protein FU14153 2. 20 411296 BE207307 Hs. 10114 Hs. 10114 : growth suppressor 1 2. 20 452268 NM 003512 Hs. 28777 NM_00351ZHomosapiensHZAhistonefamil 2. 20 416810 AF035606 Hs. 80019 NM 013232 : Homo sapiens programmed cell d 2. 20 441415 H21497 Hs. 7471 Hs. 7471 : 88P-like protein 1 2. 20 444212 AW503976 Hs. 10649 NM_004848 : Homo sapiens basement membrane 2. 19 428044 AA093322 Hs. 301404 NM006743 : Homo sapiens R binding motif p 2. 19 430017 AA263172 Hs. 35 NM002832 : Homo sapiens protein tyrosine 2. 19 424490 AJ278016 Hs. 55565 Hs. 55565 : ankyhn repeat domain 3 2. 19 431193 AW749505 Hs. 296770 Hs. 296770 : KIAA1719 protein 2. 19 453686 AL110326 Hs. 304679 Hs. 304679 : ESTs, Weakly similar to Z195H 2. 19 448262 AW880830 Hs. 186273 Hs. 186273 : ESTs 2. 19 416065 BE267931 Hs. 78996 NM002592 : Homo sapiens proliferafing cel 2. 19 442045 C05768 Hs. 8078 Hs. 8078 : Homo sapiens clone FBD3 Cri-du-c 2. 19 423804 AW403448 Hs. 1706 NM006084 : Homo sapiens interferon-stimul 2. 19 428024 Z29067 Hs. 2236 Hs. 2236 : NIMA (never in mitosis gene ayr 2. 19 424503 NM002205 Hs. 149609 NM002205 : Homo sapiens integrin, alpha 5 2. 19 437696 Z83844 Hs. 5790 Hs. 5790 : hypothetical protein dJ37E16. 5 2. 18 405204 2. 18 426158 NM 001982 Hs. 199067 Nom-001982 : Homo sapiens v-erb-b2 erythrob 2. 18 417418 NM002468 Hs. 82116 Nom002468 : Homo sapiens myeloid different 2. 18 412773 H15785 Hs. 74573 NM012268 : Homo sapiens similar to vaccin 2. 18 409402 AF208234 Hs. 695 NM 000100 : HomosapienscystaSnB (steh 2. 18 443791 N64458 Hs. 143345 Hs. 143345 : ESTs 2. 18 435049 AL122067 Hs. 4746 Hs. 4746 : hypothetical protein FLJ21324 2. 18 418389 AA830613 Hs. 293849 Hs. 293849 : ESTs 2. 18 450712 A1732130 Hs. 270496 Hs. 270496 : ESTs, Weakty similar to ALUB H 2. 18 422007 A1739435 Hs. 39168 Hs. 39168 : ESTs, Weakly similar to T17340 2. 18 453676 AW853745 Hs. 286035 Hs. 286035 : hypothetical protein FU22686 2. 18 415718 F30631 Hs. 200237 Hs. 200237 : ESTs 2. 18 452688 AA721140 Hs. 49930 Hs. 49930 : ESTs, WeaklysimilartoB34087 2. 18 415988 BE407713 Hs. 78943 NM_000386 : Homo sapiens bleomycin hydrola 2. 18 409453 A1885516 Hs. 95612 Hs. 95612 : ESTs 2. 17

417512 X76534 Hs. 82226 NM002510 : Homosapiensg) ycoprotein (tra 2. 17 427202 BE272922 Hs. 173936 NM000628 : Homo sapiens interieukin 10 re 2. 17 440983 M20681 Hs. 7594 NM 006931 : Homo sapiens solute carrier fa 2. 17 416084 L16991 Hs. 79006 NM012145 : Homosapiensdeoxythymidylate 2. 17 429642 X68264 Hs. 211579 NM 006500 : Homo sapiens melanoma adhesion 2. 17 427213 AW007211 Hs. 348389 Hs. 348389 : hypothetical protein FU12876 2. 17 437763 AA469369 Hs. 5831 NM_003254 : Homo sapiens tissue inhibitor 2. 17 454000 AA040620 Hs. 5672 Hs. 5672 : golgi membrane protein S8140 2. 17 424247 X14008 Hs. 234734 NM_000239 : Homo sapiens lysozyme (rel amy 2. 16 403857 2. 16 406648 AA563730 Hs. 277477 Hs. 277477 : major histocompatibility compl 2. 16 400265 2. 16 442379 NM 004613 Hs. 8265 NM_004613 : Homo sapiens transglutamise 2 2. 16 441892 AB028981 Hs. 8021 Hs. 8021 : KIAA1058 protein 2. 16 417446 AL118671 Hs. 82163 NM 000898 : Homo sapiens monoamine oxidase 2. 16 418386 AA361739 Hs. 84549 NM002494 : Homo sapiens DH dehydrogese (u 2. 16 414053 BE391635 Hs. 75725 NM003564 : Homo sapiens transgelin 2 (TAG 2. 16 440906 AW161556 Hs. 240170 Hs. 240170 : hypothetica) protein MGC2731 2. 16 447660 AW160386 Hs. 163667 Hs. 163667 : ESTs, Weakiy similar to CA1HH 2. 16 408279 AF216965 Hs. 44095 Hs. 44095 : cyclin M3 2. 16 426152 BE299190 Hs. 167246 Hs. 167246 : P450 (cytochrome) oxidoreducla 2. 16 437952 D63209 Hs. 5944 NM_014585 : Homo sapiens solute carrier fa 2. 16 415661 AF057307 Hs. 78575 Hs. 78575 : prosaposin (variantGaucherdis 2. 15 425302 U79115 Hs. 155566 NM003805 : Homo sapiens CASP2 and RIPK1 d 2. 15 425996 W67330 Hs. 374451 Hs. 374451 : ESTs 2. 15 413745 AW247252 Hs. 75514 NM000270 : Homo sapiens nucleoside phosph 2. 15 422070 AF149785 Hs. 111126 Hs. 111126 : pituitary tumor-transforming 1 2. 15 448424 AW009892 Hs. 31924 Hs. 31924 : ESTs 2. 15 430035 NM003463 Hs. 227777 NM003463 : Homo sapiens protein tyrosine 2. 15 438407 A1457122 Hs. 129673 Hs. 129673 : eukaryotic translation initial 2. 15 435551 AF212365 Hs. 5470 Hs. 5470 : interleukin 17Breceptor 2. 15 437741 BE561610 Hs. 5809 Hs. 5809 : putativetransmembraneprotein ; 2. 15 441192 AA526626 Hs. 7736 NM016504 : Homo sapiens mitochondrial rib 2. 15 435750 AB029012 Hs. 4990 Hs. 4990 : KIAA1089 protein 2. 15 411165 NM 000169 Hs. 69089 NM_000169 : HomosapiensgalaCosidae, al 2. 14 425252 AW391162 Hs. 349306 Hs. 349306 : hypothetica) protein FU31951 2. 14 427600 AW630918 Hs. 179774 NM 002818 : Homo sapiens proteasome (proso 2. 14 426818 AA554827 Hs. 292996 Hs. 292996 : postmeiotic segregationincrea 2. 14 442110 AF113008 Hs. 8102 NM 001023 : Homo sapiens ribosomal protein 2. 14 407797 AK000524 Hs. 39850 Hs. 39850 : uridine kise-like 1 2. 14 443044 N28522 Hs. 8935 NM014298 : Homo sapiens quinolite phospho 2. 14 437103 AW139408 Hs. 152940 Hs. 152940 : ESTs 2. 14 442069 AW664144 Hs. 297007 Hs. 297007 : Homo sapiens cD FLJ32174 fis, 2. 14 424954 NM 000546 Hs. 1846 NM 000546 : Homo sapiens tumor protein p53 2. 14 458097 AW341135 Hs. 58104 Hs. 58104 : Homo sapiens, clone IMAGE : 47309 2. 14 411925 AW014588 Hs. 72925 NM003475 : Homo sapiens chromosome 11 ope 2. 14 449644 AW960707 Hs. 148324 Hs. 148324 : ESTs 2. 14 422675 BE018517 Hs. 119140 NM_001970 : Homo sapiens eukaryotic transl 2. 14 428586 M36712 Hs. 2299 Hs. 2299 : CD8 antigen, beta polypeptide 1 2. 14 429379 NM 014840 Hs. 200598 NM 014840 : Homo sapiens KIAA0537 gene pro 2. 13 410290 AA402307 Hs. 322844 Hs. 322844 : hypothetical protein DKFZp564A 2. 13 443895 AW979048 Hs. 292566 Hs. 292566 : YEA4 protein 2. 13 428145 BE243327 Hs. 182626 NM 012264 : Homo sapiens chromosome 22 ope 2. 13 453518 AW503205 Hs. 27268 Hs. 27268 : Homo sapiens cD : FLJ21933 fis, 2. 13 456534 X91195 Hs. 100623 Hs. 100623 : protein phosphatase 1, regulat 2. 13 419972 AL041465 Hs. 182982 Hs. 182982 : golgin-67 2. 13 424950 AA602917 Hs. 156974 Hs. 156974 : ESTs 2. 13 427557 NM 002659 Hs. 179657 NM_002659 : Homo saoens plasminogen acbv 2. 13 431449 M55994 Hs. 256278 NM_001066 : Homo sapiens tumor necrosis fa 2. 13 418758 AW959311 Hs. 172012 Hs. 172012 : hypothetical protein DKFZp434J 2. 13 434202 BE382411 Hs. 3764 NM 000858 : Homo sapiens guanylate kise 1 2. 13 433233 AB040927 Hs. 301804 Hs. 301804 : KIAA1494 protein 2. 12 452700 A1859390 Hs. 288940 Hs. 288940 : transmembrane protein 8 (five 2. 12 438033 T26483 Hs. 6059 NM016938 : Homo sapiens EGF-containing fi 2. 12 400847 2. 12 447547 NM007229 Hs. 18842 NM_007229 : Homo sapiens protein kise C an 2. 12 417052 NM 000712 Hs. 81029 NM000712 : Homo sapiens biliverdin reduct 2. 12 413284 AU077055 Hs. 289107 Nom001166 : Homo sapiens baculoviral IAP r 2. 11 434558 AW264102 Hs. 39168 Hs. 39168 : ESTs, Weakly similar to T17340 2. 11 404030 2. 11 410801 BE275469 Hs. 66493 Hs. 66493 : Downsyndromecriticairegiong 2. 11 418613 AA744529 Hs. 86575 Hs. 86575 : mitogen-activated protein kise 2. 11 447087 AW403870 Hs. 301872 Hs. 30187ZhypotheUcaproteinMGC4840 2. 11 433026 AW160616 Hs. 279921 NM 016127 : Homo sapiens hypothetical prot 2. 11 426433 L38969 Hs. 169875 NM007112 : Homosapienslhrombospondin3 2. 11 442439 U09759 Hs. 246857 NM_002752 : Homo sapiens mitogen-acfivated 2. 11 437379 AL359575 Hs. 23765 Hs. 23765 : membranemetalo-endopepUdae-2. 11 400208 2. 11 455705 AW161061 Hs. 356580 Hs. 356580 : ESTs, Weakly similar to zinc f 2. 11 417599 AA204688 Hs. 62954 Hs. 62954 : fenifin, heavy polypepUde 1 2. 10 416728 AB024597 Hs. 79658 NM 001894 : Homo sapiens casein kise 1, ep 2. 10 439920 H05430 Hs. 288433 Hs. 288433 : neurotrimin 2. 10 422309 U79745 Hs. 114924 Nom004694 : Homo sapiens solute carrier fa 2. 10

436114 AA778232 Hs. 19515 Hs. 19515 : ESTs, Highly similar to NRG3-HU 2. 10 405517 2. 10 421872 AA359753 Hs. 22824 Hs. 22824 : MYB binding protein (P160) la 2. 10 437712 X04588 Hs. 85844 Hs. 85844 : neurotrophic tyrosine kise, rec 2. 10 431214 AA294921 Hs. 348024 NM_002881 : Homo sapiens v-ral simian leuk 2. 10 412856 BE386745 Hs. 74631 Nom001728 : Homo sapiens basigin (BSG), mR 2. 10 442064 Al422867 Hs. 88594 Hs. 88594 : Homo sapiens, clone IMAGE : 43329 2. 10 434845 BE267057 Hs. 325321 Hs. 325321 : WD repeat domain 18 2. 10 426728 NM 007118 Hs. 367689 NM 007118 : Homo sapiens Wple functol d 2. 10 419596 BE379320 Hs. 91448 NM007026 : Homo sapiens dual specificity 2. 09 448913 AA194422 Hs. 22564 NM004999 : Homo sapiens myosin VI (MY06), 2. 09 414721 X90392 Hs. 77091 Nom006730 : Homo sapiens deoxyribonuclease 2. 09 424658 NM_002406 Hs. 151513 Nom002406 : Homosapiensmannosyl (alpha-1 2. 09 432805 X94630 Hs. 3107 Hs. 3107 : CD97 antigen 2. 09 447032 AK000310 Hs. 17138 Hs. 17138 : hypothetica) protein FU20303 2. 09 447484 AA464839 Hs. 292566 Hs. 292566 : YEA4 protein 2. 09 440188 AK001812 Hs. 7036 Hs. 7036 : N-acetylglucosamine kise 2. 09 445584 AF217518 Hs. 8360 Hs. 8360 : PTD012 protein 2. 09 402559 2. 09 418043 AW377752 Hs. 83341 Hs. 83341 : AXL receptor tyrosine kise 2. 09 448888 AW196663 Hs. 200242 Hs. 200242 : caspase recruitment domain fam 2. 09 436910 AA926944 Hs. 261587 Hs. 261587 : GCN2elF2aphakise 2. 09 422573 AW297985 Hs. 295726 Hs. 295726 : integrin, alpha V (vitronectin 2. 08 416448 L13210 Hs. 79339 Nom005567 : HomosapienslecUn, galælosi Z08 428727 AF078847 Hs. 191356 NM_001515 : Homo sapiens general transcrip 2. 08 410301 AW502935 Hs. 740 Hs. 740 : PTK2 protein tyrosine kise 2 Z08 449538 A1559444 Hs. 104679 Hs. 104679 : Homo sapiens, clone MGC : 18216 2. 08 421205 AL137540 Hs. 102541 Hs. 102541 : neuron 4 2. 08 411779 AA292811 Hs. 72050 NM 003551 : Homo sapiens non-metastatic ce 2. 08 427704 AW971063 Hs. 292882 Hs. 292882 : ESTs 2. 07 413518 BE149455 Hs. 75415 NM 004048 : Homo sapiens beta-2-microglobu 2. 07 447345 BE247767 Hs. 18166 Hs. 18166 : KIAA0870 protein 2. 07 407143 C14076 Hs. 332329 Hs. 332329 : EST 2. 07 448431 BE613061 Hs. 337772 Hs. 337772 : hypotheticai protein BC009331 2. 07 412760 AW379030 Hs. 41324 Hs. 41324 : ESTs 2. 07 446859 A1494299 Hs. 16297 NM_005694 : Homo sapiens COX17 homolog, cy 2. 07 403966 2. 07 409115 Api223335 Hs. 50651 NM002227 : Homo sapiens Janus kise 1 (a p 2. 07 436823 AW749865 Hs. 117077 Hs. 117077 : zinc finger protein 264 2. 07 414045 NM002951 Hs. 75722 NM_002951 : Homo sapiens dbophorin 11 (RP 2. 06 413980 NM 002437 Hs. 75659 NM002437 : Homo sapiens MpVl7 transgene, 2. 06 439414 NM001183 Hs. 6551 NM001183 : Homo sapiens ATPase, H+ lransp 2. 06 426059 BE292842 Hs. 166120 NM001572 : Homo sapiens interferon regula 2. 06 429849 U33053 Hs. 2499 NM_002741 : Homo sapiens protein kise C-li 2. 06 402424 2. 06 406626 X04526 Hs. 215595 Hs. 215595 : guanine nucleotide binding pro 2. 06 458911 AA373131 Hs. 24322 Hs. 24322 : ATPase, H+ transporting, iysoso Z05 426086 T94907 Hs. 188572 Hs. 188572 : ESTs 2. 05 419726 U50330 Hs. 1274 NM006129 : Homo sapiens bone morphogeneti 2. 05 452344 A1264357 Hs. 55405 Hs. 55405 : hypotheticai protein MGC16212 2. 05 442498 U54617 Hs. 8364 NM_002612 : Homosapienspynuvatedehydrog 2. 05 422114 AW194851 Hs. 111801 NM015908 : Homosapiensarseteresistance 2. 05 413420 AW410235 Hs. 75348 NM006263 : Homo sapiens proteasome (proso 2. 05 409430 R21945 Hs. 346735 Hs. 346735 : Homo sapiens, clone IMAGE : 3881 2. 05 409932 A1376750 Hs. 57600 Hs. 57600 : adaptor-related protein complex 2. 05 434848 BE256304 Hs. 32148 Hs. 32148 : AD-015 protein 2. 04 453852 AW961818 Hs. 374424 Hs. 374424 : ESTs 2. 04 427637 AK000816 Hs. 179986 Nom005803 : Homo sapiens flofillin 1 (FLOT 2. 04 400264 2. 04 430016 Nom004736 Hs. 227656 NM004736 : Homo sapiens xenotropic and po 2. 04 410134 U68140 Hs. 58927 Hs. 58927 : nuclearVCP-like 2. 04 440975 AW499914 Hs. 7579 Hs. 7579 : importin 9 2. 04 432280 BE440142 Hs. 2943 NM 003135 : Homo sapiens sig) recognition 2. 04 409504 AA304961 Hs. 699 NM_000942 : Homo sapiens pepfidylprolyl is 2. 04 412146 M92444 Hs. 73722 NM_001641 : Homo sapiens APEX nuclease (mu 2. 04 434203 BE262677 Hs. 283558 Hs. 283558 : hypothetical protein PR01855 2. 04 422754 AA316476 Hs. 171811 Hs. 171811 : adenylate kise 2 2. 04 406729 AA069711 AA069711 : zm52b11. sl Stratagenefibroblas 2. 04 413086 AA126841 Hs. 183834 Hs. 183834 : ESTs 2. 03 424340 AA339036 Hs. 7033 Hs. 7033 : ESTs 2. 03 450440 A8024334 Hs. 25001 NM012479 : Homo sapiens tyrosine 3-monoox 2. 03 424662 NM 002870 Hs. 151536 NM002870 : HomosapiensRAB13, memberRAS 2. 03 415740 N80486 Hs. 39911 Hs. 39911 : HomosapiensmRforFW00089pr 2. 03 412749 AA378417 Hs. 74564 NM 003145 : Homo sapiens sigl sequence rec 2. 03 408393 AW015318 Hs. 23165 Hs. 23165 : ESTs 2. 03 421295 AW081061 Hs. 103180 Hs. 103180 : DC2 protein 2. 03 445417 AK001058 Hs. 12680 Hs. 1 2680 : Homo sapiens cD FLJ10196 fis, c 2. 03 414883 AA926960 Hs. 348669 Nom001826 : Homo sapiens CDC28 protein kis 2. 03 447298 BE617527 Hs. 239818 Hs. 239818 : phosphoinositide-3-kise, catal 2. 02 459580 AA022888 Hs. 176065 Hs. 176065 : ESTs 2. 02 422785 AI824114 Hs. 289088 Hs. 289088 : heat shock 90kD protein 1 alp 2. 02 452696 AI826645 Hs. 211534 Hs. 211534 : Homo sapiens cD FLJ31665 fis, 2. 02 452056 AW955065 Hs. 101150 Hs. 101150 : KIAA1949 protein 2. 02

450690 AA296696 Hs. 333418 NM014164 : Homo sapiens FXYD domain-conta 2. 02 423527 Al206965 Hs. 105861 Hs. 105861 : engulfment and cell motility 3 2. 01 429545 A1824164 Hs. 356130 Hs. 356130 : ESTs 2. 01 439180 Api393742 Hs. 199067 Hs. 199067 : v-erb-b2eryihroblaúcleukem 2. 01 437193 BE259190 Hs. 289721 Hs. 289721 : growth arrest-specific 5 2. 01 436014 AF281134 Hs. 283741 Hs. 283741 : exosome component Rrp46 2. 01 453329 T97205 Hs. 193400 Hs. 193400 : interleukin 6 receptor 2. 01 407347 AA829847 T23514 : seq33291-NIB Homo sapiens cD clo 2. 01 435370 A1964074 Hs. 225838 Hs. 225838 : ESTs 2. 01 430657 AA482910 Hs. 370602 Hs. 370602ESTs. Weakly similar to hypoth 2. 01 427157 U51166 Hs. 173824 NM 003211 : Homosapiensthymine-Dglycosy 2. 01 424833 NM 003894 Hs. 153405 NM_003894 : Homo sapiens period homolog 2 2. 01 440086 NM005402 Hs. 6906 NM_00540ZHomo sapiens v-ra'simian leuk 2. 01 438543 AA810141 Hs. 192182 Hs. 192182 : ESTs 2. 01 417426 Nom002291 Hs. 82124 NM002291 : Homosapienslaminin, betal (2. 01 412790 NM_014767 Hs. 74583 NM014767 : Homo sapiens K) AA0275 gene pro 2. 01 445892 AV655500 Hs. 93961 Hs. 93961 : Homo sapiens mR ; cD DKFZp667D09 2. 01 TABLE 39B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 409745 MHt944 S 81030997 AA921874 AWt88822 B1027862 AI347618 AI361453 A1088754 AW207491 AA077391 8GO12775 BG997382 AA286833 AA150722 81007625 81027864 81009100 B1006275 B1006270 81031000 B1029864 B1006277 B1007627 B1006266 B1006991 B1006990 81007763 B1007762 BG997377 AA150780 Bl033518 Bl027818 BG015789 81033807 AA341445 418869 12789J4 AA229762AA230035 421902 276321_1 BG171436 BE079601 BE079534 M299964 BE392717 BE883402 BE079532 BE018148 BF889427 W00396. 400231 MH494 5 BC013310 AF261085 BC004109 AY007133 BC009081 BC001601 NM 002046 M33197 BC020308 J02642 M36164 BE794233 AV721080 BE255459 BG926429 BG389312 BG477333 A1031799 B1763443 Bl260432M989106 AV728576 B1091380 AA402499 Ai200513 A1264734 Al223995 Al289749 BG283291 BM013814 AW438544 BM450203 F35435 F33262 BE890952 AA401181 BG939668 F35525 B1088182 F34674 F33506 BM471326 F34677 AW276712 AA187508 F34866 AA114245 AA522581 N23935 A1076923 A1018505 BE879774 BM465637 AI753078 BG222159 AA595947 8F970917 81094125 AA719841 BE893087 BG775178 BE793983 BE797071 BF339134 BE409272 BE266456 BE796770 BE745957 BG755835 BE266758 BE259342 BM450181 BG748174 BE299322 BM423587 BM467637 BM452667 BM479516 BM452420 BE273297 BM466364 BM450640 BM478743 BM459094 BM455306 BM472001 BM478247 BM478771 BM480379 BM459071 BM450106 BM467584 BM464548 BM465044 BM450176 BF569359 BM462924 BM455329 8M471815 BI862301 BG331736 H04903 AA374894 BE902964 438584 1241536 1 AW977949 AA811347 D79715 413020 1485885_1 BE048113 R98736 Z42904 400265 1145-1 X58141 NM_001119 Al246786 BE645243 Al685698 Al208590 BE222576 AN 91715AI423108 BF064068 BG057819 A1208589 A1880535 AI262890 Al246261 BF939926 AI282848 AI802409 BE301053 AI884624 AI160385 AI335983 BF440017 BG231884 A1343699 A1280745 A1871338 A1123739 Ai871126 AW080375 Al350160 Al300855 A1818598 Al085263 Al306653 AW571658 BF109839 AW273280 AI888380 AI571860 AI357126 AW194105 Api131474 AW316548 AW128942 AW571682 A1583962 AW300674 BF509394 AI891077 BF221538 AI651874 F25731 AW881176 A1685962 D44936 A1753874 BF593905 BE832830 A1637970 BE834103 BE464301 A1908017 A1378261 AA975416 R16732 H47612 H45402 AA668719 AA722441 AA991443 T51951 AW514058 Al277763 M421907 Al083831 H40630 NM014190 BM469282 AL524786 AL527067 BF313768 AL042441 AL037806 81195013 BE219292 BF055534 T95785 BE833037 AV648052 AA382588 W67987 H46049 R92289 H47699 AA380016 AL532433 BG958742 Api292151 H26003 R62487 BG766512 BE815124 AW136122 H96767 R39407 B1044500 H18771 H22071 R09985 R75803 H42172 BE770251 AL529310 F03180 R92185 H18680 R43192 AA401390 AA977941 A1091944 AA993369 AA617840 H14351 AI866242 AI915028 AA780787 AA506995 AA827496 AA634305 AA846358 AA470463 AA618163 AA601963 W74212 AA021520 AA421274 AA903521 AA411402 AA044448 AA983449 AA076114 AA633470 AA581793 AA019060 AA814222 AA693469 N99931 N67840 R26834 BF342340 AA976636 AA360268 AA976223 T95786 AA527774 AI620298 AA180888 AAi49218 AA565201 81001597 BE676565 AW169797 AW190994 AA299572 A1092819 AI291438 AA459586 AA136373 R50213 BE622752 AA401414 AA180973 AA766800 W96432 Bol550308 H52236 AA491029 BG420468 BG827522 400208 16640_1 X78817 NM_001666 D50921 AW002308 AW575456 BF507511 AW467767 Api910663 BF905778 BG251264 AL562106 AI890538 AW769258 AI590391 Al913055 AW083235 A1078474 AI925022 AW504628 AW 129725 BE466589 AW002786 AW591760 A1968816 AW006268 AW593787 BG236814 AW769893 AW407608 AW075982 Al248207 Al762509 Al812070 Al249937 AW083561 AW080697 BF663046 BG745612 BG979546 AW793245 B1014177 AL519126 BE675314 AW806520 B1870778 BF879549 BE714919 BF847786 BG684161 AV695278 BG491029 BE793244 BE830893 BE798121 R09703 Bl013066 400264 1145 1 X58141 NM_001119 Al246786 BE645243 Al685698 Al208590 BE222576 Al191715 Al423108 BF064068 BG057819 AI208589 AI880535 AI262890 Al246Z61 BF939926AI282848 Al802409 BE301053 AI884624 AI 160385 AI335983 BF440017 BG231884 AI343699 AI280745 AI871338 AI123739 AI871126 AW080375 AI350160 AI3855 AI818598 A1085263 AI306653 AW571658 BF109839 AW273280 AI888380 AI571860 AI357126 AW194105 Al131474 AW316548 AW128942 AW571682 Api583962 AW300674 BF509394 AI891077 BF221538 AI651874 F25731 AW881176 Al685962 D44936 Al753874 BF593905 BE832830 Al637970 BE834103 BE464301 AI908017 AI378261 AA975416 R16732 H47612 H45402 AA668719 AA722441 AA991443 T51951 AW514058 A1277763 AA421907 A1083831 H40630 NM 014190 BM469282 AL524786 AL527067 BF313768 AL042441 AL037806 B1195013 BE219292 BF055534 T95785 BE833037 AV648052 AA382588 W67987 H46049 R92289 H47699 AA380016 AL532433 BG958742 Api292151 H26003 R62487 BG766512 BE815124 AW136122 H96767 R39407 Bol044500 H18771 H22071 R09985 R75803 H42172 BE770251 AL529310 F03180 R92185 H 18680 R43192 AA401390 AA977941 A1091944 AA993369 AA617840 H 14351 A1866242 A1915028 AA780787 AA506995 AA827496 AAM05 AA846358 AA470463 AA618163 AA601963 W74212 AA021520 AA421274 AA903521 AA411402 AA044448 AA983449 AA076114 AA633470 AA581793 AA019060 AA814222 AA693469 N99931 N67840 R26834 BF342340 AA976636 AA360268 AA976223 T95786 AA527774 A1620298 AA180888 AA149218 AA565201 BI001597 BE676565 AW 169797 AW 190994 AA299572 A1092819 AI291438 AA459586 AAt 36373 R50213 BE622752 AA401414 AA180973 AA766800 W96432 Bol550308 H52236 AA491029 BG420468 BG827522 406729 0 0 AA069711 407347 810943_1 T23514 A1655785 TABLE 39C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 404240 5002624 Minus 116132-t16407, 116653-116922 404277 1834458 Minus 91665-91946

401179 9438647 Plus 113477-113893 405102 8076881 Minus 120922-121296 402575 9884830 Minus 109742-109883 402901 8894222 Minus 175426-175667 405204 7230116 Plus 126569-126754 403857 7708910 Minus 2524-3408 400847 9188605 Plus 44643-44835 404030 7671252 Plus 149362-151749 405517 9454624 Plus 114757-114877 402559 9864273 Plus 33539-33715 403966 8568881 Plus 158193158277, 160116-160290 402424 9796344 Minus 64925-65073 TABLE 40A : ABOUT 977 GENES UP-REGULATED IN STOMACH CANCER Table 40A lists about 977 genes up-regulated in stomach cancer compared to normal adult tissues. These were selected from 59680 probesets on the Af (ymeNulEos Hu03 GeneChip array such that the ratio of'average'stomach cancer to'average* normal adult tissues was greater than or equal to 2. 0. The'average'stomach cancer level was set to the 90th percentage amongst various stomach cancers. The'average'normal adult Ussue level was set to the 90th percentage amongst various non-malignant tissues. In order to remove gene-specific background levels of non-specific hybridization, the 1 5th percenUle value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn :, Exemplar Accession number, Genbank accession number Unigenela Unigene number Unigene Tiiie : Unigene gene 60e R1 : Ratio of tumor to normal adult tissues Pkey ExAccn UnigenelD Unigene TiUe Rt 411243 AB039886 Hs. 69319 CA11 30. 66 418007 M13509 Hs. 83169 matrix metalloproteinase 1 (interstitial 16. 94 444325 AW152618 Hs. 16757 ESTs 13. 51 445891 AW391342 Hs. 199460 ESTs 11. 92 448811 Al590371 Hs. 174759 ESTs 11. 08 431723 AW058350 Hs. 16762 Homo sapiens mRNA ; cDNA DKFZp564B2062 (f 10. 84 409757 Nom-001898 Hs. 123114 cystatin SN 10. 38 421110 AJ250717 Hs. 1355 cathepsin E 9. 11 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin 8. 66 446998 N99013 Hs. 16762 Homo sapiens mRNA ; cDNA DKFZp564B2062 (f 8. 50 406687 M31126 Hs. 272620 pregnancyspecrficbeta-1-glycoprotein9 7. 11 428651 AF196478 Hs. 188401 annexin A10 6. 86 425211 M18667 Hs. 1867 progastricsin (pepsinogenC) 6. 51 423673 BE003054 Hs. 1695 matrix metalloproteinase 12 (macrophage 6. 49 409683 U33317 Hs. 711 defensin, alpha 6, Paneth cell-specific 6. 39 422260 AA315993 Hs. 105484 ESTs, Weakly similar to LITB HUMAN LITHO 6. 31 428664 AK001666 Hs. 189095 similartoSALLl (sai (Drosophila)-like 6. 25 409041 AB033025 Hs. 50081 K) AA1199 protein 5. 72 408380 AF123050 Hs. 44532 diubiquitin 5. 72 428953 AA306610 Hs. 194676 DKFZP434C013protein 5. 46 450685 L15533 Hs. 423 pancreaUUs-asociated protein 5. 40 409187 AF154830 Hs. 50966 carbamoyl-phosphate synthetae 1, mitoch 5. 34 434206 AW136973 Hs. 288516 ESTs, Weakly similar to S69890 mitogen i 5. 16 421346 Z34277 Hs. 103707 apomucin 5. 14 427585 D31152 Hs. 179729 collagen, type X, alpha 1 (Schmid metaph 5. 06 425679 X05997 Hs. 159177 lipase, gastric 4. 94 421582 Ai910275 Hs. 1406 trefoil factor 1 (breast cancer, estroge 4. 93 434414 At798376 gb : tr34bO7. x1NCI CGAP_Ov23Homosapiens 4. 92 422956 BE545072 Hs. 122579 hypothetical protein FU10461 4. 89 448105 AW591433 Hs. 170675 ESTs, Weakly similar to TMS2 HUMAN TRANS 4. 84 423575 C18863 Hs. 163443 Homo sapiens CDNA FU 11576 fis, clone HE 4. 72 413385 M34455 Hs. 840 indoleamine-pyrrole 2, 3 dioxygenase 4. 72 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 4. 68 448693 AW004854 Hs. 228320 Homo sapiens cDNA : FLJ23537 fis, clone L 4. 53 441377 BE218239 Hs. 202656 ESTs 4. 51 419278 AU076799 Hs. 1247 apolipoprotein A-IV 4. 48 407811 AW190902 Hs. 40098 cysteine knot superfamily 1, BMP antagon 4. 47 403422 4. 38 403776 4. 32 418478 U38945 Hs. 1174 cyclin-dependentkinaeinhibitor2A (me 4. 32 428242 H55709 Hs. 2250 leukemia inhibitory factor (choiinergic 4. 30 421341 AJ243212 Hs. 279611 deleted in malignant brain tumors 1 4. 30 451181 A1796330 Hs. 207461 ESTs 4. 26 432168 AK000563 Hs. 272805 hypothetical protein FLJ20556 4. 23 454464 AW811606 Hs. 271819 Homo sapiens DNA : FLJ22751 fis, clone K 4. 20 448844 A1581519 Hs. 177164 ESTs 4. 14 428434 AW363590 Hs. 65551 ESTs, WeaklysimilartoAF1729931PLUNC 4. 13 452461 N78223 Hs. 108106 transcriptionfactor 4. 08 409420 Z15008 Hs. 54451 laminin, gamma 2 (nicein (100kD), ka) inti 4. 04 431611 U58766 Hs. 264428 tissue specific transplantation antigen 4. 04 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy 4. 03 430044 AA464510 Hs. 152812 ESTs 4. 02 409956 AW103364 Hs. 727 inhibin, beta A (æUvin A, æUvin AB a 4. 01 422420 U03398 Hs. 1524 tumor necrosis factor (ligand) superfami 4. 00 420159 A1572490 Hs. 99785 HomosapienscDNA : FLJ21245 fis, clone C 3. 98 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 3. 91

422168 AA586894 Hs. 112408 S100 calcium-binding protein A7 (psorias 3. 87 452304 AA025386 Hs. 61311 ESTs, Weakly similar to S10590 cysteine 3. 84 412140 AA219691 Hs. 73625 RAB6interæUng, kinesin-like (rabkines 3. 82 414812 X72755 Hs. 77367 monokine induced by gamma interferon 3. 81 419833 AA251131 Hs. 220697 ESTs 3. 81 446232 A1281848 Hs. 165547 ESTs 3. 74 432398 AA307808 Hs. 2979 trefoil factor 2 (spasmo) ytic protein !) 3. 70 451105 Al761324 gb : wi60bil. xl NCl_CGAP_Col6Homosapiens 3. 67 413281 AA861271 Hs. 34396 ESTs 3. 66 432867 AW016936 Hs. 233364 ESTs 3. 66 424046 AF027866 Hs. 138202 serine (orcysteine) proleinaseinhibilo 3. 65 457465 AW301344 Hs. 195969 ESTs 3. 65 414918 Api219207 Hs. 72222 Homo sapiens cDNA FW 13459 hs, clone PL 3. 61 418738 AW388633 Hs. 6682 ESTs 3. 60 427778 AA412323 Hs. 105323 ESTs 3. 60 454293 H49739 Hs. 134013 ESTs, Moderately similar to NK homeobox 3. 59 452194 Al694413 Hs. 298262 ESTs, Wea'dy similar to dJ88J8. 1 lH. sapi 3. 57 442577 AA292998 Hs. 163900 ESTs 3. 57 426174 AA547959 Hs. 115838 ESTs 3. 53 452862 AW378065 Hs. 8687 ESTs 3. 51 418869 AW516565 Hs. 258279 ESTs 3. 48 430178 AW449612 Hs. 152475 ESTs 3. 48 430397 A1924533 Hs. 105607 ESTs 3. 46 418054 NM 002318 Hs. 83354 lysyl oxidase-like 2 3. 45 442295 Al827248 Hs. 224398 Homo sapiens cDNA FU 11469 fis, clone HE 3. 44 425921 NM-007231 Hs. 162211 solute carder family 6 (neurotransmitte 3. 44 431764 AA515212 Hs. 271819 HomosapienscDNA : FLJ22751 fis, clone K 3. 43 421948 L42583 Hs. 111758 keratin 6A 3. 43 444381 BE387335 Hs. 283713 ESTs, Weakly similar to CA54 HUMAN COLLA 3. 41 442896 R37725 Hs. 261108 ESTs 3. 41 452281 T93500 Hs. 28792 Homo sapiens cDNA FLJ11041 hs, clone PL 3. 39 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 3. 39 408832 AW085690 Hs. 63428 ESTs 3. 39 406685 M18728 gb : Human nonspecific crossreacfing anfig 3. 37 437527 A1241019 Hs. 145644 ESTs 3. 37 433084 M18079 Hs. 282265 fatty acid binding protein 2, intestinal 3. 37 452401 Nom007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 3. 36 441318 A1078234 Hs. 176130 ESTs 3. 35 458897 U85642 Hs. 138506 ESTs 3. 33 413808 J00287 Hs. 182183 caldesmon 1 3. 33 411274 NM 002776 Hs. 69423 kallikrein 10 3. 32 418406 X73501 Hs. 84905 cytokeratin 20 3. 32 419559 Y07828 Hs. 91096 ring finger protein 3. 32 423217 NM_000094 Hs. 1640 collagen, type VII, alpha 1 (epidemrolys 3. 31 423271 W47225 Hs. 126256 interleukin 1, beta 3. 31 411558 AA102670 Hs. 70725 gamma-aminobutyric acid (GABA) A recepto 3. 30 427722 AK000123 Hs. 180479 hypothetical protein FLJ20116 3. 30 422310 AA316622 Hs. 98370 cytochrome P540 family member predicted 3. 30 430704 AW813091 gb : RC3-ST0186-24û400~ dO7 ST0186 Homo 3. 29 411263 BE297802 Hs. 69360 kinesin-like6 (mRoUccentromere-assoc 3. 29 443211 Al128388 Hs. 143655 ESTs 3. 29 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 3. 28 441085 AW136551 Hs. 181245 Homo sapiens cDNA FL,12532 fis, clone NT 3. 28 452121 NM004081 Hs. 70936 deleted in azoospermia 3. 27 408633 AW963372 Hs. 46677 PR02000 protein 3. 27 447342 A1199268 Hs. 19322 ESTs 3. 25 419229 A1827237 Hs. 282884 ESTs 3. 24 443957 AA521049 Hs. 34487 hypothetical protein FLJ23412 3. 23 452699 AW295390 Hs. 213062 ESTs 3. 23 425188 AK002052 Hs. 155071 hypothetical protein FLJ11190 3. 23 400289 X07820 Hs. 2258 matrix metalloproteinase 10 (stromelysin 3. 21 408524 D87942 Hs. 46328 fucosyltransferase 2 (secretor status in 3. 20 437897 AA770561 Hs. 146170 hypothetical protein FLJ22969 3. 20 453922 AF053306 Hs. 36708 budding uninhibited by benzimidazoles 1 3. 19 453160 A1263307 Hs. 146228 ESTs 3. 19 406690 M29540 Hs. 220529 carcinoembryonic antigen-related cell ad 3. 19 430187 A1799909 Hs. 158989 ESTs 3. 18 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h 3. 16 447048 AW393080 Hs. 228320 Homo sapiens cDNA : FLJ23537 fis, clone L 3. 14 408113 T82427 Hs. 194101 HomosapienscDNA : FLJ20869 fis, clone A 3. 14 425465 L18964 Hs. 1904 protein kinase C, iota 3. 13 425826 U97698 Hs. 159593 mucin 6, gastric 3. 13 431662 AA513406 Hs. 152307 ESTs 3. 13 419216 AU076718 Hs. 164021 small inducible cytokine subfamily B (Cy 3. 13 418203 X54942 Hs. 83758 CDC28 protein kinase 2 3. 12 417315 A1080042 Hs. 180450 ribosomal protein S24 3. 11 433001 AF217513 Hs. 279905 cloneHCiO310PR00310p1 311 459587 AA031956 gb : zk15e04. s1 SoarespregnanLuterus NbH 3. 11 450159 AI702416 Hs. 200771 ESTs, Weakly similar to CAN2_HUMAN CALPA 3. 11 434370 AF130988 Hs. 58346 downless (mouse) homolog 3, 10 421190 U95031 Hs. 102482 mucin 5, subtype 8, tracheobronchial 3. 10 421379 Y15221 Hs. 103982 small inducible cytokine subfamily B (Cy 3. 10 420380 AA640891 Hs. 102406 ESTs 3. 10

414774 X02419 Hs. 77274 plasminogen activator, urokinase 3. 10 415989 A1267700 Hs. 111128 ESTs 3. 09 407137 T97307 Hs. 199067 v-erb-b2 avian erylhrobla5Uc leukemia v 3. 09 407289 AA135159 Hs. 203349 Homo sapiens cDNA FLJ12149 fis, clone MA 3. 09 420297 A1628272 Hs. 88323 ESTs 3. 08 447519 U46258 Hs. 23448 ESTs 3. 08 448045 AJ297436 Hs. 20166 prostate stem cell antigen 3. 07 431956 AK002032 Hs. 272245 Homo sapiens DNA 1170 (is. done PL 3. 06 410286 Api739159 Hs. 61898 DKFZP586N2124 protein 3. 05 409632 W74001 Hs. 55279 serine (or cysteine) proteinase inhibito 3. 05 454034 NM 000691 Hs. 575 aldehyde dehydrogenase 3 3. 05 436481 AA379597 Hs. 5199 HSPC150 protein similar to ubiquiGn-con 3. 05 430573 AA744550 Hs. 136345 ESTs 3. 05 428987 Nom 004751 Hs. 194710 glucosamino (N-acetyl) transferase 3, m 3. 04 424252 AK000520 Hs. 143811 hypothetical protein FLJ20513 3. 04 436291 BE568452 Hs. 5101 protein regulator of cytokinesis 1 3. 03 415992 C05837 Hs. 145807 Homo sapiens cDNA FW13593 hs, clone PL 3. 03 411789 AF245505 Hs. 72157 Homo sapiens adlican mRNA, complete cds 3. 02 417956 AA210704 Hs. 190465 ESTs 3. 02 408908 BE296227 Hs. 48915 serine/threoninehinæe 15 3. 01 422330 D30783 Hs. 115263 epiregulin 3. 01 425071 NM013989 Hs. 154424 deiodinase, iodothyronine, type ll 3. 00 425761 AW664214 Hs. 196729 ESTs 2. 99 432978 AF126743 Hs. 279884 DNAJ domain-containing 2. 99 418546 AA224827 gb : nc32gO4. s1 NCI_CGAP_Pr2 Homo sapiens 2. 99 425371 D49441 Hs. 155981 mesothelin 2. 99 422440 NM 004812 Hs. 116724 ado-ketoreductæefamilyl, memberB11 2. 98 439453 BE264974 Hs. 6566 thyroid hormone receptor interactor 13 2. 98 413278 BE563085 Hs. 833 interferon-sumulated protein, 15 kDa 2. 97 428450 NM 014791 Hs. 184339 KIAA0175 gene product 2. 95 424345 AK001380 Hs. 145479 Homo sapiens cDNA FW10518 hs, clone NT 2. 95 433133 AB027249 Hs. 104741 PDZ-binding kinase ; T-cell originated pr 2. 94 432269 Nom-002447 Hs. 2942 macrophage stimulating 1 receptor (c-met 2. 94 432917 NM014125 Hs. 279812 PR00327 protein 2. 94 433384 A1021992 Hs. 124244 ESTs 2. 93 432731 R31178 Hs. 287820 fibronectin 1 2. 93 420552 AK000492 Hs. 98806 hypothetical protein 2. 92 428303 AW974476 Hs. 183601 regulator of G-protein signalling 16 2. 92 409687 T51125 Hs. 8493 ESTs 2. 91 434377 AW137148 Hs. 136348 osteoblast specific factor 2 (fasciclin 2. 89 417791 AW965339 Hs. 111471 ESTs 2. 89 457288 AA521458 Hs. 192738 ESTs 2. 89 456181 L36463 Hs. 1030 ras inhibitor 2. 89 450190 T51387 gb : yb20eO8. rl Stratagene fetal spleen (9 2. 88 411573 AB029000 Hs. 70823 KIAA1077 protein 2. 88 430204 AA618335 Hs. 146137 ESTs, Weakly similar to putative [Celeg 2. 88 434808 AF155108 Hs. 256150 ESTs, HighlysimilarloNY-REN41anUge 2. 87 450983 AA305384 Hs. 25740 ER01 (S. cerevisiae)-like 2. 87 418670 AA601036 Hs. 285083 ESTs 2. 87 416661 AA634543 Hs. 79440 IGF-II mRNA-binding protein 3 2. 87 409723 AW885757 Hs. 257862 ESTs 2. 87 435099 AC004770 Hs. 4756 Aap structure-specific endonuclease 1 2. 86 408660 AA525775 Hs. 292523 ESTs 2. 86 434032 AW009951 Hs. 206892 ESTs 2. 85 418216 AA662240 Hs. 283099 AF I 5q 14 protein 2. 85 453331 A1240665 Hs. 8895 ESTs 2. 85 450221 AA328102 Hs. 24641 cytoskeleton associated protein 2 2. 84 402075 2. 84 410145 AW886300 gb : RC5-OT0078-100400-023-CllOT0078Homo 2. 83 410681 AW246890 Hs. 65425 calbindin 1, (28kD) 2. 83 439867 AA847510 Hs. 161292 ESTs 2. 83 443715 A1583187 Hs. 9700 cyclin E1 2. 83 420005 AW271106 Hs. 133294 ESTs 2. 83 417366 BE185289 Hs. 1076 smattprotine-rich protein IB (comifin) 2. 83 422283 AW411307 Hs. i 14311 CDC45 (cell division cycle 45, S. cerevis 2. 82 404567 2. 82 422158 L10343 Hs. 112341 protease inhibitor 3, skin-derived (SKAL 2. 82 449224 AW995911 Hs. 299883 hypothetical protein FLJ23399 2. 81 407584 W25945 Hs. 18745 ESTs 2. 81 453884 AA355925 Hs. 36232 KIAA0186 gene product 2. 81 449032 AA045573 Hs. 22900 nuclear factor (erythroid-derived 2rlik 2. 80 422809 AK001379 Hs. 121028 hypothetical protein FLJ10549 2. 79 449722 BE280074 Hs. 23960 cyclin Bl 2. 79 445676 A1247763 Hs. 16928 ESTs 2. 79 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 2. 78 453028 AB006532 Hs. 31442 RecO protein-like 4 2. 78 421777 BE562088 Hs. 108196 HSPC037 protein 2. 78 452571 W31518 Hs. 34665 ESTs 2. 77 420759 T11832 Hs. 127797 ESTs 2. 77 422675 BE018517 Hs. 119140 eukaryotictransiationinitiationfactor 2. 77 412723 AA648459 Hs. 179912 ESTs 2. 76 439670 AF088076 Hs. 59507 ESTs, Weakly similar to AC004858 3 Ui sm 2. 76 400298 AA032279 Hs. 61635 six transmembrane epithelial antigen of 2. 76

414569 AF109298 Hs. 118258 prostate cancer associated protein 1 2. 76 449378 AW664026 Hs. 59892 ESTs 2. 75 423903 M57765 Hs. 1721 intedeukin 11 2. 75 412059 AA317962 Hs. 249721 ESTs 2. 75 431104 AW970859 Hs. 269109 ESTs 2. 75 439759 AL359055 Hs. 67709 Homo sapiens mRNA full length insert cDN 2. 75 450701 H39960 Hs. 288467 Homo sapiens cDNA FW 12280 fis, clone MA 2. 75 452940 AA029722 Hs. 20279 ESTs 2. 74 408690 AW864542 gb : PM4-SN0016-120500-003hO2SN0016Homo 2. 74 407777 AA161071 Hs. 71465 squalene epoxidase 2. 73 432201 A1538613 Hs. 135657 ESTs 2. 73 414416 AW409985 Hs. 76084 lamin B2 2. 73 414617 AI339520 Hs. 20524 ESTs, Moderately similar to hexokinase 1 2. 73 432407 AA221036 Hs. 285026 HERV-H LTR-associating 1 2. 73 444301 AK000136 Hs. 10760 hypothetical protein FLJ20129 2. 72 450375 AA009647 Hs. 8850 a disinlegnn and metalloproteinae doma 2. 72 441362 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re 272 408298 A1745325 Hs. 271923 Homo sapiens cONA : FLJ22785 fis, done K 2. 72 426711 AA383471 Hs. 180669 conserved gene amplified in osteosarcoma 2. 71 429432 A1678059 Hs. 202676 synaptonemal complex protein 2 2. 71 450506 Nom-004460 Hs. 418 fibroblast activation protein, alpha 2. 71 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 2. 71 418801 AA228366 Hs. 115122 ESTs 2. 71 440283 Al732892 Hs. 190489 ESTs 2. 71 429486 AF155827 Hs. 203963 hypothetical protein FU10339 2. 71 408366 AW511255 Hs. 258082 ESTs 2. 70 406399 2. 69 434217 AW014795 Hs. 23349 ESTs 2. 68 449785 A1225235 Hs. 288300 Homo sapiens cDNA : FU23231 fis, clone C 2. 68 446269 AW263155 Hs. 14559 hypothetical protein FU10540 2. 68 443349 A1052572 Hs. 269864 ESTs 2. 68 426514 BE616633 Hs. 301122 bone morphogenetic protein 7 (osteogenic 2. 67 417079 U65590 Hs. 81134 inteAeukin 1 receptor antagonist 2. 67 444754 T83911 Hs. 11881 transmembrane 4 superfamily member 4 2. 67 424687 J05070 Hs. 151738 maixmelalloproteinase9 (gelaù'næB 2. 66 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 2. 65 424408 Al754813 Hs. 146428 collagen, type V, alpha 1 2. 65 430832 A1073913 Hs. 100686 ESTs, Weakly similar to secreted cement 2. 65 427217 AA399272 Hs. 144341 ESTs 2. 65 429170 NM 001394 Hs. 2359 dual specificity phosphatase 4 2. 64 450400 A1694722 Hs. 279744 ESTs 2. 64 435380 AA679001 Hs. 192221 ESTs 2. 64 432375 BE536069 Hs. 2962 S100 calcium-binding protein P 2. 63 453700 AB009426 Hs. 560 apolipoprolein B mRNA ediSng enzyme, ca 2. 63 422938 NM_001809 Hs. 1594 centromere protein A (17kD) 2. 63 453134 AA032211 Hs. 118493 ESTs 2. 63 420727 H75701 Hs. 99886 complement component 4-binding protein, 2. 62 408868 AW292286 Hs. 255058 ESTs 2. 62 414972 BE263782 Hs. 77695 KIAA0008 gene product 2. 62 440255 Api932285 Hs. 160569 ESTs 2. 62 403055 2. 62 443247 BE614387 Hs. 47378 ESTs. Moderately similar to hypothetical 2. 62 447400 AK000322 Hs. 18457 hypothetical protein FLJ20315 2. 61 413753 U17760 Hs. 301103 Human DNA sequence from clone 272L16 on 2. 61 445114 AW991959 Hs. 254664 ESTs 2. 61 422397 AJ223366 Hs. 116051 myelomaoverexpressedgene (inasubselo 2. 60 407366 AF026942 gb : Homo sapiens cig33 mRNA, pariia'sequ 2. 60 432009 AL137424 gb : Homo sapiens mRNA ; cDNA DKFZp761 G2123 2. 60 440249 A1246590 Hs. 125325 ESTs 2. 60 433220 A1076192 Hs. 131933 ESTs 2. 60 438533 Api440266 Hs. 170673 ESTs, Weakly similar to AF126780 1 retin 2. 60 436251 BE515065 Hs. 5092 nucleolar prolein (KKE/D repeat) 2. 60 424717 H03754 Hs. 152213 wingless-lype MMTV integration sile fami 2. 60 448988 Y09763 Hs. 22785 gamma-aminobubric æid (GABA) A recepto 2. 60 425463 AK000740 Hs. 157986 hypolheUca'prolein FW20733 2. 60 435370 A1964074 Hs. 225838 ESTs 2. 59 432215 AU076609 Hs. 2934 nbonucleoUdereduclæM1 polypepUde 2. 59 409142 AL136877 Hs. 50758 chromosome-associated polypeptide C 2. 59 443919 A1091284 Hs. 135224 ESTs 2. 58 413268 AL039079 Hs. 75256 eXqulalorofG-proteinsignaling 1 2. 58 404519 2. 58 414998 NM002543 Hs. 77729 oxidised low density lipoprotein (lectin 2. 57 429597 NM003816 Hs. 2442 a disinlegrin and melalloproleinae doma 2. 57 426841 A1052358 Hs. 193726 ESTs 2. 57 416768 AA363733 Hs. 1032 regenerating islet-derived 1 alpha (panc 2. 57 417933 X02308 Hs. 82962 thymidylate synthetase 2. 56 433675 AW977653 Hs. 110771 Homo sapiens cDNA : FU21904 fis, clone H 2. 56 441384 AA447849 Hs. 288660 protease, serine. 23 2. 56 451939 U80456 Hs. 27311 single-minded (Drosophila) homolog 2 2. 56 418867 D31771 Hs. 89404 msh (Drosophila) homeo box homolog 2 2. 55 449042 AW294985 Hs. 301148 potassium voltage-gated channel, lsk-rel 2. 55 416065 BE267931 Hs. 78996 proliferating ceHnuclear antigen 2. 55 414132 Api801235 Hs. 48480 ESTs 2. 55

431890 X17033 Hs. 271986 integrin, alpha 2 (CD49B, alpha 2 subuni 2. 55 407830 NM_001086 Hs. 587 arylacetamide deacetylase (esterase) 2. 55 434815 AF155582 Hs. 46744 corel UDP-galactose : N-acetylgalactosamin 2. 54 415250 F02614 Hs. 27319 ESTs 2. 54 435647 A1653240 Hs. 49823 ESTs 2. 54 459306 AW578452 Hs. 232988 ESTs, Weakly similar to mucin [H. sapiens 2. 54 414361 A1086138 Hs. 204044 ESTs 2. 54 425782 U66468 Hs. 159525 ll growrth negulatory wiih EF-hand doma 2. 53 416984 H38765 Hs. 80706 diaphorase (NADH/NADPH) (cytochrome b-5 2. 53 431183 NM 006855 Hs. 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic retic 2. 53 436043 AW963838 Hs. 168830 Homo sapiens cDNA FW12136 hs, clone MA 2. 53 456743 A1630124 Hs. 7434 ESTs 2. 53 410268 AA316181 Hs. 61635 six transmembrane epithelial antigen of 2. 52 424905 NM2497 Hs. 153704 NIMA (never in mitosis gene a)-related k 2. 52 411734 AW374954 Hs. 71779 Homo sapiens DNA from chromosome 19. cos 2. 52 432657 AA831815 Hs. 270940 ESTs 2. 51 434080 At820719 Hs. 154662 hypothetical protein PR01472 2. 51 438190 AA780020 Hs. 136798 ESTs 2. 51 418969 W33191 Hs. 28907 hypothetical protein FU20258 2. 51 446405 AW451259 Hs. 57851 ESTs 2. 51 450002 Al679524 Hs. 201629 ESTs, Moderately similar to ALU8_HUMAN A 2. 51 431808 M30703 Hs. 270833 amphiregulin (schwannoma-derived growth 2. 51 429093 NM 000253 Hs. 195799 microsomaltrigtyceride transfer protein 2. 50 447634 AW967902 Hs. 5152 HomosapienscDNA : FLJ22618 fis, clone H 2. 50 436393 AW022213 Hs. 143617 ESTs 2. 50 453751 R36762 Hs. 101282 HomosapiensmRNA cDNADKFZp434B102 (fr 2. 49 445669 A1570830 Hs. 174870 ESTs 2. 49 445865 A1262584 Hs. 145575 ESTs 2. 49 448437 AW470125 gb : xw60cO4. xl NCI CGAP Panl Homosapiens 2. 49 414883 AA926960 Hs. 77550 CDC28 protein kinase 1 2. 49 406747 A1925153 Hs. 217493 annexin A2 2. 49 446921 AB012113 Hs. 16530 small inducible cytokine subfamily A (Cy 2. 49 426322 J05068 Hs. 2012 transcobalamin I (vitamin B12 binding pr 2. 48 412903 BE007967 Hs. 155795 ESTs 2. 48 422515 AW500470 Hs. 117950 mullifuncúonalpolypepUdesimilarloS 2. 48 447030 AW444659 Hs. 232184 ESTs 2. 48 448454 NM005879 Hs. 21254 TRAF interacting protein 2. 48 419092 J05581 Hs. 89603 mucin 1, transmembrane 2. 48 406671 AA129547 Hs. 285754 met proto-oncogene (hepatocyte growth fa 2. 48 409640 U78722 Hs. 55481 zinc finger protein 165 2. 48 424639 A1917494 Hs. 131329 ESTs 2. 48 404171 2. 47 414747 U30872 Hs. 77204 centromere protein F (350/400kD, mitosin 2. 47 407839 AA045144 Hs. 161566 ESTs 2. 47 410406 A1969703 Hs. 301842 ESTs 2. 47 452220 BE158006 Hs. 212296 ESTs 2. 46 427691 AW194426 Hs. 20726 ESTs 2. 46 421493 BE300341 Hs. 104925 ectodermal-neural cortex (with BTB-like 2. 46 444838 AV651680 Hs. 208558 ESTs 2. 46 413816 AW958181 Hs. 189998 ESTs 2. 46 408296 AL117452 Hs. 44155 DKFZP586G1517 protein 2. 46 436613 AA972691 Hs. 192974 Homo sapiens cDNA FW12735 hs, clone NT 2. 45 445417 AK001058 Hs. 12680 HomosapienscDNAFW10196hs, cloneHE 2. 45 432874 W94322 Hs. 279651 melanoma inhibitory activity 2. 45 425268 A1807883 Hs. 156932 ESTs 2. 45 425397 J04088 Hs. 156346 topoisomerase (DNA) llalpha (170hD) 2. 45 408308 AL033377 Hs. 44197 hypotheticalprotein DKFZp564D0462 2. 45 427961 AW293165 Hs. 143134 ESTs 2. 45 422363 T55979 Hs. 115474 replication factor C (activator 1) 3 (38 2. 45 433083 AL042759 Hs. 191762 ESTs 2. 45 439848 AW979249 gb : EST391359 MAGE resequences, MAGP Homo 2. 44 431924 AK000850 Hs. 272203 Homo sapiens cDNA FW20343 hs, clone AD 2. 44 431457 NM 012211 Hs. 256297 integrin, alpha11 2. 44 443949 AW827419 Hs. 235070 ESTs 2. 44 416498 U33632 Hs. 79351 potassium channel, subfamily K, member 1 2. 44 428484 AF104032 Hs. 184601 solulecarrierfamily7 (cafonicamino 2. 43 431958 X63629 Hs. 2877 cadherin 3, type 1, P-cadherin (placenta 2. 43 413833 Z15005 Hs. 75573 centromere protein E (312) 2. 43 407243 AA058357 Hs. 74466 carcinoembryonicantigen-retatedcetiad 2. 43 410044 BE566742 Hs. 58169 highly expressed in cancer, rich in leuc 2. 43 424273 W40460 Hs. 144442 phospholipase A2, group X 2. 42 409533 AW969543 Hs. 21291 mitogen-activated protein kinase kinase 2. 42 453966 BE148734 Hs. 252833 ESTs 2. 42 427043 AA397679 Hs. 298460 ESTs 2. 42 419741 NM 007019 Hs. 93002 ubiquitin carrier protein E2-C 2. 42 449987 AW079749 Hs. 184719 ESTs, WeahlysimilarloAF116721 112PR0 2. 42 433159 AB035898 Hs. 150587 kinesin-like prolein 2 2. 42 439396 BE562958 Hs. 74346 ESTs, Weakly similar to/prediction 2. 42 426427 M86699 Hs. 169840 TTK protein kinase 2. 41 434725 AK000796 Hs. 4104 hypothetical protein 2. 41 427719 A1393t22 Hs. 134726 ESTs 2. 41 433312 Ai241331 Hs. 131765 ESTs 2. 41 432615 AA557191 Hs. 55028 ESTs 2. 41

407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 2. 41 419220 AA811938 Hs. 291759 ESTs 2. 40 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) 2. 40 435219 AA676349 Hs. 190331 ESTs 2. 40 447164 AF026941 Hs. 17518 HomosapienscigSmRNA, patiasequence 2. 40 416713 T70174 gb : ycl8b03. sl Stratagenelung (937210) H 2. 40 418322 AA284166 Hs. 84113 cyclin-dependent kinase inhibitor 3 (CDK 2. 40 409902 A1337658 Hs. 156351 ESTs 2. 40 443597 A1078418 gb : ozO5eO3. xl Soares_feta_liver_spleen_ 2. 40 404253 2. 40 428970 BE276891 Hs. 194691 reunoic acid induced 3 2. 40 443462 A1064690 Hs. 171176 ESTs 2. 39 418693 Api750878 Hs. 87409 thrombospondin 1 2. 39 451237 AW600293 gb : EST00049pGEM-TlibrayHomosapiens 2. 39 407756 AA116021 Hs. 38260 ubiquitin specific protease 18 2. 39 437935 AW939591 Hs. 5940 hypothetical protein Fou20063 2. 39 445625 BE246743 Hs. 288529 Homo sapiens cDNA : FLJ22635 fis, clone H 2. 39 435937 AA830893 Hs. 119769 ESTs 2. 39 438993 AA828995 gb : od77bO8. s1 NCl_CGAP_Ov2 Homo sapiens 2. 38 422082 AA016188 Hs. 111244 hypothetical protein 2. 38 435849 BE305242 Hs. 112442 ESTs, WeahlysimilartoCLDE_HUMANCLAUD 2. 38 407242 M18728 gb : Human nonspecific crossreacting antig 2. 38 450396 AU077002 Hs. 24950 regulator of G-protein signalling 5 2. 38 430354 AA954810 Hs. 239784 human homolog of Drosophila ScribWe 2. 38 422578 AF239666 Hs. 1545 caudal type homeo box transcription fact 2. 38 446342 BE298665 Hs. 14846 Homo sapiens mRNA ; cDNA DKFZp564D016 (fr 2. 38 450737 AW007152 Hs. 203330 ESTs 2. 38 428070 T63918 Hs. 182313 retinol-binding protein 2, cellular 2. 38 416111 AA033813 Hs. 79018 chnomaúnasemblyfætor1, subunitA (2, 37 433345 A1681545 Hs. 152982 HomosapienscDNAFU13117fis. c) oneNT 2. 37 427557 NM 002659 Hs. 179657 plasminogen ac5vator, urokinase recepto 2. 37 423554 M90516 Hs. 1674 glutamine-fructose-6-phosphate transamin 2. 37 453204 R10799 Hs. 191990 ESTs 2. 37 453876 AW021748 Hs. 110406 ESTs 2. 36 425081 X74794 Hs. 154443 minichromosome maintenance deficient (S. 2. 36 434682 AA827165 Hs. 191958 ESTs 2. 36 439737 Al751438 Hs. 41271 Homo sapiens mRNA full length inser cDN 2. 36 414108 A1267592 Hs. 75761 SFRS protein kinase 1 2. 36 417900 BE250127 Hs. 82906 CDC20 (cell division cycle 20, S. cerevi 2. 36 428046 AW812795 Hs. 155381 ESTs, Moderately similar to 138022 hypot 2. 36 448826 A1580252 Hs. 293246 ESTs, Weakly similar to putative p150 [H 2. 36 441020 W79283 Hs. 35962 ESTs 2. 36 448019 AW947164 Hs. 195641 ESTs 2. 36 431753 X76029 Hs. 2841 neuromedin U 2. 36 441703 AW390054 Hs. 192843 ESTs 2. 36 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-Z36 418526 BE019020 Hs. 85838 solutecarierfamily16 (monocarboxylic 2. 36 444478 W07318 Hs. 240 M-phase phosphoprotein 1 2. 36 421878 AA299652 Hs. 111496 Homo sapiens cDNA FLJ11643 fis, clone HE 2. 35 428388 AA729827 Hs. 101265 Homo sapiens cDNA : FLJ22593 fis, clone H 2. 35 436961 AW375974 Hs. 156704 ESTs 2. 35 408194 AA601038 Hs. 191797 ESTs 2. 35 438578 AA811244 Hs. 164168 ESTs 2. 35 429183 A8014604 Hs. 197955 KIAA0704 protein 2. 35 435663 A1023707 Hs. 134273 ESTs 2. 35 430290 A1734110 Hs. 136355 ESTs 2. 34 423441 R68649 Hs. 278359 absent in melanoma 1 like 2. 34 453900 AW003582 Hs. 226414 ESTs, Weakly similar to ALU8_HUMAN ALU S 2. 33 450378 AW249181 Hs. 19954 ESTs, WeaklysimilartocDNAESTyk386e1 2. 33 432877 AW974111 Hs. 292477 ESTs 2. 33 451928 A1823801 Hs. 30315 ESTs 2. 33 426227 U67058 Hs. 168102 Human proteinase activated receptor-2 mR 2. 33 418245 AA088767 Hs. 83883 transmembrane, prostate androgen induced 2. 33 415083 A1632683 Hs. 27179 HomosapienscDNAFLJlZ933hs, cloneNT 2. 33 435106 AA100847 Hs. 193380 ESTs, Highly similar to AF1746001 F-box 2. 33 432193 AA372264 Hs. 273193 hypothetical protein FLJ10706 2. 33 458531 AA367718 Hs. 159083 ESTs 2. 33 449532 W74653 Hs. 271593 ESTs 2. 33 446354 AW449650 Hs. 202249 ESTs 2. 33 409703 NM006187 Hs. 56009 Z-Soligoadenylate synthetase 3 2. 33 419373 NM 003244 Hs. 90077 TG-interacting factor (TALE family homeo 2. 32 435607 W73428 Hs. 8750 uncharacterized bone marrow protein BM04 2. 32 405818 2. 32 423132 AF070647 Hs. 124126 Homo sapiens clone 24438 mRNA sequence 2. 32 444371 BE540274 Hs. 239 forkhead box M1 Z32 432675 Al791855 Hs. 105884 ESTs 2. 32 411773 NM006799 Hs. 72026 protease, serine, 21 (testisin) 2. 31 448569 BE382657 Hs. 21486 signal transducer and activator of trans 2. 31 434775 AA648983 Hs. 212911 ESTs 2. 31 407378 AA299264 gb : EST11752UlerusHomosapienscDNAS 2. 31 442353 BE379594 Hs. 49136 ESTs 2. 31 422611 AA158177 Hs. 118722 fucosyltransferase8 (alpha (1, 6) fucosy Z31 409965 AA079229 gb : zm95f04. r1 Stratagene colon HT29 (937 2. 31

421677 H64092 Hs. 38282 ESTs 2. 31 419493 AF001212 Hs. 90744 proteasome (prosome, macropain) 26S subu 2. 31 424435 AB011167 Hs. 146957 KIAA0595 protein 2. 30 446880 Api811807 Hs. 108646 Homo sapiens cDNA FLJ 12534 fis, clone NT 2. 30 452795 AW392555 Hs. 18878 hypothetical protein FU21620 2. 30 452834 A1638627 Hs. 105685 ESTs 2. 30 409262 AK000631 Hs. 52256 hypothetical protein FU20624 2. 30 428125 AA393071 Hs. 182579 leucine aminopeptidase 2. 30 417655 AA780791 Hs. 14014 ESTs, Weakly similar to KIAA0973 protein 2. 29 407287 At678812 Hs. 201658 ESTs, Weakly similar to ALU4_HUMAN ALU S 2. 29 428923 BE047698 Hs. 188785 ESTs 2. 29 452203 X57522 Hs. 158164 ATP-binding cassette, sub-family B (MDRI 2. 29 409402 AF208234 Hs. 695 cystatin B (stefin B) 2. 29 419359 AL043202 Hs. 90073 chromosome segregation 1 (yeast homolog) 2. 29 451999 AW176401 Hs. 27424 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2. 29 400811 AF219139 Hs. 87726 KIAA0154 protein ; ADP-ribosylation facto 2. 29 436396 AI683487 Hs. 299112 HomosapienscDNAFW11441hs, chneHE 2. 28 442152 R39246 Hs. 239666 Homo sapiens cDNA FW 13495 hs, done PL 2. 28 420931 AF044197 Hs. 100431 small inducible cytokine B subfamily (Cy 2. 28 410174 AA306007 Hs. 59461 DKFZP434C245 protein 2. 28 425247 NM_005940 Hs. 155324 mabix metadloproteinase 11 (strornelysin 2. 28 438170 A1916685 Hs. 194601 ESTs 2. 28 445378 AV653564 Hs. 226946 ESTs 2. 28 428048 AA705745 Hs. 185070 ESTs 2. 28 414696 AF002020 Hs. 76918 Niemann-Pick disease, type C1 2. 27 444665 BE613126 Hs. 47783 ESTs, WeahlysimilartoT12540hypotheU Z27 427660 Au741320 Hs. 114121 HomosapienscDNA FW23228hs, cloneC 2. 27 422128 AW881145 gb : QVO-OT0033-010400-182-aO7 OT0033 Homo 2. 27 433535 AF111106 Hs. 3382 protein phosphatase 4, regulatory subuni 2. 27 415857 AA866115 Hs. 301646 Homo sapiens CDNA FUI 1381 fis, clone HE 2. 27 421155 H87879 Hs. 102267 lysyl oxidase 2. 27 405545 2. 27 449467 AW205006 Hs. 197042 ESTs 2. 27 445537 AJ245671 Hs. 12844 EGF-like-domain, multiple 6 2. 27 450680 AF131784 Hs. 25318 Homo sapiens clone 25194 mRNA sequence 2. 26 423634 AW959908 Hs. 1690 heparin-binding growth factor binding pr 2. 26 443868 W88483 Hs. 293650 ESTs 2. 26 407742 AF186252 Hs. 38084 sulfotransferase family, cytosolic, 1C, 2. 26 428330 L22524 Hs. 2256 matrix metalbproteinae 7 (matrilysin, 2. 26 432655 AA832195 Hs. 292266 ESTs 2. 26 429731 AK001592 Hs. 212172 beta, beta-carotene 15, 15-dioxygenase ho 2. 26 400514 2. 26 431846 BE019924 Hs. 271580 uroplakin 1B 2. 26 439521 A1808955 Hs. 58248 ESTs 2. 26 426010 AA136563 Hs. 1975 Homo sapiens cDNA : FLJ21007 fis, clone C 2. 26 437641 AA811452 Hs. 291911 ESTs 2. 26 418982 A1348838 Hs. 13073 ESTs 2. 26 411393 AW797437 Hs. 69771 B-factor, properdin 2. 26 414809 A1434699 Hs. 77356 transferrin receptor (p90. CD71) 2. 25 419488 AA316241 Hs. 90691 nucleophosmin/nucleoplamin 3 2. 25 434540 NM016045 Hs. 5184 TH1 drosophilahomolog 2. 25 449962 AA004879 Hs. 187820 ESTs 2. 25 410196 A1936442 Hs. 59838 hypothetica protein FU10808 2. 25 456844 A1264155 Hs. 152981 CDP-diacylglycerol synthase (phosphatida 2. 25 414368 W70171 Hs. 75939 undine monophosphate kinae 2. 25 408353 BE439838 Hs. 44298 hypothetical protein 2. 25 439223 AW238299 Hs. 23945 ESTs 2. 25 448753 AL048858 Hs. 224355 ESTs, Weakly similar to A39650 protein k 2. 25 428479 Y00272 Hs. 184572 cell division cycle 2, G1 to S and G2 to 2. 24 432403 AA550815 Hs. 124840 ESTs 2. 24 424971 AA479005 Hs. 154036 tumor suppressing subtransferable candid 2. 24 432673 AB028859 Hs. 278605 ER-associated DNAJ ; ER-associated Hsp40 2. 24 446887 A1346656 Hs. 156652 Homo sapiens cDNA : Fla22800 fis, clone K 2. 24 452833 BE559681 Hs. 30736 KIAA0124 protein 2. 24 409432 D49372 Hs. 54460 small inducible cytokine subfamily A (Cy 2. 24 422039 BE567832 Hs. 82148 hypothetical protein 2. 24 429925 NM000786 Hs. 226213 cytochrome P450, 51 (lanosterol 14-alpha 2. 24 445413 AA151342 Hs. 12677 CGI-147 protein 2. 23 423645 A1215632 Hs. 147487 ESTs 2. 23 447532 AK000614 Hs. 18791 hypothetical protein FU20607 2. 23 423515 AA327017 Hs. 162204 ESTs 2. 23 444743 AA045648 Hs. 11817 nudix (nucleoside diphosphate linked moi 2. 23 434518 H56995 Hs. 37372 Homo sapiens DNA binding pepbde MRNA, p 2. 23 435602 AF217515 Hs. 283532 uncharacterized bone marrow protein BM03 2. 23 449974 AW970948 Hs. 269403 ESTs 2. 23 424927 AW973666 Hs. 153850 hypothetical protein C321D2. 4 2. 23 457982 AW856093 Hs. 183617 ESTs 2. 23 414420 AA043424 Hs. 76095 immediate early response 3 2. 23 449019 Api949095 Hs. 67776 ESTs, Weakly similar to ALU7 HUMAN ALU S 2. 23 431840 AA534908 Hs. 2860 POU domain, class 5, transcription facto 2. 23 452930 AW195285 Hs. 194097 ESTs 2. 23 436391 AJ227892 Hs. 146274 ESTs 2. 23 439186 Al697274 Hs. 6487 Xq28, 2000bpsequencecontg. ORF 2. 23

427254 AL121523 Hs. 97774 ESTs. 2. 22 424517 A ! 539443 Hs. 137447 Homo sapiens CDNA FU 12169 fis, clone MA 2. 22 414732 AW410976 Hs. 77152 minichromosome maintenance deficient (S. 2. 22 411835 U29343 Hs. 72550 hyaluronan-mediated motility receptor (R 2. 22 427647 W19744 Hs. 180059 Homo sapiens cDNA FLJ20653 fis, clone KA 2. 22 438223 AA781171 gb : aj24dO5. sl Soares_tesUs_NHTHomosap 2. 22 434504 Al887341 Hs. 121590 Homo sapiens cDNA FLJ12827 fis, clone NT 2. 22 450149 AW969781 Hs. 293440 ESTs, Moderately similar to ZIC2 protein 2. 22 439211 Api890347 Hs. 271923 Homo sapiens cDNA : FLJ22785 fis, clone K 2. 22 401519 2. 22 441794 AW197794 Hs. 253338 ESTs 2. 22 412108 AA100293 Hs. 185043 ESTs 2. 22 431849 Api670823 Hs. 85573 Homo sapiens mRNA ; cDNA DKFZp566N034 (fr 2. 22 444969 Al203334 Hs. 160628 ESTs 2. 21 408901 AK001330 Hs. 48855 hypothetical protein FU10468 2. 21 434423 NM 006769 Hs. 3844 LIM domain only 4 2. 21 439328 W07411 Hs. 118212 ESTs, Moderately similar to ALU3 HUMAN A 2. 21 400021 AFFXcontrol : STAT1 2. 21 432140 AK000404 Hs. 272688 hypothetical protein FU20397 2. 21 434170 AA626509 Hs. 122329 ESTs 2. 21 423453 AW450737 Hs. 128791 CGI-09 protein 2. 21 428438 NM 001955 Hs. 2271 endothelin 1 2. 21 433102 A1343966 Hs. 158528 ESTs 2. 21 421470 R27496 Hs. 1378 annexinA3 2. 21 425499 T62489 gb : ycO3fO9. r1 Stratagene lung (937210) H 2. 21 438280 AW015534 Hs. 217493 annexinA2 2. 21 440381 AA917808 Hs. 190495 ESTs 2. 20 453779 N35187 Hs. 43388 ESTs 2. 20 433627 AF078866 Hs. 284296 Homo sapiens cDNA : FLJ22993 fis, clone K 2. 20 417944 AU077196 Hs. 82985 collagen, type V, alpha 2 220 452299 AW206330 Hs. 73239 hypothetical protein FLJ10901 2. 20 422689 AW856665 gb : RC3-CT0297-Z90100-013-dO3 CTOZ97 Homo 2. 20 448457 H65629 Hs. 245997 ESTs 2. 20 416221 BE513171 Hs. 79086 mitochonddal dbosomal protein L3 2. 20 426125 X87241 Hs. 166994 FATtumorsuppressor (Drosophila) homolo 2. 20 430603 AA148164 Hs. 247280 HBV associated factor 2. 20 425274 BE281191 Hs. 155462 minichromosome maintenance deficient (mi 2. 20 452679 Z42387 Hs. 4299 HomosapienscDNA FW20965hs, cloneA 2. 20 410619 BE512730 Hs. 65114 keratin 18 2. 20 424332 AA338919 Hs. 101615 ESTs 2. 20 442490 AW965078 Hs. 30212 thyroid receptor interacting protein 15 2. 20 418661 NM001949 Hs. 1189 HumanmRNAforKIM0075gene, partialcd 2. 20 419341 N71463 Hs. 118888 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 20 427920 Z11502 Hs. 181107 annexinA13 2. 19 413879 AA132961 Hs. 212533 Homo sapiens cDNA : FLJ22572 fis, clone H 2. 19 419752 AA249573 Hs. 152618 ESTs 2. 19 441436 AW137772 Hs. 185980 ESTs 2. 19 413095 AA494359 Hs. 30715 ESTs 2. 19 403208 2. 19 422596 AF063611 Hs. 118633 Z-Soligoadenylatesynthetae-like 2. 19 444261 AA298958 Hs. 10724 MDS023 protein 2. 19 419474 AW968619 Hs. 155849 ESTs 2. 19 453883 Api638516 Hs. 77448 aldehyde dehydrogenase 4 (glutamate gamm 2. 18 423401 NM001992 Hs. 128087 coagulation factor t) (thrombin) recepto 2. 18 453450 AW797627 Hs. 89474 ADP-nbosylationfætor6 2. 18 440250 AA876179 Hs. 134650 ESTs 2. 18 444334 BE296785 Hs. 10848 KIAA0187 gene product 2. 18 437616 A1797163 Hs. 207954 ESTs 2. 18 451807 W52854 Hs. 27099 DKFZP564J0863 protein 2. 18 430441 BE398091 Hs. 6880 DKFZP434D156 protein 2. 18 414602 AW630088 Hs. 76550 Homo sapiens mRNA ; cDNADKFZp564B1264 (f 2. 18 411678 A1907114 Hs. 71465 squalene epoxidase 2. 18 453735 A1066629 Hs. 125073 ESTs 2. 18 450499 AA235207 Hs. 250456 hypothetical protein DKFZp762F2011 2. 18 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7. S. cerevisi 2. 18 421532 AW138207 Hs. 146170 hypothetical protein FU22969 2. 18 444342 NM_014398 Hs. 10887 similar to lysosome-associated membrane 2. 18 451099 R52795 Hs. 25954 interteukin 13 receptor. a ! pha 2 2. 18 444207 AI565004 Hs. 79572 cathepsin D (Iysosoma apabl proteae Z18 425873 NM_013390 Hs. 160417 transmembrane protein 2 2. 17 417404 NM_007350 Hs. 82101 pleckstrin homology-like domain, family 2. 17 449437 AI702038 Hs. 100057 Homo sapiens cDNA : FLJ22902 fis, clone K 2. 17 446995 Ai355012 gb : qul6dlO. xl NCI_CGAP-Ov23 Homo sapiens 2. 17 431548 Api834273 Hs. 9711 Homo sapiens cDNA FLJ 13018 fis, clone NT 2. 17 411127 AA668995 Hs. 218329 hypothetical protein 2. 17 439961 AA857451 Hs. 269696 ESTs 2. 17 429125 AA446854 Hs. 271004 ESTs 2. 17 407103 AA424881 Hs. 256301 ESTs 2. 17 435990 Al015862 Hs. 131793 ESTs Z17 415116 AA160363 Hs. 269956 ESTs 2. 17 440052 A1633744 Hs. 195648 ESTs 2. 17 423961 D13666 Hs. 136348 osteoblast specific factor 2 (fasciclin 2. 17 431070 AW408164 Hs. 249184 transcription factor 19 (SC1) 2. 16

443599 A1079559 Hs. 134125 ESTs 2. 16 423623 AB011117 Hs. 129943 KIAA0545 protein 2. 16 427258 AA400091 Hs. 39421 ESTs 2. 16 418113 A1272141 Hs. 83484 SRY (sex determining region Y)-box 4 2. 16 450835 BE262773 Hs. 25584 hypothetical protein FLJ10767 2. 16 428698 AA852773 Hs. 297939 ESTs, Weakly similar to T17344 hypotheti 2. 16 421408 A1688223 Hs. 104114 H. sapiens HCG I MRNA 2. 16 449057 AB037784 Hs. 22941 KIAA1363 protein 2. 16 408947 AL080093 Hs. 49117 HomosapiensmRNA ; cDNADKFZp564N1662 (f 2. 16 443552 N65982 Hs. 109434 ESTs 2. 16 448153 Y10805 Hs. 20521 HMT1 (hnRNP methyltransferase, S. cerevi 2. 16 424653 AW977534 Hs. 151469 caicium/catmoduiin-dependentserineprot 2. 16 431341 AA307211 Hs. 251531 proteasome (prosome, macropain) subunit, 2. 16 452865 Al924046 Hs. 119567 ESTs 2. 16 432789 D26361 Hs. 3104 KIAA0042 gene product 2. 16 438580 AA811262 Hs. 299202 ESTs 2. 16 422192 AA305159 Hs. 113019 fis485 Z15 425607 U09860 Hs. 158333 protease, serine, 7 (enterokinase) 2. 15 447289 AW247017 Hs. 36978 melanoma antigen, family A. 3 2. 15 447674 BE270640 Hs. 19192 cyclin-dependentkinae2 2. 15 441021 AW578716 Hs. 7644 Hlhistonefamily, member2 2. 15 442432 BE093589 Hs. 38178 Homo sapiens cDNA : FLJ23468 fis, clone H 2. 15 426471 M22440 Hs. 170009 transforming growth factor, alpha 2. 15 431941 AK000106 Hs. 272227 HomosapienscDNAFW20099hs, cbneC0 2. 15 414761 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homolog2 2. 15 447033 A1357412 Hs. 157601 ESTs 2. 15 410407 X66839 Hs. 63287 carbonic anhydrae IX 2. 15 446077 BE251048 Hs. 22579 Homo sapiens clone CDABP0036 mRNA sequen 2. 15 420900 AL045633 Hs. 44269 ESTs 2. 15 411975 Api916058 Hs. 144583 ESTs, Weakly similar to gag (H. saoens) 2. 15 419239 AA468183 Hs. 184598 Homo sapiens cDNA : FLJ23241 fis, clone C 2. 15 449571 AW016812 Hs. 200266 ESTs 2. 15 452721 AJ269529 Hs. 30377 Homo sapiens EST from clone 470080, full 2. 15 410491 AA465131 Hs. 64001 Homosapiensclone25218mRNAsequence 2. 14 410664 NM_006033 Hs. 65370 lipase, endothelial 2. 14 435730 AB020635 Hs. 4984 KIAA0828 protein 2. 14 452835 AK001269 Hs. 30738 hypothetical protein FU10407 2. 14 452092 BE245374 Hs. 27842 hypothefical protein FU 11210 2. 14 401708 2. 14 411400 AA311919 Hs. 69851 GAR1 protein 2. 14 448526 AB028946 Hs. 21361 KIAA1023 protein 2. 14 421175 A1879099 Hs. 102397 GIOT-3forgonadotropininducibletransc 2. 14 412338 AA151527 Hs. 69485 HomosapienscDNAFW12U6hs, cloneNT 2. 14 420894 AA744597 Hs. 88854 ESTs 2. 14 409235 AA188827 Hs. 7988 ESTs, Weakly similar to endo-alpha-0. man 2. 14 412870 N22788 Hs. 82407 HomosapiensHSPC296mRNA, parUalcds 2. 14 447760 Al431328 Hs. 291179 ESTs, Weakly similar to topoisomerase 1 2. 14 413511 AI627178 Hs. 75412 Arginine-rich protein 2. 13 432945 AL043683 Hs. 271357 ESTs, Weakly similar to unnamed protein 2. 13 418592 X99226 Hs. 284153 Fanconi anemia, complementaton group A 2. 13 441790 AW294909 Hs. 132208 ESTs 2. 13 425298 AK000209 Hs. 155556 hypotheGcal protein FU20202 2. 13 450956 AW193531 Hs. 205647 ESTs, ModeratelysimilartoALU1 HUMANA 2. 13 419569 Ai971651 Hs. 91143 jagged 1 (Alagille syndrome) 2. 13 421508 NM 004833 Hs. 105115 absent in melanoma 2 2. 13 453975 AW009808 Hs. 270829 ESTs 2. 13 413670 AB000115 Hs. 75470 hypothetical protein, expressed in osteo 2. 13 422783 AA598956 Hs. 120439 ethanolamine kinase 2. 13 444542 Api161293 Hs. 146862 ESTs, Weakly similar to KIAA0525 protein 2. 13 410418 D31382 Hs. 63325 transmembrane proteae, senne 4 2. 13 419791 A1579909 Hs. 105104 ESTs 2. 13 414860 BE255593 Hs. 77502 methionine adenosyttransferase i1, alpha 2. 13 425860 L29339 Hs. 1964 solutecarierfamily5 (sodium/glucose 2. 13 414839 X63692 Hs. 77462 DNA (cytosine-5-)-methyltransferase 1 2. 13 437050 AA766420 Hs. 291606 ESTs 2. 13 430217 N47863 Hs. 180450 ribosomal protein S24 2. 13 420923 AF097021 Hs. 273321 differential expressed in hematopoieti 2. 12 409012 AL117435 Hs. 49725 DKFZP4341216 protein 2. 12 450645 AL117441 Hs. 25264 DKFZP434N126 protein 2. 12 431322 AW970622 gb : EST382704 MAGE resequences, MAGK Homo 2. 12 451356 AA748418 Hs. 164577 ESTs 2. 12 429534 AW976987 Hs. 163327 ESTs 2. 12 428365 M295331 Hs. 183861 Homo sapiens cDNA FU20042 fis, clone CO 2. 12 441495 AW294603 Hs. 127039 ESTs 2. 12 443564 A1921685 Hs. 199713 ESTs 2. 12 410839 NM 006849 Hs. 66581 protein disulfide isomerase 2. 12 433640 AW390125 Hs. 240443 Homo sapiens cDNA : FLJ23538 fis, clone L 2. 12 442947 R40800 Hs. 21303 ESTs 2. 12 414987 AA524394 Hs. 165544 ESTs 2. 12 450510 AA010056 Hs. 242998 ESTs 2. 12 427475 AA403151 Hs. 191605 ESTs 2. 12 444670 H58373 Hs. 37494 ESTs 2. 12 452099 BE612992 Hs. 27931 hypothetical protein FLJ10607 similar to 2. 12

433748 R12244 gb : yf33c12. r1Scaresfetalliverspleen 2. 12 415138 C18356 Hs. 78045 fissue factor pathway inhibitor 2 2. 11 438138 R98299 Hs. 177502 ESTs 2. 11 414788 X78342 Hs. 77313 cyclin-dependent kinase (CDC2-like) 10 2. 11 415474 NM 014252 Hs. 78457 solutecanierfamily25 (mitochondrial 2. 11 416472 AA180756 Hs. 193094 ESTs, ModeratelysimilarhALU4_HUMANA 2. 11 412490 AW803564 Hs. 288850 HomosapienscDNA : FW22528 fis, clone H 2. 11 410718 A1920783 Hs. 191435 ESTs 2. 11 425811 AL039104 Hs. 159557 karyopherinalpha2 (RAGcohortl, impor Z11 433344 AI741506 Hs. 186753 ESTs, Weakly similar to ALU 1 HUMAN ALU S 2. 11 447197 R36075 gb : yh88b01. s1 Soares placenta Nb2HP Homo 2. 11 431621 AW292329 Hs. 163481 ESTs 2. 11 418522 AA605038 Hs. 7149 HomosapienscDNA : FLJ21950 fis, clone H 2. 11 433849 BE465884 Hs. 280728 ESTs 2. 11 438038 AI732629 Hs. 194161 ESTs, Weakly similar to TA2R HUMAN, BETA 2. 11 422032 AA476966 Hs. 110857 polymerase (RNA) in (DNA directed) poly 2. 11 409717 AW452871 Hs. 56043 CGI-115 protein 2. 11 410566 AA373210 Hs. 43047 Homo sapiens CDNA FU 13585 fis, clone PL 2. 11 445837 A1261700 Hs. 145544 ESTs 2. 11 414334 AA824298 Hs. 21331 hypothetical protein FLJ 10036 2. 11 436326 BE085236 Hs. 181244 major histocompatbility complex, class 2. 10 423880 BE278111 Hs. 134200 DKFZP564C186protein 2. 10 421574 AJ000152 Hs. 105924 defensin, beta2 2. 10 437103 AW139408 Hs. 152940 ESTs 2. 10 435550 Api224456 Hs. 4934 H. sapiens polyAsite DNA 2. 10 450747 A1064821 Hs. 48306 ESTs, HighlysimilartoEWS_HUMANRNA-BI 2. 10 437033 AW248364 Hs. 5409 RNA polymerase I subunit 2. 10 417640 D30857 Hs. 82353 protein C receptor, endothelial (EPCR) 2. 10 431120 AA492588 gb : ng99c08. sl NCI CGAP_Thy1 Homo sapiens 2. 10 430510 AW162916 Hs. 241576 hypothetical protein PR02577 2. 10 429669 BE185499 Hs. 2471 KtAA0020 gene product 2. 10 407881 AW072003 Hs. 40968 heparan sulfate (glucosamine) 3-0-sulfot 2. 10 436124 AA705012 Hs. 269584 ESTs 2. 10 436415 BE265254 Hs. 5181 proliferaGon-associated 2G4, 38kD 2. 10 451121 AW973795 Hs. 128927 Homo sapiens cDNA FW 13903 fis, clone TH 2. 10 453968 AA847843 Hs. 62711 ESTs 2. 10 437549 AA759149 gb : ah70eO3. s1Soares_tesús_NHTHomosap 2. 10 407887 AA579668 Hs. 41072 serine (orcysteine) proteinase inhibito 2. 10 447720 AL038765 Hs. 161304 ESTs 2. 09 434769 AA648884 Hs. 134278 Homo sapiens cDNA FW12676 hs, clone NT 2. 09 429743 AA804398 Hs. 288995 hypothetical protein FLJ20813 2. 09 447815 A1432199 Hs. 247084 ESTs 2. 09 441675 A1914329 Hs. 5461 ESTs 2. 09 434274 AA628539 Hs. 116252 ESTs, Moderately similar to ALU1HUMAN A 2. 09 411571 AA122393 Hs. 70811 hypothetical protein Fla20516 2. 09 442525 AF150282 Hs. 145945 ESTs 2. 09 423750 AF165883 Hs. 132415 prefoldin 2 2. 09 449199 Al990122 Hs, 196988 ESTs 2. 09 415363 A1670947 Hs. 78406 phosphatidylinositol-4-phosphate 5-kinas 2. 09 432543 AA552690 Hs. 152423 Homo sapiens cDNA : FU21274 fis, clone C 2. 09 418462 BE001596 Hs. 85266 integrin, beta 4 2. 09 432093 H28383 gb : yl52cO3. rl Scares breast 3NbHBst Homo 2. 09 407862 BE548267 Hs. 50724 Homo sapiens c DNA FLJ 10934 fis, clone OV 2. 09 434442 AA737415 Hs. 152826 ESTs 2. 09 442671 A1005668 Hs. 134779 EST 2. 09 428771 AB028992 Hs. 193143 KIAA1069 protein 2. 09 430335 D80007 Hs. 239499 KIAA0185 protein 2. 08 425087 R62424 Hs. 126059 ESTs 2. 08 412530 AA766268 Hs. 266273 Homo sapiens cDNA FLJ13346 fis, clone OV 2. 08 443450 N66045 Hs. 133529 ESTs 2. 08 418753 BE217818 Hs. 87016 HomosapienscDNA : FLJ22938 fis, clone K 2. 08 432204 Api916132 Hs. 121593 Homo sapiens CONA FU 13123 fis, clone NT 2. 08 439018 AW300887 Hs. 26638 ESTs, Weakly similar to unnamed protein 2. 08 418300 Al433074 Hs. 86682 Homo sapiens cDNA : FU21578 fis, clone C 2. 08 431628 AF146277 Hs. 265561 CD2-associated protein 2. 08 446528 AU076640 Hs. 15243 nucleolar protein 1 (120kD) 2. 08 432284 AA532807 Hs. 105822 ESTs 2. 08 411372 A1147861 Hs. 213289 low density lipoprotein receptor (famili 2. 08 459319 NM 000059 gb : Homo sapiens breast cancer 2, eartyo 2. 08 408730 AV660717 Hs. 47144 DKFZP586N0819 protein 2. 08 443607 A1452512 Hs. 134069 ESTs 2. 08 422058 AA862231 gb : oe13g03. s1NCLCGAP. Ov2 Homo sapiens 2. 08 409220 BE243323 Hs. 51233 tumor necrosis factor receptor superfami 2. 08 429504 X99133 Hs. 204238 lipocalin 2 (oncogene 24p3) 2. 08 409686 AK000002 Hs. 55879 Homo sapiens mRNA for FLJ00036 protein, 2. 08 438394 BE379623 Hs. 27693 CGI-124 protein 2. 08 413092 AA126856 Hs. 118665 ESTs 2. 08 413715 AW851121 Hs. 75497 HomosapienscDNA : FLJ22139 fis, clone H 2. 08 423020 AA383092 Hs. 1608 replication protein A3 (14kD) 2. 07 438378 AW970529 Hs. 86434 Homo sapiens cDNA : FU21816 fis, clone H 2. 07 453379 AA035261 Hs. 61753 ESTs 2. 07 432125 AW972667 Hs. 287510 Homo sapiens cDNA FLJ12300 fis, clone MA 2. 07 449370 AK002114 Hs. 23495 hypothetical protein FUI 1252 2. 07

449318 AW236021 Hs. 108788 ESTs. Weakly similar to zeste ID. melanog 2. 07 450096 AI682088 Hs. 223368 ESTs 2. 07 454011 M31008 Hs. 37009 alkaline phosphatase, intestinal 2. 07 427876 Api494291 Hs. 111977 ESTs 2. 07 422901 R81936 Hs. 121576 aspartate beta-hydroxylase 2. 07 419235 AW470411 Hs. 288433 neurotrimin 2. 07 449207 AL044222 Hs. 23255 nucleoponn 155kD 2. 07 408243 Y00787 Hs. 624 interleukin 8 2. 07 415652 T79213 Hs. 272073 ESTs 2. 07 446546 BE167687 Hs. 156628 ESTs 2. 07 411765 H43346 gb : ypO9aO4. r1 Soares breast 3NbHBst Homo 2. 07 423472 AF041260 Hs. 129057 breast carcinoma amplified sequence 1 2. 07 436211 AK001581 Hs. 80961 polymerase (DNA directed), gamma 2. 07 456157 AW979153 gb : EST391263 MAGE resequences, MAGP Homo 2. 06 407143 C14076 Hs. 248968 EST 2. 06 454269 Api961060 Hs. 296411 ESTs, Moderately similar to KFIKHUMAN K 2. 06 432440 X63597 Hs. 2996 sucrase-isomaltase 2. 06 410668 BE379794 Hs. 65403 hypothetical protein 2. 06 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur 2. 06 450434 AA166950 Hs. 18645 ESTs, Weakly similar to partial CDS [C. e 2. 06 439832 T81829 Hs. 14870 ESTs 2. 06 456264 AW974175 Hs. 105251 ESTs 2. 06 431201 AA678405 Hs. 8854 Human transcription unit PVT gene, exons 2. 06 445021 AK002025 Hs. 12251 Homo sapiens cDNA FLJ11163 fis, clone PL 2. 06 438714 AA814859 Hs. 294112 ESTs 2. 06 445318 AW500652 Hs. 200885 ESTs 2. 06 439951 A1347067 Hs. 124636 ESTs 2. 06 433681 A1004377 Hs. 200360 Homo sapiens CDNA FU 13027 fis, clone NT 2. 06 428307 W27393 Hs. 183648 protein tyrosine phosphatase, receptor t 2. 06 426874 N67325 Hs. 247132 ESTs 2. 06 451295 A1557212 Hs. 17132 ESTs 2. 06 432584 AA928829 Hs. 47099 Homo sapiens cDNA : FU21212 fis, clone C 2. 06 433027 AF191018 Hs. 279923 putative nucleotide binding protein, est 2. 06 433716 AA608808 Hs. 225118 ESTs 2. 06 429412 NM 006235 Hs. 2407 POU domain, dass 2. associating factof 2. 06 426235 A1631964 Hs. 34447 ESTs 2. 06 449026 BE500946 Hs. 209105 ESTs 2. 06 437016 AU076916 Hs. 5398 guanine monphosphate synthetae 2. 06 400019 AFFX control : STAT1 2. 06 408873 AL046017 Hs. 23247 ESTs 2. 06 442547 AA306997 Hs. 268362 ESTs, Weakly similar to hypothetical pro 2. 06 455778 BE088746 gb : CM2-BT0693-210300-123-d09BT0693Homo 2. 06 439975 AW328081 Hs. 6817 Homo sapiens putative oncogene protein m 2. 06 433037 Nu-014158 Hs. 279938 HSPC067 protein 2. 06 440086 NM005402 Hs. 288757 v-ral simian leukemia viral oncogene hom 2. 06 436414 BE264633 Hs. 143638 WD repeat domain 4 2. 05 411770 NM014278 Hs. 71992 heatshockprotein (hsp110/amily) 2. 05 407293 AA602234 Hs. 270551 ESTs, Weakly similar to ALU1HUMANALUS 2. 05 409459 D86407 Hs. 54481 low density lipoprotein receptor-related 2. 05 436238 AK002163 Hs. 301724 ESTs, Highly similar to unnamed protein 2. 05 400517 AF242388 Hs. 149585 lengsin 2. 05 439943 AW083789 Hs. 124620 ESTs 2. 05 421904 BE143533 Hs. 109309 hypothetical protein FLJ20035 2. 05 417850 AA215724 Hs. 82741 primase, polypepUde 1 (49kD) 2. 05 417491 AW376842 Hs. 1085 guanylate cyclase 2C (heat stable entero 2. 05 453775 Nom-002916 Hs. 35120 replication factor C (activator 1) 4 (37 2. 05 435525 A1831297 Hs. 123310 ESTs 2. 05 412627 BE391959 Hs. 74276 chlorideintracellularchannel 1 2. 05 439702 AW085525 Hs. 134182 ESTs 2. 05 440006 AK000517 Hs. 6844 hypothetical protein FU20510 2. 05 432979 AA573263 Hs. 120860 ESTs 2. 05 417308 H60720 Hs. 81892 KIAA0101 gene product 2. 05 432925 AA878324 Hs. 192734 ESTs 2. 05 446311 AW007294 Hs. 149795 ESTs, Weakly similar to ALU 1-HUMAN ALU S 2. 05 427871 AW992405 Hs. 59622 ESTs. Weakly similar to unknown [H. sapie 2. 05 453804 AA300204 Hs. 35276 KIAA0852 protein 2. 05 449939 T86420 Hs. 272139 ESTs 2. 05 455666 BE065813 gb : RC2-BT0318-110100-012-aO8BT0318Homo 2. 05 417819 Al253112 Hs. 133540 ESTs 2. 04 427747 AW411425 Hs. 180655 serine/threoninekinase12 2. 04 415009 C75253 Hs. 220950 ESTs 2. 04 437829 A1358522 Hs. 270188 ESTs 2. 04 435381 AW136397 Hs. 247572 ESTs 2. 04 439778 AL109729 Hs. 18948 ESTs, Highly similar to HPS1-HUMAN PROTE 2. 04 428753 AW939252 Hs. 192927 hypothetical protein FU20251 2. 04 446475 Al908188 Hs. 209245 ESTs 2. 04 431394 AK000692 Hs. 252351 HERV-H LTR-associating 2 2. 04 423701 AA329856 Hs. 143022 ESTs 2. 04 430680 AW138724 Hs. 168974 ESTs, Highly similar to ALU7_HUMAN ALU S 2. 04 422369 AF005216 Hs. 115541 Janus kinase 2 (a protein tyrosine kinas 2. 04 432481 AW451645 Hs. 151504 HomosapienscDNAFW11973hs, cloneHE 2. 04 443746 AW861379 Hs. 160602 ESTs 2. 04 400792 AA635062 Hs. 50094 Homo sapiens mRNA ; cDNA DKFZp43400515 (f 2. 04

432393 AW205863 Hs. 133988 ESTs. Weakly similar to 152825 gene MAC2 2. 04 430785 Z30201 gb : HHEA22G Atrium cDNA library Human hea 2. 04 428343 AL043021 Hs. 12705 ESTs, Weakly similar to plakophilin 2b 2. 04 419329 AY007220 Hs288998 S100. type calcium binding protein A14 2. 04 452488 N74921 Hs. 184389 ESTs 2. 04 403485 2. 04 413313 NM2047 Hs. 75280 glycyl-tRNAsynthetase 2. 04 407634 AW016569 Hs. 301280 ESTs. HighlysimilartoAF241831 lintra 2. 04 433326 Al379486 Hs. 159430 ESTs 2. 03 451129 BE072881 gb : RC2-BT0548-200300-012eO9 BT0548 Homo 2. 03 429165 AW009886 Hs. 118258 prostate cancer associated protein 1 2. 03 422963 M79141 Hs. 13234 ESTs 2. 03 418684 U82987 Hs. 87246 Bcl-2 binding component 3 2. 03 407824 AA147884 Hs. 9812 ESTs 2. 03 434551 BE387162 Hs. 280858 ESTs, Highly similar to XPB_HUMAN DNA-RE 2. 03 440246 W52010 Hs. 191379 ESTs 2. 03 444006 BE395085 Hs. 10086 type I transmembrane protein Fnl4 2. 03 431301 Axa502384 Hs. 151529 ESTs 2. 03 452705 H49805 Hs. 246005 ESTs 2. 03 421724 AB037832 Hs. 107287 KIAA1411 protein 2. 03 420637 AW976153 gb : EST388262 MAGE resequences, MAGN Homo 2. 03 450200 AW975625 Hs. 173088 ESTs 2. 03 447474 AW614220 Hs. 189402 ESTs 2. 03 418852 BE537037 Hs. 273294 hypotheticalprotein FU20069 2. 03 445019 A1205540 Hs. 281295 ESTs 2. 03 435202 A1971313 Hs. 170204 KIAA0551 protein 2. 03 431842 Nom005764 Hs. 271473 epithelial protein up-regulated in carci 2. 03 436198 AK001125 Hs. 300922 Homo sapiens cDNA FU10263 fis, clone HE 2. 03 440773 AA352702 Hs. 37747 hypotheúcal protein FW12484 2. 03 443425 A1056776 Hs. 133397 ESTs 2. 03 454166 AW993356 Hs. 2055 ubiquitin-activating enzyme E1 (A1S9T an 2. 03 407975 X89426 Hs. 41716 endotheli2l cell-specific molecule1 (NO 2. 03 428299 AL038004 Hs. 29419 ESTs 2. 03 418735 N48769 Hs. 44609 ESTs 2. 03 442053 R35343 Hs. 24968 Human DNA sequence from clone RP1-233G16 2. 03 415757 AA830854 Hs. 187810 ESTs. 2. 03 432559 AW452948 Hs. 257631 ESTs 2. 03 425912 AL137629 Hs. 162189 serinelthreoninekinaewithDbl-andpi 2. 02 419395 BE268326 Hs. 90280 5-aminoimidazole-4-carboxamide ribonucle 2. 02 417576 AA339449 Hs. 82285 phosphoribosyigtycinamideformyitransfer 2. 02 418559 AA225048 Hs. 104207 ESTs 2. 02 410855 X97795 Hs. 66718 RAD54 (S. cerevisiae)-like 2. 02 433906 A1167816 Hs. 43355 ESTs 2. 02 422072 AB018255 Hs. 111138 KlAA0712 gene product 2. 02 419546 AA244199 gb : ncO6cO5. s1 NCI_CGAP_Pr1 Homo sapiens 2. 02 446229 A1744964 Hs. 14449 KIAA1609 protein 2. 02 450516 AA902656 Hs. 21943 NIF3 (Ngg1 interacting factor 3, S. pombe 2. 02 431721 AB032996 Hs. 268044 KIAA1170 protein 2. 02 419807 R77402 gb : yi75f1 1. s1 Soares plæenta Nb2HP Homo 2. 02 438192 A1859065 Hs. 16808 ESTs, Weakly similar to paraplegin-like 2. 02 401866 2. 02 443129 R16075 Hs. 21668 ESTs 2. 02 426991 AK001536 Hs. 285803 Homo sapiens cDNA FLJ12852 fis, clone NT 2. 01 414731 Api890434 Hs. 77135 Homo sapiens mRNA ; cDNA DKFZp586A191 (fr 2. 01 424783 AA913909 Hs. 153088 TATA box binding protein (TBP)-associate 2. 01 413293 AL047483 Hs. 75270 GTP-binding protein homologous to Saccha 2. 01 435787 AW162767 Hs. 100914 hypothetical protein FLJ10352 2. 01 422599 BE387202 Hs. 118633 non-metataúccells1, protein (NM23A) 2. 01 442660 AW138174 Hs. 130651 ESTs 2. 01 456553 AA721325 Hs. 189058 ESTs, Weakly similar to cAMP-regulated 9 2. 01 431630 NM2204 Hs. 265829 integrin, alpha 3 (antigen CD49C, alpha 2. 01 431300 AA502346 gb : ne26b03. sl NCI_CGAP Homo sapiens 2. 01 443180 R15875 Hs. 70945 ESTs 2. 01 450914 A1743761 Hs. 142528 ESTs 2. 01 448275 BE514434 Hs. 20830 synapticRasGTPase activating protein 1 2. 01 405484 2. 01 436469 AK001455 Hs. 5198 Down syndrome critical region gene 2 2. 01 451273 NM014811 Hs. 26163 KIAA0649 gene product 2. 01 439696 W95298 Hs. 171882 ESTs 2. 01 432378 A1493046 Hs. 146133 ESTs 2. 01 417975 AA641836 Hs. 30085 HomosapienscDNA : FLJ23186 fis, clone L 2. 01 453665 AA626250 Hs. 181165 eukaryotic translation elongation factor 2. 01 419981 AA897581 Hs. 128773 ESTs 2. 01 445808 AV655234 Hs. 298083 ESTs 2. 01 435767 H73505 Hs. 117874 ESTs 2. 01 430466 AF052573 Hs. 241517 polymerase (DNA directed), theta 2. 01 452747 BE153855 Hs. 61460 ESTs 2. 01 422790 AA809875 Hs. 25933 ESTs 2. 01 443303 U67319 Hs. 9216 caspase 7, apoptosis-related cysteine pr 2. 01 433929 A1375499 Hs. 27379 ESTs 2. 01 410008 AA079552 gb : zm20h12. s1 SUatagene pancreas (93720 2. 01 448954 AB014564 Hs. 22616 KIAA0664 protein 2. 00 440774 Ai420611 Hs. 127832 ESTs 2. 00

451351 AW058261 Hs. 168213 EsTsWweaklysimilartoALu1 HUMANALUS 2. 00 442961 BE614474 Hs. 289074 Homo sapiens CDNA FLJ 13986 fis, clone Y7 2. 00 424420 BE614743 Hs. 146688 prostagiandin E synthase 2. 00 407154 H79677 gb : yu76g10. s1 Soaresfetalliverspleen 2. 00 410240 AL157424 Hs. 61289 synaptojanin 2 2. 00 426830 AA385751 Hs. 160392 ESTs 2. 00 435014 BE560898 Hs. 10026 ribosomal protein L17 isolog 2. 00 408620 A1918693 Hs. 81848 RAD21 (S. pombe) homolog 2. 00 432829 W60377 Hs. 57772 ESTs 2. 00 406752 A1285598 Hs. 217493 annexin A2 2. 00 TABLE 40A : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 408690 107490 1 AW864542 AA056567 AW882724 409965 1163011 AA079229AA079201AA078874 410008 116812 1 AA079552 BE142525 BE142527 410145 1178960 1 AW886300 AW887902 AW887893 AW886291 AW592641 411765 125700 1 H43346AA248302 AA095182 416713 1610889 1 T70174 H79244 T69850 H79151 418546 1766771 AA224827T59708T59843BE156903 419546 185766 1 AA244199 AA244272 H57440 419807 188252 1 R77402 AA262462 AA250988 R06794 420637 195241 1 AW976153 AA278945 AA747691 422058 2108151 AA862231 AA659033 AA302799 AA302798 422128 211994 1 AW881145 AA490718 M85637 AA304575 T06067 AA331991 422689 219896 1 AW856665M315006AW954733 425499 252539 1 T62489 T62634 AA828581 AA358569 430704 322217_1 AW813091 AW206655M484440 430785 323486 1 Z30201 AA486132 T72025 431120 3282641 AA492588AA492498AA492571 431300 331217 1 AA502346 BE159863 431322 331543 1 AW970622AA503009 AA502998 AA502989 AA502805T92188 432009 340251 AL137424BE007148T52277 432093 341283 1 H28383 AW972670 H28359 AA525808 433748 37385-1 Rl 2244 H71290 Al 110858 AF090916 AF075357 AA01 1531 434414 38585 1 AI798376 S46400 AW811617 AW811616 W00557 BE142245 AW858232 AW861851 AW858362 AA232351 AA218567 AA055556 AW858231 AW857541 AW814172 H66214 AW814398 AF134164 AA243093 AA173345 AA199942 AA223384 AA227092 AA227080 T12379 AA092174 T61139 AA149776 AA699829 AW879188 AW813567 AW813538 A) 267168 AA157718 AA157719 AA100472 AA100774 AA130756 AA157705 AA157730 AA157715 AA053524 AW849581 AW854566 C05254 AW882836 T92637 AW812621 AA206583 AA209204 BE156909 AA226824 A1829309 AW991957 N66951 AA527374 H66215 AA045564 AI694265 H60808 AA149726 AW195620 BE081333 BE073424 AW817662 AW817705 AW817703 AW817659 BE081531 H59570 437549 438403_1 M759149 AW751066 AW844933 438223 452646 1 AA781171 A1202139 A1202098 438993 467651 1 AA828995 AA834879 A1926361 439848 477806 1 AW979249 D63277 AA846968 443597 574739_1 Al078418 W80626 AW387769 446995 702707 1 A1355012 AW812856 447197 711623 1 R36075 A1366546 R36167 448437 763310 1 AW470125 A1734872 Api749559 AW856504 Al583942AW779036 AW843429AW844876 Al520713 AW847236 450190 827655 1 T51387 AW191595 T51271 A1686285 451105 859083_1 Al761324AW880941AW880937 451129 859870 1 BE072881 BE072946 A1762181 451237 863269 1 AW600293 AI767468 455666 1349545_1 BE065813 BE065788 BE065889 BE065832 455778 1364506 1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 456157 158261 1 AW979153 AA176967 AA826015 TABLE 40C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et at, (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 400514 9796594 Minus 78844-79025, 80850-80991, 89754-89941. 93750-93891 401519 6649315 Plus 15731S157950 401708 2951946 Plus 154511-155298 401866 8018106 Plus 73126-73623 402075 8117407 Plus 121907-122035, 122804-122921, 124019-124161, 124455-124610, 125672-126076 403055 8748904 Minus 109532-110225 403208 7630829 Minus 147706-147903, 148667-148804 403422 9665041 Minus 151169-151561 403485 9966528 Plus 2888-3001. 319&3532. 3655-4117 403776 7770611 Minus 1414-1513. 1624-1756 404171 9930793 Plus 173667-173783, 176876-177055 404253 9367202 Minus 55675-56055

404519 8152000 Plus 12817-13000 404567 7249169 Minus 101320-101501 405484 5922025 Plus 199214-199579, 199672-199920. 200262-200495 405545 1054740 Plus 118677-118807, 119091-119296, 121626-121823 405818 4071056 Plus 29055-29196 406399 9256288 Minus 63448-63554 TABLE 41A : ABOUT 634 SEQUENCES UP-REGULATED IN STOMACH CANCER Table 41A lists about 634 genes up-regulated in stomach cancer compared to normal adult tissues that are likely to be extracellular or cell-surface proteins. These were selected as for Table 40A and the predicted protein contained a structural domain that is indicative of extracellular localization (e. g. ig, fn3, egf, 7im domains). Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tide : Unigene gene bbe PSDomain : Protein Structural Domain R1 : Ratio of tumor to normal adult tissues Pkey ExAccn UnigenelD Unigene Title PSDomain R1 411243 A8039886 Hs. 69319 CA11 SS 30. 66 418007 M13509 Hs. 83169 matrix metaitop hemopexin, PepUdae_M1QSS 16. 94 448811 A1590371 Hs. 174759 ESTs TM 11. 08 409757 NM_001898 Hs. 123114 cystatin SN cystatin, SS 10. 38 421110 AJ250717 Hs. 1355 cathepsin E asp, SS 9. 11 428368 BE440042 Hs. 83326 mairixmetallop hemopexin, Pepúdase M10, SS 8. 66 406687 M31126 Hs. 272620 pregnancy speci hemopexin, TM, 7. 11 428651 AF196478 Hs. 188401 annexin A10 annexin, TM, 6. 86 425211 M18667 Hs. 1867 progatricsin (asp, TM, SS 6. 51 423673 BE003054 Hs. 1695 matrixmelallop hemopexin, Peptidase_M10, SS 6. 49 409683 U33317 Hs. 711 defensin, alpha defensins, Defensinpropep, SS 6. 39 428664 AK001666 Hs. 189095 similartoSALL zf-C2H2, TM, SS 6. 25 408380 AF123050 Hs. 44532 diubiquitin ubiquitin. 7im_3, ANF_receplor, sushi, 7im_1, TM, 5. 72 428953 AA306610 Hs. 194676 DKFZP434C013 pr arf, TNFR c6, DEAD, Stathmin, TM, SS 5. 46 450685 L15533 Hs. 423 pancreatitis-as lectin_c, TM, SS 5. 40 409187 AF154830 Hs. 50966 carbamoyl-phosp GATase, CPSase L chain, CPSase_sm_chain, MGS, TM, 5. 34 434206 AW136973 Hs. 288516 ESTs, Weakly si PH, TM, 5. 16 421346 Z34277 Hs. 103707 apomuån Cys knot, vwd, 5. 14 427585 D31152 Hs. 179729 coliagen, type Clq, Collagen, TM, SS 5. 06 425679 X05997 Hs. 159177 lipase, gastric abhydrolase, SS 4. 94 421582 AI910275 Hs. 1406 trefoil factor trefoil, trypsin, TM, SS 4. 93 422956 BE545072 Hs. 122579 hypothetical pr TM 4. 89 448105 AW591433 Hs. 170675 ESTs, Weakly si trypsin, TM, 4. 84 413385 M34455 Hs. 840 indoleamine-pyr IDO, TM, 4. 72 417866 AW067903 Hs. 82772 collagen, type TSPN, Collagen, COLFI, SS 4. 68 419278 AU076799 Hs. 1247 apolipoprotein Apolipoprotein, SS 4. 48 407811 AW190902 Hs. 40098 cysteineknots SS 4. 47 403422 SS 4. 38 403776 IL8, TM, SS 4. 32 418478 U38945 Hs. 1174 cyciin-dependen ank, TM, SS 4. 32 428242 H55709 Hs. 2250 leukemia inhibi LIF OSM, SS 4. 30 421341 AJ243212 Hs. 279611 deleted in maii SS 4. 30 428434 AW363590 Hs. 65551 ESTs, Weakly si SS 4. 13 409420 Z15008 Hs. 54451 laminin, gamma laminin EGF, laminin B, SS 4. 04 431611 U58766 Hs. 264428 tissue specific Epimerase, TM, SS 4. 04 413719 BE439580 Hs. 75498 small inducible IL8, SS 4. 03 409956 AW103364 Hs. 727 inhibin, belaA TGF-beta, TGFb_propeptide, SS 4. 01 422420 U03398 Hs. 1524 tumor necrosis TNF, TM, 4. 00 428227 AA321649 Hs. 2248 small inducible IL8, TM, SS 3. 91 422168 AA586894 Hs. 112408 StOOcalcium-bi efhand, TM, 3. 87 412140 AA219691 Hs. 73625 RAB6 interactin kinesin, TM, SS 3. 82 414812 X72755 Hs. 77367 monokine induce ILB. SS 3. 81 419833 AA251131 Hs. 220697 ESTs WHEP-TRS, TM, 3. 81 446232 Al281848 Hs. 165547 ESTs 7tm_3, TM, 3. 74 432398 AA307808 Hs. 2979 trefoil factor trefoil, TM, SS 3. 70 432867 AW016936 Hs. 233364 ESTs GSHPx, TM, SS 3. 66 424046 AF027866 Hs. 138202 serine (or cyst serpin, TM, 3. 65 414918 A1219207 Hs. 72222 Homo sapiens cD TM 3. 61 454293 H49739 Hs. 134013 ESTs, Moderate) TM 3. 59 442577 AA292998 Hs. 163900 ESTs TM 3. 57 426174 AA547959 Hs. 115838 ESTs SS 3. 53 418869 AW516565 Hs. 258279 ESTs Sema, TM, 3. 48 418054 NM 002318 Hs. 83354 lysyl oxidase-I Lysyl_oxidase, SRCR, SS 3. 45 442295 A1827248 Hs. 224398 Homo sapiens cD Collagen, COLFI, vwc, TM, SS 3. 44 425921 NM007231 Hs. 162211 solute carrier SNF, TM, 3. 44 421948 L42583 Hs. 111758 keratin6A hlamen8TM, 3-43 444783 AK001468 Hs. 62180 anillin (Drosop PH, TM, 437527 A1241019 Hs. 145644 ESTs PIPSKTM, SS 3. 37 433084 M18079 Hs. 282265 fatty acid bind lipocalin SS 3. 37 452401 Nom-007115 Hs. 29352 tumor necrosis Xiink, CUB, TM, SS 3. 36 458897 U85642 Hs. 138506 ESTs TM 3. 33 413808 J00287 Hs. 182183 caldesmon i asp, TM, SS 3. 33 411274 NM_002776 Hs. 69423 kallikrein 10 trypsin, TM, 3. 32

418406 X73501 Hs. 84905 cytokerafin 20 filament, TM, 3. 32 419559 Y07828 Hs. 91096 ringhngerpro zf-C3HC4, zf-B box, TM, 3. 32 423217 NM_000094 Hs. 1640 collagen, type fn3, Collagen, Kunitz BPTI, vwa, SS 3. 31 411558 AA102670 Hs. 70725 gamma-aminobuty neur_chan, TM, SS 3. 30 427722 AK000123 Hs. 180479 hypotheticatpr PH. SS 3. 30 422310 AA316622 Hs. 98370 cytochromeP540 p450. SS 3. 30 411263 BE297802 Hs. 69360 kinesin-like 6 kinesin, TM, 3. 29 443426 AF098158 Hs. 9329 chromosome 20 o TM 3. 28 452121 NM004081 Hs. 70936 deleted in azoo TM 3. 27 447342 A1199268 Hs. 19322 ESTs TM, SS 3. 25 452699 AW295390 Hs. 213062 ESTs TM 3. 23 425188 AK002052 Hs. 155071 hypotheUcal pr TM 3. 23 400289 X07820 Hs. 2258 matrix metatbp hemopexin. SS 3. 21 408524 D87942 Hs. 46328 fucosyltransfer Giyco_iransf_11, TM, SS 3. 20 437897 AA770561 Hs. 146170 hypothetical pr TM 3. 20 453922 AF053306 Hs. 36708 budding uninhib TM 3. 19 406690 M29540 Hs. 220529 carcinoembryoni ig, TM, SS 3. 19 416209 AA236776 Hs. 79078 MAD2 (mitoUc a HORMA, SS 3. 16 408113 T82427 Hs. 194101 HomosapienscD 7im 3, TM, 3. 14 425465 L18964 Hs. 1904 protein kinase Ski_Sno, DAG_PE-bind, OPR, pkise, pkise_C, TM, SS 3. 13 419216 AU076718 Hs. 164021 small inducible IL8, TM, SS 3. 13 418203 X54942 Hs. 83758 CDC28 protein k CKS, TM, 3. 12 417315 Al080042 Hs. 180450 ribosomatprote TM. SS 3. 11 433001 AF217513 Hs. 279905 doneHQ0310PR TM, SS 3. 11 459587 AA031956 gb : zk15eO4. s1 S LIM, TM, 3. 11 421379 Y15221 Hs. 103982 small inducible ILB, TM, SS 3. 10 414774 X02419 Hs. 77274 plasminogen act kringle. trypsin, SS 3. 10 407289 AA135159 Hs. 203349 Homo sapiens cD TM 3. 09 447519 U46258 Hs. 23448 ESTs histone, Ribosomal_L22e, TM, 3. 08 448045 AJ297436 Hs. 20166 prostate stem c TM, SS 3. 07 431956 AK002032 Hs. 272245 Homo sapiens cD RA, SS 3. 06 409632 W74001 Hs. 55279 serine (or cyst serpin, TM, 3. 05 454034 NM 000691 Hs. 575 aldehyde dehydr aldedh, TM, 3. 05 436481 AA379597 Hs. 5199 HSPC150 protein UQ_con, TM, 3. 05 428987 NM 004751 Hs. 194710 glucosaminyl (N Branch, TM, SS 3. 04 424252 AK000520 Hs. 143811 hypothefical pr casein-kappa, SS 3. 04 436291 BE568452 Hs. 5101 protein regulat TM 3. 03 411789 AF245505 Hs. 72157 Homo sapiens ad ig, LRRCT, SS 3. 02 417956 AA210704 Hs. 190465 ESTs sushi, SS 3. 02 408908 BE296227 Hs. 48915 serinefthreonin pkise, TM, SS 3. 01 422330 D30783 Hs. 115263 epiregulin EGF, TM, SS 3. 01 425071 NM 013989 Hs. 154424 deiodinase, iod T4 deiodise, TM, SS 3. 00 425761 AW664214 Hs. 196729 ESTs SH3, TM, 2. 99 432978 AF126743 Hs. 279884 DNAJ domain-con DJ, TM, 2. 99 418546 AA224827 gb : nc32gO4. s1 N vwa, integrin A, FG-GAP, TM, SS 2. 99 425371 D49441 Hs. 155981 mesothelin TM, SS 2. 99 422440 NM 004812 Hs. 116724 atdo-ketoreduc aidoketred. TM. 2. 98 439453 BE264974 Hs. 6566 thyroid hormone AAATM, 2. 98 413278 BE563085 Hs. 833 interferon-sUm ubiquitin, TM, 2. 97 428450 NM014791 Hs. 184339 KIAA017 gene p pkise, KA1, TM, 2. 95 424345 AK001380 Hs. 145479 Homo sapiens cD TM, SS 2. 95 433133 AB027249 Hs. 104741 PDZ-binding kin pkise, TM, 2. 94 432269 NM 002447 Hs. 2942 macrophage stim pkise, Sema, Plexin_fepeaLTIG, TM, SS 2. 94 432917 NM014125 Hs. 279812 PR00327 protein TM 2. 94 432731 R31178 Hs. 287820 fibronectint SS 2. 93 420552 AK000492 Hs. 98806 hypothetical pr SS 2. 92 428303 AW974476 Hs. 183601 regulator of G-RGS, TM, 2. 92 409687 T51125 Hs. 8493 ESTs Ets, SAM_PNT, TM, 2. 91 457288 AA521458 Hs. 192738 ESTs TM 2. 89 456181 L36463 Hs. 1030 ras inhibitor RA, VPS9, TM, SS 2. 89 450190 T51387 gb : yb20e08. r1 S SH3, TM, 2. 88 430204 AA618335 Hs. 146137 ESTs, Weakly si TM 288 434808 AF155108 Hs. 256150 ESTs, Highly si TM 2. 87 450983 AA305384 Hs. 25740 ER01 (S. cerevi SS 2. 87 418670 AA601036 Hs. 285083 ESTs TM 2. 87 416661 AA634543 Hs. 79440 IGF-II mRNA-bin KH-domain, TM, 2. 87 435099 AC004770 Hs. 4756 flapsiructure-XPG l, XPG_N, TM, 2. 86 402075 serpin, TM, 2. 84 410681 AW246890 Hs. 65425 calbindin 1, (2 eRhand, FHA, BRCT, adh_shoriæh_short_C2, TM, 2. 83 439867 AA847510 Hs. 161292 ESTs TM 2. 83 443715 At583187 Hs. 9700 cyclin E1 cyclin, TM, SS 2. 83 417366 BE185289 Hs. 1076 small proline-r Cornifin, TM, 2. 83 422283 AW411307 Hs. 114311 CDC45 (cell div CDC45, TM, SS 2. 82 404567 HECT, zf-UBR1, TM, 2. 82 422158 L10343 Hs. 112341 protease inhibi wap, SS 2. 82 449224 AW995911 Hs. 299883 hypothetical pr (n3, TM, 407584 W25945 Hs. 18745 ESTs PK, SS 2. 81 453884 AA355925 Hs. 36232 KIAA0186 gene p TM 2. 81 449032 AA045573 Hs. 22900 nuclear factor bZIP. Chromo shadow, TM, SS 2. 80 422809 AK001379 Hs. 121028 hypothetical pr IQ, TM, 2. 79 449722 BE280074 Hs. 23960 cyclin B1 cyclin, TM, 2. 79 453028 AB006532 Hs. 31442 RecQ protein-li DEAD, helicase_C, TM, 2. 78 421777 BE562088 Hs. 108196 HSPC037 protein TM 2. 78

452571 W31518 Hs. 34665 ESTs TM 2. 77 422675 BE018517 Hs. 119140 eukaryoúc iran elF-Sa, TM, 2. 77 400298 AA032279 Hs. 61635 six transmembra TM 2. 76 414569 AF109298 Hs. 118258 prostate cancer TM 2. 76 449378 AW664026 Hs. 59892 ESTs TM 2. 75 423903 M57765 Hs. 1721 mteneukintt TM. SS 2. 75 431104 AW970859 Hs. 269109 ESTs Sema, TM, SS 2. 75 452940 AA029722 Hs. 20279 ESTs 7tm_1. TM, SS 2. 74 432201 A1538613 Hs. 135657 ESTs trypsin, TM, 2. 73 414617 Api339520 Hs. 20524 ESTs, Moderatel hexokise, TM, 2. 73 444301 AK000136 Hs. 10760 hypothetical pr LRR, TM, 2. 72 426711 AA383471 Hs. 180669 conserved gene TM 2. 71 429432 Al678059 Hs. 202676 synaptonemal co TM 2. 71 450506 NM 004460 Hs. 418 fibroblastacti Peptidase S9, DPPIV_N term, SS 2. 71 427528 AU077143 Hs. 179565 minichromosome MCM, TM, SS 2. 71 418801 AA228366 Hs. 115122 ESTs integrin A, FG-GAP, TM, SS 2. 71 429486 AF155827 Hs. 203963 hypotheUca pr SNF2_N, helicae_C, TM, 2. 71 408366 AW511255 Hs. 258082 ESTs SS 2. 70 406399 kazak, TM, SS 2. 69 446269 AW263155 Hs. 14559 hypothetical pr TM 2. 68 426514 BE616633 Hs. 301122 bonemorphogene TGF-beta, TGFb_propeplide, TM, SS 2. 67 417079 U65590 Hs. 81134 inlerieukin 1 r IL1, SS 2. 67 444754 T83911 Hs. 11881 transmembrane 4 TM, SS 2. 67 424687 J05070 Hs. 151738 matrix metailop fn2, hemopexin, Peptidase_M10, SS 2. 66 439979 AW600291 Hs. 6823 hypothetical pr TM 2. 65 430832 A1073913 Hs. 100686 ESTs, Weakly si TM, SS 2. 65 429170 Nom001394 Hs. 2359 dual specificit DSPc, Rhodanese, TM, 2. 64 450400 A1694722 Hs. 279744 ESTs TM 2. 64 435380 AA679001 Hs. 192221 ESTs Occludin, TM, SS 2. 64 432375 BE536069 Hs. 2962 S100calcium-bi S 100, efhand, TM, SS 2. 63 453700 AB009426 Hs. 560 apolipoprotein dCMP_cyt deam. sugar_U. TM, SS 2. 63 422938 NM 001809 Hs. 1594 centromere prot histone, TM, 2. 63 453134 AA032211 Hs. 118493 ESTs adh short, TM, SS 2. 63 420727 H75701 Hs. 99886 complement comp sushi, 2. 62 408868 AW292286 Hs. 255058 ESTs TM 2. 62 414972 BE263782 Hs. 77695 KIAA0008 gene p TM 2. 62 403055 filament, TM, SS 2. 62 447400 AK000322 Hs. 18457 hypothetical pr zf-C3HC4, TM, 2. 61 413753 U17760 Hs. 301103 Human DNAseque laminin_EGF, laminin_Ntemm, SS 2. 61 433220 A1076192 Hs. 131933 ESTs TM 2. 60 436251 BE515065 Hs. 5092 nucleolar prote Nop, TM, SS 2. 60 448988 Y09763 Hs. 22785 gamma-aminobuty neur_chan, TM, SS 2. 60 425463 AK000740 Hs. 157986 hypothetical pr TM 2. 60 435370 A1964074 Hs. 225838 ESTs EGF, fn3, fibnnogen_C, TM, SS 2. 59 432215 AU076609 Hs. 2934 ribonucleoUde ribonucleo_red, ribonuc_red_lg, TM, 2. 59 409142 AL136877 Hs. 50758 chromosome-asso SMC_N, TM, SS 2. 59 443919 A1091284 Hs. 135224' ESTs adh. shorfTM. SS 2. 58 413268 AL039079 Hs. 75256 regulator of G-RGS, TM, 2. 58 404519 defensins, SS 2. 58 414998 Nom-002543 Hs. 77729 oxidised low de TM 2. 57 429597 NM003816 Hs. 2442 a disintegrin a TM. SS 2. 57 426841 A1052358 Hs. 193726 ESTs asp, TM, SS 2. 57 416768 AA363733 Hs. 1032 regenerating is ectinc. SS 2. 57 417933 X02308 Hs. 82962 thymidylate syn thymidylat_syntSS 2. 56 441384 AA447849 Hs. 288660 protease, serin TM 2. 56 451939 U80456 Hs. 27311 single-minded (PAC, PAS, BPL, BPL_C, TM, 2. 56 418867 D31771 Hs. 89404 msh (Drosophila homeobox, TM, 2. 55 416065 BE267931 Hs. 78996 prolgerafing c TM 2. 55 431890 X17033 Hs. 271986 integrin, alpha vwa, integrin A, FG-GAP, TM, SS 2. 55 407830 NM 001086 Hs. 587 arylacetamided COesterase, 7tm_t, TM, SS 2. 55 434815 AF155582 Hs. 46744 coret UDP-galac SS 2. 54 435647 A1653240 Hs. 49823 ESTs TM 2. 54 459306 AW578452 Hs. 232988 ESTs, Weakly si TM, SS 2. 54 414361 A1086138 Hs. 204044 ESTs TM 2. 54 425782 U66468 Hs. 159525 cell growth reg SS 2. 53 416984 H38765 Hs. 80706 diaphorase (NAD TM 2. 53 431183 NM006855 Hs. 250696 KDEL (Lys-Asp-G ER_iumenJeceptlRK, DEAD, helicase_C, TM, SS 2. 53 456743 A1630124 Hs. 7434 ESTs TM 2. 53 410268 AA316181 Hs. 61635 six transmembra TM 2. 52 424905 NM 002497 Hs. 153704 NIMA (never in pkise, TM, 2. 52 432657 AA831815 Hs. 270940 ESTs TM 2. 51 434080 Api820719 Hs. 154662 hypotheticatpr DJCXXCXGXG. TM. SS 2. 51 418969 W33191 Hs. 28907 hypothetical pr SH3, TM, 2. 51 431808 M30703 Hs. 270833 amphiregulin (s EGF, TM, SS 2. 51 429093 NM 000253 Hs. 195799 microsomalirig Vitellogenin_N, TM, SS 2. 50 447634 AW967902 Hs. 5152 Homo sapiens cD TM 2. 50 436393 AW022213 Hs. 143617 ESTs Galactosyl_T_2, TM, SS 2. 50 453751 R36762 Hs. 101282 Homo sapiens mR TM 2. 49 445865 A1262584 Hs. 145575 ESTs SS 2. 49 414883 AA926960 Hs. 77550 CDC28 protein k CKS, TM, 2. 49 406747 A1925153 Hs. 217493 annexin A2 TM 2. 49 446921 AB012113 Hs. 16530 small inducible IL8, SS 2. 49 426322 J05068 Hs. 2012 transcobalamin Coba) aminbind. TM. SS 2. 48

422515 AW500470 Hs. 117950 multifunctional AIRC, SAICAR_synt, TM, 2. 48 447030 AW444659 Hs. 232184 ESTs TM 2. 48 448454 NM005879 Hs. 21254 TRAF interact zf-C3HC4, TM, 2. 48 419092 J05581 Hs. 89603 mucin 1, iransm SEA, TM, SS 2. 48 409640 U78722 Hs. 55481 zinc finger pro zf-C2H2, SCAN, TM, 2. 48 404171 sodfe, TM. 2. 47 414747 U30872 Hs. 77204 centromere prot SS 2. 47 410406 A1969703 Hs. 301842 ESTs FGGY, TM, 2. 47 452220 BE158006 Hs. 212296 ESTs FG-GAP, TM, SS 2. 46 421493 BE300341 Hs. 104925 ectodermal-neur BTB, Kelch, TM, 2. 46 444838 AV651680 Hs. 208558 ESTs integrin_A, FG GAP, TM, SS 2. 46 413816 AW958181 Hs. 189998 ESTs AMP-binding, G_glu_transpepl, TM, 2. 46 436613 AA972691 Hs. 192974 HomosapienscD TM, SS 2. 45 432874 W94322 Hs. 279651 melanoma inhibi SH3, SS 2. 45 425397 J04088 Hs. 156346 topoisomerase (HATPase_c, SS 2. 45 422363 T55979 Hs. 115474 replication fac TM 2. 45 431924 AK000850 Hs. 272203 Homo sapiens cD SH3, TM, 2. 44 431457 NM 012211 Hs. 256297 integrin, alpha FG-GAP, vwa, TM, SS 2. 44 416498 U33632 Hs. 79351 potassium chann TM 2. 44 428484 AF104032 Hs. 184601 sotutecarrier aapermeases. TM. 2. 43 431958 X63629 Hs. 2877 cadherin 3, typ cadherin, Cadhenn_C term, TM, SS 2. 43 413833 Z15005 Hs. 75573 centromere prot kinesin, TM, 2. 43 407243 AA058357 Hs. 74466 carcinoembryoni TM, SS 2. 43 410044 BE566742 Hs. 58169 highly expresse TM, SS 2. 43 424273 W40460 Hs. 144442 phospholipae A phoslip, TM, SS 2. 42 409533 AW969543 Hs. 21291 mitogen-acbvat TM, SS 2. 42 419741 Nom007019 Hs. 93002 ubiquitin cam UQ con, efhand, TM, SS 2. 42 449987 AW079749 Hs. 184719 ESTs, Weakly si ABC lran, ABC membrane, TM, 2. 42 433159 AB035898 Hs. 150587 kinesin-like pr kinesin, Myosin tail, TM, SS 2. 42 439396 BE562958 Hs. 74346 ESTs, Weakly si SS 2. 42 426427 M86699 Hs. 169840 TTK protein kin pkise, TM, 2. 41 434725 AK000796 Hs. 4104 hypothetical pr TM 2. 41 433312 A1241331 Hs. 131765 ESTs zf-C2H2, SS 2. 41 407047 X65965 gb : H. sapiens SO sodfe, TM, 2. 41 419220 AA811938 Hs. 291759 ESTs TM, SS 2. 40 416530 U62801 Hs. 79361 kallikrein 6 (n trypsin, pro_isomerase, TM, SS 2. 40 435219 AA676349 Hs. 190331 ESTs TM 2. 40 418322 AA284166 Hs. 84113 cyclin-dependen SS 2. 40 404253 histone, TM, SS 2. 40 428970 BE276891 Hs. 194691 retinoic acid i 7tm3, TM, 2. 40 418693 A1750878 Hs. 87409 thrombospondin EGF, TSPN, isp_1, tsp3, vwc, SS 2. 39 451237 AW600293 gb : EST00049 pGE TM 2. 39 407756 AA116021 Hs. 38260 ubiquitin speci UCH-1, UCH-2, SS 2. 39 437935 AW939591 Hs. 5940 hypothetical pr TM, SS 2. 39 445625 BE246743 Hs. 288529 Homo sapiens cD TM 2. 39 435937 AA830893 Hs. 119769 ESTs TM 2. 39 438993 AA828995 gb : od77bO8. s1 N integnn_B, TM, SS 2. 38 422082 AA016188 Hs. i 11244 hypothetical pr TM 2. 38 450396 AU077002 Hs. 24950 regulator of G-RGS, TM, 2. 38 422578 AF239666 Hs. 1545 caudal type hom homeobox, SS 2. 38 428070 T63918 Hs. 182313 retinol-binding lipocalin, TM, 2. 38 416111 AA033813 Hs. 79018 chromatinassem TM. SS 2. 37 433345 AI681545 Hs. 152982 Homo sapiens cD TM 2. 37 427557 NM 002659 Hs. 179657 plasminogenæt UPAR_LY6, SS 2. 37 423554 M90516 Hs. 1674 glutamine-fruct GATase_2, SIS, TM, SS 2. 37 453204 R10799 Hs. 191990 ESTs TM 2. 37 425081 X74794 Hs. 154443 minichromosome MCM, TM, 2. 36 434682 AA827165 Hs. 191958 ESTs TM 2. 36 414108 Api267592 Hs. 75761 SFRS protein ki pkise, TM, 2. 36 417900 BE250127 Hs. 82906 CDC20 (cell div WD40, TM, 2. 36 428046 AW812795 Hs. 155381 ESTs, Moderate ank, SS 2. 36 448019 AW947164 Hs. 195641 ESTs TM 2. 36 431753 X76029 Hs. 2841 neuromedin U NMU, TM, SS 2. 36 410361 BE391804 Hs. 62661 guanylate bindi GBP, TM, SS 2. 36 418526 BE019020 Hs. 85838 solute carrier MCT, TM, SS 2. 36 444478 W07318 Hs. 240 M-phase phospho kinesin, SS 2. 36 436961 AW375974 Hs. 156704 ESTs TM 2. 35 408194 AA601038 Hs. 191797 ESTs TM 2. 35 438578 AA811244 Hs. 164168 ESTs fommyl_transf, AIRS, GARS, TM, 2. 35 429183 AB014604 Hs. 197955 KIAA0704 protei TM 2. 35 453900 AW003582 Hs. 226414 ESTs. Weakiy si TM 2. 33 432877 AW974111 Hs. 292477 ESTs Ets, SAM_PNT, TM, 2. 33 451928 A1823801 Hs. 30315 ESTs TM 2. 33 418245 AA088767 Hs. 83883 transmembrane, Idl recept_a, TM, SS 2. 33 435106 AA100847 Hs. 193380 ESTs, Highly si TM 2. 33 432193 AA372264 Hs. 273193 hypothetical pr TM, SS 2. 33 449532 W74653 Hs. 271593 ESTs TM 2. 33 409703 NM 006187 Hs. 56009 2'-5'oligoadeny NTP transf 2, TM, SS 2. 33 419373 NM 003244 Hs. 90077 TG-interacting homeobox, SS 2. 32 435607 W73428 Hs. 8750 uncharacterized SS 2. 32 405818 TM, SS 2. 32 444371 BE540274 Hs. 239 forkheæ box M1 Fork_head, SS 2. 32 432675 Al791855 Hs. 105884 ESTs PDEae, TM, 2. 32

411773 NM 006799 Hs. 72026 protease, serin trypsin, SS 2. 31 434775 AA648983 Hs. 212911 ESTs TM, SS 2. 31 422611 AA158177 Hs. 118722 hucosyllransfer SS 2. 31 419493 AF001212 Hs. 90744 proteasome (pro SS 2. 31 424435 AB011167 Hs. 146957 KIAA0595 protei TM 2. 30 409262 AK000631 Hs. 52256 hypothetical pr WD40, TM, SS 2. 30 428125 AA393071 Hs. 182579 leucine aminope Peptidase_M17, TM, SS 2. 30 417655 AA780791 Hs. 14014 ESTs, Weakly si TM 2. 29 407287 Al678812 Hs. 201658 ESTs, Weakly si ras, TM, SS 2. 29 428923 BE047698 Hs. 188785 ESTs TM, SS 2. 29 452203 X57522 Hs. 158164 ATP-binding ca ABC_-ran, ABC_membrane, TM, 2. 29 409402 AF208234 Hs. 695 cystatin B (ste cystatin, SS 2. 29 419359 AL043202 Hs. 90073 chromosome segr TM, SS 2. 29 451999 AW176401 Hs. 27424 DEAD/H (Asp-Glu TM, SS 2. 29 400811 AF219139 Hs. 87726 KIAA0154 protei Cobalamin bind, SS 2. 29 420931 AF044197 Hs. 100431 small inducible IL8, TM, SS 2. 28 425247 Nom-005940 Hs. 155324 matrix metallop hemopexin, Peptidase_M10, TM, SS 2. 28 438170 A1916685 Hs. 194601 ESTs 2-Hacid_DH, TM, 2. 28 445378 AV653564 Hs. 226946 ESTs TM 2. 28 428048 AA705745 Hs. 185070 ESTs AMP-binding, TM, 2. 28 414696 AF002020 Hs. 76918 Niemann-Pick di Patched, TM, SS 2. 27 433535 AF111106 Hs. 3382 protein phospha TM 2. 27 421155 H87879 Hs. 102267 lysyl oxidase Lysyl-pxidase. SS 2. 27 405545 ABC_Uan, ABC_membrane, TM, SS 2. 27 445537 AJ245671 Hs. 12844 EGF-like-domain EGF, SS 2. 27 423634 AW959908 Hs. 1690 heparin-binding TM, SS 2. 26 407742 AF186252 Hs. 38084 sulfotransfera Sulfotransfer, SS 2. 26 428330 L22524 Hs. 2256 matrix melia'loup Peptidase. M10. SS 2. 26 429731 AK001592 Hs. 212172 beta, beta-carol TM 2. 26 400514 p450. TM, SS 2. 26 431846 BE019924 Hs. 271580 uroplakin 1B transmembrane4, TM, SS 2. 26 426010 AA136563 Hs. 1975 Homo sapiens cD TM 2. 26 437641 AA811452 Hs. 291911 ESTs TM 2. 26 411393 AW797437 Hs. 69771 B-factor, prope sushi, trypsin, vwa, DEAD, mm, EGF, fn3, hbrinogen_C, SS 2. 26 414809 Api434699 Hs. 77356 transfemn rec PA, Ribosomal S2. TM, 2. 25 419488 AA316241 Hs. 90691 nucleophosmin/n SS 2. 25 434540 NM 016045 Hs. 5184 TH1 drosophila TM 2. 25 410196 Api936442 Hs. 59838 hypothetical pr UBACT_repeat, TM, 2. 25 456844 Api264155 Hs. 152981 CDP-diacylglyce Cytidylyltrans, TM, 2. 25 408353 BE439838 Hs. 44298 hypothetical pr Ribosomal_S17, TM, 2. 25 448753 AL048858 Hs. 224355 ESTs, Weakly si TM 2. 25 428479 Y00272 Hs. 184572 cell division c pkise, TM, SS 2. 24 424971 AA479005 Hs. 154036 tumor suppressi ion-trans, PH, TM, 2. 24 432673 AB028859 Hs. 278605 ER-associated D DJ, DJ C, TM, SS 2. 24 409432 D49372 Hs. 54460 small inducible ILB, TM, SS 2. 24 429925 NM000786 Hs. 226213 cytochrome P450 p450, TM, SS 2. 24 445413 AA151342 Hs. 12677 CGI-147 protein UPF0099, TM, SS 2. 23 447532 AK000614 Hs. 18791 hypothet ! ca) pr TM 2. 23 423515 AA327017 Hs. 162204 ESTs SS 2. 23 444743 AA045648 Hs. 11817 nudix (nucleosi mutT, TM, 2. 23 434518 H56995 Hs. 37372 Homo sapiens DN TM 2. 23 435602 AF217515 Hs. 283532 uncharacterized TM, SS 2. 23 449974 AW970948 Hs. 269403 ESTs TM, SS 2. 23 424927 AW973666 Hs. 153850 hypothetical pr TM 2. 23 414420 AA043424 Hs. 76095 immediate early TM 2. 23 431840 AA534908 Hs. 2860 POU domain, cla homeobox, pou, TM, SS 2. 23 452930 AW195285 Hs. 194097 ESTs SS 2. 23 436391 AJ227892 Hs. 146274 ESTs SS 2. 23 439186 A1697274 Hs. 6487 Xq28, 2000bpse Epimerase, SS 2. 23 414732 AW410976 Hs. 77152 minichromosome MCM, TM, 2. 22 411835 U29343 Hs. 72550 hyaluronan-medi TM 2. 22 438223 AA781171 gb : aj24d05. sl S myosin head, TM, 2. 22 450149 AW969781 Hs. 293440 ESTs, Moderate TM 2. 22 401519 filament, TM, 2. 22 441794 AW197794 Hs. 253338 ESTs ank, TM, 2. 22 408901 AK001330 Hs. 48855 hypothetical pr TM 2. 21 434423 NM006769 Hs. 3844 LIM domain only LIM, TM, 2. 21 432140 AK000404 Hs. 272688 hypothetical pr SS 2. 21 423453 AW450737 Hs. 128791 CGI-09 protein Granin, CDP-OH_P Diransf, TM, 2. 21 428438 NM_001955 Hs. 2271 endothelin 1 endothelin, TM, SS 2. 21 421470 R27496 Hs. 1378 annexin A3 annexin, TM, SS 2. 21 440381 AA917808 Hs. 190495 ESTs TM, SS 2. 20 453779 N35187 Hs. 43388 ESTs TM, SS 2. 20 433627 AF078866 Hs. 284296 Homo sapiens cD SURF4, TM, 2. 20 417944 AU077196 Hs. 82985 collagen, type COLFI, Collagen, vwc, TM, SS 2. 20 422689 AW856665 gb : RC3-CT0297-2 SNF2_N, TM, 2. 20 448457 H65629 Hs. 245997 ESTs TM, SS 2. 20 426125 X87241 Hs. 166994 FAT tumor suppr EGF, cadherin, laminin_G, TM, SS 2. 20 430603 AA148164 Hs. 247280 HBV associated zf-C3HC4, TM, 2. 20 425274 BE281191 Hs. 155462 minichromosome MCM, TM, 2. 20 452679 Z42387 Hs. 4299 Homo sapiens cD TM 2. 20 410619 BE512730 Hs. 65114 keratin 18 filamenl, TM, 2. 20 424332 AA338919 Hs. 101615 ESTs SS 2. 20

418661 Nom-001949 Hs. 1189 HumanmRNAfor E2F_TDP, TM, SS 2. 20 419341 N71463 Hs. 118888 ESTs, Weaklysi UPF0016, TM, SS 427920 Z11502 Hs. 181107 annexin A13 annexin, TM, 403208 lectin c, TM, SS 2. 19 422596 AF063611 Hs. 118633 Z-Soligoadeny ubiquiún, SS 2. 19 444261 AA298958 Hs. 10724 MDS023 protein TM 2. 19 423401 NM001992 Hs. 128087 coagulafon fæ 7tm_1, TM, SS 2. 18 453450 AW797627 Hs. 89474 ADP-ribosylatio SS 2. 18 444334 BE296785 Hs. 10848 KIAA0187genep SS 2. 18 437616 A1797163 Hs. 207954 ESTs SMC_N, TM, SS 2. 18 451807 W52854 Hs. 27099 DKFZP564J0863 p TM 2. 18 430441 BE398091 Hs. 6880 DKFZP434D156 pr TM 2. 18 411678 Api907114 Hs. 71465 squaleneepoxid Monooxygese, TM, 2. 18 452291 AF015592 Hs. 28853 COC7 (cell divi pkise, TM, 2. 18 444342 NM 014398 Hs. 10887 similartolyso Lamp, TM, SS 451099 R52795 Hs. 25954 interleukin 13 fn3, TM, SS 2. 18 425873 NM_013390 Hs. 160417 transmembrane p TM 2. 17 417404 Nom007350 Hs. 82101 plecksNnhomo TM 2. 17 446995 Api355012 gb : qu16dl0. xl N TM 2. 17 439961 AA857451 Hs. 269696 ESTs TM 2. 17 429125 AA446854 Hs. 271004 ESTs TM 2. 17 407103 AA424881 Hs. 256301 ESTs TM 2. 17 415116 AA160363 Hs. 269956 ESTs ER lumen receptTM, SS 2. 17 440052 Ai633744 Hs. 195648 ESTs PAC, TM, SS 2. 17 423961 D13666 Hs. 136348 osteoblast spec Fasciclin, TM, SS 2. 17 431070 AW408164 Hs. 249184 transcription f FHA, SS 2. 16 443599 A1079559 Hs. 134125 ESTs TM 2. 16 427258 AA400091 Hs. 39421 ESTs TM 2. 16 418113 Al272141 Hs. 83484 SRY (sex determ HMG box, TM, 2. 16 450835 BE262773 Hs. 25584 hypothetical pr ArfGap, SS 2. 16 449057 AB037784 Hs. 22941 KIAA1363 protei TM 2. 16 448153 Y10805 Hs. 20521 HMT1 (hnRNP met TM, SS 2. 16 424653 AW977534 Hs. 151469 calcium/calmodu Guanylate_kin, PDZ, pkise, SH3, TM, 2. 16 431341 AA307211 Hs. 251531 proteasome (pro proteasome, TM, 2. 16 452865 A1924046 Hs. 119567 ESTs PMP22_Oaudin, TM, SS 2. 16 432789 D26361 Hs. 3104 KIAA0042 gene p TM 2. 16 438580 AA811262 Hs. 299202 ESTs pkise, TM, 2. 16 422192 AA305159 Hs. 113019 f) s485 SS 2. 15 425607 U09860 Hs. 158333 protease, serin Idl_n3cepi_a, irypsin, CUB, SRCR, MAM, SEA, TM, SS 2. 15 447289 AW247017 Hs. 36978 melanoma antige 3Beta_HSD, Epimerae, MAGE, TM, 2. 15 447674 BE270640 Hs. 19192 cyclin-dependen pkise, TM, 2. 15 441021 AW578716 Hs. 7644 Ht histonefami linker histone, TM, 2. 15 426471 M22440 Hs. 170009 transforming gr EGF, IM, SS 2. 15 431941 AK000106 Hs. 272227 Homo sapiens cD pkise, Furin-like, TM, SS 2. 15 414761 AU077228 Hs. 77256 enhancer of zes SET, TM, 2. 15 410407 X66839 Hs. 63287 carbonic anhydr carb anhydrase, TM, SS 2. 15 420900 AL045633 Hs. 44269 ESTs Md_Xan dh_C, FAD_binding_5, TM, 2. 15 419239 AA468183 Hs. 184598 Homo sapiens cD TM 2. 15 452721 AJ269529 Hs. 30377 Homo sapiens ES TM 2. 15 410664 NM 006033 Hs. 65370 lipase, endothe Ribosomal L22, 1ipase, PLAT, TM, SS 2. 14 452835 AK001269 Hs. 30738 hypothetical pr TM 2. 14 452092 BE245374 Hs. 27842 hypothetical pr Acyltransferase, TM, SS 2. 14 401708 SS 2. 14 411400 AA311919 Hs. 69851 GAR1 protein TM 2. 14 448526 AB028946 Hs. 21361 KIAA1023 protei TM 2. 14 421175 A1879099 Hs. 102397 GIOT-3 for gona zf-C2H2, KRAB, TM, SS 2. 14 413511 At627178 Hs. 75412 Argininerichp TM 2. 13 432945 AL043683 Hs. 271357 ESTs, Weakly si PK, SS 2. 13 418592 X99226 Hs. 284153 Fanconi anemia, TM 2. 13 425298 AK000209 Hs. 155556 hypothetical pr TM 2. 13 450956 AW193531 Hs. 205647 ESTs, Moderate pkise, TM, SS 2. 13 419569 A1971651 Hs. 91143 jagged 1 (Alagi EGF, DSL, TM, SS 2. 13 421508 NM 004833 Hs. 105115 absentin melan TM 2. 13 413670 AB000115 Hs. 75470 hypothetical pr TM 2. 13 422783 AA598956 Hs. 120439 ethanoiamineki Cho) inekise. TM. 2. 13 410418 D31382 Hs. 63325 iransmembrane p rypsin, ldl_recep-_a, TM, SS 2. 13 414860 BE255593 Hs. 77502 methionine aden S-AdoMet_synt, SS 2. 13 425860 L29339 Hs. 1964 solutecarrier SSF, Ribosomal Sl7e, TM, 2. 13 414839 X63692 Hs. 77462 DNA (cytosine-5 zf-CXXC, BAH, TM, SS 2. 13 437050 AA766420 Hs. 291606 ESTs TM 2. 13 430217 N47863 Hs. 180450 dbosomal prote TM, SS 2. 13 409012 AL117435 Hs. 49725 DKFZP4341216 pr RhoGEF, TM, 2. 12 428365 AA295331 Hs. 183861 Homo sapiens cD TM 2. 12 410839 NM 006849 Hs. 66581 protein disulfi thiored, TM, 2. 12 450510 AA010056 Hs. 242998 ESTs TM, SS 2. 12 427475 AA403151 Hs. 191605 ESTs SS 2. 12 433748 R12244 gb : yf33c12. r1 S AMP-binding, TM, 2. 12 415138 C18356 Hs. 78045 UssuefaCorp Kunigz_BPTl, G-gamma, TM, SS 2. 11 414788 X78342 Hs. 77313 cyclin-dependen pkise, TM, SS 2. 11 415474 NM014252 Hs. 78457 solute carrier mito carr, TM, 2. 11 416472 AA180756 Hs. 193094 ESTs, Moderate TM 2. 11 410718 A1920783 Hs. 191435 ESTs SQS_PSY, TM, SS 2. 11 425811 AL039104 Hs. 159557 karyopherin alp Armadillo seg, IBB, TM, SS 2. 11

447197 R36075 gb : yh88bOi. sl S SDF, TM, 2. 11 431621 AW292329 Hs. 163481 ESTs PH, Band_41, TM, SS 2. 11 433849 BE465884 Hs. 280728 ESTs SS 2. 11 438038 At732629 Hs. 194161 ESTs, Weakly si Cytidylyltrans, TM, 2. 11 422032 AA476966 Hs. 110857 polymerase (RNA TFIIS, TM, SS 2. 11 409717 AW452871 Hs. 56043 CG-115 protein TM 2. 11 445837 A1261700 Hs. 145544 ESTs TM 2. 11 423880 BE278111 Hs. 134200 DKFZP564C186pr TM 2. 10 421574 AJ000152 Hs. 105924 defensin, beta Defensin beta, TM, SS 2. 10 437103 AW139408 Hs. 152940 ESTs Choline kise, TM, 2. 10 450747 A1064821 Hs. 48306 ESTs, Highlysi mm, TM, 2. 10 437033 AW248364 Hs. 5409 RNA polymerase TM 2. 10 417640 D30857 Hs. 82353 protein C recep TM, SS 2. 10 2. 10 431120 AA492588 gb : ng99cO8. sl N TM, SS 2. 10 430510 AW162916 Hs. 241576 hypothetical pr TM 2. 10 429669 BE185499 Hs. 2471 KIAA0020 gene p TM 2. 10 407881 AW072003 Hs. 40968 heparan sulfate SS 2. 10 436415 BE265254 Hs. 5181 proliferation-a Peptidase M24, TM, SS 2. 10 407887 AA579668 Hs. 41072 serine (orcysl serpin, TM, 2. 10 447815 A1432199 Hs. 247084 ESTs LIM, TM, 2. 09 434274 AA628539 Hs. 116252 ESTs, Moderatel nm, TM, SS 2. 09 411571 AA122393 Hs. 70811 hypothetical pr SS 2. 09 442525 AF150282 Hs. 145945 ESTs pkise, TM, 2. 09 423750 AF165883 Hs. 132415 prefoldin 2 TM 2. 09 449199 A1990122 Hs. 196988 ESTs ras, TM, 2. 09 415363 Api670947 Hs. 78406 phosphatidylino PIPSK, pkise, TM, SS 2. 09 418462 BE001596 Hs. 85266 integrin, beta integrin_B, fn3, TM, SS 2. 09 430335 D80007 Hs. 239499 KIAA0185 protei S1, TM, 2. 08 443450 N66045 Hs. 133529 ESTs TM 2. 08 418753 BE217818 Hs. 87016 Homo sapiens cD TM 2. 08 439018 AW300887 Hs. 26638 ESTs, Weakly si TM, SS 2. 08 431628 AF146277 Hs. 265561 CD2-associated SH3, SS 2. 08 446528 AU076640 Hs. 15243 nucleolar prote Noll_Nop2_Sun, TM, 2. 08 411372 Al147861 Hs. 213289 lowdensiblip EGF, ldl_recepl_a, ldl_recept_b, TM, SS 2. 08 459319 NM 000059 gb : Homo sapiens BRCA2_repeal, TM, 2. 08 408730 AV660717 Hs. 47144 DKFZP586N0819 p TM, SS 2. 08 409220 BE243323 Hs. 51233 {umornecrosis TNFR c6death, TM, 2. 08 429504 X99133 Hs. 204238 lipocalin 2 (on lipocaiin, SS 2. 08 409686 AK000002 Hs. 55879 Homo sapiens mR ABC tran, ABC_membrane, TM, 2. 08 413092 AA126856 Hs. 118665 ESTs EGF, TM, SS 2. 08 413715 AW851121 Hs. 75497 Homo sapiens cD cyclin, TM, 2. 08 423020 AA383092 Hs. 1608 replication pro TM 2. 07 438378 AW970529 Hs. 86434 Homo sapiens cD TM, SS 2. 07 432125 AW972667 Hs. 287510 HomosapienscD Band_41, TM, SS 2. 07 449370 AK002114 Hs. 23495 hypothetical pr TM. SS 2. 07 454011 M31008 Hs. 37009 alkaline phosph alk_phosphatase, TM, SS 2. 07 427876 A1494291 Hs. 111977 ESTs TM 2. 07 422901 R81936 Hs. 121576 aspartatebeta-SS 2. 07 449207 AL044222 Hs. 23255 nucleoporin 155 TM, SS 2. 07 408243 Y00787 Hs. 624 intedeukin 8 IL8, TM, SS 2. 07 446546 BE167687 Hs. 156628 ESTs Sulfotransfer, TM, SS 2. 07 423472 AF041260 Hs. 129057 breastcarcinom TM 2. 07 436211 AK001581 Hs. 80961 polymerase (DNA TM 2. 07 456157 AW979153 gb : EST391263 MA transmembrane4, TM, 2. 06 407143 C14076 Hs. 248968 EST TM 2. 06 432440 X63597 Hs. 2996 sucrase-isomatt Glyco_hydro_31, trefoil, TM, SS 2. 06 410668 BE379794 Hs. 65403 hypothetical pr TM 2. 06 422765 AW409701 Hs. 1578 baculoviraIlAP BIR, TM, 2. 06 439832 T81829 Hs. 14870 ESTs SS 2. 06 445318 AW500652 Hs. 200885 ESTs TM 2. 06 439951 A1347067 Hs. 124636 ESTs TM, SS 2. 06 428307 W27393 Hs. 183648 protein tyrosin TM 2. 06 432584 AA928829 Hs. 47099 Homo sapiens cD SS 2. 06 433027 AF191018 Hs. 279923 putative nucleo MMR_HSR1, TM, 2. 06 433716 AA608808 Hs. 225118 ESTs TM 2. 06 429412 NM 006235 Hs. 2407 POU domain, da TM 2. 06 449026 BE500946 Hs. 209105 ESTs TM 2. 06 437016 AU076916 Hs. 5398 guanine monphos GATae, GMP_synt_C, TM, 2. 06 442547 AA306997 Hs. 268362 ESTs, Weakly si SS 2. 06 455778 BE088746 gb : CM2-BT0693-2 TM 2. 06 439975 AW328081 Hs. 6817 Homo sapiens pu TM, SS 2. 06 433037 NM 014158 Hs. 279938 HSPC067 protein TM 2. 06 440086 NM005402 Hs. 288757 v-ral simian le ra, TM, 2. 06 436414 BE264633 Hs. 143638 WDrepeatdomai WD40, TM, 2. 05 411770 NM_014278 Hs. 71992 heat shock prot HSP70, TM, 2. 05 409459 D86407 Hs. 54481 low density lip EGF, IdI_recept a, ldl_recept_b, TM, SS 2. 05 436238 AK002163 Hs. 301724 ESTs, Highly si MMR_HSR1, TM, 2. 05 400517 AF242388 Hs. 149585 lengsin TM 2. 05 421904 BE143533 Hs. 109309 hypothetical pr SS 2. 05 417850 AA215724 Hs. 82741 primae, polype SS 2. 05 417491 AW376842 Hs. 1085 guanylaecycla pkise, guanylate_cyc, ANF receptor, TM, SS 2. 05 453775 NM002916 Hs. 35120 replication fac AAA. TM, SS 2. 05 435525 A1831297 Hs. 123310 ESTs TM 2. 05

412627 BE391959 Hs. 74276 chlondeinirac Gpatch, ig, MulS C, TM, 2. 05 439702 AW085525 Hs. 134182 ESTs A2M, SS 2. 05 440006 AK000517 Hs. 6844 hypothetical pr TM 2. 05 417308 H60720 Hs. 81892 KIAA0101 gene p TM 2. 05 446311 AW007294 Hs. 149795 ESTs. Weakly si pkise, TM, 2. 05 427871 AW992405 Hs. 59622 ESTs, Weakly si SS 2. 05 453804 AA300204 Hs. 35276 KIAA0852 protei TM, SS 2. 05 449939 T86420 Hs. 272139 ESTs DIL, myosin_head, TM, SS 2. 05 417819 Api253112 Hs. 133540 ESTs TM 2. 04 427747 AW411425 Hs. 180655 senne/threonin pkise, TM, 2. 04 415009 C75253 Hs. 220950 ESTs TM 2. 04 437829 Al358522 Hs. 270188 ESTs TM 2. 04 428753 AW939252 Hs. 192927 hypothetical pr TM 2. 04 446475 AI908188 Hs. 209245 ESTs OPR, TM, 2. 04 431394 AK000692 Hs. 252351 HERV-H LTR-asso ig, TM, SS 2. 04 423701 AA329856 Hs. 143022 ESTs TM 2. 04 422369 AF005216 Hs. 115541 Janus kinase 2 SH2, pkise, TM, 2. 04 432481 AW451645 Hs. 151504 Homo sapiens cD TSPN, Collagen, TM, SS 2. 04 443746 AW861379 Hs. 160602 ESTs TM 2. 04 400792 AA635062 Hs. 50094 Homo sapiens mR zf-C3HC4, CARD, BIR, TM, 2. 04 428343 AL043021 Hs. 12705 ESTs, Weakly si TM 2. 04 419329 AY007220 Hs. 288998 S100-type calci TM 2. 04 403485 filamntTM, 2. 04 413313 NM 002047 Hs. 75280 glycyl-tRNAsyn WHEP-TRS, 7tm_2, TM, SS 2. 04 433326 A1379486 Hs. 159430 ESTs TM 2. 03 440246 W52010 Hs. 191379 ESTs serpin, TM, 2. 03 444006 BE395085 Hs. 10086 type I transmem TM, SS 2. 03 452705 H49805 Hs. 246005 ESTs TM 2. 03 421724 AB037832 Hs. 107287 KIAA1411 protei TM 2. 03 447474 AW614220 Hs. 189402 ESTs SS 2. 03 418852 BE537037 Hs. 273294 hypothetical pr TM 2. 03 431842 NM005764 Hs. 271473 epithelial prol TM, SS 2. 03 440773 AA352702 Hs. 37747 hypothetical pr TM 2. 03 443425 A1056776 Hs. 133397 ESTs TM, SS 2. 03 407975 X89426 Hs. 41716 endothelial cel IGFBP, SS 2. 03 428299 AL038004 Hs. 29419 ESTs TM, SS 2. 03 415757 AA830854 Hs. 187810 ESTs TM 2. 03 432559 AW452948 Hs. 257631 ESTs PAC, TM, SS 2. 03 425912 AL137629 Hs. 162189 sedne/threonin fn3, ig, PH, RhoGEF, TM, SS 2. 02 419395 BE268326 Hs. 90280 5-aminoimidazol AlCARFT_IMPCHas, MGS, TM, 2. 02 417576 AA339449 Hs. 82285 phosphoribosylg AIRS, formyl_transf, GARS, TM, 2. 02 418559 AA225048 Hs. 104207 ESTs TM 2. 02 410855 X97795 Hs. 66718 RAD54 (S. cerevi SNF2_N, helicase_C, TM, 2. 02 422072 A8018255 Hs. 111138 KIAA0712 gene p TM 2. 02 419546 AA244199 gb : ncO6cO5. sl N Y-phosphatase, TM, 2. 02 450516 AA902656 Hs. 21943 NIF3 (Ngg1 inte DUF34, TM, 2. 02 419807 R77402 gb : yi75f11. s1S TM 2. 02 438192 Api859065 Hs. 16808 ESTs, Weakly si TM, SS 2. 02 401866 filament, TM, SS 2. 02 443129 R16075 Hs. 21668 ESTs TM, SS 2. 02 424783 AA913909 Hs. 153088 TATA box bindin TM 2. 01 413293 AL047483 Hs. 75270 GTP-binding pro ras, TM, SS 2. 01 435787 AW162767 Hs. 100914 hypotheUcalpr SS 201 422599 BE387202 Hs. 118638 non-metastatic NDK, SS 2. 01 431630 NM 002204 Hs. 265829 integrin, alpha FGGAP, integnn_A, TM, SS 2. 01 448275 BE514434 Hs. 20830 synaptic Ras GT kinesin, PHD, abhydrolase_2, TM, SS 2. 01 405484 filament, SS 2. 01 436469 AK001455 Hs. 5198 Down syndrome c TM 2. 01 451273 NM_014811 Hs. 26163 KIAA0649 gene p TM 2. 01 432378 Api493046 Hs. 146133 ESTs TM 2. 01 419981 AA897581 Hs. 128773 ESTs Skin. SS 2. 01 445808 AV655234 Hs. 298083 ESTs sushi, TM, SS 2. 01 435767 H73505 Hs. 117874 ESTs PeptidaseS8. P, TM, 2. 01 430466 AF052573 Hs. 241517 polymerase (DNA TM 2. 01 422790 AA809875 Hs. 25933 ESTs TM 2. 01 443303 U67319 Hs. 9216 capae 7, apop ICE_p10, 1CE*D20, TM, 2. 01 410008 AA079552 gb : zm20h12. s1 S FG-GAP. TM, SS 2. 01 440774 Api420611 Hs. 127832 ESTs zf-MYND, TM, SS 2. 00 442961 BE614474 Hs. 289074 Homo sapiens cD TM 2. 00 424420 BE614743 Hs. 146688 prostaglandin E MAPEG, TM, SS 2. 00 410240 AL157424 Hs. 61289 synaptojanin 2 TM 2. 00 435014 BE560898 Hs. 10026 ribosomal prote Ribosoma_L17, TM, 2. 00 406752 Api285598 Hs. 217493 annexinA2 TM 2. 00 TABLE 41B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 410008 1168121 M079552 BE142525 BE142527 418546 1766771 AA224827 T59708 T59843 BE156903 419546 185766_1 AA244199 AA244272 H57440

419807 188252 1 R77402 AA262462 AA250988 R06794 422689 219896 1 AW856665M315006AW954733 431120 328264 1 AA492588 AA492498 AA492571 433748 37385 1 R12244 H71290 A1110858 AF090916 AF075357 AA011531 438223 452646 1 AA781171 A1202139 A1202098 438993 46765111 AA828995 AA834879 A1926361 446995 702707 1 A1355012 AW812856 447197 711623 1 R36075 A1366546 R36167 450190 827655_1 T51387AW191595T51271AI686285 451237 863269_1 AW600293AI767468 455778 1364506_1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 456157 158261_1 AW979153 AA176967 AA826015 TABLE 41C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entiUed'The DNA sequence of human chromosome 22'Dunham. et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 400514 9796594 Minus 78844-79025, 80850-80991, 89754-89941, 93750-93891 401519 6649315 Plus 157315-157950 401708 2951946 Plus 154511-155298 401866 8018106 Plus 73126-73623 402075 8117407 Pfus 121907-122035. 122804-122921, 124019-124161, 124455-124610, 125672-126076 403055 8748904 Minus 109532-110225 403208 7630829 Minus 147706-147903, 148667-148804 403422 9665041 Minus 151169-151561 403485 9966528 Plus 2888-3001. 319&3532, 3655-4117 403776 7770611 Minus 1414-1513, 1624-1756 404171 9930793 Plus 173667-173783, 176876-177055 404253 9367202 Minus 55675-56055 404519 8152000 Plus 12817-13000 404567 7249169 Minus 101320-101501 405484 5922025 Plus 199214-199579, 199672-199920, 200262-200495 405545 1054740 Plus 118677-118807, 119091-119296. 121626-121823 405818 4071056 Plus 29055-29196 406399 9256288 Minus 63448-63554 TABLE 42A : ABOUT 561 GENES UP-REGULATED IN STOMACH CANCER Table 42A lists about 561 genes up-regulated in stomach cancer compared to normal stomach. These were selected as for Table 40A except using various non-malignant stomach specimens in determining the denominator value. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of tumor to normal tissue Pkey ExAccn UnigenelD Unigene Title RI 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin 60. 4 448693 AW004854 Hs. 228320 Homo sapiens cDNA : FLJ23537 fis, clone L 28. 6 428664 AK001666 Hs. 189095 similartoSALL1 (sal (Drosophila)-like 26. 8 422330 D30783 Hs. 115263 epiregulin 22. 0 415989 A1267700 Hs. 111128 ESTs 21. 2 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 19. 0 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 17. 1 403776 14. 9 424905 NM 002497 Hs. 153704 NIMA (never in mitosis gene a)-related k 14. 8 414132 A1801235 Hs. 48480 ESTs 14. 2 450375 AA009647 Hs. 8850 a disintegnn and metaloproteinae doma 14 0 453922 AF053306 Hs. 36708 budding uninhibited by benzimidazoles 1 13. 8 436032 AA150797 Hs. 109276 latexin protein 13. 1 427585 D31152 Hs. 179729 collagen, type X, alpha 1 (Schmid metaph 12. 5 416661 AA634543 Hs. 79440 IGF-II mRNA-binding protein 3 12. 2 414972 BE263782 Hs. 77695 KIAA0008 gene product 10. 6 445900 AF070526 Hs. 13429 Homo sapiens clone 24787 mRNA sequence 10. 5 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteopon6n, 10. 5 441377 BE218239 Hs. 202656 ESTs 10. 2 419423 D26488 Hs. 90315 KIAA0007 protein 9. 8 415138 C18356 Hs. 78045 tissue factor pathway inhibitor 2 9. 6 424639 A1917494 Hs. 131329 ESTs 9. 4 412472 AW975398 Hs. 293836 ESTs 9. 2 447048 AW393080 Hs. 228320 Homo sapiens cDNA : FLJ23537 fis, clone L 8. 9 418379 AA218940 Hs. 137516 fidgetin-like 1 8. 8 423020 AA383092 Hs. 1608 replication protein A3 (14kD) 8. 6 408908 BE296227 Hs. 48915 serine/threonine kinase 15 8. 5 419948 AB041035 Hs. 93847 NADPHoxidase4 83 411750 BE562298 Hs. 71827 KIAA0112 protein ; homolog of yeast ribos 8. 3 411479 AW848047 gb : IL3-CT0214-291299-052-A12 CT0214 Homo 8. 1 420900 AL045633 Hs. 44269 ESTs 8. 0 449347 AV649748 Hs. 295901 ESTs 8. 0

409041 AB033025 Hs. 50081 K1AA1199 protein 8. 0 450480 X82125 Hs. 25040 zinc finger protein 239 7. 6 417655 AA780791 Hs. 14014 ESTs, Weakly similar to KIAA0973 protein 7. 6 453878 AW964440 Hs. 19025 ESTs 7. 6 430403 AF039390 Hs. 241382 tumor necrosis factor (ligand) superfami 7. 5 427961 AW293165 Hs. 143134 ESTs 7. 4 428330 L22524 Hs. 2256 matrix metalloproteinae 7 (matri) ysin. 7. 3 426235 A1631964 Hs. 34447 ESTs 7. 1 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7, S. cerevisi 7. 0 418205 L21715 Hs. 83760 troponinl, skeletal, fast 7. 0 409757 NM 001898 Hs. 123114 cystatin SN 6. 9 430044 AA464510 Hs. 152812 ESTs 6. 6 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homologj, act 6. 5 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h 6. 5 449020 A1621170 Hs. 192699 ESTs 6. 3 431958 X63629 Hs. 2877 cadherin 3, lype 1, P-cadherin (placenta 5. 8 434699 AA643687 Hs. 149425 Homo sapiens cDNA FLJ11980 fis, clone HE 5. 7 424345 AK001380 Hs. 145479 Homo sapiens cDNA FW10518 hs, done NT 5. 6 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 5. 4 434551 BE387162 Hs. 280858 ESTs, Highly similar to XPBHUMANDNA-RE 5. 3 427660 A1741320 Hs. 114121 Homo sapiens cDNA : FLJ23228 fis, clone C 5. 0 424960 BE245380 Hs. 153952 S nucleoGdase (CD73) 4. 9 400268 4. 8 408427 AW194270 Hs. 177236 ESTs 4. 7 453785 A1368236 Hs. 283732 ESTs 4. 7 411274 NM 002776 Hs. 69423 kallikrein 10 4. 7 424717 H03754 Hs. 152213 wingless-type MMTV integration site fami 4. 7 415752 BE314524 Hs. 78776 putative transmembrane protein 4. 6 434370 AF130988 Hs. 58346 downless (mouse) homolog 4. 6 431806 AF186114 Hs. 270737 tumornecrosisfactor (ligand) superfami 4. 6 400205 4. 6 422938 NM 001809 Hs. 1594 centromere protein A (17kD) 4. 5 406687 M31126 Hs. 272620 pregnancy specific betal-glycoprotein 9 4. 4 453160 A1263307 Hs. 146228 ESTs 4. 4 423871 AA331906 gb : EST35805 Embryo, 8 week I Homo sapien 4. 4 431211 M86849 Hs. 5566 gap junction protein, beta 2, 26kD (conn 4. 4 446638 AL133063 Hs. 15783 HomosapiensmRNA ; cDNADKFZp434P1115 (f 4. 3 406741 AA058357 Hs. 74466 carcinoembryonic antigen-related cell ad 4. 3 411560 AW851186 gb : L3-CT0220-150200-071-H05CT0220Homo 4. 1 433159 AB035898 Hs. 150587 kinesin-like protein 2 4. 1 446142 Api754693 Hs. 145968 ESTs 4. 1 414727 BE466904 gb : hz28fO3. xl NCI CGAP GC6Homosapiens 4. 1 422285 Al803103 gb : tc14e06. xl Soares_NhHMPu_S1 Homosapi 4. 1 451807 W52854 Hs. 27099 DKFZP564J0863 protein 4. 1 411558 AA102670 Hs. 70725 gamma-aminobutyricacid (GABA) A recepto 4. 0 415701 NM 003878 Hs. 78619 gamma-glutamyl hydrolase (conjugae, fol 4. 0 409420 Z15008 Hs. 54451 laminin, gamma 2 (nicein (lOOkD), ka) inti 3. 9 452909 NM015368 Hs. 30985 pannexin 1 3. 9 443211 A1128388 Hs. 143655 ESTs 3. 9 442896 R37725 Hs. 261108 ESTs 3. 8 407788 BE514982 Hs. 38991 S100 calcium-binding protein A2 3. 8 406671 AA129547 Hs. 285754 met proto-oncogene (hepatocyte growth fa 3. 8 421155 H87879 Hs. 102267 lysyl oxidase 3. 8 420552 AK000492 Hs. 98806 hypothetical protein 3. 8 420727 H75701 Hs. 99886 complement component 4-binding protein, 3. 7 422665 AJ011812 Hs. 119018 transcdpbon factor NRF 3. 7 447425 A1963747 Hs. 18573 acylphosphatase 1, erythrocyte (common) 3. 7 417715 AW969587 Hs. 86366 ESTs 3. 7 406076 AL390179 Hs. 137011 HomosapiensmRNA ; cDNADKFZp547P134 (fr 3. 6 452281 T93500 Hs. 28792 Homo sapiens CDNA FU 11041 fis, clone PL 3. 6 412723 AA648459 Hs. 179912 ESTs 3. 6 452461 N78223 Hs. 108106 transcription factor 3. 6 453331 A1240665 Hs. 8895 ESTs 3. 6 406434 3. 6 417956 AA210704 Hs. 190465 ESTs 3. 6 410102 AW248508 Hs. 279727 Homo sapiens cDNA FW 14035 fis, clone HE 3. 6 426471 M22440 Hs. 170009 transforming growth factor, alpha 3. 5 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 3. 5 442556 AL137761 Hs. 8379 Homo sapiens mRNA ; cDNA DKFZp586L2424 (f 3. 5 426957 Axa393676 Hs. 97459 ESTs, Weakly similar to KIAA0819 protein 3. 5 448105 AW591433 Hs. 170675 ESTs, WeaklysimilartoTMS2_HUMANTRANS 3. 5 414998 NM002543 Hs. 77729 oxidised low density lipoprotein (lectin 3. 5 442942 AW167087 Hs. 131562 ESTs 3. 4 416391 Al878927 Hs. 79284 mesoderm specific transcript (mouse) hom 3. 4 420230 AL034344 Hs. 298020 Homo sapiens cDNA FLJ 11796 fis, clone HE 3. 4 408243 Y00787 Hs. 624 interleukin 8 3. 4 412978 A1431708 Hs. 820 homeo box C6 3. 4 412851 A1826502 Hs. 106149 ESTs 3. 4 417720 AA205625 Hs. 208067 ESTs 3. 4 414812 X72755 Hs. 77367 monokine induced by gamma interferon 3. 4 453884 AA355925 Hs. 36232 KIAA0186 gene product 3. 4 436396 A1683487 Hs. 299112 Homo sapiens cDNAFU 11441 (is. done HE 3. 4 425921 NM007231 Hs. 162211 sotutecamer family 6 (neurotransmitte 3. 4

420092 AA814043 Hs. 88045 ESTs 3. 3 423441 R68649 Hs. 278359 absent in melanoma 1 like 3. 3 421787 AA227068 Hs. 108301 nuclear receptor subfamily 2, group C, m 3. 3 447342 A1199268 Hs. 19322 ESTs 3. 3 430178 AW449612 Hs. 152475 ESTs 3. 3 452826 BE245286 Hs. 301636 ESTs, Moderately similar to PEX6 HUMAN P 3. 3 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 3. 3 413339 A1818080 Hs. 194290 ESTs 3. 3 448756 A1739241 Hs. 171480 ESTs 3. 3 421948 L42583 Hs. 111758 keratin 6A 3. 3 431453 AW753917 gb : RCO-CT0299-291199-031-F02CT0299Homo 3. 3 438538 AA832203 Hs. 291955 ESTs 3. 3 439759 AL359055 Hs. 67709 Homo sapiens mRNA hull length insert cDN 3. 3 431721 AB032996 Hs. 268044 KJAA1170 protein 3. 3 436391 AJ227892 Hs. 146274 ESTs 3. 3 442025 AW887434 Hs. 11810 ESTs, Weakly similar to CD4. 2 [C. elegans 3. 3 418007 M13509 Hs. 83169 matrix metalloproteinase 1 (intersbfial 3. 2 411678 Api907114 Hs. 71465 squalene epoxidase 3. 2 422956 BE545072 Hs. 122579 hypothetical protein FU10461 3. 2 450400 A1694722 Hs. 279744 ESTs 3. 2 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 3. 2 423528 AB011137 Hs. 129740 KIM0565 gene product 3. 2 440659 AF134160 Hs. 7327 claudin 1 3. 2 441085 AW136551 Hs. 181245 Homo sapiens DNA FLJ12532 fis, clone NT 3. 2 412022 A1005043 Hs. 24143 ESTs 3. 2 418203 X54942 Hs. 83758 CDC28 protein kinase 2 3. 1 416111 AA033813 Hs. 79018 chromatinasemblyfætorl, subunitAt 3. 1 408633 AW963372 Hs. 46677 PR02000 protein 3. 1 445808 AV655234 Hs. 298083 ESTs 3. 1 414618 A1204600 Hs. 96978 ESTs 3. 1 421340 F07783 Hs. 1369 decay accelerating factor for complement 3. 1 422689 AW856665 gb : RC3-CT0297-290100-013-d03 CT0297 Homo 3. 1 456508 AA502764 Hs. 123469 ESTs, Weakly similar to AF2088551 BM-01 3. 1 420759 T11832 Hs. 127797 ESTs 3. 1 452637 AW971231 Hs. 291020 ESTs 3. 1 415857 AA866115 Hs. 301646 Homo sapiens cDNA FLJ11381 fis, clone HE 3. 1 439451 AF086270 Hs. 278554 heterochromaUn-like protein 1 3. 1 424051 AL110203 Hs. 138411 Homo sapiens mRNA ; cDNA DKFZp586J1922 (f 3. 1 440138 AB033023 Hs. 6982 hypothetical protein FU10201 3. 1 454456 AW850984 gb : IL3-CT0220-150200-068-H08 CT0220 Homo 3. 0 429125 AA446854 Hs. 271004 ESTs 3. 0 408031 AA081395 Hs. 42173 Homo sapiens cDNA FW 10366 hs, clone NT 3. 0 438394 BE379623 Hs. 27693 CGI-124 protein 3. 0 409361 NM005982 Hs. 54416 sine oculis homeobox (Drosophila) homolo 3. 0 439453 BE264974 Hs. 6566 thyroid hormone receptor interactor 13 3. 0 414696 AF002020 Hs. 76918 Niemann-Pickdiseae, WpeC1 3. 0 422746 NM004484 Hs. 119651 glypican3 3. 0 424947 R77952 Hs. 239625 integral membrane protein 2B 3. 0 453775 NM002916 Hs. 35120 replicabonfætorC (æUvator1) 4 (37 3. 0 449386 AA001308 Hs. 193213 ESTs 3. 0 430687 BE274217 Hs. 249247 heterogeneous nuclear protein similar to 2. 9 428862 NM000346 Hs. 2316 SRY (sex-determining region Yybox 9 (ca 2. 9 401747 2. 9 429682 NM6306 Hs. 211602 SMC1 (structural maintenance of chromoso 2. 9 444735 BE019923 Hs. 243122 hypothetical protein FLJ13057 similar to 2. 9 413385 M34455 Hs. 840 indoleamine-pyrrole 2, 3 dioxygenase 2. 9 436222 A1208737 Hs. 122810 Homo sapiens cDNA FLJ 11489 fis, clone HE 2. 9 442961 BE614474 Hs. 289074 Homo sapiens cDNA 13986fis. done Y7 2. 9 454798 AW821295 gb : PM3-ST0307-241299-002-gO3 ST0307 Homo 2. 9 421650 AA781795 Hs. 122587 ESTs 2. 9 434398 AA121098 Hs. 3838 serum-inducible kinase 2. 9 420153 N22120 Hs. 75277 hypothetical protein FLJ13910 2. 9 435706 W31254 Hs. 7045 GL004 protein 2. 9 416065 BE267931 Hs. 78996 proliferating cell nuclear antigen 2. 9 423250 BE061916 Hs. 125849 chromosome 8 open reading frame 2 2. 8 423493 AI815965 Hs. 129683 ubiquitinconjugating enzyme E2D1 (homo 2. 8 430242 U66669 Hs. 236642 3-hydroxyisobutyryl-Coenzyme A hydrolase 2. 8 436411 AW674352 gb : baS3cO7. yl NlH_MGC_12HomosapienscD 2. 8 411770 NM_014278 Hs. 71992 heat shock protein (hspl 10 family) 2. 8 437834 AA769294 gb : nz36g03. s1 NCI_CGAP_GCB1 Homosapiens 2. 8 400440 X83957 Hs. 83870 nebulin 2. 8 444743 AA045648 Hs. 11817 nudix (nucleosidediphosphatelinkedmoi 2. 8 428725 A1565937 Hs. 98692 ESTs 2. 8 417771 AA804698 Hs. 82547 retinoic acid receptor responder (tazaro 2. 8 449420 A1654852 Hs. 196562 ESTs, Highly similar to TS24 MOUSE PROTE 2. 8 433929 A1375499 Hs. 27379 ESTs 2. 8 430287 AW182459 Hs. 125759 ESTs, Weakly similar to tumor suppressor 2. 8 423346 A1267677 Hs. 127416 synaptojanin 1 2. 8 407824 AA147884 Hs. 9812 ESTs 2. 8 408482 NM 000676 Hs. 45743 adenosine A2b receptor 2. 8 425188 AK002052 Hs. 155071 hypotheticalproteinFW11190 2. 8 456999 AA319798 Hs. 172247 eukaryotic translation elongation factor 2. 8 408875 NM 015434 Hs. 48604 DKFZP434B168 protein 2. 8

407839 AA045144 Hs. 161566 ESTs 2. 7 409012 AL117435 Hs. 49725 DKFZP4341216 protein 2. 7 410762 AF226053 Hs. 66170 HSKM-Bprotein 2. 7 426925 NM 001196 Hs. 172894 BH3 interacting domain death agonist 2. 7 410116 AW630671 Hs. 58636 squamouscellcancinomaanUgenrecogniz 2. 7 428398 A1249368 Hs. 98558 ESTs 2. 7 400048 AFFX controi : YEL002c/WBP1 2. 7 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 2. 7 435664 A1032087 Hs. 269819 ESTs 2. 7 405695 2. 7 456655 Api376736 Hs. 111779 secreted protein, acidic, cysteine-rich 2. 7 408670 AF160967 Hs. 46784 potassium large conductance caidum-acti 2. 7 422576 BE548555 Hs. 118554 CGI-83 protein 2. 7 431379 AA504264 Hs. 182937 peptidylprolyl isomerase A (cyclophilin 2. 7 429540 M85776 gb : EST02297 Fetal brain, Stratagene (cat 2. 7 426874 N67325 Hs. 247132 ESTs 2. 7 433183 AF231338 Hs. 222024 transcripúonfxtorBMAL2 Z7 409902 A1337658 Hs. 156351 ESTs 2. 7 422336 AI761322 Hs. 115285 dihydrolipoamide S-acetyltransferase (E2 2. 7 408434 AW195317 Hs. 107716 HomosapienscDNA : FLJ22344 fis, done H 2. 7 432328 AI572739 Hs. 195471 6-phosphofructo-2-kinase/fructose-2, 6-bi 2. 7 407633 NM007069 Hs. 37189 similar to rat HREV107 2. 6 419216 AU076718 Hs. 164021 sma'l inducibie cytokine subfamily B (Cy 2. 6 422363 T55979 Hs. 115474 replication factor C (activator ) 3 (38 Z6 445564 AB028957 Hs. 12896 KIAA1034 protein 2. 6 401644 2. 6 417479 A1057052 Hs. 133554 ESTs 2. 6 434217 AW014795 Hs. 23349 ESTs 2. 6 426514 BE616633 Hs. 301122 bone morphogenetic protein 7 (osteogenic 2. 6 414800 BE538690 gb : 601064676FlNIH MGC_lOHomosapiensc 2. 6 400289 X07820 Hs. 2258 matrix metalloproteinase 10 (stromelysin 2. 6 418478 U38945 Hs. 1174 cyclin-dependent kinase inhibitor 2A (me 2. 6 421246 AW582962 Hs. 300961 ESTs, HighlysimilartoAF151805 1 CGI-4 2. 6 430397 Api924533 Hs. 105607 ESTs 2. 6 428048 AA705745 Hs. 185070 ESTs 2. 6 452092 BE245374 Hs. 27842 hypothetical protein FLJ11210 2. 6 440052 A1633744 Hs. 195648 ESTs 2. 6 433077 AA314262 Hs. 289008 Homo sapiens cDNA : FLJ21814 fis, clone H 2. 6 432407 AA221036 Hs. 285026 HERV-H LTR-associating 1 2. 6 452401 Nom-007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 2. 6 451813 Nom016117 Hs. 27182 phospholipaeA2-æUvaUngprotein 2. 6 410889 X91662 Hs. 66744 twist (Drosophila) homolog (acrocephalos 2. 6 440100 BE382685 Hs. 158549 ESTs 2. 6 413746 AA133243 Hs. 171553 ESTs 2. 6 414737 A1160386 Hs. 125087 ESTs 2. 6 422063 BE156476 gb : QVO-HT0368-040100-082-c05 HT0368 Homo 2. 6 418250 U29926 Hs. 83918 adenosine monophosphate deaminase (isofo 2. 6 437641 AA811452 Hs. 291911 ESTs 2. 6 436027 A1864053 Hs. 39972 ESTs, Weakly similar to 138588 reverse t 2. 6 444381 BE387335 Hs. 283713 ESTs. Weakly similar to CA54 HUMAN COLLA 2. 6 452571 W31518 Hs. 34665 ESTs 2. 6 452862 AW378065 Hs. 8687 ESTs 2. 6 411984 NM 005419 Hs. 72988 signal transducer and activator of trans 2. 6 446440 AV658411 Hs. 42656 Homo sapiens cDNA FU12667 fis, clone NT 2. 6 448663 BE614599 Hs. 106823 H. sapiens gene from PAC 42616, similar t 2. 6 426427 M86699 Hs. 169840 TTK protein kinase 2. 6 445848 AA774824 Hs. 13377 Homo sapiens clone 23649 and 23755 unkno 2. 6 420022 AA256253 Hs. 120817 ESTs 2. 6 451418 BE387790 Hs. 26369 hypothetical protein FW20287 2. 6 428953 AA306610 Hs. 194676 DKFZP434C013 protein 2. 6 424008 R02740 Hs. 137555 putative chemokine receptor : GTP-binding 2. 6 417863 AB000450 Hs. 82771 vaccinia related kinase 2 2. 6 414987 AA524394 Hs. 165544 ESTs 2. 6 440249 A1246590 Hs. 125325 ESTs 2. 6 407966 AA295052 Hs. 38516 ESTs 2. 5 406685 M18728 gb : Human nonspecific crossreacting antig 25 403204 2. 5 436961 AW375974 Hs. 156704 ESTs 2. 5 422260 AA315993 Hs. 105484 ESTs, WeaklysimilartoLITB_HUMANLITHO 2. 5 444471 AB020684 Hs. 11217 KIAA0877 protein 2. 5 430290 A1734110 Hs. 136355 ESTs 2. 5 413670 AB000115 Hs. 75470 hypothetical protein, expressed in osteo 2. 5 421928 AF013758 Hs. 109643 polyadenylale binding protein-interactin 2. 5 439580 AF086401 Hs. 293847 ESTs 2. 5 439963 AW247529 Hs. 6793 platelet-acfivafing factor acethydrola 2. 5 457065 A) 476318 Hs. 192480 ESTs 2. 5 439521 A1808955 Hs. 58248 ESTs 2. 5 426711 AA383471 Hs. 180669 conserved gene amplified in osteosarcoma 2. 5 422631 BE218919 Hs. 118793 hypotheUcaproteinFW10688 2. 5 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 2. 5 416975 NM004131 Hs. 1051 granzyme B (granzyme 2, cytotoxic T-lymp 2. 5 415947 U04045 Hs. 78934 mutS (E. coli) homolog 2 (colon cancer, 2. 5 454678 AW813089 gb : RC3-ST0186-240400-111-b05ST0186Homo 2. 5

424080 AW189983 Hs. 139119 Homo sapiens cDNA 10967fis. done PL 2. 5 426572 AB037783 Hs. 170623 hypotheúca protein FW11183 Z5 440594 AW445167 Hs. 126036 ESTs 2. 5 428264 AA424839 Hs. 98484 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 5 408750 BE294069 Hs. 93581 hypothetical protein FU10512 2. 5 451177 A1969716 Hs. 13034 ESTs 2. 5 449318 AW236021 Hs. 108788 ESTs, Weakly similar to zeste (D. melanog 2. 5 434414 Api798376 gb : tr34b07. x1 CGAP Ov23Homosapiens 2. 5 400240 2. 5 410519 AW612264 Hs. 131705 ESTs 2. 5 440953 A1683036 Hs. 124135 KIAA1618 protein 2. 5 421190 U95031 Hs. 102482 mucin 5, subtype B, tracheobronchial 2. 5 444478 W07318 Hs. 240 M-phase phosphoprotein 1 2. 5 442295 AI827248 Hs. 224398 HbmosapienscDNAFW11469hs, cloneHE 2, 5 420894 AA744597 Hs. 88854 ESTs 2. 5 410094 BE147897 Hs. 58593 general transcription factor IIF, polype 2. 4 413998 AW103807 Hs. 243933 ESTs 2. 4 412281 Al810054 Hs. 14119 ESTs 2. 4 418105 AW937488 Hs. 178000 ESTs 2. 4 447335 BE617695 Hs. 286192 protein phosphatase l, regulatory (inhib 2. 4 446852 AW451643 Hs. 257479 ESTs, WeadysimilartoAF1477471BOG25 2. 4 408915 NM_016651 Hs. 48950 heptacellular carcinoma novel gene-3 pro 2. 4 442991 BE281238 Hs. 8886 hypothetical protein FU20424 2. 4 410193 AJ132592 Hs. 59757 zinc finger protein 281 2. 4 410664 NM_006033 Hs. 65370 lipase, endothelial 2. 4 449264 A1637649 Hs. 196105 ESTs 2. 4 423453 AW450737 Hs. 128791 CGI-09 protein 2. 4 433757 Al949974 Hs. 152670 ESTs 2. 4 411598 BE336654 Hs. 70937 H3 histone family, member K 2. 4 431657 Api345227 Hs. 105448 ESTs, Weakly similar to B34087 hypothefi 2. 4 429663 M68874 Hs. 211587 phospholipase A2, group IVA (cytosolic, 2. 4 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 2. 4 419559 Y07828 Hs. 91096 ring finger protein 2. 4 419839 U24577 Hs. 93304 phospholipase A2, group VII (platelet-ac 2. 4 419713 AW968058 Hs. 92381 nudix (nucleoside diphosphate linked moi 2. 4 413281 AA861271 Hs. 34396 ESTs 2. 4 402819 2. 4 431457 NM012211 Hs. 256297 integrin, alpha 11 2. 4 422564 A1148006 Hs. 222120 ESTs 2. 4 443683 BE241717 Hs. 9676 uncharacterized hypothalamus protein HTO 2. 4 407242 M18728 gb : HumannonspeciEccrossreæUnganúg 2. 4 409235 AA188827 Hs. 7988 ESTs, Weakly similar to endo-alpha-D-man 2. 4 408938 AA059013 Hs. 22607 ESTs 2. 4 422158 L10343 Hs. 112341 protease inhibitor 3. skin-derived (SKAL 2. 4 423217 Nom000094 Hs. 1640 collagen, type Vil, alpha 1 (epidermolys 2. 4 408321 AW405882 Hs. 44205 cortistatin 2. 4 419086 NM000216 Hs. 89591 Kallmann syndrome 1 sequence 2. 4 452945 AW978187 Hs. 31086 HomosapiensmRNAforcytochromeb5. par 2. 4 452234 AW084176 Hs. 223296 ESTs 2. 4 427722 AK000123 Hs. 180479 hypothetical protein FLJ20116 2. 4 430399 A1916284 Hs. 199671 ESTs 2. 4 450737 AW007152 Hs. 203330 ESTs 2. 4 428513 BE220806 Hs. 184697 Homo sapiens clone 23785 mRNA sequence 24 405454 2. 4 422168 AA586894 Hs. 112408 SIOO calcium-binding protein A7 (psodas 2. 3 421462 AF016495 Hs. 104624 aquaporin 9 2. 3 403416 A1744626 Hs. 301506 ESTs, Highly similar to KIAA0564 protein 2. 3 422039 BE567832 Hs. 82148 hypothetical protein 2. 3 448988 Y09763 Hs. 22785 gamma-aminobutyric acid (GABA) A recepto 2. 3 429145 A1694923 Hs. 49031 ESTs 2. 3 423198 M81933 Hs. 1634 cell division cycle 25A 2. 3 442914 AW188551 Hs. 99519 Homo sapiens cDNA FW14007 hs, clone Y7 2. 3 449042 AW294985 Hs. 301148 potassium voltage-gated channel, Isk-rel 2. 3 421308 AA687322 Hs. 192843 ESTs 2. 3 419926 AW900992 Hs. 93796 DKFZP586D2223 protein 2. 3 429992 AL050053 Hs. 227397 Homo sapiens mRNA ; cDNA DKFZp566E103 (fr 2. 3 440601 N62409 Hs. 126688 ESTs 2. 3 446232 A1281848 Hs. 165547 ESTs 2. 3 410174 AA306007 Hs. 59461 DKFZP434C245 protein 2. 3 452110 T47667 Hs. 28005 Homo sapiens mRNA ; cDNA DKFZp564G2463 (f 2. 3 422493 AW474183 Hs. 233816 ESTs 2. 3 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 2. 3 411096 U80034 Hs. 68583 mitochondria) intermediate peptidase 2. 3 426457 AW894667 Hs. 169965 chimerin (chimaerin) 1 2. 3 442029 AW956698 Hs. 14456 neural precursor cell expressed, develop 2. 3 446545 A1431798 Hs. 164192 ESTs, WeahysimilartoY161_HUMANHYPOT 2. 3 422094 AF129535 Hs. 272027 F-box only protein 5 2. 3 421933 R98881 Hs. 109655 sex comb on midleg (Drosophila)-like 1 2. 3 430001 A1580056 Hs. 98992 ESTs 2. 3 420802 U22376 Hs. 1334 v-myb avian myeloblastosis viral oncogen 2. 3 402053 2. 3 415666 H72693 gb : yuO3c11. rl Soaresfetalliverspleen 2. 3 432743 Al146966 Hs. 101656 ESTs 2. 3

433409 A1278802 Hs. 25661 ESTs 2. 3 408330 AW182602 Hs. 249954 ESTs 2. 3 407807 AL031427 Hs. 40094 Human DNA sequence from clone 167A19 on 2. 3 436972 AA284679 Hs. 25640 claudin 3 2. 3 436747 AW977192 Hs. 291343 ESTs 2. 3 433730 AK002135 Hs. 3542 hypothetical protein FU 11273 2. 3 414839 X63692 Hs. 77462 DNA (cytosine-S)-methyltransferae1 2. 3 438192 A1859065 Hs. 16808 ESTs, Weakly similar to paraplegin-like 2. 3 415339 NM015156 Hs. 78398 KIAA0071 protein 2. 3 449539 W80363 Hs. 58446 ESTs 2. 2 412651 AA115333 Hs. 107968 ESTs 2. 2 450956 AW193531 Hs. 205647 ESTs, Moderately similar to AWL-HUMAN A 2. 2 430335 D80007 Hs. 239499 KIAA0185 protein 2. 2 417849 AW291587 Hs. 82733 nidogen 2 2. 2 454946 AW846376 gb : QVO-CT0179-090200-090-f09 CT0179 Homo 2. 2 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 2. 2 408349 BE546947 Hs. 44276 homeo box C10 2. 2 424704 Al263293 Hs. 152096 cytochrome P450, subfamily IIJ (arachido 2. 2 419433 AA814807 Hs. 7395 hypothetical protein FU23182 2. 2 409632 W74001 Hs. 55279 serine (or cysteine) proteinase inhibito 2. 2 415323 BE269352 Hs. 949 neutrophil cytosolicfactor 2 (65kD, chr 2. 2 417531 Nom003157 Hs. 1087 serineAhreoninekinase2 2. 2 403137 2. 2 428479 Y00272 Hs. 184572 cell division cycle 2, G1 to S and G2 to 2. 2 430200 BE613337 Hs. 234896 geminin 2. 2 433745 AF075320 Hs. 28980 Homo sapiens clone HQ0270 2. 2 425390 A1092634 Hs. 156114 protein tyrosine phosphatase, non-recept 22 408380 AF123050 Hs. 44532 diubiquitin 2. 2 422424 Al186431 Hs. 116577 prostate differentiation factor 2. 2 431548 Api834273 Hs. 9711 Homo sapiens CDNA FU 13018 fis, clone NT 2. 2 400298 AA032279 Hs. 61635 six transmembrane epithelial antigen of 2. 2 428771 AB028992 Hs. 193143 KIAA1069 protein 2. 2 411571 AA122393 Hs. 70811 hypothetical protein FLJ20516 2. 2 442573 H93366 Hs. 7567 Homo sapiens cDNA : FLJ21962 fis, clone H 2. 2 412802 U41518 Hs. 74602 aquaporini (channel-forming integral pr 2. 2 412530 AA766268 Hs. 266273 Homo sapiens cDNA FLJ 13346 fis, clone OV 2. 2 414761 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homolog2 2. 2 408432 AW195262 gb : xn67bO5. xi CGAPCML1 Homo sapiens 2. 2 440283 A1732892 Hs. 190489 ESTs 22 429568 A1088691 Hs. 208414 Homo sapiens mRNA ; cDNA DKFZp564D0472 (f 2. 2 424003 BE274717 Hs. 137506 HomosapiensBACConeRP11-120J2from7 2. 2 425300 AW601773 Hs. 270259 ESTs 2. 2 448568 AA149121 Hs. 71947 ESTs 2. 2 419229 A1827237 Hs. 282884 ESTs 2. 2 420982 AW576160 Hs. 100729 KIAA0692 protein 2. 2 403258 2. 2 439653 AW021103 Hs. 6631 hypothetical protein FLJ20373 2. 2 426827 AW067805 Hs. 172665 methylenetetrahydrofolate dehydrogenase 2. 2 444514 A1682905 Hs. 270431 ESTs, Weakly similar to ALU1HUMANALUS 2. 2 426298 AW965058 Hs. 111583 ESTs 2. 2 425322 U63630 Hs. 155637 protein kinase, DNA-activated, catalytic 2. 2 421662 NM_014141 Hs. 106552 cell recognition molecule Caspr2 2. 2 412505 AA974491 Hs. 21734 ESTs 2. 2 438788 AA825716 gb : od29e10. s1 NCI CGAP GCB1 Homosapiens 2. 2 429058 AF138863 Hs. 194827 hypothetical protein FLB6421 2. 2 423104 AJ005273 Hs. 123647 antigenic determinant of recA protein (m 2. 2 410406 Al969703 Hs. 301842 ESTs 2. 2 443180 R15875 Hs. 70945 ESTs 2. 2 419235 AW470411 Hs. 288433 neurotrimin 2. 2 421379 Y15221 Hs. 103982 small inducible cytokine subfamily B (Cy 2. 2 422809 AK001379 Hs. 121028 hypothetical protein FLJ10549 2. 2 415058 AW902848 Hs. 273829 ESTs 2. 2 418049 AA211467 Hs. 190488 hypothetical protein FU10120 2. 2 436209 AW850417 Hs. 254020 ESTs, Moderately similar to unnamed prot 2. 2 408042 AL049233 Hs. 42244 Homo sapiens mRNA ; cDNA DKFZp564A023 (fr 2. 2 425692 D90041 Hs. 155956 N-acetyltransferase 1 (arylamine N-acety 2. 2 409665 Nom 006731 Hs. 55777 Fukuyama type congenital muscular dystro 2. 2 428157 A1738719 Hs. 298668 ESTs 2. 2 410480 R97457 Hs. 63984 cadherin 13, H-cadhenn (heart) 2. 2 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2 doma 2. 2 414747 U30872 Hs. 77204 centromere protein F (350/400kD, mitosin 2. 2 425843 BE313280 Hs. 159627 death associated protein 3 2. 2 445299 Api910382 Hs. 118727 Homo sapiens cDNA FLJ 13692 fis, clone PL 2. 1 436251 BE515065 Hs. 5092 nucleolar protein (KKE/D repeat) 2. 1 430066 Api929659 Hs. 237825 sign recognition particle 72kD 2. 1 422516 BE258862 Hs. 117950 mulúfuncúonalpolypepúdesimilartoS 2. 1 407870 AB032990 Hs. 40719 hypothetical protein KIM1164 2. 1 416109 AM20311 Hs. 126550 suppressorofK transportdefect 1 2. 1 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 2. 1 448089 A1467945 Hs. 173696 ESTs 2. 1 441790 AW294909 Hs. 132208 ESTs 2. 1 400022 AFFX control : STAT1 2. 1 428728 NM_016625 Hs. 191381 hypothetical protein 2. 1

414366 BE549143 gb : 601076456F1 NIH_MGC_12 Homo sapiens c 2. 1 409929 R38772 Hs. 172619 KIAA1106 protein 2. 1 405264 2. 1 445625 BE246743 Hs. 288529 Homo sapiens cDNA : FLJ22635 fis, clone H 2. 1 408949 AF189011 Hs. 49163 putaúvenbonucleaelll 2. 1 424513 BE385864 Hs. 149894 mitochondriattranstationa ! initiation f 2. 1 433683 A1817723 Hs. 22678 hypotheticalprotein FU21832 2. 1 442952 A1743261 Hs. 131860 ESTs 2. 1 441020 W79283 Hs. 35962 ESTs 2. 1 446770 AV660309 Hs. 154986 ESTs, Weakly similar to AF137386 1 plam 2. 1 432378 A1493046 Hs. 146133 ESTs 2. 1 447769 AW873704 Hs. 48764 ESTs 2. 1 412654 A1093480 Hs. 29263 Homo sapiens cDNA FLJ 11896 fis, clone HE 2. 1 445669 A1570830 Hs. 174870 ESTs 2. 1 417979 AU077284 Hs. 83081 GTP cyclohydrolase I feedback regulatory 2. 1 433849 BE465884 Hs. 280728 ESTs 2. 1 437928 NM005476 Hs. 5920 UDP-N-acetA (ucosamine-2-epimerase/N-ac 2. 1 457341 BE181716 gb : QV1-HT0639-150500-19803HT0639Homo 2. 1 452833 BE559681 Hs. 30736 Kit0124 protein 2. 1 403055 2. 1 414581 AA256213 Hs. 72010 ESTs 2. 1 432840 AK001403 Hs. 279521 hypothetical protein FU20530 2. 1 418994 AA296520 Hs. 89546 selectin E (endothelial adhesion molecul 2. 1 440908 A1915225 Hs. 126735 ESTs 2. 1 417621 AV654694 Hs. 82316 interferon-induced, hepatitis C-associat 2. 1 436895 AF037335 Hs. 5338 carbonic anhydrase XII 2. 1 455716 BE070263 gb : QV4-BT0407-280100-090. e07 BT0407 Homo 2. 1 408420 NM 006915 Hs. 299481 Homo sapiens mRNA ; cDNA DKFZpS86B0118 (f 2. 1 435849 BE305242 Hs. 112442 ESTs, Weakly similar to CLDEHUMAN CLAUD 2. 1 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 2. 1 433644 AW342028 Hs. 256112 ESTs 2. 1 400020 AFFX control : STAT1 2. 1 434064 AL049045 Hs. 180758 hypothetical protein PR00082 2. 1 410660 A1061118 Hs. 65328 Fanconianemia, complementationgroupF 2. 1 404076 2. 1 441362 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re 2. 1 422515 AW500470 Hs. 1 17950 mulfifuncbonal polypepfide similar to S 2. 1 444863 AW384082 Hs. 301323 ESTs 2. 1 445867 AF272663 Hs. 13405 gephyrin 2. 1 441021 AW578716 Hs. 7644 H1 histone family, member 2 2. 1 446595 T57448 Hs. 15467 hypothetical protein FLJ20725 2. 1 417515 L24203 Hs. 82237 ataxia-telangiectasia group D-associated 2. 1 412429 AV650262 Hs. 75765 GR02 oncogene 2. 1 449207 AL044222 Hs. 23255 nudeoponn 155kD 2. 1 412095 A1624707 Hs. 5921 Homo sapiens cDNA : FLJ21592 fis, clone C 2. 1 400861 2. 1 448826 A1580252 Hs. 293246 ESTs, Weakly similar to putative p150 [H 2. 1 440591 AA431599 Hs. 132799 Homo sapiens cDNA : FLJ23451 fis, clone H 2. 1 426181 AA371422 Hs. 69844 ESTs, WeaklysimilartodJ19lN21. 1 [H. sa 2. 1 452880 AA029332 Hs. 87549 ESTs 2. 1 421878 AA299652 Hs. 111496 HomosapienscDNAFW11643hs, cloneHE 2. 1 442104 L20971 Hs. 188 phosphodiesterase 4B, cAMP-specific (dun 2. 1 427224 AL135554 Hs. 101937 sine oculis homeobox (Drosophila) homolo 2. 1 446921 AB012113 Hs. 16530 small inducible cytokine subfamily A (Cy 2. 1 432487 AA550988 Hs. 221472 ESTs 2. 1 429534 AW976987 Hs. 163327 ESTs 2. 1 446051 BE048061 Hs. 153315 ESTs 2. 1 447760 Al431328 Hs. 291179 ESTs, Weakly similar to topoisomerase 1 2. 1 422675 BE018517 Hs. 119140 eukaryotic translation initiation factor 2. 1 415173 AW501735 Hs. 253015 ESTs 2. 1 425170 AU077315 Hs. 154970 transcription factor CP2 2. 1 453751 R36762 Hs. 101282 Homo sapiens mRNA ; cDNA DKFZp434B102 (fr 2. 1 426283 NM_003937 Hs. 169139 kynureninase (L-kynurenine hydrolase) 2. 1 417874 BE616160 Hs. 82829 protein tyrosine phosphatase, non-recept 2. 1 449555 AW450288 Hs. 195390 ESTs 2. 1 439699 AF086534 Hs. 187561 ESTs, ModeratelysimilartoALU1_HUMANA 2. 1 427413 BE547647 Hs. 177781 superoxidedismutae2, mitochondria'2. 1 424673 AA345051 Hs. 294092 ESTs 2. 1 407802 D84145 Hs. 39913 novel RGD-containing protein 2. 0 452834 A1638627 Hs. 105685 ESTs 2. 0 438895 AW007021 Hs. 82894 ESTs 2. 0 446035 NM006558 Hs. 13565 Sam68-like phosphotyrosine protein, T-ST 2. 0 406981 S71129 Hs. 296844 Acetylcholinesterase (14-E5 doman) [huma 2. 0 427001 NM006482 Hs. 173135 dua'-speciEcibbrosine-(Y)-phosphoryl 2. 0 439223 AW238299 Hs. 23945 ESTs 2. 0 432343 NM002960 Hs. 2961 S100 calcium-binding protein A3 2. 0 414890 BE281095 Hs. 77573 uridine phosphorylae 2. 0 423019 A1640185 Hs. 225816 ESTs 2. 0 435905 AW997484 Hs. 5003 KIAA0456 protein 2. 0 422278 AF072873 Hs. 114218 fizzled (Drosophila) homolog 6 2. 0 439608 AW864696 Hs. 26198 Homo sapiens cDNA : FU23363 fis, clone H 2. 0 432114 AL036021 Hs. 225597 ESTs 2. 0 405545 2. 0

418201 AA214345 Hs. 98445 HomosapienscDNA : FLJ21652 fis, clone C 2. 0 442528 AF150317 Hs. 134217 ESTs 2. 0 446237 AW270515 Hs. 149596 ESTs 2. 0 428074 BE387770 Hs. 182378 colony stimulating factor 2 receptor, al 2. 0 423430 AF112481 Hs. 128501 RAD54, S. cerevisiae, homolog ot, 0 435767 H73505 Hs. 117874 ESTs 2. 0 432945 AL043683 Hs. 271357 ESTs, Weakly similar to unnamed protein 2. 0 428792 BE535955 Hs. 193602 chromosome condensation protein G 2. 0 404170 2. 0 410286 A1739159 Hs. 61898 DKFZP586N2124 protein 2. 0 434565 T52172 gb : yb22dOtslstratæenefetalspleen (9 2. 0 422610 AF153820 Hs. 1547 potassium inwardly-rectifying channel, s 2. 0 417933 X02308 Hs. 82962 thymidylate synthetase 2. 0 441384 AA447849 Hs. 288660 protease, serine, 23 2. 0 437403 A1208149 Hs. 121196 ESTs 2. 0 412673 AL042957 Hs. 31845 ESTs 2. 0 414020 NM002984 Hs. 75703 small inducible cytokine A4 (homologous 2. 0 438426 AA835936 Hs. 269763 ESTs 2. 0 413943 AW294416 Hs. 144687 ESTs 2. 0 449001 A1619957 Hs. 189854 ESTs 2. 0 427674 NM 003528 Hs. 2178 H2B histone family, member Q 2. 0 435425 H16263 Hs. 31416 ESTs 2. 0 433364 A1075407 Hs. 296083 ESTs 20 429782 NM 005754 Hs. 220689 Ras-GTPae æffvabng protein SH3-domain 2. 0 417366 BE185289 Hs. 1076 smaitproiine-rich protein IB (comifin) 2. 0 426746 J03626 Hs. 2057 undinemonophosphatesynthetae (aotat 2. 0 411943 BE502436 Hs. 7962 ESTs, Weakly similar to putative [C. eleg 2. 0 414266 BE267834 gb : 601124428F1 NlH_MGC_8HomosapienscD 2. 0 432677 NM 004482 Hs. 278611 UDP-N-acetyl-alpha-D-galactosamine : polyp 2. 0 450534 Api570189 Hs. 25132 KIAA0470geneproduct 2. 0 446715 Al337735 Hs. 173919 ESTs 2. 0 TABLE 42B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 408432 1058667 1 AW195262R27868AW811262 411479 1247077 1 AW848047 AW848202 AW848631 AW848142 AW848702 AW848121 AW848632 AW848140 AW848571 AW848009 AW848067 AW848069 AW848905 AW848214 411560 1249443_1 AW851186AW996967BE143456 414266 1430984 1 BE267834 BE514180 BE514096 414366 1438636 1 BE549143 BE390613 BE277344 414727 1481204_1 BE466904W28721 414800 14918631 BE538690T40217 415666 1543492 1 H72693 R08673 H72694 F20990 R08580 422063 210852 1 BE156476 BE156473 BE156474 BE156475 AA302839 422285 214669 1 A1803103 A1885143 AW470793 AW450703 A1090784 AW271587 AW236950 AW242783 422689 219896 1 AW856665 AA315006 AW954733 423871 232749 1 AA331906 AA332484 429540 305828 1 M85776 AA454535 AA456208 H90189 431453 333457_1 AW753917 BE152926 M505333 BE155673 434414 38585 1 AI798376 S46400 AW811617 AW811616 W00557 BE142245 AW858232 AW861851 AW858362 AA232351 AA218567 AA055556 AW858231 AW857541 AW814172 H66214 AW814398 AF 134164 AA243093 AA173345 AA199942 AA223384 AA227092 AA227080 T12379 AA092174 T61139 AA149776 AA699829 AW879188 AW813567 AW813538 A1267168 AA157718 AA157719 AA100472 AA100774 AA130756 AA157705 AA157730 AA157715 AA053524 AW849581 AW854566 C05254 AW882836 T92637 AW812621 AA206583 AA209204 BE156909 AA226824 AI829309 AW991957 N66951 AA527374 H66215AA045564 A1694265 H60808 AA149726 AW195620 BE081333 BE073424AW817662 AW817705 AW817703 AW817659 BE081531 H59570 434565 38898 1 T52172 AF147324 T52248 436411 419334 1 AW674352M715374Z25205 437834 443674 1 M769294 AW749299 AW749302 AW749295 AW749304 AW749293 AW749298 AW749294 AW749288 AW749291 AW749297 AW749292 AW749296 AW749289 AW749287 BE535498 438788 465159J AA825716AW978859AA828841 454456 1207088_1 AW850984 AW752836 M86124 454678 1228915 1 AW813089W28102 454798 1235104 1 AW821295 AW821272 AW821282 454946 1245753 1 AW846376 AW846375 AW846434 AW846287 AW846365 AW846554 AW846384 AW846290 AW846356 AW846474 455716 1352695_1 BE070263 BE070195 BE070265 BE070202 BE070233 BE070399 BE070203 457341 322221 1 BE181716 AW948314 AW801848 AW948320 AW983981 AA484444 TABLE 42C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers."Dunham, et al.'efers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntjmsition 400861 9757506 Plus 163855-164016 401644 8576138 Plus 82655-83959 401747 9789672 Minus 118596-118816, 119119-119244, 119609-119761, 120422-120990, 130161-130381, 130468-130593, 131097-131258. 131866-31932. 132451- 132575, 133580-134011

402053 8083229 Plus 62703-63179 402819 6729581 Plus 29217-29422 403055 8748904 Minus 109532-110225 403137 9211494 Minus 92349-92572, 92958-93084. 93579-93712, 93949-94072, 94591-94748, 95214-95337 403204 7622392 Plus 16214-16439 403258 7770439 Minus 156251-156619 403776 7770611 Minus 1414-1513, 1624-1756 404076 9931752 Minus 3848-3967 404170 9930793 Plus 168836-169248 405264 7329374 Plus 28556-28684 405454 7656675 Plus 133807-134053 405545 1054740 Plus 118677-118807. 119091-119296, 121626-121823 405695 4309958 Plus 51860-52162 406434 9256651 Minus 17803-17931 TABLE 43A : ABOUT 339 GENES UP-REGULATED IN STOMACH CANCER Table 43A lists about 339 genes up-regulated in stomach cancer compared to normal stomach that are likely to be extracellular or cell-surface proteins. These were selected as for Table 42A and the predicted protein contained a structural domain that is indicative of surface or extracellular localization (e. g. ig, fn3, egf, 7tm domains). Predicted protein domains are noted. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tibe : Unigene gene title PSDomain : Protein Structural Domain RI : Ratio of tumor to normal tissue Pkey ExAccn UnigenelD Unigene Title PSDomain R1 428368 BE440042 Hs. 83326 matrix metallop hemopexin, Peptidase_M10"SS 60. 4 428664 AK001666 Hs. 189095 similartoSALL zf-C2H2, TM, SS 26. 8 422330 D30783 Hs. 115263 epiregulin EGF, TM, SS 22. 0 439979 AW600291 Hs. 6823 hypothetical pr TM 19. 0 451099 R52795 Hs. 25954 interieukin 13 hn3, TM, SS 17. 1 403776 IL8, TM, SS 14. 9 424905 NM002497 Hs. 153704 NIMA (never in pkinase, TM, 14. 8 453922 AF053306 Hs. 36708 budding uninhib TM 13. 8 436032 AA150797 Hs. 109276 latexin protein TM 13. 1 427585 D31152 Hs. 179729 collagen, type Clq, Collagen, TM, SS 12. 5 416661 AA634543 Hs. 79440 IGF-11 mRNA-bin KH-domain, TM, 12. 2 414972 BE263782 Hs. 77695 KIAA0008 gene p TM 10. 6 446619 AU076643 Hs. 313 secreted phosph Osteopontin, TM, SS 10. 5 415138 C18356 Hs. 78045 tissue factor p Kunitz BPTI, G-gamma, TM, SS 9. 6 423020 AA383092 Hs. 1608 replication pro TM 8. 6 408908 BE296227 Hs. 48915 serine/threonin pkinase, TM, SS 8. 5 419948 A8041035 Hs. 93847 NADPH oxidase 4 Ferric reduct, TM, SS 8. 3 411750 BE562298 Hs. 71827 KlM0112protei SS 8. 3 420900 AL045633 Hs. 44269 ESTs Aid_Xan_dh_C, FAD_binding_5, TM, 8. 0 450480 X82125 Hs. 25040 zinc finger pro zf-C2H2, TM, SS 7. 6 417655 AA780791 Hs. 14014 ESTs, Weakly si TM 7. 6 430403 AF039390 Hs. 241382 tumor necrosis TM, SS 7. 5 428330 L22524 Hs. 2256 matrix metallop Peptidase M10"SS 7. 3 452291 AF015592 Hs. 28853 CDC7 (cell divi pkinase, TM, 7. 0 418205 L21715 Hs. 83760 troponin 1, ske Troponin"SS 7. 0 409757 NM001898 Hs. 123114 cystatin SN cystatin"SS 6. 9 444783 AK001468 Hs. 62180 anillin (Drosop PH, TM, 6. 5 416209 AA236776 Hs. 79078 MAD2 (mitotic a HORMA"SS 6. 5 431958 X63629 Hs. 2877 cadherin 3, typ cadherin, Cadherin_C_term, TM, SS 5. 8 424345 AK001380 Hs. 145479 Homo sapiens cD TM, SS 5. 6 428227 AA321649 Hs. 2248 small inducible IL8 TM, SS 5. 4 424960 BE245380 Hs. 153952 5'nucleotidase 5 nucleotidase, TM, SS 4. 9 400268 Myosin_tail"SS 4. 8 411274 NM 002776 Hs. 69423 kallikrein 10 trypsin, TM, 4. 7 415752 BE314524 Hs. 78776 putative transm TM 4. 6 431806 AF186114 Hs. 270737 tumor necrosis TM, SS 4. 6 400205 SS 4. 6 422938 NM001809 Hs. 1594 centromere prot histone, TM, 4. 5 406687 M31126 Hs. 272620 pregnancy speci hemopexin, TM, 4. 4 423871 AA331906 gb : EST35805 Emb TM 4. 4 431211 M86849 Hs. 5566 gapjunctionpr connexin, TM, 4. 4 446638 AL133063 Hs. 15783 Homo sapiens mR TM 4. 3 406741 AA058357 Hs. 74466 carcinoembryoni ig, TM, SS 4. 3 411560 AW851186 gb : IL3-CT0220-1 TM 4. 1 433159 AB035898 Hs. 150587 kinesin-like pr kinesin, Myosin_tail, TM, SS 4. 1 422285 Ai803103 gb : tc14e06. xl S TM, SS 4. 1 451807 W52854 Hs. 27099 DKFZP564J0863 p TM 4. 1 411558 AA102670 Hs. 70725 gamma-aminobuty neur chan, TM, SS 4. 0 415701 NM 003878 Hs. 78619 gamma-glutamyl TM, SS 4. 0 409420 Z15008 Hs. 54451 laminin, gamma laminin EGF, laminin_B"SS 3. 9 452909 NM 015368 Hs. 30985 pannexin 1 TM 3. 9 407788 BE514982 Hs. 38991 S100calcium-bi efhand, S_100, TM, SS 3. 8 421155 H87879 Hs. 102267 hysyioxidase Lysyl oxidae"SS 3. 8 420552 AK000492 Hs. 98806 hypothetical pr SS 3. 8 420727 H75701 Hs. 99886 complementcomp sushi"3. 7

422665 AJ011812 Hs. 119018 transcription f R3H, Gpatch, GTP_CDC, TM, SS 3. 7 447425 A1963747 Hs. 18573 acylphosphatase Acylphosphatase, TM, 3. 7 406076 AL390179 Hs. 137011 Homo sapiens mR TM 3. 6 406434 heme_1, TM, 3. 6 417956 AA210704 Hs. 190465 ESTs sushi"SS 3. 6 410102 AW248508 Hs. 279727 Homo sapiens cD TM, SS 3. 6 426471 M22440 Hs. 170009 transforming gr EGF, TM, SS 3. 5 425782 U66468 Hs. 159525 cell growth reg SS 3. 5 426957 AA393676 Hs. 97459 ESTs, Weakly si SS 3. 5 448105 AW591433 Hs. 170675 ESTs, Weakly si trypsin, TM, 3. 5 414998 NM002543 Hs. 77729 oxidisedlowde TM 3. 5 442942 AW167087 Hs. 131562 ESTs pkinase, TM, SS 3. 4 416391 A1878927 Hs. 79284 mesoderm specif abhydrolase. TM, SS 3. 4 420230 AL034344 Hs. 298020 Homo sapiens cD Fork_head, TM, 3. 4 408243 Y00787 Hs. 624 interleukin 8 IL8, TM, SS 3. 4 412978 Api431708 Hs. 820 homeo box C6 homeobox, TM, 3. 4 412851 A1826502 Hs. 106149 ESTs TM, SS 3. 4 414812 X72755 Hs. 77367 monokine induce IL8., SS 3. 4 453884 AA355925 Hs. 36232 KIAA0186 gene p TM 3. 4 425921 NM 0W231 Hs. 162211 solute carrier SNF, TM, 3. 4 421787 AA227068 Hs. 108301 nuclear recepto TM 3. 3 447342 A1199268 Hs. 19322 ESTs TM, SS 3. 3 452826 BE245286 Hs. 301636 ESTs, Moderate AAA, TM, 3. 3 414821 M63835 Hs. 77424 Fc fragment of ig, TM, SS 3. 3 448756 A1739241 Hs. 171480 ESTs TM 3. 3 421948 L42583 Hs. 111758 keraGn 6A filamentTM, 3. 3 438538 AA832203 Hs. 291955 ESTs TM 3. 3 436391 AJ227892 Hs. 146274 ESTs SS 3. 3 418007 M13509 Hs. 83169 matrix metallop hemopexin, Peptidase M10"SS 3. 2 411678 A1907114 Hs. 71465 squalene epoxid Monooxygenase, TM, 3. 2 422956 BE545072 Hs. 122579 hypothetical pr TM 3. 2 450400 A1694722 Hs. 279744 ESTs TM 3. 2 440659 AF134160 Hs. 7327 claudin 1 PMPZ7_Caudin, TM, SS 3. 2 418203 X54942 Hs. 83758 CDC28 protein k CKS, TM, 3. 1 416111 AA033813 Hs. 79018 chromatinassem TM. SS 3. 1 445808 AV655234 Hs. 298083 ESTs sushi, TM, SS 3. 1 421340 F07783 Hs. 1369 decayæcelerat sushi"SS al 422689 AW856665 gb : RC3-CT0297-2 SNF2_N, TM, 3. 1 439451 AF086270 Hs. 278554 heterochromabn chromo, Chromo shadow"SS 3. 1 454456 AW850984 gb : IL3-CT0220-1 fn3, TM, SS 3. 0 429125 AA446854 Hs. 271004 ESTs TM 3. 0 409361 NM_005982 Hs. 54416 sine oculis hom homeobox"SS 3. 0 439453 BE264974 Hs. 6566 thyroid hormone AAA. TM, 3. 0 414696 AF002020 Hs. 76918 Niemann-Pickdi Patched, TM, SS 3. 0 422746 Nom 004484 Hs. 119651 glypican 3 Glypican, TM, SS 3. 0 453775 NM002916 Hs. 35120 repiicationfac AAA. TM. SS 3. 0 428862 NM 000346 Hs. 2316 SRY (sex-determ HMG_box, TM, 2. 9 401747 filament. TM, 2. 9 429682 NM 006306 Hs. 211602 SMC1 (structura SMC_C, SMC_N, TM, 2. 9 413385 M34455 Hs. 840 indoteamine-pyr IDO, TM, 2. 9 442961 BE614474 Hs. 289074 Homo sapiens cD TM 2. 9 421650 AA781795 Hs. 122587 ESTs TM 2. 9 434398 AA121098 Hs. 3838 serum-inducible pkinase, POLO_box, TM, 2. 9 435706 W31254 Hs. 7045 GL004 protein PDEase. TM, 2. 9 416065 BE267931 Hs. 78996 proliferating c TM 2. 9 423493 Api815965 Hs. 129683 ubiquitin-conju UQ con"SS 2. 8 430242 U66669 Hs. 236642 3-hydroxyisobut TM 2. 8 411770 NM 014278 Hs. 71992 heat shock prot HSP70, TM, 2. 8 400440 X83957 Hs. 83870 nebulin TM 2. 8 444743 AA045648 Hs. 11817 nudix (nucleosi mutT, TM, 2. 8 417771 AA804698 Hs. 82547 retinoic acid r TM 2. 8 430287 AW182459 Hs. 125759 ESTs, Weakly si TM, SS 2. 8 408482 NM000676 Hs. 45743 adenosine A2b r 7tm_1, TM, SS 2. 8 425188 AK002052 Hs. 155071 hypothetical pr TM 2. 8 456999 AA319798 Hs. 172247 eukaryotictran SS 2. 8 408875 NM 015434 Hs. 48604 DKFZP434B168 pr TM 2. 8 409012 AL117435 Hs. 49725 DKFZP4341216 pr RhoGEF, TM, 2. 7 410762 AF226053 Hs. 66170 HSKM-Bprotein zf-MYND"SS 27 426925 NM001196 Hs. 172894 BH3 interacting TM 2. 7 410116 AW630671 Hs. 58636 squamous cell c TM, SS 2. 7 428398 A1249368 Hs. 98558 ESTs SS 2. 7 412140 AA219691 Hs. 73625 RAB6 interactin kinesin, TM, SS 2. 7 456655 A1376736 Hs. 111779 secretedprotei kazal"SS 2. 7 408670 AF160967 Hs. 46784 potassium large TM, SS 2. 7 422576 BE548555 Hs. 118554 CGI-83 protein lactamase_B"SS 2. 7 431379 AA504264 Hs. 182937 pepUdylprolyl TM 2. 7 433183 AF231338 Hs. 222024 transcnption f HLH, PAS, TM, SS 2. 7 432328 A1572739 Hs. 195471 6-phosphofructo PGAM, 6PF2KTM, 2. 7 407633 NM007069 Hs. 37189 similar to rat TM, SS 2. 6 419216 AU076718 Hs. 164021 smali inducible IL8, TM, SS 2. 6 422363 T55979 Hs. 115474 replication fac TM 2. 6 401644 zf-C2H2, TM, 2. 6 417479 A1057052 Hs. 133554 ESTs CARD, TM, 2. 6

426514 BE616633 Hs. 301122 bonemorphogene TGF-beta, TGFb_propepúde, TM, SS 2. 6 400289 X07820 Hs. 2258 matrix metallop hemopexin"SS 2. 6 418478 U38945 Hs. 1174 cyclin-dependen ank, TM, SS 2. 6 421246 AW582962 Hs. 300961 ESTs, Highly Si PolyAol, TM, 2. 6 428048 AA705745 Hs. 185070 ESTs AMP-binding, TM, 2. 6 452092 BE245374 Hs. 27842 hypothetical pr Acyltransferase, TM, SS 2. 6 440052 A1633744 Hs. 195648 ESTs PAC, TM, SS 2. 6 452401 NM 007115 Hs. 29352 tumor necrosis Xfink, CUB, TM, SS 2. 6 451813 NM016117 Hs. 27182 phospholipase A WD40"SS 2. 6 410889 X91662 Hs. 66744 twist (Drosophi HLH, TM, 2. 6 422063 BE156476 gb : QVO-HT0368-0 SS 2. 6 418250 U29926 Hs. 83918 adenosine monop A_deaminase, TM, 2. 6 437641 AA811452 Hs. 291911 ESTs TM 2. 6 452571 W31518 Hs. 34665 ESTs TM 2. 6 411984 NM_005419 Hs. 72988 signal transduc SH2, STAT,. SS 2. 6 426427 M86699 Hs. 169840 TTK protein kin pkinase, TM, 2. 6 445848 AA774824 Hs. 13377 Homo sapiens cl TM 2. 6 420022 AA256253 Hs. 120817 ESTs SS 2. 6 451418 BE387790 Hs. 26369 hypothetical pr TM 2. 6 428953 AA306610 Hs. 194676 DKFZP434C013 pr arf, TNFR_c6, DEAD, Stathmin, TM, SS 2. 6 424008 R02740 Hs. 137555 putative chemok 7t1, TM, 2. 6 417863 AB000450 Hs. 82771 vaccinia relate pkinase, TM, SS 2. 6 436961 AW375974 Hs. 156704 ESTs TM 2. 5 413670 AB000115 Hs. 75470 hypotheticalpr TM 2. 5 421928 AF013758 Hs. 109643 polyadenylate b SS 2. 5 439963 AW247529 Hs. 6793 platelet-activa PAF-AH, HMG_box, pkinae, TM, 25 426711 AA383471 Hs. 180669 conserved gene TM 2. 5 422631 BE218919 Hs. 118793 hypothetical pr TM 2. 5 417866 AW067903 Hs. 82772 coliagen, type TSPN, Collagen, COLFI"SS 2. 5 416975 NM 004131 Hs. 1051 granzyme B (gra trypsin,, SS 2. 5 415947 U04045 Hs. 78934 mutS (E. coli) MutS_C, MutS_N, TM, 2. 5 454678 AW813089 gb : RC3-ST0186-2 TPR, Ribosomal_S5, TM, SS 2. 5 426572 AB037783 Hs. 170623 hypothetcatpr PH. FYVE. TM. 2. 5 428264 AA424839 Hs. 98484 ESTs, Weakly si TM 2. 5 444478 W07318 Hs. 240 M-phase phospho kinesin"SS 2. 5 442295 A1827248 Hs. 224398 Homo sapiens cD Collagen, COLFI, vwc, TM, SS 2. 5 410094 BE147897 Hs. 58593 general transcr TFIIF beta, TM, 2. 4 413998 AW103807 Hs. 243933 ESTs TPRTM, SS 2. 4 412281 A1810054 Hs. 14119 ESTs Ribosomal S7e, TM, 2. 4 446852 AW451643 Hs. 257479 ESTs, Weakly si TM 2. 4 408915 NM 016651 Hs. 48950 heptaceilular c TM, SS 2. 4 442991 BE281238 Hs. 8886 hypothetical pr TM 2. 4 410193 AJ132592 Hs. 59757 zinc finger pro zf-C2H2, TM, 2. 4 410664 NM 006033 Hs. 65370 lipase, endothe Ribosoma_L22, 1ipase, PLAT, TM, SS 2. 4 423453 AW450737 Hs. 128791 CGI-09protein Granin, CDP-OH P transf, TM, 2. 4 411598 BE336654 Hs. 70937 H3 histone fami histone"SS 2. 4 429663 M68874 Hs. 211587 phospholipae A C2, PLA2_B, TM, 2. 4 428242 H55709 Hs. 2250 leukemia inhibi LIF_OSM"SS 2. 4 419559 Y07828 Hs. 91096 ring finger pro zf-C3HC4, zf-B_box, TM, 2. 4 419839 U24577 Hs. 93304 phospholipae A SS 2. 4 402819 IBR, TM, 2. 4 431457 NM012211 Hs. 256297 integnn, alpha FG-GAP, vwa, TM, SS 2. 4 443683 BE241717 Hs. 9676 uncharacterized DUF157, TM, 2. 4 422158 L10343 Hs. 112341 protease inhibi wap,. SS 2. 4 423217 NM000094 Hs. 1640 collagen, type fn3, Collagen, Kunitz BPTl, vwa"SS 2. 4 408321 AW405882 Hs. 44205 conistatin TM 2. 4 419086 NM 000216 Hs. 89591 Kallmannsyndro fn3, wap"SS 2. 4 427722 AK000123 Hs. 180479 hypothetical pr PH"SS 2. 4 405454 TM 2. 4 422168 AA586894 Hs. 112408 S100caicium-bi efhand, TM, 2. 3 421462 AF016495 Hs. 104624 aquaponn 9 MIP, TM, 2. 3 403416 Api744626 Hs. 301506 ESTs, Highly si SS 2. 3 448988 Y09763 Hs. 22785 gamma-am ! nobuty neurchan. TM. SS 2. 3 423198 M81933 Hs. 1634 celidivisionc Rhodanese"SS 2. 3 419926 AW900992 Hs. 93796 DKFZP586D2223 p SS 2. 3 429992 AL050053 Hs. 227397 Homo sapiens mR fn3, TM, SS 2. 3 446232 A1281848 Hs. 165547 ESTs 7tm3, TM, 2. 3 422493 AW474183 Hs. 233816 ESTs TM 2. 3 407047 X65965 gb : H. sapiens SO sodfe, TM, 2. 3 411096 U80034 Hs. 68583 mitochondrial i Peptidase M3"2. 3 426457 AW894667 Hs. 169965 chimerin (chima DAG_PE-bind, RhoGAP, TM, 2. 3 446545 Api431798 Hs. 164192 ESTs. Weakly si TM 2. 3 422094 AF129535 Hs. 272027 F-box only prot TM 2. 3 421933 R98881 Hs. 109655 sex comb on mid SAM, TM, 2. 3 430001 A1580056 Hs. 98992 ESTs TM 2. 3 420802 U22376 Hs. 1334 v-myb avian mye TM 2. 3 402053 gpdh"SS 2. 3 432743 A1146966 Hs. 101656 ESTs SS 2. 3 433409 Api278802 Hs. 25661 ESTs PWWP. PHD, bromodomain, TM, 2. 3 408330 AW182602 Hs. 249954 ESTs TM, SS 2. 3 407807 AL031427 Hs. 40094 Human DNA seque T4 deiodinase, TM, 2. 3 436972 AA284679 Hs. 25640 claudin 3 PiUP22_Oaudin, TM, SS 2. 3 433730 AK002135 Hs. 3542 hypothetical pr TM, SS 2. 3

414839 X63692 Hs. 77462 DNA (cytosine-5 zf-CXXC, BAH, TM, SS 2. 3 438192 Api859065 Hs. 16808 ESTs, Weakly si TM, SS 2. 3 415339 NM_015156 Hs. 78398 KIM0071 protei ELM2, TM, 2. 3 449539 W80363 Hs. 58446 ESTs pkinase, Furin-like, Recep_L_domain, TM, SS 2. 2 450956 AW193531 Hs. 205647 ESTs, Moderatel pkinase, TM, SS 2. 2 430335 D80007 Hs. 239499 KIAA0185 protei S1, TM, 2. 2 417849 AW291587 Hs. 82733 nidagen2 EGF, ldlJept_b, thyroglobulin 1, TM, SS 2. 2 412326 R07566 Hs. 73817 smallinducible IL8"SS 2. 2 408349 BE546947 Hs. 44276 homeo box C10 homeobox. TM, 2. 2 424704 Api263293 Hs. 152096 cytochrome P450 p450,. SS 2. 2 409632 W74001 Hs. 55279 serine (or cyst serpin, TM, 2. 2 415323 BE269352 Hs. 949 neutrophil cyto SH3, TPR, TM, 2. 2 417531 NM_003157 Hs. 1087 serineRhreonin pkinase. TM, 2. 2 403137 mm, TM, SS 2. 2 428479 Y00272 Hs. 184572 cell division c pkinase, TM, SS 2. 2 430200 BE613337 Hs. 234896 geminin TM, SS 2. 2 425390 A1092634 Hs. 156114 proteintyrosin ig, Opiods neuropep, TM, SS 2. 2 408380 AF123050 Hs. 44532 diubiquitin ubiquiGn, 7tm_3, ANF receptor, sushi, 7tm1, TM, 2. 2 422424 Al186431 Hs. 116577 prostate differ TGF-beta"SS 2. 2 400298 AA032279 Hs. 61635 sixtransmembra TM 2. 2 411571 AA122393 Hs. 70811 hypotheticalpr SS 2. 2 412802 U41518 Hs. 74602 aquaporin 1 (ch MIP, TM, 2. 2 414761 AU077228 Hs. 77256 enhancerofzes SET, TM, 2. 2 408432 AW195262 gb : xn67bO5. x1 N TM, SS 2. 2 429568 A1088691 Hs. 208414 Homo sapiens mR mito carr, TM, 2. 2 425300 AW601773 Hs. 270259 ESTs TM 2. 2 439653 AW021103 Hs. 6631 hypotheticalpr TM, SS 2. 2 426827 AW067805 Hs. 172665 methylenetetrah THF DHG CYH, FTHFS, TM, 2. 2 444514 AI682905 Hs. 270431 ESTs. Weakly si cNMP binding, TM, SS 2. 2 425322 U63630 Hs. 155637 protein kinase, MCM, TM, 2. 2 421662 NM014141 Hs. 106552 cell recogn laminin_G, TM, SS 2. 2 438788 AA825716 gb : od29e10. sl N ank, death, RHD, TM, 2. 2 429058 AF138863 Hs. 194827 hypothetical pr TM 2. 2 423104 AJ005273 Hs. 123647 antigenic deter TM 2. 2 410406 Api969703 Hs. 301842 ESTs FGGY, TM, 2. 2 421379 Y15221 Hs. 103982 small inducible IL8, TM, SS 2. 2 422809 AK001379 Hs. 121028 hypotheticatpr) Q. TM. 2. 2 418049 AA211467 Hs. 190488 hypothetical pr TM 2. 2 436209 AW850417 Hs. 254020 ESTs, Moderatel TM, SS 2. 2 408042 AL049233 Hs. 42244 Homo sapiens mR TM 2. 2 425692 D90041 Hs. 155956 N-aceytransfe Acetyltransf2, TM, 2. 2 409665 NM006731 Hs. 55777 Fukuyama type c SS 2. 2 428157 A1738719 Hs. 298668 ESTs hexokinase, TM, 2. 2 410480 R97457 Hs. 63984 cadherin 13, H-cadherin, TM, SS 2. 2 429732 U20158 Hs. 2488 lymphocyte cyto SH2, TM, 2. 2 414747 U30872 Hs. 77204 centromere prot SS 2. 2 425843 BE313280 Hs. 159627 death associate TM 2. 2 445299 A1910382 Hs. 118727 Homo sapiens cD HLH, TM, 2. 1 436251 BE515065 Hs. 5092 nucleolar prote Nop, TM, SS 2. 1 430066 Api929659 Hs. 237825 signal recognit TPR"SS 2. 1 427528 AU077143 Hs. 179565 minichromosome MCM, TM, SS 2. 1 448089 A1467945 Hs. 173696 ESTs TM, SS 2. 1 428728 NM_016625 Hs. 191381 hypothetical pr TM 2. 1 409929 R38772 Hs. 172619 KIAA1106 protei TM 2. 1 405264 SS 2. 1 445625 BE246743 Hs. 288529 Homo sapiens cD TM 2. 1 408949 AF189011 Hs. 49163 putativeribonu Ribonuclease_3, TM, SS 2. 1 424513 BE385864 Hs. 149894 mitochondrial t GTP_EFTU, IF2, TM, 2. 1 433683 Api817723 Hs. 22678 hypothetical pr SS 2. 1 442952 Api743261 Hs. 131860 ESTs TM 2. 1 432378 A1493046 Hs. 146133 ESTs TM 2. 1 417979 AU077284 Hs. 83081 GTPcyclohydrol TM, SS 2. 1 433849 BE465884 Hs. 280728 ESTs SS 2. 1 437928 NM_005476 Hs. 5920 UDP-N-acetylglu ROK, Epimerase_2. TM, 2. 1 403055 filament, TM, SS 2. 1 432840 AK001403 Hs. 279521 hypothetical pr TM 2. 1 418994 AA296520 Hs. 89546 selecún E (end EGF, lectin_c, sushi, TM, SS 2. 1 440908 Al915225 Hs. 126735 ESTs TM 2. 1 417621 AV654694 Hs. 82316 interferon-indu TM 2. 1 436895 AF037335 Hs. 5338 carbonic anhydr carb_anhydrase, TM, SS 2. 1 408420 NM 006915 Hs. 299481 Homo sapiens mR TM 2. 1 434064 AL049045 Hs. 180758 hypotheticalpr cadherin, TM, SS 2. 1 404076 RmaAD, TM, 2. 1 422515 AW500470 Hs. 117950 multifunctional AIRC, SAICAR_synt, TM, 2. 1 445867 AF272663 Hs. 13405 gephyrin MoCF biosynth, TM, 2. 1 441021 AW578716 Hs. 7644 Hthistonefami) inkerhistone. TM. 2. 1 446595 T57448 Hs. 15467 hypothetical pr TM, SS 2. 1 417515 L24203 Hs. 82237 ataxia-telangie zf-B box"SS 2. 1 412429 AV650262 Hs. 75765 GR02 oncogene IL8, TM, SS 2. 1 449207 AL044222 Hs. 23255 nucleoporin 155 TM, SS 2. 1 412095 Al624707 Hs. 5921 Homo sapiens c0 TM, SS 2. 1 400861 pkinase, TM, 2. 1 440591 AA431599 Hs. 132799 Homo sapiens cD TM 2. 1

442104 L20971 Hs. 188 phosphodiestera PDEae, TM, 2. 1 446921 AB012113 Hs. 16530 smallinducible IL8"SS 446051 BE048061 Hs. 153315 ESTs Reprolysin, Pep_M12B_propep, TM, SS 2. 1 422675 BE018517 Hs. 119140 eukaryotictran eIF-5a. TM, 2. 1 425170 AU077315 Hs. 154970 transcription f TM 2. 1 453751 R36762 Hs. 101282 Homo sapiens mR TM 2. 1 426283 Nom003937 Hs. 169139 kynureninase (L TM 2. 1 417874 BE616160 Hs. 82829 protein tyrosin Y-phosphatase, TM, 2. 1 449555 AW450288 Hs. 195390 ESTs TM 2. 1 439699 AF086534 Hs. 187561 ESTs, Moderate) TM 2. 1 427413 BE547647 Hs. 177781 superoxide dism sodfe, TM, 2. 1 407802 D84145 Hs. 39913 novel RGD-conta hexapep, TM, SS 2. 0 446035 NM_006558 Hs. 13565 Sam68-like phos TM 2. 0 406981 S71129 Hs. 296844 Acetyicholinest COesterase, TM, SS 2. 0 432343 NM_002960 Hs. 2961 S100calcium-bi S-100, efhand, TM, SS 2. 0 414890 BE281095 Hs. 77573 uridinephospho PNPUDP 1. TM. SS 2. 0 423019 A1640185 Hs. 225816 ESTs SS 2. 0 422278 AF072873 Hs. 114218 frizzled (Droso Fz, Frizzled, TM, SS 2. 0 405545 ABC_tran, ABC_membrane, TM, SS 2. 0 446237 AW270515 Hs. 149596 ESTs bZIP, TM, 2. 0 428074 BE387770 Hs. 182378 colony stimulat SS 2. 0 423430 AF112481 Hs. 128501 RAD54, S. cerev SNF2_N, helicae_C, TM, 2. 0 435767 H73505 Hs. 117874 ESTs Peptidae_S8, P, TM, 2. 0 432945 AL043683 Hs. 271357 ESTs. Weakly si PK"SS 2. 0 404170 sodfe, TM, 2. 0 422610 AF153820 Hs. 1547 potassium inwar IRK, TM, 2. 0 417933 X02308 Hs. 82962 thymidylate syn thymidylat_synl"SS 2. 0 441384 AA447849 Hs. 288660 protease, serin TM 2. 0 414020 NM 002984 Hs. 75703 small inducible IL8"SS 2. 0 427674 NM 003528 Hs. 2178 H28 histone fam histone, TM, SS 2. 0 435425 H16263 Hs. 31416 ESTs TM 2. 0 429782 NM 005754 Hs. 220689 Ras-GTPase-acG mm, NTF2,. SS 2. 0 417366 BE185289 Hs. 1076 small proline-r Cornifin, TM, 2. 0 426746 J03626 Hs. 2057 uridine monopho Pribosyltran, OMPdecase, TM, 2. 0 432677 NM004482 Hs. 278611 UDP-N-acetyl-al Glycos transf_2. Ricin 8 Iectin, TM, 2. 0 TABLE 43B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 408432 1058667 AW195262 R27868 AW811262 411560 1249443_1 AW851186AW996967BE143456 422063 210852_1 BE156476 BE156473 BE156474 BE156475 M302839 422285 214669 1 AI803103 AI885143 AW470793 AW450703 A1090784 AW271587 AW236950 AW242783 422689 219896 1 AW856665 AA315006 AW954733 423871 232749J AA331906AA332484 438788 465159 1 AA825716 AW978859 AA828841 454456 1207088 1 AW850984 AW752836 M86124 454678 1228915_1 AW813089W28102 TABLE 43C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al."refers to the publication entitled'The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 400861 9757506 Plus 163855-164016 401644 8576138 Plus 82655-83959 401747 9789672 Minus 118596-118816. 119119-119244. 119609-119761. 120422-120990. 130161-130381. 130468-130593. 131097-131258. 131866- 131932, 132451-132575. 133580-134011 402053 8083229 Plus 62703-63179 402819 6729581 Plus 29217-29422 403055 8748904 Minus 109532-110225 403137 9211494 Minus 92349-92572, 92958-93084, 93579-93712, 9394g94072, 94591-94748, 95214-95337 403776 7770611 Minus 1414-1513, 1624-1756 404076 9931752 Minus 3848-3967 404170 9930793 Plus 16883&169248 405264 7329374 Plus 28556-28684 405454 7656675 Pius 133807-134053 405545 1054740 Plus 118677-118807. 119091-119296, 121626-121823 406434 9256651 Minus 17803-17931 TABLE 44A : ABOUT 314 GENES DOWN-REGULATED IN STOMACH CANCER Table 44A lists about 314 genes significantly down-regulated in stomach cancer compared to normal stomach. These were selected as for Table 42A, except that the numerator and denominator were switched. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number

Unigene Tiúe : Unigene gene title R1 : Ratio of tumor to normal tissue Pkey ExAccn UnigenelD Unigene Titie R1 412859 NM000705 Hs. 813 ATPase, HUK+exchanging, betapolypepU 0. 01 415447 Z97171 Hs. 78454 myocilin, trabecular meshwork inducible 0. 05 427469 AA403084 Hs. 269347 ESTs 0. 05 407486 S69741 gb : hSCG-3=stomach cancer gene-3 (oncogen 0. 06 428602 AL137479 Hs. 186655 Homo sapiens mRNA ; cDNADKFZp434M0223 (f 0. 06 402761 BE387621 Hs. 108809 chaperonin containing TCP1, subunit 7 (e 0. 07 443547 AW271273 Hs. 23767 HomosapienscDNAFW12666hs, cloneNT 0. 07 430130 AL137311 Hs. 234074 HomosapiensmRNA ; cDNADKFZp761G02121 (0. 07 435473 N53550 Hs. 260881 ESTs 0. 07 455826 8E144228 gb : MRO-HT0165-140200-00904HT0165Homo 0. 07 402015 0. 08 430664 AW969834 gb : EST3819t2 MAGE resequences, MAGK Homo 0. 09 444515 AW204908 Hs. 169979 ESTs 0. 09 429201 X03178 Hs. 198246 group-specific component (vitamin D bind 0. 10 434424 Api811202 Hs. 125365 Homo sapiens cDNA : FU23523 fis, clone L 0. 10 450940 A1744943 Hs. 300744 ESTs, Moderately similar to ALU7_HUMAN A 0. 10 400811 AF219139 Hs. 87726 K) AA0154 protein ; ADP-dbosylation facto 0. 10 424596 AB020639 Hs. 151017 estrogen-related receptor gamma 0. 11 403670 0. 11 410234 NM 003837 Hs. 61255 fructose-1, 6-bisphosphatase2 0. 12 407462 AJ252011 gb : Homo sapiens partial mRNA for amilori 0. 13 405110 0. 13 402760 0. 13 408947 AL080093 Hs. 49117 Homo sapiens mRNA ; cDNA DKFZp564N1662 (f 0. 13 413724 AA131466 Hs. 23767 Homo sapiens CONA FU 12666 fis, clone NT 0. 14 431514 AW972363 gb : EST384454 MAGE resequences, MAGL Homo 0. 14 451103 R52804 Hs. 25956 DKFZP564D206 protein 0. 14 452033 AW273741 Hs. 246977 ESTs 0. 16 440058 A1932662 Hs. 164073 ESTs 0. 16 405645 0. 17 429093 NM 000253 Hs. 195799 microsomattrigiycehde transfer protein 0. 17 445627 AW818475 Hs. 7363 ESTs 0. 19 425679 X05997 Hs. 159177 lipase, gastric 0. 19 417296 L36196 Hs. 81884 sulfotransferase family, cytosolic, 2A, 0. 19 443537 D13305 Hs. 203 cholecystokinin B receptor 0. 20 435654 AW139612 Hs. 131041 ESTs 0. 20 406326 0. 20 454120 AB032990 Hs. 40719 hypotheticalprolemKIM1164 0. 20 455541 AW993005 gb : RC2-BN0032-160200-013-d04BN0032Homo 0. 21 453989 M63962 Hs. 36992 ATPase, H/K+exchanging, alphapolypept 0. 23 407261 L03172 gb : Homo sapiens cell-type T-cell immunog 0. 23 451062 AL110125 Hs. 25910 Homo sapiens mRNA ; cDNA DKFZp564C1416 (f 0. 23 429350 A1754634 Hs. 131987 ESTs 0. 23 411021 F00055 Hs. 172004 Utin 0. 24 441212 AW242447 Hs. 146182 ESTs, Weakly similar to lactase phlorizi 0. 24 450572 AI700863 Hs. 202494 Homo sapiens cDNA FU 13245 fis, clone OV 0. 25 444922 A1921750 Hs. 144871 Homo sapiens cDNA FW13752 fis, clone PL 0. 26 421562 AA530994 Hs. 105803 ghrelin precursor 0. 26 457432 NM005136 Hs. 268538 potassium voltage-gated channel, Isk-rel 0. 26 418421 R58620 Hs. 85050 phospholamban 0. 26 424104 AA669515 Hs. 144950 ESTs 0. 26 422582 AA312660 gb : EST183335 Jurkat T cells Vl Homo sapi 0. 26 417332 AW972717 Hs. 288462 HomosapienscDNA : FU21511 fis, clone C 0. 27 432440 X63597 Hs. 2996 sucrase-isomaltase 0. 27 448520 AB002367 Hs. 21355 doublecortin and CaM kinase-like 1 0. 28 401989 0. 28 452528 AA742457 Hs. 291479 ESTs 0. 28 412569 H63789 Hs. 296288 ESTs, Weakly similar to KIAA0638 protein 0. 28 434779 AF153815 Hs. 50151 potassium inwardly-rectifying channel, s 0. 28 406255 0. 29 419293 AA746282 Hs. 255659 ESTs 0. 29 428649 AL045716 Hs. 188228 HomosapienscDNAFW11Q03fis, clonePL 0. 29 410036 R57171 Hs. 57975 calsequestrin 2, cardiac muscle 0. 29 414502 AL133721 Hs. 224680 ESTs 0. 29 432113 AA935065 Hs. 152385 ESTs 0. 29 413808 J00287 Hs. 182183 caldesmon 1 0. 29 451406 AI694320 Hs. 6295 ESTs, WeaklysimilartoT17248hypotheti 0. 29 434745 AW974445 Hs. 185155 ESTs, Weakly similar to HuEMAP [H. sapien 0. 30 420444 A1905985 Hs. 111805 ESTs 0. 30 445200 AA084460 Hs. 12409 somatostatin 0. 30 415314 N88802 Hs. 5422 glycoprotein M6B 0. 30 427019 AA001732 Hs. 173233 hypothetical protein FU10970 0. 30 431152 AW970998 gb : EST383083 MAGE resequences, MAGK Homo 0. 30 432306 Y18207 Hs. 274315 protein phosphatase 1, regulatory (inhib 0. 31 401775 0. 31 440059 AW467335 Hs. 257676 ESTs 0. 31 436089 AA804957 Hs. 119840 ESTs 0. 31 447071 AW236867 Hs. 244376 ESTs 0. 32 435604 AA625279 Hs. 26892 uncharacterized bone marrow protein BM04 0. 32

423968 AF098277 Hs. 136529 solute carrier family 23 (nudeobasetra 0. 32 445487 A1806287 Hs. 201217 ESTs 0. 32 421296 NM002666 Hs. 103253 perilipin 0. 32 427138 N77624 Hs. 173717 phosphatidic acid phosphatase type 2B 0. 33 449916 T60525 Hs. 299221 ESTs 0. 33 446393 AW014174 Hs. 151707 ESTs 0. 33 446632 Api333565 Hs. 159073 diacylglycerol kinase, eta 0. 33 428070 T63918 Hs. 182313 retinol-binding protein 2, cellular 0. 33 421451 AA291377 Hs. 50831 ESTs 0. 33 405817 0. 33 454790 AW820852 gb : RC2-ST0301-120200-011-f12ST0301Homo 0. 33 413679 BE156765 gb : RCt-HT037Q120100. 01209 HT0370 Homo 0. 34 404121 0. 34 433084 M18079 Hs. 282265 fatty acid binding protein 2, intestinal 0. 34 413079 BE064382 gb : RC4-BT0310-110300-015-ci2 BT0310 Homo 0. 34 403059 0. 35 458987 AW750067 Hs. 205386 ESTs 0. 35 429609 AF002246 Hs. 210863 cell adhesion molecule with homology to 0. 35 423371 AU076819 Hs. 1650 solute carrier family 26, member 3 0. 35 424765 AA428211 Hs. 284256 hypothetical protein FU 14033 similar to 0. 35 451818 Api819018 gb : tsS4fO1. xl NCl_CGAP Kid8Homosapiens 0. 35 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 0. 35 405742 0. 35 403429 0. 35 443622 A1911527 Hs. 11805 ESTs 0. 36 404973 0. 36 444567 AV654020 Hs. 184261 ESTs, Weakly similar to putative type 11 0. 36 412228 AW503785 Hs. 73792 complement component (3d/Epstein Barr vi 0. 36 407110 AA018042 Hs. 95078 ESTs 0. 36 411671 BE049094 Hs. 278567 ESTs 0. 36 430800 NM000805 Hs. 2681 gatrin 0. 36 454560 AW807281 gb : MR4-ST0062-240300-003-g01ST0062Homo 0. 36 444536 A1161068 Hs. 14780 ESTs 0. 36 454042 H22570 Hs. 172572 hypothetical protein Fla20093 0. 37 444102 AV647953 Hs. 282379 ESTs 0. 37 424122 AA335593 Hs. 116147 ESTs 0. 37 452093 AA447453 Hs. 27860 Homo sapiens mRNA ; cDNA DKFZp586M0723 (f 0. 37 436277 R88520 Hs. 120917 ESTs 0. 37 456350 BE246762 Hs. 89499 arachidonate 5-lipoxygenase 0. 37 451027 AW519204 Hs. 40808 ESTs 0. 37 426784 U03749 Hs. 172216 chromogranin A (parathyroid secretory pr 0. 38 410023 AB017169 Hs. 57929 slit (Drosophila) homolog 3 0. 38 436802 N34486 Hs. 170504 ESTs 0. 38 448142 A1521768 Hs. 164586 ESTs 0. 38 442378 R54033 Hs. 21245 ESTs 0. 38 446406 A1553681 Hs. 25248 ESTs 0. 38 455753 BE075124 gb : PM1-BT058S110200-003-hO2BT0585Homo 0. 38 424903 T26477 Hs. 22883 ESTs, Weakly similar to ALU8_HUMAN ALU S 0. 38 406714 A1219304 Hs. 283108 hemoglobin, gamma G 0. 39 434340 A1193043 Hs. 128685 ESTs 0. 39 406036 0. 39 431078 U82827 Hs. 249195 homeo box A13 0. 39 - 457663 AW371946 Hs. 116119 ESTs 0. 39 451880 A1821032 Hs. 209387 ESTs 0. 39 419219 AW583139 Hs. 89717 carboxypeptidase A2 (pancreatic) 0. 39 446414 W93246 Hs. 59187 ESTs 0. 39 442317 A1915599 Hs. 129225 ESTs 0. 39 447261 NM006691 Hs. 17917 lymphatic vessel endothelial hyaluronan 0. 39 439569 AW602166 Hs. 222399 CEGP1 protein 0. 39 433485 A1493076 Hs. 78183 aldo-keto reductase family 1, member C1 0. 40 432753 NM 014075 Hs. 278915 PR00593 protein 0. 40 420200 Al271429 Hs. 88142 ESTs 0. 40 421863 A1952677 Hs. 108972 Homo sapiens mRNA ; cDNA DKFZp434P228 (fr 0. 40 453950 AA156998 Hs. 211568 eukaryotictransiationinitiationfactor 0. 40 407408 AF054830 gb : Homo sapiens interleukin-1 type I rec 0. 40 410732 AW984328 gb : PM3-HN0010-050400-001-h12 HN0010 Homo 0. 40 458272 A1797360 Hs. 264899 ESTs. Weakly similar to ALU3 HUMAN ALU S 0. 40 401514 AF147186 gb : AF147186 Homo sapiens library (Schere 0. 40 436363 AA843926 Hs. 124434 ESTs 0. 40 434445 A1349306 Hs. 11782 ESTs 0. 40 413272 AA127923 Hs. 293256 ESTs 0. 40 409681 N51508 Hs. 143718 ESTs 0. 40 454554 AW847505 gb : RCO-CT0210-230999-021-clOCT0210Homo 0. 40 45089'Al743118 Hs. 238914 ESTs. Weaklysimilartoneuregulin4sho 0. 40 452078 AA022620 Hs. 52170 ESTs 0. 41 419278 AU076799 Hs. 1247 apolipoprotein A-IV 0. 41 433637 AW024214 Hs. 135405 ESTs 0. 41 449923 BE258051 gb : 601111034F1 NIH MGC 16Homosapiensc 0. 41 416982 J05401 Hs. 80691 creaúne kinae, mitochondnãl 2 (sarcom 0. 41 453139 AA330620 Hs. 240559 ESTs 0. 41 408614 AL137698 Hs. 46531 HomosapiensmRNA ; cDNADKFZp434C1915 (f 0. 41 437931 A1249468 Hs. 145274 ESTs 0. 41 402759 0. 41

450888 AW021446 Hs. 80714 ESTs 0. 41 417318 AW953937 Hs. 12891 ESTs 0. 41 407244 M10014 Hs. 75431 fibrinogen, gamma polypeptide 0. 41 424884 AW299437 Hs. 225717 ESTs 0. 41 439024 R96696 Hs. 35598 ESTs 0. 42 423732 AF058056 Hs. 132183 solutecamerfamily16 (monocarboxylic 0. 42 409300 AA126190 gb : zm78fO3. r1 Stratæene neurpithelium 0. 42 444237 AA336878 Hs. 9842 Human DNA sequence from clone RP4-788L20 0. 42 425860 L29339 Hs. 1964 solutecamerfamilyS (sodium/glucose 0. 42 447021 A1356564 Hs. 161406 ESTs 0. 42 422270 AF114494 Hs. 114062 protein tyrosine phosphatase-like (proli 0. 42 407850 AW086230 Hs. 244912 ESTs 0. 42 449884 A1673110 Hs. 222195 ESTs 0. 42 436327 AA813075 Hs. 120181 ESTs 0. 42 415972 H11436 Hs. 260201 ESTs 0. 42 400917 0. 43 435309 AW089050 Hs. 187993 ESTs 0. 43 424410 W79027 Hs. 271762 ESTs 0. 43 445577 N40696 Hs. 146077 ESTs 0. 43 411069 AL133092 Hs. 68055 hypothetical protein DKFZp43410428 0. 43 440286 U29589 Hs. 7138 cholinergic receptor, muscarinic 3 0. 43 451123 A1927224 Hs. 213480 ESTs 0. 43 457151 AW206116 Hs. 253538 ESTs 0. 43 459185 Api908222 gb : RC-BT16S3Q0399-020BT165Homosapien 0. 43 411607 AW853498 gb : RC1-CT0252-170200-025-h02CT0252Homo 0. 43 424815 AA347287 Hs. 104573 ESTs 0. 43 429704 AA584440 Hs. 185812 ESTs 0. 43 411067 A1681006 Hs. 301543 ESTs 0. 43 430172 AA468591 Hs. 161889 ESTs 0. 43 435124 AA725362 Hs. 120456 ESTs 0. 43 445966 L17330 Hs. 280 pre-T/NK cell associated protein 0. 43 443741 AW451759 Hs. 145420 ESTs 0. 43 416275 H42823 Hs. 155742 glyoxylate reductase/hydroxypyruvate red 0. 44 451138 W92287 Hs. 40268 ESTs 0. 44 409038 T97490 Hs. 50002 small inducible cytokine subfamily A (Cy 0. 44 426730 AL040738 gb : DKFZp43481615 r1 434 (synonym : htes3) 0. 44 410066 AL117664 Hs. 58419 DKFZP586L2024 protein 0. 44 427965 D00306 Hs. 183864 elastase 3B 0. 44 418026 BE379727 Hs. 83213 fatty acid binding protein 4, adipocyte 0. 44 408479 BE047329 Hs. 144483 ESTs 0. 44 457994 AW136239 Hs. 132922 ESTs 0. 44 435564 AF210652 Hs. 16614 5 (3)-deoxyribonucleotidase (dNT-2) ; nucl 0. 45 435869 AF255910 Hs. 54650 vascular endothelial junction-associated 0. 45 434399 AA878845 Hs. 125769 ESTs 0. 45 415797 A1291896 Hs. 72800 ESTs 0. 45 430264 AA470519 gb : nc71f10. sl NCI_CGAP_Pr1 Homo sapiens 0. 45 409435 A1810721 Hs. 95424 ESTs 0. 45 433542 AA598869 Hs. 173770 ESTs 0. 45 455400 AW936342 gb : QV4-DT0021-281299-070-h12DT0021Homo 0. 45 412047 AA934589 Hs. 49696 ESTs 0. 45 443948 T56148 Hs. 9997 Homo sapiens mRNA full length insertcDN 0. 45 450307 AW450336 Hs. 201783 ESTs 0. 45 434500 AF143877 Hs. 215047 Homo sapiens clone IMAGE : 113431mRNAseq 0. 45 420460 AA262331 Hs. 135503 ESTs 0. 45 450752 AA012986 Hs. 60466 ESTs 0. 45 418138 AA213626 Hs. 136204 EST 0. 45 441088 AA916546 Hs. 126546 ESTs 0. 46 410990 AW812929 gb : RC3-ST0186-250200-018c05 ST0186 Homo 0. 46 438211 T08401 gb : EST06292 Infant Brain, Bento Scares H 0. 46 434349 NM015678 Hs. 3821 neurobeachin 0. 46 409824 AW501063 gb : UI-HF-BPOp-aiz-c-014Ui. r1 NIH_MGC_5 0. 46 403279 0. 46 434882 AW974752 Hs. 269497 ESTs 0. 46 404629 0. 46 427393 AB029018 Hs. 177635 KIAA1095 protein 0. 46 454651 AW812091 gb : RC4-ST0173-191099-032-b04 ST0173 Homo 0. 46 401992 0. 46 457275 AA463422 Hs. 209431 ESTs 0. 46 403710 0. 46 419728 L36861 Hs. 92858 guanylate cyclase activator 1A (retina) 0. 46 401075 0. 46 421387 AF059566 Hs. 103983 solute carrier family 5 (sodium iodide s 0. 46 453404 AA035446 Hs. 261224 ESTs 0. 46 407208 T10695 Hs. 102948 enigma (LIM domain protein) 0. 46 440681 AW449696 Hs. 166547 ESTs 0. 46 454206 AW810279 gb : MR4-ST0125-151299-029-a09ST0125Homo 0. 47 402466 0. 47 429996 N90822 Hs. 48969 ESTs 0. 47 403680 0. 47 428151 AA422028 gb : zv26gO6. r1 Soares_NhHMPu_S1 Homosapi 0. 47 410495 N95428 gb : zb80dO9. s1 Soares_senescent_fibrobla 0. 47 402851 0. 47 438421 AA806907 Hs. 194451 ESTs 0. 47

454661 BE244138 gb : TCBAP1E1218 PediaNc pre-B cell acut 0. 47 408753 A1337192 Hs. 47438 SH3 domain binding glutamic acid-rich pr 0. 47 409106 AW337854 Hs. 177386 ESTs 0. 47 413199 M62843 Hs. 75236 ELAV (embryonic lethal, abnormal vision, 0. 47 0. 47 442799 A1564739 Hs. 68505 ESTs 0. 47 457955 A1208986 Hs. 143945 ESTs 0. 47 458147 AW752597 gb : L3-CT0214-161299-045-B06CT0214Homo 0. 47 407938 AA905097 Hs. 85050 phospholamban 0. 47 414141 BE255083 gb : 601111390F1 NIH MGC 16Homosapiensc 0. 47 448869 A1792798 Hs. 12496 ESTs 0. 47 400749 0. 47 458745 AW207347 Hs. 211101 ESTs 0. 48 418437 AA771738 Hs. 295351 ESTs 0. 48 452286 A1358570 Hs. 123933 ESTs 0. 48 430369 AA477631 Hs. 119484 ESTs 0. 48 453572 AA382590 Hs. 31848 ESTs, Weakly similar to hypothetical pro 0. 48 455175 AW993247 gb : RC2-BN0033-180200-014-h09 BN0033 Homo 0. 48 445765 AV655102 Hs. 117266 ESTs 0. 48 400322 AF045576 Hs. 247758 olfactory receptor, family 5, subfamily 0. 48 412526 M90366 Hs. 73982 zonapellucidaglycoprotein2 (spemmrec 0. 48 407986 U32659 Hs. 41724 inbrieuhn 17 (cytotoxicT-lymphocyte-a 0. 48 455479 AW948312 gb : RCO-MT0015-280300-021-h04 MT0015 Homo 0. 48 450308 A1692571 Hs. 201681 ESTs 0. 48 411149 N68715 Hs. 269128 ESTs 0. 48 453982 AW014252 Hs. 252837 ESTs 0. 48 410971 AW812258 gb : RCO-ST0174-191099-031-bO2 ST0174 Homo 0. 48 410839 NM006849 Hs. 66581 protein disulfide isomerase 0. 48 421553 AA536080 Hs. 97302 ESTs 0. 48 442376 W95588 Hs. 129982 Homo sapiens cDNA FLJ 12228 fis, clone MA 0. 48 454754 AW819191 gb : CM1-ST0283-071299-061-d08 ST0283 Homo 0. 48 447858 AW080339 Hs. 211911 ESTs 0. 49 422639 AI929377 Hs. 173724 creatine kinase, brain 0. 49 402449 0. 49 420440 NM002407 Hs. 97644 mammaglobin 2 0. 49 435056 AW023337 Hs. 5422 glycoprotein M6B 0. 49 419543 AA244170 Hs. 188719 ESTs 0. 49 407033 U78628 gb : Human leukemia inhibitory factor rece 0. 49 437468 AA457619 gb : aa89dl rlStratæenefetalreúna93 0. 49 412639 AW961284 Hs. 296235 ESTs 0. 49 406109 0. 49 404519 0. 49 410285 AA083609 gb : zm63dO5. rl Stratagene fibroblast (937 0. 49 406014 0. 49 400938 0. 49 414290 A1568801 Hs. 71721 ESTs 0. 49 432433 AW014734 Hs. 157969 ESTs 0. 49 405273 0. 49 454738 BE072139 gb : PM1-BT0533-291299-002-b05 BT0533 Homo 0. 49 414383 BE279406 gb : 601157981F1 NIH MGC 21 Homosapiensc 0. 49 445911 A1985987 Hs. 145645 ESTs, Moderately similar to ALU1 HUMAN A 0. 49 451241 A1767545 Hs. 209572 ESTs 0. 49 428336 AA503115 Hs. 183752 microseminoprotein, beta-0. 49 418310 AA814100 Hs. 86693 ESTs 0. 49 452152 AL046755 Hs. 28219 protein phosphatase 2 (formerly 2A), reg 0. 49 454869 AW836004 gb : PMOLT0019-170200-001-dll LT0019Homo 0. 49 400332 S66407 Hs. 248032 FLT4 0. 49 425280 U31519 Hs. 1872 phosphoenolpyruvate carboxykinase I (sol 0. 49 408221 AA912183 Hs. 47447 ESTs 0. 49 440179 A1990151 Hs. 125904 ESTs 0. 50 425360 BE547704 gb : 601076309F1 NlH_MGC_12Homosapiensc 0. 50 406600 0. 50 418594 A1732083 Hs. 187619 ESTs 0. 50 432128 AA127221 Hs. 117037 ESTs 0. 50 458611 A1268407 Hs. 211458 ESTs 0. 50 426495 NM_001151 Hs. 2043 solutecamerfamily25 (mitochondnå 0. 50 441068 AA913897 Hs. 233559 ESTs 0. 50 428108 AA421452 Hs. 164851 ESTs 0. 50 400803 0. 50 439996 AA916565 Hs. 221675 ESTs 0. 50 TABLE 44B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accession 409300 111676_1 AA126190 AA074486 AA074707 AA070059 AA084886 409824 11554991 AW501063AW503034AW501523 410285 119128 1 M083609M083790M112048 410495 12058261 N95428W24040AW751366H81987 410732 1218556 1 AW984328 AW984322 AW984318 AW984330 R58427 AW984332 AW799807 AW984321 410971 12282161 AW812258AW812252AW812261 AW812263AW812285AW812277AW812264 410990 1228649_1 AW812929 AW812779 AW813088

411607 1251251 1 AW853498 AW853442 AW853590 AW853433 AW853592 413079 1348528 1 BE064382 BE064387 BE064385 BE064381 1 BE 153367 BE 153366 BE153401 BE 153385 BE064372 413679 1382784_1 BE156765 BE156770 BE 156767 BE156769 BE156303 BE 156802 BE156847 BE156853 BE156780 BE156836 BE156792 BE 156334 BE156779 BE156789 BE156833 BE156844 BE156831 BE156849 BE156797 BE156784 BE156801 BE156843 BE156793 BE156852 414141 1420715 1 BE255083 BE257634 414383 1440279 1 BE279406 BE280100 422582 218132_1 M312660AI474863 425360 250631 BE547704 AA355909 426730 271055_1 AL040738 M383683 428151 287658 AA422028W79191 430264 315008 1 AA470519 BE303010 BE302954 BE384120 430664 321423 AW969834AA528493AA483165AW969842 431152 328675 1 AW970998 AW971004 AA574217 AA493538 431514 334213_1 AW972363M506335AI077445 437468 43743 1 AA457619 AL390167 438211 45225 1 T08401 Z83934 T16897 449923 81926_1 BE258051 R45758M004732BE255126 451818 887271 1 A1819018 R05492 W27615 454206 1050848. 1 AW810279 BE146684 BE146693 BE146694 BE146679 AW810472 AW810208AW810356 AW810193AW178838 AW178837 AW178857 AW810515 AW810330 AW810514 AW810441 AW810358 AW178852 AW810359 AW810322 AW810327 AW810211 AW178835 AW810635 AW810288 AW810263 AW810325 AW810443 AW8101 98 AW81032 1 AW810265 AW810567 AW810447 AW810328 AW810513 BE146674 AW810257 AW8101 85 AW81028 1 AW810258 BE062400 AW810323 AW810293 BE146652 AW810516 BE146689 AW810289 AW810566 AW810636 AW178842 BE062434 BE146653 AW810536 AW846649 454554 1223842_1 AW847505 AW811792 BE06 1442 BE061433 AW847506 AW806999 AW806996 BE061436 BE061430 BE142460 BE146499 AW806994 AW809156 AW806991 AW814082 AW806992 BE061669 AW807002 BE146659 AW806995 AW807000 AW845743 AW845747 AW847504 BE142458 BE061431 BE061435 AW847507 BE146650 BE142470 AW814096 AW807012 BE061438 AW807011 AW806993 BE142465 BE142459 BE142462 AW854330 AW854331 BE061434 BE061731 BE142464 AW847501 AW807001 BE142463 AW811800 BE061437 AW811802 BE061440 AW806997 AW806998 BE061745 BE061753 454560 1223940 1 AW807281 AW807092 AW807425 AW807330 AW807174 AW807171 AW807274 AW807278 AW807367 454651 1228069 1 AW812091 AW812228 AW812106 AW938581 AW812080 454661 1228527_1 BE244133BE244727AW812636AW812647 454738 1232449_1 BE072139BE157977BE157974AW857974AW817778 454754 1233580_1 AW819191 AW819252 AW819183 AW819175 AW819177 AW819186 AW819180 BE158470 AW819242 AW819269 AW819244 AW819190 AW819265 AW819268 AW819246 BE152602 AW819249 AW819251 AW819263 AW819194 454790 1234752 1 AW820852AW820773AW821088 454869 1238137_1 AW836004 AW836087 AW836163AW836162 AW836085 AW836084 AW836079 AW836083 AW836082 AW836086AW836088 AW836166 AW836164 AW836002 AW836078 AW836161 AW862135 AW836165 AW836003 455175 1257335_1 AW993247 AW861464 455400 1288135 1 AW936342 AW936366 455479 1293163_1 AW948312 AW948286 AW948289 AW948297 AW948279 AW948295 455541 1323705_1 AW993005 AW993285 AW993290 455753 13560701 BE075124BE075229BE075278 455826 1373392 1 BE144228 BE144291 458147 488021 1 AW752597 AW848781 AW849062 AW848490 AW752699 AW752604 AW752700 459185 922823_1 AI908222 AI908224 AI908217 TABLE 44C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this cotumn are Genbank identifier (GI) numbers.'Dunham, et al. refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. NLposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt. position 400749 7331445 Minus 9162-9293 400803 8567875 Minus 18267-19088 400917 7283186 Minus 173258-173631 400938 7652890 Minus 92074-92423 40tO75 3687273 Plus 81218-81395 401514 7622355 Plus 93224-93292, 949t95065. 95163-95334 401775 9966311 Minus 110228-110340 401989 4309964 Minus 118611-118821 401992 4153858 Plus 31452-31649 402015 7417802 Minus 48791-49043, 50038-50205, 51530-51672, 54448-54565, 55933-56073 402449 9796674 Plus 59867-60039, 62588-62828, 6346563623, 64923-65108 402466 9796919 Plus 57659-57866, 58839-58908 402759 9213869 Plus 134117-134281 402760 9213869 Plus 136829-136952. 137336-137521 402851 9650753 Minus 63022-63136, 63683-63783 403059 8954192 Minus 69553-69702 403279 8072597 Plus 162569-162768, 163918-164168 403429 9719566 Minus 52789-52917 403670 7259739 Minus 88377-88537 403680 7331517 Minus 157184-157415 403710 6437516 Plus 27413-28978 404121 9796219 Plus 59256-59401 404519 8152000 Plus 12817-13000 404629 9796665 Plus 55584-55796 404973 3213020 Plus 101602-102591 405110 8096888 Minus 118940-119100 405273 4156137 Minus 98141-98754 405645 4926864 Minus 92231-92380, 92724-92869 405742 7283744 Minus 54424-55488

405817 4071056 Plus 19914-20112, 25655-25810 406014 6758904 Minus 23738-24076 406036 6758919 Plus 17942-18163 406109 9127147 Minus 58328-58485 406255 7417729 Plus 2959-3200 406326 9212385 Plus 84508-84655 406600 8248616 Minus 36296-36610 TABLE 45A : ABOUT 947 GENES UP-REGULATED IN STOMACH CANCER COMPARED TO NORMAL ADULT TISSUES Table 45A lists about 947 genes up-regulated in stomach cancer compared to normal adult tissues. These were selected from 59680 probesets on the Affymet ix/Eos Hu03 GeneChip array such that the ratio of'average'stomach cancer to'average'normal adult tissues was greater than or equal to 2. 5. The'average'stomach cancer level was set to the 90th percentage amongst various stomach cancers. The'average'normal adult tissue level was set to the 90th percentage amongstvaious non-måignant Ussues. In order to remove gene-specific background levels of non-specific hybridization, the 15th percenGle value amongst various non-malignant Gssues was subtracted from both the numerator and the denominator before the ratio was evaluated. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of stomach cancer compared to normal stomach Pkey ExAccn UnigenelD Unigene Title R1 418007 M13509 Hs. 83169 matrix metalioproteinase i (interstitial 66. 80 411243 AB039886 Hs. 69319 CA11 61. 16 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin 42. 36 427585 D31152 Hs. 179729 coUagen, bpe X apha 1 (Schmid metaph 35. 80 425679 X05997 Hs. 159177 lipase, gastric 28. 34 409041 AB033025 Hs. 50081 KIAAL 199 protein 26. 91 452121 NM004081 Hs. 70936 deleted in azoospermia 26. 22 403776 NA 25. 00 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act 23. 90 422956 BE545072 Hs. 122579 hypothetical protein FLJ10461 23. 90 409187 AF154830 Hs. 50966 carbamoyi-phosphatesynthetasel. mitoeh 23. 35 424252 AK000520 Hs. 143811 hypothetical protein FU20513 22. 26 439759 AL359055 Hs. 67709 Homo sapiens mRNA full length insert cDN 21. 06 415989 A1267700 Hs. 317584 ESTs 20. 72 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h 19. 84 452401 NM007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 15. 50 438639 A1278360 Hs. 31409 ESTs 15. 16 426427 M86699 Hs. 169840 TTK protein kinase 14. 54 449032 AA045573 Hs. 22900 nuclearfactor (erythroid-derived2)-lik 14. 26 443211 A1128388 Hs. 143655 ESTs 14. 22 421470 R27496 Hs. 1378 annexinA3 13. 96 400792 AA635062 Hs. 50094 Homo sapiens mRNA ; cDNA DKFZp43400515 (f 13. 94 424086 A1351010 Hs. 102267 lysyl oxidase 13. 73 437789 Ai581344 Hs. 127812 ESTs, Weakly similar to T17330 hypotheti 13. 38 409757 NM001898 Hs. 123114 cystatin SN 13. 33 447033 A1357412 Hs. 157601 ESTs 13. 20 447164 AF026941 Hs. 17518 Homo sapiens cig5 mRNA, partial sequence 12. 80 420159 A1572490 Hs. 99785 Homo sapiens cDNA : FLJ21245 fis, clone C 12. 66 432596 AJ224741 Hs. 278461 matri) 3 12. 64 424905 NM 002497 Hs. 153704 NIMA (never in mitosis gene a)-related k 12. 46 413582 AW295647 Hs. 71331 hypothetical protein MGC5350 12. 32 423020 AA383092 Hs. 1608 replication protein A3 (14kD) 12. 18 448693 AW004854 Hs. 228320 hypothetical protein FU23537 11. 74 442660 AW138174 Hs. 130651 ESTs 11. 73 441693 AA384673 Hs. 7943 RPB5-mediating protein 11. 16 450221 AA328102 Hs. 24641 cytoskeleton associated protein 2 11. 08 414142 AW368397 Hs. 150042 Homo sapiens cDNA FW 14438 fis, clone HE 10. 90 424717 H03754 Hs. 152213 wingless-type MMTV integration site fami 10. 48 443715 A1583187 Hs. 9700 cyclin E1 10. 44 420900. AL045633 Hs. 44269 ESTs 10. 38 453922 AF053306 Hs. 36708 budding uninhibited by benzimidazoles 1 10. 36 415076 NM000857 Hs. 77890 guanyiatecyclase1, soluble, beta3 10. 20 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7, S. cerevisi 10. 18 410566 AA373210 Hs. 43047 Homo sapiens CDNA FU13585 fis, clone PL 10. 14 414422 AA147224 Hs. 337232 ESTs 10. 12 409269 AA576953 Hs. 22972 hypothetical protein FLJ13352 10. 02 414972 BE263782 Hs. 77695 KIAAOODB gene product 10. 02 418882 Nom-004996 Hs. 89433 ATP-binding cassette, sub-family C (CFTR 9. 80 428365 AA295331 Hs. 183861 HomosapienscDNAFLJ20042fis, cloneCO 9. 72 416661 AA634543 Hs. 79440 IGF-II mRNA-binding protein 3 9. 68 400195 NA NA 9. 66 418738 AW388633 Hs. 6682 solute carrier family 7, (cationic amino 9. 64 420170 U43374 Hs. 95631 Human normal keratinocyte mRNA 9. 60 414259 W44633 Hs. 301296 Homo sapiens cDNA FU23131 fis, clone L 9. 58 417517 AF001176 Hs. 82238 POP4 (processing of precursor, S. cerev 9. 34 446998 N99013 Hs. 16762 Homo sapiens mRNA ; cDNA DKFZp56482062 (f 9. 26 429486 AF155827 Hs. 203963 hypothetical protein FLJ10339 9. 16 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 8. 95 431810 X67155 Hs. 270845 kinesin-like 5 (mitotic kinesin-like pro 8. 84 419261 X07876 Hs. 89791 wingless-type MMTV integration site fami 8. 80 425921 NM_007231 Hs. 162211 solutecanierfami'y6 (neurotransmiñe 8. 78

424834 AK001432 Hs. 153408 Homo sapiens cDNA FW10570 fis, clone NT 8. 69 413268 AL039079 Hs. 75256 regulator of G-protein signalling 1 8. 68 417801 AA417383 Hs. 82582 integrin, beta-like 1 (with EGF-like rep 8. 68 452461 N78223 Hs. 108106 transcription factor 8. 68 425916 NM006786 Hs. 162200 urotensin 2 8. 64 422805 AA436989 Hs. 121017 H2A histone family, member A 8. 54 438394 BE379623 Hs. 27693 pepfidylprolyl isomerase (cyclophilin)-l 8. 52 441377 BE218239 Hs. 202656 ESTs 8. 41 445891 AW391342 Hs. 199460 ESTs 8. 31 408771 AW732573 Hs. 47584 potassium voltage-gated channel, delayed 8. 30 439521 A1808955 Hs. 58248 ESTs 8. 30 425087 R62424 Hs. 126059 ESTs 8. 28 424653 AW977534 Hs. 151469 calcium/calrtrodulin-dependent serine prot 8. 22 441795 N58115 Hs. 21137 AD024 protein 8. 02 427878 C05766 Hs. 181022 CGI-07 protein 8. 00 413583 AL120806 Hs. 5888 ESTs 7. 98 407853 AA336797 Hs. 40499 dickkopf (Xenopus laevis). homolog 1 7. 98 426269 H15302 Hs. 168950 Homo sapiens mRNA ; cDNA DKFZp566A1046 (f 7. 97 404996 NA 7. 96 400289 X07820 Hs. 2258 matrix metalloproteinase 10 (stromelysin 7. 96 410044 BE566742 Hs. 58169 highly expressed in cancer, rich in leuc 7. 94 417655 AA780791 Hs. 14014 hypothetical protein FLJ14813 7. 92 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 7. 91 418895 AA894638 Hs. 14600 ESTs 7. 90 446155 A1553695 Hs. 159422 Homo sapiens cDNA FLJ13997 fis, clone Y7 7. 86 423123 NM012247 Hs. 124027 SELENOPHOSPHATE SYNTHETASE ; Human selen 7. 82 434539 AW748078 Hs. 214410 ESTs, Weakly similar to MUC2_HUMAN MUCIN 7. 80 447505 AL049266 Hs. 18724 Homo sapiens mRNA ; cDNA DKFZp564F093 (fr 7. 72 418763 AK000219 Hs. 88367 hypothetical protein FU20212 7. 70 447289 AW247017 Hs. 36978 melanoma antigen, family A, 3 7. 70 443354 AW970672 Hs. 9247 protein kinase, AMP-activated, alpha 1 c 7. 69 427718 A1798680 Hs. 25933 ESTs 7. 66 434032 AW009951 Hs. 206892 ESTs 7. 60 427738 NM000318 Hs. 180612 peroxisomal membrane protein 3 (35kD, Ze 7. 58 450480 X82125 Hs. 25040 zinc finger protein 239 7. 51 418678 NM 001327 Hs. 167379 cancer/tesúsantigen 7. 49 431494 AA991355 Hs. 298312 hypothetical protein DKQp434A1315 7. 44 452705 H49805 Hs. 246005 ESTs 7. 36 443646 A1085198 Hs. 164226 ESTs 7. 32 425420 BE536911 Hs. 234545 hypothetical protein NUF2R 7. 30 420617 AK001652 Hs. 99423 ATP-dependent RNA helicae 7. 28 421155 H87879 Hs. 102267 lysyl oxidase 7. 24 450715 Al266484 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 7. 24 447254 NM004153 Hs. 17908 origin recognition complex, subunit 1 (y 7. 22 435473 N53550 Hs. 260881 ESTs 7. 20 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 7. 14 449347 AV649748 Hs. 295901 K) AA0493 protein 7. 11 452281 T93500 Hs. 28792 Homo sapiens DNA 1041 fis. done PL 7. 11 408908 BE296227 Hs. 250822 senne/threoninekinaelS 7. 11 408660 AA525775 Hs. 292523 ESTs, Moderately similar to PC4259 feni 7. 10 453688 AW381270 Hs. 194110 hypothetical protein PR02730 7. 02 426890 AA393167 Hs. 41294 ESTs 6. 98 404440 NA 6. 97 426642 AW068223 Hs. 171581 ubiquitin C-terminal hydrolase UCH37 6. 96 431723 AW058350 Hs. 16762 Homo sapiens mRNA ; cDNA DKFZp564B2062 (f 6. 95 413833 Z15005 Hs. 75573 centromere protein E (312kD) 6. 94 426249 F05422 Hs. 168352 nucleoporin-like protein 1 6. 94 441421 AA356792 Hs. 334824 hypothetical protein FU14825 6. 92 400298 AA032279 Hs. 61635 six transmembrane epithelial antigen of 6. 85 423903 M57765 Hs. 1721 intedeukin 11 6. 84 431041 AA490967 Hs. 197955 KIAA0704 protein 6. 74 417256 U94332 Hs. 81791 tumor necrosis factor receptor superfami 6. 74 426921 AA037145 Hs. 172865 cleavage stimulation factor, 3'pre-RNA, 6. 70 407771 AL138272 Hs. 62713 ESTs 6. 69 433393 AF038564 Hs. 98074 itchy (mouse homolog) E3 ubiquibn prote 6. 66 407162 N63855 Hs. 142634 zinc finger protein 6. 64 411343 U77949 Hs. 69563 CDC6 (cell division cycle 6, S. cerevisi 6. 64 427920 Z11502 Hs. 181107 annexin A13 6. 59 450159 A1702416 Hs. 200771 ESTs, Moderately similar to A Chain A, T 6. 58 427401 U20582 Hs. 2149 actin like protein 6. 55 447102 BE167434 Hs. 98471 ESTs, Weakly similar to T18712 hypotheti 6. 54 431806 AF186114 Hs. 270737 tumor necrosis factor (ligand) superfami 6. 54 435159 AA668879 Hs. 116649 ESTs 6. 54 440209 H05049 Hs. 22269 neurexin 3 6. 54 418134 AA397769 Hs. 86617 ESTs 6. 50 451807 W52854 Hs. 27099 hypothetical protein FLJ23293 similar to 6. 47 434894 AW977850 Hs. 23856 hypothetical protein MGC5297 6. 40 422505 AL120862 Hs. 124165 ESTs 6. 34 426010 AA136563 Hs. 1975 hypothetical protein FLJ21007 6. 32 414696 AF002020 Hs. 76918 Niemann-Pick disease, type C1 6. 31 408380 AF123050 Hs. 44532 diubiquitin 6. 31 420218 AW958037 Hs. 286 ribosomal protein L4 6. 29 405817 NA NA 6. 28

406747 A1925153 Hs. 217493 annexin A2 6. 24 448743 AB032962 Hs. 21896 KIAA1136 protein 6. 24 434636 AA083764 Hs. 6101 hypothetical protein MGC3178 6. 20 424602 AK002055 Hs. 151046 hypothetical protein FLJ11193 6. 17 412661 N32860 Hs. 24611 ESTs. Weakly similar to 154374 gene NF2 6. 17 401644 NA 6. 16 423248 AA380177 Hs. 125845 ribulose-Sphosphate-3-epimerae 6. 13 427335 AA448542 Hs. 251677 G antigen 78 6. 12 450375 AA009647 Hs. 8850 a disintegnn and metalloproteinase doma 6. 07 422420 U03398 Hs. 1524 turnor necrosis factor (ligand) superfami 6. 06 419752 AA249573 Hs. 152618 ESTs. Moderately similar to ZN91HUMANZ 6. 06 413573 Api733859 Hs. 149089 ESTs 6. 06 408758 NM_003686 Hs. 47504 exonuclease 1 6. 02 444188 Api393165 Hs. 699 pepbdylprolyl isomerase 8 (cyclophilin 6. 02 407746 AK001962 Hs. 38114 hypothetical protein FW11100 6. 00 446364 AB006624 Hs. 14912 KIAA0286 protein 5. 98 418939 AW630803 Hs. 89497 lamin 81 5. 90 424639 Api917494 Hs. 9812 Homo sapiens cDNA FU 14388 fis, clone HE 5. 88 434377 AW137148 Hs. 306593 HomosapienscDNAFW11382fis, cloneHE 5. 86 419863 AW952691 Hs. 93485 Homo sapiens mRNA ; cDNA DKFZp761D191 (fr 5. 84 430849 Api940727 Hs. 270556 ESTs. Highly similar to AF156779 1 ASB-4 5. 82 428822 W28418 Hs. 30715 potassium voltage-gated channel, Isk-rel 5. 80 448776 BE302464 Hs. 30057 MRS2 (S. cerevisiae)-like, magnesium hom 5. 74 442957 A1949952 Hs. 49397 ESTs 5. 72 444577 Al207721 Hs. 11393 RAD51 (S. cerevisiae) homolog C 5. 72 424565 AW102723 Hs. 75295 guanylate cyclase 1, soluble, alpha 3 5. 71 433330 AW207084 Hs. 132816 hypothetical protein MGC14801 5. 68 428618 AA885360 Hs. 160199 NADPH oxidase, EF hand calcium-binding d 5. 68 432867 AW016936 Hs. 233364 ESTs 5. 64 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 5. 63 433133 AB027249 Hs. 104741 PDZ-binding kinase ; Tcell originated pr 5. 62 418379 AA218940 Hs. 137516 fidgeUn-like 1 5. 57 434551 BE387162 Hs. 280858 ESTs. Highly similar to A35661 DNA excis 5. 57 442353 BE379594 Hs. 49136 ESTs, Moderately similar to ALU7 HUMAN A 5. 56 427386 AW836261 Hs. 337717 ESTs 5. 54 425650 NM 001944 Hs. 1925 desmogtein 3 (pemphigus vutgaris antigen 5. 52 428479 Y00272 Hs. 184572 cell division cycle 2, G1 to S and G2 to 5. 51 449370 AK002114 Hs. 23495 hypotheticalprotein FLJ11252 5. 50 431118 BE264901 Hs. 250502 carbonic anhydrase Vill 5. 50 423673 BE003054 Hs. 1695 matrix metalloproteinase 12 (macrophage 5. 50 453931 AL121278 Hs. 25144 ESTs 5. 49 409044 AIt29586 Hs. 33033 hypothetical protein FU14623 5. 48 436291 BE568452 Hs. 5101 protein regulator of cytokinesis 1 5. 45 448336 R53848 Hs. 44976 ESTs 5. 44 454018 AW016892 Hs. 100855 ESTs 5. 42 457030 Api301740 Hs. 173381 dihydropyrimidinase-like 2 5. 42 412246 A1160873 Hs. 69233 zinc finger protein 5. 40 432193 AA372264 Hs. 273193 hypothetical protein FLJ 10706 5. 40 437319 BE410958 Hs. 56406 Homo sapiens cDNA FLJ13549 fis, clone PL 5. 40 427660 A1741320 Hs. 114121 HomosapienscDNA : FLJ23228 fis, clone C 5. 40 452862 AW378065 Hs. 8687 ESTs 538 409327 L41162 Hs. 53563 collagen, type IX, alpha 3 5. 36 412811 H06382 Hs. 21400 ESTs 5. 34 448390 AL035414 Hs. 21068 hypothetical protein 5. 32 428187 A1687303 Hs. 285529 G protein-coupled receptor 49 5. 30 450434 AA166950 Hs. 195870 hypothetical protein FU14991 5. 29 434265 AA846811 Hs. 130554 HomosapienscDNA : FLJ23089 fis, clone L 5. 28 407811 AW190902 Hs. 40098 cysteine knot superfamily 1, BMP antagon 5. 27 446638 AL133063 Hs. 15783 Homo sapiens mRNA ; cDNADKFZp434P1115 (f 5. 26 444743 AA045648 Hs. 301957 nudix (nucleoside diphosphate linked moi 5. 25 424902 NM003866 Hs. 153687 inositol polyphosphate-4phosphatase, b 5. 24 452150 W42490 Hs. 260844 ESTs 5. 24 432865 Api753709 Hs. 152484 ESTs, Weakly similar to 138022 hypotheti 5. 24 453382 AA709285 Hs. 5997 hypothetical protein FLJ13078 5. 22 447048 AW393080 Hs. 228320 hypothetical protein FU23537 5. 22 426518 Z43039 Hs. 170198 KIAA0009 gene product 5. 22 453884 AA355925 Hs. 36232 KIAA0186 gene product 5. 20 429625 AA455568 Hs. 193814 ESTs 5. 20 413472 BE242870 Hs. 75379 solute carrier family I (glial high affi 5. 20 449318 AW236021 Hs. 78531 Homosapiens, SimilartoRIKENcDNA5730 5. 19 444059 R69743 Hs. 116774 integrin, alpha1 5. 18 409432 D49372 Hs. 54460 small inducible cytokine subfamily A (Cy 5. 17 412719 AW016610 Hs. 129911 ESTs 5. 15 444342 Mot4398 Hs. 10887 similar to lysosome-associated membrane 5. 14 425739 T19016 Hs. 159410 molybdopterin synthase sulfurylase 5. 12 452198 A1097560 Hs. 6 1210 ESTs, Weakly similar to 138022 hypotheti 5. 12 445657 AW612141 Hs. 279575 Homo sapiens G-protein coupled receptor 5. 10 434699 AA643687 Hs. 149425 Homo sapiens cDNA FW11980 fis, clone HE 5. 09 424296 Al631874 Hs. 155140 casein kinase 2, alpha 1 polypepúde 5. 08 441645 A1222279 Hs. 201555 ESTs, Weakly similar to T23406 hypotheti 5. 06 412723 AA648459 Hs. 335951 hypothetical protein AF301222 5. 06 448811 A1590371 Hs. 174759 ESTs 5. 05 447342 A1199268 Hs. 19322 Homosapiens, SimilartoRIKENcDNA2010 5. 04

411835 U29343 Hs. 72550 hyaiuronan-mediatedmotiiityreceptor (R 5. 04 421373 AA808229 Hs. 167771 ESTs 5. 04 448991 AW771565 Hs. 189594 ESTs 5. 02 429370 C19097 Hs. 89709 glutamate-cysteineligae, modifiersubu 5. 00 454036 AA374756 Hs. 93560 HomosapiensmRNAforKIM1771protein, 4. 98 405770 NA 4. 96 421110 AJ250717 Hs. 1355 cathepsin E 4. 96 452588 AA889120 Hs. 110637 homeo box A10 4. 92 433159 AB035898 Hs. 150587 kinesin-like protein 2 4. 91 420952 AA282067 Hs. 88972 ESTs, ModeratelysimilartoA46010X9in 4. 88 408321 AW405882 Hs. 44205 cortistatin 4. 87 441801 AW242799 Hs. 86366 ESTs 4. 84 450568 AL050078 Hs. 25159 Homo sapiens cDNA FLJ10784 fis, clone NT 4. 83 452909 Nom015368 Hs. 30985 pannexin 1 4. 82 409799 D11928 Hs. 76845 phosphoserine phosphatase-like 4. 82 451105 AI761324 gb : wi60bi il Homo sapiens 4. 80 417168 AL133117 Hs. 81376 HomosapiensmRNA ; CONA DKFZp586LI 121 (f 4. 80 418203 X54942 Hs. 83758 CDC28 protein kinase 2 4. 80 418994 AA296520 Hs. 89546 selectin E (endothelial adhesion molecul 4. 78 436982 AB018305 Hs. 5378 spondin 1, (f-spondin) extræellular mat 4. 78 432874 W94322 Hs. 279651 melanoma inhibitory acivity 4. 78 440351 AF030933 Hs. 7179 RAD1 (S. pombe) homolog 4. 78 431956 AK002032 Hs. 272245 Homo sapiens cDNA FLJ11170 fis, clone PL 4. 77 442980 AA857025 Hs. 8878 kinesin-like 1 4. 76 432437 W07088 Hs. 293685 ESTs 4. 76 414869 AA157291 Hs. 21479 ubinuclein 1 4. 74 446254 BE179829 Hs. 179852 Homo sapiens cDNA FLJ12832 fis, clone NT 4. 74 418380 AA425473 Hs. 84429 KIAA0971 protein 4. 74 419343 AA456245 Hs. 85603 down-regulated by Ctnnbt, a 4. 74 418478 U38945 Hs. 1174 cyclin-dependentkinaeinhibitor2A (me 4. 72 425813 AA364136 Hs. 210553 hypothetical protein DKFZp7611172 4. 71 425071 NM013989 Hs. 154424 deiodinase, iodothyronine, type 11 4. 71 412733 AA984472 Hs. 74554 KIAA0080 protein 4. 68 444325 AW152618 Hs. 16757 ESTs 4. 66 407638 AJ404672 Hs. 334483 hypotheticalprotein FLJ23571 4. 66 430345 AK000282 Hs. 239681 hypotheticalprotein FLJ20275 4. 66 428330 L22524 Hs. 2256 matrix metaloproteinae 7 (matrilysin, 4. 64 449448 D60730 Hs. 57471 ESTs 4. 62 409732 Nu016122 Hs. 56148 NY-REN-58 antigen 4. 62 432415 T16971 Hs. 289014 ESTs. Weakly similar to A43932 mucin 2 p 4. 62 421987 A1133161 Hs. 286131 CGI-101 protein 4. 60 430217 N47863 Hs. 336901 ribosome protein S24 4. 58 429597 NM 003816 Hs. 2442 adisintegrinandmetaitoproteinasedoma 4. 57 425932 M81650 Hs. 1968 semenogelin 1 4. 57 408728 AL137379 Hs. 47125 hypothetical protein FLJ13912 4. 56 428434 AW363590 Hs. 65551 Homo sapiens, Similar to DNA segment. Ch 4. 55 451254 A1571016 Hs. 172967 ESTs 4. 54 422426 W79117 Hs. 58559 ESTs 4. 54 439483 T69980 Hs. 58323 Homo sapiens cDNA FLJt 1613 fis, clone HE 4. 53 435420 A1928513 Hs. 59203 ESTs 4. 53 447519 U46258 Hs. 339665 ESTs 4. 52 424176 AL137273 Hs. 142307 hypothetical protein 4. 52 414812 X72755 Hs. 77367 monokine induced by gamma interferon 4. 51 438069 N80701 Hs. 33790 ESTs 4. 50 450096 A1682088 Hs. 79375 holocarboxylase synthetase (biotin-lprop 4. 50 438159 Z83947 gb : H. sapiensmRNA ; cloneCD117 4. 50 433925 Ai183551 Hs. 26481 SBBI26 protein 4. 48 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 4. 48 433384 A1021992 Hs. 124244 ESTs 4. 47 421863 Api952677 Hs. 108972 Homo sapiens mRNA ; cDNA DKFZp434P228 (fr 4, 47 453941 U39817 Hs. 36820 Bloom syndrome 4. 45 423401 NM001992 Hs. 128087 coagulabon factor 11 (thrombin) recepto 4. 44 430510 AW162916 Hs. 241576 hypothetical protein PR02577 4. 43 424084 Api940675 Hs. 20914 hypothetical protein FU23056 4. 42 459587 AA031956 gb : zk15e04. sl Soares_pregnant_utenus NbH 4. 42 417956 AA210704 Hs. 190465 ESTs 4. 42 449433 Api672096 Hs. 9012 ESTs, Weakly similar to S26650 DNA-bindi 4. 42 421477 Api904743 Hs. 104650 hypothetical protein FU10292 4. 42 406687 M31126 Hs. 272620 pregnancy specific betal-glycoprotein 9 4. 41 451813 Not6117 Hs. 27182 phosphotipaseA2-activatin9protein 4. 41 415091 AL044872 Hs. 77910 3-hydroxy-3methylglutaryl-CoenzymeAsy 4. 40 425142 AW954397 Hs. 154762 HIV-1 rev binding protein 2 4. 40 441720 A1346487 Hs. 28739 ESTs 4. 40 409683 U33317 Hs. 711 defensin, alpha 6, Paneth cell-specific 4. 39 411571 AA122393 Hs. 70811 hypothetical protein FLJ20516 4. 38 430044 AA464510 Hs. 152812 ESTs 4. 37 436246 AW450963 Hs. 119991 ESTs 4. 37 409582 R27430 Hs. 271565 ESTs 4. 37 453652 AW009640 Hs. 28368 ESTs, Moderately similar to S65657 alpha 4. 35 425211 M18667 Hs. 1867 progastricsin (pepsinogen C) 4. 34 448692 AW013907 Hs. 167531 methylcrotonoyl-CoenzymeAcaboxylae2 4. 34 409459 D86407 Hs. 54481 low density lipoprotein receptor-related 4. 34 442470 AW273860 Hs. 5759 ESTs 4. 33

441894 AA134329 Hs. 24170 Homo sapiens, clone IMAGE : 3685398. mRNA. 4. 32 422867 L32137 Hs. 1584 cartilage oligomeric matrix protein (pse 4. 31 436396 AI683487 Hs. 152213 wingless-type MMTV integration site fami 4. 31 433397 AW079766 Hs. 134880 ESTs, Weakly similar to unnamed protein 4. 30 417576 AA339449 Hs. 82285 phosphoribosylglycinamide fonnyltransfer 4. 29 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa 4. 29 451592 A1805416 Hs. 213897 ESTs 4. 28 453900 AW003582 Hs. 226414 ESTs, Weakly similar to ALUB HUMAN ALU S 4. 28 422892 AA988176 Hs. 121553 hypothetical protein FW20641 4. 26 431699 NM001173 Hs. 267831 Rho GTPase activating protein 5 4. 26 428389 AW135714 Hs. 283127 ESTs, Weakly similar to Tl 9201 hypotheu 4. 24 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-4. 23 409913 BE243842 Hs. 283077 centrosomal P4. 1-associated protein ; unc 4. 22 445537 AJ245671 Hs. 12844 EGF-like-domain, mulUple 6 4. 21 445640 AW969626 Hs. 31704 ESTs, Weakly similar to KIAA0227 [H. sapi 4. 20 422232 D43945 Hs. 113274 transcription factor EC 4. 18 442655 AW027457 Hs. 30323 ESTs, Weakly similar to B34087 hypotlheb 4. 18 444381 BE387335 Hs. 283713 ESTs, Weakly similar to S64054 hypothe6 4. 16 434217 AW014795 Hs. 23349 ESTs 4. 16 413384 NM_000401 Hs. 75334 exostoses (mul6ple) 2 4. 14 407768 AW002841 Hs. 29475 ESTs 4. 14 419168 Api336132 Hs. 33718 Homo sapiens cDNAFU12641fs. done NT 4. 13 408165 AL137573 Hs. 43143 Homo sapiens mRNA ; cDNA DKFZpS64A2463 ( 4. 12 443691 A1081724 Hs. 17267 ESTs 4. 12 409640 U78722 Hs. 55481 zinc finger protein 165 4. 12 438176 AW138970 Hs. 122113 ESTs 4. 10 435532 AW291488 Hs. 117305 Homo sapiens, clone IMAGE : 3682908, mRNA 4. 10 419606 AW294795 Hs. 198529 ESTs 4. 08 452824 W27643 Hs. 73965 splicing factor, arginine/serine-rich 2 4. 08 414152 NM 003248 Hs. 75774 thrombospondin 4 4. 08 418688 T85017 Hs. 1192 KIAA0074 protein 4. 07 404253 NA 4. 06 421741 AK001879 Hs. 107527 hypothetica) protein FU11017 4. 06 428218 AA424266 Hs. 123642 EphA3 4. 06 428858 AA436760 gb : zv67d11. r1 Soares total_tetus_Nb2HF8_ 4. 06 428336 AA503115 Hs. 183752 microseminoprotein, beta-4. 05 442875 BE623003 Hs. 23625 Homo sapiens clone TCCCTA00142 mRNA sequ 4. 04 421841 AA908197 Hs. 108850 MAK-related kinase 4. 04 451177 A1969716 Hs. 13034 ESTs 4. 04 425188 AK002052 Hs. 155071 hypothetical protein FW 11190 4. 04 421262 AA286746 Hs. 9343 Homo sapiens cDNA FLJ14265 fis, clone PL 4. 03 424634 NM 003613 Hs. 151407 cartilage intermediate layer protein, nu 4. 02 438777 AA825487 Hs. 142179 ESTs 4. 02 423343 AA324643 Hs. 246106 ESTs 4. 02 425788 BE466417 Hs. 231899 ESTs, Weakly similar to rab3 effector-li 4. 02 409928 AL137163 Hs. 57549 hypotheGcal protein dJ47384 4. 01 406671 AA129547 Hs. 285754 met proto-oncogene (hepatocyte growth fa 4. 01 442973 BE567665 Hs. 288550 Homo sapiens cDNA : FLJ23156 fis, clone L 4. 00 433225 AW816515 Hs. 173540 ATPase. Class V, type 10D 4. 00 411765 H43346 gb : ypO9aO4. ri Scares breast 3NbHBst Homo 4. 00 452022 AW072330 Hs. 293875 ESTs 4. 00 451806 Nom-003729 Hs. 27076 RNA 3'-terminal phosphate cyclase 3. 99 423541 AA296922 Hs. 129778 gastrointestinal peptide 3. 99 414132 A1801235 Hs. 48480 ESTs 3. 99 452453 Api902519 gb : QV-BT009-10119&051 BT009 Homo sapien 3. 98 418454 AA315308 Hs. 195870 hypothetical protein FLJ14991 3. 98 430134 BE380149 Hs. 105223 ESTs. Weakly similar to T33188 hypotheti 3. 98 453160 AI263307 Hs. 239884 H2Bhistonefamily, member L 3. 97 417235 AA810278 Hs. 24250 ESTs 3. 96 425398 AL049689 Hs. 156369 hypothetical protein similar to tenascin 3. 95 414136 AA812434 Hs. 119023 SMC2 (structural maintenance of chromoso 3. 94 436608 AA628980 Hs. 192371 down syndrome critical region protein DS 3. 94 431753 X76029 Hs. 2841 neuromedin U 3. 94 453161 AA628608 Hs. 61656 ESTs 3. 94 454821 AW833504 gb : QV4-TT0008-091199-025-f03TT0008Homo 3. 94 427961 AW293165 Hs. 143134 ESTs 3. 94 439453 BE264974 Hs. 6566 thyroid hormone receptor interactor 13 3. 93 409564 AA045857 Hs. 54943 fracture callus 1 (rat) homolog 3. 93 418396 A1765805 Hs. 26691 ESTs 3. 92 451411 AA017492 Hs. 135655 EST 3. 92 445885 A1734009 Hs. 127699 KIAA1603 protein 3. 92 407698 AA058900 Hs. 32646 hypothetical protein FLJ21901 3. 91 442896 R37725 Hs. 261108 ESTs 3. 90 433361 AW469373 Hs. 300141 ribosoma) protein L39 3. 90 419926 AW900992 Hs. 93796 DKFZP58602223 protein 3. 89 413775 AW409934 Hs. 75528 nucleolar GTPase 3. 88 452943 BE247449 Hs. 31082 hypothetical protein FU10525 3. 86 428549 AA430064 Hs. 220929 Homo sapiens cDNA FLJ14369 fis, clone HE 3. 86 456120 AA535244 Hs. 78305 RAB2, member RAS oncogene family 3. 86 452194 Api694413 Hs. 332649 olfactay receptor, family 2, subfamily 3. 85 421247 BE391727 Hs. 102910 general transcription factor IIH, polype 3. 85 417720 AA205625 Hs. 208067 ESTs 3. 85 418811 AK001407 Hs. 88663 hypothetical protein FUI0545 3. 84

430899 BE018217 Hs. 183528 hypothetical protein FU14906 3. 84 421246 AW582962 Hs. 102897 CGI-47 protein 3. 83 407366 AF026942 gb : Homo sapiens cig33 mRNA, partial sequ 3. 83 428698 AA852773 Hs. 334838 KIAA1866 protein 3. 82 435202 A1971313 Hs. 170204 KIAA0551 protein 3. 82 454074 R63503 Hs. 28419 ESTs 3. 82 448917 Al683598 Hs. 201615 ESTs 3. 82 410507 AA355288 Hs. 40834 transitional epithelia response protein 3. 82 452571 W31518 Hs. 34665 ESTs 3. 82 445663 A1247343 Hs. 149232 ESTs 3. 82 450701 H39960 Hs. 288467 Homo sapiens cDNA FU 12280 fis, clone MA 3. 80 423025 AA831267 Hs. 12244 hypothetical protein FU20097 3. 80 425656 AB018284 Hs. 158688 KIAA0741 gene product 3. 80 407168 R45175 Hs. 117183 ESTs 3. 79 403422 NA NA 3. 79 425492 AL021918 Hs. 158174 zinc finger protein 184 (Kruppel-like) 3. 79 432239 X81334 Hs. 2936 matrix metalloproteinase 13 (collagenase 3. 79 457325 AA744550 Hs. 136345 ESTs 3. 78 433800 A1034361 Hs. 135150 lung type-I cell membrane-associated gly 3. 77 428865 BE544095 Hs. 164960 BarH-like homeobox 1 3. 76 424188 AW954552 Hs. 142634 zinc finger protein 3. 75 424638 Ai472106 Hs. 49303 Homo sapiens cDNA FLJ11663 fis, clone HE 3. 75 451099 R52795 Hs. 25954 intedeukin 13 receptor, alpha 2 3. 75 448105 AW591433 Hs. 298241 Transmembrane pnotease, serine 3 3. 74 452785 AL359942 Hs. 296434 erythroid differentiation and denudeati 3. 74 459000 AA903705 Hs. 4190 HomosapienscDNA FW23269fis, cloneC 3. 74 432653 N62096 Hs. 293185 ESTs, Weakly similar to JC7328 amino aci 3. 73 409632 W74001 Hs. 55279 serine (orcysteine) proteinaseinhibito 3. 73 414883 AA926960 Hs. 334883 CDC28 protein kinase 1 3. 73 415064 AA159804 Hs. 149305 hypothetical protein MGC2603 3. 72 432198 A1475306 Hs. 50458 ESTs 3. 72 458194 AW383618 Hs. 265459 ESTs, Moderately similar to ALU2-HUMAN A 3. 72 415263 AA948033 Hs. 130853 ESTs 3. 71 408296 AL117452 Hs. 44155 DKFZP586G1517protein 3. 71 408460 AA054726 Hs. 285574 ESTs 3. 71 437496 AA452378 Hs. 170144 Homo sapiens mRNA ; cDNA DKFZp547J125 (fr 3. 70 443486 NM003428 Hs. 9450 zinc finger protein 84 (HPF2) 3. 68 432021 AA524470 Hs. 58753 ESTs 3. 68 420092 AA814043 Hs. 88045 ESTs 3. 68 414923 AW445008 Hs. 77637 homeo box A4 3. 68 429432 A1678059 Hs. 202676 synaptonemal complex protein 2 3. 68 435496 AW840171 Hs. 265398 ESTs, Weakly similar to transformation-r 3. 67 430544 AA481066 Hs. 105153 Homo sapiens, clone IMAGE : 3461987, mRNA, 3. 67 432542 AW083920 Hs. 16098 claudin 2 3. 67 410782 AW504860 Hs. 288836 hypothetical protein FLJ12673 3. 66 421106 AA877124 Hs. 172844 ESTs 3. 64 439107 AL046134 Hs. 13944 adrenergic, beta, receptor kinase 2 3. 64 418735 N48769 Hs. 44609 ESTs 3. 64 411598 BE336654 Hs. 70937 H3 histone family, member A 3. 63 424687 J05070 Hs. 151738 matrix metalloproteinase 9 (gelatinase 8 3. 63 436411 AW674352 gb : ba63c07. yl NIH_MGC_12 Homo sapiens cD 3. 63 429774 Api522215 Hs. 50883 KIAA1804 protein 3. 62 448844 A1581519 Hs. 177164 ESTs 3. 61 402473 AB033035 Hs. 51965 KIAA1209 protein 3. 61 441085 AW136551 Hs. 181245 Homo sapiens CDNA FU12532 fis, clone NT 3. 61 429534 AW976987 Hs. 163327 ESTs, Weakly similar to 2109260A 8 cell 3. 60 414706 AW340125 Hs. 76989 KIAA0097 gene product 3. 60 436211 AK001581 Hs. 334828 hypotheticaproteinFW10719 ; KIM1794 359 422938 NM001809 Hs. 1594 centromere protein A (17kD) 3. 59 451381 BE241831 Hs. 172330 hypothetical protein MGC2705 3. 58 428664 AK001666 Hs. 189095 similartoSALL1 (så (Drosophilaplike 3. 58 424345 AK001380 Hs. 145479 Homo sapiens cDNA FLJ10518 fis, clone NT 3. 58 440717 AA904527 Hs. 42207 ESTs 3. 58 450698 W31489 Hs. 95044 ESTs. Weakly similar to 138022 hypotheti 3. 58 423675 Api990509 Hs. 131342 small inducible cytokine subfamily A (Cy 3. 58 424882 A) 379461 Hs. 153636 far upstream element (FUSE) binding prot 3. 57 410784 AW803201 gb : IL2-UM0077-070500-080-E06 UM0077 Homo 3. 55 411096 U80034 Hs. 68583 mitochondria) intermediate peptidase 3. 55 430294 A1538226 Hs. 32976 guanine nucleotide binding protein 4 3. 54 439225 AA192669 Hs. 45032 ESTs 3. 54 429183 AB014604 Hs. 197955 KIAA0704 protein 3. 54 419948 AB041035 Hs. 93847 NADPHoxidase4 3. 53 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 3. 52 408556 U49516 Hs. 46362 5-hydroxytryptamine (serotonin) receptor 3. 52 417048 A1088775 Hs. 55498 geranylgeranyl diphosphate synthase 1 3. 52 432101 A1918950 Hs. 123642 EphA3 3. 52 419216 AU076718 Hs. 164021 small inducible cytoldne subfamily B (Cy 3. 51 444754 T83911 Hs. 11881 transmembrane 4 superfamily member 4 3. 51 422093 AF151852 Hs. 111449 CGI-94protein 3. 50 404766 NA NA 3. 50 441513 AW014557 Hs. 112420 ESTs 3. 50 444301 AK000136 Hs. 10760 asponn (LRRclas 1) 3. 50 417315 Al030042 Hs. 336901 ribosomal protein S24 3. 50

407182 AA312551 Hs. 230157 ESTs 3. 49 443204 AW205878 Hs. 29643 Homo sapiens cDNA FU 13103 fis, clone NT 3. 49 432289 A1860145 Hs. 55118 ESTs 3. 49 453644 A1813444 Hs. 42197 ESTs 3. 48 427986 N45214 Hs. 282387 Homo sapiens cDNA : FLJ21837 fis, clone H 3. 48 405466 NA 3. 48 410804 U64820 Hs. 66521 Machado-Joseph disease (spinocerebellar 3. 48 430357 AW976789 Hs. 165607 ESTs 3. 46 418428 Y12490 Hs. 85092 thynoidhomloneraeptorinterætor11 3. 46 422260 AA315993 Hs. 105484 regenerating gene type IV 3. 46 421928 AF013758 Hs. 109643 polyadenylate binding protein-interactin 3. 46 451403 AA885569 Hs. 40919 Homo sapiens cDNA FLJ14511 fis, clone NT 3. 46 406117 NA 3. 46 458242 BE299588 Hs. 28465 Homo sapiens cDNA : FU21869 fis, clone H 3. 46 408562 Api436323 Hs. 31141 Homo sapiens MRNA for KIAAL 568 protein, 3. 45 440105 AA694010 Hs. 6932 Homo sapiens clone 23809 mRNA sequence 3. 45 443767 BE562136 Hs. 9736 proteasome (prosome. macropain) 26S subu 3. 45 426320 W47595 Hs. 169300 transforming growth factor, beta 2 3. 45 444478 W07318 Hs. 240 M-phase phosphoprotein 1 3. 45 425904 A1805990 Hs. 82238 POP4 (processing of precursor, S. cerev 3. 44 416702 AA186428 Hs. 85591 ESTs 3. 44 448668 A1560305 Hs. 199852 ESTs 3. 42 410004 A1298027 Hs. 5057 carboxypepúdase D 3. 42 428771 AB028992 Hs. 193143 KIAA1069 protein 3. 42 446619 AU076643 Hs. 313 secreted phosphopnotein 1 (osteopontin, 3. 42 429628 H09604 Hs. 13268 ESTs 3. 40 448816 AB033052 Hs. 22151 KIAA1226 protein 3. 40 456032 AW957446 Hs. 301711 ESTs 3. 39 439635 AA477288 Hs. 94891 hypothetical protein FW22729 3. 39 414275 AW970254 Hs. 889 Charot-Leyden crystal protein 3. 38 447207 AA442233 Hs. 17731 hypothetical protein Flot2892 3. 38 416057 A1927382 Hs. 29857 ESTs 3. 38 430704 AW813091 Hs. 335799 ESTs 3. 38 423600 A1633559 Hs. 310359 ESTs 3. 38 453891 AB037751 Hs. 36353 Homo sapiens mRNA full length insert cDN 3. 38 430178 AW449612 Hs. 152475 ESTs 3. 37 417791 AW965339 Hs. 111471 ESTs 3. 37 408867 AA437199 Hs. 656 cell division cycle 25C 3. 37 449802 AW901804 Hs. 23984 hypothetical protein FLJ20147 3. 37 457003 S78234 Hs. 172405 cell division cycle 27 3. 36 458076 R80061 Hs. 164478 hypothetical protein FLJ21939 similar to 3. 36 436203 BE384982 Hs. 5076 Homo sapiens cDNA : FU22128 fis, clone H 3. 36 418782 A1792648 Hs. 14665 ESTs 3. 34 449722 BE280074 Hs. 23960 cyclin B1 3. 34 447984 A1457263 Hs. 37244 ESTs 3. 34 451103 R52804 Hs. 25956 DKFZP564D206 protein 3. 34 408812 BE397160 Hs. 254763 ESTs, Weakly similar to A42442 integrin 3. 34 448305 AA625207 Hs. 264915 Homo sapiens DNA 12908fis. done NT 3. 34 418849 AW474547 Hs. 53565 HomosapiensPIG-MmRNAformannosyltran 3. 33 450531 AW301032 Hs. 203800 ESTs 3. 32 411263 BE297802 Hs. 69360 kinesin-like6 (mitoUccentromere-assoc 3. 32 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) 3. 31 425746 NM 001701 Hs. 159440 bile acid Coenzyme A : amino acid N-acylt 3. 30 421037 A1684808 Hs. 197653 ESTs 3. 30 430388 AA356923 Hs. 240770 nuclear cap binding protein subunit 2, 2 3. 30 433132 AB026264 Hs. 284245 hypothetical protein IMPACT 3. 30 447078 AW885727 Hs. 301570 ESTs 3. 30 402408 NA NA 3. 29 437044 AL035864 Hs. 69517 cDNA for differentially expressed C016 g 3. 29 423126 AA322245 Hs. 290165 ESTs 3. 28 446223 BE300091 Hs. 119699 hypothetical protein FLJ12969 3. 27 451917 AW391351 Hs. 50820 HomosapiensunknownmRNA 3. 27 419335 AW960146 Hs. 284137 hypothetical protein FLJ12888 3. 26 411078 AI222020 Hs. 182364 CocoaCrisp 3. 26 419790 U79250 Hs. 93201 glycerol-3-phosphate dehydrogenase 2 (mi 3. 26 427119 AW880562 Hs. 114574 ESTs 3. 26 400250 NA NA 3. 26 429044 A1261490 Hs. 145527 ESTs 3. 25 451050 AW937420 Hs. 69662 ESTs 3. 24 447425 A1963747 Hs. 18573 acyiphosphatae 1, erythrocyte (common) 3. 24 410389 AW954049 Hs. 8177 ESTs, Weakly similar to PIHUB6 salivary 3. 23 416565 AW000960 Hs. 44970 endoptasmicreticuium resident protein 5 3. 22 442028 A1239437 Hs. 48945 ESTs 3. 22 409110 AA191493 Hs. 48778 niban protein 3. 22 418926 AA232658 Hs. 105794 UDP-glucose : glycoprotein glucosyltransfe 3. 22 408353 BE439838 Hs. 44298 mitochondrial dbosomal protein S17 3. 21 445417 AK001058 Hs. 12680 Homo sapiens cDNA FW 10196 fis, clone HE 3. 20 442979 AW440782 Hs. 174743 ESTs 3. 20 439292 AA090421 Hs. 5555 hypothetical protein MGC5347 3. 20 440953 A1683036 Hs. 124135 HomosapienscDNAFW13051 fis, cloneNT 3. 20 447020 T27308 Hs. 16986 hypothetical protein FLJ11046 3. 20 451181 A1796330 Hs. 207461 ESTs 3. 19 422809 AK001379 Hs. 121028 hypothetical protein Fou10549 3. 19

411573 AB029000 Hs. 70823 KIAA1077 protein 3. 19 424539 L02911 Hs. 150402 activin A receptor, type 1 3. 18 443179 AI928402 Hs. 6933 hypothetical protein FLJ12684 3. 18 452545 N31940 Hs. 14434 ESTs, Weakly similar to 138022 hypotheti 3. 18 433024 AA573847 Hs. 26549 KIAA1708 protein 3. 18 414737 Al160386 Hs. 125087 ESTs 3. 18 444230 H95537 Hs. 146067 ESTs 3. 18 419741 NM_007019 Hs. 93002 ubiquitin carrier protein E2-C 3. 17 428945 AW192803 Hs. 98974 ESTs, Weakly similar to S65824 reverse t 3. 17 424085 NM 002914 Hs. 139226 replication factor C (activator 1) 2 (40 3. 17 418661 NM001949 Hs. 1189 E2F transcription factor 3 3. 17 443598 AW499970 Hs. 14822 ESTs, Weakly similar to 178885 serinelth 3. 16 413516 BE145907 gb : MRO-HT0208-221299-204-el2 HT02û8 Homo 3. 16 434389 AA971235 Hs. 128098 ESTs 3. 16 431322 AW970622 gb : EST382704 MAGE resequences, MAGK Homo 3. 15 432158 W33165 Hs. 22983 UDP-glucose : glycoprotein glucosyltransfe 3. 15 453331 A1240665 Hs. 8895 ESTs 3. 15 410286 Api739159 Hs. 61898 DKFZP586N2124protein 3. 14 408687 AL110280 Hs. 301152 Homo sapiens mRNA ; cDNA DKFZp434F053 (fr 3. 14 422789 AK001113 Hs. 120842 hypothetical protein FLJ10251 3. 14 419078 M93119 Hs. 89584 insulinoma-associated 1 3. 14 414080 AA135257 Hs. 47783 8 aggressive lymphoma gene 3. 14 451525 AW001757 Hs. 14005 ESTs 3. 13 453775 NM 002916 Hs. 35120 replication factor C (activator 1) 4 (37 3. 13 433183 AF231338 Hs. 222024 transcription factor BMAL2 3. 12 424783 AA913909 Hs. 153088 TATA box binding protein (TBP)-associate 3. 12 413170 BE068819 gb : MRO-BT0374-220300-001-bO3 BT0374 Homo 3. 12 437181 A1306615 Hs. 125343 ESTs, Weakly similar to KIAA0758 protein 3. 12 442991 BE281238 Hs. 8886 hypothetical protein FU20424 3. 11 453867 A1929383 Hs. 33032 hypothetica protein DKFZp434N185 3. 11 437641 AA811452 Hs. 291911 ESTs 3. 10 428651 AF196478 Hs. 188401 annexin A10 3. 09 427927 Api879165 Hs. 2227 CCAAT/enhancer binding protein (C/EBP), 3. 09 419196 AF110908 Hs. 297660 TNF receptor-associated factor 3 3. 09 414569 AF109298 Hs. 118258 prostate cancer associated protein 1 3. 09 408633 AW963372 Hs. 46677 PR02000 protein 3. 09 403381 NA 3. 08 444619 BE538082 Hs. 8172 ESTs, Moderately similar to A46010 X-lin 3. 08 422363 T55979 Hs. 115474 replication factor C (activator 1) 3 (38 3. 08 434138 AA625804 gb : zu86hO1. sl Soares_tesús_NHTHomosap 3. 07 425322 U63630 Hs. 155637 protein kinase, DNA-activated, catalytic 3. 07 436556 A1364997 Hs. 7572 ESTs 3. 07 427043 AA397679 Hs. 3991 ESTs 3. 06 443055 AV653742 Hs. 15536 hypotheticalprotein DKFZp761J139 3. 06 419229 A1827237 Hs. 282884 ESTs 3. 05 414718 H95348 Hs. 107987 ESTs 3. 05 439737 AI751438 Hs. 41271 HomosapiensmRNAhulilengthinsertcDN 3. 05 448587 A1539652 Hs. 28338 KIM1546 protein 3. 04 448595 AB014544 Hs. 21572 KIAA0644 gene product 3. 04 407201 N31998 Hs. 164256 hypothetical protein FU20657 3. 04 423065 R96158 Hs. 267130 Homo sapiens, clone MGC : 5406, mRNA, comp 3. 04 431980 AA523696 Hs. 324507 hypothetical protein FU20986 3. 04 416198 H27332 Hs. 99598 hypothetical protein MGC5338 3. 04 429410 X98494 Hs. 201676 M-phasephosphoprotein10 (U3smallnucl 3. 04 432140 AK000404 Hs. 272688 hypothetical protein FU20397 3. 03 441031 Al110684 Hs. 7645 fibrinogen, B beta polypepUde 3. 03 446142 Api754693 Hs. 145968 ESTs 3. 02 402167 NA 3. 02 402299 NA 3. 02 417830 AW504786 Hs. 122579 hypothetical protein FW10461 3. 02 419910 AA662913 Hs. 190173 ESTs, Weakly similar to A46010 X-linked 3. 02 424001 W67883 Hs. 137476 paternally expressed 10 3. 01 413930 M86153 Hs. 75618 RAB11A, member RAS oncogenefamily 3. 01 439924 A1985897 Hs. 125293 ESTs 3. 01 414343 AL036166 Hs. 323378 coated vesicle membrane protein 3. 01 432201 A1538613 Hs. 298241 Transmembrane protease, serine 3 3. 00 445845 A1261870 Hs. 145555 ESTs 3. 00 420727 H75701 Hs. 99886 complement component 4-binding protein, 3. 00 427510 Z47542 Hs. 179312 smalnuclearRNAæUvaúngcomplex, po 3. 00 403637 NA NA 3. 00 410947 AK000305 Hs. 67055 hypothetical protein FU20298 3. 00 413430 R22479 Hs. 167073 Homo sapiens cDNA FW13047 fis, clone NT 3. 00 423575 C18863 Hs. 163443 HomosapienscDNAFW11576fis, cloneHE 2. 99 426711 AA383471 Hs. 180669 conserved gene amplified in osteosarcoma 2. 99 442204 Al635450 Hs. 21914 ESTs 2. 98 429682 NM_006306 Hs. 211602 SMC1 (structural maintenance of chromoso 2. 98 419227 BE537383 Hs. 89739 cholinergic receptor, nicotinic, beta po 2. 97 447233 AW246333 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 2. 97 441826 AW503603 Hs. 129915 phosphotriesterase related 2. 97 433404 T32982 Hs. 102720 ESTs 2. 96 450506 NM 004460 Hs. 418 fibroblasl activation protein, alpha 2. 96 423880 BE278111 Hs. 134200 DKFZP564C186 protein 2. 96 411750 BE562298 Hs. 71827 KIAA0112 protein ; homolog of yeast ribos 2. 96

408155 AB014528 Hs. 43133 KIAA0628 gene product 2. 96 424131 AA335714 Hs. 199665 ESTs 2. 96 451250 AA491275 Hs. 236940 hypothetcal protein FU 12542 2. 96 425154 Nom001851 Hs. 154850 collagen, type IX, alpha 1 2. 96 447829 A1433029 Hs. 164104 ESTs 2. 95 410561 BE540255 Hs. 6994 Homo sapiens cDNA : FW22044fis cloneH 2. 95 417873 BE266659 Hs. 293659 Homosapiens SimilartoRIKENcDNAA430 2. 95 452693 T79153 Hs. 48589 zinc finger protein 228 2. 95 407742 AF186252 Hs. 38084 sulfotransferaefamily cytosoWic 1C 294 421430 AW207555 Hs. 97093 Homo sapiens cDNA : FLJ23004 fis, clone L 2. 94 407995 A1094748 Hs. 100134 hypotheticalprotein FLJ12787 2. 94 413281 AA861271 Hs. 222024 transcriptionfactorBMAL2 2. 94 452381 H23329 Hs. 290880 ESTs WeaklysimilartoALU1 HUMANALU S 2. 94 441020 W79283 Hs. 35962 ESTs 2. 94 425397 J04088 Hs. 156346 topoisomerase (DNA) 11 alpha (170kD) 2. 94 420005 AW271106 Hs. 133294 ESTs 2. 93 412530 AA766268 Hs. 266273 hypothetical protein FW13346 Z93 435602 AF217515 Hs. 283532 uncharacterized bone marrow protein BM03 2. 93 447247 AW369351 Hs. 287955 Homo sapiens cDNA FLJ13090 fis, clone NT 2. 93 443341 AW631480 Hs. 8688 ESTs 2. 92 436481 AA379597 Hs. 5199 HSPC150 protein similar to ubiquitincon 2. 92 410144 W07189 Hs. 68185 ESTs Weakly similar to ARL3_HUMAN ADP-R 2. 92 434450 S78664 Hs. 87 retinoblastoma-like 1 (p107) 2. 92 450402 BE218027 Hs. 89969 ESTs 2. 92 422026 U80736 Hs. 110826 trinucieotide repeat containing 9 2. 92 421562 AA530994 Hs. 334471 ghrelin precursor 2. 92 410434 AF051152 Hs. 63668 toll-like receptor 2 2. 92 422665 AJ011812 Hs. 119018 transcriptionfactorNRF 2. 91 428966 AF059214 Hs. 194687 cholesterol 25-hydroxylase 2. 90 412416 Api628253 Hs. 22580 alkylglycerone phosphate synthase 2. 90 446232 A1281848 Hs. 194691 retinoic acid induced 3 2. 90 454600 AW81000) gb : MR4-ST0124-270300-005-b11 ST0124 Homo 2. 90 438018 AK001160 Hs. 5999 hypothetical protein FLJ10298 2. 90 433252 AB040957 Hs. 151343 KIAA1524 protein 2. 90 444355 BE383686 Hs. 191621 ESTs Moderately similar to ALU6HUMAN A 2. 90 443054 A1745185 Hs. 8939 yes-associated protein 65 kDa 2. 89 421308 AA687322 Hs. 192843 leucine zipper protein FKSG14 2. 89 411643 Ai924519 Hs. 192570 hypotheiicalproteinFW22028 Z89 419559 Y07828 Hs. 91096 dng finger protein 2. 89 433527 AW235613 Hs. 133020 ESTs 2. 88 426274 D38122 Hs. 2007 tumor necrosis factor (ligand) superfami 2. 88 406182 NA NA 2. 88 432731 R31178 Hs. 287820 fibronectin 1 2. 88 429274 A1379772 Hs. 99206 ESTs 2. 87 418216 AA662240 Hs. 283099 AF15q14 protein 2. 87 410166 AK001376 Hs. 59346 hypothetical protein FU10514 2. 86 452665 AW839326 Hs. 330414 ESTs. Moderately similar to S65657 alpha 2. 86 424696 BE439547 Hs. 151903 GrpE-like protein cochaperone 2. 86 410174 AA306007 Hs. 59461 DKFZP434C245 protein 2. 85 443640 A1872643 Hs. 134218 ESTs 2. 85 432912 BE007371 Hs. 200313 ESTs 2. 85 431611 U58766 Hs. 264428 tissue specific transplantation antigen 2. 85 446565 D13757 Hs. 311 phosphoribosyl pyrophosphate amidotransf 2. 85 424770 AA425562 Hs. 11065 Homosapiens HDCME13PmRNA partialcds 2. 84 418845 AA852985 Hs. 89232 chromobox homolog 5 (Drosophila HP1 alph 2. 84 403639 NA NA 2. 84 451110 A1955040 Hs. 265398 ESTs Weaklysimilartotransfommahon-r 2. 84 416185 AW975861 Hs. 47367 KIAA1785 protein 2. 84 444665 BE613126 Hs. 47783 B aggressive lymphoma gene 2. 83 423441 R68649 Hs. 278359 absent in melanoma ! like 2. 83 450584 AA040403 Hs. 60371 ESTs 2. 83 420191 AW003565 Hs. 192323 HomosapiensmRNAforFW00057protein 2. 83 425599 AW366745 Hs. 214140 ESTs Weakly similar to ALU 1-HUMAN ALU S 2. 83 424408 Al754813 Hs. 146428 collagen type V, alpha 1 2. 83 448769 N66037 Hs. 38173 ESTs 2. 82 444946 AW139205 Hs. 156457 hypothetical protein FU22408 2. 82 435347 AW014873 Hs. 116963 ESTs 2. 82 438435 AA807142 Hs. 42194 hypothetical protein FU22649 similar to 2. 82 427687 AW003867 Hs. 1570 histamine receptor H1 2. 82 426951 AA393636 Hs. 97454 ESTs 2. 82 427970 AA418187 Hs. 330515 ESTs 2. 82 442577 AA292998 Hs. 163900 ESTs 2. 82 441016 AW138653 Hs. 25845 ESTs 2. 81 414774 X02419 Hs. 77274 plasminogen activator, urokinase 2. 81 417160 N76497 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 2. 81 409346 AL162066 Hs. 54320 hypothetical protein DKFZp762D096 2. 81 410407 X66839 Hs. 63287 cabonicanhydraselX 2. 81 407137 T97307 gb : ye53hO5. s1 Soares fetal liver spleen 2. 81 435849 BE305242 Hs. 16098 claudin 2 2. 80 426695 AW118191 Hs. 112729 ESTs 2. 80 428301 AW628666 Hs. 98440 ESTs Weakly similar to 138022 hypotheti 2. 80 420759 T11832 Hs. 127797 HomosapienscDNAFU11331fisfcloneHE 2. 80 421341 AJ243212 Hs. 279611 deleted in malignant brain tumors 1 2. 80

419423 D26488 Hs. 90315 KIAA0007 protein 2. 79 452355 N54926 Hs. 29202 G protein-coupled receptor 34 2. 79 425826 U97698 Hs. 159593 mucin 6, gastric 2. 79 457465 AW301344 Hs. 122908 DNA replication factor 2. 79 426472 BE246138 Hs. 30853 ESTs 2. 79 424081 NM 006413 Hs. 139120 ribonucleaseP (30kD) 2. 78 425851 NM001490 Hs. 159642 glucosaminyl (N-acetyl) transferae 1, c 278 419236 M330447 Hs. 135159 Homo sapiens CDNA FU 11481 fis, clone HE 2. 78 423430 AF112481 Hs. 128501 RAD54. S. cerevisiae, homolog of, B 2. 78 410011 AB020641 Hs. 57856 PFTAIRE protein kinase 1 2. 78 453700 AB009426 Hs. 560 apolipoprotein B mRNA editing enzyme, ca 2. 78 431250 BE264649 Hs. 251377 taxol resistance associated gene 3 2. 77 414043 A1521210 Hs. 97977 ESTs 2. 77 418054 NM 002318 Hs. 83354 tysyl oxidase-like 2 2. 77 439223 AW238299 Hs. 250618 UL16 binding protein 2 2. 76 425956 M60828 Hs. 164568 fibroblast growth factor 7 (keratnocyte 2. 76 437612 AA827715 Hs. 105153 Homo sapiens, clone IMAGE : 3461987, mRNA, 2. 76 426119 W94997 Hs. 189917 ESTs 2. 76 459574 A1741122 Hs. 101810 HomosapienscDNAFW14232hs, cloneNT 2. 76 442339 BE299668 Hs. 227591 ESTs, Weakly similar to 1901303A Leu zip 2. 76 414334 AA824298 Hs. 21331 hypothetical protein FU 10036 2. 76 418217 A1910647 Hs. 13442 ESTs 2. 76 420022 AA256253 Hs. 120817 ESTs 2. 76 408243 Y00787 Hs. 624 interleukin 8 2. 75 421346 Z34277 Hs. 103707 apomucin 2. 75 421379 Y15221 Hs. 103982 smal inducibie cytohne subfamily B (Cy 2. 75 425773 N21279 Hs. 237749 ESTs 2. 75 449611 A1970394 Hs. 197075 ESTs 2. 74 424827 A1057094 Hs. 96867 Homo sapiens cDNA : FLJ23155 fis, clone L 2. 74 448621 A1097144 Hs. 5250 ESTs, WeaklysimilartoALU1_HUMANALUS 2. 74 428523 AW974540 Hs. 98626 ESTs 2. 73 410839 NM 006849 Hs. 66581 protein disulfide isomerase 2. 73 437380 AL359577 Hs. 112198 HomosapiensmRNA, cDNADKFZp547M073 ('r 2. 73 424641 AB001106 Hs. 151413 glia maturation factor, beta 2. 73 431708 A1698136 Hs. 108873 ESTs 2. 73 436209 AW850417 Hs. 254020 ESTs, Moderately similar to unnamed prot 2. 73 441790 AW294909 Hs. 132208 ESTs 2. 73 428862 Nom-000346 Hs. 2316 SRY (sex determining region Y)-box 9 (ca 2. 73 409506 NM_006153 Hs. 54589 NCK adaptor protein 1 2. 73 423482 BE280172 Hs. 129228 galactokinase 2 2. 73 417015 M83772 Hs. 80876 flavin containing monooxygenase 3 2. 72 448165 Nom-005591 Hs. 202379 meioUcrecombinafon (S. cerevisiae) 11 2. 72 448826 Ai580252 Hs. 293246 ESTs, Weakly similar to putatvept 50 JH 2. 72 447803 BE620578 Hs. 30858 ESTs. Weakly similar to S65657 alpha-1 G 2. 72 429703 T93154 Hs. 28705 ESTs 2. 72 448796 AA147829 Hs. 301431 endothelial zinc finger protein induced 2. 72 410902 AW809665 gb : MR4-ST0124-261099-015-gO7 ST0124 Homo 2. 72 424745 AA214618 Hs. 152759 activator of S phase kinase 2. 72 454469 AW792775 gb : CMO-UM0001-010300-256-g10UM0001 Homo 2. 72 458632 A1744445 Hs. 167073 Homo sapiens CDNA FU13047 fis, clone NT 2. 72 452012 AA307703 Hs. 279766 kinesin family member 4A 2. 72 422109 S73265 Hs. 1473 gastrin-reteasingpeptide 2. 72 438008 AA775026 Hs. 203802 ESTs 2. 72 420552 AK000492 Hs. 98806 hypothetical protein 2. 71 427038 NM 014633 Hs. 173288 KIAA0155 gene product 2. 71 409239 AA740875 Hs. 44307 ESTs, Moderately similar to 138022 hypot 2. 71 425371 D49441 Hs. 155981 mesothelin 2. 71 439857 AA847194 Hs. 232002 ESTs 2. 71 455309 AW894017 gb : RC4-NN0027-150400-012-g04NN0027Homo 2. 71 439580 AF086401 Hs. 293847 ESTs, Moderately similar to S65657 alpha 2. 70 437257 A1283085 Hs. 290931 ESTs, Weakly similar to YFJ7YEASTHYPOT 2. 70 435039 AW043921 Hs. 130526 ESTs 2. 70 438796 W67821 Hs. 109590 genethonin 1 2. 70 407013 U35637 gb : HumannebulinmRNA, partialcds 2. 70 445413 AA151342 Hs. 12677 CGI-147 protein 2. 70 418416 U11700 Hs. 84999 ATPase, CuHtransporting, beta polypept 2. 70 441362 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re 2. 69 448045 AJ297436 Hs. 20166 prostate stem cell antigen Z69 441868 A1400276 Hs. 183485 ESTs 2. 69 449076 A1627826 Hs. 209109 ESTs 2. 69 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 2. 69 427617 D42063 Hs. 199179 RAN binding protein 2 2. 69 414618 A1204600 Hs. 96978 hypothetical protein MGC10764 2. 69 441350 AB020690 Hs. 7782 paraneoplastic antigen MA2 2. 68 419310 AA236233 Hs. 188716 ESTs 2. 68 445279 R41900 Hs. 22245 ESTs 2. 68 439741 BE379646 Hs. 6904 Homo sapiens MRNA full length insert cDN 2. 68 446692 Z44514 Hs. 156829 Homo sapiens mRNA for KIAAI 763 protein, 2. 68 449300 A1656959 Hs. 222165 ESTs 2. 68 444585 AW170015 Hs. 6594 ESTs 2. 68 444384 BE174527 Hs. 11065 Homo sapiens HDCME13P MRNA, parfial cds 2. 68 448104 A1674818 Hs. 316433 HomosapienscDNAFLJ11375fiscloneHE 2. 67 446839 BE091926 Hs. 16244 mitotic spindle coiled-coil related prot 2. 67

428361 NM 015905 Hs. 183858 transcnptionaiintermediaty factor ! 2. 67 418971 AA360392 Hs. 87113 ESTs 2. 66 446152 A1292036 Hs. 150028 ESTs 2. 66 441553 AA281219 Hs. 121296 ESTs 2. 66 403548 NA 2. 66 452699 AW295390 Hs. 213062 ESTs 2. 66 449532 W74653 Hs. 271593 ESTs, Moderately similar to A47582 B-cel 2. 66 453985 N44545 Hs. 251865 ESTs 2. 65 409956 AW103364 Hs. 727 inhibin, beta A (activin A, activin AB a 2. 65 409446 A1561173 Hs. 67688 ESTs 2. 65 422094 AF129535 Hs. 272027 F-box only protein 5 2. 65 445462 AA378776 Hs. 288649 hypothetical protein MGC3077 2. 64 432670 AA806536 Hs. 291841 ESTs 2. 64 418634 AK000064 Hs. 86905 ATPase. H+ transporting, lysosomal (vacu 2. 64 453628 AW243307 Hs. 83937 hypothetical protein Z64 442117 AW664964 Hs. 128899 ESTs 2. 64 416248 H99169 Hs. 23450 mitochonddal dbosomal protein S25 2. 64 414631 AW970130 Hs. 65406 ESTs 2. 64 423268 BE386898 Hs. 131162 ESTs, WeakhysimilartoAW5_HUMANALUS 2. 64 413597 AW302885 Hs. 117183 ESTs 2. 63 446031 AI271704 Hs. 18987 HomosapiensBACcloneRPll-505D17hrom Z63 450142 AW207469 Hs. 24485 chondroinnsutfateproteoglycan6 (bama 2. 63 436304 AA339622 Hs. 108887 ESTs 2. 63 439832 T81829 Hs. 14870 Homo sapiens, Similar to hect domain and 2. 63 449207 AL044222 Hs. 23255 nucleoporin 155kD 2. 62 416111 AA033813 Hs. 79018 chnomaUnassemblyfætor1, subunitA (2. 62 414747 U30872 Hs. 77204 centromere protein F (350/400kD, mitosin Z62 423811 AW299598 Hs. 50895 homeo box C4 2. 62 439474 A1824060 Hs. 211501 ESTs 2. 62 417218 AA005247 Hs. 285754 met proto-oncogene (hepatocyte growth fa 2. 62 408031 AA081395 Hs. 42173 Homo sapiens cDNA FLJ10366 fis, clone NT 2. 62 442821 BE391929 Hs. 8752 transmembrane protein 4 2. 62 418245 AA088767 Hs. 83883 transmembrane, prostate androgen induced 2. 62 447917 AL048037 Hs. 164588 ESTs, Moderately similar to neuronal thr 2. 61 424840 D79987 Hs. 153479 extra spindle poles, S. cerevisiae, homo 2. 61 443268 A) 800271 Hs. 129445 hypothetical protein FU12496 2. 61 403056 R58624 Hs. 2186 eukaryotic translation eiongation factor 2. 61 433037 NM_014158 Hs. 279938 HSPC067 protein 2. 61 410358 AW975168 Hs. 13337 ESTs, Weakly similar to unnamed protein 2. 60 426181 AA371422 Hs. 334371 hypothetical protein MGC13096 2. 60 414853 U31116 Hs. 77501 sarcoglycan, beta (43kD dystrophin-assoc 2. 60 457233 A1355009 Hs. 221698 ESTs 2. 60 416049 A1970536 Hs. 16603 hypothetical protein FLJ13163 2. 60 418946 A1798841 Hs. 164526 ESTs 2. 60 441891 AW129145 Hs. 128076 ESTs 2. 60 443742 AW627805 Hs. 145421 ESTs 2. 60 433868 AA612960 Hs. 337300 ESTs 2. 60 442717 R88362 Hs. 180591 ESTs, Weakly similar to T23976 hypotheU 2. 59 444542 A1161293 Hs. 280380 aminopeptidase 2. 59 452940 AA029722 Hs. 2173 hucosyltTansferase4 (apha (1, 3pfucosy 2. 59 429170 NM001394 Hs. 2359 dual specificity phosphatase 4 2. 59 417531 NM 003157 Hs. 1087 serine/threonine kinase 2 2. 59 401458 NA 2. 58 436016 AA806465 Hs. 121536 Human DNA sequence from clone RPI 1-472E5 2. 58 430980 AW971904 Hs. 122164 diaphanous (Drosophila, homolog) 3 2. 58 441581 BE551408 Hs. 127196 ESTs 2. 58 435693 A1033134 Hs. 119887 ESTs 2. 58 431814 BE256242 Hs. 270847 delta-tubulin 2. 58 446269 AW263155 Hs. 14559 hypothetical protein FLJ 10540 2. 58 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur 2. 58 456999 AA319798 Hs. 298581 eukaryotictranstationetongation factor 2. 58 425234 AW152225 Hs. 165909 ESTs. Weakly similar to 138022 hypotheti 2. 58 434423 NM006769 Hs. 3844 LIM domain only 4 2. 57 425782 U66468 Hs. 159525 cell growth regulatory with EF-hand doma 2. 57 433929 A1375499 Hs. 27379 ESTs 2. 57 414907 X90725 Hs. 77597 polo (Drosophia)-like kinase 2. 57 411789 AF245505 Hs. 72157 DKFZP56411922 protein 2. 57 435627 W88774 Hs. 118370 ESTs 2. 57 432168 AK000563 Hs. 272805 hypothetical protein FLJ20556 2. 57 432375 BE536069 Hs. 2962 S100 calcium-binding protein P 2. 57 424057 A1339874 Hs. 126593 ESTs 2. 57 424315 AW614850 Hs. 193384 putatative 28 kDa protein 2. 57 435663 A1023707 Hs. 134273 ESTs 2. 56 439277 R80061 Hs. 164478 hypothetical protein FU21939 similar to 2. 56 427747 AW411425 Hs. 180655 sehneahreonine kinase 12 2. 56 438182 AW342140 Hs. 182545 ESTs, Weakly similar to ALU 1 _HUMAN ALU S 2. 56 421102 Api470093 Hs. 283085 protocadherin beta 6 2. 56 445725 AK000956 Hs. 13209 hypothetical protein FLJ10094 2. 56 448243 AW369771 Hs. 52620 integrin, beta 8 2. 56 442881 A1023175 Hs. 167022 ESTs 2. 56 422165 AL041199 Hs. 1481 histidine decarboxylase 2. 56 425843 BE313280 Hs. 159627 death associated protein 3 2. 56 448569 BE382657 Hs. 21486 signal transducer and activator of trans 2. 55

416806 NM000288 Hs. 79993 peroxisomal biogenesis factor 7 2. 55 438113 A1467908 Hs. 8882 ESTs 2. 55 413374 NM 001034 Hs. 75319 ribonucleotide reductase M2 polypeptide 2. 55 448275 BE514434 Hs. 20830 kinesin-like 2 2. 55 419987 NM 005014 Hs. 94070 osteomodulin 2. 55 439929 S73205 gb : insulin activator fætor human, panc 2. 55 452240 A1591147 Hs. 61232 ESTs 2. 55 417806 A1867277 Hs. 183733 ESTs 2. 55 421482 AL135462 Hs. 104715 inversin 2. 55 456884 AA054679 Hs. 155150 nbonucleaeP (14kD) 2. 55 442961 BE614474 Hs. 289074 F-box only protein 22 2. 55 411274 NM 002776 Hs. 69423 kallikrein 10 2. 55 419359 AL043202 Hs. 90073 chromosome segregation 1 (yeast homdog) 2. 54 448666 NM014953 Hs. 323346 KIAA1008 protein 2. 54 428911 Z43846 Hs. 194478 HomosapiensmRNA ; cDNADKFZp43401572 ( 2. 54 452778 R71338 Hs. 5921 Homo sapiens cDNA : FU21592 fis, clone C 2. 54 430733 AW975920 Hs. 283361 ESTs 2. 54 421184 NM 003616 Hs. 102456 survival of motor neuron protein interac 2. 54 435361 Al168596 Hs. 117117 ESTs 2. 54 452833 BE559681 Hs. 30736 KIAA0124 protein 2. 54 422330 D30783 Hs. 115263 epiregulin 254 424962 NM 012288 Hs. 153954 TRAM-like protein 2. 54 430264 AA470519 gb : nc71fl O. sl NCl_CGAP_Prl Homo sapiens 2. 53 447178 AW594641 Hs. 192417 ESTs 2. 53 411773 NM 006799 Hs. 72026 protease, serine, 21 (testisin) 2. 53 433571 AA765256 Hs. 135191 ESTs, Weakly similar to unnamed protein 2. 53 419449 H18417 Hs. 57483 Homo sapiens cDNA FLJ14294 fis, clone PL 2. 53 448019 AW947164 Hs. 195641 ESTs, Moderately similar to 138022 hypot 2. 53 409435 Al810721 Hs. 95424 ESTs 2. 52 417900 BE250127 Hs. 82906 CDC20 (cell division cycle 20, S. cerevi 2. 52 431385 BE178536 Hs. 11090 membrane-spanning 4-domains, subfamily A 2. 52 422314 K01900 Hs. 73890 interferon, alpha 8 2. 52 441343 A1970348 Hs. 132230 ESTs 2. 52 417185 NM_002484 Hs. 81469 nucleotide binding protein 1 (E. coli Min 2. 52 401747 NA 2. 52 448526 AB028946 Hs. 21361 KIAA1023 protein 2. 52 419488 AA316241 Hs. 90691 nucleophosmin/nucleoplamin 3 2. 52 413627 BE182082 Hs. 246973 ESTs 2. 51 441285 NM002374 Hs. 167 microtubule-associated protein 2 2. 51 446921 AB012113 Hs. 16530 small inducible cytokine subfamily A (Cy 2. 51 429357 AA779725 Hs. 164589 ESTs 2. 51 443171 BE281128 Hs. 9030 TONDU 2. 50 446636 AC002563 Hs. 15767 citron (rho-intera6ng, senne/threonin 2. 50 420795 AA323037 Hs. 128645 sorting nexin 16 2. 50 448582 A1538880 Hs. 94812 ESTs 2. 50 445459 Api478629 Hs. 158465 likely ortholog of mouse putative IKK re 2. 50 423909 AJ223183 Hs. 135194 immunoglobulin superfamily, member 6 2. 50 414315 Z24878 gb : HSB65D052 STRATAGENE Human skeletal in 2. 50 407568 AA740964 Hs. 62699 ESTs 2. 50 453911 AW503857 Hs. 4007 Sarcolemmal-associated protein 2. 50 431571 AW500486 Hs. 180610 splicing factor prolinelglutamine rich (2. 50 433843 AW021423 Hs. 112819 ESTs 2. 50 456254 T19844 gb : B711FHeartHomosapienscDNAcloneB 2. 50 403137 NA 2. 50 425895 Al269484 Hs. 161427 zinc finger protein 215 2. 50 418612 AB037788 Hs. 224961 cleavage and polyadenylation specific fa 2. 50 TABLE 45B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accessions 410784 1221005_1 AW803201 BE079700BE062940 410902 1226078 1 AW809665 AW810108 AW809781 AW809844 411765 1257001 H43346AA248302AA095182 413170 1351880_1 BE068819 BE068821 BE068825 413516 1374595 1 BE145907 BE145796 BE145803 BE145851 BE145923 BE145812 BE145809 BE145852 BE145856 414315 143512J Z24878AA494098F13654AA494040AA143127 428858 296453_1 M436760 AW237453 BE327496 N47347 N56967 430264 315008 1 AA470519 BE303010 BE302954 BE384120 431322 331543_1 AW970622 AA503009 AA502998 AA502989 AA502805 T92188 434138 380572 1 M625804 AW418787 AW074833 A1675642 Api393368 436411 419334 1 AW674352M715374Z25205 438159 45106-2 Z83947 439929 48059-1 S73205 451105 859083_1 A1761324 AW880941 AW880937 452453 918300 1 AI902519 AI902518 AI902516 454469 12137271 AW792775 BE072509 AW792958 454600 1226077 1 AW810001 AW810092 AW810170 AW809884 AW809664 AW810353 AW810428AW810209 AW810429AW810154 AW810168 AW809786 AW810006 AW809672 AW809694 AW810552 AW810345 AW810432 AW809960 454821 1236365 1 AW833504AW833751 AW633493AW833341 455309 12781531 AW894017AW893956AW894032

456254 1699246-1 T19844 Tl 1755 T11830 T20136 T11957 R45834 R45828 R15595 TABLE 45C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers."Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nu-position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 401458 9187886 Plus 76485-77597 401644 8576138 Plus 82655-83959 401747 9789672 Minus 118596-118816, 119119-119244, 119609-119761, 120422-120990, 130161-130381, 130468-130593, 131097-131258, 131866- 131932, 132451-132575. 133580-134011 402167 8571795 Plus 109122-110357 402299 6693370 Plus 23367-25175 402408 9796239 Minus 110326-110491 403137 9211494 Minus 92349-92572. 92958-93084, 93579-9371t93949-9407Z94591-94748, 9s21495337 403381 9438267 Minus 26009-26178 403422 9665041 Minus 151169-151561 403548 8081591 Minus 38760-39352 403637 8671936 Minus 142647-142771, 145531-145762 403639 8671948 Plus 113234-113326. 11518&115287, 11964119786 403776 7770611 Minus 1414-1513. 1624-1756 404253 9367202 Minus 55675-56055 404440 7528051 Plus 80430-81581 404766 7882612 Minus 158681-158882, 160838-160973 404996 6007890 Plus 3799938145, 38652-38998, 39727-39872, 40557-40674, 42351-42450 405466 7767904 Minus 64498-64675 405770 2735037 Plus 61057-62075 405817 4071056 Plus 19914-20112, 25655-25810 406117 9142932 Plus 54304-54584 406182 5923650 Minus 28256-28935 TABLE 46A : ABOUT 1303 GENES UP-REGULATED IN STOMACH CANCER COMPARED TO NORMAL STOMACH Table 46A lists about 1303genes up-regulated in stomach cancer compared to normal stomach. These were selected as for Table 45A except using non-malignant stomach specimens in determining the denominator value and the ratio was equal to or greater than 5. 0. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of tumor to normal body tissue Pkey ExAccn UnigenelD Unigene Title R1 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponún, 80. 50 414152 NM 003248 Hs. 75774 thrombospondin 4 70. 52 421552 AF026692 Hs. 105700 secreted frizzled-related protein 4 65. 30 428698 AA852773 Hs. 334838 KIAA1866 protein 61. 90 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin 50. 60 409041 AB033025 Hs. 50081 KIAA119 protein 44. 50 452281 T93500 Hs. 28792 Homo sapiens CDNA FU 11041 fis, clone PL 41. 10 452862 AW378065 Hs. 8687 ESTs 33. 50 427585 D31152 Hs. 179729 collagen, type X, alpha 1 (Schmid metaph 32. 10 424834 AK001432 Hs. 153408 Homo sapiens cDNA FLJ10570 fis, clone NT 26. 90 428398 A1249368 Hs. 98558 ESTs 26. 40 409757 NM 001898 Hs. 123114 cystatinSN 25. 48 403776 NA 24. 90 427674 NM_003528 Hs. 2178 H2Bhistonefamily, memberQ 23. 80 419968 X04430 Hs. 93913 intedeukin 6 (interferon, beta 2) 23. 10 427108 AB028976 Hs. 173571 KIAA1053 protein 21. 76 452401 NM 007115 Hs. 29352 tumor necrosis factor, alpha-induced pro 20. 70 400419 AF084545 NA 20. 40 415989 A1267700 Hs. 317584 ESTs 19. 80 432101 Al918950 Hs. 123642 EphA3 19. 70 418994 AA296520 Hs. 89546 selectin E (endothelial adhesion molecul 19. 00 452110 T47667 Hs. 28005 Homo sapiens cDNA FLJ11309 fis, clone PL 18. 40 412652 A1801777 Hs. 6774 ESTs 18. 20 414430 A1346201 Hs. 76118 ubiqudincarboxyl-terminalesteraeL1 17. 71 422168 AA586894 Hs. 112408 S100calcium-bindingproteinA7 (psoas 17. 38 448988 Y09763 Hs. 22785 gamma-aminobutyric acid (GABA) A recepto 17. 36 437446 AA788946 Hs. 16869 ESTs, Moderately similar to CA1 C RAT COL 17. 00 440594 AW445167 Hs. 126036 ESTs 17. 00 430044 AA464510 Hs. 152812 ESTs 17. 00 426647 AA243464 Hs. 294101 pre-B-cell leukemia transcription factor 16. 90 414737 Al 160386 Hs. 125087 ESTs 16. 50 427335 AA448542 Hs. 251677 G antigen 78 16. 30 423453 AW450737 Hs. 128791 CGI-09 protein 15. 50 414569 AF109298 Hs. 118258 prostate cancer associated protein 1 15. 40 401961 NA NA 15. 40 434551 BE387162 Hs. 280858 ESTs. Highly similar to A35661 DNA excis 15. 40 432069 AW975868 Hs. 294100 ESTs 15. 30 434699 AA643687 Hs. 149425 Homo sapiens cDNA FLJ11980 fis, clone HE 15. 30

409062 AL157488 Hs. 50150 HomosapiensmRNA ; cDNADKFZp564B182 (fr 15. 30 400289 X07820 Hs. 2258 matrix metaitoproteinase 10 (stromelysin 15. 20 415138 C18356 Hs. 295944 tissue factor pathway inhibitor 2 15. 20 428820 AA436187 Hs. 172631 integdn, alpha M (complement component 15. 19 410763 AF279145 Hs. 8966 hypothetical protein FU21776 15. 10 438639 A1278360 Hs. 31409 ESTs 15. 10 458997 AW937420 Hs. 69662 ESTs 15. 00 432731 R31178 Hs. 287820 fibronectin 1 14. 90 459247 N46243 Hs. 110373 ESTs Highly similar to T42626 secreted 14. 70 451099 R52795 Hs. 25954 intedeukin 13 receptor, alpha 2 14. 70 452242 R50956 Hs. 159993 gycosyltransferase 14. 70 426427 M86699 Hs. 169840 TTK protein kinase 14. 50 439924 Ai985897 Hs. 125293 ESTs 14. 45 414869 AA157291 Hs. 21479 ubinuclein 1 14. 40 411573 AB029000 Hs. 70823 KIAA1077 protein 14. 40 418693 A1750878 Hs. 87409 thrombospondin 1 14. 37 421823 N40850 Hs. 28625 ESTs 14. 30 423903 M57765 Hs. 1721 intedeuin 11 14. 20 419227 BE537383 Hs. 89739 cholinergic receptor, nicotinic, beta po 14. 10 447417 AW732858 Hs. 143067 KIAA1602 protein 13. 96 416406 D86961 Hs. 79299 lipoma HMGIC fusion partner-like 2 13. 90 446392 AF142419 Hs. 15020 homolog of mouse quaking QKl (KH domain 13. 90 412863 AA121673 Hs. 59757 zinc finger protein 281 13. 90 449509 AA001615 Hs. 84561 ESTs 13. 80 440953 Api683036 Hs. 124135 HomosapienscDNAFW13051fis cloneNT 13. 80 432415 T16971 Hs. 289014 ESTs Weakly similar to A43932 mucin 2 p 13. 60 428769 AW207175 Hs. 106771 ESTs 13. 60 416292 AA179233 Hs. 42390 nasopharyngeal carcinoma susceptibility 13. 41 424580 AA446539 Hs. 339024 ESTs Weakly similar to A46010 X-linked 13. 40 438459 T49300 Hs. 35304 Homo sapiens cDNA FW13655 fis clone PL 13. 30 431958 X63629 Hs. 2877 cadhedn 3, type 1, P-cadhedn (placenta 13. 26 406972 M32053 gb : Human H1 RNA gene, complete cds. 13. 19 432368 AW970244 Hs. 162188 ESTs 13. 16 424806 AA382523 Hs. 105689 MSTP031 protein 13. 08 440351 AF030933 Hs. 7179 RAD1 (S. pombe) homolog 12. 98 437789 Api581344 Hs. 127812 ESTs Weakly similar to T17330 hypotheti 12. 90 447164 AF026941 Hs. 17518 Homosapienscig5mRNA partialsequence 12. 80 417412 X16896 Hs. 82112 inteneukintreceptor. typei 12. 80 402363 NA NA 12. 78 444301 AK000136 Hs. 10760 asporin (LRRclas 1) 12. 76 416783 AA206186 Hs. 79889 monocyte to macrophage differentiation-a 12. 60 435706 W31254 Hs. 7045 GL004 protein 12. 50 414618 A1204600 Hs. 96978 hypotheticalprotein MGC10764 12. 50 439737 Api751438 Hs. 41271 HomosapiensmRNAhulllengthinsertcDN 12. 49 405770 NA 12. 46 418678 NM001327 Hs. 167379 cancer/testis antigen 12. 45 414132 A1801235 Hs. 48480 ESTs 12. 40 410434 AF051152 Hs. 63668 toil-like receptor 2 12. 30 451092 AI207256 Hs. 13766 HomosapiensmRNAforFW00074protein 12. 26 407891 AA486620 Hs. 41135 endomucin-2 12. 20 450506 NM004460 Hs. 418 fibroblast activation protein, alpha 12. 01 411213 AA676939 Hs. 69285 neuropilin 1 12. 00 436476 AA326108 Hs. 33829 bHLH protein DEC2 12. 00 413582 AW295647 Hs. 71331 hypothetical protein MGC5350 11. 90 449318 AW236021 Hs. 78531 Homosapiens SimilartoRIKENcDNA5730 11. 90 401747 NA 11. 88 409619 AK001015 Hs. 55220 BCL2-associated athanogene 2 11. 84 432596 AJ224741 Hs. 278461 math) 3 11. 80 400298 AA032279 Hs. 61635 six transmembrane epithelial antigen of 11. 73 425688 U48361 Hs. 159223 NGFI-A binding protein 2 (ERG1 binding p 11. 72 407938 AA905097 Hs. 85050 phospholamban 11. 70 419948 AB041035 Hs. 93847 NADPH oxidase 4 11. 70 459645 AA074346 Hs. 250715 ESTs 11. 51 438462 A1624122 Hs. 89578 general transcription factor IIH, polype 11. 50 434851 AA806164 Hs. 116502 ESTs 11. 50 418699 BE539639 Hs. 173030 ESTs WeaklysimilarbAW8_HUMANALUS 11. 47 413453 AA129640 Hs. 128065 ESTs 11. 40 442028 A1239437 Hs. 48945 ESTs 11. 40 428479 Y00272 Hs. 184572 cell division cycle 2, G1 to S and G2 to 11. 39 453313 BE005771 Hs. 153746 hypothetical protein FU22490 11. 20 421633 AF121860 Hs. 106260 sorting nexin 10 11. 20 410339 A1916499 Hs. 298258 ESTs 11. 20 448111 AA053486 Hs. 20315 intederon-inducedproteinwithtetratri 11. 15 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 11. 15 430217 N47863 Hs. 336901 ribosome protein S24 11. 10 452823 AB012124 Hs. 30696 transcription factor-like 5 (basic helix 11. 10 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) 11. 06 416854 H40164 Hs. 80296 Purkinie cell protein 4 10. 90 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 10. 90 424882 A1379461 Hs. 153636 far upstream element (FUSE) binding prot 10. 80 448693 AW004854 Hs. 228320 hypothetical protein FLJ23537 10. 80 408750 BE294069 Hs. 93581 hypothetical protein FU10512 10. 80 450221 AA328102 Hs. 24641 cytoskeleton associated protein 2 10. 80

436411 AW674352 gb : ba63c07. y1 NIH_MGC_12 Homosapiens cD 10. 80 441693 AA384673 Hs. 7943 RPB5-mediating protein 10. 80 414922 D00723 Hs. 77631 glycine cleavage system protein H (amino 10. 80 441801 AW242799 Hs. 86366 ESTs 10. 80 417173 U61397 Hs. 81424 ubiquitin-iiketjsentrin) 10. 80 415727 BE501389 Hs. 20848 ESTs. Weakly similar to APAF HUMAN APOPT 10. 80 414142 AW368397 Hs. 150042 Homo sapiens cDNA FW 14438 fis, clone HE 10. 80 421650 AA781795 Hs. 122587 ESTs 10. 80 439999 AA115811 Hs. 6838 ras homolog gene family, member E 10. 70 421814 L12350 Hs. 108623 thrombospondin 2 10. 69 415060 AJ223810 Hs. 43213 ESTs, Weakly similar to IEFS_HUMAN TRANS 10. 67 421462 AF016495 Hs. 104624 aquaporin 9 10. 66 410444 W73484 gb : zd54e04. sl Soaresjetal heart NbHH19W 10. 61 409743 N48721 Hs. 183506 hypothetical protein FLJ14213 10. 60 446142 A1754693 Hs. 145968 ESTs 10. 60 444114 T58003 Hs. 10323 HomosapiensmRNAfromchromosome5q31-3 10. 60 423020 AA383092 Hs. 1608 replication protein A3 (14kD) 10. 55 453891 AB037751 Hs. 36353 Homo sapiens mRNA full length insert cDN 10. 50 417352 AA195919 gb : zp95hO9. rl Stratagene muscle 937209 H 10. 46 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 10. 42 427718 A1798680 Hs. 25933 ESTs 10. 40 412589 R28660 Hs. 24305 ESTs 10. 40 433332 A1367347 Hs. 44898 Homo sapiens clone TCCCTA00151 mRNA sequ 10. 40 424717 H03754 Hs. 152213 wingless-bpeMMTVintegraionsitefami 10. 30 450434 AA166950 Hs. 195870 hypotheticalprotein FU14991 10. 30 409044 Api129586 Hs. 33033 hypothe ical prolein FLJ14623 10. 30 423600 Al633559 Hs. 310359 ESTs 10. 30 433819 AW511097 Hs. 112765 ESTs 10. 18 415076 NM000857 Hs. 77890 guanylate cyclase 1, soluble, beta 3 10. 10 410503 AW975746 Hs. 188662 KIAA1702 protein 10. 10 433800 A1034361 Hs. 135150 tungtype-iceii membrane-associated gty 10. 10 429357 AA779725 Hs. 164589 ESTs 10. 00 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 10. 00 414117 W88559 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 10. 00 416198 H27332 Hs. 99598 hypothetical protein MGC5338 10. 00 413918 AW015898 Hs. 71245 ESTs 10. 00 400570 NA NA 10. 00 439333 AW384710 Hs. 125258 Homo sapiens cDNA FLJ13795 fis, clone TH 9. 97 444863 AW384082 Hs. 104879 serine (or cysteine) proteinase inhibito 9. 93 450101 AV649989 Hs. 24385 Human hbc647 mRNA sequence 9. 90 434352 AF129505 Hs. 86492 small muscle protein, X-linked 9. 90 453160 AI263307 Hs. 239884 H2B histone family, member L 9. 90 433929 A1375499 Hs. 27379 ESTs 9. 89 413273 U75679 Hs. 75257 stem-loop (histone) binding protein 9. 81 437536 X91221 Hs. 144465 ESTs 9. 80 441350 AB020690 Hs. 7782 paraneoplastic antigen MA2 9. 80 452291 AF015592 Hs. 28853 CDC7 (cell division cycle 7, S. cerevisi 9. 80 438913 A1380429 Hs. 172445 ESTs 9. 80 417849 AW291587 Hs. 82733 nidogen 2 9. 78 424086 A1351010 Hs. 102267 lysyl oxidase 9. 72 428186 AW504300 Hs. 295605 mannosidase, alpha, class 2A, member 2 9. 70 414422 AA147224 Hs. 337232 ESTs 9. 70 419197 N48921 Hs. 27441 KIAA1615 protein 9. 70 427660 A1741320 Hs. 114121 Homo sapiens cDNA : FLJ23228 fis, clone C 9. 70 449347 AV649748 Hs. 295901 KIAA0493 protein 9. 70 409643 AW450866 Hs. 257359 ESTs 9. 70 436209 AW850417 Hs. 254020 ESTs, Moderately similar to unnamed prot 9. 70 439608 AW864696 Hs. 301732 hypothetica) protein MGC5306 9. 60 430290 A1734110 Hs. 136355 ESTs 9. 60 447124 AW976438 Hs. 17428 RBP1-like protein 9. 60 413879 AA132961 Hs. 212533 HomosapienscDNA : FLJ22572 fis, clone H 9. 60 408101 AW968504 Hs. 123073 CDC2-related protein kinase 7 9. 58 418067 Al127958 Hs. 83393 cystatn E/M 9. 54 424001 W67883 Hs. 137476 paternally expressed 10 9. 50 443037 AW500305 Hs. 299166 syntaxin 7 9. 50 428493 AK001745 Hs. 184628 hypothetical protein FU10883 9. 50 420170 U43374 Hs. 95631 Human normal keratinocyte mRNA 9. 50 409269 AA576953 Hs. 22972 hypothetical protein FLJ13352 9. 50 443162 T49951 Hs. 9029 DKFZP434G032 protein 9. 45 444381 BE387335 Hs. 283713 ESTs, Weakly similar to S64054 hypotheti 9. 43 424026 A1798295 Hs. 137576 ribosomal protein L34 pseudogene 1 9. 40 440052 At633744 Hs. 195648 ESTs, Weakly similar to 138022 hypotheti 9. 40 403137 NA 9. 37 418051 AW192535 Hs. 19479 ESTs 9. 35 418701 AA814948 Hs. 96343 ESTs, Weakly similar to ALUC_HUMAN ! ! ! ! 9. 30 430291 AV660345 Hs. 238126 CGI-49 protein 9. 30 426137 AL040683 Hs. 167031 DKFZP566D133 protein 9. 30 400195 NA NA 9. 30 411529 AA430348 Hs. 317596 Homo sapiens cDNA FLJ12927 fis, clone NT 9. 20 423936 U77629 Hs. 135639 achaete-scute complex (Drosophila) homol 9. 20 414259 W44633 Hs. 301296 HomosapienscDNA : FLJ23131 fis, clone L 9. 20 416661 AA634543 Hs. 79440 IGF-II mRNA-binding protein 3 9. 20 405543 NA NA 9. 20

420900 AL045633 Hs. 44269 ESTs 9. 11 450757 BE081050 Hs. 31570 ESTs. Weakly similar to KIAA1324 protein 9. 10 410929 H47233 Hs. 30643 ESTs 9. 10 427319 AW631495 Hs. 27135 B-cell receptor-associated protein BAP29 9. 10 443745 AB039670 Hs. 9728 ALEX1 protein 9. 10 436574 AW293527 Hs. 126465 ESTs 9. 10 407192 AA609200 gb : af12e02. s1SoarestestisNHTHomosap 9. 08 426075 AW513691 Hs. 270149 ESTs, Weakly similar to 2109260A B cell 9. 07 408778 A1500519 Hs. 63382 hypothetical protein PR02714 9. 03 434542 AA769310 Hs. 61260 hypothetical protein FU13164 9. 00 404440 NA 9. 00 407168 R45175 Hs. 117183 ESTs 9. 00 451678 AA374181 Hs. 26799 DKFZP564D0764 protein 9. 00 431946 A1018336 Hs. 131730 ESTs 8. 92 408875 NM015434 Hs. 48604 DKFZP434B168 protein 8. 90 409928 AL137163 Hs. 57549 hypothetical protein dJ473B4 8. 90 430294 A1538226 Hs. 32976 guanine nucleotide binding protein 4 8. 89 445029 AF196481 Hs. 12256 midline 2 8. 86 442717 R88362 Hs. 180591 ESTs, Weakly similar to T23976 hypotheti 8. 80 409089 NM 014781 Hs. 50421 KIAA0203 gene product 8. 80 419261 X07876 Hs. 89791 wingless-type MMTV integration site fami 8. 80 416190 N54000 gb : yy99d02. rl Soaresmu) tiptesderosis 8. 80 444783 AK001468 Hs. 62180 aniliin (Drosophila Scraps homolog), act 8. 77 416440 A1823912 Hs. 79335 Homo sapiens, Similar to SWI/SNF related 8. 76 421262 AA286746 Hs. 9343 Homo sapiens CONA FU14265 fis, clone PL 8. 70 441031 Al110684 Hs. 7645 fibrinogen, B beta polypeptide 8. 70 452234 AW084176 Hs. 223296 ESTs. Weakly similar to 138022 hypothefi 8. 70 452822 X85689 Hs. 288617 hypothetical protein FU22621 8. 70 430462 Al584156 Hs. 105640 Homo sapiens, clone IMAGE : 4139775, mRNA, 8. 65 426457 AW894667 Hs. 169965 chimerin (chimaerin) 1 8. 65 412054 W87482 Hs. 302209 ESTs 8. 64 450236 AW162998 Hs. 24684 KIAA1376 protein 8. 63 418782 A1792648 Hs. 14665 ESTs 8. 60 452631 A1188658 Hs. 87496 ESTs 8. 60 425268 A1807883 Hs. 180059 Homo sapiens DNA FLJ20653 fis, clone KA 8. 60 432014 H66741 Hs. 38540 ESTs, Weakly similar to ALU4 HUMAN ALU S 8. 60 440270 NM_015986 Hs. 7120 cytokine receptor-like molecule 9 8. 60 414784 NM 000344 Hs. 288986 survivalofmotorneuronl, telomeric 8. 60 426809 BE313114 Hs. 29706 ESTs 8. 60 419704 AA429104 Hs. 45057 ESTs 8. 60 452909 NM 015368 Hs. 30985 pannexin 1 8. 60 432639 AW973785 gb : EST385886 MAGE resequences, MAGM Homo 8. 60 430418 R98852 Hs. 36029 heart and neural crest derivatives expre 8. 58 450480 X82125 Hs. 25040 zincfingerprotein239 8. 58 444984 H15474 Hs. 132898 fatty acid desaturase 1 8. 58 419086 NM000216 Hs. 89591 Kallmann syndrome 1 sequence 8. 57 430518 AW363687 Hs. 82916 chaperonincontainingTCP1, subunit6A (8. 50 424735 U31875 Hs. 272499 short-chain alcohol dehydrogenase family 8. 50 414061 NM000699 Hs. 300280 amylase, alpha 2A ; pancreatic 8. 50 407894 AJ278313 Hs. 41143 phosphoinositide-specificphospholipase 8. 50 441079 AW150697 Hs. 107418 ESTs 8. 50 419354 M62839 Hs. 1252 apolipoprotein H (beta-2-glycoprotein 1) 8. 50 418618 U66097 Hs. 86724 GTP cyclohydrolase 1 (dopa-responsive dy 8. 50 416565 AW000960 Hs. 44970 endoplasmic reticulum resident protein 5 8. 50 441540 C01367 Hs. 127128 ESTs 8. 50 416434 AW163045 Hs. 79334 nuclear factor, intedeukin 3 regulated 8. 50 417801 AA417383 Hs. 82582 integrin, betalike 1 (with EGF-like rep 8. 50 426855 AL117427 Hs. 172778 Homo sapiens mRNA ; cDNA DKFZp566P013 (fr 8. 48 436515 AJ278111 Hs. 195292 putative tumor antigen 8. 43 416315 AA179483 Hs. 73605 ESTs 8. 42 408432 AW195262 gb : xn67b05. x1 NCI_CGAP_CML1 Homo sapiens 8. 40 410094 BE147897 Hs. 58593 general transcription factor IIF, polype 8. 40 419198 AA234938 Hs. 87384 ESTs 8. 36 448920 AW408009 Hs. 22580 alkylglycerone phosphate synthase 8. 36 410305 AF030409 Hs. 62185 solute carrier family 9 (sodium/hydrogen 8. 31 408687 AL110280 Hs. 301152 Homo sapiens mRNA ; cDNA DKFZp434F053 (hr 8. 30 427707 NM_005578 Hs. 180398 LIM domain-containing preferred transloc 8. 30 459060 H89244 Hs. 303627 heterogeneous nuclear ribonucleoprotein 8. 30 451957 A1796320 Hs. 10299 Homo sapiens CONA FU13545 fis, clone PL 8. 30 443977 AL120986 Hs. 150627 ESTs, Weakly similar to 138022 hypotheb 8. 30 457997 AA806616 Hs. 209523 ESTs 8. 30 451934 A1540842 Hs. 61082 ESTs 8. 30 404335 NA 8. 30 445073 AW291389 Hs. 13056 hypothetical protein FLJ 13920 8. 30 431566 AF176012 Hs. 260720 J domain containing protein 1 8. 29 446307 T50083 Hs. 9094 ESTs 8. 28 423928 AA332680 gb : EST36768 Embryo, 8 week I Homo sapien 8. 26 436420 AA443966 Hs. 31595 ESTs 8. 25 426110 NM002913 Hs. 166563 replication factor C (activator 1) 1 (14 8. 25 442988 A1026130 Hs. 131683 ESTs 8. 25 402408 NA NA 8. 24 438707 L08239 Hs. 5326 amino acid system N transporter 2 ; porcu 8. 23 425770 NM014363 Hs. 159492 spaticataxiao'Chadevoix-sæuenay (s 8. 22

448704 AW080932 Hs. 249247 heterogeneous nuclear protein similar to 8. 21 452682 AA456193 Hs. 9071 progesterone membrane binding protein 8. 20 411984 NM 005419 Hs. 72988 signattransducerandactivatoroftrans 8. 20 420018 U56387 Hs. 94376 proproReinconvertzesubtilisin/kexint 8. 20 437048 AA743240 Hs. 91582 ESTs 8. 20 424653 AW977534 Hs. 151469 calcium/calmodulin-dependent serine prot 8. 20 447066 BE167667 Hs. 32163 ESTs 8. 20 425932 M81650 Hs. 1968 semenogelin 1 8. 20 431819 AA515995 Hs. 152334 ESTs 8. 20 431810 X67155 Hs. 270845 kinesin-like 5 (mitotic kinesin-like pro 8. 20 459702 A) 204995 9b : anO3cO3. xl Stratagene schizo brain Si 8. 20 406687 M31126 Hs. 272620 pregnancyspecificbet1-glycoprotein9 8. 18 413109 AW389845 Hs. 110855 ESTs 8. 17 424720 M89907 Hs. 152292 SWIISNF related, matrix associated, act 8. 16 424335 AW021508 Hs. 28170 ESTs 8. 10 453096 AW294631 Hs. 11325 ESTs 8. 10 427738 NM0318 Hs. 180612 peroxisomal membrane protein 3 (35kD, Ze 8. 10 457796 AA913389 Hs. 126691 ESTs 8. 10 429340 N35938 Hs. 199429 Homo sapiens mRNA ; cDNA DKFZp434M2216 (f 8. 10 445165 AV652831 gb : AV652831 GLC Homo sapiens cDNA clone 8. 08 418046 W49670 Hs. 56044 ESTs 8. 06 426269 H15302 Hs. 168950 Homo sapiens mRNA ; cDNADKFZp566A1046 (f 8. 04 439451 AF086270 Hs. 278554 heterochromatin-like protein 1 8. 02 419559 Y07828 Hs. 91096 ring finger protein 8. 02 409268 AA625304 Hs. 188554 ESTs 8. 00 447207 AA442233 Hs. 17731 hypotheticaf protein FW12892 8. 00 446977 AW863613 Hs. 156798 ESTs 8. 00 424565 AW102723 Hs. 75295 guanylate cyclase 1, soluble, alpha 3 8. 00 407013 U35637 gb : Human nebulin mRNA, partial cds 7. 99 414523 AU076633 Hs. 76353 serine (or cysteine) proteinase inhibito 7. 98 440637 AW900115 Hs. 7309 Homo sapiens clone 23741 mRNA sequence 7. 96 417076 AW973454 Hs. 238442 ESTs, Moderately similar to ALU7 HUMAN A 7. 95 425921 NM 007231 Hs. 162211 solute carrier family 6 (neurotransmitte 7. 94 415585 R59946 Hs. 184852 KIAA1553 protein 7. 92 453331 Al240665 Hs. 8895 ESTs 7. 92 445527 W39694 Hs. 83286 ESTs, Weakly similar to S14747 sphingomy 7. 90 417318 AW953937 Hs. 12891 ESTs 7. 90 429393 AA383024 Hs. 201603 Homo sapiens mRNA : cDNADKFZp434D0917 (f 7. 90 444769 A1191650 Hs. 221436 ESTs 7. 90 444272 A1138596 Hs. 154619 ESTs 7. 90 425264 AA353953 Hs. 20369 ESTs, Weakly similar to gonadotropin ind 7. 90 412642 BE244598 Hs. 809 hepatocyte growth factor (hepapoietin A ; 7. 90 453765 BE279901 Hs. 35091 hypothetical protein FLJ10775 7. 90 421558 AB011125 Hs. 105749 KIAA0553 protein 7. 90 446444 A1743737 Hs. 24370 ESTs 7. 90 420000 AB036063 Hs. 94262 p53-inducible ribonucleotide reductase s 7. 86 437237 BE513073 gb : 601171435F1 HMGC 15 Homo sapiens c 7. 86 409582 R27430 Hs. 271565 ESTs 7. 84 419235 AW470411 Hs. 288433 neurotrimin 7. 83 439620 AA838727 Hs. 124405 ESTs. Weakly similar to A46010 X-linked 7. 82 441690 R81733 Hs. 33106 ESTs 7. 80 417735 AA188175 Hs. 82506 KIAA1254 protein 7. 80 441795 N58115 Hs. 21137 AD024 protein 7. 80 442992 Api914699 Hs. 13297 ESTs 7. 80 422554 AA312219 Hs. 296338 ESTs 7. 80 423123 NM 012247 Hs. 124027 SELENOPHOSPHATE SYNTHETASE ; Human selen 7. 80 428627 BE002993 Hs. 187660 putative Rab5 GDP/GTP exchange factor ho 7. 80 429228 A1553633 Hs. 337139 ESTs 7. 80 429399 AA452244 Hs. 16727 ESTs 7. 80 436396 Api683487 Hs. 152213 wingless-type MMTV integration site fami 7. 77 455510 AA422029 Hs. 143640 ESTs, Weaklysimilartohyperpolarizatio 7. 76 429396 AW954598 Hs. 201626 Homo sapiens clone 25015 mRNA sequence 7. 76 453439 A1572438 Hs. 32976 guanine nucleotide binding protein 4 7. 75 410561 BE540255 Hs. 6994 Homo sapiens cDNA : FU22044 fis, clone H 7. 71 442875 BE623003 Hs. 23625 Homo sapiens clone TCCCTA00142 mRNA sequ 7. 71 428655 H05769 Hs. 188757 Homo sapiens, clone MGC : 5564, mRNA, comp 7. 70 413374 NM001034 Hs. 75319 ribonucleoUdereductaseM2polypeptide 7. 70 404996 NA 7. 70 418947 W52990 Hs. 22860 ESTs 7. 70 427401 U20582 Hs. 2149 affin like protein 7. 70 410748 BE383816 Hs. 12532 chromosome 1 open reading frame 21 7. 70 426262 Api792141 Hs. 196270 folate transporter/carrier 7. 70 446955 AW613138 Hs. 156747 ESTs 7. 70 449199 Api990122 Hs. 196988 ESTs 7. 70 443212 AW269515 Hs. 102500 hypothetical protein FW20481 7. 70 446155 At553695 Hs. 159422 Homo sapiens CDNA FU 13997 fis, clone Y7 7. 70 427164 AB037721 Hs. 173871 KIAA1300 protein 7. 70 452627 AN22843 Hs. 184319 ESTs, Weakly similar to KIAA1006 protein 7. 70 452588 AA889120 Hs. 110637 homeo box A10 7. 70 451838 AW005866 Hs. 193969 ESTs 7. 67 422956 BE545072 Hs. 122579 hypothetical protein FU10461 7. 66 451227 R84429 Hs. 151944 ESTs, Weakly similar to high-risk human 7. 66 450701 H39960 Hs. 288467 Homo sapiens cDNA FLJ12280 fis, clone MA 7. 65

432695 D63480 Hs. 278634 KIAA0146 protein 7. 63 447476 BE293466 Hs. 20880 ESTs, Weakly similar to 138022 hypotheti 7. 60 447289 AW247017 Hs. 36978 melanoma antigen, family A, 3 7. 60 447505 AL049266 Hs. 18724 Homo sapiens mRNA ; cDNA DKFZp564F093 (fr 7. 60 423065 R96158 Hs. 267130 Homo sapiens, clone MGC : 5406, mRNA, comp 7. 60 437396 BE140396 Hs. 21621 hypothetical protein DKFZp7620076 7. 60 450628 AW382884 Hs. 204715 ESTs 7. 60 418995 H39599 Hs. 294008 ESTs 7. 60 416402 NM_000715 Hs. 1012 complement component 4-binding protein, 7. 60 405545 NA 7. 60 440866 A1703103 Hs. 271360 hypothetical protein MGC16275 7. 60 421281 A1299139 Hs. 17517 ESTs 7. 60 424634 NM 003613 Hs. 151407 cartilage intermediate layer protein, nu 7. 60 421041 N36914 Hs. 14691 ESTs, Moderately similar to 138022 hypot 7. 60 453311 AW104911 Hs. 126707 hypotheticalproteinFlJ11457 7. 54 453060 AW294092 Hs. 21594 hypothetical protein MGC15754 7. 50 417655 AA780791 Hs. 14014 hypothetical protein FW14813 7. 50 417531 Nom-003157 Hs. 1087 sednelthreonine kinase 2 7. 50 444099 D87432 Hs. 10315 solute carrier family 7 (cationic amino 7. 50 407853 AA336797 Hs. 40499 dickkopf (Xenopus laevis) homolog 1 7. 50 408920 AL120071 Hs. 48998 fibronectinteucinerichtransmembranep 7. 50 447806 W03616 Hs. 10432 ESTs, Weakly similar to 138022 hypotheti 7. 48 424748 M346257 Hs. 134933 ESTs 7. 48 421089 AB037771 Hs. 101799 KIAA1350 protein 7. 46 444856 A1888057 Hs. 12097 ESTs 7. 42 447425 AI963747 Hs. 18573 acylphosphatase 1, erythrocyte (common) 7. 41 418450 R84397 Hs. 193651 ESTs, Weakly similar to altematively sp 7. 40 434539 AW748078 Hs. 214410 ESTs. Weakly similar to MUC2_HUMAN MUCIN 7. 40 437036 A1571514 Hs. 133022 ESTs 7. 40 414680 AA743331 Hs. 272572 hemoglobin, alpha 2 7. 40 451815 AW974911 Hs. 184793 HomosapienscDNA : FLJ21880 fis, clone H 7. 40 433577 AW007080 Hs. 8817 ESTs 7. 40 453652 AW009640 Hs. 28368 ESTs, Moderately similar to S65657 alpha 7. 40 422665 AJ011812 Hs. 119018 transcriptionfactorNRF 7. 40 424188 AW954552 Hs. 142634 zinc finger protein 7. 40 407300 AA102616 gb : zn43eO7. slStratageneHeLacells393 7. 40 431494 AA991355 Hs. 298312 hypothetical protein DKFZp434A1315 7. 40 452958 AA883929 Hs. 40527 ESTs 7. 40 418763 AK000219 Hs. 88367 hypothetical protein FW20212 7. 40 428279 AA425310 Hs. 155766 ESTs, Weakly similar to A47582 B-Cell gr 7. 40 449670 F07693 Hs. 23869 Homo sapiens mRNA ; cDNA DKFZp434K2172 (f 7. 40 449601 AA461509 Hs. 293565 ESTs, Weakly similar to putative p150 [H 7. 40 438490 AW593272 Hs. 301299 ESTs 7. 40 410044 BE566742 Hs. 58169 highly expressed in cancer, rich in leuc 7. 40 429509 AW614420 Hs. 204354 ras homolog gene family, member B 7. 38 433393 AF038564 Hs. 98074 itchy (mouse homolog) E3 ubiquitin prote 7. 38 434096 AW662958 Hs. 75825 pleiomorphic adenoma gene-like 1 7. 37 425773 N21279 Hs. 237749 ESTs 7. 36 422755 T25365 Hs. 119687 RAN binding protein 8 7. 36 410566 AA373210 Hs. 43047 Homo sapiens CDNA FU 13585 fis, clone PL 7. 35 412851 A1826502 Hs. 106149 ESTs 7. 35 418661 NM001949 Hs. 1189 E2F transcription factor 3 7. 35 436246 AW450963 Hs. 119991 ESTs 7. 34 433159 AB035898 Hs. 150587 kinesin-like protein 2 7. 33 444781 NM 014400 Hs. 11950 GPI-anchored metastasis-associated prote 7. 32 453878 AW964440 Hs. 19025 DC32 7. 31 414696 AF002020 Hs. 76918 Niemann-Pickdisease, bpeC1 7. 31 402250 AV655272 Hs. 20252 novel Ras family protein 7. 31 439039 A1656707 Hs. 48713 ESTs 7. 30 417976 BE565892 Hs. 83077 intedeukin 18 (interferon-gammainducin 7. 30 419436 AA991639 Hs. 242413 hypothetical protein DKFZp434K1421 7. 30 417006 AW673606 Hs. 80758 aspartyl-tRNAsynthetase 7. 30 425420 BE536911 Hs. 234545 hypothetical protein NUF2R 7. 30 425889 M57414 Hs. 161305 tachykinin receptor 2 7. 29 442969 A1025499 Hs. 132238 ESTs 7. 26 446360 N42553 Hs. 267914 homolog of mouse transient receptor pote 7. 25 438022 AW517524 Hs. 135201 NOD2 protein 7. 25 407183 AA358015 gb : EST66864 Fetal lung III Homo sapiens 7. 24 429882 AA278898 Hs. 225979 hypothetical protein similar to small G 7. 24 420120 AL049610 Hs. 95243 tranænptionelongafonfætorA (SII)-7. 22 400212 NA NA 7. 20 431812 AA515902 Hs. 130650 ESTs 7. 20 419481 A1879195 Hs. 90606 15 kDa selenoprotein 7. 20 447078 AW885727 Hs. 301570 ESTs 7. 20 413200 AA127395 Hs. 222414 ESTs 7. 20 411750 BE562298 Hs. 71827 KIAA0112 protein ; homolog ofyeast ribos 7. 20 439901 N73885 Hs. 124169 ESTs 7. 20 411815 AA156679 Hs. 125790 leucine-rich repeat-containing 2 7. 20 459279 AW814996 gb : MRi-ST0206-170400-024-h09 ST0206 Homo 7. 20 445263 H57646 Hs. 42586 KIAA1560 protein 7. 20 413801 M62246 Hs. 35406 ESTs, Highly similar to unnamed protein 7. 20 418407 AL044818 Hs. 84928 nuclear transcription factor Y, beta 7. 20 452221 C21322 Hs. 288057 hypotheticalprotein FLJ22242 7. 20

425202 AW962282 Hs. 152049 ESTs, Weakly similar to 138022 hypothe6 7. 20 403764 NA 7. 20 416896 A1752862 Hs. 5638 KIAA1572 protein 7. 20 416636 N32536 Hs. 42645 ESTs 7. 20 428071 AF212848 Hs. 182339 ets homologous factor 7. 20 450142 AW207469 Hs. 24485 chondroitin sulfate proteoglycan 6 (bama 7. 18 451017 BE391847 Hs. 181173 hypotheticalprotein MGC10771 7. 17 409759 N40285 Hs. 81182 histamineN-methyltransferase 7. 16 452448 AW182440 Hs. 61389 ESTs, Weakly similar to unnamed protein 7. 16 427951 Api826125 Hs. 43546 ESTs 7. 16 407939 W05608 Hs. 312679 ESTs, Weakly similar to A49019 dynein he 7. 15 419457 AA243146 Hs. 209334 ESTs, ModeratelysimilartoS23A_HUMANP 7. 12 411769 Al694575 Hs. 27207 KIAA0982 protein 7. 11 430355 NM 006219 Hs. 239818 phosphoinositide-3-kinase, catalytic, be 7. 10 419511 AA429750 Hs. 75113 generaltranscptionfactorIIlA 7. 10 409032 AW301807 Hs. 297260 ESTs 7. 10 424539 L02911 Hs. 150402 activin A receptor, type 1 7. 10 439221 AA737106 Hs. 32250 ESTs, Moderately similar to 178885 serin 7. 10 430719 AA488988 Hs. 293796 ESTs 7. 10 408020 AA127940 Hs. 62781 ESTs 7. 10 420218 AW958037 Hs. 286 ribosomal protein L4 7. 10 443487 A1073491 Hs. 269887 ESTs, HighlysimilartoKPBB_HUMANPHOSP 7, 10 414865 AA157155 Hs. 274414 hypothe§cal protein FU14457 7. 10 428724 AL390128 Hs. 191268 KIAA1530 protein 7. 10 413293 AL047483 Hs. 302498 GTP-binding protein homologous to Saccha 7. 10 419126 A1810144 Hs. 135276 ESTs 7. 09 437044 AL035864 Hs. 69517 cDNA for differenbally expressed C016 9 7. 09 433730 AK002135 Hs. 3542 hypotheúcaproteinFW11273 7. 07 417381 AF164142 Hs. 82042 solutecarrierfamily23 (nucleobasetra 7. 07 457019 AA421844 Hs. 12830 hypothetical protein 7. 07 409697 AB018348 Hs. 55947 KIAA0805 protein 7. 06 400977 NA NA 7. 06 436668 AA831857 Hs. 209071 ESTs 7. 03 451684 AF216751 Hs. 26813 CDA14 7. 03 404029 NA 7. 02 448719 AA033627 Hs. 21858 trinucleotde repeat containing 3 7. 02 445577 N40696 Hs. 137064 cytoplasmic polyadenylation element bind 7. 00 419647 AA348947 Hs. 91816 hypothetica) protein 7. 00 442075 AW136928 gb : UI-H-BI1-adp-d-08-0-Ul. sl NCl_CGAP_Su 7. 00 429598 AA811257 Hs. 269710 ESTs 7. 00 450832 AW970602 Hs. 105421 ESTs 7. 00 421389 AA531291 Hs. 101064 Homo sapiens cDNA FU12777 fis, clone NT 7. 00 453931 AL121278 Hs. 25144 ESTs 7. 00 432343 NM002960 Hs. 2961 S100 calcium-binding protein A3 7. 00 452979 AW167599 Hs. 232282 ESTs 7. 00 431696 AA259068 Hs. 267819 protein phosphatase 1, regulatory (inhib 7. 00 413583 AL120806 Hs. 5888 ESTs 7. 00 436758 AW977167 Hs. 155272 ESTs 7. 00 455944 BE160643 gb : PM1-HT0422-291299-002-f03HT0422Homo 6. 98 430302 AL137502 Hs. 238679 Rag D protein 6. 96 437613 R19892 Hs. 10267 MIL1 protein 6. 96 440524 R71264 Hs. 16798 ESTs 6. 95 451047 AB022317 Hs. 25887 sema domain, immunoglobulin domain (Ig), 6. 93 450377 AB033091 Hs. 74313 Kit1265 protein 6. 93 457396 Z20964 Hs. 323817 DKFZP547E1010protein 693 417393 R10484 Hs. 82071 Cbp/p300-interac6ng transactivator, wit 6. 92 414417 BE299433 Hs. 68533 KIAA1679 protein 6. 92 412246 AI160873 Hs. 69233 zinc finger protein 6. 90 411003 AA181018 Hs. 13056 hypothetiea) protein FW13920 6. 90 413833 Z15005 Hs. 75573 centromere protein E (312kD) 6. 90 405696 NA NA 6. 90 431689 AA305688 Hs. 267695 UDP-Gal : betaGIcNAc beta 1, 3-galactosyltr 6. 90 414429 R51494 Hs. 71818 ESTs 6. 90 424641 AB001106 Hs. 151413 glia maturation factor, beta 6. 90 418895 AA894638 Hs. 14600 ESTs 6. 90 445900 AF070526 Hs. 13429 Homo sapiens clone 24787 mRNA sequence 6. 90 446006 NM004403 Hs. 13530 deafness, autosomal dominant 5 6. 90 432038 AA524746 Hs. 162110 ESTs 6. 87 446610 AV659433 Hs. 282984 ESTs. Weakly similar to 138022 hypotheti 6. 86 451286 AW139789 Hs. 16370 Homo sapiens CDNA FLJ 11652 fis, clone HE 6. 86 408915 NM_016651 Hs. 48950 heptacellular carcinoma novel gene-3 pro 6. 85 418934 T83845 Hs. 191116 ESTs 6. 82 435143 R12375 Hs. 194600 ESTs 6. 82 442660 AW138174 Hs. 130651 ESTs 6. 82 432729 AK000292 Hs. 278732 hypothetical protein FU20285 6. 81 435990 A1015862 Hs. 131793 ESTs 6. 80 449062 AJ272268 Hs. 22958 calcium channel, voltage-dependent, alph 6. 80 453688 AW381270 Hs. 194110 hypothetical protein PR02730 6. 80 421476 AW953805 Hs. 21887 ESTs 6. 80 430510 AW162916 Hs. 241576 hypothetical protein PR02577 6. 80 409045 AA635062 Hs. 50094 Homo sapiens mRNA ; cDNADKFZp43400515 (f 6. 80 410298 At693821 Hs. 182185 ESTs 6. 80 420560 AW207748 Hs. 59115 ESTs 6. 80

427752 AA470687 Hs. 104772 ESTs 6. 80 414080 AA135257 Hs. 47783 Baggressivelymphomagene 6. 80 422420 U03398 Hs. 1524 tumor necrosis factor (ligand) superfami 6. 80 416913 AW934714 gb : RC1-DT0001-031299-011-a11 DT0001 Homo 6. 80 426890 AA393167 Hs. 41294 ESTs 6. 80 411773 NM 006799 Hs. 72026 protease, serine. 21 (testsin) 6. 80 413328 Y15723 Hs. 75295 guanylate cyclase 1, soluble, alpha 3 6. 79 437619 AW351491 Hs. 334853 hypothetical protein FU23544 6. 79 434267 A1206589 Hs. 116243 ESTs 6. 79 419358 T78763 Hs. 90063 neurocaldn delta 6. 79 435854 AJ278120 Hs. 4996 putative ankyrin-repeat containing prote 6. 78 424925 NM002432 Hs. 153837 myeioidcetinudear differentiation ant 6. 77 443184 A1638728 Hs. 131973 ESTs 6. 77 444484 AK002126 Hs. 11260 hypothetical protein F1. 111264 6. 77 429483 AA974832 Hs. 128708 ESTs 6. 76 425605 BE544300 Hs. 7076 KIAA1705 protein 6. 76 425045 AW953186 Hs. 92400 ESTs 6. 76 438776 AW245243 Hs. 334368 hypothetical protein MGC1 1257 6. 75 458174 AA781530 Hs. 127236 hypothetical protein FLJ12879 6. 74 445129 R39878 Hs. 21394 ESTs 6. 74 435532 AW291488 Hs. 117305 Homo sapiens, clone IMAGE : 3682908, mRNA 6. 73 444442 A1149234 Hs. 298423 ESTs, Moderately similar to 154374 gene 6. 73 431240 AA496790 Hs. 179481 ESTs 6. 72 422109 S73265 Hs. 1473 gastrin-releasing peptide 6. 70 416655 AW968613 Hs. 79428 BCL2/adenovinus E1B 19kD-interæúng pro 6. 70 423811 AW299598 Hs. 50895 homeo box C4 6. 70 443695 AW204099 Hs. 337720 ESTs, Weakly similar to AF126780 1 retn 6. 70 420686 A1950339 Hs. 40782 ESTs 6. 70 419574 AK001989 Hs. 91 165 hypothetical protein 6. 70 418269 AA806113 Hs. 189025 ESTs 6. 70 434164 AW207019 Hs. 148135 serine/threonine kinae 33 6. 70 408660 AA525775 Hs. 292523 ESTs, Moderately similar to PC4259 feni 6. 70 453370 A1470523 Hs. 139336 ATP-binding cassette, sub-family C (CFTR 6. 70 409506 Nom006153 Hs. 54589 NCK adaptor protein 1 6. 70 454029 W05150 Hs. 37034 homeo box A5 6. 70 413365 AW205188 Hs. 124304 Homo sapiens DNA FLJ14635 fis, clone NT 6. 70 447247 AW369351 Hs. 287955 Homo sapiens cDNA FW13090 fis, clone NT 6. 70 426566 AF131836 Hs. 170453 tropomodulin 6. 70 446261 AA313893 Hs. 306219 hypothetical protein FU 12615 similar to 6. 70 408547 AA574291 Hs. 57837 ESTs 6. 70 430458 AA479300 Hs. 225706 ESTs, Weakly similar to 138022 hypotheb 6. 70 413627 BE182082 Hs. 246973 ESTs 6. 70 410498 AA355749 gb : EST64459JurkatT-cellsVI Homosapie 6. 70 434015 AA844518 Hs. 300876 hypothe6cal protein FU13386 6. 70 453691 H12235 Hs. 226505 ESTs 6. 68 415068 Z19448 Hs. 131887 ESTs, Weakly similar to T24396 hypotheti 6. 68 415885 D79983 Hs. 78894 KIAA0161 gene product 6. 68 405529 AW410458 Hs. 5258 chromosome 11 open reading frame2 6. 68 438242 AW241910 Hs. 122254 ESTs, Weakly similar to JX0369 collagen 6. 68 442643 U82756 Hs. 8551 PRP4/STK/WD splicing factor 6. 67 424802 X79201 Hs. 153221 synovial sarcoma, translocated to X chro 6. 67 415007 BE244332 Hs. 77770 adaptor-related protein complex 3, mu 2 6. 67 458714 R20916 Hs. 202501 ESTs 6. 66 414591 A1888490 Hs. 55902 ESTs, Weakly similar to ALU8_HUMAN ALU S 6. 65 433260 AB040966 Hs. 83575 KIAA1533 protein 6. 65 400268 NA NA 6. 63 453180 N46243 Hs. 110373 ESTs, HighlysimilartoT42626secreted 6. 62 403973 NA NA 6. 60 436862 Api821940 Hs. 264622 ESTs, Moderately similar to ALUN HUMAIN A 6. 60 428046 AW812795 Hs. 155381 ESTs, Moderately similar to 138022 hypot 6. 60 453387 A1990741 Hs. 252809 ESTs 6. 60 424084 Api940675 Hs. 20914 hypothetical protein FLJ23056 6. 60 418444 AI902899 Hs. 85155 butyrate response factor 1 (EGF-response 6. 60 448172 N75276 Hs. 135904 ESTs 6. 60 409571 AA504249 Hs. 187585 ESTs 6. 60 423025 AA831267 Hs. 12244 hypothetical protein FU20097 6. 60 430701 A1760833 Hs. 293971 ESTs 6. 60 450373 A1915790 Hs. 337282 ESTs 6. 60 419384 AA490866 Hs. 39429 ESTs 6. 60 429828 AB019494 Hs. 225767 IDN3 protein 6. 60 441761 AI222880 gb : qp4OcO6. x1 NCl_CGAR_Co3Homosapiens 6. 60 411048 AK001742 Hs. 67991 hypothetical protein DKFZp434G0522 6. 60 421111 BE299047 Hs. 43532 ESTs, Weakly similar to T20177 hypotheti 6. 60 407424 AF120493 gb : Homo sapiens etastaset precursor (EL 6. 59 412396 AW947895 gb : PM1-MT0010-200300-001-flO MT0010 Homo 6. 57 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h 6. 57 406674 AA332152 Hs. 288036 tRNAisopentenylpyrophosphateuansfera 6. 57 400860 NA 6. 56 457893 AA744292 gb : ny5ldO5. s1 NCI CGAP_PrlBHomosapiens 6. 55 426108 AA622037 Hs. 166468 programmed cell death 5 6. 54 422133 AW612779 Hs. 333159 Homo sapiens laryngeal carcinoma related 6. 54 421044 AF061871 Hs. 311736 Human DNA sequence from clone RP1-238D15 6. 54 414136 AA812434 Hs. 119023 SMC2 (structural maintenance of chromoso 6. 53

400351 AF060169 Hs. 272369 HomosapiensAS11proteinmRNA, paoa 6. 52 413670 AB000115 Hs. 75470 hypothetical protein, expressed in osteo 6. 52 410416 BE410072 Hs. 63304 protein phosphatase methylesterase-1 6. 50 419852 AW503756 Hs. 286184 hypothetical protein dJ551D2. 5 6. 50 419677 N77342 Hs. 21851 Homo sapiens cDNA FLJ 12900 fis, clone NT 6. 50 431806 AF186114 Hs. 270737 tumor necrosis factor (ligand) superfami 6. 50 429774 Api522215 Hs. 50883 KIAA1804 protein 6. 50 428228 AA424352 Hs. 210586 ESTs 6. 50 418134 AA397769 Hs. 86617 ESTs 6. 50 403859 NA NA 6. 50 422704 AA972147 Hs. 132275 ESTs 6. 50 416737 AF154335 Hs. 79691 LIM domain protein 6. 50 429854 R55508 Hs. 99472 ESTs 6. 50 422672 X12784 Hs. 119129 collagen, type IV, alpha 1 6. 49 453600 BE246211 Hs. 119120 E3 ubiquifin ligase SMURFL 6. 48 454835 AW833763 gb : QV4-TT0008-130100-077-d10TT0008Homo 6. 48 434603 AF147384 gb : Homo sapiens length insert cDNA 6. 48 408243 Y00787 Hs. 624 interieukin8 6. 48 429317 AA831552 Hs. 268016 Homo sapiens cDNA : FLJ21243 fis, clone C 6. 47 451316 A1770011 Hs. 208310 ESTs 6. 46 448339 AL035920 Hs. 20938 RNA binding motif, single stranded inter 6. 46 433423 BE407127 Hs. 8997 heat shock 70kD protein 1A 6. 44 410358 AW975168 Hs. 13337 ESTs, Weakly similar to unnamed protein 6. 44 434025 AF114264 Hs. 216381 HomosapienscloneHH409unknownmRNA 6. 42 440526 A1832243 Hs. 211471 ESTs 6. 42 432727 AA305233 Hs. 278712 eukaryotic translation initiation factor 6. 41 433009 AA761668 gb : nz24cO8. sl NG_CGAP GCB1 Homo sapiens 6. 40 435782 N49433 Hs. 285737 Homo sapiens cDNA FW20895 fis, done A 6. 40 415071 AK002197 Hs. 284270 Homo sapiens CONA FU 11335 fis, clone PL 6. 40 407162 N63855 Hs. 142634 zinc finger protein 6. 40 446152 A1292036 Hs. 150028 ESTs 6. 40 422828 AL133396 Hs. 121281 pdon protein 2 (dublet) 6. 40 418866 T65754 gb : ycl lc07. si Stratagene lung (937210) H 6. 40 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAA1330 protein 6. 40 429039 A1524793 Hs. 301897 ESTs 6. 40 447254 NM 004153 Hs. 17908 origin recognition complex, subunit 1 (y 6. 40 435159 AA668879 Hs. 116649 ESTs 6. 40 429625 AA455568 Hs. 193814 ESTs 6. 40 430180 AA331406 Hs. 75456 A kinase (PRKA) anchor protein 10 6. 40 408420 NM006915 Hs. 44766 netiniUs pigmentosa 2 (X-linked recessi 6. 40 426572 AB037783 Hs. 170623 hypothetical protein FLJ11183 6. 40 449911 Ai262106 Hs. 12653 ESTs 6. 40 440105 AA694010 Hs. 6932 Homo sapiens clone 23809 mRNA sequence 6. 40 440395 AA884412 Hs. 216342 ESTs 6. 37 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactin) 6. 37 417771 AA804698 Hs. 82547 retinoic acid receptor responder (tazaro 6. 36 417092 H97508 Hs. 181165 eukaryotictranstationebngation factor 6. 36 412227 AW902282 gb : QV3-NN1023-260400-169-glO NN1023 Homo 6. 36 400845 NA 6. 36 403546 NA NA 6. 36 412345 AW938386 gb : PM4-DT0057-201299-002-G10 DT0057 Homo 6. 35 422186 AW962364 Hs. 129051 ESTs 6. 34 426990 AL044315 Hs. 173094 Homo sapiens mRNA for KIAA1750 protein, 6. 34 417687 A1828596 Hs. 250691 ESTs 6. 33 426223 AW977812 Hs. 130391 ESTs 6. 32 417588 Z44510 gb : HSC22D091 normalized infant brain cDN 6. 32 432629 AW860548 Hs. 280658 ESTs 6. 31 440495 AA887212 Hs. 14161 hypotheticalprotein DKFZp43411930 6. 31 407771 AL138272 Hs. 62713 ESTs 6. 31 417517 AF001176 Hs. 82238 POP4 (processing of precursor, S. cerev 6. 30 431041 AA490967 Hs. 197955 KIAA0704 protein 6. 30 445571 A1378000 Hs. 158489 ESTs, Weak) y similar to Z1 84_HUMAN ZINC 6. 30 433309 AA807060 Hs. 126558 ESTs 6. 30 415659 W27214 Hs. 78547 zinc finger protein (clone 647) 6. 30 420271 Api954365 Hs. 42892 ESTs 6. 30 426921 AA037145 Hs. 172865 cleavage stimulaGon factor, 3'pre-RNA, 6. 30 400950 NA NA 6. 30 429692 N48422 Hs : 9977 ESTs, Weakly similar to B34087 hypotheti 6. 30 439813 AA846321 Hs. 124501 ESTs 6. 30 449444 AW818436 Hs. 23590 solute carrier famity 16 (monocarboxytic 6. 30 453596 AA441838 Hs. 62905 hypothetical protein FLJ14834 630 446847 T51454 Hs. 82845 Homo sapiens cDNA : FLJ21930 fis, clone H 6. 30 435820 AA700580 Hs. 189000 ESTs 6. 30 452576 AB023177 Hs. 29900 KIAA0960 protein 6. 30 448924 AW450569 Hs. 188399 ESTs 6. 30 424343 AW956360 Hs. 4748 adenyiatecydase activating poiypeptide 6. 30 412591 BE217736 Hs. 292653 ESTs, Weakly similar to T26845 hypotheti 6. 30 426642 AW068223 Hs. 171581 ubiquiGn G-terminai hydrolase UCH37 6. 30 419088 A1538323 Hs. 52620 integnn, beta 8 6. 30 401424 NA 6. 30 412189 R60982 Hs. 22581 ESTs 6. 30 435501 AW051819 Hs. 129908 KIAA0591 protein 6. 30 408221 AA912183 Hs. 47447 ESTs 6. 28

413943 AW294416 Hs. 144687 HomosapienscDNAFW12981fis, cloneNT 6. 28 416845 H95279 gb : yu20hO2. sl Soaresfetalliverspleen 6. 27 402732 NA NA 6. 26 413224 Api732470 Hs. 191157 ESTs, Weakly similar to ALU7 HUMAN ALU S 6. 24 415642 U19878 Hs. 336224 transmembrane protein with EGF-like and 6. 24 449284 BE502240 Hs. 38592 hypotheticalprotein FLJ23342 6. 24 419548 AW978142 Hs. 326248 HomosapienscDNA : FW22071fis, cloneH 6. 23 453880 Api803166 Hs. 28462 ESTs, Weakly similar to 138022 hypotheb 6. 22 422675 BE018517 Hs. 119140 eukaryotic translationinitiationfactor 6. 22 413384 NM 000401 Hs. 75334 exostoses (multiple) 2 6. 21 445584 AF217518 Hs. 8360 PTD012 protein 6. 21 451065 AW295132 Hs. 222231 ESTs, Weakly similar to granule cell mar 6. 21 420807 AA280627 Hs. 57846 ESTs 6. 20 421155 H87879 Hs. 102267 lysyl oxidase 6. 20 441421 AA356792 Hs. 334824 hypothetical protein FLJ14825 6. 20 440209 H05049 Hs. 22269 neurexin 3 6. 20 408170 AW204516 Hs. 31835 ESTs 6. 20 433590 N98410 Hs. 48364 Homo sapiens regulator of G-protein sign 6. 20 442008 A1457814 Hs. 270272 ESTs 6. 20 420617 AK001652 Hs. 99423 ATP-dependent RNA helicase 6. 20 402343 NA 6. 20 432682 A1376400 Hs. 159588 ESTs 6. 20 452109 A1525873 Hs. 61164 hypothetical protein FU14909 6. 20 429954 A1918130 Hs. 21374 ESTs 6. 20 417256 U94332 Hs. 81791 tumor necrosis factor receptor superfami 6. 20 435525 Al831297 Hs. 123310 ESTs 6. 20 413604 R51767 gb : yg73g11. r1 Soaresinfantbrån 1NIBH 6. 20 425305 AA363025 Hs. 155572 Human clone 23801 mRNA sequence 6. 20 443285 A1301918 Hs. 334264 ESTs 6. 20 446565 D13757 Hs. 311 phosphonbosy ! pyrophosphateamidotransf 6. 20 451027 AW519204 Hs. 40808 ESTs 6. 20 452243 AL355715 Hs. 28555 programmed cell death 9 6. 19 429782 NM 005754 Hs. 220689 Ras-GTPase-activaGng protein SH3domain 6. 17 424060 X92108 Hs. 138629 H. sapiens mRNA for subtelomeric repeat s 6. 17 432494 AA551060 gb : nk74f02. s1 NCI_CGAP_Sch1 Homosapiens 6. 16 448186 AA262105 Hs. 4094 Homo sapiens cDNA FU14208 fis, clone NT 6. 14 419638 N46504 Hs. 91747 profiles 2 6. 13 445595 W25950 Hs. 14512 DIPB protein 6. 13 433036 AA574091 Hs. 105964 ESTs 6. 13 457155 AL110243 Hs. 187991 DKFZP564A122protein 6. 13 443715 A1583187 Hs. 9700 cyclin E1 6. 13 422867 L32137 Hs. 1584 cartitageoiigomeric matrix protein (pse 6. 12 453286 AA034319 Hs. 29041 HomosapienscDNAFLJ14177fis, cloneNT 6. 11 424897 D63216 Hs. 153684 fnzzled-relatedpnztein 6. 11 429188 AB011171 Hs. 198037 KIAA0599 protein 6. 11 434894 AW977850 Hs. 23856 hypothetical protein MGC5297 6. 10 413339 A1818080 Hs. 194290 ESTs 6. 10 453685 AL110309 gb : DKFZp564L0278J1564 (synonym : hfbr2) 6. 10 421195 BE464560 Hs. 133017 ESTs 6. 10 453296 AA034413 Hs. 62560 ESTs 6. 10 444985 A1677737 Hs. 28329 hypothetical protein FU14005 6. 10 423492 AF020761 Hs. 129683 ubiquitin-conjugating enzyme E2D 1 (homo 6. 10 419841 BE005848 Hs. 7326 ESTs 6. 10 429190 H18650 Hs. 92602 ESTs 6. 10 426116 AA868729 Hs. 144694 ESTs 6. 10 451441 AA017601 Hs. 84529 ESTs, WeaklysimilartoZ202_HUMANZINC 6. 10 401740 NA 6. 10 441953 H11695 Hs. 322901 disnupterofsilencinglO 6. 10 401464 AF039241 Hs. 9028 histone deacetylase 5 6. 10 405033 NA 6. 10 410743 AA089474 Hs. 272153 ESTs 6. 10 454758 AW845266 gb : lL2-CT0031-16099-003-B08 CT0031 Homo 6. 10 417728 AW138437 Hs. 24790 KIAA1573 protein 6. 10 418553 T88964 gb : yd97aO7. rl Soares fetal liver spleen 6. 09 431617 AK000738 Hs. 264636 hypothetical protein FU20731 6. 08 455608 BE011437 gb : CM4-BN0220-080500-170-f03BN0220Homo 6. 08 450755 AA010984 Hs. 159464 ESTs 6. 07 455217 AW867534 gb : MRO-SN0037-160400-004-e05 SN0037 Homo 6. 07 437179 AA393508 Hs. 300642 serologically defined colon cancer antig 6. 06 408622 AA056060 Hs. 202577 Homo sapiens CDNA FU12166 fis, clone MA 6. 06 415308 F05251 gb : HSC04H101 normalized infant brain cDN 6. 06 428417 AK001699 Hs. 184227 F-box only protein 21 6. 05 426501 AW043782 Hs. 293616 ESTs 6. 03 431077 A1669133 Hs. 115660 hypothetical protein FU12810 6. 03 403040 NA 6. 02 445704 A1493742 Hs. 165210 ESTs, Moderately similar to 138022 hypot 6. 02 415637 R25517 gb : yg44fO1. (l Soares infant brain I NIB H 6. 02 427925 N51323 Hs. 255935 Homo sapiens, clone IMAGE : 3448993, mRNA 6. 02 404702 NA NA 6. 02 433183 AF231338 Hs. 222024 transcription factor BMAL2 6. 01 437762 T78028 Hs. 154679 synaptotagmin 1 6. 01 443833 A1654108 Hs. 135125 ESTs 6. 01 422263 AA307639 Hs. 129908 KIAA0591 protein 6. 00

420909 Api640551 Hs. 88878 Homo sapiens cDNA : FU23536 fis, clone L 6. 00 407612 U26403 Hs. 37142 ephnn-A5 6. 00 450715 Api266484 Hs. 31570 ESTs, Weakly similar to KIAA1324 protein 6. 00 453853 AL040600 Hs. 188083 ESTs 6. 00 444188 Api393165 Hs. 699 peptidylprolyl isomerae B (cyclophilin 6. 00 451813 NM 016117 Hs. 27182 phospholipase A2-activating protein 6. 00 422505 AL120862 Hs. 124165 ESTs 6. 00 420734 AW972872 Hs. 293736 ESTs 6. 00 455082 BE148180 gb : RCO-HT0232-211099-011-eO4HT0232Homo 6. 00 444200 AA327113 Hs. 149057 ESTs 6. 00 447432 AW958473 Hs. 301957 nudixfnucteosidediphosphate (inked moi 6. 00 419752 AA249573 Hs. 152618 ESTs, Moderately similar to ZN91 HUMAN Z 6. 00 428412 AA428240 Hs. 126083 ESTs 6. 00 407790 Al027274 Hs. 288941 Homo sapiens cDNA FU 14866 fis, clone PL 6. 00 428945 AW192803 Hs. 98974 ESTs, Weakly similar to S65824 reverse t 6. 00 431878 AA521207 Hs. 270202 ESTs, Weakly similar to ALU4 HUMAN ALU S 6. 00 425282 AW163518 Hs. 155485 hunfingbn interacting protein 2 6. 00 401093 NA 6. 00 411861 AW867875 gb : MRO-SN0040-050500-003fil SN0040Homo 6. 00 411800 N39342 Hs. 103042 micmtubule-associated protein 1B 5. 99 446925 AW974605 Hs. 176669 ESTs 5. 98 401708 NA NA 5. 98 449894 AK001578 Hs. 24129 CLLL7 protein 5. 97 403278 NA NA 5. 96 455212 AW866330 gb : QV4-SN0024-080400-167-e01 SN0024 Homo 5. 96 410116 AW630671 Hs. 58636 squamouscei ! carcinoma antigen recogniz 5. 96 441271 AA927290 Hs. 130462 ESTs 5. 95 404072 NA 5. 95 431596 T34708 Hs. 272927 Sec23 (S. cerevisiae) homolog A 5. 94 421622 AB037748 Hs. 106204 KIAA1327 protein 5. 93 441300 R35063 Hs. 181536 ESTs 5. 92 445517 AF208855 Hs. 12830 hypothetical protein 5. 91 429559 Api985345 Hs. 26425 ESTs 5. 91 443767 BE562136 Hs. 9736 proteasome (prosome, macropain) 26S subu 5. 91 440510 H08427 Hs. 309165 ESTs, Weakly similar to ISHUSS protein d 5. 90 414727 BE466904 gb : hz28hO3. xl NCI_CGAP_GC6 Homo sapiens 5. 90 451686 AA059246 Hs. 110293 ESTs 5. 90 438032 BE045624 Hs. 152992 ESTs 5. 90 450470 Z75330 Hs. 286148 stromal antigen 1 5. 90 430533 AA480895 Hs. 201552 ESTs, Weakly similar to Ti 7288 hypotheti 5. 90 432662 AL049314 Hs. 280700 ESTs 5. 90 451742 T77609 Hs. 117970 ankyrin 2, neuronal 5. 90 431217 NM 013427 Hs. 250830 Rho GTPase activating protein 6 5. 90 412537 AL031778 Hs. 797 nuclear transcription factor Y, alpha 5. 90 447233 AW246333 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 5. 90 410804 U64820 Hs. 66521 Machado-Joseph disease (spinocerebellar 5. 90 452619 AW298597 Hs. 61884 Homo sapiens, clone IMAGE : 4298026, mRNA, 5. 90 433865 N29862 Hs. 44104 ESTs 5. 90 453403 BE466639 Hs. 61779 Homo sapiens cDNA FW13591 fis, clone PL 5. 90 448743 AB032962 Hs. 21896 KIAA1136 protein 5. 90 447153 AA805202 Hs. 315562 ESTs 5. 90 425793 AA363946 Hs. 20969 ESTs 5. 90 404632 NA 5. 90 446364 AB006624 Hs. 14912 KIAA0286 protein 5. 90 452240 A1591147 Hs. 61232 ESTs 5. 90 410424 AA084984 gb : znilaO8. rl StratagenehNTneuron (937 5. 90 404170 NA 5. 89 458390 Api792585 Hs. 133272 ESTs. WeaklysimilartoALUC_HUMAN ! ! ! ! 5. 89 408296 AL117452 Hs. 44155 DKFZP586G1517 protein 5. 88 444406 A1147237 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 5. 87 413894 BE177983 gb : RC3-HT0600-230300-021-g10 HT0600 Homo 5. 87 453922 AF053306 Hs. 36708 budding uninhibited by benzimidazoles 1 5. 86 446700 AW206257 Hs. 156326 HumanDNAsequenceíromcloneRP11-145L2 5. 86 443377 Al792547 Hs. 133292 ESTs 5. 86 419162 AA234591 Hs. 304123 ESTs 5. 85 436608 AA628980 Hs. 192371 down syndrome critical region protein DS 5. 84 428650 A1560456 Hs. 107319 ESTs 5. 84 437410 AW023340 Hs. 14880 ESTs 5. 84 428303 AW974476 Hs. 183601 regulator of G-protein signalling 16 5. 84 401004 NA 5. 83 414504 AW069181 Hs. 115175 stedle-alpha motif and leucine zipper c 5. 83 410979 BE151480 gb : RCO-HT0295-071199-011-aO1 HT0235Homo 5. 82 424576 BE154142 Hs. 96833 ESTs 5. 82 439352 BE614347 Hs. 169615 hypothetical protein FU20989 5. 81 423057 AW961597 Hs. 130816 ESTs. Moderately similar to 138022 hypot 5. 80 429250 H56585 Hs. 198308 tryptophan rich basic protein 5. 80 413048 M93221 Hs. 75182 mannose receptor, C type 1 5. 80 451367 AA923729 Hs. 26322 cell cycle related kinase 5. 80 418647 AA226198 gb : nc26a07. sl NCl_CGAP_Prl Homosapiens 5. 80 421589 AW954177 Hs. 82919 cullin 2 5. 80 427969 NMJX) 1963 Hs. 2230 epidermal growth factor (beta-urogastron 5. 80 451406 A1694320 Hs. 6295 ESTs, Weakly similar to T17248 hypotheti 5. 80 436096 H55931 Hs. 269582 ESTs 5. 80

443353 A1052659 Hs. 133255 ESTs 5. 80 457244 AA581385 Hs. 162473 ESTs, Weakly similar to 138022 hypotheti 5. 80 407746 AK001962 Hs. 38114 hypothetical protein FLJ11100 5. 80 440688 AW404591 Hs. 147440 ESTs, Weakly similar to Z192_HUMAN ZINC 5. 80 445745 AB007924 Hs. 13245 KIAA0455 gene product 5. 80 405637 NA NA 5. 80 415293 R49462 Hs. 106541 ESTs 5. 80 440404 A1015881 Hs. 324527 mitochondriatribosomai protein S5 5. 80 442227 AW771958 Hs. 175437 ESTs, Moderately similar to PC4259 fem 5. 80 423395 AA326613 gb : EST29922 Cerebellum II Homo sapiens c 5. 80 410555 U92649 Hs. 64311 adisintegrinandmetalloproteinaedoma 5. 80 416000 R82342 Hs. 79856 ESTs, Weakly similar to S65657 alpha-lC-5. 80 422108 AA297914 Hs. 111749 postmeiotic segregation increased (S. ce 5. 80 430818 Al311928 gb : qo89h04. x1 NCl_CGAP_KidS Homo sapiens 5. 80 444749 A1190672 Hs. 65926 ESTs 5. 80 417515 L24203 Hs. 82237 ataxia-telangiectasia group D-associated 5. 79 456192 D84109 Hs. 80248 RNA-binding protein gene with multiples 5. 78 411253 AW833897 gb : OVO-TTOOO9-111199-055-bO7TT0009Homo 5. 78 417219 AW973473 Hs. 220936 ESTs 5. 78 409450 AW628650 Hs. 61260 hypothetical protein FU13164 5. 76 412013 AA400753 Hs. 43761 ESTs, Weakly similar to A46010 inked 5. 76 425566 AW162943 Hs. 250618 UL16 binding protein 2 5. 75 417877 A1025829 Hs. 86320 ESTs 5. 75 437114 AA836641 Hs. 163085 ESTs 5. 75 421238 AB033101 Hs. 102796 Homo sapiens cDNA FW 10708 fis, clone NT 5. 74 428959 AF100779 Hs. 194680 WNT1 inducible signaling pathway protein 5. 73 415209 F00183 Hs. 172004 titin 5. 73 429922 Z97630 Hs. 226117 Hl histone family, member 0 5. 72 420022 AA256253 Hs. 120817 ESTs 5. 71 431485 BE621320 Hs. 257486 hypothetical protein FLJ20062 5. 71 424304 NM_001395 Hs. 144879 dual specificity phosphatase 9 5. 71 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 5. 71 438085 R52518 Hs. 7967 ESTs 5. 70 444379 N99035 Hs. 222657 ESTs 5. 70 401348 NA NA 5. 70 428878 AA436884 Hs. 48926 ESTs 5. 70 422564 A1148006 Hs. 222120 ESTs 5. 70 452560 BE077084 Hs. 336432 ESTs 5. 70 408384 BE144344 Hs. 7589 ESTs, Weakly similar to A46010 X-linked 5. 70 409948 AA078643 gb : 7P08B01 Chromosome 7 Placental cDNA L 5. 70 421166 AA305407 Hs. 102308 potassium inwardly-rectifying channel, s 5. 70 439231 AW581935 Hs. 141480 Homo sapiens mRNA ; cDNA DKFZp434N079 (fr 5. 70 439203 AA448930 Hs. 8453 KIAA1587 protein 5. 70 442029 AW956698 Hs. 14456 neural precursor cell expressed, develop 5. 70 451922 BE463995 Hs. 211033 ESTs 5. 70 407808 AA663559 Hs. 279789 histone deacetylase 3 5. 70 428161 M96954 Hs. 182741 TIA1 cytotoxic granule-asociated RNA-bi 5. 70 413430 R22479 Hs. 167073 HomosapienscDNAFW13047fis, cloneNT 5. 70 428223 AA424313 Hs. 98402 ESTs 5. 70 427972 AA864870 Hs. 181304 putative gene product 5. 70 416283 Nom-005429 Hs. 79141 vascular endothelial growth factor C 5. 70 416319 A1815601 Hs. 79197 CD83 antigen (activated B lymphocytes, i 5. 70 458044 AW979114 Hs. 326135 ESTs 5. 70 432911 AW807634 Hs. 279799 putative zinc finger protein NY-REN-34 a 5. 70 411643 A1924519 Hs. 192570 hypothetical protein FLJ22028 5. 70 408867 AA437199 Hs. 656 cell division cycle 25C 5. 70 428679 AA431765 gb : zw80c03. sl Soares_tesUs_NHTHomosap 5. 70 428822 W28418 Hs. 30715 potassium voltage-gated channel, Isk-rel 5. 70 409570 AW418720 Hs. 167583 ESTs 5. 70 457441 BE467737 Hs. 146125 ESTs 5. 70 409101 NM 004297 Hs. 50612 guanine nucleotide binding protein (G pr 5. 70 420192 AA256281 Hs. 105040 ESTs 5. 69 423582 BE000831 Hs. 23837 HomosapienscDNAFW11812fis, cloneHE 5. 69 454511 AW948146 gb : RCO-MT0013-280300-031-eO2MTW13Homo 5. 68 419586 A1088485 Hs. 144759 ESTs, Weakly similar to 138022 hypotheti 5. 67 416777 AF146760 Hs. 79844 DKFZP564M1416 protein 5. 67 435849 BE305242 Hs. 16098 claudin 2 5. 67 457892 AA744389 gb : ny51e10. sl NCl_CGAP_Prl8Homosapiens 5. 66 450191 AW137243 Hs. 222446 ESTs 5. 66 438653 AW188099 Hs. 131813 ESTs 5. 66 422910 Api269508 Hs. 121591 Human DNA sequence from PAC 257A7 on chi 5. 66 453694 AW504918 Hs. 258208 Homo sapiens, clone MGC : 15606, mRNA, com 5. 66 445302 AK001537 Hs. 12488 hypothetical protein FU10675 5. 66 446080 A1221741 Hs. 117777 ESTs 5. 65 425474 Z48054 Hs. 158084 peroxisome receptor 1 5. 65 432542 AW083920 Hs. 16098 claudin 2 5. 65 446983 AA157484 Hs. 97199 complementcomponentClqreceptor 5. 65 420898 A8002379 Hs. 100113 KIAA0381 protein 5. 65 401372 NA 5. 64 428541 Al862570 Hs. 299214 Homo sapiens, clone IMAGE2822295, mRNA, 5. 63 426249 F05422 Hs. 168352 nucleoporin-like protein 1 5. 63 459705 BE082764 Hs. 270252 ESTs. Weakly similar to androgen recepto 5. 63 451863 AL120634 Hs. 305923 ATPase. Cavtransporting. piamamembra 5. 62

426316 NM_002430 Hs. 268515 meningioma (disrupted in balanced transl 5. 62 401183 NA 5. 62 426029 AW294138 Hs. 255277 ESTs 5. 61 443462 A1064690 Hs. 171176 ESTs 5. 61 447102 BE167434 Hs. 98471 ESTs, Weakly similar to T18712 hypotheb 5. 60 419150 T29618 Hs. 89640 TEK tyrosine kinase, endothelial (venous 5. 60 444577 Api207721 Hs. 11393 RAD51 (S. cerevisiae) homolog C 5. 60 423605 AF047826 Hs. 129887 cæhenn 19, type 2 5. 60 413447 AW969388 Hs. 10450 Homo sapiens cDNA : FLJ22063 fis, clone H 5. 60 442957 A1949952 Hs. 49397 ESTs 5. 60 424296 Api631874 Hs. 155140 casein kinase 2, alpha 1 polypeptide 5. 60 430679 R44428 Hs. 22801 ESTs 5. 60 449358 AA001229 Hs. 131436 ESTs 5. 60 418348 A1537167 Hs. 96322 hypothetical protein FU23560 5. 60 433133 AB027249 Hs. 104741 PDZ-binding kinase ; T-cell originated pr 5. 60 444059 R69743 Hs. 116774 integrin, alpha 1 5. 60 438157 AW137011 Hs. 49576 ESTs 5. 60 428233 A1358831 Hs. 20578 ESTs 5. 60 434265 AA846811 Hs. 130554 Homo sapiens cDNA : FU23089 fis, clone L 5. 60 451652 AA018968 Hs. 133536 ESTs 5. 59 422762 AL031320 Hs. 119976 HumanDNAsequenhromcloneRP1-20N20 5. 59 447591 A1675417 Hs. 282855 ESTs 5. 58 417958 AA767382 Hs. 193417 ESTs 5. 57 438146 Z36842 Hs. 57548 ESTs 5. 57 413595 AW235215 Hs. 16145 ESTs 5. 57 422406 AF025441 Hs. 116206 Opa-interacting protein 5 5. 56 420529 D25259 Hs. 319844 ESTs, Moderately similar to 154374 gene 5. 56 439582 W79161 Hs. 118327 Homo sapiens CDNA FU 11522 fis, clone HE 5. 56 408744 AW806177 gb : MR1-UM0108-130400-003dO4UM0108Homo 5. 56 447230 AW972147 Hs. 101395 hypothetical protein MGC11352 5. 54 428856 AA436735 Hs. 183171 hypothetical protein FU22002 5. 54 446813 AA971436 Hs. 16218 KIAA0903 protein 5. 53 451424 A1862026 Hs. 302810 Novel human gene mapping to chomosome 20 5. 53 410516 BE537917 Hs. 90034 hypothetical protein FLJ21916 5. 53 453994 BEl60964 Hs. 165590 hbosomat protein S13 5. 53 435583 AA767714 Hs. 291627 ESTs 5. 52 431585 BE242803 Hs. 262823 hypothetica protein FLJ10326 5. 51 408912 AB011084 Hs. 48924 KIAA0512 gene product ; ALEX2 5. 51 427966 R97130 Hs. 189699 ESTs 5. 51 433611 AW327692 Hs. 3446 mitogen-activated protein kinase kinase 5. 51 401244 NA 5. 50 410784 AW803201 gb : IL2-UM0077-070500-080-E06 UM0077 Homo 5. 50 434006 AF113688 gb : Homo sapiens clone FLB4630 5. 50 425650 Nom-001944 Hs. 1925 desmogtein 3 (pemphigus vutgaris antigen 5. 50 427507 AF240467 Hs. 179152 toll-like receptor 7 5. 50 423268 BE386898 Hs. 131162 ESTs, Weakly similar to ALU5_HUMAN ALU S 5. 50 405065 NA NA 5. 50 444302 A1140115 Hs. 225130 ESTs 5. 50 418183 NM 001772 Hs. 83731 CD33 antigen (gp67) 5. 50 435586 A1279137 Hs. 151498 ESTs 5. 50 438279 AA805166 Hs. 154762 HIV-1 rev binding protein 2 5. 50 427189 H82453 Hs. 5635 ESTs 5. 50 415263 AA948033 Hs. 130853 ESTs 5. 50 441818 Api630451 Hs. 7976 KIAA0332 protein 5. 50 407834 AW084991 Hs. 26100 ESTs 5. 50 404012 NA NA 5. 50 449932 A1675444 Hs. 263024 ESTs 5. 50 423760 AA775891 Hs. 191980 ESTs 5. 50 431576 M76665 Hs. 275215 hydroxysteroid (11-beta) dehydrogenase 1 5. 50 423172 R15652 gb : HH503-FAdu) t heart, aontech Homo sa 5. 50 422295 AF051151 Hs. 114408 toll-like receptor 5 5. 50 429044 A1261490 Hs. 145527 ESTs 5. 50 433280 AA581404 Hs. 289037 Homo sapiens cDNA FW 14135 fis, clone MA 5. 50 414323 NM_014759 Hs. 334688 KIAA0273 gene product 5. 50 405511 NA NA 5. 49 444665 BE613126 Hs. 47783 B aggressive lymphoma gene 5. 49 434434 AA633516 Hs. 157201 ESTs 5. 48 421997 R66740 Hs. 110613 KIAA0220 protein 5. 47 410276 A1554545 Hs. 68301 ESTs 5. 47 435867 AA954229 Hs. 114052 ESTs 5. 47 453837 AL138387 Hs. 256126 baculoviral IAP repeat-containing 7 (liv 5. 47 409617 BE003760 Hs. 55209 Homo sapiens mRNA ; cDNA DKFZp434K0514 (f 5. 47 430387 AW372884 Hs. 240770 nuclear cap binding protein subunit 2, 2 5. 47 401629 NA NA 5. 46 433071 BE150229 Hs. 281564 retina) outer segment membrane protein 1 5. 46 458247 R14439 Hs. 209194 ESTs 5. 46 418049 AA211467 Hs. 190488 Homo saoens, Similar to nuclear localiz 5. 45 418247 R55174 gb : yg87hO4. r1 Soares infant brain 1NiB H 5. 45 453716 AA037675 Hs. 152675 ESTs 5. 44 431157 A1823969 Hs. 132678 ESTs 5. 44 426873 Al190540 Hs. 131092 ESTs 5. 43 437092 AA744292 gb : ny51dO5. sl NCl_CGAP_Prl8 Homo sapiens 5. 42 445782 AW407672 Hs. 315367 Homo sapiens, Similar to hypothetical pr 5. 42

447393 A1377458 Hs. 158831 EST 5. 42 425283 AA354338 Hs. 131100 ESTs 5. 42 401208 NA NA 5. 42 430536 A1809163 Hs. 9908 nitrogen fixation cluster-like 5. 42 405523 NA 5. 42 409012 AL117435 Hs. 49725 DKFZP4341216 protein 5. 41 429803 W81489 Hs. 223025 RAB31, member RAS oncogene family 5 41 436982 AB018305 Hs. 5378 spondin 1, (f-spondin) extracellular mat 5. 40 422892 AA988176 Hs. 121553 hypothetical protein FU20641 5. 40 456027 BE327387 Hs. 13913 KA1577 protein 5. 40 411897 AW875066 Hs. 326876 Homo sapiens SOX6 mRNA, complete cds 5. 40 449689 AF228421 Hs. 23889 DKFZP564A032 protein 5. 40 432865 Al753709 Hs. 152484 ESTs, Weakly similar to 138022 hypotheb 5. 40 408248 AW854832 gb : QV2-CT0261-201099411-hOSCT0261 Homo 5. 40 418516 NM006218 Hs. 85701 phosphoinositide-3-kinae, catalytic, al 5. 40 423289 N77774 gb : yz83e01. r1 Soares multiple_sclerosis 5. 40 453365 AA035211 Hs. 17404 ESTs 5. 40 406465 NA 5. 40 441858 AW173339 Hs. 135665 ESTs 5. 40 432507 BE391093 Hs. 324667 ESTs 5. 40 440570 A1205712 Hs. 125998 ESTs 5. 40 445062 A1339915 Hs. 44324 ESTs 5. 40 421639 NM 012082 Hs. 106309 Friend of GATA2 5. 40 410406 A1969703 Hs. 1466 glycerol kinase 5. 40 418939 AW630803 Hs. 89497 lamin B1 5. 40 426010 AA136563 Hs. 1975 hypothetical protein FU21007 5. 40 400250 NA NA 5. 40 424650 AW576156 Hs. 250824 Homo sapiens cDNA : FLJ23435 fis, clone H 5. 40 414998 NM 002543 Hs. 77729 oxidisedlowdensitylipopntein (lectin 5. 39 433384 A1021992 Hs. 124244 ESTs 5. 38 428781 AF164799 Hs. 193384 putative 28 kDa protein 5. 38 438150 AA037534 Hs. 79059 transforming growth factor, beta recepto 5. 38 400639 NA 5. 38 426485 NM 006207 Hs. 170040 platelet-denved growth factor receptor-5. 37 424205 AA336825 gb : EST41732 Endometrial tumor Homo sapie 5. 36 459596 H29554 Hs. 113871 ESTs 5. 36 408234 AW993356 Hs. 285814 sprouty (Drosophila) homolog 4 5. 36 414547 T47770 Hs. 191463 ESTs 5. 35 419851 AA287987 Hs. 13477 ESTs, Weakly similar to 1207289A reverse 5. 35 411945 AL033527 Hs. 92137 v-myc avian myelocytomatosis viral oncog 5. 34 425764 AW996009 Hs. 112572 Homo sapiens cDNA FLJ 14130 fis, clone MA 5. 34 405352 NA 5. 33 448030 N30714 Hs. 325960 membrane-spanning 4-domains, subfamily A 5. 32 424284 BE541008 Hs. 6193 hypothetical protein FU14590 5. 32 427741 AW753185 Hs. 180628 dynamin 1-like 5. 31 426021 AW770897 Hs. 34392 ESTs, Weakly similar to l38022 hypotheú 5. 31 442186 AA984083 Hs. 269746 ESTs, Weakly similar to T03306 PSD-95/SA 5. 30 437319 BE410958 Hs. 56406 Homo sapiens cDNA FW 13549 hs, clone PL 5. 30 405287 NA NA 5. 30 427032 AF012023 Hs. 173274 integrincytoplamicdomain-asociatedp 530 415371 R15239 gb : yf89b02. r1 Soares infant brain 1 NIB H 5. 30 420024 AA252905 Hs. 194477 E3 ubiquitin ligase SMURF2 5. 30 434408 A1031771 Hs. 132586 ESTs 5. 30 434739 AA804487 Hs. 144130 ESTs 5. 30 421327 AA837295 Hs. 188802 ESTs 5. 30 453058 AW612293 Hs. 288684 Homo sapiens CDNA FU 11750 fis, clone HE 5. 30 448776 BE302464 Hs. 30057 MRS2 (S. cerevisiae)like, magnesium hom 5. 30 417845 AL117461 Hs. 82719 HomosapiensmRNA ; cDNADKFZp586F1822 (f 5. 30 430264 AA470519 gb : nc71fl O. sl NCl_CGAP_Prl Homo sapiens 5. 30 411402 BE297855 Hs. 69855 NRAS-related gene 5. 30 419220 AA811938 Hs. 291759 ESTs 5. 30 407995 A1094748 Hs. 100134 hypothetical protein FLJ12787 5. 30 459256 AW967468 Hs. 99821 hypothetical protein FLJ14547 5. 30 452449 AW068658 Hs. 20943 ESTs 5. 30 430366 A1057368 Hs. 105575 ESTs 5. 30 434360 AW015415 Hs. 127780 ESTs 5. 30 422560 F11469 Hs. 118281 zinc finger protein 266 5. 29 441704 A1458766 Hs. 201988 ESTs 5. 29 443635 A1080230 Hs. 134214 ESTs 5. 29 434342 A1791138 Hs. 116768 ESTs 5. 29 423409 NM_006466 Hs. 128207 polymerase (RNA) III (DNA directe* (39k 5. 29 449000 U69560 Hs. 3826 kelch-like protein C31P1 5. 29 452381 H23329 Hs. 290880 ESTs, Weakly similar to ALU1HUMANALUS 5. 29 409068 AW236991 Hs. 102495 ESTs, Moderately similar to 138022 hypot 5. 29 434860 AA932386 Hs. 292667 ESTs 5. 28 408096 BE250162 Hs. 83765 dihydrofolate reductase 5. 28 418036 Z37976 Hs. 83337 latent transforming growth factor beta b 5. 28 435443 A1248674 Hs. 14295 ESTs 5. 26 414269 AA298489 Hs. 303171 olfactory receptor, family 51, subfamily 5. 26 408371 AF161545 Hs. 279883 hypothetical protein 5. 26 401205 NA NA 5. 26 450904 R07118 Hs. 189924 ESTs 5. 26 416351 H49704 Hs. 173522 ESTs 5. 26

426524 AA380611 Hs. 163841 ESTs 5. 25 412901 AI127359 Hs. 289088 heatshock90kDproteinl, alpha 5. 25 452487 AW207659 Hs. 6630 Homo sapiens cDNA FLJ 13329 fis, clone OV 5. 24 444825 AW167613 Hs. 248 mitooen-activated protein kinae kinase 5. 24 412953 Z45794 Hs. 238809 ESTs 5. 24 404117 NA NA 5. 22 427956 AL046175 Hs. 108169 HomosapiensmRNA ; cDNA DKFZp586C1619 (f 5. 22 421787 AA227068 Hs. 108301 nuclear receptor subfamily 2, group C, m 5. 22 437255 R58970 Hs. 9887 ESTs 5. 22 424697 AL136169 Hs. 250708 CAAX box 1 5. 20 449771 A1668702 Hs. 54976 ESTs 5. 20 432193 AA372264 Hs. 273193 hypothetical protein FU10706 5. 20 438885 Al886558 Hs. 184987 ESTs 5. 20 407182 AA312551 Hs. 230157 ESTs 5. 20 452150 W42490 Hs. 260844 ESTs 5. 20 419680 AA249720 Hs. 59335 ESTs 5. 20 438940 AF075045 Hs. 271609 ESTs 5. 20 405362 NA NA 5. 20 449370 AK002114 Hs. 23495 hypothetical protein FU11252 5. 20 442353 BE379594 Hs. 49136 ESTs. Moderately similar to ALU7 HUMAN A 5. 20 409331 M36634 Hs. 53973 vasoactive intestinal peptide 5. 20 415397 H10818 gb : ym04f10. r1 Scares infant brain 1N ! 8H 5. 20 406735 AA603092 gb : np37aO1. sl NCl_CGAP_Lu1 Homosapiens 5. 20 418489 U76421 Hs. 85302 adenosine deaminase, RNA-specific, B1 (h 5. 20 431480 AA837274 Hs. 257005 hypothetical protein FU20837 5. 20 425523 AB007948 Hs. 158244 KIAA0479 protein 5. 20 425673 R70318 Hs. 339730 ESTs 5. 20 439267 AA287747 Hs. 173012 ESTs, Weakly similar to A46010 X-linked 5. 20 457030 Al301740 Hs. 173381 dihydropynmidinae-like 2 5. 20 424638 Api472106 Hs. 49303 Homo sapiens cDNA FLJ 11663 fis, clone HE 5. 20 454434 AA083558 Hs. 261286 ESTs 5. 20 448336 R53848 Hs. 44976 ESTs 5. 20 429534 AW976987 Hs. 163327 ESTs. Weakly similar to 2109260A B cell 5. 20 434803 AW974640 Hs. 303413 ESTs 5. 20 403199 NA NA 5. 20 435225 A1021912 Hs. 187983 ESTs 5. 20 451664 AA889081 Hs. 153952 6 nucleofidase (CD73) 5. 20 440385 AA884283 Hs. 192136 ESTs 5. 20 432328 Api572739 Hs. 195471 6-phosphofructo-2-kinaselfructose-2, 6-bi 5. 20 400484 NA 5. 20 425757 AA363171 gb : EST72986 Ovary II Homo sapiens cDNA 5 5. 19 449841 A1671602 Hs. 199602 ESTs 5. 19 420303 AA258282 Hs. 278436 KIAA1474 protein 5. 19 429687 At675749 Hs. 211608 nucleoporin 153kO 5. 19 453345 AA302862 Hs. 90063 neurocalcin delta 5. 18 447499 AW262580 Hs. 147674 protocæhenn beta 16 5. 18 404913 NA 5. 18 405114 NA NA 5. 18 431117 AF003522 Hs. 250500 delta (Drosophila)-likel 5. 18 411995 W49701 Hs. 29667 ESTs 5. 17 401736 NA NA 5. 17 425250 AA353495 Hs. 269762 ESTs, Weakly similar to A47582 B-cell gr 5. 16 454388 AA630905 Hs. 333300 hypothetical protein FLJ14026 5. 16 449032 AA045573 Hs. 22900 nuclear factor (erythroid-derived 2)-lik 5. 16 443646 A1085198 Hs. 164226 ESTs 5. 15 436032 AA150797 Hs. 109276 latexin protein 5. 15 456896 M97639 Hs. 155585 receptor tyrosine kinase-like orphan rec 5. 15 433672 BE281165 Hs. 288038 TLS-associated serine-arginine protein 1 5. 15 432826 X75363 Hs. 250770 ACO for senne protease homologue 5. 14 439441 W67993 Hs. 323135 ESTs 5. 14 400205 NA NA 5. 14 430854 AW440369 Hs. 47026 ESTs 5. 14 408771 AW732573 Hs. 47584 potassium voltage-gated channel, delayed 5. 14 456804 Api421645 Hs. 139851 caveolin 2 5. 14 424690 BE538356 Hs. 151777 eukaryotictranslationiniSaúonfætor 5. 13 449210 A1635363 Hs. 197636 ESTs 5. 12 419013 T90378 Hs. 14463 ESTs 5. 12 425843 BE313280 Hs. 159627 death associated protein 3 5. 12 422545 X02761 Hs. 287820 fibronectin 1 5. 12 424785 R23519 Hs. 6126 hypothetical protein dJ1141E15. 2 5. 11 442833 AA328153 Hs. 88201 ESTs, Weakly similar to A Chain A, Cryst 5. 10 422411 AW749443 Hs. 22511 ESTs 5. 10 457565 BE294029 Hs. 279903 Ras homolog enriched in brain 2 5. 10 437722 AW292947 Hs. 122872 ESTs, Weakly similar to JU0033 hypotheti 5. 10 446893 At610818 Hs. 7110 ESTs S. tO 401581 NA 5. 10 417511 AL049176 Hs. 82223 chordin-like 5. 10 422336 Api761322 Hs. 115285 dihydrolipoamide S-acetyltransferase (E2 5. 10 437662 AA765387 Hs. 145095 ESTs 5. 10 429526 AA454182 Hs. 99360 ESTs 5. 10 447332 AW445012 Hs. 160918 ESTs 5. 10 436207 AA334774 Hs. 12845 hypothetical protein MGC13159 5. 10 428155 H17012 Hs. 14633 ESTs 5. 10

420185 AL044056 Hs. 158047 ESTs 5. 10 445657 AW612141 Hs. 279575 Homo sapiens G-protein coupled receptor 5. 10 440913 A1267491 Hs. 160593 ESTs 5. 10 452943 BE247449 Hs. 31082 hypothetical protein FLJ10525 5. 10 428603 BE241619 Hs. 24641 cytoskeleton associated protein 2 5. 10 436577 W84774 Hs. 17643 ESTs 5. 10 400241 NA NA 5. 10 437205 AL110232 Hs. 279243 HomosapiensmRNA ; cDNADKFZpS64D2071 ( 5. 10 423654 Api674253 Hs. 35828 ESTs 5. 10 417637 AA204969 Hs. 234863 Homo sapiens cDNA FW 12082 hs, cione HE 5. 10 430849 Al940727 Hs. 270556 ESTs, HighlysimilartoAF1567791ASB-4 5, 10 452605 AW968557 Hs. 90012 hypothetical protein FLJ23441 5. 10 440381 AA917808 Hs. 190495 ESTs 5. 10 441033 BE562555 gb : 601335867F1 NIH MGC 44 Homo sapiens c 5. 10 450229 R18717 Hs. 8929 hypotheticalprotein FLJ11362 5. 10 447197 R36075 gb : yh88bO1. sl Soares placenta Nb2HP Homo 5. 10 442150 A1368158 Hs. 70983 PTPL1-associated RhoGAP 1 5. 10 415651 AI207162 Hs. 3815 stathmin-like-protein RB3 5. 10 453655 AW960427 Hs. 79059 transforming growth factor, beta recepto 5. 09 434442 AA737415 Hs. 152826 ESTs 5. 09 429389 AA454779 Hs. 201441 Homo sapiens DNA 11079fis. done PL 5. 09 435419 A1281068 Hs. 152835 ESTs 5. 09 427620 NM_003705 Hs. 179866 soiute carrier family 25 (mitochondriai 5. 09 445706 AA305520 Hs. 108812 hypothetical protein FU22004 5. 08 424071 R71340 Hs. 12876 ESTs 5. 08 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 5. 08 426400 M78361 Hs. 169743 Homo sapiens clone 25121 neuronal oltact 5. 08 429026 AA443385 Hs. 221993 ESTs 5. 08 455847 BE146775 gb : QV4-HT0222-181099-013-e04 HT0222 Homo 5. 08 416110 Z42262 Hs. 322844 hypotheticalprotein DKFZp564A176 5. 08 436854 AA749167 Hs. 173911 ESTs 5. 08 421799 AW972292 Hs. 292998 ESTs 5. 08 452154 AW953265 Hs. 302746 MSTP028 protein 5. 06 444946 AW139205 Hs. 156457 hypothetical protein FLJ22408 5. 06 445950 A1267957 Hs. 145706 ESTs 5. 06 443124 A1033500 Hs. 132895 ESTs 5. 06 440698 Al348455 Hs. 147492 Homo sapiens cDNA FLJ 11777 fis, clone HE 5. 06 444713 AW812074 Hs. 28631 HomosapienscDNA : FLJ22141 fis, clone H 5. 06 447970 AW086109 Hs. 20136 chromosome X open reading frame 6 5. 06 419307 AW953190 Hs. 23180 ESTs 5. 06 421954 AA410245 Hs. 40323 BUB3 (budding uninhibited by benzimidazo 5. 06 451807 W52854 Hs. 27099 hypothetical protein FU23293 similar to 5. 05 421782 AB029290 Hs. 108258 actin binding protein ; macrophin (microf 5. 05 407976 A1633875 Hs. 77823 hypothetical protein FU21343 5. 05 400869 NA 5. 04 416153 R13894 gb : yf62aO6. rlSoaresinfantbrain1NIBH 5. 04 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 5. 04 406038 Y14443 Hs. 88219 zinc finger protein 200 5. 03 440659 AF134160 Hs. 7327 claudin 1 5. 03 425188 AK002052 Hs. 155071 hypothetical protein FLJ11190 5. 02 446051 BE048061 Hs. 37054 ephrin-A3 5. 02 443387 BE139135 Hs. 254629 ESTs 5. 02 414407 AA147026 Hs. 76704 ESTs 5. 02 408349 BE546947 Hs. 44276 homeo box C10 5. 01 452510 Z33566 Hs. 301491 ESTs 5. 01 447245 AK001713 Hs. 17860 hypotheticalprotein FLJ10851 5. 00 413472 BE242870 Hs. 75379 solute carder family I (glial high affi 5. 00 447857 AA081218 Hs. 58608 Homo sapiens cDNA FW14206 fis, clone NT 5. 00 423648 AK000456 Hs. 130546 hypotheticalprotein FLJ20449 5. 00 412997 BE046600 gb : hn41dOB. xl NCl CGAP_RDF2Homosapiens 5. 00 408964 AF201468 Hs. 49349 beta-site APP-cleaving enzyme 5. 00 411636 AW855001 gb : PM3-CT0263491239407-hOSCT0263Homo 5. 00 418111 R42003 Hs. 106513 ESTs 5. 00 402709 NA NA 5. 00 408677 Api279892 Hs. 46801 sorting nexin 14 5. 00 411350 AW877011 gb : QV2-PT0010-250300-096bO5 PT0010Homo 5. 00 453382 AA709285 Hs. 5997 hypotheticat protein FU 13078 5. 00 458090 A1282149 Hs. 56213 ESTs, Highly similar to FXD3_HUMAN FORKH 5. 00 408512 AW902013 Hs. 255937 ESTs 5. 00 453240 A1969564 Hs. 166254 hypothetical protein DKFZp5661133 5. 00 440491 R35252 Hs. 24944 ESTs, Weakly similar to 2109260A B cell 5. 00 423896 AA332216 Hs. 130584 ESTs 5. 00 429091 AA935658 Hs. 187939 ESTs 5. 00 410968 AA199907 Hs. 67397 homeoboxA1 5. 00 436859 AA732681 Hs. 270053 ESTs 5. 00 452198 A1097560 Hs. 61210 ESTs, Weakly similar to 138022 hypotheti 5. 00 424511 BE300512 Hs. 193557 ESTs, Moderately similar to AlU7 HUMAN A 5. 00 414631 AW970130 Hs. 65406 ESTs 5. 00 405481 NA 5. 00 431118 BE264901 Hs. 250502 carbonicanhydraseVIII 500 421373 M808229 Hs. 167771 ESTs 5. 00 424916 AW867440 Hs. 23096 ESTs 5. 00 433106 AB002443 Hs. 184418 ESTs 5. 00

427386 AW836261 Hs. 337717 ESTs 5. 00 441998 Al733236 Hs. 128312 ESTs, Weakly similar to ALU1 HUMAN ALU S 5. 00 420161 A1683069 Hs. 175319 ESTs 5. 00 430899 BE018217 Hs. 183528 hypothetical protein FU 14906 5. 00 415188 BE007531 Hs. 258791 ESTs 5. 00 420429 AW293291 Hs. 255180 ESTs 5. 00 439038 AV655045 Hs. 8366 ESTs 5. 00 457031 A1497955 Hs. 304802 ESTs, Weakly similar to KIAA0944 protein 5. 00 430865 A1073424 Hs. 5232 HSPC125 protein 5. 00 420583 H77859 Hs. 65450 reGculon 4 5. 00 432229 AW290976 Hs. 143587 ESTs 5. 00 455208 BE180276 gb : RC3-HT0622-130400-022-a02HT0622Homo 5. 00 419263 AW583874 Hs. 89832 insulin 5. 00 452279 AA286844 Hs. 61260 hypothetical protein FU13164 5. 00 419100 AA464362 Hs. 6748 hypothetical protein PP1665 5. 00 438585 AA811371 Hs. 123362 ESTs 5. 00 436953 AW959074 Hs. 23648 Homo sapiens cDNA FW13097 fis, clone NT 5. 00 428775 AA434579 Hs. 143691 ESTs 5. 00 422471 AA311027 Hs. 271894 ESTs. Weakly similar to 138022 hypotheti 5. 00 402524 NA 5. 00 TABLE 46B : Pkey : Unique Eos probeset identifier number CAT number. Gene cluster number Accession : Genbank accession numbers Pkey CAT number Accessions 408248 1049240 1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 408432 10586671 AWi95262R27868AW811262 408744 10783091 AW806177AW806178AW265775 409948 116139 t AA078643 BE535933 AA132607 410424 120166 1 M084964Z18302AW502279AW499519 410444 1203699 1 W73484 AW748569 AW748532 AW748585 410498 120611 1 AA355749 AA085520 AW966333 AA340319 BE170936 410784 1221005 1 AW803201 BE079700 BE062940 410979 1228509 1 BE151480D63282AW812615 411253 1236671_1 AW833897 AW833907 AW833908 AW833920 AW833953 AW833881 AW833878 AW833879 AW833952AW833919 AW833921 AW833915 411350 1239976 1 AW877011 AW877066 AW877136 AW876980 AW991827 AW877073AW877070AW882665 AW876972 AW877068 AW877064 AW838297 AW877065 AW876974 AW877101 AW877067 AW877127 AW876975 AW876979 AW876983 AW877131 AW877104 411636 1252525_1 AW855001 AW855031 BE062221 411861 1261785_1 AW867875 BE067343 BE067301 BE067350 BE067305 BE067347 BE067306 BE067304 BE067303 BE067302 AW938147 412227 1284297 1 AW902282 AW902508 AW902509 AW902605 AW902606 AW902643 AW902490 412345 1289783 1 AW938386 AW938411 AW938426 AW938397 412396 1292796 1 AW947895 AW947891 AW947933 AW947892 AW947930 AW947889 AW947894 AW947931 AW947893 AW947932 AW947929 412997 13432051 BE046600BE046677BE046236 413604 1379715_1 R51767 BE152515 Z44834 H23397 413894 1397740 1 BE177983 BE178322 414727 1481204 1 BE466904W28721 415308 1533673 1 F05251 R13748 Z44028 H14747 415371 1535066 1 R15239 Z45189 F06836 415397 1535937 1 H10818F07831 Z43072 415637 1540904_1 R25517 F13222 T75465 416153 1573947 1 R13894 H23037 R56371 416190 1576789 1 N54000H26494T83818 416845 1624038_1 H95279 H95331 H95933 416913 163001 1 AW934714 BE161007 BE162500 AW749902 AW749864 8E162498 BE161005 AA190449 AW513465 BE161006 BEt62499 417352 166908 1 AA195919 D79180 BE543135 BE008355 BE008353 BE008315 BE008317 417588 1688092_1 Z44510R24958R00714T82024 418247 1733290_1 R55174Z19829X97508 418553 1767393 1 T88964R99447T84773 418647 177521 1 AA226198 AA226513 AA383773 418866 179788 1 T65754 AA229857 AA229658 423172 225618_1 R15652M322742 AW961639 AW961637 423289 226804 1 N77774 AA324125 AW955199 AA452230 423395 227885-1 AA326613 AA325417 AW962164 423928 233416 1 AA332680 AA332831 AW962684 424205 236651 1 AA336825 AA337256 AA337682 AA337525 425757 255956 1 AA363171 AW963347 AA371863 428679 294049 1 AA431765 AA432015 430264 315008 1 AA470519 BE303010 BE302954 BE384120 430818 324239 1 AI311928 AA936030 T51931 AA609816 AA487195 AA664207 432494 348522 1 AA551060 AW979274 AA847429 AA878487 432639 351744 1 AW973785 H60163 AA557608 433009 3573711 AA761668AA573621R92814R09670 434006 37855_1 AF113688AI114617 434603 38944_1 AF147384 T60126 T60244 436411 419334_1 AW674352 AA715374 Z25205 437092 432938 1 AA744292 AA745577 AW748517 AW748564 AW748511 AW748513 AW748530 AW748574 BE062923 437237 43506-2 BE513073 441033 50807_-1 BE562555 441761 525307 1 A1222880 A1242392 AA961560 A1242524 A1719648 A1718138 AW275807 442075 532052_1 AW136928 A1685655 BE218584 BE465078 N68963 AA975338 BE147199 N76377

445165 63181 1 AV652831 AA191140 AA329706 AI267893 AI796986 AW675672 AW t95369 BE002835 BE003284 AA190592 AA769594 AW275548 R56781 AA807313 AW169695 N31806 447197 711623 1 R36075 A1366546 R36167 453685 977734 1 AL110309AW088119H22881 454511 1220533 1 AW948146 AW948135 AW802578 454758 1233743_1 AW845266 AW845254 AW819440 AW819430 AW819425 AW819423 454835 1236507 AW833763AW833704AW833618 455082 1252687_1 BE148180AW855210AW855243 455208 1260551_1 BE180276AW866156BE180165 455212 1260678_1 AW866330 AW866410AW866332 AW866411 AW866327 AW866326AW866335AW866334 AW666331 AW666333 AW866328 AW866329 455217 12615221 AW867534AW867539 455608 1337389 1 BE011437 BE011402 BE011395 BE011428 BE011407 BE011421 BE011406 455847 1375358 1 BE146775 BE146789 BE146792 BE147010 BE146941 BE146801 BE146998 BE147011 BE146903 BE146901 455944 1385569_1 BE160643 BE160585 457892 432926. 1 AA744389AA744270AA744284AA744299AA745380AA744337AA846905AA84 7698 457893 432938 1 AA744292 AA745577 AW748517 AW748564 AW748511 AW748513 AW748530 AW748574 BE062923 459279 975649_1 AW814996 AL047199 AW850979 TABLE 46C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 400484 8569067 Minus 52725-52912 400570 9884797 Minus 156787-156862, 178082-178208, 18681g186957 400639 9887597 Plus 23150-23580 400845 9188605 Plus 34428-34612 400860 9757499 Minus 151830-152104, 152649-152744 400869 9838306 Plus 29152-30102 400950 7658481 Minus 157920-158564 400977 8072510 Plus 73950-74364 401004 7229982 Plus 62580-62772 401093 8516137 Minus 22335-23166 401183 7670214 Minus 39921-40601 401205 9743388 Plus 167373-167433, 167936-168031 401208 7712287 Plus 163145-163281 401244 4827300 Minus 55359-56376 401348 9930791 Minus 93659490 401372 9944181 Plus 127056-127196 401424 8176894 Plus 24223-24428 401581 9502454 Plus 9440-10165 401629 8575965 Minus 169336-169788 401708 2951946 Pius 154511-155298 401736 3219338 Plus 1771-1894 401740 2982169 Plus 148357-148484, 148591-148690 401747 9789672 Minus I I B596-118816, 119110-119244. 119600-119761, 120422-120990, 130161-130381, 13046B-1 30593, 131097-131258, 131866- 131932, 132451-132575, 133580-134011 401961 4581193 Minus 124054-124209 402343 8099256 Plus 4677-6084 402363 9454515 Plus 25693-25991 402408 9796239 Minus 110326-110491 402524 9798518 Minus 20529-21096 402709 8901246 Minus 56847-57055 402732 9211639 Minus 147904-148107 403040 3133144 Minus 91632-91788, 9791&98115 403137 9211494 Minus 92349-92572, 92958-93084, 93579-93712, 93949-94072, 94591-94748, 95214-95337 403199 9958183 Minus 588959036, 66618-66789 403278 8072597 Plus 146823-146986 403546 8078400 Plus 94703-94849 403764 7717105 Minus 118692-118853 403776 7770611 Minus 1414-1513, 1624-1756 403859 7708954 Plus 113738-113858 403973 8575876 Plus 93873-94384 404012 8655948 Plus 551356-552233 404029 7671252 Plus 108716-111112 404072 9931705 Plus 49546-50498 404117 9796029 Plus 149723-149920 404170 9930793 Plus 168836-169248 404335 9838027 Minus 21030-21145, 26504-26692 404440 7528051 Plus 80430-81581 404632 9796668 Plus 45096-45229 404702 7630798 Plus 78043-78890 404913 7341740 Plus 97717-97976 404996 6007890 Plus 379938145, 38652-38998, 39727-39872, 40557-40674, 42351-42450 405033 7107731 Minus 142358-142546 405065 7684500 Minus 13855-14027 405114 8096938 Minus 97013-97560 405287 3928029 Plus 89802-89999 405352 2822162 Minus 97253-97742 405362 2337862 Minus 105008-105142, 105980-106091, 140445-140556, 142519-142641

405481 3688109 Plus 5718-5837, 8719-8818 405511 9454623 Plus 57731-57852 405523 9454643 Plus 114550-114688, 117265117407, 119490-119599, 123237-123395, 13114131217 405543 9857582 Minus 104338-104449 405545 1054740 Plus 118677-118807, 119091-119296, 121626-1218 23 405637 6289229 Plus 189852-189978 405696 4309923 Minus 1865-2013. 2124-2231 405770 2735037 Plus 61057-62075 406465 9795550 Plus 94502-94706, 96776-96914, 9879r98928, 102423-102576, 105087-105191, 107023-107127, 108852-108992 TABLE 47A : ABOUT 370 GENES SIGNIFICANTLY DOWN-REGULATED IN STOMACH CANCER COMPARED TO NORMAL STOMACH Table 47A lists about 370 genes significant down-regulated in stomach cancer compared to normal stomach. These were selected as for Table 46A, except that the numerator and denominator were switched and the ratio was equal to or less than 0. 33. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : Ratio of tumor to normal body tissue Pkey ExAccn UnigenelD Unigene Title R1 412859 NM000705 Hs. 813 ATPase, HI/Klexchanging, betapolypepti 0. 02 423371 AU076819 Hs. 1650 solutecanierfamily26, member3 0. 02 425607 U09860 Hs. 158333 protease, serine, 7 (enterokinase) 0. 04 429050 X81333 Hs. 194777 mepnn A, beta 0. 04 421996 AW583807 Hs. 1460 glucagon 0. 05 441212 AW242447 Hs. 146182 cytosolic betaglucosidase 0. 05 429093 NM 000253 Hs. 195799 microsomattrigiycende transfer protein 0. 06 403697 NA NA 0. 07 402760 NA NA 0. 08 428285 AW340797 Hs. 98434 ESTs 0. 08 419279 AA235900 Hs. 87500 ESTs 0. 08 422459 K02100 Hs. 117050 omithine carbamoyltransferase 0. 09 422992 AF016833 Hs. 122785 maltase-glucoamylase (atpha-glucosidase) 0. 09 430867 M16404 Hs. 248099 cholinergic receptor, muscannic 2 0. 09 453989 M63962 Hs. 36992 ATPase, H*lK+exchanging, alphapolypepl 0. 10 443022 AL046485 Hs. 207604 ESTs 0. 10 413382 BE090689 gb : RC1-BT0720-280300-011-f08BT0720Homo 0. 10 450769 AA057418 Hs. 33654 ESTs 0. 10 428070 T63918 Hs. 182313 retinol-binding protein 2, cellular 0. 10 415447 Z97171 Hs. 78454 myocilin, trabecular meshwork inducible 0. 11 430073 U86136 Hs. 232070 telomerase-associated protein 1 0. 11 431716 D89053 Hs. 268012 fatty-acid-Coenzyme A ligase, long-chain 0. 12 416889 AW250318 Hs. 80395 mal, T-cell differentiation protein 0. 12 405650 NA NA 0. 12 419219 AW583139 Hs. 89717 carboxypeptidaseA2 (pancreatic) 0. 12 401623 NA NA 0. 12 400811 AF219139 Hs. 87726 KIAA0154 protein ; ADP-ribosylation facto 0. 13 455826 BE144228 gb : MRO-HT0165-140200-009-d04HT0165Homo 0. 13 414949 C15314 Hs. 323349 ESTs 0. 13 407486 S69741 gb : hSCG-3=stomæhcanrgene-3 (oncogen 0. 13 407494 U10072 gb : Human forkhead family (AFX1) mRNA, pa 0. 13 401015 NA NA 0. 13 426651 AU076646 Hs. 171683 nuclear receptor subfamily 1, group H, m 0. 14 450926 AI744361 Hs. 205591 ESTs, Weakly similar to T46608 zinc fing 0. 14 443564 A1921685 Hs. 199713 ESTs 0. 14 457955 A1208986 Hs. 143945 ESTs 0. 14 457345 A1699933 Hs. 192175 ESTs 0. 14 417118 U38654 Hs. 50477 RAB27A, member RAS oncogene family 0. 14 408518 BE162203 Hs. 314758 ESTs 0. 14 444938 AW470690 Hs. 148814 ESTs 0. 15 403670 NA NA 0. 15 432440 X63597 Hs. 2996 sucrase-isomaltase 0. 15 428492 AW662740 Hs. 259391 ESTs 0. 15 443607 A1452512 Hs. 134069 ESTs 0. 15 446914 BE044496 Hs. 166994 FAT tumor suppressor (Drosophila) homolo 0. 15 424596 AB020639 Hs. 151017 estrogen-related receptorgamma 0. 15 430350 BE169639 gb : PM1-HT0527-280200-005-a05HT0527Homo 0. 16 431094 AW972276 Hs. 116195 ESTs 0. 16 401683 NA NA 0. 16 419278 AU076799 Hs. 1247 apolipoprotein A-IV 0. 16 455071 BE145826 gb : MRO-HT0208-1 01299-202 e 12 HT0208 Homo 0. 16 454282 AW296422 gb : UI-H-BWO-aio-h-054Ul. s1 NCI CGAP_Su 0. 16 428848 NM 000230 Hs. 194236 leptin (munneobesibhomolog} 0. 16 451729 AW160725 Hs. 312469 ESTs 0. 16 451103 R52804 Hs. 25956 DKFZP564D206 protein 0. 16 428602 AL137479 Hs. 186655 Homo sapiens mRNA ; cDNA DKFZp434M0223 (f 0. 16 437157 BE048860 Hs. 120655 ESTs 0. 17 422731 AL138411 gb : DKFZp434Al229-ri 434 (synonym : htes3) 0. 17 402015 NA NA 0. 17 414758 H82022 Hs. 282847 pregnancyspeciEcbeta-1-glycoprotein3 0, 17 412793 AW997986 gb : RC1-8N0056-230200-021-e11BN0056Homo 0. 17 438152 AW292520 Hs. 122082 ESTs 0. 17

401685 NA NA 0. 17 441519 AA972740 Hs. 127092 ESTs 0. 17 438327 H87407 Hs. 172944 chorionisgonadotnopin, betapolypeptide 0. 17 402761 BE387621 Hs. 108809 chaperonin containing TCPt, subunit 7 (e 0. 17 424268 AA397653 Hs. 307438 Human DNA sequence from clone 495010 on 0. 18 414507 AW102637 Hs. 13349 Homo sapiens cDNA FLJ14647 fis, clone NT 0. 18 413808 J00287 Hs. 182183 HomosapiensmRNAforcaldesmon, 3 UTR 0. 18 401132 NA NA 0. 18 412374 X01388 Hs. 73849 apolipoproteinC-III û. 18 423417 AP000365 Hs. 128342 potassiumlangeconductancecalcium-æti 0. 18 447677 At419235 gb : ff21dO2. xi NCl_CGAP_Brn23 Homo sapien 0. 18 448828 A1580296 Hs. 174782 ESTs, Weakly similar to KIAA1447 protein 0. 18 424122 AA335593 Hs. 116147 ESTs 0. 18 417332 AW972717 Hs. 288462 hypothetical protein FU21511 0. 18 434597 AW974668 gb : EST386757 MAGE resequences, MAGM Homo 0. 19 428804 AK000713 Hs. 193736 hypothetical protein FU20706 0. 19 410280 AA083558 Hs. 261286 ESTs 0. 19 409382 AA071244 gb : zm73gO3. ri Stratagene neuroepithelium 0. 19 428062 AA420683 Hs. 98321 hypothetical protein FU14103 0. 19 426069 H10807 Hs. 281434 HomosapienscDNAFW14028hs, cloneHE 0. 19 430135 NM 000035 Hs. 234234 aidotaseB. fructose-bisphosphate 0. 19 414802 A1793107 Hs. 27018 Ris 0. 19 457432 NM 005136 Hs. 268538 potassium voltage gated channel, Isk-rel 0. 19 446909 AA004895 Hs. 30082 ESTs 0. 19 435447 A1872932 gb : wm72eO3. xl NCI CGAP_Ut2 Homo sapiens 0. 20 408611 NM004367 Hs. 46468 chemokine (C-C motif) receptor 6 0. 20 423577 AW810107 Hs. 58633 Homo sapiens cDNA : FLJ22145 fis, clone H 0. 20 439328 W07411 Hs. 118212 ESTs, ModeratelysimilartoALU3_HUMANA 0. 20 436741 AA860163 Hs. 291319 ESTs 0. 20 426635 BE395109 Hs. 129327 hypothetical protein MGC13057 0. 20 418277 AW135221 Hs. 130812 ESTs 0. 20 448871 BE616709 Hs. 159265 kruppel-related zinc finger protein hckr 0. 20 459370 AA889982 Hs. 271826 ESTs Weaklysimilarto 138022hypotheti 0. 21 427469 AA403084 Hs. 269347 ESTs. Weakiy similar to 2109260A B cell 0. 21 432887 Al926047 Hs. 162859 ESTs 0. 21 421296 Nom002666 Hs. 103253 perilipin 0. 21 449216 AW295417 Hs. 224616 ESTs 0. 21 414835 AA156720 Hs. 185342 ESTs 0. 21 459233 A1939966 gb : MRO-CT0015-160799-W2-bO6 CT0015 Homo 0 21 439756 AL359651 Hs. 283852 Homo sapiens mRNA full length insert cDN 0. 21 427167 A1239607 Hs. 99196 hypothetical protein MGC11324 0. 21 400410 AF154915 Hs. 283958 homeo box D12 0. 21 409828 AW501137 gb : UI-HF-BPOp-aito12-0-Ul. rl NIH MGC 5 0. 22 428470 AC002301 Hs. 184507 Homo sapiens Chromosome 16 BAC clone CIT 0. 22 455968 BE168828 gb : QV1-HT0517-020400-145-hNiHT0517Homo 022 404145 NA NA 0. 22 454011 M31008 Hs. 37009 alkaline phosphatase, intes6nal 0. 22 430588 A1741461 Hs. 161904 ESTs 0. 22 403652 NA NA 0. 22 440410 AW204436 Hs. 128715 ESTs 0. 22 453871 BE300380 Hs. 69476 Homo sapiens cDNA FLJ 12758 fis, clone NT 0. 22 458567 A1222075 Hs. 147831 ESTs 0. 22 436004 AA703332 Hs. 196270 folate transporter/carier 0. 22 417408 F17211 Hs. 86092 Homo sapiens skeletal myosin light chain 0. 22 448643 A1557531 gb : pt2. 1-06. D06. r tumor2 Homo sapiens cD 0. 22 404401 NA NA 0. 22 428088 AA421130 Hs. 112640 EST 0. 22 427074 AA527435 Hs. 178589 hepalocellular carcinoma antigen gene 52 0. 22 421972 M18185 Hs. 1454 gastric inhibitory polypeptide 0. 22 429001 AF098951 Hs. 194720 ATP-binding cassette. sub-family G (WHIT 0. 22 441155 AW161008 Hs. 7719 GABA (A) receptor-associated protein 0. 22 402750 NA NA 0. 22 438587 AA811450 Hs. 136984 ESTs 0. 22 404848 NA NA 0. 22 427833 AA416615 Hs. 98242 ESTs 0. 23 439907 AA853978 Hs. 124577 ESTs 0. 23 414373 AW162907 Hs. 75969 proline-rich protein with nuclear target 0. 23 446817 A1700684 Hs. 134166 ESTs 0. 23 437333 AA748898 gb : ny76h10. s1 CGAPGCB1 Homo sapiens 0. 23 404097 NA NA 0. 23 446393 AW014174 Hs. 301956 zinc finger protein 0. 23 456328 T41368 gb : phidl 1911N Outward Alu-primed hncDN 0. 23 401042 NA NA 0. 23 458441 AW842283 Hs. 79933 cyclin I 0 23 435547 AW117431 Hs. 191906 ESTs 0. 23 429060 AW139155 Hs. 194995 hypothetical protein DKFZp43400320 0. 23 425158 AW954631 Hs. 266940 t-complex-associated-testis-expressed 1-0. 23 448758 AB018311 Hs. 21917 KIAA0768 protein 0. 23 441240 AA923749 Hs. 132442 ESTs 0. 23 436562 H71937 Hs. 322904 ESTs, Weakly similar to 138022 hypotheti 0. 23 424104 AA669515 Hs. 144950 ESTs 0. 23 447452 BE618258 Hs. 102480 Homo sapiens, clone ! MAGE : 3869590, mRNA, 0. 23 444515 AW204908 Hs. 169979 ESTs 0. 24

433084 M18079 Hs. 282265 fatty acid binding protein 2, intestinal 0. 24 406560 NA NA 0. 24 432408 N39127 Hs. 332557 ESTs, Weakly similar to A46010 X-linked 0. 24 455699 BE068121 gb : CM1-BT0368-061299-060-aO2 BT0368 Homo 0. 24 453979 M68895 Hs. 76800 alcohol dehydrogenase 6 (class ) 0. 24 439657 W93589 gb : zd95gO5. s1 Soares_fetal_heart_NbHH19W 0. 24 407512 X15674 gb : Human pTR5 mRNA for repetitive sequen 0. 24 440875 AW138036 Hs. 201788 ESTs 0. 24 404753 NA NA 0. 24 411119 M60627 Hs. 753 formyl peptide receptor 1 0. 24 418692 AK000268 Hs. 87383 hypothetical protein 0. 24 415327 H22769 gb : ym54c02. rt Soares infant brain lNIB H 0. 24 429446 AI547111 gb : PN2. 1 A01 G12. rmynommHomosapiensc 0. 24 455391 BE156230 gb : CiVOHT0367-310100-102-cil HT0367Homo 0. 25 422818 AA404290 Hs. 97848 ESTs 0. 25 435338 AA678071 Hs. 194300 ESTs, Weakly similar to 138022 hypotheti 0. 25 414203 BE262170 Hs. 78629 ATPase, Na+JKo transporting, beta 1 poly 0. 25 403941 NA NA 0. 25 414383 BE279406 gb : 601157981F1 NIH MGC_21 Homosapiensc 0. 25 412008 Nom-001841 Hs. 73037 cannabinoid receptor 2 (macrophage) 0. 25 424985 A1907236 Hs. 279935 Homo sapiens DNA 11780 fis. done HE 0. 25 450736 AW970060 gb : EST382140 MAGE resequences, MAGK Homo 0. 25 431185 H02767 Hs. 28944 ESTs 0. 25 455308 AW893949 gb : RC4-NN0027-060400-011-a09NN0027Homo 0. 25 435464 BE548300 Hs. 192999 ESTs, Moderately similar to KIAA0961 pro 0. 25 418525 AW450369 Hs. 86937 ESTs 0. 25 402790 NA 0. 25 411869 W20027 Hs. 23439 ESTs 0. 25 400332 S66407 Hs. 248032 FLT4 0. 25 424884 AW299437 Hs. 225717 ESTs 0. 25 414376 BE393856 Hs. 66915 ESTs, Weakly similar to 16. 7Kd protein 0. 25 439780 AL109688 gb : Homo sapiens mRNA full length insert 0. 25 408947 AL080093 Hs. 49117 HomosapiensmRNA ; cDNA DKFZp564N1662 (f 0. 25 404900 NA NA 0. 25 441918 A1733373 Hs. 128119 ESTs 0. 25 441639 A1133287 Hs. 303953 ESTs 0. 25 459396 A1907536 Hs. 103869 ESTs 0. 25 452755 AW138937 Hs. 213436 ESTs, Weakly similar to A34087 hypotheb 0. 25 422183 AA431698 Hs. 112794 Human DNA sequence from clone 1068E13 on 0. 25 415186 AA160945 Hs. 14479 Homo sapiens cDNA FLJ 14199 fis, clone NT 0. 26 429450 AA824451 Hs. 94292 hypothetical protein FU23311 0. 26 455615 BE045344 Hs. 274923 ESTs, Moderately similar to unnamed prot 0. 26 454633 AW811380 gb : lL3-ST0143-290999-019-D05 ST0143 Homo 0. 26 424853 BE549737 Hs. 132967 Human EST clone 122887 mariner Vansposo 0. 26 455802 BE141491 gb : MRO-HT0080-011099-002-hO6HT0080Homo 0. 26 414003 AA134472 gb : zol3cO1. sl Stratagenecolon (937204) 0. 26 436363 AA843926 Hs. 124434 ESTs 0. 26 456074 BE409525 Hs. 902 neurofibromin 2 (bilateral acoustic neur 0. 26 430569 AF241254 Hs. 178098 angiotensiniconvertingenzyme (peptidy 0. 26 445635 Api769774 Hs. 209831 ESTs, Weakly similar to ALU 1-HUMAN ALU S 0. 26 405953 NA NA 0. 26 411021 F00055 Hs. 172004 titin 0. 26 428443 BE618106 Hs. 184326 CDC10 (cell division cycle 10, S. cerevi 0. 26 434345 AF127772 gb : Homo sapiens cell-line E8CASS clone E 0. 26 455743 BE073754 gb : RCO-BT0561-210100-032-dO7 BT0561 Homo 0. 26 451138 W92287 Hs. 40268 ESTs 0. 26 449528 H63337 Hs. 38178 hypothetical protein FLJ23468 0. 26 441040 AW449782 Hs. 178803 ESTs 0. 26 458830 AW501248 Hs. 250824 Homo sapiens cDNA : FLJ23435 fis, clone H 0. 26 428861 AW352234 Hs. 269365 ESTs, WeaklysimilartoALU8 HUMANALUS 0. 26 435469 AW388237 Hs. 191204 ESTs 0. 27 427562 R56424 Hs. 26534 ESTs 0. 27 434779 AF153815 Hs. 50151 potassium inwardly-rectifying channel, s 0. 27 423528 AB011137 Hs. 300938 KIAA0565 gene product 0. 27 406589 NA 0. 27 450059 BE220223 Hs. 279626 ESTs 0. 27 417296 L36196 Hs. 81884 sulfotransferaefamily, cytosolic, 2A, 0. 27 454007 AW015870 Hs. 232081 ESTs 0. 27 426062 N57014 Hs. 75874 pregnancy-associated plasma protein A 0. 27 441665 Ai301355 Hs. 151285 ESTs 0. 27 405037 NA NA 0. 27 446820 AW295037 Hs. 254986 ESTs 0. 27 448487 A1523720 Hs. 172567 ESTs 0. 27 447567 AW474513 Hs. 224397 ESTs, Weakly similar to 138931 Wiskott-A 0. 27 408540 L13220 Hs. 639 calbindin 3, (vitamin D-dependent calciu 0. 27 407601 AC002300 Hs. 37129 sodiumchannef. nonvoitage-gated1. beta 0. 27 432501 BE546532 Hs. 25682 Homo sapiens mRNA for KIAA1863 protein, 0. 27 401350 NA NA 0. 27 417569 R00271 Hs. 144651 ESTs 0. 27 443542 A1927065 Hs. 146040 ESTs 0. 27 437105 AA744554 Hs. 222127 ESTs 0. 27 432119 T80289 Hs. 302041 Homo sapiens clone 24762 mRNA sequence 0. 27 419056 M89957 Hs. 89575 CD79B antigen (immunoglobulin-associated 0. 28

427812 AA770424 Hs. 98162 ESTs 0. 28 423557 AB011176 Hs. 129801 KIAA0604 gene product 0. 28 445311 AW027556 Hs, 156286 ESTs 0. 28 402758 NA NA 0. 28 448240 Al478345 Hs. 191034 ESTs 0. 28 401333 NA NA 0. 28 444107 T46839 Hs. 10319 UDP glycosyltransferase 2 family, polype 0. 28 454738 BE072139 gb : PM1-BT0533-291299-002-b05 BT0533 Homo 0. 28 442896 R37725 Hs. 261108 ESTs 0. 28 447949 A1446820 Hs. 165839 EST 0. 28 435625 H50654 Hs. 113999 ESTs 0. 28 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 0. 28 438380 T06430 Hs. 6194 chondroifin suHate proteoglycan BEHAB2o 0. 28 442967 A1025460 Hs. 220977 ESTs 0. 28 448062 AW295923 Hs. 255472 KIAA1843 protein 0. 28 425860 L29339 Hs. 1964 solutecanierfamilyS (sodiumiglucose 0. 28 451839 A1820516 Hs. 16857 ESTs 0. 28 446000 AV656052 Hs. 1504 hemopexin 0. 28 443506 H10661 Hs. 192124 ESTS, Weakly similar to 138022 hypotheb 0. 28 418345 AJ001696 Hs. 241407 serine (or cysteine) proteinase inhibito 0. 28 445481 AW661846 Hs. 148836 ESTs 0. 28 409337 H71289 Hs. 220535 ESTs 0. 28 411414 AW897236 gb : CMO-NN0057-150400-335-cQ6NN0057Homo 0. 28 427642 R40761 Hs. 9834 ESTs 0. 28 456392 W28766 gb : 51d3 Human retina cDNA randomly prime 0. 28 409920 BE169746 Hs. 12504 likely ortholog of rtrouse Arkadia 0. 28 410285 AA083609 gb : zm63dO5. r1 StratageneEbroblast (937 0. 28 442496 R55073 Hs. 124130 ESTs 0. 28 423770 AW976766 Hs. 132776 Homo sapiens cDNA FW 10077 hs, clone HE 0. 28 423467 AK000214 Hs. 129014 hypothetical protein FLJ20207 0. 29 458716 N99013 Hs. 16762 Homo sapiens mRNA ; cDNA DKFZp564B2062 (f 0. 29 423235 AW410698 Hs. 169917 neurabin 11 0. 29 431087 H12723 Hs. 290791 ESTs 0. 29 459106 AW589793 Hs. 224713 ESTs 0. 29 414870 N72264 Hs. 300670 KIAA1204 protein 0. 29 402243 NA 0. 29 432628 R02394 Hs. 269436 ESTs, ModeratelysimilartoPC4259fem 0. 29 404364 NA NA 0. 29 400480 NA 0. 29 456083 U46922 Hs. 77252 fragile histidine triad gene 0. 29 446598 AW250546 gb : 2821774. 5prime NIH_MGC_7 Homo sapiens 0. 29 422201 NM 001505 Hs. 113207 G protein-coupled receptor 30 0. 29 443919 Al091284 Hs. 135224 ESTs. Weakly similar to A47582 Bcell gr 0. 29 453948 A1970797 Hs. 64859 ESTs 0. 29 403792 NA NA 0. 29 418957 Al792615 Hs. 188712 ESTs 0. 29 457960 AA771881 Hs. 298149 ESTs 0. 29 404269 NA 0. 29 439309 AF090097 Hs. 6524 Homo sapiens clone IMAGE 25997 0. 29 458239 BE439877 Hs. 283389 ESTs 0. 30 414941 C14865 Hs. 332341 ESTs 0. 30 404954 NA 0. 30 441609 Axa946764 Hs. 133460 ESTs 0. 30 426895 AA416880 Hs. 225738 ESTs 0. 30 403182 NA NA 0. 30 402319 NA 0. 30 429699 A1383469 Hs. 159300 ESTs 0. 30 405669 NA NA 0. 30 459312 AF107457 Hs. 37035 homeoboxHB9 0. 30 431853 AA521034 Hs. 70834 ESTs 0. 30 449768 A1972746 Hs. 102945 ESTs, Weaklysimilartol78885sennelth 0. 30 443609 AV650231 Hs. 282941 ESTs, Highly similar to A Chain A, Human 0. 30 454293 H49739 Hs. 134013 ESTs, Moderately similar to HK61_HUMAN H 0. 30 447569 Api393202 Hs. 147554 hypothetical protein FLJ23392 0. 30 400128 NA NA 0. 30 423208 AA323191 Hs. 137064 cytoplasmic polyadenylation element bind 0. 30 434227 AF119893 Hs. 63382 hypotheGcalproteinPR02714 0. 30 424208 AW583123 Hs. 143113 pancreaticlipae-reiatedprotein2 0. 30 401165 NA NA 0. 30 415394 R19249 Hs. 22654 sodium channel, voltage-gated, type 1, a 0. 30 443110 AW352243 Hs. 132665 ESTs 0. 30 426724 AA383623 Hs. 293616 ESTs 0. 30 416035 H42314 gb : yoO9eO2. s1 Soares æull brån N2bSHB5 0. 30 409753 AA234847 gb : zs37b10. ri Soares_NhHMPu_S1 Homosapi 0. 31 459221 BE246522 Hs. 306121 leukocytereceptorcluster (LRC) encoded 0. 31 408895 AA058730 Hs. 191464 ESTs 0. 31 405110 NA NA 0. 31 432430 AW079984 Hs. 262480 ESTs, Weakly similar to PIHUB6 salivary 0. 31 426442 AA378656 Hs. 106510 ESTs, Moderately similar to ALU2 HUMAN A 0. 31 411765 H43346 gb : ypO9aO4. r1 Soares breast 3NbHBst Homo 0. 31 431854 AA383550 Hs. 271699 polymerase (DNA directed) iota 0. 31 457553 A1861896 Hs. 304505 ESTs 0. 31 412301 AW936328 gb : QV4-DT0021-281299-070-f07DT0021Homo 0. 31

418626 AW299508 Hs. 135230 ESTs 0. 31 416156 Z41922 gb : HSC03B101 normalized infant brain cDN 0. 31 416275 H42823 Hs. 155742 glyoxylate reductaselhydroxypyruvate red 0. 31 419091 T85332 Hs. 178294 ESTs 0. 31 420118 AW295297 Hs. 182585 KlM1276protein 0. 31 451094 Api949825 Hs. 260395 ESTs 0. 31 403214 NA NA 0. 31 412717 W00973 Hs. 334728 ESTs 0. 31 428782 X12830 Hs. 193400 intedeukin 6 receptor 0. 31 449202 AW295154 Hs. 255396 ESTs 0. 31 433138 AB029496 Hs. 59729 semaphorin sem2 0. 31 436602 A1793222 Hs. 166817 ESTs 0. 31 424844 D61524 gb : HUM413E07B Contech human fetal brain 0. 32 435253 W91884 gb : zh47fU8. sl Soares_fetal-liver_spleen-0. 32 455350 AW901809 gb : QVO-NN1020-170400-195-h02 NN1020 Homo 0. 32 416320 H47867 Hs. 34024 ESTs 0. 32 406333 NA 0. 32 443652 A1080692 Hs. 134229 ESTs, Weakly similar to 154401 hypertens 0. 32 457103 A1421187 Hs. 189192 ESTs, Weakly similar to T COMPLEX TESTIS 0. 32 423593 AA328144 gb : EST31752 Embryo, 12 week I Homo sapie 0. 32 453242 T98327 Hs. 18343 ESTs 0. 32 456281 AA284166 Hs. 84113 cyclin-dependentkinaeinhibitor3 (CDK 0. 32 403847 NA NA 0. 32 458711 AL036877 Hs. 282878 ESTs 0. 32 406242 NA NA 0. 32 433493 AA594915 Hs. 155087 ESTs 0. 32 458147 AW752597 gb : IL3-CT0214-161299-045-B06 CT0214 Homo 0. 32 437403 Al208149 Hs. 121196 ESTs 0. 32 407823 D44744 Hs. 247447 ESTs 0. 32 457300 AW297436 Hs. 158849 Homo sapiens cDNA : FLJ21663 fis, clone C 0. 32 436089 AA804957 Hs. 119840 ESTs 0. 32 457463 AW877031 Hs. 272321 hypothetical protein FW12571 0. 32 433370 A1084343 Hs. 122310 ESTs 0. 32 436298 AW293496 Hs. 180138 ESTs 0. 32 419768 T72104 Hs. 93194 apolipopnztein A-l 0. 33 449428 Api651280 Hs. 195685 ESTs 0. 33 406291 NA NA 0. 33 409699 BE154650 gb : PM3-HT0344-071299-003-cO8 HT0344 Homo 0. 33 418162 T11958 gb : A802RHeartHomosapienscDNAcloneA 0. 33 408316 AW807771 gb : MR4-ST0098-090300-003-cO5 ST0098 Homo 0. 33 404187 NA NA 0. 33 452992 Api792376 Hs. 31290 Homo sapiens clone 23832 mRNA sequence 0. 33 448355 A1493734 Hs. 329374 ESTs 0. 33 442423 BE326264 Hs. 246842 ESTs 0. 33 439474 A1824060 Hs. 211501 ESTs 0. 33 457149 AA429575 Hs. 297493 ESTs 0. 33 448623 BE613468 Hs. 107515 ESTs, Weakly similar to T00329 hypotheti 0. 33 454790 AW820852 gb : RC2-ST0301-120200-011-f12ST0301Homo 0. 33 419372 W28781 gb : Slh3HumanreUnacDNArandomlyprime 0. 33 406293 NA NA 0. 33 422933 AF073931 Hs. 122359 calcium channel, voltage-dependent, alph 0. 33 451818 A1819018 Hs. 339668 ESTs 0. 33 441912 AA971484 Hs. 159938 ESTs 0. 33 429013 AJ012590 Hs. 194728 hexose-6-phosphatedehydrogenase (glucos 0. 33 422304 AK002016 Hs. 114727 Homo sapiens, clone MGC : 16327, mRNA, com 0. 33 457394 M86528 Hs. 266902 neunotrophin 5 (neurotrophin 415) 0. 33 406597 NA 0. 33 451636 AW173270 Hs. 140444 ESTs 0. 33 424226 N94153 Hs. 19155 ESTs 0. 33 TABLE 47B : Pkey : Unique Eos probeset identifier number CAT number. Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 408316 1051210-1 AW807771 AW179260 AW807851 AW179240 AW845961 AW807693 BE141176 AW807594 AW807772 AW846003 AW845963 AW179239 409382 1125081 AA071244AA071477 409699 11490331 BE154650 BE154785AW468343BE154816BE154667 409753 115305 1 AA234847 AA077472 409828 1155571 1 AW501137AW501295AW501212 410285 119128_1 M083609M083790M112048 411414 12450241 AW897236AW845406 411765 125700_1 H43346 M248302 M095182 412301 12881231 AW936328AW936539 412793 1327636-1 AW997986 413382 1365954 1 BE090689 BE090685 BE090697 BE090680 BE090691 BE090696 BE090698 BE090686 414003 140888_1 M134472 R76288 AW750262 414383 1440279 1 BE279406 BE280100 415327 1534137 1 H22769 R35182 Z43545 F05783 N92089 H71928 416035 1567254 1 H42314 H43080 H45217 H15384 416156 1573980 1 Z41922 H23072 T77322 418162 1725383_1 T11958 T11756 T11816 T20135 T19729 R45874

419372 1842942 1 W28781 W26588 W26377 422731 220507_1 AL138411 AL138412M315860 423593 2299551 AA328144 AW962385 N30457 424844 244291 1 D61524M347654AW961758 429446 304683 1 AI547111 AW973749 AA558007 430350 3164011 BE169639AA476976 434345 384111 AF127772AF062358AF060217AA652270F23288 434597 389383 1 AW974668 AA661959 AA649572 AA640401 AA640402 435253 403478_1 W91884W95119M676941 435447 406400 1 Al872932 M682306 BE220163 W88695 T81307 H91447 437333 436167 1 M748898AW997701 AW997703 439657 47499 1 W93589 W93487 AF086493 439780 476731 AL109688 R23665 R26578 446598 68463_1 AW250546 BE257108 BE251006 BE255957 BE250926 BE513012 AV659318 447677 732252_1 Al419235 AW055016 BE007490 BE550241 448643 773566-1 A1557531 450736 844652 1 AW970060 AI732366 AI792313 AW839644 454282 1091035 1 AW296422 H72616 H63825 454633 1227504 AW811380AW811385 454738 1232449_1 BE072139 BE157977 BE 157974 AW857974 AW817778 454790 12347521 AW820852AW820773AW821088 455071 1252281 1 BE145826 BE145815 BE145822 AW854707 BE145912 455308 1278147 1 AW893949AW893960AW893966 455350 1283853 1 AW901809 AW901787 AW901795 AW901792 AW901744 AW901753 AW901807 AW901798 455391 1288067_1 BE156230 BE156239AW936260 455699 1351258_1 BE068121 BE068090 BE068153 BE068128 BE068197 BE068136 BEû68140 BEQ6818S BE068105 455743 1354978 1 BE073754 BE073753 BE073755 BE073756 BE073752 BE073795 BE073796 BE073704 BE073791 BE073733 BE073695 455802 1370828 1 BE141491 BE141016 BEt41479 455826 1373392 1 BE144228 BE144291 455968 1391117 1 BE168828 BE168830 BE168823 BE 168928 BE 168820 BE 168826 456328 1789791 1 T41368 T41369 T41294 456392 1843059 1 W28766 W26500 458147 488021 1 AW752597 AW848781 AW849062 AW848490 AW752699 AW752604 AW752700 459233 944881 1 A1939966 A1939988 A1939951 A1939981 A1939976 A1939959 TABLE 47C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et al. refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489 495. Strand : Indicates DNA strand from which exons were predicted. NLposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 400480 8439796 Minus 110553-111119 401015 8117441 Plus 72260-72369 401042 8117611 Plus 151364-151606 401132 8705350 Minus 85679-85795 401165 9438376 Minus 168244-168423 401333 9884881 Plus 13852-14861 401350 9931226 Plus 14471-14623 401623 8575907 Plus 163249-163623 401683 7689961 Plus 2934-3446 401685 7689961 Minus 8038-8319 402015 7417802 Minus 48791-49043, 50038-50205, 51530-51672, 54448-54565, 55933-56073 402243 7690137 Minus 196521-196721 402319 7582559 Plus 116589-117549 402750 7210067 Plus 69466-69678, 71139-71284, 71572-71865 402758 9213869 Plus 87638-87924 402760 9213869 Plus 136820-136952, 137336-137521 402790 4835258 Minus 147744-147861 403182 9838273 Plus 102163-102345, 102545102725 403214 7630945 Minus 76723-77027, 79317-79484 403652 8705848 Minus 49991-50129 403670 7259739 Minus 88377-88537 403697 3962501 Minus 102965-103174 403792 7230192 Minus 149707-149873 403847 7708844 Plus 317240-317391, 317913-318032 403941 7454203 Plus 114876-115342 404097 7770701 Plus 55512-55781 404145 9863643 Plus 30607-31266 404187 4481839 Plus 7644-7991 404269 9711443 Plus 70261-70404, 72944-73063 404364 9964977 Minus 32986-33202 404401 7259738 Plus 71066-71326 404753 7637341 Plus 14770-14931 404848 8248647 Minus 23955-24034, 25143-25264 404900 7331453 Plus 22032-22219 404954 7387327 Plus 131720-132042 405037 7543748 Minus 127374-127578 405110 8096888 Minus 118940-119100 405650 4926905 Minus 71743-72291 405669 4508140 Plus 14130-14270 405953 7960374 Minus 65101-65574

406242 7417725 Minus 36736-36951 406291 5686274 Plus 9562-9867 406293 5686274 Minus 1764G17953 406333 9213235 Plus 64689-64798 406560 7711569 Minus 35162-35292 406589 8224211 Plus 38806-38989 406597 8248613 Minus 132738-132985, 134266-134425, 135034-135192, 135471-135608, 137345137478, 138768-138912 TABLE 48A : ABOUT 426 GENES UPREGULATED IN MELANOMA RELATIVE TO NORMAL BODY TISSUES Table 48A lists about 426 genes upregulated in melanoma relative to normal body tissues. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene btie R1 : Mean of melanoma Als divided by the mean of normal tissue Als, where the minimum value for the numerator and denominator was set to 1. 0 Pkey ExAccn UnigenelD Unigene Title R1 426555 NM 000372 Hs. 2053 tyrosinase (oculocutaneous albinism IA) 376. 61 428655 H05769 Hs. 188757 Homo sapiens, clone MGC : 5564, mRNA, comp 324. 36 430377 NM 001922 Hs. 301865 dopachrome tautomerase (dopachrome delta 231. 30 453344 8E349075 Hs. 44571 ESTs 180. 67 425289 AW139342 Hs. 155530 interferon, gamma-inducible protein 16 107. 36 417166 AA431323 Hs. 42146 ESTs 97. 76 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypothet 96. 76 434826 AF155661 Hs. 22265 pyruvate dehydrogenase phosphatase 94. 52 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 90. 88 438209 AL120659 Hs. 6111 aryl-hydrocarbonreceptornucleartransl 87. 91 443983 H04482 Hs. 163724 ESTs 85. 55 428513 BE220806 Hs. 184697 Homosapiensclone23785mRNAsequence 85. 03 419956 AL137939 Hs. 40096 cadherin 19, type 2 84. 27 423605 AF047826 Hs. 129887 cadhenn 19, type 2 80. 88 430540 AW245422 Homo sapiens cDNA : FLJ22105 fis, clone H 80. 64 416975 NM 004131 Hs. 1051 granzyme B (granzyme 2, cytotoxic T-lymp 79. 09 421633 AF121860 Hs. 106260 sorting nexin 10 71. 52 442064 A1422867 Hs. 88594 ESTs 69. 88 418310 AA814100 Hs. 86693 ESTs 67. 94 423799 AW026300 Hs. 132906 19A24 protein 67. 64 432886 BE159028 Hs. 279704 chromatin accessibility complex 1 63. 24 456508 AA502764 Hs. 123469 ESTs, Weakly similar to AF2088551 BM-01 63. 18 432882 NM 013257 Hs. 279696 seruMglucocorficoid regulated kinase-li 62. 33 454088 AW062425 gb : CMD-CT0042-090899-018-fOl CT0042 Homo 61. 62 430838 N46664 Hs. 169395 hypothetical protein FLJ12015 60. 52 422363 T55979 Hs. 115474 replication factor C (activator 1 3 (38 59. 73 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Circadian Oscillat 59. 33 450800 BE395161 Hs. 1390 proteasome (prosome, macropain) subunit, 59. 00 441224 AU076964 Hs. 7753 calumenin 58. 27 408418 AW963897 Hs. 44743 KIAA1435 protein 56. 79 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 56. 45 456373 BE247706 Hs. 89751 membrane-spanning 4-domains, subfamily A 56. 29 420674 NM 000055 Hs. 1327 butyrylcholinesterase 56. 15 407856 AA045281 Hs. 266175 phosphoprotein associated with GEMs 55. 82 420552 AK000492 Hs. 98806 hypothetical protein 55. 39 442355 AA456539 Hs. 8262 lysosomal-associated membrane protein 2 54. 97 429747 M87507 Hs. 2490 caspase 1, apoptosis-related cysteine pr 52. 85 410174 AA306007 Hs. 59461 DKFZP434C245 protein 52. 00 437396 BE140396 Hs. 21621 hypothetical protein DKFZp7620076 51. 97 409557 BE182896 Hs. 3686 ESTs 51. 64 420301 AA767526 Hs. 22030 paired box gene 5 (B-cell lineage specif 51. 42 414403 AW969551 Hs. 76064 ribosome protein L27a 50. 58 452958 AA883929 Hs. 40527 ESTs 50. 21 458997 AW937420 ESTs 49. 97 458079 Al796870 Hs. 54277 DNA segment on chromosome X (unique) 992 49. 85 435905 AW997484 Hs. 5003 KIAA0456 protein 48. 76 424800 AL035588 Hs. 153203 MyoD family inhibitor 48. 33 426827 AW067805 Hs. 172665 methylenetetrahydrofolatedehydrogenase 47. 91 408548 AA055449 Hs. 63187 ESTs, Weakly similar to ALUC_HUMAN ! ! ! ! 47. 45 420000 AB036063 Hs. 94262 p53-inducible ribonucleotide reductase s 46. 52 419485 AA489023 Hs. 99807 ESTs, Weakly similar to unnamed protein 45. 79 451134 AA318315 Hs. 25999 hypothe6cal protein FU22195 45. 52 430066 Api929659 Hs. 237825 signal recognition particle 72kD 45. 45 417427 M90391 Hs. 82127 interleukin 16 (lymphocyte chemoattracta 44. 58 450447 AF212223 Hs. 25010 hypothetical protein P15-2 43. 36 446019 Al362520 histone deacetylase 3 43. 03 430015 AW768399 ESTs 42. 45 446880 A1811807 Hs. 108646 Homo sapiens cDNA FLJ 14934 fis, clone PL 42. 36 409327 L41162 Hs. 53563 collagen, type IX, alpha 3 42. 30 425390 A1092634 Hs. 156114 protein tyrosine phosphatase, non-recept 41. 42 411088 BE247593 Hs. 145053 ESTs 41. 21 408527 AL135018 Hs. 33074 Homo sapiens, clone IMAGE : 3606519, mRNA, 40. 94 441590 A1623207 Hs. 190537 ESTs 40. 66

457465 AW301344 Hs. 122908 DNA replication factor 39. 91 430280 AA361258 Hs. 237868 intedeukin 7 receptor 38. 91 410700 AA352335 Hs. 65641 hypothetical protein FLJ20073 38. 70 421282 AA286914 Hs. 40782 ESTs 38. 55 448275 BE514434 Hs. 20830 kinesin-like 2 38. 00 453912 AL121031 SWIISNF related, matix associated, acti 37. 94 414844 AA296874 Hs. 77494 deoxyguanosinekinase 37. 88 421305 BE397354 Hs. 324830 diptheria toxin resistance protein requi 37. 70 439352 BE614347 Hs. 169615 hypothetical protein FU20989 37. 64 409078 AW327515 ESTs 37. 30 449845 AW971183 Hs. 6019 DnaJ (Hsp40) homolog, subfamily C, membe 37. 27 444184 T87841 Hs. 282990 Human DNA sequence from clone RP1-28H20 37. 21 445819 Api767472 Hs. 146290 ESTs, Weakly similar to putative p150 [H 37. 21 451418 BE387790 Hs. 26369 hypothetical protein FLJ20287 37. 00 433226 AW503733 Hs. 9414 KIAA1488 protein 36. 88 445784 Api253155 Hs. 146065 ESTs 35. 36 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 33. 09 407756 AA116021 Hs. 38260 ubiquitin specific protease 18 32. 05 447937 AL109716 Hs. 20034 Homo sapiens mRNA full length insert cDN 31. 00 438549 BE386801 Hs. 21858 trinudeotide repeat containing 3 30. 76 429083 Y09397 Hs. 227817 BCL2-related protein A1 30. 73 444670 H58373 Hs. 332938 hypothetical protein MGC5370 28. 45 446839 BE091926 Hs. 16244 mitoUcspind ! ecoiled-coilnelatedprot 27. 62 433576 BE080715 Hs. 161091 ESTs 27. 42 422173 BE385828 Hs. 250619 phorbolin4ikeproteinMDS019 (CEM15) 27. 36 408962 BE386436 Hs. 44317 SRY (sex determining region Y)-box 10 26. 66 442757 A1739528 Hs. 28345 ESTs 25. 94 414646 AA353776 Hs. 901 CD48 antigen (B-cell membrane protein) 25. 39 433675 AW977653 Hs. 75319 ribonucleoUde reductase M2 polypeptide 24. 55 438461 AW075485 Hs. 286049 phosphoserineaminotransferase 22. 48 427581 NM 014788 Hs. 179703 KIAA0129 gene product 22. 15 435256 AF193766 Hs. 13872 cytokine-likeproteinC17 20. 61 409988 N27687 Hs. 334334 transcription factor AP-2 alpha (activat 19. 79 444863 AW384082 Hs. 104879 serine (or cysteine) proteinase inhibito 19. 73 417404 NM 007350 Hs. 82101 pleckstrin homology-like domain, family 19. 27 458098 BE550224 metallothionein 1E (functional) 18. 09 417018 M16038 Hs. 80887 v-yes-1 Yamaguchi sarcoma viral related 16. 95 446054 AB014537 Hs. 13604 KIAA0637 gene product 15. 67 432606 NM 002104 Hs. 3066 granzyme K (senne protease, granzyme 3 ; 15. 54 414696 AF002020 Hs. 7691 8 Niemann-Pick disease, type Cl 15. 06 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 14. 89 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 14. 84 422486 BE514492 Hs. 117487 genenearHDon4pl6. 3wiühhomologyto 14. 61 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 14. 12 421334 BE297729 gb : 601175625F1 HMGC17 Homo sapiens c 13. 94 422423 AF283777 Hs. 116481 CD72 antigen 13. 77 408996 AI979168 Hs. 344096 glycoprotein (transmembrane) nmb 13. 33 416406 D86961 Hs. 79299 lipoma HMGIC fusion partner-like 2 12. 76 427536 BE277141 Hs. 115803 gb : 601178666F1 NlH_MGC_20Homosapiensc 12. 76 423198 M81933 Hs. 1634 cell division cycle 25A 12. 66 430770 AA765694 Hs. 123296 ESTs 12. 58 407833 AW955632 Hs. 66666 ESTs, Weakly similar to S19560 proline-r 12. 09 430822 AJ005371 Hs. 248017 glyceraidehyde-3phosphatedehydrogenase 11. 46 424259 AK001776 Hs. 143954 hypothetical protein FLJ10914 10. 58 446950 AA305800 Hs. 5672 hypothetical protein AF140225 10. 04 420956 AA351584 Hs. 100543 Homo sapiens clone 24505 mRNA sequence 9. 98 448356 AL120837 Hs. 20993 high-glucose-regulated protein 8 9. 88 428799 A1478619 Hs. 104677 ESTs 9. 56 437271 AL137445 Hs. 28846 Homo sapiens mRNA ; cDNA DKFZp5660134 (fr 9. 03 447769 AW873704 Hs. 320831 Homo sapiens cDNA FLJ 14597 fis, clone NT 9. 01 408393 AW015318 Hs. 23165 ESTs 8. 99 407966 AA295052 Hs. 38516 Homo sapiens, done MGC : 15887, mRNA, com 8. 99 450534 A1570189 Hs. 25132 KIAA0470 gene product 8. 91 410101 Api338045 Hs. 203559 hypothetical protein FLJ12701 8. 90 417129 Al381800 Hs. 300684 calcitonin gene-related peptide-receptor 8. 86 453507 AF083217 Hs. 33085 WD repeat domain 3 8. 68 442739 NM 007274 Hs. 8679 cytosolic acyl coenzyme A thioester hydr 8. 46 456249 A1206144 Hs. 82508 HRIHFB2206 protein 8. 38 437786 BE142681 Hs. 155573 polymerase (DNA directed), eta 8. 35 448410 AK000227 Hs. 21126 hypothetical protein FU20220 8. 20 44271 f AF151W3 Hs. 8645 hypotheGcal protein 8. 14 408405 AK001332 Hs. 44672 hypothetical protein FLJ10470 7. 96 420208 BE276055 Hs. 95972 silver (mouse homolog) like 7. 88 415929 AA724373 Hs. 49344 hypothetical protein FW11006 7. 79 449217 AA278536 Hs. 23262 nbonuciease, RNaeAfamily, k6 7. 66 451239 H24302 Hs. 23127 ESTs 7. 50 442426 Al373062 Hs. 332938 hypothetical protein MGC5370 7. 40 447233 AW246333 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 7. 39 439574 A1469788 ESTs 7. 13 431360 NM000427 Hs. 251680 loricrin 7. 12 412438 A1087928 Hs. 110741 ESTs 6. 96 452882 AW972990 Hs. 196270 folate transporter/carier 6. 87 436581 AA725726 Hs. 180213 ESTs 6. 64

431317 AA502682 gb : ng23d01. s1NCLCGAPOv2 Homo sapiens 6. 63 443264 BE221477 Hs. 132137 EsTsBModeratelysimilartoA47582B-cel 6. 58 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 6. 53 408367 AK001178 Hs. 44424 homolog of rat orphan transporter v7-3 6. 52 413283 R78669 Hs. 23756 hypothetical protein similar to swine ac 6. 50 453878 AW964440 Hs. 19025 DC32 6. 48 424148 BE242274 Hs. 1741 integrin, beta7 6. 44 407876 NM 004519 Hs. 40866 potasiumvoltage-gatedchannel, KQT-lik 6. 44 409512 AW979187 Hs. 293591 melanoma differentiation associated prot 6. 39 427951 A1826125 Hs. 43546 ESTs 6. 32 448664 AI879317 Hs. 334691 splicingfætor3a, subunitl, 120kD 6. 03 416640 BE262478 Hs. 79404 neuron-specific protein 6. 01 446830 BE179030 HumanDNAsequencefromcloneRPS1174N9 5. 98 452629 W02772 Hs. 180178 Homo sapiens, clone IMAGE : 3947276, mRNA, 5. 93 427390 At432163 Hs. 268231 Homo sapiens cDNA : FLJ23111 fis, clone L 5. 73 427853 A1569798 Hs. 98260 ESTs 5. 55 434398 AA121098 Hs. 3838 serum-inducible kinase (SNK) 5. 54 450256 AA286887 Hs. 24724 MFH-amplified sequences with leucine-ric 5. 54 428524 AA429772 ESTs 5. 53 431797 BE169641 Hs. 270134 hypothetical protein FU20280 5. 50 418403 D86978 Hs. 84790 KIAA0225 protein 5. 50 411524 AW850303 gb : lL3-CT0219-191199030-F09CT0219Homo 5. 47 426158 NM 001982 Hs. 199067 v-erb-b2 avian erythnoblatic ieukemia v 5. 40 443086 AW977125 sine oculis homeobox (Drosophila) homolo 5. 38 447735 AA775268 Hs. 6127 Homo sapiens cDNA : FLJ23020 fis, clone L 5. 38 406843 AW196933 Hs. 119598 ribosoma protein L3 5. 36 430594 AK000790 Hs. 246885 hypothetical protein FLJ20783 5. 35 447674 BE270640 Hs. 19192 cyclin-dependent kinase 2 5. 23 410491 AA465131 Hs. 64001 Homo sapiens clone 25218 mRNA sequence 5. 23 420338 AA825595 Hs. 88269 Homo sapiens, clone MGC : 17339, mRNA, com 5. 09 409264 NM 014937 Hs. 52463 KIAA0966 protein 5. 03 414734 AA151712 Hs. 82572 ESTs 5. 01 426759 A1590401 Hs. 21213 ESTs 4. 99 426793 X89887 Hs. 172350 HIR (histone cell cycle regulation defec 4. 98 428612 AA770001 ESTs 413550 W03011 Hs. 306881 MSTP043 protein 4. 92 447349 A1375546 gb : tc23dO4. x1 Soares_total_fetus_Nb2HF8_ 4. 86 403328 Target Exon 4. 85 452840 A1097393 Hs. 43481 hypothetical protein DKFZp564K192 4. 83 439310 AF086120 Hs. 102793 ESTs 4. 82 451281 A1768965 Hs. 292708 ESTs 4. 82 431183 NM 006855 Hs. 250696 KDEL (Lys-Asp-Glu-Leu) endoplamic neUc 4. 81 427871 AW992405 Hs. 59622 Homo sapiens, clone IMAGE : 3507281, mRNA, 4. 74 435963 AF271212 Hs. 322901 disrupter of silencing 10 4. 67 418699 BE539639 Hs. 173030 ESTs, WeaklysimilartoALU8 HUMANALUS 4. 66 414770 BE257224 Homo sapiens, clone IMAGE : 3873720, mRNA 4. 66 419628 H67546 Hs. 49768 ESTs 4. 64 420258 AA477514 Hs. 96247 translin-associated factor X 4. 63 446341 AL040763 Hs. 310735 ESTs, Moderately similar to ALU7 HUMAN A 4. 58 420267 N37030 Hs. 173337 ESTs 4. 57 412228 AW503785 Hs. 73792 comptement component (3d/EpsteinBarrvi 4. 55 432888 T86823 gb : yd81a08. s1 Soares fetal liver spleen 4. 55 453258 AW293134 Hs. 32597 nng finger protein (C3H2C3 type) 6 4. 53 418340 NM 013286 Hs. 84162 chromosome 3p21. 1 gene sequence 4. 50 409038 T97490 Hs. 50002 small inducible cytokine subfamily A (Cy 4. 44 447484 AA464839 Hs. 292566 hypothetical protein FU 14697 4. 42 452036 NM 003966 Hs. 27621 sema domain, seven thrombospondin repeat 4. 41 406903 K03121 gb : Human glyceraldehyde-3-phosphate dehy 4. 40 405451 dihydropyrimidinase-like 3 4. 34 434203 BE262677 Hs. 283558 hypothetical protein PR01855 4. 33 450088 AW292933 Hs. 254110 ESTs 4. 31 421535 AB002359 Hs. 105478 phosphoribosylformylglycinamidine syntha 4. 31 415912 H08859 Hs. 206469 ESTs, WeaklysimilartoALU6_HUMANALUS 4. 30 451259 NM 006052 Hs. 26146 Down syndrome critical region gene 3 4. 29 452548 AL050321 Hs. 301532 CRP2 binding protein 4. 28 432195 AJ243669 Hs. 8127 KIAA0144 gene product 4. 24 445101 T75202 Hs. 12314 Homo sapiens mRNA ; cDNADKFZp586C1019 (f 4. 22 425913 AA365799 SEC22, vesicle trafficking protein (S. c 4. 19 423494 AW504365 Hs. 24143 Wiskott-Aldrich syndrome protein interac 4. 18 442092 AW578669 hypothetical protein FLJ12439 4. 16 424954 NM 000546 Hs. 1846 tumor protein p53 (Li-Fraumeni syndrome) 4. 05 427719 A1393122 Hs. 134726 ESTs 4. 04 415310 R16313 gb : yf93h09. rl Soares infant brain 1 NIB H 4. 04 416058 L08895 Hs. 78995 MADS box transcription enhancer factor 2 4. 03 427828 A1024471 Hs. 98232 ESTs 3. 93 410079 U94362 Hs. 58589 glycogenin 2 3. 92 420265 AA766209 Hs. 88087 ESTs 3. 92 426181 AA371422 Hs. 334371 hypothetical protein MGC13096 3. 90 431639 AK000680 Hs. 266175 phosphoprotein associated with GEMs 3. 89 410275 U85658 Hs. 61796 iranscripbonfactorAP-2gamma (æUvat 3. 88 422150 A1867118 calpastatin 3. 87 429238 NM 002849 Hs. 198288 protein tyrosine phosphatase, receptor t 3. 86 418827 BE327311 Hs. 47166 HT021 3. 84

425050 BE391854 Hs. 7970 gb : 601285394F1 NIH_MGC 44Homosapiensc 3. 82 442271 AF000652 Hs. 8180 syndecan binding protein (syntenin) 3. 81 410235 AA082977 gb : znO7hl O. r1 Stratagene hNT neuron (937 3. 79 408636 BE294925 Hs. 46680 CGI-12 protein 3. 78 424624 AB032947 Hs. 151301 Ca2ependentactivator protein for seer 3. 76 411400 AA311919 Hs. 69851 nucleolarproteinfamilyA, memberl (H/3. 74 458215 AA928160 gb : on86f10. s1SoaresNFLTGBCS1 Homos 3. 73 452874 AK001061 Hs. 30925 hypothetical protein FLJ10199 3. 72 442643 U82756 PRP4/STK/WD splicing factor 3. 70 447471 AF039843 Hs. 18676 sprouty (Drosophila) homolog 2 3. 70 447644 AW861622 Hs. 108646 Homo sapiens cDNA FLJ14934 fis, clone PL 3. 67 422616 BE300330 Hs. 118725 selenophosphate synthetase 2 3. 64 433160 AW207002 Hs. 134342 TASP for testis-specificadriamycin sens 3. 64 418180 BE618087 Hs. 83724 hypothetical protein MGC5466 3. 62 423032 Api684746 Hs. 119274 RASp21 protein activator (GTPaseactiva 3. 62 425569 AA359597 Hs. 301701 Homo sapiens cDNA FLJ12073 fis, clone HE 3. 62 412156 H29487 Hs. 17110 Homo sapiens mRNA ; cDNA DKFZpU4C2016 ( 3. 61 417426 NM 002291 Hs. 82124 laminin, beta 1 3. 61 407188 AA457592 gb : aa92f11. s1 Stratagene feta) retina 93 3. 61 426600 NM 003378 Hs. 171014 VGF nerve growth factor inducible 3. 61 440760 AK001145 Hs. 284216 hypothetical protein FLJ10283 3. 60 448481 W15284 Hs. 74832 ESTs 3. 59 414111 BE047679 Hs. 152982 hypothetical protein FU13117 3. 59 437862 AW978107 Hs. 5884 Homo sapiens mRNA ; cDNADKFZp586C0224 (f 3. 59 409703 NM 006187 Hs. 56009 Z-5-oligoadenylate synthetase 3 (100 k 3. 59 406981 S71129 acetylcholinesterase (YT blood group) 3. 59 431586 AW971100 Hs. 293189 ESTs 3. 58 415173 AW501735 Hs. 180059 ESTs 3. 57 430512 AF182294 Hs. 241578 U6snRNA-asociatedSm-likeproteinLSm8 3. 57 446126 AW085909 pleckstrin homology domain interacting p 3. 57 409305 AA070078 gb : zm60tO5. rl Stratagene fibroblast (937 3. 57 433867 AK000596 Hs. 3618 hippocalcin-like 1 3. 56 459721 Api299050 Hs. 143835 gb : qn14d12. x1 NCI_CGAP_Lu5 Homo sapiens 3. 56 441412 A1393657 Hs. 159750 ESTs 3. 55 416114 A1695549 Hs. 183868 glucuronidase, beta 3. 55 454870 AW836081 gb : PMO-LT0019-090300-002-el 1 LT0019 Homo 3. 54 443105 X96753 Hs. 9004 chondroitin sulfate proteoglycan 4 (mela 3. 53 444680 Ai186671 Hs. 22670 ESTs 3. 51 413949 AA316077 Hs. 75639 HumanTBlgenemRNA, 3end 3. 51 437033 AW248364 Hs. 5409 RNA polymerase I subunit 3. 50 412141 Al183838 Hs. 48938 hypothetical protein FLJ21802 3. 49 437158 AW090198 KIAA1150 protein 3. 48 432642 BE297635 Hs. 3069 heat shock 70kD protein 9B (mortalin-2) 3. 47 440634 AA921767 Hs. 132447 ESTs 3. 47 445652 AL117473 Hs. 13036 DKFZP727A071 protein 3. 46 429500 X78565 Hs. 289114 hexabrachion (tenacin C, cytotacUn) 3. 43 420460 AA262331 Hs. 48376 Homo sapiens clone HB-2 mRNA sequence 3. 43 426141 C05886 Hs. 293972 ESTs 3. 40 424321 W74048 Hs. 1765 lymphocyte-specific protein tyrosine kin 3. 40 449209 BE616830 Hs. 294145 ESTs 3. 39 408304 AW810279 gb : MR4-ST0125-151299-029-a09ST0125Homo 3. 37 416561 D87328 Hs. 79375 holocarboxylase synthetase (biotin-lprop 3. 35 422947 AA306782 Hs. 122552 G-2 and S-phase expressed 1 3. 34 453005 AW055308 Hs. 31803 ESTs, Weakly similar to N-WASP [H. sapien 3. 34 409430 R21945 Hs. 346735 splicing factor, arginine/serine-rich 5 3. 32 417386 AL037228 Hs. 82043 D123 gene product 3. 32 440999 A1951562 Hs. 126370 ESTs, Weakly similar to CNE3_HUMAN COPIN 3. 31 407516 X64974 gb : H. sapiens mRNA HTPCRH02 for olfactory 3. 31 450065 AL050107 Hs. 24341 transcnphona co-æUvatorwith PDZ-bi 3. 31 416902 AA375634 Hs. 288974 hypothetical protein FLJ12528 3. 28 432878 BE386490 Hs. 279663 Pirin 3. 28 443296 A1765286 Hs. 313342 ESTs 3. 27 429954 A1918130 Hs. 21374 ESTs 3. 25 428044 AA093322 Hs. 301404 RNA binding motif protein 3 3. 25 425317 AW205118 Hs. 210546 interieukin21receptor 3. 25 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 3. 25 432917 NM 014125 Hs. 241517 PR00327 protein 3. 24 447871 BE297946 Hs. 239052 ESTs 3. 24 414829 AA321568 Hs. 77436 pleckstrin 3. 24 426996 AW968934 Hs. 173108 Homo sapiens cDNA : FLJ21897 fis, clone H 3. 23 416188 BE157260 Hs. 79070 v-myc avian myelocytomatosis viral oncog 3. 22 429530 AA454191 Hs. 99362 HumanDNAsequencefromcloneRP11-530N1 3. 21 445174 AV652850 Hs. 172004 mutin 3. 19 459227 AW167599 ESTs 3. 19 439039 A) 656707 Hs. 48713 ESTs 3. 15 418803 U50079 Hs. 88556 histone deæeblae 1 3. 15 420005 AW271106 Hs. 133294 ESTs 3. 15 422511 AU076442 Hs. 117938 coliagen, type XVII, atpha 1 3. 14 452480 Al903526 gb : RC-BT031-090199-063 BT031 Homo sapien 3. 14 445701 AF055581 Hs. 13131 lymphocyte adaptor protein 3. 14 410678 BE540516 Hs. 293732 hypothetical protein MGC3195 3. 14 458664 Api300427 gb : qo18h07. x1 NCl_CGAP_LuSHomosapiens 3.'3 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 3. 13

430441 BE398091 desmoplakin (DPI, DPII) 3. 12 435080 A1831760 Hs. 155111 hypotheticalprotein FLJ14428 3. 12 425606 U52112 Hs. 158331 renin-binding protein 3. 11 432978 AF126743 Hs. 279884 DNAJ domain-containing 3. 11 452826 BE245286 Hs. 301636 peroxisomal biogenesis factor 6 3. 10 446627 A1973016 Hs. 15725 hypothetical protein SBBI48 3. 10 427647 W19744 Hs. 180059 Homo sapiens cDNA FU20653 fis, clone KA 3. 09 417211 T97617 Hs. 269092 ESTs 3. 08 448140 AF146761 Hs. 20450 BCM-like membrane protein precursor 3. 08 448752 AA593867 Hs. 300842 KIAA1608 protein 3. 07 416355 H49875 Hs. 268906 ESTs 3. 07 425345 AU077297 Hs. 155894 protein tyrosine phosphatase, non-recept 3. 07 410321 Y12860 Hs. 62245 soiutecarierfamily25 (mitochondria 3. 07 411395 AA889673 Hs. 7542 KIAA1802 protein 3. 07 416065 BE267931 Hs. 78996 proliferating cell nuclear antigen 3. 06 432343 NM 002960 Hs. 2961 S100 calcium-binding protein A3 3. 06 457991 BE539951 Hs. 306996 Homo sapiens, clone IMAGE : 3447073, mRNA, 3. 05 433201 AB040896 Hs. 21104 KIAA1463 protein 3. 03 416178 A1808527 Hs. 192822 serologically defined breast cancer anb 3. 02 411975 A1916058 Hs. 144583 ESTs 3. 01 448719 AA033627 Hs. 21858 trinucleotide repeat containing 3 3. 00 419870 AW403911 Hs. 266175 phosphoprotein associated with GEMs 3. 00 409601 AF237621 Hs. 80828 keratin 1 (epidemlolytic hyperkeratosis) 2. 94 415668 AW957684 Hs. 306814 hypothetical protein FLJ21889 2. 93 453256 A1565587 Hs. 32556 KIAA0379 protein 2. 81 436856 Al469355 Hs. 127310 ESTs 2. 75 417880 BE241595 Hs. 82848 seiecUnL (lymphocyteadhesionmolecule 2. 60 408209 NM 004454 Hs. 43697 ets variant gene 5 (ets-related molecule Z59 440457 BE387593 Hs. 21321 HomosapienscloneFLB9213PR02474mRNA, 2. 55 415314 N88802 Hs. 5422 glycoprotein M6B 2. 51 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 2. 50 424085 NM 002914 Hs. 139226 replication factor C (activator 1) 2 (40 2. 48 410600 AW575742 ESTs, Moderately similar to S65657 alpha 2. 48 439180 Api393742 Hs. 199067 v-erb-b2aviane~,-hroblaücleukemiav 2. 43 444809 BE207568 Hs. 208219 ocutospanin 2 39 453837 AL138387 Hs. 256126 baculoviral IAP repeat-containing 7 (liv 2. 39 410290 AA402307 Hs. 322844 hypothetical protein DKFZp564A176 2. 37 411358 R47479 Hs. 94761 KIAA1691 protein 2. 35 427550 BE242818 Hs. 311609 nuclear RNA helicase, DECD variant of DE 2. 34 426312 AF026939 Hs. 181874 interferon-inducedproteinwithtetratri 2. 29 448569 BE382657 Hs. 21486 signal transducer and activator of trans 2. 27 418661 NM 001949 Hs. 1189 E2F transcription factor 3 2. 24 459373 BE408266 Hs. 301406 hypothetical protein PP3501 2. 21 417437 U52682 Hs. 82132 interferon regulatory factor 4 2. 21 436700 A1693690 Hs. 301406 hypotheticat protein PP3501 2. 18 450690 AA296696 Hs. 333418 FXYD domain-containing ion transport reg 2. 15 432800 BE391046 Hs. 278962 AIM-1 protein 2. 15 421773 W69233 Hs. 112457 ESTs 2. 09 409415 AA579258 Hs. 6083 Homo sapiens cDNA : FLJ21028 fis, clone C 2. 03 433364 Al075407 Hs. 296083 ESTs, Moderately similar to 154374 gene 2. 02 412609 Z48804 Hs. 74124 ocular albinism 1 (Neftleship-Falls) 2. 01 443950 NM 001425 Hs. 9999 epithelial membrane protein 3 2. 01 451537 R56631 Hs. 26550 retinoid X receptor, gamma 2. 00 427080 AW068287 Hs. 301175 ras-related C3 botulinum toxin substrate 1. 96 413190 AA151802 Hs. 40368 adaptor-related protein complex 1, sigma 1. 94 412926 Api879076 Hs. 75061 macrophage myristoylated alanine-rich C 1. 91 453779 N35187 Hs. 43388 28kD interferon responsive protein 1. 86 453107 NM 016113 Hs. 279746 vanilloid receptor-like protein 1 1. 86 430637 BE160081 Hs. 256290 S100 calcium-binding protein A11 (calgiz 1. 86 408561 Api308037 Hs. 84120 hypothetical protein MGC13016 1. 84 413171 AA318325 Hs. 75219 tyrosinase-related protein 1 1. 83 406016 Target Exon 1. 82 446644 NM 003272 Hs. 15791 transmembrane 7 superfamily member 1 (up 1. 81 431836 AF178532 Hs. 271411 beta-site APPcleaving enzyme 2 1. 77 439496 BE616501 Hs. 32343 Homo sapiens, Similar to RIKEN cDNA 1110 1. 77 447604 AW089933 Hs. 301342 hypothetical protein MGC4342 1. 76 438866 U44385 Hs. 325495 tissue inhibitor of metalloproteinase 2 1. 74 440672 AF083811 Hs. 7345 MAD1 (mitoUc anrest deficient, yeast, h 1. 70 416091 AF295370 Hs. 283082 defensin, beta3 1. 69 446291 BE397753 Hs. 14623 interferon, gamma-inducible protein 30 1. 67 422532 AL008726 Hs. 118126 protective protein for beta-galactosidas 1. 67 418918 X07871 Hs. 89476 CD2 antigen (p50), sheep red blood cell 1. 67 412580 AA113262 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 1. 67 448258 BE386983 Hs. 343214 hypotheticaiprotein FLJ20396 1. 66 414945 BE076358 Hs. 77667 lymphocyte antigen 6 complex, locus E 1. 66 425262 D87119 Hs. 155418 GS3955 protein 1. 65 439237 AW408158 Hs. 318893 ESTs, Weakly similar to A47582 B-cell gr 1. 64 427923 AW274357 Hs. 301406 hypothetical protein PP3501 1. 63 424825 AF207069 Hs. 153357 procollagen-lysine, 2-oxoglutarate 5-dio 1. 62 441859 AW194364 Hs. 94814 interieukin-4 induced gene-1 protein (FI 1. 60 445982 BE410233 Hs. 13501 pescadillo (zebrafish) homolog 1, contai 1. 58 412939 AW411491 Hs. 75069 eukaryotic translation etongation factor 1. 58 417237 H86385 Hs. 81737 pa) thioesterase 2 1. 56

412856 BE386745 Hs. 74631 basigin (OK blood group) 1. 56 447200 BE543146 Hs. 281434 Homo sapiens cDNA FLJ 14028 fis, clone HE 1. 54 409614 BE297412 Hs. 55189 hypothetical protein 1. 53 450663 H43540 Hs. 25292 ribonuclease HI, large subunit 1. 53 423397 NM 001838 Hs. 1652 chemokine (C-C motif) receptor 7 1. 49 425535 AB007937 Hs. 158287 KIAA0468 gene product 1. 48 409340 BE174629 Hs. 321130 hypotheUcalproleinMGC2771 1. 46 446755 AW451473 Hs. 16134 serine/threonine kinae 10 1. 46 454429 BE273437 Hs. 301406 hypothetical protein PP3501 1. 46 425722 Api659076 Hs. 97031 hypothetical protein MGC13047 1. 45 414509 AW161311 Hs. 76294 CD63anUgen (melanoma1antgen) 1. 44 452203 X57522 transporter 1, ATP-binding cassette, sub 1. 43 436378 AJ227874 Hs. 99244 ESTs 1. 42 424218 AF031824 Hs. 143212 cystamin F (leukocystaün) 1. 42 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 1. 42 439740 AL365512 Hs. 6657 hypothetical protein bK1048E9. 5 1. 42 429359 W00482 Hs. 2399 matrix metalloproteinase 14 (membrane-in 1. 42 427634 AI399745 Hs. 18449 hypothetical protein MGC10820 1. 40 403409 NM 005929 : Homo sapiens antigen p97 (mela 1. 40 434262 AF121858 Hs. 12169 sorting nexin 8 1. 34 413566 AW604451 Hs. 285814 sprouty (Drosophila) homolog 4 1. 32 427730 AW250549 Hs. 180577 granulin 1. 32 411742 AW247593 Hs. 71819 eukaryotic translation initiation factor 1. 31 450395 BE048545 Hs. 161757 ESTs 1. 30 413291 NM 006278 Hs. 75268 sialyltransferase 4C (beta-galactosidase 1. 26 442609 AL020996 Hs. 8518 selenoprotein N 1. 24 416929 N20535 meiastatint 1. 21 421975 AW961017 Hs. 6459 hypothetcal protein FU 11856 1. 21 454478 AW805749 superoxide dismutae 2, mitochondrial 1. 20 437723 A1672731 Hs. 13256 ESTs 1. 18 416350 AF188625 Hs. 189507 phospholipase A2, group IID 1. 08 TABLE 48B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 430540 713_2 BC017171 BC012195 NM 007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 131759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 Ai770171 BF196861 BE856897 AA463876 A1375927 AA648810 AA948193 AA490916 A1459893 A1458188 A1240408 A1191843 A1131029 AW768399 AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 Bol227204 BG761305 BE262642 BE391848 BE382475 BG008258 Bl547991 Bl459099 BE391391 BE259420 BE298109 AW245422 A1423847 A1914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 A1359493 BM018598 Al639260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 A1421728 BG767231 BM462953 BG340524 W52648 AAl 13434 BE785431 BIG41981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 81091658 N72512 W58732 W85690 BG958989 Al205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 M812018M740241 Al027722 Al150356 M886395 AW977627 BE220225 AA884082 AW518114 Al243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW6120H6 BE077936 81860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 454088 1007145_1 AW062425AW062411 458997 11847_4 BM453041 AA760783 BE218582 AI340046 AW 166131 BF515854 AI630296 AA461307 A1090881 AW023059 AA155797 AA115486 AL597396 AW889004 AW937420 AA137082 AA013374 BG619478 BG401839 446019 658727_1 Al362520 D25917 A1670784 A1742347 AW269789 Api270700 AW610541 AW793036 AW793035 AW610540 AW362220AW362166 AW362214 AW362225 AW362228 AL119827 430015 713_2 BC017171 BC012195 NM007126 AF100752 AL137377170768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 Bol759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 Ai770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 A1365196 AW337984 AW026150 BE466591 BE674599 A1818438 AA772197 A1651927 AW151143 Bi198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 B1227204 BG761305 BE262642 BE391848 BE382475 BG008258 8154799181459099 BE391391 BE259420 BE298109 AW245422 A1423847 AI914618 H80534 BE301004 AL531791 Al435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 Al359493 BM018598 Api689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 A1421728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 B1041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 B1091658 N72512 W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 Bol262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 A1027722 A1150356 AA886395 AW977627 BE220225 AA884082 AW518114 A) 243844 AA809493 AA481029 AA825718 A1347866 AM31670 AA814436 A) 251109 R07704 AA765606 AA724593 Al918399 Al537550 M491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 But860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 453912 32562_3 BM472224 BI966849 81966735 AW973032 81962894 81963048 AA548765 AI926504 AA041551 AW043754 A1086702 AW008105 AA974849 AW614893 AA553737 M916996AW262982 Al580991 BF726843 AV693312 W35325 AA039927 BG460936 AW388482 AW388420 BF374777 W01360 N94710 H87967 409078 744783_1 AW327515 AW327774 AW327571 458098 23945_1 A1082245 BE467534 AI797130 BE467063 BE467767 BE218421 Al694996 BE327781 BE327407 BE833829 AA989054 AA459718 BE833855 BE550224 AA832519 AF086393 AV733386 BE465409 N29245 W07677 AA482971 BE503548 H18151 AA461301 W79223 W74510 A1090689 AL600773 AL600781 N46003 R28075 R34182 BE071550 AW885857 A1276145 A1276696 H97808 N20540 Api468553 421334 267495 1 BG758353 AA287401 BE295646 AL040858 439574 689966 1 BG532820 AW246001 Al469788 Al350090 Al446788 BE549330 W84862 AA837988 431317 997174_1 AW970601 AW613399 AA503435 AA502682 N91138

446830 41421 1 BC020595 Bol488430 BG168023 BE179030 AW294203 BF849776 AA459064 Al917452AW403072 W27419 BF914568 BF798468 AW370558 T35055 AW370623AA399232 AA214221 AW802987 BF902228 AW370622 BF819597 AW370567 BF914313 AW954040 BF060706 AA194237 T25074 C01285 B1489433 428524 1382184 1 A1208080 AA442862 AA429772 411524 1089114 1 AW850587 AW850589 AW850318 AW850303 443086 256694 BE896316BG819393AA187888AW753122 428612 1383189J AA770001AA431112AA432126 447349 10634U_1 BE743847 AW80$03 BM469626 Al375546 414770 41721_1 AK056926 BG473673 BG482256 AL135566 AW419211 BF949370 AL120313 AV703730 H82569 BG012696 R27084 AA304583 BM452908 BF516419 BF515687 BG036572 BG696740 AW953552 AW859437 AA306038 Al754064 M608729 M664163 H65119 AW272606 BF942099 AW130468 B1089467 BG821499 AA152403 BF310450 BF314240 BG830310 BF803223 BG764269 BE542645 BE259142 R26953 BE257224 BG475461 BF677821 R33048 432888 2155976_1 T86823M570737AI821425M569S9AI732232 425913 4123_2 AV703649 AW959818 A1582119 A1523459 A1674473 AW663543 AA825476 A1935231 BF742805 AA426156 A1253626 AA846477 A1024230 BF221780 AI493027 AW006841 AA814699 H99650 A1088977 AA442691 AI783526 BF207915 A1752847 AA782635 A1978980 AA788634 BG1 19454 BF678528 Al627829 BG993975 AV701283 442092 227562 BM449821 BM069895 BM023170 AW025563 BG152606 BM023452 Al862106 BG959957 415310 1869807-1 R16313 Z45351 R14838 F05290 Rl 4821 R16277 422150 1869807. 1 R16313 Z45351 R14838 F05290 R14821 R16277 AW243344 AI356530 AI492508 AI694049 AIU90422 AA465307 AI273387 BE674625 AW271971 AA969153 AW468593 AA984014 AI817491 AA970258 Al914450 Al018697 AW577591 AW577616 AA382101 AW954455 AI867266 AI707995 AI337384 BF208406 BF037100 BF223433 BF195517 BE673984 BF224124 BE813387 BG036579 Bl553906 M304935 AW361269 AW754160 AW361276 AW361271 Api867118 AW805555 AW361284 AW954458 AW958551 BG681507 H79011 AW205696 AW134957 AA747667 AW753296 BF939060 AW958549 BF910827 BG573750 BGt68639 410235 29302531 AA082977AA082955 458215 5401123 BE176902BE177058 442643 2736_1 BC001588 BC007424 AF016369 NM 004697 81756186 BE257019 BG500792 BI862776 AL121371 BG574833 AA703250 AAi 79511 AWO52006 Al280150 Al914000 AI358319 A1081204 A1082594 AA992449 AI470821 AI655744 AW237529 AA678858 Api984430 BF433055 BE467594 BE467573 M035630 Al289987 Al184802 Al681391 AW592416 AI138377 AI139266 AA961714 AI800163 AA418751 AW451928 AA668676 A1273444 A1494387 BE046912 AI276555 BF196021 AA700055 AA609305 AA772596 AI635758 AI635749 H95459 AW610290 BE464994 AA527136 BF374802 Al800175 AW195227 Al189676 BF802049 AL513632 AL554911 AL538845 BE297273 AA315321 BM451920 BE269268 BE292835 BE018128 BG755713 BM041095 BG677009 AL039691 BF995709 BE735586 BE296453 BG393609 BG824453 AL567522 AI745257 AW388641 AW301265 AI141144 AW029280 AU149362 AU152328 AA418960 AL121009 Api890398 AL528748 H13050 T47086 B1000575 BF334914 BF109661 R44450 H13259 T47087 AW388646 BF305834 AL577515 BM041600 BE889299 BF239768 446126 6102 BF946219 BF946218 BF851494 AL536879 AA457150 A1590194 A1582629 AA464515 AA916242 AA337109 AA336509 N46906 AA336322 AA336407 AA337222 AA319240 B1026817 B1027058 AL536880 AI693827 AA651730 AI701013 BM068789 AW339506 AA293021 8F091 108 A1458885 AW361203 AW974652 Al761251 Ai655763 M628063 BE047125 AW085916 AI129587 N52070 AW772361 AA052951 AW085909 AIGOOOOB AA962570 A1371342 AI364207 AA464514 AI962506 AI824603 AW376300 AA058439 AW361192 AV656660 N50282 BF820514 BF891008 H40784 BF891112 BE708029 AW043567 AA056762 409305 109927 1 AA071475 AA112236 AA070648 AA071243 AA081725 AA085187 AA070078 454870 2170_9 AW836081 BF854404 AW578594 AW578581 BF507971 AW196760 AA779923 AA707233 A1655913 AA948295 AW089222 AW291983 437158 59575-1 AL050068 AA160485 AW173544 AW296506 AW439860 A1521563 Al 702529 Al393606 AW138323 AA570109 H19504 BM021968 BF063327 BF593552 AA630766 Al597717 Al807128 M523012 Al356250 AW451857 AA974203 Al762577 BF512552 AW007307 BE675286 AW450602 AA962057 AW516069 Al582546 BF221924 BF222543Ai801808 AW468599AW000736 Al866625 AW235356 BM021837 M911956 Al680606 W86516 T03370 AW611634 H41653 Al468349 H19588 AW090198 AW043993 R39847 408304 646409 1 AW810279 BE146684 AW810193 AW810515 AW178835 AW810516 BE146689 AW178842 BE146693 BE146694 AW810208 AW810258 AW810447 AW810443 AW810330 AW810211 AW810328 AW810327 AW810288 AW810265 AW810257 AW810263 AW810567 AW178838 AW810323 AW810358 AW810281 AW810321 AW178837 AW810635 BE062400 AW810198 AW810325 AW810513 BE062434 BE146679 AW810441 AW846649 AW810536 AW178857 AW810185 BE146653 AW810636 AW810322 BE146674 AW810359 AW810293 AW810472 AW178852 AW810356 AW810514 AW810289 BE146652 AW810566 459227 639802_1 AW167599 Al971179 Al934948 452480 3144986 1 A1903574 A1903572 A1903526 A1903571 458664 2139033_1 BF432937R07053AI300427W57876 430441 1438 6 BG108218 BE560548 AW380115 BE269629 AI911518 AW380113 AA902964 AA455001 AI276529 AI685597 AA970496 D61084 AW380068 AW380080 R00283 C15236 AW327776 D80759 410600 497855_1 BF347859 AW499616 AA191322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 AI335824 AW408712 BM149172 452203 2630_1 BC014081 NM_000593 X57522 L21208 L21207 L21206 L21205 L21204 AL561404 AL546423 AL560492 AL556882 AL541576 AL550654 B1823519 B1770023 AL554969 81489906 A1304693 AW295947 BMI46642 X57521 BG820143 BE898390 F06770F12630BM423610AL561518 BM009470 BG742981 AA279685 AA847441 AA313737 BF172639 BF897216 BF914190 BF903647 S70277 Al569694 AW073296 AI361433 AA564644 AA487429 BE858232 AA838610 AI539114 AI719375 AI829129 BG057675 A1423422 AU158860 BE300655 AW170777 AA586956 AL571889 AL556850 AL576404 AL582800 B1256544 BF342301 BG875994 AA054458 AA353161 Api940434 BE816522 AL577636 AI479650 AW150377 AU154395 AW951271 Al032220 Al819778 Al346733 AW771150 AW512525 AI249904 AA279809 AI352549 AW512517 BG056280 AA521222 BE271141 AL581932 AL541575 Bu819184 AV660190 AL556475 A1620020 AW089888 AW079179 221518 AA687601 F04651 Al783961 T57198 AI433367 T78652 AL554968 AA365648 AL582619 BE874601 BF804669 AL574458 BM145502 AI266514 AI538823 AI475626 AA948210 AA884054 AA487637 AA031844 AA535221 AW794256 AW361447 BE788505 AI682892 AA830989 AA862356 AA653084 BM009154 AA135727 H05927 H23433 R42244 N79997 AW366665 AW366601 AA678742 AL556474 AA135770 BE774050 BF914200 H88457 M627746 Bl560216 Bl753586 416929 14596 3 BC017849 BC005892 N42983 BF691239 N42991 N29240 N40292 N33322 N33330 N20535 454478 4273_16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 TABLE 48C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitied The DNA sequence of human chromosome 2Z Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_positon : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 403328 8469086 Minus 120428-120703 405451 7622517 Minus 145949-146227 406016 8272661 Plus 41341-41940 403409 9438598 Plus 6860-7054, 1257312771 TABLE 49A : ABOUT 1127 GENES UPREGULATED IN PRIMARY MELANOMA AND/OR MELANOMA METASTASES RELATIVE TO NORMAL BODY TISSUES

Table 49A lists about 1127 genes upregulated in primary melanoma and/or melanoma metastases relative to normal body tissues. These genes were selected from 59680 probesets on the Eos/Aftymethx Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD Unigene number Unigene Title : Unigene gene title R1 : 90th percentile of primary melanoma and melanoma metastasis Als divided by the 90th percenUle of nommaf iissue Als R2 : 90th percentile of primary melanoma and melanoma metastasis Als divided by the 90th percent of normal tissue Als, where the 151h percenGle of normal tissue A (s was subtracted from both the numerator and denominator R3 90th percenlile of primary melanoma and melanoma metastasis Als divided by the 90th percentage of heart, liver, lung, and kidney Als Pkey ExAccn UnigenelD Unigene TiNe R1 R2 R3 452838 U65011 Hs. 30743 preferenüalyexpressedanUgeninmela 14. 05 11. 83 14. 05 426555 NM_000372 Hs. 2053 tyrosinase (oculocutaneous albinism IA) 13. 15 13. 27 13. 15 430377 NM_001922 Hs. 301865 dopæhnometautomerae (dopæhromedelta 11. 77 7. 43 11. 77 420208 BE276055 Hs. 95972 silver (mouse homologe like 10. 53 19. 95 10. 27 431360 NM_000427 Hs. 251680 loricrin 9. 78 7. 09 0. 89 430822 AJ005371 Hs. 248017 glyceradehyde-3^pho5phate dehydrogenae 9. 40 7. 20 8. 84 422168 AA586894 Hs. 112408 S100calcium-bindingproteinA7 (psoas 8. 03 10. 27 12. 84 419628 H67546 Hs. 49768 ESTs 7. 56 8. 92 6. 49 438549 BE386801 Hs. 21858 trinudeotide repeat containing 3 7. 52 5. 47 16. 47 430686 NM_001942 Hs. 2633 desmoglein 1 6. 06 4. 13 3. 31 409601 AF237621 Hs. 80828 keratin 1 (epidertnolytic hyperkeratosis) 5. 86 9. 22 0. 77 429170 NM 001394 Hs. 2359 dual specificity phosphatase 4 5. 84 3. 46 5. 84 428227 Axa321649 Hs. 2248 small inducible cytokine subfamily B (Cy 5. 82 3. 94 5. 82 414812 X72755 Hs. 77367 monokine induced by gamma interferon 5. 81 3. 33 6. 79 453344 BE349075 Hs. 44571 ESTs 5. 78 3. 07 5. 98 425088 AA663372 Hs. 169395 hypotheticatproteinFFUf12015 5. 60 3. 92 5. 60 402075 ENSP00000251056' : Plasmamembranecalcium 5. 12 4. 22 5. 12 416975 NM_004131 Hs. 1051 granzyme B (granzyme 2, cytotoxic T-lymp 5. 09 3. 33 4. 14 420602 AF060877 Hs. 99236 regulator of G-protein signaling 20 5. 06 5. 78 5. 06 426600 NM_003378 Hs. 171014 VGF nerve growth factor inducible 5. 04 6. 77 9. 42 43083B N46664 Hs. 169395 hypotheXcal protein FtJ12015 5. 03 3. 06 5. 03 417542 J04129 Hs. 82269 prdgestagert-associated eadomet6al prote 4. 93 8. 13 5. 41 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypothefi 4. 78 2. 93 4. 78 408962 BE386436 Hs. 44317 SRY (sex determining region Y)-box 10 4. 75 3. 28 5. 30 410361 BE391804 Hs. 62661 guanylatebindingproteinl, interieron-4. 70 3. 11 4. 70 429903 AL134197 Hs. 93597 cyclin-dependent kinase 5, regulatory su 4. 68 2. 27 4. 68 407756 AA116021 Hs. 38260 ubiquiünspecificproteael8 4. 65 3. 21 3. 31 417166 AA431323 Hs. 42146 ESTs 4. 56 5. 23 4. 56 421773 W69233 Hs. 112457 ESTs 4. 52 11. 11 0. 96 442711 AF151073 Hs. 8645 hypotheGcafprotein 4. 37 3. 70 4. 30 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 4. 37 3. 08 6. 75 428513 BE220806 Hs. 184697 Homo sapiens clone 23785 mRNA sequence 4. 32 Z61 4. 32 447937 AL109716 Hs. 20034 Homo sapiens mRNA full length insert cDN 4. 31 3. 13 4. 31 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 4. 28 2. 89 2. 17 433658 L03678 Hs. 156110 immunoglobufinkappaconstant 4. 18 2. 68 5. 92 420301 AA767526 Hs. 22030 pairedboxgene5 (B-celllineagespecif 4. 16 2. 57 4. 16 433447 U29195 Hs. 3281 neun7na pentraxin 11 4. 15 2. 26 6. 46 446341 AL040763 Hs. 310735 ESTs, Moderately similar to AlU7 HUMAN A 4. 10 4. 04 4. 64 408380 AF123050 Hs. 44532 diubiquitin 4. 02 2. 46 5. 33 421379 Y15221 Hs. 103982 small inducible cytokine subfamily B (Cy 4. 02 3. 48 3. 19 421633 AF121860 Hs. 106260 sorfing nexin 10 4. 01 2. 61 3. 36 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 3. 96 2. 68 3. 96 417355 D13168 Hs. 82002 endothelin receptor type 8 3. 95 2. 46 3. 66 420267 N37030 Hs. 173337 ESTs 3. 88 3. 87 3. 88 412228 AW503785 Hs. 73792 complement component (3d/Epstein Barr vi 3. 81 3. 04 7. 94 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 3. 79 2. 23 3. 79 405451 dihydropyrimidinase-like 3 3. 78 3. 74 4. 06 449078 AK001256 Hs. 22975 KIAA1576 protein 3. 76 2. 83 3. 76 423799 AW026300 Hs. 132906 19A24 protein 3. 75 2. 36 3. 75 456373 BE247706 Hs. 89751 membrane-spanning 4-domains, subfamily A 3. 73 2. 59 6. 97 444863 AW384082 Hs-104879 sedne (or cysteine) proteinase inhiuito 3. 72 2. 15 3. 92 427666 A1791495 Hs. 180142 camodulin-likeskinprotein (CLSP) 3. 69 4. 17 1. 18 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 3. 64 2. 08 3. 64 422423 AF283777 Hs. 116481 CD72 antigen 3. 64 2. 94 3. 64 419956 AL137939 Hs. 40096 cadherin 19, type 2 3. 56 2. 22 4. 68 420338 AA825595 Hs. 88269 Homo sapiens, clone MGC : 17339, mRNA, com 3. 55 2. 96 4. 70 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 3. 54 1. 96 3. 54 458079 Al796870 Hs. 54277 DNA segment on chromosome X (unique992 3. 53 2. 18 3. 27 444381 BE387335 Hs. 283713 ESTs, Weakly similar to S64054 hypothefi 3. 48 2. 83 11. 00 449722 BE280074 Hs. 23960 cyclin B1 3. 48 2. 10 4. 64 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 3. 47 3. 90 4. 98 452744 Al267652 Hs. 246107 HomosapiensmRNA ; cDNADKFZp434E082 (fr 3. 45 2. 38 3. 45 447210 AF035269 Hs. 17752 phosphatidytsenne-spedticphosphotipas 3. 44 3. 83 2. 09 428804 AK000713 Hs. 193736 hypothetical protein FU20706 3. 43 2. 39 3. 43 407846 AA426202 Hs. 40403 Cbp/p300-interacting transactivator, wit 3. 41 4. 33 5. 41 423605 AF047826 Hs. 129887 cadherin 19, type 2 3. 40 1. 97 4. 06 421508 NM_004333 Hs. 105115 absent in melanoma 2 3. 38 2. 77 5. 46 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 3. 36 2. 41 3. 36 430770 AA765694 Hs. 123296 ESTs 3. 36 2. 08 3. 83 445784 Al253155 Hs. 146065 ESTs 3. 32 2. 02 3. 80

414646 AA353776 Hs. 901 CD48 antigen (B. cell membrane protein) 3. 32 1. 87 3. 76 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 3. 31 2. 10 3. 31 441224 AU076964 Hs. 7753 calumenin 3. 28 2. 04 3. 28 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 3. 26 2. 43 3. 56 413385 M34455 Hs. 840 indoleamine-pyrrole 2, 3 dioxygenase 3. 24 2. 94 2. 85 416636 N32536 Hs. 42645 solute carrier family 16 (monocarboxytic 3. 23 1. 84 3. 87 415668 AW957684 Hs. 306814 hypotheucal protein FLJ21889 3. 22 3. 10 3. 13 442757 AI739528 Hs. 28345 ESTs 3. 22 3. 41 1. 45 426317 AA312350 Hs. 169294 transcriptionfactor7 (T-ce)) speeifc. 3. 18 Z50 3. 18 432874 W94322 Hs. 279651 melanoma inhibitory activity 3. 18 5. 31 4. 55 412561 NM 002286 Hs. 74011 lymphocyte-activation gene 3 3. 17 3. 09 4. 28 443983 H04482 Hs. 163724 ESTs 3. 16 2. 21 3. 16 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2 doma 3. 14 1. 74 3. 25 422363 T55979 Hs. 115474 neplicafonfactorC (æbvator1) 3 (38 3. 14 2. 07 3. 33 422424 Al186431 Hs. 296638 prostate differentiation factor 3. 10 3. 20 2. 15 435256 AF193766 Hs. 13872 cytokine-like protein C17 3. 10 2. 23 3. 10 401747 Homo sapiens keratin 17 (KRT17) 3. 10 2. 10 3. 02 447674 BE270640 Hs. 19192 cyclin-dependent kinase 2 3. 08 3. 08 4. 00 419870 AW403911 Hs. 266175 phosphoprotein associated with GEMs 3. 07 3. 16 3. 07 432878 BE386490 Hs. 279663 Pirin 3. 06 2. 92 4. 20 401454 NMJ) 14226* : Homo sapiens renal tumor anti 3. 05 1. 96 3. 05 410079 U94362 Hs. 58589 glycogenin 2 3. 01 2. 26 3. 27 426501 AW043782 Hs. 293616 ESTs 3. 01 2. 00 3. 68 418310 AA814100 Hs. 86693 ESTs 3. 00 2. 35 6. 76 422283 AW411307 Hs. 114311 CDC45 (cell division cycle 45, S. cerevis 2. 96 2. 31 3. 78 422309 U79745 Hs. 114924 solutecarierfamilyl6 (monocaboxylic 2. 96 2. 49 4. 74 408418 AW963897 Hs. 44743 KIAA1435 protein 2. 94 1. 80 2. 94 432882 NM013257 Hs. 279696 senum/glucocortcoid regulated kinase-ii 2. 93 1. 74 2. 93 416640 BE262478 Hs. 79404 neuron-specific protein 2. 93 Z78 3. 09 443264 BE221477 Hs. 132137 ESTs, Moderately similar to A47582 B-cel 2. 92 2. 35 4. 27 410491 AA465131 Hs. 64001 Homo sapiens clone 25218 mRNA sequence 2. 91 2. 83 3. 84 405545 Target Exon 2. 90 2. 44 2. 90 451537 R56631 Hs. 26550 retinoid X receptor, gamma 2. 90 4. 09 3. 40 439926 AW014875 Hs. 137007 ESTs 2. 90 2. 43 2. 90 406673 M34996 Hs. 198253 major histocompatibiiity complex, class 2. 89 3. 22 1. 44 418007 M13509 Hs. 83169 matrix meta) ioproteinasel (interstitia) 2. 89 3. 90 2. 89 440065 W03476 Hs. 266331 hypothetica) protein MGC4595 2. 89 4. 40 3. 05 442739 Nu007274 Hs. 8679 cytosolic acyl coenzyme A thioester hydr 2. 88 2. 36 4. 54 424620 AA101043 Hs. 151254 kallikrein7 (chymotlypUc, stratumcom 2. 86 3. 23 1. 95 407856 AA045281 Hs. 266175 phosphoprotein associated with GEMs 2. 84 1. 84 2. 84 430540 AW245422 Homo sapiens cDNA : FLJ22105 fis, clone H 2. 84 1. 80 2. 92 424153 AA451737 Hs. 141496 MAGE-like 2 2. 84 2. 26 2. 84 420798 W93774 Hs. 99936 keratin 10 (epidermolytic hyperkeratosis 2. 81 2. 91 0. 83 431317 AA502682 gb : ng23dO1. sl NCI CGAP_Ov2 Homo sapiens 2. 81 2. 17 2. 96 424800 AL035588 Hs. 153203 MyoD family inhibitor 2. 80 2. 06 4. 10 448111 AA053486 Hs. 20315 interferon-induced protein with tetratn 2. 79 1. 85 2. 42 431183 NM 006855 Hs. 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic retc 2. 78 2. 34 6. 53 448719 AA033627 Hs. 21858 tnnucteotide repeat containing 3 2. 78 3. 75 4. 01 427951 Ai826125 Hs. 43546 ESTs 2. 78 1. 99 2. 70 453912 AL121031 SWI/SNF related, matrix associated, acti 2. 77 2. 28 2. 77 426711 AA383471 Hs. 343800 conserved gene amplified in osteosarcoma 2. 75 1. 98 2. 75 409430 R21945 Hs. 346735 splicing factor, arginine/serine-rich 5 2. 74 3. 18 3. 60 409041 AB033025 Hs. 50081 Hypothetical protein, XP 051860 (KIAA119 2. 72 2. 24 2. 72 442117 AW664964 Hs. 128899 ESTs ; hypothetical protein for iMAGE : 447 2. 72 2. 31 3. 59 420552 AK000492 Hs. 98806 hypothebcal protein 2. 72 1. 85 2. 72 409103 AF251237 Hs. 112208 XAGE-1 protein 2. 72 2. 18 2. 72 439963 AW247529 Hs. 6793 platelet-activating factor acetylhydrola 2. 71 2. 20 4. 48 413171 AA318325 Hs. 75219 tyrosinase-related protein 1 2. 71 5. 74 2. 62 436700 A1693690 Hs. 301406 hypothetical protein PP3501 2. 71 3. 37 3. 32 419098 AA234041 Hs. 87271 ESTs 2. 70 3. 53 1. 35 436608 AA628980 Hs. 192371 down syndrome critical region protein DS 2. 69 2. 48 2. 69 418067 AI127958 Hs. 83393 cystatin EIM 2. 68 3. 04 0. 56 439453 BE264974 Hs. 6566 thyroid hormone receptor interactor 13 2. 67 2. 36 3. 16 437723 Al672731 Hs. 13256 ESTs 2. 66 2. 16 2. 66 411252 A8018549 Hs. 69328 M0. 2protein 2. 66 1. 81 2. 66 424321 W74048 Hs. 1765 lymphocyte-specific protein lyrosine kin 2. 66 2. 43 3. 92 453837 AL138387 Hs. 256126 baculoviral IAP repeat-containing 7 (liv 2. 65 3. 71 2. 80 434826 AF155661 Hs. 22265 pyruvate dehydrogenase phosphatase 2. 64 1. 85 4. 72 414696 AF002020 Hs. 76918 Niemann-Pick disease, type C1 2. 64 2. 07 2. 64 444371 BE540274 Hs. 239 forkhead box M1 2. 64 2. 82 4. 46 436291 BE568452 Hs. 344037 protein regulator of cytokinesis 1 2. 63 1. 81 2. 95 439310 AF086120 Hs. 102793 ESTs 2. 62 2. 38 10. 12 420218 AW958037 ribosomal protein L4 2. 62 2. 80 2. 62 438746 Api885815 Hs. 184727 Human melanoma-associated antigen p97 (m 2. 60 3. 27 2. 12 432828 AB042326 Hs. 287402 chondroitin 4-sulfotransferase 2. 60 2. 67 3. 03 408367 AK001178 Hs. 44424 homologofraiorphantransporterv7-3 2. 59 3. 22 2. 59 408527 AL135018 Hs. 33074 Homo sapiens, clone IMAGE : 3606519, mRNA, 2. 58 1. 69 2. 05 444809 BE207568 Hs. 208219 oculospanin 2. 58 2. 77 2. 88 432886 BE159028 Hs. 279704 chromatin accessibility complex 1 2. 58 1. 83 2. 58 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 2. 55 3. 70 3. 28 412326 R07566 Hs. 73817 smail inducible cytokine A3 (homologous 2. 55 2. 14 1. 62 410174 AA306007 Hs. 59461 DKFZP434C245 protein 2. 55 2. 07 2. 55 447735 AA775268 Hs. 6127 Homo sapiens cDNA : FLJ23020 fis, clone L 2. 54 2. 17 4. 01

422173 BE385828 Hs. 250619 phorbolin-likeproteinMDS019 (CEM15) 2. 53 1. 68 3. 16 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 2. 53 2. 74 3. 93 437396 BE140396 Hs. 21621 hypothetical protein DKFZp7620076 2. 52 1. 62 3. 17 448140 AF146761 Hs. 20450 BCM-like membrane protein precursor 2. 51 2. 67 1. 88 442426 Api373062 Hs. 332938 hypothetical protein MGC5370 2. 51 2. 08 4. 57 417427 M90391 Hs. 82127 interleukin 16 (lymphocyte chemoattracta 2. 51 1. 74 2. 68 427581 NM_014788 Hs. 179703 KIAA0129 gene product 2. 51 1. 67 2. 24 432800 8E391046 Hs. 278962 AIM-1 protein 2. 51 5. 55 2. 42 408996 Api979168 Hs. 344096 glycoprotein (transmembrane) nmb 2. 50 1. 95 241 410326 A1368909 Hs. 47650 ESTs 2. 50 2. 85 2. 63 452833 BE559681 Hs. 30736 KIAA0124 protein 2. 50 3. 14 3. 07 410016 AA297977 Hs. 57907 small inducible cytokine subfamily A (Cy 2. 49 3. 38 2. 91 429083 Y09397 Hs. 227817 BCL2-reiated protein A1 2. 48 1. 85 2. 70 418460 M26315 Hs. 85258 CD8 antigen, alpha polypeptide (p32) 2. 48 2. 33 2. 99 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 2. 47 1. 88 4. 14 412970 AB026436 Hs. 177534 dual specificity phosphatase 10 2. 46 2. 00 0. 98 401780 NM_00555r : Homo sapiens keratin 16 (foca 2. 44 2. 30 1. 39 416426 AA180256 Hs. 210473 Homo sapiens CDNA FU 14872 fis, clone PL 2. 44 1. 57 0. 88 432606 NM 002104 Hs. 3066 granzyme K (serine protease, granzyme 3 ; 2. 42 1. 91 2. 56 417880 BE241595 Hs. 82848 selectin L (lymphocyte adhesion molecule 2. 42 2. 31 4. 27 415929 AA724373 Hs. 49344 hypotheficaf protein FU 11006 2. 41 2. 73 2. 41 415752 BE314524 Hs. 78776 putative transmembrane protein 2. 41 2. 07 3. 41 409703 NM 006187 Hs. 56009 Z-S-oligoadenylate synthetase 3 (100 k 2. 41 2. 34 3. 26 414004 AA737033 Hs. 7155 ESTs, Moderately similar to 2115357A TYK 2. 40 1. 65 2. 40 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 2. 40 2. 18 8. 13 410290 AA402307 Hs. 322844 hypotheücal protein DKFZp564A176 2. 40 2. 88 2. 46 403328 Target Exon 2. 39 2. 00 1. 95 427540 R12014 Hs. 20976 ESTs 2. 39 1. 73 3. 24 449523 NM000579 Hs. 54443 chemokine (C-C moUfj receptor 5 2. 39 1. 96 2. 39 433848 AF095719 Hs. 93764 carboxypeptidae A4 2. 38 2. 45 2. 65 438501 Z44110 Hs. 86149 phosphoinositol3-phosphate-bindingprot 2. 38 1. 85 2. 38 430066 A1929659 Hs. 237825 signa recognition particle 72kD 2. 38 1. 60 2. 79 447343 AA256641 Hs. 236894 ESTs, Highly similar to S02392 alpha-2-m 2. 37 1. 99 6. 23 450447 AF212223 Hs. 25010 hypothetical protein P15-2 2. 37 1. 72 3. 24 458997 AW937420 ESTs 2. 37 1. 57 3. 27 451446 At826288 Hs. 171637 hypotheticat protein MGC2628 2. 35 1. 90 2. 39 408838 A1669535 Hs. 40369 ESTs 2. 35 1. 59 2. 71 448275 BE514434 Hs. 20830 kinesin-like 2 2. 35 2. 19 2. 35 424148 BE242274 Hs. 1741 integrin, beta 7 2. 35 1. 89 3. 07 410700 AA352335 Hs. 65641 hypothetical protein FLJ20073 2. 35 1. 65 2. 35 409105 AW467539 Hs. 255877 ESTs 2. 35 2. 50 2. 35 452882 AW972990 Hs. 196270 folate transporterkanier 2. 34 2. 12 2. 90 425606 U52112 Hs. 158331 renin-binding protein 2. 34 2. 69 1. 69 433576 BE080715 Hs. 161091 ESTs 2. 34 3. 74 2. 34 423494 AW504365 Hs. 24143 Wiskott-Aldrich syndrome protein interac 2. 34 2. 08 4. 48 431620 AA126109 Hs. 264981 Z-5-oligoadenylatesynthetae2 (69-71 2. 33 2. 43 2. 66 436614 AW104388 Hs. 149091 ESTs 2. 33 3. 37 2. 33 425289 AW139342 Hs. 155530 interferon, gamma-inducible protein 16 2. 33 1. 67 4. 28 426827 AW067805 Hs. 172665 methylenetetrahydrofolate dehydrogenase 2. 33 1. 58 0. 40 430015 AW768399 ESTs 2. 33 1. 76 2. 33 421282 AA286914 Hs. 40782 ESTs 2. 32 1. 65 2. 49 447737 AK000643 Hs. 19404 DKFZP564L0862 protein 2. 32 2. 16 1. 48 432540 A1821517 Hs. 105866 ESTs 2. 32 1. 58 2. 35 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 2. 32 2. 46 9. 99 414829 AA321568 Hs. 77436 pleckstrin 2. 32 1. 91 2. 32 425390 A1092634 Hs. 156114 protein tyrosine phosphatase, non-recept 2. 31 1. 63 2. 31 448569 BE382657 Hs. 21486 signaitransducerandaetivatoroftrans 2. 31 2. 79 2. 41 428819 AL135623 Hs. 193914 KIAA0575 gene product 2. 30 1. 60 2. 95 409512 AW979187 Hs. 293591 metanoma differentiation associated prot 2. 30 1. 95 3. 66 425231 AA527161 ESTs 2. 28 1. 96 2. 36 416091 AF295370 Hs. 283082 defensin, beta 3 2. 28 2. 76 2. 18 418478 U38945 Hs. 1174 cyclin-dependent kinase inhibitor 2A (me 2. 27 2. 88 2. 46 427719 A1393122 Hs. 134726 ESTs 2. 27 1. 88 2. 29 431830 Y16645 Hs. 271387 small inducible cytokine subfamily A (Cy 2. 27 2. 16 4. 09 457465 AW301344 Hs. 122908 DNA replication factor 2. 26 2. 23 2. 26 431639 AK000680 Hs. 266175 phosphoprotein associated with GEMs 2. 26 2. 13 3. 16 442485 BE092285 Hs. 29724 hypothetical protein FLJ13187 2. 26 1. 75 2. 84 424687 J05070 Hs. 151738 mairixmetalioproleinase9 (gelaUnaseB 2. 26 3. 38 2. 56 449317 AW293413 Hs. 132906 19A24 protein 2. 26 2. 04 2. 73 429922 Z97630 Hs. 226117 H1 histone family, member 0 2. 26 1. 59 2. 38 441362 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re 2. 25 1. 86 3. 07 425388 AA329384 Hs. 156110 immunoglobulin kappa constant 2. 25 1. 91 2. 25 417282 AA195203 RAB5C, member RAS oncogene family 2. 25 2. 23 3. 20 406687 M31126 matrix metalloproteinase 11 (stromelysin 2. 24 2. 69 2. 78 437862 AW978107 Hs. 5884 Homo sapiens mRNA ; cDNA DKFZp586C0224 (f 2. 23 2. 20 2. 51 408015 AW136771 Hs. 244349 epidermal differentiation complex protei 2. 23 4. 59 2. 47 442503 AF147078 Hs. 150853 p53responsive gene 5 2. 23 3. 62 0. 85 429747 M87507 Hs. 2490 caspase 1, apoptosis-related cysteine pr 2. 22 1. 60 1. 69 424825 AF207069 Hs. 153357 procollagen-lysine, 2-oxoglutarate 5 dio 2. 22 5. 53 2. 46 417693 AW959741 Hs. 40368 adaptor-related protein complex 1, sigma 2. 21 2. 40 4. 37 422947 AA306782 Hs. 122552 G2 and S-phase expressed 1 2. 21 2. 06 2. 32 445875 AF070524 Hs. 13410 Homo sapiens clone 24453 mRNA sequence 2. 20 2. 69 2. 91 417366 BE185289 Hs. 1076 small proline-rich protein 1B (comifin) 2. 20 2. 26 3. 79

450065 AL050107 Hs. 24341 transenpSonal co-æUvator with PDZ-bi 2. 20 1. 96 2. 44 423397 NM 001838 Hs. 1652 chemokine (C-CmoUf) mceptor7 2. 20 3. 28 2. 99 427051 BE178110 Hs. 173374 HomosapienscDNAFUlOSOOfis, cloneNT 2. 20 1. 98 3. 40 418203 X54942 Hs. 83758 CDC28 protein kinase 2 2. 20 1. 44 2. 31 409354 N68188 Hs. 159472 HomosapienscDNA : FU22224 fis, ctone H 2. 18 Z44 2. 70 418941 AA452970 Hs. 239527 E1B-55kDa-associated protein 5 2. 18 1. 75 2. 70 424723 BE409813 Hs. 152337 protein arginine N-methyltransferase 3 (h 2. 18 1. 55 2. 44 430132 AA204686 Hs. 234149 hypothetical protein FLJ20647 2. 18 1. 43 2. 37 452194 AI694413 Ubiquitin-likeproteinFAT10 ? ? ?-diubiq 2. 17 3. 07 1. 76 417933 X02308 Hs. 82962 thymidylate synthetase 2. 17 1. 86 4. 15 420137 AA306478 Hs95327 CD3D antigen, delta polypepude (TiT3 co 2. 17 2. 38 2. 91 425317 AW205118 Hs. 210546 interleukin21 receptor 2. 17 2. 02 2. 22 447769 AW873704 Hs. 320831 Homo sapiens cDNA FLJ14597 fis, cfone NT 2. 16 1. 87 2. 49 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Grcadian Oscillat 2. 16 1. 55 2. 26 452958 AA883929 Hs. 40527 ESTs 2. 15 1. 56 2. 84 440325 Nom003812 Hs. 7164 adisintegrinandmetaloproteinasedoma 2. 15 1. 76 2. 97 426153 AF057169 Hs. 182771 vitetiiformmacu) ardystmphy (Bestdise 2. 15 1. 85 2. 74 430580 AA806105 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 2. 14 1. 88 4. 99 451952 AL120173 Hs. 301663 ESTs 2. 13 2. 08 2. 13 450534 Api570189 Hs. 25132 KIAA0470 gene product 2. 12 1. 67 3. 41 449217 AA278536 Hs. 23262 ribonuclease, RNase A family, k6 2. 12 1. 75 2. 27 432734 AA837396 Hs. 263925 LlS1-interacting protein NUDE1, rat homo 2. 12 2. 14 2. 49 413190 AA151802 Hs. 40368 adaptor-related protein complex 1, sigma 2. 12 2. 46 2. 67 443991 NM 002250 Hs. 10082 potassiumintemmediatelsmalconductan 2. 12 2. 16 2. 82 429624 AA458648 Hs. 99476 ESTs, Weakly similar to 1313184B alphal 2. 11 2. 01 0. 68 447178 AW594641 Hs. 192417 ESTs 2. 10 2. 52 2. 10 423017 AW178761 Hs. 227948 serine (or cysteine) proteinase inhibito 2. 10 1. 52 4. 01 452110 T47667 Hs. 28005 Homo sapiens cDNA FLJ11309 fis, clone PL 2. 10 1. 53 2. 10 436797 AA731491 Hs. 334477 hypothetical protein MGC14879 2. 10 1. 55 2. 41 453256 A1565587 Hs. 32556 KIAA0379 protein 2. 09 2. 13 2. 89 405547 NM018833* : Homo sapiens transporter 2, A 2. 09 2. 61 2. 09 434203 BE262677 Hs. 283558 hypothetical protein PR01855 2. 09 1. 76 4. 10 412609 Z48804 Hs. 74124 ocular albinism 1 (Netileship-Fals) 2. 09 3. 91 2. 38 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 2. 09 1. 62 1. 28 417576 AA339449 Hs. 82285 phosphoribosylglycinamide formyltransfer 2. 08 1. 86 2. 08 447377 X77343 Hs. 334334 transcription factor AP-2 alpha 2. 08 2. 83 2. 08 423198 M81933 Hs. 1634 cell division cycle 25A 2. 08 1. 66 2. 23 433068 NM 006456 Hs. 288215 sialyltransferase 2. 08 1. 94 2. 60 409038 T97490 Hs. 50002 small inducible cytokine subfamily A (Cy 2. 07 1. 91 3. 62 452392 L20815 Hs. 507 comeodesmosin 2. 07 3. 96 0. 97 403532 NM024638 : Homo sapiens hypothetical prot 2. 07 1. 88 2. 68 439859 AW292872 Hs. 124554 ESTs 2. 07 1. 72 2. 22 428484 AF104032 Hs. 184601 solute carrier famity 7 (cationicamino 2. 07 2. 26 4. 22 442643 U82756 PRP41STK/WD splicing factor 2. 07 1. 74 1. 90 426312 AF026939 Hs. 181874 interferon-induced protein with tetratri 2. 06 2. 08 1. 43 409988 N27687 Hs. 334334 transcnptionfætorAP-2alpha (æUvat 2. 06 2. 12 2. 06 408548 AA055449 Hs. 63187 ESTs, Weakty similar to ALUC NUMAN ! ! ! ! 2. 06 1. 65 2. 91 442271 AF000652 Hs. 8180 syndecan binding protein (syntenin) 2. 06 1. 97 2. 42 414142 AW368397 Hs. 334485 hemicenon (fibulin 6) 2. 05 2. 44 2. 05 420931 AF044197 Hs. 100431 small inducible cytokine B subfamily (Cy 2. 05 2. 37 2. 05 450325 A1935962 Hs. 91973 ESTs 2. 05 1. 67 1. 82 424090 X99699 Hs. 139262 XIAP associated factor-1 2. 05 1. 56 1. 99 438209 AL120659 Hs. 6111 ayl-hydrocarbonreceptornucleartransl 2. 04 1. 52 2. 07 413794 AF234532 Hs. 61638 myosin X 2. 04 2. 02 2. 11 414945 BE076358 Hs. 77667 lymphocyte antigen 6 complex, Iocus E 2. 04 4. 57 1. 64 425580 L11144 Hs. 1907 galanin 2. 04 1. 67 2. 26 420052 AA418850 Hs. 44410 ESTs 2. 03 1. 90 2. 21 415947 U04045 Hs. 78934 mutS (E. coli) homolog 2 (colon cancer, 2. 03 1. 53 2. 31 416406 D86961 Hs. 79299 lipomaHMGICfusionpartner-like2 2. 02 1. 73 2. 02 426759 A) 590401 Hs. 21213 ESTs 2. 02 1. 86 5. 47 432435 BE218886 Hs. 282070 ESTs 2. 02 1. 39 1. 67 444184 T87841 Hs. 282990 HumanDNAsequencefromcloneRP1-28H20 2. 02 1. 57 2. 02 421574 AJ000152 Hs. 105924 defensin, beta 2 2. 02 2. 22 2. 15 411358 R47479 Hs. 94761 KIAA1691 protein 2. 01 2. 55 1. 75 408209 NM 004454 Hs. 43697 ets variant gene 5 (ets-related molecule 2. 01 2. 58 2. 39 409262 AK000631 Hs. 52256 hypothetical protein FLJ20624 2. 01 1. 50 2. 01 400750 Target Exon 2. 01 1. 73 2. 09 439496 BE616501 Hs. 32343 Homosapiens SirnilartoRIKENcDNA 1110 2. 01 2. 42 0. 78 420460 AA262331 Hs. 48376 Homo sapiens clone HB-2 mRNA sequence 2. 01 1. 65 1. 72 446839 BE091926 Hs. 16244 mitoUcspindlecoiled-coilnelatedprot 2. 01 1. 61 1. 03 427647 W19744 Hs. 180059 HomosapienscDNAFLJ20653fis cloneKA 2. 00 2. 11 2. 33 436200 R51386 Hs. 124881 ESTs 2. 00 1. 89 2. 24 414175 Api308876 Hs. 103849 hypotheUcalproleinDKFZp761D112 1. 99 1. 50 1. 99 420005 AW271106 Hs. 133294 ESTs 1. 99 2. 03 2. 59 417848 M206581 Hs. 116586 ESTs WeaklysimilartoJC5314CDC28/cdc 1. 99 1. 42 2. 17 435545 AA687415 Hs. 28107 ESTs 1. 99 1. 89 1. 99 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 1. 99 2. 23 3. 44 444342 NM_014398 Hs. 10887 similar to lysosome-associated membrane 1. 99 2. 05 0. 32 453905 NM_002314 Hs. 36566 LIM domain kinase 1 1. 98 2. 48 2. 79 453884 AA355925 Hs. 36232 KIAA0186 gene product 1. 98 1. 93 1. 98 459373 BE408266 Hs. 301406 hypothetica) protein PP3501 1. 98 2. 22 1. 91 422809 AK001379 Hs. 121028 hypothetical protein FLJ10549 1. 98 1. 68 1. 98 452840 A1097393 Hs. 43481 hypothetical protein DKFZp564K192 1. 98 1. 67 2. 18

409178 BE393948 Hs. 50915 kallikrein 5 1. 98 3. 76 1. 37 420991 AW504814 Hs. 287379 HomosapiensmRNAforFLJ00111 protein, 1. 98 1. 90 2. 63 414020 NM 002984 Hs. 75703 small inducible cytokine A4 (homologous 1. 97 1. 88 1. 23 443105 X96753 Hs. 9004 chondroiün sulfate proteoglycan 4 (mela'97'95 5. 55 413450 Z99716 Hs. 75372 N-acetylgalactosaminidase, alpha-1. 97 1. 77 1. 97 431574 AW572659 Hs. 261373 hypothetical protein dJ434014. 3 1. 97 1. 73 3. 89 408561 AI308037 Hs. 84120 hypothetical protein MGC13016 1. 97 2. 89 2. 08 421866 M24470 Hs. 1435 guanosine monophosphate reductase 1. 97 1. 95 2. 65 405506 Target Exon 1. 96 1. 72 2. 27 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 1. 96 1. 74 2. 35 437379 AL359575 Hs. 23765 Homo sapiens mRNA ; cDNA DKFZp547M123 (fr 1. 95 Z09 Z77 448356 AL120837 Hs. 20993 high-glucose-regulated protein 8 1. 95 1. 66 2. 58 453931 AL121278 Hs. 25144 ESTs 1. 95 2. 38 1. 95 424308 AW975531 Hs. 154443 minichromosome maintenance deficient (S. 1. 95 1. 63 2. 82 429547 AW009166 Hs. 99376 FGENESH predicted novel secreted protein 1. 94 2. 02 1. 35 442064 A1422867 Hs. 88594 ESTs 1. 94 1. 49 2. 21 400533 ENSP00000209376' : PRED65 protein (Fragmen 1. 94 1. 69 1. 94 448752 AA593867 Hs. 300842 KIAA1608 protein 1. 94 1. 71 2. 40 408636 BE294925 Hs. 46680 CGI-12 protein 1. 94 1. 69 2. 93 439569 AW602166 Hs. 222399 CEGP1 protein 1. 93 1. 62 3. 21 405779 NM 005367 : Homo sapiens melanoma antigen. 1. 93 1. 83 1. 99 444670 H58373 Hs. 332938 hypothetical protein MGC5370 1. 93 1. 97 1. 93 446950 AA305800 Hs. 5672 hypothetical protein AF140225 1. 93 1. 56 1. 61 409185 AW961601 Hs. 252406 hypothetical protein FU12296 similarto 1. 93 2. 12 2. 63 409098 AA132672 Hs. 7984 pleckstrin homoiogy, Sec7 anú coiled/coi 1. 92 2. 12 2. 51 413916 N49813 Hs. 75615 apolipopnot inC-II 1. 92 1. 98 0. 22 429609 AF002246 Hs. 210863 cell adhesion molecule with homology to 1. 92 1. 65 6. 39 402994 NM002463' : Homo sapiens myxovirus (indu 1. 92 2. 45 1. 89 425722 A1659076 Hs. 97031 hypothetical protein MGC13047 1. 92 2. 69 2. 30 421958 AA357185 Hs. 109918 ras homolog gene family, member H 1. 92 2. 10 2. 93 412584 X54870 Hs. 74085 DNA segment on chromosome 12 (unique) 24 1. 91 1. 57 1. 91 415402 AA164687 Hs. 177576 mannosyl (alpha-1, 3-) slycopnotein beta-1. 91 1. 44 1. 68 430280 AA361258 Hs. 237868 intedeukin 7 receptor 1. 90 1. 52 1. 14 426251 M24283 Hs. 168383 intercellular adhesion molecule 1 (CD54) 1. 90 2. 16 1. 21 440773 AA352702 Hs. 37747 Homo sapiens, Similar to RIKEN cDNA 2700 1. 90 1. 84 2. 07 427923 AW274357 Hs. 301406 hypothetical protein PP3501 1. 90 4. 26 1. 70 426470 AA528794 Hs. 128644 ESTs 1. 90 2. 69 2. 04 409557 BE182896 Hs. 3686 ESTs 1. 90 2. 01 1. 90 429714 BE561801 Hs. 2484 T-cell leukemiaaymphoma IA 1. 90 2. 49 2. 52 428125 AA393071 Hs. 182579 bucine aminopepùdae 1. 89 1. 89 1. 49 427634 Api399745 Hs. 18449 hypothetical protein MGC10820 1. 89 3. 59 1. 71 452874 AK001061 Hs. 30925 hypotheUical protein FLJ10199 1. 89 1. 67 1. 45 418883 BE387036 Hs. 1211 acid phosphatase 5, tartrate resistant 1. 89 2. 55 1. 39 448243 AW369771 integrin, beta 8 1. 89 1. 96 1. 89 416114 AI695549 Hs. 183868 glucuronidase, beta 1. 89 1. 70 1. 10 425935 Z98200 Hs. 163724 HSPC019 protein 1. 88 1. 86 2. 04 440672 AF083811 Hs. 7345 MAD1 (mitoticarrestdeficient, yeat, h 1. 88 4. 16 1. 78 430171 AF086289 Hs. 234766 skin-specific protein 1. 87 2. 70 0. 75 407366 AF026942 Hs. 17518 gb : Homo sapiens cig33 MRNA, partal sequ 1. 87 2. 25 1. 87 454294 AB000734 Hs. 50640 JAK binding protein 1. 87 1. 98 1. 46 417370 T28651 Hs. 82030 tryptophanyl-tRNA synthetase 1. 87 2. 73 1. 71 409417 AA156247 Hs. 104879 senne (or cysteine) proteinase inhibito 1. 87 1. 79 2. 72 401781 Target Exon 1. 87 1. 88 1. 16 440590 Al863446 Hs. 266308 mosaic serine protease 1. 86 1. 79 1. 13 428450 NM 014791 Hs. 184339 KIAA0175 gene product 1. 86 1. 72 4. 39 433675 AW977653 Hs. 75319 nbonucleotide reductase M2 polypeptide 1. 86 1. 81 1. 86 429323 NM 001649 Hs. 2391 apical protein, Xenopus laevis-like 1. 86 1. 57 1. 86 433001 AF217513 Hs. 279905 clone HCiO310 PR00310pl 1. 85 1. 71 5. 82 453107 NM_016113 Hs. 279746 vanilloid receptor-like protein 1 1. 85 2. 75 1. 84 430441 BE398091 desmoplakin (DPI, DPII) 1. 85 1. 80 2. 79 417512 X76534 Hs. 82226 glycoprotein (transmembrane) nmb 1. 85 1. 80 1. 86 423673 BE003054 Hs. 1695 matrix metaloproteinae 12 (macrophage 1. 85 1. 94 1. 85 431958 X63629 Hs. 2877 cadherin 3, type 1, Pcadherin (ptacenta 1. 85 1. 72 2. 52 414737 A1160386 Hs. 125087 ESTs 1. 84 1. 90 1. 84 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 1. 84 1. 57 1. 84 428311 NM 005651 Hs. 183671 tryptophan 2, 3-dioxygenase 1. 84 1. 41 0. 12 412141 Al183838 Hs. 48938 hypothetical protein FW21802 1. 84 1. 70 3. 15 428515 AF030339 Hs. 286229 plexin C1 1. 84 1. 66 1. 84 427914 AA417350 Hs. 20575 ESTs 1. 84 2. 32 2. 17 439352 BE614347 Hs. 169615 hypothetical protein FLJ20989 1. 84 1. 55 1. 84 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa 1. 83 3. 20 1. 75 435080 Api831760 Hs. 155111 hypothetical protein FLJ14428 1. 83 1. 62 1. 47 407966 AA295052 Hs. 38516 Homo sapiens, clone MGC : 15887, mRNA, com 1. 83 1. 58 2. 11 421535 AB002359 Hs. 105478 phosphoribosylformylglycinamidine syntha 1. 83 1. 73 2. 18 433029 NM_014322 Hs. 279926 opsin 3 (encephalopsin) 1. 83 1. 96 1. 83 426158 NM001982 Hs. 199067 v-erb-b2 avian erythroblastic leukemia v 1. 83 1. 61 2. 46 426890 AA393167 Hs. 41294 ESTs 1. 82 2. 44 1. 82 411027 AF072099 Hs. 67846 leukocyte immunoglobulin-like receptor, 1. 82 2. 24 2. 01 441859 AW194364 Hs. 94814 ESTs, Weakly similar to FIG1 MOUSE FIG-1 1. 82 2. 72 2. 16 437435 AA249439 Hs. 27027 hypothetical protein DKFZp762H1311 1. 82 1. 50 1. 82 448357 N20169 Hs. 108923 RAB38, member RAS oncogene family 1. 82 2. 52 1. 76 420674 NM_000055 Hs. 1327 butyrylcholinesterae 1. 82 1. 43 0. 68 439219 N33883 Hs. 41322 ESTs 1. 82 1. 88 2. 43

432810 AA863400 ESTs 1. 82 1. 43 1. 82 417404 NM 007350 Hs. 82101 plecksthn homology-like domain, family 1. 82 1. 98 1. 82 447484 AA464839 Hs. 292566 hypothetical protein FLJ14697 1. 82 1. 63 1. 82 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 1. 82 2. 80 2. 18 418918 X07871 Hs. 89476 CD2 antigen (p50), sheep red blood cell 1. 82 2. 28 2. 00 424755 AB033094 Hs. 152925 KtAA1268 protein 1. 82 1. 85 1. 62 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 1. 82 1. 74 5. 18 420783 A1659838 Hs. 99923 lecGn, galactoside-binding, soluble, 7 1. 81 1. 87 0. 80 417105 X60992 Hs. 81226 CD6 antigen 1. 81 1. 88 2. 03 423961 D13666 Hs. 136348 periostin (OSP-2os) 1. 81 1. 73 2. 45 446019 Al362520 histonedeæetylae3 1. 81 1. 39 2. 24 412580 AA113262 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 1. 81 3. 05 1. 58 409415 AA579258 Hs. 6083 Homo sapiens cDNA : FU21028 fis, clone C 1. 80 2. 00 1. 78 453684 AK001922 Hs. 34578 alpha2, 3-sialyltransferase 1. 80 1. 98 1. 22 446921 A8012113 Hs. 16530 small inducible cytokine subfamily A (Cy 1. 80 1. 56 1. 71 453779 N35187 Hs. 43388 28kD interferon responsive protein 1. 80 2. 42 2. 04 434706 A1656291 Hs. 116394 ESTs 1. 80 1. 58 1. 80 416065 BE267931 Hs. 78996 proliferating cell nuclear antigen 1. 80 1. 79 2. 51 453331 Api240665 ESTs 1. 79 1. 43 2. 33 429412 Nom006235 Hs. 2407 POU domain, class 2, associating factor 1. 79 1. 46 4. 46 428784 Y12851 Hs. 193470 purinengicreceptorP2X, ligand-gatedio 1. 79 2. 30 1. 79 453507 AF083217 Hs. 33085 WD repeat domain 3 1. 79 1. 49 1. 51 452826 BE245286 Hs. 301636 peroxisomal biogenesis factor 6 1. 79 1. 57 2. 00 439237 AW408158 Hs. 318893 ESTs, Weakly similar to A47582 B-cell gr 1. 79 2. 26 2. 22 406672 M26041 Hs. 198253 major histocompatibility complex, class 1. 79 1. 76 1. 78 431009 BE149762 Hs. 48956 gap junction protein, beta 6 (connexin 3 1. 79 1. 43 3. 32 452698 NM 001295 Hs. 301921 chemokine (C-Cmoüf) receptor1 1. 78 1. 66 1. 29 424954 NM000546 Hs. 1846 tumor protein p53 (U-Fraumeni syndrome) 1. 78 1. 73 2. 35 436378 AJ227874 Hs. 99244 ESTs 1. 78 1. 84 1. 78 421778 AA428000 Hs. 283072 actin related protein 2/3 complex, subun 1. 78 1. 66 3. 67 421948 L42583 Hs. 334309 keratin 6A 1. 78 1. 74 3. 00 414915 NM002462 Hs. 76391 myxovirus (influenza) resistance 1, homo 1. 77 2. 27 2. 13 437317 AA748613 Hs. 311977 ESTs, Highly similar to SWI/SNF related, 1. 77 1. 98 2. 32 427318 AF186081 Hs. 175783 zinc transporter 1. 77 1. 61 0. 92 418403 D86978 Hs. 84790 KIAA0225 protein 1. 76 1. 49 2. 24 421433 Al829192 Hs. 22380 ESTs 1. 76 1. 49 2. 52 450728 AW162923 Hs. 25363 presenilin 2 (Alzheimer disease 4) 1. 76 1. 74 1. 76 428655 H05769 Hs. 188757 Homo sapiens, clone MGC : 5564, mRNA, comp 1. 76 1. 43 1. 76 427536 BE277141 Hs. 115803 gb : 601178666F1 NlH_MGC_20Homosapiensc 1. 76 2. 12 1. 76 433364 A1075407 Hs. 296083 ESTs, Moderately similar to 154374 gene 1. 76 1. 86 1. 48 401994 Target Exon 1. 75 1. 44 1. 75 418299 AA279530 Hs. 83968 integnn, beta 2 (antigen CD18 (p95), ly 1. 75 1. 69 1. 79 408633 AW963372 Hs. 46677 PR02000 protein 1. 75 1. 46 1. 88 429978 AA249027 ribosome protein S6 1. 75 1. 60 1. 92 450690 AA296696 Hs. 333418 FXYD domain-containing ion transport reg 1. 75 2. 13 2. 03 456967 AW004056 Hs. 168357 T-box 2 1. 74 1. 95 1. 42 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 1. 74 2. 64 2. 01 428746 AW503820 Hs. 192861 Spi-B transcription factor (Spi-1/PU. 1r 1. 74 2. 82 2. 31 432642 BE297635 Hs. 3069 heat shock 70kD protein 9B (mortalin-2) 1. 74 1. 51 1. 62 429505 AW820035 Hs. 278679 a disintegrin and metalloproteinase doma 1. 73 1. 54 3. 15 412851 A1826502 Hs. 97269 ESTs 1. 73 1. 67 1. 05 453953 AW408337 Hs. 36972 CD7 antigen (p41) 1. 73 2. 22 2. 28 430413 AW842182 Hs. 241392 small inducible cytokine A5 (RANTES) 1. 73 2. 05 1. 47 419485 AA489023 Hs. 99807 ESTs Weakly similar to unnamed protein 1. 73 1. 71 1. 73 447217 BE465754 Hs. 17778 neuropilin 2 1. 73 1. 62 4. 70 437673 AW665665 Hs. 153034 ESTs 1. 72 1. 55 2. 10 437879 BE262082 Hs. 5894 hypothetical protein FU10305 1. 72 2. 50 1. 80 448410 AK000227 Hs. 21126 hypothetical protein FU20220 1. 72 1. 48 3. 98 413313 NM002047 Hs. 283108 glycyl-tRNA synthetase 1. 72 2. 19 1. 82 452203 X57522 transporter 1, ATP-binding casette, sub 1. 72 2. 68 1. 68 443950 NM_001425 Hs. 9999 epithelial membrane protein 3 1. 71 2. 17 2. 24 403969 ENSP00000034663 : Zinc finger protein 131 1. 71 1. 31 1. 71 450832 AW970602 Hs. 105421 ESTs 1. 71 1. 33 2. 38 453005 AW055308 Hs. 31803 ESTs, Weakly similar to N-WASP [H. sapien 1. 71 1. 67 1. 95 439783 Api125760 Hs. 24835 hypothetical protein FLJ 14594 1. 71 2. 10 2. 20 418678 NM 001327 Hs. 167379 cancer/testis antigen (NY-ESO-1) 1. 71 3. 86 1. 76 432259 BE269103 Hs. 274201 60S acidic ribosome protein PO 1. 71 1. 85 1. 94 420340 NM 000734 Hs. 97087 CD3 antigen, zeta polypep6de (TiT3 com 1. 71 2. 12 1. 98 428289 M26301 Hs. 2253 complement component 2 1. 71 2. 46 0. 76 424006 AF054815 Hs. 137548 CD84 antigen (leukocyte antigen) 1. 70 1. 70 2. 78 440039 Z46188 Hs. 6874 KIAA0472 protein 1. 70 2. 24 1. 60 406646 M33600 Hs. 308026 major histocompatibility complex, class 1. 70 2. 27 1. 33 425367 BE271188 Hs. 155975 protein tyrosine phosphatase, receptor t 1. 70 2. 77 2. 07 420286 A1796395 Hs. 111377 ESTs 1. 70 1. 50 3. 21 430255 AK000703 Hs. 323822 Homo sapiens mRNA for KIAA1551 protein, 1. 69 1. 44 1. 69 445247 AW274290 Hs. 153997 ESTs 1. 69 2. 57 1. 65 436965 Z11894 Hs. 156110 gb : H. sapiens rearranged mRNAforimmunog 1. 69 1. 52 3. 13 410257 BE244044 Hs. 61469 hypothetical protein 1. 69 1. 99 1. 97 424663 NM002351 Hs. 151544 SH2 domain protein 1A, Duncan's disease 1. 69 1. 76 1. 69 427792 M63928 Hs. 180841 tumor necrosis factor receptor superfami 1. 69 1. 98 2. 48 458098 BE550224 metallothionein 1E (functional) 1. 68 1. 83 1. 68 425397 J04088 Hs. 156346 topoisomerase (DNA) ! ! alpha (170kD) 1. 68 1. 57 4. 09 421485 AA243499 Hs. 104800 hypothetical protein FUI0134 1. 68 1. 64 0. 68

421563 NM 006433 Hslo5806 granulysin 1. 68 2. 24 1. 55 448775 A8025237 Hs. 388 nudix (nucleosidediphosphatelinked moi 1. 68 1. 98 2. 05 451418 BE387790 Hs. 26369 hypothetical protein FLJ20287 1. 68 1. 35 1. 68 440457 BE387593 Hs. 21321 HomosapienscloneFLB9213PR02474mRNA, 1. 68 1. 88 1. 63 438866 U44385 Hs. 325495 bssue inhibilor of metalloproteinase 2 1. 67 2. 54 1. 90 401760 Target Exon 1. 67 1. 93 1. 61 422158 L10343 Hs. 112341 protease inhibitor 3, skin-derived (SKAL 1. 67 1. 85 4. 25 446644 NM 003272 Hs. 15791 tmnsmembrane 7 superfamify member I (up 1. 67 1. 94 1. 48 415701 NM 003878 Hs. 78619 gamma-glutamyl hydrolase (conjugase, fol 1. 67 1. 65 0. 90 450293 N36754 Hs. 171118 hypothetical protein FLJ00026 1. 67 1. 54 1. 95 412856 BE386745 Hs. 74631 basigin (OK blood group) 1. 67 2. 71 1. 47 439318 AW837046 Hs. 6527 G protein-coupled receptor 56 1. 66 1. 82 1. 19 424399 AI905687 AI905687 : IL-8T095-19D190198T095Homo 1. 66 3. 65 0. 44 432355 AA534416 Hs. 162185 ESTs, Weakly similar to S42799 garp prec 1. 66 1. 98 1. 45 427239 BE270447 ubiquitin carrier protein 1. 66 2. 94 1. 92 425262 D87119 Hs. 155418 GS3955 protein 1. 66 2. 36 1. 66 413869 NM 000878 Hs. 75596 interleukin 2 receptor, beta 1. 66 1. 86 1. 90 406698 X03068 Hs. 73931 major histocompaibility complex, class 1. 65 2. 05 1. 31 446217 A1651594 Hs. 99709 ESTs 1. 65 1. 98 1. 77 400222 NM002082* : Homo sapiens G protein-couple 1. 65 1. 74 1. 81 432468 AW402155 Hs. 3003 CD3E antigen, epsilon polypeptide (TiT3 1. 65 2. 50 1. 77 417237 H86385 Hs. 81737 palmitoyl-protein thioesterase 2 1. 65 2. 89 1. 57 433012 NM_004045 Hs. 279910 ATX1 (antioxidant protein 1. yeast) homo 1. 64 2. 76 1. 26 446291 BE397753 Hs. 14623 interferon. gamma-inducible protein 30 1. 64 1. 96 1. 24 433867 AK000596 Hs. 3618 hippocatcin-like 1 1. 64 1. 47 1. 00 433671 AW138797 Hs. 132906 19A24 protein 1. 64 Z17 1. 96 418371 M13560 Hs. 84298 CD74 antigen (invariant polypeptide of m 1. 64 2. 18 1. 43 432336 NM 002759 Hs. 274382 protein kinase, interferon-inducible dou 1. 64 1. 47 1. 64 409264 NM014937 Hs. 52463 KIAA0966 protein 1. 64 1. 46 4. 89 431836 AF178532 Hs. 271411 beta-site APPcleaving enzyme 2 1. 64 2. 58 1. 79 414586 AA306160 Hs. 16488 lymphocyte cytosolic protein 1 (L-plasb 1. 63 1. 72 1. 88 418117 Api922013 Hs. 83496 linker for activation of T cells 1. 63 1. 98 1. 99 448304 BE622768 Hs. 290356 mesoderm development candidate 1 1. 63 1. 67 1. 86 425535 AB007937 Hs. 158287 KIM0468 gene product 1. 63 2. 56 1. 97 453258 AW293134 Hs. 32597 ring finger protein (C3H2C3 type) 6 1. 63 1. 46 2. 43 420000 AB036063 Hs. 94262 p534nducibie ribonucleoUde reductase s 1. 63 1. 34 1. 94 447321 AW271217 Hs. 281434 Homo sapiens cDNAFU14028fis, clone HE 1. 63 1. 96 1. 77 422192 AA305159 Hs. 113019 fls485 1. 62 1. 45 1. 62 450701 H39960 Hs. 288467 hypothetical protein XP_098151 (leucine-1. 62 2. 23 1. 53 419381 AB023420 Hs. 90093 heat shock 70kD protein 4 1. 62 1. 57 2. 38 424779 AL046851 Hs. 153053 CD37 antigen 1. 62 1. 92 2. 10 413283 R78669 Hs. 23756 hypothetical protein similar to swine ac 1. 62 1. 41 1. 12 414907 X90725 Hs. 77597 polo (Drosophia)-like kinase 1. 62 2. 03 2. 13 414159 AW511414 Hs. 257352 apolipoproteinL, 6 1. 62 1. 89 1. 32 410055 AJ250839 Hs. 58241 geneforsenneRhreonineproteinkinae 1. 62 1. 81 1. 27 428179 A1127772 Hs. 279696 serunvglucocortcoid regulated kinase-li 1. 62 1. 50 2. 13 436251 BE515065 Hs. 296585 nucleolar protein (KKE/D repeal) 1. 61 1. 71 2. 02 451708 Api306536 Hs. 60975 ESTs 1. 61 2. 31 1. 70 418113 AI272141 Hs. 83484 SRY (sex determining region Y)-box 4 1. 61 1. 53 2. 50 410600 AW575742 ESTs, Moderately similar to S65657 alpha 1. 61 1. 83 1. 69 436873 N23874 Hs. 50477 RAB27A, member RAS oncogene family 1. 61 1. 56 1. 61 440201 AL359588 Hs. 7041 hypothetical protein DKFZp762B226 1. 61 1. 58 1. 85 414368 W70171 Hs. 75939 uridine monophosphate kinase 1. 61 1. 59 2. 75 454429 BE273437 Hs. 301406 hypothefical protein PP3501 1. 61 3. 54 1. 52 422257 NM_001716 Hs. 113916 Burkitlymphomareceptor1, GTP-binding 1. 61 2. 15 1. 54 426437 BE076537 Hs. 169895 ubiquiUn40njugaUngenzymeE2L6 1. 60 2. 01 1. 36 408826 AF216077 Hs. 48376 HomosapienscloneHB-2mRNAsequence 1. 60 2. 00 1. 60 414761 AU077228 Hs. 77256 enhancerofzeste (Drosophila) homolog2 1. 60 1. 38 2. 23 429612 AF062649 Hs. 252587 pituitary tumor-transforming 1 1. 60 1. 78 2. 59 411263 BE297802 Hs. 69360 kinesin-like6 (mitoUccentnomere-asoc 1. 60 1. 78 2. 07 417324 AW265494 ESTs 1. 60 2. 48 1. 91 430325 AF004562 Hs. 239356 syntaxin binding protein 1 1. 60 1. 74 2. 53 431797 BE169641 Hs. 270134 hypotheticalproteinFlJ20280 1. 60 1. 46 2. 46 434449 AW953484 Hs. 3849 hypothetical protein FU22041 similar to 1. 60 1. 81 3. 00 443378 AW392550 Hs. 9280 proteasome (prosome, macropain) subunit, 1. 59 1. 88 1. 68 417437 U52682 Hs. 82132 interferon regulatory factor 4 1. 59 1. 90 2. 26 437949 U78519 Hs. 41654 ESTs, Weakly similar to A46010 X-linked 1. 59 2. 14 1. 59 401797 Target Exon 1. 59 1. 82 1. 78 449720 AA311152 Hs. 288708 hypothetical protein FU21562 1. 59 1. 45 4. 69 424971 AA479005 Hs. 154036 tumor suppressing subtransferable candid 1. 59 1. 82 1. 68 415474 NM 014252 Hs. 78457 solutecarierfamily25 (mitochondria 1. 58 1. 51 0. 30 430017 AA263172 Hs. 35 protein tyrosine phosphatase, non-recept 1. 58 1. 72 2. 46 422515 AW500470 Hs. 117950 mulühuncUonåpolypepUdesimilatoS 1. 58 1. 85 1. 94 434094 AA305599 Hs. 238205 hypothetical protein PR02013 1. 58 1. 25 2. 09 428844 AW972635 Hs. 301904 hypothetical protein FLJ12671 1. 58 1. 72 1. 80 440942 AW246547 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 1. 58 2. 60 1. 58 419596 BE379320 Hs. 91448 MKP-1 like protein tyrosine phosphatase 1. 58 1. 84 1. 22 401151 Target Exon 1. 58 2. 43 1. 60 441590 Al623207 Hs. 190537 ESTs 1. 58 1. 40 1. 58 418677 S83308 Hs. 87224 SRY (sex determining region Y)-box 5 1. 58 1. 68 1. 58 416448 L13210 Hs. 79339 lectin, gaaCoside-binding, soluble, 3 1. 58 2. 28 1. 60 418739 AA310964 Hs. 88012 SHP2 interacting transmembrane adaptor 1. 58 2. 14 2. 10 418216 AA662240 Hs. 283099 AF15q14 protein 1. 57 1. 46 1. 57

427700 AA262294 Hs. 180383 dual specificity phosphatase 6 1. 57 1. 42 0. 88 436485 X59135 Hs. 156110 immunoglobulin kappa constant 1. 57 1. 49 2. 69 404872 ENSP00000243173' : DJ1109J22. 1 (novel home 1. 57 1. 46 1. 36 408212 AA297567 Hs. 43728 hypothetical protein 1. 57 1. 55 2. 73 414699 A1815523 Hs. 76930 synuclein, alpha (non A4 component of am 1. 57 1. 36 1. 57 444006 BE395085 Hs. 10086 type I transmembrane protein Fnl4 1. 57 1. 70 1. 13 432946 U60899 Hs. 279854 mannosidase, alpha, class 28, member 1 1. 57 1. 75 1. 57 417929 R27219 Hs. 74647 Human T-cell receptor active alpha-chain 1. 57 2. 26 2. 10 431629 AU077025 Hs. 265827 interferon, alpha-inducible protein (clo 1. 57 2. 09 1. 57 402876 NM 022161' : Homo sapiens livin inhibitor-1. 56 2. 28 1. 45 439627 BE621702 Hs. 29076 hypothetical protein FU21841 1. 56 2. 97 1. 54 414839 X63692 Hs. 77462 DNA (cytosine-5-)-methyltrans/erase 1'. 56 1. 75 1. 88 450663 H43540 Hs. 25292 ribonucleae Hl, large subunit 1. 56 2. 76 1. 67 425818 AB021225 Hs. 159581 matdx metalloproteinase 17 (membrane-in 1. 56 2. 36 1. 83 422765 AW409701 Hs. 1578 baculovirat IAP repeat-containing 5 (sur 1. 56 1. 78 Z06 456508 AA502764 Hs. 123469 ESTs, WeaklysimilartoAF2088551BM-01 1. 56 1. 32 2. 70 453613 F06838 ESTs 1. 56 1. 76 1. 84 428379 X06026 Hs. 2259 CD3G antigen, gamma polypepUde (TiT3 co 1. 56 1. 43 1. 56 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactin) 1. 56 1. 47 3. 15 444652 BE513613 Hs. 11538 acon related protein 2/3 complex. subun 1. 56 2. 01 1. 56 420842 A1083668 Hs. 50601 hypothetica) protein MGC10986 1. 55 2. 24 1. 90 447513 AW955776 Hs. 313500 ESTs, Moderately similar to ALU7 HUMAN A 1. 55 1. 24 3. 07 408901 AK001330 Hs. 48855 hypothetical protein FU10468 1. 55 1. 79 2. 17 437669 Al358105 Hs. 123164 ESTs, Weakly similar to match to ESTs AA 1. 55 1. 83 1. 96 439437 A1207788 Hs. 343628 sialyltransferase 4B (beta-galactosidase 1. 55 1. 63 2. 20 418835 AL023694 Hs. 88977 hypotheUcalproteindJSllE16. 2 1. 55 1. 73 1. 50 448633 AA311426 Hs. 21635 tubulin, gamma 1 1. 54 2. 02 1. 67 447763 BE619911 Hs. 115803 hypothetical protein 1. 54 2. 52 1. 52 430223 NM 002514 Hs. 235935 nephroblastoma overexpressed gene 1. 54 1. 54 3. 03 448258 BE386983 Hs. 343214 hypothetical protein FLJ20396 1. 54 1. 97 1. 53 440165 AW014718 Hs. 7753 calumenin 1. 54 1. 53 2. 55 433376 Al249361 Hs. 74122 caspase 4, apoptosis-related cysteine pr 1. 54 1. 34 1. 69 445982 BE410233 Hs. 13501 pescadillo (zebrafish) homolog 1, contai 1. 54 2. 21 1. 54 419741 NM 007019 Hs. 93002 ubiquitin carrier protein E2-C 1. 54 2. 50 1. 94 416926 H03109 Hs. 263395 HT018protein 1. 54 1. 41 2. 01 431630 NM002204 Hs. 265829 integrin, alpha 3 (antigen CD49C, alpha 1. 54 1. 89 1. 23 442159 AW163390 Hs. 278554 heterochromatin-like protein 1 1. 54 1. 93 1. 79 420421 AF281133 Hs. 343589 exosomecomponentRrp41 1. 53 2. 47 1. 61 406973 M34996 Hs. 198253 major histocompatibility complex, class 1. 53 1. 62 1. 19 422530 AW972300 Hs. 118110 bonemanowstromalcellantigen2 1. 53 1. 74 1. 37 423420 Api571364 Hs. 128382 HomosapiensmRNA ; cDNADKFZp76111224 (f 1. 53 2. 49 1. 59 429359 W00482 Hs. 2399 matrix metafloproteinase 14 (membrane-in 1. 53 2. 72 1. 54 429837 NM003896 Hs. 225939 sialyhransferae 9 (CMP-NeuAc : lactosylc 1. 53 1. 64 2. 40 412939 AW411491 Hs. 75069 eukaryotic translation elongation factor 1. 52 1. 98 0. 98 410678 BE540516 Hs. 293732 hypothetical protein MGC3195 1. 52 1. 39 2. 17 431186 NM012249 Hs. 250697 ras-like protein 1. 52 1. 91 1. 82 406868 AA505445 Hs. 300697 immunoglobutin heavy constant gamma 3 (G 1. 52 1. 57 1. 82 422532 AL008726 Hs. 118126 protective protein for beta-galactosidas 1. 51 2. 08 1. 19 413063 AL035737 Hs. 75184 chitnase 3 like 1 (carülage glycoprote 1. 51 1. 50 0. 67 417308 H60720 Hs. 81892 Kit0101 gene product 1. 51 1. 42 7. 41 424902 NM_003866 Hs. 153687 inositol polyphosphate-4-phosphatase, ty 1. 51 2. 75 1. 51 405204 NM 002086" : Homo sapiens growth factor re 1. 51 1. 44 1. 53 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 1. 51 1. 92 2. 32 422516 BE258862 Hs, 117950 mulUfuncUonalpolypeptidesimilartoS 1. 50 1. 61 1. 47 418827 BE327311 Hs. 47166 HT021 1. 50 1. 35 3. 53 427550 BE242818 Hs. 311609 nuclearRNAhelicase, DECDvanantotDE 1. 50 1. 55 2. 09 432992 BE270472 Hs. 279900 HSPC015 protein 1. 50 1. 82 0. 82 442432 BE093589 Hs. 38178 hypothetical protein FLJ23468 1. 50 1. 34 4. 87 413566 AW604451 Hs. 285814 sprouty (Drosophila) homolog 4 1. 50 3. 05 1. 51 422616 BE300330 Hs. 118725 selenophosphate synthetase 2 1. 50 1. 36 0. 46 431222 X56777 Hs. 273790 zona pellucida glycoprotein 3A (sperm re 1. 50 2. 05 1. 78 421861 S78798 Hs. 108966 phosphatidylinositol-4-phosphate 5-kinas 1. 49 1. 52 2. 62 422684 BE561617 Hs. 119192 HZAhistonefamily, memberZ 1. 49 1. 53 2. 02 452363 A1582743 Hs. 94953 Homo sapiens, Similar to complement comp 1. 49 2. 02 1. 41 411825 AK000334 hypothetical protein FLJ20327 1. 49 2. 55 1. 38 409425 U40462 Hs. 54452 zinc finger protein, subfamily 1A, 1 (Ik 1. 49 1. 77 1. 49 431070 AW408164 Hs. 249184 transcription factor 19 (SC1) 1. 49 1. 79 1. 75 427080 AW068287 Hs. 301175 ras-related C3 botulinum toxin substrate 1. 49 1. 57 2. 14 440676 NM004987 Hs. 112378 LIM and senescent cell antigen-like doma 1. 49 1. 42 1. 46 411296 BE207307 Hs. 10114 growth suppressorl 1. 49 1. 74 1. 50 442894 W02112 Hs. 8836 parvin, beta 1. 49 2. 25 1. 51 416361 AW204907 Hs. 6872 ESTs, Weakly similar to CA13 HUMAN COLLA 1. 49 2. 06 1. 89 424162 AA336229 Hs. 93135 ESTs, Weakly similar to ALU2 HUMAN ALU S 1. 49 1. 59 1. 65 447131 NM 004585 Hs. 17466 retinoic acid receptor responder (tazaro 1. 49 2. 00 1. 22 427759 BE245578 Hs. 2200 perform 1 (pore forming protein) 1. 49 2. 12 1. 41 422846 BE513934 Hs. 1583 neutrophilcytosolicfætor1 (47hD, chr 1. 49 1. 61 1. 67 417007 AF224741 Hs. 80768 chloride channel 7 1. 48 1. 94 1. 71 421924 BE514514 Hs. 109606 coronin, acfin-binding protein, 1A 1. 48 1. 68 1. 67 422241 Y00062 Hs. 170121 protein tyrosine phosphatase, receptor t 1. 48 1. 43 2. 25 410741 Z11695 Hs. 324473 mitogen-activated protein kinaset 1. 48 1. 37 3. 17 447471 AF039843 Hs. 18676 sprouty (Drosophila) homolog 2 1. 48 1. 35 1. 46 427247 AW504221 Hs. 174103 integrin, alphaL (antigenCD11A (p180), 1. 47 1. 58 1. 48 442945 A1024849 Hs. 131853 ESTs 1. 47 1. 73 1. 38

447200 BE543146 Hs. 281434 Homo sapiens cDNA FW 14028 fis, clone HE 1. 47 1. 89 1. 60 424085 NM 002914 Hs. 139226 replication factor C (activator t) 2 (40 1. 47 2. 03 1. 47 422867 L32137 Hs. 1584 cartilage otigomenc matrix protein (pse 1. 47 1. 86 1. 93 416350 AF188625 Hs. 189507 phospholipase A2, group IID 1. 47 2. 92 1. 49 458207 T28472 Hs. 7655 U2 nudearribonudeoproteinauxi) 1. 47 1. 61 1. 73 447940 D86982 Hs. 20060 KIAA0229 protein 1. 47 1. 93 1. 72 446t06 AA377165 Hs. 44833 ESTs 1. 47 1. 56 1. 63 425811 AL039104 Hs. 159557 karyophennalpha2 (RAGcohort1, impor 1. 47 1. 78 1. 84 432615 AA557191 Hs. 55028 ESTs, Weakly similar to 154374 gene NF2 1. 47 2. 04 1. 47 435099 AC004770 Hs. 4756 ftapstructure-specificendonudeaset 1. 47 1. 76 1. 83 402294 Target Exon 1. 47 1. 27 1. 46 430147 R60704 Hs. 234434 hairy/enhancer-of-split related with YRP 1. 46 2. 00 1. 59 414324 Y14768 Hs. 890 lymphotoxin beta (TNF superfamily, membe 1. 46 1. 58 2. 15 400270 NM_000026' : Homo sapiens adenyWosuccinate 1. 46 1. 42 2. 32 414806 D14694 Hs. 77329 phosphabdylserine synthae 1 1. 46 2. 07 1. 40 419625 U91616 Hs. 182885 nuclear factor of kappa light polypepbd 1. 45 1. 78 1. 53 430594 AK000790 Hs. 246885 hypothetical protein FLJ20783 1. 45 1. 31 0. 90 419556 U29615 Hs. 91093 chitinase 1 (chitotriosidase) 1. 45 2. 13 1. 46 453350 Api917771 Hs. 61790 hypothetical protein FU23338 1. 45 2. 00 1. 39 448412 AI219083 Hs. 42532 ESTs, Moderately similar to ALU8_HUMAN A 1. 45 1. 37 3. 17 411619 Api418609 Hs. 71040 hypothetical protein FLJ20425 1. 45 1. 39 3. 01 424218 AF031824 Hs. 143212 cystatinF (leukocystatin) 1. 45 1. 82 1. 44 450395 BE048545 Hs. 161757 ESTs 1. 45 2. 40 1. 33 438555 Api222089 Hs. 143878 HomosapiensmRNAforFU00024protein, 1. 45 1. 91 1. 65 422497 D29642 Hs. 1528 KIAA0053 gene product 1. 45 1. 94 1. 49 400991 Target Exon 1. 45 2. 10 1. 42 431779 AW971178 Hs. 268571 apolipoprotein ! 1. 45 1. 53 0. 42 424618 L29472 Hs. 1802 majorhistocompaUbilitycomplex, clas 1. 44 1. 96 1. 86 423032 Al684746 Hs. 119274 RASp21proteinæUvator (GrPaseæüva 1. 44 1. 34 3. 36 424232 AB015982 Hs. 143460 protein kinase C, nu 1. 44 1. 28 2. 94 438291 BE514605 Hs. 289092 HomosapienscDNA : FLJ22380 fis, clone H 1. 44 1. 63 1. 45 445745 AB007924 Hs. 13245 KlM0455geneproduct 1. 44 1. 17 1. 52 449209 BE616830 Hs. 294145 ESTs 1. 44 1. 35 2. 48 410129 BE244074 Hs. 58831 regulator of Fas-induced apoptosis 1. 44 2. 10 1. 79 401284 Target Exon 1. 44 1, 71 1. 44 422675 BE018517 Hs. 119140 eukaryotictranstation initiation factor 1. 44 1. 68 1. 45 433020 A1375726 Hs. 279918 hypothetical protein 1. 44 1. 37 2. 02 420042 AW015140 Hs. 161723 ESTs 1. 44 2. 02 1. 29 453878 AW964440 Hs. 19025 DC32 1. 44 1. 69 1. 44 427268 X78520 Hs. 174139 chloride channel 3 1. 44 1. 45 1. 96 417386 AL037228 Hs. 82043 D123 gene product 1. 43 1. 32 2. 81 409197 N54706 Hs. 303025 chromosome 11 open reading frame 24 1. 43 1. 80 1. 17 411009 W37572 Hs. 285864 ESTs 1. 43 1. 57 1. 72 433160 AW207002 Hs. 134342 TASP for testis-specificadriamycin sens 1. 43 1. 36 1. 49 416084 L16991 Hs. 79006 deoxythymidylate kinase (thymidylate kin 1. 43 2. 15 1. 57 407826 AA128423 Hs. 40300 calpain 3, (p94) 1. 43 1. 61 1. 69 439070 Ai733278 Hs. 7621 ESTs 1. 43 2. 10 1. 40 444090 S69115 Hs. 10306 natural killer cell group 7 sequence 1. 43 2. 09 1. 24 420162 BE378432 Hs. 95577 cyCin-dependentkinase4 1. 43 2. 13 1. 54 442591 AW292797 hypothetical protein MGC10772 1. 43 2. 11 1. 61 451668 Z43948 Hs. 326444 cartilage acidic protein 1 1. 43 1. 49 1. 16 423639 AB037826 Hs. 130411 KIAA1405 protein 1. 42 2. 08 1. 51 426234 BE314534 Hs. 168159 apoptosis regulator 1. 42 1. 57 1. 31 424263 M77640 Hs. 1757 L1 cell adhesion molecule (hydrocephalus 1. 42 1. 88 1. 63 430294 Api538226 Hs. 32976 guanine nucleoüde binding protein 4 1. 42 1. 46 3. 18 447126 AW150632 Hs. 170307 Ral guanine nucleotide exchange factor R 1. 42 1. 36 1. 38 432241 Al937060 Hs. 6298 KIAA1151 protein 1. 42 1. 58 1. 98 412471 M63193 Hs. 73946 endothelial cell growth factor 1 (platel 1. 41 2. 09 1. 29 434262 AF121858 Hs. 12169 sorting nexin 8 1. 41 3. 07 1. 41 432238 AL133057 Hs. 274135 HomosapiensmRNA ; cDNA DKFZp434K1815 (f 1. 41 1. 82 1. 43 402474 NM_004079 : Homo sapiens cathepsin S (CTSS 1. 41 1. 32 1. 24 419897 X90826 Hs. 93649 upstream transcription factor 2, c-fos i 1. 41 1. 69 1. 80 417621 AV654694 Hs. 82316 interferon-induced. hepatitis C-associat 1. 41 1. 22 1. 74 424441 X14850 Hs. 147097 HZA histone family, member X 1. 41 1. 74 2. 15 406663 U24683 immunoglobulin heavy constant mu 1. 41 1. 51 2. 03 409614 BE297412 Hs. 55189 hypothetical protein 1. 41 1. 54 2. 20 443885 H91806 Hs. 15284 ESTs 1. 41 1. 19 1. 41 412276 BE262621 Hs. 73798 macrophage migration inhibitory factor 1. 40 1. 88 1. 24 425179 AJ224442 Hs. 155020 putative methyttransferase 1. 40 1. 84 1. 47 418699 BE539639 Hs. 173030 ESTs, Weakly similar to ALU8_HUMAN ALU S 1. 40 1. 27 2. 79 432403 AA550815 Hs. 124840 ESTs 1. 40 1. 83 1. 44 417389 BE260964 Hs. 82045 midkine (neurite growth-promofing factor 1. 40 1. 65 2. 51 422596 AF063611 Hs. 118633 2'-5'-oligoadenylate synthetase-like 1. 40 2. 57 1. 44 435292 N20514 Hs. 172965 ESTs 1. 40 1. 91 1. 43 419424 BE041820 Hs. 38516 Homo sapiens, clone MGC : 15887, mRNA, com 1. 39 1. 57 1. 37 425068 AL048716 Hs. 154387 KIAA0103 gene product 1. 39 1. 27 3. 18 426020 AL110195 Hs. 166017 microphthalmia-associatedtranscription 1. 39 2. 26 1. 40 427740 BE242604 Hs. 180616 CD36 antigen (collagen type I receptor, 1. 39 1. 76 0. 99 403022 C21000178' gi|7341207lgblMF61215. 1jAF22 1. 39 1. 74 1. 36 416111 AA033813 Hs. 79018 chromatin assembly factor 1, subunit A (1. 39 1. 72 1. 39 410103 AW903666 gb : CM4-NN1032-280300-122-bO2 NN1032 Homo 1. 39 1. 46 1. 34 439180 A ! 393742 Hs. 199067 v-erb-b2 avian erythroblastic leukemia v 1. 39 1. 35 1. 79 414057 Api815559 Hs. 75730 signalrecognifonparticlereceptor (d. 39. 49. 17

416511 NM 006762 Hs. 79356 Lysosoma-asociated mulbspanning membr 1. 39 1. 52 1. 44 423984 AF163825 Hs. 136713 pre-B lymphocyte gene 3 1. 39 3. 02 1. 52 448484 BE613340 Hs. 334725 Homo sapiens, Similar to RIKEN cDNA 9430 1. 38 1. 81 1. 39 436856 A1469355 Hs. 127310 ESTs 1. 38 1. 35 0. 99 437179 AA393508 serologically defined colon cancer antig 1. 38 1. 26 4. 14 437912 8E278594 Hs. 5912 F-box only protein 7 1. 38 Z03 1. 40 448664 A1879317 Hs. 334691 splicing factor 3a. subunit1. 120kD 1. 38 1. 52 1. 38 439981 A1348408 Hs. 124675 ESTs, Weakly similar to T 14742 hypotheti 1. 38 1. 48 1. 38 432812 A1935412 Hs. 50162 ESTs 1. 38 1. 43 2. 18 406826 AW516005 Hs. 84298 CD74 antigen (invariant potypeptide of m 1. 38 1. 87 1. 28 446962 A1351421 Hs. 279709 musde specific ring finger protein 1 1. 38 1. 46 2. 23 408787 NM_014784 Hs. 47822 Rho guanine exchangefactor (GEF) 11 1. 38 1. 98 1. 50 428044 AA093322 Hs. 301404 RNA binding motif protein 3 1. 38 1. 29 2. 04 412926 At879076 Hs. 75061 macrophage myristoylated alaninerich C 1. 38 1. 52 2. 62 418255 AW135405 Hs. 37251 ESTs 1. 38 1. 44 1. 75 419745 AF042001 Hs. 93005 slug (chicken homotog), zinc finger prot 1. 37 1. 51 1. 37 448977 X91809 Hs. 22698 regulator of G-protein signalling 19 1. 37 1. 98 1. 45 422609 Z46023 Hs. 118721 siatidase 1 (lysosomal sialidase) 1. 37 1. 75 1. 31 435458 F11872 Hs. 4892 Homo sapiens clone 24841 mRNA sequence 1. 37 1. 38 2. 80 425081 X74794 Hs. 154443 minichromosome maintenance deficient (S. 1. 37 1. 61 1. 62 429849 U33053 Hs. 2499 protein kinase C-like 1 1. 37 1. 71 1. 45 407103 AA424881 Hs. 256301 hypothetical protein MGC13170 1. 37 1. 62 1. 82 452923 BE276018 Hs. 288940 five-span transmembrane protein M83 1. 37 1. 86 1. 37 453941 U39817 Hs. 36820 Bloom syndrome 1. 37 1. 59 1. 37 446755 AW451473 Hs. 16134 senne/threoninekinae10 1. 37 1. 82 1. 48 439755 AW748482 Hs. 77873 87 homolog 3 1. 36 2. 10 1. 35 447630 AI660149 Hs. 44865 lymphoid enhancer-binding factor 1 1. 36 1. 79 1. 67 413821 AA844126 Hs. 55964 ESTs, Weakly similar to C4HU complement 1. 36 1. 91 1. 39 445823 Api478563 Hs. 145519 FKSG87 protein 1. 36 1. 29 0. 33 456760 AW961251 Hs. 127828 guanine nucleotide binding protein (G pr 1. 36 1. 33 2. 01 402542 Target Exon 1. 36 1. 66 1. 46 451050 AW937420 ESTs 1. 36 2. 00 1. 36 444501 AW247624 Hs. 11342 ninjurin 1 1. 36 1. 59 1. 14 413291 NM006278 Hs. 75268 sialyltransferase 4C (beta-galactosidase 1. 36 2. 55 1. 42 438129 AA778647 gb : af87dO3. s1 Scares testis. NHT Homo sap 1. 36 1. 46 1. 32 428398 A1249368 Hs. 98558 ESTs 1. 36 1. 25 4. 95 439704 AW020018 Hs. 293267 ESTs 1. 36 1. 84 1. 48 428782 X12830 Hs. 193400 interieukin 6 receptor 1. 36 1. 27 0. 58 437316 AI683454 Hs. 46801 GCN5tgeneralconorolofamino-æidsynt 1. 35 2. 10 1. 29 439246 A) 498072 membrane-associated tyrosine-and threon 1. 35 1. 81 1. 63 403409 NM005929 : Homo sapiens an6gen p97 (mela 1. 35 1. 64 1. 35 446342 BE298665 Hs. 14846 Homo sapiens mRNA ; cDNA DKFZp564D016 (fr 1. 35 1. 37 2. 33 437740 AA810265 Hs. 122915 ESTs 1. 35 1. 91 1. 35 423973 AF038461 Hs. 136574 arachidonate 12-lipoxygenase, 12Rtype 1. 35 1. 53 1. 10 421506 BE302796 Hs. 105097 thymidine kinae 1, soluble 1. 35 1. 89 1. 57 457760 AA668123 Hs. 134170 ESTs 1. 35 2. 03 1. 43 439769 AA448828 Hs. 30596 Homo sapiens mRNA full length insert cDN 1. 35 2. 06 1. 41 406824 AW515961 Hs. 84298 CD74 antigen (invariant polypeptide of m 1. 35 1. 77 1. 27 429852 A8010445 Hs. 225948 small inducible cytokine subfamily A (Cy 1. 35 1. 52 0. 51 421777 BE562088 Hs. 108196 HSPC037 protein 1. 34 1. 65 1. 61 400328 X87344 transporter 2, ATP-binding cassette, sub 1. 34 1. 77 1. 02 421445 AA913059 Hs. 104433 Homo sapiens, clone IMAGE : 4054868, mRNA 1. 34 1. 77 1. 15 428977 AK001404 Hs. 194698 cyclin B2 1. 34 1. 53 1. 82 418283 S79895 Hs. 83942 cathepsin K (pycnodysostosis) 1. 34 1. 33 3. 45 425848 BE242709 Hs. 159637 valyl-tRNA synthetase 2 1. 34 2. 11 1. 32 431211 M86849 Hs. 323733 gap junction protein, beta 2, 26kD (conn 1. 34 1. 27 1. 97 422758 AF152329 Hs. 284180 protocadherin gamma subfamily C, 3 1. 34 1. 61 1. 75 421579 NM002975 Hs. 105927 stem cell growth factor, lymphocyte secr 1. 34 1. 75 1. 81 416374 NM 001154 Hs. 300711 annexinA5 1. 34 1. 68 1. 55 451092 Ail207256 Hs. 13766 HomosapiensmRNAforFW00074protein, 1. 34 1. 87 0. 81 424778 AA251048 Hs. 153042 lymphocyte antigen 9 1. 34 1. 94 1. 42 421703 A1936513 Hs. 1416 Fc fragment of IgE, low aYinity 11, rec 1. 33 2. 19 1. 48 416700 AW498958 Hs. 343475 cathepsin D (lysosomal aspartyl protease 1. 33 1. 96 1. 18 425923 NM005026 Hs. 162808 phosphoinositide-3-kinase, catalytic, de 1. 33 1. 70 1. 60 418803 U50079 Hs. 88556 histone deacetylase 1 1. 33 1. 28 2. 65 427730 AW250549 Hs. 180577 granulin 2. 09 1. 35 441174 BE312775 Hs. 294005 Homo sapiens, clone IMAGE : 3050476, mRNA, 1. 33 2. 05 1. 33 412738 N34731 Hs. 74562 siah binding protein 1 ; FBP interacting 1. 33 1. 85 1. 35 424528 AW073971 Hs. 238954 ESTs, Weakly similar to KIAAL 204 protein 1. 33 1. 31 2. 06 422599 BE387202 Hs. 118638 non-melataUccells1, pnztein (NM23A) 1. 33 1. 77 1. 43 422997 BE018212 Hs. 122908 DNA replication factor 1. 33 1. 91 1. 39 415323 BE269352 Hs. 949 neutrophil cytosolic factor 2 (65kD, chr 1. 33 1. 16 0. 60 409119 AA531133 Hs. 4253 hypothetical protein MGC2574 1. 33 1. 52 1. 34 419652 AL157485 Hs. 91973 hypothetical protein 1. 32 2. 07 1. 29 415697 AI365603 Hs. 198271 DKFZP56611024protein 1. 32 2. 00 1. 33 434359 AF129536 Hs. 284226 F-box only protein 6 1. 32 2. 07 1. 39 442932 AA457211 Hs. 8858 bromodomain adjacent to zinc finger doma 1. 32 1. 25 1. 91 444029 AW160993 Hs. 326292 hypotheUcalgeneDKFZp434A1114 1. 32 1. 63 1. 44 456974 M12529 Hs. 169401 apolipoprotein E 1. 32 1. 47 0. 85 447733 AF157482 Hs. 19400 MAD2 (mitotic arrest deficient, yeast, h 1. 32 2. 51 1. 23 448610 NM_006157 Hs. 21602 nel (chicken)-like 1 1. 31 3. 12 1. 31 426490 Nom-001621 Hs. 170087 aryl hydrocarbon receptor 1. 31 1. 21 1. 65 427584 BE410293 Hs. 179718 v-myb avian myeloblastosis viral oncogen 1. 31 1. 68 1. 47

417059 AL037672 Hs. 81071 extracellular matrix protein 1 1. 31 1. 30 2. 14 407777 AA161071 Hs. 71465 squalene epoxidase 1. 31 1. 45 1. 43 408536 AW381532 Hs. 135188 ESTs 1. 31 1. 38 0. 90 410423 AW402432 Hs. 63489 protein tyrosine phosphatase, non-recept 1. 31 1. 81 1. 49 422486 BE514492 Hs. 117487 genenearHDon4p16. 3wiihhomologyto 1. 31 1. 63 1. 31 409154 U72882 Hs. 50842 interferon-induced protein 35 1. 31 1. 69 1. 29 425003 AF119046 Hs. 154149 apurinic/apyrimidinic endonuGease (APEX 1. 31 1. 74 1. 39 441406 Z45957 Hs. 7837 phosphoprotein regulated by mitogenic pa 1. 31 1. 43 0. 94 421975 AW961017 Hs. 6459 hypothetical protein FLJ11856 1. 30 2. 53 1. 34 417361 NM 000275 Hs. 82027 oculocutaneousalbinismll (pink-eyedil 1. 30 1. 38 1. 38 425676 AW410656 Hs. 159161 RhoGDPdissociationinhibdor (GDl) alp 1. 30 2. 11 1. 36 427289 A1097346 phosphoserine aminotransferae 1. 30 2. 27 1. 48 427747 AW411425 Hs. 180655 serine/threoninekinase12 1. 30 1. 68 1. 79 422296 AA360231 Hs. 114416 Homo sapiens, Similar to transducin (bet 1. 30 1. 50 1. 30 436481 AA379597 Hs. 5199 HSPC150 protein similar to ubiquiGn-con 1. 30 1. 42 2. 13 423062 NM003655 Hs. 5637 ESTs 1. 30 1. 58 1. 30 439740 AL365512 Hs. 6657 hypothetical protein bK1048E9. 5 1. 30 1. 77 1. 35 409340 BE174629 Hs. 321130 hypothetical protein MGC2771 1. 30 1. 57 1. 51 416920 AA176455 Hs. 80475 polymerase (RNA) II (DNA directed) polyp 1. 30 1. 67 1. 44 430451 AA836472 Hs. 297939 cathepsin B 1. 30 1. 49 1. 16 457400 AF032906 Hs. 252549 cathepsin Z 1. 30 1. 40 1. 21 403506 C3001912 : gi) 6677647) ref) NP033602. 1jzin 1. 29 1. 88 1. 26 424867 A1024860 Hs. 153591 Not56 (D. melanogaterkiike protein 1. 29 2. 64 1. 31 408815 AW957974 Hs. 25485 hypotheticalprotein FW22341 1. 29 1. 79 1. 36 416322 BE019494 Hs. 79217 pyrroline-5-carboxylate reductase 1 1. 29 1. 59 1. 80 440795 AA262133 Hs. 99741 ESTs, WeaklysimilartoPNL1_HUMANPEANU 1. 29 2. 01 1. 43 421846 AA017707 Hs. 1432 protein kinase C substrate 8OK-H 1. 29 1. 70 1. 34 425966 Nom-001761 Hs. 1973 cyclin F 1. 29 1. 63 1. 50 446766 AF083208 Hs. 16178 apoptosis antagonizing transcription fac 1. 29 1. 71 1. 40 406827 AA971409 gb : op92c04. s1 NCl_CGAP_Lu5 Homo sapiens 1. 29 2. 04 1. 35 418613 AA744529 Hs. 86575 mitogen-activated protein kinase kinase 1. 29 1. 41 1. 94 443086 AW977125 sine oculis homeobox (Drosophila) homolo 1. 29 1. 24 1. 29 439146 AW138909 Hs. 156110 immunoglobulin kappa constant 1. 29 1. 99 1. 36 434398 AA121098 Hs. 3838 serum-inducible kinase (SNK) 1. 29 1. 18 1. 32 418322 AA284166 Hs. 84113 cyclin-dependentkinaseinhibitor3 (CDK 1. 29 1. 31 2. 19 400261 Eos Control 1. 29 1. 59 1. 36 413781 J05272 Hs. 850 IMP (inosine monophosphate) dehydrogenas 1. 29 1. 67 1. 53 412315 AW936678 gb : PM2-DT0023-080300-004-a04 DT0023 Homo 1. 28 1. 26 1. 07 420372 AW960049 Hs. 293660 Homo sapiens, clone IMAGE : 3535476, mRNA, 1. 28 1. 85 1. 40 425449 X52056 Hs. 157441 spleen focus forming virus (SFFV) provir 1. 28 1. 45 1. 14 454478 AW805749 superoxide dismutase 2, mitochondrial 1. 28 2. 29 1. 07 410275 U85658 Hs. 61796 transcription factor AP-2 gamma (activat 1. 28 1. 20 0. 93 406016 Target Exon 1. 28 1. 47 1. 31 449609 BE246434 Hs. 289026 guaninenudeotide binding protein (G or 1. 28 1. 26 3. 02 426059 BE292842 Hs. 166120 interferon regulatory factor 7 1. 28 1. 76 1. 23 412773 H15785 Hs. 74573 similar to vaccinia virus Hindlll K4L OR 1. 28 1. 60 1. 30 452700 A1859390 Hs. 288940 five-span transmembrane protein M83 1. 28 1. 51 1. 22 408543 N78098 Hs. 44289 ESTs 1. 28 2. 02 1. 08 408822 AW500715 Hs. 57079 Homo sapiens cDNA FLJ 13267 fis, clone OV 1. 27 1. 28 3. 51 425069 AA687465 Hs. 298184 potassium voltage-gated channel, shaker-1. 27 1. 66 1. 39 444681 AJ243937 Hs. 288316 chromosome 6 open reading frame 9 1. 27 1. 47 1. 55 430794 NM_000166 Hs. 333303 gap junction protein, beta 2, 26kD (conn 1. 27 1. 81 0. 89 430637 BE160081 Hs. 256290 S100 calcium-binding protein A11 (calgiz 1. 27 1. 35 1. 68 440502 Al824113 Hs. 78281 regulator of G-protein signalling 12 1. 27 1. 67 1. 31 441598 A1733219 Hs. 58262 ESTs 1. 27 1. 30 1. 30 431921 N46466 Hs. 58879 ESTs 1. 27 2. 00 1. 16 459345 AW503672 gb : UI-HF-BNO-ad-h-11-0-Ul. r1 NIH MGC_50 1. 26 1. 44 1. 33 452436 BE077546 Hs. 31447 ESTs, Moderately similar to A46010 X-lin 1. 26 1. 20 1. 45 426334 BE305081 Hs. 169358 hypothetical protein 1. 26 1. 22 1. 89 414044 BE614194 Hs. 75721 profilin 1 1. 26 1. 48 1. 51 405268 ENSP00000223174' : KIAA0783 PROTEIN. 1. 26 1. 19 2. 25 416602 NM_006159 Hs. 79389 ProteinkinaseC-bindingproteinNELL2 1. 26 1. 19 4. 03 439529 BE293492 Hs. 293984 hypothetical protein MGC13102 1. 26 1. 83 1. 19 421254 AK001724 Hs. 102950 coat protein gamma-cop 1. 26 1. 61 1. 23 417785 X59812 Hs. 82568 cytochromeP450, subfamilyXXVIIA (stero 1. 26 1. 84 0. 68 419395 BE268326 Hs. 90280 5-aminoimidazole-4-carboxamide ribonucle 1. 26 1. 66 1. 34 418968 NM000078 Hs. 89538 cholesteryl ester transfer protein, plas 1. 26 1. 42 1. 19 441553 AA281219 Hs. 121296 ESTs 1. 26 1. 29 1. 28 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponUn, 1. 25 1. 22 0. 65 424624 AB032947 Hs. 151301 Ca2+dependentætivatorpntteinforsecr 1. 25 1. 17 2. 95 450087 BE293180 Hs. 24379 MUM2 protein 1. 25 1. 78 1. 28 429604 AK001851 Hs. 210778 hypothetical protein FUI0989 1. 25 1. 18 1. 25 429380 AF023268 Hs. 200600 secretory carrier membrane protein 3 1. 25 2. 22 1. 25 440251 AW796016 Hs. 332012 Homo sapiens, clone IMAGE : 3687782, mRNA, 1. 25 1. 90 1. 39 416759 AK000978 Hs. 79741 hypothetical protein Fa10116 1. 24 1. 32 1. 53 435466 BE619165 Hs. 29203 G protein beta subunit-like 1. 24 1. 96 1. 32 450621 AW297288 Hs. 55918 hypothetical protein FU11354 1. 24 1. 61 1. 27 400214 NM007002 : Homo sapiens cell membrane gly 1. 24 1. 88 1. 32 435013 H91923 Hs. 110024 NM 020142 : HomosapiensNADH : ubiquinoneo 1. 24 1. 76 1. 25 414733 BE514535 Hs. 77171 minichromosome maintenance deficient (S. 1. 24 1. 82 1. 42 406851 AA609784 major histocompatibility complex, dass 1. 24 1. 68 1. 19 448498 AA418276 ESTs 1. 24 1. 73 1. 29 440087 W28969 Hs. 7718 hypothetical protein FU22678 1. 24 1. 70 1. 38

411365 M76477 Hs. 289082 GM2 ganglioside activator protein 1. 24 1. 61 1. 16 426502 Y07759 Hs. 170157 myosinVA (heavypolypepude1zmyoxin) 1. 24 2. 65 1. 24 452056 AW955065 Hs. 101150 Homo sapiens, clone IMAGE : 4054156, mRNA, 1. 24 1. 49 1. 50 427390 Api432163 Hs. 268231 HomosapienscDNA : FW23111fis, cloneL 1. 24 1. 17 2. 10 429954 Ai918130 Hs. 21374 ESTs 1. 23 1. 19 4. 77 421178 BE267994 Hs. 102419 zinc finger protein 1. 23 1. 62 1. 28 442609 AL020996 Hs. 8518 selenoprotein N 1. 23 2. 30 1. 24 416188 BE157260 Hs. 79070 v-myc avian myelocytomatosis viral oncog 1. 23 1. 18 0. 90 410127 AA354313 Hs. 58685 CD5 antigen (p56-62) 1. 23 1. 68 1. 23 452244 N33530 Hs. 176674 ESTs 1. 23 2. 93 1. 23 406718 AA505525 Hs. 169476 glyceraldehyde-3-phosphate dehydrogenase 1. 23 1. 56 1. 29 436939 AA853680 Hs. 5345 arginylaminopeptidase (aminopeptidase B 1. 23 1. 68 1. 23 414457 AW514320 Hs. 76159 ATPase, H transporting, lysosomal (vacuo 1. 23 1. 58 1. 20 416929 N20535 melastatin 1 1. 23 1. 92 1. 20 401106 TargetExon 1. 23 1. 82 1. 29 408981 AW500797 Hs. 49427 Gem-interacting protein 1. 23 1. 40 1. 59 413317 U53225 Hs. 75283 sorting nexin 1 1. 23 1. 43 1. 44 422481 AL050163 Hs. 117339 DNAX-aGvation protein 10 1. 23 1. 71 1. 24 425455 AL137522 Hs. 157777 caseinkinæe1, gamma1 1. 23 1. 95 1. 29 451524 AK001466 Hs. 26516 hypothetical protein FU10604 1. 23 2. 07 1. 27 414399 L47345 Hs. 155202 transcription elongation factor B (SIII) 1. 22 1. 87 1. 19 422034 AC006486 Hs. 333069 Ets2 repressor factor 1. 22 1. 55 1. 21 434224 AA380731 Hs. 84 intedeukin 2 receptor, gamma (severeco 1. 22 1. 55 1. 51 429574 BE268321 Hs. 208912 hypothetical protein MGC861 1. 22 1. 49 1. 46 411742 AW247593 Hs. 71819 eukaryotictranstationinitiationfactor 1. 22 1. 64 1. 40 449027 AJ271216 Hs. 22880 dipeptidytpep6daselll 1. 22 1. 63 1. 30 418004 U37519 Hs. 87539 aldehyde dehydrogenase 3 family, member 1. 22 1. 24 0. 71 451481 AA300228 Hs. 295866 hypothetical protein DKFZp434N1923 1. 22 2. 20 1. 26 422739 H20106 Hs. 119591 adaptor-related protein complex 2, sigma 1. 21 1. 55 1. 21 424326 NM_014479 Hs. 145296 ADAM-like disintegrin protease, decysin 1. 21 1. 13 3. 29 404186 NM_019602 : Homo sapiens butyrophilin-like 1. 21 1. 59 1. 21 447604 AW089933 Hs. 301342 hypothetical protein MGC4342 1. 21 1. 25 2. 00 427979 BE379776 Hs. 181309 proteasome (prosome, macropain) subunit. 1. 21 1. 14 1. 25 414509 AW161311 Hs. 76294 CD63 antigen (melanoma 1 an6gen) 1. 21 1. 39 1. 25 428468 AA171388 Hs. 184482 DKFZP586D0624protein 1. 21 1. 66 1. 22 419700 AF084935 Hs. 92357 galætokinae 1 1. 21 1. 63 0. 74 430948 A1347578 Hs. 124015 hypothetical protein MGC2605 1. 21 1. 48 1. 21 448143 AF039704 Hs. 20478 ceroid-lipofuscinosis, neuronal 2, late 1. 20 1. 75 1. 23 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 1. 20 1. 54 1. 29 442173 N76101 Hs. 8127 K) AA0144 gene product 1. 20 1. 54 1. 31 409632 W74001 Hs. 55279 serine (or cysteine) proteinase inhibito 1. 20 1. 18 1. 11 448230 BE395949 Hs. 94814 hypothetical protein MGC2865 1. 20 1. 83 1. 19 403817 NM015271 : Homosapienstripar6temoUf-1. 20 1. 22 1. 61 411678 Api907114 Hs. 71465 squalene epoxidase 1. 20 1. 15 2. 01 452423 AA991724 Hs. 180535 hypothetical protein MGC10966 1. 20 1. 79 1. 20 424046 AF027866 Hs. 138202 serine (orcysteine) proteinaseinhibito 1. 20 2. 34 1. 20 447233 AW246333 Hs. 17901 Homosapiens, clonelMAGE : 3937015, mRNA, 1. 20 1. 93 1. 20 422565 BE259035 Hs. 118400 singed (Drosophila)-like (sea urchin fas 1. 20 1. 32 1. 52 446159 NM 013379 Hs. 14089 dipeptidyl peptidase 7 1. 19 1. 64 1. 22 434563 AW083994 Hs. 9469 pieckstrinhomoiogydomain-containing. f 1. 19 1. 53 1. 45 421541 NM 003942 Hs. 105584 ribosomal protein S6 kinase, 90kD, polyp 1. 19 1. 75 1. 27 450706 AW167578 Hs. 14691 ESTs, Moderately similar to 138022 hypot 1. 19 1. 71 1. 22 430381 NM006411 Hs. 240534 1-acylglycerol-3-phosphateO-æyltransfe 1. 19 1. 66 1. 21 426329 AL389951 Hs. 271623 nucleoponn 50kD 1. 19 1. 17 1. 55 421612 AF161254 Hs. 106196 8D6 antigen 1. 19 1. 73 1. 30 410182 NM 001983 Hs. 59544 excision repaircross-comptementing rode 1. 19 1. 75 1. 18 434171 BE247688 Hs. 347349 KIAA0948 protein 1. 18 1. 73 1. 09 424837 BE276113 Hs. 333034 N-acetyltransferase, homolog of S. cerev 1. 18 2. 13 1. 22 428293 BE250944 Hs. 183556 solutecamerfamily1 (neutralaminoa 1. 18 1. 45 1. 30 453754 AW972580 Hs. 172753 ESTs 1. 18 1. 71 1. 35 439012 BE383814 Hs. 6455 RuvB (E coli homolog)-like 2 1. 18 1. 60 1. 23 422256 M64673 Hs. 1499 heatshocktranscripSonfætor1 1. 18 1. 51 1. 28 439863 BE547830 Hs. 9408 paired immunoglobulin-like receptor beta 1. 18 1. 89 1. 18 430513 AJ012008 Hs. 241586 G6Cprotein 1. 18 2. 07 0. 81 427283 AL119796 Hs. 174185 ectonucleo6de pyrophosphatase/phosphodi 1, 18 1. 13 3. 25 441648 H05734 Hs. 30559 ESTs 1. 18 1. 56 1. 23 418219 AA731836 Hs. 137319 ESTs 1. 18 1. 77 1. 23 406422 Target Exon 1. 18 1. 43 1. 31 414823 AA156531 Hs. 103902 ESTs. Weakly similar to A44861 keratin, 1. 18 1. 66 1. 23 425720 AA362394 Hs. 293984 hypothetical protein MGC13102 1. 18 1. 58 1. 15 419250 AW770185 U5 snRNP-specific protein, 116 kD 1. 17 1. 74 1. 21 454390 AB020713 Hs. 56966 KIAA0906 protein 1. 17 1. 33 1. 35 428471 X57348 Hs. 184510 stratifin 1. 17 1. 19 1. 24 430200 BE613337 Hs. 234896 geminin 1. 17 1. 13 1. 96 412965 L06419 Hs. 75093 procoltagen-lysine, 2-oxogfutarate 5-dio 1. 17 1. 50 1. 22 430122 NM_013342 Hs. 233765 TCF3 (E2A) fusion partner (in childhood 1. 17 1. 69 1. 32 430512 AF182294 Hs. 241578 U6snRNA-associatedSm-likeproteinLSm8 1. 17 1. 12 2. 44 417080 BE392846 Hs. 1063 smallnuclearnbonucleoproleinpotypept 1. 17 1. 93 1. 18 423102 AW067812 Hs. 303025 chromosome 11 open reading frame 24 1. 17 1. 89 1. 17 408393 AW015318 Hs. 23165 ESTs 1. 16 1. 10 1. 91 424292 AA338432 gb : EST43554 Fetal brain I Homo sapiens c 1. 16 1. 61 1. 21 446759 R61463 Hs. 16165 expressed in activated T/LAK lymphocytes 1. 16 1. 45 1. 23 427324 AA159587 Hs. 285932 hypothetical protein FLJ23322 1. 16 1. 50 1. 23

446055 A1815981 Hs. 12909 mucolipin 1 1. 16 1. 49 1. 10 414432 BE378174 Hs. 26506 Homo sapiens clone CDABPOO05 MRNA sequen 1. 16 1. 67 1. 20 417900 BE250127 Hs. 82906 CDC20 (cell division cycle 20, S. cerevi 1. 16 1. 66 1. 32 411305 BE241596 Hs. 69547 myelin basic protein 1. 16 1. 15 4. 29 438930 AW843633 Hs. 343261 hypothetical protein ALI 10115 1. 16 1. 37 1. 34 407239 AA076350 Hs. 67846 leukocyte immunoglobulin-like receptor, 1. 15 1. 82 1. 17 427458 BE208364 Hs. 29283 ESTs, Weak'ysimiiartoLKHUproteoglyca 1. 15 1. 46 1. 32 402160 Target Exon 1. 14 1. 23 1. 12 416881 N32520 Hs. 141358 ESTs 1. 14 2. 42 1. 14 420223 N27807 ribosomal protein L4 1. 14 1. 23 1. 14 450778 U81375 Hs. 25450 solute carrier family 29 (nucleoside tra 1. 14 1. 38 1. 27 429538 BE182592 Hs. 139322 smaitprotine-rich protein 2A 1. 14 1. 16 3. 52 428342 Al739168 HomosapienscDNAFLJ13458fis, donePL 1. 13 1. 13 1. 13 436696 AA725678 Hs. 120487 ESTs 1. 13 1. 22 1. 13 448950 AF288687 Hs. 9275 CGI-152 protein 1. 12 1. 52 1. 19 437696 Z83844 Hs. 5790 hypothetical protein dJ37E16. 5 1. 12 1. 31 1. 08 425009 X58288 Hs. 154151 protein tyrosine phosphatase, receptor t 1. 12 1. 08 1. 20 412099 U64198 Hs. 73165 interleukin 12 receptor, beta 2 1. 12 2. 93 1. 12 407951 W77762 Hs. 79015 antigen identified by monoclonal ant'bod 1. 12 1. 11 3. 43 408116 AA251393 Hs. 289052 Homo sapiens, Similar to RIKEN cDNA 5430 1. 12 1. 50 1. 12 450296 AL041949 Hs. 24756 hepatocyte growth factor-regulated tyros 1. 11 1. 48 1. 12 420697 AA827705 Hs. 26605 ESTs 1. 11 2. 19 1. 11 438915 AA280174 Hs. 285681 Williams-Eeunensyndnomechromosomeregi 1. 11 2. 73 1. 11 418399 AF131781 Hs. 84753 hypothetical protein FU12442 1. 10 1. 43 1. 14 450358 AB010098 Hs. 24907 coronin, actin-bindingprotein. 28 1. 10 1. 35 1. 19 444783 AK001468 Hs. 62180 aniilin (Drosophila Scraps homolog), act 1. 10 1. 43 1. 10 408801 A1866590 Hs. 63405 Homo sapiens, clone IMAGE : 3609337, mRNA, 1. 10 1. 53 1. 14 402622 C1003392-: gil12314272lemblCACO0591. 1l (A 1. 10 1. 59 1. 06 418661 NM 001949 Hs. 1189 E2F transcription factor 3 1. 09 1. 82 1. 09 442680 BE270707 Hs. 8583 similar to APOBEC1 1. 09 1. 49 1. 24 439702 AW085525 Hs. 55964 ESTs 1. 09 1. 68 1. 09 423858 AL137326 Hs. 133483 Homo sapiens mRNA ; cDNA DKFZp434B0650 (f 1. 09 1. 10 1. 73 443759 BE390832 Hs. 134729 FXYDdomain-containingiontransportreg 1. 09 1. 23 1. 25 414396 BE548266 Hs. 76057 gaæioseXepimerae, UDP-1. 09 1. 07 1. 23 401558 ENSP00000220478* : SECRETOGRANIN lil. 1. 08 1. 54 1. 08 428411 AW291464 Hs. 10338 ESTs 1. 08 1. 07 6. 19 422051 AW327546 Hs. 111024 soluiecanierfamily25 (mitochondrial 1. 08 1. 25 0. 93 414694 NM 015362 Hs. 76907 HSPC002 protein 1. 08 1. 18 1. 12 453883 Ai638516 Hs. 347524 cofætorrequiredforSp1transcrip60na 1. 07 1. 15 1. 31 420856 BE513294 Hs. 205736 HLAclasilregionexpressedgeneKE2 1. 06 1. 47 1. 08 412265 AA101325 Hs. 86154 hypothetical protein FLJ12457 1. 06 1. 17 1. 22 429259 AA420450 Hs. 292911 Plakophilin 1. 06 1. 08 0. 73 417381 AF164142 Hs. 82042 solute carrier family 23 (nucleobase tra 1. 05 1. 04 0. 84 415825 Y18024 Hs. 78877 inositol 1, 4, 5-Uisphosphate 3-kinase B 1. 05 1. 09 1. 37 444438 N32755 Hs. 322489 ESTs 1. 04 1. 13 1. 05 407394 AF005081 gb. Homo sapiens skin-specific protein (x 1. 04 1. 22 0. 78 404960 eyes absent (Drosophila) homolog 3 1. 04 1. 06 1. 04 408972 AL050100 Hs. 49378 DKFZP586D0919 protein 1. 04 1. 09 1. 13 414477 U41635 Hs. 76228 amplifiedinosteosarcoma 1. 03 1. 11 1. 03 409327 L41162 Hs. 53563 collagen, type IX, alpha 3 1. 03 1. 02 2. 33 435056 AW023337 Hs. 5422 glycoprotein M6B 1. 03 1. 02 3. 56 415314 N88802 Hs. 5422 glycoprotein M6B 1. 02 1. 02 4. 02 408591 AF015224 Hs. 46452 mammaglobin 1 1. 00 1. 41 0. 05 401203 Target Exon 1. 00 1. 02 0. 98 400304 AF005082 Hs. 113261 Homosapiensskin-specificprolein (xp33 1. 00 1. 49 0. 56 407395 AF005082 gb : Homo sapiens skin-specific protein (x 1. 00 1. 69 0. 91 411388 X72925 Hs. 69752 desmocollin 1 1. 00 3. 12 1. 00 428618 AA885360 Target CAT 1. 00 1. 77 1. 00 402860 ENSP00000239210 : DJ50024. 4 (novel protein 1. 00 1. 53 1. 00 437211 AA382207 Hs. 5509 ecotropic viral integration site 2B 1. 00 1. 39 1. 00 409269 AA576953 Hs. 22972 steroid 5 alpha-reductase 2-like ; H5AR g 1. 00 1. 46 1. 00 409190 AU076536 Hs. 50984 sarcoma amplified sequence 1. 00 0. 80 1. 00 416143 AI955650 glutaminyl-peptide cyclotransferase (glu 1. 00 1. 96 1. 00 401588 C15000180' : gil544344lsplQO5859lFOR4 MOUS 1. 00 2. 04 1. 00 419519 Api198719 Hs. 176376 ESTs 1. 00 1. 91 1. 00 448816 AB033052 Hs. 22151 KIAA1226 protein 1. 00 1. 82 1. 00 440270 NM 015986 Hs. 7120 cytokine receptor-like molecule 9 1. 00 1. 15 1. 00 418618 U66097 Hs. 86724 GTP cyclohydrolase 1 (dopa-responsive dy 1. 00 1. 66 0. 74 422836 AL037365 Hs. 194093 AKAP-binding sperm protein ropporin 1. 00 2. 21 1. 00 452461 N78223 Hs. 108106 transcription factor 1. 00 1. 61 1. 00 428479 Y00272 Hs. 334562 cell division cycle 2, G1 to S and G2 to 1. 00 1. 42 1. 00 422420 U03398 Hs. 1524 tumor necrosis factor (ligand) superfami 1. 00 1. 81 1. 00 429477 A1275514 Hs. 6658 ESTs 1. 00 1. 67 1. 00 454027 R40192 Hs. 21527 Human DNA sequence from clone GS1-1 15M3 1. 00 1. 05 1. 00 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h 1. 00 1. 79 1. 00 451993 AA765776 Hs. 122983 ESTs 1. 00 2. 15 1. 00 416947 N23282 Hs. 184341 ESTs, Weakly similar to B34087 hypotheu 1. 00 1. 67 1. 00 441606 R37263 Hs. 21065 ESTs, ModeratelysimilartoPC4259fem 1. 00 1. 87 1. 00 442590 Al002686 Hs. 130313 ESTs 1. 00 2. 59 1. 00 404831 C1002937* : gil74992081 pi JIT 20993 hypothe 1. 00 1. 44 1. 00 428454 U55936 Hs. 184376 synaptosomal-associated protein, 23kD 1. 00 1. 47 1. 00 419717 H07970 Hs. 92458 G protein-coupled receptor 19 1. 00 1. 78 1. 00. 408611 NM_004367 Hs. 46468 chemokine (C-C motif) receptor 6 1. 00 1. 64 1. 00

421666 AL035250 Hs. 1408 endothelin 3 1. 00 0. 63 1. 00 446155 Al553695 Hs. 159422 HomosapienscDNAFW13997fis, doneY7 1. 00 1. 60 1. 00 423899 NM_001427 Hs. 134989 engrailed homolog 2 1. 00 2. 91 1. 00 423130 AW897586 Hs. 21213 ESTs 1. 00 1. 65 1. 00 433843 AW021423 Hs. 112819 ESTs 1. 00 2. 08 1. 00 458574 AW384436 Hs. 135265 Homo sapiens clone FLB8436 PR02277 mRNA, 1. 00 1. 00 1. 00 430205 AB025904 Hs. 235168 carbonic anhydrase XIV 1. 00 1. 41 1. 00 427335 AA448542 Hs. 251677 G antigen 7B 1. 00 1. 15 1. 00 439951 A1347067 Hs. 124636 ESTs 1. 00 1. 80 1. 00 420248 A1377191 Hs. 44714 ESTs 1. 00 2. 15 1. 00 446259 AA425204 Hs. 334721 hypothetical protein FU13391 1. 00 2. 35 1. 00 447164 AF026941 Hs. 17518 vipirin ; similar to inflammatory respon 1. 00 1. 53 1. 00 447289 AW247017 Hs. 36978 melanoma antigen. fami) y A. 3 1. 00 1. 73 1. 00 408758 NM 003686 Hs. 47504 exonuclease 1 1. 00 1. 59 1. 00 453745 AA952989 Hs. 63908 hypothetical protein MGC14726 1. 00 1. 73 1. 00 436609 A1022514 Hs. 131380 ESTs 1. 00 1. 96 1. 00 419308 N40321 gb : yx80gO7. r1 Soares melanocyte 2NbHM Ho 1. 00 2. 28 1. 00 421650 AA781795 Hs. 122587 ESTs 1. 00 1. 74 1. 00 459578 AW612538 Hs. 304491 EST 1. 00 2. 16 1. 00 446152 Al292036 ESTs 1. 00 1. 66 1. 00 449579 AW207260 Hs. 134014 ESTs, Weakly similar to T46425 hypotheti 1. 00 2. 04 1. 00 418673 NM_005582 Hs. 87205 IymphocyteanUgen64 (mouse) homolog (1. 00 1. 75 1. 00 415004 AA158925 Hs. 240849 ESTs, Weakly similar to GBP1 HUMAN INTER 1. 00 1. 85 1. 00 426274 D38122 Hs. 2007 tumor necrosis factor (ligand) superfami 1. 00 1. 92 1. 00 453922 AF053306 Hs. 36708 budding uninhibited by benzimidazoles 1 1. 00 1. 72 1. 00 417791 AW965339 Hs. 44269 ESTs 1. 00 1. 52 1. 00 424905 Nom002497 Hs. 153704 NIMA (never in mitosis gene a)-related k 1. 00 2. 02 1. 00 416445 AL043004 Hs. 79337 KIAA0135 protein 1. 00 1. 28 1. 00 408375 A1224520 Hs. 40930 ESTs 1. 00 1. 92 1. 00 406964 M21305 FGENES predicted novel secreted protein 1. 00 0. 46 1. 00 408522 Ai541214 Hs. 46320 Small proline-rich protein SPRK human, 1. 00 1. 00 2. 48 412828 AL133396 Hs. 74621 prion protein (p27-30) (Geutzfeld-Jakob 0. 98 0. 98 3. 24 422270 AF114494 Hs. 114062 protein tyrosinephosphatase-iike (proii 0. 95 0. 96 3. 06 446488 AB037782 Hs. 15119 KIAA1361 protein 0. 94 0. 96 1. 61 433435 BE545277 Hs. 340959 Ts translation elongation factor, mitoch 0. 94 0. 94 0. 76 409402 AF208234 Hs. 695 cystatin B (stefin B) 0. 93 0. 91 1. 55 423942 AF209704 Hs. 169407 glycolipidtransferprotein 0. 92 0. 93 2. 09 414219 W20010 Hs. 75823 ALL1-fused gene from chromosome 1q 0. 91 0. 91 4. 08 429211 AF052693 Hs. 198249 gap junction protein, beta 5 (connexin 3 0. 90 0. 81 0. 73 417632 R20855 Hs. 5422 glycoprotein M6B 0. 90 0. 92 3. 89 449092 U91641 alpha2. 8-sialyltransferase 0. 89 0. 79 0. 84 426716 NM006379 Hs. 171921 sema domain, immunoglobulin domain (1g), 0. 89 0. 92 3. 70 445033 AV652402 Hs. 72901 cyclin-dependent kinae inhibitor 2B (p1 0. 88 0. 90 2. 02 408349 BE546947 Hs. 44276 homeo box C10 0. 88 0. 87 0. 73 429345 R11141 Hs. 199695 hypothetical protein 0. 85 0. 84 0. 69 451621 Al879148 Hs. 26770 fatty acid binding protein 7, brain 0. 84 0. 85 1. 32 417022 NM_014737 Hs. 80905 Ras association (RaIGDS/AF-6) domain fam 0. 84 0. 88 3. 37 405885 Target Exon 0. 81 0. 71 1. 00 407788 BE514982 Hs. 38991 S100 calcium-binding protein A2 0. 78 0. 78 0. 90 417515 L24203 Hs. 82237 ataxia-telangiectasia group D-associated 0. 77 0. 73 0. 71 421100 AW351839 Hs. 124660 HomosapienscDNA : FLJ21763 fis, clone C 0. 75 0. 78 4. 69 440274 R24595 Hs. 7122 scrapie responsive protein 1 0. 74 0. 78 5. 42 425071 NM013989 Hs. 154424 deiodinase, iodothyronine, type 11 0. 70 0. 75 4. 29 412719 AW016610 Hs. 816 ESTs 0. 70 0. 77 3. 99 432467 T03667 Hs. 239388 Human DNA sequence from clone RP1-304B14 0. 69 0. 73 3. 79 437191 NM 006846 Hs. 331555 serineproteaseinhibitor, Kazaltype, 5 0. 65 0. 64 1. 11 452487 AW207659 Hs. 6630 Homo sapiens CDNA FU 13329 fis, clone OV 0. 61 0. 65 3. 20 448133 AA723157 Hs. 73769 plate receptor 1 (adult) 0. 61 0. 22 0. 49 439659 AW970780 Hs. 59483 HomosapienscDNAFW14471fis, cloneMA 0. 49 0. 30 0. 67 419092 J05581 Hs. 89603 mucin 1, transmembrane 0. 41 0. 11 0. 34 417079 U65590 Hs. 81134 inteneukint receptor antagonist 0. 23 0. 30 0. 35 TABLE 49B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 430540 713_2 BC017171 BC012195 NM_007126 AF100752 AL137377 Z70768 BM474865 BG754806AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 B1759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 Ai770171 BF196861 BE856897 AA463876 At375927 AA648810 AA948193 AA490916 Al459393 Al458188 Al240408 Al191843 Al131029 AW768399 Api365196 AW337984 AW026150 BE466591 BE674599 A1818438 AA772197 A1651927 AW151143 81198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 B1227204 BG761305 BE262642 BE391848 BE382475 BG008258 B1547991 B1459099 BE391391 BE259420 BE298109 AW245422 Al423847 Api914618 H80534 BE301004 AL531791 Ai435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 A1359493 BM018598 Api689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 A1421728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 B1041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 81091658 N72512 W58732 W85690 BG958989 A ! 205206 H19721 W17051 W77958 B126201 0 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018AA740241 A) 027722Ai150356 AA886395 AW977627 BE220225 AA884082 AW518114 AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 A1918399 Al537550 M491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU 185751 AW971465 AA489681 AW971893 AW612086 BE077936 B1860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 431317 997174_1 AW970601 AW613399 AA503435 AA502682 N91138

453912 325623 BM472224 B1966849 81966735 AW973032 B1962894 B 963048 AA548765 AI926504 AA041551 AW043754 A1086702 AW008105 AA974849 AW614893 AA553737 AA916996 AW262982 Al580991 BF726843AV693312 W35325 AA039927 BG460936 AW388482 AW388420 BF374777 W01360 N94710 H87967 420218 191547 1 AW958037 R42557 AI337047 AA948360 AI638005 AA459950 AI624915 AI638047 AI467856 AI521826 AA860305 AI932315 AW003092 AW271756 AW779380 AA609879 AI634791 AI493770 AI565211 Z41145 AI627952 AA303734 BE349457 AW196765 AA256527 BE089727 458997 11847 4 BM453041 AA760783 BE218582 AI340046 AW1661318F515854 AI630296 AA461307 A1090881 AW023059 AA155797 AA115486 AL597396 AW889004 AW937420 AA137082 AA013374 BG619478 BG401839 430015 713_2 BC017171 BC012195 NM_007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 B1759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 A1770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 Api365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 B1227204 BG761305 BE262642 BE391848 BE382475 BG008258 8154799181459099 BE391391 BE259420 BE298109AW245422 Al423847AI914618 H80534 BE301004AL531791 A'435581 BF793112 AL577303M373265 BE746965 BF743630 BE879296 Al359493 BM018598AI689260AW072450 F20201 AW151405AW517572M773468 BG259694 BE391163 BG621529AI421723 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 BiO41981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 B1091658 N72512 W58732 W85690 BG958989 A1205206 Hl 9721 W17051 W77958 Bl 262010 M844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 A1243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 81860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 425231 235504_ 1 AA527161 BG211784 AA527065 AA505489 AW512550 417282 2142_2 AK025474 U11293 AF141304 BM424202 AL539819 AL554793 AL5437W AL549509 81753328 BG756797 BI856494 BE901116 AL556989 AU733347 B1838505 AW949559 BM012604 BG773980 BG661309 B1260149 BF436764 BG983060 BF822225 81059728 8F917866 BF917609 BF914374 D31003 AA234218 AJ420466 BM083921 BE856788 BE669957 BF430992 AW614978 AW205958 BF110763 BF222758 AA195232 AI341353 AI698676 A1093230 AI123522 AI656594 AI208758 AA975916 A1089224 AI264922 AA256604 AA659637 BE218707 AA195203 AW999239 AW139706 N31717 AW205941 R95955 N39147 BM015411 AL576975 BF689524 AL563130 B1858155 AA417889 AL513995 AL568815 AU160693AA836028 H84388 AL517078 AL546480 AL530507 AL561042 AA024435 W47314 AI680513 AA456116 BF836679 AW975173 H24039 AW105059 BE548113 AW370257 BM011139 AW675130 BE276045 BF933396 AL517903 AA886367 BI030596 BG477193 BF973867 406687 0 0 M31126 452194 90339 1 AI694413 AW994700 Api912946 N73548 A1082035 AW271652 W24189 W24182 AI719718 AA024658 AW810120 AW015394 T79755 AA988043 A1709339 442643 2736_1 BC001588 BC007424AF016369 NM_004697 Bl756186 BE257019 BG500792 B) 862776 AL121371 BG574833 AA703250AA179511 AW052006 AI280150 AI914000 AI358319 AI081204 A1082594 AA992449 AI470821 AI655744 AW237529 M678853 Al984430 BF433055 BE467594 BE467573 AA035630 AI289987 AI184802 AI681391 AW592416 AI138377 AI139266 AA961714 A1800163 AA418751 AW451928 AA668676 At273444 Api494387 BE046912 A1276555 BF1 96021 AA700055 AA609305 AA772596 A1635758 A1635749 H95459 AW610290 BE464994 AA527136 BF374802 AI800175 AW195227 Al 189676 BF802049 AL513632 AL554911 AL538845 BE297273 AA315321 BM451920 BE269268 BE292835 BE018128 BG755713 BM041095 BG677009 AL039691 BF995709 BE735586 BE296453 BG393609 BG824453 AL567522 A1745257 AW388641 AW301265 Al 141144 AW029280 AU149362 AU152328 AA418960 AL121009 Al890398 AL528748 H13050 T47086 B1000575 BF334914 BF109661 R44450 H13259 T47087 AW388646 BF305834 AL577515 BM041600 BE889299 BF239768 448243 13061 2 BG166513 AA479726 BE622314 AL134913 BE006305 BE006312 BE006298 AA044582 AW994956 AA234175 AA043906 BE006303 BF327669 BE006317 BF326759 BF541959 430441 1438_6 BG108218 BE560548 AW380115 BE269629 AI911518 AW380113 AA902964 AA455001 AI276529 AI685597 AA970496 D61084 AW380068 AW380080 R00283 C15236 AW327776 D80759 432810 101919_1 BG292389 C06094 A1668930 AW1 04534 AA310513 AA830i 27 AW1 34897 AA046953 AW965490 A1810530 8F092924 AA334151 AA334725 D31302 R20723M263003 Bl824635 Al276287 Al684428 Al524234 Al335035 AW014704 AI911443 AA972102 AI367512 AI126670 AW016017 Al286003 AI147163 AA626033 AI539156 AA565542 A1094253 AW512612 BE889628 AA744752 BE646306 AW471324 AA999975 AA863400 H17550 Ai991439 R46187 BE929954 AA333976 D63102 BF744491 446019 658727_1 Al362520 D25917 Al670784 Al742347 AW269789 Al270700 AW610541 AW793036 AW793035 AW610540 AW362220AW362166 AW362214 AW362225 AW362228 AL119827 453331 16559_1 BG571303 M410586 M035018 BG572117 BG620022 AA147247 BG005785 BG014448 R31981 H02668 H12498 R36203 BF992089 R73999 T49904 R75732 Bol057974 T53681 AA147933 N50695 R68588 R25671 R31935 R25110 R36105 AK055628 BE157467 AW663674 M190993 H01642 BF510304 AA626915 AA746952 Al 161014 AA099554 BG572534 AI803329 AI809932 AI808765 AA411449 A1378760 AA976929 AI378620 AA909684 R75632 AI360919 AI350463 AW069127 AA411621 AA742532 H12451 BE208298 H03612 H 12839 N58781 R75957 BF996484 A1240665 BF989591 B1056086 BG001590 BF107035 429978 35194_2 BE738425 BE738323 BM126944 AW629678 AW265195 Al916735 Al394255 Al573090 Al354442 AW612857 AI339558 AI919424 AI377532 AI354441 AI308821 AA772275 AW055215 AI589705 AI336532 AA806547 AV682125 H93575 AW071172 AW769904 AI863985 AW265018 AW196655 D79662 BE042393 N75017 AW014741 C75509 BE748621 H92431 AW079261 AW901780 AA329482 AW960115 B1260621 AI767525 R31663 BI918664 AW963196 C06195 A1678018 452203 2630 1 BC014081 NM 000593 X57522 L21208 L21207 L21206 L21205 L21204 AL561404 AL546423 AL560492 AL556882 AL541576 AL550654 BI823519 Bl770023AL554969 Bl489906Al304693AW295947 BM146642 X57521 BG820143 BE898390 F06770 F12630 BM423610 AL561518 BM009470 BG742981 AA279685 AA847441 AA313737 BF172639 BF897216 BF914190 BF903647 S70277 AI569694 AW073296 A1361433 AA564644 AA487429 BE858232 M838610 Al539114 Al719375 Al829129 BG057675 AI423422 AU158860 8E300655 AW170777 AA586956 AL571889 AL556850 AL576404 AL582800 Bl256544 BF342301 BG875994 AA054458 AA353161 Api940434 BE816522 AL577636 AI479650 AW150377 AU 154395 AW951271 A1032220 AI819778 AI346733 AW771150 AW512525 AI249904 AA279809 AI352549 AW512517 BG056280 AA521222 BE271141 AL581932 AL541575 81819184 AV660190 AL556475 Api620020 AW089888 AW079179 Z21518 AA687601 F04651 Al783961 T57198 Al433367 T78652 AL554968 AA365648 AL582619 BE874601 BF804669 AL574458 BM145502 AI266514 AI538823 AI475626 AA948210 AA884054 AA487637 AA031 &44 AA535221 AW794256 AW361447 BE788505 AI682892 AA830989 AA862356 AA653084 BM009154 AA135727 H05927 H23433 R42244 N79997 AW366665 AW366601 AA678742 AL556474 AA135770 BE774050 BF914200 H88457 AA627746 B1560216 81753586 458098 23945 1 A1082245 BE467534 AI797130 BE467063 BE467767 BE218421 AI694996 BE327781 BE327407 BE833829 AA989054 AA459718 BE833855 BE550224 AA832519 AF086393 AV733386 BE465409 N29245 W07677 AA482971 BE503548 H18151 AA461301 W79223 W74510 A1090689 AL600773 AL600781 N46003 R28075 R34182 BE071550 AW885857 Al276145 Al276696 H97808 N20540 Al468553 424399 21961 NM 058173 AF414087 W72837 BF742809 AW070916 BE092421 Al905687 AA340069 BE074512 Al905623 Al905633 BG202312 W72838 Api139456 BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 Al127172 BE815319 Al905624 R75793 BG202313 AI905837 BE815853 427239 20459_2 AL532360 BE794750 AA582906 A1015067 AW271034 BG271636 AW075177 AW071374 Al345565 Al307208 BE138953 BE049086 Api334881 AW075006 AW075181 AA464019 AW302733 AW075100AW073433 Al802854 Al334909 Al802853 Al345036 Al348921 Al340734 Al307478 Al251289 AW302327 AW072520 A1312145 AW073656 AW072513 AW071289 A1307559 AA876186 T29587 Al307493 Al255068 Al252868 Al252839 AW074809 AI252926 AI252160 AI251662 AI251262 AI610913 A1270787 AI270156 AI252075 AW073469 AW072901 AW072496AW071420Ai305762 Al254764 Al802837 Al251264 AW073049 AW071311 Al340643 BE138965 BE138502AW073456 Al334733 Al054335 BE139260 Al054302 Al054060 Al054057 A1053722 AI289711 BE139228 AW470478 AW271039 AW302085 BE041872 AI254494 AI271496 AI252427 BF718773 BF718645 AW074866 BE857822 400222 9287 Nu002082 L16862 BG828886 BE795217 BE904064 BE294526 BE297283 BE394617 BE935127 BE935106 F12351 BG823182 H16710 410600 497855_1 BF347859 AW499616 AA191322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 Api335824 AW408712 BM149172

417324 292720_1 BG775668 BG680336 AW991605 AA455904 AW265494 AW265432 BF911380 AA456370 BF911379 AA195677 BF914311 BF913866 BG775059 BG951874 Al572169 453613 10943_2 BG121705 BF514513 BE812196AW173164 Al911266Al161253M906295M724987 M972070AW085313 B1062611 BG119864 W02997 H80902 T91294 H09335 H09332 Z40007 F10399 F02595 F03100 H38987 Api801190 H80903 AW130044 F10391 T80640 H24461 R46234 R51914 411825 7891_1 AK000695 AK000489 BC001688 BG235988 AW006329 AI887644 AI207230 AI148213 AI304333 AI634653 AW662636 A1281247 AA946921 AA424487 BE272330 AI830588 AA159183 AA977141 BG231801 AA631793 AA975194 BF817537 AA477798 61906631 AW083424 AA625199 NM 017767 AK000334 BF984048 AW815634 AL573992 AA430612 AA928390 AA464447 AW340827 AA424290 Api927759 BG951502 AW881353 B1765535 400270 32329_1 AF067853 NM 000026 X65867 BC018881 S60710 BG686218 BG707897 BI767531 BE742167 BG747544 BG768400 BG323811 AU119991 BG763638 BG393097 BG761706 BI766890 81457560 BG122629 BF972974 BI 194649 BE909022 BG488681 AW328441 AW248366 BG718034 B1598504 BE264146 AW248440 BE410942 BE256756 Al480227 Al758918 BE251966 Api684330 AW518872 AW264087 AA631137 Al742831 Al990690 Al192994 AA417231 AA455931 AA416541 AI652537 AI803674 AA631209 AI923786 AW205704 AI354260 AI198865 BF593386 AW821194 Api693442 AW797594 BE893700 BF242879 8E251315 AA534659 AA49455181047923 BG949898 BF246869 Bl085069 BM007035 M665981 Al375483 BG221393 Al867530 AA128025 AW612345 R12769 W92325 R40084 AA191625 D51044 AA599257 BE878335 AA121664 Al146666 BI026299 A1872956 AA788642 AA128068 BF819623 Al277591 Al435105 Al354905 AV747031 442591 58995 1 BC021240 BF430978 BG056212 AW874052 Bl856040 Al572156 Al914600 Al002736 BM023413 H91902 AL563177 AL529967 BM023140 BE391587 BG761312 BE277571 Bl195388 BE389566 H91851 BE391930 BE391441 410103 366775_1 BG003993AW589921 AW892489AW903666 437179 12239 1 AK055109 BC019085 AA187684 BG656226 BM023227 Api932311 AW264381 AA398371 BM021483 Al432433 Al375777 Al129580 AW262782 AA134107 BM023515 AA977504 Al859222 Al343454 R69725 AA975268 BM021207 AL080074 AA129218 AW207842 N90581 AA771919 A1092259 A1028416 A1074114 BG656536 BE501677 AW193419 AA917040 W90430 AI342984 AI378957 AL036486 AW020068 81491093 BF476021 R41226 R69631 F04125 C02343 AA115589 R56480 A1400988 R54266 R31422 451050 11847_4 BM453041 AA7607838E218582At340046AW166131 BFS15854A ! 630296AA461307Ai090881 AW023059AA155797AA115486AL597396 AW889004 AW937420 AA137082 AA013374 BG619478 BG401839 438129 497522-1 BE904404 AA778647 BF431869 AW070999 8G170122 BG191943 BG999184 R42302 439246 388 5 AK054564 AF086057 AI869310 BG393141 BE220500 AI479459 AI866575 AI361301 AI674602 BF001506 AW004996 AI446292 AI890883 AI608681 AW131794AI356096AI4330408GO5701BA1696166AW081428AI392809AA98 5226AW190187BE896007 BG171443AW516382AA731186N50847 AA417728 F27148 A1003145 AL520675 AL577680 AL578955 AA316669 BF804796 AA768324 A1285396 BG745142 BG325246 BG475289 AL580501 AA832445 AA832168 BF063242 AW251083 BF345614 BE871009 BG698638 BG978245 BG978247 427289 1820 2 BC007350 BG766159 BG769338 BG761999 BG744385 8770572 AW370610 AW370581 AA978353 AW327973 AW402425 AI889380 AA868504 AW612968 AA630644 A1751211 N26980 Al394506 AA747849 BF154926 BF477185 AA649647 R39135 Api750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW370651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 B1261497 B1018403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 Bol018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340083 Z20199 406827 0 0 AA971409 443086 25669_4 BE896316BG319393M187888AW753122 400261 231101 BC006097 X03066 NM002120 M26040 AW469119 AW469127 Al299772 AW518149 AI144456 AW628070 Al629032 Al358810 Al880433 Al440472 Al357070 Al865365 AW014799 Api767973 AW518041 AA909398 AW768606 412315 1163860 1 AW936678 AW936821 AW936683 AW936822 AW936781 AW936817 AW936811 AW936653 AW936823 AW936685 AW936815 AW936637 AW936812 AW936730 AW936762 AW936682 AW936732 454478 4273_16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 459345 9197061 AW853325AW503672 400214 9255_1 Al659839 BE897640 BE907077 BC003059 BC017245 BC010733 BM423383 AL537826 AL580324 BG749884 BE910412 B1085225 BG830374 BG765711 BE513420 BE513706 AW249005 BE378229 BE250756 BG389441 BF998736 H61321 BF869238 BG979991 H49658 AA353290 D64154 BM468130 AL549088 Bol765497 AL556922 Bol833272 BM009270 Bol546248 BG750170 BG480128 AL561553 Bol559389 BG762029 BG741197 Bl561200 B1259044 AL523216 BG333073 B1838073 BE790691 AV762878 BF972560 B1260209 B1333058 B1090606 BG468883 B1598273 81826098 BE622086 Bl758061 BG751116 BE905428 BG764482AL522174 BG761428 Bol836634 BG749048 BG774512 BE280653 BG480630 BG716728 Bol766635 BG573991 BG389305 BF971754 BG680599 BE795075 BG324709 AA984290 BE304564 BG283813 BE252914 BF872431 BE407696 BE264894 AL552517 BF872428 BF724779 BE279635 BF804329 BE764960 BF811388 D31335 AW951318 BF992435 BF811453 NM007002 AL518634 AL574934 AL523534 AL520445 AL521785 AL547001 AL558522 B1829145 81862487 B1753281 BE258642 AL039594 BG015181 BE925165 BF872433 A1904540 AI904495 AA776741 AA317533 BG476628 R13328 BG489456 BF 102495 BF693420 AL526597 BG104181 BG740214 BE393189 AI986312 H61596 AW051180 Bl668762 AW938619 Bl086232 M053472 BE264345 406851 0_0 AA609784 R97304 448498 200784 BG167206 AA677283 AA677217 AI703389 A1051577 A1912137 H39571 M650047 Al399798 H24807 AA341614 BG945259 Al074162 AW960920 AA628934 AA659498 AA699617 H14450 H21758 H39576 AA095608 A1049973 BG054505 BG319545 AI742408 AA421324 AI580138 AI375883 AI374848 AI367657 AI374762 AI304678 AA007357 BF477168 AI373751 AA779885 AI801494 BE349021 A1220937 AW338397 AA253409 AA418327 AA872682 AI572030 AI521517 AI572944 AI418670 AI266089 W72413 W76492 AI809207 AI915747 H22230 H21951 H08513 H25154 416929 14596_3 BC017849 BC005892 N42983 BF691239 N42991 N29240 N40292 N33322 N33330 N20535 419250 249447_1 BG755078 Bl226909 N41827 AW404060 Bol058921 H11253 AA461274 R05714 H00515 B1086965 A1032786 Bol089613 BM171783 Ai 127382 Al660953 AW296271 AI582209 AA460965 AI376115 A1016900 BG055846 A1023644 AA767046 AA815039 AW403510 AI868663 AA815462 AA235654 AW292253 AW959582 AV725205 AW959578 M300091 W24933 R05715 AW770185 H00465 N93714 H11254 T49555 424292 892193_1 AW966308M339512M338432 420223 191648 1 N27807 AA256634 BE276324 428342 6712_1 AK056315 Al015524 M724079 Bl713619 Al377728 AW293682 Al928140 Al092404 Al085630 M731340 BM469629 AW968804 AA425658 AA769094 BF446026 AW118719 Al332765 AW500888 AW576556 Api859571 AW499664 AW614573 AW629495 AW505314 W74704 A1356361 A1923640 AW070509 Al521500AL042095 M609309 M761319 Al381489 H45700 AA761333 AW265424 AA909524 AA635311 AA649040 A1392620 Z40708 Api985564 AW263513 AA913892 Al693486 AW263502 Api806164 AW291137 81061872 81059498 AA134476 AW084888 AA036967 AW370823 T55263 81002756 AA489664 BF827261 W74741 BF963166 407394 27110_2 AF005081 BG193848 428618 2668_1 BC017998 Bl826643 BG715794 BG722697 Bl460787 BG773459 H52859 Al652853 Al990773 AW665193 AW340601 AA913806 Api337099 BE045942 AW572790 AW515652 H 15004 AA909115 B1465310 B1462024 B1561578 B1463075 BG722527 R86003 BG623286 H15003 81562131 BG435272 416143 40539_2 BG218868 AV705271 N34153 AL538368 BG186620 BG188697 BG181900 Al200440 BG033721 BF968528 BF792647 AW204668 M922311 F02735 AW342041 BG217293 BE619664 BE465887 AA745605 AI278924 AI278546 A280994 AA809678 AA282134 T08599 AA732436 T05478 F04402 AA262267 Api969523 N25559 Api760218 BG217318 BF893160 419308 249928 1 N40321 AA236322 AA236215 446152 2857941 1 A1292036 A1858546 A1277390 449092 4406_1 AK056270 AV706896 AI692935 AI681140 AWi62481 AW087114 AW157019 AI689795 AW251085 AW206911 BF438207 AW134945 BE041668 BF111425 U91641 NMJ) 13305 BF968902 U55966 AU1307W BE174853 AI929731 AW161524 R43753 BE779688 TABLE 49C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham. et al.'refers to the publication entitled'The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted.

Ntposifon : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 402075 8117407 Plus 121907-122035, 122804-122921, 124019-12416 405451 7622517 Minus 145949-146227 401747 9789672 Minus 118596-118816, 119119-119244, 119609-11976 401454 9186923 Minus 114659114832 405545 1054740 Plus 118677-118807, 119091-119296, 121626-12182 401780 7249190 Minus 28397-28617, 28920-29045, 29135-29296. 2941 403328 8469086 Minus 120428-120703 405547 1054740 Plus 124361-124520, 124914-125050 403532 8076842 Minus 81750-81901 400750 8119067 Plus 198991-199168, 199316-199548 405506 6466489 Plus 80014-80401, 80593-81125 400533 6981826 Minus 277132-277595 405779 7280331 Minus 33048-33856 402994 2996643 Minus 4727-4969 401781 7249190 Minus 83215-83435, 83531-83656, 83740-83901, 8423 401994 4153858 Minus 42904-43124. 43211-43336, 44607-44763. 4519 403969 8569909 Plus 31237-31375, 32405-32506 401760 9929699 Plus 83126-83250, 85320-85540, 9471995287 401797 6730720 Plus 6973-7118 401151 9438288 Plus 30848-31228 404872 9650523 Minus 18540-18718 402876 9864669 Plus 5679-6027, 74857584 405204 7230116 Plus 126569-126754 402294 2282012 Minus 2575-3000 400991 8096825 Plus 159197-159320 401284 9800819 Minus 101307-101421 402474 7547175 Minus 53526-53628, 5575555920, 57530-57757 403022 3132351 Plus 92097-92864 402542 9801558 Minus 67076-67594 403409 9438598 Plus 6860-7054, 12573-12771 403506 7596863 Plus 105008-105650 406016 8272661 Plus 41341-41940 405268 4156151 Minus 24404-24521 401106 8568931 Plus 122694-122893 404186 4481839 Plus 8291110 403817 8962065 Plus 110297-111052 406422 9256411 Plus 163003-163311 402160 8516165 Plus 166063-166354 402622 9930984 Minus 129861-130099 401558 7139678 Plus 103510-104090 404960 7408010 Minus 14618&146377, 147747-147943 401203 9743387 Minus 172961-173056, 173868-173928 402860 9588237 Minus 76423-76560 401588 7230871 Plus 46412-46561 404831 6624702 Minus 16833-17020, 20007-20120, 21605-21799, 2333 405885 7677703 Minus 42574-42998 TABLE 50A : ABOUT 398 GENES UPREGULATED IN PRIMARY MELANOMAS OR MELANOMA METASTASES RELATIVE TO BENIGN NEVI Table 50A lists about 398 genes upregulated in primary melanoma or melanoma metastases relative to benign nevi. Genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tipe : Unigene gene 6f e R1 : 70th percentile of primary melanoma and melanoma metastasis Als divided by the maximum Al of benign nevi. R2 : 70th percentile of primary melanoma and melanoma metastasis Als divided by the maximum Al of benign nevi, where the 15th percentage of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 422424 A1186431 Hs. 296638 prostate differentiation factor 13. 73 16. 82 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponUn, 11. 67 11. 84 407846 AA426202 Hs. 40403 Cbp/p300-interacGng transactivator, wit 9. 35 7. 59 444381 BE387335 Hs. 283713 ESTs, Weakly similar to S64054 hypotheti 8. 63 7. 90 417880 BE241595 Hs. 82848 selectin L (lymphocyte adhesion molecule 8. 21 4. 09 424321 W74048 Hs. 1765 lymphocyte-specific protein tyrosine kin 7. 13 6. 10 447210 AF035269 Hs. 17752 phosphatidylsenne-specificphospholipas 6. 79 6. 26 417693 AW959741 Hs. 40368 adaptor-related protein complex 1, sigma 6. 55 6. 36 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactin) 6. 43 7. 11 414812 X72755 Hs. 77367 monokine induced by gamma interferon 6. 43 7. 51 451736 AW080356 Hs. 23889 ESTs, Weakly similar to ALU7 HUMAN ALU S 6. 31 4. 28 418870 AF147204 Hs. 89414 chemokine (C-X-C motif), receptor 4 (fus 6. 20 4. 32 428291 AA534009 Hs. 183487 interferon stimulated gene (20kD) 6. 03 4. 52 417308 H60720 Hs. 81892 KIAA0101 gene product 6. 01 6. 78 448569 BE382657 Hs. 21486 signal transducer and activator of trans 5. 99 7. 51 439310 AF086120 Hs. 102793 ESTs 5. 95 4. 79 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 5. 95 5. 55 422241 Y00062 Hs. 170121 protein tyrosine phosphatase, receptor t 5. 76 4. 82 442379 Nom004613 Hs. 8265 transglutaminase 2 (C polypeptide, prote 5. 76 2. 19

409274 NM_003930 Hs. 52644 SKAP55 homologue 5. 65 4. 63 442739 NM 007274 Hs. 8679 cytosolic acyl coenzyme A thioester hydr 5. 58 3. 41 442711 AF151073 Hs. 8645 hypothetical protein 5. 45 5. 79 425118 AU076611 Hs. 154672 methylene tetrahydrofolate dehydrogenase 5. 42 5. 56 412918 BE563957 acbvatedRNApolymerasellLranscrip60 5. 35 4. 31 428125 AA393071 Hs. 182579 leucine aminopep6dase 5. 33 4. 83 446921 AB012113 Hs. 16530 small inducible cytokine subfamily A (Cy 5. 33 5. 13 431183 NM 006855 Hs. 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic retic 5. 30 6. 27 414219 W20010 Hs. 75823 ALL1-fusedgenefromchromosome1q 5.'6 5. 13 426600 NM 003378 Hs. 171014 VGF nerve growth factor inducible 5. 05 13. 72 415444 BE247295 Hs. 78452 solutecamerfamily20 (phosphatebran 5. 03 4. 93 436701 AW959032 ESTs, Moderately similar to 178885 serin 5. 03 3. 42 406648 AA563730 Hs. 277477 major histocompa6bility complex, class 4. 99 3. 36 410850 AW362867 Hs. 302738 HomosapienscDNA : FLJ21425 fis, clone C 4. 98 5. 30 418299 AA279530 Hs. 83968 integrin, beta 2 (antigen CD18 (p95), ly 4. 98 4. 85 432469 AL080084 CGI-100 protein 4. 97 4. 46 404854 Target Exon 4. 85 3. 49 415701 NM 003878 Hs. 78619 gamma-glutamyl hydrolase (conjugase, fol 4. 82 4. 90 425397 J04088 Hs. 156346 topoisomerase (DNA) ! 1 alpha (170kD) 4. 81 5. 26 408958 T99607 Hs. 49346 signal recognition particle 54kD 4. 78 2. 34 453949 AU077146 Hs. 36927 hea shock 105kD 4. 78 5. 18 458079 Api796870 Hs. 54277 DNA segment on chromosome X (unique) 992 4. 77 4. 13 440245 AK001913 Hs. 7100 hypothetical protein 4. 74 3. 32 412228 AW503785 Hs. 73792 complement component (3d/EpsteinBarrvi 4. 74 1. 55 417834 BE172058 Hs. 82689 tumor rejection antigen (gp96) 1 4. 73 4. 25 451003 AF058696 Hs. 25812 Nijmegen breakage syndrome 1 (nibrin) 4. 67 4. 69 424571 BE379766 polymerase (RNA) II (DNA directed) polyp 4. 62 3. 02 434203 BE262677 Hs. 283558 hypotheticalprotein PR01855 4. 61 5. 45 452268 NM_003512 Hs. 28777 H2A histone family, member L 4. 60 2. 88 421311 N71848 Hs. 283609 hypothetical protein PR02032 4. 60 3. 24 410491 AA465131 Hs. 64001 Homo sapiens clone 25218 mRNA sequence 4. 60 4. 34 425706 AW406678 Hs. 122559 hypothetical protein FW22570 4. 59 3. 58 450293 N36754 Hs. 171118 hypothetical protein FU00026 4. 57 3. 82 406836 AW514501 Hs. 156110 immunoglobulin kappa constant 4. 57 9. 27 413441 A1929374 Hs. 75367 Src-like-adapter 4. 53 3. 60 431129 AL137751 Hs. 263671 Homo sapiens mRNA ; cDNADKFZp43410812 (f 4. 48 4. 89 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 4. 47 3. 72 411060 NM_006074 Hs. 318501 HomosapiensrnRNAhulllengthinsericDN 4. 47 3. 96 417501 AL041219 Hs. 82222 semadoman, immunoglobúlindomain (lg), 4. 45 2. 40 437763 AA469369 Hs. 5831 tissue inhibitor of metalloproleinae 1 4. 43 4. 27 448883 BE614989 Hs. 7503 hypothetical protein FU14153 4. 42 3. 91 417274 N92036 Hs. 81848 RAD21 (S. pombe) homolog 4. 41 3. 80 419285 D31887 Hs. 89868 KIAA0062 protein 4. 40 3. 20 418321 D63477 Hs. 84087 KIAA0143 protein 4. 38 2. 79 430154 AW583058 Hs. 234726 serine (orcysteine) proteinaseinhibito 4. 37 3. B6 428450 NM014791 Hs. 184339 KIAA0175 gene product 4. 36 4. 65 428297 AA236291 Hs. 183583 serine (or cysteine) proteinase inhibito 4. 36 3. 42 447232 AW499834 Hs. 327 interleukin 10 receptor, alpha 4. 36 3. 31 409598 NM014018 Hs. 55097 mitochondrial ribosome protein S28 4. 35 3. 10 442432 BE093589 Hs. 38178 hypothetical protein FLJ23468 4. 34 5. 61 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 4. 33 3. 31 443991 NM002250 Hs. 10082 potassiumintennediate/smallconductance 4. 33 3. 57 452322 BE566343 Hs. 28988 glutaredoxin (thioltransferase) 4. 32 2. 20 420991 AW504814 Hs. 287379 HomosapiensmRNAforFW00111 protein, 4. 32 3. 60 449722 BE280074 Hs. 23960 cyclin B1 4. 31 5. 79 408380 AF123050 Hs. 44532 diubiquitin 4. 30 3. 62 427127 AW802282 Hs. 22265 pyruvate dehydrogenase phosphatase 4. 28 4. 18 417933 X02308 Hs. 82962 thymidylate synthetase 4. 28 5. 06 432828 AB042326 Hs. 287402 chondroitin 4-sulfotransferase 4. 25 4. 15 450306 AL080080 Hs. 24766 thioredoxin domain-containing 4. 24 3. 15 440266 AA088809 Hs. 19525 hypothetical protein FU22794 4. 23 3. 65 407951 W77762 Hs. 79015 antigen identified by monoclonaf an6bod 4. 22 4. 21 427337 Z46223 Hs. 176663 FcfragmentoflgG, lowafinitylllb, r 4. 20 4. 11 408989 AW361666 Hs. 49500 KIAA0746 protein 4. 20 4. 26 449626 AA774247 Hs. 301637 zinc finger protein 258 4. 19 2. 65 422846 BE513934 Hs. 1583 neutrophil cytosolic factor 1 (47kD, chr 4. 18 6. 80 415726 T89844 Hs. 78712 aminolevulinate, delta-, synthase 1 4. 16 4. 28 444207 Al565004 cathepsinD (lysosomalapatylproteae 4. 16 1. 89 416980 AA381133 Hs. 80684 high-mobilitygroup (nonhistonechromoso 4. 14 3. 32 438718 AL040058 Hs. 6375 uncharactedzed hypothalamus protein HTO 4. 14 3. 02 437802 A1475995 Hs. 122910 ESTs 4. 12 4. 18 446392 AF142419 Hs. 15020 homolog of mouse quaking QKI (KH domain 4. 12 3. 87 409461 AA382169 Hs. 54483 N-myc (and STAT) interactor 4. 11 3. 80 427247 AW504221 Hs. 174103 integrin, alphaL (antigenCD11A (p180), 4. 11 5. 71 414359 M62194 Hs. 75929 cadherin)). ; ype2. 0B-cadhenn (osteob 4. 10 4. 25 450071 AA08283 Hs. 24359 Homo sapiens cDNA FLJ 11174 fis, clone PL 4. 10 2. 91 452882 AW972990 Hs. 196270 folate transporterkarner 4. 10 4. 25 414522 AW518944 Hs. 76325 Immunoglobulin J chain 4, 09 3. 99 407756 AA116021 Hs. 38260 ubiquitin specific protease 18 4, 09 4. 60 405506 Target Exon 4. 08 3. 64 444677 AL110212 Hs. 301005 purine-rich element binding protein B 4. 07 2. 43 417497 AW402482 Hs. 82212 CD53 antigen 4. 07 6. 55 413715 AW851121 Hs. 75497 Homo sapiens cDNA : FLJ22139 fis, clone H 4. 06 3. 27

421508 NM 004833 Hs. 105115 absent in melanoma 2 4. 05 4. 39 408688 A1634522 Hs. 152925 K1AA1268 protein 4. 05 3. 32 439453 BE264974 Hs. 6566 thyroid hormone receptor interact 13 4. 04 3. 53 445701 AF055581 Hs. 13131 lymphocyte adaptor protein 4. 02 4. 20 451131 Api267586 Hs. 268012 fatty-acid-Coenzyme A ligase, long-chain 4. 01 3. 96 449291 BE176893 Hs. 23440 KIAAt 105 protein 4. 01 2. 34 443071 AL080021 Hs. 8986 complement component 1, q subcomponent, 4. 00 6. 97 417615 BE548641 Hs. 82314 hypoxanthinephosphoribosyitransferaset 3. 99 4. 27 408246 N55669 Hs. 333823 mitoehondriafnbosoma) protein L13 3. 98 3. 66 408819 AW163483 Hs. 48320 doublenng-ñngerprotein, Dorfin 3. 98 3. 76 424058 AL121516 Hs. 138617 thyroid homione receptor interactor 12 3. 97 2. 38 418942 AJ566004 Hs. 141269 Homo sapiens cDNA : FLJ21550 fis, clone C 3. 97 3. 40 424756 AW504657 Hs. 152931 lamin B receptor 3. 93 2. 67 421958 AA357185 Hs. 109918 ra homolog gene family, member H 3. 89 2. 39 440692 AL031591 Hs. 7370 phospho6dylinositol transfer protein, b 3. 88 3. 23 433001 AF217513 Hs. 279905 doneHQ0310PR00310p1 3. 88 4. 24 418255 AW135405 Hs. 37251 ESTs 3. 87 2. 53 444371 BE540274 Hs. 239 forkhead box M1 3. 86 4. 29 450515 AW304226 biphenyl hydnolae-like (serine hydrdas 3. 85 3. 73 416114 A1695549 Hs. 183868 glucuronidase, beta 3. 85 3. 74 440596 H13032 Hs. 103378 hypotheUcalproteinMGC11034 3. 84 1. 90 417020 T78413 heterogeneous nudearribonudeoprotein 3. 82 2. 04 448503 BE243146 Hs. 21332 BTB (POZ) domain containing 1 3. 81 3. 07 446506 At123118 Hs. 15159 chemokine-like factor, attematively spl 3. 81 3. 69 417059 AL037672 Hs. 81071 extracellular matrix protein 1 3. 80 6. 01 410668 BE379794 Hs. 159651 hypothetical protein 3. 80 5. 22 420107 AL043980 Hs. 7886 pellino (Drosophila) homolog 1 3. 79 3. 93 446071 N51527 Hs. 13659 hypothetical protein DKFZp586F2423 3. 79 2. 74 419731 S47242 Hs. 92909 SON DNA binding protein 3. 77 1. 85 443710 A1928136 Hs. 9691 Homo sapiens cDNA : FU23249 fis. clone C 3. 77 4. 98 406837 R70292 Hs. 156110 immunoglobulin kappa constant 3. 77 7. 42 436481 AA379597 Hs. 5199 HSPC150 protein simitartoubiquitin-con 3. 76 3. 55 419381 AB023420 Hs. 90093 heat shock 70kD protein 4 3. 76 3. 81 423979 AF229181 Hs. 136644 CSbox-containingWDprotein 3. 76 3. 97 402474 Nom-004079 : Homo sapiens cathepsin S (CTSS 3. 76 4. 01 412828 AL133396 Hs. 74621 prion protein (p27-30) (Creutzfeld-Jakob 3. 75 3. 77 454080 A1199711 Hs. 576 fucosidase, alpha-L-1, tissue 3. 74 6. 15 408085 N25929 Hs. 342849 ADP-ribosylation factor-like 5 3. 74 2. 92 426096 D87436 Hs. 166318 lipin 2 3. 72 2. 98 417105 X60992 Hs. 81226 CD6 antigen 3. 72 2. 78 418322 AA284166 Hs. 84113 cyclin-dependentkinaeinhibitor3 (CDK 3. 72 3. 37 447735 AA775268 Hs. 6127 Homo sapiens cDNA : FU23020 fis, clone L 3. 70 4. 09 409264 NM_014937 Hs. 52463 KIAA0966 protein 3. 69 4. 79 429170 NM001394 Hs. 2359 dual specificity phosphatase 4 3. 69 2. 94 428398 Al249368 Hs. 98558 ESTs 3. 68 3. 82 423494 AW504365 Hs. 24143 Wiskott-Aldrich syndrome protein interac 3. 67 3. 52 413235 BE243445 Hs. 75248 topoisomerase (DNA) 11 beta (180kD) 3. 67 2. 79 423712 W46802 Hs. 81988 disabled (Drosophila) homolog 2 (mitogen 3. 66 3. 42 409703 NM_006187 Hs. 56009 2'-5-oligoadenylate synthetase 3 (100 k 3. 66 6. 44 447225 R62676 Hs. 17820 Rho-associated, coiled-coil containing p 3. 65 2. 93 414829 AA321568 Hs. 77436 pleckstrin 3. 65 2. 30 400219 Eos Control 3. 64 2. 76 437239 AW503395 Hs. 5541 ATPase, Ca transporting, ubiquitous 3. 63 2. 73 422445 M23114 Hs. 1526 ATPase, Ca transporting, cardiac muscle, 3. 62 3. 60 449971 AA807346 Hs. 288581 Homo sapiens cDNA FLJ14296 fis, clone PL 3. 62 3. 62 424460 BE275979 Hs. 296014 polymerase (RNA) ll (DNA directed) polyp 3. 62 3. 06 427609 AK000436 Hs. 179791 hypothetical protein FLJ20429 3. 62 2. 31 400750 Target Exon 3. 61 2. 74 424541 AW392551 Hs. 180559 ESTs, Weakly similar to A56194 thromboxa 3. 61 2. 25 427051 BE178110 Hs. 173374 Homo sapiens cDNA FLJ 10500 fis, clone NT 3. 60 4. 20 433867 AK000596 Hs. 3618 hippocåcin-like 1 3. 59 4. 19 421986 AL137438 Hs. 110454 SEC15 (S. cerevisiaeylike 3. 59 1. 58 414841 H55601 Hs. 77490 glutathione S-transérase theta 1 3. 58 1. 00 429693 BE254962 Hs. 211612 SEC24 (S. cerevisiae) elatedgenefamil 3. 57 3. 00 425204 Nu-002436 Hs. 1861 membrane protein, palmitoylated 1 (SSkD) 3. 56 3. 09 441669 R78195 Hs. 29692 HomosapienscDNAFW11436fis, cloneHE 3. 56 3. 26 442043 BE567620 Hs. 99210 ESTs 3. 55 3. 56 406636 L12064 gb : Homo sapiens (clone WR4. 12VL) anti-th 3. 55 3. 83 446341 AL040763 Hs. 310735 ESTs, Moderately similar to ALU7 HUMAN A 3. 54 3. 52 432485 N90866 Hs. 276770 CDW52 antigen (CAMPATH-1 antigen) 3. 54 4. 66 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur 3. 54 3. 25 412630 AA738437 Hs. 26226 HomosapienscDNA FW21286fis, cloneC 3. 54 1. 87 432841 M93425 Hs. 62 protein tyrosinephosphatase. non-recept 3. 53 3. 96 425177 AF127577 Hs. 155017 nudearreceptorinteracting protein 1 3. 53 3. 40 426643 AA857131 Hs. 171595 HIV TAT specific factor 1 3, 51 2. 21 420137 AA306478 Hs. 95327 CD3D antigen, delta polypeptide (TiT3 co 3 51 2. 51 429248 U96759 Hs. 198307 von Hippel-Lindau binding protein 1 3. 51 2. 85 452852 AK001972 Hs. 30822 hypotheticalproteinFFJ11110 3. 51 2. 71 451791 Z78407 Hs. 27023 vesicle transport-related protein 3. 49 2. 91 418310 AA814100 Hs. 86693 ESTs 3. 49 1. 45 406868 AA505445 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 3. 48 6. 81 400200 NM002788' : Homo sapiens proteasome (pros 3. 48 2. 51 438746 A1885815 Hs. 184727 Human melanoma-associated antigen p97 (m 3. 47 6. 94

441646 AB023169 Hs. 7935 KIAA0952 protein 3. 47 3. 38 427968 A) 857607 Hs. 181301 cathepsin S 3. 45 2. 71 440201 AL359588 Hs. 7041 hypothetical protein DKFZp762B226 3. 45 3. 45 434608 AA805443 Hs. 179909 hypothetical protein FU22995 3. 44 3. 68 427527 At809057 Hs. 153261 immunoglobulin heavy constant mu 3. 44 6. 70 413385 M34455 Hs. 840 indoleamine-pynrole23dioxygenae 3. 44 2. 72 435550 Api224456 Hs. 324507 H. sapiens polyA site DNA 3. 43 2. 76 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 3. 43 3. 64 423392 AA195037 Hs. 169341 HTPAP protein 3. 43 2. 29 418460 M26315 Hs. 85258 CD8 antigen, atpha polypeptide (p32) 3. 43 2. 78 453915 AA588721 Hs. 286218 ribosomal protein L44 3. 41 3. 06 442485 BE092285 Hs. 29724 hypothetical protein FLJ13187 3. 41 4. 23 432606 NM 002104 Hs. 3066 granzyme K (serine protease, granzyme 3 ; 3. 40 3. 93 417410 AF063020 Hs. 82110 PC4 and SFRS1 interacting protein 1 3. 40 2. 12 436810 AA353044 Hs. 5321 ARP3 (actin-related protein 3, yeast) ho 3. 40 4. 70 422545 X02761 Hs. 287820 fibronectin 1 3. 39 7. 58 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 3. 36 4. 12 434826 AF155661 Hs. 22265 pyruvate dehydrogenase phosphatase 3. 34 5. 05 448410 AK000227 Hs. 21126 hypothetical protein FLJ20220 3. 33 4. 31 416065 BE267931 Hs. 78996 proliferating cell nuclear antigen 3. 33 4. 60 432642 BE297635 Hs. 3069 heat shock 70kD protein 9B (mortalin-2) 3. 32 4. 49 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypotheb 3. 24 4. 22 443623 AA345519 Hs. 9641 complement component 1, q subcomponent 3. 23 12. 31 426490 NM_001621 Hs. 170087 aryl hydrocarbon receptor 3. 23 5. 07 443958 BE241880 Hs. 10029 cathepsin C 3. 16 4. 97 412577 Z22968 Hs. 74076 CD163 antigen 3. 14 4. 75 414050 NM 004766 Hs. 75724 coatomer protein complex, subunit beta 2 3. 13 4. 00 421633 AF121860 Hs. 106260 sorting nexin 10 3. 12 4. 45 413936 AF113676 Hs. 297681 serine (or cysteine) proteinase inhibito 3. 11 4. 00 428797 AA496205 Hs. 193700 Homo sapiens mRNA ; cDNADKFZp58610324 (f 3. 10 4. 03 430314 AA369601 Hs. 239138 pre-B-cell colony-enhancing factor 3. 06 4. 49 430413 AW842182 Hs. 241392 small inducible cytokine A5 (RANTES) 3. 04 4. 98 418526 BE019020 Hs. 85838 solutecanierfamily16 (monocarboxylic 3. 03 4. 49 452139 AA099969 Hs. 16331 Homo sapiens cDNA : FLJ21482 fis, clone C 3. 01 4. 75 439237 AW408158 Hs. 318893 ESTs, Weakly similar to A47582 B-cell gr 2. 95 5. 55 422684 BE561617 Hs. 119192 H2A histone family, member Z 2. 94 4. 64 406782 AA430373 gb : zw20fi l. si Soares ovary tumor NBHOT H 2. 93 10. 28 438549 BE386801 Hs. 21858 trinucieotide repeat containing 3 2. 91 5. 40 450455 AL117424 Hs. 25035 chloride intracellular channel 4 2. 90 4. 86 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 2. 89 4. 04 422530 AW972300 Hs. 118110 bone marrow stromal cell antigen 2 2. 87 9. 61 423605 AF047826 Hs. 129887 cadherin 19, type 2 2. 83 4. 86 410231 AA314163 Hs. 61153 proteasome (prosome, macropain) 26S subu 2. 82 5. 02 419956 AL137939 Hs. 40096 cadherin 19, type 2 2. 80 4. 30 416511 NMJM6762 Hs. 79356 Lysosomal-associated mulGspanning membr 2. 79 5. 80 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2 doma 2. 78 4. 21 448517 AA082750 Hs. 42194 hypothetical protein FLJ22649 similar to 2. 78 4. 23 416784 AA334592 Hs. 79914 tumican 2. 78 4. 40 427792 M63928 Hs. 180841 tumor necrosis factor receptor superfami 2. 77 4. 23 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 2. 77 4. 17 427080 AW068287 Hs. 301175 ras-related C3 botulinum toxin substrate 2. 76 4. 43 446272 BE268912 Hs. 14601 hematopoietic cell-specific Lyn substrat 2. 75 4. 20 437179 AA393508 serologically defined colon cancer antig 2. 74 4. 07 429402 AF116571 Hs. 201671 SRY (sexdeterminingegionY>box13 2. 72 4. 63 421360 AA297012 Hs. 103839 erythrocyte membrane protein band 4. 1-li 2. 71 4. 93 409202 AA236881 Hs. 51043 hexosaminidase (betapotypeptide) 2. 68 4. 15 426124 AI268389 Hs. 250697 phosphabdylinositol glycan, class F 2. 68 4. 00 422672 X12784 Hs. 119129 collagen, type IV, alpha 1 2. 67 4. 72 417389 BE260964 Hs. 82045 midkine (neurite growth-promo6ng factor 2. 65 7. 77 409415 AA579258 Hs. 6083 Homo sapiens cDNA : FLJ21028 fis, clone C 2. 65 4. 47 410341 AW499985 Hs. 42915 ARP2 (actin-related protein 2, yeast) ho 2. 64 5. 61 433027 AF191018 Hs. 279923 putative nucleotide binding protein, est 2. 63 4. 34 424687 J05070 Hs. 151738 matrix metalloproteinase 9 (gelatinase B 2. 62 4. 95 409430 R21945 Hs. 346735 splicing factor, arginine/serine-rich 5 2. 60 6. 00 424779 AL046851 Hs. 153053 CD37 antigen 2. 60 4. 27 409354 N68188 Hs. 159472 Homo sapiens cDNA : FLJ22224 fis, clone H 2. 60 4. 64 427550 BE242818 Hs. 311609 nuclearRNAhelicase, DECDvaiantofDE 2. 57 4. 27 426143 BE379836 proteasome (prosome, macropain) subunit 2. 56 4. 20 421563 Nom-006433 Hs. 105806 granulysin 2. 56 4. 13 425593 AA278921 Hs. 1908 proteogtycanl. secretory granule 2. 55 5. 46 428169 Ai928984 Hs. 182793 golgi phosphoprotein 2 Z54 5. 78 429800 AA333375 Hs. 223014 antizyme inhibitor 2. 50 5. 15 407241 M34516 gb : Human omega light chain protein 14. 1 2. 50 4. 98 421739 AB004550 Hs. 107526 UDP-Gal : belælcNAc beta 1, 4- galactosylt 2. 45 5. 58 412819 T25829 Hs. 24048 FK506 binding protein precursor 2. 45 7. 20 412025 A1827451 Hs. 24143 Wiskod-Alddch syndrome protein interac 2. 44 4. 11 435523 T62849 Hs. 11090 membrane-spanning4-domains, subfamilyA 2. 44 4. 67 445350 AF052112 Hs. 12540 lysophospholipase 1 2. 44 5. 44 449296 AL137257 Hs. 23458 Homo sapiens cDNA : FU23015 fis, clone L 2. 41 4. 31 440065 W03476 Hs. 266331 hypothetical protein MGC4595 2. 41 4. 25 400223 Eos Control 2. 39 5. 68 422658 AF231981 Hs. 250175 homolog of yeast long chain polyunsatura 2. 39 6. 62 431629 AU077025 Hs. 265827 interferon, alpha-inducible protein (clo 2. 38 7. 22

414622 AI752666 Hs. 76669 nicotinamide N-methyltransferase 2. 38 5. 21 415149 X12451 Hs. 78056 cathepsin L 2. 37 7. 71 435099 AC004770 Hs. 4756 flap structure-specific endonuclease 1 2. 37 5. 68 427407 BE268649 Hs. 177766 ADP-ribosylUansferase (NAD ; poly (ADP-r 2. 31 4. 89 426432 AF001601 Hs. 169857 paraoxonase 2 2. 29 4. 83 430555 Al815486 Hs. 243901 Homo sapiens cDNA FW20738 fis, done HE 2. 27 5. 03 413869 NM_000878 Hs. 75596 interleukin 2 receptor, beta 2. 25 4. 14 412617 AK001364 Hs. 808 heterogeneous nuclear ribonucleoprotein 2. 21 4. 31 447547 NM 007229 Hs. 18842 protein kinase C and casein kinase subst 2. 19 4. 62 416232 AW502678 Hs. 79090 exporUn 1 (CRM1, yeasL homolog) 2. 18 4. 84 420842 Al083668 Hs. 50601 hypothetical protein MGC10986 2. 14 4. 22 411358 R47479 Hs. 94761 KIAA1691 protein 2. 13 4. 65 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 2. 13 4. 03 406687 M31126 maNx metalloproteinase 11 (sUromelysin 2. 11 4. 16 417331 AW411297 Hs. 81972 SHC (Src homology 2 domain-containing) t 2. 11 4. 25 450344 AW994032 Hs. 8768 hypothetical protein FLJ 10849 2. 11 4. 09 429642 X68264 Hs. 211579 melanoma cell adhesion molecule (MCAM) (2. 11 5. 42 416448 L13210 Hs. 79339 pectin, galactoside-binding, soluble, 3 2. 10 6. 42 418613 AA744529 Hs. 86575 mitogen-acfivated protein kinase kinase 2. 10 4. 00 453352 T10446 ESTs 2. 09 4. 48 409220 BE243323 Hs. 51233 tumor necrosis factor receptor superfami 2. 09 4. 98 414045 NM 002951 Hs. 75722 ribophorin 11 2. 07 4. 59 422451 AA310753 Hs. 42491 ESTs, WeaklysimilartoS65657åpha-1C-2. 07 4. 09 414085 AA114016 Hs. 75746 aldehyde dehydrogenase 1 family, member 2. 06 5. 06 452363 A1582743 Hs. 94953 Homo sapiens, Similar to complement comp 2. 04 11. 17 438393 AA351815 Hs. 50740 Homo sapiens cDNA : FU22272 fis, clone H 2. 03 4. 36 413313 NM002047 Hs. 283108 glycyl-tRNA synthetase 2. 02 4. 79 412994 D32257 Hs. 75113 general transcription factor IIIA 2. 00 4. 67 424415 Nom-001975 Hs. 146580 enolase 2, (gamma, neuronal) 1. 98 4. 79 421897 AW583693 Hs. 109253 N-temminalæetyltransferasecomplexad 1. 98 4. 17 442159 AW163390 Hs. 278554 heterochromatin-like protein 1 1. 95 7. 53 429451 BE409861 Hs. 202833 heme oxygenase (decycling) 1 1. 95 4. 63 416967 BE616731 Hs. 80645 interferon regulatory factor 1 1. 95 4. 31 400203 Eos Control 1. 94 5. 03 437317 AA748613 Hs. 311977 ESTs, Highly similar to SWI/SNF related, 1. 94 4. 03 414945 BE076358 Hs. 77667 lymphocyte antigen 6 complex, locus E 1. 93 4. 68 416224 NM2902 Hs. 79088 reticulocalbin 2, EF-hand calcium bindin 1. 92 4. 12 445411 AL137255 Hs. 12646 hypothe6cal protein FU22693 1. 91 4. 23 413945 NM 000591 Hs. 75627 CD14 antigen 1. 90 5. 00 413317 U53225 Hs. 75283 sorting nexin 1 1. 89 4. 20 448719 AA033627 Hs. 21858 binuclediderepealcontåning3 1. 89 4. 26 430838 N46664 Hs. 169395 hypothetical protein FU12015 1. 88 4. 15 427239 BE270447 ubiquitin carrier protein 1. 87 5. 72 450440 AB024334 Hs. 25001 tyrosine 3-monooxygenase/tryptophan 5-mo 1. 87 5. 81 433671 AW138797 Hs. 132906 19A24 protein 1. 85 4. 27 413190 AA151802 Hs. 40368 adaptor-related protein complex 1, sigma 1. 85 5. 19 414915 NM 002462 Hs. 76391 myxovirus (influenza) resistance 1, homo 1. 85 4. 31 430040 AW503115 Hs. 227823 pM5 protein 1. 83 5. 57 417929 R27219 Hs. 74647 Human T-cell receptor active alpha-chain 1. 82 4. 29 414570 Y00285 Hs. 76473 insulin-like growth factor 2 receptor 1. 81 4. 39 414416 AW409985 Hs. 76084 hypothetical protein MGC2721 1. 80 4. 20 428977 AK001404 Hs. 194698 cyclin B2 1. 79 4. 17 418707 U97502 Hs. 87497 butyrophilin, subfamily 3, member A2 1. 78 4. 30 425367 BE271188 Hs. 155975 protein tyrosine phosphatase, receptor t 1. 78 5. 44 425811 AL039104 Hs. 159557 karyopherin alpha 2 (RAG cohort 1, impor 1. 77 5. 11 422009 A1742845 Hs. 110713 DEKoncogene (DNAbinding) 1. 77 4. 37 424909 S78187 Hs. 153752 cell division cycle 258 1. 74 5. 00 409154 U72882 Hs. 50842 interferon-induced protein 35 1. 74 4. 86 413892 A1878921 Hs. 75607 myristoylated alanine-rich protein kinas 1. 73 4. 37 444954 AW247076 Hs. 12163 eukaryotictranstation initiation factor 1. 71 5. 02 424263 M77640 Hs. 1757 L1 cell adhesion molecule (hydrocephalus 1. 70 4. 68 424825 AF207069 Hs. 153357 procollagen-lysine, 2-oxoglutarate 5-dio 1. 70 4. 59 427378 BE515037 Hs. 177556 melanoma antigen, family D, 1 1. 67 5. 59 413322 AA380158 Hs. 75290 ADP-nbosyla60nfætor4 1. 67 4. 39 442414 BE408758 Hs. 8297 ribonuclease 6 precursor 1. 65 4. 03 410129 BE244074 Hs. 58831 regulalorof Fa-induced apoptosis 1. 64 4. 24 422976 AU076657 Hs. 1600 chaperonin containing TCP1, subunit 5 (e 1. 64 4. 91 443051 AA333660 Hs. 71331 hypothetical protein MGC5350 1. 64 4. 08 452472 AW957300 Hs. 294142 ESTs, Weakly similar to C55663 oligodend 1. 63 4. 41 446143 BE245342 Hs. 306079 sec61 homolog 1. 62 4. 70 431142 AA852596 Hs. 250641 tropomyosin 4 1. 62 4. 86 407752 AA573581 Hs. 13328 ESTs 1. 62 4. 19 416322 BE019494 Hs. 79217 pyrroline-5-carboxylate reductase 1 1. 61 4. 51 414572 AU077174 Hs. 288181 cathepsin H 1. 60 5. 25 415017 F06434 Hs. 77805 ATPase, H transporting, lysosomal (vacuo 1. 60 4. 56 452056 AW955065 Hs. 101150 Homo sapiens, clone IMAGE : 4054156, mRNA, 1. 58 5. 46 413976 BE295452 Hs. 75655 procoliagen-proline, 2-oxoglutarate 4-di 1. 58 4. 05 414420 AA043424 Hs. 76095 immediate early response 3 1. 58 4. 00 419638 N46504 Hs. 91747 profilin 2 1. 57 5. 57 422624 BE616678 Hs. 76152 KDEL (Lys-Asp-Glu-Leu) endoplasmic reGc 1. 57 4. 44 415819 AU077330 iranscripbonelonga60nfætorA (SII), 1. 55 4. 89 439627 BE621702 Hs. 29076 hypothetical protein FLJ21841 1. 55 6. 66 425243 N89487 Hs. 155291 KIAA0005 gene product 1. 54 4. 38

424799 BE550723 Hs. 153179 fatty acid binding protein 5 (psoriasis-1. 53 4. 22 416971 R34657 Hs. 80658 uncoupling protein 2 (mitochondrial, pro 1. 53 7. 41 426059 BE292842 Hs. 166120 interferon regulatory factor 7 1. 51 4. 12 418879 AW162087 Hs. 5437 Tax1 (human T-cell leukemia virus type 1 1. 50 4. 02 432999 BE294029 Hs. 279903 Ras homolog enriched in brain 2 1. 50 4. 18 415661 AF057307 Hs. 78575 prosaposin (variant Gaucher disease and 1. 49 4. 19 428098 AU077258 Hs. 182429 protein disulfide isomerase-related prot 1. 49 5. 74 452264 AU077013 Hs. 28757 transmembrane 9 superfamily member 2 1. 48 4. 53 415198 AW009480 Hs. 943 natural ldller cell transcript 4 1. 47 4. 95 411794 AL118577 Hs. 75658 phosphorylase, glycogen : brain 1. 45 4. 61 433271 BE621697 Hs. 14317 nucleolar protein family A, member 3 (Hi 1. 45 4. 15 421416 BE302950 Hs. 104125 adenylyl cyclase-associated protein 1. 42 4. 67 415089 N25117 Hs. 299465 ribosomal protein S26 1. 41 5. 19 421975 AW961017 Hs. 6459 hypothetical protein FU11856 1. 41 4. 03 400202 NM 002795' : Homo sapiens proteasome (pros 1. 41 4. 44 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa 1. 41 4. 57 412968 AW500508 Hs. 75102 alanyl-tRNA synthetase 1. 40 4. 25 440704 M69241 Hs. 162 insulin-like growth factor binding prote 1. 39 4. 11 447099 AB030656 Hs. 17377 coronin, actin-binding protein, 1C 1. 39 4. 51 428511 AA019912 Hs. 184693 transcrip60nelonga60nfætorB (SIII) 1. 38 4. 90 413825 BE299181 Hs. 75564 CD151 antigen 1. 37 4. 44 441737 X79449 Hs. 7957 adenosine deaminase, RNA-specfic 1. 36 4. 29 440087 W28969 Hs. 7718 hypotheticai protein FU22678 1. 36 4. 10 413566 AW604451 Hs. 285814 sprouty (Dnosophila) homoiog 4 35 4. 50 413019 BE281604 Hs. 75140 low density lipoprotein-related protein-1. 35 5. 14 433026 AW160616 Hs. 279921 HSPC035 protein 1. 35 4. 14 427380 Nom 005534 Hs. 177559 interferon gamma receptor 2 (interferon 1. 34 4. 35 428289 M26301 Hs. 2253 complement component 2 1. 33 4. 23 419715 AF070523 Hs. 92384 vitamin A responsive ; cytoskeleton relat 1. 32 4. 61 425299 AW505214 Hs. 155560 calnexin 1. 31 4. 76 422242 AJ251760 Hs. 273385 guanine nucleotide binding protein (G pr 1. 30 5. 30 448483 AA356392 Hs. 21321 HomosapienscloneFLB9213PR02474mRNA, 1. 29 6. 09 407143 C14076 Hs. 332329 EST 1. 29 4. 56 413125 BE244589 Hs. 75207 glyoxalase 1 1. 26 5. 56 439053 BE244588 Hs. 6456 chaperonin containing TCP1, subunit 2 (b 1. 26 4. 98 413929 BE501689 Hs. 75617 collagen, type IV, alpha 2 1. 25 4. 76 419663 AA394208 Hs. 92198 calcium-regulated heat-stable protein (2 1. 24 4. 56 422166 W72424 Hs. 112405 S100 calcium-binding protein A9 (calgran 1. 21 8. 96 416636 N32536 Hs. 42645 solutecarrierfamily16 (monocarboxylic 1. 21 4. 02 425335 BE394327 Hs. 296267 fotiistatin-iiket 1. 18 4. 29 446211 A1021993 Hs. 14331 S100 calcium-binding protein A13 1. 17 4. 32 428642 Mot4899 Hs. 10432 KIAA0878 protein 1. 13 4. 17 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 1. 10 4. 00 428216 M18468 Hs. 183037 protein kinase, cAMP-dependent, regulate 1. 09 4. 40 431211 M86849 Hs. 323733 gap junction protein, beta 2, 26kD (conn 1. 00 4. 70 422158 L10343 Hs. 112341 protease inhibitor 3. skin-derived (SKAL 0. 98 4. 40 408522 Ai541214 Hs. 46320 Small proline-dch protein SPRK [human, 0. 90 4. 78 TABLE 50B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 412918 27643 BE784583 AL519009 AV755430 AV756363 AV711927 B1523434 A1521453 AA846815 AW024829 AW949702 BG218926 AA626658 Al445621 Al452815 AA946555 AA723580 AA612925 BG105326 BG532618 AW513994 AW602165 A1373448 AA907901 AW135104 BG186662 W69205 BG219754 BE774875 BG190378 AA483698 BE066066 BE066067 BE066062 AW304207 BE939361 AW795569 BG210592 AW795644 BE939358 AW102886 BE065977 BG182971 H97042 D58090 B1046351 H81248 Al750112 AW372079 C05492 D58287 D57835 AA935095 BF700910 BG215802 BG195459 AW368467 BG495535 BG533177 B1087962 BE541579 BF130753 436701 28142-1 Z69892 AA210833 BM353155 AI473754 AI147901 AI803109 AA843296 AA418925 AI478552 AI400067 AI360304 AA418828 AW301673 BE218952 A1632804 BF433234 AA394157 BF378047 BE467036 AA319724 AW290940 Al222671 Al347724 AW001711 A1028652 AA398130 A1470582 Api915936 AA908929 C75102 N36920 H50440 AI919034 A1004399 AI383862 AN 23606 AA648518 AA516258 AI865321 N22865 AA848101 AI589792 AA758196 AA214630 Ai373911 AW194733 AA213447 A ! 290291 BF437165AA757592 BF086904 AW959032 AW992466 BF446888 A1936337 BE938849 AW149064 A1701629 N90021 432469 58644_1 BC016556 BC016365 NM 016040 AF151858 BI561037 AW966873 AW967497 BE219482 BE018650 AW770511 AW469095 AW470133 BM150181 BM193977 Al824135 Al632346 Al129838 BM147664 Ai292112 BE244667 AA251084 AW503659 BM193866 BM194481 BF446862 AL597435 BF000262 A1824386AI990100 AW087624 M668793 AL080084 Bl335866 Bl820940 BG779242 BM069854 AA282620 AA256771 AW964511 AA451623 H00335 AW370399 AW954201 BM145846 BG111760 A1750065 BG655794 AA564086 BG494071 BM069606 At675331 BE302224 Al476466 Al625980 BM144854 AI184602 AI343932 AW136586 AW029464 Al708651 M824243 BM145917 AA662210 AA825708 A1335858 A1273704 AA662171 N48971 AA976614 A1344537 AA609603 Ai873901 A1859995 AA833589 AA765811 Al150322 Ai926816 BM148634 N98862 AA019347 AA897062 AA831100 N69889 BE243185 AA282179 AA831098 AA112676 A1702407 BG621752 BE006492 AA353202 BG674256 N46921 B1048774 AW300233 BF739890 AW966879 AA393405 BF115146 AA910851 AA013099 N28878 AA287713 BE348728 BG616446 AL599953 AL599952 BF381073 AW505056 AA094735 H03613 AA287714 H27168 R54718 BF792697 AV693603 AV685883 BG619956 BF541504 BF216789 AA319751 BM452652 BF335838 AA280397 BG171509 BF571997 AA490239 AW388161 BE842126 BG165309 N71903 AI955397 Al536898 BE242040 F09718 AA772421 AA450218 M78543 BE241414 AA013098 H00297 AW576477 AW150918 AW591371 AI382711 N71926 H72497 AI285602 AA745055 AI281647 BF377670 T65207 BG532880 BG721680 AA285143 H27167 AW500235 BG494497 BF668899 424571 9758_1 BE379766 AW1526U Al803450 Al564343AI092711 Al140525 AW152156AI620740AI554689 Al161209 Al290242 Al339745 Al374611 Al347388 A1858296 Al140529 At366124 AA493912 AA406235 AA493889 A1057160 AW022264 A1097277 A1144126 A1080051 AA983529 AA860507 N53469 AA843767 N81163 N70628 AA424577 AA983537 BF003004 AA626688 AA235977 A1057152 A1095366 A1095356 AA458646 AW194479 AA150439 A1375272 AW571777 A1359198 AA993793 BE614394 BE738239 AA127883 A1034344 T59504 D81608 AA908704 AW051665 AA382785 AA307208 N24639 Al370715 BE244980 AA548596 AW449675 Ai191008 BF223749 N70752 N22266 Al191012 M028001 Al419106 BF215661 BF591548 BG942356 A1474968 BE858217 BF793358 AV756758 BG483603 A1093724 BF693395 BG545345 At744294 T59549 AA811773 BG499757

444207 9172_3 BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA169357 BE932464 AA514889 AW819039 AW819083 BE843048 Al432496 Al470335 Api247243 BG533994 AA513783 Al887309 M528036 AW972006 AW873028AI924914 Al818810 AW152378 AW084946 Al521413 Ai669583 BE932521 Al581370 BE180238 AW089750 AW771461 AW089714 AI590949 AI811914 AA731056 BF815234 BF911506 AA235803 AA485373 AI735658 AW393133 AW073080 Api707637 BF353320 BE843111 AW819036 AW393135 BG697291 AV648670 AV654332 AV687530 BG566964 Api807430 Al676072 M837010 Al452482 Al625817 AW241750 BE048616 Al290928 Al680714 M485530 BE175687 AV648513 AW130312 A1000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345 A1244948 AA602956 AA483492 AA918178 AW802049 BG675859AV658871 BG678060 Al565004 AW819026 BE843092 AV686437 AV723049 BG616948 Al911647 Al743490 M091096 BE857251 At962074 AA040027 AW769317 AA343477 AA640112 BF876213 R82948 H26425 H82876 BE843095 BE843140 BG536641 BG617830 AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996 A1749532 BE768614 BE857252 BE932516 BE768573 AV657993 AV657777 AV752631 BE774974 T55847 BF095761 BF911511 BE710793 BE180119 BG617338 H45942 T55897 AV657718 BG563497 450515 13638 2 BE295605 Al589870 M847598 Al470122 BF939896 Api304356 BE223045 BF435800 AI394207 AI708171 AW025415 A1079409 AW008420 AW304226 N34543 AW603578 AA526961 AA983631 N99134 AA626645 R45023 AA902417 AW672925 AA449985 AA953982 AW675471 AA010062 N80194 H14620 H28475 H26247 BF333581 AW842369 H06848 H05608 H81745 H15016 R51905 AA860423 Al860304 M876023 417020 74857 1 AK024824 81089104 AL596792 AI880004 BF969921 BE349489 AA843097 AI475644 AW576123 AW731676 AI339951 AI128503 AW243903 BG231992 BG057353 AA987811 AA575927 Api889162 N68847 AA464693 AA962541 AA844323 Al969578 AI830997 AW731626 H77926 AI338984 R24078 All 28953 T88696 AA808038 AA694545 H02091 BF439007 A1189805 A1279912 AA730423 R26552 M455017 Al264219 Al446015 R19187 D51331 T24484 Api522034 AV721528 81056340 BG009879 AW371368 Z36733 BE707682 BG501334 BG180238 BE177547 H48381 BF055495 Al948528 AW994256 BF109394 817046 W58758 H48807 H01994 T78413 BG750345 R24132 N92060 R25367 400219 8366_1 BC003552 L10284 NM 001746 AJ271880 BI834281 BI597016 AU133331 81668332 81463073 8G720694 AL046729 BI460138 BI461052 AV647588 BG823268 AW889757 BE001258 AA312566 AA476446 AU098976 AA312196 BF749977 M94859 AF070646 BG564196 BG623597 AU117332 BG680963 B1667083 AU134542 AU138830 AI761759 BG679882 AA209406 AW512644 AW514813 Al570535 BE547592 BG655418 Al459204 BF725673 BE870032 BF001968 AL047245 BF724470 BF058818 Hl 8415 BE076849 BE076857 BE076848 BE076827 BE076856 AV708687 AA380923 BE076851 F08118 L18887 BF795701 AU128383 BE908383 AW673350 AW500108 BE079837 BE929419 BF868758 AW503373 AW580528 BE5524 81917505 81457781 BE883812 B1668159 AA213643 AA374821 BF969974 BM480200 AU136152 BE395635 AV685066 AV693755 AL040984 AA676820 BG896408 BE082272 BE082312 C05287 BE082264 AA379850 AW672902 AI625955 BF033526 AW296557 AA728815 BE077058 AW081700 AA911707 AA362640 BE707179 BG913228 BG116191 BG752367 AA074678 AL036937 BG 113760 H03524 BG681802 AI564688 AUt49556 BE178600 A1813488 A1452433 A1206989 AA599392 AA580385 AA486274 AA629899 AA565929 AAl 14046 AA094252 BM450328 BG529968 R68320 BE076792 BE090073 BE076855 BE076859 BE076829AA361719AA379164A) 202712 BG223315 BE122741 BG534531 AA903494 H24978 BF032674 BF085150 BE739158 AA352904 C2t 593 BG697597 M134969 M374612 BE566182 BE871838 BE076911 AW579175 BF966390 Bol548594 BG386452 BG913195 BM456787 N40286 T80096 N39642 H421 19 BG483861 AW381621 R69347 AW128895 AI367416 A1095285 AA099344 BE568161 AA180109 BF246488 Bol561938 AW579170 BG567212 406636 0 0 L12064 L12083 U2065 L12075 L12066 L12085 U2072112 (l82 L12081 L12062 L12080 400200 3806 1 BC005265 BG176720 AW006027 BM352064 AW026316 AI635822 AI880584 AI693769 A1092211 BI492387 AI400449 AW166297 BF939910 AA232282 AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 A1092748 AA993184 AI126077 A1081758 AI240686 AI261863 AI378423 AA465237 AI376096 AA035579 A1087306 AA448162 AA129977 A1090903 A1080686 AI288939 N33004 Al801240 AW021546 Al370773 Al086064 AA669528 AI250053 AIB70113 AA853t 81 AA858014 BG055562 BG939559 AW080765 AA032283 AW467587 H40506 D00762 NM002788 AA641134 A1582295 A1417525 A1563975 A1093566 A1707743 A1290741 AW073417 BE875418 BM264076 BG876884 AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569 BG878291 BG876450 AW819099 AS08570 M449871 AU135228 BM478404 BF126296 AA375499 AA248473 406782 0 0 AA430373 AA968771 437179 12239_1 AK055109 BC019085 AA187684 BG656226 BM023227 Api932311 AW264381 AA398371 BM021483 AI432433 AI375777 AI129580 AW262782 AA134107 BM023515 AA977504 AI859222 AI348454 R69725 AA975268 BM021207 AL080074 AA129218 AW207842 N90581 AA771919 A1092259 A1028416 A1074114 BG656536 BE501677 AW193419 AA917040 W90430 AI342984 AI378957 AL036486 AW020068 81491093 BF476021 R41226 R69631 F04125 C02343 AA115589 R56480 Al400988 R54266 R31422 426143 3806 1 BC005265 8176720 AW006027 BM352064 AW026316 AI635822 AI880584 AI693769 A1092211 BI492387 AI400449 AW166297 BF939910 AA232282 AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 A1092748 AA993184 AI126077 A1081758 AI240686 AI261863 AI378423 AA465237 AI376096 AA035579 A1087306 AA448162 AAi 29977 A1090903 A1080686 AI288939 N33004 AI801240 AW021546 AI370773 A1086064 AA669528 AI250053 AI870113 AA853181 AA858014 BG055562 BG939559 AW080765 AA032283 AW467587 H40506 D00762 NM002788 AA641134 AI582295 AI417525 AI563975 A1093566 AI707743 AI290741 AW073417 BE875418 BM264076 BG876884 Al680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569 BG878291 BG876450 AW819099 AI908570 AA449871 AU135228 BM478404 BFi26296 AA375499 AA248473 400223 2368 1 NM 005648 BC013809 L34587 BF103775 BG702618 BG716553 81667090 BG505863 BF983483 BG718195 Bol857891 BG501016 BM043599 AL521812 BG705730 Bl495545 Bl495546 BF112248 BM023182 BM023123 A1075173 AW051799 BF058224 B1324885 BF436008 AA398446 BG822375 BM019558 BM023382 BG164174 N56909 Bl467064 BM023464AI207475 BM311415 BG758430 BG758807 AI934826 N90351 BG422026 BE910312 Al027778 Al081950 Al360890 BM009115 Al191829 BG759697 Al133728 M399403 Al355589 Al336427 M868702 M393660 M025127 BG027630 AA962774 AA631224 BG940967 BE791087 AA573315 W81685 AA393525 BG944103 AI339125 AI149864 AA977655 N90314 BE612839 Bug491847 AI129091 AA461234 AA781198 AA759256 AA888954 AA975844 AI184099 A1018025 AA398363 A1003331 AI193380 AA626020 AI244476 AI601114 AW135664 Al206607 AW263599 AA813219 AI684453 AA878626 AA772222 A1085496 AI630226 BG940966 A1022010 AA770649 AA887624 AA491739 AA974295 BG530040 AA037091 AA019912 81160457 H64512 BG503896 406687 0_0 M31126 453352 122992 BG619646 AA367158 B) 850421 AW998556 BF107010 BF969630 BF185964 AA361080 AW960026 AA147486 AI807023 AW770262 B1492178 BM145577 AA829932 AW021238 AW629477 AI337862 AI457141 BI712705 BM194542 81712465 AI380070 N27407 Al609764 Al274152 Al206228 A1076874 AI261827 AI610982 AI469158 AI420690 AI168768 AA491615 Ct6249 C16232 C16209 C16275 Ci6274 C16243 R23287 BF246254 R66736 R23212C14593 400203 11774_1 NM_002794 D26599 BM469989 BF305151 BG821966 Bol089030 AW007738 Bl222910 BM049422 BG028749 Al189162 Al831230 AW131497 BM272215 BE791105 AW778828 AA479594 AA480133 AA131997 AA284572 AA453009 BF928258 AAlSZt 27 AA393918 BF765307 BE247542 BF934697 BF341798 BE253409 AA470620 Al8Z8932AW379302 AV762678 AV741784 AV760892 A1025755 AA878562 AA630630 AA761708 AA862518 AA865831 AA862947 N53065 AA131821 AA293499 N23342 N26856 Al147346 AW951549 AA772963 BE245986 BG208493 Api831666 BG474873 Bl023168 AU149647 BG197069 BG191102 BF304178 BE536135 M706900M443583 Al002710AW276192 AU149842 BG214797 BG198193 AW197923 AW627799 T98663 BG194788 BG214656 BF345258 BG716363 A1066528 B1546220 AA393815 AAl 32004 AA353826 H97858 BG187823 BF841463 Api351714 AV735966 BG196439 BG216840 BG198438 BG400762 427239 20459 2 AL532360 BE794750 AA582906 A1015067 AW271034 BG271636 AW075177 AW071374 AI345565 AI307208 BE138953 BE049086 AI334881 AW075006 AW075181 AA464019 AW302733 AW075100 AW073433 A1802854 A1334909 A1802853 A1345036 A1348921 A1340734 A1307478 A1251289 AW302327 AW072520 A1312145 AW073656 AW072513 AW071289 AI307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 AI252926 AI252160 AI251662 AI251262 AI610913 AI270787 AI270156 AI252075 AW073469 AW072901 AW072496AW071420 Al305762Ai254764 Al802837 Al251254 AW073049AW071311 Al340643 BE138965 BE133502 AW073456 Al334733 Al054335 BE139260 Al054302 Al054060 Al054057 Al053722 Al289711 BE139228 AW470478 AW271039 AW302085 BE041872 Al254494 Al271496 Al252427 BF718773 BF718645 AW074866 BE857822 415819 40015_1 BE739429 BM460292 AL549095 BF752457 BE783002 BG035869 AW601528 AI880413 BF593762 AA974415 AW305318 AA716501 Api936239 AI809486 AI744171 AW804992 BF108747AW804693 BE219333 Al807707M306963 BG012140 BF741621 BF741618 BF741619 AW062543 AA155832 AU151381 AU158043 AU150410 AU145605 AU150252 AA188205 AU153035 AI147293 AA084507 AA868165 AI887120 AI468336 AW023112 H44035 F01513 M747672 AW779630 AA757298 R77738 AU150931 R38473 AA189022 H96984 AL550490 AW949737 AU150194 AU149258 Al749453 AW172950 AW276160 Al753604 Al421762 AW575512 AI275633 AW516120 AI340167 AI567728 AI797326 AI471532 A1074080 Api633122 AW674646 AW316571 AA258187 AA102780 AA258186 Al363307 AA862862 AI206836 AA629555 AA486287 AI185097 A1872389 BE465687

A1246746 AI3551453AI189679 AA594582 A1038639 AA862764 AA644332 AA912423 AA601552 AW014502AA694605 AW068949 BF941650 AW297886 BF941649 A1077854 Al027442 M705602 AW020757 BI491734 AA977135 AA653973 81522334 AA398723 AI280083 AI419671 AW009199 AA496011 AU 144081 A1538440 BF741690 BF741680 H41990 AV724108 AW955578 BE698790 T29312 BG954488 R33179 B1832621 BF742040 BE091493 H92122 BG614879 AW993709 AI216562 H44107 AA393530 BE 173154 BG285054 BF751883 AA489308 BF741676 R64496 BEi83198 H97097 AW062534 BF036430 AW192614 BF431707 N30258 AA629072 BG954496 Api401616 BG960957 400202 11771_2 BE873890 BF745945 AA156007 AA573157 AW874610 AA916387 N75963 BM083306 AW044671 BC013008 NM002795 D26598 BG118716 Bl910891 BF972860 BG119842 81094093 AL538757 BE271653 Bol856538 BE909573 BG109826 BE784430 BE899255 Bl833973 BM010809 BE621321 BG684956 BE904726 B1871370AV708990 BF971483 BE298241 B1197007 BE272092 BG120374 AW963509 BE540572 AV744947 BG943041 AW327463 BG472870 BE393697 N28533 AA316042 N42043 AW404246 AW892094 AA379896 AW801110 AW406977 AA379791 BG941889 BE076254 AA360459 AA379385 AA320056 BG942618 D31230AA308300 AA360371 AA371733 AA732937 AA494241 W32225 BF745937 Api383690 BG202360 TABLE 50C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et at.'refers to the publication entitled The DNA sequence of human chromosome 22"Dunham, el al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. NLposi6on : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 404854 7143420 Plus 14260-14537 405506 6466489 Plus 80014-80401, 80593-81125 402474 7547175 Minus 53526-53628, 5575555920. 57530-57757 400750 8119067 Plus 198991-199168, 199316-199548 TABLE 51A : ABOUT 453 GENES UPREGULATED IN PRIMARY MELANOMAS RELATIVE TO NORMAL SKIN Table 51A lists about 453 genes upregulated in primary melanomas relative to normal skin. Genes were selected from 59680 probesets on the EoslAhymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene fifle R1 : 90th percent of primary melanoma Als divided by 90th percent of normal skin Als R2 : 90th percentage of primary melanoma Als divided by 90th percentile of normal skin Als, where the 15th percentile of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 14. 06 15. 56 430377 NM 001922 Hs. 301865 dopachrome tautomerase (dopachrome delta 13. 64 11. 62 426555 Nom-000372 Hs. 2053 tyrosinase (oculocutaneous albinism IA) 13. 50 7. 98 438549 BE386801 Hs. 21858 trinudeotide repeat containing 3 12. 78 13. 80 422424 Al186431 Hs. 296638 prostate differentiation factor 11. 88 15. 56 426600 NM_003378 Hs. 171014 VGF nerve growth factor inducible 10. 14 22. 46 430822 AJ005371 Hs. 248017 glyceraldehyde-3-phosphate dehydrogenase 9. 33 7. 25 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 8. 66 9. 62 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 7. 87 9. 58 417355 D13168 Hs. 82002 endothelin receptor type 8 7. 66 4. 63 447210 AF035269 Hs. 17752 phosphatidytsehne-specificphosphoiipas 7. 38 9. 04 413554 AA319146 Hs. 75426 secetogranin 11 (chromogranin Cì 6. 64 7. 32 415752 BE314524 Hs. 78776 putative transmembrane protein 6. 46 4. 65 421508 NM_004833 Hs. 10511 S absent in melanoma 2 6. 44 7. 00 449644 AW960707 Hs. 148324 ESTs 6. 43 5. 92 426312 AF026939 Hs. 181874 interferon-induced protein with tetratri 6. 27 6. 47 446921 AB012113 Hs. 16530 small inducible cytokine subfamily A (Cy 6. 17 3. 70 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotaclin) 6. 09 3. 92 414812 X72755 Hs. 77367 monokine induced by gamma interferon 6. 04 7. 73 452973 H88409 Hs. 40527 ESTs 6. 04 5. 89 402075 ENSP00000251056' : Plasma membrane calcium 5. 96 2. 50 436856 A1469355 Hs. 127310 ESTs 5. 72 5. 29 425088 AA663372 Hs. 169395 hypothetical protein FW12015 5. 68 5. 88 439310 AF086120 Hs. 102793 ESTs 5. 62 6. 30 429170 Nom-001394 Hs. 2359 dual specificity phosphatase 4 5. 62 3. 30 413670 AB000115 Hs. 75470 hypothetical protein, expressed in osteo 5. 50 4. 28 409512 AW979187 Hs. 293591 melanoma differentiation associated prot 5. 36 4. 14 430540 AW245422 Homo sapiens cDNA : FU22105 fis, clone H 5. 36 4. 64 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 5. 35 4. 31 442426 A1373062 Hs. 332938 hypothetical protein MGC5370 5. 28 4. 03 435056 AW023337 Hs. 5422 glycoprotein M6B 5. 23 3. 25 432828 AB042326 Hs. 287402 chondroitin 4-sulfotransferase 5. 20 5. 52 430294 A1538226 Hs. 32976 guanine nucleotide binding protein 4 5. 14 4. 82 431639 AK000680 Hs. 266175 phosphoprotein associated with GEMs 5. 09 4. 35 430838 N46664 Hs. 169395 hypothetical protein FLJ12015 5. 06 3. 68 414004 AA737033 Hs. 7155 ESTs, Moderately similar to 2115357A TYK 5. 04 4. 23 407366 AF026942 Hs. 17518 gb : Homo sapiens cig33 mRNA, partial sequ 4. 94 6. 29 422192 AA305159 Hs. 113019 fls485 4. 88 5. 62 420208 BE276055 Hs. 95972 silver (mouse horrtolog) like 4. 88 6. 00 446006 NM004403 Hs. 13530 deafness, autosomal dominant 5 4. 77 4. 33 440065 W03476 Hs. 266331 hypothetical protein MGC4595 4. 74 9. 85 421574 AJ000152 Hs. 105924 defensin, beta 2 4. 74 5. 75 440274 R24595 Hs. 7122 scrapie responsive protein 1 4. 72 2. 78 417166 AA431323 Hs. 42146 ESTs 4. 68 4. 29 415314 N88802 Hs. 5422 glycoprotein M6B 4. 65 3. 73 443983 H04482 Hs. 163724 ESTs 4. 64 3. 06

432642 BE297635 Hs. 3069 heat shock 70kD protein 98 (mortalin-2) 4. 62 2. 87 437179 AA393508 serologically defined colon cancer anug 4. 62 5. 08 417933 X02308 Hs. 82962 thymidylate synthetase 4. 58 3. 02 431620 AA126109 Hs. 264981 Z-5-oligoadenylatesynthetae2 (69-71 4. 50 4. 37 431629 AU077025 Hs. 265827 interferon, alpha-inducible protein (clo 4. 49 16. 82 447937 AL109716 Hs. 20034 HomosapiensmRNAhulilengthinsertcDN 4. 44 5. 95 409264 NM 014937 Hs. 52463 KIAA0966 protein 4. 42 2. 94 434203 BE262677 Hs. 283558 hypothetical protein PR01855 4. 42 3. 54 422309 U79745 Hs. 114924 solute carrier family 16 (monocarboxylic 4. 38 3. 30 449722 BE280074 Hs. 23960 cyclin B1 4. 32 4. 07 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osteoponfin, 4. 30 3. 82 450065 AL050107 Hs. 24341 transcdptional co-activator with PDZ-bi 4. 28 4. 36 424247 X14008 Hs. 234734 lysozyme (renal amyloidosis) 4. 27 3. 05 413916 N49813 Hs. 75615 apoWipopnotein C-ll 4. 25 4. 68 420267 N37030 Hs. 173337 ESTs 4. 24 4. 24 442739 NM 007274 Hs. 8679 cytosolic acyl coenzyme A thioester hydr 4. 21 3. 00 433576 BE080715 Hs. 161091 ESTs 4. 20 6. 31 412652 Al801777 ESTs 4. 20 2. 73 438209 AL120659 Hs. 6111 aryt-hydrocarbonreceptornudeartrans ! 4. 20 5. 18 441553 AA281219 Hs. 121296 ESTs 4. 14 4. 94 407856 AA045281 Hs. 266175 phosphoprotein associated with GEMs 4. 14 3. 14 439926 AW014875 Hs. 137007 ESTs 4. 12 4. 76 429903 AL134197 Hs. 93597 cyclin-dependentkinae5, egulatorysu 4. 12 4. 85 400860 Target Exon 4. 10 5. 20 409415 AA579258 Hs. 6083 Homo sapiens cDNA : FLJ21028 fis, clone C 4. 08 6. 02 416636 N32536 Hs. 42645 solute carrier (amily 16 (monocarboxylic 4. 08 2. 42 452826 BE245286 Hs. 301636 peroxisomal biogenesis factor 6 4. 06 Z96 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Grcadian Osciliat 4. 06 2. 28 417632 R20855 Hs. 5422 glycoprotein M68 4. 01 2. 96 418064 BE387287 Hs. 83384 S100caicium-bindingprotein, beta (neur 4. 00 4. 62 448111 AA053486 Hs. 20315 interferon-induced protein with tetratri 4. 00 2. 82 420674 NM_000055 Hs. 1327 butyrylcholinesterase 4. 00 2. 90 451668 Z43948 Hs. 326444 cartilage acidic protein 1 3. 99 5. 17 430015 AW768399 ESTs 3. 96 3. 89 407756 AA116021 Hs. 38260 ubiquitin specific protease 18 3. 94 2. 91 430223 Nom-002514 Hs. 235935 nephroblastoma overexpressed gene 3. 93 3. 89 433364 A1075407 Hs. 296083 ESTs, Moderately similar to 154374 gene 3. 93 4. 70 448719 AA033627 Hs. 21858 tjinucleofide repeat containing 3 3. 92 7. 78 419381 AB023420 Hs. 90093 heat shock 70kD protein 4 3. 87 3. 34 402609 KIAA1209 protein 3. 87 3. 69 408083 BE383668 Hs. 42484 hypothetical protein FLJ10618 3. 86 4. 04 409703 NM006187 Hs. 56009 2-5-oligoadenylate synthetase 3 (100 k 3. 85 3. 64 420218 AW958037 ribosomal protein L4 3. 84 3. 20 434826 AF155661 Hs. 22265 pyruvate dehydrogenase phosphatase 3. 84 5. 19 410600 AW575742 ESTs, Moderately similar to S65657 alpha 3. 82 5. 74 442117 AW664964 Hs. 128899 ESTs ; hypothetical protein for IMAGE : 447 3. 82 2. 96 428513 BE220806 Hs. 184697 Homo sapiens clone 23785 mRNA sequence 3. 82 4. 03 417381 AF164142 Hs. 82042 solute carrier family 23 (nucleobase Ua 3. 80 3. 56 432094 AI658580 Hs. 61426 Homo sapiens mesenchymal stem cell prote 3. 79 3. 23 443105 X96753 Hs. 9004 chondroidn sulfate proteoglycan 4 (mela 3. 77 3. 66 423605 AF047826 Hs. 129887 cadherin 19, bpe 2 3. 72 2. 28 407846 AA426202 Hs. 40403 Cbp/p300-interacting transacGvator, wit 3. 72 5. 34 442578 AK001643 Hs. 8395 hypothetical protein FU10781 3. 71 3. 42 448966 AW372914 Hs. 86149 phosphoinositol 3phosphate-binding prot 3. 68 3. 31 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 3. 68 4. 24 400750 Target Exon 3. 68 2. 74 447217 BE465754 Hs. 17778 neuropilin 2 3. 66 3. 60 459373 BE408266 Hs. 301406 hypothetical protein PP3501 3. 66 3. 48 419628 H67546 Hs. 49768 ESTs 3. 62 4. 13 406868 AA505445 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 3. 61 4. 40 421866 M24470 Hs. 1435 guanosine monophosphate reductase 3. 59 3. 53 421709 AA159394 Hs. 107056 CED-6 protein 3. 57 2. 63 438501 Z44110 Hs. 86149 phosphoinositol 3-phosphate-binding prot 3. 56 3. 54 408962 BE386436 Hs. 44317 SRY (sex determining region Y)-box 10 3. 55 2. 70 425139 AW630488 Hs. 25338 protease, serine, 23 3. 50 2. 80 428411 AW291464 Hs. 10338 ESTs 3. 49 2. 58 452744 A1267652 Hs. 246107 HomosapiensmRNA ; cDNADKFZp434E082 (fr 3. 48 4. 61 411305 BE241596 Hs. 69547 myelin basic protein 3. 48 3. 37 447343 AA256641 Hs. 236894 ESTs. Highly similar to S02392 alpha-2-m 3. 47 2. 68 429954 A1918130 Hs. 21374 ESTs 3. 47 2. 63 417621 AV654694 Hs. 82316 interferon-induced, hepati6s C-associat 3. 46 2. 34 435256 AF193766 Hs. 13872 cytokine-like protein C17 3. 46 2. 47 450534 A1570189 Hs. 25132 KIAA0470 gene product 3. 42 3. 65 421100 AW351839 Hs. 124660 HomosapienscDNA : FLJ21763 fis, clone C 3. 41 2. 63 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 3. 40 4. 02 442711 AF151073 Hs. 8645 hypothetical protein 3. 39 2. 95 453344 BE349075 Hs. 44571 ESTs 3. 38 2. 38 436700 A1693690 Hs. 301406 hypothetical protein PP3501 3. 36 4. 60 418007 M13509 Hs. 83169 matrix metalloproteinae 1 (inters66å 3. 36 2. 61 433867 AK000596 Hs. 3618 hippocalcin-like 1 3. 36 4. 26 408393 AW015318 Hs. 23165 ESTs 3. 36 2. 10 447484 AA464839 Hs. 292566 hypothetical protein FLJ14697 3. 36 2. 49 412828 AL133396 Hs. 74621 prion protein (p27-30) (Cfeutzfeid-Jakob 3. 35 2. 27

426158 NM001982 Hs. 199067 v-erb-b2 avian erythroblastic leukemia v 3. 35 2. 58 440325 Nom003812 Hs. 7164 a disintegdn and metalloproteinase doma 3. 34 2. 55 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 3. 34 5. 96 439963 AW247529 Hs. 6793 ptateiet-activating factor acetylhydrola 3. 34 2. 73 406663 U24683 immunoglobulin heavy constant mu 3. 31 5. 21 427540 R12014 Hs. 20976 ESTs 3. 30 3. 40 412141 Api183838 Hs. 48938 hypothe6cai protein FLJ21802 3. 29 2. 80 400282 NM005313 : Homo sapiens glucose regulated 3. 29 3. 46 419870 AW403911 Hs. 266175 phosphoprotein associated with GEMs 3. 28 5. 20 416539 Y07909 Hs. 79368 epithelial membrane protein 1 3. 28 2. 79 431518 AA743462 Hs. 165337 ESTs 3. 27 2. 51 402994 NM 002463 : Homo sapiens myxovirus (influ 3. 26 6. 38 419956 AL137939 Hs. 40096 cadherin 19, bpe 2 3. 26 4. 48 421379 Y15221 Hs. 103982 small inducible cytokine subfamily B (Cy 3. 26 3. 71 444371 BE540274 Hs. 239 forkhead box Mt 3. 25 3. 72 432874 W94322 Hs. 279651 melanoma inhibitory activity 3. 25 5. 33 417282 AA195203 RABSC, member RAS oncogene family 3. 24 3. 20 439569 AW602166 Hs. 222399 CEGP1 protein 3. 24 2. 32 422530 AW972300 Hs. 118110 bone marrow stromal cell antigen 2 3. 24 6. 20 403817 NM 015271 : Homo sapiens Wparfite mobf-3. 23 3. 70 407857 A1928445 Hs. 92254 synaptotagmin-like 2 3. 22 2. 49 426334 BE305081 Hs. 169358 hypothetical protein 3. 21 2. 46 453837 AL138387 Hs. 256126 baculoviral IAP repeat-containing 7 (liv 3. 19 5. 50 427283 AL119796 Hs. 174185 ectonucleo6de pyrophosphataselphosphodi 3. 18 2. 04 437379 AL359575 Hs. 23765 HomosapiensmRNA ; cDNADKFZpS47M123 (fr 3. 18 3. 73 424090 X99699 Hs. 139262 XIAP associated factor-1 3. 18 4. 44 410491 AA465131 Hs. 64001 Homo sapiens clone 25218 mRNA sequence 3. 18 3. 26 408418 AW963897 Hs. 44743 KIAA1435 protein 3. 16 2. 21 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 3. 16 4. 04 402829 C1002500 : gil6754254lref ; NP_034610. 1lhea 3. 15 4. 57 437862 AW978107 Hs. 5884 Homo sapiens mRNA ; cDNA DKFZp586C0224 (f 3. 15 3. 07 425935 Z98200 Hs. 163724 HSPC019 protein 3. 14 3. 08 417124 BE122762 Hs. 25338 ESTs 3. 14 2. 73 425071 NM 013989 Hs. 154424 deiodinase, iodothyronine, type 11 3. 11 2. 16 412490 AW803564 Hs. 288850 Homo sapiens cDNA : FLJ22528 fis, clone H 3. 10 2. 43 442271 AF000652 Hs. 8180 syndecan binding protein (syntenin) 3. 10 2. 83 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t 3. 10 1. 78 429083 Y09397 Hs. 227817 BCL2-related protein A1 3. 10 3. 17 437673 AW665665 Hs. 153034 ESTs 3. 10 3. 32 407813 AL120247 Hs. 40109 KIAA0872 protein 3. 10 3. 90 445745 AB007924 Hs. 13245 KIAA0455 gene product 3. 10 3. 35 451537 R56631 Hs. 26550 retinoid X receptor, gamma 3. 09 4. 45 408654 BE018882 Hs. 46721 UCC1 prdein 3. 08 3. 65 444484 AK002126 Hs. 11260 hypothetical protein FLJ11264 3. 08 2. 12 446019 Al362520 histonedeæeblae3 3. 08 2. 26 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 3. 08 5. 29 427871 AW992405 Hs. 59622 Homo sapiens, clone IMAGE : 3507281, mRNA, 3. 06 3. 36 403532 NM 024638 : Homo sapiens hypothetical prot 3. 06 3. 37 433160 AW207002 Hs. 134342 TASP for testis-specificadriamycin sens 3. 04 3. 17 446341 AL040763 Hs. 310735 ESTs, Moderately similar to ALU7 HUMAN A 3. 03 2. 98 426501 AW043782 Hs. 293616 ESTs 3. 03 2. 01 450325 A1935962 Hs. 91973 ESTs 3. 02 2. 19 418941 AA452970 Hs. 239527 E1B-55kDa associated prdein 5 3. 02 3. 29 431797 BE169641 Hs. 270134 hypothetical protein FLJ20280 3. 02 2. 54 442064 Api422867 Hs. 88594 ESTs 3. 00 1. 96 405451 dihydropyrimidinase-like 3 3. 00 2. 98 414915 NM 002462 Hs. 76391 myxovirus (influenza) resistance 1, homo 2. 99 6. 41 454117 BE410100 Hs. 40368 adaptor-related protein complex 1, sigma 2. 98 3. 25 452958 AA883929 Hs. 40527 ESTs 2. 98 4. 14 427647 W19744 Hs. 180059 HomosapienscDNAFW20653fis, cloneKA 2. 96 3. 30 409190 AU076536 Hs. 50984 sarcoma amplified sequence 2. 96 2. 47 428819 AL135623 Hs. 193914 KIAA0575geneproduct 2. 96 4. 16 428450 NM014791 Hs. 184339 KIAA0175 gene product 2. 96 2. 41 414219 W20010 Hs. 75823 ALL1-fused gene from chromosome 1q 2. 95 2. 79 411358 R47479 Hs. 94761 KIAA1691 protein 2. 95 4. 70 432467 T03667 Hs. 239388 Human DNA sequence from clone RP1-304314 2. 94 2. 65 400222 NM002082' : Homo sapiens G protein-couple 2. 94 2. 69 405785 NM025184' : Homo sapiens hypothetical pro 2. 94 2. 55 409760 AA302840 gb : EST10534 Adipose tissue, white I Homo 2. 94 2. 57 418113 AI272141 Hs. 83484 SRY (sex determining region Y)-box 4 2. 93 2. 52 409038 T97490 Hs. 50002 small inducible cytokine subfamily A (Cy 2. 93 2. 43 456760 AW961251 Hs. 127828 guanine nucleo6de binding protein (G pr 2. 92 3. 20 459710 A1701596 Hs. 121592 ESTs 2. 91 4. 45 411395 AA889673 Hs. 7542 KIAA1802 protein 2. 90 2. 72 427528 AU077143 Hs. 179565 minichromosome maintenance deficient (S. 2. 90 2. 27 406964 M21305 FGENES predicted novel secreted protein 2. 90 2. 03 428834 AW899713 Hs. 339315 ESTs 2. 89 3. 55 413190 AA151802 Hs. 40368 adaptor-related protein complex 1, sigma 2. 89 3. 87 438619 AB032773 TU12B1-TYprotein 2. 88 2. 37 442432 BE093589 Hs. 38178 hypothetical protein FU23468 2. 87 2. 00 428782 X12830 Hs. 193400 intedeukin 6 receptor 2. 86 2. 51 454027 R40192 Hs. 21527 HumanDNAsequencefromcloneGS1-11SM3 2. 86 3. 07 453107 NM_016113 Hs. 279746 vanilloid receptor-like protein 1 2. 86 5. 58

414737 A1160386 Hs. 125087 ESTs 2. 84 2. 79 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 2. 84 3. 80 447735 AA775268 Hs. 6127 Homo sapiens cDNA : FLJ23020 fis, clone L 2. 83 2. 11 416091 AF295370 Hs. 283082 defensin, beta 3 2. 83 3. 32 442445 AA082665 Hs. 209561 KIAA1715 protein 2. 81 2. 17 408208 BE018717 ESTs 2. 81 2. 43 430066 AB29659 Hs. 237825 signal recognition particle 72kD 2. 80 2. 25 424755 AB033094 Hs. 152925 KIAA1268 protein 2. 80 2. 74 422616 BE300330 Hs. 118725 seienophosphate synthetase 2 2. 79 2. 01 405506 Target Exon 2. 78 2. 65 411619 Al418609 Hs. 71040 hypothetical protein FLJ20425 2. 78 3. 10 400236 Eos Control 2. 78 2. 21 452698 NM 001295 Hs. 301921 chemokine (C-Cmo6f) receptor1 Z78 3. 15 446488 AB037782 Hs. 15119 KIAA1361 protein 2. 78 2. 80 439778 AL109729 Hs. 99364 putative transmembrane protein 2. 78 3. 78 420005 AW271106 Hs. 133294 ESTs 2. 78 2. 86 428642 NM_014899 Hs. 10432 KIAA0878 protein 2. 77 3. 07 453779 N35187 Hs. 43388 28kD interferon responsive protein 2. 76 4. 56 425289 AW139342 Hs. 155530 interferon, gamma-inducible protein 16 2. 76 1. 83 437723 Api672731 Hs. 13256 ESTs 2. 76 4. 23 416730 T99937 gb : ye72dO4. r1 Soares fetal liver spleen 2. 76 2. 98 426153 AF057169 Hs. 182771 vitelliform macular dystrophy (Best dise 2. 76 3. 21 444670 H58373 Hs. 332938 hypothetical protein MGC5370 2. 76 3. 97 421351 AU076667 Hs. 103755 receptor-interacting serine-threonineki 2. 74 3. 50 406673 M34996 Hs. 198253 major histocompatbility complex, class 2. 74 3. 24 427268 X78520 Hs. 174139 chloride channel 3 2. 74 2. 82 428403 Api393048 Hs. 326159 leucine rich repeat (in FLI I) interactin 2. 74 1. 95 409417 AA156247 Hs. 104879 serine (orcysteine) proteinase inhibito 2. 74 2. 99 419705 AW368634 Hs. 154331 ESTs 2. 74 2. 28 440457 BE387593 Hs. 21321 HomosapienscloneFLB9213PR02474mRNA, 2. 72 3. 60 413599 AJ006239 Hs. 75438 quinoiddihydropteridinereductase 2. 72 2. 43 447164 AF026941 Hs. 17518 vipirin ; similar to inflammatory respon 2. 72 4. 77 430594 AK000790 Hs. 246885 hypothetical protein FLJ20783 2. 72 3. 67 413278 BE563085 Hs. 833 interferon-s6mulatedprdein, 15kDa 2. 71 12. 06 424572 M19650 Hs. 179600 2, 3-cyclicnucleo6de3 phosphodieste 2. 70 2. 40 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 2. 70 3. 81 425996 W67330 hypothetical protein AL110115 2. 69 3. 85 430441 BE398091 desmoplakin (DPI, DPII) 2. 68 2. 55 442355 AA456539 Hs. 8262 lysosomal-associated membrane protein 2 2. 68 1. 67 421362 AK000050 Hs. 103853 hypothetical protein FU20043 2. 68 2. 94 437158 AW090198 KIAA1150 protein 2. 68 1. 89 412315 AW936678 gb : PM2-DT0023-080300-004-aO4DT0023Homo 2. 68 2. 80 432878 BE386490 Hs. 279663 Pirin 2. 68 2. 58 408822 AW500715 Hs. 57079 Homo sapiens cDNA FU13267 fis, clone OV 2. 68 2. 74 426759 Api590401 Hs. 21213 ESTs 2. 68 2. 35 405486 Target Exon 2. 67 2. 70 410326 Api368909 Hs. 47650 ESTs 2. 67 3. 33 434040 AW444613 Hs. 288809 hypothetical protein FLJ20159 2. 66 2. 54 437396 BE140396 Hs. 21621 hypothetical protein DKFZp7620076 2. 66 1. 91 412719 AW016610 Hs. 816 ESTs 2. 66 4. 21 451708 Api306536 Hs. 60975 ESTs 2. 66 5. 69 418299 AA279530 Hs. 83968 integnn, beta 2 (antigen CD18 (p95), iy 2. 66 2. 31 425017 AL119305 Hs. 26409 ESTs 2. 66 2. 73 400235 Nom005336 : Homo sapiens high density lipo 2. 66 2. 29 444809 BE207568 Hs. 208219 oculospanin 2. 64 2. 86 436291 BE568452 Hs. 344037 protein regulator of cytokinesis 1 2. 64 2. 33 406382 C16001275-: gil12698037ldbjlBA821837. 1l (2. 64 2. 48 432241 A1937060 Hs. 6298 KIAA1151 protein 2. 63 3. 16 417308 H60720 Hs. 81892 KIAA0101 gene product 2. 63 2. 10 429294 AA095971 Hs. 198793 Homo sapiens cDNA : FLJ22463 fis, clone H 2. 62 2. 43 453935 Api633770 Hs. 42572 ESTs 2. 62 1. 99 401454 NM014226' : Homo sapiens renal tumor an6 2. 62 3. 01 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 2. 62 5. 94 418478 U38945 Hs. 1174 cydin-dependentkinase inhibitor 2A (me 2. 61 3. 02 453256 A1565587 Hs. 32556 KIAA0379 protein 2. 60 2. 68 451622 AW139587 Hs. 30579 HomosapienscDNA : FLJ23070 fis, clone L 2. 60 2. 51 424006 AF054815 Hs. 137548 CD84 antigen (leukocyte antigen) 2. 60 2. 56 409354 N68188 Hs. 159472 Homo sapiens cDNA : FLJ22224 fis, clone H 2. 59 3. 00 425392 N39725 Hs. 15220 zinc finger protein 106 2. 58 3. 52 427286 AW732802 Hs. 2132 epidermal growth factor receptor pathway 2. 58 1. 86 418166 Al754416 Cdc42 effector protein 3 2. 58 2. 15 413794 AF234532 Hs. 61638 myosin X 2. 58 2. 54 445707 A1248720 Hs. 114390 ESTs 2. 58 1. 95 416640 BE262478 Hs. 79404 neuron-specific protein 2. 57 2. 46 427982 NM_016156 Hs. 181326 KIAA1073 protein 2. 56 1. 74 439453 BE264974 Hs. 6566 thyroid hormone receptor interactor 13 2. 56 2. 22 455839 BE145814 gb : MRO-HT0208-101299-202-aO4 HT0208 Homo 2. 55 2. 34 447737 AK000643 Hs. 19404 DKFZP564L0862 protein 2. 55 2. 31 423799 AW026300 Hs. 132906 19A24 protein 2. 54 2. 11 442762 AF035119 Hs. 8700 deleted in liver cancer 1 2. 54 2. 47 432886 BE159028 Hs. 279704 chromatin accessibility complex 1 2. 54 3. 99 440676 NM004987 Hs. 112378 LlMandsenescentcellan6gen-likedoma 2. 54 2. 96 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 2. 53 6. 98

422340 AW296219 Hs. 115325 RAB7. member RAS oncogene family-like 1 2. 53 3. 06 428844 AW972635 Hs. 301904 hypothetical protein FLJ12671 2. 53 3. 13 458997 AW937420 ESTs 2. 53 1. 63 419591 AF090900 Hs. 91393 Homo sapiens cDNA : FLJ21887 fis, clone H 2. 52 2. 30 414807 Art738616 Hs. 77348 hydroxyprostaglandin dehydrogenase 15- (N 2. 52 1. 80 429238 NM 002849 Hs. 198288 protein tyrosine phosphatase, receptor t 2. 52 3. 02 432882 NM 013257 Hs. 279696 serum/glucocorticoid regulated kinase-li 2. 52 3. 05 407260 L09095 gb : Homo sapiens mRNA fragment 2. 50 5. 00 431186 NM 012249 Hs. 250697 ras-like protein 2. 49 6. 16 417542 J04129 Hs. 82269 progestagen-associated endometrial prote 2. 49 4. 71 419556 U29615 Hs. 91093 chitinase 1 (chitotriosidase) 2. 48 5. 77 408209 Nom_004454 Hs. 43697 ets variant gene 5 (ets-related molecule 2. 48 3. 77 405885 Target Exon 2. 46 3. 11 406837 R70292 Hs. 156110 immunoglobulin kappa constant 2. 44 3. 10 412609 Z48804 Hs. 74124 ocular albinism t (Nenleship-Falls) 2. 44 4. 90 421633 AF121860 Hs. 106260 sorting nexin 10 2. 44 4. 31 415929 AA724373 Hs. 49344 hypothetical protein FU11006 2. 42 3. 19 413171 AA318325 Hs. 75219 tyrosinase-related protein 1 2. 37 3. 57 406621 X57809 Hs. 8997 immunoglobulin lambda locus 2. 36 5. 87 414142 AW368397 Hs. 334485 hemicentin (fibulin6) 2. 36 3. 04 410700 AA352335 Hs. 65641 hypothetical protein FU20073 2. 36 3. 66 414283 AW960011 Hs. 154993 ESTs 2. 34 4. 95 453931 AL121278 Hs. 25144 ESTs 2. 34 4. 18 422515 AW500470 Hs. 117950 mulGfunctional polypeptide similar to S 2. 32 3. 45 435292 N20514 Hs. 172965 ESTs 2. 32 4. 94 412926 Api879076 Hs. 75061 macrophage myristoylated alanine-rich C 2. 31 3. 78 440197 AW340708 Hs. 317714 pallid (mouse) homolog, pallidin 2. 30 3. 95 425262 D87119 Hs. 155418 GS3955 protein 2. 29 5. 08 439979 AW600291 Hs. 6823 hypothetical protein Fla 10430 2. 28 4. 05 403969 ENSP00000034663 : Zinc finger protein 131 2. 28 3. 64 421686 AB011156 Hs. 106794 KIAA0584 protein 2. 26 3. 31 432800 BE391046 Hs. 278962 AIM-1 protein 2. 24 4. 08 406782 AA430373 gb : zw20f11. s1 Soares ovary tumor NbHOT H 2. 24 3. 47 415539 A1733881 Hs. 72472 BMP-R1B 2. 22 3. 66 447523 BE613328 Hs. 21938 hypothetical protein FLJ12492 2. 20 3. 43 433180 AB038651 Hs. 31854 K562 cell-derived leucine-zipper-like pr 2. 20 3. 52 415825 Y18024 Hs. 78877 inositol 1 45-trisphosphate3-kinae8 2. 19 3. 76 407241 M34516 gb : Human omega light chain protein 14. 1 2. 18 3. 17 422243 AW803733 Hs. 23585 hypothetical protein MGC12250 2. 18 3. 28 417324 AW265494 ESTs 2. 16 5. 85 412819 T25829 Hs. 24048 FK506 binding protein precursor 2. 14 3. 49 432342 AL036128 Hs. 274404 plasminogen activator, tissue 2. 13 4. 39 427923 AW274357 Hs. 301406 hypothetical protein PP3501 2. 13 5. 48 417437 U52682 Hs. 82132 interferon regulatory factor 4 2. 13 3. 08 425535 AB007937 Hs. 158287 KIAA0468 gene product 2. 13 8. 66 429638 A1916662 Hs. 211577 kinecbn 1 (kinesin receptor) 2. 12 3. 01 409154 U72882 Hs. 50842 interferon-induced protein 35 2. 12 4. 66 429951 AL040521 Hs. 15220 zinc finger protein 106 2. 12 3. 71 418918 X07871 Hs. 89476 CD2 an6gen (p50), sheep red blood cell 2. 11 4. 27 419200 AW966405 EST 2. 11 3. 58 416448 L13210 Hs. 79339 lecGn, galactoside-binding, soluble, 3 2. 10 5. 34 425069 AA687465 Hs. 298184 potassium voltage-gated channel, shaker-2. 07 7. 86 445133 AW157646 Hs. 198689 ESTs 2. 06 3. 68 411492 T46848 Hs. 70337 immunoglobulin superfamily, member 4 2. 04 3. 36 408015 AW136771 Hs. 244349 epidermal differentiation complex protei 2. 03 3. 41 424412 H15512 Hs. 10043 hypothetical protein FLJ13074 Z03 3. 82 431657 A1345227 Hs. 105448 ESTs Weakly similar to B34087 hypotheb 2. 02 3. 03 427536 BE277141 Hs. 115803 gb : 601178666F1 NlH_MGC_20Homosapiensc 2. 02 3. 09 400533 ENSP00000209376 : PRED65 protein (Fragmen 2. 00 3. 29 432680 T47364 Hs. 278613 interferon, alpha-inducible protein 27 1. 99 3. 07 410129 BE244074 Hs. 58831 regulator of Fas-induced apoptosis 1. 97 4. 52 417312 AW888411 Hs. 250811 leukemia. associated phosphoprotein p18 (1. 97 3. 26 423952 AW877787 Hs. 136102 KIAA0853 protein 1. 94 3. 79 455705 AW161061 ESTs Weakly similar to zinc finger prot 1. 93 3. 16 419723 AL120193 Hs. 339810 longevity assurance (LAG1, S. cerevisiae 1. 93 3. 11 438866 U44385 Hs. 325495 tissue inhibitor of metalloproteinase 2 1. 93 3. 47 448410 AK000227 Hs. 21126 hypothefical protein FU20220 1. 92 3. 00 400292 AA250737 Hs. 72472 BMP-R1B 1. 92 4. 07 436797 AA731491 Hs. 334477 hypothetical protein MGC14879 1. 90 3. 04 406851 AA609784 major histocompatibility complex, class 1. 90 6. 53 428437 AV656017 Hs. 184325 CGI-76 protein 1. 89 3. 39 431836 AF178532 Hs. 271411 beta-site APP-cleaving enzyme 2 1. 89 4. 04 424687 J05070 Hs. 151738 matrix metalloproteinase 9 (gelatinase B 1. 87 3. 64 426322 J05068 Hs. 2012 transcobalamin I (vitamin 812 binding pr 1. 85 4. 21 425221 AV649864 Hs. 155188 TATAboxbindingprotein (T8Ppassociate 1. 85 3. 13 420162 BE378432 Hs. 95577 cyclin-dependent kinase 4 1. 85 3. 04 443530 BE563088 Hs. 9552 binder of Art Two 1. 85 3. 20 433671 AW138797 Hs. 132906 19A24 protein 1. 84 3. 39 424415 NM 001975 Hs. 146580 enolase 2. (gamma. neuronal) 1. 82 3. 22 400991 Target Exon 1. 82 4. 11 418677 S83308 Hs. 87224 SRY (sex determining region Y)-box 5 1. 82 3. 43 424441 X14850 Hs. 147097 H2A histone family, member X 1. 81 3. 12 424825 AF207069 Hs. 153357 procollagen-lysine, 2-oxoglutarate 5-dio 1. 79 5. 31

425818 AB021225 Hs. 159581 matrix metalloproteinase 17 (membrane-in 1. 79 3. 40 416426 AA180256 Hs. 210473 Homo sapiens cDNA FW14872 fis, clone PL 1. 78 3. 38 414945 BE076358 Hs. 77667 lymphocyte antigen 6 complex, locus E 1. 77 3. 69 440942 AW246547 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 1. 77 3. 12 401591 Target Exon 1. 75 4. 30 425923 NM 005026 Hs. 162808 phosphoinositide-3-kinase, catalytic, de 1. 75 3. 68 412844 Af828045 Hs. 18016 HomosapiensmRNA ; cDfiADKFZpS86H03242 1. 74 3. 53 417237 H86385 Hs. 81737 pamitoyl-protein thioesterae 2 1. 73 3. 06 419849 BE041436 Hs. 93379 eukaryotic translation initiation factor 1. 72 4. 38 454429 BE273437 Hs. 301406 hypothetical protein PP3501 1. 72 4. 38 440672 AF083811 Hs. 7345 MAD1 (mitotic arrest deficient, yeast, h 1. 72 3. 61 408204 AA454501 Hs. 43666 protein tyrosine phosphatase type IVA, m 1. 72 3. 06 430148 BE387620 Hs. 234489 lactate dehydrogenase B 1. 71 4. 38 426502 Y07759 Hs. 170157 myosin VA (heavy polypeptide 12, myoxin) 1. 70 3. 13 413317 U53225 Hs. 75283 sorting nexin 1 1. 70 3. 08 417333 AL157545 Hs. 173179 bromodomain and PHD finger containing, 3 1. 68 3. 15 407223 H96850 gb : yw03b12. s1 Scares melanocyte 2NbHM Ho 1. 68 4. 19 413566 AW604451 Hs. 285814 sprouty (Drosophila) homolog 4 1. 67 5. 74 404067 Target Exon 1. 67 4. 73 447630 Af660149 Hs. 44865 lymphoid enhancer-binding factor 1 1. 66 3. 22 443337 Y07604 Hs. 9235 non-metastatic cells 4, protein expresse 1. 65 3. 17 427747 AW411425 Hs. 180655 serine/theoninekinase12 1. 64 3. 35 437912 BE278594 Hs. 5912 F-box only protein 7 1. 64 3. 24 404140 NM006510 : Homosapiensretfingerprotei 1. 64 3. 10 414214 D49958 Hs. 75819 glycoprotein M6A 1. 64 3. 45 427239 BE270447 ubiquitin carrier protein 1. 62 3. 58 427289 A1097346 phosphoserine aminotransferase 1. 62 5. 89 452923 BE276018 Hs. 288940 five-span transmembrane protein M83 1. 62 3. 23 426020 AL110195 Hs. 166017 microphthatmia-associated transcription 1. 62 4. 00 439627 BE621702 Hs. 29076 hypothetical protein FU21841 1. 61 5. 00 451489 NM005503 Hs. 26468 amyloid beta (A4) precursor protein-bind 1. 60 3. 06 414699 Api815523 Hs. 76930 synuclein, alpha (non A4 component of am 1. 58 3. 34 411825 AK000334 hypothefical protein FW20327 1. 56 3. 18 438552 AJ245820 Hs. 6314 type I transmembrane receptor (seizure-r 1. 56 3. 23 428081 AA421048 Hs. 95011 syntrophin, beta 1 (dystrophin-asociate 1. 55 3. 10 401914 Target Exon 1. 54 3. 33 424902 NM 003866 Hs. 153687 inosilol polyphosphateXphosphatme, w 1. 54 3. 15 441648 H05734 Hs. 30559 ESTs 1. 52 3. 36 439769 AA448828 Hs. 30596 Homo sapiens mRNA full length insert cDN 1. 52 3. 17 437696 Z83844 Hs. 5790 hypothetical protein dJ37E16. 5 1. 52 4. 93 413019 BE281604 Hs. 75140 low density lipoprotein-related protein-1. 52 3. 01 419741 NM_007019 Hs. 93002 ubiquitin carrier protein E2-C 1. 52 3. 83 422596 AF063611 Hs. 118633 Z-S-oligùadenylatesynthetase-like 1. 50 3. 04 421851 R18686 Hs. 108896 lambdacrystallin 1. 47 3. 10 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 1. 44 3. 07 427378 BE515037 Hs. 177556 melanoma antigen, family D, 1 1. 44 3. 00 412641 M16660 Hs. 74335 heat shock 90kD protein 1, beta 1. 42 3. 66 448143 AF039704 Hs. 20478 ceroid-lipofuscinosis, neuronal 2, late 1. 42 4. 16 413291 NM006278 Hs. 75268 sialyltransferase 4C (beta-galactosidase 1. 41 3. 30 435968 AW161481 Hs. 1 11577 integral membrane protein 3 1. 41 3. 30 422486 BE514492 Hs. 117487 genenearHDon4p16. 3withhomologyto 1. 40 3. 01 443759 BE390832 Hs. 134729 FXYD domain-containing ion transport reg 1. 39 3. 82 444441 AW613841 Hs. 301394 hypothetical protein MGC3101 1. 39 3. 43 430205 AB025904 Hs. 235168 carbonic anhydrase XIV 1. 36 3. 32 406827 AA971409 gb : op92cO4. s1 CGAPLu5 Homo sapiens 1. 35 3. 03 406906 Z25424 gb : H. sapiens protein-serine/threonine ki 1. 34 6. 25 426890 AA393167 Hs. 41294 ESTs 1. 34 3. 66 433320 D60647 Hs. 250879 ESTs, Highly similar to CTXN RAT CORTEXI 1. 34 3. 18 450358 AB010098 Hs. 24907 coronin, acGn-binding protein, 2B 1. 33 3. 19 421612 AF161254 Hs. 106196 8D6 antigen 1. 33 3. 03 438915 AA280174 Hs. 285681 Williams-Beuren syndrome chromosome regi 1. 32 3. 68 428342 A1739168 Homo sapiens CDNA FU 13458 fis, clone PL 1. 32 3. 10 449444 AW818436 solutecarnerfamily16 (monocaboxylic 1. 30 3. 30 404700 Target Exon 1. 30 3. 14 403043 Target Exon 1. 30 4. 22 409858 NM 006586 Hs. 56828 trinudeotide repeat containing 5 1. 29 3. 09 424679 AL117477 Hs. 119960 DKFZP727G051 protein 1. 27 3. 13 406908 Z25437 gb : H. sapiens protein-tyrosine kinase gen 1. 27 3. 66 432665 AW603880 ATPase, H transporting. lysosomal (vacuo 1. 26 3. 09 423130 AW897586 Hs. 21213 ESTs 1. 24 3. 34 453220 AB033089 Hs. 32452 HomosapiensmRNAforKIM1263protein, 1. 24 3. 15 442680 BE270707 Hs. 8583 similartoAPOBEC1 1. 22 3. 94 422319 AW403342 Hs. 115232 splicing factor 3a, subunit 2, 66kD 1. 21 3. 36 402408 NM030920' : Homo sapiens hypothetical pro 1. 04 3. 37 424905 NM_002497 Hs. 153704 NlMA (neverinmitosisgeneaFrelatedk 1. 00 3. 02 TABLE S 1B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession

430540 713-2 BC017171 BC012195 NM007126 AF100752 AL137377 Z70768 BM474865 BG754806AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 B1759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 AI 770171 BF196861 BE856897 AA463876 A1375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 Ai365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 A1651927 AW151143 B1198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG BF996406 BF988930 BM475542 AW246215 BE501897 8E903610 BE561530 BE560537 BE903782 BE732947 B1227204 BG761305 BE262642 BE391848 BE382475 BG008258 B1547991 B1459099 BE391391 BE259420 BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 A1359493 BM018598 A1689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 Bai041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 Bai091658 N72512 W58732 W85690 BG958989 A) 205206 H19721 W17051 W77958 B1262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 A1027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 Aï243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU 185751 AW971465 AA489681 AW971893 AW612086 BE077936 B1860809 BE002760 BG746251 BE962912 Bu454584 AL134894 BF104082 H80591 437179 12239 1 AK055109 BC019085 AA187684 BG656226 BM023227 AI932311 AW264381 AA398371 BM021483 AI432433 AI375777 AIt129580 AW262782 AA134107 BM023515 AA977504 AI859222 AI348454 R69725 AA975268 BM021207 AL080074 AA129218 AW207842 N90581 AA771919 A1092259 A1028416 A1074114 BG656536 BE501677 AW193419 AA917040 W90430 AI342984 AI378957 AL036486 AW020068 B1491093 BF476021 R41226 R69631 F04125 C02343AA115589 R56480AM0988 R54266 R31422 412652 18858-2 A1801777 BE677762 AW008210 AW009441 BE350994 BE207949 A1091475 AI802774 AI827533 A1075363 AI659979 AA687855 AN78125 A) 090285 AA670058 AA602411 AA683472 A1436058 AA612826 A1038932 BG057726 A1167355 BF449023 A1289476 AW074381 OF972912 A1991780 AA889119 AI537472 Z39730 AI868953 AI192337 BE812978 BE812939 AA115248 H99006 AI915784 F08973 T16748 D20468 AA609899 BF081234 AA115336 BE812876 BE812972 BE812982 BE813006 BE813019 R43883 BE812981 430015 713-2 BC017171 BC012195 Nom007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 B1759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 A1770171 BF 196861 BE856897 AA463876 A ! 375927 AA648810AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 Au 365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 81198825 BG819083 BM458764 Bye903567 BE732715BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 M475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 B1227204 BG761305 BE262642 BE391848 BE382475 BG008258 B1547991 B1459099 BE391391 BE259420 BE298109 AW245422 A1423847 A1914618 H80534 BE301004 AL531791 Ait BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953 BG340524 W52648 AAl 13434 BE785431 B1041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 Bu091658 N72512 W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 8G180977 BE349455 AA812018 AA740241 A1027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 Api243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 Ai251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 B1860B09 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80. 591 420218 191547-1 AW958037 R42557 Ai337047 AA948360 Api638005 AA459950 AI624915 A1638047 AI467856 AI521826 AA860305 Ai932315 AW003092 AW271756 AW779380 AA609879 AI634791 AI493770 AI565211 Z41145 Ai627952 AA303734 BE349457 AW196765 AA256527 BE089727 410600 497855-1 BF347859 AW499616 Axai 91322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 AI335824 AW408712 BM149172 400282 7778 2 BC014433 Z49835 D16234 U42068 D83485 NM 005313 AL535156 AL533202 AL533596 AL531770 AL542767 AL551050 AL548510 AL542531 AL548618 BE799237 AL547374 AL560312 AL543505 AL540727 AL541255 BG765697 AUt 26498 81829574 BG576125 AL519304 AL548821 AL542983 B1596431 B1829284 AL045490 BE407984 B1668702 B1713725 BE547233 BM312673 BG822625 AW239512 BM312685 BE296719 BM312059 B171261 8 BM309832 B1712859 BE513604 BM310042 81712817 BG470156 AA305870 AW408391 BE298661 BG826781 BF726062 BM315135 BG472541 BF724689 AA353713 BF477104 81838605 BG1 70854 BE612762 BF917301 BF332271 Bai049186 BE715514 AW392181 BE768470 Ai912855 AW991405 BG739837 AA287804 AW801855 AL568814 AW384099 AW384058 AW754178 Arm1019 R33917 BE814037 AI557164 417282 2142 2 AK025474 U11293 AF141304 BM424202 AL539879 AL554793 AL543707 AL549509 Bai753328 BG756797 B1856494 BE901116 AL556989 AU133347 Bzw AW949559 BM012604 BG773980 OG661309 61260149 BF436764 BG983060 BF822225 81059728 BF917866 BF917609 BF914374 D31003 AA234218 AJ420466 BM083921 BE856788 BE669957 BF430992 AW614978 AW205958 BF110763 BF222758 AA195232 AI341353 AI698676 A1093230 All 23522 A1656594 A1208758 AA975916 A1089224 AI264922 AA256604 AA659637 BE218707 AA195203 AW999239 AW139706 N31717 AW205941 R95955 N39147 BM015411 AL576975 BF689524 AL563130 B1858155 AA417889 AL513995 AL568815 AU160693 AA836028 H84388 AL517078 AL546480 AL530507 AL561042 AA02"35 W47314 A1680513 AA456116 BF836679 AW975173 H24039 AW105059 BE548113 AW370257 BM01 1139 AW675130 BE276045 BF933396 AL517903 AA886367 B1030596 BG477193 BF973867 446019 658727 1 AI362520 D25917 AI670784 AI742347 AW269789 AI270700 AW610541 AW793036 AW793035 AW610540 AW362220 AW362166 AW362214 AW362225 AW362228 AL119827 400222 9287 3 NM002082 L16862 BG828886 BE795217 BE904064 BE294526 BE297283 BE394617 BE935127 BE935106 F12351 BG823182 H16710 409760 865166J AA302840T93016T92950AU184997AA077551 438619 35124_1 NM 016575 AB032773 AI765521 BF593742 AI497757 AI761233 AW467938 BF000670 A1819496 N24761 AL043306 BF476138 BF593836 AA132787 A1147248 A1086795 AA151317 T95298 AW083548 AA058371 N27951 AI769860 AI784548 AW205506 AI800679 A1041733 AI459902 BE327641 AI865829 AI254736 AI302433 AI 744176 AI241825 AA027842 AL524933 AL524932 BF947764 BF340737 BF948700 BG996395 N53455 N21027 Ale 27616 N35901 AA682443 AA678249 AA719371 AA132582 T15981 H99958 N40717 AW959402 Ai267251 BF909329 Au42035 T95379 H29420 R59632 H17318 H 17331 H29327 R40829 R43395 R59573 AI749561 R56599 H16755 AI694500 AA027907 408208 642734-1 B1757837 AW439843 AW172765 BE018717 BE464329 BE302285 H96902 BF477981 BE674508 BE670755 H95980T15387 400236 231 3 M80359 NM 002376 AU132239 AU120606 AU124963 A1065116 BE900808 BF968374 AI806648 BG774205 AW250728 BE265845 AA290719 AUt 25196 BG428863 AA333580 AA604551 W73300 AI932646 AA082201 AA627618 BF038887 BF337051 81021159 AW057581 AI983156 AI268004 T71931 T90093 AW194009 H93969 A1742843 AI935080 BE041751 H93970 AW797399 W05032 T87824 T82912 AW129639 AI221821 AI911810 AA703093 AA160135 AW779124 AA102559 AA969546 D29560 Bai915937 AA707716 Bai085679 AA700887 AA081085 416730 1988296-1 H80564 T99937 T70802 425996 138046_1 BM006551 AA367152 AW953705 AI631833 AW237429 AW027804 AA729038 BE503409 Ai521935 BF739953 AA702982 AA557633 AA780065 AI218139 AW194264 D20120 A1082715 AI969980 BE857686 BE326711 AW953706 AI393749 AI383821 W67199 AI431759 AI796526 AI521794 AI796380 AW1117545 AI749657 AI537634 N50122 430441 14386 BG108218 BE560548 AW380115 BE269629 AI911518 AW380113 AA902964 AA455001 AI276529 AI685597 AA970496 D61084 AW380068 AW380080 R00283 C15236 AW327776 D80759 437158 59575-1 AL050068 AA160485 AW173544 AW296506 AW439860 A1521563 A1702529 A1393606 AW1 38323 AA570109 H19504 BM021968 BF063327 BF593552 AA630766 AI597717 AI807128 AA523012 Ai356250 AW451857 AA974203 AI762577 BF512552 AW007307 BE675286 AW450602 AA962057 AW516069 A1582546 SF221924 BF222543 AI801 BO8 AW468599 AW000736 Api866625 AW235356 BM021837 AA911956 Ai680606 W86516 T03370 AW611634 H41653 Ai468349 H19588 AW090198 AW043993 R39847 412315 1163860-1 AW936678 AW936821 AW936683 AW936822 AW936781 AW936817 AW936811 AW936653 AW936823 AW936685 AW936815 AW936637 AW936812 AW936730 AW936762 AW936682 AW936732 400235 3084_1 BCOOt 179 NM_005336 M64098 BC014305 81827845 BI9918183 AU124191 AU125604 AU140930 AL043307 BG763670 BG824279 AU125959 B1518466 BE271867 BM264138 BE314823 BM090633 BE273657 BG419830 BM048338 AU134368 BE163486 BE163483 BG421980 BG768130 AW500482 Ai910107 AW868323 BF083170 AW450290 BM466817 BG255224 BE394282 AU140278 BE887464 AL042675 BI195986 BE883385 BE544751 BE270148 BMOt11334 A1093482 AA029803 AI610705 BE386809 F06628 AW408605 BF814085 BC007961 BM451548 BG768053 BM452948 AU140330 BG489566 B1870474 GM014013 AU131264 BG679824 B1225752 B1457400 SE410173 BM044254 BG763690 BE251495 BG179862 BE513489

BM005937 A1064815 BF569858 BI712614 BG655891 BG424940 BE 175180 BM313i60 BG471936 BM091l24 BF885884 BF870522 BE004490 BE712976 BE712862 AA401033 BF569477 BE712936 BF353839 BE713042 AA316561 BE712974 BE712977 BE712938 BE712937 BE712867 BE713043 BE713023 N42463 BE712901 BE713041 BE712904 BE712895 BE713012 BE713049 BE713025 BE712998 BE712988 BE712987 BE712986 BE712984 BE712982 BE712975 BE712970 BE712953 BE712929 BE712922 BE712875 BE712866 BE712861 BE712860 BE712854 BE712853 BE712902 BE712897 BE712912 BG984910 BE712903 BE764759 BE715723 BE715745 BE712915 AA441839 BE713040 BE715755 BF872528 BF060840 BG395104 BG744878 AU124081 AI889823 AI801072 AI633102 AI678670 AI493608 AW194294 AI354559 AI686736 AW 152477 AI419496 A1720319 A1866190 AA047013 AA039625 BE049622 AA369065 AA025686 A1570198 AA706304 AW439251 H64553 AW168006 A) 983753 AW081999 AW082909 AI951490 BF886341 AW591246 AI190143 AI151074 AI499541 A1050934 AA402167 AA382049 T 16207 T03299 AI932691 AW571663 BG479797 BE408436 B1460153 BG386046 BE616601 AW151629 BG236164 BF852743 BF852046 T57801 W37981 AA482668 H43740 W58142 W25087 BM459852 AU125403 BG767992 BE258516 A ! 114509BE394494 BE386905 AA450315 BG750593 AA557855 BG766487 BG766998 BF948864 BE279327 BE870900 AA577098 BF365851 AA745058 N29867 A1625038 AA641801 AA846174 H26395 AA025568 BF690282 R67845 R72666 H39554 T78959 W01317 H45860 W80837 N53985 BG757202 BE838055 BE072895 BE072668 BE867012 BM042833AA083591 BG745462 AW374086 BG831326 BE715757 BG767243 BG763272 AA113402 A1024044 BF818501 BE081938 BF353818 AA746336 BM019086 BE712894 H16977 H45012 R10793 BE708619 BF570432 AA593938 AA064637 T28082 AA852845 T78907 AA346590 F00017 BE966368 N58726 AA732431 T54379 W80749 BF238314 BE279768 AA325106 T19241 BE409939 BF852119 W23803 T54011 AW392638 B ! 465185 AW516784 AA211335 B1159846 AA064680 N80615 W49676 BF851406 R88120 AA434028 H44546 T61029 N44804 AA114948 H26960 B1261965 AA582599 BG469385 BF818172 BF923672 81024270 AW362633 BE883122 BM47W79 BE935760 AW856056 AW856103 BE828607 AW381799 AL121058 BE828618 BE769545 AA102142 BG74997sBl77o417 Bls62s44Al11o687 AF063562 BE740347 BE874864 A 305113 BE513675 BE091369 BI046660 BE091453 BI046548 Al673786 BF868704 A1025179 BF356840 BF886357 BF886313 BG951884 AI347880 AW627563 BF932536 AW820377 BF739372 BF831620 8E068264 BE613627 AA641745 W01130 H28252 418166 18858_1 AK055915 8E867252 AI523348 AA765350 BF446858143675 R19529 AL133837 BG389444 AW382942 BE702956 AA081961 BE835247 BE835308 BE835295 AA376302 BE645790 AA375690 AA376592 AW954423 N85732 AA249770 A1754416 AA213816 BF592044 AA811729 AW514842 A1633486 Al096810 AW183016 Al635738 N27524 BE645916 At247842 AW991230 Al754277 H16814 AI766892 BF108422 Api800361 T95129 F11313 R97946 R93989 AA375242 BF109388 A1860939 A1680060 AW953899 BF971486 A1972337 AW953B41 AA372437 A1216746 Hl 1384 R38484 AA249043 AA249732 455839 1518842 1 BE145823 BE145830 BE145884 BE145814 BE145905 BE145833 BE145834 BE145883 BE145889 458997 11847 4 BM453041 AA760783BE218582AI340046AW166131 BF515854AI630296AA461307AI090881 AW023059AA155797AA115486AL597396 AW889004 AW937420 AA137082 AA013374 BG619478 BG401839 406782 0 0 AA430373 AA968711 417324 292720_1 BG775668 BG680336 AW991605 AA455904 AW265494 AW265432 BF911380 AA456370 BF911379 AA195677 BF914311 BF913866 BG775059 BG951874 Al572169 419200 9531_t BF036043 AW190446 BG194731 AW662036 AI445021 BE937550 AW818972 AW393132 AA834685 BFi 12058 AV721682 H16423 AI270167 AI857345 AA937302 AW818444 BE929780 BG498678 BFI 55010 61598271 B1599811 BE161728 AW578737 AW753711 AW379707 AW381918 BG506608 AW028637 AW994240 BF887392 BF790073 AW381624 AV727105 8F439618 AA443174 A1018009 N42850 AW53242 AI417258 AA463483 AI676131 A1167170 AA836627 AA443828 AW592922 AA235129 AA730278 AW439062 AW474332 B1043239 AW474342 BG708553 AW362423 BF090028 BE827256 R16550 R39478 R39479 R94368 BGS40916 BM314745 AA251087 D54231 D55274 BF085805 D31589 AW966405 AW994425 D81879 BE093545 AW901107M383529 Bl021552 RS6420 N39976 AA573281 H82595 AA234955 BE093539 AW367006 BF358697 BF366318 AA663856 BE702099 BF035969 A) 267384 A ! 267232 BE348320 AA621574 AA861212 BF083343 BF083341 AV745131 D53074 AW954476 AW954472 AA376836 AV724531 D53063 C14928 AA093287 AA062638 BG483558 BE940050 AA765954 T70171 BE938775 BE940057 D53502 AW373300 A1118798 BM128728 AA193411 AW444709 AW952455 A1887612 BF431948 B1496876 A1264159 BM1 28481 A1624657 A1689301 A1969467 AA861685 AA251595 AA625761 AA872090 A1826790 AA328366 BE827416 R75951 D56918 R68122 BE827384 AL118797 A1184164 AA164411 81495332 BE858113 Api863860 H00660 T69849 AW780389 C14667 BE934995 Bol018652 R92801 AA164410 H00752 AW373305 AW373299 AW373302 455705 77478 2 BF971018 BE513812 AA133359 AW581719 BF434402 AL600619 BG699731 B1551395 AW027136 AW055130 BF939512 A1076048 H18584 AW161061 AA864334 Al816101 BE049456 AW044012 AA954079 Al274682 Al370526 AW131990 AA853195 AA853191 BG118295 AA761620 BG705371 BF355591 BF336596 AA360497 H28072 BG198352 AW364709 H40926 H44214 AA836538 Bol059563 406851 0 0 AA609784 R97304 427239 20459_2 AL532360 BE794750M582SO6 A1015067 AW271034 BG271636 AW075177 AW071374 Al345565 Al307208 BE138953 BE049086 Api334881 AW075006 AW075181 AA464019 AW302733 AW075100AW073433 Al802854 AB34909A1802853 Al345036 Al348921 Al340734 Al307478 Al251289 AW302327 AW072520 A1312145 AW073656 AW072513 AW071289 A1307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 Al252926 Al252160 Al251662 Al251262 Al610913 Al270787 Al270156 Al252075 AW073469 AW072901 AW072496 AW071420 Al305762 Al254764 AI802837 AI251264 AW073049 AW071311 At340643 BE138965 BE138502 AW073456 AI334733 A1054335 BE139260 A1054302 A1054060 A1054057 Al053722 Al289711 BE139228 AW470478 AW271039 AW302085 BE041872 Al254494 Al271496 Al252427 BF718773 BF718645 AW074866 BE857822 427289 1820_2 BC007350 BG766159 BG769338 BG761999 BG744385 BG770572 AW370610 AW370581 AA978353 AW327973 AW402425 A1889380AA868504 AW612968 AA630644 Api751211 N26980 AI394506 AA747849 BF154926 BF477185 AA649647 R39135 Api750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW37D651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 81261497 BIOI 8403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 Bl018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340033 Z20199 411825 7891 1 AK000695 AK000489 BC001688 BG235988 AW006329 AI887644 A1207230 AI148213 AI304333 Ai634653 AW662636 A1281247 AA946921 AA424487 BE272330 AI830588 AA159183 AA977141 BG231801 AA631793 AA975194 BF817537 AA477798 Bol906631 AW083424 AA625199 NM017767 AK000334 BF984048 AW815634 AL573992M430612 M928390 M4b4447 AW340827 AA424290 Al927759 BG951502 AW881353 B ! 765535 406827 0 0 AA971409 428342 6712_1 AK056315 Al015524 M724079 Bl713519AI377728 AW293582AI928140AI092404 Al035630M731340 BM469629 AW968804 AA425658 AA769094 BF446026 AW118719 Al332765AW500688 AW576556 Api859571 AW499664 AW614573 AW629495 AW505314 W74704 M356361 A1923640 AW070509 A1521500 AL042095 AA609309 AA761319 AI381489 H45700 AA761333 AW265424 AA909524 AA635311 AA649040 AI392620 Z40708 AI985564 AW263513 AA913892 AI693486 AW263502 AI806164 AW291137 BI061872 BI059498 AAi 34476 AW084888 AA036967 AW370823 T55263 Bl002756 MU9664 BF827261 W74741 BF963166 449444 2735_1 U59185 NM 004696 AV734324 AI245349 AA369517 H88760 D79128 AA970406 H01059 H88761 H03446 BG620383 AU135008 AU136895 AU158158 AU155762 R73608 R65751 R23756 N74630AW078687 BE439761 BE786351 R68994 BE785867 AW297502AW297553 BG431545 AW814843 BF382644 BG429539 BE929862 BF811258 432665 27095_3 BG165971 BE143233 AL577712 AI400326 AA769318 AA427866 AW088714 AI150755 AI924$74 AI186243 AA804195 AA768972 AW574769 AW341643 AW204520 AA235326 A1005076 BE826687 AW004816 AW007235 BE826639 BE826634 BF222941 BE826631 BE826643 AA292639 AW514133 AI690331 AI673409 AA627727 AI923685 AA931499 AI249783 AI810663 AA548622 AA702095 AA832395 B1259508 AA262993 AW075840 AA810885 TABLE 51C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (Gt) numbers. Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 402075 8117407 Plus 121907-122035, 122804-122921, 124019-12416

400860 9757499 Minus 151830-152104, 152649-152744 402609 9926446 Minus 113464-113633, 114264-114654 400750 8119067 Plus 198991-199168, 199316-199548 402994 2996643 Minus 4727-4969 403817 8962065 Plus 110297-111052 402829 8918414 Plus 101532-101852, 102006-102263 403532 8076842 Minus 81750-81901 405451 7622517 Minus 145949-146227 405785 9581533 Minus 98702-98925 405506 6466489 Plus 80014-80401, 80593-81125 405486 6651379 Plus 179441-179598 406382 9256148 Plus 122336-122851 401454 9186923 Minus 114659-114832 405885 7677703 Minus 42574-42998 403969 8569909 Plus 312373t375, 32405-32506 400533 6981826 Minus 277132-277595 400991 8096825 Plus 159197-159320 401591 9966977 Minus 55410-55835 404067 3282162 Plus 1415-2071 404140 9843520 Plus 37761-38147 401914 9369520 Plus 62537-62945, 63155-63308 404700 9800123 Minus 159621-160203 403043 7768753 Minus 314423-316252 402408 9796239 Minus 110326-110491 TABLE 52A : ABOUT 204 GENES UPREGULATED IN PRIMARY MELANOMAS RELATIVE TO MELANOMA METASTASES Table 52A lists about 204 genes upregulated in primary melanomas relative to melanoma metastases. Genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value rejecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : 90th percentage of primary melanoma Als divided by the 90th percent of melanoma metastasis Ais R2 : 90th percentile of primary melanoma Als divided by the 90th percent of melanoma metastasis Als, where the 15th percentile of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 421948 L42583 Hs. 334309 kera6n 6A 21. 90 16. 66 422168 AA586894 Hs. 112408 S100calcium-bindingproteinA7 (psonas 21. 36 43. 65 401781 Target Exon 18. 70 18. 58 401780 NM 005557' : Homo sapiens keratin 16 (foca 15. 34 16. 00 431360 NM000427 Hs. 251680 iohcrin 12. 34 9. 86 409632 W74001 Hs. 55279 serine (or cysteine) proteinase inhibito 11. 24 8. 73 412636 NM 004415 desmoplakin (DPI, DPII) 11. 20 6. 62 417366 BE185289 Hs. 1076 small proline-rich protein 18 (comifin) 10. 46 12. 75 409601 AF237621 Hs. 80828 keratin 1 (epidermolytic hyperkeratosis) 10. 41 25. 49 420859 AW468397 Hs. 100000 S100 calcium-binding protein A8 (calgran 9. 20 8. 63 420783 A1659838 Hs. 99923 iec6n, galactoside-binding, soluble, 7 8. 11 11. 14 422511 AU076442 Hs. 117938 collagen, type XVII, alpha 1 7. 90 8. 92 422158 L10343 Hs. 112341 protease inhibitor 3. skin-derived (SKAL 7. 14 22. 14 427666 A1791495 Hs. 180142 catmodulin-like skin protein (CLSP) 7. 03 8. 90 430686 NM 001942 Hs. 2633 desmoglein 1 6. 88 5. 39 431369 BE184455 Hs. 251754 secetoryleukocyteproteaseinhibitor (6. 60 12. 79 456525 AW468397 Hs. 100000 S100calcium-bindingproteinA8 (calgran 6. 44 6. 19 437191 NM006846 Hs. 331555 sedne protease inhibitor, Kazal type, 5 6. 34 7. 77 422166 W72424 Hs. 112405 S100calcium-bindingproteinA9 (caigran 6. 15 8. 91 418067 Al127958 Hs. 83393 cysta6n EIM 6. 08 9. 24 408536 AW381532 Hs. 135188 ESTs 6. 04 17. 40 402075 ENSP00000251056' : Plasma membrane calcium 5. 96 8. 41 413554 AA319146 Hs. 75426 secretogranin 11 (chromogranin C) 5. 46 3. 32 410001 AB041036 Hs. 57771 katlikein 11 5. 38 5. 36 421100 AW351839 Hs. 124660 Homo sapiens cDNA : FLJ21763 fis, clone C 5. 32 3. 84 407788 BE514982 Hs. 38991 S100 calcium-binding protein A2 5. 19 5. 30 419329 AY007220 Hs. 288998 S100-type calcium binding protein A14 5. 03 7. 94 429504 X99133 Hs. 204238 lipocalin 2 (oncogene 24p3) (NGAL) 4. 86 5. 22 421773 W69233 Hs. 112457 ESTs 4. 82 12. 41 442577 AA292998 Hs. 163900 ESTs 4. 82 4. 40 401760 Target Exon 4. 60 11. 03 408522 Ai541214 Hs. 46320 Small proline-rich protein SPRK [human, 4. 50 11. 35 417515 L24203 Hs. 82237 ataxia-telangiectaiagroupD-asociated 4. 47 12. 43 431211 M86849 Hs. 323733 gap junction protein, beta 2, 26kD (conn 4. 45 2. 99 446989 AK001898 Hs. 16740 hypothetical protein FLJ11036 4. 39 4. 23 423017 AW178761 Hs. 227948 serine (or cysteine) proteinase inhibito 4. 38 4. 55 418663 AK001100 Hs. 41690 desmocollin 3 4. 36 5. 16 424620 AA101043 Hs. 151254 kallikein7 (chymotrypUc, stratumcom 4. 29 5. 19 401747 Homo sapiens keratin 17 (KRT17) 4. 28 5. 41 414807 A1738616 Hs. 77348 hydroxyprostaglandin dehydrogenase 15 ; N 4. 24 2. 30 411274 NM002776 Hs. 69423 kallikrein 10 4. 22 4. 82 439496 BE616501 Hs. 32343 Homosapiens Similar10RIKENcDNA1110 4. 21 8. 26 420039 NM 004605 Hs. 94581 sulfotransferase family, cytosolic, 2B, 4. 18 4. 73 429538 BE182592 Hs. 139322 small proline-rich protein 2A 4. 16 7. 30

418686 Z36830 Hs. 87268 annexin A8 4. 12 4. 09 407366 AF026942 Hs. 17518 gb : Homo sapiens cig33 mRNA, partial sequ 4. 08 2. 13 421733 AL119671 Hs. 1420 fibroblast growth factor receptor 3 (ach 4. 08 4. 38 416091 AF295370 Hs. 283082 defensin, beta 3 4. 05 5. 38 442757 A1739528 Hs. 28345 ESTs 3. 94 4. 28 427318 AF186081 Hs. 175783 zinc transporter 3. 92 3. 07 453309 A1791809 Hs. 32949 defensin, beta 1 3. 90 4. 30 422192 AA305159 Hs. 1 13019 fis485 3. 88 2. 81 424012 AW368377 Hs. 137569 tumor protein 63 kDa with strong homolog 3. 86 5. 03 429365 AA451798 Hs. 99249 ESTs 3. 76 4. 05 423634 AW959908 Hs. 1690 heparin-binding growth factor binding pr 3. 72 6. 35 425580 L11144 Hs. 1907 galanin 3. 68 3. 65 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 3. 68 2. 75 444946 AW139205 Hs. 156457 hypothetical protein FU22408 3. 59 5. 72 408591 AF015224 Hs. 46452 mammaglobin 1 3. 58 4. 73 431009 BE149762 Hs. 48956 gap junction protein, beta 6 (connexin 3 3. 58 2. 62 438501 Z44110 Hs. 86149 phosphoinositol -phosphate-binding prot 3. 56 2. 61 421574 AJ000152 Hs. 105924 defensin, beta 2 3. 56 4. 04 402294 Target Exon 3. 48 4. 38 428666 AL080190 Hs. 189242 Homo sapiens mRNA ; cDNA DKFZp434A202 (fr 3. 44 Z95 401785 NM002275* : Homo sapiens keratin 15 (KRT1 3. 42 4. 92 418007 M13509 Hs. 83169 matrix metalloproteinase 1 (inters6Gal 3. 36 4. 24 418394 AF132818 Hs. 84728 Kruppel-like factor 5 (intesfinal) 3. 31 5. 42 452392 L20815 Hs. 507 comeodesmosin 3. 30 8. 56 445183 AB007877 Hs. 12385 KIAA0417 gene product 3. 30 2. 35 433124 U51712 Hs. 13775 hypothetical protein SMAP31 3. 26 2. 15 419098 AA234041 Hs. 87271 ESTs 3. 25 4. 34 421978 AJ243662 Hs. 110196 NICE-1 protein 3. 17 5. 86 445493 Ai915771 metallothionein I E (funcfional) 3. 16 2. 98 448111 AA053486 Hs. 20315 interferon-induced protein with tetratri 3. 14 2. 07 445745 AB007924 Hs. 13245 KIAA0455 gene product 3. 10 2. 39 410268 AA316181 Hs. 61635 six transmembrane epithelial anfigen of 3. 06 2. 71 407839 AA045144 Hs. 161566 ESTs 3. 06 3. 54 432374 W68815 Hs. 301885 HomosapienscDNAFW11346fis, clonePL 3. 04 4. 64 439706 AW872527 Hs. 59761 ESTs, Weakly similar to DAP1HUMAN DEATH 3. 04 2. 78 452240 A1591147 Hs. 61232 ESTs 3. 00 4. 79 409190 AU076536 Hs. 50984 sarcoma amplified sequence 2. 96 3. 05 408015 AW136771 Hs. 244349 epidermal differentiation complex protei 2. 94 10. 53 420798 W93774 Hs. 99936 keratin 10 (epidermolytic hyperkeratosis 2. 91 3. 01 406964 M21305 FGENES predicted novel secreted protein 2. 90 5. 34 451541 BE279383 Hs. 26557 plakophilin 3 2. 89 6. 64 454027 R40192 Hs. 21527 Human DNA sequence from clone GS1-11SM3 2. 86 2. 81 414737 A1160386 Hs. 125087 ESTs 2. 84 1. 76 428330 L22524 Hs. 2256 matrix metalloproteinae 7 (matrilysin, 2. 82 1. 83 405542 Target Exon 2. 80 2. 77 442503 AF147078 Hs. 150853 p53-responsive gene 5 2. 78 5. 17 402970 C20000886* : gil92805631gblAAF86472. 11 (AF 2. 78 3. 37 416730 T99937 gb : ye72dO4. r1 Scares fetal liver spleen 2. 76 2. 76 433435 BE545277 Hs. 340959 Tstranstationetongation factor, mitoch 2. 75 2. 76 447164 AF026941 Hs. 17518 vipirin ; similar to inflammatory respon 2. 72 2. 86 409453 A1885516 Hs. 95612 ESTs 2. 70 6. 68 428824 W23624 Hs. 173059 ESTs 2. 67 2. 75 437233 D81448 Hs. 339352 Homo sapiens brother of CDO (BOC) mRNA, 2. 65 3. 07 430630 AW269920 Hs. 2621 cysia6n A (slefin A) 2. 63 2. 38 433339 AF019226 Hs. 8036 glioblastoma overexpressed 2. 61 2. 44 444670 H58373 Hs. 332938 hypothefical protein MGC5370 2. 57 1. 74 414602 AW630088 Hs. 76550 HomosapiensmRNA ; cDNADKFZpS6481264 ( 2. 54 3. 66 400995 C11000295-: gil12737279lrefl, XP_012163. 1l 2. 54 2. 93 423515 AA327017 Hs. 176594 ESTs 2. 53 7. 36 417359 T99264 Hs. 191117 ESTs 2. 53 2. 54 432426 AW973152 Hs. 31050 ESTs 2. 52 2. 15 413822 R08950 Hs. 272044 ESTs, Weakly similar to ALU 1-H U MAN ALU S 2. 52 3. 05 414987 AA524394 Hs. 294022 hypothetical protein FLJ14950 2. 52 3. 85 407748 AL079409 Hs. 38176 KIAA0606 protein ; SCN Circadian Oscillat 2. 48 1. 76 426990 AL044315 Hs. 173094 Homo sapiens MRNA for KIAAL 750 protein, 2. 47 1. 92 413392 AW021404 Hs. 13021 ESTs 2. 47 2. 56 442762 AF035119 Hs. 8700 deleted in liver cancer 1 2. 46 1. 90 444781 NM014400 Hs. 11950 GPI-anchored metastasis-associated prote 2. 46 7. 90 424364 AW383226 Hs. 163834 ESTs, Weakly similar to G01763 atrophin-2. 46 2. 66 420568 F09247 Hs. 247735 protocadherin alpha 10 2. 46 3. 01 405885 Targel Exon 2. 46 2. 82 412633 AF001691 Hs. 74304 periplakin 2. 46 5. 01 429852 AB010445 Hs. 225948 small inducible cytokine subfamily A (Cy 2. 45 3. 35 429624 AA458648 Hs. 99476 ESTs, Weakly similar to 13131848 atphat 2. 44 2. 33 407325 AA291180 Hs. 328476 ESTs, Weakly similar to alternatively sp 2. 44 2. 11 431441 U81961 Hs. 2794 sodium channel, nonvoltage-gated 1 alpha 2. 43 3. 66 432543 AA552690 Hs. 152423 Homo sapiens cDNA : FLJ21274 fis, clone C 2. 42 3. 12 430168 AW968343 Hs. 145582 DKFZP43411735 protein 2. 41 2. 75 408000 L11690 Hs. 198689 bulious pemphigoid anfigen 1 (230/240kD) 2. 40 3. 67 404049 NM018937' : Homo sapiens protocadherin be 2. 39 1. 89 433576 BE080715 Hs. 161091 ESTs 2. 39 1. 59 444083 AH23195 gb : oo17a10. xl Soares_NSF_F8 9W_OT_PA P S 2. 38 2. 59 408208 BE018717 ESTs 2. 37 2. 12

431842 NM005764 Hs. 271473 epithelial protein up-regutated in carci 2. 36 2. 23 453931 AL121278 Hs. 25144 ESTs 2. 34 1. 99 452308 Api167560 Hs. 61297 ESTs 2. 31 3. 82 431048 R50253 Hs. 249129 cell death-inducing DFFA-like effector a 2. 31 2. 18 403752 NM 002753' : Homo sapiens mitogen-activate 2. 30 2. 38 402525 NM W2699-: Homo sapiens POU domain, da 2. 30 2. 36 420223 N27807 dbosomal protein L4 2. 30 1. 73 452023 AB032999 Hs. 27566 KIAAI 173 protein 2. 29 4. 54 443172 AW662964 Hs. 199061 p300/CBP-associatedfactor 2. 28 2. 02 439979 AW600291 Hs. 6823 hypothetical protein FU10430 2. 28 1. 71 414004 AA737033 Hs. 7155 ESTs, Moderately similar to 2115357A TYK 2. 27 1. 81 429554 NM 012275 Hs. 207224 inteneukinl. delta 2. 26 2. 17 436895 AF037335 Hs. 5338 carbonic anhydrase XII 2. 26 2. 51 404029 NM_018936-: Homosapiensprotocadherinbe 2. 26 2. 19 424049 AB014524 Hs. 138380 KIAA0624 protein 2. 26 2. 99 442423 BE326264 Hs. 246842 ESTs 2. 26 1. 75 408452 AA054683 Hs. 192455 ESTs, WeaklysimilartoALU7_HUMANALUS 2. 26 2. 29 428471 X57348 Hs. 184510 stratfin 2. 25 2. 40 410541 AA065003 Hs. 64179 syntenin-2 protein 2. 24 2. 46 415539 Ai733881 Hs. 72472 8MP-R18 2. 22 1. 64 425701 AA361850 Hs. 240443 Human clone 137308 MRNA, partial cds 2. 22 3. 04 423973 AF038461 Hs. 136574 arachidonate 12-lipoxygenase, 12R type 2. 22 3. 24 409178 BE393948 Hs. 50915 kallikrein 5 2. 19 4. 74 433091 Y12642 Hs. 3185 lymphocyte antigen 6 complex, locus D 2. 19 7. 96 430171 AF086289 Hs. 234766 skin-specific protein 2. 17 3. 56 401994 Target Exon 2. 14 3. 34 449228 AJ403107 Hs. 148590 protein related with psoriasis 2. 11 5. 52 446292 AF081497 Hs. 279682 Rh type C glycoprotein 2. 11 5. 78 426150 NM 003658 Hs. 167218 BarH-like homeobox 2 2. 05 2. 96 452554 AW452434 Hs. 58006 ESTs, WeaklysimilartoALU5_HUMANALUS 2. 04 4. 17 443162 T49951 Hs. 9029 DKFZP434G032 protein 1. 98 3. 20 400304 AF005082 Hs. 113261 Homo sapiens skin-specific protein (xp33 1. 94 3. 20 407395 AF005082 gb : Homo sapiens skin-specific protein (x 1. 92 3. 24 412507 L36645 Hs. 73964 EphA4 1. 92 3. 06 410310 J02931 Hs. 62192 coagulation factor III (thromboplastin, 1. 90 3. 18 425415 M13903 Hs. 157091 involucrin 1. 89 5. 26 417324 AW265494 ESTs 1. 88 3. 82 412446 Al768015 ESTs 1. 88 3. 36 451092 A1207256 Hs. 13766 Homo sapiens mRNA for FLJ00074 protein, 1. 87 3. 75 444726 NM 006147 interferon regulatory factor 6 1. 86 4. 11 424399 A1905687 A1905687 : IL-BT095-190199-019 BT095 Homo 1. 85 4. 20 434346 AA630445 ESTs 1. 84 3. 08 446051 BE048061 Hs. 37054 ephrin-A3 1. 83 3. 44 423725 AJ403108 Hs. 132127 hypothetical protein LOC57822 1. 78 3. 45 413859 AW992356 Hs. 8364 Homo sapiens pyruvate dehydrogenase kina 1. 76 2. 99 411908 L27943 Hs. 72924 cytidine deaminase 1. 74 3. 60 445656 W22050 Hs. 21299 ESTs, Weakly similar to AF1518401 CGI-8 1. 71 3. 56 413966 AA133935 Hs. 173704 ESTs, Moderately similar to A53959 throm 1. 71 3. 38 424046 AF027866 Hs. 138202 serine (orcysteine) proteinase inhibito 1. 70 3. 92 425650 Nom-001944 Hs. 1925 desmoglein 3 (pemphigus vulgaris antigen 1. 68 3. 25 429299 A1620463 Hs. 347408 hypothetical protein MGC13102 1. 67 2. 92 429002 AW248439 Hs. 2340 junction plakoglobin 1. 66 3. 35 421335 X99977 Hs. 103505 ARS component B 1. 66 4. 31 433662 W07162 Hs. 150826 RAB25 RAB25, member RAS oncogene family 1. 65 3. 55 429211 AF052693 Hs. 198249 gap junction protein, beta 5 (connexin 3 1. 64 4. 04 414214 D49958 Hs. 75819 glycoprotein M6A 1. 64 3. 59 437897 AA770561 Hs. 146170 hypothe6calprotein FW22969 1. 62 3. 13 426350 NM_003245 Hs. 2022 Uansglulaminase 3 (E polypeptide, prote 1. 62 2. 92 413163 Y00815 Hs. 75216 protein tyrosine phosphatase, receptor t 1. 57 3. 09 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 1. 53 3. 39 427751 AF000152 conserved gene amplified in osteosarcoma 1. 52 3. 53 416881 N32520 Hs. 141358 ESTs 1. 52 3. 06 435013 H91923 Hs. 110024 NM020142 : HomosapiensNADH : ubiquinone o 1. 49 2. 91 434574 A1424458 Hs. 33470 ESTs 1. 48 3. 05 454478 AW805749 superoxide dismutase 2, mitochondrial 1. 48 3. 54 447330 BE279949 Hs. 18141 ladinin 1 1. 46 4. 48 414583 AA362907 Hs. 76494 proline arginine-rich end leucine-rich r 1. 41 2. 99 433640 AW390125 Hs. 240443 Homo sapiens cDNA : FLJ23538 fis, clone L 1. 40 3. 71 427461 AA531527 Hs. 332040 hypothetical protein MGC1 3010 1. 36 2. 98 430205 AB025904 Hs. 235168 carbonic anhydrase XIV 1. 36 3. 14 450796 NM 001988 Hs. 25482 envoplakin 1. 34 3. 74 407394 AF005081 gb : Homo sapiens skin-specific protein (x 1. 30 3. 26 430513 AJ012008 Hs. 241586 G6C protein 1. 28 3. 26 411388 X72925 Hs. 69752 desmocoSlin 1 1. 22 3. 64 431089 BE041395 ESTs. Weakly similar to unknown protein 1. 14 3. 71 444107 T46839 Hs. 10319 UDP glycosyltransferase 2 family, polype 1. 00 3. 20 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 1. 00 3. 26 TABLE 528 : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers

Pkey CAT Number Accession 412636 1438 1 M77830 NM004415AF139065 BG681115BG740377 B1712964 BG000656AA128470 B ! 438324 H27408 BE931630 BE167165 AW370827 AW370813 J05211 BG698865 BG740734 BG680618 BG739778 81765807 BM353403 BM353248 AW177784 AW205789 AW951576 AW848592 BE182164 BF149266 BE940187 B1060445 81060444 BF350983 BE720095 BE720069 BE715154 BE082584 BE082576 BE004047 AA857316 81039774 BE713818 BE713548 AW170253 BE160433 B1039775 AW886475 BM462504 BE931734 BF149264 AA340777 BF381183 BG621737AU127260AW364859 BF993352 BG223489 BE819009 BF381184 BE715956 R58704 AA852212 AW366566 Bl090358 BF087707 BE819046 BE819005 AA377127 BE073467 BE819069 BE819048 B1036306 BG990973 Bl040954 BF919911 AU140155 At951766 AI434518 AW804674 BF752969 BE837009 BE925826 BF149265 AW995615 BE814264 Bol039782 AU140407 BE144243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF086994 BF592276 BE082507 BE082514 BE082505 BF873693 AW068840 AW847678 BF804153 AW365157 BE813930 BE002030 AW365153 BE184941 BF749421 BE184920 BF839562 BE184933 BF842254 BE698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 W39488 C04715 BF096124 BE865341 AW799304 AL603116 BE149760 BE705967 BE705966 BE705968 AW848723 AW376699 AW376817 AW376697 BG005097 BF751115 BE696084 AW848371 AW376782 AW848789 AW849074 AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 BG005197 BF350086 BE715196 BE715155 BF752396 BF093817 BF831190 BF752409 BE006561 BG959922 BF094833 BF094748 BF094583 AW377699 AW607238 BE082519 AW377700 BF349467 A1190590 AI554403 AI392926 AU158477 81467252 AU159919 AI760816 BF082516 AI439101 AA451923 AI340326 AI590975 81791553 AI700963 Al142882 AA039975 AA946936 AA644381 BM314884 AA702424 Al417612 AW190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW166807 Api346078 W95070 AA149191 AA026864 Api830049 AW780435 A1078449 At819984 Al858282 Bl468588 Al860584 Al025932 M026047 AA703232 AA658154 AA515500 AW192085 AA918281 T77861 AI927207 AI205263 BF082491 AW021347 Al568096 BE939862 AA088866 D12062 AA056527 AA782109 W19287 W02156 AW150038 AA022701 T87181 H44405 AI910434 BF082513 AI494069 AI270027 AI635878 AA128330 BG681425 BE706078 R20904 BG680059 BG676647 BF764409 AA026654 AV745530 Bol762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 AI571075 BE067786 AVT21320 A1022862 N29754 C03378 N84767 AA131077 H30146 BE714290 A1686869 A1568892 A1915596 AW105614 A1887258 A1538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 Api905927 BF992780 AW853812 BG954443 Bl770853 BG679406 BG740832 BG681087 BG698430 AA455100 T87267 BE696209 BE696210 B1089483 BE006273 BE872225 AW391912 BE925515 BG677012 BG741970 AA026480 BE705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 B1040941 AA337270 AW384371 AW847442 B1058659 BE813665 W95048 W25458 AW177786 AA025851 BE931733 BF154837 BG949393 BE714441 AW996245 BE711801 AI284090 BE064323 BE719390 BE940148 Bug991212 BF375714 BF349522 BG996267 T48793 Bl013292 BE001925 AW365156 AW365154 AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W38382 AI498487 445493 423456 1 AV711317 A1809938 A1808768 A1240593 A1915771 416730 1988296-1 H80564 T99937 T70802 444083 10908 12 B1836699 A1123195 408208 642734_1 Bl757837 AW439843 AW172765 BE018717 BE464329 BE302285 H96902 BF477981 BE674508 BE670755 H95980 T15387 420223 191648_1 N27807 AA256634 BE276324 417324 292720J BG775668 BG680336 AW991605 AA455904 AW265494 AW265432 BF911380 AA456370 BF9) 1379 AA195677 BF914311 BF913866 BG775059 BG951874 A1572169 412446 634671 BC021735 AI669212 AL120184 AI769949 BE701002 BE184363 BE819031 BG702238 BF090049 BF963318 BF961912 BF943013 AA934514 AA151245 8F960659 AA987907 Z41449 Bof908059 BF908053 BF908049 BE699424 BF908060 BF962832 BF952020 BF963134 81035538 8F908052 BF908057 BF090026 BF943158 A1632924 BF512340 BF952021 BF960776 BF943437 BF942847 A1768015 F09778 F04816 F02721 AA102645 A1633838 AA617929 BF947001 B1035448 BE935876 AW890837 AW898604 BF957405 BF963433 BG704815 444726 35032 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 A1745383 AU159045 A1693500 AW293668 AW371408 BE856107 A1338042 AW188320 AI698246 BE673290 AW297653 AA156532 A1017342 AI916754 AI190644 AI184302 AA857671 BE857018 AI307420 AI318157 AW204327 AW664668 AW274339 AA582788 AI345741 AW301433 AI873468 AW137388 BF718731 BF718413 AA877495 BF001575 AI824693 AW849604 AW849405 AW849396 AW849173 BE673179 Al611327 M705753 BE715478 AW849414 AW849399 A1085759 AI140849 T67412 AI889885 AW104647 Al912495 Al889874 Al744241 BE717113 BE717108 BE715564 AI872527 AA029457 C00338 AI469558 BE715577 AA045413 BF843813 424399 2196_1 NM 058173 AF414087 W72837 BF742809 AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 8G202312 W72838 AI139456 BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 AI127172 BE815819 AI905624 R75793 BG202313 A1905837 8E815853 434346 MH1094 14 AK056896 AI924216 AI660493 AI984141 AI991272 AA593860 AI983793 AI346155 AI274929 AI2812t 1 AI821178 BC020841 BF352476 BF843140 BF917041 W80832 AA630445 BF350167 BE162052 BE931808 A1572329 BG536379 427751 15028_1 BE875818 AW751975 W39241 BF808798 W22600 BF082190 AA031290 R42801 H98235 H17925 A1631236 A1933786 H42736 AF000152 AU123911 AW410526 BM354207 BF800492 BM142340 BE019322 AL597008 AW327818 81041915 AW504825 AW504941 BF987969 NM 005730 U81556 AI422831 AUt 54008 AA147822 AA873109 A1089244 AI360868 AW168024 AI819848 AA811327 AI355616 AA281629 AI880578 AI274316 AW014622 AI268660 AI270283 AA171981 AI349410 AA402469 AI421985 A1004864 AI423497 AI361503 AI363096 AW805345 AL539979 AA553967 AW502264 Al290698 N22420AI281054 Al500699AW342095 C75122 AW504577 Al130811 Al423567 R79086 AI860451 BE222885 AI697830 AI279575 BF438693 AW576277 BE218210 AI952376 AA506609 AI147566 AI391690 AA991622 AI696368 A1784664 AA741555 AI002681 AW474554 AW474508 D25623 AI493929 AA179800 W73566 AW411368 AA147971 AA088581 BF804510 AU145809 AU148108 AA223219 AU757840 AW169757 AI537862 N42341 Al 128667 AW327853 AA713915 W 15255 W567d3 AA058322 H81878 AA723464 N27523 R37745 AA613566 AL526353 AI905211 BF802713 N40338 AA249397 BF752939 BE250441 H64761 BF853011 H81877 H96088 AL576453 W73585 H39990 AW438965 BF899684 A1040299 AL561879 AA293821 H27760 BC018922 AL533396 BE5135aO BF432649 A1884985 AA404264 AW024396 AW167863 AW027036 Al302177 Al660487 AW026086 BF432564 BF091011 A1193156 AA744623 A1859510 B1063081 B1061541 AA777036 BG058486 B1063555 A1349411 BF874521 AW139801 A1268585 AA401267 Al905209 R64276 N72043 AF022231 B1256540 AU134437 BG826972 BE298386 AW134499 AW206089 BF846730 AW500331 BF849336 81041697 AI857745 AW192840 AW410527 AI697435 AW006631 AW504124 AL048926 A1085476 AW327855 AA459344 AW207516 AW204875 BM142514 BF436650 AA960980 AW242609 Bt012363AW837102 BE703126 BE814612 BE837981 BE703141 BF343101 R47375 AA031413 N40264 BG027363 BF526360 BE391263 AA280192 BE294042 BE250630 AU147734 AU146610 AA196787 N59465 AW575791 H16738 H96089 H64762 AW006603 BE857292 Al719393 AU155418 BG770385 AA339673 BG337748 H42694 BE834346 AA090896 BE619985 BM006968 R46008 BF304621 AA172280 AW957721 BF304885 BF933455 BF809973 BG386280 AW079808 T51091 AL520569 BE694350 T06360 BF347780 BE560703 BE296629 454478 4273 16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 407394 27110_2 AF005081 BG193B48 431089 125941_2 BG940189 AW063489 AA715980 BF001091 BF880066 AA666102 AA621946 AA491826 TABLE 52C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et ai. ewers to the publication entitted The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_posibon : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 401781 7249190 Minus 83215-83435, 83531-83656, 83740-83901, 8423 401780 7249190 Minus 28397-28617. 28920-29045, 29135-29296, 2941 402075 8117407 Plus 121907-122035, 122804-122921, 124019-12416 401760 9929699 Plus 83126-83250, 85320-85540, 94719-95287

401747 9789672 Minus 118596-118816, 119119-119244, 119609-11976 402294 2282012 Minus 2575-3000 401785 7249190 Minus 165776-165996, 166189-166314, 166408-16656 405542 9857564 Plus 71331-72183 402970 9650703 Minus 124891-125049 400995 8099094 Plus 14118&14t601 405885 7677703 Minus 42574-42998 404049 3688074 Minus 75765-78155 403752 7678857 Plus 33704-33828 402525 9800048 Minus 19748-20683 404029 7671252 Plus 108716-111112 401994 4153858 Minus 42904-43124, 43211-43336, 44607-44763. 4519 TABLE 53A : ABOUT 298 GENES UPREGULATED IN MELANOMA METASTASES RELATIVE TO PRIMARY MELANOMAS Table 53A lists about 298 genes upregulated in melanoma metastases relative to primary melanomas. Genes were selected from 59680 probesets on the Eos/Affymethx Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene 6Ue RI 90th percentile of melanoma metastasis Als divided by the 90th pencen61e of primary melanoma Als R2 90th percentile of melanoma metastasis Als divided by the 90th percentile of primary melanoma Als, where the 15th percentage of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Tite R1 R2 407245 X90568 Hs. 172004 titin 10. 56 11. 32 412228 AW503785 Hs. 73792 complementcomponent (3d/EpsteinBarrvi 9. 22 6. 14 426752 X69490 Hs. 172004 titin 8. 78 10. 44 418310 AA814100 Hs. 86693 ESTs 8. 65 6. 49 414522 AW518944 Hs. 76325 Immunoglobulin J chain 8. 37 4. 39 433447 U29195 Hs. 3281 neuronal pentraxin 11 8. 27 7. 25 456373 BE247706 Hs. 89751 membrane-spanning 4-domains, subfamily A 7. 78 6. 70 425545 N98529 Hs. 158295 Homo sapiens, clone MGC : 12401, mRNA, com 7. 49 9. 02 428087 AA100573 Hs. 182421 troponin C2, fat 7. 45 7. 65 436485 X59135 Hs. 156110 immunoglobulin kappa constant 7. 35 6. 18 414646 AA353776 Hs. 901 CD48 antigen (8-cell membrane protein) 6. 97 5. 75 412519 AA196241 Hs. 73980 troponin T1, skeletal, slow 6. 15 6. 33 430280 AA361258 Hs. 237868 interieukin 7 receptor 6. 07 3. 11 449078 AK001256 Hs. 22975 KIAA1576 protein 6. 05 8. 55 437952 D63209 Hs. 5944 solutecanier family 11 (proton-coupled 6. 03 5. 36 412561 NM002286 Hs. 74011 lymphocyte-activation gene 3 5. 85 5. 57 431574 AW572659 Hs. 261373 hypothetical protein dJ434014. 3 5. 74 6. 40 458079 A1796870 Hs. 54277 DNA segment on chromosome X (unique) 992 5. 72 4. 76 417880 BE241595 Hs. 82848 selectin L (lymphocyte adhesion molecule 5. 71 5. 00 429412 NM006235 Hs. 2407 POU domain, class 2, associating factor 5. 69 3. 84 420338 AA825595 Hs. 88269 Homo sapiens, clone MGC : 17339, mRNA, com 5. 37 4. 12 430580 AA806105 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 5. 31 6. 02 428804 AK000713 Hs. 193736 hypothetical protein FLJ20706 5. 29 7. 97 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-5. 26 2. 93 445784 A1253155 Hs. 146065 ESTs 5. 12 3. 10 409461 AA382169 Hs. 54483 N-myc (and STAT) interactor 5. 05 3. 41 414020 NM002984 Hs. 75703 small inducible cytokine A4 (homologous 4. 59 4. 00 420301 AA767526 Hs. 22030 paired box gene 5 (B-cell lineage specif 4. 47 3. 92 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 4. 46 3. 61 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 4. 37 3. 22 414829 AA321568 Hs. 77436 pleckstrin 4. 35 3. 35 417878 U90916 Hs. 82845 Homo sapiens cDNA : FLJ21930 fis, clone H 4. 35 2. 68 422603 BE242587 Hs. 118651 hematopoietically expressed homeobox 4. 27 2. 67 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 4. 27 3. 67 441623 AA315805 desmoglein 2 4. 24 3. 66 422241 Y00062 Hs. 170121 protein tyrosine phosphatase, receptor t 4. 22 3. 60 417022 NM_014737 Hs. 80905 Ras association (RaIGDSIAF-6) domain fam 4. 20 2. 58 426317 AA312350 Hs. 169294 transcrip60nfætor7 (T-cellspecific, 4. 16 5. 82 430770 AA765694 Hs. 123296 ESTs 4. 15 5. 10 420931 AF044197 Hs. 100431 small inducible cytokine B subfamily (Cy 4. 12 5. 06 406707 S73840 Hs. 931 myosin, heavy polypeptide 2, skeletal mu 4. 11 3. 82 444863 AW384082 Hs. 104879 serine (or cysteine) proteinase inhibito 4. 10 2. 68 432306 Y18207 Hs. 303090 protein phosphatase 1, regulatory (inhib 4. 04 4. 10 417105 X60992 Hs. 81226 CD6 antigen 4. 03 4. 51 409041 AB033025 Hs. 50081 Hypothetical protein, XP 051860 (KIAAt 19 4. 02 3. 72 432485 N90866 Hs. 276770 CDW52 antigen (CAMPATH-1 antigen) 3. 99 4. 87 415165 AW887604 Hs. 78065 complement component 7 3. 97 3. 98 421181 NM 005574 Hs. 184585 LlMdomainonly2 (rhomboUn-like1) 3. 96 3. 19 421712 AK000140 Hs. 107139 hypothetical protein 3. 95 7. 34 408380 AF123050 Hs. 44532 diubiquitin 3. 94 2. 45 422423 AF283777 Hs. 116481 C072 antigen 3. 93 3. 29 408989 AW361666 Hs. 49500 KIAA0746 protein 3. 90 3. 02 424321 W74048 Hs. 1765 lymphocyte-specific protein tyrosine kin 3. 84 3. 40 420137 AA306478 Hs. 95327 CD30 antigen, delta polypeptide (TiT3 co 3. 84 4. 84 424922 BE386547 Hs. 217112 hypothetical protein MGC10825 3. 78 3. 04 400440 X83957 Hs. 83870 nebulin 3 77 4. 89

418870 AF147204 Hs. 89414 chemokinefC-X-C motif), receptor 4 (fus 3. 74 3. 91 450293 N36754 Hs. 171118 hypothetical protein FU00026 3. 74 2. 89 432606 NM 002104 Hs. 3066 granzyme K (serine protease, granzyme 3 : 3. 72 2. 65 408548 AA055449 Hs. 63187 ESTs, WeaklysimilartoALUC_HUMAN ! ! ! ! 3. 72 2. 43 429490 Al971131 Hs. 23889 ESTs. Weakly similar to AlU7 HUMAN ALU S 3. 71 2. 23 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 3. 70 2. 36 419749 X73608 Hs. 93029 sparc/osteonectin, cwcv and kazal-like d 3. 67 3. 30 410016 AA297977 Hs. 57907 small inducible cytokine subfamily A (Cy 3. 67 6. 72 433658 L03678 Hs. 156110 immunoglobulin kappa constant 3. 66 2. 49 424153 AA451737 Hs. 141496 MAGE-like 2 3. 64 2. 65 421666 AL035250 Hs. 1408 endothelin 3 3. 64 5. 92 417696 BE241624 Hs. 82401 CD69 antigen (p60, eady T-cell mfivab 3. 61 2. 69 429732 U20158 Hs. 2488 iymphocytecytosolicprotein2 (5H2doma 3. 60 1. 95 422173 BE385828 Hs. 250619 phorbolin-like protein MDS019 (CEM15) 3. 59 3. 08 413778 AA090235 Hs. 75535 myosin, light polypeptide 2, regulatory, 3. 57 11. 26 442379 Nom-004613 Hs. 8265 transglutaminase 2 (C polypep6de, prote 3. 56 4. 91 439859 AW292872 Hs. 124554 ESTs 3. 53 4. 15 453064 R40334 Hs. 89463 potassium large conductance calcium-acti 3. 51 2. 88 411252 AB018549 Hs. 69328 MD-2 protein 3. 46 1. 82 414324 Y14768 Hs. 890 lymphotoxin beta (TNF superfamily, membe 3. 45 4. 65 420286 A1796395 Hs. 111377 ESTs 3. 42 2. 47 413385 M34455 Hs. 840 indoleamine-pyrrole 2, 3 dioxygenase 3. 42 3. 09 442104 L20971 Hs. 188 phosphodiesterase 4B, cAMP-specific (dun 3. 41 Z22 405545 Target Exon 3. 40 2. 46 416373 AA195845 ESTs, Weakly similar to S12658 cysteine-3. 40 5. 64 417410 AF063020 Hs. 82110 PC4andSFRS1interæ6ngprotein1 3. 37 4. 27 418522 AA605038 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 3. 33 2. 37 433470 AW960564 transmembrane 4 superfamily member 1 3. 33 3. 13 416975 Nom004131 Hs. 1051 granzyme B (granzyme 2, cytotoxic T-lymp 3. 32 2. 51 442149 AB014550 Hs. 8118 KIAA0650 protein 3. 30 2. 29 411852 AA528140 Hs. 107515 ESTs, Weakly similar to T00329 hypotheti 3. 29 3. 85 447023 AA356764 Hs. 17109 integral membrane protein 2A 3. 24 2. 79 421566 NM 000399 Hs. 1395 early growth response 2 (Krox-20 (Drosop 3. 23 1. 78 414176 BE140638 Hs. 75794 EDG-2 (endothelial differentiation, lys 3. 22 2. 90 447513 AW955776 Hs. 313500 ESTs, Moderately similar to ALU7 HUMAN A 3. 18 4. 16 421893 NM 001078 Hs. 109225 vascular cell adhesion molecule 1 3. 17 3. 59 424148 BE242274 Hs. 1741 integrin, beta7 3. 14 2. 29 406648 AA563730 Hs. 277477 major histocompatibility complex, class 3. 13 3. 05 429505 AW820035 Hs. 278679 adisintegrinandmetalloproteinaedoma 3. 13 2. 36 446619 AU076643 Hs. 313 secreted phosphopnotein 1 (osteopon6n, 3. 12 2. 55 406704 M21665 Hs. 929 myosin, heavy polypep6de 7, cardiac mus 3. 12 5. 54 443885 H91806 Hs. 15284 ESTs 3. 08 3. 55 418203 X54942 Hs. 83758 CDC28 protein kinase 2 3. 08 2. 20 417640 D30857 Hs. 82353 protein C receptor, endothelial (EPCR) 3. 06 3. 21 447232 AW499834 Hs. 327 intedeukin 10 receptor, alpha 3. 05 3. 36 409103 AF251237 Hs. 112208 XAGE-1 protein 3. 04 2. 07 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy 3. 04 2. 24 421834 BE543205 Hs. 288771 DKFZP586A0522 protein 3. 03 1. 91 444666 BE293347 Hs. 11638 long-chain fatty acid coenzyme A ligase 3. 01 3. 43 425295 AA431366 Hs. 37251 ESTs 3. 01 3. 07 429109 AL008637 Hs. 196352 neutrophil cytosolic factor 4 (40kD) 2. 99 2. 55 420340 NM000734 Hs. 97087 CD3Z antigen, zeta polypeptide (TiT3 com 2. 98 5. 98 418968 NM 000078 Hs. 89538 cholesteryl ester transfer protein, plas 2. 97 2. 68 438914 N93892 Hs. 10727 ESTs 2. 97 2. 19 418391 NM3281 Hs. 84673 troponin 1, skeletal, slow 2. 96 2. 68 419056 M89957 Hs. 89575 CD79B antigen (immunoglobulin-associated 2. 96 3. 94 449523 NM 000579 Hs. 54443 chemokine (C-C motif) receptor 5 2. 96 4. 02 450847 NM 003155 Hs. 25590 stanniocalcin 1 2. 96 3. 24 418460 M26315 Hs. 85258 CD8 antigen, alpha polypeptide (p32) 2. 95 2. 73 426711 AA383471 Hs. 343800 conserved gene amplified in osteosarcoma 2. 94 2. 36 426559 AB001914 Hs. 170414 paired basic amino acid cleaving system 2. 93 2. 17 424528 AW073971 Hs. 238954 ESTs, Weakly similarto KIAA1204 protein 2. 93 2. 70 408633 AW963372 Hs. 46677 PR02000 protein 2. 92 2. 16 443195 BE148235 Hs. 193063 Homo sapiens cDNA FLJ14201 fis, clone NT 2. 92 2. 92 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypotheb 2. 90 2. 09 437802 At475995 Hs. 122910 ESTs 2. 90 3. 71 417771 AA804698 Hs. 82547 refinoic acid receptor responder (tazaro 2. 90 3. 56 438000 Al825880 Hs. 5985 non-kinase ! ector protein SPEC2 2. 90 2. 60 414555 N98569 Hs. 76422 phospholipase A2, group IIA (platelets, 2. 87 2. 07 421958 AA357185 Hs. 109918 ras homolog gene family, member H 2. 87 3. 48 420224 M84371 Hs. 96023 CD19 antigen 2. 86 4. 77 434883 AW381538 Hs. 19807 hypothetical protein MGC12959 2. 85 5. 44 452852 AK001972 Hs. 30822 hypothetical protein FU 11110 2. 84 2. 55 427527 A1809057 Hs. 153261 immunoglobulin heavy constant mu 2. 84 4. 16 446231 NM 002163 Hs. 14453 interferon consensus sequence binding pr 2. 83 2. 97 408838 A1669535 Hs. 40369 ESTs 2. 82 1. 82 429124 AW505086 Hs. 196914 minorhistocompabbilibanEgenHA-1 2. 82 4. 21 425023 AW956889 Hs. 154210 EDG-1 (endothelial differentiation, sph 2. 79 4. 00 425388 AA329384 Hs. 156110 immunoglobulin kappa constant 2. 79 2. 28 414290 A1568801 Hs. 71721 ESTs 2. 78 3. 19 418255 AW135405 Hs. 37251 ESTs 2. 76 3. 27 451952 AL120173 Hs. 301663 ESTs 2. 75 1. 74 424865 AF011333 Hs. 153563 lymphocyte antigen 75 2. 75 3. 10

409245 AA361037 URNA isopentenylpyrophosphate transfera 2. 74 2. 12 453920 A1133148 Hs. 36602 I factor (complement) 2. 74 3. 08 443968 AA287702 Hs. 10031 Kit0955 protein 2. 74 2. 34 434094 AA305599 Hs. 238205 hypothetical protein PR02013 2. 73 1. 67 436476 AA326108 Hs. 33829 bHLH prolein DEC2 2. 72 1. 70 428398 A1249368 Hs. 98558 ESTs 2. 72 2. 06 417141 U22662 nuclear receptor subfamily 1, group H, m 2. 70 2. 55 427080 AW068287 Hs. 301175 ras-related C3 botulinum toxin substrate 2. 69 3. 15 442485 BE092285 Hs. 29724 hypothetical protein Fou13187 2. 69 1. 99 429317 AA831552 Hs. 268016 Homo sapiens cDNA : FW21243fis, cloneC 2. 69 1. 70 443998 A1620661 Hs. 296276 ESTs 2. 69 2. 30 417542 J04129 Hs. 82269 progestagen-associated endometria prote 2. 68 3. 23 414291 A1289619 Hs. 13040 G protein-coupled receptor 86 2. 68 3. 01 448861 AL049951 Hs. 22370 Homo sapiens mRNA ; cDNA DKFZp56400122 (f 2. 66 2. 51 432435 BE218886 Hs. 282070 ESTs 2. 65 3. 28 430132 AA204686 Hs. 234149 hypothetical protein FU20647 2. 65 3. 04 427792 M63928 Hs. 180841 tumor necrosis factor receptor superfami 2. 64 3. 82 414696 AF002020 Hs. 76918 Niemann-Pick disease, type C1 2. 64 1. 94 420991 AW504814 Hs. 287379 HomosapiensmRNAforFWW111pnotein, 2. 64 2. 51 401566 NM005159 : Homo sapiens action. alpha, car 2. 63 3. 74 444119 R41231 Hs. 184261 ESTs, WeaklysimilartoT26686hypothe6 2. 63 2. 13 425231 M527161 ESTs 2. 61 2. 95 417427 M90391 Hs. 82127 interleukin 16 (lymphocyte chemoattracta 2. 61 1. 90 437669 Api358105 Hs. 123164 ESTs, Weakly similar to match to ESTs AA 2. 60 4. 45 413856 D13639 Hs. 75586 cyclin D2 2. 60 5. 71 407928 NM 002262 Hs. 41682 killer cell lecfin-like receptor subfami 2. 59 2. 68 443247 BE614387 Hs. 333893 c-Myc target JP01 2. 58 2. 77 447131 NM 004585 Hs. 17466 retinoic acid receptor responder (tazaro 2. 58 9. 28 443021 AA368546 Hs. 8904 Ig superfamily protein 2. 58 4. 49 424779 AL046851 Hs. 153053 CD37 antigen 2. 58 3. 88 425235 AA353113 Hs. 112497 HomosapienscDNA : FLJ22743 fis, clone H 2. 57 2. 09 424265 AF173901 Hs. 144287 hairylenhancer-of-split related with YRP 2. 57 3. 57 426780 BE242284 Hs. 172199 adenylate cyclase 7 2. 57 1. 86 452721 AJ269529 Hs. 301871 solute carrier family 37 (glycerol-3-pho 2. 56 2. 90 442904 AW575008 Hs. 11355 thymopoietin 2. 56 3. 39 433646 AA603319 Hs. 155195 ESTs 2. 54 2. 19 417289 D86962 Hs. 81875 growth factor receptor-bound protein 10 2. 53 4. 56 422640 M37984 Hs. 118845 troponinC, slow 2. 53 5. 38 448413 A1745379 Hs. 42911 ESTs 2. 53 2. 08 429536 AA873016 Hs. 206097 oncogene TC21 2. 52 2. 49 446272 BE268912 Hs. 14601 hematopoietic cell-specific Lyn substrat 2. 52 3. 46 424378 W28020 Hs. 167988 neural cell adhesion molecule 1 2. 52 2. 91 410257 BE244044 Hs. 61469 hypothetical protein 2. 51 3. 67 427609 AK000436 Hs. 179791 hypothetical protein FLJ20429 2. 51 3. 11 424868 A1568170 Hs. 96886 ESTs 2. 51 2. 30 418945 BE246762 Hs. 89499 arachidonate5-iipoxygenase 2. 50 2. 64 420899 NM001629 Hs. 100194 aræhidonate Slipoxygenase-æ6va6ng p 2. 50 3. 04 413441 AI929374 Hs. 75367 Src-like-adapter 2. 49 2. 37 414761 AU077228 Hs. 77256 enhancer of zeste (Drosophila) homolog 2 2. 49 1. 82 429493 AL134708 Hs. 145998 ESTs 2. 49 2. 40 419631 AW188117 popeye protein 3 2. 48 1. 85 437175 AW968078 Hs. 87773 protein kinase, cAMP-dependent, catalog6 2. 48 2. 32 421552 AF026692 Hs. 105700 secreted frizzled-related protein 4 2. 47 4. 17 420158 A1791905 Hs. 95549 hypothetical protein 2. 47 2. 62 453987 AA323750 Hs. 235026 Homo sapiens, clone MAGE : 4247529, mRNA, 2. 47 2. 49 429640 U83508 Hs. 2463 angiopoietin 1 2. 47 2. 57 437330 AL353944 Hs. 50115 Homo sapiens mRNA ; cDNA DKFZp761J1112 (f 2. 46 2. 42 426969 At936504 CDC-like kinase 1 2. 46 2. 41 427674 Nom-003528 Hs. 2178 H2BhistoneXamiiy, memberO 2. 46 2. 17 405547 NM018833' : Homo sapiens transporter 2, A 2. 46 2. 84 406678 U77534 gb : Human clone 1A11 immunoglobulin varia 2. 45 2. 89 407013 U35637 Hs. 83870 gb : Human nebulin mRNA, partial cds 2. 45 3. 40 428746 AW503820 Hs. 192861 Spi-B transcription factor (Spi-1/PU. tr 2. 43 6. 25 453953 AW408337 Hs. 36972 CD7 antigen (p41) 2. 39 4. 01 427759 BE245578 Hs. 2200 perforin 1 (pore forming protein) 2. 39 4. 56 443071 AL080021 Hs. 8986 complement component 1, q subcomponent, 2. 39 3. 31 437211 AA382207 Hs. 5509 ecotropic viral integration site 2B 2. 38 3. 15 440596 H13032 Hs. 103378 hypothetical protein MGC11034 2. 37 3. 68 452651 A1218918 Hs. 30209 KIAA0854 protein 2. 36 4. 08 421563 NM_006433 Hs. 105806 granulysin 2. 34 3. 25 421924 BE514514 Hs. 109606 coronin, actin-binding protein, 1A 2. 33 3. 38 449092 U91641 alpha2, 8-sialyltransferase 2. 32 3. 53 425367 BE271188 Hs. 155975 protein tyrosine phosphatase, receptor t 2. 32 7. 02 418117 AI922013 Hs. 83496 linker for activation of T cells 2. 30 3. 56 425795 AJ000479 Hs. 159543 EDG-6 (endothelial differentiation, G-p 2. 26 3. 42 428111 S76617 Hs. 2243 B lymphoid tyrosine kinase 2. 25 3. 69 439981 A1348408 Hs. 124675 ESTs, WeaklysimilartoT14742hypotheU 2. 25 4. 05 425722 Api659076 Hs. 97031 hypothetical protein MGC13047 2. 25 3. 44 436648 R18656 ESTs 2. 24 3. 23 452250 BE618654 Hs. 28607 hypotheticalprotein A-211C6. 1 2. 23 3. 08 441715 Al929453 Hs. 342655 HomosapienscDNAFW13289fis, cloneOV 2. 23 3. 30 423397 NM 001838 Hs. 1652 chemokine (GCmo6i) receptor7 2. 22 3. 25 449626 AA774247 Hs. 301637 zinc finger protein 258 2. 21 3. 14

412975 T70956 Hs. 75106 cluster (complement lysis inhibitor, S 2. 18 3. 41 418739 AA310964 Hs. 88012 SHP2 interacting transmembrane adaptor 2. 15 3. 62 418185 AW958272 Hs. 347326 intercellularadhesionmolecule2 (ICAM 2. 09 5. 21 436420 AA443966 Hs. 31595 ESTs 2. 07 3. 81 418174 L20688 Hs. 83656 Rho GDP dissociation inhibitor (GDI) bet 2. 05 3. 14 420626 AF043722 Hs. 99491 RAS guanyl releasing protein 2 (calcium 2. 01 4. 42 428289 M26301 Hs. 2253 complement component 2 2. 00 3. 33 429683 AF148213 Hs. 211604 adisintegnn-UkeandmeWloprotease (2. 00 3. 75 421445 AA913059 Hs. 104433 Homo sapiens, done ! MAGE : 4054868, mRNA 1. 96 3. 68 450300 AL041440 Hs. 58210 ESTs, Highly similar to ITH4 HUMAN INTER 1. 91 4. 84 416445 AL043004 Hs. 79337 KIAA0135 protein 1. 91 3. 41 409817 BE295464 Hs. 56607 Williams-Beuensyndromechromosaneegi 1. 87 3. 53 416967 BE616731 Hs. 80645 interferon regulatory factor 1 1. 86 3. 55 437740 AA810265 Hs. 122915 ESTs 1. 86 3. 79 437938 AI950087 gb : wq05c02. x1 NCl_CGAP_Kd12 Homo sapien 1. 83 3. 42 425240 AA306495 Hs. 1869 phosphoglucomutase 1 1. 83 3. 75 406972 M32053 gb : Human H19 RNA gene, complete cds. 1. 80 4. 03 430378 Z29572 Hs. 2556 tumor necrosis factor receptor superfami 1. 78 3. 53 437470 AL390147 Hs. 134742 hypothetical protein DKFZp547D065 1. 78 3. 39 416350 AF188625 Hs. 189507 phospholipase A2, group IID 1. 78 5. 48 417852 AJ250562 Hs. 82749 transmembrane 4 superfamily member 2 1. 78 4. 88 414682 AL021154 Hs. 76884 inhibitor of DNA binding 3, dominant neg 1. 77 5. 79 444090 S69115 Hs. 10306 natural killer cell group 7 sequence 1. 74 3. 41 427278 AL031428 Hs. 174174 KIAA0601 protein 1. 74 3. 80 418618 U66097 Hs. 86724 GTP cyclohydrolase 1 (dopa-responsive dy 1. 73 4. 21 420397 NM 007018 Hs. 97437 centrosomat protein 1 t. 73 3. 21 418678 NM 001327 Hs. 167379 cancerites6s antigen (NY-ESO-1) 1. 73 3. 77 459245 BE242623 Hs. 31939 manicfringe (Drosophila) homolog 1. 72 3. 12 425356 BE244879 Hs. 155939 inositol polyphosphate-Sphosphatae, 14 1. 71 3. 55 423984 AF163825 Hs. 136713 pre-B lymphocyte gene 3 1. 70 7. 70 422355 AW403724 Hs. 300697 coagulation factor VII (serum prothrombi 1. 70 3. 10 451579 AW607731 Hs. 26670 HumanPACcloneRP3-515N1from22q11. 2q 1. 68 4. 19 451287 AK002158 Hs. 26194 likely homolog of mouse immunity-associa 1. 68 5. 76 416819 U77735 Hs. 80205 pim-2 onco9ene 1. 67 3. 17 409896 AW205479 Hs. 279780 NY-REN-18 antigen 1. 67 3. 74 447532 AK000614 Hs. 18791 hypothetical protein FU20607 1. 66 3. 62 426666 AW500131 Hs. 171763 CD22 antigen 1. 65 4. 67 412265 AA101325 Hs. 86154 hypothetical protein FLJ12457 1. 65 3. 43 416971 R34657 Hs. 80658 uncoupling protein 2 (mitochondrial, pro 1. 64 3. 66 430449 AA352723 Hs. 241471 RNB6 1. 62 3. 09 424661 M29551 Hs. 151531 protein phosphatase 3 (formerly 2B), cat 1. 61 3. 37 453027 Api879341 Hs. 539 ribosomal protein S29 1. 61 11. 60 410068 Al633888 Hs. 58435 FYN-binding protein (FYB-120/130) 1. 60 3. 28 440446 NM013385 Hs. 7189 plecksttin homology, Sec7 and coiledlca 1. 59 3. 14 453657 W23237 Hs. 296162 AD037 protein 1. 59 3. 12 418102 R58958 Hs. 26608 hypothetical protein MGC15880 1. 58 3. 55 424614 X54486 Hs. 151242 serine (or cysteine) proteinase inhibito 1. 58 3. 07 406791 Al220684 Hs. 347939 hemoglobin, alpha 2 1. 55 5. 06 421703 AI936513 Hs. 1416 Fc fragment of IgE, low affinity 11, rec 1. 53 3. 59 421859 AA356620 Hs. 108947 KIAA0050 gene product 1. 52 3. 41 416783 AA206186 Hs. 79889 monocyte to macrophage differen6ation-a 1. 52 3. 28 456086 AL161999 Hs. 77324 eukaryotictransbtiontennination facto 1. 47 3. 34 425783 A1026740 Hs. 1948 ribosomal protein S21 1. 46 4. 95 407682 AL035858 Hs. 3807 FXYD domain-containing ion transport reg 1. 46 3. 48 409169 F00991 Hs. 50889 (clone PWHLC2-24) myosin light chain 2 1. 45 3. 25 435624 AF218942 Hs. 24889 formin 2 1. 45 3. 11 413969 X14034 Hs. 75648 phospholipase C, gamma 2 (phosphatidylin 1. 45 3. 33 426530 U24578 Hs. 278625 complement component 4A 1. 44 4. 27 425928 S55736 Hs. 238852 ESTs, Weakly similar to hypothetical pro 1. 44 3. 65 418219 AA731836 Hs. 137319 ESTs 1. 43 4. 01 429071 AW794126 Hs. 195453 ribosome protein S27 (metallopansfimuli 1. 41 4. 23 418473 AA243335 Hs. 309943 nuclear body protein Sp140 1. 41 3. 29 423766 AA303799 Hs. 300141 ribosomal protein L39 1. 40 3. 22 430150 L05148 Hs. 234569 zeta-chain (TCR) associated protein kina 1. 39 3. 29 416370 N90470 Hs. 203697 CD38 antigen (p45) 1. 36 3. 08 406758 AA552326 Hs. 77039 ATP synthase, H transporting, mitochondr 1. 32 3. 29 448610 NM_W6157 Hs. 21602 net (chicken)-like 1 1. 31 3. 85 444674 BE562200 Hs. 244 amino-terminal enhancer of split 1. 30 3. 10 407694 U77594 Hs. 37682 retinoic acid receptor responder (tazaro 1. 30 3. 91 427349 AA360154 Hs. 177415 Finkel-Biskis-Reilly murine sarcoma viru 1. 28 3. 59 419032 W81330 Hs. 99877 ESTs, Highly similar to JAK3B IH. sapiens 1. 28 3. 21 436553 AW407157 Hs. 8997 immunoglobulin lambda locus 1. 27 4. 00 415138 C18356 Hs. 295944 tissue factor pathway inhibitor 2 1. 24 3. 25 406623 X69392 ribosoma) protein L26 1. 24 3. 31 437895 A8014568 Hs. 5898 KIAA0668 protein 1. 21 3. 33 421143 AB024536 Hs. 102171 immunoglobulin superfamily containing le 1. 18 3. 35 TABLE 53B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession

441623 3362_1 BC022413 BE395396 BF754175 AA506621 BE706665 8E706678 AA723159 BE153169 BE706729 BE706558 BE153312 BE706706 AW371853 AW371849 BE153241 BC017410Al337912Al090244AW090300 BE219837 Al623661 BE501576 BE501734Al742232Al023964 Al458424M975373 AI288904 AI984583 AA890325 N32562 AI358102 AW241694 A1038448 A1672071 A1018389 AA576391 AA977874 AWi89392 W37448 AA612894 Api277548 H89551 Al699774 H89365 AA315805 AW579186 BC014584 BC014581 AW780125A1672414 BE328145 AW600919 BF031306 AW172758 BE708322AA345675 BE875779 H28241 H25318 BF540913 BG179688 BF110202 AA528775 W37573 BE041644 AW366504 8M129522 BM129822 Al122760 BE718200 AW887496 AA149420 BE706307 BE539395 BE748765 Al373653 R75904 BF979185 BF691393 BG495595 Bl094458 BE706702 BG496559 BF248373 BG494800 416373 3442_1 AK056582 AW755252 AL596757 BF827376 BF827373 BF827375 BF827369 BF826900 F01252 BC022888 BI850312 AA195845 BF825671 BF574821 Z21696 F32854 AA211780 F21569 AI288453 AI803678 AA180309 A1074627 AA192950 AA661688 F36698 F32290 F28773 F22692 AA424993 AW340328 AA192247 BF672229 BF575143 BF673106 BF693623 433470 6624_1 X75684AL573167 Al445461 Al453743 Al983655 Al564644 M977180AI694111 Al591353 AW071625AI678712 Al720939 Ai927769 BE439796 A1963432 AA292956 AW192593 A1865838 A1696905 A1424384 A1161312 A1911921 A1597801 B1494959 A1240988 A1492554 AW262737 BE044033 AW008570 AW629505 B) 494958 AA088439 AA706057 BF222820 BF593608 BE501957 AA524526 BE044134 AW572531 AW015724 BE349186 AA043217 BE219784 Al799814 M129575 Al671727 Al470033 BE646195 AW779725 AA903050 AA147228 AA404570 Al075878 W38161 A1972739 AW673152M723200 C06123 BF057147 AA627686 AA157944 AI990245 AA662517 T32487 A1800106 A1333170 A1859160 W45410 A1990827 AW275048 AA182640 AA478328 AI298935 AWO&5158 AW471421 AW103470 AW300456 AW191997 AI823466 AA962397 AA136658 AI251817 AW339104 AA724739 AA411100 AA191349 AA757735 AA037696 AI769516 AW772283 AA010631 AI692846 A1061065 H80983 R79933 A1950693 Al245632AI349390 M148284 Al798502M487893 Al621320 AW194272 C06365 M953883 BE858936 Ai918523 Al872628 M927217 Ai453453 AI189366 AW338678 AI261359 AI500576 BF477735 A1032569 AI972899 AI985583 Z28771 AI363829 AI693030 AA603586 BE773488 AW339301 BE773489 BE773462 BE773495 Api650338 BE773499 Al745717 BE811475 BE811470 BE811464 BE811418 BE811415 BE811400 BE811398 BE811388 BE811352 BE773501 BE773494 BE773486 BE773474 BE773473 BE773470 BE773461 BE811350 BE811337 BF593847 BG055071 AW675302 BF003068 AA719173 BE811348 A1582462 A1686240 BE773500 A1244845 A1565439 A1918453 A1472527 A1446740 AA035576 AA191414 AW674145 C05782 At589264 D57558 Al468237 AIU2033 M989662 R21752 BF002457 AA988297 AL574095 AL576200 AL571074 AL574525 AL578810 BG498381 Al928364 BE879732 AA479834 AA479712 C1773Z BM091258 BF843901 AW820230 Cl7476 BE327120 AA129574 AA136645 BF843900 AW806193 AA502832 AA649494 AL568520 AL547960 BE706937 BE811360 BE773498 BE811401 BE773484 BE811437 BE811380 BE811399 8F997171 BF757734 BE926037 Al377596 C06111 AW088968 BE811404 8E811472 AI865912 AI925607 AI871950 A1093510 BE905927 BE811435 AA191387 AW772000 BE81 1453 BE614379 BF844522 Bl044896 Al744233 AW984527 C17504 BF843883 Al248307 BE773483 Al567995 W60075 BF941183 Api738844 BE811458 BE773481 A1262930 AA948565 BE706942 BE156360 T65026 AW242958 AW197954 BE905184 AA722206 Al344943 Al348877 Al334860 BE621857 BE156280 AA454099 AA037722 BF843897 AW806183 AA043216. BG482896 AA182734 AA877242 AW372926 H27252 R38114 BF851858 BE156214 AA190427 T91762 AA035067 AA837326 T10930 BF906587 Bol755027 BG506731 BC008442 BC010166 AL550134 AL553096 AL548700 AL550751 AL547978 AL545286 AL540643 AU 118627 AL601379 B1259821 BG741786 Bi868522 AU 135866 81552770 BI259210 BI256520 81255569 BG485098 Bol258228 BG498501 BM044512 AU133984 AL556586 BE745111 81222633 AU133917 BG288151 B1260715 B1550550 BG500773 81551761 BG707601 Bol818593 BF691383 BG721129 BG541578 BE906666 BG751098 Bl224135 BG400746 BG478065 BE790436 AW080238 AU137549 BG429896 BE392486 AW961686 BG721056 BE908365 BE546656 BG541235 AW583735 BG528290 Bol260895 AW651691 BM048974 BM043805 BG142185 AA315188 AI446615 C06300 BG497644 AA088544 A1815987 BG528631 BE619182 AW239185 AW062910 AW062902 AA347236 F 11933 AA488005 AA301631 AA376800 D56120 AA343532 AA308636 F00242 AA376086 AA316968 AA343799 Bol870221 BE910282 BG538748 AW960564 AV732879 D16854 AA192519 BF922148 AA216013 BG624091 BE544387 BG507008 AW176446 BF790033 BE088925 BE088854 AA921353 R21800 AA011222 T97525 409245 3199_2 AF030234 BC017465 BG008526 AW505550 BM460141 N47324 AA361037 AA321632 N45606 AV752798 AV657116 AA296632 AU137857 AW467027 AI742080 AI624350 H58206 AA478518 AW439997 AW393555 AW393523 A1559753 A1808732 R66856 H01374 BI257369 81259830 AW960845 BM466252 AW956813 BE768647 AV658853 BM055248 BF372070 BF372055 BF372061 AA347852 AA905863 BG505078 AV654024 BF093291 AW021929 H22650 AA459715 BG496341 BE697763 Bl254209 BG499543 H42946 Bl059780 Bl086741 H87896 H87599 BF691752 BE768511 BG940948 W37195 BF372041 BE883796 BF372082 BF367329 BF909744 AW966003 AV714014 BI492868 81495144 AA921845 AI693426 AI652147 Al435449 N47325 Al434429 M573137 Al183429 Al829962 Al332526 BF513937 Al189561 Al221962 Al378034 AW118897 AW665247 AW340077 N41605 AA478519 AA463875 Al858260 M463379AI292305 BE045947 AA971089 Api125820 BG940947 A1080245 AA884954 AI125702 AI382934 M931835 Al358631 AW439905 A1027833 A1399648 A1014533 AA347851 AA738261 N67374 N69081 AI768667 AA948472 A1819214 AA293133 AI186725 AA889214 AI222635 BI495143 N29605 N48812 AA769041 AI492769 D56771 AA095911 BE222062 D56772 AW372265 BM054985 D12465 BG534562 AW003511 H87486 H42880 AW190293 BF594697 BF377611 H22043 Bl255749 Bl492848 H16217 H21980 H22651 H88179 H87354 H44052 H25165 H44128 417141 9517_1 Ai391712 U22662 NM 005693 AW166878 BF339795 Al970974 Al521157 Al336082 AW339789 Api288682 BF477594 BF477593 Al703008 Al290961 A1049684 AW770753 Al208561 Al699406 F33996 AA630563 AI985346 AI927058 AA533982 AW204589 Api206938 AW590068 Al 263769 M99 1550 Al192005 AL558946 AL524337 AL516239 AL580848 AL580658 Al719135 AW026500 Al698217 Al872977 Ai670983 Al654870M493407 M548525 Al016420 M843563 W15576 H61726 AA913245 BF438146 AL524338 B1762380 AU136488 Bl759892 AV655930 T78977 81524075 BE538944 425231 235504 1 AA527161 BG211784 AA527065 AA505489 AW512550 419631 27U_1 BC022323AF204171 NM022361 BM264431 BE670789AW188117 Al025298M861832 H84897 Al382294M662874AW993380 BE813742 H84368 Api188074 N20482 H84369 426969 12113-1 M59287 A1936504 A1694705 A1679216 A1679235 BFI 10184 AW51 8110 A1679811 AW054981 BE465531 BE327409 AW339105 81714787 AI871568 AW129115 AU145080 Al223299 AW129986 M780771 BG654629 AU144657 BF437422 Al478374 M492513 AU157562 Al826962 AU145528 AI951093 AW513819 AA042856 AA725690 AA733176 A1028702 AI251890 AI811729 AW975208 AW339589 AIt47868 AU157862 AA629327 BF476670 BE464796 AW510511 AA399098 AA398210 AI291998 AI160296 AU158075 N34811 BE326407 AI270552 AA496923 AA508002 AI270284 AI139504 BF437009 Al354626 Al936336 M287250 M491855 BF445818 AA688026 AA284510 AW151564 AA412072 AA709241 H89332 BF445769 BF989466 BF989472 AA631105 A ! 129915 W96362 AA515277 AA541513 L29222 AV758119 D82109 AL040956 BE244413 AV645640 BE246321 BE246314 D82116 AL036176 AA331779 AU100106 BE243857 AU076865 AW972327 AA497087 AI687039 AW072798 Api174455 AU156788 AA044401 AA046086 BE244986 Al634456 BE242945 BE242089 AU156034 BE244982 AL567955 81005141 AA040426 AW630506 BF155668 AU118544 BG573573 W96436 AA373395 BE710347AL564154 Al708332M729530 N92729AI573015 T29655 H89333 H85847 A1886473 AW189980 H02905 A1811986 AU157753 W86829 AA020844 AU158204 AA057356 AA283466 AA405504 AA017027 W94754 AA226498 W72391 H66461 C00442 H01925 Bol912232 406678 kO U77534 U77537 449092 44061 AK056270 AV706896 Ai692935 AI681140 AW162481 AW087114 AW157019 AI689795 AW251085 AW206911 BF438207 AW134945 BE041668 BF111425 U91641 NM 013305 BF968902 U55966 AU130750 BE174853 Api929731 AW161524 R43753 BE779688 436648 52977_1 AJW2788 AL118666AI381600 BE672862 AWSW520 BF223709 AW593740 AA262174 AA810597 AA810596 AA810595 F09382 BF976590 AW968002 AA262288 BF931698 AW968014 R18656 BM459356 AW794189 BF954184 Z42558 BF891641 BF963380 Z45874 F05187 X93079 BF742651 BF742649 R51324 080031 Bol457883 F06613 Z43128 F12243 BF950830 H19040 BF950829 F06439 R14947 F06702 R61037 R52173 R14953 R12174 R13610 H10426 R11851 T65264 R18737 437938 66997 1 U71456 AA482911 W78802 AW856538 BF737212 N36809 N35320 AA282915 AW505512 Api653832 W87891 Al961530 T85904 H59397 R97278 W01059 A ! 820532 T82391 Api820501 T63226 R66056 R67840 AW961101 AA337499 W37181 AA180009 AW205862 AA988777 AA856975 BF172457 BG751124 Al741346AI950344 Al689062 Al872193 AW102898 AW173586 Al763273 Al890387 AW150329 Al762688 M488892 Al356394 Al539642 AA642789 A1950087 BF589902 N70208 AA283144 AA488964 H60052 R97040 BF886630 AW967677 AW971573 AW967671 A1308119 AA251875 AA908598 AI819225 AI564269 AA90874t AA293273 AA969759 AW276905 AA044209 H83488 T92487 406623 kO X69392 T24055 TABLE 53C : Pkey : Unique number corresponding to an Eos probeset

Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 405545 1054740 Plus 118677-118807, 119091-119296. 121626-12182 401566 8469090 Minus 96277-96420, 96979-97160 405547 1054740 Plus 124361-124520, 124914-125050 TABLE 54A : ABOUT 161 GENES UPREGULATED IN PRIMARY MELANOMAS FROM TUMORS THAT LATER METASTASIZED RELATIVE TO PRIMARY MELANOMAS THAT DID NOT METASTASIZE LATER Table 54A lists about 161 genes upregulated in primary melanomas from tumors that later metastasized relative to primary melanomas that did not metastasize later. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title RI : 90th percen6le of Als for primary melanomas that later metastasized divided by the 90th percentiie of Als for primary melanomas that did not metastasize later R2 : 90th percen6le of Als for primary melanomas that later metastasized divided by the 90th percentage of Als for primary melanoma that did not metastasize later, where the 15th percent of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 448966 AW372914 Hs. 86149 phosphoinositol 3-phosphate-binding prot 7. 15 3. 41 413916 N49813 Hs. 75615 apolipopnotein C ll 5. 93 6. 55 414807 A1738616 Hs. 77348 hydroxyprostaglandin dehydrogenase 1S (N 5. 64 2. 98 415668 AW957684 Hs. 306814 hypothetical protein FLJ21889 5. 03 4. 56 440274 R24595 Hs. 7122 scrapie responsive protein 1 4. 98 4. 83 417542 J04129 Hs. 82269 pnDgestagen-asociated endomeiriå prote 4. 96 7. 07 427882 AA640987 Hs. 193767 ESTs 4. 68 4. 68 452744 A1267652 Hs. 246107 Homo sapiens mRNA ; cDNA DKFZp434E082 (fr 4. 29 3. 06 407907 AI752235 Hs. 41270 procollagen-lysine, 2-oxoglutarate 5-dio 3. 94 3. 86 424410 W79027 Hs. 271762 ESTs 3. 67 3. 19 429083 Y09397 Hs. 227817 BCL2-related protein A1 3. 46 2. 49 407951 W77762 Hs. 79015 antigen identified by monoclonalantibod 3. 31 3. 06 428330 L22524 Hs. 2256 matrix metatioproteinase 7 (matniysin. 3. 27 2. 12 440099 AL080058 Hs. 6909 DKFZP564G202 protein 3. 22 2. 69 428001 H97428 Hs. 219907 ESTs, Moderately similar to Transforming 3. 20 1. 85 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 3. 18 4. 61 442432 BE093589 Hs. 38178 hypotheticalprotein FU23468 3. 13 2. 11 430643 AW970065 Hs. 287425 MEGF10 protein 3. 10 3. 31 412262 W26406 seven in absenta (Drosophila) homolog 1 3. 06 3. 94 438328 A1492261 Hs. 32450 ESTs 3. 05 3. 09 409760 AA302840 gb : EST10534 Adipose tissue, white) Homo 3. 01 2. 65 453912 AL121031 SWIISNF related, matrix associated, x6 2. 94 1. 86 416426 AA180256 Hs. 210473 Homo sapiens cDNA FU 14872 fis, clone PL 2. 91 3. 70 407744 AB020629 Hs. 38095 ATP-binding cassette, sub-family A (ABC1 2. 88 2. 53 453935 A1633770 Hs. 42572 ESTs 2. 88 2. 00 452689 F33868 Hs. 284176 transfer 2. 84 6. 47 449550 AA353125 Hs. 184721 ESTs 2. 83 4. 74 409417 AA156247 Hs. 104879 serine (or cysteine) proteinase inhibito 2. 82 2. 43 438898 A1819863 Hs. 106243 ESTs 2. 81 2. 08 430191 A1149880 Hs. 188809 ESTs 2. 80 2. 69 408418 AW963897 Hs. 44743 KIAA1435 protein 2. 79 1. 75 450157 AW961576 Hs. 60178 ESTs 2. 77 3. 40 420380 AA640891 Hs. 102406 ESTs 2. 77 4. 28 443172 AW662964 Hs. 199061 p300/CBP-associated factor 2. 75 2. 88 456629 AW891965 histone deacetylase 3 2. 72 2. 24 407857 A1928445 Hs. 92254 synaptotagmin-like 2 2. 72 1. 93 421097 Ai280112 Hs. 125232 Homo sapiens CDNA FU 13266 fis, clone OV 2. 68 2. 59 436280 A1690734 Homo sapiens cDNA : FLJ22562 fis, clone H 2. 67 2. 79 407550 Y10515 gb : H. sapiens mRNA for CD58 T7 protein. 2. 65 1. 98 427871 AW992405 Hs. 59622 Homo sapiens, clone IMAGE : 3507281, mRNA, 2. 64 1. 76 427899 AA829286 Hs. 332053 serum amyloid At 2. 59 3. 01 442793 A1017798 ESTs. WeaklysimilartoTI47 HUMANCARGO 2. 58 1. 60 446619 AU076643 Hs. 313 secreted phosphopmtein 1 (osteoponfin, 2. 57 1. 91 444381 BE387335 Hs. 283713 ESTs. Weakly similar to S64054 hypothefi 2. 57 2. 13 458247 R14439 Hs. 209194 ESTs 2. 56 2. 61 451668 Z43948 Hs. 326444 cartilage acidic protein 1 2. 52 2. 74 433980 AA137152 Hs. 286049 phosphoserine aminotransferase 2. 51 1. 88 412719 AW016610 Hs. 816 ESTs 2. 50 1. 68 441789 D52059 Hs. 7972 KIAA0871 protein 2. 50 3. 11 405885 Target Exon 2. 50 3. 15 453464 Al884911 Hs. 32989 receptor (calcitonin) activity modifying 2. 48 3. 33 417821 BE245149 Hs. 82643 protein tyrosine kinase 9 2. 48 1. 66 450202 AW969756 Hs. 34145 ESTs, Weakly similar to B49647 GTP-bindi 2. 47 2. 79 436825 AW341123 Hs. 120275 ESTs 2. 47 2. 55 424762 AL119442 Hs. 183684 eukaryotic translation initiation factor 2. 42 2. 28 432426 AW973152 Hs. 31050 ESTs 2. 42 1. 76 409095 AW337272 Hs. 293656 ESTs, Moderately similar to S72481 proba 2. 41 2. 41 403752 NM002753' : Homo sapiens mitogen-activate 2. 41 2. 87

404489 Target Exon 2. 39 1. 97 411690 AA669253 RNA, U2 small nudear 2. 37 2. 54 439195 H89360 gb : yw28dO8. s1 Morion Fetal Cochlea Homo 2. 37 2. 27 453582 AW854339 Hs. 33476 hypothetical protein FLJ11937 2. 36 2. 81 438461 AW075485 Hs. 286049 phosphoserineaminotransferase 2. 35 2. 91 432878 BE386490 Hs. 279663 Pidn 2. 35 2. 28 416647 BE297139 Hs. 79411 replication protein A2 (32kD) 2. 33 1. 97 428666 AL080190 Hs. 189242 Homo sapiens mRNA : cDNA DKFZp434A202 (fr 2. 32 2. 92 413645 AA130992 gb : zo15e02. s1Stratagenecolon (937204) 2. 31 2. 63 421282 AA286914 Hs. 40782 ESTs 2. 31 1. 85 434418 AF134707 Hs. 278679 a disintegrin and metalloproteinase doma 2. 31 2. 21 413204 BE071603 gb : QV3-BT0510-161299-032-fO3 BT0510 Homo 2. 31 1. 49 449720 AA311152 Hs. 288708 hypotheticaf protein FLJ21562 2. 30 1. 78 451838 AW005866 Hs. 193969 ESTs 2. 28 2. 05 410943 AW968322 Hs. 11156 S6 low molecular mass ubiquinone-binding pr 2. 28 2. 39 459711 BE386801 Hs. 21858 trinucleo6derepeatcontaining3 2. 27 2. 39 429489 AF008203 Hs. 204039 aristaless-like homeobox 3 2. 26 1. 97 429493 AL134708 Hs. 145998 ESTs 2. 26 2. 77 422283 AW411307 Hs. 114311 CDC45 (cell division cycle 45, S. cerevis 2. 26 1. 78 441989 AA306207 Hs. 286241 protein kinase, cAMP-dependent. regulato 2. 26 1. 84 419352 A1675008 Hs. 199493 ESTs 2. 25 1. 47 427393 AB029018 Hs. 177635 KIAA1095 protein 2. 25 1. 83 418522 AA605038 Hs. 7149 Homo sapiens cDNA : FLJ21950 fis, clone H 2. 24 2. 42 433468 AA832055 Hs. 172843 ESTs, Weakly similar to ALU1 HUMAN ALU S 2. 24 1. 76 452782 AA028166 Hs. 17733 ESTs 2. 24 2. 34 443910 AW051711 Hs. 132440 ESTs 2. 24 1. 79 408832 AW085690 Hs. 63428 ESTs, Weakly similar to Z195_HUMAN ZINC 2. 22 1. 52 407283 T51008 gb : yb55e08. sl Stratagene ovary (937217) 2. 22 1. 31 437376 AA749400 Hs. 257890 ESTs 2. 22 2. 44 450712 Api732130 Hs. 270496 ESTs, WeaklysimilartoALUB_HUMAN ! ! ! ! 2. 22 1. 62 421362 AK000050 Hs. 103853 hypothetical protein FU20043 2. 22 2. 36 445183 AB007877 Hs. 12385 KIAA0417 gene product 2. 20 1. 84 438501 Z44110 Hs. 86149 phosphoinositol 3-phosphate-binding prot 2. 20 1. 76 432882 NM 013257 Hs. 279696 serum/glucocorticoid regulated kinase-li 2. 19 1. 59 414900 AW452420 Hs. 248678 ESTs 2. 18 1. 89 427704 AW971063 Hs. 292882 ESTs 2. 17 1. 86 404942 splicing factor, arginine/serine-rich 9 2. 17 1. 86 448019 AW947164 Hs. 195641 ESTs, Moderately similar to 138022 hypot 2. 17 1. 64 459254 AA694386 Hs. 290914 ESTs 2. 16 1. 61 418965 AID02238 Hs. 11482 splicing factor, arginine/serine-rich 11 2. 16 1. 79 443357 AW016773 low molecular mass ubiquinone-binding pr 2. 16 2. 32 412432 AA126311 Hs. 9879 ESTs 2. 15 2. 73 449567 A1990790 Hs. 188614 ESTs 2. 08 2. 85 433179 AW362945 Hs. 162459 ESTs 2. 07 4. 77 408243 Y00787 Hs. 624 intedeuvin 8 2. 05 3. 12 435294 T84084 Hs. 196008 HomosapienscDNAFLi11723fis, cloneHE 1. 97 2. 89 449656 AA002008 Hs. 188633 ESTs 1. 94 3. 60 412649 NMp2206 Hs. 74369 integrin, alpha 7 1. 93 2. 76 445162 ABO1113t Hs. 12376 piccoto (presynapticcytomaNxprotein) 1. 93 2. 66 419356 Api656166 Hs. 7331 hypothetical protein FLJ22316 1. 92 3. 39 424263 M77640 Hs. 1757 L1cell adhesion molecule (hydrocephalus 1. 89 3. 10 414694 NM 015362 Hs. 76907 HSPC002 protein 1. 88 4. 25 415825 Y18024 Hs. 78877 inositol 1, 4, Strisphosphate 3kinase B 1. 87 2. 66 409105 AW467539 Hs. 255877 ESTs 1. 87 2. 96 444784 D12485 Hs. 11951 ectonucleo6de pyrophosphatase/phosphodi 1. 85 2. 80 404149 C6002509-: gil5031885lenNP_W5568. 1l li 1. 84 2. 93 406387 Target Exon 1. 82 2. 96 420871 AA702972 Hs. 65300 ESTs 1. 76 3. 12 455797 BE091833 gb : lL2-BT0731-260400*076 F04 BT0731 Hamo 1. 75 3. 12 418751 BE389014 phosphoinositide-3-kinase, regulatory su 1. 70 3. 20 412347 AW970026 Hs. 73818 ubiquinoi-cytochnzmecreduclæehingep 1. 67 3. 65 413211 AW967107 Hs. 109274 hypothetical protein MGC4365 1. 66 2. 89 459317 BRCAlb Eos Control 1. 61 7. 34 425525 AA358883 Hs. 23871 ESTs 1. 59 2. 67 436823 AW749865 Hs. 117077 ESTs, Weaklysimilartol38022hypolhe6 1. 56 2. 76 433669 AL047879 Hs. 194251 ESTs, Weakly similar to ALU2_HUMAN ALU S 1. 55 2. 76 424389 AA339786 lymphocyte-specific protein 1 1. 53 2. 95 426672 AW270555 Hs. 171774 hypothetical protein 1. 51 3. 39 415977 AL037622 Hs. 78935 methionine aminopeptidase ; eIF-2-associa 1. 47 2. 65 404780 Target Exon 1. 43 2. 77 436476 AA326108, Hs. 33829 bHLH protein DEC2 1. 41 3. 04 428284 AA535762 Hs. 183435 Nom004545 : Homo sapiens NADH dehydrogenas 1. 38 2. 94 448571 AA486794 Hs. 66915 ESTs, Weakly similar to 16. 7Kd protein 1. 37 2. 80 428156 BE269388 Hs. 182698 mitochondrial ribosomal protein L20 1. 36 3. 29 447752 M73700 Hs. 105938 taetotransfemn 1. 35 2. 70 447455 H38335 Hs. 6750 Homo sapiens mRNA for FLJ00058 protein, 1. 35 3. 03 453281 W46280 Hs. 55940 ESTs. Weakly similar to A25704 synapsin 1. 34 2. 69 413142 M81740 Hs. 75212 omithine decarboxylase 1 1. 33 2. 96 407194 AA621644 gb : a54aO1. si Soares_total fetus_Nb2HF8_ 1. 32 2. 70 444107 T46839 Hs. 10319 UDP glycosyltransferase 2 family, polype 1. 26 3. 27 406797 A1432224 ribosome ! protein L6 1. 26 2. 72 406711 N25514 Hs. 77385 myosin, lightpolypep6de6, akái, smo 1. 25 7. 10 414608 BE396215 Hs. 76572 ATP synthase. H transporting, mitochondr 1. 24 2. 72

401846 NM000988' : Homo sapiens ribosomatprotei 1. 24 2. 82 432982 AA531058 Hs. 182248 truncated calcium binding protein 1. 23 3. 10 428578 BE391797 Hs. 343588 ribosome protein S12 1. 23 2. 74 400199 Eos Control 1. 21 3. 58 400079 Eos Control 1. 20 2. 99 412623 R28898 Hs. 74170 metallothionein I E (functional) 1. 19 2. 63 406713 U02629 Hs. 77385 myosin, light polypeptide 6, alkali, smo 1. 19 4. 15 406712 M31212 Hs. 77385 myosin, light polypeptide 6. alkali, smo 1. 18 4. 75 442492 AA528489 Hs. 234518 ribosome protein L23 1. 17 2. 74 431526 Y10129 Hs. 258742 myosin-binding protein C, cardiac 1. 17 3. 15 436398 H87136 Hs. 5174 ribosome protein S17 1. 16 3. 22 432205 Al806583 Hs. 125291 ESTs 1. 15 2. 76 406859 Api581134 Hs. 181357 lamininreceptor1 (6hD, nbosomaprot 1. 09 2. 66 401254 Target Exon 1. 00 3. 08 405752 Target Exon 1. 00 2. 87 445772 A1733941 Hs. 145493 ESTs, Weakly similar to ALU7-HUMAN ALU S 1. 00 2. 70 452916 AA642831 Hs. 31016 putative DNA binding protein 1. 00 2. 62 451411 AA017492 Hs. 135655 EST 1. 00 2. 64 415658 BE501921 Hs. 270471 ESTs 1. 00 2. 82 448610 NM_006157 Hs. 21602 nel (chickenFlike 1 1. 00 3. 30 TABLE 548 : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 412262 4362_1 AK056051 AI971258 AI681134 AU146134 AI803300 AA917325 AA923663 BF895068 A1304442 Al167464 A1284188 AA054272 AA829262 A1351910 T90930 At886230 U70056 AU119916 BF446537 BE503207 BE502849 Ai698102 M258553 AV718529 AV719917 BF724133 B ! 438668 A1804000 BE349103 Al912294 BE645117 AA227954 AA446520 AA879147 AA281770 AW136872 AA807907 AI435989 AI339626 AI383274 AA418512 BE771804 BF894509 AA455093 AI379061 Al150855 BF769906 R17298 AU138740 BF808607 BE674633 AV700132 AA227789 AA253099 AW975199 AA935418 T74315 F12666 AA022923 T89028 AA258606 W26406 BE838620 AV700706 AA101321 R41382 H 14479 AA253044 R54810 R42784 R44804 R41278 409760 865166 1 AA302840 T93016 T92950 AU 184997 AA077551 453912 32562_3 BM472224 B) 966849 B) 966735 AW973032 B1962894 B) 963048 AA548765 A ! 926504 AA041551 AW043754 A1086702 AW008105 AA974849 AW614893 AA553737 AA916996 AW262982 Api580991 BF726843 AV693312 W35325 AA039927 BG460936 AW388482 AW388420 BF374777 W01360 N94710 H87967 456629 207_22 AW891965 AW604749 BE080872 R15559 BE177623 AW883520 AW945343 Al246167 T07082 AW805679 W96278 AA135796 W32615 AW995418 AW801688 BE003837 AW801621 AW385721 AW385742 AW385714 AW604757 W87409 AW604738 AW385757 AW580796 AW801247 BE003239 BE003183 AA847112 AW580975 AW604760 AW385727 BE164590 BE003090 AW362791 AW604759 AW866589 AW604758 N44337 A1378548 AW890438 AA077172 A) 288683AA229639 AA091945 AW945454 AA063629 AA702504 AW861938 AW894816 AW580841 AA094372 T06399 AW885686 BE244086 BE005035 AW861913 AA551773 AW858460 AW370926 AW754352 AW889695 AW384408 A1907428 BED67491 AW861939 AA248197 AW381373 AW177325 AW806879 AA935217 BE067498 BE083742 BE067470AW894935 BE082529 Al248811 BE179917 BE002200 AW607506 AW392889 AW894560 AW381360 Api904206 AW863533 C00609 AW381372 BE082530 AW898120 BE075323 AW392799 AW601420 Al695314 BE083790 AW858568 AW945550 BE177153 AW970506 BE350419 A1906919 AW360794 A1906917 AW885979 AW794240 AW945566 Al688683 Al688694 AW009660 AW601421 AW360793 BE066524 BE083901 AW369847 AW381871 AW935435 AW664582 AW877775 AW838449 BE180466 AW858501 BE180464 A1371163 AA778231 Al174991 BE011720AW877776 AW8778W AW877795 T19900 AW866365 AW898099 BE011715 BEt67842 BE011718 BE011724 AW363639 AW878658 AW878662 AW894887 BE082356 AW389211 AW804286 AW610312 Al904717 AW610318 AW996909 AW610296 AW901923 AW880003 Api762171 AW062582 AW368713 AW062593 AW176663 AW842064 AW842089 AW842095 At243049 AW902074 AW062592 AW176664 AW751692 BE087703 A1907439 BE009686 BE172115 BE077030 AW608556 AW835577 Api909628 BE077029 AW176241 BE077552 BE160370 BE160288 AW835656 AW606765 AW606770 AW835678 AW606758 AW606778 At907484 BE172821 AW606768 AW999517 AW844165 BE171738 AW751683 AW610493 BE177484 BE177487 M090510 AW844117 BE173367 AW999878 Al124870 BE163472 AW841823 AW379762 AW893297 Al290296 BE089132 M610287 AW176676 AW607622 BE172639 AW893232 AA329629 BE089008 BE178350 BE178214 BE063291 AW820236 AW999653 BE089486 BE173126 BE171775 BE185787 AA558280 A1174840 AW999112 BE218391 BE172734 BE178021 GE172738 BE173324 AW603494 AL036722 R38i92 R60905 H53721 H41052 AL037917 R37795 AW998972 AA767189 AW044272 H50689 AA768399 AA767764 A1087888 H44202 BE222792 N90597 W81396 N90615 AI935353 BE501168 F10945 AW i18215 AI970480 At627641 AW236081 AA574090 A1627652 AI681913 AI759983 N69591 N69276 BE467722 AW392780 BE172467 H92861 A1524921 F02989 Z39328 F02705 F01414 T88678 AI215165 H87220 AW374781 436280 36296_1 AK026215 Al201248 BE671206 AA860436 AA730787 AA834507 D79304 D79806 AW961628 A1017068 BE044373 AA322458 AA987927 AA385869 Bol492783 AW021853 R79299 N73208 A1016622 N24609 AW192569 AA707819 AI69W34 R79189 Al535900 AW589301 AI128434 BE838011 BE837891 BF894555 H95408 442793 417820_2 BG741247 BG741022AI017798 Al953594 AW445065 Al245087 411690 53926_1 AK027091 BF514593 BF768430 Bl037830 BE175161 BGOW114 BG897171 AA745391 AA669569 AA669253 B1049453 BE304449 BG010136 BG830874 BF091358 BF762561 T56173 BC003629 BF091330 BE697323 BF091340 BE843330 AA744150 AA745471 W26276 B1037837 439195 21979_1 AF086037 H89360 H89546 413645 1234345 1 AA130992 AW969537 AA503835 413204 1494523-1 BE071616 BE071613 BE071603 BE071587 BE071607 BE071615 BE071636 443357 427117J AV715934 BG654600 A1052778 BG057892 AW01 6773 A1452937 AW085293 455797 1511159 1 BE091833 BE091874 BE091871 418751 21393_t BF690141 BE159368 AI937311 AU15125fi AW341542 AW274231 AW341609 AW450447 AA843698 AW 188066 AW007171 AW007027 A1075008 AL520351 AA608992AW151842AA622181 A1273454A1005661 AA205946AA677899AW473512AW296620AA872899A ! 094216A ! 025188AA256998 AI539154 AI500192 AI289493 A1040740 BE167841 AWi51374 BEt67754 BF036108 AA299181 N23237 T62967 W96060 AA574412 AW606697 W96059 R51303 R09158 R59113 T48473 T59023 AA122066 AW606643 R38386 R06567 424389 1059_4 BG190758 AW961118 W77994 AA339877 AW845121 AW845129 BG181820 BE716719 Al125483 Al161017 W73951 A1250771 AA912611 AA339786 BE838286 BE838282 BE716636 AA777158 W94063 BE716628 BE716625 BE838371 BF371044 BE716631 BE716402 406797 0_0 Al432224 AW276890 Al499346 AA937014 AA653573 AI318525 AI246219 AA961591 AI270640 TABLE 54C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons.

Pkey Ref Strand N-_posifon 405885 7677703 Minus 42574-42998 403752 7678857 Plus 33704-33828 404489 8113772 Plus 98183-98480 404942 7382153 Plus 92095-92252 404149 7534008 Plus 121831-121951, 124044-124150 406387 9256180 Plus 116229-116371, 117512-117651 404780 9887810 Minus 175708175871 401846 7712190 Minus 82775-82823, 82912-83022 401254 9796309 Plus 152209-152383 405752 9212305 Plus 91392-91528 TABLE 55A : ABOUT 201 GENES UPREGULATED IN PRIMARY MELANOMAS FROM TUMORS THAT DID NOT METASTASIZE RELATIVE TO PRIMARY MELANOMAS THAT LATER METASTASIZED Table 55A lists about 201 genes upregulated in primary melanomas from tumors that did not metastasize relative to primary melanomas that metastasized later. Genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al) a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number Genbank accession number UnigenelD : Unigene number Unigene Tide : Unigene gene bUe RI : 90th percentile of Als for primary melanomas that did not metastasize divided by the 90th percentage of Ais from primary melanomas that metastasized later R2 : 90th percenfile of Als for primary melanomas that did not metastasize divided by the 90th percentile of Als from primary melanomas that metastasized later, where the 1 5th pencen61e of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Tiüe R1 R2 413554 AA319146 Hs. 75426 secretogranin 11 (chromogranin C) 8. 08 5. 48 404854 Target Exon 5. 18 8. 18 406636 L12064 gb : Homo sapiens (clone WR4. 12VL) an6-th 4. 89 4. 95 433435 BE545277 Hs. 340959 Ts translation elongation factor, mitoch 4. 83 4. 86 408471 NM_012317 Hs. 45231 leucine zipper, down-regulated in cancer 4. 71 4. 70 433658 L03678 Hs. 156110 immunoglobulin kappa constant 4. 71 3. 85 412802 U41518 Hs. 74602 aquaporin 1 (channel-fortning integral pr 3. 98 4. 01 415801 R24219 Hs. 278443 FchragmentoflgG lowaifinibilb re 3. 92 3. 35 400417 X72475 Target 3. 83 2. 78 419870 AW403911 Hs. 266175 phosphoprotein associated with GEMs 3. 67 2. 29 409190 AU076536 Hs. 50984 sarcoma amplified sequence 3. 62 3. 68 408692 AL040127 Hs. 34074 dipeptidylpeptidase VI 3. 61 3. 89 423619 T48691 Hs. 249159 adrenergic, alpha2A-receptor 3. 56 3. 61 442117 AW664964 Hs. 128899 ESTs ; hypothetical protein for IMAGE : 447 3. 55 2. 85 445745 AB007924 Hs. 13245 KlM0455geneproduct 3. 38 2. 55 406663 U24683 immunoglobulin heavy constant mu 3. 34 6. 16 414522 AW518944 Hs. 76325 Immunoglobulin J chain 3. 32 2. 75 419235 AW470411 Hs. 288433 neurotrimin 3. 32 2. 74 441598 A1733219 Hs. 58262 ESTs 3. 31 3. 71 402294 Target Exon 3. 24 2. 35 402737 Target Exon 3. 22 2. 87 414135 NM004419 Hs. 2128 dual specificity phosphatase 5 3. 20 3. 04 410268 AA316181 Hs. 61635 six transmembrane epithelial antigen of 3. 18 2. 81 427335 AA448542 Hs. 251677 G antgen 7B 3. 17 4. 62 404995 ENSP00000251890' : Monocytic leukemia zinc 3. 13 2. 34 430540 AW245422 Homo sapiens cDNA : FLJ22105 fis, clone H 3. 12 2. 21 430015 AW768399 ESTs 3. 12 1. 93 414340 A1022656 Hs. 296272 ESTs 3. 09 2. 87 400072 Eos Control 3. 08 3. 16 422567 AF111178 Hs. 118407 glypican 6 3. 06 2. 73 401284 Target Exon 3. 04 2. 56 455839 BE145814 gb : MRO-HT0208-101299-202-a04 HT0208 Homo 3. 02 2. 76 454027 R40192 Hs. 21527 Human DNA sequence from clone GS1-115M3 3. 00 3. 15 437258 AL041243 Hs. 174104 ESTs 2. 99 2. 44 445612 N94126 Hs. 12969 hypothetical protein 2. 98 2. 40 417777 A1823763 Hs. 7055 ESTs Weakly similar to 178985 sednefth 2. 97 2. 13 437723 Al672731 Hs. 13256 ESTs 2. 95 2. 46 439668 Al091277 Hs. 302634 frizzled (Drosophila) homolog 8 2. 95 2. 77 424321 W74048 Hs. 1765 lymphocyte-specific protein tyrosine kin 2. 94 2. 68 424761 AA534528 Hs. 152944 ! ossofheterozygosity. 11. chromosomai 2. 92 3. 81 405757 Target Exon 2. 92 3. 00 406621 X57809 Hs. 8997 immunoglobulin lambdalocus 2. 92 6. 71 409060 Ai815867 Hs. 50130 necdin (mouse) homolog 2. 86 2. 16 431712 R26584 Hs. 267993 hypothetical protein FLJ10143 2. 82 2. 50 413441 A1929374 Hs. 75367 Src-like-adapter 2. 82 2. 48 452651 Al218918 Hs. 30209 KIAA0854 protein 2. 82 1. 13 422386 AF105374 Hs. 115830 heparan sulfate (glucosamine) 3-0-sulfot 2. 78 2. 77 439778 AL109729 Hs. 99364 putative transmembrane protein 2. 77 1. 92 434293 NM004445 Hs. 3796 EphB6 2. 75 2. 89 406642 AJ245210 gb : HomosapiensmRNAforimmunoglobulin 2. 70 2. 03 406638 M13861 gb : Human T-cell receptor active beta-cha 2. 69 2. 67 432331 W37862 Hs. 274368 MSTP032 protein 2. 68 3. 08 408989 AW361666 Hs. 49500 KIAA0746 protein 2. 68 2. 58 401731 NM_017990': HomosapienshypoUheUcalpro 2. 68 2. 53 401979 C17000767 : git1990770 ! embCAC19651. 1HA 2. 68 3. 42 415539 Al733881 Hs. 72472 BMP-R1B 2. 68 2. 51

425032 NM 001186 Hs. 154276 BTB and CNC homology 1, basic leucine zi 2. 67 2. 13 406837 R70292 Hs. 156110 immunoglobulin kappa constant 2. 66 3. 25 422550 BE297626 Hs. 296049 microfibrillar-associated protein 4 2. 66 2. 74 425100 AF051850 Hs. 154567 supervillin 2. 65 2. 80 452933 AW391423 Hs. 288555 Homo sapiens cDNA : FU22425 fis, clone H 2. 65 2. 63 439706 AW872527 Hs. 59761 ESTs, Weakly similar to DAP1 HUMAN DEATH 2. 64 1. 84 447232 AW499834 Hs. 327 intedeukin 10 receptor, alpha 2. 63 2. 63 425580 L11144 Hs. 1907 galanin 2. 62 2. 00 450680 AF131784 Hs. 25318 Homo sapiens clone 25194 mRNA sequence 2. 61 1. 80 412482 Al499930 Hs. 334885 mitochondrial GTP binding protein 2. 61 1. 82 433470 AW960564 transmembrane 4 superfamily member 1 2. 60 2. 44 419138 U48508 Hs. 89631 ryanodine receptor 1 (skeletal) 2. 60 2. 47 401112 NM 024997' : Homo sapiens hypothetical pro 2. 60 2. 58 411802 AA733204 nuclear transcription factor Y, gamma 2. 59 2. 32 407856 AA045281 Hs. 266175 phosphoprotein associated with GEMs 2. 59 1. 88 425209 AL049761 Hs. 155140 casein kinase 2, alpha t polypeptide 2. 58 2. 81 417165 R80137 Hs. 302738 Homo sapiens cDNA : FLJ21425 fis, clone C 2. 56 2. 10 442560 AA365042 Hs. 325531 ESTs, Weakly similar to 2004399A chromos 2. 55 3. 97 408491 A1088063 Hs. 7882 ESTs 2. 54 2. 74 420223 N27807 ribosomal protein L4 2. 54 2. 02 444467 A1150368 Hs. 143844 ESTs 2. 54 2. 59 436729 BE621807 transmembrane 4 superfamily member 1 2. 53 2. 29 449217 AA278536 Hs. 23262 ribonuclease, RNase A family, k6 2. 53 1. 80 453507 AF083217 Hs. 33085 WD repeat domain 3 2. 52 1. 99 420315 NM006299 Hs. 96448 zinc finger protein 193 2. 52 2. 50 443060 D78874 Hs. 8944 procollagen C-endopeptidase enhancer 2 2. 50 2. 35 453500 Al478427 Hs. 43125 esophageal cancer related gene 4 protein 2. 50 2. 44 402692 Target Exon 2. 50 1. 73 427792 M63928 Hs. 180841 tumor necrosis factor receptor superfami 2. 50 4. 55 440065 W03476 Hs. 266331 hypothetical protein MGC4595 2. 49 2. 95 420568 F09247 Hs. 247735 protocadherin alpha 10 2. 49 3. 55 444115 AW954585 Hs. 271920 ESTs, Weakly similar to Z195 HUMAN ZINC 2. 49 2. 52 404049 NM018937' : Homo sapiens protocadhenn be 2. 48 2. 67 417694 R09486 Hs. 193118 ESTs 2. 48 2. 09 420600 BE011657 Hs. 165695 ESTs, Weakly similar to unnamed protein 2. 48 2. 00 429922 Z97630 Hs. 226117 H1 hisionefamily, memberO 2. 47 2. 01 404752 NM024778 : Homo sapiens hypothetical prot 2. 47 3. 07 421429 NM014922 Hs. 104305 death effecta filament-forming Ced-4-li 2. 47 2. 46 436378 AJ227874 Hs. 99244 ESTs 2. 46 1. 88 429852 AB010445 Hs. 225948 small inducible cytokine subfamily A (Cy 2. 44 2. 98 431190 AL134172 Hs. 120852 ESTs 2. 44 2. 48 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 2. 44 2. 96 436608 AA628980 Hs. 192371 downsyndromecriScalegionpnoteinDS 2. 44 3. 16 445547 D86181 Hs. 273 galactosylceramidase (Krabbe disease) 2. 43 3. 33 443030 R68048 Hs. 9238 hypothetical protein FLJ23516 2. 43 2. 07 416908 AA333990 Hs. 80424 coagulation factor XIII, A1 polypeptide 2. 43 3. 36 406782 AA430373 gb : zw20f11. s1 Scares ovary tumor NbHOTH 2. 40 3. 38 407260 L09095 gb : Homo sapiens mRNA fragment. 2. 38 3. 78 419556 U29615 Hs. 91093 chitinasel (chitotriosidase) 2. 36 3. 56 431365 AA504080 Hs. 191958 immunoglobulin superfamily receptor tran 2. 34 2. 84 414555 N98569 Hs. 76422 phospholipase A2, group IIA (platelets, 2. 33 3. 21 436485 X59135 Hs. 156110 immunoglobulin kappa constant 2. 31 2. 94 403632 Target Exon 2. 27 2. 80 434232 AW297064 Hs. 131862 ESTs 2. 24 2. 98 428114 Ai821548 Hs. 98363 ESTs, Weakly similar to 138022 hypolhefi 2. 23 2. 81 403294 Target Exon 2. 19 2. 81 429249 X81479 Hs. 2375 egf-like module containing, mucin-like, 2. 16 3. 13 403295 Target Exon 2. 15 2. 95 427817 AA503373 Hs. 186678 ESTs 2. 13 2. 80 425154 NM 001851 Hs. 154850 collagen, type IY, alpha 1 2. 08 3. 28 443176 Al696081 Hs. 223770 ESTs 2. 04 3. 50 401770 C17001739-: gil2327052tgblMC48759. 1l (U9 2. 04 5. 39 407124 R08160 gb : yf18a07. s1 Soaresfetalliverspleen 2. 03 2. 95 456060 C14904 Hs. 45184 Homo sapiens cDNA FLJ 12284 fis, clone MA 2. 03 2. 97 413053 AW963263 Hs. 65377 ESTs, Moderately similar to KIAA1399 pro 2. 01 3. 42 426653 AA530892 Hs. 171695 dual specificity phosphatase 1 2. 01 3. 05 410677 Nom003278 Hs. 65424 tetranectin (plasminogen-binding protein 2. 01 3. 58 401673 C16001416' : gi12743112refXP 010131. 2 1. 99 4. 99 420983 W95228 Hs. 100764 cathepsin G 1. 95 5. 47 413624 BE177019 Hs. 75445 SPARGIike t (mast9, hevin) 1. 94 4. 58 433554 AW957666 Hs. 8108 disabled (Drosophila) homo) 1 1. 93 2. 82 405121 mitogen-activated protein kinase 8 inter 1. 92 2. 82 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 1. 92 2. 80 450852 AI983354 Hs. 7740 oxyslerol binding protein-like 1 1. 91 5. 08 432902 U75697 histone deacetylase 3 1. 90 2. 84 422100 A1096988 Hs. 111554 ADP-nbosyla60nfaCor-like7 1. 89 3. 04 420162 BE378432 Hs. 95577 cyclin-dependent kinase 4 1. 87 2. 85 424398 BE397787 Hs. 146393 homocysteine-inducible, endoplasmic reti 1. 85 3. 71 416714 AF283770 Hs. 79630 CD79A antigen (immunoglobulin-associated 1. 85 3. 38 433465 AV657778 Hs. 3314 selenoprotein P, plasma, 1 1. 85 3. 57 447990 BE048821 Hs. 20144 small inducible cytokine subfamily A (Cy 1. 82 6. 17 421563 NM_006433 Hs. 105806 granulysin 1. 80 3. 50 453804 AA300204 Hs. 35276 KIAA0852 protein 1. 78 2. 87

429412 NM 006235 Hs. 2407 POU domain, class 2, associating factor 1. 78 3. 54 437866 AA156781 metallothionein 1E (funcbonal) 1. 77 2. 97 427751 AF000152 conserved gene amplified in osteosarcoma 1. 75 6. 89 400442 DKFZP586G1722 protein 1. 74 3. 60 456898 NM 001928 Hs. 155597 D component of complement (adipsin) 1. 74 3. 45 414477 U41635 Hs. 76228 amplified in osteosarcoma 1. 71 4. 99 432870 AW974124 gb : EST386227 MAGE resequences, MAGM Homo 1. 68 2. 86 456642 AW451623 Hs. 109752 putative c-Myc-responsive 1. 68 3. 09 456694 AW016382 Hs105642 HomosapienscDNAFW23271fis cloneH 1. 66 2. 83 430449 AA352723 Hs. 241471 RNB6 1. 65 2. 84 401029 v-myc avian myelocytomatosis viral relat 1. 65 2. 88 402742 Nom002508 : Homo sapiens nidogen (enacbn) 1. 64 3. 37 402559 RhoGTPase activating protein 1 1. 63 3. 07 418271 NM 000919 Hs. 83920 peptidytgtycineatpha-amidatingmonooxyg 1. 62 3. il 406851 AA609784 major histocompatibiiity complex, dass 1. 62 2. 86 450912 AW939251 Hs. 25647 v-fos FBJ murineosteosarcoma viral onco 1. 60 3. 94 447029 AL137281 Hs. 17110 Homo sapiens mRNA ; cDNADKFZp434C2016 (f 1. 60 3. 75 417739 Z43995 gb : HSC1QB121nonmalizedinfantbraincDN 1. 59 2. 96 452950 AA428123 Hs. 302766 bnzsine 3-monooxygenaseXiryptophan Smo 1. 58 2. 95 427461 AA531527 Hs. 332040 hypothetical protein MGC13010 1. 58 4. 11 444182 AW160432 Hs296460 craniofæialdevelopmentpnotein1 1. 57 2. 98 407815 AW373860 Hs. 183860 hypothetical protein FW20277 1. 57 3. 88 452887 Api702223 Hs. 107253 hypothetical protein DKFZp761F241 1. 56 2. 88 416819 U77735 Hs. 80205 pim-2 oncogene 1. 56 3. 59 414583 AA362907 Hs. 76494 proline arginine-rich end leucine-rich 1. 56 4. 38 426104 A1204418 Hs. 190080 ESTs 1. 55 3. 47 441591 AF055992 Hs. 183 Duffy blood group 1. 52 4. 28 446406 A1553681 Arg/Abl-interacting protein ArgBP2 1. 49 2. 87 427343 A1880044 Hs. 176977 protein kinase C binding protein 2 1. 49 2. 88 415550 L13720 Hs. 78501 growth arrest-specific 6 1. 47 4. 82 411961 Al478432 Hs. 72956 hypermethytated in cancer 1 1. 46 3. 48 406213 ENSP00000246202' : DJ63M2. 2 (similar to AC 1. 42 3. 19 400847 NM_00310S : Homo sapiens sortilin-related 1. 41 2. 97 404642 NM021965' : Homo sapiens phosphoglucomuta 1. 40 3. 02 452650 AW270150 Hs. 254516 ESTs 1. 40 2. 86 432894 AW167668 Hs. 279772 brain specific protein 1. 37 5. 52 404030 NM015669' : Homo sapiens protocadherin be 1. 37 3. 03 422033 AW245805 Hs. 110903 daudin 5 (transmembrane protein deleted 1. 35 3. 15 413762 AW411479 Hs. 848 FK506-binding protein 4 (59kD) 1. 34 3. 09 425367 BE271188 Hs. 155975 protein tyrosine phosphatase, receptor t 1. 32 3. 29 415198 AW009480 Hs. 943 natural killer cell transcript 4 1. 32 2. 89 406908 Z25437 gb : H. sapiens protein-tyrosine kinase gen 1. 31 2. 89 423959 AA333025 gb : EST37122 Embryo, 8 week I Homo sapien 1. 31 2. 88 408135 AA317248 Hs. 42957 methyltransferase-like 1 1. 29 3. 81 427523 BE242779 Hs. 179526 upregulafed by 1 25-dihydroxyvitamin D-3 1. 29 3. 25 415512 Y16270 Hs. 78482 paralemmin 1. 29 2. 85 413531 AL036958 Hs. 75416 DAZ associated protein 2 1. 28 3. 06 419608 AL037237 Hs. 91586 transmembrane 9 superfamily member 1 1. 27 2. 80 424614 X54486 Hs. 151242 serine (orcysteine) proteinaseinhibito 1. 26 2. 90 422934 BE244189 Hs. 122492 hypothetical protein 1. 25 3. 41 450935 BE514743 tumor suppressor deleted in oral cancer-1. 25 3. 63 416630 H69392 Hs. 174051 smallnuc ! earribonucleoprotein70kDpol 1. 24 2. 93 416950 AL049798 Hs. 80552 dermatoponbn 1. 22 2. 81 412558 AW962019 gb : EST374092 MAGE resequences, MAGG Homo 1. 21 3. 02 419593 W73092 Hs. 58282 ESTs 1. 19 2. 84 403470 Target Exon 1. 14 2. 82 402230 Fgenesh predicted : CYTOCHROME P450 4F5 (1. 12 2. 96 400559 Target Exon 1. 00 2. 90 412695 AW984439 gb : PM3-HN0011-220300-002-cOSHNOO1 Homo 1. 00 2. 84 427072 H38046 Hs. 293981 ESTs 1. 00 2. 89 430439 AL133561 DKFZP434B061 protein 1. 00 3. 09 418183 NM_001772 Hs. 83731 CD33 antigen (gp67) 1. 00 2. 93 TABLE 55B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 406636 0 0 L12064 L12083 L12065 L12075 L12066 L12085 L12072 L12082 L12081 L12062 L12080 430540 713_2 BC017171 BC012195 NM 007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 B1759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 Al770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 Ai365196 AW337984 AW026150 BE466591 BE674599 Ai818438 AA772197 Ai651927 AW151143 Bi198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 Bol227204 BG761305 BE262642 BE391848 BE382475 BG008258 Bai547991 81459099 BE391391 BE259420 BE298109 AW245422 Al423847 Api914618 H80534 BE301004 AL531791 Ai435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 B1041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 Bol091658 N72512 W58732 W85690 BG958989 A1205206 H19721 W17051 W77958 Bl262010 M844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 A1027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 A1243844 AA809493 AA481029 AA825718 A1347866 A1431670 AA814436 A1251109 R07704 AA765606 AA724593 Al918399 A1537550 AA491103

AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 Bol860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 430015 713_2 BC017171 BC012195 NM 007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 B1759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 Api770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 BIS7204 BG761305 BE262642 BE391848 BE382475 BG008258 81547991 B1459099 BE391391 BE259420 BE298109 AW245422 Al423847 Al914618 H80534 BE301004 AL531791 A1435581 BF793112 AL577303 AA373265 8E746965 BF743630 BE879296 Api359493 BM018598 Al689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621 529 Al421 728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 B1041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 81091658 N72512 W58732 W85690 BG958989 AI205206 H19721 Wu 7051 W77958 81262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 M931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 A1027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 Al918399 Al537550 M491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 B1860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 455839 1518842_1 BE145823 BE145830 BE145884 BE145814 BE145905 BE145833 BE145834 BE145883 BE145889 406642 0 0 AJ245210 AJ245212 AJ245211 AJ245213 406638 0_0 M13861 433470 6624_1 X75684 A1573167 A1445461 A1453743 A1983655 A1564644 AA977180 A1694111 A1591358 AW071625 A1678712 A1720939 A1927769 BE439796 Al963432 M292956 AW192593 Ai865838 A1696905 A142U84 Al161312 Al911921 A1597801 Bl494959AI240988 Al492554 AW262737 BE044033 AW008570 AW629505 BI494958 AA088439 AA706057 BF222820 BF593608 BE501957 AA524526 BE044134 AW572531 AW015724 BE349186 AA043217 BE219784 AI799814 AA129575 AI671727 AI470033 BE646195 AW779725 AA903050 AA147228 AA404570 A1075878 W38161 Al972739 AW673152 AA723200 C06123 BF057147 AA627686 M157944 Ai990245 M662517 T32487 A1800106AI333170AI859160 W45410Ai990827 AW275048 M182640 M478328 Al298935 AW085158 AW471421 AW 103470 AW300456 AW 191997 AI823466 AA962397 AA136658 AI251817 AW339104 AA724739 AA411100 AA191349 AA757735 AA037696 AI769516 AW772283 AA010631 AI692846 AI061065 H80983 R79933 Api950693 AI245632 AI349390 AA148284 AI798502 AA487893 AI621320 AWt94272 C06365 AA953883 BE858936 AI918523 AI872628 Ai927217 AI453453 Al189366 AW338678 Al261359 Al500576 BF477735 A1032569 AI972899 AI985583 Z28771 AI363829 AI693030 AA603586 BE773488 AW339301 BE773489 BE773462 BE773495 A1650338 BE773499 A1745717 BE811475 BE811470 BE811464 BE811418 BE811415 BE811400 BE811398 BE811388 BE811352 BE773501 BE773494 BE773486 BE773474 BE773473 BE773470 BE773461 BE811350 BE811337 BF593847 BG055071 AW675302 BF003068 AA719173 BE811348 AI582462 AI686240 BE773500 AI244845 AI565439 AI918453 AI472527 A1446740 AA035576 AA191414 AW674145 C05782 AI589264 D57558 AI468237 AI432033 AA989662 R21752 BF002457 AA988297 AL574095 AL576200 AL571074 AL574525 AL578810 BG498381 Al928364 BE879732 AA479834 AA479712 Ct7732 BM091258 BF843901 AW820230 Ct7476 BE327120 AA129574 AA136645 BF843900 AW806193 AA502832 AA649494 AL568520 AL547960 BE706937 BE811360 BE773498 BE811401 BE773484 BE811437 BE811380 BE811399 BF997171 BF757734 BE926037 Al377596 C06111 AW088968 BE811404 BE811472 Al865912 Al925607 Ai871950 Al093510 BE905927 BE811435 AA191387 AVY772000 BE811453 BE614379 BF844522 Bl044896Ai744233AW984527 C17504 BF843883 AI248307 BE773483 AI567995 W60075 BF941183 Api738844 BE811458 BE773481 A1262930 AA948565 BE706942 BE156360 T65026 AW242958 AW197954 BE905184 AA722206 Al344943 Al348877 Al334860 BE621857 BE156280 AA454099 AA037722 BF843897 AW806183 AA043216 BG482896 AA182734 AA877242 AW372926 H27252 R38114 BF851858 BE156214 AA190427 T91762 AA035067 AA837326 T10930 BF906587 B1755027 BG506731 BC008442 BC010166 AL550134 AL553096 AL548700 AL550751 AL547978 AL545286 AL540643 AU118627 AL601379 Bol259821 BG741786 B1868522 AU135866 B1552770 B1259210 B1256520 B1255569 BG485098 Bol258228 BG498501 BM044512 AU133984 AL556586 BE745111 Bl222633 AU133917 BG288151 Bl260715 Bl550550 BGSW773 Bl551761 BG707601 81818593 BF691383 BG721129 BG541578 BE906666 BG751098 B1224135 BG400746 BG478065 BE790436 AW080238 AU137549 BG429896 BE392486 AW961686 BG721056 BE908365 BE546656 BG541235 AW583735 BG528290 81260895 AW651691 BM048974 BM043805 BG142185 AA315188 AI446615 C06300 BG497644 AA088544 AI815987 BG528631 BE619182 AW239185 AW062910 AW062902 AA347236 F11933AA488005 AA301631 AA376800 D56120 AA343532 AA308636 F00242 AA376086 AA316968 AA343799 B1870221 BE910282 BG538748 AW960564 AV732879 D16854 AA192519 BF922148 AA216013 BG624091 BE544387 BG507008 AW176446 BF790033 BE088925 BE088854 AA921353 R21800 AA011222 T97525 411802 609 6 BF345917 AL549635 B1040919 AA733204 AA232382 T34425 T32000 BF906697 Z42382 81544863 AL548378 AW816536 AW816719 BE152340 BF375392 AW816716 BE152336 BF375367 420223 191648_1 N27807 AA256634 BE276324 436729 6624 1 X75684 AL573167 A1445461 A1453743 A1983655 A1564644 AA977180 A1694111 A1591358 AW071625 A1678712 A1720939 A1927769 8E439796 AI963432 AA292956 AW192593 AI865838 AI696905 Ai424384 AI161312 AI911921 AI597801 81494959 AI240988 AI492554 AW262737 BE044033 AW008570 AW629505 81494958 AA088439 AA706057 BF222820 BF593608 BE501957 AA524526 BE044134 AW572531 AW015724 BE349186 AA043217 BE219784 At799814 M129575 Al671727 Al470033 BE646195 AW779725 AA903050 AA147228 AA404570 A1075878 W38161 Al972739 AW673152 AA723200 C06123 BF057147 AA627686 AA157944 AI990245 AA662517 T32487 AI800106 AI333170 AI859160 W45410 AI990827 AW275048 M182640 M478328 Al298935 AW085158 AW471421 AW103470 AW300456 AWt91997 AI823466 AA962397 AA136658 AI251817 AW339104 AA724739 AA411100 AA191349 AA757735 AA037696 AI769516 AW772283 AA010631 Al692846 Al061065 H80983 R79933 Al950693 AI245632 AI349390 AA148284 AI798502 AA487893 AI621320 AW194272 C06365 AA953883 BE858936 AI918523 AI872628 AI927217 AI453453 Ai189366 AW338678 AI261359 AI500576 BF477735 Al032569 Al972899 Al985583 Z28771 A1363829 A1693030 AA603586 BE773488 AW339301 BE773489 BE773462 BE773495 AI650338 BE773499 AI745717 BE811475 BE811470 BE811464 BE811418 BE811415 BE811400 BE811398 BE811388 BE811352 BE773501 BE773494 BE773486 BE773474 BE773473 BE773470 BE773461 BE811350 BE811337 BF593847 BG055071 AW675302 BF003068 AA719173 BE811348 AI582462 AI686240 BE773500 A1244845 A1565439 A1918453 A1472527 A1446740 AA035576 AA191414 AW674145 C05782 A1589264 D57558 A1468237 A1432033 AA989662 R21752 BF002457 AA988297 AL574095 AL576200 AL571074 AL574525 AL578810 BG498381 Al928364 BE879732 AA479834 AA479712 C17732 BM091258 BF843901 AW820230 C17476 BE327120 AA129574 AA136645 BF843900 AW806193 AA502832 AA649494 AL568520 AL547960 BE706937 BE811360 BE773498 BE811401 BE773484 BE811437 BE811380 BE811399 BF997171 BF757734 BE926037 Al377596 C06111 AW088968 BE811404 BE811472 Al865912 Al925607 Al871950 Al093510 BE905927 BE811435 AA191387 AW772000 BE811453 BE614379 BF844522 Bu044896 A1744233 AW984527 C17504 BF843883 A1248307 BE773483 A1567995 W60075 BF941183 Al738844 BE811458 BE773481 Al262930 M948565 BE706942 BE156360 T65026 AW242958 AW197954 BE5184 AA722206 A1344943 A1348877 A1334860 BE621 B57 BE 156280 AA454099 AA037722 BF843897 AW806183 AA043216 BG482896 AA182734 AA877242 AW372926 H27252 R38114 BF851858 BE156214 AA190427 T91762 AA035067 AA837326 T10930 BF906587 81755027 BG506731 BC008442 BC010166 AL550134 AL553096 AL548700 AL550751 AL547978 AL545286 AL540643 AU118627 AL601379 Bol259821 BG741786 BI868522 AU135866 B1552770 Bl2592iO B1256520 Bl255569 BG485098 Bol258228 BG498501 BM044512 AU133984 AL556586 BE745111 81222633 AU133917 BG288151 Bl260715 Bl550550 BGSW773 Bl551761 BG707601 Bol818593 BF691383 BG721129 BG541578 BE906666 BG751098 Bol224135 BG400746 BG478065 BE790436 AW080238 AU137549 BG429896 BE392486 AW961686 BG721056 BE908365 BE546656 BG541235 AW583735 BG528290 B1260895 AW651691 BM048974 BM043805 BG142185 M315188 Al446615 C06300 BG497644 AA088544 Api815987 BG528631 BE619182 AW239185 AW062910 AW062902 AA347236 F11933 AA488005 AA301631 AA376800 D56120 AA343532 AA308636 F00242 AA376086 AA316968 AA343799 B1870221 BE910282 BG538748 AW960564 AV732879 D16854 AA192519 BF922148 AA216013 BG624091 BE544387 BG507008 AW176446 BF790033 BE088925 BE088854 AA921353 R21800 AA011222 T97525 406782 00 AA430373AA968771 432902 35601_1 U75697 AI362269 AW575181 AL035820 AF039703 NM 003883 U66914 BE513355 BE302938 BE302936 BE303018 AA094475 F08725 R98879 R18769 BE019412AA045846AL120913 BE168807 BE168812 R21136 BE168915 H71247 N59055 AA533007 AW938705 BE260952 BE313803 AA307436 AW951917 AW581926 AW277164 Al439049 AW581905 Al744899 AW804572 BE004443 AA335928 AA486355 AAt 15468 AA312123 R77086 AA595186 AW166991 AI952071 AW593311 AW571813 AI749734 AI674761 AI560970 AI480266 AA534470 AA737815 BE300597 AW022818

BE300599'AA911621Ai074678BE300694Ai187018R98969AA456572Ai032 111Ai830414AA045874AA932352Ai871262T78896AA714518 AW009272 T17250 R76914 AW317029 H71248 AA931900 AA282808 A1032140 A1208512 A1244759 Ai420456 AI208085 AI283758 AI369297 R46731 H79779 Api349348 AW273644 AI559914 AI220114 AW615802 AA887531 AA810217 AA832227 A1567776 A1918324 AA862566 AA831038 AW246807 W78118 R43091 Z41762 AW135694 AW263376 AA115046 T34171 T34077 N53974 W79902 BE514017 BE513761 H79778 AW878598 437866 34267 1 U52054 AL581000 AA156850 AW293839 81335865 AA024963 BF149420 BE073977 AW602574 BE164012 BE163992 BE163974 AW402161 BM194134 AW966609 W84374 BF916380 AA385173 W84366 AA383743 BF903598 AA043776 W84421 AA778446 AW444904 BF446960 AA837481 AV755539 AW468444 AW468002 AA811830 AA581806 AI866686 AI572124 AA687333 D20160 AA812489 AU185248 AU186004 AA156781 AI536733 BM144850 AI471883 AA040926 BF507639AA043777 AW874142 BE832523 BE163972 Bl022546 Bl021204 427751 15028 1 BE875818 AW751975 W3924t BF808798 W22600 BF082190 AA031290 R42801 H98235 H17925 A1631236 AI933786 H42736 AF000152AUt23911 AW410526 BM354207 BF800492 BM142340 BE019322 AL597008 AW327818 Bl041915 AW504825 AW504941 BF987969 NM 005730 U81556 Al422831 AU154008 AA147822 AA873109 A1089244 AI360868 AW168024AI819848 AA811327 AI355616 AA281629 AI880578 AI274316 AW014622 AI268660 AI270283 AA171981 A1349410 AA402469 AI421985 A1004864 AI423497 AI361503 AI363096 AW805345 AL539999AA553967 AW502264 Api290698 N22420 Ai281054 Api500699 AW342095 C75122 AW504577 Al130811 AI423567 R79086AI860451 BE222885 AI697830AI279575 BF438693 AW576277 BE218210 Al952376 AA506609 Al147566 Al391690 M991622 Al696368 Al784664 M741555 Al002681 AW474554 AW474508 D25623 AI493929 AA179800 W73566 AW411368 AA147971 AA088581 BF804510 AU145809 AU148108 AA223219 AU157840 AW169757 AI537862 N42341 Al128667 AW327853 AA713915 W15255 W56743 AA058322 H81878 AA723464 N27523 R37745 AA613566 AL526353 AI905211 BF802713 N40338 AA249397 BF752939 BE250441 H64761 BF853011 H81877 H96088 AL576453 W73585 H39990 AW438965 BF899684 A1040299 AL561879 AA293821 H27760 BC018922 AL533396 BE513580 BF432649 A1884985 AA404264 AW024396 AW167863 AW027036AI302177 Al660487 AW026086 BF432564 BF091011 AI193156 AA744623 AI859510 81063081 81061541 AA777036 BG058486 81063555 AI349411 BF874521 AW139801 A1268585 AA401267 A1905209 R64276 N72043 AF022231 B1256540 AU134437 BG826972 BE298386AW134499 AW206089 BF846730 AW500331 BF849336 Bol041697 AI855774 AW192840 AW410527 AI697435 AW006631 AW504124 AL048926 A1085476 AW327855 AA459344 AW207516 AW204875 BM142514 BF436650AA960980 AW242609 Bt012363 AW837102 BE703126 BE814612 BE837981 BE703141 BP343101 R47375 AA031413 N40264 BG027363 BF526360 BE391263 AA280192 BE294042 BE250630 AU147734 AU146610 AA196787 N59465 AW575791 H16738 H96089 H64762 AW006603 BE857292AI719393AU155418 BG770385M339673 BG337748 H42694 BE834346 AA090896 BE619985BM006968 R46008 BF304621 AA172280 AW957721 BF304885 BF933455 BF809973 BG386280 AW079808 T51091 AL520569 BE694350 T06360 BF347780 BE560703 BE296629 432870 1238170_1 AW974124M572989M569080 406851 0_0 M609784 R97304 417739 2145372_1 R12357R34740Z43995 446406 11004_1 BG105015 R45824 Al659533 AW022952 BM312713 C04108 AU159507 AW290967 AW235078 AW271693 AA999835 AL134290 AW235222 BM312405 A1480093 AI469044 AI308242 AI274858 AI824850 A1093881 BE857254 AW235980 AI985474 AI540755 W17232 D56716 BE835412 AA091594 BE769194 BE769189 BE765413 BE766491 BF154895 BE765626 BF372247 BE769019 BE769122 8F154873 BF154880 Z26986 BE768478 Bof372008 T34949 BE768476 BE768462 BF370113 BE835323 BE769217 BE769113 AA093838 BE769188 N88480 AA093969 AA092843 423959 887999_1 BE273069 M333025 450935 4469_1 BE349913 BC002850 BC016704 NM005851 AF089814 AK001498 AL537879 BG754157 Al129659 Al261895 BG397540 BF663515 AW517226 BG677982 AI435188 AI453123 AI198380 AA524481 BG981512 AW269638 AI348113 A1095743 AA457108 AW044584 AU 151602 AI744572 A1078741 Al879729 Al089613 Al568618 BF109806 AW440972 M401965 Al027227 Al127506 M434027 BF732901 AW264768 AA833667 AL038554 Al568161 A1350340 AA402084 BE677778 AA933621 BF663514 BG763563 AL574521 BG177226 BG759860 BE906329 AW161323 Al879350 BF946477 BF766208 AA633194 AL537880 AL038553 BG468205 BG761617 81762655 BG436637 N49458 Bl834722 BG397879 81258799 AW004930 AA902847 AI832036 AW t 67549 AA743167 AA848017 AA365434 AI819503 AA767866 AI582000 N33615 AI950146 AA444029 AA227130 AA041525 AW339842 AA865972 Axa838006 AW157822 Al890994 Bl771150 Bl821666 BE279491 412558 1227364 1 AW962019 BE389091 412695 1243394 1 AW984433AW984393AW984439AW984451 AW984367AW984371 AW9Ei4349AW984356AW984444AW984443AW984449 430439 6750_2 AL133561 AL117481 AL122069 AW439292 Api968826 AL041090 TABLE 55C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers.'Dunham, et a !. * refers to the publication en6Ued The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleoGde positions of predicted exons. Pkey Ref Strand Nt_position 404854 7143420 Plus 14260-14537 402294 2282012 Minus 2575-3000 402737 9212184 Minus 13358-13552 404995 6006247 Minus 154015-154123 401284 9800819 Minus 101307-101421 405757 3334694 Minus 66825-70466 401731 9690317 Plus 43830-43963, 44787-44935, 45698-45810, 4741 401979 2828778 Minus 75693-75851, 76977-77112 401112 9966198 Minus 60628-61041 402692 8468956 Plus 124606-125387 404049 3688074 Minus 75765-78155 404752 7109522 Minus 120168-120326 403632 8572864 Minus 35197-35358 403294 8096496 Plus 41565-41881 403295 8096528 Plus 22386-22708 401770 9958312 Plus 183424-183576 401673 7689903 Minus 122587-122705, 122765-123047 405121 8102330 Minus 35816-36004, 36587-36684 400442 9887672 Plus 59362-59574 401029 8117523 Pius 41999-42172 402742 9212200 Minus 23487-23613 402559 9864273 Plus 33539-33715 406213 7342019 Plus 25921-26612, 34539-35161 400847 9188605 Plus 44643-44835 404642 9796810 Plus 102999-103145 404030 7671252 Plus 149362-151749 403470 9929739 Minus 8376-8552 402230 9966312 Minus 29782-29932 400559 9843598 Plus 75483-75584

TABLE 56A : ABOUT 277 GENES UPREGULATED IN MELANOMA METASTASES RELATIVE TO BENIGN NEVI Table 56A lists about 277 genes upregulated in melanoma metastases relative to benign nevi. Genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al) a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Tide : Unigene gene title R1 : 70th percentile of melanoma metastasis Als divided by the maximum of benign nevi Als R2 : 70th percentile of melanoma metastasis Als divided by the maximum of benign nevi Als, where the 15th percenGle of normal 6ssue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 422424 Al186431 Hs. 296638 prostate differentiation factor 13. 73 17. 18 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (asteopontin, 11. 67 13. 25 407846 AA426202 Hs. 40403 Cbp/p30-interacting ransac6vator, wit 9. 35 8. 75 444381 BE387335 Hs. 283713 ESTs. Weakly similar to S64054 hypotheb 8. 63 6. 22 417880 BE241595 Hs. 82848 selectin L (lymphocyte adhesion molecule 8. 21 8. 65 424321 W74048 Hs. 1765 iymphocyte-specificproteinbrosinein 7. 13 5. 04 447210 AF035269 Hs. 17752 phosphafidylsedne-specific phospholipas 6. 79 7. 12 417693 AW959741 Hs. 40368 adaptor-related protein complex 1, sigma 6. 55 5. 94 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactin) 6. 43 3. 46 414812 X72755 Hs. 77367 monokine induced by gamma interferon 6. 43 5. 44 451736 AW080356 Hs. 23889 ESTs Weakly similar to ALU7 HUMAN ALU S 6. 31 6. 08 418870 AF147204 Hs. 89414 chemokine (C-X-CmoUfl eceptor4 (fus 6. 20 6. 04 428291 AA534009 Hs. 183487 interferon stimulated gene (20kD) 6. 03 4. 72 417308 H60720 Hs. 81892 KIAA0101 gene product 6. 01 7. 07 448569 BE382657 Hs. 21486 signal transducer and activator of trans 5. 99 8. 88 439310 AF086120 Hs. 102793 ESTs 5. 95 6. 63 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 5. 95 3. 77 422241 Y00062 Hs. 170121 protein tyrosine phosphatase, receptor t 5. 76 6. 37 442379 NM 004613 Hs. 8265 transglutaminase 2 (C polypeptide, prote 5. 76 3. 14 409274 NM 003930 Hs. 52644 SKAP55 homologue 5. 65 5. 01 442739 NM007274 Hs. 8679 cytosolic acyl coenzyme A thioester hydr 5. 58 3. 50 442711 AF151073 Hs. 8645 hypothetical protein 5. 45 5. 84 425118 AU076611 Hs. 154672 methylene tetrahydrofolate dehydrogenase 5. 42 5. 75 412918 BE563957 activated RNA polymerase 11 transcrip60 5. 35 4. 94 428125 AA393071 Hs. 182579 leucine aminopep6dae 5. 33 5. 34 446921 AB012113 Hs. 16530 small inducible cytokine subfamily A (Cy 5. 33 4. 98 431183 NM 006855 Hs. 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic retic 5. 30 6. 25 414219 W20010 Hs. 75823 ALLt-fused gene from chromosome 1q 5. 16 5. 33 426600 NM003378 Hs. 171014 VGF nerve growth factor inducible 5. 05 8. 77 415444 BE247295 Hs. 78452 solutecaTierfamily20 (phosphatetran 5. 03 5. 17 436701 AW959032 ESTs Moderately similar to 178885 serin 5. 03 4. 17 406648 AA563730 Hs. 277477 major histocompatibiiity complex, class 4. 99 5. 08 410850 AW362867 Hs. 302738 Homo sapiens cDNA : FLJ21425 fis, clone C 4. 98 4. 71 418299 AA279530 Hs. 83968 integrin. beta 2 (antigen CD18 (p95), ly 4. 98 4. 08 432469 AL080084 CGI-100 protein 4. 97 4. 70 404854 Target Exon 4. 85 4. 07 415701 Nom-003878 Hs. 78619 gamma-glutamyihydrolae (conjugase fol 4. 82 4. 90 425397 J04088 Hs. 156346 topoisomerase (DNA) it alpha (170kD) 4. 81 3. 45 408958 T99607 Hs. 49346 signal recognition particle 54kD 4. 78 2. 34 453949 AU077146 Hs. 36927 heat shock 105kD 4. 78 6. 32 458079 A1796870 Hs. 54277 DNA segment on chromosome X (unique) 992 4. 77 6. 57 440245 AK001913 Hs. 7100 hypothetical protein 4. 74 3. 83 412228 AW503785 Hs. 73792 complementcomponent (3d/EpsteinBarrvi 4. 74 5. 53 417834 BE172058 Hs. 82689 tumor rejection antigen (gp96) 1 4. 73 4. 35 451003 AF058696 Hs. 25812 Nijmegen breakage syndrome 1 (nibhn) 4. 67 4. 60 424571 BE379766 polymerase (RNA) 11 (DNA directed) polyp 4. 62 3. 50 434203 BE262677 Hs. 283558 hypothetical protein PR01855 4. 61 5. 67 452268 NM003512 Hs. 28777 H2A histone family, member L 4. 60 3. 79 421311 N71848 Hs. 283609 hypothetical protein PR02032 4. 60 3. 58 410491 AA465131 Hs. 64001 Homo sapiens clone 25218 MRNA sequence 4. 60 4. 68 425706 AW406678 Hs. 122559 hypothetical protein FU22570 4. 59 3. 83 450293 N36754 Hs. 171118 hypothetical protein FLJ00026 4. 57 5. 40 406836 AW514501 Hs. 156110 immunoglobulin kappa constant 4. 57 6. 33 413441 A1929374 Hs. 75367 Src-like-adapter 4. 53 4. 77 431129 AL137751 Hs. 263671 Homo sapiens mRNA ; cDNA DKFZp43410812 (f 4. 48 4. 89 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 4. 47 4. 17 411060 Nom006074 Hs. 318501 Homo sapiens mRNA full length insert cDN 4. 47 4. 33 417501 AL041219 Hs. 82222 sema domain, immunoglobulin domain (Ig), 4. 45 3. 32 437763 AA469369 Hs. 5831 tissue inhibitor of metalloproteinase 1 4. 43 4. 43 448883 BE614989 Hs. 7503 hypothetical protein FLJ14153 4. 42 3. 91 417274 N92036 Hs. 81848 RAD21 (S. pombe) homolog 4. 41 4. 09 419285 D31887 Hs. 89868 KIAA0062 protein 4. 40 3. 56 418321 D63477 Hs. 84087 KIAA0143 protein 4. 38 3. 00 430154 AW583058 Hs. 234726 senne (or cysteine) proteinase inhibito 4. 37 4. 26 428450 NM 014791 Hs. 184339 KIAA0175 gene product 4. 36 4. 90 428297 AA236291 Hs. 183583 serine (or cysteine) proteinase inhibito 4. 36 3. 57 447232 AW499834 Hs. 327 interleukin 10 receptor, alpha 4. 36 4. 07 409598 NM 014018 Hs. 55097 mitochondriatribosoma ! protein S28 4. 35 3. 29 442432 BE093589 Hs. 38178 hypothetical protein FLJ23468 4. 34 5. 80 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 4. 33 3. 51

443991 NM_002250 Hs. 10082 potasiumintemmediate/smal ! conductance 4. 33 4. 23 452322 BE566343 Hs. 28988 glutaredoxin (thioltransferase) 4. 32 2. 68 420991 AW504814 Hs. 287379 HomosapiensmRNAforFW00111 protein, 4. 32 4. 54 449722 BE280074 Hs. 23960 cyclic but 4. 31 3. 73 408380 AF123050 Hs. 44532 diubiquitin 4. 30 5. 74 427127 AW802282 Hs. 22265 pyruvate dehydrogenase phosphatase 4. 28 4. 80 417933 X02308 Hs. 82962 thymidylate synthetase 4. 28 3. 59 432828 AB042326 Hs. 287402 chondroitn 4-suWotransérae 4. 25 4. 15 450306 AL080080 Hs. 24766 thioredoxin domain-containing 4. 24 3. 15 440266 AA088809 Hs. 19525 hypothetical protein FU22794 4. 23 4. 12 407951 W77762 Hs. 79015 antigen identified by monoclonal an6bod 4. 22 4. 64 427337 Z46223 Hs. 176663 Fc fragment of IgG, low affinity Ilib, r 4. 20 4. 62 408989 AW361666 Hs. 49500 KIAA0746 protein 4. 20 4. 92 449626 AA774247 Hs. 301637 zinc finger protein 258 4. 19 3. 17 422846 BE513934 Hs. 1583 neutrophil cytosolic factor 1 (47kD, chr 4. 18 8. 91 415726 T89844 Hs. 78712 aminolevulinate, delta-, synthase 1 4. 16 4. 21 444207 AI565004 cathepsin D (lysosomal aspartyl protease 4. 16 1. 89 416980 AA381133 Hs. 80684 high-mobility group (nonhistone chromoso 4. 14 3. 30 438718 AL040058 Hs. 6375 uncharactehzedhypothatamus protein HTO 4. 14 3. 04 437802 Api475995 Hs. 122910 ESTs 4. 12 5. 13 446392 AF142419 Hs. 15020 homologofmousequakingQKl (KHdomain 4. 12 3. 87 409461 AA382169 Hs. 54483 N-myc (and STAT) interactor 4. 11 4. 96 427247 AW504221 Hs. 174103 integrin, alpha L (an6gen CD11A (p180), 4. 11 6. 37 414359 M62194 Hs. 75929 cadhenn11, Wpe2, OEcadherin (osteob 4. 10 4. 16 450071 AA018283 Hs. 24359 HomosapienscDNAFU11174fis. ctonePL 4. 10 2. 35 452882 AW972990 Hs. 196270 folate transporter/camer 4. 10 4. 50 414522 AW518944 Hs. 76325 Immunoglobulin J chain 4. 09 6. 07 407756 AA116021 Hs. 38260 ubiquitin specific protease 18 4. 09 5. 03 405506 Target Exon 4. 08 3. 71 417497 AW402482 Hs. 82212 CD53 antigen 4. 07 8. 61 413715 AW851121 Hs. 75497 HomosapienscDNA FLJ22139fis, cloneH 4. 06 4. 05 421508 NM_004833 Hs. 105115 absent in melanoma 2 4. 05 4. 61 445701 AF055581 Hs. 13131 lymphocyte adaptor protein 4. 02 4. 56 443071 AL080021 Hs. 8986 complement component 1, q subcomponent, 4. 00 8. 91 417615 BE548641 Hs. 82314 hypoxanthinephosphoribosyitransferasel 3. 99 4. 15 444371 BE540274 Hs. 239 forehead box M1 3. 86 4. 58 450515 AW304226 biphenyl hydrolase-like (serine hydrolas 3. 85 4. 26 446506 Al123118 Hs. 15159 chemokine-likefactor, åtema6velyspl 3. 81 4. 06 410668 BE379794 Hs. 159651 hypothetical protein 3. 80 6. 84 443710 Al928136 Hs. 9691 Homo sapiens cDNA : FLJ23249 fis, clone C 3. 77 4. 46 406837 R70292 Hs. 156110 immunoglobulin kappa constant 3. 77 6. 44 419381 AB023420 Hs. 90093 heat shock 70kD protein 4 3. 76 4. GO 402474 Nom-004079 : Homo sapiens cathepsin S (CTSS 3. 76 4. 67 454080 A1199711 Hs. 576 fucosidase, alpha-L-1, tissue 3. 74 6. 22 409264 NM 014937 Hs. 52463 KIAA0966 protein 3. 69 4. 36 428398 Al249368 Hs. 98558 ESTs 3. 68 5. 18 423494 AW504365 Hs. 24143 Wiskott-Alddch syndrome protein interac 3. 67 4. 12 414829 AA321568 Hs. 77436 pleckstrin 3. 65 4. 45 437239 AW503395 Hs. 5541 ATPase, Ca transporting, ubiquitous 3. 63 4. 84 433867 AK000596 Hs. 3618 hippocalcin-like 1 3. 59 4. 49 432485 N90866 Hs. 276770 CDW52 antigen (CAMPATH-1 antigen) 3. 54 5. 31 418310 AA814100 Hs. 86693 ESTs 3. 49 4. 57 406868 AA505445 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 3. 48 4. 33 438746 Al885815 Hs. 184727 Human melanoma-associated an6gen p97 (m 3. 47 6. 87 427527 A1809057 Hs. 153261 immunoglobulin heavy constant mu 3. 44 10. 42 442485 BE092285 Hs. 29724 hypothetical protein FU13187 3. 41 4. 60 432606 NM002104 Hs. 3066 granzyme K (serine protease, granzyme 3 ; 3. 40 4. 50 435080 Ai831760 Hs. 155111 hypothetical protein FLJ14428 3. 40 4. 22 436810 AA353044 Hs. 5321 ARP3 (actin-related protein 3, yeast) ho 3. 40 5. 03 422545 X02761 Hs. 287820 fibronectin 1 3. 39 7. 32 409142 AL136877 Hs. 50758 SMC4 (structural maintenance of chromoso 3. 36 4. 47 434826 AF155661 Hs. 22265 pyruvate dehydrogenase phosphatase 3. 34 5. 02 416975 NM 004131 Hs. 1051 granzyme B (granzyme 2, cytotoxic T-lymp 3. 34 4. 24 448410 AK000227 Hs. 21126 hypothetical protein FLJ20220 3. 33 4. 29 432642 BE297635 Hs. 3069 heat shock 70kD protein 9B (mortalin-2) 3. 32 4. 48 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypotheti 3. 24 4. 64 443623 AA345519 Hs. 9641 complement component 1, q subcomponent, 3. 23 13. 58 426490 NM 001621 Hs. 170087 aryl hydrocarbon receptor 3. 23 4. 20 443958 BE241880 Hs. 10029 cathepsin C 3. 16 5. 05 407862 BE548267 Hs. 337986 Homo sapiens cDNA FLJ 10934 fis, cbne OV 3. 15 4. 04 412577 Z22968 Hs. 74076 CD163 antigen 3. 14 5. 32 414050 NM_004766 Hs. 75724 coatomer protein complex, subunit beta 2 3. 13 4. 65 442904 AW575008 Hs. 11355 thymopoietin 3. 13 4. 34 421633 AF121860 Hs. 106260 sorting nexin 10 3. 12 4. 99 413936 AF113676 Hs. 297681 serine (orcysteine) proteinaeinhibito 3. 11 5. 47 428797 AA496205 Hs. 193700 HomosapensmRNA ; cDNADKFZpS8610324 ( 3. 10 4. 30 408515 Api289507 Hs. 299883 hypothetical protein FLJ23399 3. 10 4. 03 409442 AA310162 Hs. 169248 cytochrome c 3. 07 4. 00 456373 BE247706 Hs. 89751 membrane-spanning 4-domains, subfamily A 3. 04 4. 38 430413 AW842182 Hs. 241392 small inducible cytokine A5 (RANTES) 3. 04 5. 53 418526 BE019020 Hs. 85838 solute carrier family 16 (monocarboxylic 3. 03 4. 97 452139 AA099969 Hs. 16331 Homo sapiens cDNA : FLJ21482 fis, clone C 3. 01 4. 87 430478 NM_014349 Hs. 241535 apolipoprotein L, 3 2. 98 4. 44

439237 AW408158 Hs. 318893 ESTs, WeaklysimilartoA47582B-celigr 2. 95 7. 45 406782 AA430373 gb : zw20f11. s1 Soares ovary tumor NbHOT H 2. 93 8. 49 450455 AL117424 Hs. 25035 chlorideintracellularchannel4 2. 90 5. 08 422530 AW972300 Hs. 118110 bone marrow stromal cell antigen 2 2. 87 7. 07 429490 Api971131 Hs. 23889 ESTs, Weakly similar to ALU7 HUMAN ALU S 2. 87 4. 29 410231 AA314163 Hs. 61153 proteasome (prosome, macropain) 26S subu 2. 82 5. 53 419956 AL137939 Hs. 40096 cadherin 19, type 2 2. 80 4. 26 416511 NM 006762 Hs. 79356 Lysosomai-associatedmuttispanningmembr 2. 79 5. 55 421712 AK000140 Hs. 107139 hypothetica ! protein 2. 79 6. 29 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2 doma 2. 78 4. 74 448517 AA082750 Hs. 42194 hypothetica) proteinFU22649simiiarto 2. 78 4. 69 427792 M63928 Hs. 180841 tumor necrosis factor receptor superfami 2. 77 5. 18 446272 BE268912 Hs. 14601 hematopoietic cell-specific Lyn substrat 2. 75 4. 90 422173 BE385828 Hs. 250619 phorbolin-likeproteinMDS019 (CEM15) 2. 75 4. 33 446566 H95741 Hs. 17914 membrane-spanning 4-domains, subfamily A 2. 72 4. 19 429402 AF116571 Hs. 201671 SRY (sex determining region Y)-box 13 2. 72 5. 15 421360 AA297012 Hs. 103839 erythrocyte membrane protein band 4. 1-li 2. 71 4. 82 425762 BE244076 Hs. 159578 AT-hooktTanscnp60nfætorAKNA 2. 71 4. 61 429412 NM_006235 Hs. 2407 POU domain, class 2, associating factor 2. 69 4. 45 409202 AA236881 Hs. 51043 hexosaminidase B (beta polypepfide) 2. 68 4. 89 426124 AI268389 Hs. 250697 phosphafidylinositol glycan, class F 2. 68 4. 25 422672 X12784 Hs. 119129 collagen, type IV, alpha 1 2. 67 5. 00 417389 BE260964 Hs. 82045 midkinefneunte growth-promoting factor 2. 65 9. 54 445784 A1253155 Hs. 146065 ESTs 2. 65 4. 11 410341 AW499985 Hs. 42915 ARP2 (actin-related protein 2, yeast) ho 2. 64 4. 50 422603 BE242587 Hs. 118651 hematopoieticatiy expressed homeobox 2. 63 4. 17 424687 J05070 Hs. 151738 matrix metalloproteinase 9 (gela6nase B 2. 62 5. 80 410016 AA297977 Hs. 57907 small inducible cytokine subfamily A (Cy 2. 61 5. 57 424779 AL046851 Hs. 153053 CD37 antigen 2. 60 5. 72 420224 M84371 Hs. 96023 CD19 antigen 2. 60 4. 02 421924 BE514514 Hs. 109606 coronin, ac6n-binding protein, 1A 2. 57 4. 83 426143 BE379836 proteasome (prosome, macropain) subunit, 2. 56 4. 50 421563 NM 006433 Hs. 105806 granulysin 2. 56 5. 35 425593 AA278921 Hs. 1908 proteoglycan 1, secretory granule 2. 55 4. 32 428169 A1928984 Hs. 182793 golgi phosphoprotein 2 2. 54 5. 78 417022 NM 014737 Hs. 80905 Ras association (RaiGDS/AF-6) domain fam 2. 54 4. 09 414646 AA353776 Hs. 901 CD48 antigen (B-cell membrane protein) 2. 53 4. 41 429800 AA333375 Hs. 223014 antizyme inhibitor 2. 50 5. 68 407241 M34516 gb : Human omega light chain protein 14. 1 2. 50 4. 69 421739 AB004550 Hs. 107526 UDP-Gal : betaGicNAc beta 1, 4- galactosylt 2. 45 4. 35 412819 T25829 Hs. 24048 FK506 binding protein precursor 2. 45 4. 66 435523 T62849 Hs. 11090 membrane-spanning 4-domains, subfamily A 2. 44 4. 91 434883 AW381538 Hs. 19807 hypothetical protein MGC12959 2. 41 4. 80 420340 NM 000734 Hs. 97087 CD3Z antigen, zeta polypeptide (TiT3 com 2. 41 4. 00 449296 AL137257 Hs. 23458 Homo sapiens cDNA : FU23015 fis, clone L 2. 41 4. 77 417370 T28651 Hs. 82030 tryptophanyl-tRNA synthetase 2. 41 4. 04 400223 Eos Control 2. 39 5. 47 431629 AU077025 Hs. 265827 interferon, alpha-inducible protein (clo 2. 38 7. 67 414622 A1752666 Hs. 76669 nicotinamide N-methyltransferase 2. 38 5. 32 415149 X12451 Hs. 78056 cathepsin L 2. 37 8. 07 435099 AC004770 Hs. 4756 flap structure-specific endonuclease 1 2. 37 5. 23 454390 AB020713 Hs. 56966 KIAA0906 protein 2. 35 4. 57 427407 BE268649 Hs. 177766 ADP-dbosyltransferase (NAD ; poly (ADP-r 2. 31 5. 48 449029 N28989 Hs. 22891 solutecarnerfamily7 (cabonicamino 2. 24 4. 08 438956 W00847 Hs. 135056 Human DNA sequence from clone RP5-850E9 2. 23 4. 02 423397 NM001838 Hs. 1652 chemokine (C-C motif) receptor 7 2. 23 4. 90 416232 AW502678 Hs. 79090 exportin 1 (CRM1, yeast, homolog) 2. 18 4. 97 436692 AW243158 Hs. 5297 DKFZP564A2416 protein 2. 17 4. 13 420842 A1083668 Hs. 50601 hypothe6cal protein MGC10986 2. 14 5. 14 428227 AA321649 Hs. 2248 small inducible cytokine subfamily B (Cy 2. 13 4. 43 429642 X68264 Hs. 211579 melanoma cell adhesion molecule (MCAM) (2. 11 5. 42 416448 L13210 Hs. 79339 lectin, galactoside-binding, soluble, 3 2. 10 6. 36 416714 AF283770 Hs. 79630 CD79A antigen (immunoglobulin-associated 2. 10 4. 06 409220 BE243323 Hs. 51233 tumor necrosis factor receptor superfami 2. 09 4. 67 414045 NM 002951 Hs. 75722 ribophorin 11 2. 07 4. 32 422451 AA310753 Hs. 42491 ESTs, Weakly similar to S65657 alpha-G 2. 07 4. 24 441211 AW946155 Hs. 7750 hypothetical protein AL133206 2. 06 4. 64 434692 H06586 Hs. 94 DnaJ (Hsp40) homolog, subfamily A, membe 2. 05 4. 33 452363 A1582743 Hs. 94953 Homo sapiens, Similar to complement comp 2. 04 13. 36 438393 AA351815 Hs. 50740 Homo sapiens cDNA : FU22272 fis, clone H 2. 03 4. 52 413313 NM 002047 Hs. 283108 glycyl-tRNA synthetase 2. 02 4. 11 452700 Al859390 Hs. 288940 five-span transmembrane protein M83 2. 00 4. 04 406621 X57809 Hs. 8997 immunoglobutin lambda locus 1. 99 4. 35 424415 NM001975 Hs. 146580 enolase 2, (gamma, neuronal) 1. 98 4. 52 429451 BE409861 Hs. 202833 heme oxygenae (decycling) 1 1. 95 5. 60 416967 BE616731 Hs. 80645 interferon regulatory factor 1 1. 95 5. 38 414945 BE076358 Hs. 77667 lymphocyte an6gen 6 complex, locus E 1. 93 4. 69 418917 X02994 Hs. 1217 adenosine deaminase 1. 91 4. 32 445411 AL137255 Hs. 12646 hypothetical protein FLJ22693 1. 91 4. 48 413945 NM 000591 Hs. 75627 CD14 antigen 1. 90 6. 03 429119 AV660012 Hs. 196437 hypotheticaproteinFW10788 1. 90 4. 08 413317 U53225 Hs. 75283 sorting nexin 1 1. 89 4. 06 427239 BE270447 ubiquitin carrier protein 1. 87 5. 98

450440 AB024334 Hs. 25001 tyrosine 3-monooxygenase/tryptophan Smo 1. 87 6. 33 413142 M81740 Hs. 75212 omithinedecaboxylae1 1. 85 4. 21 447131 NM 004585 Hs. 17466 retinoic acid receptor responder (tazaro 1. 84 5. 07 430040 AW503115 Hs. 227823 pM5 protein 1. 83 5. 57 416819 U77735 Hs. 80205 pim-2 oncogene 1. 83 4. 12 425356 BE244879 Hs. 155939 inositol polyphosphate-5-phosphatase, 14 1. 82 5. 71 414570 Y00285 Hs. 76473 insulin-like growth factor 2 receptor 1. 81 4. 73 443639 BE269042 Hs. 9661 proteasome (prosome, macropain) subunit. 1. 80 4. 71 418707 U97502 Hs. 87497 butyrophilin, subfamily 3, member A2 1. 78 5. 16 425367 BE271188 Hs. 155975 protein tyrosine phosphatase, receptor t 1. 78 7. 00 409154 U72882 Hs. 50842 interferon-induced protein 35 1. 74 5. 10 444954 AW247076 Hs. 12163 eukaryo6c translation initia6on factor 1. 71 5. 15 424825 AF207069 Hs. 153357 procollageMysine, 2-oxoglutarate Sdio 1. 70 4. 43 428385 AF112213 Hs. 184062 putative Rab5-interacting protein 1. 69 4. 06 427378 BE515037 Hs. 177556 melanoma antigen, family D, 1 1. 67 5. 68 413322 AA380158 Hs. 75290 ADP-ibosyla6on factor 4 1. 67 4. 56 442414 BE408758 Hs. 8297 ribonuclease6precursor 1. 65 4. 40 410129 BE244074 Hs. 58831 eguiatorofFasinducedapoptosis 1. 64 4. 02 452472 AW957300 Hs. 294142 ESTs, Weakly similar to C55663 oligodend 1. 63 4. 49 446143 BE245342 Hs. 306079 sec61 homolog 1. 62 4. 73 413511 Al627178 Hs. 75412 arginine-rich, mutated in early stage tu 1. 60 4. 19 415017 F06434 Hs. 77805 ATPase, H transporting, lysosomal (vacuo 1. 60 4. 61 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-1. 59 4. 26 410068 Api633888 Hs. 58435 FYN-binding protein (FYB-120/130) 1. 56 4. 10 419489 AW411280 Hs. 90693 replication initiation region protein (6 1. 55 4. 30 439627 BE621702 Hs. 29076 hypothetical protein FLJ21841 1. 55 6. 54 414427 L19711 Hs. 76111 dystrogiycanlfdystrophin-associatedg) 1. 53 4. 00 416971 R34657 Hs. 80658 uncoupling protein 2 (mitochondrial, pro 1. 53 4. 79 426059 BE292842 Hs. 166120 interferon regulatory factor 7 1. 51 4. 12 418879 AW162087 Hs. 5437 Taxi (human T-cell leukemia virus type 1 1. 50 4. 93 433271 BE621697 Hs. 14317 nucleolar protein family A, member 3 (H/1. 45 4. 15 422481 AL050163 Hs. 117339 DNAX-acbvation protein 10 1. 45 4. 03 432805 X94630 Hs. 3107 CD97 antigen 1. 43 4. 11 447150 Api439011 Hs. 86386 myeloidselileukemiasequence1 (BCL2-r 1. 43 4. 08 421975 AW961017 Hs. 6459 hypothetcal protein FLJ 11856 1. 41 4. 36 427458 BE208364 Hs. 29283 ESTs, Weakly similar to LKHU proteoglyca 1. 41 4. 10 412968 AW500508 Hs. 75102 alanyl-tRNA synthetase 1. 40 4. 25 428511 AA019912 Hs. 184693 transcrip6on elongation factor B (SIII) 1. 38 4. 91 413825 BE299181 Hs. 75564 CD151 antigen 1. 37 4. 46 427496 D21260 Hs. 178710 clathrin, heavy poiypeptide (He) 1. 30 4. 04 407143 C14076 Hs. 332329 EST 1. 29 4. 37 TABLE 56B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 412918 27643 BE784583 AL519009 AV755430 AV756363 AV711927 B1523434 A1521453 AA846815 AW024829 AW949702 BG218926 AA626658 Al445621 Ai452815 AA946555 AA723580 AA612925 BG105326 BG532618 AW513994 AW602165 AI373448 AA907901 AW135104 BGi86662 W69205 BG219754 BE774875 BG190378 AA483698 BE066066 BE066067 BE066062 AW304207 BE939361 AW795569 BG210592 AW795644 BE939358 AW102886 BE065977 BG182971 H97042 D58090 B1046351 H81248 A1750112 AW372079 C05492 D58287 D57835 AA935095 BF700910 BG215802 BG195459 AW368467 BG495535 BG533177 Bol087962 BE541579 BF130753 436701 28142_1 Z69892 AA210833 BM353155 A1473754 A1147901 A1803109 AA843296 AA418925 A1478552 A1400067 A1360304 AA418828 AW301673 BE218952 Ai632804 BF433234 AA394157 BF378047 BE467036 AA319724 AW290940 A1222671 A1347724 AW001711 A1028652 AA398130 A1470582 Ai915936 AA908929 C75102 N36920 H50440 AI919034 A1004399 AI383862 AI123606 AA648518 AA516258 A1865321 N22865 AA848101 AI589792 AA758196 AA214630 Ai373911 AW194733 AA213447 Ai290291 BF437165 AA757592 BF086904 AW959032 AW992466 BF446888 Al936337 BE938849 AW149064 Al701629 N9W21 432469 58644_1 BC016556 BC016365 NM-016040 AF151858 B1561037 AW966873 AW967497 BE219482 BE018650 AW770511 AW46905 AW470133 BM150181 BM193977 Al824135 Al632346 Al129838 BM147664 Al292112 BE244667 AA251084 AW503659 BM193866 BM194481 BF446862 AL597435 BF000262 Al824386 Al990100 AW087624 AA668793 AL080084 Bl335866 Bl820940 BG779242 BM069854 AA282620 AA256771 AW96451 i AA451623 H00335 AW370399 AW954201 BMt 45846 BGt 11760 AI750065 BG655794 AA564086 BG494071 BM069606 AI675331 BE302224 AI476466 AI625980 BM144854 At184602Ai343932AW136586 AW029464 Ai708651 AA824243 BM145917 AA662210 AA825708 AI335858 AI273704 AA662171 N48971 AA976614 A1344537 AA609603 A1873901 A1859995 AA833589 AA765811 Al 150322 A1926816 BM148634 N98862 AA019347 AA897062 AA831 100 N69889 BE243185 AA282179 AA831098 AA112676 AI702407 BG621752 BE006492 AA353202 BG674256 N46921 BI048774 AW300233 BF739890 AW966879 AA393405 BF1 15146 AA910851 AA01 3099 N28878 AA287713 BE348728 BG616446 AL599953 AL599952 BF381073 AW505056 AA094735 H03613 AA287714 H27168 R54718 BF792697 AV693603 AV685883 BG619956 BF541504 BF216789 AA319751 BM452652 BF335838 AA280397 BG171509 BF571997 AA490239 AW388161 BE842126 BG165309 N71903 At955397 Api536898 BE242040 F09718 AA772421 AA450218 M78543 BE241414 AA013098 H00297 AW576477 AW150918 AW591371 A1382711 N71926 H72497 A1285602 AA745055 A1281647 BF377670 T65207 BG532880 BG721680 AA285143 H27167 AW500235 BG494497 BF668899 424571 9758 1 BE379766 AW152643 Al803450 Al564343 Al092711 Al140525 AW152156 Ai620740 A1554689 At161209 A1290242 A1339745 AI374611 AI347388 A1858296 A1140529 A1366124 AA493912 AA406235 AA493889 A1057160 AW022264 A1097277 AI144126 A1080051 AA983529 AA860507 N53469 AA843767 N81163 N70628 AA424577 AA983537 8F003004 AA626688 AA235977 A1057152 A1095366 A1095356 AA458646 AW194479 AAt 50439 A1375272 AW571777 Ai359198 AA993793 BE614394 BE738239 AA127883 A1034344 T59504 D81608 AA908704 AW051665 AA382785 AA307208 N24639 A1370715 BE244980 AA548596 AW449675 Api191008 BF223749 N70752 N22266 Al191012 M028001 Al419106 BF215661 BF591548 BG942356 A1474968 BE858217 BF793358 AV756758 BG483603 A1093724 BF693395 BG545345 AI744294 T59549 AA811773 BG499757 444207 91723 BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA169357 BE932464 AA514889 AW819039 AW819083 BE843048 Al432496 Api470335 Api247243 BG533994 AA513783 At887309 AA528036 AW972006 AW873028 At924914 Al818810 AW152378 AW084946 Al521413 Al669583 BE932521 Al581370 BE180238 AW089750 AW771461 AW089714 Al590949 Al819148 M731056 BF815234 BF911506 AA235803 AA485373 Al735658 AW393133 AW073080 Api707637 BF353320 BE843111 AW819036 AW393135 BG697291 AV648670 AV654332 AV687530 BG566964 Api807430 Al676072 M837010 Al452482 Al625817 AW241750 BE048616 A1290928 A1680714 AA485530 BE175687 AV648513 AW130312 A1000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345 AI244948 AA602956 AA483492 AA918178 AW802049 BG675859 AV658871 BG678060A1565004AW819026 BE843092 AV686437 AV723049 BG616948 AI911647 AI743490 A1091096 BE857251 AI962074 AA040027 AW7693t 7

AA343477 AA640112 BF876213 R82948 H26425 H82876 BE843095 BE843140 BG536641 BG617830 AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996 A1749532 BE768614 BE857252 BE932516 BE768573 AV657993 AV657777 AV752631 BE774974 T55847 BF095761 BF911511 BE710793 BE180119 BG617338 H45942 T55897 AV657718 BG563497 450515 13638_2 BE299605 Al589870 M847598 Al470122 BF939896AI304356 BE223045 BF435800 Al394207 Al708171 AW025415 Ait9409 AW008420 AW304226 N34543 AW603578 AA526961 AA983631 N99134 AA626645 R45023 AA902417 AW672925 AA449985 AA953982 AW675471 AA010062 N80194 H14620 H28475 H26247 BF333581 AW842369 H06848 H05608 H81745 H15016 R51905 AA860423 AI860904 AA876023 406782 0 0 AA430373 AA968771 426143 3806 1 BC005265 BG176720 AW006027 BM352064 AW026316 AI635822 AI880584 AI693769 A1092211 BI492387 AI400449 AW166297 BF939910 AA232282 AW021432 Al333893 AA494308 AA854899 A1436795 AW069256 AA682373 A1092748 AA993184 Al 126077 A1081758 A1240686 A1261863 A1378423 AA465237 AI376096 AA035579 A1087306 AA448162 AA129977 A1090903 A1080686 A1288939 N33004 Api801240 AW021546 Al370773 Al086064 AA669528 A1250053 A1870113 AA853181 AA858014 BG055562 BG939559 AW080765 AA032283 AW467587 H40506 D00762 NM002788 AA641134 AI582295 AI417525 AI563975 A1093566 AI707743 AI290741 AW073417 BE875418 BM264076 BG876884 AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569 BG878291 BG876450 AW819099 Al908570 M449871 AU135228 BM478404 BFt 26296 AA375499 AA248473 400223 2368 1 NM 005648 BC013809 L34587 BF103775 BG702618 BG716553 Bl667090 BG505863 BF983483 BG718195 Bol857891 BG501016 BM043599 AL521812 BG705730 Bl495545 Bl495546 BF112248 BM023182 BM023123 A1075173 AW051799 BF058224 Bl324885BF436008 M398446 BG822375 BM019558 BM023382 BG164174 N56909 Bol467064 BM023464 A1207475 BM311415 BG758430 BG758807 Api934826 N90351 BG422026 BE910312 Al027778 Al081950AI360890 BM009115AI191829 BG759697 AI138728 AA399403 AI355589 AI336427 AA868702 AA393660 AA025127 BG027630 AA962774 AA631224 BG940967 BE791087M573315W81685M393525 BG944103AI339125AI149864M977655 N90314 BE612839 BG491847 A [129091 AA461234 AA781198 AA759256 AA888954 AA975B44 A1184099AI018025 AA398363 A1003331 A1193380 AA626020 A1244476 A1601114 AW135664 AI206607 AW263599 AA813219 AI684453 AA878626 AA772222 A1085496 AI630226 BG940966 A1022010 AA770649 AA887624 AA491739 AA974295 BG530040 AA037091 AA019912 BI160457 H64512 BG503896 427239 20459 2 AL532360 BE794750 AA582906 A1015067 AW271034 BG271636 AW075177 AW071374 AI345565 Al307208 BE138953 BE049086 Al334881 AW075006 AW075181 AA464019 AW302733 AW075100 AW073433 AI802854 AI334909 A1802853 AI345036 A1348921 AI340734 AI307478 AI251289 AW302327 AW072520 AI312145 AW073656 AW072513 AW071289 A1307559 AA876186 T29587 Al307493 Al255068 Al252868 Al252839 AW074809 AI252926 AI252160 AI251662 AI251262 AI610913 AI270787 AI270156 A1252075 AW073469 AW072901 AW072496 AW071420 AI305762 AI254764 AI802837 AI251264 AW073049 AW071311 A1340643 8E138965 BE738502 AW073456 A1334733 A1054335 BEI 39260 A1054302 A1054060 A1054057 A1053722 A1289711 BE139228 AW470478 AW271039 AW302085 BE041872 AI254494 AI271496 AI252427 BF718773 BF718645 AW074866 BE857822 TABLE 56C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 404854 7143420 Plus 14260-14537 405506 6466489 Plus 80014-80401, 80593-81125 402474 7547175 Minus 53526-53628, 5575555920, 57530-57757 TABLE 57A : ABOUT 304 GENES UPREGULATED IN MELANOMA METASTASES RELATIVE TO NORMAL SKIN Table 57A lists about 304 genes upregulated in melanoma metastases relative to normal skin. Genes were selected from 59680 probesets on the EoslAhymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : 90th percentile of melanoma metastasis Als divided by the 90th percent of normal skin Als R2 : 90th percent of melanoma metastasis Als divided by the 90th percentage of normal skin Als, where the 15th percentle of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 422424 Api186431 Hs. 296638 prostate differentiation factor 18. 94 25. 00 438549 BE386801 Hs. 21858 trinucleotide repeat containing 3 17. 45 18. 47 417880 BE241595 Hs. 82848 selectnL (lymphocyteadhesionmolecule 14. 05 11. 15 452838 U65011 Hs. 30743 preferentially expressed antigen in mela 13. 91 15. 41 446619 AU076643 Hs. 313 secreted phosphoprotein (osteopontin. 13. 41 9. 73 426555 NMJM0372 Hs. 2053 tyrosinase (oculocutaneous albinism IA) 12. 24 7. 33 439310 AF086120 Hs. 102793 ESTs 10. 12 10. 80 414020 NM_002984 Hs. 75703 small inducible cytokine A4 (homologous 9. 74 10. 16 447210 AF035269 Hs. 17752 phosphatidylserine-specific phospholipas 9. 43 11. 69 414812 X72755 Hs. 77367 monokine induced by gamma interferon 9. 28 10. 97 430377 NM001922 Hs. 301865 dopachrometautomerase (dopachrome delta 9. 07 7. 96 426600 NM003378 Hs. 171014 VGF nerve growth factor inducible 9. 06 19. 93 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 8. 66 5. 87 418310 AA814100 Hs. 86693 ESTs 8. 65 6. 62 433447 U29195 Hs. 3281 neuronal pentraxin 11 8. 27 4. 68 430280 AA361258 Hs. 237868 interleukin 7 receptor 8. 01 6. 37 430822 AJ005371 Hs. 248017 glyceraldehyde-3-phosphate dehydrogenase 7. 80 6. 10 456373 BE247706 Hs. 89751 membrane-spanning 4-domains, subfamily A 7. 78 7. 60 415752 BE314524 Hs. 78776 putative transmembrane protein 7. 68 5. 41 419628 H67546 Hs. 49768 ESTs 7. 66 8. 96 417355 D13168 Hs. 82002 endothelin receptor type B 7. 56 4. 59 424321 W74048 Hs. 1765 lymphocyte-specific protein tyrosine kin 7. 48 5. 77 412228 AW503785 Hs. 73792 complementcomponent (3d/EpsteinBanrvi 7. 43 4. 93 436485 X59135 Hs. 156110 immunoglobulin kappa constant 7. 35 7. 98 414646 AA353776 Hs. 901 CD48 antigen (B-cell membrane protein) 6. 97 5. 06 422241 Y00062 Hs. 170121 protein tyrosine phosphatase, receptor t 6. 83 5. 20 429170 NM_001394 Hs. 2359 dual specificity phosphatase 4 6. 67 3. 77 417542 J04129 Hs. 82269 progestagen-associated endomehial prote 6. 67 15. 22

428398 A1249368 Hs. 98558 ESTs 6. 57 3. 60 408989 AW361666 Hs. 49500 KIAA0746 protein 6. 48 4. 93 4) 7022 NM014737 Hs. 60905 Ras association (RatGDS/AF-6) domain fam 6. 38 3. 65 449644 AW960707 Hs. 148324 ESTs 6. 35 5. 84 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 6. 30 7. 18 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vasodilat 6. 25 7. 21 420991 AW504814 Hs. 287379 Homo sapiens mRNA for FLJ00111 protein, 6. 25 5. 36 428227 AA321649 Hs. 2248 small inducible cytokine subfamily 8 (Cy 6. 18 6. 01 432828 AB042326 Hs. 287402 chondroi6n 4-sulfotransferase 6. 12 6. 51 449078 AK001256 Hs. 22975 KIAA1576 protein 6. 05 8. 55 436856 A1469355 Hs. 127310 ESTs 6. 00 5. 54 433658 L03678 Hs. 156110 immunoglobulin kappa constant 5. 92 7. 18 424247 X14008 Hs. 234734 lysozyme (renal amyloidosis) 5. 89 4. 07 409417 AA156247 Hs. 104879 serine (orcysteine) proteinaseinhibito 5. 86 6. 07 431574 AW572659 Hs. 261373 hypothetical protein dJ434014. 3 5. 74 6. 03 458079 A1796870 Hs. 54277 DNA segment on chromosome X (unique} 992 5. 72 5. 92 440274 R24595 Hs. 7122 scrapie responsive protein 1 5. 69 3. 22 429412 Nom-006235 Hs. 2407 POU domain, class 2, associating factor 5. 69 5. 17 432606 NM 002104 Hs. 3066 granzyme K (serine protease, granzyme 3 ; 5. 68 3. 35 436315 BE390513 Hs. 27935 hypothetical protein MGC4837 5. 67 4. 56 452973 H88409 Hs. 40527 ESTs 5. 63 5. 50 426559 A8001914 Hs. 170414 paired basic amino acid cleaving system 5. 62 3. 09 406663 U24683 immunoglobulin heavy constant mu 5. 54 9. 68 416975 NM 004131 Hs. 1051 granzyme B (granzyme 2, cytotoxic T-hymp 5. 52 6. 42 408380 AF123050 Hs. 44532 diubiquitin 5. 51 4. 49 418299 AA279530 Hs. 83968 integrin, beta 2 (anGgen CD18 (p95), ly 5. 43 4. 50 429500 X78565 Hs. 289114 hexabrachion (tenascin C, cytotactn) 5. 42 3. 54 446341 AL040763 Hs. 310735 ESTs, Moderately similar to ALU7 HUMAN A 5. 41 5. 29 425234 AW152225 Hs. 165909 ESTs, Weakly similar to 138022 hypothev 5. 40 4. 35 434203 BE262677 Hs. 283558 hypothetical protein PR01855 5. 38 4. 16 420338 AA825595 Hs. 88269 Homo sapiens, clone MGC : 17339, mRNA, com 5. 37 5. 77 430580 AA806105 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 5. 31 5. 32 428804 AK000713 Hs. 193736 hypothetical protein FLJ20706 5. 29 4. 80 447735 AA775268 Hs. 6127 Homo sapiens cDNA : FLJ23020 fis, clone L 5. 29 3. 61 410491 AA465131 Hs. 64001 Homo sapiens clone 25218 mRNA sequence 5. 27 5. 35 410361 BE391804 Hs. 62661 guanylate binding protein 1, interferon-5. 26 6. 00 412561 NM002286 Hs. 74011 Iymphocyte-æ6va60ngene3 5. 26 5. 04 450293 N36754 Hs. 171118 hypothetical protein FU00026 5. 23 3. 60 400750 Target Exon 5. 18 3. 62 417933 X02308 Hs. 82962 thymidylate synthetase 5. 14 3. 33 413385 M34455 Hs. 840 indoleamine-pyrrole 2, 3 dioxygenase 5. 12 5. 36 445784 A1253155 Hs. 146065 ESTs 5. 12 4. 06 420602 AF060877 Hs. 99236 regulator of Gprotein signalling 20 5. 06 7. 68 421508 Nom-004833 Hs. 105115 absent in melanoma 2 5. 03 5. 59 434826 AF155661 Hs. 22265 pyruvate dehydrogenase phosphatase 4. 96 6. 25 402474 NM004079 : Homo sapiens cathepsin S (CTSS 4. 95 5. 13 400417 X72475 Target 4. 90 3. 93 420137 AA306478 Hs. 95327 CD3D antigen, delta polypeptide (TiT3 co 4. 88 6. 81 409264 Nu-014937 Hs. 52463 KIAA0966 protein 4. 88 3. 18 418460 M26315 Hs. 85258 CD8 antigen, alpha polypeptide (p32) 4. 87 4. 20 418506 AA084248 Hs. 85339 G protein-coupled receptor 39 4. 85 5. 86 409142 AL136877 Hs. 50758 SMC4 (structuralmånlenanceofchromoso 4. 83 5. 94 425088 AA663372 Hs. 169395 hypothetical protein FLJ12015 4. 82 5. 19 405506 Target Exon 4. 74 4. 09 409512 AW979187 Hs. 293591 melanoma differentiation associated prot 4. 74 3. 72 430838 N46664 Hs. 169395 hypothetical protein FLJ12015 4. 73 3. 50 439963 AW247529 Hs. 6793 ptatetet-activating factor acetylhydrola 4. 72 3. 66 421379 Y15221 Hs. 103982 small inducible cytokine subfamily 8 (Cy 4. 71 5. 16 447217 BE465754 Hs. 17778 neuropilin 2 4. 70 4. 52 422309 U79745 Hs. 114924 solutecartierfamily 16 (monocarboxylic 4. 69 3. 51 413670 AB000115 Hs. 75470 hypothetical protein, expressed in osteo 4. 68 3. 69 419956 AL137939 Hs. 40096 cadherin 19, type 2 4. 68 5. 83 429903 AL134197 Hs. 93597 cyclin-dependentkinaeS, egulatorysu 4. 68 5. 29 449217 AA278536 Hs. 23262 ribonuclease, RNase Afamily, k6 4. 66 3. 84 449722 BE280074 Hs. 23960 cyclic but 4. 64 4. 29 424006 AF054815 Hs. 137548 CD84 antigen (leukocyte antigen) 4. 62 4. 54 407846 AA426202 Hs. 40403 Cbp/p300-interactingtransactivator, wit 4. 62 6. 78 414821 M63835 Hs. 77424 Fc fragment of IgG, high affinity la, re 4. 59 5. 81 406673 M34996 Hs. 198253 major histocompabbility complex, class 4. 57 5. 60 431620 AA126109 Hs. 264981 Z-S-oligoadenylatesynihetase2 (69-71 4. 56 4. 44 441224 AU076964 Hs. 7753 calumenin 4. 56 3. 75 442739 NM_007274 Hs. 8679 cytosolic acyl coenzyme A thioester hydr 4. 56 3. 22 444371 BE540274 Hs. 239 forkhead box M1 4. 53 5. 28 448719 AA033627 Hs. 21858 Tinudeotide repeat containing 3 4. 48 9. 08 420301 AA767526 Hs. 22030 paired box gene 5 (8cell lineage specif 4. 47 5. 61 430294 AI538226 Hs. 32976 guanine nucleotide binding protein 4 4. 43 4. 11 428513 BE220806 Hs. 184697 Homo sapiens clone 23785 mRNA sequence 4. 41 4. 43 446006 NM 04403 Hs. 13530 deafness, autosomal dominant 5 4. 39 3. 99 432485 N90866 Hs. 276770 CDW52 antigen (CAMPATH-1 antigen) 4. 38 5. 50 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic 4. 37 3. 25 421633 AF121860 Hs. 106260 sorting nexin 10 4. 36 6. 23 414829 M321568 Hs. 77436 pleckstnn 4. 35 2. 91 417166 AA431323 Hs. 42146 ESTs 4. 35 4. 08

448410 AK000227 Hs. 21126 hypothetical protein FLJ20220 4. 34 5. 35 419381 AB023420 Hs. 90093 heat shock 70kD protein 4 4. 34 3. 72 411305 BE241596 Hs. 69547 myelin basic protein 4. 32 4. 18 425289 AW139342 Hs. 155530 interferon, gamma-inducible protein 16 4. 28 2. 44 451099 R52795 Hs. 25954 interleukin 13 receptor, alpha 2 4. 27 4. 48 432642 BE297635 Hs. 3069 heat shock 70kD protein 9B (mortalin-2) 4. 25 2. 69 422282 AF019225 Hs. 114309 apolipoproteinL 4. 25 3. 75 433867 AK000596 Hs. 3618 hippoeafdn-fikel 4. 23 5. 13 415817 U88967 Hs. 78867 protein lyrosine phosphatase, receptor-t 4. 20 2. 15 438619 AB032773 TU12B1-TY protein 4, 19 3. 32 426317 AA312350 Hs. 169294 transcrip6on factor 7 (T-cell specific, 4. 16 5. 14 420208 BE276055 Hs. 95972 silver (mouse homolog) like 4. 16 5. 08 416602 NM 006159 Hs. 79389 Protein kinase C-binding protein NELL2 4. 16 2. 38 430770 AA765694 Hs. 123296 ESTs 4. 15 3. 67 424541 AW392551 Hs. 180559 ESTs, Weakly similar to A56194 thromboxa 4. 15 3. 98 427337 Z46223 Hs. 176663 Fc fragment of IgG, low affinity Illb, r 4. 14 3. 51 456760 AW961251 Hs. 127828 guanine nucleo6de binding protein (G pr 4. 14 4. 42 406868 AA505445 Hs. 300697 immunoglobulin heavy constant gamma 3 (G 4. 13 5. 07 420931 AF044197 Hs. 100431 small inducible cytokine B subfamily (Cy 4. 12 6. 43 410016 AA297977 Hs. 57907 small inducible cytokine subfamily A (Cy 4. 11 8. 73 452698 NM_001295 Hs. 301921 chemokine (C-C motif) receptor 1 4. 11 4. 48 444863 AW384082 Hs. 104879 serine (or cysteine) proteinase inhibito 4. 10 4. 78 435080 Ai831760 Hs. 155111 hypothetical protein FLJ14428 4. 07 2. 76 442711 AF151073 Hs. 8645 hypothetical protein 4. 06 3. 49 423605 AF047826 Hs. 129887 cadherin 19, bpe 2 4. 06 2. 42 409038 T97490 Hs. 50002 small inducible cytokine subfamily A (Cy 4. 05 3. 26 421712 AK000140 Hs. 107139 hypothetical protein 4. 02 7. 60 422283 AW411307 Hs. 114311 CDC45 (cell division cycle 45, S. cerevis 4. 00 3. 87 409415 AA579258 Hs. 6083 Homo sapiens cDNA : FLJ21028 fis, clone C 4. 00 5. 87 412719 AW016610 Hs. 816 ESTs 3. 99 5. 46 437179 AA393508 serologically defined colon cancer antig 3. 96 4. 51 420319 AW406289 Hs. 96593 hypothetical protein 3. 95 5. 47 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 3. 91 4. 58 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur 3. 84 4. 42 420286 Api796395 Hs. 111377 ESTs 3. 83 4. 56 410600 AW575742 ESTs, Moderately similar to S65657 alpha 3. 80 5. 70 410326 A1368909 Hs. 47650 ESTs 3. 76 4. 86 424779 AL046851 Hs. 153053 CD37 antigen 3. 70 8. 72 452194 A1694413 Ubiquitin-iikepnoteinFAT10 ? ? ?-diubiq 3. 69 6. 38 411027 AF072099 Hs. 67846 leukocyteimmunoglobulin-likereceptor, 3. 65 5. 40 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines 3. 65 4. 48 424153 AA451737 Hs. 141496 MAGE-like2 3. 64 5. 82 421666 AL035250 Hs. 1408 endothelin 3 3. 64 5. 52 429732 U20158 Hs. 2488 lymphocyte cytosolic protein 2 (SH2doma 3. 60 5. 56 422173 BE385828 Hs. 250619 phorbolin-like protein MDS019 (CEM15) 3. 59 4. 35 421563 NM 006433 Hs. 105806 granulysin 3. 49 7. 38 453837 AL138387 Hs. 256126 baculoviral IAP repeat-containing 7 (liv 3. 49 6. 13 424326 NM 014479 Hs. 145296 ADAMlikedisintegrinprotease, decysin 3. 48 4. 23 427247 AW504221 Hs. 174103 integrin, alphaL (an6genCD11A (p180), 3. 47 5. 38 408838 Al669535 Hs. 40369 ESTs 3. 45 4. 59 402829 C1002500 : gil6754254lreflNP_034610. 1l hea 3. 42 5. 01 418918 X07871 Hs. 89476 CD2 antigen (p50), sheep red blood cell 3. 42 8. 14 430594 AK000790 Hs. 246885 hypothetical protein FU20783 3. 40 4. 35 429714 BE561801 Hs. 2484 T-cell leukemiallymphoma 1A 3. 36 4. 84 414324 Y14768 Hs. 890 lymphotoxin beta (TNF superfamily, membe 3. 35 4. 45 421958 AA357185 Hs. 109918 rashomologgenefamily, memberH 3. 35 4. 28 428291 AA534009 Hs. 183487 interferon stimulated gene (20kD) 3. 34 5. 18 424687 J05070 Hs. 151738 matrix metattoproteinase 9 (gelaúnase B 3. 31 8. 00 451736 AW080356 Hs. 23889 ESTs, Weakly similar to ALU7 HUMAN ALU S 3. 29 4. 50 412790 NM_014767 Hs. 74583 KIAA0275 gene product 3. 28 5. 42 404854 Target Exon 3. 28 4. 28 400860 Target Exon 3. 26 4. 41 430413 AW842182 Hs. 241392 small inducible cytokine A5 (RANTES) 3. 24 5. 65 438209 AL120659 Hs. 6111 aryl-hydrocarbonreceptornucleartransl 3. 24 4. 35 422846 BE513934 Hs. 1583 neutrophil cytosolic factor 1 (47kD, chr 3. 24 4. 90 440065 W03476 Hs. 266331 hypothetical protein MGC4595 3. 20 6. 21 440704 M69241 Hs. 162 insulin-like growth factor binding prote 3. 20 4. 72 411088 BE247593 Hs. 145053 ESTs 3. 18 4. 20 447513 AW955776 Hs. 313500 ESTs, Moderately similar to ALU7 HUMAN A 3. 18 4. 68 413190 AA151802 Hs. 40368 adaptor-related protein complex 1, sigma 3. 15 4. 27 430017 AA263172 Hs. 35 protein tyrosine phosphatase, non-recept 3. 15 4. 28 406837 R70292 Hs. 156110 immunoglobulin kappa constant 3. 12 4. 09 409103 AF251237 Hs. 112208 XAGE-1 protein 3. 04 4. 04 425706 AW406678 Hs. 122559 hypothetical protein FLJ22570 3. 04 4. 28 447656 NM_003726 Hs. 19126 src kinase-associated phosphoprotein of 3. 03 4. 30 427792 M63928 Hs. 180841 tumor necrosis factor receptor superfami 3. 01 4. 82 402994 NM002463' : Homo sapiens myxovirus (influ 2. 99 5. 74 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 2. 97 5. 07 449523 Nom-000579 Hs. 54443 chemokine (C-C motif) receptor 5 2. 96 4. 15 439237 AW408158 Hs. 318893 ESTs, Weakly similar to A47582 B-cell gr 2. 96 5. 81 406621 X57809 Hs. 8997 immunoglobulin lambda locus 2. 93 7. 88 447131 Nom-004585 Hs. 17466 retinoic acid receptor responder (tazaro 2. 91 13. 22 426322 J05068 Hs. 2012 transcobalamin I (vitamin B12 binding pr 2. 90 8. 37

448275 BE514434 Hs. 20830 kinesin-like 2 2. 87 4. 15 423397 NM001838 Hs. 1652 chemokine (C-CmoUf) receptor7 2. 86 5. 53 406782 AA430373 gb : zw20f11. s1SoaresovarytumorNbHOTH 2. 81 4. 60 414915 NM 002462 Hs. 76391 myxovirus (influenza) resistance 1, homo 2. 80 5. 89 412819 T25829 Hs. 24048 FK506 binding protein precursor 2. 78 4. 90 432886 BE159028 Hs. 279704 chromatin accessibility complex 1 2. 76 4. 21 428380 NM 004271 Hs. 184018 MD-1, RP105-associated 2. 76 5. 15 408209 NM004454 Hs. 43697 ets variant gene 5 (ets-related molecule 2. 76 4. 30 416511 NM006762 Hs. 79356 Lysosomal-associated mul6spanning membr 2. 75 4. 13 422530 AW972300 Hs. 118110 bone marrow stromal cell anfigen 2 2. 74 5. 05 428746 AW503820 Hs. 192861 Spi-B transcription factor (Spi-1/PU. 1r 2. 73 9. 20 453953 AW408337 Hs. 36972 CD7 antigen (p41) 2. 72 4. 38 407241 M34516 gb : Human omega light chain protein 14. 1 2. 68 4. 07 437669 AI358105 Hs. 123164 ESTs, Weakly similar to match to ESTs AA 2. 66 4. 71 453779 N35187 Hs. 43388 28kD interferon responsive protein 2. 65 4. 31 432874 W94322 Hs. 279651 melanoma inhibitory activity 2. 64 4. 15 410129 BE244074 Hs. 58831 regutator of Fas-induced apoptosis 2. 62 7. 36 412926 AI879076 Hs. 75061 mærophagemynstoylatedaanine-richC 2. 62 4. 43 418739 AA310964 Hs. 88012 SHP2 interacting transmembrane adaptor 2. 61 5. 42 424825 AF207069 Hs. 153357 procollagen-lysine, 2-oxoglutarate 5-dio 2. 60 9. 69 417370 T28651 Hs. 82030 tryptophanyi-tRNAsynthetase 2. 60 5. 17 411358 R47479 Hs. 94761 KIAA1691 protein 2. 59 4. 01 425367 BE271188 Hs. 155975 protein tyrosine phosphatase, receptor t 2. 58 13. 24 426470 AA528794 Hs. 128644 ESTs 2. 54 4. 52 425535 AB007937 Hs. 158287 KIAA0468 gene product 2. 52 11. 31 431629 AU077025 Hs. 265827 interferon. alpha-inducible protein (clo 2. 50 7. 80 425722 A1659076 Hs. 97031 hypothetical protein MGC13047 2. 49 4. 25 438291 BE514605 Hs. 289092 Homo sapiens cDNA : FLJ22380 fis, clone H 2. 49 4. 04 416426 AA180256 Hs. 210473 Homo sapiens cDNA FLJ 14872 fis, clone PL 2. 48 4. 08 441859 AW194364 Hs. 94814 ESTs, Weakly similar to FIG1 MOUSE FIG-1 2. 48 5. 25 416714 AF283770 Hs. 79630 CD79A antigen (immunoglobulin-associated 2. 48 4. 88 431186 NM_012249 Hs. 250697 ras-like protein 2. 46 6. 04 417389 BE260964 Hs. 82045 midkine (neurite growth-promoting factor 2. 45 5. 34 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 2. 43 6. 57 428437 AV656017 Hs. 184325 CGI-76 protein 2. 42 4. 96 427634 A1399745 Hs. 18449 hypothetical protein MGC10820 2. 39 8. 46 420842 A1083668 Hs. 50601 hypothetical protein MGC10986 2. 38 5. 90 428289 M26301 Hs. 2253 complement component 2 2. 38 5. 32 417929 R27219 Hs. 74647 Human T-cell receptor active alpha-chain 2. 37 6. 99 413278 BE563085 Hs. 833 interferon-stmulated protein, 15 kDa 2. 34 9. 69 433671 AW138797 Hs. 132906 19A24 protein 2. 34 4. 81 432403 AA550815 Hs. 124840 ESTs 2. 34 4. 99 427759 BE245578 Hs. 2200 perforin 1 (pore forming protein) 2. 32 4. 56 419870 AW403911 Hs. 266175 phosphoprotein associated with GEMs 2. 30 4. 22 421445 AA913059 Hs. 104433 Homo sapiens, clone IMAGE : 4054868, mRNA 2. 30 6. 18 401591 Target Exon 229 7. 01 451708 A1306536 Hs. 60975 ESTs 2. 26 4. 50 452700 A1859390 Hs. 288940 five-span transmembrane protein M83 2. 24 4. 90 424618 L29472 Hs. 1802 majorhistocompatibilibcomplex, clas 2. 22 5. 40 409208 Y00093 integrin, alpha (an6genCD11C (p150), 2. 21 4. 74 436456 AW292677 Hs. 248122 G protein-coupled receptor 24 2. 19 4. 61 419741 NMJM7019 Hs. 93002 ubiquitin carrier protein E2-C 2. 17 7. 43 416448 L13210 Hs. 79339 iectin. galactoside-binding. soluble, 3 2. 16 5. 58 438555 A1222089 Hs. 143878 Homo sapiens mRNA for FLJ00024 protein, 2. 13 4. 26 407260 L09095 gb : Hon) o sapiens MRNA fragment 2. 13 4. 00 448243 AW369771 integrin, beta 8 2. 10 4. 03 437938 A1950087 gb : wqO5c02. x1 NCl_CGAP_Kid12Homosapien 2. 07 4. 45 425262 D87119 Hs. 155418 GS3955 protein 2. 06 4. 36 414945 BE076358 Hs. 77667 Iymphocytean6gen6complex, 10cusE 2. 05 4. 66 400261 Eos Control 2. 04 4. 22 432468 AW402155 Hs. 3003 CD3E antigen, epsilon polypeptide (TiT3 2. 02 4. 23 416967 BE616731 Hs. 80645 interferon regulatory factor 1 1. 99 4. 45 420626 AF043722 Hs. 99491 RAS guanyl releasing protein 2 (calcium 1. 98 4. 42 440672 AF083811 Hs. 7345 MAD1 (mitotic arrest deficient, yeast, h 1. 98 4. 55 452923 BE276018 Hs. 288940 five-span transmembrane protein M83 1. 96 4. 54 452244 N33530 Hs. 176674 ESTs 1. 95 4. 23 427239 BE270447 ubiquitin carrier protein 1. 94 4. 93 418678 Nom 001327 Hs. 167379 cancer/testis antigen (NY-ESO-1) 1. 94 5. 28 431836 AF178532 Hs. 271411 beta-site APP-cleaving enzyme 2 1. 93 4. 17 444090 S69115 Hs. 10306 natural killer cell group 7 sequence 1. 93 5. 06 404067 Target Exon 1. 92 6. 16 426890 AA393167 Hs. 41294 ESTs 1. 91 4. 23 453597 BE281130 Hs. 33713 myo-inositol1-phosphatesynthaseA1 1. 91 4. 10 401914 Target Exon 1. 87 4. 76 448499 BE613280 Hs. 77550 hypothetical protein MGC1780 1. 87 5. 17 439627 BE621702 Hs. 29076 hypothetical protein FU21841 1. 85 6. 59 425923 NM_005026 Hs, 162808 phosphoinositide3-kinase, catalytic, de 1. 85 4. 03 416819 U77735 Hs. 80205 pim-2oncogene 1. 84 4. 57 425069 AA687465 Hs. 298184 potassium voltage-gated channel, shaker-1. 84 6. 40 430378 Z29572 Hs. 2556 tumor necrosis factor receptor superfami 1. 78 4. 02 435968 AW161481 Hs. 111577 integral membrane protein 3 1. 76 5. 26 410423 AW402432 Hs. 63489 protein tyrosine phosphatase, non-recept 1. 75 4. 30 434224 AA380731 Hs. 84 interleukin 2 receptor, gamma (severe co 1. 74 4. 91

413566 AW604451 Hs. 285814 sprouty (Drosophila) homolog 4 1. 71 6. 00 430148 BE387620 Hs. 234489 lactate dehydrogenase B 1. 70 4. 34 410068 Api633888 Hs. 58435 FYN-binding protein (FYB-120/130) 1. 69 4. 04 437696 Z83844 Hs. 5790 hypothetical protein dJ37E16. 5 1. 66 5. 95 423984 AF163825 Hs. 136713 pre-Blymphocytegene3 1. 64 6. 26 426666 AW500131 Hs. 171763 CD22 antigen 1. 63 4. 33 406908 Z25437 gb : H. sapiens protein-tyrosine kinase gen 1. 62 7. 19 440087 W28969 Hs. 7718 hypothetical protein FW22678 1. 61 4. 33 421859 AA356620 Hs. 108947 KIAA0050 gene product 1. 59 4. 30 415198 AW009480 Hs. 943 natural killer cell transcript 4 1. 56 4. 12 406827 AA971409 gb : op92c04. s1 NCl_CGAP_Lu5 Homo sapiens 1. 55 4. 29 413969 X14034 Hs. 75648 phospholipase C, gamma 2 (phosphatidylin 1. 53 4. 63 456086 AL161999 Hs. 77324 eukaryotic translation tertnination facto 1. 52 4. 11 433320 D60647 Hs. 250879 ESTs, Highly similar to CTXN RAT CORTEXI 1. 52 4. 36 406906 Z25424 gb : H. sapiens protein-serinelthreonine ki 1. 50 8. 67 406885 D28423 gb : Human mRNA for pre-mRNA splicing fact 1. 49 5. 07 443759 BE390832 Hs. 134729 FXYDdomån-containingiontransportreg 1. 48 4. 50 452423 AA991724 Hs. 180535 hypothetical protein MGC10966 1. 48 4. 91 448143 AF039704 Hs. 20478 ceroid-lipofuscinosis, neuronal 2, late 1. 43 4. 26 451524 AK001466 Hs. 26516 hypothetical protein FW10604 1. 43 4. 74 417287 A1831678 Hs. 285714 KIAA1599 protein 1. 41 4. 01 432665 AW603880 ATPase, H transporting, lysosomal (vacuo 1. 38 4. 07 403043 Target Exon 1. 36 4. 89 407239 AA076350 Hs. 67846 leukocyte immunoglobulin-like receptor, 1. 32 4. 57 436553 AW407157 Hs. 8997 immunoglobulin lambda locus 1. 30 4. 00 422934 BE244189 Hs. 122492 hypothetical protein 1. 30 4. 37 442680 BE270707 Hs. 8583 similar to APOBEC1 1. 26 4. 48 TABLE 57B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 438619 35124 1 NM 016575 A8032773 AI765521 BF593742 AI497757 AI761233 AW467938 BF000670 AI818496 N24761 AL043306 BF476138 BF593836 AA132787 Al147248 A1086795 AA151317 T95298 AW083548 AA058371 N27951 Al769860 AI784548 AW205506 AI800679 A1041733 AI459902 BE327641 A) 865829 A1254736 Ai302433 A1744176 A1241825AA027842 AL524933 AL524932 BF947764 BF340737 BF948700 BG996395 N53455 N21027 AI127616 N35901 AA682443 AA678249 AA719371 AA132582 T15981 H99958 N40717 AW959402 AI267251 BF909329 AI142035 T95379 H29420 R59632 H17318 H17331 H29327 R40829 R43395 R59573 A1749561 R56599 H16755 A1694500 AA027907 437179 12239 1 AK055109 BC019085 AA187684 BG656226 BM023227 Al932311 AW264381 AA398371 BM021483 Ai432433 A1375777 Al129580 AW262782 AA134107 BM023515 AA977504 AI859222 AI348454 R69725 AA975268 BM021207 AL080074 AA129218 AW207842 N90581 AA771919 A1092259 A1028416 A1074114 BG656536 BE501677 AW193419 AA917040 W90430 A1342984 A1378957 AL036486 AW020068 B1491093 BF476021 R41226 R69631 F04125 C02343 AA115589 R56480 A1400988 R54266 R31422 410600 497855_1 BF347859 AW499616 AA191322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 A1335824 AW408712 BM149172 452194 90339 1 Al694413 AW994700 Ai912946 N73548 A1082035 AW271652 W24189 W24182 AI719718 AA024658 AW810120 AW015394 T79755 AA988043 A1709339 406782 0 0 AA430373 AA968771 409208 10117_2 AK074047 Al144342AW014280 BM145128 N28267 AW206231 AA989041 H93197 AW5943 BG236296 AW236606 AW081031 AA765843 BM144372 AA989341 A1824838 Al963970 Al837671 AW196330 BG427526 BM148789 BF893644 BF881946 448243 13061_2 BG166513M479726 BE622314 AL134913 BE006305 BE006312 BE006298 AA044582 AW994956 AA234175 AA043906 BE006303 BF327669 BE006317 BF326759 BF541959 437938 66997 1 U71456 AA482911 W78802 AW856538 BF737212 N36809 N35320 AA282915 AW505512 A1653832 W87891 A1961530 T85904 H59397 R97278 W01059 A1820532 T82391 Ai820501 T63226 R66056 R67840 AW961101 AA337499 W37181 AA180009 AW205862 AA988777 AA856975 BF172457 BG751124 Al741346AI950344AI689062AI872193 AW102898 AW173586 Al763273 Al890387 AW150329 Al762688M488892AI356394 Al539642 AA642789 Al950087 BF589902 N70208 AA283144 AA488964 H60052 R97040 BF886630 AW967677 AW971573 AW967671 AI308119 AA251875 AA908598 AI819225 AI564269 AA908741 AA293273 AA969759 AW276905 M044209 H83488 T92487 400261 23110_1 BC006097 X03066 NM_002120 M26040 AW469119 AW469127 AI299772 AW518149 Al144456AW628070 Al629032AI358810 Al880433 Al440472 Al357070 Al865365 AW014799 A1767973 AW518041 AA909398 AW768606 427239 20459 2 AL532360 BE794750 AA582906 AI015067 AW271034 BG271636 AW075177 AW071374 AI3A5565 AI307208 BE138953 BE049086 AI334881 AW075006 AW0751 Bt AA464019 AW302733 AW075100 AW073433 Al802854 Al334909 Al802853 Al345036 Al348921 Al340734 Al307478 Al251289 AW302327 AW072520 AI312145 AW073656 AW072513 AW071289 AI307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 A1252926 A1252160 Al251662 Al251262 Al610913 Al270787 Al270156 Al252075 AW073469 AW072901 AW072496 AW071420 A1305762 A1254764 Al802837 Al251264 AW073049 AW071311 Al340643 BE138965 BE138502 AW073456 AI334733 A1054335 BE139260 A1054302 AI054060 A1054057 A1053722 Api289711 BE139228 AW470478 AW271039 AW302085 BE041872 Al254494 Al271496 Al252427 BF718773 BF718645 AW074866 BE857822 406827 0_0 AA971409 432665 27095_3 BG165971 BE143233 AL577712 AI400326 AA769318 AA427866 AW088714 AI150755 AI924874 AI186243 AA804195 AA768972 AW574769 AW341643 AW204520 AA235326 A1005076 8E826687 AW004816 AW007235 BE826639 BE826634 BF222941 BE826631 BE826643 AA292639 AW514133 A1690331 A1673409 AA627727 A1923685 AA931499 A1249783 Ai810663 AA548622 AA702095 AA832395 Bt259508 AA262993 AW075840 AA810885 TABLE 57C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et 21.'refers to the publication entitled The DNA sequence of human chromosome 22 Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 400750 8119067 Plus 198991-199168, 199316-199548 402474 7547175 Minus 53526-53628, 5575555920, 57530-57757 405506 6466489 Plus 80014-80401, 80593-81125 402829 8918414 Plus 101532-101852, 102006-102263 404854 7143420 Plus 14260-14537

400860 9757499 Minus 151830-152104. 152649-152744 402994 2996643 Minus 4727-4969 401591 9966977 Minus 55410-55835 404067 3282162 Plus 1415-2071 401914 9369520 Plus 62537-62945, 63155-63308 403043 7768753 Minus 314423-316252 TABLE 58A : ABOUT 183 GENES UPREGULATED IN MELANOMA METASTASES FROM PATIENTS WITH LIMITED DISEASE RELATIVE TO MELANOMA METASTASES FROM PATIENTS WITH PROGRESSIVE DISEASE Table 53A lists about 183 genes upregulated in melanoma metastases from patients with limited disease relative to melanoma metastases from patients with progressive disease. Genes were selected from 59680 probesets on the Eos/Ahymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : 90th percent of Als for metastases from patients with limited disease divided by 90th percent of Als for metastases from patients with progressive disease R2 : 90th percent'te of Als for metastases from patients with limited disease divided by 90th percentile of Als for metastases from patients with progressive disease, where the 15th percentile of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 415668 AW957684 Hs. 306814 hypothetical protein FU21889 12. 74 12. 92 447414 D82343 Hs. 74376 neuroblastoma (nerve tissue) protein 7. 66 5. 88 412659 AW753865 Hs. 74376 olfactomedin related ER localized protei 7. 23 5. 76 430154 AW583058 Hs. 234726 serine (or cysteine) proteinase inhibito 6. 91 14. 26 414430 A ! 346201 Hs. 76118 ubiqui6n carboxyl-terminal esterase Lt 6. 86 7. 10 436485 X59135 Hs. 156110 immunoglobulin kappa constant 6. 85 6. 81 426600 NM 003378 Hs. 171014 VGF nerve growth factor inducible 6. 73 11. 21 430822 AJ005371 Hs. 248017 glyceraldehyde-3-phosphate dehydrogenase 5. 53 4. 63 416426 AA180256 Hs. 210473 Homo sapiens CDNA FU 14872 fis, clone PL 5. 48 7. 08 423858 AL137326 Hs. 133483 Homo sapiens mRNA : cDNA DKFZp434B0650 (f 5. 27 5. 94 433658 L03678 Hs. 1561 10 immunoglobulin kappa constant 4. 78 3. 07 452436 BE077546 Hs. 31447 ESTs, Moderately similar to A46010 X-lin 4. 68 3. 27 413916 N49813 Hs. 75615 apolipoprotein C-li 4. 62 4. 82 407825 NM006152 Hs. 40202 lymphoid-restricted membrane protein 4. 55 3. 12 406648 AA563730 Hs. 277477 major histocompa6bility complex, class 4. 31 4. 15 409060 Api815867 Hs. 50130 necdin (mouse) homolog 4. 23 3. 44 401941 Target Exon 3. 89 3. 19 447471 AF039843 Hs. 18676 sprouty (Drosophila) homolog 2 3. 88 2. 43 419628 H67546 Hs. 49768 ESTs 3. 66 4. 16 414863 AW131473 Hs. 106185 ral guanine nucleotide dissociation sdm 3. 63 2. 81 423416 NM_W4920 Hs. 128316 apoptosis-associated tyrosine kinase 3. 47 3. 06 400275 NM-006513* : Horrto sapiens seryl-tRNA synth 3. 47 3. 43 426283 NM003937 Hs. 169139 kynureninase (L-kynureninehydrolase) 3. 42 1. 96 442117 AW664964 Hs. 128899 ESTs ; hypothetical protein for IMAGE : 447 3. 41 2. 89 411763 AW862589 gb : QVO-CT0387-180300-167-a07CT0387Homo 3. 37 6. 31 402007 C18000503 : gil89221651reqNP-jD6OO8O. ll h 3. 34 3. 74 424775 AB014540 Hs. 153026 SWAP-70 protein 3. 30 2. 00 424036 AA770688 H2Ahistone family, member L 3. 30 3. 16 453464 Al884911 Hs. 32989 receptor (calcitonin) activity modifying 3. 30 5. 58 401739 NM005622* : Homo sapiens SA (rat hyperten 3. 30 3. 23 440274 R24595 Hs. 7122 scrapie responsive protein 1 3. 27 2. 47 413398 D21262 Hs. 75337 nucleolar and coiled-body phosphprotein 3. 26 2. 61 417165 R80137 Hs. 302738 HomosapienscDNA : FLJ21425 fis, clone C 3. 26 2. 58 418478 U38945 Hs. 1174 cyclin-dependent kinase inhibitor 2A (me 3. 14 4. 04 436965 Z11894 Hs. 156110 gb : H. sapiens rearranged mRNAforimmunog 3. 13 2. 38 453857 AL080235 Hs. 35861 DKFZP586E1621 protein 3. 13 2. 47 404405 Target Exon 3. 11 4. 69 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy 3. 11 2. 10 443247 BE614387 Hs. 333893 c-Myc target JP01 3. 10 2. 26 400417 X72475 Target 3. 08 2. 32 401512 NM_014080 Homo sapiens duå oxidase-like 3. 07 2. 87 423242 AL039402 Hs. 125783 DEME-6 protein 3. 06 2. 78 417501 AL041219 Hs. 82222 sema domain, immunoglobulin domain (1g), 3. 06 2. 81 451952 AL120173 Hs. 301663 ESTs 3. 05 2. 65 427419 NM_000200 Hs. 177888 histaUn 3 3. 05 4. 24 406663 U24683 immunoglobulin heavy constant mu 3. 05 4. 55 442104 L20971 Hs. 188 phosphodiesterase 4B, cAMP-specific (dun 3. 03 1. 90 451993 AA765776 Hs. 122983 ESTs 3. 02 1. 71 421097 Api280112 Hs. 125232 Homo sapiens CDNA FU 13266 fis, clone OV 3. 01 3. 11 430129 BE301708 Hs. 233955 hypothetical protein Full20401 3. 00 3. 47 427700 AA262294 Hs. 180383 dual specificity phosphatase 6 3. 00 2. 22 400237 NM001087' : Homo sapiens angio-associated 2. 98 3. 43 414063 H26904 Hs. 75736 apolipoprotein D 2. 97 5. 76 426153 AF057169 Hs. 182771 vitelliform macular dystrophy (Best dise 2. 94 2. 38 414781 D50917 Hs. 77293 KIAA0127 gene product 2. 94 2. 88 445823 A1478563 Hs. 145519 FKSG87 protein 2. 92 1. 98 404439 ENSP00000067222' : Mitochondnal 28S fibos 2. 92 2. 57 421218 Nom-000499 Hs. 72912 cytochrome P450, subfamily I (aromatic c 2. 90 2. 47 420350 AW406896 Hs. 88269 Homo sapiens, clone MGC : 17339, mRNA, com 2. 90 3. 87 424855 AW204725 Hs. 25560 ESTs 2. 89 2. 61 436700 A1693690 Hs. 301406 hypothetical protein PP3501 2. 88 3. 63

451131 Api267586 Hs. 268012 fatty-acid-Coenzyme A ligase, long-chain 2. 87 2. 92 427157 U51166 Hs. 173824 thymine-DNA glycosylase 2. 87 2. 11 402273 Target Exon 2. 87 2. 48 414135 NM004419 Hs. 2128 dual specificity phosphatase 5 2. 83 3. 09 430643 AW970065 Hs. 287425 MEGF10 protein 2. 83 3. 04 451979 F06972 Hs. 27372 endothelial tyrosine kinase (Elk) (BMX), 2. 82 2. 12 406642 AJ245210 gb : Homo sapiens mRNA for immunoglobulin 2. 81 2. 88 407360 X13075 gb : Human 2a12 mRNA for kappa-immunoglobu 2. 81 3. 43 405441 Target Exon 2. 80 3. 15 450816 BE271927 Hs. 87385 ESTs 2. 80 2. 48 435675 AA694099 Hs. 266820 ESTs 2. 78 2. 70 426495 NM 001151 Hs. 2043 solutecanierfamily25 (mitochondnå 2. 78 2. 53 441623 AA315805 desmoglein 2 2. 78 2. 27 413336 Api569936 Hs. 296178 hypothetical protein FLJ22637 2. 76 3. 18 408527 AL135018 Hs. 33074 Homo sapiens, clone IMAGE : 3606519, mRNA, 2. 76 1. 92 437740 AA810265 Hs. 122915 ESTs 2. 76 1. 88 426322 J05068 Hs. 2012 transcobalamin I (vitamin B12 binding pr 2. 75 8. 06 411852 AA528140 Hs. 107515 ESTs, Weakly similar to T00329 hypotheti 2. 74 3. 30 428422 A1557280 Hs. 184270 capping protein (acbn filament) muscle 2. 73 Z31 426793 X89887 Hs. 172350 HIR (histone cell cycle regulation defec 2. 72 2. 19 401454 NM 014226-: Homosapiensenatumoranú 2. 72 1. 99 436825 AW341123 Hs. 120275 ESTs 2. 72 2. 89 407705 AB023139 Hs. 37892 KIAA0922 protein 2. 72 2. 48 416782 L35035 Hs. 79886 ribose Sphosphate isomerase A (ribose 5 2. 72 2. 63 449151 A1632331 Hs. 196038 ESTs 2. 72 2. 99 433464 N92481 gb : zb12g02. s1 Soares_fetal_iung_NbHL19W 2. 69 3. 17 401009 Target Exon 2. 69 3. 28 427227 AF103803 Hs. 283690 hypothetical protein 2. 68 2. 02 405268 ENSP00000223174' : KIAA0783 PROTEIN. 2. 67 2. 18 410295 AA741357 nidogen (enac6n) 2. 65 2. 06 435905 AW997484 Hs. 5003 KIAA0456 protein 2. 65 2. 12 430378 Z29572 Hs. 2556 tumor necrosis factor receptor superfami 2. 65 2. 52 457423 AK000642 Hs. 265018 hypothetical protein FU20635 2. 64 2. 51 448752 AA593867 Hs. 300842 KIAA1608 protein 2. 63 2. 20 414931 AK000342 Hs. 77646 Homo sapiens mRNA : cDNA DKFZp761M0223 (f 2. 63 1. 83 441283 AA927670 Hs. 131704 ESTs 2. 62 1. 92 439352 BE614347 Hs. 169615 hypothetical protein FU20989 2. 60 2. 21 421391 AW304350 Hs. 191958 immunoglobulin superfamily receptor tran 2. 60 3. 06 406678 U77534 gb : Human clone 1A11 immunoglobulin varia 2. 54 3. 06 430278 A1673074 Hs. 116567 ESTs, WeaNy similar to T22914 hypotheb 2. 49 3. 44 425970 AK001500 Hs. 165186 hypothetical protein FLJ13852 2. 47 3. 46 407363 AF035032 Hs. 8997 gb : HomosapienscloneMCA1Lmyosin-eæt 2. 45 3. 45 408367 AK001178 Hs. 44424 homolog of rat orphan transporter v7-3 2. 44 3. 52 420103 AA382259 Hs. 95197 aldehyde dehydrogenase 1 family, member 2. 44 6. 15 418635 L11329 Hs. 1183 dual specificity phosphatase 2 2. 42 3. 92 451558 NM001089 Hs. 26630 ATP-bindingcasette, sub-familyA (ABC1 2. 41 3. 08 430354 AA954810 Hs. 239784 human homolog of Drosophila Scribble 2. 36 3. 99 405701 ENSP00000004954' : Adseverin (Scinderin). 2. 33 4. 25 433427 A1816449 Hs. 171889 cholinephosphotransferae 1 2. 30 3. 30 401965 CGI-148 protein 2. 29 3. 45 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 2. 23 4. 07 428142 NM 001308 Hs. 2246 carboxypep6dase N, polypeptide 1, SOkD 2. 19 3. 17 422103 AA984330 Hs. 111676 protein kinase H1 1 ; small stress protein 2. 18 4. 18 425746 NM001701 Hs. 159440 bile acid Coenzyme A : amino acid N-acylt 2. 12 3. 48 404835 NM018943' : Homo sapiens tubulin, alpha-t 2. 09 5. 72 401127 Target Exon 2. 09 4. 38 406161 Target Exon 2. 08 3. 22 421654 AW163267 Hs. 106469 suppressorofvar1 (S. cerevisiae) 3-like 2. 08 3. 03 406632 AB006838 gb : Homo sapiens mRNA for HRV Fab N31-VH, 2. 07 3. 25 447940 D86982 Hs. 20060 KIAA0229 protein 2. 05 4. 80 411773 NM006799 Hs. 72026 protease, serine, 21 (testisin) 2. 05 5. 33 413211 AW967107 Hs. 109274 hypothe6cal protein MGC4365 2. 02 4. 74 425722 A1659076 Hs. 97031 hypothetical protein MGC13047 2. 01 3. 76 437044 AL035864 Hs. 69517 differentialiy expressed in Fanconi's an 1. 96 5. 27 436420 AA443966 Hs. 31595 ESTs 1. 94 3. 68 414809 A1434699 Hs. 77356 transferrin receptor (p90, CD71) 1. 92 3. 88 423420 A1571364 Hs. 128382 HomosapiensmRNA : cDNADKFZp76111224 (f 1. 90 3. 63 427923 AW274357 Hs. 301406 hypothetical protein PP3501 1. 90 3. 04 406652 AW150304 Hs. 277477 major histocompatibiiitycomptex. dass 1. 88 3. 00 435624 AF218942 Hs. 24889 formin 2 1. 88 3. 54 436552 NM014038 Hs. 5216 HSPC028 protein 1. 86 3. 29 408204 AA454501 Hs. 43666 protein tyrosine phosphatase type IVA, m 1. 86 3. 78 402728 C1002541-: gil4758590lref ; NP W4249. 1lim 1. 86 3. 14 420932 AW374605 Hs. 11607 ESTs WeaklysimilartoT21697hypolheti 1. 84 4. 72 458559 AW028820 Hs. 283614 ESTs 1. 78 3. 06 400278 ENSP00000243264 : Dolichyl-diphosphooligos 1. 76 3. 55 425751 T19239 Hs. 1940 crystallin, alpha B 1. 76 5. 31 420737 L08096 Hs. 99899 CD70 ; tumor necrosis factor (ligand) s 1. 74 3. 00 410006 AW732308 Hs. 57783 eukaryotic translation initiation factor 1. 74 3. 79 454429 BE273437 Hs. 301406 hypothetical protein PP3501 1. 73 3. 57 426321 BE046490 Hs. 180677 zinc finger protein 162 1. 72 3. 27 402897 NM023068' : Homo sapiens sialoadhesin (SN 1. 69 3. 81 423639 AB037826 Hs. 130411 KIAA1405 protein 1. 67 3. 31

448848 AF131851 Hs. 22241 hypothetical protein 1. 65 4. 27 414420 AA043424 Hs. 76095 immediate early response 3 1. 60 3. 02 440747 AW297226 Hs. 137840 ESTs Moderately similar to SIX4 HUMAN H 1. 56 3. 28 450635 AW403954 Hs. 25237 mesenchymal stem cell protein DSCD75 1. 55 3. 73 400252 NM_004651' : Homo sapiens ubiquitin specif 1. 55 3. 26 411825 AK000334 hypothetical protein FLJ20327 1. 55 3. 18 414328 Z21666 Hs. 300463 aconitae2 mitochondrial 1. 52 4. 03 400263 Eos Control 1. 51 3. 42 421552 AF026692 Hs. 105700 secreted frizzled-related protein 4 1. 50 3. 19 436673 AF201931 Hs. 5268 hypothetical protein FLJ10479 1. 49 3. 33 404739 Target Exon 1. 49 3. 10 438344 BE387726 Hs. 343411 DEAD/H (Asp-Glu-AIa-Asp/His) box polypep 1. 46 3. 42 421696 AF035306 Hs. 106890 Homo sapiens clone 23771 mRNA sequence 1. 44 3. 15 425240 AA306495 Hs. 1869 phosphoglucomutase 1 1. 44 3. 04 412099 U64198 Hs. 73165 inteneukin 12 receptor, beta 2 1. 43 3. 71 434642 W25739 chromobox homolog 5 (Drosophila HPI alph 1. 42 3. 07 404406 Target Exon 1. 42 3. 87 433320 D60647 Hs. 250879 ESTs Highlysimila toCTXN RATCORTEXI 1. 41 3. 80 447697 W52125 tubulin alpha 1 1. 40 4. 45 415780 U75898 Hs. 78846 heat shock 27kD protein 2 1. 40 3. 28 447216 R75812 Hs. 169248 p75NTR-associatedseUdeathexecutor o 1. 39 3. 77 401772 NM014520 : Homo sapiens MYB binding prote 1. 39 3. 67 413031 BE515051 Hs. 75160 phosphofructokinae muscle 1. 38 3. 31 435604 AA625279 Hs. 26892 uncharacterized bone marrow protein BM04 1. 37 3. 17 428011 BE387514 Hs. 181418 KIAA0152 gene product 1. 37 3. 05 445580 AF167572 Hs. 12912 skb1 (S. pombe) homolog 1. 35 3. 11 436703 AW880614 Hs. 146381 RNA binding motif protein, X chromosome 1. 34 3. 05 438277 AL022326 Hs. 6139 synaptogyrin 1 1. 34 3. 09 451481 AA300228 Hs. 295866 hypothetical protein DKFZp434Nl923 1. 32 3. 23 421818 AW992976 Hs. 50098 NM002489 : Homo sapiens NADH dehydrogenas 1. 31 3. 01 412968 AW500508 Hs. 75102 alanyl-tRNA synthetase 1. 28 3. 58 452378 AA025855 Hs. 19597 KIAA1694 protein 1. 25 3. 08 447455 H38335 Hs. 6750 Homo sapiens mRNA for FU00058 protein, 1. 24 3. 45 402212 KIAA0430 gene product 1. 21 3. 03 428773 BE256238 Hs. 193163 bridging integrator 1 1. 20 3. 20 430067 U79458 Hs. 231840 WW domain binding protein 2 1. 18 3. 03 418289 AW403103 Hs. 83951 Hermansky-Pudlak syndrome 1. 17 3. 32 405752 Target Exon 1. 00 3. 40 422836 AL037365 Hs. 194093 AKAP-binding sperm protein ropporin 1. 00 3. 00 TABLE 58B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 400275 18707 1 NM 006513 BC009390 X91257 BC000716 8M450041 BI771139 AV710955 AU120415 AU141179 AU121081 8E409287 AU141397 AU122238 81256788 BE386217 AU143368 AU133780 AU139704 BG531086 BE268235 BE545230 AU143414 AV761720 AU129842 AU143343 BE270064 BG473378 BE298813 Bol772360 BE617354 AU140124 BE277005 BG746716 BE814960 AW161287 AV762084 BG898985 AW674875 AA313975 AV749916 AA374328 BM011248 AU098465 AW238888 BG940091 BG284599 AW410037 AA378483 D49914 AL573323 AL549819 AL572282 AL572871 AL568117 AL571945 AL547790 AL581217 AL514659 AL573926 AL540816 AW410038 B1262249 BG284713 A1659394 A1093582 AW965846 AA652206 A1686014 AA654357 AU146982 AW273447 AW157715 AW574750 BG683509 AW887824 Ai818522 AA703770 BE542873 AA515504 AU154982 AA831254 AA828521 AI088602 AA854654 AA190869 BF062816 AA464944 BG261335 A1003584 BG402820 AA932098 W68695 AW182900 W37334 A1073864 C17924 C18528 Al299318 BF154399 BG319570 BF764242 BF764209 Api620320 T06029 BF447193 F29285 AL548949 J333775 BE743602 BE618230 BE268139 BF036434 BE562718 BG774381 AA659833 AA297649 AA010945 BG105512 BE269205 T32623 BG015679 AL518518 AL517118 AL538396 Al049861 AL581976 AV752041 W26586 BE181609 A1963016 BG057603 A1720256 AA844560 AA055570 BE619606 C17428 A1042174 N93945 N69743 BF795208 AW057940 B1091399 AW975179 AA909936 H28712 W65445 AL515439 W37117 H66514 T85737 W37369 411763 1103041_1 AW862589 AW860959 424036 6226. 1 NM033445 BC001193 A1885781 BF794032 AA476620 AA810906 AA810905 A) 291244 At885097 A1359708 A1335629 H97396 A1344589 AA300377 AA457566 AW771833 BE465621 AI364068 AI364452 AI648505 AI918342 AI928670 AA886580 AL531029 AA886344 AI186419 BG329096 BM045465 AL531028 BG437151 BE868021 AA179427 400237 9484 1 BC014122 M95627 NM 001087 BC020244 BC008809 AL542809 AL522027 AL517616 AL539615 AL555640 AL546094 AL528959 AL555071 81858518 Bai600907 AU120890 BE257146AV707965 Bl911155 BG575776 BE302876 BE277469 BE389232 AL533354 BE389814 BG829179 BE384687 BE276341 BG746912 BG425149 AL047913 BE250277 BG116066 AW410799 BG478074 BG471558 BF813165 AA016192 BG334833 BE383857 AA218784 AL517615 B1822297 BE677910 AW169102 AW410800 AU144298 AI215124 AW275306 AU147438 BE205773 AI343920 AI972200 AA666173 AI568496 AA742466 A1075003 BE858669 81789274 BI964722 AI310312 A1928567 F28593 81962793 AA053407 AA603722 A1419246 AA705597 BF445723 AA441804 AA774757 BG152609 Al301244 BF058147 A1879460 At470194 D80510 AA923557 W69781 Ai301243 A1880348 AL517973 AL542808 BE300552 AA143563 AL567123 AA553412 AA547999 AW262497 AW027349 AW469464 BE300553 AI687352 BG222276 AU146833 AA847176 AA724639 A1868270 AL530431 A1583619 AL563298 B1857771 C00178 AW130086 A1312650 A1470187 AL577668 BF816236 BF815492 BE221500 W48859 T54102 AI828100 AW190156 AI961278 AL565165 BF966475 BM013215 BG109077 BF793617 AA381776 AA381486 BF916382 BE745391 AA330239 BG117939 BF337403 BG770295 AL567952 AL571817 BE832508 BF032720 406642 0_0 AJ245210AJ245212AJ245211 AJ245213 441623 3362_1 BC022413 BE395396 BF754175 AA506621 BE706665 BE706678 AA723159 BE153169 BE706729 BE706558 BE153312 BE706706 AW371853 AW371849 BE153241 BC017410 A1337912 A1090244 AW090300 BE219837 Ai623661 BE501576 BE501734 A1742232 A1023964 A1458424 AA975373 A1288904 A1984583 AA890325 N32562 AI358102 AW241694 A1038448 A1672071 A1018389 AA576391 AA977874 AW189392 W37448 AA612894 A1277548 H89551 A1699774 H89365 AA315805 AW579186 BC014584 BC014581 AW780125 A1672414 BE328145 AW600919 BF031306 AW172758 BE708322 AA345675 BE875779 H28241 H25318 BF540913 BG179688 BF110202 AA528775 W37573 BE041644 AW366504 BM129522 BM129822 Al122760 BE718200AW887496M149420 BE706307 BE539395 BE748765 AI373653 R75904 BF979185 BF691393 BG495595 81094458 BE706702 BG496559 BF248373 BG494800 433464 1015899_1 N92481 AW674508 AA593748 AW974058 A1475594 410295 2817_1 BG402852 BG545066 AA150252 AL036760 AA452480 A1033256 W68776 W93372 N31248 AI052219 AI367635 W69374 N88610 R58194 B1524854 B ! 497111 BF940043 AI129268 AI359798 A1056480 AA121421 A1042150 AW449003 AI4t8t80 AI419420 AI356058 BF832243 AI349330 AI359448 W76647 BF477170 AA099163 BF994549 AW608256 AA045418 H03770 AL574791 AW069455 BE302148 AW022281 AW960273 AAi 21268 AI336371

A1989381 ! 131425A ! 147483Ai311537AW338638A) 141649AA709414A) 187177AA780884Ai333805AA045312Ai6239t8Ai349421W63753 W70299 AA557276 AA299007 N98212 W74064 N24823 T54892 AA054724 W73059 A1869152 N93462 N71889 Al537432 R71628 AA303089 Api498550 T60941 AV706417 AW067848 Al 150677 AW3381 18 A1336313 AA826256 All 39518 AA662948 AA902723 A1970175 W68682 Al089380 Al148372 H99951 AW183001 A1270317 AA532767 AA044727 AA931652 R82469 AA150261 W67788 H67495 R80715 AW149812 N78914 Api862034 W61122 AW023118 W69375 T88917 T47984 N21531 R35646 AA055544 Ht 5534 AA688295 AA090586 AA044764 BF994641 R79547 N21313 BF674610 H02874 AW975323 R16904 AA328030 AA054671 R79546 BF832310 Api249109 406678 0_0 U77534 U77537 406632 0 0 AB006838 AB006837 A8006836 AB006834 A8006835 400278 170-I Y00281 NM_002950 BC010839 BC007995 BG675232 BM468552 AL555484 BG831516 BF035300 BG677277 BF852972 BE314901 BF850656 AI371816 AA292474 AA375747 AA308414 BM454544 Bol333370 BM049921 B1461428 B1465007 Bl223401 BE856245AW821164 BF914775 BF914761 AUI 25a35 B1222678 B1091137 BF340536 BM462798 81224452 BG707915 AL569160 AA443815 AW572867 AW363410 BF739268 BG010283 BiO13120 BF818845 BF763468 AA305165 Al630370 M039826 R24906 H02046 T96891 BF981330 AW936510 AA478169 H04587 BG166574 Bol869342 BE562482 BE539637 AA165089 AL579118 AL553699 BE044054 AW117440 AI520674 BF435417 AW245648 AI952404 T29534 AU153459 AU152168 AW591591 AU146918 M393187 M478013 AU148143 AI224471 AI640728 AI871537 AW264752 N93787 Api189357 AV756134 A1471659 AU147466AA779206AU149419AU149104AU159135AA312221AW445t19AW02 1912At799771F04407Ai285530Ai914643AW068751AA513325 AA164627AA639285AA569644T96892A [923594 BF4391BOB1770936BF032438AUi54884AA682793AW072992AU158815AI88 4444AL048031 AU158922 AU152546 Al695187 AL048033 Al245650 AU148507 AW467451 BE536868 BF913001 BF062707 AL573082 AW067993 M523354 BE886727 AI890705 AU159092 AI982693 AI817553 AA236729 AI687858 BG163767 AI524675 AI678155 AA127100 AI762661 AU159718 AI469720 AA483627 AW131696 R26868 AI199885 AW875614 AW938694 AW578974 BI763988 BG819168 BE874767 BG978292 BE162948 AL555483 AW189719 T56783 A1018819 AI476552 BI492837 AI824440 BG996262 AA932887 AI380726 R79530 AA622108 AI262575 T56782 R27437 BE784153 AW129549 Al675567 Al866759 BG987935 400252 26562 U44839 NM00465t BC000350 B1458316 AU1 7940 BG759024 BG749694 BE799505 BG831537 A1816335 AA325352 AL547005 AWI 57038 A1859331 Api816186 AU150786 AL043549AW162880 AU159233 M143169 T03478 BE727648 AA764725 BE206603 Al369814 Al98U69 AW157545 BE221486 H99016 AU159025 Al074496 Al494516 BE245950 AA704385 AA280862 A1479595 A1369776 BE671398 T05538 AA682249 BI677303 BE645335 Al359U4 H92868 D52599 D53609 D54715 T06015 BE222174 Al954706 D53218 D53787 R69889 W86896 A1497670 R70771 BF309414 BE620147 BG910597 AW964968 BE836120 AL579715 H56512 D55956 BI044097 AL555239 BF220278 AA081991 AI819544 AW001573 AW131600 AI858764 D52367 W22034 BG818979 BG024561 BE702779 B1458863 Bol910399 BG707755 BF348284 H10055 81086315 BE620574 H41088 BG119517 W23267 W21941 AA328817 411825 7891 1 AK000695 AK000489 BC001688 B235988 AW006329 AI887644 AI207230 AI148213 AI304333 AI634653 AW662636 AI281247 AA946921 AA424487 BE272330 A) 830588 AA159183 AA977141 BG231801 AA631793 AA975194 BF817537 AA47T798 B1906631 AW083424 AA625199 NM017767 AK000334 BF984048 AW815634 AL573992 AA430612 AA928390 AA464447 AW340827 AA424290 Al927759 BG951502AW881353 Bl765535 400263 18977_1 Z11692 X51466 NM 001961 M19997 BI224253 BG830478 AU122147 AU123437 8Gt 13591 BG752624 BE886804 81868669 BG337216 AW629935 BM016525 AI560409 AL562866 AI909178 BF849556 AA371735 BF038841 BF727115 BC006547 BG757526 AL555664 81261304 BG770095 B1033486 Bol517580 BG876486 81011828 AI313235 BG831724 Bof869862 BG998348 BI011834 BF888337 BF898627 BF092380 AW803215 F01241 BF805719 BG876487 AW498536 BF988866 BG998849 AA248724 BG829202 BG756456 BG032392 Bl859287 BM016990 BG332359 BE933685 BE166758 BM452445 AI937808 AW026128 N23684 AW006041 Ai337621 F33111 BF344301 BG105450 BG387343 BF569547 BF154671 BM007368 BF569385 BE772007 Bl199487 BF761700 81261519 BF944452 BF898506 A1038390 BM044934 AW381142 BG743618 BE769206 BE893973 81015047 BF886479 BF761350 BE769769 BG766117 BF847365 BE397834 AW371121 BF089125 BE082996 BF183193 BG180964 BF089940 B1000274 BG255503 BG674499 BG774174 Bol015084 434642 154611 AF147443 BM471094 AA948055 AA973157 AA284289 W25739 BiO21926 BF898367 W02720 BF798341 BF378312 AA427766 BG955568 BF899591 BF884215 447697 MH497_6 BE742621 AL528391 AA328484 W52125 AA321596 AA022458 AW971024 A1052029 A1761638 AA628498 BE619513 AA412069 A1027538 AW514954 A1884599 A1097362 A1499259 A1419408 AW469200 A1992152 A1142045 A1066572 A1275439 AA581877 A1347308 A1016726 All 27541 AW002064 Al 141786 AW051842 A1355329 Al 198198 A1347858 A1027870 A1039163 AA576695 Al 183286 A1362001 A1361994 AA594668 AA459257 AA745778 AI139667 F20651 AI201510 AA832171 BM464599 BM464574 AI972621 AI183887 AW131911 AW771584 BE619828 AA492218 AA025767 AA977354 AA385481 N45137 W73596 A1864400 A1200026 A1270953 F18139 W46301 H55825 A1039867 A1457570 AI928639 AI824685 A1083898 AW024570 AA285299 AW381097 AW582409 BE964181 TABLE 58C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et al.'refers to the publication entitled The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 401941 4982556 Plus 112022-112204 402007 7381786 Plus 143964-144081 401739 2982169 Plus 132194-132404 404405 7272262 Plus 83251-83415 401512 7622346 Plus 136399-136557 404439 7139680 Plus 55316-55585 402273 2979528 Plus 28990-29203, 32299-32402, 32474-32668 405441 7408124 Plus 100952-101283 401454 9186923 Minus 114659-114832 401009 8117391 Minus 83179-83304 405268 4156151 Minus 24404-24521 405701 4263751 Plus 93243-93364 401965 3126781 Minus 18239-18389, 19921-20076 404835 6970743 Plus 85462-85684, 88139-88287, 90338-91018, 9482 401127 8699701 Minus 88327-88458, 96150-96266 406161 7144954 Plus 16666-16836 402728 9211639 Plus 3192-35694267-4728 402897 8570339 Plus 6193g62241, 64304-64615, 65140-65391 404739 8217493 Plus 42742-43671 404406 7329316 Minus 47543-47928 401772 9966243 Plus 183917-184042 402212 7689783 Minus 69382-69936 405752 9212305 Plus 91392-91528 TABLE 59A : ABOUT 201 GENES UPREGULATED IN MELANOMA METASTASES FROM PATIENTS WITH PROGRESSIVE DISEASE RELATIVE TO MELANOMA METASTASES FROM PATIENTS WITH LIMITED DISEASE

Table 59A lists about 201 genes upregulated in melanoma metastases from patients with progressive disease relative to melanoma metastases from patients with limited disease. Genes were selected from 59680 probesets on the Eos/Affymetnx Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number Unigene) D : Unigene number Unigene Title : Unigene gene title R1 : 90th percenGle of Als for metastases from patients with progressive disease divided by the 90th percent of Als for metastases from patients with limited disease R2 : 90th percentage of Als for metastases from patients with progressive disease divided by the 90th percentage of Als for metastases from patients with limited disease, where the 15th percentile of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAcen UnigenelD Unigene Title R1 R2 422168 AA586894 Hs. 112408 S100 calcium-binding protein A7 (psorias 8. 58 13. 77 448966 AW372914 Hs. 86149 phosphoinositol 3 phosphate-binding pnot 7. 43 5. 91 440099 AL080058 Hs. 6909 DKFZP564G202 protein 7. 07 4. 56 431211 M86849 Hs. 323733 gap junction protein, beta 2, 26kD (conn 6. 91 3. 51 420859 AW468397 Hs. 100000 S100 calcium-binding protein A8 (calgran 6. 90 6. 44 418067 Al127958 Hs. 83393 cystatinE/M 6. 62 10. 34 422166 W72424 Hs. 112405 S100 calcium-binding protein A9 (calgran 6. 47 13. 26 409632 W74001 Hs. 55279 serine (orcysteine) proteinase inhibito 6. 25 3. 41 401780 NM_005557 : Homo sapiens keratin 16 (foca 6. 10 4. 24 437191 NM 006846 Hs. 331555 sedne protease inhibitor, Kazal type, 5 5. 97 6. 60 422511 AU076442 Hs. 117938 collæen, wpeXVll, alpha1 5. 89 3. 57 412636 NM 004415 desmoplakin (DPI, DPII) 5. 82 3. 51 417124 BE122762 Hs. 25338 ESTs 5. 16 3. 16 430686 NM 001942 Hs. 2633 desmoglein 1 5. 03 3. 57 421733 AL119671 Hs. 1420 fibroblast growth factor receptor 3 (ach 4. 84 4. 15 422192 AA305159 Hs. 113019 fus485 4. 79 4. 59 407366 AF026942 Hs. 17518 gb : Homo sapiens cig33 mRNA, partial sequ 4. 33 2. 37 429493 AL134708 Hs. 145998 ESTs 4. 28 4. 79 456525 AW468397 Hs. 100000 S100 calcium-binding protein AB (calgran 4. 23 4. 82 409010 Al648675 Homosapiens, SimilartoRIKENcDNA17W 4. 23 3. 69 410748 BE383816 Hs. 12532 chromosome 1 open reading frame 21 4. 11 2. 33 409760 AA302840 gb : EST10534 Adipose tissue, white I Homo 4. 06 3. 65 424670 W61215 Hs. 116651 epithelialV-likean6gen1 4. 02 4. 07 417366 BE185289 Hs. 1076 small proline-rich protein 18 (comifin) 3. 97 4. 71 418663 AK001100 Hs. 41690 desmocollin 3 3. 95 5. 08 402075 ENSP00000251056' : Plasma membrane calcium 3. 93 5. 85 428330 L22524 Hs. 2256 matrix metalloproteinase 7 (matrilysin. 3. 90 3. 19 427809 M26380 Hs. 180878 lipoprotein lipase 3. 87 3. 21 413859 AW992356 Hs. 8364 Homo sapiens pyruvate dehydrogenase kina 3. 85 5. 75 431048 R50253 Hs. 249129 cell death-inducing DFFA-like effector a 3. 80 3. 10 431369 BE184455 Hs. 251754 secetoryleukocyteproteaeinhibitor (3. 79 3. 36 421485 AA243499 Hs. 104800 hypothetical protein FU10134 3. 67 3. 35 429852 AB010445 Hs. 225948 small inducible cytokine subfamily A (Cy 3. 65 4. 14 418686 Z36830 Hs. 87268 annexin A8 3. 65 3. 62 448429 D17408 Hs. 21223 calponin 1, basic, smooth muscle 3. 64 3. 18 422963 M79141 Hs. 13234 ESTs 3. 60 4. 10 428874 W32133 Hs. 194366 transthyretin (prealbumin, amyloidosist 3. 58 3. 97 401785 NM002275' : Homo sapiens keratin 15 (KRT1 3. 58 5. 05 454117 BE410100 Hs. 40368 adaptor-related protein complex t, sigma 3. 56 1. 92 419329 AY007220 Hs. 288998 S100-type calcium binding protein A14 3. 54 5. 62 424012 AW368377 Hs. 137569 tumor protein 63 kDa with strong homolog 3. 53 4. 70 417515 L24203 Hs. 82237 ataxia-telangiectasia group D-associated 3. 52 8. 33 430376 AW292053 Hs. 12532 chromosome t open reading frame 21 3. 51 2. 32 454229 AW957744 Hs. 278469 lacrimal proline rich protein 3. 50 3. 12 401781 Target Exon 3. 45 3. 57 408000 L11690 Hs. 198689 bullous pemphigoid antigen 1 (230/240kD) 3. 45 5. 07 431567 N51357 Hs. 260855 HomosapienscDNA : FLJ21410 fis, clone C 3. 44 5. 03 419648 T73661 Hs. 91877 thyroid hormone responsive SPOT14 (rat) 3. 42 7. 72 414798 A1286323 Hs. 97411 hypothetical protein MGC12335 3. 41 2. 65 442315 AA173992 Hs. 7956 ESTs, ModeratelysimilartoZN91_HUMANZ 3. 41 5. 03 442498 U54617 Hs. 8364 Homo sapiens pyruvate dehydrogenase kina 3. 32 2. 86 410883 D43767 Hs. 66742 CCL17chemokine (TARC) (SCYA17) 3. 28 3. 18 418026 BE379727 Hs. 83213 fatty acid binding protein 4, adipocyte 3. 26 3. 10 453309 A1791809 Hs. 32949 defensin, beta 1 3. 24 3. 64 420783 A1659838 Hs. 99923 lectin, gatactoside-binding, soluble, 7 3. 21 3. 64 409601 AF237621 Hs. 80828 keratin 1 (epidermoly6c hyperkeratosis) 3. 19 4. 37 413163 Y00815 Hs. 75216 protein tyrosine phosphatase, receptor t 3. 16 5. 48 452101 T60298 Hs. 10844 Homo sapiens cDNA FU 14476 fis, clone MA 3. 15 3. 60 412633 AF001691 Hs. 74304 periplakin 3. 15 3. 98 407839 AA045144 Hs. 161566 ESTs 3. 15 4. 11 427318 AF186081 Hs. 175783 zinc transporter 3. 11 3. 58 427899 AA829286 Hs. 332053 serum amyloid A1 3. 10 3. 53 421948 L42583 Hs. 334309 keratin 6A 3. 08 2. 75 452744 A1267652 Hs. 246107 HomosapiensmRNA ; cDNADKFZp434E082 (fr 3. 05 2. 99 410001 AB041036 Hs. 57771 kallikrein 11 3. 04 3. 02 413435 X51405 Hs. 75360 carboxypeptidase E 3. 00 2. 40 428500 AI815395 Hs. 184641 fatty acid desaturase 2 2. 98 5. 22 410099 AA081630 KlMN36geneprodud 2. 97 2. 05 437679 NM 014214 Hs. 5753 inositol (myo)-1 (or 4)-monophosphatase 2 2. 93 3. 45 413835 A1272727 Hs. 249163 fatty acid hydroxylase 2. 93 4. 78

446068 AL049801 Hs. 13649 Novel human gene mapping to chomosome 13 2. 89 2. 93 450680 AF131784 Hs. 25318 Homo sapiens clone 25194 mRNA sequence 2. 88 3. 14 428398 Al249368 Hs. 98558 ESTs 2. 88 2. 05 417433 BE270266 Hs. 82128 5T4 oncofetai trophoblast glycoprotein 2. 86 2. 12 427919 AA173942 Hs. 326416 Homo sapiens mRNA ; cDNA DKFZp564H1916 (f 2. 84 2. 98 412676 NM 000165 Hs. 74471 gap junction protein, alpha 1, 43kD (con 2. 83 2. 82 428695 A1355647 Hs. 189999 purinergic receptor (family A group 5) 2. 83 2. 37 446989 AK001898 Hs. 16740 hypothetical protein FLJ11036 2. 82 2. 73 428471 X57348 Hs. 184510 stratifin 2. 79 3. 31 416305 AU076628 Hs. 79187 coxsackie virus and adenovirus receptor 2. 79 3. 72 433147 AF091434 Hs. 43080 platelet derived growth factor C 2. 77 1. 70 412326 R07566 Hs. 73817 small inducible cytokine A3 (homologous 2. 76 2. 18 425787 AA363867 Hs. 155029 ESTs 2. 75 2. 42 450172 Nom-005864 Hs. 24587 signal transduction protein (SH3 contain 2. 75 2. 36 421773 W69233 Hs. 112457 ESTs 2. 73 5. 59 408536 AW381532 Hs. 135188 ESTs 2. 73 5. 17 437143 AW204056 Hs. 8917 ESTs 2. 72 1. 84 452862 AW378065 Hs. 8687 ADAMTS2 (adisintegrin-likeandmetallo 2. 70 1. 82 418394 AF132818 Hs. 84728 Kruppel-iike/ætor5 (intestinal) Z69 4. 62 410325 AB023154 Hs. 62264 KIAA0937 protein 2. 69 2. 32 447164 AF026941 Hs. 17518 vipirin ; similar to inflammatory respon 2. 69 3. 74 444984 H15474 Hs. 132898 fatty acid desaturase 1 2. 67 2. 36 434727 H43374 Hs. 7890 HomosapiensmRNAhrKIM1671 protein, 2. 65 1. 78 420876 AA918425 Hs. 177744 ESTs 2. 64 7. 26 426106 A1678765 Hs. 21812 ESTs 2. 64 2. 51 419517 AF052107 Hs. 90797 Homosapiensdone23620mRNAsequence 2. 64 2. 66 409509 AL036923 Hs. 322710 ESTs 2. 62 2. 09 426354 NM_004010 Hs. 169470 dystrophin (muscular dystrophy, Duchenne 2. 62 2. 68 432503 AA551196 Hs. 188952 ESTs 2. 62 4. 64 409341 AI963376 Hs. 12532 chromosome 1 open reading frame 21 2. 62 1. 74 421116 T19132 Hs. 101850 etinol-bindingprotein1, cellular 2. 62 2. 90 456247 R09746 gb : yf27d10. r1 Soaresfetalliverspleen 2. 61 3. 43 414217 Al309298 Hs. 279898 Homo sapiens cDNA : FU23165 fis, clone L 2. 60 3. 84 439706 AW872527 Hs. 59761 ESTs, Weakly similar to DAP1 HUMAN DEATH 2. 58 3. 49 440659 AF134160 Hs. 7327 claudin 1 2. 57 3. 97 459710 Al701596 Hs. 121592 ESTs 2. 57 3. 59 430937 X53463 Hs. 2704 glutathione peroxidase 2 (gastrointestin 2. 56 3 35 433882 U90441 Hs. 3622 pnxdlagen-prdine, 2-oxoglutarate 4-di 2. 51 3. 75 427666 Al791495 Hs. 180142 calmodulin-likeskin protein (CLSP) 2. 51 3. 02 431103 M57399 Hs. 44 pieiotrophinfheparin binding growth fac 2. 47 3. 53 449550 AA353125 Hs. 184721 ESTs 2. 43 4. 22 424675 NM 005512 Hs. 151641 glycoprotein A repetitions predominant 2. 40 6. 22 442000 H38671 Hs. 8071 KIM0735 gene product ; synaptic vesicle 2. 38 3. 14 427122 AW057736 Hs. 323910 HER2 receptor tyrosine kinase (c-erb-b2, 2. 36 3. 59 420039 NM004605 Hs. 94581 suMotransterase/amily, cytosolic, 2B, 2. 36 2. 91 412477 AA150864 microsomal utathioneS-transferase1 2. 34 4. 15 450693 AW450461 Hs. 203965 ESTs 2. 32 3. 93 406433 Target Exon 2. 29 3. 20 423017 AW178761 Hs. 227948 serine (or cysteine) proteinase inhibito 2. 24 4. 40 422158 L10343 Hs. 112341 protease inhibitor 3, skin-derived (SKAL 2. 23 4. 87 421314 BE440002 Hs. 180324 Homo sapiens, clone I MAGE : 4183312, mRNA, 2. 23 4. 22 422083 NM W1141 Hs. 111256 arachidonate1S-lipoxygenae, secondbp 2. 22 5. 71 442503 AF147078 Hs. 150853 p53-responsive gene 5 2. 21 4. 86 418007 M13509 Hs. 83169 matrix metalloproteinase 1 (intersti6al 2. 19 3. 90 442572 A1001922 Hs. 135121 hypothetical protein FLJ22415 2. 16 2. 87 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa 2. 13 3. 27 414521 D28124 Hs. 76307 neuroblastoma, suppressionottumorigeni 2. 09 5. 28 428899 AA744610 Hs. 194431 paladin 2. 08 3. 76 417079 U65590 Hs. 81134 interleukin 1 receptor antagonist 2. 06 3. 09 439496 BE616501 Hs. 32343 Homosapiens, SimilartoRIKENcDNA1110 2. 05 2. 88 450423 AA486735 Hs. 31869 sialoadhesin 2. 02 3. 04 444105 AW189097 ESTs 2. 01 3. 05 430410 AF099144 Hs. 347933 tryptase beta 1 2. 01 3. 71 409453 A1885516 Hs. 95612 ESTs 2. 01 4. 34 429655 U48959 Hs. 211582 myosin, tight potypeptidekinase 2. 00 5. 28 432374 W68815 Hs. 301885 Homo sapiens CDNA FU 11346 fis, clone PL 1. 99 3. 59 447990 BE048821 Hs. 20144 small inducible cytokine subfamily A (Cy 1. 92 4. 16 451541 BE279383 Hs. 26557 plakophilin 3 1. 89 3. 90 425206 NM_002153 Hs. 155109 hydroxysteroid (17-beta) dehydrogenase 2 1. 89 3. 29 410197 NM_05518 Hs. 59889 3-hydnoxy-3methylglutaryl-CoenzymeAsy 1. S4 3. 04 401760 Target Exon 1. 84 3. 32 427579 AA366143 Hs. 179669 hypothetical protein FLJ20637 1. 83 4. 69 424263 M77640 Hs. 1757 L1 cell adhesion molecule (hydrocephalus 1. 83 2. 96 452208 AA024792 Hs. 31895 hypothetical protein MGC4093 1. 82 3. 70 420074 AA253425 Hs. 19W74 ESTs 1. 81 2. 90 429299 Api620463 Hs. 347408 hypothetical protein MGC13102 1. 79 3. 65 427540 R12014 Hs. 20976 ESTs 1. 77 2. 92 429259 AA420450 Hs. 292911 Plakophilin 1. 76 3. 65 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 1. 75 4. 06 453556 AA425414 Hs. 33287 nuclearfactorl/8 1. 74 3. 07 436895 AF037335 Hs. 5338 carbonic anhydrase Xil 1. 73 3. 22 406851 AA609784 major histocompatibility complex, class 1. 73 3. 96 444726 NM_006147 interferon regulatory factor 6 1. 71 3. 65

444781 NM 014400 Hs. 11950 GPI-anchored metastasis-associated prote 1. 71 4. 13 446051 BE048061 Hs. 37054 ephrin-A3 1. 68 3. 61 408522 Api541214 Hs. 46320 Smallproline-richproteinSPRK [human, 1. 67 3. 00 450835 BE262773 Hs. 25584 hypothetical protein FLJ10767 1. 66 3. 11 432004 BE018302 Hs. 2894 placenta growth factor, vascular endoth 1. 66 3. 23 431179 Api338644 Hs. 195432 aldehyde dehydrogenase 2 family (mitocho 1. 64 3. 29 415213 NM 002933 Hs. 78224 ribonuclease. RNase A family, 1 (pancrea 1. 57 3. 94 423184 NM004428 Hs. 1624 ephrin-A1 1. 56 Z88 414694 NM 015362 Hs. 76907 HSPC002 protein 1. 56 2. 92 458746 AI380797 Hs. 158992 ESTs 1. 56 2. 92 433091 Y12642 Hs. 3185 lymphocyte anfigen 6 complex, locus D 1. 55 3. 75 438367 N79688 Hs. 204354 ras homolog gene family, member B 1. 54 4. 56 403903 C5001632* : giII0645308igblAAG21430. 1 JACOO 1. 53 3. 99 445656 W22050 Hs. 21299 ESTs, WeaklysimilartoAF1518401 CGI-8 1. 52 3. 16 443604 C03577 Hs. 9615 myosin regulatory light chain 2, smooth 1. 50 4. 25 429211 AF052693 Hs. 198249 gap junction protein, beta 5 (connexin 3 1. 50 3. 35 415274 AF001548 Hs. 78344 myosin, heavy polypeptide 11, smooth mus 1. 49 3. 21 418226 AA424202 Hs. 83834 cytochrome b-5 1. 49 3. 90 454194 BE141599 gb : QV2-HT0083-07t299-018-h01HT0083Homo 1. 48 2. 98 434879 M34572 Hs. 159263 collagen, type VI, alpha 2 1. 46 3. 26 418400 BE243026 Hs. 301989 KIAA0246 protein 1. 46 4. 00 409178 BE393948 Hs. 50915 kallikrein 5 1. 45 2. 94 433662 W07162 Hs. 150826 RAB25 RAB25, member RAS oncogene family 1. 44 3. 18 429002 AW248439 Hs. 2340 junction plakoglobin 1. 43 3. 07 422087 X58968 Hs. 11130t matrix metalloproteinase 2 (gelatinase A 1. 40 4. 61 452934 AA581322 Hs. 4213 hypothetical protein MGC16207 1. 38 3. 11 417483 BE549343 Hs. 82208 acyl-Coenzyme A dehydrogenase, very long 1. 37 4. 32 427929 BE613835 Hs. 181159 HomosapiensmRNA ; cDNADKFZp434F0217 (t 1. 37 2. 99 425184 BE278288 Hs. 155048 Lutheran blood group (Auberger b an6gen 1. 36 3. 17 407143 C14076 Hs. 332329 EST 1. 36 2. 99 416950 AL049798 Hs. 80552 dermatopontin 1. 35 3. 39 406799 AA908548 gb : og83g12. s1NCI CGAP_Ov8 Homo sapiens 1. 34 3. 17 442599 AF078037 Hs. 324051 ReiA-associated inhibitor 1. 33 3. 30 413659 BE155647 gb : PM2-HT0353-130100-002-eO9HT0353Homo 1. 32 2. 89 454478 AW805749 superoxide dismutase 2, mitochondrial 1. 30 3. 50 404467 Target Exon 1. 29 3. 57 452516 AA058630 Hs. 29759 RNA POLYMERASE I AND TRANSCRIPT RELEASE 1. 28 3. 00 412524 AA417813 Hs. 44208 hypothetical protein FU23153 1. 27 3. 05 422354 U20982 Hs. 1516 insulin-like growth factor-binding prote 1. 24 2. 86 406711 N25514 Hs. 77385 myosin, light polypeptide 6, alkali, smo 1. 24 3. 29 450796 NM001988 Hs. 25482 envoplakin 1. 23 3. 21 431526 Y10129 Hs. 258742 myosin-binding protein C, cardiac 1. 23 3. 65 452791 AA227581 Hs. 30634 hypothetical protein FU20509 1. 22 2. 90 406742 A1468091 Hs. 279860 tumor protein, translationally-controlle 1. 19 3. 47 406712 M31212 Hs. 77385 myosin, light polypepGde 6, alkali, smo 1. 18 2. 91 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 1. 10 3. 50 413048 M93221 Hs. 75182 mannose receptor, C type 1 1. 00 2. 99 453165 S74727 Hs. 32042 aspartoacylase (aminoacylase 2, Canavan 1. 00 2. 91 TABLE 59B : Pkey : Unique Eos probeset identifier number CAT number. Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 412636 143S_1 M77830 NM 004415 AF139065 BG681115 BG740377 BU. 712964 BG000656M128470 Bl438324 H27408BE931630 BE167165AW370827AW370813 J05211 BG698865 BG740734 BG680618 BG739778 Bai765807 BM353403 BM353248 AW177784 AW205789 AW951576 AW848592 BE182164 BF149266 BE940187 Bl060445 Bl060444 BF350983 BE720095 BE720069 BE715154 BE082584 BE082576 BE004047 AA857316 81039774 BE713818 BE713548 AW170253 BE160433 81039775 AW886475 BM462504 BE931734 8F149264 AA340777 BF381183 BG621737 AU127260 AW364859 BF993352 BG223489 BE819009 BF381184 BE715956 R58704 AA852212 AW366566 B1090358 BF087707 BE819046 BE819005 AA377127 BE073467 BE819069 BE819048 B1036306 BG990973 B1040954 BF919911 AU140155 AI951766 AI434518 AW804674 BF752969 BE837009 BE925826 BF149265 AW995615 BE814264 Bol039782 AU140407 BE144243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF086994 BF592276 BE082507 BE082514 BE082505 BF873693 AW068840 AW847678 BF804153 AW365157 BE813930 BE002030 AW365153 BE184941 BF749421 BE184920 BF839562 BE184933 BF842254 BE698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 W39488 C04715 BF096124 BE865341 AW799304 AL603116 BE149760 BE705967 BE705966 BE705968 AW848723 AW376699 AW376817 AW376697 8GO05097 BF751115 BE696084 AW848371 AW376782 AW848789 AW849074 AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 BG005197 BF350086 BE715196 BE715155 BF752396 BF093817 BF831190 BF752409 BE006561 BG959922 BF094833 BF094748 BF094583 AW377699 AW607238 BE082519 AW377700 BF349467 Al190590 Al554403 Al39Z926 AU158477 Bl467252 AU159919 Al760816 BF082516 Al439101 M451923 Al340326 Ai590975 B1791553 Al7W963 AI142882 AA039975 AA946936 AA644381 BM314884 AA702424 AI417612 AW190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW 1 66S07 Al 346078 W95070 AA149191 AA026864 AI830049 AW780435 A1078449 AI819984 AI858282 81468588 AI860584 A1025932 AA026047 AA703232 AA658154 AA515500 AW192085 AA918281 T77861 Al927207 Al205263 BF082491 AW021347 Al568096 BE939862M08S866 D12062 AA056527 AA782109 W19287 W02156 AW150038 AA022701 T87181 H44405 Ai910434 BF082513 A1494069 A1270027 A1635878 AA128330 BG681425 BE706078 R20904 BG680059 BG676647 BF764409 AA026654 AV745530 81762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 At571075 BE067786 AV721320 A1022862 N29754 C03378 N84767 AA131077 H30146 BE714290 A1686869 A1568892 Al915596 AW105614 A1887258 A1538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 A1905927 BF992780 AW853812 BG954443 B1770853 BG679406 BG740832 BG681087 BG698430 AA455100 T87267 BE696209 BE696210 B1089483 BE006273 BE872225 AW391912 BE925515 BG677012 BG741970 AA026480 BE705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 B1040941 AA337270 AW384371 AW847442 B1058659 BE813665 W95048 W25458 AW177786 AA025851 BE931733 BF154837 BG949393 BE714441 AW996245 BE711801 Al284090 BE064323 BE719390 BE940148 BG991212 BF375714 BF349522 BG996267 T48793 B1013292 BE001925 AW365156 AW365154 AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W3B382 A1498487

409010 10331-1 AL575207AL551714 BM014781 BGS42863 BG771232AA429722 A1377511 A1770155AA716665 BG003427 AA810811 AA442760AA128610 AA059411 AI796263 AI494075 AI572127 AA420992 BF436083 AI648675 AA878813 BI488614 BG700886 AA128609 AV702879 AA731146 AI580336 AI373224 AA919169 AI758175 AA976350 BG701414 BF057794 AW135598 AA062583 BI549631 AI185077 AA933879 AW024454 AA193289 AA045194 BG928396 BE856883 BF435859 AA196423 AW237471 R99289 D61992 BE856637 BF368270 AA194235 N51319AA383499 N63065 BG548812 BF027898 BG779448 409760 865166 1 AA302840T93016T92950AU184997AA077551 410099 16732_1 AK055674 AW965247 AV751598 AA290926 R53043 AA331387 AK056148 Bl917678 BGS19395 BG911971 BG820167 Al 174254 AA348720 AA364503 BG714279 AW893230 AA081774 H24222 AV727176 BF875715 AA081630 BE000834 AA334880 AL563737 8G029709 W52882 AI439658 BE551237 AA283724 BF109530 Al457096 Al805992 BE467736 AA693467 Al697593 Al887863 Al167419 AW9019SO AW901768 BE702179 AA484549 T23811 BE327043 AA716027 AA917004 AA167714 BF339675 AA084618 Al418634 T31586 AA436630 Al366472 M706191 Al422304 Al204899 Al041169 AA211402 AW827081 AA788593 T32736 AI767935 AA747914 T03534 AW959843 AL119527 BE327037 AW901982 AW993370 AW901977 AW902071 W60090 N79906 D52685 T07735 BE702069 BE702172 T08671 BE767121 BE767117 BE767113 456247 2142387_1 R10170 R09746 412477 8669_2 AI220117 AI857837 AI218371 BM091400 AI304964 AI198508 AI40W38 AW571549 AW950042 A1089943 AA437280 AU150878 BF197070 A1267984 BF594181 BF196688 AI433152 AI33892t AI620364 AI280t97 AA652531 A1674938 AI342447 AI620350 AI281295 AI148621 N54787 AI338121 Ai281153 N51899 A1087072 AA954788 AW069054 Api346309 BG529629 AI340135 BF083036 At167365 AW819657 AA935468 A) 467868 AW148701 AI383720 BE047685 AW015498 AA937149 AA708346 AW771478 AW802508 H53334 AW389204 AW798230 AI553922 AI560688 AW950043 AI961682 AV706506 R01853 AA126514 N62757 A1536893 A1926052 A1418720 N99964 A1568933 A1915737 A1080691 Al 185358 N48996 N68575 H82824 H60037 A1247247 T95664 BF593863 AI749637 AW088541 AA991294 AA887452 A1073726 AA633132 AA629674 AA629649 AA629656 AA578595 AI168758 AA804572 A1085786 AA994396 AA991209 AA948663 AA929054 AA927952 T87001 AA928210 AA629296 AW802261 AW384129 BF744400 AA194110 Al382839 AA194837 AA406284 AI250750 R37035 AI525586 W01244 444105 649788 1 AW189097 A1123917 A1123926 406851 0 0 AA609784 R97304 444726 35032 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 AI745383 AU159045 AI693500 AW293668 AW371408 BE856107 A1338042 AW188320 AI698246 BE673290 AW297653 AA156532 A1017342 AI916754 Ai190644 Al184302 AA857671 BE857018 AI307420 AI313St157 AW204327 AW664668 AW274339 AA582788 AI345741 AW301433 AI873468 AW137388 BF718731 BF718413 AA87'7495 BF001575 AI824693 AW849604 AW849405 AW849396 AW849173 BE673179AI611327M705753 BE715478 AW849414 AW849399 Al085759 Al140849 T67412AI889885 AW104647 A1912495AI889874AI744241 BE717113BE717108BE715564AI872527AA029457CO033BA1469558BE7155 77AA045413BF843813 454194 171445_1 BE141599 AW845895 AW178095 BE140914 BE140909 AW178107 AW178094 AW845883 BF349267 AW845898 AW845811 AW845814 BF767720 406799 0 0 AA908548 413659 1526081 1 BE155647 BE155627 454478 4273_16 AW796921 AW798102 AW805749AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 TABLE 59C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers.'Dunham, et a !.' refers to the publication entiUed'The DNA sequence of human chromosome 22"Dunham, et ai. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 401780 7249190 Minus 28397-28617, 28920-29045, 29135-29296, 2941 402075 8117407 Plus 121907-122035, 122804-122921, 124019-12416 401785 7249190 Minus 165776-165996, 166189166314, 16640& 6656 401781 7249190 Minus 83215-83435, 83531-83656, 83740-83901, 8423 406433 9256507 Plus 58094-58565 401760 9929699 Plus 83126-83250, 85320-85540, 94719-95287 403903 7710671 Minus 101165-102597 404467 8077630 Minus 24951-25853 TABLE 60A : ABOUT 53 GENES UPREGULATED IN BENIGN NEVI RELATIVE TO NORMAL TISSUES Table 60A lists about 53 genes upregulated in benign nevi relative to normal tissues. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : average of benign nevi Als divided by the 90th percentile of normal tissue Als R2 : average of benign nevi Als divided by 90th percentile of normal 6ssue Als, where the 15th percentile of normal 6ssue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 430377 NM 001922 Hs. 301865 dopachrome tautomerase (dopachrome delta 8. 69 5. 62 409601 AF237621 Hs. 80828 keratin 1 (epidermoiytichyperkeratosis) 8. 37 13. 47 430686 NM_001942 Hs. 2633 desmoglein 1 7. 26 4. 78 406964 M21305 FGENES predicted novel secreted protein 6. 50 3. 73 426555 Nom000372 Hs. 2053 tyrosinase (oculocutaneous albinism IA) 6. 40 7. 35 429852 AB010445 Hs. 225948 small inducible cytokine subfamily A (Cy 6. 23 8. 85 430822 AJ005371 Hs. 248017 glyceraldehyde-3-phosphate dehydrogenase 5. 49 4. 32 420208 BE276055 Hs. 95972 silver (mouse homolog) like 5. 45 9. 84 431360 NM_000427 Hs. 251680 loricrin 3. 88 3. 00 421773 W69233 Hs. 112457 ESTs 3. 80 9. 04 438380 T06430 Hs. 6194 chondroi6n sultate proleoglycan BEHAB/b 3. 74 4. 23 431089 BE041395 ESTs, Weakly similar to unknown protein 3. 21 2. 34 420798 W93774 Hs. 99936 keratin 10 (epidermoiytic hyperkeratosis 3. 08 3. 20 442503 AF147078 Hs. 150853 p53-responsive gene 5 2. 88 5. 01 405451 dihydropyrimidinase-like 3 2. 88 2. 85 452240 Api591147 Hs. 61232 ESTs 2. 86 1. 90 402525 NM002699' : Homo sapiens POU domain, clas 2. 78 2. 72 413171 AA318325 Hs. 75219 tyrosinase-related protein 1 2. 65 5. 58 439496 BE616501 Hs. 32343 Homosapiens, SimilartoRIKENcDNA1110 2. 55 3. 18 422656 A1870435 Hs. 1569 LIM homeobox protein 2 2. 45 2. 38

453317 NM 002277 Hs. 41696 keratin, hair, acidic, 1 2. 34 3. 76 420783 Api659838 Hs. 99923 lec6n, galactoside-binding, soluble, 7 2. 33 2. 43 422511 AU076442 Hs. 117938 collagen, type XVII, alpha 1 2. 28 2. 00 427666 Api791495 Hs. 180142 calmodulin-like skin protein (CLSP) 2. 28 2. 50 459702 Al204995 gb : anO3cO3. x1 Stratagene schizo brain S1 2. 25 1. 85 451668 Z43948 Hs. 326444 cartilage acidic protein 1 2. 23 2. 42 431703 AA514264 Hs. 4437 triosephosphate isomerae 1 2. 15 2. 20 453511 AL031224 Hs. 33102 AP-2 beta transcription factor 2. 13 2. 20 401780 Nom005557' : Homo sapiens keratin 16 (foca 2. 13 2. 02 416640 BE262478 Hs. 79404 neuron-specific protein 2. 11 2. 02 444105 AW189097 ESTs 2. 11 1. 46 428748 AW593206 Hs. 98785 Ksp37 protein 2. 09 1. 52 418067 A1127958 Hs. 83393 cystatin E/M 2. 09 2. 32 417017 AA976064 Hs. 180842 ribosome protein L13 2. 08 2. 52 401781 Target Exon 2. 02 2. 03 407178 AA195651 AP-2 beta transcription factor 1. 88 2. 17 452308 A1167560 Hs. 61297 ESTs 1. 84 2. 38 429348 AJ242859 Hs. 199731 Langerhanscei) specific c-typetectin 1. 83 3. 26 402880 TargetExon 1. 69 2. 10 434276 AF123659 Hs. 93605 leucine zipper, puta6ve tumor suppresso 1. 69 2. 20 401963 NM_006311 : Homo sapiens nuclear receptor 1. 66 2. 02 424010 AL080188 Hs. 137556 Homo sapiens mRNA ; cDNADKFZp434A132 (fr 1. 65 2. 05 432800 BE391046 Hs. 278962 AIM-1 protein 1. 61 2. 83 400328 X87344 transporter 2, ATP-binding cassette, sub 1. 57 2. 27 412580 AA113262 Hs. 17901 Homo sapiens, clone IMAGE : 3937015, mRNA, 1. 55 2. 42 435292 N20514 Hs. 172965 ESTs 1. 53 2. 21 408561 Al308037 Hs. 84120 hypothetical protein MGC13016 1. 52 2. 01 427923 AW274357 Hs. 301406 hypothetical protein PP3501 1. 47 2. 71 447763 8E619911 Hs. 115803 hypothetical protein 1. 40 2. 10 454478 AW805749 superoxide dismutase 2, mitochondrial 1. 30 2. 36 427289 A1097346 phosphoserine aminotransferase 1. 24 2. 02 430513 AJ012008 Hs. 241586 G6C protein 1. 20 2. 18 411388 X72925 Hs. 69752 desmocollin 1 1. 00 2. 43 TABLE GOB : Pkey : Unique Eos probeset identifier number CAT number. Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 431089 125941 2 BG940189 AW063489 AA715980 BF001091 BF880066 AA666102 AA621946 AA491826 459702 539529_1 BG207209 BE166299 Al204995 BG1993S5 AW969908 AA528756 AW440776 B1044354 444105 6497881 AW189097AI123917AN23926 407178 683007_1 AW235123M195651 454478 4273 16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 427289 18202 BC007350 BG766159 BG769338 BG761999 BG744385 BG770572 AW370610 AW370581 AA978353 AW327973 AW402425 A1889380 AA868504 AW612968 AA630644 Api751211 N26980 Al394506 M747849 BF154926 BF477185 AA649647 R39135 A1750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW370651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 B) 261497 Bid8403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 BI018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340083 Z20199 TABLE 60C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et a !.' refers to the publication entiUed'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nudeotide positions of predicted exons. Pkey Ref Strand Ntposition 405451 7622517 Minus 145949-146227 402525 9800048 Minus 19748-20683 401780 7249190 Minus 28397-28617, 28920-29045, 29135-29296, 2941 401781 7249190 Minus 83215-83435, 83531-83656, 83740-83901. 8423 402880 9926561 Minus 4155541865 401963 3126783 Plus 51382-51521 TABLE 61A : ABOUT 72 GENES UPREGULATED IN BENIGN NEVI RELATIVE TO PRIMARY MELANOMAS Table 61A lists about 72 genes upregulated in benign nevi relative to primary melanomas. Genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value rejecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene btle R1 average of benign nevi Als divided by the 90th percentile of primary melanoma Als R2 average of benign nevi Als divided by the 90th percentile of primary melanoma Als, where the 1 5th pern61e of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Tiüe R1 R2 431103 M57399 Hs. 44 pleiotrophin (heparinbindinggrowthfac 3. 80 2. 50 424897 D63216 Hs. 153684 frizzled-related protein 3. 40 2. 69 429852 AB010445 Hs. 225948 small inducible cytokine subfamily A (Cy 2. 90 3. 25 431089 BE041395 ESTs, Weakly similar to unknown protein 2. 82 1. 56

456034 AW450979 gb : UI-H-BI3-àa-a-12-0-Ul. s1 NCl_CGAP_Su 2. 73 3. 00 417017 AA976064 Hs. 180842 ribosomal protein L13 2. 71 3. 73 402880 Target Exon 2. 56 3. 55 422656 At870435 Hs. 1569 LIM homeobox protein 2 2. 45 3. 38 426451 Api908165 Hs. 169946 GATA-binding protein 3 (T-cell receptor 2. 41 1. 91 423467 AK000214 Hs. 129014 hypothetical protein FLJ20207 2. 32 2. 24 424797 AA622394 Hs. 153177 ribosome protein S28 2. 29 2. 53 459702 AI204995 gb : anO3cO3. x I Stratagene schizo brain S 1 2. 25 2. 19 406964 M21305 FGENES predicted novel secreted protein 2. 24 1. 65 428748 AW593206 Hs. 98785 Ksp37 protein 2. 09 1. 43 402525 NM_002699' : Homo sapiens POU domain, clas 2. 06 2. 03 415823 R81864 Hs. 205103 ESTs 2. 05 1. 87 412432 AA126311 Hs. 9879 ESTs 2. 05 2. 48 421733 AL119671 Hs. 1420 fibroblast growth factor receptor 3 (ach 2. 03 2. 20 414876 AW950925 Hs. 924 crystallin, mu 2. 02 2. 30 432306 Y18207 Hs. 303090 protein phosphatase 1, regulatory (inhib 2. 02 2. 39 424010 AL080188 Hs. 137556 Homo sapiens mRNA ; cDNA DKFZp434A132 (fr 1. 95 2. 72 453317 NM002277 Hs. 41696 keratin, hair, acidic, 1 1. 95 2. 66 452887 Al702223 Hs. 107253 hypothetical protein DKFZp761F241 1. 88 2. 85 410545 U32324 Hs. 64310 interleukin 11 receptor, alpha 1. 85 3. 07 400496 ENSP00000224716' : GTP-binding protein SAR 1. 84 2. 09 406972 M32053 gb : Human H19 RNA gene, complete cds. 1. 83 4. 14 406266 Target Exon 1. 75 2. 38 414309 AK000639 Hs. 75884 DKFZP586A011 protein 1. 73 2. 80 416250 AA581386 Hs. 73452 hypothetical protein MGC10791 1. 72 2. 27 451849 Al199261 Hs. 27191 hypothetical protein from clone 24796 1. 70 2. 09 441134 W29092 Hs. 346950 llulare6noicæid-bindingprotein1 1. 68 2. 37 401963 NM006311 : Homo sapiens nuclear receptor 1. 66 2. 38 430947 U01212 Hs. 248153 olfactory marker protein 1. 65 2. 00 413391 A1223328 Hs. 75335 glycine amidinotransferase (L-arginine : g 1. 63 2. 18 406387 Target Exon 1. 57 2. 14 405776 405776 cytochrome c-1 1. 55 2. 23 410677 NM 003278 Hs. 65424 tetranectn (plasminogen-binding protein 1. 53 3. 26 406807 AA057605 Hs. 180920 ribosomal protein S9 1. 53 2. 67 420438 AW403621 Hs. 1311 CD1C antigen, c polypeptide 1. 52 2. 09 422089 AA523172 Hs. 103135 ESTs. WeaklysimilartoSFR4_HUMANSPLIC 1. 52 2. 66 456898 NM_001928 Hs. 155597 D component of complement (adipsin) 1. 48 2. 57 402412 Target Exon 1. 48 2. 42 427795 BE268268 Hs. 180842 ribosomal protein L13 1. 48 3. 48 452547 AA335295 Hs. 74120 adipose specific 2 1. 47 3. 89 414323 NM 014759 Hs. 334688 KIAA0273 gene product 1. 46 3. 14 425831 U46689 Hs. 159608 aldehyde dehydrogenase 3 family, member 1. 45 2. 09 457090 AL080243 Hs. 180920 ribosomal protein S9 1. 40 2. 86 445431 AF137386 Hs. 12701 ptasmotipin 1. 39 2. 00 445636 AW105401 ribosomal protein L29 1. 38 2. 08 414682 AL021154 Hs. 76884 inhibitor of DNA binding 3, dominant neg 1. 37 3. 32 406845 Api567284 Hs. 119598 dbosomal protein L3 1. 37 2. 04 406808 Api690307 Hs. 180920 ribosome protein S9 1. 36 3. 32 403986 Target Exon 1. 34 2. 09 402218 NMJ) 22165' : Homo sapiens Lin-7b protein 1. 31 2. 16 400649 Target Exon 1. 29 2. 07 432647 Api807481 Hs. 278581 fibroblast growth factor receptor 2 (bac 1. 28 2. 40 403211 NM 005400' : Homo sapiens protein kinase C 1. 26 2. 13 452678 Api243131 Hs. 164661 ESTs, Weakiy similar to TGLXHUMANPROTE 1. 26 2. 14 406889 D50310 Hs. 79933 cyclin 1 1. 26 2. 37 447299 AF043897 Hs. 18075 chromosome 9 open reading frame 3 1. 25 2. 39 404406 Target Exon 1. 24 2. 09 432894 AW167668 Hs. 279772 brain specific protein 1. 23 2. 28 406757 T65957 Hs. 77039 ATP synthae, H transporting, mitochondr 1. 21 2. 01 425883 AL137708 Hs. 161031 Homo sapiens mRNA ; cDNA DKFZp434K0322 (f 1. 20 2. 07 409726 Al479341 Hs. 724 thyroid hormone receptor, alpha (avian e 1. 17 2. 62 436398 H87136 Hs. 5174 ribosome protein S17 1. 17 2. 42 444674 BE562200 Hs. 244 amino-terminalenhancerofsplit 1. 16 2. 02 402450 Target Exon 1. 16 2. 08 406758 AA552326 Hs. 77039 ATP synthase, H transporting, mitochondr 1. 16 2. 03 431243 U46455 Hs. 252189 syndecan 4 (amphiglycan, ryudocan) 1. 13 2. 23 407032 U73799 gb : HumandynætinmRNA, pa6åcds. 1. 10 2. 01 402921 ENSP00000244047' : Cadherin-like protein V 1. 00 2. 00 TABLE 618 : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 431089 125941_2 BG940189 AW063489 AA715980 BF001091 BF880066 AA666102AA621946 AA491826 456034 685586 1 AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BEt68945 459702 5395291 BG207209 BE166299 A1204995 BG199355 AW969908 AA528756 AW440776 Bl044354 445636 8561-5 BF339388 A1345516 BG391657 BE708967 BG026034 BE261703 H56716 H65572 H93801 T48830 R96953 R96989 R39707 BE867593 AA090310 AA090672 TABLE 61C : Pkey : Unique number corresponding to an Eos probeset

Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et al.'refers to the publication entitled The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. NLposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Position 402880 9926561 Minus 41555-41865 402525 9800048 Minus 19748-20683 400496 9743564 Plus 41515-41695 406266 7528342 Minus 2365-2518 401963 3126783 Plus 51382-51521 406387 9256180 Plus 116229-116371. 117512-117651 405776 7159748 Minus 105911-107251 402412 7408036 Plus 75075-75679 403986 8576059 Plus 90692-91238 402218 7689783 Plus 127677-127886 400649 8117705 Plus 93097-93792 403211 7630841 Minus 159211-159369 404406 7329316 Minus 47543-47928 402450 9796674 Plus 13753&137682, 137920-138045 402921 7981303 Minus 52242-52384, 55599-55858, 57124-57309, 5963 TABLE 62A ABOUT 121 GENES UPREGULATED IN BENIGN NEVI RELATIVE TO NORMAL SKIN Table 62A lists about 121 genes upregulated in benign nevi relative to normal skin. These genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 average of benign nevi Als divided by the 90th percentile of normal skin Als R2 average of benign nevi Als divided by the 90th percent of normal skin Als, where the 15th percenGle of normal Gssue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 430377 NM001922 Hs. 301865 dopachrome tautomerase (dopachrome delta 8. 69 7. 66 438380 T06430 Hs. 6194 chondroitin sulfate proteoglycan BEHAB/b 6. 71 8. 11 406964 M21305 FGENES predicted novel secreted protein 6. 50 3. 35 426555 NM 000372 Hs. 2053 tyrosinase (oculocutaneous albinism IA) 6. 40 4. 32 430822 AJ005371 Hs. 248017 glyceraldehyde-3-phosphate dehydrogenase 5. 16 4. 12 415752 BE314524 Hs. 78776 putative transmembrane protein 4. 77 3. 59 431103 M57399 Hs. 44 pleiotrophin (heparin binding growth fac 4. 63 4. 99 451668 Z43948 Hs. 326444 cartilage acidic protein 1 4. 62 6. 04 449644 AW960707 Hs. 148324 ESTs 3. 97 3. 41 435056 AW023337 Hs. 5422 glycoprotein M6B 3. 42 2. 29 431089 BE041395 ESTs, Weakly similar to unknown protein 3. 21 2. 57 452973 H88409 Hs. 40527 ESTs 3. 16 3. 12 408393 AW015318 Hs. 23165 ESTs 3. 12 2. 00 417355 D13168 Hs. 82002 endothelin receptor type 8 3. 11 2. 45 415314 N88802 Hs. 5422 glycoprotein M6B 2. 86 2. 39 417632 R20855 Hs. 5422 glycoprotein M6B 2. 78 2. 16 457211 AW972565 Hs. 32399 ESTs, Weakly similar to S51797 vaodilat 2. 75 3. 71 456034 AW450979 gb : UI-H-BI3ala-a-12-0-Ul. s1 NCI_CGAP Su 2. 73 3. 00 404356 Target Exon 2. 63 2. 69 414876 AW950925 Hs. 924 crystallin, mu 2. 57 3. 15 420208 BE276055 Hs. 95972 silver (mouse homolog) like 2. 46 2. 89 422656 Al870435 Hs. 1569 LIM homeobox protein 2 2. 45 2. 20 439963 AW247529 Hs. 6793 platelet-activafing factor acetylhydrola 2. 43 2. 11 432222 Al204995 gb : anO3cO3. x1 Stratagene schizo brain S1 2. 31 1. 96 401116 TargetExon 2. 29 2. 24 410326 A1368909 Hs. 47650 ESTs 2. 27 2. 77 459702 AI204995 gb : anO3cO3. x1 Stratagene schizo brain S1 2. 25 3. 49 435730 AB020635 Hs. 4984 KIAA0828 protein 2. 24 2. 24 404977 Insulin-like growth factor 2 (somatomedi 2. 24 1. 99 414221 AW450979 gb : UI-H-BI3a1a-a-12-0-Ul. s1 NCI CGAP Su 2. 16 2. 36 437862 AW978107 Hs. 5884 HomosapiensmRNA : cDNADKFZp586C0224 (f 2. 13 2. 09 402181 Target Exon 2. 12 2. 74 447907 Api439110 Hs. 170796 ESTs 2. 05 2. 02 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso 2. 04 3. 14 459246 NM_006834 Hs. 32217 RAB32, memberRASoncogenefamily 2. 02 1. 83 405451 dihydropyrimidinase-like 3 2. 01 2. 00 446727 AB011095 Hs. 16032 KIAA0523 protein 2. 01 2. 36 417017 AA976064 Hs. 180842 ribosome protein L13 2. 00 2. 37 413171 AA318325 Hs. 75219 tyrosinase-related protein 1 1. 94 2. 77 408209 NM 004454 Hs. 43697 ets variant gene 5 (ets-related molecule 1. 94 2. 76 455657 BE065209 gb : RC1-BT0314-310300-015-b12 BT0314 Homo 1. 92 2. 91 419200 AW966405 EST 1. 85 2. 91 419687 A1638859 Hs. 227699 ESTs, Weakly similar to T203 HUMAN TRANS 1. 84 2. 27 402217 C19001662* : gil67538721reqNP-034345. 11 i 1. 83 2. 33 406040 Target Exon 1. 81 2. 04 435292 N20514 Hs. 172965 ESTs 1. 81 3. 41 430947 U01212 Hs. 248153 olfactory marker protein 1. 79 2. 00 434574 A1424458 Hs. 33470 ESTs 1. 78 4. 00

403532 NM024638 : Homo sapiens hypothetical prot 1. 75 2. 06 402829 C1002500 : gil67542541refiNP-034610. 11 hea 1. 72 2. 20 403828 C4000447* : gil77055701reqNP 038851. 11 KI 1. 72 2. 04 453837 AL138387 Hs. 256126 baculoviral IAP repeal-containing 7 (liv 1. 68 2. 40 407826 AA128423 Hs. 40300 calpain 3, (p94) 1. 67 2. 13 441253 Al632744 Hs. 129501 ESTs 1. 67 2. 13 405776 cytochrome c-1 1. 66 2. 36 430540 AW245422 Homo sapiens cDNA : FLJ22105 fis, cfone H 1. 66 2. 08 445745 AB007924 Hs. 13245 K) AA0455 gene product 1. 66 2. 34 401963 NM 006311 : Homo sapiens nuclearreceptor 1. 66 2. 97 402994 NM_002463 : Homo sapiens myxovirus (influ 1. 66 2. 56 406016 Target Exon 1. 65 2. 23 429186 BE503443 Hs. 112095 hypothetical protein DKFZp434F1819 1. 65 2. 30 402911 NM021158' : Homo sapiens protein kinase d 1. 63 2. 46 412926 Api879076 Hs. 75061 macrophage myristoylated alanine-rich C 1. 61 2. 28 440437 Api923201 Hs. 192352 ESTs 1. 59 2. 07 403960 ENSP00000174343' : KIAA0303 (FRAGMENT). 1. 59 2. 41 406266 Target Exon 1. 56 2. 16 424481 R19453 Hs. 1787 proteolipid protein 1 (Pelizaeus-Merzbac 1. 55 3. 14 403803 C4001432' : gil6W9515ldbjlBM84941. 1l (AB 1. 54 2. 04 407038 X00237 gb : Human F variable segment 5'to an6th 1. 53 2. 09 424412 H15512 Hs. 10043 hypothetical protein FU13074 1. 53 2. 46 431836 AF178532 Hs. 271411 beta-siteAPP-cleavingenzyme2 1. 52 2. 76 427923 AW274357 Hs. 301406 hypothetical protein PP3501 1. 52 3. 04 419849 BE041436 Hs. 93379 eukaryotic ranslation initiation factor 1. 51 3. 42 404790 C12001707' : gil7305215lrei ; NP_038599. 1lk 1. 50 2. 16 434596 T59538 gb : yb659l2. s1 Stratagene ovary (937217) 1. 48 2. 02 425069 AA687465 Hs. 298184 potassium voltage-gated channel, shaker-1. 47 4. 05 438549 BE386801 Hs. 21858 trinucleotide repeat containing 3 1. 46 2. 48 427289 A1097346 phosphoserine aminotransferase 1. 44 4. 46 425818 AB021225 Hs. 159581 marixmetalloproteinae17 (membrane-in 1. 43 2. 32 432800 BE391046 Hs. 278962 AIM-1 protein 1. 43 2. 08 447763 BE619911 Hs. 115803 hypothetical protein 1. 42 2. 21 443219 A1354669 Hs. 187461 ESTs, Weakly similar to C29149 proline-r 1. 41 2. 31 451489 NM 005503 Hs. 26468 amyloid beta (A4) precursor protein-bind 1. 41 2. 35 459641 AW064121 Hs. 279175 ESTs 1. 41 2. 01 405318 C7002129' : gil3638957lgbjMC36301. 1l (ACO 1. 40 2. 31 402343 Target Exon 1. 40 2. 35 447108 AW449602 Hs. 241493 natural killer-tumor recognition sequenc 1. 40 2. 11 431222 X56777 Hs. 273790 zona pellucida glycoprotein 3A (sperm re 1. 39 2. 06 400263 Eos Control 1. 39 2. 60 403986 Target Exon 1. 38 2. 09 437912 BE278594 Hs. 5912 F-box only protein 7 1. 36 2. 27 426020 AL110195 Hs. 166017 microphthalmia-associated transcription 1. 36 2. 77 401914 Target Exon 1. 33 2. 43 450395 BE048545 Hs. 161757 ESTs 1. 29 2. 01 425535 AB007937 Hs. 158287 KIAA0468 gene product 1. 29 2. 94 450358 AB010098 Hs. 24907 coronin, ac6n-binding protein, 2B 1. 28 2. 84 427560 AA405394 Hs. 161851 ESTs 1. 27 2. 14 402450 Target Exon 1. 27 2. 89 406885 D28423 gb : HumanmRNAforpre-mRNAsplicingfact 1. 26 3. 19 404067 Target Exon 1. 26 2. 45 406368 NM022355 : Homo sapiens putative dipeptid 1. 25 2. 06 454429 BE273437 Hs. 301406 hypothetical protein PP3501 1. 23 2. 07 414580 BE386918 gb : 601275386F1 NIH_MGC_20 Homo sapiens c 1. 22 2. 21 414060 BE246327 Hs. 123164 gb : TCBAP1E1967Pediatncpre-BceMacut 1. 22 2. 01 400867 cofilin 1 (non-muscle) 1. 21 2. 19 437026 AW976573 ESTs 1. 21 2. 31 402605 Target Exon 1. 20 2. 09 431008 H84058 Hs. 25734 ESTs, Weakly similar to BING1 [H. sapiens 1. 17 2. 22 448143 AF039704 Hs. 20478 ceroid-lipofuscinosis, neuronal 2, late 1. 17 2. 25 416630 H69392 Hs. 174051 smallnuclearnbonucleoprotein70kDpol 1. 16 2. 34 407239 AA076350 Hs. 67846 leukocyte immunoglobulin-like receptor, 1. 14 2. 58 419045 T85693 gb : yd60dO6. r1Soaresfetalliverspleen 1. 13 2. 08 443923 X60702 Hs. 210 bukocytetyrosinekinase 1. 11 2. 24 457585 AB040799 Hs. 278283 G protein-coupled receptor 27 1. 08 2. 04 452958 AA883929 Hs. 40527 ESTs 1. 03 2. 28 403969 ENSP00000034663 : Zinc finger protein 131 1. 00 2. 04 436878 BE465204 Hs. 47448 ESTs 1. 00 2. 12 415929 AA724373 Hs. 49344 hypothetical protein FLJ11006 1. 00 2. 18 404632 NM022490 : Homo sapiens hypothetical prot 1. 00 2. 19 452838 U65011 Hs. 30743 preferential expressed antigen in me ! a 1. 00 2. 35 447937 AL109716 Hs. 20034 Homo sapiens MRNA full length insert cDN 1. 00 2. 41 TABLE 62B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 431089 125941-2 OG940189 AW063489 AA715980 SFOO1091 BF880066 AA666102 AA621946 AA491826 456034 685586J AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE168945 432222 539529_1 BG207209 BE166299 Al204995 BG 199355 AW969908 AA528756 AW440776 B1044354

459702 539529_1 BG207209 BE 166299 Al204995 BG199355 AW969908 AA528756 AW440776 B1044354 414221 6855861 AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE168945 455657 1490185_1 BE065209 BE065364 BE065110 BE065111 419200 9531 1 BF036043 AW190446 BG194731 AW662036 AI445021 BE937550 AW818972 AW393132 AA834685 BF 112058 AV72 1682 H16423 Al 270167 Al857345 AA937302 AW818444 BE929780 BG498678 BF155010 81598271 B1599811 BE161728 AW578737 AW753711 AW379707 AW381918 BG506608 AW028637 AW994240 BF887392 BF790073 AW381624 AV727105 BF439618 AA443174 Ai018009 N42850 AW573242 A1417258 AA463483 A ! 676131 Al167170 M836627 M443828 AW592922 AA235129 AA730278 AW439062 AW474332 B1043239 AW474342 BG708553 AW362423 BF090028 BE827256 R16550 R39478 R39479 R94368 BG540916 BM314745 AA251087 D54231 D55274 BF085805 D31589 AW966405 AW994425 D81879 BE093545 AW901107 AA383529 Bl021552 R56420 N39976 AA573281 H82595 AA234955 BE093539 AW367006 BF358697 BF366318 AA663856 BE702099 BF035969 AI267384 AI267232 BE348320 AA621574 AA861212 BF083343 BF083341 AV745131 D53074 AW954476 AW954472 AA376836 AV724531 D53063 C14928 AA093287 AA062638 BG483558 BE940050 AA765954 T70171 BE938775 BE940057 D53502 AW373300 AL118798 BM128728 AA193411 AW444709 AW952455 AI887612 BF431948 BI496876 AI264159 BM128481 AI624657 AI689301 AI969467 AA861685 AA251595 AA625761 AA872090 AI826790 AA328366 BE827416 R75951 D56918 R68122 BE827384 ALt 18797 AIi84164 AA164411 81495332 BE858113 Api863860 H00660 T69849 AW780389 C14667 BE934995 Bai018652 R92801 AA164410 H00752 AW373305 AW373299 AW373302 430540 713_2 BC017171 BC012i95 NM 007t 26 AF10052 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418 BM045810 AU120387 BG770238 BG686740 BG913323 Bol759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 Al770171 BF196861 BE856897 AA463876 Al375927 AA648810 AA948193 AA490916 Al459893 Al458188 Al240408 Al191843 Al131029 AW768399 Api365196 AW337984 AW026150 BE466591 BE674599 A1818438 AA772197 A1651927 AW151143 B1198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 B1227204 BG761305 BE262642 BE391848 BE382475 BG008258 Bl547991 Bl459099 BE391391 BE259420 BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 Al435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 Al359493 BM018598 Al689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 Api421728 BG767231 BM462953 BG340524 W52648 AAl 13434 BE785431 81041981 BG83238 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 Bl091658 N72512 W58732 W85690 BG958989 Api205206 H19721 W17051 W77958 81262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 A1027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 A1243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 Al918399 Al537550 M491103 AW008188 R07703 AA9891 ZO AA746235 AW028983 AA789102 AU 185751 AW971465 AA489681 AW971893 AW612086 BE077936 Bol860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 434596 14701 1 AF147374 T59538 T59589 T59598 T59542 427289 1820_2 BC007350 BG766159 BG769338 BG761999 BG744385 BG770572 AW370610 AW370581 AA978353 AW327973 AW402425 Al889380 M868504 AW612968 AA630644 AI751211 N26980 AI394506 AA747849 BF154926 BF477185 AA649647 R39135 Api750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW370651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 Bl261497 Bl018403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 Bol018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340083 Z20199 400263 18977 1 Z11692 X51466 NM 001961 M19997 B1224253 BG830478 AU122147 AU123437 BG113591 BG752624 BE886804 81868669 8G337216 AW629935 BM016525 Al560409 AL562866 Al909178 BF849556 AA371735 BF038841 BF727115 BC006547 BG757526 AL555664 B1261304 BG770095 B1033486 Bol517580 BG876486 81011828 AI313235 B831724 BF869862 BG998348 Bol011834 BF888337 BF898627 BF092380 AW803215 F01241 BF805719 BG876487 AW498536 BF988866 BG998849 AA248724 BG829202 BG756456 BG032392 B1859287 BM016990 BG332369 BE933685 BE166758 BM452445 Api937808 AW026128 N23684 AW006041 At337621 F33111 BF344301 BG105450 BG387343 BF569547 BF154671 BM007368 BF569385 BE772007 Bol199487 BF761700 B12615i9 BF944452 BF898506 A1038390 BM044934 AW381142 Bu743618 BE769206 BE893973 Bol015047 BF886479 BF761350 BE769769 BG766117 BF847365 BE397834 AW371121 BF089125 BE082996 BF183193 BG180964 BF089940 B1000274 BG255503 BG674499 BG774174 bol015084 414580 623093_1 BG333973 BE385437 BE408833 BE387650 437026 1240260_1 AW976573 M742335 M830000 419045 348516_2 BF981324 BG723297 T85693 T81681 T81909 TABLE 62C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et al.'refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 404356 7630858 Minus 126433-126623 401116 9966559 Plus 123579-124447 404977 3738341 Minus 43081-43229 402181 8575912 Plus 449746-450040 405451 7622517 Minus 14594g146227 402217 9795981 Minus 21521-21757 406040 6758938 Minus 23063-23599 403532 8076842 Minus 81750-81901 402829 8918414 Plus 101532-101852, 102006-102263 403828 9838214 Plus 3175532148 405776 7159748 Minus 105911-107251 401963 3126783 Plus 51382-51521 402994 2996643 Minus 47274969 406016 8272661 Plus 41341-41940 402911 7263904 Plus 142689-142979 403960 8224409 Minus 90999-94843 406266 7528342 Minus 2365-2518 403803 8112965 Plus 55513-55778 404790 7230958 Plus 38611-38761 405318 3638954 Plus 79689-79967 402343 8099256 Plus 4677-6084 403986 8576059 Plus 90692-91238 401914 9369520 Plus 62537-62945, 63155-63308 402450 9796674 Plus 13753G137682, 137920-138045 404067 3282162 Plus 1415-2071 406368 9256126 Minus 72447-72588, 72673-72802, 73119-73245 400867 9838275 Plus 3413G34846 402605 9909420 Minus 47680-47973 403969 8569909 Plus 31237-31375, 32405-32506

404632 9796668 Plus 45096-45229 TABLE 63A : ABOUT 181 GENES UPREGULATED IN BENIGN NEVI RELATIVE TO MELANOMA METASTASES Table 63A lists about 181 genes upregulated in benign nevi relative to melanoma metastases. Genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 average of benign nevi Als divided by the 90th percentile of melanoma metastasis Als R2 average of benign nevi Ais divided by the 90th percentage of melanoma metastasis Als, where the 15th percentite of normal tissue Ais was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 401781 Target Exon 19. 33 19. 21 422511 AU076442 Hs. 117938 coliagen, bpeXVll, alpha1 13. 54 14. 18 401780 NM 00555r : Homo sapiens keratin 16 (foca 12. 97 13. 63 409601 AF237621 Hs. 80828 keratin 1 (epidemloy6c hyperkeratosisl 12. 61 31. 19 412636 NM-004415 desmoplal (in (DPI, DPII) 11. 73 6. 91 420783 AI659838 Hs. 99923 lectin. galactoside-binding, soluble, 7 10. 18 14. 08 409632 W74001 Hs. 55279 senne (or cysteiney proteinase inhibito 8. 48 6. 79 421733 AL119671 Hs. 1420 fibroblast growth factor receptor 3 (ach 8. 28 9. 62 430686 NM001942 Hs. 2633 desmoglein 1 7. 26 5. 64 429852 AB010445 Hs. 225948 small inducible cytokine subfamily A (Cy 7. 12 10. 88 442577 AA292998 Hs. 163900 ESTs 7. 01 6. 59 406964 M21305 FGENES predicted novel secreted protein 6. 50 8. 82 401785 NM002275' : Homo sapiens keratin 15 (KRT1 6. 40 9. 77 410001 AB041036 Hs. 57771 kallikrein 11 6. 18 6. 16 417515 L24203 Hs. 82237 ataxia-telangiectasiagroupD-associated 5. 73 16. 57 418686 Z36830 Hs. 87268 annexin A8 5. 32 5. 27 439496 BE616501 Hs. 32343 Homosapiens, SimilartoRIKENcDNA1110 4. 89 9. 81 452240 Api591147 Hs. 61232 ESTs 4. 89 6. 67 402525 NM002699' : Homo sapiens POU domain, clas 4. 74 4. 80 431360 NM000427 Hs. 251680 loricrin 4. 66 3. 98 431103 M57399 Hs. 44 Peiotrophin (heparin binding growth fac 4. 63 5. 69 418067 A1127958 Hs. 83393 cysta6n E/M 4. 56 6. 78 424012 AW368377 Hs. 137569 tumorprotein63kDawillhstronghomoloq 4. 56 5. 73 418663 AK001100 Hs. 41690 desmocollin 3 4. 44 5. 23 419329 AY007220 Hs. 288998 S100-type calcium binding protein A14 4. 24 6. 49 439706 AW872527 Hs. 59761 ESTs, Weakly similar to DAL-HUMAIN DEATH 3. 95 3. 37 421773 W69233 Hs. 112457 ESTs 3. 88 9. 60 408536 AW381532 Hs. 135188 ESTs 3. 82 10. 18 418394 AF132818 Hs. 84728 Knuppel-like/ætor5 (inteslinal) 3. 78 6. 33 408000 L11690 Hs. 198689 bullous pemphigoid anfigen 1 (230/240kD) 3. 77 4. 92 432374 W68815 Hs. 301885 HomosapienscDNAFLJ11346fis, clonePL 3. 70 5. 30 424049 AB014524 Hs. 138380 KIAA0624 protein 3. 68 4. 41 421948 L42583 Hs. 334309 keratin 6A 3. 62 3. 13 427666 Al791495 Hs. 180142 calmodulin-like skin protein (CLSP) 3. 59 4. 40 422168 AA586894 Hs. 112408 S100cåcium-bindingproteinA7 (psorias 3. 48 6. 09 436895 AF037335 Hs. 5338 carbonic anhydrase ! 3. 42 3. 28 437191 NM006846 Hs. 331555 serine protease inhibitor, Kazal type, 5 3. 28 3. 89 401760 Target Exon 3. 21 7. 11 431089 BE041395 ESTs, Weakly similar to unknown protein 3. 21 5. 78 434293 NM004445 Hs. 3796 EphB6 3. 14 3. 11 412432 AA126311 Hs. 9879 ESTs 3. 14 4. 85 442503 AF147078 Hs. 150853 p53responsive gene 5 3. 11 5. 92 414987 AA524394 Hs. 294022 hypothetical protein FW 14950 3. 07 4. 89 420798 W93774 Hs. 99936 keratin 10 (epidermolytc hyperkeratosis 2. 99 3. 09 433339 AF019226 Hs. 8036 glioblastoma overexpressed 2. 96 2. 75 414876 AW950925 Hs. 924 crystallin, mu 2. 94 3. 82 437233 D81448 Hs. 339352 Homo sapiens brother of CDO (BOC) mRNA, 2. 87 3. 42 424897 D63216 Hs. 153684 frizzled-related protein 2. 87 1. 96 456034 AW450979 gb : UI-H-BI3-ala-a-12-0-Ul. s1 NCI CGAP Su 2. 73 2. 54 424364 AW383226 Hs. 163834 ESTs, WeaklysimilartoG01763atrophin-2. 72 2. 92 427318 AF186081 Hs. 175783 zinc transporter 2. 71 2. 21 452887 Api702223 Hs. 107253 hypothetical protein DKFZp761F241 2. 67 6. 47 452308 A1167560 Hs. 61297 ESTs 2. 67 4. 61 407788 BE514982 Hs. 38991 S100 calcium-binding protein A2 2. 64 2. 68 431369 BE184455 Hs. 251754 secretoryleukocyteproteaeinhibitor (2. 57 3. 91 451541 BE279383 Hs. 26557 plakophilin 3 2. 49 5. 47 453317 NM 002277 Hs. 41696 keratin, hair, acidic, 1 2. 45 4. 17 412633 AF001691 Hs. 74304 periplakin 2. 42 4. 90 417233 W25005 Hs. 24395 small inducible cytokine subfamily B (Cy 2. 41 2. 68 424797 AA622394 Hs. 153177 hbosoma) protein S28 2. 39 2. 67 424010 AL080188 Hs. 137556 Homo sapiens mRNA ; cDNA DKFZp434A132 (fr 2. 39 4. 07 453241 H58995 Hs. 37648 ESTs 2. 39 2. 34 426451 A1908165 Hs. 169946 GATA-binding protein 3 (T-cell receptor 2. 36 1. 88 423467 AK000214 Hs. 129014 hypothetical protein FLJ20207 2. 32 2. 24 432222 Api204995 gb : anO3cO3. x1 Stratagene schizo brain S1 2. 31 1. 99 430168 AW968343 Hs. 145582 DKFZP43411735 protein 2. 30 2. 60 457121 Api743770 Hs. 180513 ESTS, Weakly similar to KIAA0822 protein 2. 28 1. 91

433091 Y12642 Hs. 3185 Iymphocyteantigen6complex, 10cusD 2. 27 8. 50 446989 AK001898 Hs. 16740 hypothetical protein FLJ11036 2. 27 2. 21 429365 AA451798 Hs. 99249 ESTs 2. 25 2. 54 459702 AI204995 gb : anO3cO3. x1 Stratagene schizo brain S1 2. 25 2. 35 420511 AF052692 Hs. 98485 gap junction protein, beta 3, 3lkD (conn 2. 23 2. 17 444946 AW139205 Hs. 156457 hypothetical protein FW22408 2. 23 3. 23 417017 AA976064 Hs. 180842 ribosome protein L13 2. 21 2. 74 433124 U51712 Hs. 13775 hypothetical protein SMAP31 2. 21 1. 68 430152 AB001325 Hs. 234642 aquaporin 3 2. 20 3. 32 444726 NM_006147 interferon regulatory factor 6 2. 15 5. 20 454034 NM_000691 Hs. 575 aldehyde dehydrogenase 3 family, member 2. 15 2. 82 425483 AF231022 Hs. 158159 FATtumorsuppessor (Drosophila) homoio 2. 14 2. 96 419912 AF249745 Hs. 6066 Rhoguaninenudeotide exchange factor) 2. 14 2. 25 431441 U81961 Hs. 2794 sodium channel, nonvoltage-gated 1 åpha 2. 12 2. 99 444105 AW189097 ESTs 2. 11 2. 98 428748 AW593206 Hs. 98785 Ksp37 protein 2. 09 1. 51 456826 A) 871742 Hs. 302428 vangless-type MMTV integraton site fami 2. 09 3. 25 413163 Y00815 Hs. 75216 protein tyrosine phosphatase, receptor t 2. 09 4. 97 410677 NM003278 Hs. 65424 tetranectin (plasminogen-binding protein 2. 06 5. 68 430285 Al917602 Hs. 106440 ESTs 2. 06 2. 04 444781 NM 014400 Hs. 11950 GPI-anchored metastasis-associated prote 2. 05 5. 92 451668 Z43948 Hs. 326444 cartilage acidic protein 1 2. 04 2. 19 441134 W29092 Hs. 346950 cellular retinoic acid-binding protein 1 2. 04 3. 08 433428 T29975 Hs. 33104 Hun6ngtin interacting protein C 2. 04 1. 63 425831 U46689 Hs. 159608 aldehyde dehydrogenase 3 tamily, member 2. 03 3. 92 446727 AB011095 Hs. 16032 KIAA0523 protein 2. 01 2. 60 431703 AA514264 Hs. 4437 triosephosphate isomerae 1 2. 01 2. 05 452554 AW452434 Hs. 58006 ESTs, Weakly similar to ALU5_HUMAN ALU S 1. 99 4. 04 439625 AF086453 Hs. 58611 ESTs 1. 99 2. 31 402880 Target Exon 1. 99 2. 75 428471 X57348 Hs. 184510 stratifin 1. 98 2. 10 413859 AW992356 Hs. 8364 Homo sapiens pyruvate dehydrogenase kina 1. 97 3. 16 452547 AA335295 Hs. 74120 adipose specific 2 1. 95 3. 89 437679 NM 014214 Hs. 5753 inositol (myo)-1 (or4)-monophosphatase2 1. 94 2. 06 429259 AA420450 Hs. 292911 Plakophilin 1. 93 2. 96 406387 Target Exon 1. 92 2. 97 455797 BE091833 gb : iL2-BT0731-260400-076-F04BT0731Homo 1. 91 3. 46 437202 AA326110 nuclear transcrip6on factor Y, gamma 1. 89 2. 00 426150 NM 003658 Hs. 167218 BarH-like homeobox 2 1. 86 2. 60 434574 A1424458 Hs. 33470 ESTs 1. 85 4. 61 446051 BE048061 Hs. 37054 ephrin-A3 1. 85 3. 48 424471 AA341329 Hs. 311524 ESTs 1. 84 2. 62 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 1. 83 4. 69 451721 NM 006946 Hs. 26915 spectrin, beta, non erythrocy6c 2 1. 82 2. 00 451849 Api199261 Hs. 27191 hypothetical protein from clone 24796 1. 81 2. 31 429348 AJ242859 Hs. 199731 Langerhans cell specific c-type lectin 1. 79 3. 07 423523 AW299828 Hs. 193580 ESTs 1. 77 3. 37 432543 AA552690 Hs. 152423 Homo sapiens cDNA : FLJ21274 fis, clone C 1. 76 2. 46 403828 C4000447' : gi) 7705570jref) NP038851. 1 ! Ki 1. 73 2. 06 412446 Api768015 ESTs 1. 68 3. 16 420039 NM004605 Hs. 94581 sulfotransferase family, cytosolic, 28, 1. 67 2. 22 411274 NM002776 Hs. 69423 kallikrein 10 1. 66 2. 26 401963 NM 00631 1 : Homo sapiens nuclear receptor 1. 66 2. 52 435016 A1284219 Hs. 130749 ESTs, Weakly similar to 138022 hypotheu 1. 65 2. 20 437897 AA770561 Hs. 146170 hypothetical protein FLJ22969 1. 64 3. 21 419648 T73661 Hs. 91877 thyroid hormone responsive SPOT14 (rat) 1. 63 2. 94 410545 U32324 Hs. 64310 interleukin 11 receptor, alpha 1. 62 2. 58 429211 AF052693 Hs. 198249 gap junction protein, beta 5 (connexin 3 1. 62 3. 92 456898 NM001928 Hs. 155597 D component of complement (adipsin) 1. 60 3. 43 423526 AB011086 Hs. 129739 KlM0514geneproduct 1. 60 2. 18 416305 AU076628 Hs. 79187 coxsackie virus and adenovirus receptor 1. 60 2. 47 413966 AA133935 Hs. 173704 ESTs, Moderately similar to A53959 throm 1. 59 2. 99 414217 AI309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 1. 59 2. 82 429299 A1620463 Hs. 347408 hypothetical protein MGC13102 1. 57 2. 64 432647 A ! 807481 Hs. 278581 fibroblast growth factor receptor 2 (bac 1. 56 2. 74 429002 AW248439 Hs. 2340 junction plakoglobin 1. 56 2. 97 430171 AF086289 Hs. 234766 skin-specific protein 1. 54 2. 18 422717 A1557623 Hs. 119475 cold inducible RNA-binding protein 1. 51 2. 19 414323 NM_014759 Hs. 334688 KIAA0273 gene product 1. 51 3. 73 423184 NM004428 Hs. 1624 ephrin-A1 1. 50 2. 18 433101 AW572317 Hs. 12082 Homo sapiens mRNA ; cDNA DKFZpS66L203 (fr 1. 50 2. 00 424362 AL137646 Homo sapiens mRNA : cDNA DKFZpS86F0824 (f 1. 48 2. 04 433662 W07162 Hs. 150826 RAB25 RAB25, member RAS oncogene family 1. 46 2. 83 445431 AF137386 Hs. 12701 plamolipin 1. 46 2. 00 456906 AF117646 Hs. 156637 Cas-Br-M (murinekectropicretroviråtr 1, 44 2. 04 442599 AF078037 Hs. 324051 ReIA-associated inhibitor 1. 42 3. 50 445656 W22050 Hs. 21299 ESTs, WeaklysimilartoAF1518401CGI-8 1. 42 2. 53 444672 Z95636 Hs. 11669 laminin, alpha 5 1. 40 2. 36 447990 BE048821 Hs. 20144 small inducible cytokine subfamily A (Cy 1. 40 2. 29 418462 BE001596 Hs. 85266 integdn, beta 4 1. 39 2. 86 453023 AW028733 Hs. 31439 serine protease inhibitor, Kunitz type, 1. 38 2. 28 416340 N31772 Hs. 79226 fasciculation and elongation protein zet 1. 38 2. 24 433417 AA587773 Hs. 8859 Homo sapiens, Similar to RIKEN cDNA 5830 1. 38 2. 14

407815 AW373860 Hs. 183860 hypothetical protein FLJ20277 1. 36 2. 34 432894 AW167668 Hs. 279772 brain specific protein 1. 36 5. 09 439733 AL365412 Hs. 107203 hypothetical protein from EUROIMAGE 1759 1. 36 2. 00 454478 AW805749 superoxide dismutase 2, mitochondrial 1. 35 2. 85 423515 AA327017 Hs. 176594 ESTs 1. 35 2. 45 436663 AW410458 Hs. 5258 chromosome 11 open reading frame2 1. 35 2. 07 404246 Target Exon 1. 34 2. 96 411939 A1365585 Hs. 146246 ESTs 1. 33 2. 31 409178 BE393948 Hs. 50915 kallikrein 5 1. 33 2. 03 427795 BE268268 Hs. 180842 nbosomal protein L13 1. 33 2. 29 447299 AF043897 Hs. 18075 chromosome 9 open reading frame 3 1. 32 2. 78 447330 BE279949 Hs. 18141 ladinin 1 1. 32 337 433399 N46406 Hs. 84700 similar to phosphatidylcholine transfer 1. 31 2. 71 403986 Target Exon 1. 31 2. 09 407597 AA043925 Hs. 339352 Homo sapiens brother of CDO (BOC) mRNA, 1. 30 2. 28 450796 NM_001988 Hs. 25482 envoplakin 1. 30 3. 45 415550 L13720 Hs. 78501 growth arrest-specific 6 1. 29 2. 76 415512 Y16270 Hs. 78482 paralemmin 1. 26 2. 49 430513 AJ012008 Hs. 241586 G6C protein 1. 26 3. 07 422581 NM 016339 Hs. 118562 Link guanine nucleotide exchange (actor 1. 23 2. 04 420048 AW206824 Hs. 25766 ESTs 1. 23 2. 01 425883 AL137708 Hs. 161031 Homo sapiens mRNA ; cDNADKFZp434K0322 (f 1. 23 2. 22 430560 Z28942 Hs. 243960 N-myc downstream-regulated gene 2 1. 23 2. 42 426377 AK001921 Hs. 169575 hypothetical protein MGC2550 1. 23 2. 20 402218 NM022165* : HomosapiensLin-7bprotein (1. 23 2. 01 413944 AW001579 Hs. 9645 Homo sapiens mRNA for KIAA1741 protein, 1. 18 2. 24 414186 U33446 Hs. 75799 protease, serine, 8 (prostasin) 1. 16 2. 16 426068 AF029778 Hs. 166154 jagged 2 1. 15 2. 07 431243 U46455 Hs. 252189 syndecan 4 (amphiglyean, ryudocan) 1. 14 2. 33 411388 X72925 Hs. 69752 desmocollin 1 1. 00 2. 61 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 1. 00 2. 63 TABLE 63B : Pkey : Unique Eos probeset identifier number CAT number : Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 412636 1438_1 M77830 NM 004415AF139065 BG681115 BG740377 BI712964 BG000656AA12B470 B1438324 H27408 BE931630 BE167165AW370827AW370813 J05211 BG698865 BG740734 BG680618 BG739778 Bl765807 BM353403 BM353248AW177784AW205789 AW951576AW848592 BE182164 BF149266 BE940187 81060445 B1060444 BF350983 BE720095 BE720069 BE715154 BE082584 BE082576 BE004047 AA857316 B1039774 BE713818 BE713548 AW170253 BE160433 B1039775 AW886475 BM462504 BE931734 BF149264 AA340777 BF381183 BG621737 AU127260 AW364859 BF993352 BG223489 BE819009 BF381184 BE715956 R58704 AA852212 AW366566 Bl090358 BF087707 BE819045 BE819005M377127 BE073467 BE819069 BE819048 81036306 BG990973 Bol040954 BF919911 AU140155Ai951766Al434518AW804674 BF752969BE837009 BE925826 BF149265 AW995615 BE814264 bol039782 AU140407 BEt44243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF086994 BF592276 BE082507 BE082514 BE082505 BF873693 AW068840 AW847678 BF804153 AW365157 BE813930 BE002030 AW365153 BE184941 BF749421 BE184920 BF839562 BE184933 BF842254 BE698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 W39488 C04715 BF096124 BE865341 AW799304 AL603116 BE149760 BE705967 BE705966 BE705968AW848723AW376699 AW376817AW376697 BG005097 BF751115 BE696084 AW848371 AW376782 AW848789 AW849074 AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 8GO05197 BF350086 BE715196 BE715155 BF752396 BF093817 BF831190 BF752409 BE006561 BG959922 BF094833 BF094748 8F094583 AW377699 AW607238 BE082519 AW377700 BF349467 AI190590 AI554403 AI392926 AUt 58477 BI467252 AU159919 AI760816 BF082516 AI439101 AA451923 AI340326 AI590975 BI791553 AI700963 A1142882 AA039975 AA946936 AA644381 BM314884 AA702424 A1417612 AW190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW166807 A1346078 W95070 AA149191 AA026864 A1830049 AW780435 A1078449 Al819984 Al858282 Bl468588 Al860584 A1025932 M026047 AA703232 AA658154 AA515500 AW 192085 AA918281 T77861 A1927207 Al205263 BF082491 AW021347 Al 568096 BE939862 M088866 D12062 AA056527 AA782109 W19287 W02156 AW150038 AA022701 T87181 H44405 A1910434 BF082513 A1494069 A1270027 A1635878M128330 BG681425 BE706078 R20904 BG680059 BG676647 BF764409 AA026654 AV745530 B1762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 AI571075 BE067786 AV721320 A1022862 N29754 C03378 N84767 AA131077 H30146 BE714290 Al686869 Al568892 Al915596 AW105614 Al887258 Al538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 A1905927 BF992780 AW853812 BG954443 B1770853 BG679406 BG740832 BG681087 BG698430 AA455100 T87267 BE696209 BE696210 B1089483 BE006273 BE872225 AW391912 BE925515 BG677012 BG741970 AA026480 BE705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 B1040941 AA337270 AW384371 AW847442 B1058659 BE813665 W95048 W25458 AW177786 AA025851 BE931733 BF154837 BG949393 BE714441 AW996245 BE711801 Api284090 BE064323 BE719390 BE940148 BG991212 BF375714 BF349522 BG996267 T48793 Bol013292 BE001925 AW365156 AW365154 AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W38382 Api498487 431089 1259412 BG940189AW063489AA715980BF0010916F880066AA666102AA621946AA49 1826 456034 685586 1 AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE168945 432222 539529 1 BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 B1044354 459702 539529 1 BG207209 BE166299 A1204995 BG199355 AW969908 AA528756 AW440776 81044354 444726 3503_2 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 A1745383 AU159045 A1693500 AW293668 AW371408 BE856107 A1338042 AW188320 At698246 BE673290 AW297653 AA156532 Al017342 Al916754 Ai190644 A1184302 M857671 BE857018 AI3W420 AI318157 AW204327 AW664668 AW274339 AA582788 A1345741 AW301433 A1873468 AW137388 BF718731 BF718413 AA877495 BF001575 A1824693 AW849604 AW849405 AW849396 AW849173 BE673179 AI611327 AA705753 BE715478 AW849414 AW849399 A1085759 AI140849 T67412 AI889885 AW104647 AI912495 AI889874 Ai744241 BE717113 BE717108 BE715564 AI872527 AA029457 C00338 AI469558 BE715577 AA045413 BF843813 444105 649788_1 AW189097AI123917AI123926 455797 1511159-1 BE091833 BE091874 BE091871 437202 27670_1 ALl 10199 ALS98719 AA152097 W84430 A1304351 BE670780 BF003019 A1271659 AW338914 A1127763 A1191873 A1922951 A1568416 A1077680 AA358674 AI138802 AI589W0 AI088745 AW418696 BF475830 AI144450 AA724257 AA622339 AI375884 AI880453 AW874251 BF941345 Api619746 Al225114 Al801268AI554474 BM023333AI093946 Al699306 Al803839 M496797 Al361531 Al123010 AW169313 BM023082 Al081626 M513457 AA278720 AW518810 AA361091 AI499891 AI686346 BF436872 AI681496 AL572961 AI334148 AW13829t AI419063 AA278226 AA370719 AA152023 Ai401749 AA127464 AL573761 BG913208 T07824 Ai346417 H44939 AV721378 N48299 W72005 AA302424 Ai611143 AW514684 BE041749

AW370992 R42918 H10757 R10703 C01061 R27637A1827230AW151953AA651675AA228006 AA233950 BE858910 R30801 W32704 H39784 BE090279 BG697660 AW877265 81818938 BF528291 AW953624 R57461 BF969694 412446 634671 BC021735 A1669212 AL120184 A1769949 BE701002 BE184363 BE819031 BG702238 BF090049 BF963318 BF961912 BF943013AA934514 AA151245 BF960659 AA987907 Z41449 BF908059 BF908053 BF908049 BE699424 BF908060 BF962832 BF952020 BF963134 B1035538 BF908052 BF908057 BF090026 BF943158 A1632924 BF512340 BF952021 BF960776 BF943437 BF942847 A1768015 F09778 F04816 F02721 AA102645 A1633838 AA617929 BF947001 B1035448 BE935876 AW890837 AW898604 BF957405 BF963433 BG704815 424362 2318_7 AF284421 AL137646 BG542551 Al278083 Al423919 Al274095 BE838965 BE839174 BE839102 BF924520 81913343 AW238809 AL134380 AW793289 AL534638 T97116 AW855182 C02210 AI783480 AW024874 454478 4273_16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 TABLE 63C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et a !.' refers to the publication entitled The DNA sequence of human chromosome 22"Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 401781 7249190 Minus 8321583435, 83531-83656, 83740-83901, 8423 401780 7249190 Minus 28397-28617, 28920-29045, 29135-29296, 2941 401785 7249190 Minus 165776-165996, 166189-166314. 166408-16656 402525 9800048 Minus 1974&20683 401760 9929699 Plus 83126-83250. 85320-85540, 94719-95287 402880 9926561 Minus 41555-41865 406387 9256180 Plus 116220-116371, 117512-117651 403828 9838214 Plus 31755-32148 401963 3126783 Plus 51382-51521 404246 7406725 Plus 82477-82628, 82721-82817, 82910-83071, 8314 403986 8576059 Plus 90692-91238 402218 7689783 Plus 127677-127886 TABLE 64A : ABOUT 929 GENES DOWNREGULATED IN PRIMARY MELANOMAS AND/OR MELANOMA METASTASES RELATIVE TO NORMAL SKIN Table 64A lists about 929 genes downregulated in primary melanomas and/or melanoma metastases relative to normal skin. Genes were selected from 59680 probesets on the Eos/Affymetrix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflecting the relative level of mRNA expression. Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 90th percent of normal skin Als divided by the 90th percentile of primary melanoma and melanoma metastasis Als R2 90th percentage of normal skin Als divided by the 90th percentile of primary melanoma and melanoma metastasis Als, where the 15th percentile of normal tissue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 420813 X51501 Hs. 99949 prolactin-induced protein 27. 72 20. 12 408591 AF015224 Hs. 46452 mammaglobin 1 26. 40 24. 26 431360 NM_000427 Hs. 251680 loricrin 26. 16 20. 45 401781 Target Exon 19. 68 19. 56 412636 NM_W4415 desmoplakin (DPl, DPII) 18. 12 10. 36 429441 AJ224172 Hs. 204096 lipophilin B (uteroglobin family member) 16. 61 18. 06 418067 A1127958 Hs. 83393 cystatin E/M 16. 00 25. 32 409632 W74001 Hs. 55279 serine (orcysteine) proteinaseinhibito 15. 64 11. 81 409601 AF237621 Hs. 80828 keratin 1 (epidermolytic hyperkeratosis) 15. 03 37. 51 401780 NM005557' : Homo sapiens keratin 16 (foca 14. 20 14. 86 422168 AA586894 Hs. 112408 S100 calcium-binding protein A7 (psodas 13. 95 28. 08 420783 AI659838 Hs. 99923 lec6n, galactoside-binding, soluble, 7 13. 52 18. 85 422511 AU076442 Hs. 117938 collagen, type XVII, alpha 1 13. 14 13. 81 428330 L22524 Hs. 2256 matrixmetalloproteinase7 (matrilysin, 12. 78 6. 35 421733 AL119671 Hs. 1420 fibroblast growth factor receptor 3 (ach 12. 78 15. 22 428824 W23624 Hs. 173059 ESTs 12. 67 13. 24 453309 Ai791809 Hs. 32949 defensin, beta 1 12. 02 12. 42 446227 A1281459 Hs. 270114 ESTs 11. 79 12. 32 421948 L42583 Hs. 334309 keratin 6A 11. 58 9. 02 432877 AW974111 Hs. 292477 ESTs 11. 18 11. 30 412047 AA934589 Hs. 49696 ESTs 11. 04 11. 07 407230 AA157857 Hs. 182265 keratin 19 10. 79 11. 40 421296 NM002666 Hs. 103253 perilipin 10. 73 7. 94 410001 AB041036 Hs. 57771 kallikrein 11 10. 72 10. 70 418026 BE379727 Hs. 83213 fatty acid binding protein 4, adipocyte 10. 33 7. 16 447966 AA340605 Hs. 105887 ESTs, Weakly similar to Homolog of rat Z 10. 09 9. 67 401203 Target Exon 9. 95 7. 37 452308 A1167560 Hs. 61297 ESTs 9. 71 20. 05 425580 L11144 Hs. 1907 galanin 9. 66 8. 41 433124 U51712 Hs. 13775 hypothetical protein SMAP31 9. 50 4. 96 420919 M57892 Hs. 100322 carbonic anhydrase Vl 9. 41 6. 34 443162 T49951 Hs. 9029 DKFZP434G032 protein 9. 36 10. 58 427666 AI791495 Hs. 180142 calmodulin-like skin protein (CLSP) 9. 19 11. 73 431369 BE184455 Hs. 251754 secretoryleukocyteproleaseinhibitor (8. 85 17. 76 408536 AW381532 Hs. 135188 ESTs 8. 82 26. 43 430686 NM 001942 Hs. 2633 desmoglein 1 8. 73 6. 58 436895 AF037335 Hs. 5338 carbonic anhydrase XII 8. 69 6. 81 418663 AK001100 Hs. 41690 desmocollin 3 8. 61 9. 15

429852 AB010445 Hs. 225948 small inducible cytokine subfamily A (Cy 8. 51 13. 13 424012 AW368377 Hs. 137569 tumor protein 63 kDa with strong homolog 8. 44 9. 61 430130 AL137311 Hs. 234074 HomosapiensmRNA ; cDNADKFZp761G02121 (8. 39 5. 13 442577 AA292998 Hs. 163900 ESTs 8. 34 7. 92 437191 NM 006846 Hs. 331555 serine protease inhibitor, Kazal type, 5 8. 16 10. 08 420859 AW468397 Hs. 100000 S100 calcium-binding protein A8 (calgran 8. 04 7. 55 413859 AW992356 Hs. 8364 Homo sapiens pyruvate dehydrogenase kina 7. 68 7. 81 452240 A1591147 Hs. 61232 ESTs 7. 63 9. 39 442757 A1739528 Hs. 28345 ESTs 7. 62 7. 31 450680 AF131784 Hs. 25318 Homosapiensclone25194mRNAsequence 7. 51 6. 17 456525 AW468397 Hs. 100000 S100 calcium-binding protein A8 (calgran 7. 49 7. 12 407328 AA508857 ESTs, Weakly similar to ALU 1 _HUMAN ALU S 7. 35 7. 20 414217 A1309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 7. 16 8. 39 417240 N57568 Hs. 48028 EST 7. 13 15. 05 410052 AA525225 Hs. 334630 Homo sapiens cDNA FLJ 14462 fis, clone MA 7. 13 7. 28 431842 NM 005764 Hs. 271473 epithelial protein up-regulated in carci 7. 06 6. 93 426488 X03350 Hs. 4 alcohol dehydrogenase 1 B (dass ), beta 7. 03 7. 85 439394 AA149250 Hs. 56105 ESTs 7. 00 4. 53 422963 M79141 Hs. 13234 ESTs 6. 99 5. 30 417515 L24203 Hs. 82237 ataxia-telangiectasia group D-associated 6. 97 20. 68 410530 M25809 Hs. 64173 ATPase, H transporting, lysosomal (vacuo 6. 96 7. 04 446989 AK001898 Hs. 16740 hypotheticalprotein FLJ11036 6. 96 6. 68 427890 AA435761 ESTs 6. 94 6. 68 432374 W68815 Hs. 301885 HomosapienscDNAFW11346fis, clonePL 6. 84 8. 44 429624 AA458648 Hs. 99476 ESTs, Weaklysimilarto1313184Bapha1 6. 83 6. 37 451029 AA852097 Hs. 25829 ras-related protein 6. 81 8. 96 408000 L11690 Hs. 198689 bullouspemphigoidan6gen1 (2301240kD) 6. 80 7. 68 439496 BE616501 Hs. 32343 Homo sapiens, Similar to RIKEN cDNA 1110 6. 77 14. 06 431713 AK000388 Hs. 267997 EHM2gene 6. 72 7. 11 451253 H48299 Hs. 26126 claudin 10 6. 71 7. 17 414987 AA524394 Hs. 294022 hypotheticalproteinFW14950 6. 67 11. 68 400304 AF005082 Hs. 113261 Homo sapiens skin-specific protein (xp33 6. 64 7. 90 408063 BE086548 Hs. 42346 calcineunn-binding protein calsarcin-1 6. 60 7. 29 424364 AW383226 Hs. 163834 ESTs, WeaklysimilartoG01763atrophin-6. 58 6. 78 421773 W69233 Hs. 112457 ESTs 6. 55 17. 59 425280 U31519 Hs. 1872 phosphoenolpyruvate carboxykinase 1 (sol 6. 55 6. 79 411388 X72925 Hs. 69752 desmocollin 1 6. 55 8. 97 401785 NM002275* : Homo sapiens keratin 15 (KRT1 6. 51 9. 94 406867 AA157857 Hs. 182265 keratin19 6. 50 6. 23 429504 X99133 Hs. 204238 lipocalin 2 (oncogene 24p3) (NGAL) 6. 43 6. 79 426106 Al678765 Hs. 21812 ESTs 6. 41 7. 69 413172 M38180 Hs. 38586 hydroxydelta-5-steroiddehydrogenae, 3 6. 39 7. 09 407395 AF005082 gb : Homo sapiens skin-specific protein (x 6. 39 7. 71 422166 W72424 Hs. 112405 S100calcium-bindingproteinA9 (calgran 6. 36 9. 23 437176 AW176909 Hs. 42346 calcineurin-binding protein calsarcin-1 6. 30 5. 45 440383 AA884208 Hs. 30484 ESTs 6. 26 6. 25 419329 AY007220 Hs. 288998 S100-type calcium binding protein A14 6. 22 10. 13 418686 Z36830 Hs. 87268 annexinA8 6. 19 6. 14 440116 A1798851 hemoglobin, gamma G 6. 18 4. 28 424049 AB014524 Hs. 138380 KIAA0624 protein 6. 18 6. 91 417366 BE185289 Hs. 1076 small proline-rich protein 1B (comifin) 6. 17 7. 42 432543 AA552690 Hs. 152423 Homo sapiens cDNA : FLJ21274 fis, clone C 6. 16 6. 86 414449 AA557660 Hs. 76152 decorin 6. 15 3. 93 441188 AW292830 Hs. 255609 ESTs 6. 12 6. 68 424008 R02740 Hs. 137555 putative chemokine receptor ; GTP-binding 6. 12 5. 33 431319 AA873350 Hs. 302232 ESTs 6. 11 6. 84 444105 AW189097 ESTs 5. 97 6. 20 428358 AA993222 Hs. 101915 Stargardt disease 3 (autosomat dominant) 5. 94 5. 15 407788 BE514982 Hs. 38991 5100 calcium-binding protein A2 5. 71 5. 83 439706 AW872527 Hs. 59761 ESTs, Weakly similar to DAP1HUMAN DEATH 5. 69 4. 49 428666 AL080190 Hs. 189242 HomosapiensmRNA ; cDNADKFZp434A202 (fr 5. 65 5. 16 410541 AA065003 Hs. 64179 syntenin-2 protein 5. 62 5. 84 431926 AW972724 gb : EST384816 MAGE resequences, MAGL Homo 5. 61 5. 75 430332 R51790 Hs. 239483 Human clone 23933 mRNA sequence 5. 60 5. 76 444946 AW139205 Hs. 156457 hypothetical protein FU22408 5. 53 9. 25 430714 AA484757 Hs. 287601 Homo sapiens cDNA FW 13830 fis, clone TH 5. 48 5. 38 435538 AB011540 Hs. 4930 low density lipoprotein receptor-related 5. 46 3. 19 414407 AA147026 Hs. 76704 ESTs 5. 43 5. 29 417035 AA192455 Hs. 22968 Homo sapiens clone IMAGE : 451939, mRNA se 5. 40 5. 40 442315 AA173992 Hs. 7956 ESTs, ModeratelysimilartoZN91_HUMANZ 5. 40 3. 87 416931 D45371 Hs. 80485 adipose most abundant gene transcript 1 5. 39 9. 12 431048 R50253 Hs. 249129 cell death-inducing DFFA-like effector a 5. 39 6. 06 436090 At640635 Hs. 332879 EST 5. 37 5. 33 411274 NM 002776 Hs. 69423 kallikrein 10 5. 37 5. 97 418394 AF132818 Hs. 84728 Kruppel-like factor 5 (intestinal) 5. 36 9. 35 406706 X03740 Hs. 231581 myosin, heavy potypepfide 1, skeletal mu 5. 34 4. 08 430171 AF086289 Hs. 234766 skin-specific protein 5. 32 10. 40 452747 BE153855 Hs. 61460 lg superfamily receptor LNIR 5. 31 6. 01 426451 A1908165 Hs. 169946 GATA-binding protein 3 (T-cell receptor 5. 31 3. 81 414602 AW630088 Hs. 76550 HomosapiensmRNA ; cDNADKFZp564B1264 (f 5. 26 5. 92 424399 A1905687 A1905687 : IL-BT095-190199-019 BT095 Homo 5. 25 16. 94 430071 AA355986 Hs. 232068 transcription factor 8 (represses inter) 5. 20 5. 01 431416 AA532718 Hs. 178604 ESTs 5. 18 5. 38

420039 NM 004605 Hs. 94581 suliotransferaetamily, cytosolic, 2B, 5. 17 5. 72 446082 A1274139 Hs. 156452 ESTs 5. 16 5. 14 430699 AW969847 Hs. 292718 ESTs. WeaklysimilartoRET2 HUMANRETIN 5. 14 4. 97 434625 W01370 Hs. 46824 ESTs 5. 12 6. 18 426101 AL049987 HomosapiensmRNA ; cDNADKFZp564F112 (fr 5. 11 3. 79 419648 T73661 Hs. 91877 thyroid homwne responsive SPOT14 (rat) 5. 08 13. 64 438962 BE046594 gb : hn41c11. x1 NCI CGAP RDF2 Homo sapiens 5. 08 4. 09 419912 AF249745 Hs. 6066 Rho guanine nucleotide exchange factor (5. 08 4. 77 420583 H77859 Hs. 65450 reticulon 4 5. 06 5. 56 432125 AW972667 Hs. 183006 Homo sapiens cDNA FLJ 12300 fis, clone MA 5. 05 6. 32 445263 H57646 Hs. 42586 KIAA1560 protein 5. 03 5. 22 407839 AA045144 Hs. 161566 ESTs 5. 03 5. 27 434293 NM 004445 Hs. 3796 EphB6 5. 03 4. 91 427850 AA416756 Hs. 161051 ESTs, Moderately similar to ALU6HUMAN A 4. 99 16. 04 414657 AA424074 Hs. 76780 protein phosphatase 1, regulatory (inhib 4. 94 8. 14 445493 A1915771 metallothioneintE (functional) 4. 93 4. 33 429365 AA451798 Hs. 99249 ESTs 4. 90 5. 19 412633 AF001691 Hs. 74304 periplakin 4. 90 11. 71 448490 Al523897 Hs. 271692 ESTs, Weakly similar to 138022 hypothe6 4. 85 4. 88 408491 A1088063 Hs. 7882 ESTs 4. 80 4. 39 430168 AW968343 Hs. 145582 DKFZP43411735 protein 4. 80 6. 05 407102 AA007629 glycerol-3-phosphate dehydrogenase 1 (so 4. 78 7. 23 421998 R74441 poly (A)-binding protein, nuclear 1 4. 77 4. 78 422633 X56832 Hs. 118804 eno) ase3. (beta. musde) 4. 72 6. 24 444930 BE185536 Hs. 301183 moiecuie possessing ankyrin repeats indu 4. 71 3. 72 439652 W67826 Hs. 55412 ESTs, Weakiy simila to K1CJ_HUMAN KERAT 4. 70 3. 60 450626 AW190989 Hs. 1508 insulin-degrading enzyme 4. 68 5. 14 456898 NM001928 Hs. 155597 D component of complement (adipsin) 4. 68 15. 83 408239 Au053401 ESTs, Moderately similar to ALU7 HUMAN A 4. 67 6. 17 415192 D17793 Hs. 78183 aldo-keto reductase family 1, member C3 4. 64 4. 48 443827 A1087867 Hs. 134667 ESTs 4. 63 5. 06 431441 U81961 Hs. 2794 sodium channel, nonvoltage-gated 1 alpha 4. 63 8. 48 408741 M73720 Hs. 646 carboxypeptidaeA3 (matcell) 4. 63 3. 19 427318 AF186081 Hs. 175783 zinc transporter 4. 62 3. 57 453767 AB011792 Hs. 35094 extracellular matrix protein 2, female o 4. 62 5. 14 424046 AF027866 Hs. 138202 senne (orcysteine) proteinaseinhibito 4. 61 6. 80 437233 D81448 Hs. 339352 Homo sapiens brother of CDO (BOC) mRNA, 4. 60 6. 19 446525 AW967069 Hs. 211556 hypothetical protein MGC5487 4. 59 2. 45 402294 Target Exon 4. 57 5. 47 424098 AF077374 Hs. 139322 small proline-rich protein 3 4. 57 5. 12 420798 W93774 Hs. 99936 keratin 10 (epidermolytichyperkeratosis 4. 57 4. 76 418021 M15881 Hs. 1137 uromodulin (uromucoid, Tamm-Horsfall gly 4. 54 4. 49 422068 A1807519 Hs. 104520 Homo sapiens cDNA FW13694 fis, clone PL 4. 54 4. 32 414798 A1286323 Hs. 97411 hypothetica protein MGC12335 4. 53 3. 04 410132 Nom003480 Hs. 300946 Microfibril-associated glycoprotein-2 4. 53 2. 91 400109 Eos Control 4. 52 3. 94 407242 M18728 gb : Human nonspecific crossreacbng antg 4. 51 4. 07 431901 AW295050 Hs. 272023 transforming, acidic coiled-coil contain 4. 50 4. 16 435992 A1033259 Hs. 118317 HomosapienscDNAFW12088fis, cloneHE 4. 50 4. 77 447365 BE383676 Hs. 334 Rho guanine nucleotide exchange factor (4. 50 3. 99 449785 A1225235 Hs. 288300 hypothetical protein FU23231 4. 49 4. 02 424620 AA101043 Hs. 15 1254 kallikrein 7 (chymotrypuc, stratum com 4. 47 5. 43 432559 AW452948 Hs. 257631 ESTs 4. 47 3. 10 459290 NM001546 Hs. 34853 inhibitorofDNAbinding4, dominantneg 4. 45 3. 17 422313 AF045941 Hs. 115166 sciellin 4. 45 5. 07 416305 AU076628 Hs. 79187 coxsækievirusandadenovinusreceptor 4. 44 5. 25 432314 AA533447 Hs. 312989 ESTs 4. 44 3. 52 441633 AW958544 Hs. 112242 normal mucosa of esophagus specific 1 4. 43 2. 64 424670 W61215 Hs. 116651 epithelial V-like antigen 1 4. 42 4. 27 414489 A1620677 Hs. 73105 ESTs 4. 41 3. 77 413040 AA193338 Hs. 12321 sodium calcium exchanger 4. 36 4. 58 426974 AB002298 Hs. 173035 KIAA0300 protein 4. 35 4. 97 448249 AW855331 Hs. 337124 ESTs 4. 35 4, 49 451743 AW074266 Hs. 23071 ESTs 4. 34 4. 52 427919 AA173942 Hs. 326416 Homo sapiens mRNA ; cDNADKF2p564H19I6 (f 4. 33 3. 94 422305 Al928242 Hs. 293438 ESTs, HighlysimilartoAFl984881trans 4. 32 7. 20 408104 AW972927 Hs. 293968 ESTs 4. 31 3. 53 447945 A1922838 Hs. 9670 ESTs, Weakly similar to ALU1 HUMAN ALU S 4. 30 3. 72 439349 A1660898 Hs. 6834 ESTs 4. 29 4. 16 433339 AF019226 Hs. 8036 glioblastoma overexpressed 4. 29 3. 94 427074 AA527435 Hs. 178589 hepatocellularcancinomaantigengeneS2 4. 28 4. 97 453574 Api767947 Hs. 50841 ESTs 4. 25 3. 66 410677 NM003278 Hs. 65424 tetranectin (plasminogen-binding protein 4. 25 17. 64 424833 NM 003894 Hs. 153405 period (Drosophila) homo) 2 4. 22 3. 13 426248 T18988 Hs. 293668 ESTs 4. 21 4. 09 410480 R97457 Hs. 63984 cadherin 13, H-cadherin (heart) 4. 19 2. 76 406805 A1686003 Hs. 296031 ESTs 4. 19 3. 87 438533 A) 440266 Hs. 170673 ESTs, Weakly similar to T24832 hypotheii 4. 18 5. 93 451831 NM 001674 Hs. 460 activating transcription factor 3 4. 18 4. 74 431211 M86849 Hs. 323733 gap juncton protein, beta 2, 26kD (conn 4. 17 2. 83 434936 A1285970 Hs. 183817 ESTs 4. 17 4. 39 430361 A1033965 Hs. 239926 sterol-C4-methyl oxidase-like 4. 17 2. 38 448429 D17408 Hs. 21223 calponin 1, basic, smooth muscle 4. 16 5. 15

421978 AJ243662 Hs. 110196 NICE-1 protein 4. 15 8. 07 437135 AL038624 Hs. 208752 EsTsweaklysimilartoALu8 HUMANALUS 4. 14 4. 92 442554 AW467376 Hs. 129640 ESTs 4. 12 4. 00 451814 AA847992 Hs. 137003 ESTs 4. 11 4. 58 410023 AB017169 Hs. 57929 slit (Drosophila) homolog 3 4. 10 3. 92 457121 A1743770 Hs. 180513 ESTs, Weakly similar to KIAA0822 protein 4. 09 3. 19 426539 AB011155 Hs. 170290 discs, large (Drosophila) homolog 5 4. 09 3. 69 430191 A1149880 Hs. 188809 ESTs 4. 07 4. 49 430433 AA478883 Hs. 273766 ESTs 4. 07 3. 74 425992 AA367069 Hs. 100636 ESTs 4. 06 4. 37 428931 AA994979 Hs. 98967 ATPase. H ()-transporting, lysosomal, non 4. 05 4. 15 452392 L20815 Hs. 507 comeodesmosin 4. 04 11. 00 402845 ENSP00000246267 : KIAA0444 PROTEIN (FRAGME 4. 03 4. 18 439873 8E159253 Hs. 300638 ESTs 4. 03 3. 86 432305 M62402 Hs. 274313 insulin-like growth factor binding prote 4. 02 8. 79 420789 Al670057 Hs. 199882 ESTs 4. 02 4. 34 453560 AA348626 Hs. 5890 hypothetical protein FLJ23306 4. 02 5. 13 428957 NM_00388t Hs. 194679 WNTt inducible signaling pathway protein 4. 01 4. 29 429556 AW139399 Hs. 98988 ESTs 4 01 448585 AB020676 Hs. 21543 KIAA0869 protein 4. 01 4. 52 403710 C4000160 : gi12735793pefXP 011928. 1 pr 4. 00 3. 31 423634 AW959908 Hs. 1690 heparin-bindinggrowthfactorbindingpr 3. 98 6. 61 421485 AA243499 Hs. 104800 hypothetical protein FU10134 3. 98 3. 79 437611 AA897108 gb : amO8aO6. s1Soares_NFL_T_GBC_S1Homos 3. 97 4. 24 426500 NM014638 Hs. 170156 KIAA0450 gene product 3. 96 4. 93 448710 T62926 Hs. 304184 ESTs 3. 96 4. 54 408199 AA132637 Hs. 15396 Homo sapiens, done IMAGE : 3948909, mRNA, 3. 95 5. 57 428340 AF261088 Hs. 154721 aconitase 1, soluble 3. 94 3. 24 410197 NMM005518 Hs. 59889 3hydroxy-3-methylglutaryl-Coenzyme A sy 3. 94 9. 16 456972 A1054347 Hs. 2017 ribosomal protein L38 3. 93 4. 37 418381 AA682393 Hs. 119237 ESTs 3. 93 3. 45 444781 NM_014400 Hs. 11950 GPI-anchored metastasis-associated prote 3. 92 15. 00 456332 AA228357 gb : nc39dO5. r1 NCl_CGAP Pr2Homosapiens 3. 91 4. 88 445607 AA488107 Hs. 30156 ESTs, Weakly similar to unnamed protein 3. 91 3. 19 426411 AK000708 Hs. 169764 hypothetical protein FU20701 3. 90 4. 50 446733 AA863360 Hs. 26040 ESTs, Weakly similar to fatty acid omega 3. 90 3. 89 442498 U54617 Hs. 8364 Homo sapiens pyruvate dehydrogenase kina 3. 89 5. 11 452894 A1598065 Hs. 61558 ESTs 3. 88 3. 73 430570 Al417681 Hs. 292464 ESTs 3. 87 4. 47 439625 AF086453 Hs. 58611 ESTs 3. 86 4. 81 418793 AW382987 Hs. 88474 prostaglandin-endoperoxide synthase t (p 3. 85 3. 01 431247 AL, 021578 Hs. 278489 matnlin 4 3. 85 3. 35 426350 NM3245 Hs. 2022 transglutaminase (Epoiypeptide. prote 3. 85 5. 15 441319 A1354869 Hs. 133081 ESTs, Weakly similar to T08700 hypotheti 3. 84 5. 03 452877 A1250789 Hs. 32478 ESTs 3. 84 3. 26 444252 R21135 Hs. 54985 ESTs 3. 83 5. 58 416265 AA177088 Hs. 190065 ESTs 3. 82 3. 87 418875 W19971 Hs. 233459 ESTs 3. 80 2. 92 440509 BE410132 Hs. 134202 ESTs, Weakly similar to T17279 hypotheti 3. 80 4. 36 442503 AF147078 Hs. 150853 p53-responsive gene 5 3. 80 7. 53 427081 A1474533 Hs. 170528 ESTs, Moderate simitar to ALUC HUMAN ! 3. 77 4. 81 458222 AW139592 hypothetical protein DKFZp434K1421 3. 77 3, 56 445107 Al208121 Hs. 147313 ESTs, Weaklysimilartol38022hypolheti 3. 77 3. 20 436283 A1480319 Hs. 120058 ESTs 3. 76 3. 76 436557 W15573 Hs. 5027 ESTs, Weakly similar to A47582 B-cell gr 3. 76 2. 65 448988 Y09763 Hs. 22785 gamma-aminobutyhcacid (GABA) A recepto 3. 75 7. 59 434206 AW136973 ESTs, Weakly similar to S69890 mitogen i 3. 72 3. 96 424824 A1217440 Hs. 143873 ESTs 3. 72 3. 52 457411 AW085961 Hs. 130093 inxjuois-classhomeoboxproteinlRX2 3. 71 3. 05 452241 AL050204 Hs. 28540 HomosapiensmRNA ; cDNADKFZp586F1223 (f 3. 70 4. 84 421845 AW021631 Hs. 16515 ESTs 3. 69 3. 59 413922 A1535895 Hs. 221024 ESTs 3. 68 4. 22 422746 NM 004484 Hs. 119651 glypican 3 3. 68 4. 29 433934 AW273261 Hs. 216292 ESTs 3. 68 4. 39 452547 AA335295 Hs. 74120 adipose specific 2 3. 66 12. 23 400295 W72838 AI905687 : IL-BT095-90199-019 BT095 Homo 3. 66 9. 25 419098 AA234041 Hs. 87271 ESTs 3. 66 4. 94 417054 AF017060 aldehyde oxidase 1 3. 65 4. 51 423974 AL118754 gb : DKFZp761P1910g1761 (Synonym : hamy2) 3. 65 4. 32 431362 A1874223 Hs. 293560 ESTs 3. 65 3. 73 420506 AW977779 Hs. 194613 ESTs 3. 65 3. 25 448065 A1459177 Hs. 172759 ESTs, Moderately similar to ALU7 HUMAN A 3. 64 4. 62 437457 AA757900 Hs. 270823 ESTs. Weakly similar to S65657 alpha-lc, 3. 64 4. 54 451951 AW082870 Hs. 210954 ESTs 3. 64 3. 69 436679 Al127483 Hs. 120451 ESTs, Weaklysimilartounnamedprotein 3. 64 3. 39 412676 NM_000165 Hs. 74471 gapjunctonprotein, alpha1, 43kD (con 3. 62 3. 62 412668 AA456195 hypothetical protein FLJ14621 3. 62 4. 22 413899 AF083892 Hs. 75608 tight junction protein 2 (zonaocdudens 3. 62 3. 06 444726 NM 006147 interferon regulatory factor 6 3. 59 10. 65 428722 U76456 Hs. 190787 Ossue inhibitor of metalloproteinase 4 3. 59 3. 31 429973 A1423317 Hs. 164680 ESTs 3. 59 3. 71 452413 AW082633 Hs. 215030 ESTs 3. 58 4. 66 416157 Nom003243 Hs. 342874 transforming growth factor, beta recepto 3. 58 4. 44

430397 A1924533 Hs. 105607 bicarbonate transporter related protein 3. 57 3. 74 411939 A1365585 Hs. 146246 ESTs 3. 57 12. 42 450353 Api244661 Hs. 103296 ESTs, Weakly similar to S65657 alpha-1 G 3. 57 4. 11 432406 Api340571 Hs. 343666 KIAA0969 protein 3. 57 2. 84 439609 AW971945 Hs. 293236 ESTs 3. 56 3. 14 435381 AW136397 Hs. 175382 ESTs 3. 56 3. 48 410173 AA706017 Hs. 119944 ESTs 3. 56 3. 37 414002 NM006732 Hs. 75678 FBJ murine osteosarcoma viral oncogene h 3. 56 9. 93 413305 NM_000426 Hs. 323511 Homo sapiens cDNA : FLJ23176 fis, clone L 3. 55 4. 24 434360 AW015415 Hs. 127780 ESTs 3. 55 4. 77 423973 AF038461 Hs. 136574 arachidonate 12-lipoxygenase, 12R type 3. 53 5. 65 425681 AB018297 Hs. 159183 KIAA0754 protein 3. 52 4. 79 428382 AF007132 Hs. 184019 Homo sapiens clone 23551 mRNA sequence 3. 51 4. 46 451184 T87943 transcription factor 7-like 2 (T-cell sp 3. 51 3. 63 448496 BE379077 Hs. 130849 ESTs, Weakly similar to 138022 hypotheti 3. 51 3. 30 425831 U46689 Hs. 159608 aldehyde dehydrogenase 3 family, member 3. 48 8. 66 428232 BE272452 Hs. 183109 monoamine oxidase A 3. 48 9. 54 425483 AF231022 Hs. 158159 FAT tumor suppressor (Drosophila) homolo 3. 48 6. 05 401760 Target Exon 3. 48 7. 86 427899 AA829286 Hs. 332053 serum amyloid A1 3. 47 3. 67 451767 A1625014 Hs. 187328 ESTs 3. 46 3. 85 452849 AF044924 Hs. 30792 hook2 protein 3. 45 5. 66 427408 AA583206 Hs. 2156 RAR-related orphan receptor A 3. 45 5. 02 447165 AL042400 Hs. 75668 Homo sapiens, Similar to RIKEN cDNA 1700 3. 45 3. 61 422083 NM 001141 Hs. 111256 aræhidonate15iipoxygenae, secondbp 3. 45 7. 71 420876 AA918425 Hs. 177744 ESTs 3. 44 8. 46 421114 AW975051 Hs. 293156 ESTs, Weaklysimilartol78885serine/th 3. 44 4. 47 426233 AA372796 Hs. 269339 ESTs, Weakly similar to AF1613561HSPCO 3. 44 3. 96 428221 U96781 Hs. 183075 ATPase, Ca transporting, cardiac muscle. 3. 42 4. 32 403593 Target Exon 3. 42 6. 35 423467 AK000214 Hs. 129014 hypothetical protein FLJ20207 3. 42 3. 34 447731 AA373527 Hs. 19385 CGI-58 protein 3. 41 2. 44 456327 H68741 Hs. 38774 ESTs 3. 40 3. 46 413880 A1660842 Hs. 110915 interleukin 22 receptor 3. 37 3. 61 429501 A1700588 Hs. 293388 ESTs, Weakly similar to A34612 zinc ftng 3. 37 3. 44 437575 AW954355 Hs. 36529 hypothetical protein MGC11242 3. 36 4. 87 420231 R06866 Hs. 19813 ESTs 3. 36 8. 60 424010 AL080188 Hs. 137556 Homo sapiens mRNA ; cDNA DKFZp434A132 (fr 3. 36 6. 20 426789 F06596 Hs. 23837 HomosapienscDNAFLJ11812fis, cloneHE 3. 34 3. 40 434274 AA628539 Hs. 116252 ESTs, ModeratelysimilartoALU1 HUMANA 3. 34 3. 35 420693 NM 001972 Hs. 99863 elastase 2, neutrophil 3. 34 4. 06 418318 U47732 Hs. 84072 transmembrane 4 superfamily member 3 3. 33 4. 36 413163 Y00815 Hs. 75216 protein tyrosine phosphatase, receptor t 3. 32 9. 47 428496 AA769986 Hs. 185802 ESTs 3. 32 3. 88 416349 X69089 Hs. 79227 myomesin (M-protein) 2 (165kD) 3. 31 4. 01 409095 AW337272 Hs. 293656 ESTs, Moderately similar to S72481 proba 3. 31 3. 31 443072 A1937532 gb : wp78d02. x1 NCI CGAP Bm25 Homo sapien 3. 31 4. 40 437596 AA761490 ESTs, Moderately similar to S65657 alpha 3. 30 5. 31 444094 A1695764 Hs. 202394 ESTs 3. 29 3. 47 437150 R51407 Hs. 77910 3-hydroxy-3methylglutayl-CoenzymeAsy 3. 29 3. 76 407334 AA494411 Hs. 296031 ESTs 3. 28 4. 30 423017 AW178761 Hs. 227948 senne (or cysteine) proteinase inhibito 3. 28 3. 78 447875 R22029 Hs. 13905 ESTs 3. 28 3. 44 418969 W33191 Hs. 28907 hypothetical protein FU20258 3. 27 3. 71 411962 AA099050 gb : zk85d12. r1SoarespregnantuterusNbH 3. 27 4. 28 424395 AA165082 Hs. 146388 microtubule-associated protein 7 3. 27 3. 82 400494 ENSPOO000238970* : CIG30 (Fragment). 3. 27 2. 60 430418 R98852 Hs. 36029 heart and neural crest derivatives expre 3. 26 6. 19 409231 AA446644 Hs. 692 GA733-2 antigen ; epithelial glycoprotein 3. 26 4. 24 434952 T10269 Hs. 4285 Homo sapiens cDNA : FLJ22505 fis, clone H 3. 26 5. 17 445234 AW137636 Hs. 146059 ESTs 3. 25 5. 59 426150 NM_003658 Hs. 167218 BarH-like homeobox 2 3. 25 5. 21 400076 Eos Control 3. 25 3. 60 421462 AF016495 Hs. 104624 aquaporin 9 3. 25 3. 93 420677 AW086215 Hs. 246096 ESTs 3. 25 3. 53 424125 M31669 Hs. 1735 inhibin, beta B (acfivin AB beta polypep 3. 24 3. 88 443672 AA323362 Hs. 9667 butyrobetaine (gamma), 2-oxoglutarate di 3. 24 5. 64 420682 Api380552 Hs. 88602 ESTs 3. 24 4. 13 423725 AJ403108 Hs. 132127 hypothetica) protein LOC57822 3. 23 4. 90 431157 A1823969 Hs. 132678 ESTs 3. 23 3. 97 440469 AA886068 gb : ny40eO7. s1 NCl_CGAP_Pr12Homosapiens 3. 23 3. 39 449961 AW265634 Hs. 133100 ESTs 3. 21 5. 36 407948 AW085161 Hs. 56279 ICEBERG caspase-1 inhibitor 3. 21 4. 61 400835 chromosome 2 open reading frame 2 3. 21 3. 62 413329 A1056885 Hs. 133539 ESTs 3. 21 3. 43 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian 3. 21 3. 72 450860 AA021007 integdn, beta 8 3. 20 5. 89 444816 Z48633 Hs. 283742 H. sapiensmRNAforetrotransposon 3. 19 6. 84 453855 AA039576 Hs. 37858 ESTs, WeaklysimilartoALUB_HUMAN ! ! ! ! 3. 19 3. 59 432278 AL137506 Hs. 274256 hypothefical protein FLJ23563 3. 19 3. 51 420074 AA253425 Hs. 190074 ESTs 3. 18 5. 50 418481 M81945 CD34 antigen a18 3. 65 408522 A1541214 Hs. 46320 Small proline-rich protein SPRK (human, 3. 18 7. 43

435337 A1078307 Hs. 134317 ESTs, WeaklysimilartoPC4259fenitin 3. 17 3. 51 445502 AW379160 Hs. 12813 DKFZP434J214 protein 3. 17 3. 62 412477 AA150864 micnDsomå glutathione S-transferase 1 3. 17 5. 39 421757 Z20897 Hs. 296259 paraoxonase 3 3. 16 3. 60 413835 A1272727 Hs. 249163 fatty acid hydroxylae 3. 16 5. 56 420309 AW043637 Hs. 21766 ESTs, Weakly similar to ALUS HUMAN ALU S 3. 15 1. 99 444895 Api674383 Hs. 22891 solute carder family 7 (cationic amino 3. 15 4. 45 414869 AA157291 Hs. 21479 ubinuclein 1 3. 13 4. 40 412947 AA122277 gb : zk97e09. s1 Soares_pregnant_utenus_NbH 3. 13 3. 30 443265 Api916207 Hs. 9167 SH3 domain binding glutamic acid-rich pr 3. 12 4. 62 421335 X99977 Hs. 103505 ARScomponentB 3. 11 11. 54 401905 ENSPOOOW252232 : Sterol regulatory eleme 3. 10 2. 85 443514 BE464288 Hs. 141937 ESTs 3. 09 3. 66 418817 AA913229 Hs. 19339 ESTs 3. 08 3. 88 434727 H43374 Hs. 7890 Homo sapiens mRNA for KIAA1671 protein, 3. 08 4. 18 435858 AF254260 Hs. 283009 tuftelin 1 3. 08 3. 96 430285 A1917602 Hs. 106440 ESTs 3. 07 3. 30 448106 Al800470 Hs. 171941 ESTs 3. 07 5. 19 432908 A1861896 ESTs 3. 07 3. 85 450086 AW016343 Hs. 233301 ESTs 3. 07 3. 38 451529 A1917901 Hs. 208641 ESTs 3. 07 3. 29 418443 Nom-005239 Hs. 85146 v-etsavianerythroblastosisvinusE260 3. 06 4. 12 426848 H72531 Hs. 36190 ESTs 3. 05 4. 34 429506 D49835 Hs. 171942 ras responsive element binding protein 1 3. 05 3. 97 425955 T96509 Hs. 248549 ESTs, Moderately similar to S65657 alpha 3. 05 3. 29 413822 R08950 Hs. 272044 ESTs, Weakly similar to ALU1 HUMAN ALU S 3. 05 3. 89 434230 AA551569 hypothetical protein PR02822 3. 04 3. 63 453655 AW960427 Hs. 342874 transforming growth factor, beta recepto 3. 04 8. 09 415696 A1821552 Hs. 188682 ESTs 3. 03 3. 43 449618 A1076459 Hs. 15978 KIAA1272 protein 3. 01 3. 29 414665 AA160873 serum amyloid A1 3. 01 9. 22 446682 AW205632 Hs. 211198 ESTs 3. 00 3. 30 443801 AW206942 Hs. 253594 intron of : trichorhinophaiangeasyndro 299 3. 74 412446 A1768015 ESTs 2. 99 4. 47 449271 AW338067 Hs. 7869 Homo sapiens cDNA FLJ 11946 fis, clone HE 2. 99 4. 35 435702 A1033647 Hs. 121001 Homo sapiens, clone IMAGE : 3460280, mRNA 2. 98 3. 49 403180 Target Exon 2. 98 3. 92 434442 AA737415 ESTs 2. 98 3. 61 439593 BE073597 Hs. 124863 ESTs 2. 98 3. 86 410453 AW749036 gb : RC2-BT031&241193011-f10 BT0318 Homo 2. 98 3. 49 414766 AW293452 Hs. 16228 ESTs 2. 97 3. 63 432566 AW439330 Hs. 256889 ESTs, Weakly similar to 2109260A B cell 2. 97 3. 99 451541 BE279383 Hs. 26557 plakophilin 3 2. 97 6. 90 452195 AA994712 Hs. 116878 ESTs 2. 97 3. 30 401747 Homo sapiens keratin 17 (KRT17) 2. 97 4. 10 431316 AA502663 Hs. 145037 ESTs 296 3. 05 445437 A1224165 Hs. 148725 ESTs 2. 95 7. 12 421690 AW162667 Hs. 106857 calbindin 2, (29kD, calretinin) 2. 95 5. 68 456371 S76825 Hs. 89695 insulin receptor 2. 94 4. 59 449543 AF070632 Hs. 23729 Homo sapiens clone 24405 mRNA sequence 2. 94 4. 12 436664 AW197887 Hs. 253353 ESTs 2. 93 3. 57 406962 M13485 gb : Human metallothionein I-B gene, exon 2. 93 2. 66 422158 L10343 Hs. 112341 protease inhibitor 3, skin-derived (SKAL 2. 92 7. 48 428769 AW207175 Hs. 106771 ESTs 2. 92 3. 28 414629 AA345824 Hs. 76688 carboxylesterase 1 (rtronocytelmacrophage 2. 92 3. 48 444204 A1129194 Hs. 143040 ESTs 2. 92 3. 92 421407 T82331 Hs. 182278 ESTs, Weakly similar to CGHU6C collagen 2. 91 6. 55 453180 N46243 Hs. 110373 ESTs, Highly similar to T42626 secreted 2. 90 3. 92 429538 BE182592 Hs. 139322 small pmline nch protein 2A 2. 88 4. 75 452554 AW452434 Hs. 58006 ESTs, Weakly similar to ALUS HUMAN ALU S 2. 88 6. 74 417184 N52510 Hs. 268597 HomosapienscDNA : FU21498 fis, clone C 2. 87 3. 97 412093 BE242691 Hs. 14947 ESTs 2. 86 3. 48 424135 AW994455 Hs. 140978 HomosapiensmRNA ; cDNADKFZp762H106 (fr 2. 86 3. 32 437167 AL050184 Hs. 21610 DKFZP434B203 protein 2. 86 3. 87 454065 BE394588 gb : 601311808F1 NIH_MGC_44 Homo sapiens c 2. 86 3. 43 420230 AL034344 Hs. 284186 forkheæ box C1 2. 85 3. 67 403108 ENSP00000241415' : Hypothe6cal 67. 7 kDa p 2. 85 2. 62 434433 AW629759 gb : hh70e05. y1 NCI_CGAP GU1 Homosapiens 2. 84 3. 35 420544 AA677577 Hs. 98732 Homo sapiens Chromosome 16 BAC done C) T 2. 83 2. 66 429429 AA829725 Hs. 334437 hypotheticat protein MGC4248 2. 83 3. 59 451721 NM6946 Hs. 26915 spectrin, beta, non-erythrocybc 2 2. 83 3. 36 424982 U94777 phosphorylase, glycogen ; muscle (McArdle 2. 83 4. 50 429259 AA420450 Hs. 292911 Plakophilin 2. 81 4. 81 423523 AW299828 Hs. 193580 ESTs 2. 80 7. 08 433637 AW024214 Hs. 102307 ESTs 2. 80 3. 39 452089 T97294 Hs. 271492 ESTs, Weakly similar to PC4211 hepatocel 2. 80 3. 62 441187 AW195237 Hs. 7734 hypothetical protein FW22174 2. 80 3. 52 421965 AA301100 Hs. 346482 gb : EST14128Tes6stumorHomosapienscD-2. 79 3. 49 432098 AF252297 Hs. 91546 cytochromeP450elinoidmetabolizingpr 2. 79 2. 31 429128 AA446869 Hs. 119316 ESTs 2. 78 4. 17 438913 A1380429 Hs. 172445 ESTs 2. 77 3. 65 445029 AF196481 midline 2 2. 76 3. 79 419923 AW081455 Hs. 120219 ESTs 2. 76 3. 00

416508 R39769 Hs. 56406 ESTs, Moderately similar to ALUB_HUMAN A 2. 76 3. 59 412507 L36645 Hs. 73964 EphA4 2. 76 3. 90 446339 AL046962 Hs. 14845 forehead box 03A 2. 75 3. 50 433710 A1341867 Hs. 188920 ESTs 2. 75 3. 33 432375 BE536069 Hs. 2962 S100 calcium-binding protein P 2. 74 5. 77 409213 U61412 Hs. 51133 PTK6 protein tyrosine kinase 6 2. 74 3. 76 426653 AA530892 Hs. 171695 dual specificity phosphatase 1 2. 74 8. 19 408839 AW277084 gb : xp61h09. x1 NCI CGAP Ov39Homosapiens 2. 73 3. 93 433091 Y12642 Hs. 3185 lymphocyte antigen 6 complex, locus D 2. 73 11. 46 444026 AA205759 Hs. 10119 hypothe6calproteinFLJ14957 2. 73 6. 17 433713 AW976511 Hs. 112592 ESTs 2. 72 3. 42 453317 NM 002277 Hs. 41696 keratin, hair, acidic, 1 2. 72 4. 76 408493 BE206854 Hs. 46039 phosphoglycerate mutase 2 (muscle) 2. 72 3. 74 432947 AA570710 Hs. 270998 ESTs, Weakly similar to 138022 hypotheti 2. 72 3. 44 421428 U26726 Hs. 1376 hydroxysteroid (11-beta) dehydrogenase2 2. 72 4. 95 423217 NM_000094 Hs. 1640 cot (agen, type Vil, alpha I (epidem) olys 2. 72 4. 29 435016 A1284219 Hs. 130749 ESTs, Weakly similar to 138022 hypotheG 2. 71 4. 45 449667 AB023227 Hs. 23860 KIAA1010 protein 2. 71 3. 72 407112 AA070801 Hs. 51615 ESTs, Weakly similar to ALU7 HUMAN AlU S 2. 70 3. 82 433848 AF095719 Hs. 93764 carboxypep6dase A4 2. 70 2. 76 430152 AB001325 Hs. 234642 aquaporin 3 2. 69 4. 26 456063 NM006744 Hs. 76461 retinoi-binding protein 4, inters66al 269 6. 72 424471 AA341329 Hs. 311524 ESTs 2. 68 4. 57 453201 A1432195 Hs. 135098 ESTs 2. 68 3. 69 450912 AW939251 Hs. 25647 v-fosFBJmurineosteosarcomaviraionco 2. 68 4. 25 404996 Target Exon 2. 67 4. 28 409453 A1885516 Hs. 95612 ESTs 2. 65 6. 51 430937 X53463 Hs. 2704 glutathione peroxidase 2 (gastrointesGn 2. 65 3. 78 452887 A1702223 Hs. 107253 hypothe6ca protein DKFZp761F241 2. 64 6. 38 444169 AV648170 Hs. 58756 ESTs 2. 64 3. 40 428500 A1815395 Hs. 184641 fatty acid desaturase 2 2. 64 3. 47 408395 BE072425 Hs. 44579 hypothetical protein FU20199 2. 64 4. 01 432093 H28383 gb : ylS2cO3. r1 Soaresbreat3NbHBstHomo 2. 63 4. 08 451621 A1879148 Hs. 26770 fatty acid binding protein 7, brain 2. 62 2. 51 447335 BE617695 Hs. 286192 hypothefical protein FU20940 2. 61 3. 62 429343 AK000785 Hs. 199480 Homosapiens, Similartoepsin3, clone 2. 61 3. 68 431166 AW971186 Hs. 293839 ESTs 2. 61 3. 33 440659 AF134160 Hs. 7327 claudin 1 2. 61 3. 53 413542 BE295928 Hs. 75424 inhibitor of DNA binding 1, dominant neg 2. 61 4. 48 413956 A1821351 Hs. 193133 ESTs, Weakly similar to ALU7 HUMAN ALU S 2. 60 3. 51 407299 AA460205 Hs. 289770 ESTs, Weakly similar to 138022 hypotheti 2. 59 3. 82 449539 W80363 Hs. 58446 ESTs 2. 58 4. 05 413884 A1668892 Hs. 239758 hypothetical protein FLJ 12389 similar to 2. 58 4. 19 445620 A1245225 Hs. 17441 ESTs 2. 57 3. 44 433688 AA628467 Hs. 112572 Homo sapiens cDNA FLJ14130 fis, clone MA 2. 56 3. 57 424834 AK001432 Hs. 153408 Homo sapiens cDNA FLJ 10570 fis, clone NT 2. 56 3. 47 407083 Z48511 H. sapiens XG mRNA (clone PEP11) 2. 55 3. 61 406790 AA293303 ribosoma protein L27a 2. 54 4. 36 450472 Al190071 Hs. 55278 ESTs 2. 54 4. 30 410310 J02931 Hs. 62192 coagulation factor III (thromboplastin, 2. 54 3. 82 454034 NM_000691 Hs. 575 aldehyde dehydrogenase 3 family, member 2. 54 3. 44 430821 AA487264 Hs. 154974 Homo sapiens mRNA ; cDNA DKFZp667N064 (fr 2. 54 4. 55 402575 Rho GTPase activating protein 1 2. 53 5. 47 429554 NM_012275 Hs. 207224 interteukinl. detta 2. 53 2. 40 431631 AA548906 Hs. 122244 ESTs 2. 52 3. 79 408806 AW847814 Hs. 75608 Homo sapiens cDNA : FLJ21532 fis, clone C 2. 52 4. 51 420235 AA256756 Hs. 31178 ESTs 2. 51 4. 21 436314 A1983409 ESTs 2. 51 3. 11 432906 BE265489 Hs. 3123 lethal giant larvae (Drosophila) homolog 2. 50 5. 62 429547 AW009166 Hs. 99376 FGENESH predicted novel secreted protein 2. 49 2. 60 410532 T53088 Hs. 155376 hemoglobin, beta 2. 49 4. 73 413475 AW021488 Hs. 26981 ESTs 2. 49 3. 90 429325 AW088739 Hs. 243770 ESTs 2. 48 3. 71 424604 AW865388 Hs. 151076 KIAA1243 protein 2. 48 4. 16 414320 U13616 Hs. 75893 ankyrin 3, node of Ranvier (ankyrin G) 2. 48 3. 80 423929 M69136 Hs. 135626 chymase 1, mastcell 2. 48 3. 47 410275 U85658 Hs. 61796 transcription factor AP-2 gamma (activat 2. 47 2. 09 444935 AA262449 Hs. 223569 ESTs 2. 47 5. 96 445389 NM016831 Hs. 12592 period (Drosophila) homolog 3 2. 47 3. 41 437897 AA770561 Hs. 146170 hypothetical protein FLJ22969 2. 47 6. 80 446292 AF081497 Hs. 279682 Rh type C glycoprotein 2. 46 7. 37 409178 BE393948 Hs. 50915 kallikein 5 2. 46 5. 59 452865 A1924046 Hs. 119567 ESTs, WeaklysimilartoA47582B-celigr 2. 46 6. 03 447179 AW015633 Hs. 157299 ESTs 2. 46 3. 23 414459 Y11525 Hs. 76171 CCAAT/enhancer binding protein (C/EBP), 2. 46 3. 95 428188 M98447 Hs. 22 transglutaminase 1 (K polypeptide epider 2. 45 3. 94 428593 AW207440 Hs. 185973 degenerative spermatocyte (homolog Droso 2. 44 2. 17 436009 H57130 Hs. 120925 ESTs 2. 44 2. 94 412810 M21574 Hs. 74615 platelet-derived growth factor receptor, 2. 43 3. 61 416749 AW068550. comp Hs. 79732 fibulin 1 2. 43 4. 46 444672 Z95636 Hs. 11669 laminin, alpha 5 2. 42 6. 39 433143 BE552155 Hs. 294035 ESTs, Weakly similar to ALU5_HUMAN ALU S 2. 42 3. 45 406997 U07807 metallothionein IV 2. 42 3. 92

423184 NM_004428 Hs. 1624 ephrin-A1 2. 41 4. 34 421321 NM 005309 Hs. 103502 glutamic-pyruvate transaminase (alanine 2. 41 5. 08 456826 At871742 Hs. 3U2428 wingiess-type MMN integration site fami 2. 41 3. 92 428897 AJ245719 Hs. 194385 hypothetical protein FLJ20234 2. 41 5. 18 400232 NM001895' : Homo sapiens casein kinase 2. 2. 41 3. 82 421481 AW391972 Hs. 104696 KlM1324protein Z40 4. 03 442083 R50192 Hs. 165062 ESTs 2. 39 4. 21 422287 F16365 Hs. 114346 cytochrome c oxidase subunit Vlla polype 2. 39 8. 60 418004 U37519 Hs. 87539 aldehyde dehydrogenase 3 family, member 2. 39 2. 57 457008 AA410446 Hs. 112011 ESTs, WeaklysimilartounknownlH. sapie 2. 39 3. 85 418355 L42563 Hs. 1165 ATPase. H ? transporting, nongastnc. aip 2. 38 3. 84 431179 A1338644 Hs. 195432 aldehyde dehydrogenase 2family (mitocho 2. 37 7. 89 432563 NM_013261 Hs. 198468 peroxisome proliferative activated recep 2. 37 3. 77 402338 Target Exon 2. 37 3. 46 443725 AW245680 Hs. 9701 growth arrest and DNA-damage-inducible, 2. 37 4. 57 436723 AW975895 Hs. 307486 ESTs 2. 37 6. 39 452669 AA216363 Hs. 262958 hypothetical protein DKFZp434B044 2. 37 3. 92 409212 A1082423 Hs. 141892 ESTs 2. 36 3. 79 451323 A1903313 Hs. 34579 ESTs, Moderately similar to ALU6_HUMAN A 2. 35 3. 29 400307 AF005081 Homo sapiens skin-specific protein (xp32 2. 35 9. 96 421993 R22497 Hs. 110571 growth arrest andDNA-damage-inducible, 2. 35 5. 16 451092 A1207256 Hs. 13766 HomosapiensmRNAforFW00074protein, 2. 34 5. 24 446948 BE409053 Hs. 299629 peroxisomallong-chainacylcoAthioeste 2. 34 3. 77 424425 AB031480 Hs. 146824 SPR1 protein 2. 34 4. 43 426050 AF017307 Hs. 166096 E741ikefætor3 (etsdomaintranscript 2. 34 5. 64 425180 U00115 Hs. 155024 B-cell CLUlymphoma 6 (zinc finger prote 2. 33 3. 51 422106 D84239 Hs. 111732 Fc fragment of IgG binding protein 2. 33 6. 95 423503 M92843 Hs. 343586 zinc finger protein homologous to Zfp-36 2. 33 5. 57 453999 BE328153 Hs. 240087 ESTs 2. 32 3. 40 419358 T78763 Hs. 90063 neurocalcin delta 2. 32 6. 72 430468 NM_W4673 Hs. 241519 angiopoie6n-like 1 2. 32 3. 90 456876 AL044870 Hs. 208780 ESTs, Weakly similar to T29647 hypothefi 2. 32 3. 27 454947 AW846590 gb : OVOCT0180-011099-025-dO7CT0180Homo 2. 32 4. 43 429211 AF052693 Hs. 198249 gap junction protein, beta 5 (connexin 3 2. 31 7. 22 438282 BE268288 Hs. 195432 aldehyde dehydrogenase 2 family (mitocho 2. 31 3. 34 420202 AL036557 Hs. 95910 putative lymphocyte GO/G1 switch gene 2. 31 8. 47 419245 Api732742 Hs. 87440 ESTs 2. 31 3, 39 444920 AW450967 Hs. 235240 ESTs 2. 30 3. 30 417314 N68168 gb : za11cO1. s1Soaresélalliverspleen Z30 3. 12 409586 AL050214 Hs. 55044 DKFZP586H2123 protein 2. 30 3. 52 433662 W07162 Hs. 150826 RAB25 RAB25, member RAS oncogene family 2. 29 6. 11 451176 AA046457 Hs. 60677 ESTs 2. 29 6. 59 410531 AW752953 gb : QVO-CT0224-261099-035gO2CT0224Homo 2. 29 3. 29 425982 R05327 Hs. 189726 ESTs 2. 29 3. 37 435684 NM001290 Hs. 4980 LIM domain binding 2 2. 29 4. 54 453003 AA808466 Hs. 103395 hypothetical protein Fou14146 2. 28 3. 70 434411 AA632649 Hs. 201372 ESTs 2. 28 4. 40 407394 AF005081 gb : Homo sapiens skin-specific protein (x 2. 28 10. 57 411579 AC005258 Hs. 70830 U6 snRNA-associated Sm-like protein LSm7 2. 28 4. 06 401205 Target Exon 2. 27 2. 71 443102 A1247472 Hs. 132965 ESTs 2. 27 5. 66 422109 S73265 Hs. 1473 oastrin-reteasingpeptide 2. 26 3. 94 434987 AW975114 ESTs 2. 26 3. 72 415477 NM002228 Hs. 78465 v-jun avian sarcoma virus 17 oncogene ho 2. 26 3. 42 423515 AA327017 Hs. 176594 ESTs 2. 25 6. 21 434903 AF161369 Hs. 187763 HomosapiensHSPC106mRNA, partialcds 2. 25 3. 62 443049 A1028613 Hs. 132343 ESTs 2. 25 3. 13 444637 T19101 Hs. 11494 fibulin 5 2. 24 6. 43 410026 AI912061 Hs. 55016 hypothetical protein FLJ21935 2. 23 3. 31 418629 BE247550 Hs. 86859 growth factor receptor-bound protein 7 2. 23 4. 17 429587 AA283969 Hs. 334706 Homo sapiens cDNA FU11801 fis, clone HE 2. 23 3. 79 431986 M536130 Hs. 149018 Novel human gene mapping to chomosome 20 2. 22 3. 54 409571 AA504249 Hs. 187585 ESTs 2. 22 3. 87 446051 BE048061 Hs. 37054 ephrin-A3 2. 22 4. 57 422418 AK001383 Hs. 116385 hypothetical protein FLJ 10521 2. 21 4. 25 453023 AW028733 Hs. 31439 senne protease inhibitor, Kunitz type, 2. 21 5. 07 435748 AA699756 Hs. 117335 ESTs 2. 20 3. 35 420105 AW015571 Hs. 32244 ESTs, WeaklysimilartoFMOD HUMANFIBRO 2. 19 6. 55 444922 A) 921750 Hs. 144871 Homo sapiens cDNA FW13752 fis, clone PL 2. 19 3. 51 433052 AW971983 Hs. 293003 ESTs, Weakly similar to PC4259 fernUn 2. 19 3. 32 430310 U60115 Hs. 239069 fourandahalfLIMdomains1 Z19 3. 83 447205 BE617015 Hs. 11006 ESTs, Moderately similar to T17372 plasm 2. 19 15. 65 449967 R40978 Hs. 271498 ESTs, Moderately similar to ALU1 HUMAN A 2. 18 3. 54 452689 F33868 Hs. 284176 transfemn 2. 18 3. 30 417061 A1675944 Hs. 188691 Horno sapiens CDNA FLJ 12033 fis, clone HE 2. 18 3. 77 432647 Al807481 Hs. 278581 fibroblast growth factor receptor 2 (bac 2. 18 5. 64 401192 TargetExon 2. 17 3. 33 421752 AK001521 Hs. 107882 hypothetical protein FU10659 2. 16 3. 44 456646 AJ243662 Hs. 110196 NICE-1 protein 2. 16 2. 39 421263 AB020638 Hs. 103000 KIAA0831 protein 2. 16 3. 37 445656 W22050 Hs. 21299 ESTs, Weakly similar to AF1518401CGI-8 2. 16 5. 17 450624 AL043983 Hs. 125063 Homo sapiens cDNA FU 13825 fis, clone TH 2. 15 3. 87 429350 Api754634 Hs. 131987 ESTs 2. 15 3. 90

448144 AW169230 ESTs, ModeratelysimilartoPC4259teni 2. 14 3. 28 429002 AW248439 Hs. 2340 junction plakoglobin 2. 14 5. 05 429297 X82494 Hs. 198862 fibulin 2 2. 14 4. 32 452093 AA447453 Hs. 27860 HomosapiensmRNA ; cDNADKFZp586M0723 (t 2. 14 3. 99 428848 NM 000230 Hs. 194236 lep6n (murine obesity homolog) 2. 14 3. 39 407584 W25945 Hs. 8173 hypotheticalproteinFLJ10803 2. 14 3. 38 453155 AF052126 Hs. 552 stenoid-Såphareductase, alphapolypep 2. 14 2. 51 453283 AA694386 Hs. 290914 ESTs 2. 13 3. 28 456906 AF117646 Hs. 156637 Cas-Br-M (murine) ectropic retroviral tr 2. 13 3. 76 414815 AW292140 Hs. 130286 ESTs 2. 13 4. 16 417155 T75125 Hs. 299148 hypothetical protein FLJ21801 2. 13 3. 57 416673 T77052 Hs. 14039 ESTs 2. 13 3. 43 452208 AA024792 Hs. 31895 hypothetica) protein MGC4093 2. 12 5. 67 413966 AA133935 Hs. 173704 ESTs, Moderately similar to A53959 throm 2. 12 4. 76 430967 H16791 Hs. 100895 ESTs 2. 12 2. 64 429015 BE168484 Hs. 194737 KIAA0453protein Z12 3. 30 439518 W76326 gb : zd60d04. r1Soaresfeta) heartNbHH19W 2. 11 2. 59 426468 AA379306 Hs. 117558 ESTs 2. 10 3. 56 407555 Z48511 gb : H. sapiensXGmRNA (clonePEP11). Z10 3. 66 418226 AA424202 Hs. 83834 cytochrome b-5 2. 10 5. 14 423441 R68649 Hs. 278359 absent in melanoma 1 like 2. 10 3. 64 436961 AW375974 Hs. 156704 ESTs 2. 10 3. 21 432633 Api796390 Hs. 210667 ESTs 2. 10 2. 58 426102 AF200496 Hs. 166371 interleukin 1, zeta 2. 09 3. 77 445467 Api239832 Hs. 15617 ESTs, Weakly similar to ALU4_HUMAN ALU S 2. 09 3. 85 437124 AA554458 KiAA0666protein 2. 09 3. 35 407757 BE048414 Hs. 165215 hypothetical protein MGC5395 2. 08 4. 41 407815 AW373860 Hs. 183860 hypothefical protein FU20277 2. 08 5. 01 443906 AA348031 Hs. 7913 ESTs 2. 08 3. 40 423887 AL080207 Hs. 134585 DKFZP434G232 protein 2. 08 3. 92 406400 kallikrein 8 (neuropsinlovasin) (KLKB) 2. 08 4. 19 437704 AA766142 Hs. 131810 ESTs, Moderately similar to ALU1 HUMAN A 2. 07 3. 30 412533 AA679863 Hs. 69606 ESTs 2. 07 3. 39 426310 Nom-000909 Hs. 169266 neuropeptideY receptor Y1 2. 06 3. 55 411821 BE299339 Hs. 72249 three-PDZ containing protein similar to 2. 06 4. 98 442599 AF078037 Hs. 324051 ReIA-associated inhibitor 2. 06 7. 23 432212 AW137742 ESTs 2. 04 3. 52 453469 AB014533 Hs. 33010 KIAA0633 protein 2. 04 4. 01 443652 Al080692 Hs. 134229 ESTs, Weakly similar to 154401 hypertens 2. 04 3. 36 452955 AW390282 Hs. 31130 transmembrane 7 superfamily member 2 2. 03 3. 64 424464 R68537 Hs. 17962 ESTs 2. 03 4. 36 408702 AW959893 Hs. 27099 hypothetical protein FLJ23293 similar to 2. 03 3. 31 439908 A1168031 Hs. 155507 ESTs 2. 03 3. 83 412825 AW167439 Hs. 190651 Homo sapiens cDNA FLJ 13625 fis, clone PL 2. 02 5. 56 406784 Al144297 Hs. 169401 apolipoprolein E 2. 02 3. 40 427309 NM 005714 Hs. 175218 potassium channel, subfamily K, member 7 2. 02 4. 58 453195 BE241876 Hs. 32352 hypothetical protein DKFZp434K1210 2. 02 3. 57 404246 Target Exon 2. 01 7. 30 443679 AKW1810 Hs. 9670 hypothetical protein FLJ10948 2. 01 5. 81 410669 AW805749 superoxide dismutase 2, mitochondriai 2. 01 3. 05 446193 Api279390 Hs. 144658 ESTs, Weakly similar to T17257 hypotheti 2. 01 2. 32 449228 AJ403107 Hs. 148590 protein related with psoriasis 2. 00 5. 10 434346 AA630445 ESTs 2. 00 3. 51 456098 AW747800 Hs. 55016 hypothetical protein FLJ21935 2. 00 4. 96 452467 AW500815 ESTs 2. 00 4. 66 442866 A1743317 Hs. 283622 ESTs, WeaklysimilatoALU5 HUMANALUS 1. 98 3. 72 434699 AA643687 Hs. 149425 Homo sapiens CDNA FU 11980 fis. clone HE 1. 98 3. 11 417553 L09190 trichohyalin 1. 98 2. 09 449142 R15913 Hs. 194987 ESTs 1. 98 3. 50 407597 AA043925 Hs. 339352 Homo sapiens brother of CDO (BOC) mRNA, 1. 98 6. 25 429299 A1620463 Hs. 347408 hypothetical protein MGC13102 1. 97 3. 77 423031 A1278995 ESTs 1. 97 3. 62 433495 AW373784 Hs. 71 alpha-2-glycoprotein 1, zinc 1. 96 4. 57 430420 AW140027 Hs. 26373 Homo sapiens cDNA : FLJ23449 fis, clone H 1. 96 6. 09 420139 NM 005357 Hs. 95351 lipase, hormone-sensitive 1. 95 5. 77 418462 BE001596 Hs. 85266 integnn, beta4 1. 95 6. 09 447261 NM006691 Hs. 17917 extracellular link domain-containing 1 1. 95 3. 33 437220 AL117542 Hs. 334305 GS1999full 1. 94 3. 45 407601 AC002300 Hs. 37129 sodium channel, nonvoltage-gated 1, beta 1. 94 5. 46 443595 AF169312 Hs. 9613 PPAR (gamma) angiopoietin related protein 1. 94 4. 67 409007 AL122107 Hs. 49599 HomosapiensmRNA ; cDNADKFZp434G0827 (f 1. 94 3. 59 408717 AF045458 Hs. 47061 unc-51 (C. efegans) 4ike kinase 1 1. 94 4. 29 420055 NM001487 Hs. 94672 GCN5 (general control of amino-acid synt 1. 94 3. 38 430392 NM000627 Hs. 241257 latent transforming growth factor beta b 1. 93 3. 75 425078 NM 002599 Hs. 154437 phosphodieslerase2A, cGMP-slimulaled 1. 93 4. 06 423527 AI206965 Hs. 105861 hypothetical protein FU13824 1. 93 4. 70 447151 A1022813 Hs. 92679 Homo sapiens clone CDABPOOL 4 MRNA sequen 1. 91 3. 77 422101 AW404176 Hs. 111611 ribosomal protein L27 1. 91 3. 18 456653 A1807519 Hs. 104520 Homo sapiens cDNA FLJ13694 fis, clone PL'9'3 4' 443444 AW952619 Hs. 17235 HomosapienscloneTCCCIA00176mRNAsequ 1. 91 3. 52 420924 R01026 Hs. 245321 ESTs 1. 91 3. 22 426048 A1768853 Hs. 134478 ESTs 1. 90 3. 56 414092 Z14244 Hs. 75752 cytochromecoxidaesubunitVllb 1. 90 4. 15

415274 AF001548 Hs. 78344 my0. sin, heavy polypeptide 11, smooth mus 1. 90 5. 88 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin 1. 90 2. 28 418418 R61527 Hs. 237517 ESTs 1. 90 3. 56 449372 AA001266 Hs. 133521 ESTs 1. 89 3. 90 438752 AW238673 Hs. 146038 ESTs 1. 89 5. 24 428193 NM_004235 Kruppel-likeTætor4 (gut) 1. 89 5. 21 433251 AB040955 Hs. 322735 KIM1522 protein 1. 89 5. 00 430560 Z28942 Hs. 243960 N-myc downstream-regulated gene 2 1. 89 7. 09 427795 BE268268 Hs. 180842 hbosomai protein L13 1. 89 4. 51 410209 Ai583661 Hs. 60548 hypothetical protein PR01635 1. 89 3. 35 449243 AW295031 Hs. 198671 ESTs 1. 89 4. 26 420225 AW243046 Hs. 282076 Homo sapiens MRNA for KIAAL 650 protein, 1. 88 6. 20 443932 AW888222 Hs. 9973 tensin 1. 88 9. 28 427929 BE613835 Hs. 181159 HomosapiensmRNA ; cDNADKFZp434F0217 (f 1. 87 4. 25 400078 Eos Control 1. 87 6. 73 422639 A1929377 Hs. 173724 creatine kinase, brain 1. 87 5. 51 447374 AF263462 Hs. 18376 KIAA1319 protein 1. 87 3. 42 430346 AK000331 Hs. 297641 KIAA0462 protein 1. 87 4. 15 428223 AA424313 Hs. 98402 ESTs 1. 87 3. 70 408792 L29433 Hs. 47913 coagulation factor X 1. 87 4. 08 433855 AA834082 Hs. 307559 ESTs 1. 87 4. 16 451583 A1653797 Hs. 24133 ESTs 1. 87 3. 81 426377 AK001921 Hs. 169575 hypothetical protein MGC2550 1. 86 5. 55 431647 AL138578 Hs. 266738 hypothe6calprotein dJ796117. 1 1. 86 3. 74 422055 NM 014320 Hs. 111029 putative heme-binding protein 1. 86 4. 68 425750 AL050276 Hs. 42400 zinc finger protein 288 1. 86 4. 04 422491 AA338548 Hs. 117546 neuronatin 1. 86 4. 37 438942 AW875398 Hs. 6451 PR00659 protein 1. 85 5. 06 400198 Eos Control 1. 85 5. 22 427136 AL117415 Hs. 173716 adisintegrinandmetalloproteinasedoma 1. 85 3. 41 427605 Nom-000997 Hs. 337445 ribosome protein L37 1. 85 4. 73 418253 AA215539 Hs. 283643 HomosapienscDNAFW11606fis, cloneHE 1. 84 5. 94 441912 AA971484 Hs. 159938 ESTs 1. 84 3. 73 421632 AA825426 Hs. 334689 ESTs, Weakly similar to ALU1 HUMAN ALU S 1. 83 3. 62 440602 A1743491 Hs. 292692 ESTs 1. 83 2. 39 431882 NM 001426 Hs. 271977 engrailed homolog 1 1. 83 3. 30 420772 AW752656 Hs. 222707 KIAA1718 protein 1. 83 3. 73 429197 H24471 Hs. 26930 ESTs, Weakly similar to T20272 hypotheti 1. 82 3. 41 450796 NM 001988 Hs. 25482 envoplakin 1. 82 7. 73 426928 AF037062 Hs. 172914 etinol dehydrogenase 5 (11-cis and 9-ci 1. 82 3. 38 415409 AW993701 NS1-associated protein 1 1. 82 3. 60 401131 NM001651' : Homosapiensaquaponn5 (AQP 1. 82 5. 53 421324 BE257515 Hs. 103503 deoxyribonuclease I-like 2 1. 81 5. 53 400079 Eos Control 1. 81 6. 79 430513 AJ012008 Hs. 241586 G6Cprotein 1. 81 7. 49 426508 W23184 Hs. 170171 glutamate-ammonia ligase (glutamine synt 1. 81 3. 55 425883 AL137708 Hs. 161031 Homo sapiens mRNA ; cDNADKFZp434K0322 (f 1. 80 5. 43 429191 AF065215 Hs. 198161 phospholipase A2, group IVB (cytosolic) 1. 79 5. 90 432417 AL040360 Hs. 162203 ESTs, Weakly simitar to aitemativeiysp 1. 79 3. 63 406467 Target Exon 1. 79 4. 16 444135 AK000374 Hs. 10346 hypotheticaproteinFW20t54,'. 79 3. 32 426402 BE387327 Hs. 80475 polymerase (RNA) II (DNA directed) polyp 1. 78 3. 51 412524 AA417813 Hs. 44208 hypothetical protein FLJ23153 1. 78 3. 72 425880 X01630 Hs. 160786 argininosuccinate synthetase 1. 78 3. 29 400300 X03363 HER2 receptor tyrosine kinase (c-erb-b2, 1. 78 3. 44 451304 M92642 Hs. 26208 collæen, type XVI, åpha 1 1. 78 3. 57 400082 Eos Control 1. 78 3. 82 446603 NM 014835 Hs. 15519 oxysterol-binding protein-related protei 1. 77 3. 48 425415 M13903 Hs. 157091 invotucrin 1. 77 4. 64 400083 Eos Control 1. 77 6. 31 427620 Nu003705 Hs. 179866 solute carrier family 25 (mitochonddal 1. 76 3. 47 446971 Api652143 Hs. 288382 hypothetical protein FU13111 1. 76 4. 21 429807 AK002138 Hs. 306227 Homo sapiens CDNA FU 11276 fis, clone PL 1. 76 2. 63 446560 AK001567 Hs. 311002 Homo sapiens cDNA F1J10705 fis, clone NT 1. 76 3. 82 412824 AW958075 Hs. 11261 smali proline-rich protein 2A 1. 76 4. 31 439927 AA854650 Hs. 124597 ESTs 1. 75 3. 63 410223 S73775 Hs. 60708 calsequestrin 1 (tat-twitch, skeletå m 1. 75 3. 79 414500 W24087 Hs. 76285 DKFZP564B167 protein 1. 75 3. 55 448182 AF244137 Hs. 20597 hostcellfactorhomolog 175 340 439651 AF086480 Hs. 56255 ESTs 1. 75 2. 55 430486 BE062109 Hs. 241551 chloride channel, calcium activated, fam 1. 75 3. 54 424389 AA339786 lymphocyte-specific protein 1 1. 75 4. 48 450837 D58463 Hs. 85969 hypotheticalprotein FU12270 1. 74 3. 40 425920 AL049977 Hs. 162209 claudin 8 1. 74 3. 33 435680 H50946 Hs. 284183 Homo sapiens galectin-related inhibitor 1. 74 3. 47 439639 AA370045 Hs. 6607 AXIN1 up-regulated'-73 5. 22 416950 AL049798 Hs. 80552 dermatopontin 1. 73 4. 99 400199 E Control 173 6. 25 409737 AB011539 Hs. 56186 EGF-iike-domain, multiple 3 1. 73 4. 28 424420 BE614743 Hs. 146688 prostagiandin E synthase 1. 72 3. 42 421545 AA292810 Hs. 90034 hypothetical protein FLJ21916 1. 72 2. 12 414323 NM 014759 Hs. 334688 KIAA0273 gene product'7'4. 82 407228 M25079 Hs. 155376 hemoglobin, beta 1. 70 7. 02

406643 N77976 Hs. 347939 hemoglobin, alpha 2 1. 70 3. 60 447299 AF043897 Hs. 18075 chromosome 9 open reading frame 3 1. 70 5. 10 439733 AL365412 Hs. 107203 hypothetical protein from EUROIMAGE 1759 1. 69 2. 92 415512 Y16270 Hs. 78482 paralemmin 1. 69 4. 92 407100 R29657 gb : F1-1179D 22 week old human fetal live 1. 69 3. 96 425503 W92517 Hs. 158203 actin binding LIM protein 1 1. 68 5. 97 433738 A1684802 ESTs 1. 68 2. 88 406791 Api220684 Hs. 347939 hemoglobin, alpha 2 1. 68 3. 44 428975 NM 004672 Hs. 194694 mitogen-activated protein kinasekinase 1. 68 2. 74 435661 AF220263 Hs. 193920 MOST2 protein 1. 67 3. 56 459317 BRCAtb b Eos Control 1. 67 3. 34 426923 AF112977 Hs. 172887 phytanoyl-CoA hydroxylase (Refsum diseas 1. 67 4. 53 426682 AV660038 Hs. 2056 UDP glycosyltransferase 1 tamily, polype 1. 67 3. 36 417029 AW952192 Hs. 273385 guanine nucleotide binding protein (G pr 1. 67 5. 22 437201 F29279 Hs. 171625 hypothetical protein MGC14697 1. 67 5. 75 454478 AW805749 superoxide dismutae 2, mitochondrial 1. 67 4. 55 406710 Api708347 Hs. 184014 dbosomal protein L31 1. 66 3. 80 431593 NM_002108 Hs. 276590 ESTs 1. 66 2. 45 457820 AA341497 Hs. 31408 RAR (RAS like GTPASE) 1. 66 2. 44 441899 A1372588 Hs. 8022 TU3A protein 1. 66 4. 06 414186 U33446 Hs. 75799 protease, serine, 8 (prostasin) 1. 65 6. 52 418116 AA252457 Hs. 86543 ESTs, Moderately similar to T00256 hypot 1. 65 3. 44 403105 Target Exon 1. 64 4. 12 450014 N41322 Hs. 18441 ESTs 1. 64 2. 90 436685 W28661 Hs. 5288 Homo sapiens mRNA ; cDNA DKFZp434M245 (fr 1. 64 4. 49 401429 C14001067 : gij41264651dbjíBM36581. 1l (AB 1. 64 3. 82 420983 W95228 Hs. 100764 cathepsin G 1. 64 3. 64 433126 AB021262 Hs. 99816 beta-catenin-interac6ng prolein ICAT 1. 63 3. 29 428150 AW950547 Hs. 70312 cytochrome c oxidase subunit Vlla polype 1. 63 7. 05 412295 AW088826 poly (A)-binding protein, nuclear 1 1. 63 4. 01 430831 AA703239 Hs. 269804 ESTs, Weakly similar to ALUI-HUMAN ALU S 1. 63 3. 60 429348 AJ242859 Hs. 199731 Langerhans cell specific c-type lectin 1. 62 2. 64 407082 247055 gb : Human partial CDNA sequence, famesyl 1. 62 2. 13 452556 H78517 Hs. 33905 ESTs 1. 62 4. 64 415688 AA166963 gb : zo86dO1. sl Stratagene ovarian cancer 1. 62 3. 33 446515 AL048875 hypothetical protein DKFZp5661133 1. 62 3. 66 445919 T53519 Hs. 334692 hypothetical protein MGC14141 1. 62 5. 65 447330 BE279949 Hs. 18141 ladinin 1 1. 61 5. 61 412374 X01388 Hs. 73849 apolipoprotein C411 1. 61 5. 18 400229 NM 021724' : Homo sapiens nuclear receptor 1. 61 3. 57 414814 D14697 Hs. 77393 famesyl diphosphate synthase (farnesyl 1. 61 2. 08 424397 Al950320 gb : wpO8d10. x1 NCl_CGAP_Kid12Homosapien 1. 60 3. 59 451335 AB023192 Hs. 26285 imidazoline receptor candidate 1. 60 5. 54 426156 BE244537 Hs. 167382 natriueticpepUdeeceptorA/guanylate 1. 60 4. 79 456267 A1127958 Hs. 83393 cystatin E/M 1. 60 2. 50 436950 L05779 Hs. 113 epoxidehydrolae2, cytoplamic 1. 60 3. 98 421397 S67368 Hs. 103998 gamma-aminobutyric acid (GABA) A recepto 1. 60 3. 28 419092 J05581 Hs. 89603 mucin 1, transmembrane 1. 60 3. 69 440160 BE560269 Hs. 7010 NPD002 protein 1. 59 2. 49 417481 AA203281 Hs. 6191 ESTs 1. 59 3. 60 406778 H06273 Hs. 101651 Homo sapiens mRNA ; cDNA DKFZp434C107 (fr 1. 58 3. 98 402991 Target Exon 1. 58 3. 36 425169 AW292500 Hs. 128514 ESTs 1. 58 4. 00 446429 A1681807 Hs. 201391 ESTs 1. 58 3. 20 426445 AA378739 Hs. 187711 ESTs 1. 57 3. 63 425196 AL037915 Hs. 155097 carbonic anhydrase 11 1. 57 3. 44 422581 NM016339 Hs. 118562 Link guanine nucleotide exchange factor 1. 57 3. 55 440054 AW661947 Hs. 6891 splicing factor, arginine/sedne-dch 6 1. 56 3. 39 415988 BE407713 Hs. 78943 bleomycin hydrolase 1. 56 2. 43 441860 AW451330 Hs. 348198 hypothetical protein FU20262 1. 55 3. 38 428462 At571486 Hs. 30258 ESTs 1. 55 3. 65 449518 BE395253 Hs. 30861 ESTs 1. 55 3. 80 420075 AF142482 Hs. 203846 TEA domain family member 3 1. 55 3. 81 406799 AA908548 gb : og83g12. s1 NCI_CGAP_Ov8 Homo sapiens 1. 54 3. 87 450787 AB006190 Hs. 25475 aquaporin 7 1. 54 4. 06 419659 AB023206 Hs. 92186 Leman coiled-coil protein 1. 54 3. 82 408543 N78098 Hs. 44289 ESTs 1. 54 3. 10 410169 Api373741 Hs. 59384 hypothetical protein MGC3047 1. 54 4. 73 426068 AF029778 Hs. 166154 jagged 2 1. 54 4. 82 432191 AA043193 Hs. 273186 hypotheticåprotein, cloneTelethon (lta 1. 54 5. 83 415166 NM003652 Hs. 78068 carboxypeptidae Z 1. 54 4. 58 410048 W76467 Hs. 343874 protine oxidase homolog 1. 54 4. 66 430502 Al123657 Hs. 127264 ESTs, Weakly similar to JC5314 CDC28/cdc 1. 53 3. 41 433640 AW390125 Hs. 240443 Homo sapiens cDNA : FLJ23538 fis, clone L 1. 53 4. 57 413353 AW293542 Hs. 75309 eukaryotic translation elongation factor 1. 53 3. 59 431021 A1869664 thiosulfate sulfurtransferase (rhodanese 1. 53 3. 73 431243 U46455 Hs. 252189 syndecan4 (amphiglycan, ryudocan) 1. 52 6. 09 433019 A) 208513 Hs. 279915 transtocaseofinnermitochondnatmembr 1. 52 4. 49 406801 AW242054 Hs. 190813 ribosomal protein L9 1. 51 5. 56 427461 AA531527 Hs. 332040 hypothetical protein MGC13010 1. 51 3. 77 432894 AW167668 Hs. 279772 brain specific protein 1. 51 6. 72 415550 L13720 Hs. 78501 growth arrest-specific 6 1. 50 4. 02 424707 BE061914 Hs. 10844 Homo sapiens cDNA FLJ 14476 fis, clone MA 1. 49 4. 21

445624 AW140103 Hs. 78880 iivB (bacterial acetolactate synthase)-I 1. 48 3. 61 445071 A1280246 Hs. 149504 ESTs 1. 48 3. 39 440763 AB028988 Hs. 7407 KIAA1065 protein 1. 48 4. 03 451988 AF263928 Hs. 27410 papillomavirus regulatory factor PRF-1 1. 47 3. 58 427841 AW883367 hypothetical protein MGC5306 1. 47 3. 61 426335 A1054347 Hs. 2017 ribosome protein L38 1. 47 3. 76 454098 W27953 Hs. 292911 Plakophilin 1. 46 2. 95 456766 R87310 Hs. 7740 oxysterol binding protein-like 1 1. 46 3. 40 440526 Al832243 ESTs 1. 46 3. 38 452586 AW958479 Hs. 289043 spindlin 1. 45 3. 48 433399 N46406 Hs. 84700 similar to phosphatidylcholine transfer 1. 45 3. 44 430238 N72519 Hs. 236545 hydroxyacid oxidase 2 (long chain) 1. 45 4. 00 425456 T70445 Hs. 157850 ribosoma) protein L9 1. 45 4. 79 411085 AF022991 Hs. 68398 period (Drosophila) homolog 1 1. 45 4. 43 433638 AW872507 Hs. 3462 cytochrome c oxidase subunit Vllc 1. 44 3. 89 445156 N89367 Hs. 12373 adenylate cyclase 6 1. 44 3. 60 446576 A1659477 dystroglycan 1 (dystrophia-associated gl 1. 44 3. 07 440433 AA252452 Hs. 7187 hypothetical protein FLJ10707 1. 43 3. 67 434536 H14486 Hs. 3903 Cdc42 effector protein 4 ; binder of Rho 1. 42 3. 35 423513 AF035960 Hs. 129719 hwsglutaminase 5 1. 42 3. 18 418681 AA287786 Hs. 23449 insulin receptor tyrosinekinasesubstra 1. 42 3. 38 421935 AA131632 Hs. 109672 CMP-NeuAC : (beta)-N-acetylgalactosaminide 1. 41 4. 04 406712 M31212 Hs. 77385 myosin, light polypeptide 6, alkali, smo 1. 41 4. 27 413944 AW001579 Hs. 9645 Homo sapiens mRNA for KIAA1741 protein, 1. 41 3. 80 435879 AW084463 Hs. 30002 SH3-containing protein SH3GLB2, KIM1843 1. 41 3. 55 417967 BE244373 Hs. 1119 nuclear receptor subfamily 4, group A, m 1. 40 4. 07 412669 AW880841 Hs. 96908 p53-induced protein 1. 40 3. 59 415523 AL042003 Hs. 296847 cell matrix adhesion regulator 1. 40 4. 38 406713 U02629 Hs. 77385 myosin, lightpolypep6de6, alkaii, smo 1. 39 4. 03 439606 W79123 Hs. 58561 G protein-coupled receptor 87 1. 39 3. 65 430135 NM 000035 Hs. 234234 aldolase B, fructose-bisphosphate 1. 37 3. 99 422682 W05238 Hs. 94316 ESTs, WeaklysimilatoT31613hypothe6 1. 36 3. 30 408198 AA131111 gb : zo16bO6. r1Stratagenecolon (937204) 1. 36 3. 33 419600 AA448958 Hs. 91481 NEU1 protein 1. 35 3. 49 437141 BE304917 Hs. 31097 hypothetical protein FU21478 1. 34 3. 47 408250 R92918 Hs. 19597 KIM1694 protein 1. 34 3. 89 430012 NM 015373 Hs. 227637 chromosome 22 open reading frame 2 1. 32 4. 24 425183 W76098 Hs. 19223 HCCA2protein 1. 32 3. 52 427706 AW971225 Hs. 293800 ESTs, Weakly similar to ALU1 HUMAN ALU S 1. 32 3. 50 438303 A8028998 Hs. 6147 MAA1075 protein 1. 32 3. 71 406800 AA505535 gb : nh84h10. s1 NCl_CGAP_Br1. 1 Homosapien 1. 32 3. 65 442533 AA161224 Hs. 8372 ubiquinol-cytochrome c reductase (6. 4kD) 1. 32 4. 14 428475 AF172940 Hs. 184542 CGI-127 protein 1. 31 3. 43 406742 AI468091 Hs. 279860 tumor protein, translationafly-controlle 1. 30 3. 34 432295 BE091049 Hs. 343665 ribosome protein S15a 1. 30 3. 29 422959 AV647015 paired immunoglobulin-like receptor beta 1. 28 3. 53 402956 ENSP00000244002' : KIAA1335 protein (Fragm 1. 24 3. 38 406743 AA911568 Hs. 279860 tumor protein, translationaAy-controlle 1. 24 3. 70 437142 AI791617 Hs. 145068 ESTs, Moderately similar to A46010 X-lin 1. 23 3. 48 424372 AW952803 Hs. 21732 HomosapienscDNAFtJ11780fis, doneHE 1. 18 2. 44 414716 AF199598 Hs. 97044 Kv channel-interacting protein 2 1. 18 3. 43 431931 AB035302 Hs. 272212 cadherin 9, bpe 2 (T1-cædherin) 1. 15 2. 49 406587 C15000544* : gil54541481reqNP-006368. 11 U 1. 06 2. 25 409574 AW419080 Hs. 250645 ESTs 1. 00 3. 60 417435 NM_005181 Hs. 82129 carbonicanhydraselll, musclespecrfic 1. 00 3. 44 402075 ENSP00000251056' : Plasma membrane calcium 1. 00 3. 37 422330 D30783 Hs. 115263 epiregulin 1. 00 3. 35 418986 A1123555 Hs. 81796 ESTs 1. 00 3. 28 404175 Target Exon 1. 00 3. 08 452640 AA027115 Hs. 100206 ESTs, Weakly similar to A53856 aryl-acyl 1. 00 2. 82 443564 AI921685 Hs. 199713 ESTs 1. 00 2. 51 TABLE 64B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 412636 1438_1 M77830 NM_044415 AF139065 BG681115 BG740377 81712964 BG000656 AA128470 81438324 H27408 BE931630 BE167165 AW370827 AW370813 J05211 BG698865 BG740734 BG680618 BG739778 B1765807 BM353403 BM353248 AW177784 AW205789 AW951576AW848592 BE182164 8F149266 SE940187 81060445 81060444 BF350983 BE720095 BE720069 BE715154 BE082584 BE082576 BE004047 AA857316 81039774 BE713818 BE713548 AW170253 BE160433 B1039775 AW886475 BM462504 BE931734 BF149264 AA340777 BF381183 BG621737 AU127260 AW364859 BF993352 BG223489 8E819009 BF381184 BE7i5956 R58704 AA8522t2 AW366566 BI090358 BF087707 8E819046 BE819005 M377127 BE073467 BE819069 BE819048 81036306 8G990973 81040954 8F919911 AU140155 A1951766 A1434518 AW804674 8F752969 8E837009 8E925826 BF149265 AW995615 BE814264 B1039782 AU140407 BE144243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF086994 BF592276 BE082507 BE082514 BE082505 BF873693 AW068840 AW847678 BF804153 AW365157 BE813930 BE002030 AW365153 BE184941 BF749421 BE184920 BF839562 BE184933 BF842254 BE698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 W39488 C04715 BF096124 BE865341 AW799304 AL603116 BE149760 BE705967 BE705966 BE705968 AW848723AW376699 AW376817 AW376697 8GO05097 BF751115 BE696084 AW848371 AW376782 AW848789 AW849074 AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 BG005197 BF350086 8E715196 8E715155 BF752396 BF093817 BF831190 BF752409 BE006561 BG959922 BF094833 BF094748 8F094583 AW377699 AW607238 BE082519 AW377700 BF349467 A1190590 Al554403 Al392926 AU158477 Bl467252 AU159919 A1760816 BF082516 Al439101 M451923 A1340326 A1590975 B1791553 Al700953

Al142882 AA039975 AA946936 AA644381 BM314884 AA702424 AI417612 AW 190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW166807 AI346078 W95070 AA149191 AA026864 AI830049 AW780435 A1078449 AI819984 AI858282 81468588 AI860584 A1025932 AA026047 AA703232 AA658154 AA515500 AW192085 AA918281 T77861 AI927207 AI205263 BF082491 AW021347 AI568096 BE939862 AA088866 D12062 M056527 M782109 W19287 W02156 AW150038 M022701 T87181 H44405AN10434 BF082513 AM94069 A) 270027 A ! 635878 AA128330 BG681425 BE706078 R20904 BG680059 BG676647 BF764409 AA026654 AV745530 81762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 Al571075 8E067786AV721320AI022862 N29754 C03378 N84767 AA131077 H30146 BE714290 Al686869 Al568892 Al915596 AW105614 AI887258 AI538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 Al905927 BF992780AW853812 BG954443 B1770953 BG679406 BG740832 BG681087 BG698430 AA455100 T87267 BE696209 BE696210 Bl089483 BEW6273 BE872225AW391912 BE925515 BG677012 BG741970 AA026480 BE705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 Bl040941 M337270 AW384371 AW847442 But058659 BE813665W95048 W25458 AW177786 AA025851 BE931733 BF154837 BG949393 BE714441 AW996245 BE711801 A12B4090 SE064323 BE719390 BE940148 BG991212 BF375714 BF349522 BG996267 T48793 Bl013292 BE001925 AW365156AW365154AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W38382 A1498487 407328 534268 1 A1673735 AA978066 427890 13739881 AA417099 AA435761 AA972917 A ! 660387 440116 4546731 R69942 BG655457 BF111453 AI149320 N23160 AI446431 AI758316 AV741781 81791950 BM055014 AI798851 AA865357 AI417230 N67277 T55592 T52179 444105 6497881 AW189097AI123917AI723926 431926 1237041 1 AW972724 AA877998 AA522631 AU185388 424399 2196 1 NM 058173 AF414087 W72837 BF742809 AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 AI139456 BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 AI127172 BE815819 Al905624 R75793 BG202313 A1905837 BE815853 426101 3211 1 AL049987 BG620667 BG571984 AW362842 BE150456 BE326465 AW872412 AA868553 A1024689 AA442638 AA813604 AA442648 AA663108 AA442379 AA229448 N56349 AA460220 AW971193 AA453725 Al742087 Al860142 AW769479 Al917507 Al860141 BE045272 AW277065 Al921333 Api354470 BE466760 AI827987 A1005467 AA833517 AA563934 AA522837 AA812876 AW020895 AA600372 AA663178 Al187977 AA229164 AW270324 AA703066 T78981 AA632986 BE708493 R31132 Au53986 Api916737 T84796 T84294 AW961515 A1459289 BF109829 B1491853 A1084517 AW103830 BE835233A1472712AV741009M551512 N28268 AA436880 AA447794 BE835410 BE835385 BE818352 BE818350 R64648 BE646467 AA493776 AA437299 BE818343 R95914 R31089 BF576826 AU186065 BF802058 AI217018 AA247541 AN91725 BE766918 438962 195763 1 AI207343 BF813684 BF928775 AA828585 445493 423456 1 AV711317 AI809938 AI808768 AI240593 AI915771 407102 7177_2 AW945170 BF930905 F33652 BG057818 Al368018 Al421485 Al300352 Al378525 Al264177 Al276281 Al245302 Al281050 Al190036 AW451438 AW242903 AA910870 F22289 F19647 F22375 AW473816 BF445785 AA774528 F33447 C01077 AW772227 F17759 H42812 R09701 AA349096 R48772 H42892 H42537 R47898 N28263 H25721 F32386 H43971 R48205 F21390 H45809 AA007629 R47897 R83734 H45844 AW983653 H43970 H42536 H24495 R48875 H42961 H22079 R86018 421998 133592_1 Bl757233 BG911321 BF351759 AW244016 AW026834 AW024260 A1420138 AA779354 A1093360 A1934858 AW151292 A1373133 A1335587 A1969728 AA101632 BE218525 AI802114 AI783721 AA845265 AW088826 AI832852 F03967 AI611148 AI720358 AW293764 N91161 R79192 W85852 AW771263 BG820263 BG012864 R74441 R86080 W04256 BE707244 BF899452 BE327552 BE669500 AI492388 AI241532 BF448184 Al209012 AA886528 N70309 AW582776 BF110563 BF448329 BE326537 AW770471 BF444926 BE674147 Al793266 AI991774 AI807726 AI218667 AA301750 R44328 408239 103120 1 AW469418 AA053401 AA053416 437611 240436 1 H93046 AA897108 Al652046 M761626 BF882276 N68615 T88896 H93912 T84424 456332 21353 10 BG740624 AV720262 BG198346 BG215119 AW841716 AA228357 AW841786 458222 6313321 AA932742AW593558AW139592 434206 185910 1 BF591031 AW205438 AA933791 AI434866 BF513564 AI191480 AI972330 AI582824 AW779392 AI359970 AI199117 AI910783 BF800971 AA627401 AI799778 BF222639 AI937737 AW136973 400295 21961 NM058173 AF414087 W72837 8F742809 AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 Api139456 BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 Al127172 BE815819 Api905624 R75793 BG202313 A1905837 BE815853 417054 124052 BG533564 BG618564 AW296119 Api269233 BF508328 AW364777 AW292258M371049 Al452471 Al092522 BG618376 AL049080 AA631068 BG564643 T53833 AV702544 BG533452 AV705004 AA588281 T28665 BG569026 AV646874 AV647253 AV647455 AV647749 B1759444 AV652457 AV695354 AV696010AV697248 BG617586 AV722549 AI435836 AI590676 AI245019 AW338243 AA530898 D52191 Api435352 D57473 BG566952 A1420505 AA035245 AV704972 BG564113 Al439237 Al287456 AV695636 M349017 423974 888155 1 AL118754 AA333202 H38001 412668 332301 AK057749 AI701055 AA115476 AI633570 AI435607 AW173392 A1092468 AI989318 AA833891 AW295964 AI804107 AI767415 AI473818 A1076758 AA278949 AA428547 N31385 H82560 AA464804 AA809073 AA832476 AW295298 BF108690 Api492243 N22394 AA487175 AA431891 AW070941 AA278823 AA707840 AI346067 AI184307 AA936342 AI288633 AA425697 AI435960 AI301433 AA993394 AI917652 AA487234 AA490964 AA937925 Al301378 A1783840 A1093652 AA723864 BF001378 81818971 B1762256 AW957064 BG720359 Bl821176 Bl906440 Al472868 AL523506 BF962934 BF960650 BI837618 BF956256 AA487349 BF961475 AA354431 AA115452 AA491157 N75632 BF962141 AL562216 B1754640 N24091 R00062 Api963686 T56529 AU185624 T56460 H97658 B1752843 81819132 AA210796 444726 35032 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 Api745383 AU159045 Ai693500 AW293668 AW371408 BE856107 Api338042 AW188320 AI698246 BE673290 AW297653 AA156532 A1017342 AI916754 AI190644 AI t84302 AA857671 BE857018 AI307420 AI318157 AW204327 AW664668 AW274339 M582788 Al345741 AW301433 Al873468 AW137388 BF718731 BF718413 M877495 BFW1575 Al824693AW849604 AW849405 AW849396 AW849173 BE673179 A ! 611327 AA705753 BE715478 AW849414 AW849399 Al085759 Al140849 T67412 Api889885 AW104647 AI912495 AI889874 AI744241 BE717113 BE717108 BE715564 Al872527 M029457 C00333 Al469558 BE715577 AA045413 BF843813 451184 1531_4 Z99386 AV716301 BE222333 A1949687 BF732426 A1494086 AV721430 AW577332 N68315 BE672030 A1084440 A1250908 N50901 AA757364 BF515264 Al186231 BE466036 AW631313 AA993514 N54411 BG057515 AW013895 N77963 M708723AI273295 N59093M522665 Al871574 AA505521 AA812256 AA553841 AW467057 W68650 AI168772 AA988308 AA910057 AI868258 AA918322 AI335847 AA621494 AA904390 AI760007 AU146694 AV758440 BM142562 N66507 Api674563 AW628584 Al263902 BF223368 Al090490 Al452918 N71423 AA062767 T94332 AA016003 BG681608 AA082426 AA029451 N71873 BF437845 T54154 AV741757 443072 449629_1 AV734838 Al937532 Al032318 AW749500 M091720 437596 2875_1 BC022398 AV743635 AW976922 AW152652 AA910013 AA834629 BG536317 AW849807 AV713062 Api684337 BE044081 AA761490 411962 2307710_1 AA099050 AA099526 T47733 440469 1030831_1 AW753257M886068D61974 450860 40397_1 AK026697 BE938558 BE843975 BE843962 AW304313 AI735759 AA021055 AI769145 AI188319 BF064105 AI677654 AA723627 AA781580 AI611167 BE162152 R77997 BG059091 AV722360 AA370451 AA033786 AV729790 AW953851 AW953855 BE504303 A) 765853 BF059302 AA410685 A) 978745 AA399236 BG149495 BE670366 AI694777 BE503109 AA633474 AI700568 AI432181 AI637714 AW302164 AA196790 Al923519 BE673464 BF437523 A1281974 A1306156 AW418684 AA523952 AA683187 AW075563 AA877270 AW204404 AW771341 Api913892 AW770312 AW242851 AU154858 AA021007 Al521932 M034044 Al760631 R34679 A1915923 A1911609 AW242360 AA059025 AA370450 BF432186 AW862279 AW859976 BE159936 BF514075 81057841 R34781 R77900 AA011413 418481 17381 1 S53911 NM 001773AL572644 AL550179 Api688653 AW025002 AW614285 AU158779 Al017002 M434387 Al252665 Al262206 AU147582 Al144193 AW952860 AI128776 A1017793 AI160509 AA906021 AI149563 AU154950 AI128488 W74409 AI970362 AI141453 AU158772 W58493 BM148338 R73091 AW020496 BI491517 AA022917 AI432610 AI879448 R69099 Api708954 AW014274 AA483672 AA528783 AA912271 Al926942 BE677537 AI874217 AA152376 AA640408 AI287334 BF830285 AA311473 C18678 AA922603 C00910 A1124073 R38730 AA043439 W94644 W58646 AA664247

BE061934 H01096 R69613 A1383162 AU133723 AA311526 R67942 H01097 H72113 R72430 R39494AV744074 AA535925 81759288 B1052385 BF854687 AW608286 AA043438 R72478 AL513811 R69214 AA188435AA054965 412477 8669_2 AI220117 AI857837 AI21837i BM091400 AI304964 AI198508 AI400738 AW571549 AW950042 A1089943 AA437280 AU150878 BF197070 AI267984 BF594181 BF196688 A1433152 A1338921 A1620364 A1280197 AA652531 A1674938 A1342447 A1620350 A1281295 A1148621 N54787 A1338121 Api281153 N51899 Al087072 M954788 AW069054 Al346309 BG529629 Api340135 BF083036 Api167365 AW819657 AA935468 Api467868 AW148701 Al383720 BE047685 AW015498 AA937149 AA708346 AW771478 AW802508 H53334 AW389204 AW798230 Al553922 Al560688 AW950043 AI961682 AV706506 R01853 AA126514 N62757 AI536893 AI926052 AI418720 N99964 AI568933 AI915737 A1080691 AIt 85358 N48996 N68575 H82824 H60037 A1247247 T95664 BF593863 Api749637 AW088541 AA991294 AA887452 A1073726 AA633132 AA629674 M629649M629656 M578595 Al168758 AA804572 A1085786 AA994396 AA991209 AA948663 AA929054 AA927952 T87001 AA928210 AA629296 AW802267 AW384129 BF744400 AA194110 A1382839 AA194837 AA406284 Api250750 R37035 Api525586 W01244 412947 1568055_1 M122277 BE183957 BE183956 432908 452541_1 AF150424 Al861896 M570057 AV738855 434230 41110 1 AFt 19900 NM 018539 AA702388 N53043 BF351064 N70103 AI207469 AA551569 AW383189 W00906 W00935 N54252 414665 23751_3 BG567713AW665841 Al814924 AW978339 AW264036 Al373950AW183157AW082249 Ai201658AI364196 M150743M160873 M453757 BF871646 BF871640 AA565311 AA989511 R10152 AA807154 T77900 AV751591 412446 63467 1 BC021735 AI669212 AL120184 AI769949 8E701002 BE184363 BE819031 BG702238 BF090049 BF963318 BF961912 BF943013 AA934514 AA151245 BF960659 AA987907 Z41449 BF908059 BF908053 BF908049 BE699424 BF908060 BF962832 BF952020 BF963134 B1035538 BF908052 BF908057 BF090026 BF943158 A1632924 BF512340 BF952021 BF960776 BF943437 BF942847 AA68015 F09778 F04816 F02721 AA102645 A1633838 AA617929 BF947001 81035448 BE935876 AW890837 AW898604 BF957405 BF963433 BG704815 434442 111738 1 AA662701 AA633929 AA737415 410453 1027545 1 BE065904 AW749036 BE175748 BE175746 BE175747 BE175745 T64217 454065 517162 1 BE394588 AW024754 BE183167 BE183166 BE378353 434433 111338-1 AA633408 AW749955 AW629759 A1651005 424982 25362_1 AK057547 BG181248M883756 F25670M778128 F27657 F18914 F25171 AA178844 F21556 F25872 F20457 F27617 F36059 F34817 F26967 F25922 F31278 F34666 F01176 F36333 F01226 F27406 F27130 F28742 F24126 F29891 M195955M086351 W69291 F25880 F32791 F31311 F32380 F25216 F19679 F18656 F29700 F24954 F32741 F30404 F35470 F33989 F33141 F36382 F34118 F17714 AA176345 F24700 AA550940 F18617 F16859 F15633 F34675 F16528 F17281 AA086388 F30859 F21852 C02644 F29425 F25286 C03553 F35259 W80691 F16457 F24094 F16783 AA180319 F28443 F17763 F17448 F00542 AA197179AA193012 445029 82093_1 BG566720 AA010276 W92098 BE837833 BF541660 AW889587 AI651246 AI339033 A1078183 AI686504 AA813616 BF056955 R43664 BF509917 AW663717 W95054 AI382907 AI399929 F10511 AA427819 AW269408 BE825398 BG654856 AA03082 AI203007 AW593522 H65211 AA010218 408839 234669 1 AI355222 BF378422 AA366587 8F874552 AW277084 R26970 D79194 R27662 432093 1237011 1 AW972670 AA525808 H28359 H28383 406790 0 0 AA293303 AA492458 AA948195 AI341912 AI436673 436314 142774-1 AA708982 A1095911 A1983409 406997 29867 1 NA 400232 928_1 AL581381 BE220341 A1695121 BG149299 A1205526 A1968389 B1752979 A1291204 A1954763 AA344460 AA344581 BF082319 AU125758 BE825566 AA954549 A1286069 AA948280 BG149854 B 862122 A1024440 A1090013 NM 001895 M55265 BC002615 BC011668 BM452475 AL560958 AU125134 BE408670 AL134963 Al589577 Al952244 AW972197 AW403214 AW069872AI804464 AU123365 Al342226 H50932 AV738572 R94284 BG536938 AI970166 AI858205 J02853 AU131772 BE841258 AW867858 AA419595 AL597675 BF361319 AW877122 AW877060 AW876962 AU126276 AA279620 AA805295 AU132198 AU130091 AI375624 AW183031 AU129003 AI373257 H92896 BE244655 AW028253 AW571546 BI258630 AI807134 AW672915 AW893438 BF036080 AW054815 AW963200 AI797895 AA604241 A1014611 BE092080 BE092076 AA639870 AA714906 N39594 AA173857 AW951102 AW951101 BG823603 AI478558 R32009 AW149282 BG818283 R69507 T29481 BE766560 AI693579 H06201 400307 27110_2 AFW5081 BG193848 454947 1083824_1 AW846590 AW846615 AW846584 AW846592 AW846621 AW846610 417314 20970821 N68168N69188 N90450 410531 1030559 1 H88044 BE156092 AW752953 407394 27110_2 AFW5081 8G193848 434987 121985 1 AW975114 A1096634 AI767001 AA658364 AW517542 448144 48653-1 BC015871 A1521618 A1471709 AW169230 BG539605 Bl058963 Bl058949 BG548393 BG952412 AW842037 AW842040 AW890573 439518 23842_1 AF086341 W76326 W72300 437124 59408_1 AL050013 BG939500 AW969191 AA769925 AI377973 A1625545 AA811365 AA521114 N24705 AI379579 AA424899 AI684671 AA829715 AI453010 N35401 AA677452 AA504340 A1209149 AA883574 A1379062 A1084455 A1280147 AA644327 BF432508 N27873 N47364 N34880 Api147024 T86860 Al219716 M960926 H25544 Bl857123 AW960489 AA599099 AA765246 AA328537 BG434703 AA890373 AA424765 Al292318 M829886 N95742 AI218758 H25588 N36282 AA024987 N36687 B1919187 N49471 AA889970 AW166152 AA468546 A1262504 A1452782 AA554458 AA807080 AA724542 AW102730AA909978 AW118134 AW827241 W56431 BM127381 BF436987 A1016509 AW663972 BM127686 C15552 N63435 N51744 T98800 N56980 BG108636 N49381 R49886 D61278 BI756612 AA508234 R49885 BF850422 432212 6296251 AW972351 AW182936 Al478370 M528309 BG997292 AW137742 AI632006 AA775020 AA961625 W86628 BF112014 AI275423 A1680786 410669 4273 16 AW796921 AW798102 AW805749 AW805872 BF935060 AW794380 BF380449 AW794466 AW794538 434346 MH1094 14 AK056896 AI924216 AI660493 AI984141 AI991272 AA593860 AI983793 AI346155 AI274929 AI281211 AI821178 BC020841 BF352476 BF843140 BF917041 W80832 AA630445 8F350167 BE162052 BE931808 AI572329 BG536379 452467 90115 1 AA026381 AW500815 AI806691 AW502933 AW303573 8E328059 AI201422 8E673566 AW182125 H13705 417553 258857_1 AL545411 AM96369 BF431750 AH30946 W60065 W80663 AA258580 W73279 W76156 W80662 AW058658 Al204699 W60115 N56751 N30878 Al769345 R71250AI363766 R22777 R17009 R27985 R28243 423031 14129_4 AI278995 AW964552 AI885189 AI571775 AI660803 AI299327 AI719401 Z39652 H25636 BF091855 A1218354 A1928704 A1817774 A1885495 A1695453 BF340929AV749610 428193 430_t AF105036 U70663 NM 004235 AF022184 AU141767 AU141110 AL040569 D44830 81011351 AL575805 AI290876 A1014784 AI393429 AI266211 AW074303 AA620711 BF197792 AW008766 D25944 AI687397 AA621680 AV714408 BF446905 BM314505 BF514079 BM314197 AA845201 AW874084 BE720622 AI127241 AA236239 AI679709 AI679135 AI572470 AA573434 AI568487 BE049325 AA687950 BG925989 Al338031 Al365073 A1024576 AA298805 H04001 H45668 BG682146 AL552388 Bl462361 BG547513 BG896863 81256661 415409 34886_1 AK056188 BM455117 BG527027 AA480032 AW993701 AA164703 AL537682 AA836491 AA515961 AL537681 BF437856 AA683484 AW152367 AI769509 AA907521 AW 105404 AI521557 AA670165 AI564471 N22106 AA479060 Al472006 M164704 N30335 AI224391 AA969890 BE856571 Al284716 M918763 M773661 BG942266 AA507486 A1934383 AA502847 AA516351 AA653124 A1360432 R75834 M636111 Al972795 Bl870444 BE891404 Al631952 AI346655AI285030 AA928471 AL520908 AA385324 D80465 D80464 Al554371 Al907655 BF221524 Al091545 M411631 A1028196 AA406581 AA228115 AA227977 BG929224 BF593158 400300 1507 2 AW866366 AI149552 AA010880 AA627121 AA778233 BE936663 BG998642 AA652426 AI240816 N80859 T29383 M11730 NM 004448 X03363 BF155195 BF155196 BG954721 B1052629 BG954765 BG013608 Al907188 BG675003 BG979151 BF743441 BF083392 BF083386 BF756761 BE838913 AL552065 AV697118 BF736873 BG957211 AW175784 Al904229AW175630 R70549 AW175762 Al904242 BG289938 Al376367 M481939 AA446928 Al076724 AW841882 AA985406 BE830620 BE074596 AL552189 Al907227 BE179717 BG998658 BE179931 AW175631 AV689870 AV691022 AA025156 A1624297 AW071 132 BG951486 Api907206 BF348688 A1904222 BG954414 Api590133 AW080151 AA480116 BF360696 Api689419 N75837 AW373844 BF991704 BG222449 81030443 BE698057 BG954850 Api905836 BF984111 AU123871 BF834727 Al904283 Al909847 BF757857 BF923905 BG283493 AA299475 R80150 BG987145 BF837559 BG469759 AA496412 BF758339 BG957192 AW373869 BG952345 BF229957 BE697472 BE697475 AA011005 BG005000 T56558 AA908196 AA716585

424389 1059-4 BG190758AW961118W77994 AA339877 AW845121 AW845129BG181820BE716719A1125483A1161017W73951 A1250771 AA912611 AA339786 BE838286 BE838282 BE716636 AA777158 W94063 BE716628 BE716625 BE838371 BF371044 BE716631 BE716402 433738 593682 1 AL037666 AW607643 AI280025 AL037665 AW291619 A1280142 AA765506 AI684802 AW085941 AI688062 454478 4273 16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 412295 133592 1 Bl757233 BG911321 BF351759 AW244016 AW026834 AW024260 AI420138 AA779354 A1093360 AI934858 AW151292 AI373133 AI335587 AI969728 AA101632 BE218525 At802114 A1783721 AA845265 AW088826 Api832852 F03967 Ai611148 Api720358 AW293764 N91161 R79192 W85852 AW771263 BG820263 BG012864 R74441 R86080 W04256 BE707244 BF899452 BE327552 BE669500 Al492388 Al241532 BF448184 A1209012 AA886528 N70309 AW582776 BF110563 BF448329 BE326537 AW770471 BF444926 BE674147 Al793266 Al991774 Al807726 Al218667 M301750 R44328 415688 1235745_1 AW971218M493942M166963 446515 11382_1 BE178766 Al909166 W79619 AA346208 N54022 R98542AA005419 AA890703 AW510832 BM126988 BF528760 AA858017 BM126698 Al423291 AW173383 AA742205 Ai693060 AA746651 AA490661 AW241710 AI635076 A1073737 AA875841 AA907556 N50889 AW438573 AW273496 AA633604 AW303990 A1685291 A1076127 AW470OB4 A1022394 A1298624 AA253418 W79538 AA719820 AA253398 Al400823AW294450 Al022396 M907775 BF445607 AA699324 AA025643 AW573103 Al167444 AA580002 AW103144 AI640654 AA857115 AA923021 A1066439 A1358865 AA843287 AI824604 AA732370 AW002202 Al219540 AA621697 Al950639 AA904277 Api867527 BF437695 AA808593 Al784144 Al648539 AV752557 AV752603 AA025642 AA764744 AW149075 N30700 H92303 W79523 AI762795 AA282784 H78923 AA252879 H98107 R23754 AA005152 N99239 N74632 H80133 H24710 R38907 R66368 R42466 R52648 H11010 R98493 400229 4623 NMJ) 21724 M24898 X72631 BE550221 BF436030 F18898 AL567477 BG033127 BG747927 BF823716 AA371902 AL137978 AL577786 B1490529 AA021622 AA151679 AA745053 AA454168 R85506 AA016015 424397 893246 1 A1950320 AA340023 406799 0 0 AA908548 431021 10409 1 NM 003312 BC010148AK000862 D87292 BG709214 BF972766 BG740474 Xi771592 B1159859 B1820468 B1523933 A1869664 AA314620 BF724353 BG194276 BG195282 81524679 BF435589 Ai300546 M481682 AW780207 Al800832 Al380540 BE222877 AW300707 AA481445 AW015893 Al381541 AA768558 AI138798 AA432063 AA948713 AI869485 AI307419 AI336589 AI301672 BF055581 Al312785 Al521208 Al927918 Al989759 M78015 BF718621 Al927654 Al795909 Al335381 BF334524 AW007444 AA706797 AA975178 AA884739 AA443837 AA933897 AI826464 AI271737 AA053419 H79704 Api984483 BG952614 BF345358 AW083336 AA643660 AI478232 AA603071 BE714413 AW078660 AW070418 R02364 BG925951 AL568823 AA053459 AA446748 BG954446 BF760569 427841 12616_8 W74622 BF055071 AWI 35949 All 8484 A1393557 A1830476 AA416697 A1400728 AW183266 T83655 AW883367 A1963037 BF964042 440526 1078274 1 A1832243 AI742643 AW839701 AA888497 446576 629517 1 BI517686 T89902 B1518252 AI659477 T89628 H22349 408198 102854. 1 AA132859AA131111AA053057 406800 00 AA505535 422959 MH9053 AJ400845 Al954159AL041618AI028269 M769325 AW780241 AW129462 Al271476 BF798303 AA836991 AW273346 Al436321 Al375545 AL040967 AA889495 Ai922524 M598667 M423804 AL040910 N80292 A1954063 A1923968 A1400578 AA748499 BE677845 AW020788 AA860230 AW519209 AA767391 A1860419 AA476935 AW452389 A1017695 AA806940 BI497005 A1051533 AI650706 AI811516 AA609569 A1439198 BF430946 AA749268 Al624860 Al764422 Bl491753 Al206880 BE671796 AI431957 AI187038 AI678429 AI273421 AA897667 AA586499 BE241923 AF161081 NM013440 BE073169 Al700673 AV699081 AV684786 AV688081 AV689220AV689216M132636 BF086186 BF917106AV762653 Bl064033 BE168145 M778650 AI984255 W69468 AA132452 N53166 AI949278 AW168519 F28686 AA908333 F37181 B1002729 TABLE 64C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank identifier (GI) numbers. Dunham, et refers to the publication entitled'The DNA sequence of human chromosome 2Z Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Nt_position : Indicates nucleotide positions of predicted exons. Pkey Ref Strand NLposition 401781 7249190 Minus 83215-83435, 83531-83656, 83740-83901, 8423 401780 7249190 Minus 28397-28617, 28920-29045. 29135-29296, 2941 401203 9743387 Minus 172961-173056, 173868-173928 401785 7249190 Minus 16577G165996, 166189-166314, 166408-16656 402294 2282012 Minus 2575-3000 402845 9369286 Plus 160451-160617, 160788-161009 403710 6437516 Plus 27413-28978 401760 9929699 Plus 83126-83250. 85320-85540, 94719-95287 403593 6862650 Minus 62554-62712, 69449-69602 400494 9714719 Plus 169845170272 400835 8954121 Plus 89366-89622 401905 8671966 Plus 153965-154441, 156599-156319 403180 7523976 Minus 63603-63759 401747 9789672 Minus 11859&118816, t19119-119244, 119609-11976 403108 8980955 Plus 93253-93667 404996 6007890 Plus 37999-38145, 38652-38998, 39727-39872, 4055 402575 9884830 Minus 109742-109883 402338 6957691 Minus 36915-37250 401205 9743388 Plus 167373-167433. 167936-168031 401192 9719502 Minus 69559-70101 406400 9256298 Plus 1553-1712, 1878-2140. 4252-4385, 5922-6077 404246 7406725 Plus 82477-82628, 82721-82817, 82910-83071, 8314 401131 8699812 Minus 94802-94987. 95804-95887, 96323-96487, 9759 406467 9795551 Plus 182212-182958 403105 8980016 Minus 145287-145744 401429 8217890 Minus 86946-87579 402991 7631064 Minus 161294-161579 402956 9408727 Minus 135901-136035 406587 8189273 Minus 120577-120718 402075 8117407 Plus 121907-122035, 122804-122921, 124019-12416 404175 9931117 Minus 107420-107547, 109625-109796 TABLE 65A : ABOUT 838 GENES DOWNREGULATED IN BENIGN NEVI RELATIVE TO NORMAL SKIN Table 65A lists about 838 genes downregulated in benign nevi relative to normal skin. Genes were selected from 59680 probesets on the Eos/AffymeUix Hu03 Genechip array. Gene expression data for each probeset obtained from this analysis was expressed as average intensity (Al), a normalized value rejecting the relative level of mRNA expression.

Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene title R1 : 90th percentile of normal skin Als divided by the average of benign nevi Als R2 : 90th percent of normal skin Als divided by the average of benign nevi Als, where the 1 5th percentile ot nommal 6ssue Als was subtracted from both the numerator and denominator Pkey ExAccn UnigenelD Unigene Title R1 R2 420813 X51501 Hs. 99949 prolactin-induced protein 27. 72 28. 59 408591 AF015224 Hs. 46452 mammaglobin 1 26. 40 28. 34 422166 W72424 Hs. 112405 SIOO calcium-binding protein A9 (calgran 21. 33 21. 57 418026 BE379727 Hs. 83213 fatty acid binding protein 4, adipocyte 18. 06 18. 96 429441 AJ224172 Hs. 204096 lipophilin B (uteroglobin family member) 16. 61 18. 06 428087 AA100573 Hs. 182421 troponin C2, fast 14. 70 14. 60 407245 X90568 Hs. 172004 fifin 13. 08 13. 84 428824 W23624 Hs. 173059 ESTs 12. 89 13. 36 428330 L22524 Hs. 2256 matrix metaloproteinase 7 (matrilysin, 12. 78 13. 98 444816 Z48633 Hs. 283742 H. sapiensmRNAforretrotransposon 12. 26 9. 86 453309 A1791809 Hs. 32949 defensin, beta 1 12. 02 10. 62 423024 AA593731 Hs. 325823 ESTs, ModeratelysimilartoALU5 HUivANA 11. 90 10. 86 446227 AI281459 Hs. 270114 ESTs 11. 79 12. 32 413902 AU076743 Hs. 75613 CD36 antigen (collagen type I receptor, 11. 19 10. 82 432877 AW974111 Hs. 292477 ESTs 11. 18 11. 30 426752 X69490 Hs. 172004 titin 10. 97 12. 63 427899 AA829286 Hs. 332053 serum amyloid A1 10. 85 13. 85 407230 AA157857 Hs. 182265 keratin 19 10. 79 11. 40 451029 AA852097 Hs. 25829 ras-related protein 10. 78 10. 35 421296 NM002666 Hs. 103253 perilipin 10. 73 11. 25 431211 M86849 Hs. 323733 gap junction protein, beta 2, 26kD (conn 10. 66 7. 24 422633 X56832 Hs. 118804 enolase 3, (beta, muscle) 10. 57 9. 92 405121 mitogen-activated protein kinase 8 inter 10. 41 10. 54 450912 AW939251 Hs. 25647 v-fos FBJ munne osteosarcoma viral onco 10. 26 23. 20 420859 AW468397 Hs. 100000 S100 calcium-binding protein A8 (calgran 10. 25 9. 45 410850 AW362867 Hs. 302738 Homo sapiens cDNA : FU21425 fis, clone C 10. 15 9. 88 416931 D45371 Hs. 80485 adiposemostabundantgenetranscript1 10. 13 11. 58 447966 AA340605 Hs. 105887 ESTs, Weakly similar to Homolog of rat Z 10. 09 5. 51 401203 Target Exon 9. 95 10. 74 425545 N98529 Hs. 158295 Homo sapiens, clone MGC : 12401, mRNA, com 9. 94 11. 47 425580 L11144 Hs. 1907 galanin 9. 66 6. 60 414092 Z14244 Hs. 75752 cytochrome c oxidase subunit Vilb 9. 45 6. 44 420919 M57892 Hs. 100322 carbonic anhydrase VI 9. 41 10. 49 443162 T49951 Hs. 9029 DKFZP434G032 protein 9. 36 10. 58 430154 AW583058 Hs. 234726 serine (orcysteine) proteinaseinhibito 8. 91 10. 27 452322 BE566343 Hs. 28988 gfutaredoxin (thioltransferase) 8. 90 7. 26 430071 AA355986 Hs. 232068 transcription factor 8 (represses intert 8. 86 8. 94 417240 N57568 Hs. 48028 EST 8. 81 18. 90 415477 NM_002228 Hs. 78465 v-junavian sarcoma virus 17 oncogene ho 8. 72 6. 86 430130 AL137311 Hs. 234074 HomosapiensmRNA ; cDNADKFZp761G02121 (8. 39 10. 26 408491 A1088063 Hs. 7882 ESTs 8. 00 8. 20 414657 AA424074 Hs. 76780 protein phosphatase 1, regulatory (inhib 7. 99 8. 14 409738 BE222975 Hs. 56205 insulin induced gene 1 7. 95 7. 75 428221 U96781 Hs. 183075 ATPase, Ca transporting, cardiac muscle, 7. 89 8. 86 451831 NM 001674 Hs. 460 activating transcription factor 3 7. 79 7. 51 410867 X63556 Hs. 750 fibnilin 1 (Marfan syndnome) 7. 76 7. 55 444984 H15474 Hs. 132898 fatty acid desaturase 1 7. 75 5. 64 413076 U10564 Hs. 75188 wee1 (S. pombe) homolog 7. 68 5. 65 410532 T53088 Hs. 155376 hemoglobin, beta 7. 64 4. 73 442757 A1739528 Hs. 28345 ESTs 7. 62 7. 66 412047 AA934589 Hs. 49696 ESTs 7. 61 7. 48 410052 AA525225 Hs. 334630 Homo sapiens cDNA FU14462 fis, clone MA 7. 52 7. 28 439394 AA149250 Hs. 56105 ESTs 7. 52 6. 72 442941 AU076728 Hs. 8867 cysteine-rich. angiogenic inducer, 61 7. 51 6. 27 450680 AF131784 Hs. 25318 Homosapiensclone25194mRNAsequence 7. 51 4. 10 456525 AW468397 Hs. 100000 S100 calcium-binding protein A8 (calgran 7. 49 8. 08 407334 AA494411 Hs. 296031 ESTs 7. 48 6. 78 414449 AA557660 Hs. 76152 decorin 7. 39 8. 30 432305 M62402 Hs. 274313 insulin-like growth factor binding prote 7. 38 8. 79 407328 AA508857 ESTs, Weakly similar to ALU1HUMANALUS 7. 35 7. 20 431842 NM_005764 Hs. 271473 epithelia protein up-regulated in carci 7. 06 6. 93 426488 X03350 Hs. 4 alcohol dehydrogenase 1B (class 1), beta 7. 03 7. 85 445502 AW379160 Hs. 12813 DKFZP434J214 protein 7. 01 6. 63 419285 D31887 Hs. 89868 KIAA0062 protein 7. 01 5. 82 409024 AW883529 Hs. 173830 ESTs, Weakly similar to ALU7 HUMAN ALU S 6. 99 4. 58 422963 M79141 Hs. 13234 ESTs 6. 99 4. 08 447918 Al129320 Hs. 115175 ESTs, Highly similar to JC5818 gamma-act 6. 98 6. 49 410530 M25809 Hs. 64173 ATPase, H transporting, lysosomal (vacuo 6. 96 7. 04 444381 BE387335 Hs. 283713 ESTs, Weakly similar to S64054 hypotheti 6. 95 8. 08 417993 AW963705 Hs. 301183 molecule possessing ankydn repeats indu 6. 94 7. 12 443060 D78874 Hs. 8944 procoilagen C-endopept'dase enhancer 2 6. 94 6. 79 427890 AA435761 ESTs 6. 94 6. 68 444207 Al565004 cathepsin D (Iysosomå aspartyl protease 6. 93 4. 66 442083 R50192 Hs. 165062 ESTs 6. 92 6. 92

441633 AW958544 Hs. 112242 normal mucosa of esophæus specific 1 6. 87 5. 07 407722 BE252241 Hs. 38041 pyridoxal (pyridoxine, vitamin B6) kinas 6. 87 4. 99 444051 N48373 Hs. 10247 activated feucocyte cell adhesion miecu 6. 84 5. 33 414841 H55601 Hs. 77490 glutathione S-transferase theta 1 6. 84 3. 47 430314 AA369601 Hs. 239138 pre-B-ceilcolony-enhancingfactor 6. 79 7. 14 427704 AW971063 Hs. 292882 ESTs 6. 72 7. 30 431713 AK000388 Hs. 267997 EHM2gene 6. 72 7. 10 451253 H48299 Hs. 26126 claudin 10 6. 71 7. 20 453187 Al161383 Hs. 34549 ESTs, Highly similar to S94541 1 clone 4 6. 68 3. 02 400304 AF005082 Hs. 113261 Homo sapiens skin-specific protein (xp33 6. 64 6. 08 434625 W01370 Hs. 46824 ESTs 6. 61 6. 92 408063 BE086548 Hs. 42346 calcineurin-binding protein calsarcin-1 6. 60 7. 29 425280 U31519 Hs. 1872 phosphoenolpyruvate carboxykinase t (soi 6. 55 6. 79 411388 X72925 Hs. 69752 desmocollin 1 6. 55 3. 44 413731 BE243845 Hs. 75511 connective tissue growth factor 6. 52 4. 86 455863 AA907305 Hs. 36475 ESTs 6. 50 4. 24 412247 AF022375 Hs. 73793 vascular endothelial growth factor 6. 49 4. 56 407102 AA007629 glyceml-3-phosphate dehydrogenase I (so 6. 47 7. 23 421407 T82331 Hs. 182278 ESTs, Weakly similar to CGHU6C collagen 6. 47 6. 55 406867 AA157857 Hs. 182265 keratin 19 6. 44 6. 23 429504 X99133 Hs. 204238 lipocalin 2 (oncogene 24p3) (NGAL) 6. 43 6. 79 446945 A1193115 Hs. 16611 tumor protein 052-like 1 6. 43 5. 66 413172 M38180 Hs. 38586 hydroxy-detta-5-steroid dehydrogenase. 3 6. 39 7. 09 407395 AF005082 gb : Homo sapiens skin-specific protein (x 6. 39 4. 76 450626 AW190989 Hs. 1508 insulin-degrading enzyme 6. 37 6. 22 450713 AL133611 Hs. 25362 HomosapiensmRNA ; cDNA DKFZp43401317 (f 6. 37 4. 91 437596 AA761490 ESTs, Moderately similar to S65657 alpha 6. 35 5. 31 430191 Al149880 Hs. 188809 ESTs 6. 34 6. 15 433713 AW976511 Hs. 112592 ESTs 6. 34 5. 67 420107 AL043980 Hs. 7886 pellino (Drosophila) homolog 1 6. 33 6. 39 422069 AJ010063 Hs. 343603 titin-cap (tetethonin) 6. 33 5. 77 437176 AW176909 Hs. 42346 calcineurin-binding protein calsarcin-1 6. 30 5. 45 433412 AV653729 Hs. 8185 CGI-44 protein ; sulfide dehydrogenase li 6. 29 6. 68 447335 BE617695 Hs. 286192 hypothetical protein FU20940 6. 28 10. 35 413063 AL035737 Hs. 75184 chitinase 3-like1 (cartilage glycoprote 6. 21 5. 98 440116 At798851 hemoglobin, gamma G 6. 18 6. 86 454229 AW957744 Hs. 278469 tacnmatprotine rich protein 6. 17 6. 54 441188 AW292830 Hs. 255609 ESTs 6. 12 6. 68 451144 AW956103 Hs. 61712 pyruvate dehydrogenase kinase, isoenzyme 6. 12 5. 79 431319 AA873350 Hs. 302232 ESTs 6. 11 7. 91 442498 U54617 Hs. 8364 Homo sapiens pyruvate dehydrogenase kina 6. 10 5. 63 414555 N98569 Hs. 76422 phospholipase A2, group IIA (platelets, 6. 08 6. 96 418321 D63477 Hs. 84087 KIM0143 protein 6. 08 4. 71 443072 Api937532 gb : wp78dO2. x1 NCl_CGAP_Bm25 Homo sapien 6. 07 5. 48 423712 W46802 Hs. 81988 disabled (Drosophila) homolog 2 (mitogen 6. 04 5. 81 442679 R53718 hypothetical protein FLJ10659 6. 03 5. 67 424824 Al217440 Hs. 143873 ESTs 6. 02 5. 46 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy 6. 01 7. 05 428358 AA993222 Hs. 101915 Stargardt disease 3 (autosomat dominant) 5. 94 7. 17 430821 AA487264 Hs. 154974 Homo sapiens mRNA ; cDNADKFZp667N064 (fr 5. 92 5. 79 424670 W61215 Hs. 116651 epithelial V-like anGgen 1 5. 92 5. 63 424673 AA345051 Hs. 294092 ESTs, Weakly similar to 138022 hypotheti 5. 91 6. 81 418205 L21715 Hs-83760 troponin 1, skeletal, fast 5. 91 6. 95 400440 X83957 Hs. 83870 nebulin 5. 89 7. 01 444239 R57988 Hs. 10706 epithelial protein lost in neoplasm beta 5. 89 5. 49 419517 AF052107 Hs. 90797 Homo sapiens clone 23620 mRNA sequence 5. 86 5. 88 432626 AA471098 Hs-278544 acetyl-Coenzyme A acelvansferase 2 (a 5. 86 5. 58 407584 W25945 Hs. 8173 hypothetica) protein FLJ10803 5. 81 5. 09 449335 AW150717 Hs. 345728 STAT induced STAT inhibitor 3 5. 79 6. 33 445607 AA488107 Hs. 30156 ESTs, Weakly similar to unnamed protein 5. 78 5. 91 424571 BE379766 polymerase (RNA) II (DNA directed) polyp 5. 78 3. 74 412630 AA738437 Hs. 26226 Homo sapiens cDNA : FLJ21286 fis, clone C 5. 76 4. 21 408819 AW163483 Hs. 48320 double ring-finger protein, Dorfin 5. 71 4. 59 433027 AF191018 Hs. 279923 putative nucleotide binding protein, est 5. 70 4. 71 406704 M21665 Hs. 929 myosin, heavy polypeptide 7, Cardiac mus 5. 68 6. 12 408515 Al289507 Hs. 299883 hypothe6cå protein FW23399 5. 67 4. 81 443827 A1087867 Hs. 134667 ESTs 5. 67 5. 54 429693 BE254962 Hs. 211612 SEC24 (S. cerevisiae) related gene famil 5. 67 4. 12 427373 AB007972 Hs. 130760 myosinphosphatase, targetsubunit2 5. 66 4. 27 428666 AL080190 Hs. 189242 Homo sapiens mRNA ; cDNA DKFZp434A202 (fr 5. 65 5. 16 421834 BE543205 Hs. 288771 DKFZP586A0522 protein 5. 65 4. 52 427081 At474533 Hs. 170528 ESTs, Moderately simiiar to ALUCHUMAN ! 5. 65 4. 81 419731 S47242 Hs. 92909 SON DNA binding protein 5. 64 3. 77 420787 AA564248 ESTs, Weakly similar to 138022 hypothefi 5. 64 3. 27 420682 A1380552 Hs. 88602 ESTs 5. 63 4. 13 410541 AA065003 Hs. 64179 syntenin-2 protein 5. 62 5. 84 431360 Nom-000427 Hs. 251680 loricrin 5. 61 5. 14 418127 BE243982 Hs. 83532 membrane cofactor protein (CD46, trophob 5. 61 4. 28 430332 R51790 Hs. 239483 Human clone 23933 mRNA sequence 5. 60 5. 76 427850 AA416756 Hs. 161051 ESTs, Moderately similar to ALU6 HUMAN A 5. 51 16. 04 429679 NM006290 Hs. 211600 tumor necrosis factor, alpha-induced pro 5. 49 5. 28 422082 AA016188 Hs. 111244 hypothetical protein 5. 49 5. 23 419461 A1452601 Hs. 288869 nuclear receptor subfamily 2, group F, m 5. 49 4. 40

430714 AA484757 Hs. 287601 Homo sapiens CDNA FU 13830 fis, clone TH 5. 48 5. 38 407744 AB020629 Hs. 38095 ATP-binding cassette, sub-family A (ABC1 5. 46 5. 11 400494 ENSP00000238970' : CIG30 (Fragment). 5. 45 3. 63 415062 H45100 Hs. 49753 uveal autoantigen with coiled coil domai 5. 43 4. 25 449291 BE176893 Hs. 23440 KIAA1105 protein 5. 41 3. 82 435538 AB011540 Hs. 4930 low density lipoprotein receptor-related 5. 41 2. 62 417035 AA192455 Hs. 22968 Homo sapiens clone IMAGE : 451939, mRNAse 5. 40 5. 40 434535 A1611729 Hs. 167619 ESTs, Moderately similar to ALUC_HUMAN ! 5. 40 5. 20 408085 N25929 Hs. 342849 ADP-ribosylation factor-like 5 5. 39 4. 59 413778 AA090235 Hs. 75535 myosin, light polypeptide 2, regulatory, 5. 37 14. 96 436090 A1640635 Hs. 332879 EST 5. 37 5. 33 406805 A1686003 Hs. 296031 ESTs 5. 35 5. 49 426510 AW861225 Hs. 251928 BANP homolog, SMAR1 homolog 5. 35 6. 83 406706 X03740 Hs. 231581 myosin, heavy polypepGde 1, skeletal mu 5. 34 7. 50 456332 AA228357 gb : nc39dO5. ri NCl_CGAP_Pr2Homosapiens 5. 34 4. 88 421999 U50535 Hs. 110630 HumanBRCA2region, mRNAsequenceCG006 5. 34 4. 75 418479 AA829976 mannosidase, alpha, class 1A, member 2 5. 34 3. 59 417059 AL037672 Hs. 81071 extracellular matrix protein 1 5. 34 4. 71 424008 R02740 Hs. 137555 putative chemokine receptor, GTP-binding 5. 34 4. 75 415694 AW194301 Hs. 339283 HumanDNAsequencehomcloneRP1-187J11 5. 34 8. 69 452747 BE153855 Hs. 61460 lg superfamily receptor LNIR 5. 31 5. 81 449271 AW338067 Hs. 7869 Homo sapiens cONA FW t 1946 fis, clone HE 5. 30 4. 35 437135 AL038624 Hs. 208752 ESTs, Weakiy similar to ALU8HUMANALUS 5. 29 4. 92 419925 AA159850 Hs. 93765 lipoma HMGIC fusion partner 5. 29 5. 02 415192 D17793 Hs. 78183 aldo-keto reductase family 1, member C3 5. 28 5. 33 453999 BE328153 Hs. 240087 ESTs 5. 28 3. 40 408958 T99607 Hs. 49346 signal recognition particle 541cD 5. 28 2. 84 452496 AA114926 Hs. 169531 ESTs 5. 28 5. 48 424058 AL121516 Hs. 138617 thyroid hormone receptor interactor 12 5. 27 3. 72 443265 A1916207 Hs. 9167 SH3 domain binding glutamic acid-rich pr 5. 26 4. 62 407013 U35637 Hs. 83870 gb : Human nebulin mRNA, partial cds 5. 26 6. 21 414602 AW630088 Hs. 76550 Homo sapiens mRNA ; cDNA DKFZp564B1264 (f 5. 26 4. 21 410284 U50939 Hs. 61828 amyloid beta precursor protein-binding p 5. 26 4. 43 445107 A1208121 Hs. 147313 ESTs, Weakly similar to 138022 hypothefi 5. 25 5. 61 446267 AW450103 Hs. 151124 ESTs 5. 24 4. 44 422278 AF072873 Hs. 114218 frizzled (Drosophila) homolog 6 5. 23 3. 14 448585 AB020676 Hs. 21543 KIAA0869 protein 5. 23 6. 21 421993 R22497 Hs. 110571 growth arrest and DNA-damage-inducible, 5. 22 6. 84 414407 AA147026 Hs. 76704 ESTs 5. 22 5. 29 423720 AL044191 Hs. 23388 hypothefical protein DKFZp434F0318 5. 22 5. 85 415997 NM_003590 Hs. 78946 cultin 3 5. 21 3. 66 411531 AB014511 Hs. 70604 ATPase, Class 11, type 9A 5. 21 3. 95 441619 NM 014056 Hs. 7917 DKFZP564K247 protein 5. 20 4. 38 435232 NM001262 Hs. 4854 cydin-dependentkinase inhibitor 2C (pt 5. 19 4. 52 415167 AA160784 Hs. 26410 ESTs 5. 19 3. 13 431416 AA532718 Hs. 178604 ESTs 5. 18 5. 38 439995 AL137480 Hs. 6834 KIAA1014 protein 5. 17 3. 14 416784 AA334592 Hs. 79914 lumican 5. 17 6. 18 446082 A1274139 Hs. 156452 ESTs 5. 16 5. 14 400196 Eos Control 5. 16 5. 05 414525 C14904 Hs. 45184 Homo sapiens CDNA FLJ 12284 fis, clone MA 5. 16 4. 31 414242 AA749230 Hs. 26433 dolichyi-phosphate (UDP-N-acetylglucosam 5. 15 4. 89 430699 AW969847 Hs. 292718 ESTs, WeaklysimilartoRET2_HUMANRETIN 5. 14 5. 22 440383 AA884208 Hs. 30484 ESTs 5. 13 5. 09 431628 AF146277 CD2-associated protein 5. 13 5. 03 407047 X65965 gb : H. sapiens SOD-2 gene for manganese su 5. 13 4. 31 433688 AA628467 Hs. 112572 Homo sapiens cDNA FU14130 fis, clone MA 5. 12 3. 57 437704 AA766142 Hs. 131810 ESTs, ModeratelysimilartoALU1_HUMANA 5. 12 3. 30 426101 AL049987 HomosapiensmRNA ; cDNADKFZp564F112 (fr 5. 11 6. 08 428297 AA236291 Hs. 183583 senne (or cysteine) proteinase inhibito 5. 10 4. 31 416382 D86985 Hs. 79276 KlM023Zgene product 5. 10 3. 79 437150 R51407 Hs. 77910 3-hydroxy-3-methylglutaryl-Coenzym A sy 5. 10 6. 58 454947 AW846590 gb : QVO-CT0180-01109902SdO7CT0180Homo 5. 09 4. 82 434647 W74158 Hs. 103189 lipopolysaccharide specific response-68 5. 09 4. 90 418730 AA091027 Hs. 325625 Homo sapiens clone 23938 mRNA sequence 5. 09 3. 46 449338 H73444 Hs. 394 adrenomedullin 5. 09 6. 26 438962 BE046594 gb : hn41c11. x1 NCl_CGAp_RDF2Homosapiens 5. 08 5. 60 431693 A1459519 serine (or cysteine). proteinase inhibito 5. 07 2. 83 420583 H77859 Hs. 65450 reticu) 4 5. 06 6. 71 431048 R50253 Hs. 249129 cell death-inducing DFFA-like effector a 5. 06 6. 06 432125 AW972667 Hs. 183006 Homo sapiens cDNA FU 12300 fis, clone MA 5. 05 6. 32 447945 A1922838 Hs. 9670 ESTs, Weakly similar to ALU1 HUMAN ALU S 5. 05 3. 72 442547 AA306997 Hs. 217484 ESTs, Weakly similar to ALUL-HUMAN ALU S 5. 05 2. 86 414176 BE140638 Hs. 75794 EDG-2 (endothelial differentiation, lys 5. 03 4. 43 445263 H57646 Hs. 42586 KIAA1560 protein 5. 03 6. 67 448490 AI523897 Hs. 271692 ESTs. Weakly similar to 138022 hypothefi 5. 03 4. 88 450515 AW304226 biphenylhydrolase-like (sennehydnolas 5. 03 4. 36 440624 AF017987 Hs. 7306 secreted frizzled-related protein 1 5. 01 5. 48 417165 R80137 Hs. 302738 HomosapienscDNA : FLJ21425 fis, clone C 5. 01 5. 61 417640 030857 Hs. 82353 protein C receptor, endothelial (EPCR) 5. 01 5. 32 413475 AW021488 Hs. 26981 ESTs 5. 01 3. 90 414792 BE314949 Hs. 87128 hypothetical protein FW23309 5. 00 4. 54 424074 A1902456 Hs. 210761 ESTs, Weakly similar to 138022 hypotheb 5. 00 3. 19

424620 AA101043 Hs. 151254 kallikein7 (chymotlyp6cstratumcom 4. 99 6. 25 439039 A1656707 Hs. 48713 ESTs 4. 99 6. 60 422305 Api928242 Hs. 293438 ESTs, Highly similar to AFt984881 trans 4. 98 9. 59 410579 AK001628 Hs. 64691 KIAA0483 protein 4. 98 4. 52 449710 AA002207 Hs. 17385 Homo sapiens clone IMAGE : 119716, mRNAse 4. 98 3. 84 434230 AA551569 hypothetical protein PRO2822 4. 98 3. 63 426468 AA379306 Hs. 117558 ESTs 4. 98 3. 56 421690 AW162667 Hs. 106857 calbindin 2, (29kD, calretinin) 4. 96 6. 41 448144 AW169230 ESTs, Moderately similar to PC4259 feni 4. 96 3. 28 412129 M21984 Hs. 73454 troponin T3, skeletal, fast 4. 96 5. 75 450071 AA018283 Hs. 24359 Homo sapiens DNA 1174 fis. done PL 4. 96 3. 21 433934 AW273261 Hs. 216292 ESTs 4. 95 4. 39 446320 AF126245 Hs. 14791 acyl-Coenzyme A dehydrogenase family, me 4. 95 4. 01 446161 AA628206 Hs. 14125 p53 regulated PA26 nuclear protein 4. 94 4. 54 453225 BE258769 acetyl-Coenzyme A acyltransferase 2 (mit 4. 94 4. 49 444476 AF020038 Hs. 11223 isocitratedehydnzgenase1 (NADP), solub 4. 94 4. 19 445493 Ai915771 metallothionein tE (functional) 4. 93 5. 68 422292 Api815733 Hs. 114360 transforminggrowthfactorbeta-stimutat 4. 93 5. 47 417054 AF017060 aldehyde oxidase 1 4. 93 4. 51 425917 W28517 Hs. 117167 HomosapienscDNA FW23067fis, cbne L 4. 93 3. 34 408681 AW953853 Hs. 281462 ESTs, Weakly similar to 138022 hypotheti 4. 93 5. 61 451267 A1033894 Hs. 117865 solutecarierfamily17 (anionisugartr 4. 92 3. 27 447137 AW970192 Hs. 171942 ras responsive element binding protein 1 4. 91 4. 26 427451 Al690916 Hs. 178137 transducerof ERBB2, 1 4. 90 6. 00 432314 AA533447 Hs. 312989 ESTs 4. 90 3. 79 440692 AL031591 Hs. 7370 phosphotidytinosito) transfer protein, b 4. 89 3. 71 428594 BE387236 Hs. 75415 beta-2-microglobulin 4. 89 3. 27 437802 A1475995 Hs. 122910 ESTs 4. 87 4. 06 437974 T74445 Hs. 5957 Homosapiensdone24416mRNAsequence 4. 86 6. 54 427156 BE621719 Hs. 173802 KIAA0603 gene product 4. 86 5. 15 433179 AW362945 Hs. 162459 ESTs 4. 86 5. 50 428957 NM_003881 Hs. 194679 WNT1 inducible signaling pathway protein 4. 85 5. 29 453855 AA039576 Hs. 37858 ESTs, Weakly similar to ALUB HUMAN ! ! ! ! 4. 85 3. 59 433143 BE552155 Hs. 294035 ESTs, Weakly similar to ALU5_HUMAN ALU S 4. 85 3. 45 429279 AB018271 Hs. 198689 KIAA0728 protein 4. 83 3. 80 445773 H73456 Hs. 13299 HomosapiensmRNA cDNADKFZp761M0111 (f 4. 82 4. 20 416349 X69089 Hs. 79227 myomesin (M-protein) 2 (165kD) 4. 82 4. 01 408138 AA535740 tumor protein p53-binding protein, 1 4. 81 4. 19 432566 AW439330 Hs. 256889 ESTs, Weakly similar to 2109260A B cell 4. 80 3. 99 444677 AL110212 Hs. 301005 purine-rich element binding protein B 4. 80 3. 50 422658 AF231981 Hs. 250175 homolog of yeast long chain polyunsatura 4. 80 10. 20 431926 AW972724 gb : EST384816 MAGE resequences, MAGL Homo 4. 79 4. 39 407839 AA045144 Hs. 161566 ESTs 4. 79 2. 98 421998 R74441 poly (A)-binding protein, nuclear 1 4. 77 4. 78 416987 D86957 Hs. 80712 KIAA0202 protein 4. 76 3. 99 448988 Y09763 Hs. 22785 gamma-aminobutyric acid (GABA) A recepto 4. 76 7. 59 440494 BE618768 Hs. 7232 acetyl-Coenzyme A carboxylase alpha 4. 75 4. 38 453180 N46243 Hs. 110373 ESTs, Highly similar to T42626 secreted 4. 75 3. 92 413276 Z24725 Hs. 75260 mitogen inducible 2 4. 75 5. 68 437239 AW503395 Hs. 5541 ATPase, Ca transporting, ubiquitous 4. 74 5. 57 414622 AI752666 Hs. 76669 nicoinamide N-methyltransferase 4. 74 11. 58 429587 AA283969 Hs. 334706 Homo sapiens cDNA FLJ11801 fis, clone HE 4. 74 3. 79 407242 M18728 gb : Human nonspecific crossreacting antig 4. 73 4. 88 445229 BE276013 Hs. 172364 HomosapiensmRNAforFW00086protein, 4. 73 4. 79 447429 AB007920 Hs. 18586 KIAA0451 gene product 4. 72 2. 38 444930 BE185536 Hs. 301183 moleculepossessingankyrinepeatsindu 4. 71 5. 10 414848 A1803447 Hs. 77496 smallnuclearribonucleoproteinpolypept 4. 71 2. 51 439652 W67826 Hs. 55412 ESTs, WeakiysimilartoK1CJ HUMANKERAT 4. 70 6. 13 453145 R63438 Hs. 183454 Homo sapiens cDNA FLJ14883 fis, clone PL 4. 70 3. 06 421302 T34462 Hs. 103291 neuri6n 4. 69 4. 96 425118 AU076611 Hs. 154672 methylenetetrahydrofolatedehydrogenase 4. 68 5. 01 448079 R76981 thyroid hormone receptor-associated prot 4. 68 3. 97 434558 AW264102 Hs. 39168 ESTs 4. 67 3. 42 408239 AA053401 ESTs, Moderately similar to ALU7 HUMAN A 4. 67 6. 17 454416 A1912097 Hs. 163208 ESTs 4. 66 3. 97 427215 AW246148 Hs. 268371 hypothetical protein FLJ20274 4. 66 3. 37 451583 Al653797 Hs. 24133 ESTs 4. 65 3. 81 446525 AW967069 Hs. 211556 hypothetical protein MGC5487 4. 65 6. 14 436176 AL121422 Hs. 54900 serologically defined colon cancer antg 4. 65 3. 65 450528 NM014072 Hs. 25063 PR00461 protein 4. 64 2. 99 417259 AW903838 Hs. 81800 chondroifin sulfate proteoglycan 2 (vers 4. 64 4. 72 408741 M73720 Hs. 646 carboxypeptidase A3 (mast cell) 4. 63 5. 55 417733 AL048678 Hs. 82503 H. sapiensmRNAfor3UTRofunknownprot 4. 63 5. 04 436280 A1690734 Homo sapiens cDNA : FLJ22562 fis, clone H 4. 63 3. 55 428744 BE267033 Hs. 192853 ubiquitin-conjugating enzyme E2G 2 (homo 4. 63 2. 85 427007 NM 006283 Hs. 173159 transforming, acidic coiled-coil contain 4. 63 3. 00 453767 AB011792 Hs. 35094 extracellular matrix protein 2, female o 4. 62 5. 14 449971 AA807346 Hs. 288581 Homo sapiens cDNA FLJ 14296 fis, clone PL 4. 62 4. 49 409598 NM014018 Hs. 55097 mitochondnal ribosomal protein S28 4. 62 3. 56 413305 NM000426 Hs. 323511 HomosapienscDNA : FLJ23176 fis, clone L 4. 62 4. 24 412577 Z22968 Hs. 74076 CD163 antigen 4. 61 8. 03 424046 AF027866 Hs. 138202 serine (or cysteine) proteinase inhibito 4. 61 6. 86 452289 BE568205 Hs. 28827 mitogen-activated protein kinase kinase 4. 61 4. 33

458971 AL119206 Hs. 101874 ESTs Weakly similar to ALU1 HUMAN ALU S 4. 61 4. 16 433256 AW604447 Hs. 339408 ESTs Weakly similar to S26689 hypotheti 4. 61 3. 58 440596 H13032 Hs. 103378 hypothetical protein MGC11034 4. 61 3. 22 427919 AA173942 Hs. 326416 Homo sapiens mRNA ; cDNA DKFZp564H1916 (t 4. 60 4. 74 424651 A1493206 Hs. 32425 ESTs 4. 60 4. 11 436701 AW959032 ESTs Moderately similar to 178885 serin 4. 60 2. 34 413691 AB023173 Hs. 75478 ATPase. UassVl type11B 4. 59 4. 36 448625 AW970786 Hs. 178470 hypothetical protein FU22662 4. 59 4. 00 436283 A1480319 Hs. 120058 ESTs 4. 59 3. 76 451710 AW867467 Hs. 278712 eukaryotic translation initiation factor 4. 59 3. 51 436086 Z43133 Hs. 9961 HomosapienscDNA : FLJ21954 fis, clone H 4. 59 3. 64 434697 AL133033 Hs. 4084 KIAA1025 protein 4. 58 5. 10 402294 Target Exon 4. 57 5. 47 424098 AF077374 Hs. 139322 small proline-rich protein 3 4. 57 5. 12 406648 AA563730 Hs. 277477 major histocompa6bility complex, class 4. 57 4. 66 428423 AU076517 Hs. 184276 501utecanierfamily9 (sodium/hydrogen 4. 57 4. 15 441566 AA604110 Hs. 151725 ESTs 4. 57 3. 21 400109 Eos Control 4. 56 4. 76 419740 AB037835 Hs. 92991 KIAA1414 protein 4. 56 3. 63 421481 AW391972 Hs. 104696 KIAA1324 protein 4. 55 7. 16 440266 AA088809 Hs. 19525 hypotheticalprotein FLJ22794 4. 55 4. 44 421979 AW062518 Hs. 233150 hypothetical protein MGC5560 4. 55 4. 36 408702 AW959893 Hs. 27099 hypothetical protein FW23293 similar to 4. 54 5. 78 418021 M15881 Hs. 1137 uromoduiinfuromucoid. Tamm-Horsfaiigiy 4. 54 4. 61 422068 Api807519 Hs. 104520 Homo sapiens CDNA FUl 3694 fis, clone PL 4. 54 4. 32 421986 AL137438 Hs. 110454 SEC15 (S. cerevisiae)-like 4. 54 2. 59 414798 A1286323 Hs. 97411 hypothetical protein MGC12335 4. 53 6. 18 410132 NM_003480 Hs. 300946 Microfibril-associated glycoprotein-2 4. 53 5. 87 449843 R85337 Hs. 24030 soiute earner famiiy 31 (copper transpo 4. 53 4. 87 424399 A1905687 Al905687 : IL-BT09S190199-019 BT095 Homo 4. 53 10. 61 452924 AW580939 Hs. 97199 complementcomponentC1qreceptor 4. 51 6. 07 454000 AA040620 Hs. 5672 hypothetical protein AF140225 4. 51 4. 59 404730 Target Exon 4. 51 4. 30 449943 AF104266 Hs. 24212 latrophilin 4. 51 3. 40 414217 Ai309298 Hs. 279898 Homo sapiens cDNA : FLJ23165 fis, clone L 4. 50 2. 97 435992 A1033259 Hs. 118317 Homo sapiens cDNA FLJ12088 fis, clone HE 4. 50 4. 77 421311 N71848 Hs. 283609 hypothetical protein PR02032 4. 50 3. 30 449785 A1225235 Hs. 288300 hypothetical protein FU23231 4. 49 5. 06 437611 AA897108 gb : amO8aO6. s1 Soares_NFL_T_GBC_S1 Homos 4. 49 4. 24 419612 A1498267 Hs. 110613 KIAA0421 protein 4. 49 4. 16 414496 W73853 ESTs 4. 49 3. 15 450306 AL080080 Hs. 24766 thioredoxin domain-containing 4. 48 3. 38 444895 A1674383 Hs. 22891 solute carder family 7 (cationic amino 4. 47 4. 45 432559 AW452948 Hs. 257631 ESTs 4. 47 5. 39 442554 AW467376 Hs. 129640 ESTs 4. 47 4. 00 421429 NM_014922 Hs. 104305 death effector filament-forming Ced-4-li 4. 46 4. 47 422313 AF045941 Hs. 115166 scieliin 4. 45 5. 07 435748 AA699756 Hs. 117335 ESTs 4. 45 3. 35 453283 AA694386 Hs. 290914 ESTs 4. 45 3. 28 441925 R83113 protein kinase C substrate 80K-H 4. 45 3. 28 440030 AA932693 EST 4. 45 3. 20 446515 AL048875 hypothetical protein DKFZp5661133 4. 44 3. 66 406707 S73840 Hs. 931 myosin, heavypolypep6de2 skeletalmu 4. 44 5. 90 432341 AL137662 Hs. 274401 Homo sapiens mRNA ; cDNA DKFZp434P086 (fr 4 44 3. 99 410453 AW749036 gb : RC2-BT0318-241199-011-MOBT0318 Homo 4. 44 3. 49 450196 AW956868 Hs. 24608 DKFZP564D177 protein 4. 43 4. 13 444147 AB002306 Hs. 10351 KIAA0308 protein 4. 43 3. 95 427809 M26380 Hs. 180878 lipoprotein lipase 4. 42 3. 88 428157 Api738719 Hs. 198427 hexokinase 2 4. 42 5. 46 413299 AA857487 Hs. 75275 ubiquitination factor E4A (homologous to 4. 42 3. 77 440245 AK001913 Hs. 7100 hypothetical protein 4. 42 3. 51 442379 NM 004613 Hs. 8265 transglutaminase 2 (C polypepfide, prote 4. 42 1. 79 408569 BE066047 Hs. 86412 chromosome 9 open reading frame 5 4. 42 3. 35 430361 A1033965 Hs. 239926 stemi-C4-methyl oxidase-like 4. 41 5. 78 414489 A1620677 Hs. 73105 ESTs 4. 41 5. 43 447731 AA373527 Hs. 19385 CGI-58 protein 4. 41 5. 28 443195 BE148235 Hs. 193063 HomosapienscDNAFW14Z01 fis cione NT 4. 41 4. 41 448503 BE243146 Hs. 21332 BTB (POZ) domain containing 1 4. 41 3. 68 432546 BE618778 Hs. 180638 hypothetical protein FU13081 4. 41 3. 55 445620 A1245225 Hs. 17441 ESTs 4. 41 3. 44 454065 BE394588 gb : 601311808F1 NlH_MGC_44Homosapiensc 4. 41 3. 43 418802 AB028989 Hs. 88500 mitogen-activated protein kinase 8 inter 4. 40 2. 04 431816 T87431 Hs. 190738 ESTs 4. 39 4. 26 429138 AB020657 Hs. 197298 NS1-binding protein 4. 39 4. 47 426643 AA857131 Hs. 171595 HIV TAT specific factor 1 4. 39 3. 09 448943 A1608810 Hs. 193288 ESTs 4. 39 2. 63 414002 NM006732 Hs. 75678 FBJ mudne osteosarcoma viral oncogene h 4. 37 19. 16 403593 Target Exon 4. 37 6. 35 408104 AW972927 Hs. 293968 ESTs 4. 31 5. 82 429624 AA458648 Hs. 99476 ESTs, Weakly similar to 1313184B alphal 4. 31 4. 14 429538 BE182592 Hs. 139322 small proline-rich protein 2A 4. 25 6. 61 414505 R45389 Hs. 23558 ESTs, Weakly similar to A48042 lysosomal 4. 18 5. 28 438533 A1440266 Hs. 170673 ESTs, WeaklysimilartoT24832hypothe6 4. 18 5. 81

426143 BE379836 proteasome (prosome, macropain) subunit 4. 15 5. 12 414527 BE241739 Hs. 76359 catalase 4. 14 5. 13 422287 F16365 Hs. 114346 cytochromecoxidasesubunitVllapolype 4. 13 8. 60 408199 AA132637 Hs. 15396 Homo sapiens, done IMAGE : 3948909, MARNA, 4. 12 5. 94 412477 AA150864 microsomal glutathione S-transferase 1 4. 10 10. 00 411558 AA102670 Hs. 70725 gamma-aminobutyric acid (GABA) A recepto 4. 09 5. 39 444252 R21135 Hs. 54985 ESTs 4. 07 6. 01 400295 W72838 Al905687 : 1L-BT095-190199-019 BT095 Homo 4. 06 13. 32 438746 A1885815 Hs. 184727 Human melanoma-associated antigen p97 (m 4. 06 7. 57 429856 AA971576 Hs. 225951 topoisomerase-related function protein 4 4. 05 6. 24 422168 AA586894 Hs. 112408 S100caicium-bindingproteinA7 (psorias 4. 01 4. 61 403710 C4000160 : gij12735793lref ; XP 011928. 11pr 4. 00 4. 06 406643 N77976 Hs. 347939 hemoglobin, alpha 2 3. 97 7. 22 436372 AW972301 Hs. 310286 ESTs 3. 96 5. 41 428340 AF261088 Hs. 154721 aconitaset. sotubie 3. 94 5. 33 424604 AW865388 Hs. 151076 KIM1243 protein 3. 91 7. 59 426653 AA530892 Hs. 171695 dual specificity phosphatase 1 3. 91 14. 81 410204 AJ243425 Hs. 326035 early growth response 1 3. 87 9. 96 448520 AB002367 Hs. 21355 doubiecor6n and CaM kinase-like 1 3. 87 5. 09 443021 AA368546 Hs. 8904 tgsuperfamiiy protein 3. 86 7. 65 430418 R98852 Hs. 36029 heart and neura) crest derivatives expra 3. 81 6. 19 447796 AW953622 Hs. 223025 RAB31 member RAS oncogene family 3. 76 5. 10 419407 AW410377 Hs. 41502 hypothetical protein FU21276 3. 76 5. 12 443725 AW245680 Hs. 9701 growth arrest and DNA-damage-inducible, 3. 75 5. 46 426281 AK000987 Hs. 169111 oxidation resistance 1 3. 74 5. 14 423973 AF038461 Hs. 136574 arachidonate 12-lipoxygenase, 12Rtype 3. 74 6. 30 445234 AW137636 Hs. 146059 ESTs 3. 72 5. 59 457411 AW085961 Hs. 130093 iroquois-dasshomeoboxprotein ! RX2 3. 71 4. 85 456063 NM006744 Hs. 76461 retinof-binding protein 4. interstitia) 3. 71 6. 72 413880 Al660842 Hs. 110915 interleukin 22 receptor 3. 71 4. 01 422640 M37984 Hs. 118845 troponin C, slow, 3. 71 9. 10 452241 AL050204 Hs. 28540 HomosapiensmRNA cDNADKFZp586F1223 (f 3. 70 3. 21 453560 AA348626 Hs. 5890 hypothetical protein FU23306 3. 69 5. 13 410197 Nom005518 Hs. 59889 3-hydroxy-3-methylglutaryl-CoenzymeAsy 3. 69 7. 69 413922 A1535895 Hs. 221024 ESTs 3. 68 4. 80 428698 AA852773 Hs. 334838 KIAA1866 protein 3. 64 5. 22 451951 AW082870 Hs. 210954 ESTs 3. 64 3. 69 452308 Ai167560 Hs. 61297 ESTs 3. 64 4. 35 441128 M570256 ESTs WeaklysimilartoT23273hypothe6 3. 63 2. 91 421978 AJ243662 Hs. 110196 NICE-1 protein 3. 61 6. 05 418533 NM 004533 Hs. 85937 myosin-binding protein C, fast-type 3. 61 6. 22 452413 AW082633 Hs. 215030 ESTs 3. 58 3. 03 453003 AA808466 Hs. 103395 hypothetical protein FU14146 3. 55 6. 39 408522 A1541214 Hs. 46320 Small proline-rich protein SPRK (human, 3. 54 10. 68 423503 M92843 Hs. 343586 zinc finger protein homologous to Zfp-36 3. 53 15. 11 419879 Z17805 Hs. 93564 Homer, neuronal immediate early gene, 2 3. 53 5. 29 428382 AF007132 Hs. 184019 Homo sapiens clone 23551 mRNA sequence 3. 51 4. 46 447165 AL042400 Hs. 75668 Homo sapiens, Similar to RIKEN cDNA 1700 3. 51 3. 67 418067 A1127958 Hs. 83393 cystatn E/M 3. 51 3. 74 420202 AL036557 Hs. 95910 putativelymphocyte GO/Gt switch gene 3. 50 14. 64 432543 AA552690 Hs. 152423 Homo sapiens cDNA : FLJ21274 fis, clone C 3. 50 2. 79 442321 AF207664 Hs. 8230 a disintegnn-like and metalloprotease (3. 43 7. 91 450860 AA021007 integrin, beta8 3. 47 5. 89 414665 AA160873 serum amyloid A1 3. 46 9. 22 413663 BE247585 Hs. 75462 BTGfamiiy member2 3. 46 5. 63 427408 AA583206 Hs. 2156 RAR-elatedorphanreceptorA 3. 45 3. 08 430171 AF086289 Hs. 234766 skin-specific protein 3. 45 4. 77 453655 AW960427 Hs. 342874 transforming growth factor, beta recepto 3. 42 8. 09 450607 AL050373 Hs. 25213 hypothetical protein 3. 41 6. 43 412596 AA161219 Hs. 799 diphtheria toxin receptor (heparin-bindi 3. 41 6. 10 427681 AB018263 Hs. 180338 tumor necrosis factor receptor superfami 3. 39 6. 59 440590 Al863446 Hs. 266308 mosaic serine protease 3. 34 3. 09 452669 AA216363 Hs. 262958 hypothetical protein DKFZp434B044 3. 31 10. 06 422101 AW404176 Hs. 111611 nbosomai protein L27 3. 30 3. 93 431986 Axa536130 Hs. 149018 Novel human gene mapping to chomosome 20 3. 30 3. 54 412649 NM 002206 Hs. 74369 integrin, alpha 7 3. 28 6. 89 423017 AW178761 Hs. 227948 serine (or cysteine) proteinase inhibito 3. 28 5. 44 425163 D10040 Hs. 154890 fatty-acid-Coenzyme A ligase, long-chain 3. 28 5. 93 412061 AA833763 Hs. 330211 ESTs 3. 27 5. 75 437592 NM_003851 Hs5710 cellularrepressorofE1A-stimulatedgen 3. 27 5. 83 452849 AF044924 Hs. 30792 hook2 protein 3. 26 5. 66 421462 AF016495 Hs. 104624 aquaporin9 3. 25 4. 98 422083 Nom-001141 Hs. 111256 7æhidonate1s-lipoxygenaseWsecondbp 3. 24 6. 56 444935 AA262449 Hs. 223569 ESTs 3. 24 5. 96 422057 A1205785 Hs. 30348 ESTs 3. 22 5. 72 410017 AW952426 Hs. 109438 Homosapiensclone24775mRNAsequence 3. 21 5. 26 407948 AW085161 Hs. 56279 ICEBERGcaspase-1 inhibitor 3. 21 4. 61 452089 T97294 Hs. 271492 ESTs, Weakly similar to PC4211 hepatocel 3. 19 4. 42 448249 AW855331 Hs. 337124 ESTs 3. 18 2. 97 430869 D10511 Hs. 37 acetyl-Coenzyme A acetyltransferase 1 (a 3. 17 5. 66 443623 AA345519 Hs. 9641 complement component t, q subcomponent, 3. 16 12. 00 452865 Api924046 Hs. 119567 ESTs Weakly similartoA47582 B-cellgr 3. 16 6. 03 452392 L20815 Hs. 507 comeodesmosin 3. 15 5. 70

410231 AA314163 Hs. 61153 proteasome (prosome, macropain) 26S subu 3. 15 5. 87 420309 AW043637 Hs. 21766 ESTs. Weakly similar to ALU5_HUMAN ALU S 3. 15 4. 98 406791 Api220684 Hs. 347939 hemoglobin, alpha 2 3. 13 17. 37 419648 T73661 Hs. 91877 thyroid hormone responsive SPOT14 (rat) 3. 12 4. 63 421485 AA243499 Hs. 104800 hypothetical protein FLJ10134 3. 12 3. 02 432375 BE536069 Hs. 2962 S100calcium-binding protein P 3. 12 8. 51 417713 D42047 Hs. 82432 KIAA0089 protein 3, 12 5. 82 446948 BE409053 Hs. 299629 peroxisomal long-chain acyl-coAthioeste 3. 11 6. 51 444195 AB002351 Hs. 10587 KIAA0353 protein 3. 11 5. 44 415704 NM_001677 Hs. 78629 ATPase, Na ? transporting, beta 1 polypep 3. 11 6. 61 401905 ENSP00000252232' : Sterol regulatory eleme 3. 10 3. 52 443071 AL080021 Hs. 8986 complement component 1, q subcomponent 3. 10 5. 10 427095 AA316080 Hs. 173554 ubiquinol-cytochromecredudaseazrepr 3. 10 5. 39 413835 Al272727 Hs. 249163 fatty acid hydroxylase 3. 08 5. 56 448106 A1800470 Hs. 171941 ESTs 3. 07 5. 19 432908 Al861896 ESTs 3. 07 3. 47 422158 L10343 Hs. 112341 pnoteaseinhibitor3, skin-denved (SKAL 3. 07 7. 48 429506 D49835 Hs. 171942 ras responsive element binding protein 1 3. 05 3. 97 424998 U58515 Hs. 154138 chitinase 3like 2 3. 02 6. 75 419358 T78763 Hs. 90063 neurocalcin delta 3. 00 7. 68 414541 BE293116 Hs. 76392 aldehyde dehydrogenase t family, member 2. 99 5. 44 426402 BE387327 Hs. 80475 polymerase (RNA) II (DNA directed) polyp 2. 99 6. 84 450472 A1190071 Hs. 55278 ESTs 2. 98 5 06 421335 X99977 Hs. 103505 ARS component B 2. 97 9. 31 431316 AA502663 Hs. 145037 ESTs 2. 96 4. 30 420996 AK001927 Hs. 100895 hypothetical protein FW10462 2. 96 2. 97 451176 AA046457 Hs. 60677 ESTs 2. 95 6. 59 444204 A1129194 Hs. 143040 ESTs 2. 93 3. 92 436723 AW975895 Hs. 307486 ESTs 2. 93 6. 64 436664 AW197887 Hs. 253353 ESTs 293 3. 82 406962 M13485 gb : Human metallothionein I-8 gene, exon 2. 93 3. 10 453092 X64838 Hs. 31638 resfin (Reed-Steinberg celt-expressed in 2. 93 5. 35 444734 NM 001360 Hs. 11806 7-dehydrocholesterolreductase 2. 91 9. 84 430310 U60115 Hs. 239069 four and a half LIM domains 1 2. 91 7. 02 420876 AA918425 Hs. 177744 ESTs 2. 91 5. 41 426050 AF017307 Hs. 166096 E74-iikefactor3 (etsdomaintranscript 2. 91 5. 64 428232 BE272452 Hs. 183109 monoamineoxidaseA 2. 90 9. 54 413796 AW408094 Hs. 75545 interleukin 4 receptor 2. 89 5. 37 413884 A1668892 Hs. 239758 hypothetical protein FU 12389 similar to 2. 88 5. 34 411372 Api147861 Hs. 213289 low density lipoprotein receptor (famili 2. 86 6. 31 428500 A1815395 Hs. 184641 fatty acid desaturase 2 2. 86 3. 93 444135 AK000374 Hs. 10346 hypothetical protein FLJ20154 2. 86 6. 05 452689 F33868 Hs. 284176 transferrin 2. 85 6. 11 403108 ENSP00000241415' : Hypothe6cal 67. 7 kDa p 2. 85 3. 17 434433 AW629759 gb : hh70eO5. y1 NCI_CGAP_GU1 Homo sapiens 2. 84 3. 35 434952 T10269 Hs. 4285 HomosapienscDNAFW22505fis, cloneH 2. 83 4. 05 420544 AA677577 Hs. 98732 Homo sapiens Chromosome 16 BAC clone CIT 2. 83 3. 57 406922 S70284 Hs. 119597 gb : stearoyl-CoAdesaturaselhuman, adipo 2. 82 3. 80 437470 AL390147 Hs. 134742 hypothetical protein DKFZp547D065 2. 82 6. 40 429807 AK002138 Hs. 306227 HomosapienscDNAFLJ11276fis, clonePL 2. 82 2. 97 425180 U00115 Hs. 155024 B-cellCLLymphoma6 (zincfingerpnote 2. 81 5. 15 415409 AW993701 NS1-associated protein 1 2. 80 6. 16 433848 AF095719 Hs. 93764 carboxypepGdase A4 2. 80 2. 88 425750 AL050276 Hs. 42400 zinc finger protein 288 2. 79 5. 99 433638 AW872507 Hs. 3462 cytochrome c oxidase subunit Vllc 2. 78 5. 25 429128 AA446869 Hs. 119316 ESTs 2. 78 4. 17 446292 AF081497 Hs. 279682 Rh type C glycoprotein 2. 77 7. 37 430420 AW140027 Hs. 26373 Homo sapiens cDNA : FU23449 fis, clone H 2. 76 6. 09 419923 AW081455 Hs. 120219 ESTs 2. 76 4. 31 407555 Z48511 gb : H. sapiensXGmRNA (clonePEP11). 2. 76 4. 12 425240 AA306495 Hs. 1869 phosphoglucomutase 1 2. 74 5 92 459317 BRCAlb Eos Control 2. 74 19. 85 425819 N92165 Hs. 93231 ESTs 2. 74 5. 72 408839 AW277084 gb : xp61h09. x1NCiCGAPOv39 Homo sapiens 2. 73 3. 93 418253 AA215539 Hs. 283643 HomosapienscDNAFLJ11606fis, cloneHE 2. 72 5. 94 409453 A1885516 Hs. 95612 ESTs 2. 72 6. 51 406625 Y13647 Hs. 119597 stearoyl-CoA desaturase (delta-9-desatur 2. 72 3. 80 420074 AA253425 Hs. 190074 ESTs 2. 71 4. 04 429547 AW009166 Hs. 99376 FGENESH predicted novel secreted protein 2. 71 2. 84 444026 AA205759 Hs. 10119 hypothetical protein FU14957 2. 71 6. 17 407112 AA070801 Hs. 51615 ESTs, Weakly similar to ALU7 HUMAN ALU S 2. 70 5. 23 429615 AF258627 Hs. 211562 ATP-bindingcassette, sub-familyA (ABC1 2. 69 5. 33 419098 AA234041 Hs. 87271 ESTs 2. 69 3. 22 424206 NM003734 Hs. 198241 amine oxidase, copper containing 3 (vasc 2. 69 6. 64 443102 A1247472 Hs. 132965 ESTs 2. 68 5. 85 411939 A1365585 Hs. 146246 ESTs 2. 68 5. 38 453201 Al432195 Hs. 135098 ESTs 2. 68 3. 69 420231 R06866 Hs. 19813 ESTs 2. 67 4. 70 404996 Target Exon 2. 67 4. 97 452955 AW390282 Hs. 31130 transmembrane 7 superfamily member 2 2. 66 6. 36 447205 BE617015 Hs. 11006 ESTs. Moderately similar to T17372 plasm 2. 65 15. 65 417365 D50683 Hs. 82028 transforming growth factor, beta recepto 2. 65 7. 74 444169 AV648170 Hs. 58756 ESTs 2. 64 3. 40

431247 AL021578 Hs. 278489 matri) in4 2. 64 3. 35 423960 AA164516 Hs. 136309 SH3containing protein SH3GLB1 2. 63 5. 12 432093 H28383 gb : yl52c03. r1 Soares breast 3NbHBst Homo 2. 63 4. 08 408669 Al493591 Hs. 78146 platelet/endothelial cell adhesion molec 2. 61 6. 44 440924 AF151872 Hs. 7527 small fragment nuclease 2. 59 6. 37 416232 AW502678 Hs. 79090 exportin 1 (CRM1, yeast, homolog) Z59 6. 46 425320 U29344 Hs. 83190 fatty acid synthase 2. 59 3. 93 402315 NM_003430 : Homo sapiens zinc finger prote 2. 58 6. 09 449539 W80363 Hs. 58446 ESTs 2. 58 4. 05 418271 NM 000919 Hs. 83920 peptidyiglycinealpha-amida6ngmonooxyg 2. 58 5. 61 449967 R40978 Hs. 271498 ESTS, Moderately similar to ALU I1UMAN A 2. 58 3. 54 438752 AW238673 Hs. 146038 ESTs 2. 58 5. 24 424675 NM_005512 Hs. 151641 glycoprotein A repetitions predominant 2. 57 5. 16 438763 AI583207 Hs. 99029 CCAAT/enhancer binding protein (GBP), 2. 57 6. 45 413630 AL036883 Hs-75450 delta sleep inducing peptde, immunoreac 2. 56 6. 38 424834 AK001432 Hs. 153408 Homo sapiens cDNA FtJ10570 fis, cbne NT 2. 56 2. 90 427666 A1791495 Hs. 180142 calmodulin-like skin protein (CLSP) 2. 56 2. 67 426403 NM 000361 Hs. 2030 thrombomodulin 2. 56 5. 19 432906 BE265489 Hs. 3123 lethal giant larvae (Drosophila) homolog 2. 55 5. 62 420924 R01026 Hs. 245321 ESTs 2. 55 3. 22 427527 A1809057 Hs. 153261 immunoglobulin heavy constant mu 2. 55 5. 45 407083 Z48511 H. sapiens XG mRNA (clone PEP11} 2. 55 4. 50 445437 A1224165 Hs. 148725 ESTs 2. 54 4. 72 425097 NM_014247 PDZdomåncontaningguaninenucleo6de 2. 54 5. 28 420105 AW015571 Hs. 32244 ESTs, WeakysimilartoFMOD_HUMANFIBRO 2. 53 6. 55 429554 NM012275 Hs. 207224 interieuhn 1, delta 2. 53 2. 84 408896 A1610447 Hs. 48778 niban protein 2. 53 7. 08 409169 F00991 Hs. 50889 (clone PWHLC2-24) myosin light chain 2 2. 52 8. 68 420235 AA256756 Hs. 31178 ESTs 2. 51 4. 21 436314 A1983409 ESTs 2. 51 3. 11 440602 A1743491 Hs. 292692 ESTs 2. 50 2. 71 444946 AW139205 Hs. 156457 hypotheticalprotein FLJ22408 2. 48 2. 86 430235 BE268048 Hs. 236494 RAB10, member RAS oncogene family 2. 48 5. 37 423929 M69136 Hs. 135626 chymase 1, mast cell 2. 48 3. 21 426689 BE245550 Hs. 171825 basichelix-loop-helixdomaincontaining 2. 48 7. 88 421811 AA022550 Hs. 108548 PABP-interæ6ng protein 2 2. 48 5. 28 414420 AA043424 Hs. 76095 immediåe eariy esponse 3 2. 47 8. 33 420693 NM_001972 Hs. 99863 elasiase 2, neuuophil 2. 47 2. 78 420139 NM_005357 Hs-95351 lipase, homione-sensifive 2. 46 10. 12 447179 AW015633 Hs. 157299 ESTs 2. 46 3. 45 451687 AL041260 Hs. 26837 Homo sapiens mRNA : cDNADKFZp586K1123 (f 2. 46 5. 47 420322 AB014555 Hs. 96731 huntingtin interacting protein-1-related 2. 45 6. 18 421064 A1245432 Hs. 101382 tumor necrosis factor, alpha-induced pro 2. 45 5. 75 421818 AW992976 Hs. 50098 NM_002489 : HomosapiensNADHdehydroXqenas 2. 45 6. 73 412524 AA417813 Hs. 44208 hypothetical protein FLJ23153 2. 44 10. 55 439639 AA370045 Hs. 6607 AXIN1 up-regulated 2. 44 5. 22 436009 H57130 Hs. 120925 ESTs 2. 44 2. 94 414814 D14697 Hs. 77393 famesyl diphosphate synthase (farnesyl 2. 43 5. 17 434060 AA744902 Hs. 197922 hypothetical protein PR01489 2. 43 5. 56 425335 BE394327 Hs. 296267 follistatin-like 1 2. 43 10. 52 406997 U07807 metallothionein IV 2. 42 4. 35 431545 AF095703 Hs. 8i10 L-3-hydroxyacyl-Coenzyme A dehydrogenase 2. 42 6. 72 417029 AW952192 Hs-273385 guanine nucleofide binding protein (G pr 2. 41 5. 22 412825 AW167439 Hs. 190651 Homo sapiens cDNA FW 13625 fis, clone PL 2. 41 5. 56 445462 AA378776 Hs. 288649 hypothetical protein MGC3077 2. 41 5. 24 448954 AB014564 Hs. 22616 KIAA0664 protein 2. 40 5. 31 447218 BE617762 Hs. 10748 hypothe6calprotein DKFZp434B195 2. 40 5. 24 423810 AL132665 Hs. 132955 BCWædenovinus E1B 19kD-interæ6ng pro 2. 39 5. 55 450440 AB024334 Hs. 25001 tyrosine 3-monooxygenase/tryptophan 5-mo 2. 39 7. 63 430356 N87990 Hs. 239870 Homo sapiens mRNA ; cDNADKFZp564H0764 (f 2. 38 5. 99 418355 L42563 Hs. 1165 ATPase, H ? transporting, nongaswe, alp 2. 38 3. 84 416273 AW575691 Hs. 79123 KIAA0084 protein 2. 38 5. 22 427272 NM 001096 Hs. 174140 ATP citrate lyase 2. 38 5. 41 437186 AA338305 Hs. 5472 hypothetical protein FLJ20173 2. 35 5. 13 443679 AK001810 Hs. 9670 hypotheticalprotein FLJ10948 2. 33 5. 81 431179 A1338644 Hs. 195432 aldehyde dehydrogenase 2family (mitocho 2. 33 7. 89 418400 BE243026 Hs. 301989 KIAA0246 protein 2. 33 5. 36 456876 AL044870 Hs. 208780 ESTs, Weakly similar to T29647 hypotheti 2. 32 3. 27 407082 Z47055 gb : Human partial cDNA sequence, famesyl 2. 31 4. 65 426508 W23184 Hs. 170171 glutamate-ammonia ligase (glutamine synt 2. 31 9. 37 408536 AW381532 Hs. 135188 ESTs 2. 31 2. 60 410552 X66945 Hs. 748 fibroblast growth factor receptor 1 (fms 2. 30 5. 94 437201 F29279 Hs. 171625 hypotheticalprotein MGC14697 2. 30 5. 75 417314 N68168 gb : zai icO1. s1 Soares fetal liver spleen 2. 30 3. 12 433738 AI684802 ESTs 2. 30 3. 91 410531 AW752953 gb : qVO-CT0224-261099-035-gO2 CT0224 Homo 2. 29 3. 61 422491 AA338548 Hs. 117546 neuronatin 2. 29 5. 66 434411 AA632649 Hs. 201372 ESTs 2, 28 4. 40 451926 AW134519 Hs. 96125 Homo sapiens, Similar to clone FLB3816, 2. 28 5. 14 401131 NM_001651-: HomosapiensaquaponnS (AOP 2. 27 5. 62 401205 Target Exon 2. 27 2. 98 422109 S73265 Hs, 1473 gastrin-reteasingpeptide 2. 26 3. 94 456646 AJ243662 Hs. 110196 NICE-1 protein 2. 26 2. 52

443049 A1028613 Hs. 132343 ESTs 2. 25 3. 13 440160 BE560269 Hs. 7010 NPD002 protein 2. 25 4. 93 438367 N79688 Hs. 204354 rashomotog gene family, member B 2. 25 9. 58 442987 AA075975 Homo sapiens clone TCCCIA00427 mRNA sequ 2. 24 6. 19 421545 AA292810 Hs. 90034 hypothetical protein FLJ21916 2. 24 2. 58 447150 A1439011 Hs. 86386 myeloid cell leukemia sequence 1 (BCL2-r 2. 23 9. 03 450014 N41322 Hs. 18441 ESTs 2. 23 4. 50 426611 BE178050 Hs. 171271 catenin (cadhedn-associated protein), b 2. 22 5. 64 434039 L32977 Hs. 3712 ubiquinol-cytochromecreductase, Rieske 2. 22 5. 57 427569 BE299197 Hs. 179665 cyclin-dependent kinase inhibitor 1A (p2 2. 22 5. 10 444637 T19101 Hs. 11494 fibulin 5 2. 22 6. 43 406710 Api708347 Hs. 184014 ribosome protein L31 2. 21 9. 10 424909 S78187 Hs. 153752 cell division cycle 25B 2. 20 6. 13 407228 M25079 Hs. 155376 hemoglobin, beta 2. 20 11. 34 450612 AL359946 Hs. 14779 acetyl-CoA synthetase 2. 20 7. 03 458568 AI769067 Hs. 127824 ESTs, Weakly similar to T28770 hypotheti 2. 20 5. 68 407370 AA682384 Hs. 182084 ESTs 2. 20 7. 00 438942 AW875398 Hs. 6451 PR00659 protein 2. 19 6. 09 400228 NM021724' : Homo sapiens nudear receptor 2. 19 6. 95 410185 BE294068 Hs. 737 immediate eafly protein 2. 18 11. 72 428150 AW950547 Hs. 70312 cytochromecoxidasesubunitVllapolype 2. 17 7. 05 400307 AF005081 Homo sapiens skin-specific protein (xp32 2. 17 6. 41 424425 AB031480 Hs. 146824 SPR1 protein 2. 17 3. 68 414459 Y11525 Hs. 76171 CCMT/enhancerbindinagprotein (UEBP), 2. 17 3. 11 400082 Eos Control 2. 16 8. 40 434702 AL039734 Hs. 4099 nardilysin (N-arginine dibasic convertas 2. 16 6. 83 439651 AF086480 Hs. 56255 ESTs 2. 16 3. 72 431838 A1097229 Hs. 217484 ESTs, Weakly similar to ALUt HUMAN ALU S 2. 15 3. 34 420225 AW243046 Hs. 282076 Homo sapiens mRNA for KIAA1650 protein, 2. 14 6. 20 428848 NM 000230 Hs. 194236 lepUn (murineobesityhomoloq) 2. 14 3. 42 415213 NM 002933 Hs. 78224 dbonuclease, RNaseAfamily, 1 (pancrea 2. 14 9. 81 434454 AF217798 Hs. 3850 LIS1-interacting protein NUDEL ; endoolig 2. 14 6. 75 452467 AW500815 ESTs 2. 13 4. 66 418226 AA424202 Hs. 83834 cytochrome b-5 2. 13 5. 41 414815 AW292140 Hs. 130286 ESTs 2. 12 4. 14 430967 H16791 Hs. 100895 ESTs 2. 12 4. 14 426102 AF200496 Hs. 166371 inteneukinl. zeta 2. 12 3. 77 410223 S73775 Hs. 60708 calsequestrin1 (fast-twitch, skeletal m 2. 11 5. 30 439518 W76326 gb : zd60dO4. r1 Soares_fetal_heart_NbHH19W 2. 11 4. 01 427228 AA115770 Hs. 174051 smail nuclear ribonucleoprotein 70kD pol 2. 10 5. 13 436961 AW375974 Hs. 156704 ESTs 2. 10 3. 33 417139 M69043 Hs. 81328 nuclear factor of kappa light polypeptid 2. 10 8. 13 445831 NM_006055 Hs. 13351 LanC (bætenålan6bio6csynthetasec 2. 08 5. 42 431593 NM 002108 Hs. 276590 ESTs 2. 08 4. 43 423887 AL080207 Hs. 134585 DKFZP434G232 protein 2. 08 3. 92 424389 AA339786 lymphocyte-specific protein 1 2. 07 5. 52 407394 AF005081 gb : Homo sapiens skin-specific protein (x 2. 06 5. 93 400198 Eos Control 2. 05 10. 48 426335 A1054347 Hs. 2017 ribosome protein L38 2. 04 5. 57 443652 A1080692 Hs. 134229 ESTs, Weakly similar to 154401 hypertens 2. 04 3. 36 448804 AW512213 Hs. 342849 ADP-ribosylation factor-like 5 2. 02 3. 32 443932 AW888222 Hs. 9973 tensin 2. 02 9. 28 421324 BE257515 Hs. 103503 deoxyribonuclease I-like 2 2. 02 5. 71 426406 Api742501 Hs. 169756 complement component 1, s subcomponent 2. 01 5. 49 410669 AW805749 superoxide dismutase 2, mitochondrial 2. 01 3. 05 446193 A1279390 Hs. 144658 ESTs, Weakly similar to T17257 hypothefi 2. 01 2. 77 400078 Eos Control 2. 00 11. 41 456267 A1127958 Hs. 83393 cystatin EIM 1. 99 3. 59 413125 BE244589 Hs. 75207 glyoxalase 1 1. 98 6. 70 415433 W70067 Hs. 58066 ESTs 1. 98 5. 59 434699 AA643687 Hs. 149425 HomosapienscDNAFW11980fis, cloneHE 1. 98 3. 52 417553 L09190 trichohyalin 1. 98 3. 39 403105 Target Exon 1. 98 5. 05 414081 AW969976 matrix Gla protein 1. 97 8. 74 422639 A1929377 Hs. 173724 creatine kinase, brain 1. 97 5. 51 452208 AA024792 Hs. 31895 hypothetical protein MGC4093 1. 97 5. 67 436106 A1050715 Hs. 2331 E2Ftranscrip60nfætorS, p130-binding 1. 97 5. 75 439265 AL134430 Hs. 6906 Homo sapiens cDNA : FW23197fis, cloneR 1. 96 5. 09 430037 BE409649 Hs. 227789 mitogen-æ6vated protein kinase-activat 1. 96 5. 49 440054 AW661947 Hs. 6891 splicing factor, arginine/serine-rich 6 1. 95 5. 95 417088 M54915 Hs. 81170 pim-1 oncogene 1. 95 8. 19 429451 BE409861 Hs. 202833 heme oxygenase (decycling) 1 1. 95 5. 19 415274 AF001548 Hs. 78344 myosin, heavy potypeptide 11. smooth mus 1. 95 6. 78 452472 AW957300 Hs. 294142 ESTs, Weakly similar to C55663 oligodend 1. 94 5. 98 414860 BE255593 Hs. 77502 methionine adenosyltransferase 11, alpha 1. 94 5. 13 437220 AL117542 Hs. 334305 GS1999full 1. 94 3. 42 450461 BE408081 Hs. 46736 hypothetical protein FU23476 1. 94 5. 66 424924 AL039103 Hs. 153834 pumilio (Drosophila) homolog 1 1. 93 5. 28 413945 NM_000591 Hs. 75627 CD14 antigen 1. 93 5. 38 428193 NM_004235 Kruppel-like factor 4 (gut) 1. 93 5. 75 415988 BE407713 Hs. 78943 bleomycin hydrolase 1. 92 4. 65 425783 A1026740 Hs. 1948 ribosome protein S21 1. 92 9. 79 431476 BE612705 Hs. 256697 histidinetnadnudeotide-bindingprote 1. 91 7. 00

456653 A1807519 Hs. 104520 Homo sapiens cDNA FU13694 fis, clone PL 1. 91 3. 41 401846 NM000988' : Homo sapiens ribosomal protei 1. 91 5. 62 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin 1. 90 4. 00 400199 Eos Control 1. 89 15. 74 429367 AB007867 Hs. 278311 plexin 81 1. 88 5. 58 400083 Eos Control 1. 88 9. 07 433465 AV657778 Hs. 3314 selenoprotein P, piasma, 1 1. 88 5. 16 400079 Eos Control 1. 87 8. 57 411807 AK000290 Hs. 44033 dipeptidylpeptidase8 1. 86 5. 19 409178 BE393948 Hs. 50915 kallikrein5 1. 85 2. 75 422624 BE616678 Hs. 76152 KDEL (Lys-Asp-Giu-Leu) endoplasmic e6c 1. 85 5. 33 443121 Z19267 Hs. 9006 VAMP (vesicle-associated membrane protei 1. 85 6. 01 451092 A ! 207256 Hs. 13766 Homo sapiens mRNA for FU00074 protein. 1. 84 2. 82 430572 U33114 Hs. 245188 6ssueinhibitorofmetalloproteinase3 1. 83 5. 10 426812 AF105365 Hs. 172613 solutecarierfamily12 (potassium/dhlo 1. 83 6. 48 439927 AA854650 Hs. 124597 ESTs 1. 82 3. 63 415089 N25117 Hs. 299465 ribosomal protein S26 1. 82 6. 69 406400 kallikrein 8 (neuropsin/ovasin) (KLK8) 1. 82 2. 95 406467 Target Exon 1. 79 2. 65 426672 AW270555 Hs. 171774 hypothetical protein 1. 79 5. 24 414088 AW797956 Hs. 75748 proteasome (prosome, macropain) subunit, 1. 78 6. 02 433271 BE621697 Hs. 14317 nucleolar protein family A, member 3 (H/1. 78 5. 92 429307 AU076592 Hs. 198951 jun B proto-oncogene 1. 77 5. 44 433640 AW390125 Hs. 240443 Homo sapiens cDNA : FU23538 fis, done L 1. 77 5. 79 425503 W92517 Hs. 158203 actin binding LIM protein 1 1. 77 9. 27 429191 AF065215 Hs. 198161 phospholipase A2, group IVB (cytosolic) 1. 77 5. 44 425875 AU077333 Hs. 160483 erythrocyte membrane protein band 7. 2 (s 1. 77 6. 97 431021 A1869664 thiosulfate suifurtransferase (rhodanese 1. 77 5. 23 432891 AF161483 Hs. 279761 HSPC134 protein 1. 75 5. 73 432872 A1908984 Hs. 279623 selenoprotein X, 1 1. 75 5. 72 451335 AB023192 Hs. 26285 imidazoline receptor candidate 1. 75 6. 87 428975 NM004672 Hs. 194694 mitogen-activated protein kinase kinase 1. 74 3. 01 417824 AA084798 Hs. 82646 DnaJ (Hsp40) homolog, subfamily B, membe 1. 74 5. 75 439908 Al168031 Hs. 155507 ESTs 1. 74 2. 63 427349 AA360154 Hs. 177415 Finkel-Biskis-Reillymurinesarcomaviru 1. 74 6. 80 445919 T53519 Hs. 334692 hypothetical protein MGC14141 1. 74 5. 65 427391 W60675 hypothetical protein FLJ10350 1. 73 6. 13 425299 AW505214 Hs. 155560 catnexin 1. 73 5. 88 430449 AA352723 Hs. 241471 RNB6 1. 72 5. 14 456766 R87310 Hs. 7740 oxysterol binding protein-like 1 1. 71 4. 35 407694 U77594 Hs. 37682 retinoic acid receptor responder (tazaro 1. 71 6. 16 412374 X01388 Hs. 73849 apolipopnDtein C-lil 1. 70 5. 18 417483 BE549343 Hs. 82208 acyl-Coenzyme A dehydrogenase, very long 1. 70 7. 46 410584 AB011112 Hs. 64742 KIAA0540protein 1. 69 6. 19 431882 NM001426 Hs. 271977 engrailed homolog 1 1. 68 2. 63 441379 AW175787 Hs. 334841 selenium binding protein 1 1. 67 7. 42 422115 Al878953 Hs. 111811 microsomal glutathione S-transferase 3 1. 67 6. 93 406742 A1468091 Hs. 279860 tumor protein, translationally-controlle 1. 66 6. 26 432191 AA043193 Hs. 273186 hypothetical protein, clone Telethon (Ita 1. 65 5. 83 452363 AI582743 Hs. 94953 Homo sapiens. Similar to complement comp 1. 65 7. 54 446623 AF279865 Hs. 15711 kinesin family member 13B 1. 65 5. 36 406712 M31212 Hs. 77385 myosin, light polypeptide 6, alkali, smo 1. 65 12. 30 400202 NM 002795 : Homo sapiens proteasome (pros 1. 64 5. 70 401429 C14001067 : gil4126465ldbjlBM36581. 1l (AB 1. 64 3. 82 415166 NM003652 Hs. 78068 carboxypep6dase Z 1. 62 5. 95 410169 Api373741 Hs. 59384 hypothetical protein MGC3047 1. 61 6. 60 406713 U02629 Hs. 77385 myosin, light polypeptide 6, alkali, smo 1. 60 11. 13 453027 Al879341 Hs. 539 ribosome protein S29 1. 60 10. 97 416955 AW889150 Hs. 80595 NM_004552 : Homo sapiens NADH dehydrogena 1. 60 5. 90 439053 BE244588 Hs. 6456 chaperonin containing TCP1, subunit 2 (b 1. 57 5. 60 400201 NM_006156-: Homosapiensneuraprecursor 1. 57 5. 32 407049 X72632 NM_021724* : Homo sapiens nuclear receptor 1. 57 5. 42 430775 A1879186 Hs. 250895 ribosomal protein L34 1. 57 7. 09 427380 NM 005534 Hs. 177559 interferon gamma receptor 2 (interferon 1. 56 5. 37 407143 C14076 Hs. 332329 EST 1. 56 6. 54 436127 W94824 Hs. 11565 RIKEN cDNA 2010100012 gene 1. 56 6. 35 413659 BE155647 gb : PM2-HT0353-130100-002-e09HT0353Homo 1. 55 5. 96 445624 AW140103 Hs. 78880 ilvb (bacterial acetolactate synthaseyl 1. 55 4. 09 435044 NM002802 Hs. 4745 proteasome (prosome, macropain) 26S subu 1. 55 5. 71 410397 AF217517 Hs. 63042 DKFZp564J157protein 1. 54 5. 14 429071 AW794126 Hs. 195453 ribosomal protein S27 (metallopansfimuli 1. 54 8. 70 412915 AW087727 Hs. 74823 NM004541 : Homo sapiens NADH dehydrogenas 1. 54 6. 57 446429 Api681807 Hs. 201391 ESTs 1. 53 2. 87 414551 Al815639 Hs. 76394 enoyl Coenzyme A hydratase, short chain, 1. 53 6. 07 406801 AW242054 Hs. 190813 ribosome protein L9 1. 52 5. 63 437895 AB014568 Hs. 5898 KIAA0668 protein 1. 51 5. 74 413929 BE501689 Hs. 75617 collagen, type IV, alpha 2 1. 51 6. 40 425456 T70445 Hs. 157850 ribosomal protein L9 1. 51 7. 08 409635 Z37166 Hs. 55296 HLA-B associated transcript-1 1. 50 5. 26 404467 Target Exon 1. 50 5. 82 406743 AA911568 Hs. 279860 tumorprotein. transiationaiiy-controlie 1. 50 5. 25 454098 W27953 Hs. 292911 Plakophilin 1. 48 3. 14 429205 A1492393 Hs. 198248 UDP-Gal : betaGIcNAc beta 1, 4- galactosylt 1. 48 6. 24

413825 BE299181 Hs. 75564 CD151 antigen 1. 47 5. 64 421143 AB024536 Hs. 102171 immunoglobulin superfamily containing le 1. 45 6. 19 440254 Al879332 Hs. 7101 anaphase-promoting complex subunit 5 1. 45 5. 50 406711 N25514 Hs. 77385 myosin, light polypeptide 6, aikali, smo 1. 42 11. 24 423513 AF035960 Hs. 129719 transglutaffinase 5 1. 42 3. 18 406896 D00159 gb : Homo sapiens gene for pancreatic elas 1. 41 6. 92 433453 BE548307 Hs. 3297 ribosome protein S27a 1. 40 5. 38 406800 AA505535 gb : nh84h10. s1 NCI CGAP_Brl. i Homo sapien 1. 37 5. 51 421748 NM_014718 Hs. 107809 KIAA0726 gene product 1. 37 5. 46 424372 AW952803 Hs. 21732 Homo sapiens cDNA FU 11780 fis, clone HE 1. 36 4. 06 408250 R92918 Hs. 19597 KIAA1694 protein 1. 27 2. 74 431931 AB035302 Hs. 272212 cadherin 9, type 2 (T1-cadherin) 1. 15 2. 65 406587 C15000544' : gi5454148petNP_006368. 1 U 1. 06 3. 11 409574 AW419080 Hs. 250645 ESTs 1. 00 3. 60 404175 Target Exon 1. 00 3. 08 452640 AA027115 Hs. 100206 ESTs, Weakly similar to A53856 aryl-acyl 1. 00 2. 82 443564 Api921685 Hs. 199713 ESTs 1. 00 2. 51 TABLE 65B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 407328 534268_1 A1673735 AA978066 427890 13739881 AA417099AA435761AA972917At660387 444207 9172_3 BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA169357 BE932464 AA514889 AW819039 AW819083 BE843048 Al432496 Al470335 Al247243 BG533994 AA513783 A1887309 AA528036 AW972006 AW873028 A1924914 Al818810 AW152378 AW084946 AI521413 AI669583 BE932521 Ai581370 BE180238 AW089750 AW771461 AW089714 A1590949 A1819148 AA731056 BF815234 BF911506 AA235803 AA485373 A1735658 AW393133 AW073080 A1707637 BF353320 BE843111 AW819036 AW393135 BG697291 AV648670 AV654332 AV687530 BG566964AI807430 Al676072 M837010 Al452482 Al625817 AW241750 BE048616 AI290928 AI680714 AA485530 BE175687 AV648513 AW130312 A1000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345 AI244948 AA602956 AA483492 AA918178 AW802049 BG675859 AV658871 BG678060 Al565004 AW819026 BE843092 AV686437 AV723049 BG616948 Al911647 Al743490 Al091096 BE857251 AI962074 AA040027 AW769317 AA343477 AA640112 BF876213 R82948 H26425 H82876 BE843095 BE843140 BG536641 BG617830 AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996 A1749532 BE768614 BE857252 BE932516 BE768573 AV657993 AV657777 AV752631 BE774974 T55847 BF095761 Bof911511 BE710793 BE180119 BG617338 H45942 T55897 AV657718 BG563497 407102 71n 2 AW945170 BF930905 F33652 BG057818 AI368018 AI421485 AI300352 AI378525 AI264177 AI276281 AI245302 AI281050 AI190036 AW451438 AW242903 AA910870 F22289 F19647 F22375 AW473816 BF445785 AA774528 F33447 C01077 AW772227 F17759 H42812 R09701 AA349096 R48772 H42892 H42537 R47898 N28263 H25721 F32386 H43971 R48205 F21390 H45809 AA007629 R47897 R83734 H45844 AW983653 H43970 H42536 H24495 R48875 H42961 H22079 R86018 437596 2875 1 BC022398 AV743635 AW976922 AW152652 AA910013 AA834629 BG536317 AW849807 AV713062 Api684337 BE044081 AA761490 440116 454673-1 R69942 BG655457 BF111453 AI149320 N23160 AI446431 AI758316 AV741781 BI791950 BM055014 AI798851 AA865357 AI417230 N67277 T55592 T52179 443072 449629 1 AV734838 A1937532 A1032318 AW749500 AA091720 442679 31783_3 BG621493 81056706 BG496376 R53718 W65356 R79357 BG434247 AA357769 AW978686 BG573200 BF132113 BF086709 AA366938 D79234 BG494628 AA156754 BG434311 AW978683 AW273417 BM054662 Al799886 Al433351 Al160798 Al433742 BF056186 A1281606 AWOI 5046 A1439585 Al245530 Al078267 M807170 M837395 W61252 AA831085 AA287371 AW768354 AA890606 AI302539 AI708575 AI673031 AI242260 AW514069 AA283958 AA825452 AI371234 AA425696 AA453422 AA827697 R23653 D20240 AA772517 H13802 R66972 R79360 R27351 F03379 AA031952 N69504 R33143 R79358 R39136 R38800 R15089 R52937 R37502 H01021 R33634 R46551 Z40404 BG291052 BG570357 AW391046 BG496872 H23558 424571 9758_1 BE379766 AW152643 Ai803450 A1564343 Al092711 Al140525 AW152156 A1620740 A1554689 A1161209 A1290242 A1339745 A1374611 A1347388 AI858296 AI140529 AI366124 AA493912 AA406235 AA493889 A1057160 AW022264 A1097277 AI144126 A1080051 AA983529 AA860507 N53469 AA843767 N81163 N70628 AA424577 AA983537 BF003004 AA626688 AA235977 A1057152 A1095366 A1095356 AA458646 AW 194479 AAt 50439 Al375272 AW571777 A1359198 AA993793 BE614394 BE738239M127883AI034344 T59504 D81608 AA908704 AW051665 AA382785 AA307208 N24639 AI370715 BE244980 AA548596 AW449675 AI191008 BF223749 N70752 N22266 A ! 191012AA028001AM19106BF215661BF591548 BG942356AI474968 BE858217 BF793358 AV756758 BG483603 A1093724 BF693395 BG545345 AI744294 T59549 AA811773 BG499757 420787 55832 7 BE674920 AA564248 AA280309 456332 21353 10 BG740624 AV720262 BG198346 BG215119 AW841716 AA228357 AW841786 418479 175360 1 8F966791 BG564455 BE672212 A1151416 AI566231 AI417585 AI378391 AA236264 AI337574 AI346166 AA406590 AA748618 AVY771957 AA478626 AW338072 Al889444 Al810315 BE503662 BG231886 Al888230 Al289102 BF594633 AW074094 AW512456 AA832229 A1056108 A1025868 A1245806 D61957 A1093841 A1721013 A1597594 AA993022 All 28620 A1285106 W37459 W35410 N90037 AA890323 R39943 A1468741 AA829976 AA479201 A1539018 AA875875 AA448827 AW779493 Z39056 H84925 AA223923 AW517592 Al804400 M911882 BM353143 D62885 AI457883 AI880626 R31694 R42772 R68804 R44147 R71463 AV742540 BF966987 431628 30288_1 AF146277 NM 012120 AF164377 AW976054 AW662923 AW770101 AL597184 AA713959 AA808021 AW444640 A1018159 AL050105 AW958324 B1858773 BM312584 BF594436 A1629024 AA311487 BG617872 AW629675 AA384810 AW953668 BF171208 BE768429 BF326254 AW181992 AW118462 AW572001 BG533184 AA768779 AA825697 AA808149 BF036424 AJ420469 AW175925 AA173981 AA557142 AW302163 AW088608 AA847195 Api418480 BM353163 A1015673 A1357621 AI374592 AI245029 AI580659 AI370154 AA767503 AA643885 BM091307 BG496655 AW364502 AW377222 AW371202 BE138896 R80586 BM090998 D25882 M85322 AI541363 BF675114 BG926529 AA627866 BE879221 BF594796 BF675714 B1086785 BG190411 BG217933 BG219447 BF886143 BG403278 426101 3211_1 AL049987 BG620667 BG571984 AW362842 BE150456 BE326465 AW872412 AA868553 A1024689 AA442638 AA813604 AA442648 AA663108 AA442379 AA229448 N56349 AA460220 AW971193 AA453725 A1742087 A1860142 AW769479 At917507 Api860141 BE045272 AW277065 Api921333 AI354470 BE466760 AI82798J A1005467 AA833517 AA563934 AA522837 AA812876 AW020895 AA600372 AA663178 A) 187977 AA229164 AW270324 AA703066 T78981 AA632986 BE708493 R31132 Al253986 Al916737 T84796 T84294 AW961515 AI459289 BF109829 81491853 A1084517 AW103830 BE835233 A1472712 AV741009 AA551512N28268 AA436880AA447794 BE835410 BE835385 BE818352 BE818350 R64648 BE646467 AA493776 AA437299 BE818343 R95914 R31089 BF576826 AU186065 BF802058 Al217018 M247541 Al191725 BE766918 454947 1083824_1 AW846590 AW846615 AW846584 AW846592 AW846621 AW846610 438962 195763 1 AI207343 BF813684 BF928775 AA828585 431693 1414_4 AB075855 M799883 Al952039 BM313847 AW167132 AW264027 AI394192 BM272158 BM272359 BG057287 BE464852 Api620722 BE046016 A1758979 AW474705 AW474624 AW440580 Al239435 AW002172 Al458169 Al634183 Al125609 Al951377 Al631154 Al453490 Al857358 Al469756 BG683503 Api434048 F09546 AW518770 BF855622 Al659151 AA985193 Api814412 AW298184 H09775 AI869379 AW207026 Al659678 Al826075 BF940660 AA744971 C00469 Api672560 AL045697 BF847489 BF842860 T65400 Api863491 H24845 T54772 BE090906 BE090917 BE090877 AA152265 BE244301 B1038346 B1038045 W94876 AA093121 B) 523346 AW470130 N92723 AA258877 R62397 B1523168

450515 13638_2 BE299605 AI589870 AA847598 AI470122 BF939896 AI304356 BE223045 BF435800 Al394207 Al708171 AW025415 A1079409 AW008420 AW304226 N34543 AW603578 AA526961 AA983631 N99134 AA626645 R45023 AA902417 AW672925 AA449985 AA953982 AW675471 AA010062 N80194 H14620 H28475 H26247 BF333581 AW842369 H06848 H05608 H81745 H15016 R51905 AA860423 AI860904 AA876023 434230 41110 1 AF119900 NM 018539 AA702388 N53043 BF351064 N70103 AI207469 AA551569 AW383189 W00906 W00935 N54252 448144 48653 1 BC015871 Al521618 Al471709 AW169230 BG539605 Bl058963 Bl058949 BG548398 BG952412 AW842037 AW842040 AW890573 453225 12287_1 AK054673 Di6294 NM 006111 BC001918 81758758 AU125294 AU121192 AU118572 AL517117 BE793962 BI826721 AW149620 BG721751 81916889 BE795064 Api934471 BF435179 BE797475 BG744432 BF733017 B1261710 BF435252 BE267474 BE219495 AV653212 AW248975 B1832737 BE264857 BE386198 AA773811 Api826904 BF732388 Api281977 BF732958 BF434612 AA480672 BF724595 AA058529 BG500189 AV687020 AA934427 AV696822 BG674590 81262247 BE748762 BG568992 BG180336 BE748454 BG876983 BE222517 W61060 BG993321 BG742061 BG696266 BG740805 BG698598 AA031863 AF006747 AA129619 BG745080 H29767 AA011078 T88743 BG216950 Api608941 AW166202 AA522692 Al927649AW237367 AI935538 AI689743 AW966083 BE326704 AU147054 AW129250 BE463425 AU148980 AI242161 AW615658 AU145096 BE465120 AU159062 At679419 AW473145 BG236394 Al292110 Al985496 M995857 BE551066 Ai632625 AW511387 Al080003 AW243240 Al640340 Al075293 AW205957 Al679929 Al681080 Al753324 BF593137 AW337148 BE326667 Al637787 Al659936 F22148 AI332985 A1650925 AW248532 BE048931 F30242 Api524808 BE939886 Al340251 AS62198 BE463831 Al347479 BE221712 AW193412 BF434502 BE939895 Api373314 AW270842 AW024782 AI272109 AW772225 AW052130 F36818 AW269249 AW838580 AL565549 A1927017 A1821667 AI796037 AW772479 AA995455 AA470517 R00503 AI765977 BF196432 AW341091 AL517116 BG683620 F26241 AA160675 AU160539 BG876391 BF083008 Api795938 BF739968 Al001107 Al985556 BE792113 BI760B79 BG545253 BE313692 AI339338 BF195296 AA352395 BE258769 AAt60087 AA781222 AA100912 BE886334 AL534518 H02114 BG740469 AA330736 H93354 BE622370 BG426627 AA352143 BG743030 BG695884 W42513 BG674719 AW802577 BF313256 AA188326 BF211944 BG489143 T68371 AA773564 AA470563 W42415 T61648 AA173985 AI695223 AI640567 AI915875 AI640318 AA669837 AA743161 AA834774 AA186698 A1766899 AA031697 AAl 29593 D25761 AA100913 AW134585 AA129330 BF434518 BE622820 AA587251 AW149318 H07926 R40908 AA011079 BE967287 BE253428 Api681438 445493 423456 1 AV711317 Al809638 Al808768 Al240593AI915771 417054 12405_2 BG533564 BG618564 AW296119 Al269233 BF508328 AW364777 AW292258 AA371049 Al452471 AlOS2522 BG618376AL049080M631068 BG564643 T53833 AV702544 BG533452 AV705004 AA588281 T28665 BG569026 AV646874 AV647253 AV647455 AV647749 bol759444 AV652457 AV695354 AV696010 AV697248 BG617586 AV722549 AIU5836 Al590676 Al245019AW3382U M530898 D52191 Al435352 D57473 BG566952 Al420505 M035245 AV704972 BG564113 Ai439237 Api287456 AV695686 AA349017 408138 14592_2 AW374043 BG568336 AW374058 AW961372 AA328028 BF438186 A1268678 AV724415 BG029720 AA725816 AI926580 BM310209 AA968470 BF430989 A1185775 AW002091 A1969941 A1718705 A1360440 AWD08856 AA862294 AA625752 A1610753 AA471020 AA723203 AL044614 D80637 H77377 AA745928 AA743114 W25004 AI127139 AA953939 AA908426 AI800072 AI417080 AW874111 AI439293 AI370639 AI277179 AA883338 AA469058 AI200997 W94913 AA047S44 W91966 W69102 W84439 W52870 W67288 W69103 H98077 AAt 11874 AI913850 AA535740 N92824 AA973639 W68358 BE170126 T81345 N50135 Al567418 W67220 BF437728 431926 1237041 1 AW972724 AA877998 AA522631 AU185388 421998 133592_1 B1757233 BG911321 BF351759 AW244016 AW026834 AW024260 AI420138 AA779354 A1093360 AI934858 AW151292 AI373133 AI335587 A1969728 AA101632 BE218525 AI802114 AI783721 AA845265 AW088826 Api832852 F03967 AI611148 AI720358 AW293764 N91161 R79192 W85852 AW771263 BG820263 BG012864 R74441 R86080 W04256 BE707244 BF899452 BE327552 BE669500 Ai492388 Al241532 BF448184 Al209012 AA886528 N70309 AW582776 BF110563 BF448329 BE326537 AW770471 BF444926 BE674147 Al793266AI991774 A1807726 Al218667M301750 R44328 448079 74377 1 AK054894 AW978550 AI984051 AW205843 AW205839 AI379941 AI383948 AW129532 BF197455 AI954133 AI668869 AI360826 AW614392 AI619505 AA927599 R64287 A1803003 A1675123 AW023079 A1638324 AW1 34959 AA831069 BE772132 F29901 BF210719 A1376624 AW960171 A1275045 BE856533 AW243724 A1051487 R68631 C17731 Z44230 AA309094 B1837972 AAt 22297 BE929614 BE006483 AA098802 BG252168 BG928816 Bl091300 AW963375M213871 BE925757 T90131 BG426009 BG611801 BE090425 BF672863 BF132610 BF184312 408239 103120 1 AW469418 AA053401 AA053416 436280 36296_1 AK026215 AI201248 BE671206 AA860436 AA730787 AA834507 D79304 D79806 AW961628 A1017068 BE044373 AA322458 AA987927 AA385869 Bl492783AW021853 R79299 N73208 A1016622 N24609 AW192569 AA707819AI690734 R79189 A1535900 AW589301 Api128434 BE838011 BE837891 BF894555 H95408 436701 28142-1 Z69892 AA210833 BM353155 A1473754 A1147901 A1803109 AA843296 AA418925 A1478552 A1400067 A1360304 AA418828 AW301673 BE218952 Al632804 BF433234 M394157 BF378047 BE467036M319724 AW290940 Al222671 Api347724 AW001711 Al028652 AA398130 Al470582 Ai915936 AA908929 C75102 N36920 H50440 A1919034 A1004399 A13a3862 Al123606 AA648518 AA516258 A1865321 N22865 AA848101 Al589792 M758196 AA214630 A1373911 AW194733 AA213447 A1290291 BF437165 AA757592 BF086904 AW959032 AW992466 BF446888 Api936337 BE938849 AW149064 Al701629 N90021 424399 21961 NM 058173 AF414087 W72837 BF742809 AW070916 BE092421 A1905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 AI139456 BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 AIt27172 BE815819 Al905624 R75793 BG202313 Api905837 BE815853 437611 240436_1 H93046 M897108 Al652046 M761626 BF882276 N68615 T88896 H93912 T84424 414496 1526_1 AK058006 BF724822 W65303 AW887764 AW023806 Z25353 AW022095 AA730973 W00417 W73819 BF982096 Al927669 AW188021 AW770478 AI913512 AA604358 AI697341 AI691028 AI338392 A1079403 H97538 AI144448 AI253102 A1051402 AI335900 AI868132 N28900 H98465 AF268386 Al799915 Al819228 BE048413 AW304723 Al819923 BF223106 AA155907 AW298079 BF055272 BF446804 BF197697 W58588 BF197538 AA032180 AA992597 AW590254 AA027824 A1129369 A1131331 A1655843 AA932907 AW104493 A1150615 BFI 10226 AW172271 A1312659 AA057312 BE673669 AA722984 AW104985 AI129232 A1078648 AI653086 AI703481 AW515897 AI352206 N67076 AW297281 A1686162 AA029184 AI610743 AW772016 A1091778 W65401 AI687374 AI218085 AI765158 A1018002 AI653068 AI335704 AI520850 AW275228 AW275204 A1420247 AA975336 A1697042 AW182235 M736386 Al281682 AW169698 AW263325 BE645834 A1377438 A1146706 AA613808 AA716538 B1496247 AA032248 A1698930 A1193399 N70026 H86792 AA404489 W61267 BF447230 AA910805 AA150774 AA621907 AA902526 A1827634 AW022037 BF059000 B1496246 BG577007 BG571077 AA460779 AW816890 AW816893 AW816891 AA029183 AA010295 H86850 T83320 BE160823 H12925 N40087 AA096372 BE160847 AW816892 AW816889 AW816882 AW816868 AW816941 AW816578 AW81694DAW816577 A1431628 A1828113 AA033677 AA033654 AA452704 AA317582 AA346971 BF836584 H48669 81861605 BG925200 AA463277 H89048 AA155952 W03252 W01510 W00915 W58589 AA164519 N24017 N24622 N27149 N70109 R43771 AA010296 W84611 H98889 H88965 AW594424 AA034139 AA065223 N99696 BG981481 N94371 AA767970 W47146 N70977 H05510 W61268 T90796 AA164518 W47244 AA150883 AA034138 BF338483 F13671 H51317 W72716 N21488 Al188071 Al370541 Al754442 AA148524 Api749182 W95221 W92522 R20385 441925 59915_1 AK057669 AK054977 AL519747 BE893744 BM313248 BG913430 H80793 BF813504 N36311 N39276 H95973 BF791919 BE739392 BE144239 AA074615 AI291059 AI681053 AA702355 BF439899 AW055166 A1096957 BF223853 AL119659 Al692209 BM312961 AI869297 BE466252 Api292024 AA402764 Al214620 M765312 BF380770 AA442682 AL519746 AW295039 A1037878 AW473433 A1499437 A1401618 Al130831 M427406 Al042138 BG272488 Al828769 Al828764 Al189390 W84635 AA398496 AA761672 AA699520 A1200406 N68093 AI143913 AA993133 AA613306 A1050971 AA661905 AA722687 A1749977 AA829345 BG057324 BF001339 AA910169 AA765133 At360722 Al701849 Al365083 H95974 Al830377 Al312866 Api370491 BE858907 N62185 AA705746 BE379632 W93803 Api440333 AW367670 AW367640 N77131 BF993216 A1858263 W52329 N68106 R83113 R85153 BE380058 AA082537 AA729731 W23495 W31190 BF995236 BF968827 BF355168 N24508 AA215711 BF170735 AA280395 BE738851 AW367707 AA630879 AA428420 R76236 BG567847 N25931 AA173568 Al073567 M004957 Al539585 N95093 H99798 H95072 H96853 AA215712 AA034214 R85096 H82051 H80794 R44954 AA278972 H68352 H68346 R94750 R89010 R67951 H65817 N24891 AA173731 Al693577 BE181027 AA709461 BE181002 W60239 BF987598 BF995279 H17483 R76237 AL119133 BF964815 AW663315 H65903 H17591 R20167 AA310039 R58734 R58506 440030 843417_1 AW467127M932693M861SoS 446515 li38Z-l BE178766 A1909166 W79619 AA346208 N54022 R98542 AA005419 AA890703 AW510832 BM126988 BF528760 AA858017 BM1 26698 A142329i AW173383 AA742205 Al693060 AA746651 AA490661 AW241710 AI635076 A1073737 AA875841 AA907556 N50889 AW438573 AW273496 AA633604 AW303990 At685291 A1076127 AW470084 Al022394 Al298624 M253418 W79538 AA719820 AA253398 Al400823AW294450 Al022396 M907775

BF445607 AA699324 AA025643 AW573103 AI167444 AA580002 AW103144 AI640654 AA857115 AA923021 A1066439 AI358865 AA843287 AI824604 AA732370 AW002202 AI219540 AA621697 AI950639 AA904277 AI867527 BF437695 AA808593 AI784144 AI648539 AV752557 AV752603 AA025642 AA764744 AW149075 N30700 H92303 W79523 AI762795 AA282784 H78923 AA252879 H98107 R23754 AA005152 N99239 N74632 H80133 H24710 R38907 R66368 R42466 R52648 H11010 R98493 410453 1027545_1 BE065904 AW749036 BE175748 BE175746 BE175747 BE175745 T64217 454065 517162 1 BE394588 AW024754 BE183167 BE183166 BE378353 426143 3806_1 BC005265 BG176720 AW006027 BM352064 AW026316 A1635822 A1880584 A1693769 A1092211 B1492387 A1400449 AW166297 BF939910 AA232282 AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 A1092748 AA993184 AI126077 A1081758 AI240686 AI261863 AI378423 AA465237 AI376096 AA035579 A1087306 AA448162 AA129977 A1090903 A1080686 A1288939 N33004 Api801240 AW021546 Al370773 Al086064 AA669528 AI250053 AI870113 AA853181 AA858014 BG055562 BG939559 AW080765 AA032283 AW467587 H40506 D00762 NM002788 AA641134 Ai582295 A1417525 Al563975 Al093566 Al707743 Al290741 AW073417 BE875418 BM264076 BG876884 AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569 BG878291 BG876450 AW819099 A1908570 AA449871 AU 135228 BM478404 BF126296 AA375499 AA248473 412477 8669_2 AI220117 AI857837 AI218371 BM091400 AI304964 AI198508 AI400738 AW571549 AW950042 A1089943 AA437280 AU150878 BF197070 AI267984 BF594181 BF196688AI433152 AI338921 AI620364 AI280197AA652531 AI674938 AI342447 AI620350AI281295 AI148621 N54787 AI338121 Al281153 N51899AI087072M954788 AW069054 Al346309 BG529629AI340135 BF083036 Al167365 AW819657 M935468 Al467868 AW148701 AI383720 BE047685 AW015498 AA937149 AA708346 AW771478 AW802508 H53334 AW389204 AW798230 AI553922 AI560688 AW950043 AI961682 AV706506RO1853AA126514N62757AI536893AI926052A141872ON999fAA1 568933AI915737AI080691AII85358N48996N68575H82824H60037 AI247247 T95664 BF593863 AI749637 AW088541 AA991294 AA887452 A1073726 AA633132 AA629674 AA629649 AA629656 AA578595 AI168758 AA804572 A1085786 AA994396 AA991209 AA948663 AA929054 AA927952 T87001 AA928210 AA629296 AW802267 AW384129 BF744400 AA194110 AI382839 AA194837 AA406284 AI250750 R37035 Al525586 W01244 400295 2196_1 NM058173 AF414087 W72837 BF742809 AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 AI139456 BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 Api127172 BE815819 Al905624 R75793 BG202313 Au905637 BE815853 441128 20932_1 BC014072 BE328850 AI356567 AI148171 A1022165 BG149661 BF000671 AA233101 AA573721 AA447991 AW016855A1005068 AA554071 BF478215 AA906902 AW014761 BE905651 BE512923 BM047129 AA243852 AA232991 AA127550 AA127551 AA570256 A1473237 BF033706 N90525 AW973623 A1359627 BG674574 BE903322 450860 40397_1 AK026697 BE938558 BE843975 BE843962 AW3043t3 AI735759 AA021055 AI769145 AI188319 BF064105 AI677654 AA723627 AA781580 AI611167 BE162152 R77997 BG059091 AV722360 AA370451 AA033786 AV729790 AW953851 AW953855 BE504303 A1765853 BF059302 AA410685 AI978745 AA399236 BG149495 BE670366 Al694777 BE503109 M633474 Al700568 Al432181 Al637714 AW302164 M196790 Al928519 BE673464 BF437523 Al281974 Al306156 AW418884 AA523952 AA683187 AW075563 AA877270 AW204404 AW771341 A1913892 AW770312 AW242851 AU154858 AA021007 AI521932 AA03404d AI760631 R34679 Al915923 Al911609 AW242360 AA059025 AA370450 BF432186 AW862279 AW859976 BE159936 BF514075 B1057841 R34781 R77900 AA011413 414665 23751 3 BG567713 AW665841 AI814924 AW978339 AW264036 AI373950 AW 183t57 AW082249 AI201658 AI364196 AA150743 AA160873 AA453757 BF871646BF871640AA565311 AA989511 R10152AA807154T77900AV751591 432908 452541_1 AF150424 Al861896 M570057 AV738855 434433 111338 1 AA633408 AW749955 AW629759 AI651005 415409 34886_1 AKO56188 BM455117 BG527027 AA480032 AW993701 AA164703 AL537682 AA836491 AA515961 AL537681 BF437856 AA683484 AWi 52367 Al769509 M907521 AW105404 AI521557 AA670165 AI564471 N22106 AA479060 Al472006 AA164704 N30335 AI224391 AA969890 BE856571 Al284716 M918763 M773661 BG942266 AA507486 A1934383 AA502847 AA516351 AA653124 AI360432 R75834 AA636111 AI972795 81870444 BE891404 Al631952 Al346655 Al285030 M928471 AL520908 AA385324 D80465 D80464 Al554371 Al907655 BF221524 A1091545 AA411631 A1028196 AA406581 AA228115 AA227977 BG929224 BF593158 408839 234669_1 Al355222 BF378422 AA366587 BF874552 AW277084 R26970 D79194 R27662 432093 1237011_1 AW972670 M525808 H28359 H28383 425097 23175_2 AF070570 BF439282 BF109960 Al480268 Al038060 AW082339 BF516290 BE21821 4 Al469956 M039955 BE644674 A1861871 AA766231 AA845840 W85716 AA676253 A1087188 AA022908 AW953178 T33195 BF594711 AA488969 R55652 D81245 D80778 D81560 AW960933 BF930897 BE698103 AA040024 BF515960 BE168475 AA453247 AI267601 R60894 R44223 T33194 AA114936 W31640 W38829 W39109 AA004849 H41952 W88634 BF031932 BM423354 AL041825 H29654 A1908178 W85754 A1905762 AA309860 C04540 AA340246 H84669 436314 142774 1 AA708982 A1095911 A1983409 406997 29867 1 NA 417314 2097082 1 N68168 N69188 N90450 433738 593682-1 AL037666 AW607643 Api280025 AL037665 AW291619 Al280142 AA765506 Al684802 AW085941 Al688062 410531 1030559 1 H88044BE156092 AW752953 442987 66995_1 BC016329 BG530458 AW811919 AW811918 BG777252 N28284 M280517 N26361 BG612488 Bl491654 BE042557 Al921004 AW665869M845400 BF057417 Api735558 BM146017 AI538936 AI439915 AI745155 AA993066 AA935277 AI161350 AA884866 AI692463 AA938040 AV717682 Al439961 AI439956 AI885932 AI538058 H60829 AA513966 AI24994413943 AI832915 AA565386 AA074079 BM145279 BF791544 AW811909 BF964902 BG113250 N99606 AA312166 BF696463 D61610 AV757976 AA092342 BE972583 BG776159 400228 462_3 NM021724 M24898 X72631 BE550221 BF436030 F18898 AL567477 BG033127 BG747927 BF823716 AA371902 AL137978 AL577786 B1490529 AA021622 AA151679AA745053 AA454168 R85506 AA016015 400307 27110 2 AF005081 BG193848 452467 90115 1 M026381 AW500815 Al806691 AW502933AW303573 BE328059 Al201422 BE673566 AW182125 H13705 439518 23842_1 AF086341 W76326 W72300 424389 1059_4 BG190758 AW961118 W77994 AA339877 AW845121 AW845129 BG18t820 BE716719 AI125483 A1161017 W73951 AI250771 AA912611 AA339786 BE838286 BE838282 BE716636 AA777158 W94063 BE716628 BE716625 BE838371 BF371044 BE716631 BE716402 407394 27110 2 AF005081 BG193848 410669 4273_16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538 417553 258857_1 AL545411 Al096369 BF431750 Al130646 W60065 W80663 M258580 W73279 W76156 W80662 AW058658 Al204699W60115 N56751 N30878 Api769345 R71250 Api363766 R22777 R17009 R27985 R28243 414081 19335_1 B1754027 BF696071 A1351939 BGt51298 AI919334 AI401620 BI770165 W72057 T96158 T29478 AA181252 BG927793 AA714431 AA600749 AA181247 AA614756 AA081092 H52207 BG926934 BF222579 BG899001 N64245 AA953040 AI832406 AA102441 BG928081 AA993445 AA916041 AA987847 AA983329 AA737219 M916443AW128994 Al492560 Al761847 BC005272 NM 000900 X53331 M58549 Bol758966 AL598829 B1754530 BG699770 BE439699 BE440148 AV704365 AV733652 BG212015 BG184149 BG200180 BG212690 Bl761222 BG182079 AW338822Ai925631 A) 423041 AW071181 A) 889836 AW129112 BG925339 A1017633 AA568964 BF725590 A1004210 AI809799 BE083097 BG896220 AW997681 BF668788 BE083134 AW631281 BG193052 BG183095 BE440088 BG185728A) 499579 AA188162 AA864282 B) 493352 AA155854 AA836749 AA836844 AA985478 AW082299 A1816747 AA450221 AA971294 BE327509 Api719662 BG576669 At479382 BF824747 AI741800 BG982962 A1088473 AA916151 AW473324 BG901177 BE439998 AW023269 BE813871 AW999947 BE839108 AV707983 AA369722 AW796627 AW890608 A1341771 AA302459 81493353 AA366332 AA371104 AA367277 AL547972 BG928011 AI678903 AI699886 AI956165 AA484893 AA643953 AW591063 8203275 BG211093 AI334791 AA916589 AW058266 Al352370 Al143352 M508721 Al928079 D57214 BE045265 AA541785 BG219510 BG201686 BG195572 AW019904 AW089242 AA953322 Api686698 F27562 AA614749 D56645 F20774 F30660 F25646 AW023542 AA827300 AA582214 AI701289 AA228293 AI906950 AA230156 AA384572 AW438988 AA742516 B1490938 AA731082 BF665869 BG190518 AV704158 BE439643 AA910666 AA155913 AA923097 AA975721 AA985555 BG927032 AA948389 AA451625 AA916141 AL572719 AV707258 AW083733 AAt 28053 AI953789 A1911993 AA421798 BG429150 Api915306 Z30130 AA126929 BG926630 AA081013 AA553696 AA916094 BG924321 A1039722 AI954968 AI372839 AI401406 AI538215

428193 430_1 AF105036 U70663 NM004235 AF022184 AU141767 AU141110 AL040569 D44830 81011351 AL575805 AI290876 A1014784 AI393429 AI266211 AW074303 AA620711 BF197792 AW008766. D25944 A1687397 AA621680 AV714408 BF446905 BM314505 BF514079 BM314197 AA845201 AW874084 BE720622 Al 127241 AA236239 A1679709 A1679135 A1572470 AA573434 A1568487 BE049325 AA687950 BG925989 Al338031 Al365073 A1024576 AA298805 H04001 H45668 BG682146 AL552388 81462361 BG547513 BG896863 81256661 431021 10409_1 NM 003312 BC010148 AK000862 D87292 BG709214 BF972766 BG740474 B1771592 81159859 B1820468 81523933 A1869664 AA314620 BF724353 BG194276 BG195282 Bol524679 BF435589 AI300546 AA481682 AW780207 AlB00832 AI380540 BE222877 AW300707 AA481445 AW015893 A1381541 AA768558 AI138198 AA432063 AA948713 AI869485 AI307419 AI336589 AI301672 BF055581 Al312785 Al521208 Al927918 Al989759 M78015 BF718621 AI927654 AI795909 AI335381 BF334524 AW007444 AA706797 AA975178 AA884739 AA443837 AA933897 AI826464 AI271737 AA053419 H79704 A1984483 BG952614 BF345358 AW083336 AA643660 A1478232 AA603071 BE714413AW078660 AW070418 R02364 BG925951 AL568823 AA053459 AA446748 BG954446 BF760569 427391 9048_3 AY007099 AU150467 Al127583 BE735800 Al125772AI373009 Al215670 Al769136 M586848 AW451158 N50799 AA936337 Al355427 BE677905 AW338020 BGt51557 AA657954 AI754947 AW467279 AI128755 BF448136 AI369247 BF439175 BE207948 A1089272 81911455 AA420720 F36980 AI494204 AA953319 AA155753 A1052675 AA044804 AI282678 BG741226 F25798 AA180204 A1682613 AU152630 AA420766 A1373393 AI885767 T03896 BF939430 AA974325 AW072996 AW005963 BG252471 AI192002 AI918908 AA776144 BI834864 AI753954 BE908511 AW628731 AA034958 BF447074 AW194649 Api915192 AL567164 BF691569 AL565970 AW471137 AW276992 AL536717 BF591783 Api571746 BF939172 BG745029 BG575588 B1054960 H51485 AW799491 Api370437 H26413 AA585334 AU151276 AA074274 AA936883 AW131643 AI221650 AW105476 AW952294 H23835 B1035010 F22360 BF849322 400202 11771_2 BE873890 BF745945 AA156007 AA573157 AW874610 AA916387 N75963 BM083306 AW044671 BC013008 NM_002795 D26593 BG118716 Bl910891 BF972860 BG119842 B1094093 AL538757 BE271653 Bol856538 BE909573 BG109826 BE784430 BE899255 B1833973 BM010809 BE621321 BG684956 BE904726 B1871370 AV708990 BF971483 BE29824181197007 BE272092 BG120374 AW963509 BE540572 AV744947 BG943041 AW327463 BG472870 BE393697 N28533 AA316042 N42043 AW404246 AW892094 AA379896 AW801110 AW406977 AA379791 BG941889 BE076254 AA360459 AA379385 AA320056 BG942618 D31230 AA308300 AA360371 AA371733 AA732937 AA494241 W32225 BF745937 Api383690 BG202360 400201 24179_2 NM_006156 D23662 BF038671 Bl670321 Bl603145 Bl666956 BG716628 BG707476 BG768814 BE312007 BF125930 BF037916 BG942671 Api752472 AW009362 BE379126 B1198555 BF126026 N28289 BE388301 BG327102 AI571450 BF038400 AI884649 AI718962 AI742314 AA977058 A1150699 BG944784 AA187402 BG283893 AV712007 W01301 BG774109 W77840 C15672 Bt670016 A ! 752473 AA484409 C14921 N41745 C15220 F30164 AA133181 BF768974 H30334 AA034968 AA384232 AA353297 AW407023 AA337516 F36177 AA374444 AA402758 Al141545 Bl021470 M973914 413659 1526081 1 BE155647 BE155627 406800 00 AA505535 TABLE 65C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Center (GI) numbers. Dunham, et refers to the publication entitled'The DNA sequence of human chromosome 22'Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Nt_position 405121 8102330 Minus 3581&36004, 36587-36684 401203 9743387 Minus 172961-173056, 173868-173928 400494 9714719 Plus 169845-170272 402294 2282012 Minus 2575-3000 404730 8389582 Plus 119832-120016, 124110-124275 403593 6862650 Minus 62554-62712, 69449-69602 403710 6437516 Plus 27413-28978 401905 8671966 Plus 153965-154441, 156599-156819 403108 8980955 Plus 93253-93667 404996 6007890 Plus 3799938145, 3865238998, 3972739872, 4055 402315 7381741 Minus 30728-32065 401131 8699812 Minus 94802-94987, 95804-95887, 96323-96487. 9759 401205 9743388 Plus 167373-167433. 167936-168031 403105 8980016 Minus 145287-145744 401846 7712190 Minus 82775-82823, 82912-83022 406400 9256298 Plus 15531712. 187&2140, 4252-4385, 5922-6077 406467 9795551 Plus 182212-182958 401429 8217890 Minus 86946-87579 404467 8077630 Minus 24951-25853 406587 8189273 Minus 120577-120718 404175 9931117 Minus 107420-107547, 109625-109796 TABLE 66A. DISEASE INDICATIONS AND PREFERRED UTILITIES FOR SELECTED GENES Table 66A provides disease indications and preferred utilities for about 439 selected genes. These genes were identified using Eos/Affymetrix Genechip arrays. Primekey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number UgID : Unigene ID number UgTitte : Unigene tique Disease : diseases indicated for selected gene as described in table 1 and abbreviated as follows : AWPC (androgen independent prostate diseases), arth (arthritic diseases), bph (benign prostatic hyperplasia), blad (bladder diseases), angio (blood vessel diseases), EWS (bone diseases), glio (brain diseases), breast (breast diseases), cerv (cervical diseases), colon (colorectal diseases), esoph (esophageal diseases), fibro (fibro6c diseases), headnk (head & neck diseases), leio (leiomyoma diseases), leuk (leukocyte diseases), hepC (liver diseases), lung (lung diseases), ovar (ovarian diseases), endo (ovarian endometrioid diseases), omuc (ovarian mucinous diseases), panc (pancreatic diseases), pros (prostate diseases), renal (renal diseases), mela (skin diseases), stom (stomach diseases), test (testicular diseases), uter (uterine diseases) Utility : preferred utilities for selected gene as described in the text and abbreviated as follows : CTL (DNA vaccine target), diag (diagnostic or prognostic target), mAb (monoclonal antibody target), s. m. (small molecule target) Primekey Ex Accn UgID Ug Title Disease Utility 400289 X07820 Hs. 2258 matrix metalloproteinase 10 (stromelysin angio, blad, lung, cerv, ovar, headnk, esoph mAbdiag+s. m. 400297 A1127076 Hs. 306201 hypothetical protein DKFZp56401278 breast, blad, colon, pros mAb 400303 AA242758 Hs. 79136 LIV-1 protein, estrogen regulated breast, ovar, pros, stom, uter, blad, lung, headnk mAb 400843 NM003105* : Homo sapiens sortlin-related blad s. m. 402075 ENSP00000251056' : Plasma membrane calcium blad, lung, headnk, cerv, mela, esoph mAbdiag 402901 NM025206' : Homo sapiens hypothetical pro blad CTL 404287 FGENESH predicted novel CUB-domain conta panc, lung, colon, uter, esoph mAb+s. m.

404682 ortholog of mouse polydomain protein panc diag 404875 NM_022819': HomosapiensphospholipaseA2 blad CTL<. m. 404977 Insulin-like growth factor 2 (somatomedi blad, ovar mAb+diag 405033 C1002652' : gi544327spQ04799FM05 RABIT blad s. m. 405547 NM018833' : Homo sapiens transporter 2, A cerv, mela mats. m. 406400 kallikrein 8 (neuropsin/ovasin) (KLK8) ovar, uter diag 406964 M21305 FGENES predicted novel secreted protein angio, blad, fibro diag 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, glio, blad CTL 407792 A1077715 Hs. 39384 putative secreted ligand homologous to t ovar, uter, cerv, panc mAb+diag 407811 AW190902 Hs. 40098 cysteine knot superfamily 1, BMP antagon blad, panc, stom, uter, lung, esoph diag 407836 T79340 Hs. 22575 B cell CLLfymphoma 6, member B, zinc fi angio CTL 407975 X89426 Hs. 41716 endothelial cell-specific molecule 1 angio, renal diag 408243 Y00787 Hs. 624 interleukin 8 blad, stom, headnk, cerv, lung, angio, esoph, panc diag 408367 AK001178 Hs. 44424 Homosapiensorphanneurotransmittertra mela mAbff. m. 408369 R38438 Hs. 118747 SLC15A2 Solute carrier (amily 15 (H+/pep pros, lung, fibro, uter, glio, cerv, ovar mAb 408380 AF123050 Hs. 44532 diubiquitin lung, blad, headnk, panc, stom, fibro, esoph, mela CTL 408482 NM_000676 Hs. 45743 adenosine A2b eceptor iung, esoph, headnk mAb+s. m. 408562 Al436323 Hs. 31141 roundabout (axon guidance receptor, Dros uter, fibro mAb+s. m. 408790 AW580227 Hs. 47860 neurotrophic tyrosine kinase, receptor, Nng mAbs. m. 408908 BE296227 Hs. 250822 serine/threonine kinase 15 blad, lung, headnk, stom s. m. 409041 AB033025 Hs. 50081 Hypothetical protein, XP 051860 (KIAA119 uter, ovar, lung, colon, stom, headnk, breast, panc CTL+diag 409079 W87707 Hs. 82065 inteAeukin 6 signal transducer (gp130, breast pros mAb--s. m. 409103 AF251237 Hs. 112208 XAGE-1 protein lung CTL 409178 BE393948 Hs. 50915 kallikrein 5 ovar, breast mela diag 409220 BE243323 Hs. 51233 tumor necrosis factor receptor superfami angio, renal, colon, stom mAb. m. 409348 A1401535 Hs. 146090 ESTs renal, glio mAb. m. +CTL 409389 AB007979 Hs. 301281 Homo sapiens mRNA, chromosome 1 specific glio mAb+diag 409420 Z15008 Hs. 54451 laminin, gamma 2 (nicein (100kD), kalini lung, headnk, panc, stom, cerv, esoph, blad diag 409632 W74001 Hs. 55279 serine (or cysteine) proteinase inhibito lung, blad, headnk diag 409637 AA323948 Hs. 55407 Homo sapiens mRNA ; cDNA DKFZp434K0621 (t enal mAbff. m. +CTL 409663 Api743750 Hs. 98306 KIAA1862 protein renal CTL 409745 AA077391 gb : 7814E12 Chromosome 7 Fetal Brain cDNA ovar, renal mAb-s. m. +CTL 409757 Nom001898 Hs. 123114 cystaGn SN panc, stom, lung, blad, diag 409893 AW247090 Hs. 57101 minichromosome maintenance deficient (S. lung, cerv, blad, test, esoph CTL--s. m. 409956 AW103364 Hs. 727 inhibin, beta A (æ6vin A, æ6vin AB a beast, panc, ovar, colon, headnk, lung, blad, esoph diag 410001 AB041036 Hs. 57771 kallikrein 11 ovar, pros, uter, cerv, lung diag 410055 AJ250839 Hs. 58241 geneforsennelthreoninepnoteinkinase ena s. m. 410153 BE311926 Hs. 15830 hypotheUcaproteinFLJ12691 renal, blad CTL 410274 AA381807 Hs. 61762 hypoxia-inducible protein 2 lung, renal CTL 410309 BE043077 Hs. 278153 alpha-2, 8-sialyltransferase lll panc s. m. 410407 X66839 Hs. 63287 carbonic anhydrase IX renal, lung, colon, stom, ovar, uter, blad mAb+s. m. 410418 D31382 Hs. 63325 transmembrane protease, serine 4 colon, blad, lung, ovar, panc, headnk mAb+diag<. m. 411274 NM_002776 Hs. 69423 kallikrein 10 colon, ovar, uter, cerv, headk, panc diag 411411 AA345241 Hs. 55950 ESTs. Weakly similarto KIAA1330 protein renal mAb+s. m. 411773 NM 006799 Hs. 72026 protease, serine, 21 (testisin) ovar diag 412078 X69699 Hs. 73149 paired box gene 8 ovar CTL 412140 AA219691 Hs. 73625 RAB6 interacting, kinesin-like (rabkines lung, blad, headnk, breast, ovar, panc, angio, tesl, mela s. m. 412580 AA113262 Hs. 17901 similartoCABLEStHomosapiensl mela mAbr. m. +CTL 412609 Z48804 Hs. 74124 ocular albinism 1 (Nettleship-Falls) mela s. m. 412628 Api972402 Hs. 306051 hypothetical protein MGC2648 pros diag 412709 AL022327 Hs. 74518 KIAA0027 protein glio mAb-,-.. m. 412719 AW016610 Hs. 816 ESTs lung, headnk, blad, glio, cerv s. m. 412959 D87458 Hs. 75090 KIAA0282 protein glio CTL+s. m. 412986 X81120 Hs. 75110 cannabinoid receptor 1 (brain) glio mAb. m. 413048 M93221 Hs. 75182 mannose receptor, C type 1 fibro, panc mAb 413063 AL035737 Hs. 75184 chitinase 3-like 1 (cartilage glycoprote glio, ovar, blad, lung diag 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa panc, lung, blad, breast, cerv, ovar, headnk, esoph, mela, stom CTLs. m. 413324 V00571 Hs. 75294 corticotropinreteasing hormone Mad diag 413385 M34455 Hs. 840 indoleamine-pyrrole 2, 3 dioxygenase blad, lung, mela, fibro, uter s. m. 413554 AA319146 Hs. 75426 secretogranin 11 (chromogranin C) panc, glio diag 413719 BE439580 Hs. 75498 small inducible cytokine subfamily A (Cy panc, lung, headnk, cerv, colon, uter, stom, esoph diag 414577 A1056548 Hs. 72116 hypothetical protein FLJ20992 similar to angio CTLdiag 414774 X02419 Hs. 77274 plasminogen activator, urokinase lung, blad, headnk, panc, stom, ovar, esoph diag 414812 X72755 Hs. 77367 monokine induced by gamma interferon breast, blad, lung, fibro, panc, colon, headnk, cerv, stom, renal, ovar, test, mela, esoph diag 414825 X06370 Hs. 77432 epidermal growth factor receptor (avian glio, lung, renal, esoph, panc, headnk, arth mAb+s. m.-CTL 414883 AA926960 Hs. 348669 CDC28 protein kinase 1 lung, ovar, stom, colon, cerv, headnk, test s. m. 414907 X90725 Hs. 77597 polo (Drosophiaklike kinase blad, lung, ovar, test s. m. 414945 BE076358 Hs. 77667 Iymphocyteantigen6complex, 10cusE mela mAbr. m. 415138 C18356 Hs. 295944 tissue factor pathway inhibitor 2 angio. panc, stom, lung, uter CTL+diag 415511 A1732617 Hs. 182362 ESTs blad, ovar, renal mAb+s. m. CTL 415539 Api733881 Hs. 72472 BMP-R1B breast uter, pros mAb". m. 415668 AW957684 Hs. 306814 Homo sapiens lysyl oxidase-like 4 (LOXL4 mela diag 415669 NM005025 Hs. 78589 serine (or cysteine) proteinase inhibito lung mAb+diag+s. m. 415817 U88967 Hs. 78867 protein tyrosine phosphatase, receptor-t lung, glio, headnk, cerv, mela, esoph, fibro mAb+s. m. 415910 U20350 Hs. 78913 chemokine (C-X3-C) receptor1 glio mAb<. m. 415929 AA724373 Hs. 304950 Homo sapiens mucolipin-3 (MCOLN3) mela mAb 415989 A1267700 Hs. 351201' ESTs pros, ovar, blad, lung, headnk, panc, colon, stom mAb+s. m. +CTL 416091 AF295370 Hs. 283082 defensin, beta 3 headnk, esoph, meta CTL+diag 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h lung, headnk, colon, uter, stom CTL+s. m. 416250 AA581386 Hs. 73452 Kremen 2 esoph, lung, cerv, ovar mAb+s. m. 416350 AF188625 Hs. 189507 phospholipase A2, group IID test, mela, fibro CTL 416530 U62801 Hs. 79361 kallikrein 6 (neurosin, zyme) ovar, uter diag

416636 N32536 Hs. 42645 solute carrier family 16 (monocarboxylic breast, panc, uter, mela mAbff. m. 416658 U03272 Hs. 79432 fibrillin 2 (congenital contractural ara lung, ovar, uter, blad, angio, test diag 416836 D54745 Hs. 80247 cholecystokinin pros, EWS, glio diag 416857 AA188775 Hs. 292453 FGENESHpredictedTMcontainingprotein glio mAbff. m. 417034 NM006183 Hs. 80962 neurotensin lung, headnk, cerv diag 417079 U65590 Hs. 81134 interteukin 1 receptor antagonist blad, lung, headnk, cerv, esoph diag 417166 AA431323 Hs. 42146 Paired box protein Pax-3 mela CTL 417355 D13168 Hs. 82002 endothelinreceptor lype B glio, mela mAbs. m. 417389 BE260964 Hs. 82045 midkine (neurite growth-promoting factor ovar, lung, blad, uter, cerv, panc, stom, mela, test colon mAb-'diag 417433 BE270266 Hs. 82128 5T4 oncofetal trophoblast glycoprotein panc, breast, Wad, lung, headnk, cerv, uter, ovar, stom, renal mAb 417542 J04129 Hs. 82269 progestagen-associated endometal prote lung, mela mAb+diag 417771 AA804698 Hs. 82547 retinoic acid receptor responder (tazaro blad, cerv, panc, ovar mAb 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 lung, panc, breast, ovar, headnk, stom CTL 417931 W95642 Hs. 82961 trefoil factor 3 (intestinal) ovar, panc, stom, colon, uter, pros diag 417933 X02308 Hs. 82962 thymidylate synthetase blad, lung, angio, colon, panc, esoph s. m. 418007 M13509 Hs. 83169 matrix metalloproteinase I (interstitial lung, blad, fibro, headnk, panc, stom, colon, ovar, esoph, mela mAb+diag+s. m. 418030 BE207573 Hs. 83321 neuromedin B glio, panc diag 418064 BE387287 Hs. 83384 5100 calcium-binding protein, beta (neur me) a diag 418281 U09550 Hs. 1154 oviductaglycoprotein1, 120kD (mucin9 uter, ovar CTL+diag 418478 U38945 Hs. 1174 cyclin-dependentkinase inhibitor 2A (me lung, blad, ovar, headnk, panc, cerv, mela s. m. 418506 AA084248 Hs. 372651 Unknown protein for MGC : 29643 (formerly angio, ovar, glio, uter, lung, blad, panc, mela mAb+diag 418526 BE019020 Hs. 85838 solute carrier family 16 (nionocatboxylic lung, blad, renal, panc, stom, colon, ovar mAbr. m. 418558 AW082266 Hs. 86131 Fas (TNFRSF6)-associatedviadeathdomai esoph, heænk s. m. 418678 NM001327 Hs. 167379 cancerllestis antigen (NY-ESO-1) lung, blad, stom, ovar, panc, esoph, cerv, mela CTL 418830 BE513731 Hs. 88959 hypothetical protein MGC4816 lung CTL 418867 D31771 Hs. 89404 msh (Drosophila) homeoboxhomolog2 blæ s. m. 418870 AF147204 Hs. 89414 chemokine (C-X-C motif), receptor 4 (fus leuk, ovar, breast, blad, renal mats. m. 419080 AW150835 Hs. 18878 hypothetical protein FLJ21620 renal, uter, lung CTL 419121 AA374372 Hs. 89626 parathyroid hormone-like hormone lung, esoph, headnk, blad diag 419171 NM002846 Hs. 89655 protein tyrosine phosphatase, receptor t lung mAb+s. m. 419172 AW338625 Hs. 22026 ESTs : similartoTRANSMEMBRANE4SUPERFangio, enal mAbr. m. 419183 U60669 Hs. 89663 cytochrome P450, subfamily XXIV (vitamin blad, lung, headnk, panc CTL-s. m. 419216 AU076718 Hs. 164021 small inducible cytokine subfamily B (Cy panc, lung, stom, cerv, pros, headnk, esoph diag 419235 AW470411 Hs. 288433 neurotrimin panc, fibro, headnk lung mAb+diag 419452 U33635 Hs. 90572 PTK7 protein tyrosine kinase 7 ovar, pros, lung, breast, uter, test, panc, stom mAb+s. m. 419508 AW997938 Hs. 90786 ATP-binding cassette, sub-family C (CFTR gtio, omuc, stom, lung, panc, colon, renal, uter mAb+s. m. 419556 U29615 Hs. 91093 chitinase 1 (chitotriosidase) lung, fibro, test mAb+diag 419704 AA429104 Hs. 45057 ESTs glio CTL". m. 419723 AL120193 Hs. 339810 longevity assurance (LAGt, S. cerevisiae glio mAb+diag 419741 NM 007019 Hs. 93002 ubiquitin carrier protein E2-C blad, lung, colon, ovar, test, esoph, mela CTL+s. m. 420159 A1572490 Hs. 99785 Homo sapiens cDNA : FU21245 fis, clone C blad, stom mAb 420162 BE378432 Hs. 95577 cyclin-dependent kinase 4 lung, mela s. m. 420208 BE276055 Hs. 95972 silver (mouse homolog) like meta CTL 420370 Y13645 Hs. 97234 uroplakin 2 blad mAb 420440 Nom-002407 Hs. 97644 mammaglobin 2 ovar, uter, cerv diag 420602 AF060877 Hs. 99236 regulator of G-protein signalling 20 headnk, glio, cerv, mela CTLff. m. 420610 AI683183 Hs. 99348 distal-lesshomeobox5 uter, endo, lung CTL 420737 L08096 Hs. 99899 CD70 : tumor necrosis factor (ligand) s renal mAb--s. m. 420789 Al670057 Hs. 199882 ESTs renal mAb+s. m. +CTL 420876 AA918425 Hs. 177744 FGENESpedictednovelproteincontainin panc, blad s. m. 421066 AU076725 Hs. 101408 branched chain aminotransferase 2, mitoc blad, lung CTL". m. 421110 AJ250717 Hs. 1355 cathepsin E blad, panc, stom, lung, fibro, ovar, esoph sm+diaXq 421340 F07783 Hs. 1369 decay accelerating factor for complement angio, panc, stom diag 421379 Y15221 Hs. 103982 small inducible cytokine subfamily B (Cy breast, panc, headnk, lung, stom, blad, cerv, colon, fibro, test, mela, esoph diag 421471 U90545 Hs. 327179 solutecanierfamily17 (sodiumphospha ena mAbe. m. 421474 U76362 Hs. 104637 solutecanrierfamily1 (glutamatetrans lung mAbe. m. 421508 Nom_004333 Hs. 105115 absentinmelanoma2 blad, esoph, lung, mela mAb<. m. +CTL 421524 AA312082 Hs. 105445 GDNF family receptor alpha 1 breast mAb+s. m. 421552 AF026692 Hs. 105700 secreted fizzled-related protein 4 breast, ovar, panc, cerv, uter, pros, lung, stom, headnk diag 421574 AdO00152 Hs. 105924 defensin, beta 2 headnk, lung CTL+diag 421582 Al910275 Hs. 350470 trefoil factor 1 (breast cancer, estroge breast, panc, lung, omuc diag 421666 AL035250 Hs. 1408 endothelin 3 mela mAb+diag 421753 BE314828 Hs. 107911 ATP-binding cassette, sub-family B (MDR/lung mAb+s. m. 421817 AF146074 Hs. 108660 ATP-binding cassette, sub-family C (CFTR lung, cerv, headnk, blad mAb-s. m. 422033 AW245805 Hs. 110903 daudin 5 (Vansmembrane protein deleted glio mAbs. m. 422048 NM012445 Hs. 288126 spondin 2, exUacellular matrix protein panc, pros diag 422109 S73265 Hs. 1473 gastrin-releasing peptide panc, lung, colon, fibro diag 422158 L10343 Hs. 112341 proleaseinhibitor3, skindenved (SKAL headnk, blad, lung, cerv, stom, esoph diag 422163 AF027208 Hs. 112360 prominin (mouse)-like1 colon, beast, fibro mAb-s. m. 422192 AA305159 Hs. 113019 f) s485 me) a s. m. 422260 AA315993 Hs. 105484 regenerating gene type IV colon, omuc, stom, panc mAb-diag 422282 AF019225 Hs. 114309 apolipoprotein L blad, lung, headnk, renal diag 422283 AW411307 Hs. 114311 CDC45 (cell division cycle 45, S. cerevis lung, blad, test, cerv, headnk, esoph s. m. 422309 U79745 Hs. 114924 solutecamerfamily16 (monocarboxylic mela mAb". m. +CTL 422330 D30783 Hs. 115263 epiregulin panc, colon, blad mAb+diag 422397 AJ223366 Hs. 116051 MYEOV Myeloma overexpressed gene (in a s panc, stom, colon, esoph, renal, blad CTL+s. m. 422424 AI186431 Hs. 296638 prostate differentiation factor blad, panc, pros, angio, colon, stom, lung, mela diag 422627 BE336857 Hs. 118787 transforming growth factor, beta-induced colon, renal mAb+diag 422765 AW409701 Hs. 1578 baculoviral IAP repeat-containing 5 (sur lung, blad s. m. 422809 AK001379 Hs. 121028 hypothetical protein FU 10549 blad, cer, lung, uter, angio, stom, test s. m. 422867 L32137 Hs. 1584 cartilage oligomeric matrix protein (pse breast, ovar, pros, panc, lung, colon, uter diag 422956 BE545072 Hs. 122579 ECT2 protein (Epithelial cell transformi ovar, blad, panc, lung, headnk, colon, stom CTL". m. 423161 AL049227 Hs. 124776 downstream of cadherin 6 (by 3. 3kb) renal, ovar, Mad mAb+s. m.

423184 NM 004428 Hs. 1624 ephrin-A1 pros, panc, renal mAb-s. m. 423242 AL039402 Hs. 125783 DEME-6 protein beast, ena, ovar, pros, coion CTL 423422 AC005175 Hs. 128425 NY-REN-24 antigen glio mAb 423508 AW604297 Hs. 129711 hepatitis A virus cellular receptor 1 renal, colon mAb 423583 AL122055 Hs. 129836 KIAA1028 protein pros s. m. 423634 AW959908 Hs. 1690 heparin-binding growth factor binding pr lung, blad, headnk, panc diag 423673 BE003054 Hs. 1695 matrix metalloproteinase 12 (macrophage blad, lung, headnk, ovar, panc, colon, stom, uter, cerv, esoph, test mAbdiag+s. m. 423936 U77629 Hs. 135639 achaete-scute complex (Drosophila) homol colon, stom, ovar CTL 423961 D13666 Hs. 136348 periostin (OSF-2os) breast, colon, Wad, lung, fibro, panc, headnk, ovar, mela mAb+diag 424008 R02740 Hs. 137555 putative chemokine receptor ; GTP-binding blad, headnk, stom, cerv, esoph mAb+s. m. 424046 AF027866 Hs. 138202 serine (or cysteine) proteinase inhibito headnk, lung, cerv diag 424252 AK000520 Hs. 143811 hypothetical protein FLJ20513 colon, stom mAb+s. m. +CTL 424321 W74048 Hs. 1765 tymphocyte-specific protein tyrosine kin meia. fibro s. m. 424381 AA285249 Hs. 146329 protein kinase Chk2 (CHEK2) lung, colon, test s. m. 424411 NM005209 Hs. 146549 crystallin, beta A2 panc s. m. 424502 AF242388 Hs. 149585 lengsin lung s. m. 424503 Nom-002205 Hs. 149609 integrin, alpha 5 (fibronec6n receptor, panc, pros, angio, blad, lung mAb-s. m. 424620 AA101043 Hs. 151254 kallikrein 7 (chymotryptic. stratum corn ovar diag 424687 J05070 Hs. 151738 matrix metalloproteinase 9 (gelatinase B headnk, panc, lung, blad, uter, cerv, cdon, stom, test, mela diag 424735 U31875 Hs. 272499 shoñchainacoholdehydrogenasetamily biad, beast CTL". m. 424825 AF207069 Hs. 153357 procollageMysine, 2-oxoglutarate 5-0io mela CTLs. m. 424905 NM002497 Hs. 153704 NIMA (never in mitosis gene a)-related k ovar, blad, lung, headnk, panc, stom s. m. 425009 X58288 Hs. 154151 protein tyrosine phosphatase, receptor t renal, fibro mAb+s. m. 425071 NM_013989 Hs. 154424 deiodinase, iodothyronine, type II pros, colon, stom, uter, cerv, headnk, esoph, panc diag 425088 AA663372 Hs. 169395 hypothetical protein FW12015 glio, mela mAb+s. m. +CTL 425115 R44664 Hs. 123956 downstream of : G protein-coupted recept glio mAb+s. m. 425247 NM_005940 Hs. 155324 matrix metalloproteinase 11 (stromelysin breasl, ovar, lung, colon, panc, headnk, stom, uter, cerv, blad, esoph mAb+diag+s. m. 425322 U63630 Hs. 155637 protein kinase, DNA-acGvated, catalytic lung, headnk s. m. 425535 AB007937 Hs. 158287 syndecan 3 mela, glio mAb+s. m. 425650 NM 001944 Hs. 1925 desmoglein 3 (pemphigus vulgaris antigen lung, headnk, cerv, esoph, blad mAb 425721 AC002115 Hs. 159309 uroplakin 1A blad mAb 425723 NM_014420 Hs. 159311 dickkopf (Xenopus laevis) homolog 4 endo, uter, colon CTL+diag 425734 AF056209 Hs. 159396 peptidylglycine alpha-amidating monooxyg lung s. m. 425776 U25128 Hs. 159499 parathyeidhormonereceptor2 ovar, uter, lung mAb+diag 425842 At587490 Hs. 159623 NK-2 (Drosophila) homologB panc, glio s. m. 425852 AK001504 Hs. 159651 death receptor 6, TNF superfamily member blad, lung, headnk mAbff. m. 425883 AL137708 Hs. 161031 Homo sapiens mRNA : cDNA DKFZp434K0322 (f blad, panc mAb 425921 NM007231 Hs. 162211 solute carder family 6 (neurotransmitte stom, panc mats. m. 425998 AU076629 Hs. 165950 fibroblast growth factor receptor 4 renal mAb+s. m. 426028 Nom001110 Hs. 172028 adisintegrinandmetalloproteinasedoma biad mAb+diag 426215 AW963419 Hs. 155223 stanniocalcin 2 breast, lung, renal, colon, ovar, uter mAb+diag 426227 U67058 Hs. 154299 Human proteinase activated receptor-2 mR panc, lung, colon, esoph, stom mAb4. m. 426322 J05068 Hs. 2012 transcobalamin I (vitamin B12 binding pr panc, blad, stom diag 426344 H41821 Hs. 322469 transcrip60nalæbvatorofthec-fosp glio CTL". m. 426427 M86699 Hs. 169840 TTK protein kinase ovar, lung, headnk, cerv, colon, uter, stom, test CTL". m. 426451 Al908165 Hs. 169946 GATA-binding protein 3 , T-cell receptor blad, beast s. m. 426514 BE616633 Hs. 170195 bone morphogenetic protein 7 (osteogenic ovar, colon, blad, lung, cerv mAb » diag 426600 NM_003378 Hs. 171014 VGF nerve growth factor inducible mela diag 426761 A1015709 Hs. 172089 PORIMIN Pro-oncosis receptor inducing me lung, esoph, pros, uter, panc, colon, ovar, headnk mAb". m. 426812 AF105365 Hs. 172613 solutecanierfamily12 (potassium/chlo enal mAbff. m. 426890 AA393167 Hs. 41294 ESTs renal, colon, ovar, uter, stom CTL 427239 BE270447 Hs. 356512 ubiquitin carier protein lung, blad, test, mela CTL<. m. 427335 AA448542 Hs. 251677 G antigen 7B lung, headnk, blad, mela, esoph CTL 427343 AI880044 Hs. 176977 protein kinase C binding protein 2 glio CTL+s. m. 427722 AK000123 Hs. 180479 hypothetical protein FLJ20116 colon, stom, panc CTL 427747 AW411425 Hs. 180655 serine/threonine k nase 12 blad, lung, ovar, stom, test, esoph s. m. 427923 AW274357 Hs. 301406 FGENESH predicted 11 TM protein mela mAb 427969 NM001963 Hs. 2230 epidermal growth factor (beta-urogastron panc mAb+diag 428093 AW594506 Hs. 104830 ESTs ovar, panc CTL 428141 D50402 Hs. 182611 solute carrier family 11 (proton-coupled glio mAb+s. m. 428179 Api127772 Hs. 279696 senum/glucocortcoid regulated kinase-li breast s. m. 428187 AI687303 Hs. 285529 G protein-coupled receptor 49 ovar, uter, colon, stom mAb+s. m. 428242 H55709 Hs. 2250 leukemia inhibitory factor (cholinergic ovar, panc,, lung diag 428296 NM003058 Hs. 183572 solute carrier family 22 (organic cation renal mAb+s. m. 428330 L22524 Hs. 2256 matrix metalloproteinase 7 (matrilysin, uter, ovar, fibro, pros, panc, lung, blad, headnk, esoph, mela, stom mAb+diag+s. m. 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin headnk, stom, esoph, colon diag 428392 H10233 Hs. 2265 secretory granule, neuroendocrine protei panc diag 428450 NM 014791 Hs. 184339 KIAA0175 gene product ovar, cerv, panc, lung, blad, meta s. m. 428479 Y00272 Hs. 334562 cell division cycle 2. G1 to S and G2 to lung, blad, colon, uter, ovar s. m. 428484 AF104032 Hs. 184601 solutecamerfamily7 (cabonicamino lung, blad, headnk, «, esoph, glio, uter, stom, colon, mela mAbe. m. 428486 AW583497 Hs. 184604 pancreatic polypeptide panc diag 428505 AL035461 Hs. 2281 chromogranin B (secretogranin 1) panc, lung diag 428513 BE220806 Hs. 184697 plexin C1 mela, panc, stom, headnk-mAb 428579 NM_005756 Hs. 184942 Gprotein-coupledreceptor64 ovar, EWS, uter mAb+s. m. 428664 AK001666 Hs. 189095 similar to SALL1 (sal (Drosophila)-like blad, ovar, pros, lung, stom, test CTLe. m. 428698 AA852773 Hs. 334838 KIAA1866 protein breast, colon, lung, panc, stom, headnk, ovar, EWS mAb 428748 AW593206 Hs. 98785 Ksp37 protein lung diag 428758 AA433988 Hs. 98502 CA125 antigen : mucin 16 ovar, cerv, lung, panc, stom, renal diag 428778 AK000530 Hs. 193326 fibroblast growth factor receptor-like 1 ovar mAb+s. m. 428784 Y12851 Hs. 193470 purinergic receptor P2X, ligand-gated io glio, mela mAb". m. 428841 Al418430 Hs. 104935 ESTs renal mAbs. m. +CTL 428953 AA306610 Hs. 348183 tumor necrosis factor receptor superfami cerv, panc, colon, stem, headnk, renal mAb+diag 428969 AF120274 Hs. 194689 artemin lung, cerv diag

428970 BE276891 Hs. 194691 retinoic acid induced 3 (RAIG1) : metabo stom, panc, colon, ovar mAbr. m. 429149 AW193360 Hs. 197962 Homolog of mouse ADP-nbosyláion factor glio mAb". m. 429211 AF052693 Hs. 198249 gapiunc60npmtein, beta5 (connexin3 lung, blad, heaink, cez, esoph, stom, mela mAb". m. 429263 AA019004 Hs. 198396 ATP-bindingcassete, subfamilyA (ABC1 lung mAb--s. m. 429276 AF056085 Hs. 198612 Gprotein-coupiedreceptor51 angio, blad, glio mAbr. m. 429353 AL117406 Hs. 335891 ATP-binding cassette transporter MRPB breast pros mAb", m. 429547 AW009166 Hs. 99376 FGENESH predicted novel secreted protein panc, headnk, lung, ovar diag 429610 AB024937 Hs. 211092 LUNX protein ; PLUNC (palate lung and nas lung, fibro mAb--, diag 429903 AL134197 Hs. 93597 cyclin-dependent kinase 5, eguiatoz su lung, mela s. m. 429910 NM 000867 Hs. 2507 Shydroxytryptamine (serotonin) receptor leio mAbts. m. 430147 R60704 Hs. 234434 hairylenhancer-of-split related with YRP glio s. m. 430280 AA361258 Hs. 237868 intedeukin 7 receptor'mela, lung, panc, stom, esoph, headnk mAb. s. m. +CTL 430377 NM 001922 Hs. 301865 dopachrometautomerase (dopachrome delta mela CTL 430486 BE062109 Hs. 241551 chloride channel, calcium activated, fam lung, blad, headnk, cerv, esoph mAb. s. m. 430822 AdO05371 Hs. 248017 glyceraldehyde-3-phosphate dehydrogenase mela s. m. 430890 X54232 Hs. 2699 glypican t glio, lung, cerv, blad, esoph mAbs. m. 431053 S40369 Hs. 249141 Glutamate receptor subunit glio mAb 431130 NM 006103 Hs. 2719 HE4 ; epididymis-specific, whey-acidic pr ovar, uter diag 431462 AW583672 Hs. 256311 granin-like neuroendocrine pep6de precu panc, lung, glio, test diag 431515 NM012152Hs. 258583 EDG-7 (endothelial differentiation, lys ovar, pros, lung, blad mAbs. m. 431620 AA126109 Hs. 264981 Z-5'-aligoadenylate synthetase 2 (69-71 esoph, cerv CTL. s. m. 431629 AU077025 Hs. 265827 interferon, alpha-inducible protein (clo panc, uter, cew, stom, esoph, mela mAb+diag 431630 NM002204 Hs. 265829 integrin, alpha 3 (antigen CD49C, alpha ovar, panc, blad, headnk, mela, renal mAb+s. m. 431840 AA534908 Hs. 2860 POU domain, class 5, transcription facto test, renal, Mad CTL 431846 BE019924 Hs. 271580 uroplakin 1B lung, blad, headnk, uter, cerv, stom, ovar mAb+diag 431870 AW449902 Hs. 105500 ESTs renal mAb+s. m. CTL 431939 AW008061 Hs. 231994 ESTs renal, coion mAbff. m. +CTL 431958 X63629 Hs. 2877 cadherin 3, type 1, P-cadherin (placenta lung, blad, cerv, headnk, ovar, colon, pros, panc, breast, esoph, test, mela mAbdiag 432196 AW300888 Hs. 273230 hypothetical protein FLJ10830 renal CTL 432201 AI538613 Hs. 298241 Transmembrane protease, serine 3 breast, on, ovar, stom, panc, uter, cerv, lung mAb+diag+s. m. 432579 AF043244 Hs. 278439 nuclear protein 3 (apoptosis repressor renal CTL 432596 AJ224741 Hs. 278461 matrilin 3 panc, breast diag 432606 NM 002104 Hs. 3066 granzyme K (serine protease, granzyme 3 ; renal, beast, lung, stom, hepC, fibro CTL 432800 BE391046 Hs. 278962 AIM-1 protein meta, pros mAb+s. m. 432829 W60377 Hs. 57772 ESTs blad CTL+s. m. 432867 AW016936 Hs. 233364 ESTs stom, colon mAb+s. m. +CTL 432874 W94322 Hs. 279651 melanoma inhibitory activity panc, stom, mela diag 432990 AL036071 Hs. 279899 tumor necrosis factor receptor superfami pros, renal mAb+s. m. 433001 AF217513 Hs. 279905 clone HQ0310 PR00310p1 colon, breast, lung, blad, cerv, uter, test, mela s. m. 433447 U29195 Hs. 3281 neuronal pentraxin 11 mela, esoph, colon, renal diag 433848 AF095719 Hs. 93764 carboxypepfidase A4 headnk, esoph, lung s. m. 433867 AK000596 Hs. 3618 hippocalcin-like 1 renal CTL 434206 AW136973 Hs. 362915 ESTs, Weakly similar to S69890 mitogen i stom, coton CTL+s. m. 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso mela s. m. 435013 H91923 Hs. 110024 NM_020142 : Homo sapiens NADH : ubiquinone o renal, lung CTL 435472 AW972330 Hs. 283022 triggering receptor expressed on myeloid glio mAb 435505 AF200492 Hs. 211238 intedeukin-1 homolog 1 lung, headnk diag 435869 AF255910 Hs. 54650 junctional adhesion molecule 2 angio, glio mAb 436456 AW292677 Hs. 248122 melanin-concentrafing hormone receptor (mela, glio mAbs. m. 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel glio mAb+s. m. 436481 AA379597 Hs. 5199 HSPC150 protein similar to ubiquitin-con lung, blad, colon, ovar, uter, headnk, test s. m. 436576 AI458213 Hs. 77542 ESTs renal, panc, headnk, lung mAb-s. m. 436608 AA628980 Hs. 192371 down syndrome critical region protein DS blad, lung CTLs. m. 436895 AF037335 Hs. 5338 cabonicanhydraseXII breast, renal, ovar, glio mAb+s. m. 436961 AW375974 Hs. 156704 ESTs lung, panc, renal, uter, colon CTL 436982 AB018305 Hs. 5378 spondin1, (f-spondin) extracellularmat ovar, fibro diag 437016 AU076916 Hs. 5398 guanine monphosphate synthetase lung, blad, cerv, esoph, headnk s. m. 437044 AL035864 Hs. 69517 differentially expressed in Fanconi's an headnk, cerv, lung, Mad. breast, pros, ovar, stom, esoph CTL 437100 A ! 761073 Hs. 14535 Homo sapiens cDNA : FLJ22314 fis, clone H panc, renal mAb+s. m. +CTL 437212 AI765021 Hs. 210775 ESTs renal, uter, ovar mAb". m. CTL 437789 Ai581344 Hs. 127812 ESTs, Weakly similar to T17330 hypotheti lung CTL 437852 BE001836 Hs. 256897 putativeGPCR biad, lung mAb". m. 437938 AI950087 Hs. 369628 gb : wqOScO2. x1 NCl_CGAP_Kid12 Homo sapien renal, ovar, uter, cerv, blad, renal mAb+s. m. +CTL 438380 T06430 Hs. 6194 chondroitin sulfate proteogiycan BEHAB/b glio, mela diag 438549 BE386801 Hs. 21858 Uinucleotide repeat containing 3 mela CTLdiag 438859 AI559626 Hs. 93522 Homo sapiens mRNA for KIAA1647 protein, renal mAbs. m. +CTL 438929 AW195515 Hs. 253177 ESTs renal mAb+s. m. +CTL 438966 AW979074 gb : EST391184 MAGE resequences, MAGP Ho renal mb+s. m. +CTL 439018 AW300887 Hs. 26638 membrane-spanning 4 domains, subfamily A uter, stom, pros, fibro mAb 439223 AW238299 Hs. 250618 UL16 binding protein 2 lung, headnk, cerv, esoph, blad, colon mAb 439477 W69813 Hs. 58042 ESTs, Moderately similar to GFR3_HUMAN G lung mAb+s. m. 439569 AW602166 Hs. 222399 CEGP1 protein breast, AWPC, pros, blad diag 439606 W79123 Hs. 58561 G protein-coupled receptor 87 lung, blad, headnk, cerv, esoph mAbr. m. 439738 BE246502 Hs. 9598 sema domain, immunoglobulin domain (Ig), blad, lung, cerv, renal mAb-s. m. 439759 AL359055 Hs. 67709 Homo sapiens mRNA full length insert cDN colon, stom, panc, lung mAb-s. m. +CTL 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 renal, cerv, pros, headnk, colon, test mAb 440006 AK000517 Hs. 6844 NALP2 protein ; PYRIN-Containing APAF1-li blad, ovar, lung, headnk, test s. m. 440065 W03476 Hs. 266331 Homo sapiens Fc receptor homolog express mela diag 440225 BE295782 Hs. 159 tumor necrosis factor receptor superfami glio mAb 440304 BE159984 Hs. 125395 hepaGGs A virus cellular receptor 1 renal, colon, blad mAb+s. m. 440311 Api733079 Hs. 125407 ESTs, ModeratelysimilartoALUE HUMAN ! renal mAb, m. +CTL 440516 S42303 Hs. 161 cadherin 2, type 1. N-cadherin (neuronal glio, ovar, uter, renal, hepC mAbdiag 440672 AF083811 Hs. 7345 MAD1 (mito6c arrest deficient, yeast, h mela s. m.

441362 BE614410 Hs. 23044 RAD51 (S. cerevisiae) homolog (E coli Re lung, blad, headnk, test, mela, esoph s. m. 441392 AW451831 Hs. 222119 ESTs, Weakly similar to S30433 keratin 1 renal mAb-.. m. CTL 442006 AW975183 Hs. 372210 ESTs, Weakly similar to S72482 hypotheti fibro, angio mAb 442117 AW664964 Hs. 128899 ESTs ; hypothetical protein for IMAGE : 447 breast. lung, blad, panc, headnk, stom, ovar, pros mAb-s. m. 442133 AW874138 Hs. 129017 ESTs ; type la transmembrane protein ovar, uter mAb 442438 AA995998 gb : os26b03. s1 NCI CGAP Kid5 Homo sapiens uter, ovar, renal mAb-s. m. +CTL 443105 X96753 Hs. 9004 chondroitin sulfate proteoglycan 4 (mela mela mAbdiag 443211 AI128388 Hs. 143655 ESTs blad, ovar, lung, headnk, stom mAb+s. m. +CTL 443247 BE614387 Hs. 333893 c-Myc target JP01 colon, lung, blad, panc CTL 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 colon, lung, blad, stom, test, mela CTL 443595 AF169312 Hs. 9613 PPAR (gamma) angiopoie6n related protein renal diag 443646 A1085198 Hs. 164226 Thrombospondin 1 angio, panc, uter diag 443785 AW449952 Hs. 190125 basic-helix-loop-helix-PAS protein glio, uter, ovar mAb+s. m. CTL 443859 NM_013409 Hs. 9914 follistatn lung, cerv, headnk, blad, esoph diag 443987 AW163123 Hs. 10071 seven transmembrane protein TM7SF3 renal mAb+s. m. 444006 BE395085 Hs. 10086 type I transmembrane protein Fn14 panc, colon, lung, ovar, renal, esoph, mela, blad, stom, cerv mAb 444371 BE540274 Hs. 239 forkhead box Mt lung, headnk, blad, glio, tesL mela s. m. 444381 BE387335 Hs. 283713 hypothetical protein BC014245 breast, colon, blad, lung, panc, headnk, ovar, stom, uter, renal, angio, test mela, esoph diag 444488 AW192879 Hs. 355660 ancientconseNeddomainprotein4 ena mAb". m. 444527 NM_005408 Hs. 11383 small inducible cytokine subfamily A (Cy fibro, esoph diag 444781 NM014400 Hs. 11950 GPI-anchored metastasis-associated prote lung, blad, headnk, cerv mAbdiag 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act ovar, lung, blad, headnk panc, cerv, stom, uter, colon, esoph CTL--s. m. 444809 BE207568 Hs. 208219 oculospanin mela mAb+s. m. 445070 NM_000677 Hs. 258 adenosine A3 receptor glio, renal mAbs. m. 445417 AK001058 Hs. 12680 a disintegnn-like and metalloprotease w panc, headnk, stom, lung, esoph diag 445537 AJ245671 Hs. 12844 EGF-like-domain, multiple 6 ovar, blad, uter, breas lung, headnk, renal, fibro, panc, cerv mAbadiag 445891 AW391342 Hs. 199460 DPCR1 protein stom, panc, esoph, omuc, esoph mAb 445895 D29954 Hs. 13421 KIAA0056 protein pros CTL 446051 BE048061 Hs. 37054 ephrin-A3 colon, breast mAbrdiag 446163 AA026880 Hs. 25252 prolactin receptor breast cerv, uter mAb-s. m. 446232 A1281848 Hs. 194691 retinoic acid induced 3 stom, panc, colon, ovar mAb+s. m. 446341 AL040763 Hs. 310735 FGENESHpredic60nsimilartomul6dnug mela mAbr. m. 446619 AU076643 Hs. 313 secreted phosphoprotein 1 (osleopontin, ovar, fibro, panc, headnk, lung, colon, blad, mela, esoph, uter diag 446650 AB016625 Hs. 15813 solute carrier family 22 (organic cation renal mAb+s. m. 446921 AB012113 Hs. 16530 small inducible cytokine subfamily A (Cy breast panc, headnk, lung, fibro, mela diag 447004 AW296968 Hs. 157539 FGENESHpredictedsecretedprotein glio mAbdiag 447033 Ai357412 Hs. 157601 Predicted gene : Eos cloned ; secreted wN colon, pros, fibro, breast, ovar, lung, panc CTL+diag 447072 D61594 Hs. 17279 tyrosylprotein sulfotransferase 1 gtio, panc CTL+s. m. 447131 NM_004585 Hs. 17466 retinoic acid receptor responder (tazaro renal, beast, stom, lung, mela, ovar mAb+s. m. 447208 BE315291 Hs. 237971 hypothetical protein MGC5627 esoph, stom, colon CTL+diag 447269 NM004861 Hs. 17958 cerebroside (3-phosphoadenylylsulfate : g renal CTL 447342 A1199268 Hs. 19322 Homo sapiens, Similar to RIKEN cDNA 2010 colon, blad, pros, lung, stom, AWPC, ovar CTL 447400 AK000322 Hs. 18457 hypothetical protein FLJ20315 colon, pros, stom, uter CTL 447674 BE270640 Hs. 19192 cyclin-dependent kinase 2 meta S. M. 447835 AW591623 Hs. 164129 ESTs. Weakly similar to138022 hypotheti renal, ovar, uter mAbs. m. +CTL 447937 AL109716 Hs. 20034 HomosapiensmRNAhulliengthinsertcDN mela mAbff. m. 448105 AW591433 Hs. 298241 Transmembrane protease. serine 3 breast, panc, colon, lung, ovar, stom mAb-'s. m. +CTL 448243 AW369771 Hs. 367688 integrin, beta 8 ovar, uter, lung, stom, headnk, glio, panc mAb-s. m. 448321 NM 005883 Hs. 20912 adenomatous polyposis coli like glio mAb+s. m., CTL 448499 BE613280 Hs. 77550 p53regulated DDA3 glio CTLs. m. 448595 AB014544 Hs. 21572 KIAA0644 gene product breast glio mAb-s. m. 448610 NM006157 Hs. 21602 net (chickenFlike 1 mela diag 448733 NM005629 Hs. 187958 solute cartier family 6 (neurotransmitte tung, renal mAb+s. m. 448844 AI581519 Hs. 177164 FGENESH predicted novel cell surface pr panc, lung, stom, omuc mabre. m. 449048 Z45051 Hs. 22920 similar to S68401 (cattle) glucose induc panc, ovar, uter, glio, headnk, lung mAb 449444 AW818436 Hs. 351306 solutecanierfamily16 (monocarboxylic ena, panc mAbe. m. 449523 NM000579 Hs. 54443 chemokine (C-C mo6t) receptor 5 lung, panc, renal, stom, hepC, fibro, mela mAb+s. m. 449720 AA311152 Hs. 288708 hypothetical protein FLJ21562 colon CTL 449722 BE280074 Hs. 23960 cyciin B1 headnk, blad, lung, panc, angio, test mela, esoph s. m. 450001 NM_001044 Hs. 406 solutecanjerfamily6 (neunotransmine ena mAbr. m. 450375 AA009647 Hs. 352537 a disintegrin and metalloproteinase doma breast, ovar, headnk, panc, lung, esoph, colon mAbAiag+s. m. 450531 AW301032 Hs. 203800 (BC017500) Similar to hypothetical prote colon CTL 450701 H39960 Hs. 288467 hypothetical protein XP_098151 (leucine-lung, headnk, panc, breast, stom, ovar, esoph, colon mAbdiag 450726 AW204600 Hs. 355462 HUMPSPBA Human putmonary surfactant-asso fibro, lung s. m. 450931 N25156 Hs. 25648 tumornecrosisfætorreceptorsuperlfami lung, renal mAb". m. 450983 AA305384 Hs. 25740 ER01 (S. cerevisiae)-like blad, lung, ovar, panc diag 451099 R52795 Hs. 25954 intedeukin 13 receptor, alpha 2 glio, fibro, mela mAbs. m. 451310 AW250651 Hs. 26213 Human DNA sequence from clone RP3447F3 colon, panc CTL 451527 AF022813 Hs. 26518 transmembrane 4 superfamily member 7 renal mAb 451537 R56631 Hs. 26550 reGnoid X receptor, gamma mela CTL-s. m. 451668 Z43948 Hs. 326444 cartilage acidic protein 1 blad, ovar, lung mAbodiag 451939 U80456 Hs. 27311 single-minded (Drosophila) homolog 2 pros CTL 451979 F06972 Hs. 27372 endothelial tyrosine kinase (Etk) (BMX), angio CTL". m. 451988 AF263928 Hs. 27410 papillomavirus regulatory factor PRF-1 renal CTL 452097 AB002364 Hs. 27916 adisintegnn4ikeandmetallopnotease (ovar mAbr. m. +diag 452190 H26735 Hs. 91668 Homo sapiens clone PP1498 unknown mRNA breast stom, panc mAb 452194 AI694413 Hs. 373599 olfactory receptor, family 2, subfamily stom, panc, renal, colon, mela, fibro mAb+s. m. 452203 X57522 Hs. 352018 transporter 1, ATP-binding cassette, sub cerv, esoph, Mad. stom, mela, renal mAbr. m. 452281 T93500 Hs. 28792 Homo sapiens CDNA FLJ 11041 fis, clone PL breast, headnk, panc, stom, lung, esoph, fibre diag 452355 N54926 Hs. 29202 G protein-coupled receptor 34 glio, fibro, panc mAbr. m. 452401 Nom 007115 Hs. 29352 tumor necrosis factor, alpha-induced pro blad, breast, panc, headnk, stom, lung, arth, renal, esoph diag 452431 U88879 Hs. 29499 toll-like receptor 3 renal, hepC mAb

452747 BE153855 Hs. 61460 lg superfamily receptor LNIR breast, blad, lung, headnk, ovar, stom, uter, panc mAb 452795 AW392555 Hs. 18878 hypothetical protein FU21620 renal, headnk, colon, lung, panc mAbs. m., CTL 452838 U65011 Hs. 30743 preferentially expressed antigen in mela lung, ovar, breast, mela, test, esoph, renal CTL 452862 AW378065 Hs. 8687 ADAMTS2 (a disintegrin-like and metallo headnk, breast, colon, arth, lung, blad, esoph, stem mAbdiag 453195 BE241876 Hs. 32352 hypothetical protein DKFZp434K1210 renal CTL 453496 AA442103 Hs. 33084 solutecanierfamily2 (fæilitatedglu enal, pnDs mAb4. m. 453642 A1370936 Hs. 34074 dipep6dylpeptidase Vi glio mAb+s. m. 453837 AL138387 Hs. 256126 baculoviral IAP repeatcontaining 7 (liv renal, mela s. m. 453857 AL080235 Hs. 35861 Ras-induced senescence 1 (RISt) glio, lung, uter, headnk, cerv, panc, pros mAbr. m. 453968 AA847843 Hs. 62711 High mobility group (nonhistone chromoso lung, uter, blad, test CTL+s. m. 456546 Api690321 Hs. 203845 KCNK1 potassium channel, subfamily K, m ovar mAb+s. m. 456662 NM002448 Hs. 1494 msh (Drosophila) homeo box homolog 1 (fo uter, ovar CTL 456759 BE259150 Hs. 127792 delta (Drosophila)-like3 glio, lung mAb<. m. 457133 M54968 Hs. 351221 v-Ki-ras2 Kirstenrat sarcoma 2 viraion panc s. m. 457489 A1693815 Hs. 127179 crypticgene pane. pros. fung diag 457561 AA331517 Hs. 286055 chimerin (chimaerin) 2 glio mAbr. m. 458079 A1796870 Hs. 54277 Homo sapiens similar to RIKEN cDNA 28100 mela, fibro mAb 458435 Al418718 Hs. 144121 ESTs, Wealdy similar to T46916 hypothefi glio mAb-s. m. +CTL 458627 AW088642 Hs. 97984 SRY (sex determining region Yybox 17 (S ovar, uter, test CTL TABLE 66B : Pkey : Unique Eos probeset identifier number CAT number Gene cluster number Accession : Genbank accession numbers Pkey CAT Number Accession 409745 MH1944_5 BI030997 AA921874 AW188822 81027862 AI347618 AI361453 A1088754 AW207491 AA077391 BG012775 BG997382 AA286833 AA150722 B1007625 Bai027864 BID09100 Bai006275 B1006270 81031000 81029864 81006277 BI007627 81006266 BI006991 81006990 81007763 BI007762 BG997377 AA150780 B1033518 BI027818 BG015789 BI033807 AA341445 438966 1242593 1 AW979074 AA834841 AA828650 442438 24590_1 AK022175 AU 147222 AI124945 AU121400 F07756 AW979025 AA828595 AA828577 BE935573 AA829588 AI743616 BE315309 8E047365 AI761053 AW168960 AA833900 BG679419 BE171071 BF034368 BF754297 R61781 F08149 F07647T77332M897461 Al829714Al376820Ai809991 AW661854 TABLE 66C : Pkey : Unique number corresponding to an Eos probeset Ref : Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. Dunham, et al. * refers to the publication entitled The DNA sequence of human chromosome 2Y Dunham, et al. (1999) Nature 402 : 489-495. Strand : Indicates DNA strand from which exons were predicted. Ntposition : Indicates nucleotide positions of predicted exons. Pkey Ref Strand Ntposition 400843 9188605 Plus 5863-5970, 7653-7784, 8892-9023. 9673-9807, 402075 8117407 Plus 121907-122035, 122804-122921, 124019-12416 402901 8894222 Minus 175426-175667 404287 2326514 Plus 53134-53281 404682 9797231 Minus 40977-41150 404875 9801324 Plus 9658&96732, 97722-97831 404977 3738341 Minus 43081-43229 405033 7107731 Minus 142358-142546 405547 1054740 Plus 124361-124520, 124914-125050 406400 9256298 Plus 1553-1712, 187&2140, 4252-4385, 5922-6077 TABLE 67 : Pkey : Unique Eos probeset identifier number ExAccn : Exemplar Accession number, Genbank accession number UnigenelD : Unigene number Unigene Title : Unigene gene titre Seq ID No : Sequence Identification Number linking the information in Table 67 to the sequences in Table 68 Pkey ExAccn UnigenelD Unigene Title Seq ID No 418007 M13509 Hs. 83169 matrix metalloproteinase 1 (interstitial Seq ID No 1 & 199 418007 M13509 Hs. 83169 matrix metalloproteinase t (interstifial Seq ID No 2 & 200 428368 BE440042 Hs. 83326 matrix metalloproteinase 3 (stromelysin Seq ID No 3 & 201 417866 AW067903 Hs. 82772 collagen, type XI, alpha 1 Seq ID No 4 & 202 444381 BE387335 Hs. 283713 hypothetical protein BC014245 Seq ID No 5 & 203 452281 T93500 Hs. 28792 Homo sapiens cDNAFU 11041 fis. clone PL Seq ID No 6 428698 AA852773 Hs. 334838 KIAA1866 protein Seq ID No 7 & 204 452862 AW378065 Hs. 8687 ADAMTS2 (a disintegrin-like and metallo Seq ID No 8 & 205 432201 A1538613 Hs. 298241 Transmembrane protease, serine 3 Seq ID No 9 & 206 434206 AW136973 Hs. 362915 ESTs, Weakly similar to S69890 mitogen i Seq ID No 10 & 207 422260 AA315993 Hs. 105484 regenerabnggenebpelV SeqlDNo11&208 409041 AB033025 Hs. 50081 Hypothetical protein, XP 051860 (KIAAt 19 Seq ID No 12 & 209 443426 AF098158 Hs. 9329 chromosome 20 open reading frame 1 Seq ID No 13 & 210 443211 Al128388 Hs. 143655 ESTs Seq ID No 14 428664 AK001666 Hs. 189095 similar to SALL1 (sal (Drosophila)-like Seq ID No 15 & 211 413278 BE563085 Hs. 833 interferon-stimulated protein, 15 kDa Seq ID No 16 & 212 452401 NM 007115 Hs. 29352 tumor necrosis factor, alpha-induced pro Seq ID No 17 & 213 452401 NM_007115 Hs. 29352 tumor necrosis factor, alpha-induced pro Seq ID No 18 & 214 408380 AF123050 Hs. 44532 diubiquitin Seq ID No 19 & 215 416209 AA236776 Hs. 79078 MAD2 (mitotic arrest deficient, yeast, h Seq ID No 20 & 216 409757 Nom 001898 Hs. 123114 cysta6n SN Seq ID No 21 & 217 _ SeqIDNO21&217

425921 NM 007231 Hs. 162211 solutecarierfamily6 (neunotransmiúe SeqlDNo22&218 452194 AI694413 Hs. 373599 olfactory receptor, family 2, subfamily Seq ID No 23 & 219 452194 Api694413 Hs. 373599 olfactory receptor, family 2, subfamily Seq ID No 24 & 220 444783 AK001468 Hs. 62180 anillin (Drosophila Scraps homolog), act Seq ID No 25 & 221 422956 BE545072 Hs. 122579 ECT2 protein (Epithelial cell transform ! Seq ID No 26 & 222 424905 NM002497 Hs. 153704 NIMA (never in mitosis gene akelated k Seq ID No 27 & 223 415989 Api267700 Hs. 351201 ESTs Seq ID No 28 415989 A1267700 Hs. 351201 ESTs Seq ID No 29 424252 AK000520 Hs. 143811 hypothetical protein FU20513 Seq ID No 30 & 224 424252 AK000520 Hs. 143811 hypothetical protein FU20513 Seq ID No 31 & 225 432867 AW016936 Hs. 233364 ESTs Seq ID No 32 439759 AL359055 Hs. 67709 Homo sapiens mRNA full length insert cDN Seq ID No 33 428970 BE276891 Hs. 194691 retinoic acid induced 3 (RA) ; metabo Seq ID No 34 & 226 428953 AA306610 Hs. 348183 tumor necrosis factor receptor superfami Seq ID No 35 & 227 428953 AA306610 Hs. 348183 tumor necrosis factor receptor superfami Seq ID No 36 & 228 428953 AA306610 Hs. 348183 tumor necrosis factor receptor superfami Seq 10 No 37 & 229 428953 AA306610 Hs. 348183 tumor necrosis factor receptor superfami Seq ID No 38 8 230 428953 AA306610 Hs. 348183 tumor necrosis factor receptor superfami Seq ID No 39 & 231 452203 X57522 Hs. 352018 transporter 1, ATP-binding cassette, sub Seq ID No 40 & 232 428330 L22524 Hs. 2256 matrix metalloproteinase 7 (matrilysin, Seq ID No 41 & 233 436480 AJ271643 Hs. 87469 putative acid-sensing ion channel Seq ID No 42 & 234 407603 AW955705 Hs. 62604 Homo sapiens, clone IMAGE : 4299322, mRNA, Seq ID No 43 & 235 425115 R44664 Hs. 123956 dowmstream of G pnotein coupled rept Seq ID No 44 & 236 435472 AW972330 Hs. 283022 triggering receptor expressed on myeloid Seq ID No 45 & 237 418870 AF147204 Hs. 89414 chemokine (C-X-C motif receptor 4 (fus Seq ID No 46 & 238 415511 At732617 Hs. 182362 ESTs Seq ID No 47 440304 BE159984 Hs. 125395 hepatitis A virus cellular receplor 1 Seq ID No 48 & 239 423161 AL049227 Hs. 124776 downstream of cadherin 6 (by 3. 3kb) Seq ID No 49 & 240 423161 AL049227 Hs. 124776 downstream of cadherin 6 (by 3. 3kb) Seq ID No 50 410153 BE311926 Hs. 15830 hypothetical protein FU12691 Seq ID No 51 & 241 410153 BE311926 Hs. 15830 hypothetical protein FU12691 Seq ID No 52 & 242 410153 BE311926 Hs. 15830 hypothetical protein FLJ12691 Seq ID No 53 & 243 410153 BE311926 Hs. 15830 hypothetical protein FU12691 Seq ID No 54 & 244 436895 AF037335 Hs. 5338 carbonic anhydrase XII Seq ID No 55 & 245 436895 AF037335 Hs. 5338 carbonic anhydrase XII Seq ID No 56 & 246 421471 U90545 Hs. 327179 solute carrier family 17 (sodium phospha Seq ID No 57 & 247 428296 Nom-003058 Hs. 183572 soWutecamerfamily22 (organicca60n SeqlDNoS8&248 426890 AA393167 Hs. 41294 ESTs Seq ID No 59 249 437212 A1765021 Hs. 210775 ESTs Seq ID No 60 438966 AW979074 gb : EST391184 MAGE resequences, MAGP Homo Seq ID No 61 440311 A1733079 Hs. 125407 ESTs, Moderately similar to ALUE_HUMAN ! Seq ID No 62 437100 Api761073 Hs. 14535 Homo sapiens cDNA : FU22314 fis, clone H Seq ID No 63 437100 A1761073 Hs. 14535 Homo sapiens cDNA : FU22314 fis, clone H Seq ID No 64 450001 NM001044 Hs. 406 solute carrier family 6 (neurotransmitte Seq ID No 65 & 250 419080 AW150835 Hs. 18878 hypothetical protein FU21620 Seq ID No 66 & 251 443595 AF169312 Hs. 9613 PPAR (gamma) angiopoie6n related protein Seq ID No 67 & 252 443595 AF169312 Hs. 9613 PPAR (gamma) angiopoiefin related protein Seq ID No 68 410407 X66839 Hs. 63287 carbonic anhydrase IX Seq ID ilo 69 & 253 453496 AA442103 Hs. 33084 solute carrier family 2 (facilitated glu Seq ID No 70 & 254 420737 L08096 Hs. 99899 CD70 ; tumor necrosis factor (ligand) s Seq ID No 71 & 255 439979 AW600291 Hs. 6823 hypothetical protein FLJ10430 Seq ID No 72 & 256 420789 A1670057 Hs. 199882 ESTs Seq ID No 73 420789 A1670057 Hs. 199882 ESTs Seq ID No 74 441392 AW451831 Hs. 222119 ESTs, WeaklysimilartoS30433kera6n1 SeqlDNo75&257 452431 U88879 Hs. 29499 toll-like receptor 3 Seq ID No 76 & 258 431870 AW449902 Hs. 105500 ESTs Seq ID No 77 431870 AW449902 Hs. 105500 ESTs Seq ID No 78 449523 NM000579 Hs. 54443 chemokine (C-C motif) receptor 5 Seq ID No 79 & 259 409745 AA077391 gb : 7B14E12 Chromosome 7 Fetal Brain cDNA Seq ID No 80 438859 Api559626 Hs. 93522 Homo sapiens mRNA for KIAA1647 protein, Seq ID No 81 409637 AA323948 Hs. 55407 Homo sapiens mRNA ; cDNA DKFZp434K0621 (f Seq ID No 82 & 260 409637 AA323948 Hs. 55407 Homo sapiens mRNA : cDNADKFZp434K0621 (f Seq ID No 83 409348 A1401535 Hs. 146090 ESTs Seq ID No 84 447269 NM004861 Hs. 17958 cerebroside (3-phosphoadenylylsulfate : g Seq ID No 85 & 261 453195 BE241876 Hs. 32352 hypothetical protein DKFZp434K1210 Seq ID No 86 & 262 428841 Ai418430 Hs. 104935 ESTs Seq ID No 87 428841 Ai418430 Hs. 104935 ESTs Seq ID No 88 428841 Ai418430 Hs. 104935 ESTs Seq ID No 89 409663 A1743750 Hs. 98306 KIAA1862 protein Seq ID No 90 & 263 409663 Api743750 Hs. 98306 KIAA1862 protein Seq ID No 91 & 264 431939 AW008061 Hs. 231994 ESTs Seq ID No 92 & 265 432606 NM002104 Hs. 3066 granzyme K (serine protease, granzyme 3 ; Seq ID No 93 8 266 411411 AA345241 Hs. 55950 ESTs, Weakly similar to KIAA1330 protein Seq ID No 94 & 267 433867 AK000596 Hs. 3618 hippocalcin-like 1 Seq ID No 95 & 268 433867 AK000596 Hs. 3618 hippocalcin-like 1 Seq ID No 96 & 269 437938 Ai950087 Hs. 369628 gb : wqO5c02. x1 NCl_CGAP_Kd12Homosapien SeqlDNo97 432579 AF043244 Hs. 278439 nucleolar protein 3 (apoptosis repressor Seq ID No 98 & 270 418526 BE019020 Hs. 85838 solute carrier family 16 (monocarboxylic Seq ID No 99 & 271 432196 AW300888 Hs. 273230 hypothetical protein FW10830 Seq ID No 100 & 272 432196 AW300888 Hs. 273230 hypothetical protein FLJ10830 Seq ID No 101 & 273 438929 AW195515 Hs. 253177 ESTs Seq ID No 102 410055 AJ250839 Hs. 58241 gene for serine/threonine protein kinase Seq ID No 103 & 274 446650 AB016625 Hs. 15813 solute camer family 22 (organic cation Seq ID No 104 & 275

426812 AF105365 Hs. 172613 solute carrier family 12 (potassium/chlo Seq ID No 105 & 276 447131 NM004585 Hs. 17466 retinoic acid receptor responder (tazaro Seq ID No 106 & 277 449444 AW818436 Hs. 351306 solutecanierfamily16 (monocarboxylic SeqlDNo107&278 422627 BE336857 Hs. 118787 transforming growth factor, beta-induced Seq ID No 108 & 279 444488 AW192879 Hs. 355660 ancient conserved domain protein 4 Seq ID No 109 & 280 450931 N25156 Hs. 25648 tumor necrosis factor receptor superfami Seq ID No 110 & 281 409220 BE243323 Hs. 51233 tumor necrosis factor receptor superfami Seq ID No 111 & 282 409220 BE243323 Hs. 51233 tumo necrosis (actw receptor supe (ami Seq ID No 112 & 283 425998 AU076629 Hs. 165950 fibroblast growth factor receptor 4 Seq ID No 113 & 284 425998 AU076629 Hs. 165950 fibroblast growth factor receptor 4 Seq ID No 114 & 285 425009 X58288 Hs. 154151 pnotein qrosine phosphatase, reptor t Seq D No 115 & 286 443987 AW163123 Hs. 10071 seven transmembrane protein TM7SF3 Seq ID No 116 & 287 432990 AL036071 Hs. 279899 tumor necrosis factor receptor superfami Seq ID No 117 & 288 436576 A1458213 Hs. 77542 ESTs Seq ID No 118 & 289 451527 AF022813 Hs. 26518 transmembrane 4 superfamily member 7 Seq ID No 119 & 290 448733 NM005629 Hs. 187958 solute carrier family 6 (neunotransmiñe Seq ID No 120 & 291 410274 M381807 Hs. 61762 hypoxia-inducible protein 2 Seq ID No 121 & 292 125218 H91923 Hs. 110024 Empirically selected from AFFX single pr Seq ID No 122 & 293 436961 AW375974 Hs. 156704 ESTs Seq ID No 123 431630 NM002204 Hs. 265829 integrin, alpha 3 (antigen CD49C, alpha Seq ID No 124 & 294 431630 Nom-002204 Hs. 265829 integrin, alpha 3 (antigen CD49C, alpha Seq ID No 125 & 295 419508 AW997938 Hs. 90786 ATP-binding cassette, sub-family C (CFTR Seq ID No 126 & 296 431840 AA534908 Hs. 2860 POU domain, class 5, transcription facto Seq ID No 127 & 297 442438 AA995998 gb : os26b03. s1 NCl_CGAP_KidS Homo sapiens Seq ID No 128 447835 AW591623 Hs. 164129 ESTs, Weakly similar to 138022 hypotheb Seq ID No 129 429276 AF056085 Hs. 198612 G protein-coupled receptor 51 Seq 10 No 130 & 298 448595 AB014544 Hs. 21572 KIAA0644 gene product Seq ID No 131 & 299 440516 S42303 Hs. 161 cadherin 2, bpe 1, N cadhenn (neurona Seq ID No 132 & 300 456759 BE259150 Hs. 127792 delta (Drosophila)-like 3 Seq ID No 133 & 301 447004 AW296968 Hs. 157539 FGENESH predicted secreted protein Seq ID No 134 & 302 425088 AA663372 Hs. 169395 hypothefical protein FLJ 12015 Seq ID No 135 8 303 409389 AB007979 Hs. 301281 Homo sapiens mRNA, chromosome 1 specific Seq ID No 136 & 304 448321 NM 005883 Hs. 20912 adenomabuspolyposiscoliNke SeqlDNo137&305 426344 H41821 Hs. 322469 transchptionatactivatorofthec-fosp Seq ID No 138 & 306 419704 AA429104 Hs. 45057 ESTs Seq ID No 139 & 307 412959 D87458 Hs. 75090 KIAA0282 protein Seq ID No 140 & 308 448499 BE613280 Hs. 77550 p53regulated DDA3 Seq ID No 141 & 309 458435 Al41871 8 Hs. 144121 ESTs, Weakly similar to T46916 hypothe6 Seq ID No 142 & 310 443785 AW449952 Hs. 190125 basic-helix-ioop-helix-PASpnotein SeqlDNo143&311 427343 A1880044 Hs. 176977 protein kinase C binding protein 2 Seq ID No 144 & 312 416857 AA188775 Hs. 292453 FGENESH predicted TM containing protein Seq ID No 145 & 313 429149 AW193360 Hs. 197962 Homolog of mouse ADP-ribosylation factor Seq ID No 146 & 314 418030 BE207573 Hs. 83321 neuromedin B Seq ID No 147 & 315 457561 AA331517 Hs. 286055 chimerin (chimaerin) 2 Seq ID No 148 & 316 457561 AA331517 Hs. 286055 chimerin (chimaerin) 2 Seq ID No 149 & 317 430147 R60704 Hs. 234434 hairy/enhancer-of-split related with YRP Seq ID No 150 & 318 453642 A1370936 Hs. 34074 dipeptidylpeptidaseVI SeqlDNo151&319 453857 AL080235 Hs. 35861 Ras-induced senescence 1 (RIS1) Seq ID No 152 & 320 449048 Z45051 Hs. 22920 similar to S68401 (cattle) glucose induc Seq ID No 153 & 321 418506 AA084248 Hs. 372651 Unknown protein for MGC : 29643 (formerly Seq ID No 154 & 322 416636 N32536 Hs. 42645 solute carcier family 16 (monocarboxylic Seq ID No 155 & 323 421508 NM_004833 Hs. 105115 absent in melanoma 2 Seq ID No 156 & 324 421379 Y15221 Hs. 103982 small inducible cytokine subfamily B (Cy Seq ID No 157 & 325 428784 Y12851 Hs. 193470 purinergic receptor P2X, ligand-gated io Seq ID No 158 & 326 431958 X63629 Hs. 2877 cadherin 3, type 1, P-cadherin (placenta Seq ID No 159 & 327 417542 J04129 Hs. 82269 progestagen-associated endometrial prote Seq ID No 160 & 328 418678 NM 001327 Hs. 167379 cancer/testis antigen (NY-ESO-1) Seq ID No 161 & 329 418678 NM 001327 Hs. 167379 cancer/tes6s antigen (NY-ESO-1) Seq ID No 162 & 330 420208 BE276055 Hs. 95972 silver (mouse homolog) like Seq ID No 163 & 331 430377 NM001922 Hs. 301865 dopachrometautomerase (dopachrome delta Seq ID No 164 & 332 438549 BE386801 Hs. 21858 trinucleotide repeat containing 3 Seq ID No 165 & 333 412580 AA113262 Hs. 17901 similar to CABLES [Homo sapiens] Seq ID No 166 & 334 417166 AA431323 Hs. 42146 Paired box protein Pax-3 Seq ID No 167 & 335 428513 BE220806 Hs. 184697 plexin C1 Seq ID No 168 & 336 447937 AL109716 Hs. 20034 HomosapiensmRNAhulilengthinsencDN SeqlDNo169&337 447937 AL109716 Hs. 20034 Homo sapiens mRNA full length insert cDN Seq ID No 170 & 338 446341 AL040763 Hs. 310735 FGENESHpredic60nsimilartomul6dnug SeqlDNo171&339 446341 AL040763 Hs. 310735 FGENESH prediction similar to multidrug Seq ID No 172 & 340 458079 A1796870 Hs. 54277 Homo sapiens similar to RIKEN cDNA 28100 Seq ID No 173 & 341 415668 AW957684 Hs. 306814 Homo sapiens lysyl oxidase-like 4 (LOXL4 Seq ID No 174 & 342 447674 BE270640 Hs. 19192 cyclin-dependent kinase 2 Seq ID No 175 & 343 447674 BE270640 Hs. 19192 cyclin-dependent kinase 2 Seq ID No 176 & 344 440065 W03476 Hs. 266331 Homo sapiens Fc receptor homolog express Seq ID No 177 & 345 414945 BE076358 Hs. 77667 lymphocyte antigen 6 complex, locus E Seq ID No 178 & 346 440672 AF083811 Hs. 7345 MAD1 (mitotic arrest deficient, yeast, h Seq ID No 179 & 347 412609 Z48804 Hs. 74124 ocular albinism 1 (Nettleship-Falls) Seq ID No 180 & 348 453837 AL138387 Hs. 256126 baculoviral IAP repeat-containing 7 (liv Seq ID No 181 & 349 453837 AL138387 Hs. 256126 baculoviral IAP repeat-containing 7 (liv Seq ID No 182 & 350 434276 AF123659 Hs. 93605 leucine zipper, putative tumor suppresso Seq ID No 183 & 351 408367 AK001178 Hs. 44424 Homosapiensorphanneurotransminertra SeqlDNo184&352 444809 BE207568 Hs. 208219 oculospanin Seq ID No 185 & 353 415929 AA724373 Hs. 304950 Homo sapiens mucolipin-3 (MCOLN3) Seq ID No 186 & 354 421666 AL035250 Hs. 1408 endothelin 3 Seq ID No 187 & 355

424321 W74048 Hs. 1765 lymphocyte-specific protein tyrosine kin Seq ID No 188 & 356 425535 AB007937 Hs. 158287 syndecan 3 Seq 10 No 189 & 357 451537 R56631 Hs. 26550 retinoid X receptor, gamma Seq ID No 190 & 358 430280 AA361258 Hs. 237868 interleukin 7 receptor Seq ID No 191 & 359 418064 BE387287 Hs. 83384 S100 calcium-binding protein, beta (neur Seq ID No 192 & 360 448610 NM 006157 Hs. 21602 nel (chicken)-like t Seq ID No 193 8 361 432800 BE391046 Hs. 278962 AIM-1 protein Seq ID No 194 & 362 416350 AF188625 Hs. 189507 phosphoiipaseA2, gnoupllD SeqiDNo195&363 405545 Target Exon Seq ID No 196 & 364 414812 X72755 Hs. 77367 monokine induced by gamma interferon Seq IO No 197 & 365 432874 W94322 Hs. 279651 melanoma inhibitory activity Seq ID No 198 & 366 Table 68 lists sequences as described in Table 67 Seq ID NO : 1 DNA sequence Nucleic Acid Accession # : NM 002421. 2 Coding sequence : 1.. 1409 1 11 21 31 41 51 ATGCACAGCT TTCCTCCACT GCTGCTGCTG CTGTTCTGGG GTGTGGTGTC ACACAGCTTC 60 CCAGCGACTC TAGAAACACA AGAGCAAGAT GTGGACTTAG TCCAGAAATA CCTGGAAAAA 120 TACTACAACC TGAAGAATGA TGGGAGGCAA GTTGAAAAGC GGAGAAATAG TGGCCCAGTG 180 GTTGAAAAAT TGAAGCAAAT GCAGGAATTC TTTGGGCTGA AAGTGACTGG GAAACCAGAT 240 GCTGAAACCC TGAAGGTGAT GAAGCAGCCC AGATGTGGAG TGCCTGATGT GGCTCAGTTT 300 GTCCTCACTG AGGGGAACCC TCGCTGGGAG CAAACACATC TGACCTACAG GATTGAAAAT 360 TACACGCCAG ATTTGCCAAG AGCAGATGTG GACCATGCCA TTGAGAAAGC CTTCCAACTC 420 TGGAGTAATG TCACACCTCT GACATTCACC AAGGTCTCTG AGGGTCAAGC AGACATCATG 480 ATATCTTTTG TCAGGGGAGA TCATCGGGAC AACTCTCCTT TTGATGGACC TGGAGGAAAT 540 CTTGCTCATG CTTTTCAACC AGGCCCAGGT ATTGGAGGGG ATGCTCATTT TGATGAAGAT 600 GAAAGGTGGA CCAACAATTT CAGAGAGTAC AACTTACATC GTGTTGCGGC TCATGAACTC 660 GGCCATTCTC TTGGACTCTC CCATTCTACT GATATCGGGG CTTTGATGTA CCCTAGCTAC 720 ACCTTCAGTG GTGATGTTCA GCTAGCTCAG GATGACATTG ATGGCATCCA AGCCATATAT 780 GGACGTTCCC AAAATCCTGT CCAGCCCATC GGCCCACAAA CCCCAAAAGC ATGTGACAGT 840 AAGCTAACCT TTGATGCTAT AACTACGATT CGGGGAGAAG TGATGTTCTT TAAAGACAGA 900 TTCTACATGC GCACAAATCC CTTCTACCCG GAAGTTGAGC TCAATTTCAT TTCTGTTTTC 960 TGGCCACAAC TGCCAAATGG GCTTGAAGCT GCTTACGAAT TTGCCGACAG AGATGAAGTC 1020 CGGTTTTTCA AAGGGAATAA GTACTGGGCT GTTCAGGGAC AGAATGTGCT ACACGGATAC 1080 CCCAAGGACA TCTACAGCTC CTTTGGCTTC CCTAGAACTG TGAAGCATAT CGATGCTGCT 1140 CTTTCTGAGG AAAACACTGG AAAAACCTAC TTCTTTGTTG CTAACAAATA CTGGAGGTAT 1200 GATGAATATA AACGATCTAT GGATCCAGGT TATCCCAAAA TGATAGCACA TGACTTTCCT 1260 GGAATTGGCC ACAAAGTTGA TGCAGTTTTC ATGAAAGATG GATTTTTCTA TTTCTTTCAT 1320 GGAACAAGAC AATACAAATT TGATCCTAAA ACGAAGAGAA TTTTGACTCT CCAGAAAGCT 1380 AATAGCTGGT TCAACTGCAG GAAAAATTAG Seq ID NO : 2 DNA sequence Nucleic Acid Accession # : NM_ 002421 2 Coding sequence : 1.. 1409 1 11 21 31 41 51 ATGCACAGCT TTCCTCCACT GCTGCTGCTG CTGTTCTGGG GTGTGGTGTC ACACAGCTTC 60 CCAGCGACTC TAGAAACACA AGAGCAAGAT GTGGACTTAG TCCAGAAATA CCTGGAAAAA 120 TACTACAACC TGAAGAATGA TGGGAGGCAA GTTGAAAAGC GGAGAAATAG TGGCCCAGTG 180 GTTGAAAAAT TGAAGCAAAT GCAGGAATTC TTTGGGCTGA AAGTGACTGG GAAACCAGAT 240 GCTGAAACCC TGAAGGTGAT GAAGCAGCCC AGATGTGGAG TGCCTGATGT GGCTCAGTTT 300 GTCCTCACTG AGGGGAACCC TCGCTGGGAG CAAACACATC TGACCTACAG GATTGAAAAT 360 TACACGCCAG ATTTGCCAAG AGCAGATGTG GACCATGCCA TTGAGAAAGC CTTCCAACTC 420 TGGAGTAATG TCACACCTCT GACATTCACC AAGGTCTCTG AGGGTCAAGC AGACATCATG 480 ATATCTTTTG TCAGGGGAGA TCATCGGGAC AACTCTCCTT TTGATGGACC TGGAGGAAAT 540 CTTGCTCATG CTTTTCAACC AGGCCCAGGT ATTGGAGGGG ATGCTCATTT TGATGAAGAT 600 GAAAGGTGGA CCAACAATTT CAGAGAGTAC AACTTACATC GTGTTGCGGC TCATGCCCTC 660 GGCCATTCTC TTGGACTCTC CCATTCTACT GATATCGGGG CTTTGATGTA CCCTAGCTAC 720 ACCTTCAGTG GTGATGTTCA GCTAGCTCAG GATGACATTG ATGGCATCCA AGCCATATAT 780 GGACGTTCCC AAAATCCTGT CCAGCCCATC GGCCCACAAA CCCCAAAAGC ATGTGACAGT 840 AAGCTAACCT TTGATGCTAT AACTACGATT CGGGGAGAAG TGATGTTCTT TAAAGACAGA 900 TTCTACATGC GCACAAATCC CTTCTACCCG GAAGTTGAGC TCAATTTCAT TTCTGTTTTC 960 TGGCCACAAC TGCCAAATGG GCTTGAAGCT GCTTACGAAT TTGCCGACAG AGATGAAGTC 1020 CGGTTTTTCA AAGGGAATAA GTACTGGGCT GTTCAGGGAC AGAATGTGCT ACACGGATAC 1080 CCCAAGGACA TCTACAGCTC CTTTGGCTTC CCTAGAACTG TGAAGCATAT CGATGCTGCT 1140 CTTTCTGAGG AAAACACTGG AAAAACCTAC TTCTTTGTTG CTAACAAATA CTGGAGGTAT 1200 GATGAATATA AACGATCTAT GGATCCAGGT TATCCCAAAA TGATAGCACA TGACTTTCCT 1260 GGAATTGGCC ACAAAGTTGA TGCAGTTTTC ATGAAAGATG GATTTTTCTA TTTCTTTCAT 1320 GGAACAAGAC AATACAAATT TGATCCTAAA ACGAAGAGAA TTTTGACTCT CCAGAAAGCT 1380 AATAGCTGGT TCAACTGCAG GAAAAATTAG Seq ID NO : 3 DNA sequence Nucleic Acid Accession # : NM_002422. 2 Coding sequence : 64.. 1497 1 11 21 31 41 51 ACAAGGAGGC AGGCAAGACA GCAAGGCATA GAGACAACAT AGAGCTAAGT AAAGCCAGTG 60 GAAATGAAGA GTCTTCCAAT CCTACTGTTG CTGTGCGTGG CAGTTTGCTC AGCCTATCCA 120 TTGGATGGAG CTGCAAGGGG TGAGGACACC AGCATGAACC TTGTTCAGAA ATATCTAGAA 180 AACTACTACG ACCTCAAAAA AGATGTGAAA CAGTTTGTTA GGAGAAAGGA CAGTGGTCCT 240

GTTGTTAAAA AAATCCGAGA AATGCAGAAG TTCCTTGGAT TGGAGGTGAC GGGGAAGCTG 300 GACTCCGACA CTCTGGAGGT GATGCGCAAG CCCAGGTGTG GAGTTCCTGA TGTTGGTCAC 360 TTCAGAACCT TTCCTGGCAT CCCGAAGTGG AGGAAAACCC ACCTTACATA CAGGATTGTG 420 AATTATACAC CAGATTTGCC AAAAGATGCT GTTGATTCTG CTGTTGAGAA AGCTCTGAAA 480 GTCTGGGAAG AGGTGACTCC ACTCACATTC TCCAGGCTGT ATGAAGGAGA GGCTGATATA 540 ATGATCTCTT TTGCAGTTAG AGAACATGGA GACTTTTACC CTTTTGATGG ACCTGGAAAT 600 GTTTTGGCCC ATGCCTATGC CCCTGGGCCA GGGATTAATG GAGATGCCCA CTTTGATGAT 660 GATGAACAAT GGACAAAGGA TACAACAGGG ACCAATTTAT TTCTCGTTGC TGCTCATGAA 720 ATTGGCCACT CCCTGGGTCT CTTTCACTCA GCCAACACTG AAGCTTTGAT GTACCCACTC 780 TATCACTCAC TCACAGACCT GACTCGGTTC CGCCTGTCTC AAGATGATAT AAATGGCATT 840 CAGTCCCTCT ATGGACCTCC CCCTGACTCC CCTGAGACCC CCCTGGTACC CACGGAACCT 900 GTCCCTCCAG AACCTGGGAC GCCAGCCAAC TGTGATCCTG CTTTGTCCTT TGATGCTGTC 960 AGCACTCTGA GGGGAGAAAT CCTGATCTTT AAAGACAGGC ACTTTTGGCG CAAATCCCTC 1020 AGGAAGCTTG AACCTGAATT GCATTTGATC TCTTCATTTT GGCCATCTCT TCCTTCAGGC 1080 GTGGATGCCG CATATGAAGT TACTAGCAAG GACCTCGTTT TCATTTTTAA AGGAAATCAA 1140 TTCTGGGCCA TCAGAGGAAA TGAGGTACGA GCTGGATACC CAAGAGGCAT CCACACCCTA 1200 GGTTTCCCTC CAACCGTGAG GAAAATCGAT GCAGCCATTT CTGATAAGGA AAAGAACAAA 1260 ACATATTTCT TTGTAGAGGA CAAATACTGG AGATTTGATG AGAAGAGAAA TTCCATGGAG 1320 CCAGGCTTTC CCAAGCAAAT AGCTGAAGAC TTTCCAGGGA TTGACTCAAA GATTGATGCT 1380 GTTTTTGAAG AATTTGGGTT CTTTTATTTC TTTACTGGAT CTTCACAGTT GGAGTTTGAC 1440 CCAAATGCAA AGAAAGTGAC ACACACTTTG AAGAGTAACA GCTGGCTTAA TTGTTGAAAG 1500 AGATATGTAG AAGGCACAAT ATGGGCACTT TAAATGAAGC TAATAATTCT TCACCTAAGT 1560 CTCTGTGAAT TGAAATGTTC GTTTTCTCCT GCCTGTGCTG TGACTCGAGT CACACTCAAG 1620 GGAACTTGAG CGTGAATCTG TATCTTGCCG GTCATTTTTA TGTTATTACA GGGCATTCAA 1680 ATGGGCTGCT GCTTAGCTTG CACCTTGTCA CATAGAGTGA TCTTTCCCAA GAGAAGGGGA 1740 AGCACTCGTG TGCAACAGAC AAGTGACTGT ATCTGTGTAG ACTATTTGCT TATTTAATAA 1800 AGACGATTTG TCAGTTGTTT T Seq ID NO : 4 DNA Sequence Nucleic Acid Accession # : NM001854 Coding sequence : 162.. 5582 1 11 21 31 41 51 AACCATCAAA TTTAGAAGAA AAAGCCCTTT GACTTTTTCC CCCTCTCCCT CCCCAATGGC 60 TGTGTAGCAA ACATCCCTGG CGATACCTTG GAAAGGACGA AGTTGGTCTG CAGTCGCAAT 120 TTCGTGGGTT GAGTTCACAG TTGTGAGTGC GGGGCTCGGA GATGGAGCCG TGGTCCTCTA 180 GGTGGAAAAC GAAACGGTGG CTCTGGGATT TCACCGTAAC AACCCTCGCA TTGACCTTCC 240 TCTTCCAAGC TAGAGAGGTC AGAGGAGCTG CTCCAGTTGA TGTACTAAAA GCACTAGATT 300 TTCACAATTC TCCAGAGGGA ATATCAAAAA CAACGGGATT TTGCACAAAC AGAAAGAATT 360 CTAAAGGCTC AGATACTGCT TACAGAGTTT CAAAGCAAGC ACAACTCAGT GCCCCAACAA 420 AACAGTTATT TCCAGGTGGA ACTTTCCCAG AAGACTTTTC AATACTATTT ACAGTAAAAC 480 CAAAAAAAGG AATTCAGTCT TTCCTTTTAT CTATATATAA TGAGCATGGT ATTCAGCAAA 540 TTGGTGTTGA GGTTGGGAGA TCACCTGTTT TTCTGTTTGA AGACCACACT GGAAAACCTG 600 CCCCAGAAGA CTATCCCCTC TTCAGAACTG TTAACATCGC TGACGGGAAG TGGCATCGGG 660 TAGCAATCAG CGTGGAGAAG AAAACTGTGA CAATGATTGT TGATTGTAAG AAGAAAACCA 720 CGAAACCACT TGATAGAAGT GAGAGAGCAA TTGTTGATAC CAATGGAATC ACGGTTTTTG 780 GAACAAGGAT TTTGGATGAA GAAGTTTTTG AGGGGGACAT TCAGCAGTTT TTGATCACAG 840 GTGATCCCAA GGCAGCATAT GACTACTGTG AGCATTATAG TCCAGACTGT GACTCTTCAG 900 CACCCAAGGC TGCTCAAGCT CAGGAACCTC AGATAGATGA GTATGCACCA GAGGATATAA 960 TCGAATATGA CTATGAGTAT GGGGAAGCAG AGTATAAAGA GGCTGAAAGT GTAACAGAGG 1020 GACCCACTGT AACTGAGGAG ACAATAGCAC AGACGGAGGC AAACATCGTT GATGATTTTC 1080 AAGAATACAA CTATGGAACA ATGGAAAGTT ACCAGACAGA AGCTCCTAGG CATGTTTCTG 1140 GGACAAATGA GCCAAATCCA GTTGAAGAAA TATTTACTGA AGAATATCTA ACGGGAGAGG 1200 ATTATGATTC CCAGAGGAAA AATTCTGAGG ATACACTATA TGAAAACAAA GAAATAGACG 1260 GCAGGGATTC TGATCTTCTG GTAGATGGAG ATTTAGGCGA ATATGATTTT TATGAATATA 1320 AAGAATATGA AGATAAACCA ACAAGCCCCC CTAATGAAGA ATTTGGTCCA GGTGTACCAG 1380 CAGAAACTGA TATTACAGAA ACAAGCATAA ATGGCCATGG TGCATATGGA GAGAAAGGAC 1440 AGAAAGGAGA ACCAGCAGTG GTTGAGCCTG GTATGCTTGT CGAAGGACCA CCAGGACCAG 1500 CAGGACCTGC AGGTATTATG GGTCCTCCAG GTCTACAAGG CCCCACTGGA CCCCCTGGTG 1560 ACCCTGGCGA TAGGGGCCCC CCAGGACGTC CTGGCTTACC AGGGGCTGAT GGTCTACCTG 1620 GTCCTCCTGG TACTATGTTG ATGTTACCGT TCCGTTATGG TGGTGATGGT TCCAAAGGAC 1680 CAACCATCTC TGCTCAGGAA GCTCAGGCTC AAGCTATTCT TCAGCAGGCT CGGATTGCTC 1740 TGAGAGGCCC ACCTGGCCCA ATGGGTCTAA CTGGAAGACC AGGTCCTGTG GGGGGGCCTG 1800 GTTCATCTGG GGCCAAAGGT GAGAGTGGTG ATCCAGGTCC TCAGGGCCCT CGAGGCGTCC 1860 AGGGTCCCCC TGGTCCAACG GGAAAACCTG GAAAAAGGGG TCGTCCAGGT GCAGATGGAG 1920 GAAGAGGAAT GCCAGGAGAA CCTGGGGCAA AGGGAGATCG AGGGTTTGAT GGACTTCCGG 1980 GTCTGCCAGG TGACAAAGGT CACAGGGGTG AACGAGGTCC TCAAGGTCCT CCAGGTCCTC 2040 CTGGTGATGA TGGAATGAGG GGAGAAGATG GAGAAATTGG ACCAAGAGGT CTTCCAGGTG 2100 AAGCTGGCCC ACGAGGTTTG CTGGGTCCAA GGGGAACTCC AGGAGCTCCA GGGCAGCCTG 2160 GTATGGCAGG TGTAGATGGC CCCCCAGGAC CAAAAGGGAA CATGGGTCCC CAAGGGGAGC 2220 CTGGGCCTCC AGGTCAACAA GGGAATCCAG GACCTCAGGG TCTTCCTGGT CCACAAGGTC 2280 CAATTGGTCC TCCTGGTGAA AAAGGACCAC AAGGAAAACC AGGACTTGCT GGACTTCCTG 2340 GTGCTGATGG GCCTCCTGGT CATCCTGGGA AAGAAGGCCA GTCTGGAGAA AAGGGGGCTC 2400 TGGGTCCCCC TGGTCCACAA GGTCCTATTG GATNNCCGGG CCCCCGGGGA GTAAAGGGAG 2460 CAGATGGTGT CAGAGGTCTC AAGGGATCTA AAGGTGAAAA GGGTGAAGAT GGTTTTCCAG 2520 GATTCAAAGG TGACATGGGT CTAAAAGGTG ACAGAGGAGA AGTTGGTCAA ATTGGCCCAA 2580 GAGGGNAAGA TGGCCCTGAA GGACCCAAAG GTCGAGCAGG CCCAACTGGA GACCCAGGTC 2640 CTTCAGGTCA AGCAGGAGAA AAGGGAAAAC TTGGAGTTCC AGGATTACCA GGATATCCAG 2700 GAAGACAAGG TCCAAAGGGT TCCACTGGAT TCCCTGGGTT TCCAGGTGCC AATGGAGAGA 2760 AAGGTGCACG GGGAGTAGCT GGCAAACCAG GCCCTCGGGG TCAGCGTGGT CCAACGGGTC 2820 CTCGAGGTTC AAGAGGTGCA AGAGGTCCCA CTGGGAAACC TGGGCCAAAG GGCACTTCAG 2880 GTGGCGATGG CCCTCCTGGC CCTCCAGGTG AAAGAGGTCC TCAAGGACCT CAGGGTCCAG 2940 TTGGATTCCC TGGACCAAAA GGCCCTCCTG GACCACCAGG AAGGATGGGC TGCCCAGGAC 3000 ACCCTGGGCA ACGTGGGGAG ACTGGATTTC AAGGCAAGAC CGGCCCTCCT GGGCCAGGGG 3060

GAGTGGTTGG ACCACAGGGA CCAACCGGTG AGACTGGTCC AATAGGGGAA CGTGGGTATC 3120 CTGGTCCTCC TGGCCCTCCT GGTGAGCAAG GTCTTCCTGG TGCTGCAGGA AAAGAAGGTG 3180 CAAAGGGTGA TCCAGGTCCT CAAGGTATCT CAGGGAAAGA TGGACCAGCA GGATTACGTG 3240 GTTTCCCAGG GGAAAGAGGT CTTCCTGGAG CTCAGGGTGC ACCTGGACTG AAAGGAGGGG 3300 AAGGTCCCCA GGGCCCACCA GGTCCAGTTG GCTCACCAGG AGAACGTGGG TCAGCAGGTA 3360 CAGCTGGCCC AATTGGTTTA CGAGGGCGCC CGGGACCTCA GGGTCCTCCT GGTCCAGCTG 3420 GAGAGAAAGG TGCTCCTGGA GAAAAAGGTC CCCAAGGGCC TGCAGGGAGA GATGGAGTTC 3480 AAGGTCCTGT TGGTCTCCCA GGGCCAGCTG GTCCTGCCGG CTCCCCTGGG GAAGACGGAG 3540 ACAAGGGTGA AATTGGTGAG CCGGGACAAA AAGGCAGCAA GGGTGGCAAG GGAGAAAATG 3600 GCCCTCCCGG TCCCCCAGGT CTTCAAGGAC CAGTTGGTGC CCCTGGAATT GCTGGAGGTG 3660 ATGGTGAACC AGGTCCTAGA GGACAGCAGG GGATGTTTGG GCAAAAAGGT GATGAGGGTG 3720 CCAGAGGCTT CCCTGGACCT CCTGGTCCAA TAGGTCTTCA GGGTCTGCCA GGCCCACCTG 3780 GTGAAAAAGG TGAAAATGGG GATGTTGGTC CATGGGGGCC ACCTGGTCCT CCAGGCCCAA 3840 GAGGCCCTCA AGGTCCCAAT GGAGCTGATG GACCACAAGG ACCCCCAGGT TCTGTTGGTT 3900 CAGTTGGTGG TGTTGGAGAA AAGGGTGAAC CTGGAGAAGC AGGAAACCCA GGGCCTCCTG 3960 GGGAAGCAGG TGTAGGCGGT CCCAAAGGAG AAAGAGGAGA GAAAGGGGAA GCTGGTCCAC 4020 CTGGAGCTGC TGGACCTCCA GGTGCCAAGG GGCCGCCAGG TGATGATGGC CCTAAGGGTA 4080 ACCCGGGTCC TGTTGGTTTT CCTGGAGATC CTGGTCCTCC TGGGGAACTT GGCCCTGCAG 4140 GTCAAGATGG TGTTGGTGGT GACAAGGGTG AAGATGGAGA TCCTGGTCAA CCGGGTCCTC 4200 CTGGCCCATC TGGTGAGGCT GGCCCACCAG GTCCTCCTGG AAAACGAGGT CCTCCTGGAG 4260 CTGCAGGTGC AGAGGGAAGA CAAGGTGAAA AAGGTGCTAA GGGGGAAGCA GGTGCAGAAG 4320 GTCCTCCTGG AAAAACCGGC CCAGTCGGTC CTCAGGGACC TGCAGGAAAG CCTGGTCCAG 4380 AAGGTCTTCG GGGCATCCCT GGTCCTGTGG GAGAACAAGG TCTCCCTGGA GCTGCAGGCC 4440 AAGATGGACC ACCTGGTCCT ATGGGACCTC CTGGCTTACC TGGTCTCAAA GGTGACCCTG 4500 GCTCCAAGGG TGAAAAGGGA CATCCTGGTT TAATTGGCCT GATTGGTCCT CCAGGAGAAC 4560 AAGGGGAAAA AGGTGACCGA GGGCTCCCTG GAACTCAAGG ATCTCCAGGA GCAAAAGGGG 4620 ATGGGGGAAT TCCTGGTCCT GCTGGTCCCT TAGGTCCACC TGGTCCTCCA GGCTTACCAG 4680 GTCCTCAAGG CCCAAAGGGT AACAAAGGCT CTACTGGACC CGCTGGCCAG AAAGGTGACA 4740 GTGGTCTTCC AGGGCCTCCT GGGCCTCCAG GTCCACCTGG TGAAGTCATT CAGCCTTTAC 4800 CAATCTTGTC CTCCAAAAAA ACGAGAAGAC ATACTGAAGG CATGCAAGCA GATGCAGATG 4860 ATAATATTCT TGATTACTCG GATGGAATGG AAGAAATATT TGGTTCCCTC AATTCCCTGA 4920 AACAAGACAT CGAGCATATG AAATTTCCAA TGGGTACTCA GACCAATCCA GCCCGAACTT 4980 GTAAAGACCT GCAACTCAGC CATCCTGACT TCCCAGATGG TGAATATTGG ATTGATCCTA 5040 ACCAAGGTTG CTCAGGAGAT TCCTTCAAAG TTTACTGTAA TTTCACATCT GGTGGTGAGA 5100 CTTGCATTTA TCCAGACAAA AAATCTGAGG GAGTAAGAAT TTCATCATGG CCAAAGGAGA 5160 AACCAGGAAG TTGGTTTAGT GAATTTAAGA GGGGAAAACT GCTTTCATAC TTAGATGTTG 5220 AAGGAAATTC CATCAATATG GTGCAAATGA CATTCCTGAA ACTTCTGACT GCCTCTGCTC 5280 GGCAAAATTT CACCTACCAC TGTCATCAGT CAGCAGCCTG GTATGATGTG TCATCAGGAA 5340 GTTATGACAA AGCACTTCGC TTCCTGGGAT CAAATGATGA GGAGATGTCC TATGACAATA 5400 ATCCTTTTAT CAAAACACTG TATGATGGTT GTACGTCCAG AAAAGGCTAT GAAAAAACTG 5460 TCATTGAAAT CAATACACCA AAAATTGATC AAGTACCTAT TGTTGATGTC ATGATCAGTG 5520 ACTTTGGTGA TCAGAATCAG AAGTTCGGAT TTGAAGTTGG TCCTGTTTGT TTTCTTGGCT 5580 AAGATTAAGA CAAAGAACAT ATCAAATCAA CAGAAAATGT ACCTTGGTGC CACCAACCCA 5640 TTTTGTGCCA CATGCAAGTT TTGAATAAGG ATGTATGGAA AACAACGCTG CATATACAGG 5700 TACCATTTAG GAAATACCGA TGCCTTTGTG GGGGCAGAAT CACAGACAAA AGCTTTGAAA 5760 ATCATAAAGA TATAAGTTGG TGTGGCTAAG ATGGAAACAG GGCTGATTCT TGATTCCCAA 5820 TTCTCAACTC TCCTTTTCCT ATTTGAATTT CTTTGGTGCT GTAGAAAACA AAAAAAGAAA 5880 AATATATATT CATAAAAAAT ATGGTGCTCA TTCTCATCCA TCCAGGATGT ACTAAAACAG 5940 TGTGTTTAAT AAATTGTAAT TATTTTGTGT ACAGTTCTAT ACTGTTATCT GTGTCCATTT 6000 CCAAAACTTG CACGTGTCCC TGAATTCCGC TGACTCTAAT TTATGAGGAT GCCGAACTCT 6060 GATGGCAATA ATATATGTAT TATGAAAATG AAGTTATGAT TTCCGATGAC CCTAAGTCCC 6120 TTTCTTTGGT TAATGATGAA ATTCCTTTGT GTGTGTTT Seq ID NO : 5 DNA sequence Nucleic Acid Accession # : XM057014 Coding sequence : 143.. 874 1 11 21 31 41 51 ( GGGAGGGAGA GAGGCGCGCG GGTGAAAGGC GCATTGATGC AGCCTGCGGC GGCCTCGGAG 60 CGCGGCGGAG CCAGACGCTG ACCACGTTCC TCTCCTCGGT CTCCTCCGCC TCCAGCTCCG 120 CGCTGCCCGG CAGCCGGGAG CCATGCGACC CCAGGGCCCC GCCGCCTCCC CGCAGCGGCT 180 CCGCGGCCTC CTGCTGCTCC TGCTGCTGCA GCTGCCCGCG CCGTCGAGCG CCTCTGAGAT 240 CCCCAAGGGG AAGCAAAAGG CGCAGCTCCG GCAGAGGGAG GTGGTGGACC TGTATAATGG 300 AATGTGCTTA CAAGGGCCAG CAGGAGTGCC TGGTCGAGAC GGGAGCCCTG GGGCCAATGG 360 CATTCCGGGT ACACCTGGGA TCCCAGGTCG GGATGGATTC AAAGGAGAAA AGGGGGAATG 420 TCTGAGGGAA AGCTTTGAGG AGTCCTGGAC ACCCAACTAC AAGCAGTGTT CATGGAGTTC 480 ATTGAATTAT GGCATAGATC TTGGGAAAAT TGCGGAGTGT ACATTTACAA AGATGCGTTC 540 AAATAGTGCT CTAAGAGTTT TGTTCAGTGG CTCACTTCGG CTAAAATGCA GAAATGCATG 600 CTGTCAGCGT TGGTATTTCA CATTCAATGG AGCTGAATGT TCAGGACCTC TTCCCATTGA 660 AGCTATAATT TATTTGGACC AAGGAAGCCC TGAAATGAAT TCAACAATTA ATATTCATCG 720 CACTTCTTCT GTGGAAGGAC TTTGTGAAGG AATTGGTGCT GGATTAGTGG ATGTTGCTAT 780 CTGGGTTGGC ACTTGTTCAG ATTACCCAAA AGGAGATGCT TCTACTGGAT GGAATTCAGT 840 TTCTCGCATC ATTATTGAAG AACTACCAAA ATAAATGCTT TAATTTTCAT TTGCTACCTC 900 TTTTTTTATT ATGCCTTGGA ATGGTTCACT TAAATGACAT TTTAAATAAG TTTATGTATA 960 CATCTGAATG AAAAGCAAAG CTAAATATGT TTACAGACCA AAGTGTGATT TCACACTGTT 1020 TTTAAATCTA GCATTATTCA TTTTGCTTCA ATCAAAAGTG GTTTCAATAT TTTTTTTAGT 1080 TGGTTAGAAT ACTTTCTTCA TAGTCACATT CTCTCAACCT ATAATTTGGA ATATTGTTGT 1140 GGTCTTTTGT TTTTTCTCTT AGTATAGCAT TTTTAAAAAA ATATAAAAGC TACCAATCTT 1200 TGTACAATTT GTAAATGTTA AGAATTTTTT TTATATCTGT TAAATAAAAA TTATTTCCAA 1260 CAACCTTAAA AAAAAAAAAA AAAA Seq ID NO : 6 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51

I I I I I I CAGGCCGGAC CACTTGCTAT ATGTAGGCNN NNNNNNNNNN NNNNAAATAC ACTTACTGTG 60 TTCTAGAGGC AGCCCTTTCT TATGCAGAAA ATACAATACG CACTGCATGA GAAGCTTGAG 120 AGTGGATTCT AATCCAGGTC TGTCGACCTT GGATATCATG CATGTGGGAA GGTGGGTGTG 180 GTGAGAAAAG TTTTAAGGCA AGAGTAGATG GCCATGTTCA ACTTTACAAA ATTTCTTGGA 240 AAACTGGCAG TATTTTGAAC TGCATCTTCT TTGGTACCGG AACCTGCAGA AACAGTGTGA 300 GAAATTAAGT CCTGGTTCAC TGCGCAGTAG CAAAGATGGT CAAGGCCATG GAAAAAGCAG 360 AAATTTACCA AGAAAGCTGA TACCCATGTA TAGTTCCCAC TCATCTCAAA TACATCTGCT 420 ATCTTTTTAA GCTAAGTCCT AGACATATCG GGGATAACAT GGGGGTTGAT TAGTGACCAC 480 AGTTATCAGA AGCAGAGAAA TGTAATTCCA TATTTTATTT GAAACTTATT CCATATTTTA 540 ATTGGATATT GAGTGATTGG GTTATCAAAC ACCCACAAAC TTTAATTTTG TTAAATTTAT 600 ATGGCTTTGA AATAGAAGTA TAAGTTGCTA CCATTTTTTG ATAACATTGA AAGATAGTAT 660 TTTACCATCT TTAATCATCT TGGAAAATAC AAGTCCTGTG AACAACCACT CTTTCACCTA 720 GCAGCATGAG GCCAAAAGTA AAGGCTTTAA ATTATAACAT ATGGGATTCT TAGTAGTATG 780 TTTTTTTCTT GAAACTCAGT GGCTCTATCN AACCTTACTA TCTCCTCACT CTTTCTCTAA 840 GACTAAACTC TAGGCTCTTA AAAATCTGCC CACACCAATC TTAGAAGCTC TGAAAAGAAT 900 TTGTCTTTAA ATATCTTTTA ATAGTAACAT GTATTTTATG GACCAAATTG ACATTTTCGA 960 CTATTTTTTC CAAAAAAGTC AGGTGAATTT CAGCACACTG AGTTGGGAAT TTCTTATCCC 1020 AGAAGACCAA CCAATTTCAT ATTTATTTAA GATTGATTCC ATACTCCGTT TTCAAGGAGA 1080 ATCCCTGCAG TCTCCTTAAA GGTAGAACAA ATACTTTCTA TTTTTTTTTT CACCATTGTG 1140 GGATTGGACT TTAAGAGGTG ACTCTAAAAA AACAGAGAAC AAATATGTCT CAGTTGTATT 1200 AAGCACGGAC CCATATTATC ATATTCACTT AAAAAAATGA TTTCCTGTGC ACCTTTTGGC 1260 AACTTCTCTT TTCAATGTAG GGAAAAACTT AGTCACCCTG AAAACCCACA AAATAAATAA 1320 AACTTGTAGA TGTGGGCAGA AGGTTTGGGG GTGGACATTG TATGTGTTTA AATTAAACCC 1380 TGTATCACTG AGAAGCTGTT GTATGGGTCA GAGAAAATGA ATGCTTAGAA GCTGTTCACA 1440 TCTTCAAGAG CAGAAGCAAA CCACATGTCT CAGCTATATT ATTATTTATT TTTTATGCAT 1500 AAAGTGAATC ATTTCTTCTG TATTAATTTC CAAAGGGTTT TACCCTCTAT TTAAATGCTT 1560 TGAAAAACAG TGCATTGACA ATGGGTTGAT ATTTTTCTTT AAAAGAAAAA TATAATTATG 1620 AAAGCCAAGA TAATCTGAAG CCTGTTTTAT TTTAAAACTT TTTATGTTCT GTGGTTGATG 1680 TTGTTTGTTT GTTTGTTTCT ATTTTGTTGG TTTTTTACTT TGTTTTTTGT TTTGTTTTGT 1740 TTTGTTTTGC ATACTACATG CAGTTCTTTA ACCAATGTCT GTTTGGCTAA TGTAATTAAA 1800 GTTGTTAATT TATATGAGTG CATTTCAACT ATGTCAATGG TTTCTTAATA TTTATTGTGT 1860 AGAAGTACTG GTAATTTTTT TATTTACAAT ATGTTTAAAG AGATAACAGT TTGATATGTT 1920 TTCATGTGTT TATAGCAGAA GTTATTTATT TCTATGGCAT TCCAGCGGAT ATTTTGGTGT 1980 TTGCGAGGCA TGCAGTCAAT ATTTTGTACA GTTAGTGGCC AGTATTCAGC AACGCCTGAT 2040 AGCTTCTTTG GCCTTATGTT AAATAAAAAG ACCTGTTTGG GATGTAAAAA AAAAAAAAAA 2100 AAAAAAAAAA GGAGAGCGAG GACGGGCAAA AACAGCAGAG AGGAGAAAGG AAGAGCAACA 2160 GAAAGAGAGA ACGAGAGAGG AGGAGCAGGC CAGCGAGGCG GAGGAGAGGG AAGCAAGCAG 2220 CGGGCGCGCG GCGAAGACAG GGCGCGGCGC AGCAGCAGGA GAGGGGGGGA GGCGGGCGGG 2280 ACGGGAGGGG GGGACCCGAG AGGAGCGGGA AGAGGAGGGG CGGGCAGGAA GGGCCGCGGA 2340 GGAGGGGAGG AACGAAGCGA AGCGGGGAGG AGA 2373 Seq ID NO : 7 DNA sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 1.. 5001 1 11 21 31 41 51 ( ATGCCAGGCA CAAAACTAAC CCGAACAGGC GCCCCAGCAG ACTACAGAGT GATATTGAAG 60 ACCTCTCAAG AGGACGAATT GGATGTACCT GACGACATCA GCGTCCGGGT TATGTCATCT 120 CAGTCTGTGC TTGTGTCCTG GGTGGATCCT GTTCTGGAAA AACAGAAGAA AGTTGTTGCA 180 TCAAGACAGT ACACCGTGCG CTATCGAGAG AAGGGGGAAT TGGCCAGGTG GGATTATAAG 240 CAGATCGCTA ACAGGCGTGT GCTGATTGAG AACCTGATTC CAGACACTGT GTATGAATTT 300 GCAGTCCGTA TTTCACAGGG TGAAAGAGAT GGCAAATGGA GTACGTCAGT CTTCCAAAGA 360 ACACCAGAAT CTGCCCCTAC CACAGCTCCT GAAAACTTGA ACGTCTGGCC AGTCAATGGC 420 AAACCTACAG TTGTCGCTGC ATCTTGGGAT GCGCTACCAG AGACTGAGGG GAAAGTGAAA 480 GTCTGTCTGC TGGACACAGG ACTGTTTTCA GTTTCCTCCT TCCAACCATC TGCCAAATCA 540 TTTCAGAATA CATTCTTTCA TACGCCCCGG CTCTCAAACC ATTTGGAGCA AAGTCCCTCA 600 CCTATCCTGG AGACACTACT TCTGCCCTGG TGGATGGTCT GCAGCCTGGG GAACGCTATC 660 TTTTCAAAAT CCGGGCCACA AACAGGAGAG GCCTGGGACC TCACTCCAAA GCCTTCATTG 720 TCGCTATGCC AACAAGAATG CAGCTGTACC CAGAAGGATT TCAGTTGTCT AGCTTACCTG 780 ATCGATATCC AAACCAAACA AGTTAATAAA GATCCACAAC TGGAAGGGAG TGTTTTTGGA 840 CCATGTTTTC TTTTCTACTT CCTCACATTT ATGCTGGATA TTGGCGGCTT TTCCTTCATT 900 ATGTGCTATG AAGACCCANN TGTTTCTTCT TTGACAGGCA ATTCTTTAAA ATCTGTTGCA 960 GCCAGTAAGG CGGATGTTCA GCAGAACACG GAGGACAATG GGAAACCCGA AAAACCTGAG 1020 CCTTCCTCAC CTTCTCCCAG AGCTCCAGCT TCCTCCCAAC ACCCCTCTGT GCCTGCTTCT 1080 CCCCAAGGGA GAAATGCCAA GGACCTTCTT CTTGACTTGA AGAACAAAAT ATTGGCTAAT 1140 GGTGGGGCGC CCCGAAAACC CCAGCTTCGC GCCAAGAAGG CAGAGGAGCT GGATCTTCAG 1200 TCGACAGAAA TCACTGGGGA GGAGGAGCTG GGTTCCCGGG AGGACTCGCC CATGTCACCC 1260 TCAGACACCC AAGACCAGAA ACGGACCCTG AGGCCGCCAA GTAGACACGG CCACTCGGTG 1320 GTTGCTCCCG GCAGGACTGC AGTGAGGGCC CGGATGCCAG CGCTGCCCCG AAGGGAAGGC 1380 GTAGATAAGC CTGGCTTTTC CCTGGCCACG CAGCCCCGCC CAGGGGCGCC CCCCTCGGCT 1440 TCGGCCTCTC CTGCCCACCA CGCGTCCACC CAGGGCACCT CTCATCGTCC TTCCCTGCCT 1500 GCCAGCTTGA ATGACAACGA CTTGGTGGAC TCAGACGAAG ATGAGCGCGC TGTGGGCTCC 1560 CTCCACCCCA AGGGCGCCTT CGCCCAGCCC CGGCCAGCCC TGTCCCCCAG CCGCCAGTCC 1620 CCGTCCAGCG TTCTCCGCGA CAGAAGCTCT GTGCACCCCG GCGCAAAGCC AGCCTCGCCG 1680 GCGCGGAGGA CCCCCCATTC AGGGGCCGCA GAGGAAGATT CCAGTGCCTC AGCCCCACCC 1740 TCAAGACTTT CTCCACCCCA TGGGGGATCA TCTCGGCTGC TGCCCACCCA GCCACACCTG 1800 AGCTCTCCAC TTTCCAAGGG CGGGAAGGAT GGTGAGGACG CCCCAGCCAC CAACTCCAAT 1860 GCGCCATCAC GGTCCACCAT GTCCTCCTCC GTCTCTTCTC ATCTCTCGTC CAGGACGCAG 1920 GTCTCTGAGG GAGCGGAGGC TTCTGATGGT GAAAGCCACG GTGACGGCGA TAGGGAAGAC 1980 GGCGGAAGGC AGGCGGAGGC CACGGCCCAG ACGCTGCGGG CCCGGCCTGC CTCTGGACAC 2040 TTCCATTTGC TCAGACACAA ACCCTTTGCT GCCAACGGGA GGTCTCCAAG CAGGTTCAGC 2100 ATTGGGCGGG GACCTCGGCT GCAGCCCTCC AGCTCCCCAC AGTCGACTGT GCCCTCCCGA 2160 GCCCACCCCA GGGTTCCCTC TCACTCTGAT TCCCACCCTA AGCTTAGCTC AGGTATCCAT 2220

GGAGACGAGG AGGATGAGAA GCCGCTTCCT GCCACCGTTG TCAATGACCA CGTGCCTTCC 2280 TCCTCCAGGC AGCCCATCTC CCGGGGCTGG GAGGACTTAA GGAGAAGCCC GCAGAGAGGG 2340 GCCAGCCTGC ATCGGAAGGA ACCCATCCCA GAGAACCCCA AATCCACAGG GGCAGATACA 2400 CATCCTCAGG GCAAGTACTC CTCCCTGGCC TCCAAGGCTC AGGATGTTCA ACAGAGCACA 2460 GACGCGGACA CGGAGGGTCA TTCTCCCAAA GCACAGCCAG GGTCCACAGA CCGCCACGCG 2520 TCCCCTGCTC GTCCTCCCGC AGCACGGTCA CAGCAGCATC CCAGTGTTCC CAGAAGGATG 2580 ACACCCGGCC GGGCCCCAGA ACAGCAGCCC CCTCCTCCCG TCGCCACGTC CCAGCACCAC 2640 CCGGGACCCC AGAGCAGAGA CGCGGGTCGG TCACCTTCCC AGCCCAGGCT CTCACTGACC 2700 CAGGCCGGGC GGCCCCGCCC CACGTCGCAG GGCCGCTCCC ACTCCTCCTC GGACCCTTAC 2760 ACGGCGAGCT CCAGAGGGAT GCTCCCCACG GCCCTCCAGA ACCAGGACGA GGATGCCCAG 2820 GGCAGCTACG ACGACGACAG CACAGAAGTC GAGGCCCAGG ATGTGCGGGC CCCCGCGCAC 2880 GCCGCGCGCG CCAAGGAGGC AGCTGCGTCC CTTCCCAAGC ACCAGCAGGT GGAGTCTCCC 2940 ACAGGCGCAG GGGCAGGTGG CGACCACAGG TCCCAGCGCG GACATGCGGC CTCCCCCGCC 3000 AGGCCCAGCC GACCCGGCGG CCCCCAGTCC CGCGCCCGGG TCCCCAGCAG GGCAGCGCCG 3060 GGGAAGTCGG AGCCTCCTTC CAAGCGGCCC CTGTCCTCCA AGTCCCAGCA GTCGGTCTCA 3120 GCCGAGGACG AGGAGGAGGA GGACGCGGGG TTTTTTAAAG GCGGGAAAGA AGACCTTCTG 3180 TCTTCCTCTG TGCCAAAGTG GCCCTCTTCC TCCACTCCCA GGGGCGGCAA AGACGCCGAT 3240 GGGAGCCTCG CCAAGGAAGA GAGGGAGCCT GCCATCGCGC TTGCCCCTCG CGGAGGGAGC 3300 CTGGCTCCTG TGAAGCGACC TCTCCCCCCA CCTCCAGGCA GCTCCCCCAG GGCCTCCCAC 3360 GTCCCTTCCC GACCGCCGCC TCGCAGCGCT GCCACCGTGA GCCCCGTCGC GGGCACCCAC 3420 CCCTGGCCGC GGTACACCAC GCGCGCCCCV CCTGGCCACT TCTCCACCAC CCCGATGCTG 3480 TCCTTGCGCC AGAGGATGAT GCATGCCAGA TTCCGTAACC CTCTCTCCCG ACAGCCTGCC 3540 AGACCCTCTT ACAGACAAGG TTATAATGGC AGACCAAATG TAGAAGGGAA AGTCCTTCCT 3600 GGTAGTAATG GAAAACCGAA TGGACAGAGA ATTATCAATG GCCCTCAAGG AACAAAGTGG 3660 GTTGTGGACC TTGATCGTGG GTTAGTATTG AATGCAGAAG GAAGGTACCT CCAAGATTCA 3720 CATGGAAATC CTCTTCGGAT TAAACTAGGA GGAGATGGTC GAACCATTGT AGATCTGGAA 3780 GGGACCCCCG TGGTGAGTCC TGACGGCCTC CCACTCTTTG GGCAGGGGCG ACATGGCACA 3840 CCTCTGGCCA ATGCCCAAGA TAAGCCAATT TTGAGTCTTG GAGGAAAGCC GCTGGTGGGC 3900 TTGGAGGTCA TCAAAAAAAC CACCCATCCC CCTACCACTA CCATGCAGCC CACCACTACT 3960 ACGACGCCCC TGCCTACCAC TACAACCCCG AGGCCCACCA CTGCCACCAC CATGCAGCCC 4020 ACCACTACTA CGACGCCCCT GCCTACCACT ACACCGAGGC CCACCACTGC CACCACCCGC 4080 CGCACGACCA CCAGGCGTCC AACAACCACA GTCCGAACCA CTACGCGGAC AACCACCACC 4140 ACCACCCCCA AACCCACCAC TCCCATCCCC ACCTGTCCCC CTGGGACCTT GGAACGGCAC 4200 GACGATGATG GCAACCTGAT AATGAGCTCC AATGGGATCC CAGAGTGCTA CGCTGAAGAA 4260 GATGAGTTCT CAGGCTTGGA GACTGACACT GCAGTACCTA CGGAAGAGGC CTACGTTATA 4320 TATGATGAAG ATTATGAATT TGAGACGTCA AGGCCACCAA CCACCACTGA GCCTTCGACC 4380 ACTGCTACCA CACCGAGGGT GATCCCAGAG GAAGGCGCCA TCAGTTCCTT TCCTGAAGAA 4440 GAATTTGATC TGGCTGGAAG GAAACGATTT GTTGCTCCTT ACGTGACGTA CCTAAATAAA 4500 GACCCATCAG CCCCGTGCTC TCTGACTGAT GCACTGGATC ACTTCCAAGT GGACAGCCTG 4560 GATGAAATCA TCCCCAATGA CCTGAAGAAG AGTGATCTGC CTCCCCAGCA TGCTCCCCGC 4620 AACATCACCG TGGTGGCCGT GGAAGGTTGC CACTCATTTG TCATTGTGGA TTGGGACAAA 4680 GCCACCCCAG GAGATTTGGT CACAGGTTAT TTGGTTTACA GTGCATCCTA TGAAGATTTC 4740 ATCAGGAACA AGTTTTCCAC TCAAGCTTCA TCAGTAACTC ACTTGCCCAT TGAGAACCTA 4800 AAGCCCAACA CGAGGTATTA TTTTAAAGTG CAAGCACAAA ATCCTCATGG CTACGGACCT 4860 ATCAGCCCTT CGGTCTCATT TGTCACCGAA TCAGATAATC CTCTGCTTGT TGTGAGGCCC 4920 CCAGGCGGTG AGCTATCTGG ATCCCATTCG CTTTCAAACA TGATCCCAGC TACACGGACT 4980 GCCATGGACG GCAATATGTG AAGCGCACGT GGTATCGAAA GTTCGTGGGA GTTGTTCTTT 5040 GTAATTCACT GAGGTATAAA ATCTACCTCA GTGACAACCT GAAAGATACA TTCTACAGCA 5100 TTGGAGACAG CTGGGGAAGA GGTGAAGACC ATTGCCAATT TGTGGATTCA CACCTTGATG 5160 GAAGAACAGG GCCTCAGTCC TATGTAGAAG CCCTCCCTAC TATTCAAGGC TACTATCGCC 5220 AGTATCGTCA GGAGCCTGTC AGGTTTGGGA ACATCGGCTT CGGAACCCCC TACTACTATG 5280 TGGGCTGGTA CGAGTGTGGG GTCTCCATCC CTGGAAAGTG GTAATCACAG GACCGTCATG 5340 CTGCAAGCTT GCCCTGCCCA GCCCCACCAA CTAAGTCGCA CTAGGGGCTG TGAGCAAAGA 5400 CAGCCAGCAT GCTCAGCCCC GCTGCCCTAG GTGCCAGGAA GGTCACAGAT GGACACTGGC 5460 CATTCTGGTC ATCTCAGTCT GGAACTCAGT CCCACTTCTT GGCCTGGACA ATGAACAGGA 5520 TTCAGTTTTG CTGTTAACTT TGCTTCTCTA CTTTTTTTTG TTTGTTTGTA ATAGCACATC 5580 CCAGAGACAT CAGAAACCAG CAACTGATTC AGTGTGATTT CCCAGACTTT TTAGGCATGA 5640 AATTCGGACA CTTCAGTATT TCCAGGAATA GCATATGCAC GCTGTTCTTG CTTCATGGAA 5700 TGCTACATGC TTTCTGTTTT TCTCATTTTG GATTTCTCCA AAACTAACTG AATTTAAGCT 5760 TCAGGTCCCT TTGTATGCAG TAGAAAGGAA TTATTAAAAA CACCACCAAA GAAAATAAAT 5820 ATATCCTACT TGAAATTTAC TCTATGGACT TACCCACTGC TAGAATAAAT GTATCAAATC 5880 TTATTTGTAA ATTCTCAATT TTGATATATA TATGTATATA TGCATATACA TATCCACACT 5940 TGTCTGCAAG AATATTGATT AAAATTGCTA AATTTGTACT TGTTCACCAA AAAAAAAAAA 6000 AAAAAAA Seq ID NO : 8 DNA Sequence Nucleic Acid Accession # : Nom 014244 Coding sequence : 1.. 3636 1 11 21 31 41 51 ATGGATCCGC CGGCGGGAGC CGCTCGCCGC CTGCTCTGCC CCGCGCTGCT GCTGCTGCTG 60 CTGCTGCTGC CGCCGCCGCT CCTGCCGCCG CCGCCGCCGC CCGCGAACGC CAGGCTCGCC 120 GCCGCCGCCG ACCCCCCAGG CGGGCCCCTG GGGCACGGAG CGGAGCGCAT CCTGGCGGTG 180 CCCGTGCGCA CTGACGCCCA GGGCCGCTTG GTGTCCCACG TGGTGTCGGC AGCTACGTCC 240 AGAGCAGGGG TACGAGCCCG CAGGGCCGCC CCGGTCCGGA CCCCGAGCTT CCCCGGAGGC 300 AACGAGGAGG AGCCTGGCAG TCACCTCTTC TACAATGTCA CGGTCTTTGG CCGAGACCTG 360 CACCTGCGGC TGCGGCCCAA CGCCCGCCTC GTGGCGCCCG GGGCCACTAT GGAGTGGCAG 420 GGCGAGAAGG GCACCACCCG CGTGGAGCCC CTGCTCGGGA GCTGTCTCTA CGTCGGAGAC 480 GTGGCCGGCC TAGCCGAAGC CTCCTCTGTG GCGCTCAGCA ACTGCGATGG GCTGGCTGGT 540 CTGATCCGGA TGGAGGAGGA GGAGTTCTTC ATCGAACCCT TGGAGAAGGG GCTGGCGGCG 600 CAGGAGGCTG AGCAAGGCCG TGTGCATGTG GTGTATCGCC GGCCACCCAC GTCCCCTCCT 660 CTCGGGGGGC CACAGGCCCT GGACACAGGG GCCTCCCTGG ACAGCCTGGA CAGCCTCAGC 720 CGCGCCCTGG GCGTCCTAGA GGAGCACGCC AACAGCTCGA GGCGGAGGGC ACGCAGGCAT 780 GCTGCAGACG ATGACTACAA CATCGAGGTC CTGCTGGGCG TGGATGACTC TGTGGTGCAG 840

TTCCACGGGA AGGAGCACGT ACAGAAGTAC CTGCTGACAC TCATGAACAT TGTCAATGAA 900 ATCTACCATG ACGAGTCCTT GGGTGCCCAC ATCAACGTGG TCCTGGTGCG GATCATCCTC 960 CTGAGCTATG GAAAGTCCAT GAGCCTCATC GAGATCGGGA ACCCCTCTCA GAGCCTGGAG 1020 AATGTCTGCC GCTGGGCCTA CCTCCAGCAG AAGCCAGACA CGGGCCACGA TGAATACCAC 1080 GATCACGCCA TCTTCCTCAC ACGGCAGGAC TTTGGGCCTT CCGGCATGCA AGGCTATGCT 1140 CCTGTCACCG GCATGTGCCA TCCGGTCCGC AGCTGCACCC TGAACCATGA GGACGGCTTC 1200 TCCTCAGCGT TTGTGGTGGC CCATGAGACT GGCCACGTGC TGGGCATGGA GCACGACGGG 1260 CAGGGCAACC GCTGTGGCGA CGAGGTGCGG CTGGGCAGCA TCATGGCGCC CCTGGTGCAG 1320 GCCGCCTTCC ACCGCTTCCA CTGGTCCCGC TGCAGCCAGC AGGAGCTGAG CCGCTACCTG 1380 CACTCCTATG ACTGCCTGCT GGATGACCCC TTCGCCCACG ACTGGCCGGC GCTGCCCCAG 1440 CTCCCGGGAC TGCACTACTC CATGAACGAG CAATGCCGCT TTGACTTCGG CCTGGGCTAC 1500 ATGATGTGCA CGGCGTTCCG GACCTTTGAC CCCTGCAAGC AGCTGTGGTG CAGCCATCCT 1560 GACAACCCCT ACTTTTGCAA GACCAAGAAG GGGCCCCCCT TGGACGGGAC TATGTGTGCA 1620 CCTGGCAAGC ATTGTTTTAA AGGACACTGC ATCTGGCTGA CACCTGACAT CCTCAAACGG 1680 GACGGCAGCT GGGGCGCTTG GAGTCCGTTT GGCTCCTGCT CACGTACCTG TGGCACGGGC 1740 GTGAAGTTCA GGACCCGCCA GTGTGACAAC CCACACCCGG CCAACGGGGG CCGCACCTGC 1800 TCGGGCCTTG CCTACGACTT CCAGCTCTGC AGCCGCCAGG ACTGCCCCGA CTCCCTGGCT 1860 GACTTCCGCG AGGAGCAGTG CCGCCAGTGG GACCTGTACT TCGAGCACGG CGACGCCCAG 1920 CACCACTGGC TGCCCCACGA GCACCGGGAT GCCAAGGAGA GATGCCACCT GTACTGCGAG 1980 TCCAGGGAGA CCGGGGAGGT GGTGTCCATG AAGCGCATGG TGCATGATGG GACGCGCTGC 2040 TCCTACAAGG ACGCCTTCAG CCTCTGTGTG CGCGGGGACT GCAGGAAGGT GGGCTGTGAC 2100 GGTGTGATCG GCTCCAGCAA GCAGGAAGAC AAGTGTGGCG TGTGCGGAGG GGACAACAGC 2160 CACTGCAAAG TGGTCAAGGG CACGTTCACA CGGTCACCCA AGAAGCATGG TTACATCAAG 2220 ATGTTTGAGA TCCCTGCAGG AGCCAGACAC CTGCTCATTC AGGAGGTAGA CGCCACCAGC 2280 CACCATCTGG CCGTCAAGAA CCTGGAGACA GGCAAGTTCA TCTTAAATGA AGAGAATGAC 2340 GTGGATGCCA GTTCCAAAAC CTTCATTGCC ATGGGCGTGG AGTGGGAGTA CAGAGACGAG 2400 GACGGCCGGG AGACGCTGCA GACCATGGGC CCCCTCCACG GCACCATCAC CGTTCTGGTC 2460 ATCCCGGTGG GAGACACCCG GGTCTCACTG ACGTACAAAT ACATGATCCA TGAGGACTCA 2520 CTGAATGTCG ATGACAACAA CGTCCTGGAA GAGGACTCTG TGGTCTACGA GTGGGCCCTG 2580 AAGAAGTGGT CTCCGTGCTC CAAGCCCTGT GGCGGAGGGT CCCAGTTCAC CAAGTATGGC 2640 TGCCGCCGGA GGCTGGACCA CAAGATGGTA CACCGTGGCT TCTGTGCCGC CCTCTCGAAG 2700 CCCAAAGCCA TCCGCAGAGC GTGCAACCCA CAGGAATGCT CCCAGCCAGT GTGGGTCACA 2760 GGCGAATGGG AGCCATGTAG CCAGACCTGT GGGCGGACAG GCATGCAGGT GCGCTCCGTG 2820 CGCTGCATTC AGCCGCTACA CGACAACACC ACCCGCTCCG TGCACGCCAA GCACTGCAAT 2880 GACGCCCGGC CCGAGAGCCG CCGGGCCTGC AGCCGCGAGC TCTGCCCTGG TCGTTGGCGA 2940 GCCGGGCCCT GGTCCCAGTG CTCAGTAACC TGTGGCAACG GCACCCAGGA GCGGCCAGTG 3000 CCCTGCCGCA CCGCGGACGA CAGCTTCGGC ATCTGCCAGG AGGAGCGTCC TGAGACAGCG 3060 AGGACCTGCA GGCTTGGCCC CTGTCCCCGA AACATCTCAG ATCCCTCCAA GAAGAGCTAC 3120 GTAGTTCAGT GGCTGTCCCG CCCGGACCCC GACTCGCCCA TCCGGAAGAT CTCGTCAAAG 3180 GGCCACTGCC AAGGCGACAA GTCAATATTC TGTAGGATGG AAGTCTTGTC CCGCTATTGC 3240 TCCATCCCAG GCTACAACAA GCTGTCCTGC AAGTCCTGTA ACCTGTACAA CAACCTCACC 3300 AACGTGGAGG GCAGGATAGA GCCACCGCCT GGGAAGCACA ACGACATTGA CGTGTTCATG 3360 CCTACCCTCC CAGTGCCCAC TGTAGCCATG GAGGTGCGGC CATCACCAAG CACCCCCCTG 3420 GAGGTCCCTC TCAATGCCTC CAGCACCAAT GCCACAGAGG ATCACCCAGA AACCAATGCC 3480 GTAGATGAAC CCTACAAAAT CCATGGCCTG GAAGATGAAG TCCAGCCACC CAACCTAATC 3540 CCTCGACGAC CGAGCCCCTA TGAAAAGACC AGAAACCAAA GAATCCAAGA GCTCATTGAT 3600 GAGATGCGGA AGAAAGAGAT GCTCGGAAAG TTCTAA 3636 Seq ID NO : 9 DNA sequence Nucleic Acid Accession # : NM 024022 Coding sequence : 202.. 1563 1 11 21 31 41 51 I ACCGGGCACC GGACGGCTCG GGTACTTTCG TTCTTAATTA GGTCATGCCC GTGTGAGCCA 60 GGAAAGGGCT GTGTTTATGG GAAGCCAGTA ACACTGTGGC CTACTATCTC TTCCGTGGTG 120 CCATCTACAT TTTTGGGACT CGGGAATTAT GAGGTAGAGG TGGAGGCGGA GCCGGATGTC 180 AGAGGTCCTG AAATAGTCAC CATGGGGGAA AATGATCCGC CTGCTGTTGA AGCCCCCTTC 240 TCATTCCGAT CGCTTTTTGG CCTTGATGAT TTGAAAATAA GTCCTGTTGC ACCAGATGCA 300 GATGCTGTTG CTGCACAGAT CCTGTCACTG CTGCCATTGA AGTTTTTTCC AATCATCGTC 360 ATTGGGATCA TTGCATTGAT ATTAGCACTG GCCATTGGTC TGGGCATCCA CTTCGACTGC 420 TCAGGGAAGT ACAGATGTCG CTCATCCTTT AAGTGTATCG AGCTGATAGC TCGATGTGAC 480 GGAGTCTCGG ATTGCAAAGA CGGGGAGGAC GAGTACCGCT GTGTCCGGGT GGGTGGTCAG 540 AATGCCGTGC TCCAGGTGTT CACAGCTGCT TCGTGGAAGA CCATGTGCTC CGATGACTGG 600 AAGGGTCACT ACGCAAATGT TGCCTGTGCC CAACTGGGTT TCCCAAGCTA TGTGAGTTCA 660 GATAACCTCA GAGTGAGCTC GCTGGAGGGG CAGTTCCGGG AGGAGTTTGT GTCCATCGAT 720 CACCTCTTGC CAGATGACAA GGTGACTGCA TTACACCACT CAGTATATGT GAGGGAGGGA 780 TGTGCCTCTG GCCACGTGGT TACCTTGCAG TGCACAGCCT GTGGTCATAG AAGGGGCTAC 840 AGCTCACGCA TCGTGGGTGG AAACATGTCC TTGCTCTCGC AGTGGCCCTG GCAGGCCAGC 900 CTTCAGTTCC AGGGCTACCA CCTGTGCGGG GGCTCTGTCA TCACGCCCCT GTGGATCATC 960 ACTGCTGCAC ACTGTGTTTA TGACTTGTAC CTCCCCAAGT CATGGACCAT CCAGGTGGGT 1020 CTAGTTTCCC TGTTGGACAA TCCAGCCCCA TCCCACTTGG TGGAGAAGAT TGTCTACCAC 1080 AGCAAGTACA AGCCAAAGAG GCTGGGCAAT GACATCGCCC TTATGAAGCT GGCCGGGCCA 1140 CTCACGTTCA ATGAAATGAT CCAGCCTGTG TGCCTGCCCA ACTCTGAAGA GAACTTCCCC 1200 GATGGAAAAG TGTGCTGGAC GTCAGGATGG GGGGCCACAG AGGATGGAGG TGACGCCTCC 1260 CCTGTCCTGA ACCACGCGGC CGTCCCTTTG ATTTCCAACA AGATCTGCAA CCACAGGGAC 1320 GTGTACGGTG GCATCATCTC CCCCTCCATG CTCTGCGCGG GCTACCTGAC GGGTGGCGTG 1380 GACAGCTGCC AGGGGGACAG CGGGGGGCCC CTGGTGTGTC AAGAGAGGAG GCTGTGGAAG 1440 TTAGTGGGAG CGACCAGCTT TGGCATCGGC TGCGCAGAGG TGAACAAGCC TGGGGTGTAC 1500 ACCCGTGTCA CCTCCTTCCT GGACTGGATC CACGAGCAGA TGGAGAGAGA CCTAAAAACC 1560 TGAAGAGGAA GGGGACAAGT AGCCACCTGA GTTCCTGAGG TGATGAAGAC AGCCCGATCC 1620 TCCCCTGGAC TCCCGTGTAG GAACCTGCAC ACGAGCAGAC ACCCTTGGAG CTCTGAGTTC 1680 CGGCACCAGT AGCAGGCCCG AAAGAGGCAC CCTTCCATCT GATTCCAGCA CAACCTTCAA 1740 GCTGCTTTTT GTTTTTTGTT TTTTTGAGGT GGAGTCTCGC TCTGTTGCCC AGGCTGGAGT 1800 GCAGTGGCGA AATCCCTGCT CACTGCAGCC TCCGCTTCCC TGGTTCAAGC GATTCTCTTG 1860

CCTCAGCTTC CCCAGTAGCT GGGACCACAG GTGCCCGCCA CCACACCCAA CTAATTTTTG 1920 TATTTTTAGT AGAGACAGGG TTTCACCATG TTGGCCAGGC TGCTCTCAAA CCCCTGACCT 1980 CAAATGATGT GCCTGCTTCA GCCTCCCACA GTGCTGGGAT TACAGGCATG GGCCACCACG 2040 CCTAGCCTCA CGCTCCTTTC TGATCTTCAC TAAGAACAAA AGAAGCAGCA ACTTGCAAGG 2100 GCGGCCTTTC CCACTGGTCC ATCTGGTTTT CTCTCCAGGG GTCTTGCAAA ATTCCTGACG 2160 AGATAAGCAG TTATGTGACC TCACGTGCAA AGCCACCAAC AGCCACTCAG AAAAGACGCA 2220 CCAGCCCAGA AGTGCAGAAC TGCAGTCACT GCACGTTTTC ATCTCTAGGG ACCAGAACCA 2280 AACCCACCCT TTCTACTTCC AAGACTTATT TTCACATGTG GGGAGGTTAA TCTAGGAATG 2340 ACTCGTTTAA GGCCTATTTT CATGATTTCT TTGTAGCATT TGGTGCTTGA CGTATTATTG 2400 TCCTTTGATT CCAAATAATA TGTTTCCTTC CCTCAAAAAA AAAAAAAAAA AAAAAAAAAA 2460 AAAAA Seq ID NO : 10 DNA Sequence Nucleic Acid Accession # : AK092195 Coding sequence : 1.. 2034 1 11 21 31 41 51 ATGCTGTCAT CCACTGACTT TACATTTGCT TCCTGGGAGC TTGTGGTCCG CGTTGACCAT 60 CCCAATGAAG AGCAGCAGAA AGACGTCACA CTGAGAGTAT CTGGAGACCT TCATGTTGGA 120 GGAGTGATGC TCAAGTTAGT AGAACAGATC AATATATCCC AAGACTGGTC AGACTTTGCT 180 CTTTGGTGGG AACAGAAGCA TTGCTGGCTT CTGAAAACCC ACTGGACCCT GGACAAATAT 240 GGGGTCCAGG CAGATGCAAA GCTTCTCTTC ACCCCTCAGC ATAAAATGCT GCGCCTTCGT 300 CTGCCGAATT TGAAGATGGT GAGGTTGCGA GTCAGCTTCT CAGCTGTGGT TTTTAAAGCT 360 GTCAGTGATA TCTGCAAAAT CCTGAATATT AGAAGATCAG AAGAGCTTTC CTTGTTAAAG 420 CCGTCTGGTG ACTATTTTAA GAAGAAGAAG AAAAAAGACA AAAATAATAA GGAACCCATA 480 ATTGAAGATA TTCTAAACCT GGAGAGTTCT CCAACAGCTT CAGGTTCATC AGTAAGTCCT 540 GGTTTATACA GTAAAACCAT GACCCCTATA TATGACCCCA TCAATGGAAC ACCAGCATCA 600 TCCACCATGA CTTGGTTCAG TGACAGCCCT TTGACGGAAC AAAACTGCAG CATCCTCGCA 660 TTCAGCCAAC CCCCCCAGTC CCCAGAAGCA CTTGCGGATA TGTACCAGCC TCGGTCTCTG 720 GTTGATAAAG CCAAGCTCAA TGCAGGTTGG CTAGACTCCT CACGCTCCCT TATGGAACAA 780 GGCATCCAAG AGGATGAGCA GCTGCTCTTA CGATTTAAAT ATTATTCTTT CTTCGACTTG 840 AATCCTAAAT ATGATGCTGT CCGAATAAAC CAACTCTATG AGCAAGCCAG GTGGGCCATT 900 CTCTTAGAAG AAATTGATTG CACAGAGGAA GAAATGTTGA TCTTTGCAGC TCTACAGTAC 960 CACATTAGCA AACTGTCGTT GTCTGCTGAA ACACAGGATT TTGCAGGCGA GTCCGAGGTT 1020 GATGAAATAG AAGCGGCGCT TTCTAATTTG GAAGTAACCC TAGAAGGTGG AAAAGCGGAC 1080 AGCCTTTTGG AGGACATTAC TGATATCCCT AAACTTGCAG ATAATCTCAA ATTATTTAGG 1140 CCCAAGAAGT TACTACCAAA AGCTTTCAAA CAATATTGGT TTATCTTTAA AGACACATCC 1200 ATAGCATACT TTAAAAATAA GGAACTTGAA CAAGGAGAAC CACTAGAAAA ACTAAATCTT 1260 AGAGGCTGCG AAGTTGTGCC CGATGTAAAT GTAGCAGGAA GAAAATTTGG AATCAAGTTA 1320 CTAATCCCTG TTGCCGATGG TATGAATGAA ATGTATTTGA GATGTGACCA TGAGAATCAA 1380 TACGCCCAAT GGATGGCTGC CTGCATGTTG GCATCGAAGG GCAAAACCAT GGCAGACAGC 1440 TCCTACCAGC CAGAGGTCCT CAACATCCTT TCATTTCTGA GGATGAAAAA CAGGAACTCT 1500 GCATCTCAGG TGGCTTCCAG TCTCGAAAAC ATGGATATGA ACCCAGAATG TTTTGTGTCA 1560 CCACGGTGTG CAAAAAGACA CAAATCCAAA CAGCTGGCCG CCCGGATCCT GGAGGCGCAC 1620 CAGAACGTGG CCCAGATGCC CCTGGTCGAA GCCAAGCTGC GGTTCATCCA GGCGTGGCAG 1680 TCACTGCCTG AGTTTGGCCT CACCTACTAC CTTGTCAGAT TTAAAGGAAG CAAAAAAGAT 1740 GACATTCTGG GAGTTTCATA TAACAGGTTG ATTAAAATTG ATGCAGCCAC CGGGATTCCA 1800 GTGACAACAT GGAGATTCAC AAATATCAAA CAGTGGAATG TAAACTGGGA AACCCGGCAG 1860 GTGGTCATCG AGTTTGACCA AAACGTCTTT ACTGCTTTCA CCTGCCTGAG TGCAGATTGC 1920 AAGATTGTGC ACGAGTACAT TGGCGGCTAC ATTTTCTTGT CCACCCGCTC CAAGGACCAG 1980 AATGAAACAC TCGATGAGGA CTTGTTCCAC AAATTGACCG GCGGTCAGGA TTGA 2034 Seq ID NO : 11 DNA Sequence Nucleic Acid Accession # : Nom032044 Coding sequence : 182.. 658 1 11 21 31 41 51 AAGATATAAA AGCTCCAGAA ACGTTGACTG GGACCACTGG AGACACTGAA GAAGGCAGGG 60 GCCCTTAGAG TCTTGGTTGC CAAACAGATT TGCAGATCAA GGAGAACCCA GGAGTTTCAA 120 AGAAGCGCTA GTAAGGTCTC TGAGATCCTT GCACTAGCTA CATCCTCAGG GTAGGAGGAA 180 GATGGCTTCC AGAAGCATGC GGCTGCTCCT ATTGCTGAGC TGCCTGGCCA AAACAGGAGT 240 CCTGGGTGAT ATCATCATGA GACCCAGCTG TGCTCCTGGA TGGTTTTACC ACAAGTCCAA 300 TTGCTATGGT TACTTCAGGA AGCTGAGGAA CTGGTCTGAT GCCGAGCTCG AGTGTCAGTC 360 TTACGGAAAC GGAGCCCACC TGGCATCTAT CCTGAGTTTA AAGGAAGCCA GCACCATAGC 420 AGAGTACATA AGTGGCTATC AGAGAAGCCA GCCGATATGG ATTGGCCTGC ACGACCCACA 480 GAAGAGGCAG CAGTGGCAGT GGATTGATGG GGCCATGTAT CTGTACAGAT CCTGGTCTGG 540 CAAGTCCATG GGTGGGAACA AGCACTGTGC TGAGATGAGC TCCAATAACA ACTTTTTAAC 600 TTGGAGCAGC AACGAATGCA ACAAGCGCCA ACACTTCCTG TGCAAGTACC GACCATAGAG 660 CAAGAATCAA GATTCTGCTA ACTCCTGCAC AGCCCCGTCC TCTTCCTTTC TGCTAGCCTG 720 GCTAAATCTG CTCATTATTT CAGAGGGGAA ACCTAGCAAA CTAAGAGTGA TAAGGGCCCT 780 ACTACACTGG CTTTTTTAGG CTTAGAGACA GAAACTTTAG CATTGGCCCA GTAGTGGCTT 840 CTAGCTCTAA ATGTTTGCCC CGCCATCCCT TTCCACAGTA TCCTTCTTCC CTCCTCCCCT 900 GTCTCTGGCT GTCTCGAGCA GTCTAGAAGA GTGCATCTCC AGCCTATGAA ACAGCTGGGT 960 CTTTGGCCAT AAGAAGTAAA GATTTGAAGA CAGAAGGAAG AAACTCAGGA GTAAGCTTCT 1020 AGACCCCTTC AGCTTCTACA CCCTTCTGCC CTCTCTCCAT TGCCTGCACC CCACCCCAGC 1080 CACTCAACTC CTGCTTGTTT TTCCTTTGGC CATAGGAAGG TTTACCAGTA GAATCCTTGC 1140 TAGGTTGATG TGGGCCATAC ATTCCTTTAA TAAACCATTG TGTACATAAG AAAAAAAAAA 1200 Seq ID NO : 12 DNA Sequence Nucleic Acid Accession # : XM 051860. 2 Coding sequence : 261.. 4346 1 11 21 31 41 51 ( GAGCTAGCGC TCAAGCAGAG CCCAGCGCGG TGCTATCGGA CAGAGCCTGG CGAGCGCAAG 60

CGGCGCGGGG AGCCAGCGGG GCTGAGCGCG GCCAGGGTCT GAACCCAGAT TTCCCAGACT 120 AGCTACCACT CCGCTTGCCC ACGCCCCGGG AGCTCGCGGC GCCTGGCGGT CAGCGACCAG 180 ACGTCCGGGG CCGCTGCGCT CCTGGCCCGC GAGGCGTGAC ACTGTCTCGG CTACAGACCC 240 AGAGGGAGCA CACTGCCAGG ATGGGAGCTG CTGGGAGGCA GGACTTCCTC TTCAAGGCCA 300 TGCTGACCAT CAGCTGGCTC ACTCTGACCT GCTTCCCTGG GGCCACATCC ACAGTGGCTG 360 CTGGGTGCCC TGACCAGAGC CCTGAGTTGC AACCCTGGAA CCCTGGCCAT GACCAAGACC 420 ACCATGTGCA TATCGGCCAG GGCAAGACAC TGCTGCTCAC CTCTTCTGCC ACGGTCTATT 480 CCATCCACAT CTCAGAGGGA GGCAAGCTGG TCATTAAAGA CCACGACGAG CCGATTGTTT 540 TGCGAACCCG GCACATCCTG ATTGACAACG GAGGAGAGCT GCATGCTGGG AGTGCCCTCT 600 GCCCTTTCCA GGGCAATTTC ACCATCATTT TGTATGGAAG GGCTGATGAA GGTATTCAGC 660 CGGATCCTTA CTATGGTCTG AAGTACATTG GGGTTGGTAA AGGAGGCGCT CTTGAGTTGC 720 ATGGACAGAA AAAGCTCTCC TGGACATTTC TGAACAAGAC CCTTCACCCA GGTGGCATGG 780 CAGAAGGAGG CTATTTTTTT GAAAGGAGCT GGGGCCACCG TGGAGTTATT GTTCATGTCA 840 TCGACCCCAA ATCAGGCACA GTCATCCATT CTGACCGGTT TGACACCTAT AGATCCAAGA 900 AAGAGAGTGA ACGTCTGGTC CAGTATTTGA ACGCGGTGCC CGATGGCAGG ATCCTTTCTG 960 TTGCAGTGAA TGATGAAGGT TCTCGAAATC TGGATGACAT GGCCAGGAAG GCGATGACCA 1020 AATTGGGAAG CAAACACTTC CTGCACCTTG GATTTAGACA CCCTTGGAGT TTTCTAACTG 1080 TGAAAGGAAA TCCATCATCT TCAGTGGAAG ACCATATTGA ATATCATGGA CATCGAGGCT 1140 CTGCTGCTGC CCGGGTATTC AAATTGTTCC AGACAGAGCA TGGCGAATAT TTCAATGTTT 1200 CTTTGTCCAG TGAGTGGGTT CAAGACGTGG AGTGGACGGA GTGGTTCGAT CATGATAAAG 1260 TATCTCAGAC TAAAGGTGGG GAGAAAATTT CAGACCTCTG GAAAGCTCAC CCAGGAAAAA 1320 TATGCAATCG TCCCATTGAT ATACAGGCCA CTACAATGGA TGGAGTTAAC CTCAGCACCG 1380 AGGTTGTCTA CAAAAAAGGC CAGGATTATA GGTTTGCTTG CTACGACCGG GGCAGAGCCT 1440 GCCGGAGCTA CCGTGTACGG TTCCTCTGTG GGAAGCCTGT GAGGCCCAAA CTCACAGTCA 1500 CCATTGACAC CAATGTGAAC AGCACCATTC TGAACTTGGA GGATAATGTA CAGTCATGGA 1560 AACCTGGAGA TACCCTGGTC ATTGCCAGTA CTGATTACTC CATGTACCAG GCAGAAGAGT 1620 TCCAGGTGCT TCCCTGCAGA TCCTGCGCCC CCAACCAGGT CAAAGTGGCA GGGAAACCAA 1680 TGTACCTGCA CATCGGGGAG GAGATAGACG GCGTGGACAT GCGGGCGGAG GTTGGGCTTC 1740 TGAGCCGGAA CATCATAGTG ATGGGGGAGA TGGAGGACAA ATGCTACCCC TACAGAAACC 1800 ACATCTGCAA TTTCTTTGAC TTCGATACCT TTGGGGGCCA CATCAAGTTT GCTCTGGGAT 1860 TTAAGGCAGC ACACTTGGAG GGCACGGAGC TGAAGCATAT GGGACAGCAG CTGGTGGGTC 1920 AGTACCCGAT TCACTTCCAC CTGGCCGGTG ATGTAGACGA AAGGGGAGGT TATGACCCAC 1980 CCACATACAT CAGGGACCTC TCCATCCATC ATACATTCTC TCGCTGCGTC ACAGTCCATG 2040 GCTCCAATGG CTTGTTGATC AAGGACGTTG TGGGCTATAA CTCTTTGGGC CACTGCTTCT 2100 TCACGGAAGA TGGGCCGGAG GAACGCAACA CTTTTGACCA CTGTCTTGGC CTCCTTGTCA 2160 AGTCTGGAAC CCTCCTCCCC TCGGACCGTG ACAGCAAGAT GTGCAAGATG ATCACAGAGG 2220 ACTCCTACCC GGGGTACATC CCCAAGCCCA GGCAAGACTG CAATGCTGTG TCCACCTTCT 2280 GGATGGCCAA TCCCAACAAC AACCTCATCA ACTGTGCCGC TGCAGGATCT GAGGAAACTG 2340 GATTTTGGTT TATTTTTCAC CACGTACCAA CGGGCCCCTC CGTGGGAATG TACTCCCCAG 2400 GTTATTCAGA GCACATTCCA CTGGGAAAAT TCTATAACAA CCGAGCACAT TCCAACTACC 2460 GGGCTGGCAT GATCATAGAC AACGGAGTCA AAACCACCGA GGCCTCTGCC AAGGACAAGC 2520 GGCCGTTCCT CTCAATCATC TCTGCCAGAT ACAGCCCTCA CCAGGACGCC GACCCGCTGA 2580 AGCCCCGGGA GCCGGCCATC ATCAGACACT TCATTGCCTA CAAGAACCAG GACCACGGGG 2640 CCTGGCTGCG CGGCGGGGAT GTGTGGCTGG ACAGCTGCCG GTTTGCTGAC AATGGCATTG 2700 GCCTGACCCT GGCCAGTGGT GGAACCTTCC CGTATGACGA CGGCTCCAAG CAAGAGATAA 2760 AGAACAGCTT GTTTGTTGGC GAGAGTGGCA ACGTGGGGAC GGAAATGATG GACAATAGGA 2820 TCTGGGGCCC TGGCGGCTTG GACCATAGCG GAAGGACCCT CCCTATAGGC CAGAATTTTC 2880 CAATTAGAGG AATTCAGTTA TATGATGGCC CCATCAACAT CCAAAACTGC ACTTTCCGAA 2940 AGTTTGTGGC CCTGGAGGGC CGGCACACCA GCGCCCTGGC CTTCCGCCTG AATAATGCCT 3000 GGCAGAGCTG CCCCCATAAC AACGTGACCG GCATTGCCTT TGAGGACGTT CCGATTACTT 3060 CCAGAGTGTT CTTCGGAGAG CCTGGGCCCT GGTTCAACCA GCTGGACATG GATGGGGATA 3120 AGACATCTGT GTTCCATGAC GTCGACGGCT CCGTGTCCGA GTACCCTGGC TCCTACCTCA 3180 CGAAGAATGA CAACTGGCTG GTCCGGCACC CAGACTGCAT CAATGTTCCC GACTGGAGAG 3240 GGGCCATTTG CAGTGGGTGC TATGCACAGA TGTACATTCA AGCCTACAAG ACCAGTAACC 3300 TGCGAATGAA GATCATCAAG AATGACTTCC CCAGCCACCC TCTTTACCTG GAGGGGGCGC 3360 TCACCAGGAG CACCCATTAC CAGCAATACC AACCGGTTGT CACCCTGCAG AAGGGCTACA 3420 CCATCCACTG GGACCAGACG GCCCCCGCCG AACTCGCCAT CTGGCTCATC AACTTCAACA 3480 AGGGCGACTG GATCCGAGTG GGGCTCTGCT ACCCGCGAGG CACCACATTC TCCATCCTCT 3540 CGGATGTTCA CAATCGCCTG CTGAAGCAAA CGTCCAAGAC GGGCGTCTTC GTGAGGACCT 3600 TGCAGATGGA CAAAGTGGAG CAGAGCTACC CTGGCAGGAG CCACTACTAC TGGGACGAGG 3660 ACTCAGGGCT GTTGTTCCTG AAGCTGAAAG CTCAGAACGA GAGAGAGAAG TTTGCTTTCT 3720 GCTCCATGAA AGGCTGTGAG AGGATAAAGA TTAAAGCTCT GATTCCAAAG AACGCAGGCG 3780 TCAGTGACTG CACAGCCACA GCTTACCCCA AGTTCACCGA GAGGGCTGTC GTAGACGTGC 3840 CGATGCCCAA GAAGCTCTTT GGTTCTCAGC TGAAAACAAA GGACCATTTC TTGGAGGTGA 3900 AGATGGAGAG TTCCAAGCAG CACTTCTTCC ACCTCTGGAA CGACTTCGCT TACATTGAAG 3960 TGGATGGGAA GAAGTACCCC AGTTCGGAGG ATGGCATCCA GGTGGTGGTG ATTGACGGGA 4020 ACCAAGGGCG CGTGGTGAGC CACACGAGCT TCAGGAACTC CATTCTGCAA GGCATACCAT 4080 GGCAGCTTTT CAACTATGTG GCGACCATCC CTGACAATTC CATAGTGCTT ATGGCATCAA 4140 AGGGAAGATA CGTCTCCAGA GGCCCATGGA CCAGAGTGCT GGAAAAGCTT GGGGCAGACA 4200 GGGGTCTCAA GTTGAAAGAG CAAATGGCAT TCGTTGGCTT CAAAGGCAGC TTCCGGCCCA 4260 TCTGGGTGAC ACTGGACACT GAGGATCACA AAGCCAAAAT CTTCCAAGTT GTGCCCATCC 4320 CTGTGGTGAA GAAGAAGAAG TTGTGAGGAC AGCTGCCGCC CGGTGCCACC TCGTGGTAGA 4380 CTATGACGGT GACTCTTGGC AGCAGACCAG TGGGGGATGG CTGGGTCCCC CAGCCCCTGC 4440 CAGCAGCTGC CTGGGAAGGC CGTGTTTCAG CCCTGATGGG CCAAGGGAAG GCTATCAGAG 4500 ACCCTGGTGC TGCCACCTGC CCCTACTCAA GTGTCTACCT GGAGCCCCTG GGGCGGTGCT 4560 GGCCAATGCT GGAAACATTC ACTTTCCTGC AGCCTCTTGG GTGCTTCTCT CCTATCTGTG 4620 CCTCTTCAGT GGGGGTTTGG GGACCATATC AGGAGACCTG GGTTGTGCTG ACAGCAAAGA 4680 TCCACTTTGG CAGGAGCCCT GACCCAGCTA GGAGGTAGTC TGGAGGGCTG GTCATTCACA 4740 GATCCCCATG GTCTTCAGCA GACAAGTGAG GGTGGTAAAT GTAGGAGAAA GAGCCTTGGC 4800 CTTAAGGAAA TCTTTACTCC TGTAAGCAAG AGCCAACCTC ACAGGATTAG GAGCTGGGGT 4860 AGAACTGGCT ATCCTTGGGG AAGAGGCAAG CCCTGCCTCT GGCCGTGTCC ACCTTTCAGG 4920 AGACTTTGAG TGGCAGGTTT GGACTTGGAC TAGATGACTC TCAAAGGCCC TTTTAGTTCT 4980 GAGATTCCAG AAATCTGCTG CATTTCACAT GGTACCTGGA ACCCAACAGT TCATGGATAT 5040 CCACTGATAT CCATGATGCT GGGTGCCCCA GCGCACACGG GATGGAGAGG TGAGAACTAA 5100

TGCCTAGCTT GAGGGGTCTG CAGTCCAGTA GGGCAGGCAG TCAGGTCCAT GTGCACTGCA 5160 ATGCCAGGTG GAGAAATCAC AGAGAGGTAA AATGGAGGCC AGTGCCATTT CAGAGGGGAG 5220 GCTCAGGAAG GCTTCTTGCT TACAGGAATG AAGGCTGGGG GCATTTTGCT GGGGGGAGAT 5280 GAGGCAGCCT CTGGAATGGC TCAGGGATTC AGCCCTCCCT GCCGCTGCCT GCTGAAGCTG 5340 GTGACTACGG GGTCGCCCTT TGCTCACGTC TCTCTGGCCC ACTCATGATG GAGAAGTGTG 5400 GTCAGAGGGG AGCAATGGGC TTTGCTGCTT ATGAGCACAG AGGAATTCAG TCCCCAGGCA 5460 GCCCTGCCTC TGACTCCAAG AGGGTGAAGT CCACAGAAGT GAGCTCCTGC CTTAGGGCCT 5520 CATTTGCTCT TCATCCAGGG AACTGAGCAC AGGGGGCCTC CAGGAGACCC TAGATGTGCT 5580 CGTACTCCCT CGGCCTGGGA TTTCAGAGCT GGAAATATAG AAAATATCTA GCCCAAAGCC 5640 TTCATTTTAA CAGATGGGGA AAGTGAGCCC CCAAGATGGG AAAGAACCAC ACAGCTAAGG 5700 GAGGGCCTGG GGAGCCCCAC CCTAGCCCTT GCTGCCACAC CACATTGCCT CAACAACCGG 5760 CCCCAGAGTG CCCAGGCACT CCTGAGGTAG CTTCTGGAAA TGGGGACAAG TCCCCTCGAA 5820 GGAAAGGAAA TGACTAGAGT AGAATGACAG CTAGCAGATC TCTTCCCTCC TGCTCCCAGC 5880 GCACACAAAC CCGCCCTCCC CTTGGTGTTG GCGGTCCCTG TGGCCTTCAC TTTGTTCACT 5940 ACCTGTCAGC CCAGCCTGGG TGCACAGTAG CTGCAACTCC CCATTGGTGC TACCTGGCTC 6000 TCCTGTCTCT GCAGCTCTAC AGGTGAGGCC CAGCAGAGGG AGTAGGGCTC GCCATGTTTC 6060 TGGTGAGCCA ATTTGGCTGA TCTTGGGTGT CTGAACAGCT ATTGGGTCCA CCCCAGTCCC 6120 TTTCAGCTGC TGCTTAATGC CCTGCTCTCT CCCTGGCCCA CCTTATAGAG AGCCCAAAGA 6180 GCTCCTGTAA GAGGGAGAAC TCTATCTGTG GTTTATAATC TTGCACGAGG CACCAGAGTC 6240 TCCCTGGGTC TTGTGATGAA CTACATTTAT CCCCTTTCCT GCCCCAACCA CAAACTCTTT 6300 CCTTCAAAGA GGGCCTGCCT GGCTCCCTCC ACCCAACTGC ACCCATGAGA CTCGGTCCAA 6360 GAGTCCATTC CCCAGGTGGG AGCCAACTGT CAGGGAGGTC TTTCCCACCA AACATCTTTC 6420 AGCTGCTGGG AGGTGACCAT AGGGCTCTGC TTTTAAAGAT ATGGCTGCTT CAAAGGCCAG 6480 AGTCACAGGA AGGACTTCTT CCAGGGAGAT TAGTGGTGAT GGAGAGGAGA GTTAAAATGA 6540 CCTCATGTCC TTCTTGTCCA CGGTTTTGTT GAGTTTTCAC TCTTCTAATG CAAGGGTCTC 6600 ACACTGTGAA CCACTTAGGA TGTGATCACT TTCAGGTGGC CAGGAATGTT GAATGTCTTT 6660 GGCTCAGTTC ATTTAAAAAA GATATCTATT TGAAAGTTCT CAGAGTTGTA CATATGTTTC 6720 ACAGTACAGG ATCTGTACAT AAAAGTTTCT TTCCTAAACC ATTCACCAAG AGCCAATATC 6780 TAGGCATTTT CTTGGTAGCA CAAATTTTCT TATTGCTTAG AAAATTGTCC TCCTTGTTAT 6840 TTCTGTTTGT AAGACTTAAG TGAGTTAGGT CTTTAAGGAA AGCAACGCTC CTCTGAAATG 6900 CTTGTCTTTT TTCTGTTGCC GAAATAGCTG GTCCTTTTTC GGGAGTTAGA TGTATAGAGT 6960 GTTTGTATGT AAACATTTCT TGTAGGCATC ACCATGAACA AAGATATATT TTCTATTTAT 7020 TTATTATATG TGCACTTCAA GAAGTCACTG TCAGAGAAAT AAAGAATTGT CTTAAATGTC 7080 Seq ID NO : 13 DNA Sequence Nucleic Acid Accession # : NM012112 Coding sequence : 429.. 2672 1 11 21 31 41 51 TCAGACCTGT AGGCCTGATA GACTGATTAA ACCACAGAAG GTGACCTGCT GAGAAAAGTG 60 GTACAAATAC TGGGAAAAAC CTGCTCTTCT GCGTTAAGTG GGAGACAATG TCACAAGTTA 120 AAAGCTCTTA TTCCTATGAT GCCCCCTCGG ATTTCATCAA TTTTTCATCC TTGGATGATG 180 AAGGAGATAC TCAAAACATA GATTCATGGT TTGAGGAGAA GGCCAATTTG GAGAATAAGT 240 TACTGGGGAA GAATGGAACT GGAGGGCTTT TTCAGGGCAA AACTCCTTTG AGAAAGGCTA 300 ATCTTCAGCA AGCTATTGTC ACACCTTTGA AACCAGTTGA CAACACTTAC TACAAAGAGG 360 CAGAAAAAGA AAATCTTGTG GAACAATCCA TTCCGTCAAA TGCTTGTTCT TCCCTGGAAG 420 TTGAGGCAGC CATATCAAGA AAAACTCCAG CCCAGCCTCA GAGAAGATCT CTTAGGCTTT 480 CTGCTCAGAA GGATTTGGAA CAGAAAGAAA AGCATCATGT AAAAATGAAA GCCAAGAGAT 540 GTGCCACTCC TGTAATCATC GATGAAATTC TACCCTCTAA GAAAATGAAA GTTTCTAACA 600 ACAAAAAGAA GCCAGAGGAA GAAGGCAGTG CTCATCAAGA TACTGCTGAA AAGAATGCAT 660 CTTCCCCAGA GAAAGCCAAG GGTAGACATA CTGTGCCTTG TATGCCACCT GCAAAGCAGA 720 AGTTTCTAAA AAGTACTGAG GAGCAAGAGC TGGAGAAGAG TATGAAAATG CAGCAAGAGG 780 TGGTGGAGAT GCGGAAAAAG AATGAAGAAT TCAAGAAACT TGCTCTGGCT GGAATAGGGC 840 AACCTGTGAA GAAATCAGTG AGCCAGGTCA CCAAATCAGT TGACTTCCAC TTCCGCACAG 900 ATGAGCGAAT CAAACAACAT CCTGAGAACC AGGAGGAATA TAAGGAAGTG AACTTTACAT 960 CTGAACTACG AAAGCATCCT TCATCTCCTG CCCGAGTGAC TAAGGGATGT ACCATTGTTA 1020 AGCCTTTCAA CCTGTCCCAA GGAAAGAAAA GAACATTTGA TGAAACAGTT TCTACATATG 1080 TGCCCCTTGC ACAGCAAGTT GAAGACTTCC ATAAACGAAC CCCTAACAGA TATCATTTGA 1140 GGAGCAAGAA GGATGATATT AACCTGTTAC CCTCCAAATC TTCTGTGACC AAGATTTGCA 1200 GAGACCCACA GACTCCTGTA CTGCAAACCA AACACCGTGC ACGGGCTGTG ACCTGCAAAA 1260 GTACAGCAGA GCTGGAGGCT GAGGAGCTCG AGAAATTGCA ACAATACAAA TTCAAAGCAC 1320 GTGAACTTGA TCCCAGAATA CTTGAAGGTG GGCCCATCTT GCCCAAGAAA CCACCTGTGA 1380 AACCACCCAC CGAGCCTATT GGCTTTGATT TGGAAATTGA GAAAAGAATC CAGGAGCGAG 1440 AATCAAAGAA GAAAACAGAG GATGAACACT TTGAATTTCA TTCCAGACCT TGCCCTACTA 1500 AGATTTTGGA AGATGTTGTG GGTGTTCCTG AAAAGAAGGT ACTTCCAATC ACCGTCCCCA 1560 AGTCACCAGC CTTTGCATTG AAGAACAGAA TTCGAATGCC CACCAAAGAA GATGAGGAAG 1620 AGGACGAACC GGTAGTGATA AAAGCTCAAC CTGTGCCACA TTATGGGGTG CCTTTTAAGC 1680 CCCAAATCCC AGAGGCAAGA ACTGTGGAAA TATGCCCTTT CTCCTTTGAT TCTCGAGACA 1740 AAGAACGTCA GTTACAGAAG GAGAAGAAAA TAAAAGAACT GCAGAAAGGG GAGGTGCCCA 1800 AGTTCAAGGC ACTTCCCTTG CCTCATTTTG ACACCATTAA CCTGCCAGAG AAGAAGGTAA 1860 AGAATGTGAC CCAGATTGAA CCTTTCTGCT TGGAGACTGA CAGAAGAGGT GCTCTGAAGG 1920 CACAGACTTG GAAGCACCAG CTGGAAGAAG AACTGAGACA GCAGAAAGAA GCAGCTTGTT 1980 TCAAGGCTCG TCCAAACACC GTCATCTCTC AGGAGCCCTT TGTTCCCAAG AAAGAGAAGA 2040 AATCAGTTGC TGAGGGCCTT TCTGGTTCTC TAGTTCAGGA ACCTTTTCAG CTGGCTACTG 2100 AGAAGAGAGC CAAAGAGCGG CAGGAGCTGG AGAAGAGAAT GGCTGAGGTA GAAGCCCAGA 2160 AAGCCCAGCA GTTGGAGGAG GCCAGACTAC AGGAGGAAGA GCAGAAAAAA GAGGAGCTGG 2220 CCAGGCTACG GAGAGAACTG GTGCATAAGG CAAATCCAAT ACGCAAGTAC CAGGGTCTGG 2280 AGATAAAGTC AAGTGACCAG CCTCTGACTG TGCCTGTATC TCCCAAATTC TCCACTCGAT 2340 TCCACTGCTA AACTCAGCTG TGAGCTGCGG ATACCGCCCG GCAATGGGAC CTGCTCTTAA 2400 CCTCAAACCT AGGACCGTCT TGCTTTGTCA TTGGGCATGG AGAGAACCCA TTTCTCCAGA 2460 CTTTTACCTA CCCGTGCCTG AGAAAGCATA CTTGACAACT GTGGACTCCA GTTTTGTTGA 2520 GAATTGTTTT CTTACATTAC TAAGGCTAAT AATGAGATGT AACTCATGAA TGTCTCGATT 2580 AGACTCCATG TAGTTACTTC CTTTAAACCA TCAGCCGGCC TTTTATATGG GTCTTCACTC 2640 TGACTAGAAT TTAGTCTCTG TGTCAGCACA GTGTAATCTC TATTGCTATT GCCCCTTACG 2700

ACTCTCACCC TCTCCCCAAC TTTTTTTAAA AATTTTAACC AGAAAATAAA GATAGTTAAA 2760 TCCTAAGATA GAGATTAAGT CATGGTTTAA ATGAGGAACA ATCAGTAAAT CAGATTCTGT 2820 CCTCTTCTCT GCATACCGTG AATTTATAGT TAAGGATCCC TTTGCTGTGA GGGTAGAAAA 2880 CCTCACCAAC TGCACCAGTG AGGAAGAAGA CTGCGTGGAT TCATGGGGAG CCTCACAGCA 2940 GCCACGCAGC AGGCTCTGGG TGGGGCTGCC GTTAAGGCAC GTTCTTTCCT TACTGGTGCT 3000 GATAACAACA GGGAACCGTG CAGTGTGCAT TTTAAGACCT GGCCTGGAAT AAATACGTTT 3060 TGTCTTTCCC TC 3072 Seq ID NO : 14 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 ATTTCTTGAG ATGGCTCCTC TTGGAACTAT GCATCTCTCC TGATACTTGG ATGCTTTTCC 60 TCTGACTGAT GAAGATCCTG AATACCAAAG. AGGGCCGCTG AAAGGGCTCT AGGAGTACAC 120 CTTCTAGGAA CCCTAAGCCA GAGAGAGGCT TCACTACATC ATGCTTCCTG ACATCTCTCC 180 CTTTGAAGAG CAGTCAGACT CCTGCTTTGC TCTTCAGACT TAATTTGGGG GTTTAACAGG 240 TGAGGTTGCT GGGGGAACTC TTTTACAACA TCTCTCTGAA AGAATCCGGG CTGCCAGTTT 300 CATTTGGTTT GGGTGTCAGT AGCATGATGG AAAGACAAAA AAACACAACT TGACATCTGC 360 AGAAATGGGT TCAAATTTTA CCTGCAACTC ACCAATTCTG TGGCCTTGGT TCAGCAATTA 420 AACTCCCTAA AATTCAGTTT TTTCTTTGTA AAATGGGGTT ATGAACAGTA CCTACTTCAA 480 AATGTGTTTG TGAAGATTAA AAAAGTTAAC ATAAAGAGTT TAGAAGAGTG TCTGGCATAT 540 TGTGCTCAAT AAGTGTTTAT TTATTTATTG CTGAATAAAC CAGTAATTTA ATTAGTAT 598 Seq ID NO : 15 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 63.. 3224 1 11 21 31 41 51 ( CAGGAATTTG TGGCGGAGAG GGCAAATAAC TGCGGCTCTC CCGGCGCCCC GATGCTCGCA 60 CCATGTCGAG GCGCAAGCAG GCGAAACCCC AGCACATCAA CTCGGAGGAG GACCAGGGCG 120 AGCAGCAGCC GCAGCAGCAG ACCCCGGAGT TTGCAGATGC GGCCCCAGCG GCGCCCGCGG 180 CGGGGGAGCT GGGTGCTCCA GTGAACCACC CAGGGAATGA CGAGGTGGCG AGTGAGGATG 240 AAGCCACAGT AAAGCGGCTT CGTCGGGAGG AGACGCACGT CTGTGAGAAA TGCTGTGCGG 300 AGTTCTTCAG CATCTCTGAG TTCCTGGAAC ATAAGAAAAA TTGCACTAAA AATCCACCTG 360 TCCTCATCAT GAATGACAGC GAGGGGCCTG TGCCTTCAGA AGACTTCTCC GGAGCTGTAC 420 TGAGCCACCA GCCCACCAGT CCCGGCAGTA AGGACTGTCA CAGGGAGAAT GGCGGCAGCT 480 CAGAGGACAT GAAGGAGAAG CCGGATGCGG AGTCTGTGGT GTACCTAAAG ACAGAGACAG 540 CCCTGCCACC CACCCCCCAG GACATAAGCT ATTTAGCCAA AGGCAAAGTG GCCAACACTA 600 ATGTGACCTT GCAGGCACTA CGGGGCACCA AGGTGGCGGT GAATCAGCGG AGCGCGGATG 660 CACTCCCTGC CCCCGTGCCT GGTGCCAACA GCATCCCGTG GGTCCTCGAG CAGATCTTGT 720 GTCTGCAGCA GCAGCAGCTA CAGCAGATCC AGCTCACCGA GCAGATCCGC ATCCAGGTGA 780 ACATGTGGGC CTCCCACGCC CTCCACTCAA GCGGGGCAGG GGCCGACACT CTGAAGACCT 840 TGGGCAGCCA CATGTCTCAG CAGGTTTCTG CAGCTGTGGC TTTGCTCAGC CAGAAAGCTG 900 GAAGCCAAGG TCTGTCTCTG GATGCCTTGA AACAAGCCAA GCTACCTCAC GCCAACATCC 960 CTTCTGCCAC CAGCTCCCTG TCCCCAGGGC TGGCACCCTT CACTCTGAAG CCGGATGGGA 1020 CCCGGGTGCT CCCGAACGTC ATGTCCCGCC TCCCGAGCGC TTTGCTTCCT CAGGCCCCGG 1080 GCTCGGTGCT CTTCCAGAGC CCTTTCTCCA CTGTGGCGCT AGACACATCC AAGAAAGGGA 1140 AGGGGAAGCC ACCGAACATC TCCGCGGTGG ATGTCAAACC CAAAGACGAG GCGGCCCTCT 1200 ACAAGCACAA GTGTAAGTAC TGTAGCAAGG TTTTTGGGAC TGATAGCTCC TTGCAGATCC 1260 ACCTCCGCTC CCACACTGGA GAGAGACCCT TCGTGTGCTC TGTCTGTGGT CATCGCTTCA 1320 CCACCAAGGG CAACCTCAAG GTGCACTTTC ACCGACATCC CCAGGTGAAG GCAAACCCCC 1380 AGCTGTTTGC CGAGTTCCAG GACAAAGTGG CGGCCGGCAA TGGCATCCCC TATGCACTCT 1440 CTGTACCTGA CCCCATAGAT GAACCGAGTC TTTCTTTAGA CAGCAAACCT GTCCTTGTAA 1500 CCACCTCTGT AGGGCTACCT CAGAATCTTT CTTCGGGGAC TAATCCCAAG GACCTCACGG 1560 GTGGCTCCTT GCCCGGTGAC CTGCAGCCTG GGCCTTCTCC AGAAAGTGAG GGTGGACCCA 1620 CACTCCCTGG GGTGGGACCA AACTATAATT CCCCAAGGGC TGGTGGCTTC CAAGGGAGTG 1680 GGACCCCTGA GCCAGGGTCA GAGACCCTGA AATTGCAGCA GTTGGTGGAG AACATTGACA 1740 AGGCCACCAC TGATCCCAAC GAATGTCTCA TTTGCCACCG AGTCTTAAGC TGTCAGAGCT 1800 CCCTCAAGAT GCATTATCGC ACCCACACCG GGGAGAGACC GTTCCAGTGT AAGATCTGTG 1860 GCCGAGCCTT TTCTACCAAA GGTAACCTGA AGACACACCT TGGGGTTCAC CGAACCAACA 1920 CATCCATTAA GACGCAGCAT TCGTGCCCCA TCTGCCAGAA GAAGTTCACT AATGCCGTGA 1980 TGCTGCAGCA ACATATTCGG ATGCACATGG GCGGTCAGAT TCCCAACACG CCCCTGCCAG 2040 AGAATCCCTG TGACTTTACG GGTTCTGAGC CAATGACCGT GGGTGAGAAC GGCAGCACCG 2100 GCGCTATCTG CCATGATGAT GTCATCGAAA GCATCGATGT AGAGGAAGTC AGCTCCCAGG 2160 AGGCTCCCAG CAGCTCCTCC AAGGTCCCCA CGCCTCTTCC CAGCATCCAC TCGGCATCAC 2220 CCACGCTAGG GTTTGCCATG ATGGCTTCCT TAGATGCCCC AGGGAAAGTG GGTCCTGCCC 2280 CTTTTAACCT GCAGCGCCAG GGCAGCAGAG AAAACGGTTC CGTGGAGAGC GATGGCTTGA 2340 CCAACGACTC ATCCTCGCTG ATGGGAGACC AGGAGTATCA GAGCCGAAGC CCAGATATCC 2400 TGGAAACCAC ATCCTTCCAG GCACTCTCCC CGGCCAATAG TCAAGCCGAA AGCATCAAGT 2460 CAAAGTCTCC CGATGCTGGG AGCAAAGCAG AGAGCTCCGA GAACAGCCGC ACTGAGATGG 2520 AAGGTCGGAG CAGTCTCCCT TCCACGTTTA TCCGAGCCCC GCCGACCTAT GTCAAGGTTG 2580 AAGTTCCTGG CACATTTGTG GGACCCTCGA CATTGTCCCC AGGGATGACC CCTTTGTTAG 2640 CAGCCCAGCC ACGCCGACAG GCCAAGCAAC ATGGCTGCAC ACGGTGTGGG AAGAACTTCT 2700 CGTCTGCTAG CGCTCTTCAG ATCCACGAGC GGACTCACAC TGGAGAGAAG CCTTTTGTGT 2760 GCAACATTTG TGGGCGAGCT TTTACCACCA AAGGCAACTT AAAGGTTCAC TACATGACAC 2820 ACGGGGCGAA CAATAACTCA GCCCGCCGTG GAAGGAAGTT GGCCATCGAG AACACCATGG 2880 CTCTGTTAGG TACGGACGGA AAAAGAGTCT CAGAAATCTT TCCCAAGGAA ATCCTGGCCC 2940 CTTCAGTGAA TGTGGACCCT GTTGTGTGGA ACCAGTACAC CAGCATGCTC AATGGCGGTC 3000 TGGCCGTGAA GACCAATGAG ATCTCTGTGA TCCAGAGTGG GGGGGTTCCT ACCCTCCCGG 3060 TTTCCTTGGG GGCCACCTCC GTTGTGAATA ACGCCACTGT CTCCAAGATG GATGGCTCCC 3120 AGTCGGGTAT CAGTGCAGAT GTGGAAAAAC CAAGTGCTAC TGACGGCGTT CCCAAACACC 3180 AGTTTCCTCA CTTCCTGGAA GAAAACAAGA TTGCGGTCAG CTAAGGGAGA ACTTGCGTGG 3240 AAGGAGCAAT GCAGACACAG TGAAATCTCT AGAATCTGCT TTGTTTTGTA AGAACTCATC 3300 TCCTCCTGTT TTCTTTTTCT TACTGATATG CAAATGATGT TTACTACGTT GGTTGTGACC 3360

ACAACCTCAG GCAAGTGCTA CAATCACGAT TGTTGCTATG CTGCTTTGCA AAAAGTTG 3418 Seq ID NO : 16 DNA Sequence Nucleic Acid Accession # : NM005101 Coding sequence : 76.. 573 1 11 21 31 41 51 CGGCTGAGAG GCAGCGAACT CATCTTTGCC AGTACAGGAG CTTGTGCCGT GGCCCACAGC 60 CCACAGCCCA CAGCCATGGG CTGGGACCTG ACGGTGAAGA TGCTGGCGGG CAACGAATTC 120 CAGGTGTCCC TGAGCAGCTC CATGTCGGTG TCAGAGCTGA AGGCGCAGAT CACCCAGAAG ISO ATTGGCGTGC ACGCCTTCCA GCAGCGTCTG GCTGTCCACC CGAGCGGTGT GGCGCTGCAG 240 GACAGGGTCC CCCTTGCCAG CCAGGGCCTG GGCCCTGGCA GCACGGTCCT GCTGGTGGTG 300 GACAAATGCG ACGAACCTCT GAGCATCCTG GTGAGGAATA ACAAGGGCCG CAGCAGCACC 360 TACGAGGTCC GGCTGACGCA GACCGTGGCC CACCTGAAGC AGCAAGTGAG CGGGCTGGAG 420 GGTGTGCAGG ACGACCTGTT CTGGCTGACC TTCGAGGGGA AGCCCCTGGA GGACCAGCTC 480 CCGCTGGGGG AGTACGGCCT CAAGCCCCTG AGCACCGTGT TCATGAATCT GCGCCTGCGG 540 GGAGGCGGCA CAGAGCCTGG CGGGCGGAGC TAAGGGCCTC CACCAGCATC CGAGCAGGAT 600 CAAGGGCCGG AAATAAAGGC TGTTGTAAGA GAAT 634 Seq ID NO : 17 DNA sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 62.. 895 1 11 21 31 41 51 CACTGCTCTG AGAATTTGTG AGCAGCCCCT AACAGGCTGT TACTTCACTA CAACTGACGA 60 TATGATCATC TTAATTTACT TATTTCTCTT GCTATGGGAA GACACTCAAG GATGGGGATT 120 CAAGGATGGA ATTTTTCATA ACTCCATATG GCTTGAACGA GCAGCCGGTG TGTACCACAG 180 AGAAGCACGG TCTGGCAAAT ACAAGCTCAC CTACGCAGAA GCTAAGGCGG TGTGTGAATT 240 TGAAGGCGGC CATCTCGCAA CTTACAAGCA GCTAGAGGCA GCCAGAAAAA TTGGATTTCA 300 TGTCTGTGCT GCTGGATGGA TGGCTAAGGG CAGAGTTGGA TACCCCATTG TGAAGCCAGG 360 GCCCAACTGT GGATTTGGAA AAACTGGCAT TATTGATTAT GGAATCCGTC TCAATAGGAG 420 TGAAAGATGG GATGCCTATT GCTACAACCC ACACGCAAAG GAGTGTGGTG GCGTCTTTAC 480 AGATCCAAAG CAAATTTTTA AATCTCCAGG CTTCCCAAAT GAGTACGAAG ATAACCAAAT 540 CTGCTACTGG CACATTAGAC TCAAGTATGG TCAGCGTATT CACCTGAGTT TTTTAGATTT 600 TGACCTTGAA GATGACCCAG GTTGCTTGGC TGATTATGTT GAAATATATG ACAGTTACGA 660 TGATGTCCAT GGCTTTGTGG GAAGATACTG TGGAGATGAG CTTCCAGATG ACATCATCAG 720 TACAGGAAAT GTCATGACCT TGAAGTTTCT AAGTGATGCT TCAGTGACAG CTGGAGGTTT 780 CCAAATCAAA TATGTTGCAA TGGATCCTGT ATCCAAATCC AGTCAAGGAA AAAATACAAG 840 TACTACTTCT ACTGGAAATA AAAACTTTTT AGCTGGAAGA TTTAGCCACT TATAAAAAAA 900 AAAAAAAGGA TGATCAAAAC ACACAGTGTT TATGTTGGAA TCTTTTGGAA CTCCTTTGAT 960 CTCACTGTTA TTATTAACAT TTATTTATTA TTTTTCTAAA TGTGAAAGCA ATACATAATT 1020 TAGGGAAAAT TGGAAAATAT AGGAAACTTT AAACGAGAAA ATGAAACCTC TCATAATCCC 1080 ACTGCATAGA AATAACAAGC GTTAACATTT TCATATTTTT TTCTTTCAGT CATTTTTCTA 1140 TTTGTGGTAT ATGTATATAT GTACCTATAT GTATTTGCAT TTGAAATTTT GGAATCCTGC 1200 TCTATGTACA GTTTTGTATT ATACTTTTTA AATCTTGAAC TTTATAAACA TTTTCTGAAA 1260 TCATTGATTA TTCTACAAAA ACATGATTTT AAACAGCTGT AAAATATTCT ATGATATGAA 1320 TGTTTTATGC ATTATTTAAG CCTGTCTCTA TTGTTGGAAT TTCAGGTCAT TTTCATAAAT 1380 ATTGTTGCAA TAAATATCCT TGAACACACA AAAAAAAAAA AA Seq ID NO : 18 DNA sequence Nucleic Acid Accession # : NM007115. 1 Coding sequence : 69.. 902 1 11 21 31 41 51 1 1 1 1 1 1 GAATTCGCAC TGCTCTGAGA ATTTGTGAGC AGCCCCTAAC AGGCTGTTAC TTCACTACAA 60 CTGACGATAT GATCATCTTA ATTTACTTAT TTCTCTTGCT ATGGGAAGAC ACTCAAGGAT 120 GGGGATTCAA GGATGGAATT TTTCATAACT CCATATGGCT TGAACGAGCA GCCGGTGTGT 180 ACCACAGAGA AGCACGGTCT GGCAAATACA AGCTCACCTA CGCAGAAGCT AAGGCGGTGT 240 GTGAATTTGA AGGCGGCCAT CTCGCAACTT ACAAGCAGCT AGAGGCAGCC AGAAAAATTG 300 GATTTCATGT CTGTGCTGCT GGATGGATGG CTAAGGGCAG AGTTGGATAC CCCATTGTGA 360 AGCCAGGGCC CAACTGATGA TTTGGAAAAA CTGGCATTAT TGATTATGGA ATCCGTCTCA 420 ATAGGAGTGA AAGATGGGAT GCCTATTGCT ACAACCCACA CGCAAAGGAG TGTGGTGGCG 480 TCTTTACAGA TCCAAAGCGA ATTTTTAAAT CTCCAGGCTT CCCAAATGAG TACGAAGATA 540 ACCAAATCTG CTACTGGCAC ATTAGACTCA AGTATGGTCA GCGTATTCAC CTGAGTTTTT 600 TAGATTTTGA CCTTGAAGAT GACCCAGGTT GCTTGGCTGA TTATGTTGAA ATATATGACA 660 GTTACGATGA TGTCCATGGC TTTGTGGGAA GATACTGTGG AGATGAGCTT CCAGATGACA 720 TCATCAGTAC AGGAAATGTC ATGACCTTGA AGTTTCTAAG TGATGCTTCA GTGACAGCTG 780 GAGGTTTCCA AATCAAATAT GTTGCAATGG ATCCTGTATC CAAATCCAGT CAAGGAAAAA 840 ATACAAGTAC TACTTCTACT GGAAATAAAA ACTTTTTAGC TGGAAGATTT AGCCACTTAT 900 AAAAAAAAAA AAGGATGATC AAAACACACA GTGTTTATGT TGGAATCTTT TGGAACTCCT 960 TTGATCTCAC TGTTATTATT AACATTTATT TATTATTTTT CTAAATGTGA AAGAAATACA 1020 TAATTTAGGG AAAATTGGAA AATATAGGAA ACTTTAAACG AGAAAATGAA ACCTCTCATA 1080 ATCCCACTGC ATAGAAATAA CAAGCGTTAA CATTTTCATA TTTTTTTCTT TCAGTCATTT 1140 TTGTATTTGT GGTATATGTA TATATGTACC TATATGTATT TGCATTTGAA ATTTTGGAAT 1200 CCTGCTCTAT GTACAGTTTT GTATTATACT TTTTAAATCT TGAACTTTAT GAACATTTTC 1260 TGAAATCATT GATTATTCTA CAAAAACATG ATTTTAAACA GCTGTAAAAT ATTCTATGAT 1320 ATGAATGTTT TATGCATTAT TTAAGCCTGT CTCTATTGTT GGAATTTCAG GTCATTTTCA 1380 TAAATATTGT TGCAATAAAT ATCCTTCGGA ATTC Seq ID NO : 19 DNA Sequence Nucleic Acid Accession # : UM-006398. 1 Coding sequence : 19.. 516 1 11 21 31 41 51 (

GGCCCCTTGT CTGCAGAGAT GGCTCCCAAT GCTTCCTGCC TCTGTGTGCA TGTCCGTTCC 60 GAGGAATGGG ATTTAATGAC CTTTGATGCC AACCCATATG ACAGCGTGAA AAAAATCAAA 120 GAACATGTCC GGTCTAAGAC CAAGGTTCCT GTGCAGGACC AGGTTCTTTT GCTGGGCTCC 180 AAGATCTTAA AGCCACGGAG AAGCCTCTCA TCTTATGGCA TTGACAAAGA GAAGACCATC 240 CACCTTACCC TGAAAGTGGT GAAGCCCAGT GATGAGGAGC TGCCCTTGTT TCTTGTGGAG 300 TCAGGTGATG AGGCAAAGAG GCACCTCCTC CAGGTGCGAA GGTCCAGCTC AGTGGCACAA 360 GTGAAAGCAA TGATCGAGAC TAAGACGGGT ATAATCCCTG AGACCCAGAT TGTGACTTGC 420 AATGGAAAGA GACTGGAAGA TGGGAAGATG ATGGCAGATT ACGGCATCAG AAAGGGCAAC 480 TTACTCTTCC TGGCATCTTA TTGTATTGGA GGGTGACCAC CCTGGGGATG GGGTGTTGGC 540 AGGGGTCAAA AAGCTTATTT CTTTTAATCT CTTACTCAAC GAACACATCT TCTGATGATT 600 TCCCAAAATT AATGAGAATG AGATGAGTAG AGTAAGATTT GGGTGGGATG GGTAGGATGA 660 AGTATATTGC CCAACTCTAT GTTTCTTTGA TTCTAACACA ATTAATTAAG TGACATGATT 720 TTTACTAATG TATTACTGAG ACTAGTAAAT AAATTTTTAA GGCAAAATAG AGCATTC 777 Seq ID NO : 20 DNA Sequence Nucleic Acid Accession # : Nom 002358. 2 Coding sequence : 75.. 692 1 11 21 31 41 51 1 1 1 1 1 1 GGGAAGTGCT GTTGGAGCCG CTGTGGTTGC TGTCCGCGGA GTGGAAGCGC GTGCTTTTGT 60 TTGTGTCCCT GGCCATGGCG CTGCAGCTCT CCCGGGAGCA GGGAATCACC CTGCGCGGGA 120 GCGCCGAAAT CGTGGCCGAG TTCTTCTCAT TCGGCATCAA CAGCATTTTA TATCAGCGTG 180 GCATATATCC ATCTGAAACC TTTACTCGAG TGCAGAAATA CGGACTCACC TTGCTTGTAA 240 CTACTGATCT TGAGCTCATA AAATACCTAA ATAATGTGGT GGAACAACTG AAAGATTGGT 300 TATACAAGTG TTCAGTTCAG AAACTGGTTG TAGTTATCTC AAATATTGAA AGTGGTGAGG 360 TCCTGGAAAG ATGGCAGTTT GATATTGAGT GTGACAAGAC TGCAAAAGAT GACAGTGCAC 420 CCAGAGAAAA GTCTCAGAAA GCTATCCAGG ATGAAATCCG TTCAGTGATC AGACAGATCA 480 CAGCTACGGT GACATTTCTG CCACTGTTGG AAGTTTCTTG TTCATTTGAT CTGCTGATTT 540 ATACAGACAA AGATTTGGTT GTACCTGAAA AATGGGAAGA GTCGGGACCA CAGTTTATTA 600 CCAATTCTGA GGAAGTCCGC CTTCGTTCAT TTACTACTAC AATCCACAAA GTAAATAGCA 660 TGGTGGCCTA CAAAATTCCT GTCAATGACT GAGGATGACA TGAGGAAAAT AATGTAATTG 720 TAATTTTGAA ATGTGGTTTT CCTGAAATCA GGTCATCTAT AGTTGATATG TTTTATTTCA 780 TTGGTTAATT TTTACATGGA GAAAACCAAA ATGATACTTA CTGAACTGTG TGTAATTGTT 840 CCTTTATTTT TTTGGTACCT ATTTGACTTA CCATGGAGTT AACATCATGA ATTTATTGCA 900 CATTGTTCAA AAGGAACCAG GAGGTTTTTT TGTCAACATT GTGATGTATA TTCCTTTGAA 960 GATAGTAACT GTAGATGGAA AAACTTGTGC TATAAAGCTA GATGCTTTCC TAAATCAGAT 1020 GTTTTGGTCA AGTAGTTTGA CTCAGTATAG GTAGGGAGAT ATTTAAGTAT AAAATACAAC 1080 AAAGGAAGTC TAAATATTCA GAATCTTTGT TAAGGTCCTG AAAGTAACTC ATAATCTATA 1140 AACAATGAAA TATTGCTGTA TAGCTCCTTT TGACCTTCAT TTCATGTATA GTTTTCCCTA 1200 TTGAATCAGT TTCCAATTAT TTGACTTTAA TTTATGTAAC TTGAACCTAT GAAGCAATGG 1260 ATATTTGTAC TGTTTAATGT TCTGTGATAC AGAACTCTTA AAAATGTTTT TTCATGTGTT 1320 TTATAAAATC AAGTTTTAAG TGAAAGTGAG GAAATAAAGT TAAGTTTGTT TTAAAAAAAA 1380 AAAAAAAAAA 1390 Seq ID NO : 21 DNA sequence Nucleic Acid Accession # : Nom 001898. 1 Coding sequence : 57.. 482 1 11 21 31 41 51 1 1 1 1 1 1 GGCTCTCACC CTCCTCTCCT GCAGCTCCAG CTTTGTGCTC TGCCTCTGAG GAGACCATGG 60 CCCAGTATCT GAGTACCCTG CTGCTCCTGC TGGCCACCCT AGCTGTGGCC CTGGCCTGGA 120 GCCCCAAGGA GGAGGATAGG ATAATCCCGG GTGGCATCTA TAACGCAGAC CTCAATGATG 180 AGTGGGTACA GCGTGCCCTT CACTTCGCCA TCAGCGAGTA TAACAAGGCC ACCAAAGATG 240 ACTACTACAG ACGTCCGCTG CGGGTACTAA GAGCCAGGCA ACAGACCGTT GGGGGGGTGA 300 ATTACTTCTT CGACGTAGAG GTGGGCCGCA CCATATGTAC CAAGTCCCAG CCCAACTTGG 360 ACACCTGTGC CTTCCATGAA CAGCCAGAAC TGCAGAAGAA ACAGTTGTGC TCTTTCGAGA 420 TCTACGAAGT TCCCTGGGAG AACAGAAGGT CCCTGGTGAA ATCCAGGTGT CAAGAATCCT 480 AGGGATCTGT GCCAGGCCAT TCGCACCAGC CACCACCCAC TCCCACCCCC TGTAGTGCTC 540 CCACCCCTGG ACTGGTGGCC CCCACCCTGC GGGAGGCCTC CCCATGTGCC TGCGCCAAGA 600 GACAGACAGA GAAGGCTGCA GGAGTCCTTT GTTGCTCAGC AGGGCGCTCT GCCCTCCCTC 660 CTTCCTTCTT GCTTCTAATA GCCCTGGTAC ATGGTACACA CCCCCCCACC TCCTGCAATT 720 AAACAGTAGC ATCGCC Seq ID NO : 22 DNA sequence Nucleic Acid Accession # : Nom 007231. 1 Coding sequence : 89.. 2017 1 11 21 31 41 51 TAGGAACAGG GGAGAGTGCA CCTGCTACCA GTCAAGCTCA GCCAGACTGC AAGAGGAGGC 60 GAGGCGGAGC CAGCCGAGGG AGTGAACCAT GGACAAGTTG AAATGCCCGA GTTTCTTCAA 120 GTGCAGGGAG AAGGAGAAAG TGTCGGCTTC ATCAGAGAAT TTCCATGTTG GTGAAAATGA 180 TGAGAATCAG GACCGTGGTA ACTGGTCCAA AAAATCGGAT TATCTTCTAT CTATGATTGG 240 ATACGCAGTG GGATTAGGAA ATGTGTGGAG ATTTCCATAT CTGACCTACA GCAATGGTGG 300 AGGCGCCTTC TTGATACCTT ATGCAATTAT GTTAGCATTG GCTGGTTTAC CTTTGTTCTT 360 TCTGGAGTGT TCACTGGGAC AATTTGCTAG CTTAGGTCCA GTTTCAGTTT GGAGGATTCT 420 TCCATTGTTT CAAGGTGTGG GAATTACAAT GGTCCTGATC TCCATTTTTG TGACAATCTA 480 TTACAATGTC ATAATTGCCT ATAGTCTTTA CTACATGTTT GCTTCTTTTC AAAGTGAACT 540 ACCATGGAAA AATTGTTCTT CGTGGTCAGA TAAAAACTGT AGCAGATCAC CAATAGTAAC 600 TCACTGTAAT GTGAGTACAG TGAATAAAGG AATACAAGAG ATCATCCAAA TGAATAAAAG 660 CTGGGTAGAC ATCAACAATT TTACCTGCAT CAACGGCAGT GAAATTTATC AGCCAGGGCA 720 GCTTCCCAGT GAACAATATT GGAATAAAGT GGCGCTCCAA CGGTCAAGTG GAATGAATGA 780 GACTGGAGTA ATTGTTTGGT ATTTAGCACT TTGTCTTCTT CTGGCTTGGC TCATAGTTGG 840 AGCAGCACTA TTTAAAGGAA TCAAATCGTC TGGCAAGGTG GTATATTTTA CAGCTCTTTT 900 CCCCTATGTG GTCCTACTCA TCCTGTTAGT ACGAGGTGCA ACTCTGGAGG GTGCTTCAAA 960

AGGCATTTCA TACTATATTG GAGCCCAGTC AAATTTTACA AAACTTAAGG AAGCTGAGGT 1020 ATGGAAAGAT GCTGCCACTC AGATATTTTA CTCCCTTTCA GTGGCTTGGG GTGGCTTAGT 1080 TGCTCTATCA TCTTACAATA AGTTCAAAAA CAACTGCTTC TCTGATGCCA TTGTGGTTTG 1140 TTTGACAAAC TGTCTCACTA GCGTGTTTGC TGGATTTGCT ATTTTTTCTA TATTGGGACA 1200 CATGGCCCAT ATATCTGGAA AGGAAGTTTC TCAAGTTGTA AAATCAGGTT TTGATTTGGC 1260 ATTCATTGCC TATCCAGAGG CTCTAGCCCA ACTCCCAGGT GGTCCATTTT GGTCCATATT 1320 ATTTTTTTTC ATGCTTTTAA CTTTGGGTCT CGATTCTCAG TTTGCTTCGA TTGAAACGAT 1380 CACAACAACA ATTCAAGATT TATTTCCCAA AGTGATGAAG AAAATGAGGG TTCCCATAAC 1440 TTTGGGCTGC TGCTTGGTTT TGTTTCTCCT TGGTCTCGTC TGTGTGACTC AGGCTGGAAT 1500 TTACTGGGTT CATCTGATTG ACCACTTCTG TGCTGGATGG GGCATTTTAA TTGCAGCTAT 1560 ACTGGAGCTA GTTGGAATCA TCTGGATTTA TGGAGGGAAC AGATTCATTG AGGATACAGA 1620 AATGATGATT GGAGCAAAGA GGTGGATATT CTGGCTATGG TGGAGAGCTT GCTGGTTTGT 1680 AATTACGCCT ATCCTTTTGA TTGCAATATT TATCTGGTCA TTGGTGCAAT TTCATAGACC 1740 TAATTATGGC GCAATTCCAT ACCCTGACTG GGGAGTTGCT TTAGGCTGGT GTATGATTGT 1800 TTTCTGCATT ATTTGGATAC CAATTATGGC TATCATAAAA ATAATTCAGG CTAAAGGAAA 1860 CATCTTTCAA CGCCTTATAA GTTGCTGCAG ACCAGCTTCT AACTGGGGTC CATACCTGGA 1920 ACAACATCGT GGGGAAAGAT ATAAAGACAT GGTAGATCCT AAAAAAGAGG CTGACCATGA 1980 AATACCTACT GTTAGTGGCA GCAGAAAACC GGAATGAGAT CTCATTGAAA AAAATATATG 2040 ATTGTATAAT GTGATTTTTT TTAGAATAGG GGGAACCTTA TTTATTTGTG TGTTAACTGA 2100 ATAGGAAAAT GTACATACTA TGTTCATGAT AGTGTGATTT TTTTCACATT TAAGCAGGAA 2160 TGCAATATAA AAATGTGAAT CTCTTAATTC TCAGCCATGT GCTTATTATA TTTCTTTTTA 2220 GATTGTCTAT CTGTATAACA CACACACACA CACCTAAGAG TCTCTATTTC ACAATTATAT 2280 TTTTGTAAAT AGTATATGCA TTTTTAATAC ATTGGAGGCT TTATTTTGAA CTAATTTCTT 2340 AGAGAATAGT TATATTTTCT ATTACACAAG TTTAAAAATA TTATTAACTT GTATTTTCTT 2400 AATATACAAT CTATCTTTTC CACAAATATG AGTGGGAAAT AAATCAGCAC ATTTGAAAGA 2460 AAGTGTTAAA ACTGAAGGCC TCACTTAATT AGAAACGTGA TAAATATATG GACAAATGGA 2520 CTATACATAC TATAAGAGGA CTGTAGTTTA ATACTTTTTA CCCAAATATG TTTAAAAACA 2580 TCGTGCATTT GTTACAGCTC ATGTTTTCTA TATGAACTTA GTCATTAATG TTCTTTATAA 2640 AAAGTGAAAT AAGATGGAAA AATTAGGATC CTACAGCCAG TACGTGATAA ATCTAGAAAA 2700 TTGAGTTTTG AGTACCTCTT TTCCCATATA CAATCTTCCT TCCTTAGGTA ATTTGGAAGA 2760 AAACTATGAC CCATTTAATT TCTATTGTGT TTCACCAAAT TCAGTGTTGT TCATTATACC 2820 TCTCTGAAAT ATAGGTTTAA TTTCAAATAG AATATGGACT TAAATGTTAA TGAGAAACTG 2880 GCTTTAATCA ATTCTAGCAT TTTATTACTG TAATACAGGG CTGATAGAGT GATTTTGTCT 2940 TATATGAGTC AGTTACTACT TACAGGTGAT AACTTGCATA CTATTGGAAG ATAAAGTTGT 3000 CAAACTTGTC AAGAATGAGA AAAGCCAAAT TAGAAAATCC TATGTCCTAG TTTCCTTACC 3060 AAGGATAATT AAATATATCA CTAAGAGCTT TATATATTGA TTATATATTG TTGACAACTG 3120 GTTTAAGCAT CATAGCCTAT GATGATAAAC ACTGCCTATA TATGTAAATA GCTTTTCATC 3180 AATTCTTAAA TTTCTTAACC TAGGCTTCAG GGAGCATATG AAACCAAAAT TATATGGAAC 3240 ATTTTCTGTG TGTACATGTA CATGCATTTT TCTAGGGAGA GAGTCCGTAG GTTTATCAGA 3300 ATATCAAGGA AAACTGTGAC CCAAAGAAGT TTAAGAATCA CATACAGTGC TGCTGGCTTT 3360 TTGTGCTTGG CAAATGAGTG ACAATAGAAG AAATAATTTT TCTTACACAT TTTAAAACGT 3420 TTTCTCTTCC TTGTGATTGA AGATGAAAGG AGTAAGAAAT TAAGGCATTT GTTTAATTTA 3480 TACTGGTAAC TTATTTAGGG GGGAGGGGAC ATGAAGGTAG GTAAATAGGT AGGCCTCTAA 3540 TTGAACCACC TCTCTAAGTT ATGTACGTAT ATATAAGCTG AAATTGTGTT TGACATTCTG 3600 AGGGTTTTCT TTTTCTTTTT CCTTTTTTTT TTTTTTTGGT GGGGGGCTGG GGGTCAGAGT 3660 CTTGTTCTGT TGCCTGGGCT GGAGTGCAGT GGCATGATCT CAGCTCACTG CAACCTCTGC 3720 CTTCTGGATT CAAGTGATTC TCCTGCCTCA GCCTCTTGAG TAGCTGGGAC TACAGGTGCC 3780 CGCCACCACA CCAGCTAATT TTTGTATTTT TAGTAGAGGC GAAGTTTCCC CATGTTGGCC 3840 AGGCTGGTCT TGAACTCCCG ACCTCAAGTG ATCTGTCTAC CTCGGCCTCC TAAAGTGCTG 3900 AGATTACAGG TGTGAGCCAC CGTGCCCGGC CCATTCTAAG GGTTTTCTTT GAAGACAGGT 3960 CAAATGCTGT TAGTAAGTTT CAGGAGATTG TTAATTCCTC AGTTATACCA GATTTTATAA 4020 AATATTTGAG AATAGATGGC TAACAAGAGG TTAGAAATAC TTTTCCTTAA TTTTAATCCA 4080 CAGTATGTTA CATGCATTCT ACCACTACAT TTTGGTGCTA TTTAAGGTGT GCAATTTTCT 4140 ATAGGTGACT TTTGCAATTC AGGGAAGATT TGGGCATATT AAATGAAAGA ATATCTAATT 4200 GGGGGAGGTG TGAAGGGAAA GAAATTCTTT TCAAAAGCTG ACCACAAAGA GTAGTTAAAA 4260 GTTTTTGTCA CTATCTTCAC AAGTGTGTAA AGCACAGATT TCAACAGAGT GCTTGGCATA 4320 TTGTAGGGTG CTCAATGGTG GTTTTTATTA TTATTACTCA GATTCCACAG TGGCAAGAAA 4380 CATCATTCTA CATAATGGAA AACATTTACA TCAAATCCCA CTTACTTTAA TGCGAACTTG 4440 GAGATAATTT ATGGTATTGT ATTGTAAACC ATTAATGAAA ACTTTTTCAC AGTTGAGTGA 4500 AATTAAAATC ACTATATCTC Seq ID NO : 23 DNA sequence Nucleic Acid Accession # : Nom 006398. 1 Coding sequence : 19.. 516 1 11 21 31 41 51 GGCCCCTTGT CTGCAGAGAT GGCTCCCAAT GCTTCCTGCC TCTGTGTGCA TGTCCGTTCC 60 GAGGAATGGG ATTTAATGAC CTTTGATGCC AACCCATATG ACAGCGTGAA AAAAATCAAA 120 GAACATGTCC GGTCTAAGAC CAAGGTTCCT GTGCAGGACC AGGTTCTTTT GCTGGGCTCC 180 AAGATCTTAA AGCCACGGAG AAGCCTCTCA TCTTATGGCA TTGACAAAGA GAAGACCATC 240 CACCTTACCC TGAAAGTGGT GAAGCCCAGT GATGAGGAGC TGCCCTTGTT TCTTGTGGAG 300 TCAGGTGATG AGGCAAAGAG GCACCTCCTC CAGGTGCGAA GGTCCAGCTC AGTGGCACAA 360 GTGAAAGCAA TGATCGAGAC TAAGACGGGT ATAATCCCTG AGACCCAGAT TGTGACTTGC 420 AATGGAAAGA GACTGGAAGA TGGGAAGATG ATGGCAGATT ACGGCATCAG AAAGGGCAAC 480 TTACTCTTCC TGGCATCTTA TTGTATTGGA GGGTGACCAC CCTGGGGATG GGGTGTTGGC 540 AGGGGTCAAA AAGCTTATTT CTTTTAATCT CTTACTCAAC GAACACATCT TCTGATGATT 600 TCCCAAAATT AATGAGAATG AGATGAGTAG AGTAAGATTT GGGTGGGATG GGTAGGATGA 660 AGTATATTGC CCAACTCTAT GTTTCTTTGA TTCTAACACA ATTAATTAAG TGACATGATT 720 TTTACTAATG TATTACTGAG ACTAGTAAAT AAATTTTTAA GGCAAAATAG AGCATTC Seq ID NO : 24 DNA sequence Nucleic Acid Accession # : XM_094741. 1 Coding sequence : 1.. 948 1 11 21 31 41 51

I I I I I I ATGAAGGCCA ACTACAGCGC AGAGGAGCGC TTTCTCCTGC TGGGTTTCTC CGACTGGCCT 60 TCCCTGCAGC CGGTCCTCTT CGCCCTTGTC CTCCTGTGCT ACCTCCTGAC CTTGACGGGC 120 AACTCGGCGC TGGTGCTGCT GGCGGTGCGC GACCCGCGCC TGCACACGCC CATGTACTAC 180 TTCCTCTGCC ACCTGGCCTT GGTAGACGCG GGCTTCACTA CTAGCGTGGT GCCGCCGCTG 240 CTGGCCAACC TGCGCGGACC AGCGCTCTGG CTGCCGCGCA GCCACTGCAC GGCCCAGCTG 300 TGCGCATCGC TGGCTCTGGG TTCGGCCGAA TGCGTCCTCC TGGCGGTGAT GGCTCTGGAC 360 CGCGCGGCCG CAGTGTGCCG CCCGCTGCGC TATGCGGGGC TCGTCTCCCC GCGCCTATGT 420 CGCACGCTGG CCAGCGCCTC CTGGCTAAGC GGCCTCACCA ACTCGGTTGC GCAAACCGCG 480 CTCCTGGCTG AGCGGCCGCT GTGCGCGCCC CGCCTGCTGG ACCACTTCAT CTGTGAGCTG 540 CCGGCGTTGC TCAAGCTGGC CTGCGGAGGC GACGGAGACA CTACCGAGAA CCAGATGTTC 600 GCCGCCCGCG TGGTCATCCT GCTGCTGCCG TTTGCCGTCA TCCTGGCCTC CTACGGTGCC 660 GTGGCCCGAG CTGTCTGTTG CATGCGGTTC AGCGGAGGCC GGAGGAGGGC GGTGGGCACG 720 TGTGGGTCCC ACCTGACAGC CGTCTGCCTG TTCTACGGCT CGGCCATCTA CACCTACCTG 780 CAGCCCGCGC AGCGCTACAA CCAGGCACGG GGCAAGTTCG TATCGCTCTT CTACACCGTG 840 GTCACACCTG CTCTCAACCC GCTCATCTAC ACCCTCAGGA ATAAGAAAGT GAAGGGGGCA 900 GCGAGGAGGC TGCTGCGGAG TCTGGGGAGA GGCCAGGCTG GGCAGTGA Seq ID NO : 25 DNA Sequence Nucleic Acid Accession # : Nom 018685. 1 Coding sequence : 156.. 3533 1 11 21 31 41 51 CTGGAAGCCG AGAGGAGAGG ACAGCTGGTT GTGGGAGAGT TCCCCCGCCT CAGACTCCTG 60 GTTTTTTCCA GGAGACACAC TGAGCTGAGA CTCACTTTTC TCTTCCTGAA TTTGAACCAC 120 CGTTTCCATC GTCTCGTAGT CCGACGCCTG GGGCGATGGA TCCGTTTACG GAGAAACTGC 180 TGGAGCGAAC CCGTGCCAGG CGAGAGAATC TTCAGAGAAA AATGGCTGAG AGGCCCACAG 240 CAGCTCCAAG GTCTATGACT CATGCTAAGC GAGCTAGACA GCCACTTTCA GAAGCAAGTA 300 ACCAGCAGCC CCTCTCTGGT GGTGAAGAGA AATCTTGTAC AAAACCATCG CCATCAAAAA 360 AACGCTGTTC TGACAACACT GAAGTAGAAG TTTCTAACTT GGAAAATAAA CAACCAGTTG 420 AGTCGACATC TGCAAAATCT TGTTCTCCAA GTCCTGTGTC TCCTCAGGTG CAGCCACAAG 480 CAGCAGATAC CATCAGTGAT TCTGTTGCTG TCCCGGCATC ACTGCTGGGC ATGAGGAGAG 540 GGCTGAACTC AAGATTGGAA GCAACTGCAG CCTCCTCAGT TAAAACACGT ATGCAAAAAC 600 TTGCAGAGCA ACGGCGCCGT TGGGATAATG ATGATATGAC AGATGACATT CCTGAAAGCT 660 CACTCTTCTC ACCAATGCCA TCAGAGGAAA AGGCTGCTTC CCCTCCCAAA CCTCTGCTTT 720 CAAATGCCTC GGCAACTCCA GTTGGCAGAA GGGGCCGTCT GGCCAATCTT GCTGCAACTA 780 TTTGCTCCTG GGAAGATGAT GTAAATCACT CATTTGCAAA ACAAAACAGT GTACAAGAAC 840 AGCCTGGTAC CGCTTGTTTA TCCAAATTTT CCTCTGCAAG TGGAGCATCT GCTAGGATCA 900 ATAGCAGCAG TGTTAAGCAG GAAGCTACAT TCTGTTCCCA AAGGGATGGC GATGCCTCTT 960 TGAATAAAGC CCTATCCTCA AGTGCTGATG ATGCGTCTTT GGTTAATGCC TCAATTTCCA 1020 GCTCTGTGAA AGCTACTTCT TCTCCAGTGA AATCTACTAC ATCTATCACT GATGCTAAAA 1080 GTTGTGAGGG ACAAAATCCT GAGCTACTTC CAAAAACTCC TATTAGTCCT CTGAAAACGG 1140 GGGTATCGAA ACCAATTGTG AAGTCAACTT TATCCCAGAC AGTTCCATCC AAGGGAGAAT 1200 TAAGTAGAGA AATTTGTCTG CAATCTCAAT CTAAAGACAA ATCTACGACA CCAGGAGGAA 1260 CAGGAATTAA GCCTTTCCTG GAACGCTTTG GAGAGCGTTG TCAAGAACAT AGCAAAGAAA 1320 GTCCAGCTCG TAGCACACCC CACAGAACCC CCATTATTAC TCCAAATACA AAGGCCATCC 1380 AAGAAAGATT ATTCAAGCAA GACACATCTT CATCTACTAC CCATTTAGCA CAACAGCTCA 1440 AGCAGGAACG TCAAAAAGAA CTAGCATGTC TTCGTGGCCG ATTTGACAAG GGCAATATAT 1500 GGAGTGCAGA AAAAGGCGGA AACTCAAAAA GCAAACAACT AGAAACCAAA CAGGAAACTC 1560 ACTGTCAGAG CACTCCCCTC AAAAAACACC AAGGTGTTTC AAAAACTCAG TCACTTCCAG 1620 TAACAGAAAA GGTGACCGAA AACCAGATAC CAGCCAAAAA TTCTAGTACA GAACCTAAAG 1680 GTTTCACTGA ATGCGAAATG ACGAAATCTA GCCCTTTGAA AATAACATTG TTTTTAGAAG 1740 AGGACAAATC CTTAAAAGTA ACATCAGACC CAAAGGTTGA GCAGAAAATT GAAGTGATAC 1800 GTGAAATTGA GATGAGTGTG GATGATGATG ATATCAATAG TTCGAAAGTA ATTAATGACC 1860 TCTTCAGTGA TGTCCTAGAG GAAGGTGAAC TAGATATGGA GAAGAGCCAA GAGGAGATGG 1920 ATCAAGCATT AGCAGAAAGC AGCGAAGAAC AGGAAGATGC ACTGAATATC TCCTCAATGT 1980 CTTTACTTGC ACCATTGGCA CAAACAGTTG GTGTGGTAAG TCCAGAGAGT TTAGTGTCCA 2040 CACCTAGACT GGAATTGAAA GACACCAGCA GAAGTGATGA AAGTCCAAAA CCAGGAAAAT 2100 TCCAAAGAAC TCGTGTCCCT CGAGCTGAAT CTGGTGATAG CCTTGGTTCT GAAGATCGTG 2160 ATCTTCTTTA CAGCATTGAT GCATATAGAT CTCAAAGATT CAAAGAAACA GAACGTCCAT 2220 CAATAAAGCA GGTGATTGTT CGGAAGGAAG ATGTTACTTC AAAACTGGAT GAAAAAAATA 2280 ATGCCTTTCC TTGTCAAGTT AATATCAAAC AGAAAATGCA GGAACTCAAT AACGAAATAA 2340 ATATGCAACA GACAGTGATC TATCAAGCTA GCCAGGCTCT TAACTGCTGT GTTGATGAAG 2400 AACATGGAAA AGGGTCCCTA GAAGAAGCTG AAGCAGAAAG ACTTCTTCTA ATTGCAACTG 2460 GGAAGAGAAC ACTTTTGATT GATGAATTGA ATAAATTGAA GAACGAAGGA CCTCAGAGGA 2520 AGAATAAGGC TAGTCCCCAA AGTGAATTTA TGCCATCCAA AGGATCAGTT ACTTTGTCAG 2580 AAATCCGCTT GCCTCTAAAA GCAGATTTTG TCTGCAGTAC GGTTCAGAAA CCAGATGCAG 2640 CAAATTACTA TTACTTAATT ATACTAAAAG CAGGAGCTGA AAATATGGTA GCCACACCAT 2700 TAGCAAGTAC TTCAAACTCT CTTAACGGTG ATGCTCTGAC ATTCACTACT ACATTTACTC 2760 TGCAAGATGT ATCCAATGAC TTTGAAATAA ATATTGAAGT TTACAGCTTG GTGCAAAAGA 2820 AAGATCCCTC AGGCCTTGAT AAGAAGAAAA AAACATCCAA GTCCAAGGCT ATTACTCCAA 2880 AGCGACTCCT CACATCTATA ACCACAAAAA GCAACATTCA TTCTTCAGTC ATGGCCAGTC 2940 CAGGAGGTCT TAGTGCTGTG CGAACCAGCA ACTTCGCCCT TGTTGGATCT TACACATTAT 3000 CATTGTCTTC AGTAGGAAAT ACTAAGTTTG TTCTGGACAA GGTCCCCTTT TTATCTTCTT 3060 TGGAAGGTCA TATTTATTTA AAAATAAAAT GTCAAGTGAA TTCCAGTGTT GAAGAAAGAG 3120 GTTTTCTAAC CATATTTGAA GATGTTAGTG GTTTTGGTGC CTGGCATCGA AGATGGTGTG 3180 TTCTTTCTGG AAACTGTATA TCTTATTGGA CTTATCCAGA TGATGAGAAA CGCAAGAATC 3240 CCATAGGAAG GATAAATCTG GCTAATTGTA CCAGTCGTCA GATAGAACCA GCCAACAGAG 3300 AATTTTGTGC AAGACGCAAC ACTTTTGAAT TAATTACTGT CCGACCACAA AGAGAAGATG 3360 ACCGAGAGAC TCTTGTCAGC CAATGCAGGG ACACACTCTG TGTTACCAAG AACTGGCTGT 3420 CTGCAGATAC TAAAGAAGAG CGGGATCTCT GGATGCAAAA ACTCAATCAA GTTCTTGTTG 3480 ATATTCGCCT CTGGCAACCT GATGCTTGCT ACAAACCTAT TGGAAAGCCT TAAACCGGGA 3540 AATTTCCATG CTATCTAGAG GTTTTTGATG TCATCTTAAG AAACACACTT AAGAGCATCA 3600 GATTTACTGA TTGCATTTTA TGCTTTAAGT ACGAAAGGGT TTGTGCCAAT ATTCACTACG 3660

TATTATGCAG TATTTATATC TTTTGTATGT AAAACTTTAA CTGATTTCTG TCATTCATCA 3720 ATGAGTAGAA GTAAATACAT TATAGTTGAT TTTGCTAAAT CTTAATTTAA AAGCCTCATT 3780 TTCCTAGAAA TCTAATTATT CAGTTATTCA TGACAATATT TTTTTAAAAG TAAGAAATTC 3840 TGAGTTGTCT TCTTGGAGCT GTAGGTCTTG AAGCAGCAAC GTCTTTCAGG GGTTGGAGAC 3900 AGAAACCCAT TCTCCAATCT CAGTAGTTTT TTCGAAAGGC TGTGATCATT TATTGATCGT 3960 GATATGACTT GTTACTAGGG TACTGAAAAA AATGTCTAAG GCCTTTACAG AAACATTTTT 4020 AGTAATGAGG ATGAGAACTT TTTCAAATAG CAAATATATA TTGGCTTAAA GCATGAGGCT 4080 GTCTTCAGAA AAGTGATGTG GACATAGGAG GCAATGTGTG AGACTTGGGG GTTCAATATT 4140 TTATATAGAA GAGTTAATAA GCACATGGTT TACATTTACT CAGCTACTAT ATATGCAGTG 4200 TGGTGCACAT TTTCACAGAA TTCTGGCTTC ATTAAGATCA TTATTTTTGC TGCGTAGCTT 4260 ACAGACTTAG CATATTAGTT TTTTCTACTC CTACAAGTGT AAATTGAAAA ATCTTTATAT 4320 TAAAAAAGTA AACTGTTATG AAGCTGCTAT GTACTAATAA TACTTTGCTT GCCAAAGTGT 4380 TTGGGTTTTG TTGTTGTTTG TTTGTTTGTT TGTTTTTGGT TCATGAACAA CAGTGTCTAG 4440 AAACCCATTT TGAAAGTGGA AAATTATTAA GTCACCTATC ACCTTTAAAC GCCTTTTTTT 4500 AAAATTATAA AATATTGTAA AGCAGGGTCT CAACTTTTAA ATACACTTTG AACTTCTTCT 4560 CTGAATTATT AAAGTTCTTT ATGACCTCAT TTATAAACAC TAAATTCTGT CACCTCCTGT 4620 CATTTTATTT TTTATTCATT CAAATGTATT TTTTCTTGTG CATATTATAA AAATATATTT 4680 TATGAGCTCT TACTCAAATA AATACCTGTA AATGTCTAAA GG 4722 Seq ID NO : 26 DNA Sequence Nucleic Acid Accession # : NM_018098. 4 Coding sequence : 29.. 2680 1 11 21 31 41 51 AGAGTGCTGA TTTAGAAGAA TACAAATCAT GGCTGAAAAT AGTGTATTAA CATCCACTAC 60 TGGGAGGACT AGCTTGGCAG ACTCTTCCAT TTTTGATTCT AAAGTTACTG AGATTTCCAA 120 GGAAAACTTA CTTATTGGAT CTACTTCATA TGTAGAAGAA GAGATGCCTC AGATTGAAAC 180 AAGAGTGATA TTGGTTCAAG AAGCTGGAAA ACAAGAAGAA CTTATAAAAG CCTTAAAGGA 240 CATTAAAGTG GGCTTTGTAA AGATGGAGTC AGTGGAAGAA TTTGAAGGTT TGGATTCTCC 300 GGAATTTGAA AATGTATTTG TAGTCACGGA CTTTCAGGAT TCTGTCTTTA ATGACCTCTA 360 CAAGGCTGAT TGTAGAGTTA TTGGACCACC AGTTGTATTA AATTGTTCAC AAAAAGGAGA 420 GCCTTTGCCA TTTTCATGTC GCCCGTTGTA TTGTACAAGT ATGATGAATC TAGTACTATG 480 CTTTACTGGA TTTAGGAAAA AAGAAGAACT AGTCAGGTTG GTGACATTGG TCCATCACAT 540 GGGTGGAGTT ATTCGAAAAG ACTTTAATTC AAAAGTTACA CATTTGGTGG CAAATTGTAC 600 ACAAGGAGAA AAATTCAGGG TTGCTGTGAG TCTAGGTACT CCAATTATGA AGCCAGAATG 660 GATTTATAAA GCTTGGGAAA GGCGGAATGA ACAGGATTTC TATGCAGCAG TTGATGACTT 720 TAGAAATGAA TTTAAAGTTC CTCCATTTCA AGATTGTATT TTAAGTTTCC TGGGATTTTC 780 AGATGAAGAG AAAACCAATA TGGAAGAAAT GACTGAAATG CAAGGAGGTA AATATTTACC 840 GCTTGGAGAT GAAAGATGCA CTCACCTTGT AGTTGAAGAG AATATAGTAA AAGATCTTCC 900 CTTTGAACCT TCAAAGAAAC TTTATGTTGT CAAGCAAGAG TGGTTCTGGG GAAGCATTCA 960 AATGGATGCC CGAGCTGGAG AAACTATGTA TTTATATGAA AAGGCAAATA CTCCTGAGCT 1020 CAAGAAATCA GTGTCAATGC TTTCTCTAAA TACCCCTAAC AGCAATCGCA AACGACGTCG 1080 TTTAAAAGAA ACACTTGCTC AGCTTTCAAG AGAGACAGAC GTGTCACCAT TTCCACCCCG 1140 TAAGCGCCCA TCAGCTGAGC ATTCCCTTTC CATAGGGTCA CTCCTAGATA TCTCCAACAC 1200 ACCAGAGTCT AGCATTAACT ATGGAGACAC CCCAAAGTCT TGTACTAAGT CTTCTAAAAG 1260 CTCCACTCCA GTTCCTTCAA AGCAGTCAGC AAGGTGGCAA GTTGCAAAAG AGCTTTATCA 1320 AACTGAAAGT AATTATGTTA ATATATTGGC AACAATTATT CAGTTATTTC AAGTACCATT 1380 GGAAGAGGAA GGACAACGTG GTGGACCTAT CCTTGCACCA GAGGAGATTA AGACTATTTT 1440 TGGTAGCATC CCAGATATCT TTGATGTACA CACTAAGATA AAGGATGATC TTGAAGACCT 1500 TATAGTTAAT TGGGATGAGA GCAAAAGCAT TGGTGACATT TTTCTGAAAT ATTCAAAAGA 1560 TTTGGTAAAA ACCTACCCTC CCTTTGTAAA CTTCTTTGAA ATGAGCAAGG AAACAATTAT 1620 TAAATGTGAA AAACAGAAAC CAAGATTTCA TGCTTTTCTC AAGATAAACC AAGCAAAACC 1680 AGAATGTGGA CGGCAGAGCC TTGTTGAACT TCTTATCCGA CCAGTACAGA GGTTACCCAG 1740 TGTTGCATTA CTTTTAAATG ATCTTAAGAA GCATACAGCT GATGAAAATC CAGACAAAAG 1800 CACTTTAGAA AAAGCTATTG GATCACTGAA GGAAGTAATG ACGCATATTA ATGAGGATAA 1860 GAGAAAAACA GAAGCTCAAA AGCAAATTTT TGATGTTGTT TATGAAGTAG ATGGATGCCC 1920 AGCTAATCTT TTATCTTCTC ACCGAAGCTT AGTACAGCGG GTTGAAACAA TTTCTCTAGG 1980 TGAGCACCCC TGTGACAGAG GAGAACAAGT AACTCTCTTC CTCTTCAATG ATTGCCTAGA 2040 GATAGCAAGA AAACGGCACA AGGTTATTGG CACTTTTAGG AGTCCTCATG GCCAAACCCG 2100 ACCCCCAGCT TCTCTTAAGC ATATTCACCT AATGCCTCTT TCTCAGATTA AGAAGGTATT 2160 GGACATAAGA GAGACAGAAG ATTGCCATAA TGCTTTTGCC TTGCTTGTGA GGCCACCAAC 2220 AGAGCAGGCA AATGTGCTAC TCAGTTTCCA GATGACATCA GATGAACTTC CAAAAGAAAA 2280 CTGGCTAAAG ATGCTGTGTC GACATGTAGC TAACACCATT TGTAAAGCAG ATGCTGAGAA 2340 TCTTATTTAT ACTGCTGATC CAGAATCCTT TGAAGTAAAT ACAAAAGATA TGGACAGTAC 2400 ATTGAGTAGA GCATCAAGAG CAATAAAAAA GACTTCAAAA AAGGTTACAA GAGCATTCTC 2460 TTTCTCCAAA ACTCCAAAAA GAGCTCTTCG AAGGGCTCTT ATGACATCCC ACGGCTCAGT 2520 GGAGGGAAGA AGTCCTTCCA GCAATGATAA GCATGTAATG AGTCGTCTTT CTAGCACATC 2580 ATCATTAGCA GGTATCCCTT CTCCCTCCCT TGTCAGCCTT CCTTCCTTCT TTGAAAGGAG 2640 AAGTCATACG TTAAGTAGAT CTACAACTCA TTTGATATGA AGCGTTACCA AAATCTTAAA 2700 TTATAGAAAT GTATAGACAC CTCATACTCA AATAAGAAAC TGACTTAAAT GGTACTTGTA 2760 ATTAGCACTT GGTGAAAGCT GGAAGGAAGA TAAATAACAC TAAACTATGC TATTTGATTT 2820 TTCTTCTTGA AAGAGTAAGG TTTACCTGTT ACATTTTCAA GTTAATTCAT GTAAAAAATG 2880 ATAGTGATTT TGATGTAATT TATCTCTTGT TTGAATCTGT CATTCAAAGG CCAATAATTT 2940 AAGTTGCTAT CAGCTGATAT TAGTAGCTTT GCAACCCTGA TAGAGTAAAT AAATTTTATG 3000 GGCGGGTGCC AAATACTGCT GTGAATCTAT TTGTATAGTA TCCATGAATG AATTTATGGA 3060 AATAGATATT TGTGCAGCTC AATTTATGCA GAGATTAAAT GACATCATAA TACTGGATGA 3120 AAACTTGCAT AGAATTCTGA TTAAATAGTG GGTCTGTTTC ACATGTGCAG TTTGAAGTAT 3180 TTAAATAACC ACTCCTTTCA CAGTTTATTT TCTTCTCAAG CGTTTTCAAG ATCTAGCATG 3240 TGGATTTTAA AAGATTTGCC CTCATTAACA AGAATAACAT TTAAAGGAGA TTGTTTCAAA 3300 ATATTTTTGC AAATTGAGAT AAGGACAGAA AGATTGAGAA ACATTGTATA TTTTGCAAAA 3360 ACAAGATGTT TGTAGCTGTT TCAGAGAGAG TACGGTATAT TTATGGTAAT TTTATCCACT 3420 AGCAAATCTT GATTTAGTTT GATAGTGTGT GGAATTTTAT TTTGAAGGAT AAGACCATGG 3480 GAAAATTGTG GTAAAGACTG TTTGTACCCT TCATGAAATA ATTCTGAAGT TGCCATCAGT 3540 TTTACTAATC TTCTGTGAAA TGCATAGATA TGCGCATGTT CAACTTTTTA TTGTGGTCTT 3600

ATAATTAAAT GTAAAATTGA AAATTCATTT GCTGTTTCAA AGTGTGATAT CTTTCACAAT 3660 AGCCTTTTTA TAGTCAGTAA TTCAGAATAA TCAAGTTCAT ATGGATAAAT GCATTTTTAT 3720 TTCCTATTTC TTTAGGGAGT GCTACAAATG TTTGTCACTT AAATTTCAAG TTTCTGTTTT 3780 AATAGTTAAC TGACTATAGA TTGTTTTCTA TGCCATGTAT GTGCCACTTC TGAGAGTAGT 3840 AAATGACTCT TTGCTACATT TTAAAAGCAA TTGTATTAGT AAGAACTTTG TAAATAAATA 3900 CCTAAAACCC AAGTGT 3916 Seq ID NO : 27 DNA Sequence Nucleic Acid Accession # : NM_002497. 1 Coding sequence : 135.. 1472 1 11 21 31 41 51 GGCACGAGTA GGGGTGGCGG GTCAGTGCTG CTCGGGGGCT TCTCCATCCA GGTCCCTGGA 60 GTTCCTGGTC CCTGGAGCTC CGCACTTGGC GCGCAACCTG CGTGAGGCAG CGCGACTCTG 120 GCGACTGGCC GGCCATGCCT TCCCGGGCTG AGGACTATGA AGTGTTGTAC ACCATTGGCA 180 CAGGCTCCTA CGGCCGCTGC CAGAAGATCC GGAGGAAGAG TGATGGCAAG ATATTAGTTT 240 GGAAAGAACT TGACTATGGC TCCATGACAG AAGCTGAGAA ACAGATGCTT GTTTCTGAAG 300 TGAATTTGCT TCGTGAACTG AAACATCCAA ACATCGTTCG TTACTATGAT CGGATTATTG 360 ACCGGACCAA TACAACACTG TACATTGTAA TGGAATATTG TGAAGGAGGG GATCTGGCTA 420 GTGTAATTAC AAAGGGAACC AAGGAAAGGC AATACTTAGA TGAAGAGTTT GTTCTTCGAG 480 TGATGACTCA GTTGACTCTG GCCCTGAAGG AATGCCACAG ACGAAGTGAT GGTGGTCATA 540 CCGTATTGCA TCGGGATCTT AAACCAGCCA ATGTTTTCCT GGATGGCAAG CAAAACGTCA 600 AGCTTGGAGA CTTTGGGCTA GCTAGAATAT TAAACCATGA CACGAGTTTT GCAAAAACAT 660 TTGTTGGCAC ACCTTATTAC ATGTCTCCTG AACAAATGAA TCGCATGTCC TACAATGAGA 720 AATCAGATAT CTGGTCATTG GGCTGCTTGC TGTATGAGTT ATGTGCATTA ATGCCTCCAT 780 TTACAGCTTT TAGCCAGAAA GAACTCGCTG GGAAAATCAG AGAAGGCAAA TTCAGGCGAA 840 TTCCATACCG TTACTCTGAT GAATTGAATG AAATTATTAC GAGGATGTTA AACTTAAAGG 900 ATTACCATCG ACCTTCTGTT GAAGAAATTC TTGAGAACCC TTTAATAGCA GATTTGGTTG 960 CAGACGAGCA AAGAAGAAAT CTTGAGAGAA GAGGGCGACA ATTAGGAGAG CCAGAAAAAT 1020 CGCAGGATTC CAGCCCTGTA TTGAGTGAGC TGAAACTGAA GGAAATTCAG TTACAGGAGC 1080 GAGAGCGAGC TCTCAAAGCA AGAGAAGAAA GATTGGAGCA GAAAGAACAG GAGCTTTGTG 1140 TTCGTGAGAG ACTAGCAGAG GACAAACTGG CTAGAGCAGA AAATCTGTTG AAGAACTACA 1200 GCTTGCTAAA GGAACGGAAG TTCCTGTCTC TGGCAAGTAA TCCAGAACTT CTTAATCTTC 1260 CATCCTCAGT AATTAAGAAG AAAGTTCATT TCAGTGGGGA AAGTAAAGAG AACATCATGA 1320 GGAGTGAGAA TTCTGAGAGT CAGCTCACAT CTAAGTCCAA GTGCAAGGAC CTGAAGAAAA 1380 GGCTTCACGC TGCCCAGCTG CGGGCTCAAG CCCTGTCAGA TATTGAGAAA AATTACCAAC 1440 TGAAAAGCAG ACAGATCCTG GGCATGCGCT AGCCAGGTAG AGAGACACAG AGCTGTGTAC 1500 AGGATGTAAT ATTACCAACC TTTAAAGACT GATATTCAAA TGCTGTAGTG TTGAATACTT 1560 GGCCCCATGA GCCATGCCTT TCTGTATAGT ACACATGATA TTTCGGAATT GGTTTTACTG 1620 TTCTTCAGCA ACTATTGTAC AAAATGTTCA CATTTAATTT TTCTTTCTTC TTTTAAGAAC 1680 ATATTATAAA AAGAATACTT TCTTGGTTGG GCTTTTAATC CTGTGTGTGA TTACTAGTAG 1740 GAACATGAGA TGTGACATTC TAAATCTTGG GAGAAAAAAT AATATTAGGA AAAAAATATT 1800 TATGCAGGAA GAGTAGCACT CACTGAATAG TTTTAAATGA CTGAGTGGTA TGCTTACAAT 1860 TGTCATGTCT AGATTTAAAT TTTAAGTCTG AGATTTTAAA TGTTTTTGAG CTTAGAAAAC 1920 CCAGTTAGAT GCAATTTGGT CATTAATACC ATGACATCTT GCTTATAAAT ATTCCATTGC 1980 TCTGTAGTTC AAATCTGTTA GCTTTGTGAA AATTCATCAC TGTGATGTTT GTATTCTTTT 2040 TTTTTTTCTG TTTAACAGAA TATGAGCTGT CTGTCATTTA CCTACTTCTT TCCCACTAAA 2100 TAAAAGAATT CTTCAGTTA 2119 Seq ID NO : 28 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 GGGAGCTACA ATGTTTTGTC ATTATTCACT CTGATGTGAA AAAGGCAGTG AATTTAATAG 60 AAAATAACTT CGTAGAGCAA AATCTCAGGT GTGTTTTTTT AGTGCCGCAG TCTTGGATGA 120 TGGGTTCCTA GAAGCTCTCA ACATCTCTTC TTAATTGGAG AAAGTGTTAA GCCCCAAAGT 180 AGCTGGAGCA GTACATCTTC AATTTTTGAC AAGAAAACAG GAACTTGATT ACTTTGAGTG 240 CTATTCATTA GTTTCTGCTT TCATTGAGAA TGCAACAAAA GCCAACTAGG CTGCTGCTAA 300 CTCCTTGCNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 360 CTAGGGAGTC TTTCATCTTG AGTGACTCT GCACAAATGA TCTTCAAAGC ATTTTAGCCA 420 CCAGAGGAAT TCTCTTGAAA TACCCAAAAT CCATCAGTAT CTTGAATCAT GCTGGATTTT 480 GAAGAATTCT TAACAAGCCA TGTAAAGGGG GCTCTCTGGC CTTGAAATAG TGATGTTTTT 540 TATACAGAAA GGAGAATGCA GAATGGTCAG ACTACCATGC ACTGTTAAAT TTGATTTCAA 600 GAAATTACAG GAAAACTTTC CAAAGTTCCA TCTCACAGAA ATTATTTTTA CAAAGAATTC 660 CAAGATAAGT TTAGTTTTAT GGAAGACTTT TATGTGGTTT TTACTCACTC TTCATCTCAG 720- ACATCAACAG ATGATTACAT CACTTATTTA GCTAGTAAAT TTATTAATAT AAAAACTCAG 780 AGACATTCCA ATATCCACAT TGCTTACACC ATTAGGCATA GATTCAGTGT CAGCTATGAC 840 AATTGAAAAT AAGCTGTTTT GTGATTTAAA GGTTTAAATT TCTCTAACCA AACTGCTTGA 900 TCCAGATGCA GGACTGCAAA TGTTAATATT TGTTCTGGAA GAACAATCAA ATAAGACTTA 960 AGAGGAAAAG GAATGGCCAC AATCCACCTG AAATTTTTTT TTAAAAAGTG TGCAGCCTAC 1020 TAAATCAGAA TGAAAATAGA AGTACAAGAT TATAAACAAA ATGCAATCAA ACTTTTCTTA 1080 AGCTTACCTA AAGTTATTTC ATCTGAAAAT TTCAAGCAAC TTTGTTCAAC ATTAAATTGA 1140 CAATCTAAAC TAACAAGTCT TTTGAATTTA TGCATGGTAG TAAACATTCT CTCTATTAAC 1200 TGTATTACCT AAGGCTAAAC CTAAAATTTT TAAGCAAAAT TAGAAAAATA GTCTTCACTC 1260 ATCAAAAAAT AAAGTTTGTT ACATTTAGTA TTTTCCCAAG AAAAAAAAAA AAAAAAAAAA 1320 AAAAAAAAAA AGAGTCTGTG CAAAATGTCA CTAAAAATAA ATTAGCACTA GAAATTATTT 1380 CTAAATACCA AAAAAAAAAA AAAATTGAGA TGGGTTTCCC AAGGAAAACA CTCGCAATCA 1440 AACAACAAAA ACAAAGAACA AAAAAGAATA GACAAAAAGA 1480 Seq ID NO : 29 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TCCCTGCAGC TGTGTTTGAA CAGGTCATTT ACCATGCTGT CCTCCAGGTT CAACAGTATG 60

GCTCCAAAGG ATGAAATTTC ATTCTGATTT TCTGGCTGAA GACTATTCTC TTTGTGTATG 120 TCCACCACAG TTACTTTATC CCTTCATCTG TGGATGGGCA GGAAACTCCA AACTGTCCAA 180 GGAGATAGTT CTGTTGTGAT TACTTCATTG AGAAATTTAA CTTATGAGCA GTTGAAAGGA 240 ATGCAAGTTG CTGCAAAATC AGAATGAAGA GTGCAAAACG ASSRAGCTAC AATGTTTTGT 300 CATTATTCAC TCTGATGTGA AAAAGGCAGT GAATTTAATA GAAAATAACT TCGTAGAGYA 360 AAATCTCAGG TGTGTTTTTT TAGTGCCGCA GTCTTGGATG ATGGGTTCCT AGAAGCTCTC 420 AAACATCTCT TCTTAATTGG AGAAAGTGTT AAGCCCCAAA GTAGCTGGAG CAGTACATCT 480 TCAATTTTTG ACAAGAAAGC AGGAACTTGA TTACTTTGAG TGCTATTCAT TAGTTTCTGC 540 TTTCATTGAG AATGCAACAA AAGCCAACTA GGCTGCTGCT AACTCCTTGC TGGACTTCTT 600 CTGCCACTGT CACAGGAACT GTAATCTCAC TGGACAATTA ACTAGGGAGT CTTTCATCTT 660 GAGTGACTGC TGCACAAATG ATCTTCAAAG CATTTTAGCC ACCAGAGGAA TTCTCTTGAA 720 ATACCCAAAA TCCATCAGTA TCTTGAATCA TGCTGGATTT TGAAGAATTC TTAACAAGCC 780 ATGTAAAGGG GGCTCTCTGG CCTTGAAATA GTGATGTTTT TTATACAGAA AGGAGAATGC 840 AGAATGGTCA GACTACCATG CACTGTTAAA TTTGATTTCA AGAAATTACA GGAAAACTTT 900 CCAAAGTTCC ATCTCACAGA AATTATTTTT ACAAAGAATT CCAAGATAAG TTTAGTTTTA 960 TGGAAGACTT TTATGTGGTT TTTACTCACT CTTCATCTCA GACATCAACA GATGATTACA 1020 TCACTTATTT AGCTAGTAAA TTTATTAATA TAAAAACTCA GAGACATTCC AATATCCACA 1080 TTGCTTACAC CATTAGGCAT AGATTCAGTG TCAGCTATGA CAATTGAAAA TAAGCTGTTT 1140 TGTGATTTAA AGGTTTAAAT TTCTCTAACC AAACTGCTTG ATCCAGATGC AGGACTGCAA 1200 ATGTTAATAT TTGTTCTGGA AGAACAATCA AATAAGACTT AAGAGGAAAA GGAATGGCCA 1260 CAATCCACCT GAAAATTTTT TTTTAAAAAG TGTGCAGCCT ACTAAATCAG AATGAAAATA 1320 GAAGTACAAG ATTATAAACA AAATGCAATC AAACTTTTCT TAAGCTTACC TAAAGTTATT 1380 TCATCTGAAA ATTTCAAGCA ACTTTGTTCA ACATTAAATT GACAATCTAA ACTAACAAGT 1440 CTTTTGAATT TATGCATGGT AGTAAACATT CTCTCTATTA ACTTTATTAC CTAAGGCTAA 1500 ACCTAAAATT TTTAAGCAAA ATTAGAAAAA TAGTCTTCAC TCATCAAAAA ATAAAGTTTG 1560 TTACATTTAG TATTTTCCCA AT 1582 Seq ID NO : 30 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence :.. 817 1 11 21 31 41 51 1 1 1 1 1 1 AGATATATCA TACGAAAATG AAAATTATAA TTCTTCTTGG ATTCCTGGGA GCCACATTGT 60 CAGCCCCAGT TTACTTCTTA ATCTTAATAA TGGTCAACTT TTGCCACTAC AACTTCAGGG 120 CCCACTTAAT TCATGGATTC CACCTTTCTC TGGAATTTTA CAACAGCAGC AGCAGGCTCA 180 AATTCCAGGA CTCTCCCAGT TCTCTTTATC AGCTCTAGAC CAGTTTGCTG GACTGCTCCC 240 AAATCAGATA CCCTTAACAG GAGAGGCCAG TTTTGCCCAA GGAGCCCAGG CAGGCCAAGT 300 TGATCCCTTA CAGCTTCAAA CACCGCCTCA GACACAACCA GGCCCCAGTC ACGTGATGCC 360 CTATGTATTC TCCTTCAAAA TGCCTCAAGA GCAAGGACAG ATGTTTCAAT ACTATCCAGT 420 TTACATGGTC CTACCCTGGG AACAACCTCA GCAAACAGTT CCAAGGTCAC CTCAACAAAC 480 AAGACAGCAA CAGTATGAGG AGCAGATACC ATTCTATGCT CAATTTGGAT ACATTCCACA 540 ACTAGCAGAA CCTGCTATAT CAGGAGGACA GCAGCAACTA GCTTTTGATC CCCAACTAGG 600 CACAGCTCCT GAAATTGCTG TGATGTCAAC AGGAGAAGAG ATACCATATT TACAAAAAGA 660 AGCGATCAAC TTTAGACATG ACAGTGCAGG AGTTTTCATG CCCTCAACTT CACCAAAACC 720 CAGCACAACC AATGTTTTCA CTTCTGCTGT AGACCAAACT ATTACCCCAG AGCTCCCAGA 780 AGAGAAGGAC AAGACTGACA GCCTAAGGGA ACCATAA 817 Seq ID NO : 31 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence :.. 917 1 11 21 31 41 51 AGAGAGGAAA AGAACACAGA TCTCGCATGG TTCAGATTTT TCTTTTTAGG TCCAGGAGTA 60 AGATATATCA TACGAAAATG AAAATTATAA TTCTTCTTGG ATTCCTGGGA GCCACATTGT 120 CAGCCCCACT TATCCCACAG CGTCTCATGT CTGCCAGCAA TAGCAATGAG TTACTTCTTA 180 ATCTTAATAA TGGTCAACTT TTGCCACTAC AACTTCAGGG CCCACTTAAT TCATGGATTC 240 CACCTTTCTC TGGAATTTTA CAACAGCAGC AGCAGGCTCA AATTCCAGGA CTCTCCCAGT 300 TCTCTTTATC AGCTCTAGAC CAGTTTGCTG GACTGCTCCC AAATCAGATA CCCTTAACAG 360 GAGAGGCCAG TTTTGCCCAA GGAGCCCAGG CAGGCCAAGT TGATCCCTTA CAGCTTCAAA 420 CACCGCCTCA GACACAACCA GGCCCCAGTC ACGTGATGCC CTATGTATTC TCCTTCAAAA 480 TGCCTCAAGA GCAAGGACAG ATGTTTCAAT ACTATCCAGT TTACATGGTC CTACCCTGGG 540 AACAACCTCA GCAAACAGTT CCAAGGTCAC CTCAACAAAC AAGACAGCAA CAGTATGAGG 600 AGCAGATACC ATTCTATGCT CAATTTGGAT ACATTCCACA ACTAGCAGAA CCTGCTATAT 660 CAGGAGGACA GCAGCAACTA GCTTTTGATC CCCAACTAGG CACAGCTCCT GAAATTGCTG 720 TGATGTCAAC AGGAGAAGAG ATACCATATT TACAAAAAGA AGCGATCAAC TTTAGACATG 780 ACAGTGCAGG AGTTTTCATG CCCTCAACTT CACCAAAACC CAGCACAACC AATGTTTTCA 840 CTTCTGCTGT AGACCAAACT ATTACCCCAG AGCTCCCAGA AGAGAAGGAC AAGACTGACA 900 GCCTAAGGGA ACCATAA 917 Seq ID NO : 32 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TTTTTTTTTT TTTTTGTAGA GATGGGGTCT CACTTTGTTG CCCATGCTTT GGCTGCTCTT 60 CAAGATTTAG CACTTCTGAG CTGTTGCTTT TGTCTCCAGT CTACCCTGAG CAGTTCTTAA 120 GGTGTTTGAA GCAGAAGAAA GAGAAAAGAG GCTTAGGTTA TACTGCTTAG AACCTCCTCT 180 TCAACTAACC TACCGACCCA CCTACCCATA AATCCATACC TACACACACA CCCCTTTCCT 240 TTCCTCTGCC CTGGTTTTGC CTCGCCTGCT TTCAATTGCA CGTGTGTTGA GTATAGCCTT 300 TGCCTCTGCC TACTCAGCTC CTTGAACTGA GGGTGAAATT GAGACCCAGA GGAATGGGAT 360 TTACAGCTTC TTGCTTTCTT CTTGCCTTGT CCTAGAACTG AAGTACAAAT GGGAAGAAGC 420 TTTGATGAAG GAAGACCCCC ATCCAAGAAC ATCTAGTTTT CAGGTGCCAT AACAGCAGAG 480 CAAGTTCA 488 Seq ID NO : 33 DNA Sequence

Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 CTCCCAGAGT GCTAGGATTA CAGGCATGAG CCACTGCTCC CAGCCTTCCA GAGGAATTTT 60 AAGCCCATGT CCAAACATTC TGTTTGTATA AATATATTCT AATTTTTAAA TAAATAGTTT 120 CTACTTTTCT GAACTTTATA TTTTTTCTTG CTATAATGGA TTTTCATAAT CAGAAAAGAT 180 TAAATTAGTA ATCATGAATT GCCTTCAATA TTTGGCAGTA AGTCAATGAA ATAATAAGGC 240 ACTTATATAC CATCTTTGAC ATCATTAAAA GTATCAAATC CCATTAATCT AAAACTTCTT 300 TAAGCATTTT GAAAGCAGAA AATGTTTACA TGGTTCTTTC AGTTCCTCAG GCTTTTTGTC 360 TAATGATGCG TGACTTAGGA TAAGATTTGA ATTAAGTGCC CAGCTTGAAA CATAATAATT 420 TTTCTGTATA AGCCACAGAT CCTCTACCTC CTTTGTGTTA AAGCCTTTAT ATGAAACAAT 480 TAAGTAGAAG CATTCAATAG TGTGTCATTA ACTGTTCATA CTAATAAATG GATACAGCAC 540 ATTTTCATGG CCTGTAATGT AGAACATACT ATATAAAGTT CTCAGTTTGG GGATGACTAG 600 GTTTCTGGAA GGAATAGAAT GCTAAATCAA TGGATGGCAT TGGGCTGAGA AACACTGCTG 660 CTACTAATCA GCCTTGAATG TGTAATGTGA ACATGCAAAA GAGAACATGC ATACACTCAA 720 ATTTGTACAA TGCTATAACT GGAAGTTGAA GGACTTGAAT TTTTATATTG TGCTATTGTT 780 ATGTTTTCTG TAATTGTTTA TATCTAAGGA ATTTTTGAGG TAATATAAAA GAAAAAGAGA 840 ATAATGAACA ATGATGTCAC TGGAGGGTTT TTACATTAAA TTAGATCATT TTTCTTCTTA 900 TTCACAATAA TAATCTTAAT CTTTAAGAAT TAATTATAAT TTAATATTAT AATTCATAAT 960 CTTTAAGAAT TAATAATTAT AATTTAATAT TATAATTAAT AATCTTTAAG AATTAATAAT 1020 ATAATTTAAT ATTATAATTA ATAATCTTTA AGAATTAATA ATTACAATTA ATAATTAATA 1080 ATAATCTTAA TCTTTAAGAA TTAATAATAA TCCTTAATCG CAATAATAAT CGCAAGGAGG 1140 AGAAGTAAGT CCCTCCTCCT TCTGTATGAA CTTTTCTCCC ACATGCTGCT GTATGGTTTA 1200 GTGAGAGTGA AGTTCTAAAG AACATCAATA TGATTGGTGG GATAATCCAA AGACATTTTT 1260 TCAGAATCAA ATGGCATGTC GAAGGTTTGT TTCTTGCATA TGTATTTACT GGTCCACAGC 1320 ACAAAATAAA GTGACCACAT ATACATAGGA AAGTTGAATT TGTACACATA CAGCATCTGA 1380 AATGTATCTG ATGTTCAGCA TCAAGATTTC ACTGAACATT GTAGAAATGT GTATCTTTTG 1440 CATGTATATT TTACATTGAT TTTCTATTTA TGTACATCTA GAAAGTTTTA ACCCTAATAA 1500 ATAGTTTTGT AATTTTGAAT AATAGTGTCA GTTTATATGT GAGGGAGTAG AGACAGAGAG 1560 GTTAGCACTG GATAATAATT AGTAAGGCCA AAGGAGAAAA TTTCATAGAA AATATTGTTG 1620 TTGTCATAAT GAGTACAGCA TGAAAGGCTT CCTCTACAAG ACACTAGTCA AAGAGTTGAG 1680 AGCTGCGGTT TCTAATCTTT GTCCATTACT CCCTTACTCC CTATGAGACT GTGGACCTGT 1740 CACTTGGCCT CTCTGGTCTT CAGTTTTCTC ACCAGTAAAA CAAGGAACTT GAACCAAATG 1800 ACCTCTAGTG TTCCCCTTGG GTTTAAATGT CTATAAATGT TCAATGACTA GAATGTATTG 1860 CGTTTTTCTT TATTCTTTTT GCTTTGAGAA AAGAGAATGT GATTTAAGAG TAATAATTTG 1920 AATACCAATT ATCCACATTA AAATTGTGTC CTCTATGTGT AAGGCATAGC ACATTTAGCA 1980 CACATACATA AGCACACTAA GCACCTTACA AATATCCTCA TTTATTCTTT ACATAATCTT 2040 TTGAAATTGA TTATGTAATA CACACTGTTT TTGAACAATT GGTGACTTCC AGCTGTTTAA 2100 AACAAACTAC AGTATGGTGC TTGAGTACTG ACTTAGGAGG TCAGCATTGG TTTCACTAGG 2160 AGCTTCTCAA AGCACGCTGC CAAACATGCT CCAGTCTCAT TGTCAAGGCC TTAGACCAGG 2220 CAATCATTAC GGCAGTGGTT CTTCAACTTC AGCAGCAGCA AAACGATCTG GCGGGGGCTT 2280 GGTGAAACAG ACTGCTGGGC TCGACCACCA GAATTTCTCA TTCAGAGGGT CTGGCCTGAT 2340 CACTTGCATT TCTAATCACT TCCCAGGTGA TGCAGATGTT TCTGGTCCAG GGACCCCAGT 2400 TTGAGAACCA CTGTATTAAA ATTTCCTTCA TCTCTATAGA AATGGAAAGA TTTTTTATAA 2460 GTCCTCTAAT TTGCTTTAAG ATAAATGAGA TTTCACTTAA TTCTGTTGGA GAAATTGTTT 2520 TAAAAATTGT GCTAAAGAAC CGAAAATCAC TTTATGTTAA GGCTCTATTT ATAGCAAGTG 2580 AACTTTTCAT GAGTTAATAA AGGCCTACAA AAATAATTTT GACTGTGAAA CTAATTAAAA 2640 TCTCTGTGTT TCATTTAAAG CATAAACATA TTTGAATAAA AATAGGTTAA CAATAATTTG 2700 GGACATGTAT TCAGTATAAT TTTAAGATAA TTTTACAAAA TATATGTAAC ATTGCATTTG 2760 TTTCTGTAAA ATATCTTCGG AAAAAGCCTT GTTTTCCCTA GTGTGTTATT TGTTGAATTT 2820 CTTGTTAAAT GTATTTTTTC CCATTGAAAA AAATGTTTTT AATCAATGTG ATCAATACAG 2880 CTATCTATAT GCCCTGCTTT CACTGTA 2907 Seq ID NO : 34 DNA Sequence Nucleic Acid Accession # : NM 003979. 2 Coding sequence : 254.. 1357 1 11 21 31 41 51 ATAACAGCAT GAAGTGCCGT GGAACTGGAA TAGGCGTGTC CTCTCCCTCG ACCCTCCCCC 60 TCCTTGTCCC TCTGCTCACC CCTCGCTCGT TCCCTCCCTC CGGCGAGGGC CGCCTTTATA 120 ACAACTGCTC AGAGTGCGAG GGCGGGATAG CTGTCCAAGG TCTCCCCCAG CACTGAGGAG 180 CTCGCCTGCT GCCCTCTTGC GCGCGGGAAG CAGCACCAAG TTCACGGCCA ACGCCTTGGC 240 ACTAGGGTCC AGAATGGCTA CAACAGTCCC TGATGGTTGC CGCAATGGCC TGAAATCCAA 300 GTACTACAGA CTTTGTGATA AGGCTGAAGC TTGGGGCATC GTCCTAGAAA CGGTGGCCAC 360 AGCCGGGGTT GTGACCTCGG TGGCCTTCAT GCTCACTCTC CCGATCCTCG TCTGCAAGGT 420 GCAGGACTCC AACAGGCGAA AAATGCTGCC TACTCAGTTT CTCTTCCTCC TGGGTGTGTT 480 GGGCATCTTT GGCCTCACCT TCGCCTTCAT CATCGGACTG GACGGGAGCA CAGGGCCCAC 540 ACGCTTCTTC CTCTTTGGGA TCCTCTTTTC CATCTGCTTC TCCTGCCTGC TGGCTCATGC 600 TGTCAGTCTG ACCAAGCTCG TCCGGGGGAG GAAGCCCCTT TCCCTGTTGG TGATTCTGGG 660 TCTGGCCGTG GGCTTCAGCC TAGTCCAGGA TGTTATCGCT ATTGAATATA TTGTCCTGAC 720 CATGAATAGG ACCAACGTCA ATGTCTTTTC TGAGCTTTCC GCTCCTCGTC GCAATGAAGA 780 CTTTGTCCTC CTGCTCACCT ACGTCCTCTT CTTGATGGCG CTGACCTTCC TCATGTCCTC 840 CTTCACCTTC TGTGGTTCCT TCACGGGCTG GAAGAGACAT GGGGCCCACA TCTACCTCAC 900 GATGCTCCTC TCCATTGCCA TCTGGGTGGC CTGGATCACC CTGCTCATGC TTCCTGACTT 960 TGACCGCAGG TGGGATGACA CCATCCTCAG CTCCGCCTTG GCTGCCAATG GCTGGGTGTT 1020 CCTGTTGGCT TATGTTAGTC CCGAGTTTTG GCTGCTCACA AAGCAACGAA ACCCCATGGA 1080 TTATCCTGTT GAGGATGCTT TCTGTAAACC TCAACTCGTG AAGAAGAGCT ATGGTGTGGA 1140 GAACAGAGCC TACTCTCAAG AGGAAATCAC TCAAGGTTTT GAAGAGACAG GGGACACGCT 1200 CTATGCCCCC TATTCCACAC ATTTTCAGCT GCAGAACCAG CCTCCCCAAA AGGAATTCTC 1260 CATCCCACGG GCCCACGCTT GGCCGAGCCC TTACAAAGAC TATGAAGTAA AGAAAGAGGG 1320 CAGCTAACTC TGTCCTGAAG AGTGGGACAA ATGCAGCCGG GCGGCAGATC TAGCGGGAGC 1380 TCAAAGGGAT GTGGGCGAAA TCTTGAGTCT TCTGAGAAAA CTGTACAAGA CACTACGGGA 1440 ACAGTTTGCC TCCCTCCCAG CCTCAACCAC AATTCTTCCA TGCTGGGGCT GATGTGGGCT 1500 AGTAAGACTC CAGTTCTTAG AGGCGCTGTA GTATTTTTTT TTTTTTGTCT CATCCTTTGG 1560

ATACTTCTTT TAAGTGGGAG TCTCAGGCAA CTCAAGTTTA GACCCTTACT CTTTTTGTTT 1620 GTTTTTTGAA ACAGGATCTT GCTCTGTCAC CCAGGCTTGA GTGCAGTGGT GCGATCACAG 1680 CCCAGTGCAG CCTCGACCAC CTGTGCTCAA GCAATCCTCC CATCTCCATC TCCCAAAGTG 1740 CTGGGATGAC AGGCGTGAGC CACAGCTCCC AGCCTAGGCC CTTAATCTTG CTGTTATTTT 1800 CCATGGACTA AAGGTCTGGT CATCTGAGCT CACGCTGGCT CACACAGCTC TAGGGGCCTG 1860 CTCCTCTAAC TCACAGTGGG TTTTGTGAGG CTCTGTGGCC CAGAGCAGAC CTGCATATCT 1920 GAGCAAAAAT AGCAAAAGCC TCTCTCAGCC CACTGGCCTG AATCTACACT GGAAGCCAAC 1980 TTGCTGGCAC CCCCGCTCCC CAACCCTTCT TGCCTGGGTA GGAGAGGCTA AAGATCACCC 2040 TAAATTTACT CATCTCTCTA GTGCTGCCTC ACATTGGGCC TCAGCAGCTC CCCAGCACCA 2100 ATTCACAGGT CACCCCTCTC TTCTTGCACT GTCCCCAAAC TTGCTGTCAA TTCCGAGATC 2160 TAATCTCCCC CTACGCTCTG CCAGGAATTC TTTCAGACCT CACTAGCACA AGCCCGGTTG 2220 CTCCTTGTCA GGAGAATTTG TAGATCATTC TCACTTCAAA TTCCTGGGGC TGATACTTCT 2280 CTCATCTTGC ACCCCAACCT CTGTAAATAG ATTTACCGCA TTTACGGCTG CATTCTGTAA 2340 GTGGGCATGG TCTCCTAATG GAGGAGTGTT CATTGTATAA TAAGTTATTC ACCTGAGTAT 2400 GCAATAAAGA TGTGGTGGCC ACTCTTTCAT GGTGGTGGCA GCAAAAAAAA AAAAAA 2456 Seq ID NO : 35 DNA Sequence Nucleic Acid Accession # : Nom 032957. 1 Coding sequence : 1.. 4203 1 11 21 31 41 51 ATGCCCAAGA TAGTCCTGAA TGGTGTGACC GTAGACTTCC CTTTCCAGCC CTACAAATGC 60 CAACAGGAGT ACATGACCAA GGTCCTGGAA TGTCTGCAGC AGAAGGTGAA TGGCATCCTG 120 GAGAGCCCTA CGGGTACAGG GAAGACGCTG TGCCTGCTGT GCACCACGCT GGCCTGGCGA 180 GAACACCTCC GAGACGGCAT CTCTGCCCGC AAGATTGCCG AGAGGGCGCA AGGAGAGCTT 240 TTCCCGGATC GGGCCTTGTC ATCCTGGGGC AACGCTGCTG CTGCTGCTGG AGACCCCATA 300 GCTTGCTACA CGGACATCCC AAAGATTATT TACGCCTCCA GGACCCACTC GCAACTCACA 360 CAGGTCATCA ACGAGCTTCG GAACACCTCC TACCGGCCTA AGGTGTGTGT GCTGGGCTCC 420 CGGGAGCAGC TGTGCATCCA TCCTGAGGTG AAGAAACAAG AGAGTAACCA TCTACAGATC 480 CACTTGTGCC GTAAGAAGGT GGCAAGTCGC TCCTGTCATT TCTACAACAA CGTAGAAGAA 540 AAAAGCCTGG AGCAGGAGCT GGCCAGCCCC ATCCTGGACA TTGAGGACTT GGTCAAGAGC 600 GGAAGCAAGC ACAGGGTGTG CCCTTACTAC CTGTCCCGGA ACCTGAAGCA GCAAGCCGAC 660 ATCATATTCA TGCCGTACAA TTACTTGTTG GATGCCAAGA GCCGCAGAGC ACACAACATT 720 GACCTGAAGG GGACAGTCGT GATCTTTGAC GAAGCTCACA ACGTGGAGAA GATGTGTGAA 780 GAATCGGCAT CCTTTGACCT GACTCCCCAT GACCTGGCTT CAGGACTGGA CGTCATAGAC 840 CAGGTGCTGG AGGAGCAGAC CAAGGCAGCG CAGCAGGGTG AGCCCCACCC GGAGTTCAGC 900 GCGGACTCCC CCAGCCCAGG GCTGAACATG GAGCTGGAAG ACATTGCAAA GCTGAAGATG 960 ATCCTGCTGC GCCTGGAGGG GGCCATCGAT GCTGTTGAGC TGCCTGGAGA CGACAGCGGT 1020 GTCACCAAGC CAGGGAGCTA CATCTTTGAG CTGTTTGCTG AAGCCCAGAT CACGTTTCAG 1080 ACCAAGGGCT GCATCCTGGA CTCGCTGGAC CAGATCATCC AGCACCTGGC AGGACGTGCT 1140 GGAGTGTTCA CCAACACGGC CGGACTGCAG AAGCTGGCGG ACATTATCCA GATTGTGTTC 1200 AGTGTGGACC CCTCCGAGGG CAGCCCTGGT TCCCCAGCAG GGCTGGGGGC CTTACAGTCC 1260 TATAAGGTGC ACATCCATCC TGATGCTGGT CACCGGAGGA CGGCTCAGCG GTCTGATGCC 1320 TGGAGCACCA CTGCAGCCAG AAAGCGAGGG AAGGTGCTGA GCTACTGGTG CTTCAGTCCC 1380 GGCCACAGCA TGCACGAGCT GGTCCGCCAG GGCGTCCGCT CCCTCATCCT TACCAGCGGC 1440 ACGCTGGCCC CGGTGTCCTC CTTTGCTCTG GAGATGCAGA TCCCTTTCCC AGTCTGCCTG 1500 GAGAACCCAC ACATCATCGA CAAGCACCAG ATCTGGGTGG GGGTCGTCCC CAGAGGCCCC 1560 GATGGAGCCC AGTTGAGCTC CGCGTTTGAC AGACGGTTTT CCGAGGAGTG CTTATCCTCC 1620 CTGGGGAAGG CTCTGGGCAA CATCGCCCGC GTGGTGCCCT ATGGGCTCCT GATCTTCTTC 1680 CCTTCCTATC CTGTCATGGA GAAGAGCCTG GAGTTCTGGC GGGCCCGCGA CTTGGCCAGG 1740 AAGATGGAGG CGCTGAAGCC GCTGTTTGTG GAGCCCAGGA GCAAAGGCAG CTTCTCCGAG 1800 ACCATCAGTG CTTACTATGC AAGGGTTGCC GCCCCTGGGT CCACCGGCGC CACCTTCCTG 1860 GCGGTCTGCC GGGGCAAGGC CAGCGAGGGG CTGGACTTCT CAGACACGAA TGGCCGTGGT 1920 GTGATTGTCA CGGGCCTCCC GTACCCCCCA CGCATGGACC CCCGGGTTGT CCTCAAGATG 1980 CAGTTCCTGG ATGAGATGAA GGGCCAGGGT GGGGCTGGGG GCCAGTTCCT CTCTGGGCAG 2040 GAGTGGTACC GGCAGCAGGC GTCCAGGGCT GTGAACCAGG CCATCGGGCG AGTGATCCGG 2100 CACCGCCAGG ACTACGGAGC TGTCTTCCTC TGTGACCACA GGTTCGCCTT TGCCGACGCA 2160 AGAGCCCAAC TGCCCTCCTG GGTGCGTCCC CACGTCAGGG TGTATGACAA CTTTGGCCAT 2220 GTCATCCGAG ACGTGGCCCA GTTCTTCCGT GTTGCCGAGC GAACTATGCC AGCGCCGGCC 2280 CCCCGGGCTA CAGCACCCAG TGTGCGTGGA GAAGATGCTG TCAGCGAGGC CAAGTCGCCT 2340 GGCCCCTTCT TCTCCACCAG GAAAGCTAAG AGTCTGGACC TGCATGTCCC CAGCCTGAAG 2400 CAGAGGTCCT CAGGGTCACC AGCTGCCGGG GACCCCGAGA GTAGCCTGTG TGTGGAGTAT 2460 GAGCAGGAGC CAGTTCCTGC CCGGCAGAGG CCCAGGGGGC TGCTGGCCGC CCTGGAGCAC 2520 AGCGAACAGC GGGCGGGGAG CCCTGGCGAG GAGCAGGCCC ACAGCTGCTC CACCCTGTCC 2580 CTCCTGTCTG AGAAGAGGCC GGCAGAAGAA CCGCGAGGAG GGAGGAAGAA GATCCGGCTG 2640 GTCAGCCACC CGGAGGAGCC CGTGGCTGGT GCACAGACGG ACAGGGCCAA GCTCTTCATG 2700 GTGGCCGTGA AGCAGGAGTT GAGCCAAGCC AACTTTGCCA CCTTCACCCA GGCCCTGCAG 2760 GACTACAAGG GTTCCGATGA CTTCGCCGCC CTGGCCGCCT GTCTCGGCCC CCTCTTTGCT 2820 GAGGACCCCA AGAAGCACAA CCTGCTCCAA GGCTTCTACC AGTTTGTGCG GCCCCACCAT 2880 AAGCAGCAGT TTGAGGAGGT CTGTATCCAG CTGACAGGAC GAGGCTGTGG CTATCGGCCT 2940 GAGCACAGCA TTCCCCGAAG GCAGCGGGCA CAGCCGGTCC TGGACCCCAC TGGAAGAACG 3000 GCGCCGGATC CCAAGCTGAC CGTGTCCACG GCTGCAGCCC AGCAGCTGGA CCCCCAAGAG 3060 CACCTGAACC AGGGCAGGCC CCACCTGTCG CCCAGGCCAC CCCCAACAGG AGACCCTGGC 3120 AGCCAACCAC AGTGGGGGTC TGGAGTGCCC AGAGCAGGGA AGCAGGGCCA GCACGCCGTG 3180 AGCGCCTACC TGGCTGATGC CCGCAGGGCC CTGGGGTCCG CGGGCTGTAG CCAACTCTTG 3240 GCAGCGCTGA CAGCCTATAA GCAAGACGAC GACCTCGACA AGGTGCTGGC TGTGTTGGCC 3300 GCCCTGACCA CTGCAAAGCC AGAGGACTTC CCCCTGCTGC ACAGGTTCAG CATGTTTGTG 3360 CGTCCACACC ACAAGCAGCG CTTCTCACAG ACGTGCACAG ACCTGACCGG CCGGCCCTAC 3420 CCGGGCATGG AGCCACCGGG ACCCCAGGAG GAGAGGCTTG CCGTGCCTCC TGTGCTTACC 3480 CACAGGGCTC CCCAACCAGG CCCCTCACGG TCCGAGAAGA CCGGGAAGAC CCAGAGCAAG 3540 ATCTCGTCCT TCCTTAGACA GAGGCCAGCA GGGACTGTGG GGGCGGGCGG TGAGGATGCA 3600 GGTCCCAGCC AGTCCTCAGG ACCTCCCCAC GGGCCTGCAG CATCTGAGTG GGGTGAGCCT 3660 CATGGGAGAG ACATCGCTGG GCAGCAGGCC ACGGGAGCTC CGGGCGGGCC CCTCTCAGCA 3720 GGCTGTGTGT GCCAGGGCTG TGGGGCAGAG GACGTGGTGC CCTTCCAGTG CCCTGCCTGT 3780

GACTTCCAGC GCTGCCAAGC CTGCTGGCAA CGGCACCTTC AGGCCTCTAG GATGTGCCCA 3840 GCCTGCCACA CCGCCTCCAG GAAGCAGAGC GTCATGCAGG TCTTCTGGCC AGAGCCCCAC 3900 AAGGACCATG AGGGCGCTGG AGGGGCCAGG CCTGTCGCTG CTGTGCCTGG TGTTGGCGCT 3960 GCCTGCCCTG CTGCCGGTGC CGGCTGTACG CGGAGTGGCA GAAACACCCA CCTACCCCTG 4020 GCGGGACGCA GAGACAGGGG AGCGGCTGGT GTGTGCCCAG TGCCCCCCAG GCACCTTTGT 4080 GCAGCGGCCG TGCCGCCGAG ACAGCCCCAC GACGTGTGGC CCGTGTCCAC CGCGCCACTA 4140 CACGCAGTTC TGGAACTACC TGGAGCGCTG CCGCTACTGC AACGTCCTCT GCGGGGAGCG 4200 TGAGGAGGAG GCACGGGCTT GCCACGCCAC CCACAACCGT GCCTGCCGCT GCCGCACCGG 4260 CTTCTTCGCG CACGCTGGTT TCTGCTTGGA GCACGCATCG TGTCCACCTG GTGCCGGCGT 4320 GATTGCCCCG GGCACCCCCA GCCAGAACAC GCAGTGCCAG CCGTGCCCCC CAGGCACCTT 4380 CTCAGCCAGC AGCTCCAGCT CAGAGCAGTG CCAGCCCCAC CGCAACTGCA CGGCCCTGGG 4440 CCTGGCCCTC AATGTGCCAG GCTCTTCCTC CCATGACACC CTGTGCACCA GCTGCACTGG 4500 CTTCCCCCTC AGCACCAGGG TACCAGGAGC TGAGGAGTGT GAGCGTGCCG TCATCGACTT 4560 TGTGGCTTTC CAGGACATCT CCATCAAGAG GCTGCAGCGG CTGCTGCAGG CCCTCGAGGC 4620 CCCGGAGGGC TGGGGTCCGA CACCAAGGGC GGGCCGCGCG GCCTTGCAGC TGAAGCTGCG 4680 TCGGCGGCTC ACGGAGCTCC TGGGGGCGCA GGACGGGGCG CTGCTGGTGC GGCTGCTGCA 4740 GGCGCTGCGC GTGGCCAGGA TGCCCGGGCT GGAGCGGAGC GTCCGTGAGC GCTTCCTCCC 4800 TGTGCACTGA TCCTGGCCCC CTCTTATTTA TTCTACATCC TTGGCACCCC ACTTGCACTG 4860 AAAGAGGCTT TTTTTTAAAT AGAAGAAATG AGGTTTCTTA AAGCTTATTT TTATAAAGCT 4920 TTTTCATAAA ACTGGTTGTA GTTGC 4945 Seq ID NO : 36 DNA Sequence Nucleic Acid Accession # : NM 016434. 1 Coding sequence : 828.. 4487 1 11 21 31 41 51 AGTCAGCCCT GCTGCCAGCC AGTGCCGGGT GCTGGGGACT CAGGGAGGCC CGCCGGGACC 60 ACTGCGGGAC AGTGAGCCGA GCAGAAGCTG GAACGCAGGA GAGGAAGGAG AGGGGGCGGT 120 CAGGGCTCTC AGGAGCCGGG TCCTGGGCAA GGCGCAGCCG TTTTCAAATT TTCAGGAAAG 180 CGGTCGGCTC ACACTCGAGC AGTAAAAAGA TGCCTCTGGG GAGGAGGCCC GTGCAGCTCT 240 CCGGGCAATG GTGGTGGCTC GGCCTAGAGA GGCGGTAGTG GAACGCAGAC CCTGGTGGGG 300 GAATGACATC AAGGGAGGAG ACGGGCGGGA CCCCAGATTT CTGCCTGTGG GCGATGGAAG 360 TGAGGTTCAC TGGCCAGCGG AGCCGGACAC AGAACGCGCA AAACGCCGTG TAGGCCTGGA 420 GGAGCCGAAG AGCAGGCGGA CCCCCTCCGC GGGGGAACAG TTTCCGCCGG GAGCACAAAG 480 CAACGGACCG GAAGTGGGGG GCGGAAGTGC AGTGGGCTCA GCGCCGACTG CGCGCCTCTG 540 CCCGCGAAAA CTCTGAGCTG GCTGACAGCT GGGGACGGGT GGCGGCCCTC GACTGGAGTC 600 GGTTGAGTTC CTGAGGGACC CCGGTTCTGG AAGGTTCGCC GCGGAGACAA GTGAGCAGTC 660 TGTGCCATAG GGATTCTCGA AGAGAACAGC GTTGTGTCCC AGTGCACATG CTCGCATCGC 720 TTACCAGGAG TGCCCGAGAC CCTAAGATGT TCGGAGTGGT TTTTTCGCAC AGACCCGAAT 780 AGCCTGCCCC TCAGCCACGC TCTGTGCCCT TCTGAGAACA GGCTGATATG CCCAAGATAG 840 TCCTGAATGG TGTGACCGTA GACTTCCCTT TCCAGCCCTA CAAATGCCAA CAGGAGTACA 900 TGACCAAGGT CCTGGAATGT CTGCAGCAGA AGGTGAATGG CATCCTGGAG AGCCCTACGG 960 GTACAGGGAA GACGCTGTGC CTGCTGTGCA CCACGCTGGC CTGGCGAGAA CACCTCCGAG 1020 ACGGCATCTC TGCCCGCAAG ATTGCCGAGA GGGCGCAAGG AGAGCTTTTC CCGGATCGGG 1080 CCTTGTCATC CTGGGGCAAC GCTGCTGCTG CTGCTGGAGA CCCCATAGCT TGCTACACGG 1140 ACATCCCAAA GATTATTTAC GCCTCCAGGA CCCACTCGCA ACTCACACAG GTCATCAACG 1200 AGCTTCGGAA CACCTCCTAC CGGCCTAAGG TGTGTGTGCT GGGCTCCCGG GAGCAGCTGT 1260 GCATCCATCC TGAGGTGAAG AAACAAGAGA GTAACCATCT ACAGATCCAC TTGTGCCGTA 1320 AGAAGGTGGC AAGTCGCTCC TGTCATTTCT ACAACAACGT AGAAGAAAAA AGCCTGGAGC 1380 AGGAGCTGGC CAGCCCCATC CTGGACATTG AGGACTTGGT CAAGAGCGGA AGCAAGCACA 1440 GGGTGTGCCC TTACTACCTG TCCCGGAACC TGAAGCAGCA AGCCGACATC ATATTCATGC 1500 CGTACAATTA CTTGTTGGAT GCCAAGAGCC GCAGAGCACA CAACATTGAC CTGAAGGGGA 1560 CAGTCGTGAT CTTTGACGAA GCTCACAACG TGGAGAAGAT GTGTGAAGAA TCGGCATCCT 1620 TTGACCTGAC TCCCCATGAC CTGGCTTCAG GACTGGACGT CATAGACCAG GTGCTGGAGG 1680 AGCAGACCAA GGCAGCGCAG CAGGGTGAGC CCCACCCGGA GTTCAGCGCG GACTCCCCCA 1740 GCCCAGGGCT GAACATGGAG CTGGAAGACA TTGCAAAGCT GAAGATGATC CTGCTGCGCC 1800 TGGAGGGGGC CATCGATGCT GTTGAGCTGC CTGGAGACGA CAGCGGTGTC ACCAAGCCAG 1860 GGAGCTACAT CTTTGAGCTG TTTGCTGAAG CCCAGATCAC GTTTCAGACC AAGGGCTGCA 1920 TCCTGGACTC GCTGGACCAG ATCATCCAGC ACCTGGCAGG ACGTGCTGGA GTGTTCACCA 1980 ACACGGCCGG ACTGCAGAAG CTGGCGGACA TTATCCAGAT TGTGTTCAGT GTGGACCCCT 2040 CCGAGGGCAG CCCTGGTTCC CCAGCAGGGC TGGGGGCCTT ACAGTCCTAT AAGGTGCACA 2100 TCCATCCTGA TGCTGGTCAC CGGAGGACGG CTCAGCGGTC TGATGCCTGG AGCACCACTG 2160 CAGCCAGAAA GCGAGGGAAG GTGCTGAGCT ACTGGTGCTT CAGTCCCGGC CACAGCATGC 2220 ACGAGCTGGT CCGCCAGGGC GTCCGCTCCC TCATCCTTAC CAGCGGCACG CTGGCCCCGG 2280 TGTCCTCCTT TGCTCTGGAG ATGCAGATCC CTTTCCCAGT CTGCCTGGAG AACCCACACA 2340 TCATCGACAA GCACCAGATC TGGGTGGGGG TCGTCCCCAG AGGCCCCGAT GGAGCCCAGT 2400 TGAGCTCCGC GTTTGACAGA CGGTTTTCCG AGGAGTGCTT ATCCTCCCTG GGGAAGGCTC 2460 TGGGCAACAT CGCCCGCGTG GTGCCCTATG GGCTCCTGAT CTTCTTCCCT TCCTATCCTG 2520 TCATGGAGAA GAGCCTGGAG TTCTGGCGGG CCCGCGACTT GGCCAGGAAG ATGGAGGCGC 2580 TGAAGCCGCT GTTTGTGGAG CCCAGGAGCA AAGGCAGCTT CTCCGAGACC ATCAGTGCTT 2640 ACTATGCAAG GGTTGCCGCC CCTGGGTCCA CCGGCGCCAC CTTCCTGGCG GTCTGCCGGG 2700 GCAAGGCCAG CGAGGGGCTG GACTTCTCAG ACACGAATGG CCGTGGTGTG ATTGTCACGG 2760 GCCTCCCGTA CCCCCCACGC ATGGACCCCC GGGTTGTCCT CAAGATGCAG TTCCTGGATG 2820 AGATGAAGGG CCAGGGTGGG GCTGGGGGCC AGTTCCTCTC TGGGCAGGAG TGGTACCGGC 2880 AGCAGGCGTC CAGGGCTGTG AACCAGGCCA TCGGGCGAGT GATCCGGCAC CGCCAGGACT 2940 ACGGAGCTGT CTTCCTCTGT GACCACAGGT TCGCCTTTGC CGACGCAAGA GCCCAACTGC 3000 CCTCCTGGGT GCGTCCCCAC GTCAGGGTGT ATGACAACTT TGGCCATGTC ATCCGAGACG 3060 TGGCCCAGTT CTTCCGTGTT GCCGAGCGAA CTATGCCAGC GCCGGCCCCC CGGGCTACAG 3120 CACCCAGTGT GCGTGGAGAA GATGCTGTCA GCGAGGCCAA GTCGCCTGGC CCCTTCTTCT 3180 CCACCAGGAA AGCTAAGAGT CTGGACCTGC ATGTCCCCAG CCTGAAGCAG AGGTCCTCAG 3240 GGTCACCAGC TGCCGGGGAC CCCGAGAGTA GCCTGTGTGT GGAGTATGAG CAGGAGCCAG 3300 TTCCTGCCCG GCAGAGGCCC AGGGGGCTGC TGGCCGCCCT GGAGCACAGC GAACAGCGGG 3360 CGGGGAGCCC TGGCGAGGAG CAGGCCCACA GCTGCTCCAC CCTGTCCCTC CTGTCTGAGA 3420 AGAGGCCGGC AGAAGAACCG CGAGGAGGGA GGAAGAAGAT CCGGCTGGTC AGCCACCCGG 3480

AGGAGCCCGT GGCTGGTGCA CAGACGGACA GGGCCAAGCT CTTCATGGTG GCCGTGAAGC 3540 AGGAGTTGAG CCAAGCCAAC TTTGCCACCT TCACCCAGGC CCTGCAGGAC TACAAGGGTT 3600 CCGATGACTT CGCCGCCCTG GCCGCCTGTC TCGGCCCCCT CTTTGCTGAG GACCCCAAGA 3660 AGCACAACCT GCTCCAAGGC TTCTACCAGT TTGTGCGGCC CCACCATAAG CAGCAGTTTG 3720 AGGAGGTCTG TATCCAGCTG ACAGGACGAG GCTGTGGCTA TCGGCCTGAG CACAGCATTC 3780 CCCGAAGGCA GCGGGCACAG CCGGTCCTGG ACCCCACTGG AAGAACGGCG CCGGATCCCA 3840 AGCTGACCGT GTCCACGGCT GCAGCCCAGC AGCTGGACCC CCAAGAGCAC CTGAACCAGG 3900 GCAGGCCCCA CCTGTCGCCC AGGCCACCCC CAACAGGAGA CCCTGGCAGC CAACCACAGT 3960 GGGGGTCTGG AGTGCCCAGA GCAGGGAAGC AGGGCCAGCA CGCCGTGAGC GCCTACCTGG 4020 CTGATGCCCG CAGGGCCCTG GGGTCCGCGG GCTGTAGCCA ACTCTTGGCA GCGCTGACAG 4080 CCTATAAGCA AGACGACGAC CTCGACAAGG TGCTGGCTGT GTTGGCCGCC CTGACCACTG 4140 CAAAGCCAGA GGACTTCCCC CTGCTGCACA GGTTCAGCAT GTTTGTGCGT CCACACCACA 4200 AGCAGCGCTT CTCACAGACG TGCACAGACC TGACCGGCCG GCCCTACCCG GGCATGGAGC 4260 CACCGGGACC CCAGGAGGAG AGGCTTGCCG TGCCTCCTGT GCTTACCCAC AGGGCTCCCC 4320 AACCAGGCCC CTCACGGTCC GAGAAGACCG GGAAGACCCA GAGCAAGATC TCGTCCTTCC 4380 TTAGACAGAG GCCAGCAGGG ACTGTGGGGG CGGGCGGTGA GGATGCAGGT CCCAGCCAGT 4440 CCTCAGGACC TCCCCACGGG CCTGCAGCAT CTGAGTGGGG CCTCTAGGAT GTGCCCAGCC 4500 TGCCACACCG CCTCCAGGAA GCAGAGCGTC ATGCAGGTCT TCTGGCCAGA GCCCCAGTGA 4560 GTGCCCACGG AGGCCCCCAG CACACCCAAC GTGGCTTGAT CACCTGCCTG TCCAGCTCTG 4620 GTGGGCCAAG AACCCACCCA ACAGAATAGG CCAGCCCATG CCAGCCGGCT TGGCCCGCTG 4680 CAGGCCTCAG GCAGGCGGGG CCCATGGTTG GTCCCTGCGG TGGGACCGGA TCTGGGCCTG 4740 CCTCTGAGAA GCCCTGAGCT ACCTTGGGGT CTGGGGTGGG TTTCTGGGAA AGTGCTTCCC 4800 CAGAACTTCC CTGGCTCCTG GCCTGTGAGT GGTGCCACAG GGGCACCCCA GCTGAGCCCC 4860 TCACCGGGAA GGAGGAGACC CCCGTGGGCA CGTGTCCACT TTTAATCAGG GGACAGGGCT 4920 CTCTAATAAA GCTGCTGGCA GTGCCC 4946 Seq ID NO : 37 DNA Sequence Nucleic Acid Accession # : NM 015647. 2 Coding sequence : 246.. 1883 1 11 21 31 41 51 AGCCTCTCCG GCTACTCGGG GTCAGCGTGG GGCCCCTGCA GCAGATGAGG GTCTTCACTT 60 CGGTGAACTG AACCCTTGAA GCGGCTGTGG GCAGGGCAGC AGGGCTATGG CCACCCCCCA 120 GGTTCGCCTT TGCCGACGCA AGAGCCCAAC TGCCCTCCTG GGTGCGTCCC CACGTCAGGG 180 TGTATGACAA CTTTGGCCAT GTCATCCGAG ACGTGGCCCA GTTCTTCCGT GTTGCCGAGC 240 GAACTATGCC AGCGCCGGCC CCCCGGGCTA CAGCACCCAG TGTGCGTGGA GAAGATGCTG 300 TCAGCGAGGC CAAGTCGCCT GGCCCCTTCT TCTCCACCAG GAAAGCTAAG AGTCTGGACC 360 TGCATGTCCC CAGCCTGAAG CAGAGGTCCT CAGGGTCACC AGCTGCCGGG GACCCCGAGA 420 GTAGCCTGTG TGTGGAGTAT GAGCAGGAGC CAGTTCCTGC CCGGCAGAGG CCCAGGGGGC 480 TGCTGGCCGC CCTGGAGCAC AGCGAACAGC GGGCGGGGAG CCCTGGCGAG GAGCAGGCCC 540 ACAGCTGCTC CACCCTGTCC CTCCTGTCTG AGAAGAGGCC GGCAGAAGAA CCGCGAGGAG 600 GGAGGAAGAA GATCCGGCTG GTCAGCCACC CGGAGGAGCC CGTGGCTGGT GCACAGACGG 660 ACAGGGCCAA GCTCTTCATG GTGGCCGTGA AGCAGGAGTT GAGCCAAGCC AACTTTGCCA 720 CCTTCACCCA GGCCCTGCAG GACTACAAGG GTTCCGATGA CTTCGCCGCC CTGGCCGCCT 780 GTCTCGGCCC CCTCTTTGCT GAGGACCCCA AGAAGCACAA CCTGCTCCAA GGCTTCTACC 840 AGTTTGTGCG GCCCCACCAT AAGCAGCAGT TTGAGGAGGT CTGTATCCAG CTGACGGGAC 900 GAGGCTGTGG CTATCGGCCT GAGCACAGCA TTCCCCGAAG GCAGCGGGCA CAGCCGGTCC 960 TGGACCCCAC TGGAAGAACG GCGCCGGATC CCAAGCTGAC CGTGTCCACG GCTGCAGCCC 1020 AGCAGCTGGA CCCCCAAGAG CACCTGAACC AGGGCAGGCC CCACCTGTCG CCCAGGCCAC 1080 CCCCAACAGG AGACCCTGGC AGCCAACCAC AGTGGGGGTC TGGAGTGCCC AGAGCAGGGA 1140 AGCAGGGCCA GCACGCCGTG AGCGCCTACC TGGCTGATGC CCGCAGGGCC CTGGGGTCCG 1200 CGGGCTGTAG CCAACTCTTG GCAGCGCTGA CAGCCTATAA GCAAGACGAC GACCTCGACA 1260 AGGTGCTGGC TGTGTTGGCC GCCCTGACCA CTGCAAAGCC AGAGGACTTC CCCCTGCTGC 1320 ACAGGTTCAG CATGTTTGTG CGTCCACACC ACAAGCAGCG CTTCTCACAG ACGTGCACAG 1380 ACCTGACCGG CCGGCCCTAC CCGGGCATGG AGCCACCGGG ACCCCAGGAG GAGAGGCTTG 1440 CCGTGCCTCC TGTGCTTACC CACAGGGCTC CCCAACCAGG CCCCTCACGG TCCGAGAAGA 1500 CCGGGAAGAC CCAGAGCAAG ATCTCGTCCT TCCTTAGACA GAGGCCAGCA GGGACTGTGG 1560 GGGCGGGCGG TGAGGATGCA GGTCCCAGCC AGTCCTCAGG ACCTCCCCAC GGGCCTGCAG 1620 CATCTGAGTG GGGTGAGCCT CATGGGAGAG ACATCGCTGG GCAGCAGGCC ACGGGAGCTC 1680 CGGGCGGGCC CCTCTCAGCA GGCTGTGTGT GCCAGGGCTG TGGGGCAGAG GACGTGGTGC 1740 CCTTCCAGTG CCCTGCCTGT GACTTCCAGC GCTGCCAAGC CTGCTGGCAA CGGCACCTTC 1800 AGGCCTCTAG GATGTGCCCA GCCTGCCACA CCGCCTCCAG GAAGCAGAGC GTCATGCAGG 1860 TCTTCTGGCC AGAGCCCCAG TGAGTGCCCA CGGAGGCCCC CAGCACACCC AACGTGGCTT 1920 GATCACCTGC CTGTCCAGCT CTGGTGGGCC AAGAACCCAC CCAACAGAAT AGGCCAGCCC 1980 ATGCCAGCCG GCTTGGCCCG CTGCAGGCCT CAGGCAGGCG GGGCCCATGG TTGGTCCCTG 2040 CGGTGGGACC GGATCTGGGC CTGCCTCTGA GAAGCCCTGA GCTACCTTGG GGTCTGGGGT 2100 GGGTTTCTGG GAAAGTGCTT CCCCAGAACT TCCCTGGCTC CTGGCCTGTG AGTGGTGCCA 2160 CAGGGGCACC CCAGCTGAGC CCCTCACCGG GAAGGAGGAG ACCCCCGTGG GCACGTGTCC 2220 ACTTTTAATC AGGGGACAGG GCTCTCTAAT AAAGCTGCTG GCAGTGCCCA GGAAAAAAAA 2280 AAAAAAAA 2288 Seq ID NO : 38 DNA Sequence Nucleic Acid Accession # : NM 003823. 2 Coding sequence : 101.. 1003 1 11 21 31 41 51 TCCGCAGGCG GACCGGGGGC AAAGGAGGTG GCATGTCGGT CAGGCACAGC AGGGTCCTGT 60 GTCCGCGCTG AGCCGCGCTC TCCCTGCTCC AGCAAGGACC ATGAGGGCGC TGGAGGGGCC 120 AGGCCTGTCG CTGCTGTGCC TGGTGTTGGC GCTGCCTGCC CTGCTGCCGG TGCCGGCTGT 180 ACGCGGAGTG GCAGAAACAC CCACCTACCC CTGGCGGGAC GCAGAGACAG GGGAGCGGCT 240 GGTGTGCGCC CAGTGCCCCC CAGGCACCTT TGTGCAGCGG CCGTGCCGCC GAGACAGCCC 300 CACGACGTGT GGCCCGTGTC CACCGCGCCA CTACACGCAG TTCTGGAACT ACCTGGAGCG 360 CTGCCGCTAC TGCAACGTCC TCTGCGGGGA GCGTGAGGAG GAGGCACGGG CTTGCCACGC 420 CACCCACAAC CGTGCCTGCC GCTGCCGCAC CGGCTTCTTC GCGCACGCTG GTTTCTGCTT 480

GGAGCACGCA TCGTGTCCAC CTGGTGCCGG CGTGATTGCC CCGGGCACCC CCAGCCAGAA 540 CACGCAGTGC CAGCCGTGCC CCCCAGGCAC CTTCTCAGCC AGCAGCTCCA GCTCAGAGCA 600 GTGCCAGCCC CACCGCAACT GCACGGCCCT GGGCCTGGCC CTCAATGTGC CAGGCTCTTC 660 CTCCCATGAC ACCCTGTGCA CCAGCTGCAC TGGCTTCCCC CTCAGCACCA GGGTACCAGG 720 AGCTGAGGAG TGTGAGCGTG CCGTCATCGA CTTTGTGGCT TTCCAGGACA TCTCCATCAA 780 GAGGCTGCAG CGGCTGCTGC AGGCCCTCGA GGCCCCGGAG GGCTGGGGTC CGACACCAAG 840 GGCGGGCCGC GCGGCCTTGC AGCTGAAGCT GCGTCGGCGG CTCACGGAGC TCCTGGGGGC 900 GCAGGACGGG GCGCTGCTGG TGCGGCTGCT GCAGGCGCTG CGCGTGGCCA GGATGCCCGG 960 GCTGGAGCGG AGCGTCCGTG AGCGCTTCCT CCCTGTGCAC TGATCCTGGC CCCCTCTTAT 1020 TTATTCTACA TCCTTGGCAC CCCACTTGCA CTGAAAGAGG CTTTTTTTTA AATAGAAGAA 1080 ATGAGGTTTC TTAAAGCTTA TTTTTATAAA GCTTTTTCAT AAAA 1124 Seq ID NO : 39 DNA Sequence Nucleic Acid Accession # : Nom 032945. 1 Coding sequence : 435.. 1337 1 11 21 31 41 51 CTGACCACTG CAAAGCCAGA GGACTTCCCC CTGCTGCACA GGTTCAGCAT GTTTGTGCGT 60 CCACACCACA AGCAGCGCTT CTCACAGACG TGCACAGACC TGACCGGCCG GCCCTACCCG 120 GGCATGGAGC CACCGGGACC CCAGGAGGAG AGGCTTGCCG TGCCTCCTGT GCTTACCCAC 180 AGGGCTCCCC AACCAGGCCC CTCACGGTCC GAGAAGACCG GGAAGACCCA GAGCAAGATC 240 TCGTCCTTCC TTAGACAGAG GCCAGCAGGG ACTGTGGGGG CGGGCGGTGA GGATGCAGGT 300 CCCAGCCAGT CCTCAGGACC TCCCCACGGG CCTGCAGCAT CTGAGTGGGG CCTCTAGGAT 360 GTGCCCAGCC TGCCACACCG CCTCCAGGAA GCAGAGCGTC ATGCAGGTCT TCTGGCCGGA 420 GCCCCACAAG GACCATGAGG. GCGCTGGAGG GGCCAGGCCT GTCGCTGCTG TGCCTGGTGT 480 TGGCGCTGCC TGCCCTGCTG CCGGTGCCGG CTGTACGCGG AGTGGCAGAA ACACCCACCT 540 ACCCCTGGCG GGACGCAGAG ACAGGGGAGC GGCTGGTGTG CGCCCAGTGC CCCCCAGGCA 600 CCTTTGTGCA GCGGCCGTGC CGCCGAGACA GCCCCACGAC GTGTGGCCCG TGTCCACCGC 660 GCCACTACAC GCAGTTCTGG AACTACCTGG AGCGCTGCCG CTACTGCAAC GTCCTCTGCG 720 GGGAGCGTGA GGAGGAGGCA CGGGCTTGCC ACGCCACCCA CAACCGTGCC TGCCGCTGCC 780 GCACCGGCTT CTTCGCGCAC GCTGGTTTCT GCTTGGAGCA CGCATCGTGT CCACCTGGTG 840 CCGGCGTGAT TGCCCCGGGC ACCCCCAGCC AGAACACGCA GTGCCAGCCG TGCCCCCCAG 900 GCACCTTCTC AGCCAGCAGC TCCAGCTCAG AGCAGTGCCA GCCCCACCGC AACTGCACGG 960 CCCTGGGCCT GGCCCTCAAT GTGCCAGGCT CTTCCTCCCA TGACACCCTG TGCACCAGCT 1020 GCACTGGCTT CCCCCTCAGC ACCAGGGTAC CAGGAGCTGA GGAGTGTGAG CGTGCCGTCA 1080 TCGACTTTGT GGCTTTCCAG GACATCTCCA TCAAGAGGCT GCAGCGGCTG CTGCAGGCCC 1140 TCGAGGCCCC GGAGGGCTGG GGTCCGACAC CAAGGGCGGG CCGCGCGGCC TTGCAGCTGA 1200 AGCTGCGTCG GCGGCTCACG GAGCTCCTGG GGGCGCAGGA CGGGGCGCTG CTGGTGCGGC 1260 TGCTGCAGGC GCTGCGCGTG GCCAGGATGC CCGGGCTGGA GCGGAGCGTC CGTGAGCGCT 1320 TCCTCCCTGT GCACTGATCC TGGCCCCCTC TTATTTATTC TACATCCTTG GCACCCCACT 1380 TGCACTGAAA GAGGCTTTTT TTTAAATAGA AGAAATGAGG TTTCTTAAAA GCTTATTTTT 1440 ATAAAGCTTT TTCATAAAA 1459 Seq ID NO : 40 DNA Sequence Nucleic Acid Accession # : NM000593 Coding sequence : 165.. 2591 1 11 21 31 41 51 GGCACGAGGG TGTGCGTGAT GGAGAAAATT GGGCACCAGG GCTGCTCCCG AGATTCTCAG 60 ATCTGATTTC CACGCTTGCT ACCAAAATAG TCTGGGCAGG CCACTTTTGG AAGTAGGCGT 120 TATCTAGTGA GCAGGCGGCC GCTTTCGATT TCGCTTTCCC CTAAATGGCT GAGCTTCTCG ISO CCAGCGCAGG ATCAGCCTGT TCCTGGGACT TTCCGAGAGC CCCGCCCTCG TTCCCTCCCC 240 CAGCCGCCAG TAGGGGAGGA CTCGGCGGTA CCCGGAGCTT CAGGCCCCAC CGGGGCGCGG 300 AGAGTCCCAG ACCCGGCCGG GACCGGGACG GCGTCCGAGT GCCAATGGCT AGCTCTAGGT 360 GTCCCGCTCC CCGCGGGTGC CGCTGCCTCC CCGGAGCTTC TCTCGCATGG CTGGGGACAG 420 TACTGCTACT TCTCGCCGAC TGGGTGCTGC TCCGGACCGC GCTGCCCCGC ATATTCTCCC 480 TGCTGGTGCC CACCGCGCTG CCACTGCTCC GGGTCTGGGC GGTGGGCCTG AGCCGCTGGG 540 CCGTGCTCTG GCTGGGGGCC TGCGGGGTCC TCAGGGCAAC GGTTGGCTCC AAGAGCGAAA 600 ACGCAGGTGC CCAGGGCTGG CTGGCTGCTT TGAAGCCATT AGCTGCGGCA CTGGGCTTGG 660 CCCTGCCGGG ACTTGCCTTG TTCCGAGAGC TGATCTCATG GGGAGCCCCC GGGTCCGCGG 720 ATAGCACCAG GCTACTGCAC TGGGGAAGTC ACCCTACCGC CTTCGTTGTC AGTTATGCAG 780 CGGCACTGCC CGCAGCAGCC CTGTGGCACA AACTCGGGAG CCTCTGGGTG CCCGGCGGTC 840 AGGGCGGCTC TGGAAACCCT GTGCGTCGGC TTCTAGGCTG CCTGGGCTCG GAGACGCGCC 900 GCCTCTCGCT GTTCCTGGTC CTGGTGGTCC TCTCCTCTCT TGGGGAGATG GCCATTCCAT 960 TCTTTACGGG CCGCCTCACT GACTGGATTC TACAAGATGG CTCAGCCGAT ACCTTCACTC 1020 GAAACTTAAC TCTCATGTCC ATTCTCACCA TAGCCAGTGC AGTGCTGGAG TTCGTGGGTG 1080 ACGGGATCTA TAACAACACC ATGGGCCACG TGCACAGCCA CTTGCAGGGA GAGGTGTTTG 1140 GGGCTGTCCT GCGCCAGGAG ACGGAGTTTT TCCAACAGAA CCAGACAGGT AACATCATGT 1200 CTCGGGTAAC AGAGGACACG TCCACCCTGA GTGATTCTCT GAGTGAGAAT CTGAGCTTAT 1260 TTCTGTGGTA CCTGGTGCGA GGCCTATGTC TCTTGGGGAT CATGCTCTGG GGATCAGTGT 1320 CCCTCACCAT GGTCACCCTG ATCACCCTGC CTCTGCTTTT CCTTCTGCCC AAGAAGGTGG 1380 GAAAATGGTA CCAGTTGCTG GAAGTGCAGG TGCGGGAATC TCTGGCAAAG TCCAGCCAGG 1440 TGGCCATTGA GGCTCTGTCG GCCATGCCTA CAGTTCGAAG CTTTGCCAAC GAGGAGGGCG 1500 AAGCCCAGAA GTTTAGGGAA AAGCTGCAAG AAATAAAGAC ACTCAACCAG AAGGAGGCTG 1560 TGGCCTATGC AGTCAACTCC TGGACCACTA GTATTTCAGG TATGCTGCTG AAAGTGGGAA 1620 TCCTCTACAT TGGTGGGCAG CTGGTGACCA GTGGGGCTGT AAGCAGTGGG AACCTTGTCA 1680 CATTTGTTCT CTACCAGATG CAGTTCACCC AGGCTGTGGA GGTACTGCTC TCCATCTACC 1740 CCAGAGTACA GAAGGCTGTG GGCTCCTCAG AGAAAATATT TGAGTACCTG GACCGCACCC 1800 CTCGCTGCCC ACCCAGTGGT CTGTTGACTC CCTTACACTT GGAGGGCCTT GTCCAGTTCC 1860 AAGATGTCTC CTTTGCCTAC CCAAACCGCC CAGATGTCTT AGTGCTACAG GGGCTGACAT 1920 TCACCCTACG CCCTGGCGAG GTGACGGCGC TGGTGGGACC CAATGGGTCT GGGAAGAGCA 1980 CAGTGGCTGC CCTGCTGCAG AATCTGTACC AGCCCACCGG GGGACAGCTG CTGTTGGATG 2040 GGAAGCCCCT TCCCCAATAT GAGCACCGCT ACCTGCACAG GCAGGTGGCT GCAGTGGGAC 2100 AAGAGCCACA GGTATTTGGA AGAAGTCTTC AAGAAAATAT TGCCTATGGC CTGACCCAGA 2160

AGCCAACTAT GGAGGAAATC ACAGCTGCTG CAGTAAAGTC TGGGGCCCAT AGTTTCATCT 2220 CTGGACTCCC TCAGGGCTAT GACACAGAGG TAGACGAGGC TGGGAGCCAG CTGTCAGGGG 2280 GTCAGCGACA GGCAGTGGCG TTGGCCCGAG CATTGATCCG GAAACCGTGT GTACTTATCC 2340 TGGATGATGC CACCAGTGCC CTGGATGCAA ACAGCCAGTT ACAGGTGGAG CAGCTCCTGT 2400 ACGAAAGCCC TGAGCGGTAC TCCCGCTCAG TGCTTCTCAT CACCCAGCAC CTCAGCCTGG 2460 TGGAGCAGGC TGACCACATC CTCTTTCTGG AAGGAGGCGC TATCCGGGAG GGGGGAACCC 2520 ACCAGCAGCT CATGGAGAAA AAGGGGTGCT ACTGGGCCAT GGTGCAGGCT CCTGCAGATG 2580 CTCCAGAATG AAAGCCTTCT CAGACCTGCG CACTCCATCT CCCTCCCTTT TCTTCTCTCT 2640 GTGGTGGAGA ACCACAGCTG CAGAGTAGCA GCTGCCTCCA GGATGAGTTA CTTGAAATTT 2700 GCCTTGAGTG TGTTACCTCC TTTCCAAGCT CCTCGTGATA ATGCAGACTT CCTGGAGTAC 2760 AAACACAGGA TTTGTAATTC CTACTGTAAC GGAGTTTAGA GCCAGGGCTG ATGCTTTGGT 2820 GTGGCCAGCA CTCTGAAACT GAGAAATGTT CAGAATGTAC GGAAAGATGA TCAGCTATTT 2880 TCAACATAAC TGAAGGCATA TGCTGGCCCA TAAACACCCT GTAGGTTCTT GATATTTATA 2940 ATAAAATTGG TGTTTTGT 2958 Seq ID NO : 41 DNA Sequence Nucleic Acid Accession # : Nom 002423. 2 Coding sequence : 48.. 851 1 11 21 31 41 51 ACCAAATCAA CCATAGGTCC AAGAACAATT GTCTCTGGAC GGCAGCTATG CGACTCACCG 60 TGCTGTGTGC TGTGTGCCTG CTGCCTGGCA GCCTGGCCCT GCCGCTGCCT CAGGAGGCGG 120 GAGGCATGAG TGAGCTACAG TGGGAACAGG CTCAGGACTA TCTCAAGAGA TTTTATCTCT 180 ATGACTCAGA AACAAAAAAT GCCAACAGTT TAGAAGCCAA ACTCAAGGAG ATGCAAAAAT 240 TCTTTGGCCT ACCTATAACT GGAATGTTAA ACTCCCGCGT CATAGAAATA ATGCAGAAGC 300 CCAGATGTGG AGTGCCAGAT GTTGCAGAAT ACTCACTATT TCCAAATAGC CCAAAATGGA 360 CTTCCAAAGT GGTCACCTAC AGGATCGTAT CATATACTCG AGACTTACCG CATATTACAG 420 TGGATCGATT AGTGTCAAAG GCTTTAAACA TGTGGGGCAA AGAGATCCCC CTGCATTTCA 480 GGAAAGTTGT ATGGGGAACT GCTGACATCA TGATTGGCTT TGCGCGAGGA GCTCATGGGG 540 ACTCCTACCC ATTTGATGGG CCAGGAAACA CGCTGGCTCA TGCCTTTGCG CCTGGGACAG 600 GTCTCGGAGG AGATGCTCAC TTCGATGAGG ATGAACGCTG GACGGATGGT AGCAGTCTAG 660 GGATTAACTT CCTGTATGCT GCAACTCATG AACTTGGCCA TTCTTTGGGT ATGGGACATT 720 CCTCTGATCC TAATGCAGTG ATGTATCCAA CCTATGGAAA TGGAGATCCC CAAAATTTTA 780 AACTTTCCCA GGATGATATT AAAGGCATTC AGAAACTATA TGGAAAGAGA AGTAATTCAA 840 GAAAGAAATA GAAACTTCAG GCAGAACATC CATTCATTCA TTCATTGGAT TGTATATCAT 900 TGTTGCACAA TCAGAATTGA TAAGCACTGT TCCTCCACTC CATTTAGCAA TTATGTCACC 960 CTTTTTTATT GCAGTTGGTT TTTGAATGTC TTTCACTCCT TTTATTGGTT AAACTCCTTT 1020 ATGGTGTGAC TGTGTCTTAT TCCATCTATG AGCTTTGTCA GTGCGCGTAG ATGTCAATAA 1080 ATGTTACATA CACAAATAAA TAAAATGTTT ATTCCATGGT AAATTTA 1127 Seq ID NO : 42 DNA Sequence Nucleic Acid Accession # : NM018674 Coding sequence : 390.. 2009 1 11 21 31 41 51 1 1 1 1 1 1 CGGAGCACAT GCTGAGCGGA GCGGCTGGGG CTGCGCGGCG TGGCGGAGCA GCGCTCGCTC 60 CCTCGCTCAC TCGCTCGCTC GCAGGGACAC ACGCAGGGGC TGACAGCTGT GCTGGTGCTG 120 ATAAGGGAAG CCACAAGGAG ACGATCGAGG AGAGAGACAA GCGGCAGCAG AGGCAGCAGC 180 GGCAGAGGCA GCACCAGGGC TGCGGAGCTG CTGGGAGTGG GAGTGACTCC CCCACCTCGG 240 GCCCCCACCC TGTCCCTGTC CTCTTCCCGC TTGCCCTGAG TTTAGAAGAG CAGCCGCTGC 300 CACCACTGCC ACTCGGGAGG GCACCAGGGC TGCTGGCTAG GGAGGGACAG GGCAGGGAGG 360 CTCTGGCCAG TCCCAGCAGC CGGGGACAGA TGCCGATCGA GATTGTGTGC AAAATCAAAT 420 TTGCTGAGGA GGATGCGAAA CCCAAGGAGA AGGAGGCAGG GGATGAGCAG AGCCTCCTCG 480 GGGCTGTTGC CCCTGGAGCA GCCCCCCGAG ACCTGGCCAC CTTTGCCAGC ACCAGCACCC 540 TGCATGGACT GGGCCGGGCC TGTGGCCCAG GCCCCCACGG ACTGCGCAGA ACCCTGTGGG 600 CACTGGCCCT ACTCACCTCG CTGGCTGCCT TCCTGTACCA GGCGGCTGGC CTGGCCCGGG 660 GCTACCTGAC CCGGCCTCAC CTGGTGGCAA TGGACCCCGC TGCCCCAGCC CCAGTGGCGG 720 GCTTCCCGGC TGTCACCCTC TGCAATATCA ACCGCTTCCG GCATTCGGCA CTCAGCGATG 780 CCGACATCTT CCACCTGGCC AATCTGACAG GGCTGCCCCC CAAAGACCGG GATGGGCACC 840 GTGCGGCTGG CCTGCGCTAC CCAGAGCCTG ACATGGTAGA CATCCTCAAC CGCACTGGCC 900 ACCAGCTCGC CGACATGCTT AAGAGCTGCA ACTTCAGTGG GCATCACTGC TCCGCCAGCA 960 ACTTCTCTGT GGTCTATACT CGCTATGGGA AGTGTTACAC CTTCAACGCG GACCCGCGGA 1020 GCTCGCTGCC CAGCCGGGCA GGGGGCATGG GCAGTGGCCT GGAGATCATG CTGGACATCC 1080 AGCAGGAGGA GTACCTGCCC ATCTGGAGGG AGACAAATGA GACGTCGTTT GAGGCAGGTA 1140 TTCGGGTGCA GATCCACAGC CAGGAGGAGC CGCCCTACAT CCACCAGCTG GGGTTCGGGG 1200 TGTCCCCAGG CTTCCAGACC TTTGTGTCCT GCCAGGAACA GCGGCTGACC TACCTGCCCC 1260 AGCCCTGGGG CAACTGCCGC GCAGAGAGTG AGCTCAGGGA GCCTGAGCTT CAGGGCTACT 1320 CGGCCTACAG TGTGTCTGCC TGCCGGCTGC GCTGTGAAAA GGAGGCCGTG CTTCAGCGCT 1380 GCCACTGCCG GATGGTGCAC ATGCCAGGCA ATGAGACCAT CTGCCCACCA AATATCTACA 1440 TCGAGTGTGC AGACCACACA CTGGACTCCC TGGGTGGGGG CCCTGAGGGC CCGTGCTTCT 1500 GCCCCACCCC CTGCAACCTG ACACGCTATG GGAAAGAGAT CTCCATGGTC AGGATCCCCA 1560 ACAGGGGCTC AGCCCGGTAC CTGGCGAGGA AGTACAACCG CAACGAGACC TACATACGGG 1620 AGAACTTCCT GGTCCTAGAT GTCTTCTTTG AGGCCCTGAC CTCTGAAGCC ATGGAGCAGC 1680 GAGCAGCCTA TGGCCTGTCA GCCCTGCTGG GAGACCTCGG GGGACAGATG GGCCTGTTCA 1740 TTGGGGCCAG CATCCTCACG TTGCTGGAGA TCCTCGACTA CATCTATGAG GTGTCCTGGG 1800 ATCGACTGAA GCGGGTATGG AGGCGTCCCA AGACCCCCCT GCGGACCTCC ACTGGGGGCA 1860 TCTCCACTTT GGGGCTTCAG GAGCTGAAGG AACAGAGTCC CTGCCCGAGC CTGGGCCGAG 1920 CGGAGGGTGG GGGGGTCAGC AGTCTGCTCC CCAATCACCA CCACCCCCAC GGTCCCCCAG 1980 GAGGTCTCTT TGAAGATTTT GCTTGCTAGG ACGGTGCTGT GACTGAAAGG ACCCAGGAGT 2040 CTGGGACCCC TCCTGGGATC CCCAGCACAT TCTCCTGCTC CTGGGAGAGG CCTGGGGGCG 2100 GTGCTCACTG GGAGGGCCAG GACTCAGTTC CTGCTCTCAT CCTCCCCTGC CCTGATGTCA 2160 GCTGCTTTGC ACAAAGGTCC TTCTTGTCCA CACCCCTTAT CCCCAGGCTG GTGCCCCGGG 2220 AGGGCTGGAG ACCAGGCCAT GGGCCCTCAC GGAGAGGAAG GGAAGGAAGG AGAGGGAGGG 2280 GGAGGATAGA GCCCATCCCA GCCGGGGAGG GGGAGCCCTC TGTACATTTG TAAATATTTA 2340

GGGAAAGCCG GGTGGGGGGA GGGGATACAG ATGTAGAAGG TGGGTAGGGC TACAGGGGTG 2400 GGTGATTTAG GGACAGCCAG GGTCCCAGCC CCAATGTCAG CAGGATAGGG AGAGCCCCAG 2460 GACTCAGGAG TGCTGGGCTG GTCCTACTTC CTGCCCCTCT CCAGGCCCAG CTCCCCTCTT 2520 GGCAGGGGGA GAGGATGGCC CAGCAGGCCT GGCCCAGCTC CCAGTTCCCC CTGCACCAGC 2580 CCCACCCCTA GAGTCCCTTC TATAGGGAGG GGGCAGGAGA CCTTCCAGAC TTCGGCTGAG 2640 CTTGGAGGGT GGGAAGGGAG CCTTCTCAGT CCTCTCTCCC TCCAGTCTGA TTTTATAAAG 2700 TGCTGACGAG 2710 Seq ID NO : 43 DNA Sequence Nucleic Acid Accession # : AK091016 Coding sequence : 201.. 2291 1 11 21 31 41 51 GATCTCAGCT CCTTTTCAGC TAGTGGGTGG AACCCCAGGA GGGAAAACTC AGGGAAGCCC 60 AGGAGGAAGT GAAAATACCC CATGGAGTGA AGCTTGTGTG CTACCTGGGT TCCGGGCCAG 120 TGATCCAGCT CCTGGGGGGC ATCAGCCACG GCCAGGCAGG GGGGCAGCTG CCACCAAAGC 180 TGGAGGTTCT AGAGGACTTG ATGGAGGTCA GCTCACCCTC ACCTGCCCAG AGGCTCAGAA 240 GGAAGAAAAG GCCCATGGTG CAGGGCCCTG CTGGGTGCCA GGTTTTCCAG CCTTCTCCTT 300 CAGGAGGCAC AGCAGGGGAC CCTGGTGGCC TCTCTGACCC CTTCTACCCT CCAAGAAGCG 360 GTTCCCTGGC CCTTGGCGAC CCCAGCTCGG ACCCTGCATG TTCCCAGAGT GGCCCAATGG 420 AGGCTGAAGA GGATTCTCTT CCGGAGCAGC CAGAGGACTC AGCTCAGCTC CAACAGGAGA 480 AGCCATCCCT GTATATTGGG GTGCGGGGCA CTGTTGTCCG TTCCATGCAG GAGGTACTAT 540 GGACTCGCCT TCGGGAGCTC CCAGACCCAG TGCTGAGTGA GGAGGTGGTG GAGGGCATTG 600 CTGCTGGCAT TGAGGCAGCC CTCTGGGACC TGACACAAGG CACCAATGGC CGGTACAAGA 660 CCAAGTATCG CAGCCTGCTG TTCAACCTGC GGGACCCCAG GAACCTGGAC TTGTTTCTCA 720 AAGTGGTTCA TGGAGATGTC ACCCCCTACG ACCTGGTGCG GATGAGCTCG ATGCAGCTGG 780 CCCCCCAGGA GCTGGCCCGC TGGCGGGACC AGGAGGAGAA AAGGGGCCTG AATATCATTG 840 AGCAGCAACA GAAGGAGCCG TGCAGACTTC CAGCCTCCAA AATGACCCAC AAGGGCGAAG 900 TGGAGATTCA GCGGGACATG GACCAGACAC TGACCCTGGA GGATCTGGTG GGACCGCAGA 960 TGTTCATGGA CTGCAGCCCA CAGGCCCTGC CCATCGCATC AGAGGACACC ACGGGGCAGC 1020 ATGACCACCA CTTCTTAGAC CCCAACTGCC ACATCTGCAA GGACTGGGAG CCCTCGAATG 1080 AGCTGCTAGG CTCCTTCGAA GCCGCCAAGA GCTGCGGGGA CAATATCTTC CAGAAAGCCC 1140 TAAGCCAAAC TCCTATGCCT GCTCCAGAGA TGCCCAAAAC CAGGGAGTTG TCTCCCACGG 1200 AACCACAGGA CAGGGTCCCT CCATCTGGGC TCCATGTGCC TGCTGCACCC ACAAAGGCCC 1260 TGCCCTGCCT GCCACCCTGG GAAGGTGTTC TGGACATGTT CTCCATCAAG CGGTTCCGGG 1320 CCAGGGCCCA GCTGGTCTCG GGACACAGCT GTCGGCTTGT CCAGGCTCTG CCCACCGTGA 1380 TCCGCTCGGC AGGCTGCATC CCCTCCAACA TTGTCTGGGA CCTTCTGGCC AGCATCTGCC 1440 CAGCCAAGGC CAAGGACGTC TGCGTGGTCA GACTGTGCCC ACATGGGGCC CGGGACACCC 1500 AGAACTGCCG CCTGCTCTAC TCATACCTCA ATGATAGGCA GCGCCACGGG CTGGCCTCTG 1560 TGGAGCACAT GGGGATGGTC CTGCTGCCCC TGCCTGCCTT CCAGCCCCTG CCCACCAGGC 1620 TGCGCCCTTT GGGGGGCCCA GGTCTGGAGG TCACTCACTC AAGTCTGTTG CTGGCTGTGC 1680 TGCTCCCCAA GGAAGGGCTT CCAGACACAG CAGGGTCCAG CCCCTGGTTG GGGAAGGTTC 1740 AAAAGATGGT CTCCTTCAAC AGTAAGGTGG AGAAGAGATA CTATCAGCCA GATGACAGGA 1800 GGCCGAATGT GCCCCTGAAG GGCACCCCTC CCCCAGGAGG TGCCTGGCAG CAGAGCCAGG 1860 GCAGGGGCAG TATAGCTCCA AGGGGAATCT CTGCTTGGCA GAGGCCCCCC AGAGGCAGGG 1920 GGAGGCTCTG GCCAGAGCCT GAAAACTGGC AGCATCCTGG GCGAGGGCAG TGGCCCCCAG 1980 AGCCAGGCTT GCGCCAGTCC CAGCATCCCT ATTCAGTAGC ACCAGCTGGT CATGGCTTTG 2040 GCCGTGGCCA GCACTTCCAC AGGGACTCCT GTCCCCACCA AGCCCTGCTC CGGCACCTCG 2100 AATCCCTGGC GACCATGAGT CACCAGCTCC AAGCCTTACT GTGCCCCCAG ACCAAGAGCT 2160 CCATCCCCCG CCCTCTGCAG CGTTTGTCTA GCGCCCTTGC AGCTCCAGAG CCCCCTGGCC 2220 CAGCCCGTGA CTCCTCTTTG GGGCCTACAG ATGAAGCTGG CTCTGAGTGT CCCTTCCCTA 2280 GAAAGGCCTG ACCCTCCTTA CCCACCAGAA CAGGGGTTTT GATGCCCTCA CTAGTGTTGA 2340 AGCCTGTTCC AGAGAGAGGT GGGACTGCAA GGAGAGGATG GTCAGCCCTA CCCACCTGCC 2400 CTGTTTGAAC TTCCTGTTTG ACAATGTTTG CTGTTGATTT TTTGTTCAAT AAAGAATTTG 2460 GT 2462 Seq ID NO : 44 DNA Sequence Nucleic Acid Accession # : NM005291 Coding sequence : 75.. 1178 1 11 21 31 41 51 CCGACACCCA CGGGCGGAGA TCACCTGCTG CCCCGCAGAC CCCTGTCCCT TCCTCCCGGA 60 CCAGCAGCTA GAGGATGTCC AAACGGAGTT GGTGGGCTGG ATCCAGAAAG CCCCCAAGAG 120 AGATGCTGAA ACTCTCAGGC TCTGACTCCA GCCAAAGCAT GAATGGCCTT GAAGTGGCTC 180 CCCCAGGTCT GATCACCAAC TTCTCCCTGG CCACGGCAGA GCAATGTGGC CAGGAGACGC 240 CACTGGAGAA CATGCTGTTC GCCTCCTTCT ACCTTCTGGA TTTTATCCTG GCTTTAGTTG 300 GCAATACCCT GGCTCTGTGG CTTTTCATCC GAGACCACAA GTCCGGGACC CCGGCCAACG 360 TGTTCCTGAT GCATCTGGCC GTGGCCGACT TGTCGTGCGT GCTGGTCCTG CCCACCCGCC 420 TGGTCTACCA CTTCTCTGGG AACCACTGGC CATTTGGGGA AATCGCATGC CGTCTCACCG 480 GCTTCCTCTT CTACCTCAAC ATGTACGCCA GCATCTACTT CCTCACCTGC ATCAGCGCCG 540 ACCGTTTCCT GGCCATTGTG CACCCGGTCA AGTCCCTCAA GCTCCGCAGG CCCCTCTACG 600 CACACCTGGC CTGTGCCTTC CTGTGGGTGG TGGTGGCTGT GGCCATGGCC CCGCTGCTGG 660 TGAGCCCACA GACCGTGCAG ACCAACCACA CGGTGGTCTG CCTGCAGCTG TACCGGGAGA 720 AGGCCTCCCA CCATGCCCTG GTGTCCCTGG CAGTGGCCTT CACCTTCCCG TTCATCACCA 780 CGGTCACCTG CTACCTGCTG ATCATCCGCA GCCTGCGGCA GGGCCTGCGT GTGGAGAAGC 840 GCCTCAAGAC CAAGGCAGTG CGCATGATCG CCATAGTGCT GGCCATCTTC CTGGTCTGCT 900 TCGTGCCCTA CCACGTCAAC CGCTCCGTCT ACGTGCTGCA CTACCGCAGC CATGGGGCCT 960 CCTGCGCCAC CCAGCGCATC CTGGCCCTGG CAAACCGCAT CACCTCCTGC CTCACCAGCC 1020 TCAACGGGGC ACTCGACCCC ATCATGTATT TCTTCGTGGC TGAGAAGTTC CGCCACGCCC 1080 TGTGCAACTT GCTCTGTGGC AAAAGGCTCA AGGGCCCGCC CCCCAGCTTC GAAGGGAAAA 1140 CCAACGAGAG CTCGCTGAGT GCCAAGTCAG AGCTGTGAGC GGGGGGCGCC GTCCAGGCCG 1200 AGCGCAGACT GTTTAGGACT CAGCAGACCC AGCAAGAGGC ATCTGCCCTT TCCCCAGCCA 1260 CCTCCCCAGC AAGCAACCTG AAATCTCAGC AGATGCCCAC CATTTCTCTA GATCGCCTAG 1320 TCTCAACCCA TAAAAAGGAA GAACTGACAA AGGGGATCCA TCGGCCACCC CTCTGCAGGG 1380

GCTTGTGATG GCTACAATGG CTCCTAGACA CTCAACGACT TCATCTGTGG CAGGGAGAGA 1440 GGAGGCCGGA AGAACAACCC CTGAACAATG GAGGCCTTTC TTTCCCGCTA GGCTCCCAGC 1500 CTCCTTCCCG CTACAGAATC GCTCATCGGC GAGGCTCAGC AGAAAGACCC TGAAGGCAGG 1560 CTGCAAATGA CCCAGAAGAG GGACCTGGGA GTCCTGGTGG GGACGGGGAG GGAGTCTCAA 1620 TACTCCTTTG CAGCGCAAGG TACTCTGAGT CCCCTCTGTA GTGCCTCTGC CAGACACACA 1680 CTGCCTGAGT TGAAGAGACA CAGGCCACAC ATTTCAGGCT GGTTGCCAGC GGACGTCAGC 1740 ACTCACGGCC TGCGGGGACT CAGCACAGCT CTGGATTCTG GATCTCTCCT GCTGTAACCC 1800 CACGCACAAG CCTGCAACCC CCAGAGCTCT TTGACAGGCT CCCAGGCCTC CCAGTCCTGG 1860 ACAAGCATGT GCAGTCACGG GAGCTCAGCT CAGGCCAGGG CTGGGCTGTG CACCTGCCTC 1920 CCACTGACCC AGACCCACTT CCTCCAGAGA GGCCTCTCTC CGCCTGAGCT ATTTCCCTTG 1980 CTAGTGTGCA GATATTTCCC TAACATGTCC TTTTTTGTAT TTGTTTGTAC GGACCATAAA 2040 TATAACTGTA GCTTTAAGAC TAAAAAAAAA 2070 Seq ID NO : 45 DNA Sequence Nucleic Acid Accession # : NM 018643 Coding sequence : 48.. 752 1 11 21 31 41 51 CTACTACTAC TAAATTCGCG GCCGGTCGAC GCTGGTGCAC AGGAAGGATG AGGAAGACCA 60 GGCTCTGGGG GCTGCTGTGG ATGCTCTTTG TCTCAGAACT CCGAGCTGCA ACTAAATTAA 120 CTGAGGAAAA GTATGAACTG AAAGAGGGGC AGACCCTGGA TGTGAAATGT GACTACACGC 180 TAGAGAAGTT TGCCAGCAGC CAGAAAGCTT GGCAGATAAT AAGGGACGGA GAGATGCCCA 240 AGACCCTGGC ATGCACAGAG AGGCCTTCAA AGAATTCCCA TCCAGTCCAA GTGGGGAGGA 300 TCATACTAGA AGACTACCAT GATCATGGTT TACTGCGCGT CCGAATGGTC AACCTTCAAG 360 TGGAAGATTC TGGACTGTAT CAGTGTGTGA TCTACCAGCC TCCCAAGGAG CCTCACATGC 420 TGTTCGATCG CATCCGCTTG GTGGTGACCA AGGGTTTTTC AGGGACCCCT GGCTCCAATG 480 AGAATTCTAC CCAGAATGTG TATAAGATTC CTCCTACCAC CACTAAGGCC TTGTGCCCAC 540 TCTATACCAG CCCCAGAACT GTGACCCAAG CTCCACCCAA GTCAACTGCC GATGTCTCCA 600 CTCCTGACTC TGAAATCAAC CTTACAAATG TGACAGATAT CATCAGGGTT CCGGTGTTCA 660 ACATTGTCAT TCTCCTGGCT GGTGGATTCC TGAGTAAGAG CCTGGTCTTC TCTGTCCTGT 720 TTGCTGTCAC GCTGAGGTCA TTTGTACCCT AGGCCCACGA ACCCACGAGA ATGTCCTCTG 780 ACTTCCAGCC ACATCCATCT GGCAGTTGTG CCAAGGGAGG AGGGAGGAGG TAAAAGGCAG 840 GGAGTTAATA ACATGAATTA AATCTGTAAT CACCAGCTAT TTCT 884 Seq ID NO : 46 DNA Sequence Nucleic Acid Accession # : NM003467 Coding sequence : 1.. 1059 1 11 21 31 41 51 ATGGAGGGGA TCAGTATATA CACTTCAGAT AACTACACCG AGGAAATGGG CTCAGGGGAT 60 TATGACTCCA TGAAGGAACC CTGTTTCCGT GAAGAAAATG CTAATTTCAA TAAAATCTTC 120 CTGCCCACCA TCTACTCCAT CATCTTCTTA ACTGGCATTG TGGGCAATGG ATTGGTCATC 180 CTGGTCATGG GTTACCAGAA GAAACTGAGA AGCATGACGG ACAAGTACAG GCTGCACCTG 240 TCAGTGGCCG ACCTCCTCTT TGTCATCACG CTTCCCTTCT GGGCAGTTGA TGCCGTGGCA 300 AACTGGTACT TTGGGAACTT CCTATGCAAG GCAGTCCATG TCATCTACAC AGTCAACCTC 360 TACAGCAGTG TCCTCATCCT GGCCTTCATC AGTCTGGACC GCTACCTGGC CATCGTCCAC 420 GCCACCAACA GTCAGAGGCC AAGGAAGCTG TTGGCTGAAA AGGTGGTCTA TGTTGGCGTC 480 TGGATCCCTG CCCTCCTGCT GACTATTCCC GACTTCATCT TTGCCAACGT CAGTGAGGCA 540 GATGACAGAT ATATCTGTGA CCGCTTCTAC CCCAATGACT TGTGGGTGGT TGTGTTCCAG 600 TTTCAGCACA TCATGGTTGG CCTTATCCTG CCTGGTATTG TCATCCTGTC CTGCTATTGC 660 ATTATCATCT CCAAGCTGTC ACACTCCAAG GGCCACCAGA AGCGCAAGGC CCTCAAGACC 720 ACAGTCATCC TCATCCTGGC TTTCTTCGCC TGTTGGCTGC CTTACTACAT TGGGATCAGC 780 ATCGACTCCT TCATCCTCCT GGAAATCATC AAGCAAGGGT GTGAGTTTGA GAACACTGTG 840 CACAAGTGGA TTTCCATCAC CGAGGCCCTA GCTTTCTTCC ACTGTTGTCT GAACCCCATC 900 CTCTATGCTT TCCTTGGAGC CAAATTTAAA ACCTCTGCCC AGCACGCACT CACCTCTGTG 960 AGCAGAGGGT CCAGCCTCAA GATCCTCTCC AAAGGAAAGC GAGGTGGACA TTCATCTGTT 1020 TCCACTGAGT CTGAGTCTTC AAGTTTTCAC TCCAGCTAA 1059 Seq ID NO : 47 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 GTGTGTAGTC GGGTATGAGA ACGATTGCAA GCAAAAGCAG CTGAGGGACG CTGTCCAAGG 60 AGTAGGCTCA GTAGCACGAA CTGCAAATAC TTGAGAAGGG AAAAGTTCAG CCTTGTGCTG 120 GAAAGTGGTT TAGCATGCTG GAGCTGGTTT TCTGCTTGGT AGCCCTACAA CTTTGGCCCA 180 ACTACTTGGC CTCTGGGACT CAGATTCCTC CTCTTTAAAA TGGTGCTAAT AATAGCACCC 240 ACCCTCTGTG AGGAGGATGC TGTGAGGACA AAATGAGATC ATCCACATAA GCCGTGAACC 300 CTGTTCCTGG TAAGCTCCTG GAAAGAAGTC TATGGATTAT ACTCAACCTA CACTCCAGTT 360 AAAGGAACAT CTACACACAG AGGAAATGAA TAACATGAAG TGAAGTCTTC ATCTCCATTC 420 CCAACAGTCC CCATTCTACT TGCAGAAAGG TTGCTTACAC TGAAAATCAG TTTATTTTCC 480 CCTGGTGCAA AGAACAGTCG TTTCTCCAAA ACTGAAGCTG GAAATTATCT GAAATATCAG 540 GTCCTCCGGA AAAGGGACGT GAAGCCCCCT TTGTAATTTC TGCATTAGCG TGCTCTCCTG 600 GCAAGCAGGA AACCTCATCA GAGAAGTCAG CCAAGGAAAG TCTTTAAATG GAAATTGTGC 660 AAACGAGGAG CAAATGCATT AAAAAGTTGC TGACGGGCAT GAAATGCTTT GATGTGAAGA 720 CGGAAAACTC CAAGCAGGAA GGATTTTAAC ATTTTGAATC TGATTGACTC TGTGGTTTCT 780 CAGCACAGTT ATTCCATGGG CTAAAATAAA TGCAGAAATG GTACTTTCAG ACCACAGCTG 840 CAGAGGGGAT CGTGGTGAAT TTCAATGAAA ATCCATTTGA ATCTTGAGGT TCAGATCTTA 900 AAAAAGCAAA GGACATGAGA GAAGTAATAT TGTTGCTTGA AATTTCATTG CTTATATCTA 960 AAAGAAACTC CTATTTTTAA GAGAAATGTT GAATCTTTGC AACGTGGTAG ACGCTCCCAC 1020 AAAACTTTCT CCTGAAATAG GAGATAAATG TTGGAAAGAG GCAATGTATT GAGTATGCTG 1080 ATAGAGGTGG AGTTCAGAGA CAGGCAAGCA TACATAAGAG TCAGGATGTT TTTCAGTATT 1140 ATCTTTACAA ATGAGTTTCT TACAGTGGTC AATGACAAAC CAATTTCATT CAAAGCTTGC 1200 TTCAATAGGC AATGGTTTGA TGCCAATATG TTAGCTATTT ACTTTGACCA CCGTATGCAT 1260 TAAAAAGAAG AAAAATTAAG AATACTCAAG CAGAACCTCC AACTTAGATA GCACTTTCCA 1320

CAAAAAGTAA TGGAGGGATA GACTGAAGTT AAATGGGATC AGGTATGTGA TGAGATCTCA 1380 GAAGTGTTTG CACAATAATG CAGATACTCA TTTTAAACAG AGTCATAAGG ATTGGAACTA 1440 ATAAAAATAA TAGAATAAAA TACCGATCAA GAATGTGTCC TCCTGCGTAT CTGGGTTTTG 1500 AATTCTGGCT CCACAGAACT TGTCAGATAT ATGACATTAA AC 1542 Seq ID NO : 48 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 52.. 1131 1 11 21 31 41 51 ATGCATCCTC AAGTGGTCAT CTTAAGCCTC ATCCTACATC TGGCAGATTC TGTAGCTGGT 60 TCTGTAAAGG TTGGTGGAGA GGCAGGTCCA TCTGTCACAC TACCCTGCCA CTACAGTGGA 120 GCTGTCACAT CAATGTGCTG GAATAGAGGC TCATGTTCTC TATTCACATG CCAAAATGGC 180 ATTGTCTGGA CCAATGGAAC CCACGTCACC TATCGGAAGG ACACACGCTA TAAGCTATTG 240 GGGGACCTTT CAAGAAGGGA TGTCTCTTTG ACCATAGAAA ATACAGCTGT GTCTGACAGT 300 GGCGTATATT GTTGCCGTGT TGAGCACCGT GGGTGGTTCA ATGACATGAA AATCACCGTA 360 TCATTGGAGA TTGTGCCACC CAAGGTCACG ACTACTCCAA TTGTCACAAC TGTTCCAACC 420 GTCACGACTG TTCGAACGAG CACCACTGTT CCAACGACAA CGACTGTTCC AACGACAACT 480 GTTCCAACAA CAATGAGCAT TCCAACGACA ACGACTGTTC CGACGACAAT GACTGTTTCA 540 ACGACAACGA GCGTTCCAAC GACAACGAGC ATTCCAACAA CAACAAGTGT TCCAGTGACA 600 ACAACGGTCT CTACCTTTGT TCCTCCAATG CCTTTGCCCA GGCAGAACCA TGAACCAGTA 660 GCCACTTCAC CATCTTCACC TCAGCCAGCA GAAACCCACC CTACGACACT GCAGGGAGCA 720 ATAAGGAGAG AACCCACCAG CTCACCATTG TACTCTTACA CAACAGATGG GAATGACACC 780 GTGACAGAGT CTTCAGATGG CCTTTGGAAT AACAATCAAA CTCAACTGTT CCTAGAACAT 840 AGTCTACTGA CGGCCAATAC CACTAAAGGA ATCTATGCTG GAGTCTGTAT TTCTGTCTTG 900 GTGCTTCTTG CTCTTTTGGG TGTCATCATT GCCAAAAAGT ATTTCTTCAA AAAGGAGGTT 960 CAACAACTAA GTGTTTCATT TAGCAGCCTT CAAATTAAAG CTTTGCAAAA TGCAGTTGAA 1020 AAGGAAGTCC AAGCAGAAGA CAATATCTAC ATTGAGAATA GTCTTTATGC CACGGACTAA 1080 Seq ID NO : 49 DNA Sequence Nucleic Acid Accession # : NM 004932. 2 Coding sequence : 327.. 2699 1 11 21 31 41 51 ACTTCATTCA CTTGCAAATC AGTGTGTGCC CACAAGAGCC AGCTCTCCCG AGCCCGTAAC 60 CTTCGCATCC CAAGAGCTGC AGTTTCAGCC GCGACAGCAA GAACGGCAGA GCCGGCGACC 120 GCGGCGGCGG CGGCGGCGGA GGCAGGAGCA GCCTGGGCGG GTCGCAGGGT CTCCGCGGGC 180 GCAGGAAGGC GAGCAGAGAT ATCCTCTGAG AGCCAAGCAA AGAACATTAA GGAAGGAAGG 240 AGGAATGAGG CTGGATACGG TGCAGTGAAA AAGGCACTTC CAAGAGTGGG GCACTCACTA 300 CGCACAGACT CGACGGTGCC ATCAGCATGA GAACTTACCG CTACTTCTTG CTGCTCTTTT 360 GGGTGGGCCA GCCCTACCCA ACTCTCTCAA CTCCACTATC AAAGAGGACT AGTGGTTTCC 420 CAGCAAAGAA AAGGGCCCTG GAGCTCTCTG GAAACAGCAA AAATGAGCTG AACCGTTCAA 480 AAAGGAGCTG GATGTGGAAT CAGTTCTTTC TCCTGGAGGA ATACACAGGA TCCGATTATC 540 AGTATGTGGG CAAGTTACAT TCAGACCAGG ATAGAGGAGA TGGATCACTT AAATATATCC 600 TTTCAGGAGA TGGAGCAGGA GATCTCTTCA TTATTAATGA AAACACAGGC GACATACAGG 660 CCACCAAGAG GCTGGACAGG GAAGAAAAAC CCGTTTACAT CCTTCGAGCT CAAGCTATAA 720 ACAGAAGGAC AGGGAGACCC GTGGAGCCCG AGTCTGAATT CATCATCAAG ATCCATGACA 780 TCAATGACAA TGAACCAATA TTCACCAAGG AGGTTTACAC AGCCACTGTC CCTGAAATGT 840 CTGATGTCGG TACATTTGTT GTCCAAGTCA CTGCGACGGA TGCAGATGAT CCAACATATG 900 GGAACAGTGC TAAAGTTGTC TACAGTATTC TACAGGGACA GCCCTATTTT TCAGTTGAAT 960 CAGAAACAGG TATTATCAAG ACAGCTTTGC TCAACATGGA TCGAGAAAAC AGGGAGCAGT 1020 ACCAAGTGGT GATTCAAGCC AAGGATATGG GCGGCCAGAT GGGAGGATTA TCTGGGACCA 1080 CCACCGTGAA CATCACACTG ACTGATGTCA ACGACAACCC TCCCCGATTC CCCCAGAGTA 1140 CATACCAGTT TAAAACTCCT GAATCTTCTC CACCGGGGAC ACCAATTGGC AGAATCAAAG 1200 CCAGCGACGC TGATGTGGGA GAAAATGCTG AAATTGAGTA CAGCATCACA GACGGTGAGG 1260 GGCTGGATAT GTTTGATGTC ATCACCGACC AGGAAACCCA GGAAGGGATT ATAACTGTCA 1320 AAAAGCTCTT GGACTTTGAA AAGAAGAAAG TGTATACCCT TAAAGTGGAA GCCTCCAATC 1380 CTTATGTTGA GCCACGATTT CTCTACTTGG GGCCTTTCAA AGATTCAGCC ACGGTTAGAA 1440 TTGTGGTGGA GGATGTAGAT GAGCCACCTG TCTTCAGCAA ACTGGCCTAC ATCTTACAAA 1500 TAAGAGAAGA TGCTCAGATA AACACCACAA TAGGCTCCGT CACAGCCCAA GATCCAGATG 1560 CTGCCAGGAA TCCTGTCAAG TACTCTGTAG ATCGACACAC AGATATGGAC AGAATATTCA 1620 ACATTGATTC TGGAAATGGT TCGATTTTTA CATCGAAACT TCTTGACCGA GAAACACTGC 1680 TATGGCACAA CATTACAGTG ATAGCAACAG AGATCAATAA TCCAAAGCAA AGTAGTCGAG 1740 TACCTCTATA TATTAAAGTT CTAGATGTCA ATGACAACGC CCCAGAATTT GCTGAGTTCT 1800 ATGAAACTTT TGTCTGTGAA AAAGCAAAGG CAGATCAGTT GATTCAGACC CTGCATGCTG 1860 TTGACAAGGA TGACCCTTAT AGTGGACACC AATTTTCGTT TTCCTTGGCC CCTGAAGCAG 1920 CCAGTGGCTC AAACTTTACC ATTCAAGACA ACAAAGACAA CACGGCGGGA ATCTTAACTC 1980 GGAAAAATGG CTATAATAGA CACGAGATGA GCACCTATCT CTTGCCTGTG GTCATTTCAG 2040 ACAACGACTA CCCAGTTCAA AGCAGCACTG GGACAGTGAC TGTCCGGGTC TGTGCATGTG 2100 ACCACCACGG GAACATGCAA TCCTGCCATG CGGAGGCGCT CATCCACCCC ACGGGACTGA 2160 GCACGGGGGC TCTGGTTGCC ATCCTTCTGT GCATCGTGAT CCTACTAGTG ACAGTGGTGC 2220 TGTTTGCAGC TCTGAGGCGG CAGCGAAAAA AAGAGCCTTT GATCATTTCC AAAGAGGACA 2280 TCAGAGATAA CATTGTCAGT TACAACGACG AAGGTGGTGG AGAGGAGGAC ACCCAGGCTT 2340 TTGATATCGG CACCCTGAGG AATCCTGAAG CCATAGAGGA CAACAAATTA CGAAGGGACA 2400 TTGTGCCCGA AGCCCTTTTC CTACCCCGAC GGACTCCAAC AGCTCGCGAC AACACCGATG 2460 TCAGAGATTT CATTAACCAA AGGTTAAAGG AAAATGACAC GGACCCCACT GCCCCGCCAT 2520 ACGACTCCTT GGCCACTTAC GCCTATGAAG GCACTGGCTC CGTGGCGGAT TCCCTGAGCT 2580 CGCTGGAGTC AGTGACCACG GATGCAGATC AAGACTATGA TTACCTTAGT GACTGGGGAC 2640 CTCGATTCAA AAAGCTTGCA GATATGTATG GAGGAGTGGA CAGTGACAAA GACTCCTAAT 2700 CTGTTGCCTT TTTCATTTTC CAATACGACA CTGAAATATG TGAAGTGGCT ATTTCTTTAT 2760 ATTTATCCAC TACTCCGTGA AGGCTTCTCT GTTCTACCCG TTCCAAAAGC CAATGGCTGC 2820 AGTCCGTGTG GATCCAATGT TAGAGACTTT TTTCTAGTAC ACTTTTATGA GCTTCCAAGG 2880 GGCAAATTTT TATTTTTTAG TGCATCCAGT TAACCAAGTC AGCCCAACAG GCAGGTGCCG 2940 GAGGGGAGGA CAGGGAACAG TATTTCCACT TGTTCTCAGG GCAGCGTGCC CGCTTCCGCT 3000

GTCCTGGTGT TTTACTACAC TCCATGTCAG GTCAGCCAAC TGCCCTAACT GTACATTTCA 3060 CAGGCTAATG GGATAAAGGA CTGTGCTTTA AAGATAAAAA TATCATCATA GTAAAAGAAA 3120 TGAGGGCATA TCGGCTCACA AAGAGATAAA CTACATAGGG GTGTTTATTT GTGTCACAAA 3180 GAATTTAAAA TAACACTTGC CCATGCTATT TGTTCTTCAA GAACTTTCTC TGCCATCAAC 3240 TACTATTCAA AACCTCAAAT CCACCCATAT GTTAAAATTC TCATTACTCT TAAGGAATAG 3300 AAGCAAATTA AACGGTAACA TCCAAAAGCA ACCACAAACC TAGTACGACT TCATTCCTTC 3360 CACTAACTCA TAGTTTGTTA TATCCTAGAC TAGACATGCG AAAGTTTGCC TTTGTACCAT 3420 ATAAAGGGGG AGGGAAATAG CTAATAATGT TAACCAAGGA AATATATTTT ACCATACATT 3460 TAAAGTTTTG GCCACCACAT GTATCACGGG TCACTTGAAA TTCTTTCAGC TATCAGTAGG 3540 CTAATGTCAA AATTGTTTAA AAATTCTTGA AAGAATTTTC CTGAGACAAA TTTTAACTTC 3600 TTGTCTATAG TTGTCAGTAT TATTCTACTA TACTGTACAT GAAAGTAGCA GTGTGAAGTA 3660 CAATAATTCA TATTCTTCAT ATCCTTCTTA CACGACTAAG TTGAATTAGT AAAGTTAGAT 3720 TAAATAAAAC TTAAATCTCA CTCTAGGAGT TCAGTGGAGA GGTTAGAGCC AGCCACACTT 3780 GAACCTAATA CCCTGCCCTT GACATCTGGA AACCTCTACA TATTTATATA ACGTGATACA 3840 TTTGGATAAA CAACATTGAG ATTATGATGA AAACCTACAT ATTCCATGTT TGGAAGACCC 3900 TTGGAAGAGG AAAATTGGAT TCCCTTAAAC AAAAGTGTTT AAGATTGTAA TTAAAATGAT 3960 AGTTGATTTT CAAAAGCATT AATTTTTTTT CATTGTTTTT AACTTTGCTT TCATGACCAT 4020 CCTGCCATCC TTGACTTTGA ACTAATGATA AAGTAATGAT CTCAAACTAT GACAGAAAAG 4080 TAATGTAAAA TCCATCCAAT CTATTATTTC TCTAATTATG CAATTAGCCT CATAGTTATT 4140 ATCCAGAGGA CCCAACTGAA CTGAACTAAT CCTTCTGGCA GATTCAAATC GTTTATTTCA 4200 CACGCTGTTC TAATGGCACT TATCATTAGA ATCTTACCTT GTGCAGTCAT CAGAAATTCC 4260 AGCGTACTAT AATGAAAACA TCCTTGTTTT GAAAACCTAA AAGACAGGCT CTGTATATAT 4320 ATATACTTAA GAATATGCTG ACTTCACTTA TTAGTCTTAG GGATTTATTT TCAATTAATA 4380 TTAATTTTCT ACAAATAATT TTAGTGTCAT TTCCATTTGG GGATATTGTC ATATCAGCAC 4440 ATATTTTCTG TTTGGAAACA CACTGTTGTT TAGTTAAGTT TTAAATAGGT GTATTACCCA 4500 AGAAGTAAAG ATGGAAACGT T 4521 Seq ID NO : 50 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TTTTTTTTTT TTTTTAGAAA AAAACCAGTT TATTAAGTAA TATCATATAA ATAACTTGTT 60 ACAAAAATTG ATTTGCAAAA GGCATATTTA CTCTTTGTGA GAAATCACTT TTTAAATTGC 120 ATTCTTTTCA AATTTATAAG TCTAAGAAAA CAAAACCAAA TAAAAGAAGC CATTTCAAGG 180 AGTGCGTATT TGCCATTTGA CTGCAACAAA AGGCCCGGCC ACACTGAGCT AAAAGGTAAT 240 ACTCTCGACC CCATTCTTCT AACACAGAAA ACTTTCTCAG GTAAACTGTG GGGTTATGAG 300 AATCCCCCTA ACTAGAAATG TTGATGGGAA CTGAGCATTG CTTGCTTTCA TCAGGTGTTC 360 TTGTTGCCAA AGACATGAAC GATACTGAGG AAAACGACAA GAGTGAGCAT TCCCGCCAGT 420 AAATCTTCAA GGGTGGCATC CGTTTCAATT TATACTTGGA AGTATTTTTA ATTAAAAACA 480 ATCAATACCA AAAAGCTTTT ATTTTGTGGG TTTAAAAGTC ACAAATCACA GTGGGAGAAT 540 GCCAAATTGC TTTAGCTTGG AACTACTGAA GACGCACATA GCATTTATTA TAAGGCCTAC 600 TCTTAGGCAG TTCACTCTCA AAGCAATGAA AATAATCTCA AACCAAACAT TACAGTGGGT 660 TTGAAGCGTT CCTACGTTTC TTCCGAGCAG GTCAGTTTTA CATTTGCTAC ACAGCATTCC 720 CCACGAATGC CTGGTAATTC TATACATTTG ATTCTTTAAT AAACACTAAA CTAATAGATC 780 ATAGAAAACT AAAAGCTTAG AGAAGGTGCC TCCAGACATA TTTACATAAA TAACGTAGCC 840 TCACAAGAAA GACCAAGATC TCATTAGCGT GGAATGCTTT TTCCACAAGG CTGGGTCCAT 900 GCCTCATTTG TCAGATTAAC CCCATTTGAG GAGAAATTTG AGTTTGTGGT TCATGGGTTT 960 TTGAAAAAAA AAAAAAAAAA AAAATTAAGC AACTTGTAAA AGCTCTTTTG AAATTAATCT 1020 AATAACCCAG TGGCTCCTCG GCTAAGTGCC TCAGTCCTGT CTGAAATACA GCGGGTAAGA 1080 GCCTTTGTTT CCATTTGACC TCTTTTCAAC ACTTTCATCT GCCGGCTCTG TTGGGCTAAC 1140 GTTTCCCCCA AATAAAAATG AAAATGCACC ATAAATAAGG TATTACAAAA AGGGGAGTAG 1200 ATTAAAGATT GTCTCAGCAA TGCTTAAATT AAATTGACGA TGCAGAGACC ATAAACTTCC 1260 GGCTTTAAAA ATGAGCTATT TCTTTATTAA CTTTTAACAA GTGTATGAGT CAATGTATTT 1320 TCTTTCTAAG AGGGTATTGC TCTCCACATT AAATATGGTC GGGGTCTGAT ATTTTTAGTA 1380 GAGAATTACC CTTTAGAAAA TTATTCCATA AAGATGCCAT AGGGAGATTA AAAATGCTGT 1440 GACCATAAGA GCTACTAAAC ATTTAAGGAG ACCATAATAT AATTCTATAT TCTCTGGAAA 1500 AGGAAGCTGC TTGTTTGAGC TTATGAAATA GCTCATTTTC CTGAAGATTC ACACACCAAG 1560 TGTTAATTTT TCTACTCTTA TAATCTGATA AGGAAGGTTG TGGTGTTAAT TTAAACACAG 1620 TAGACTGCTT GGATTTTTGA GTCCCCTTTT ATAATATCAC AATTCAAACA AGATTTCATC 1680 TTGATAAACA TAAAAATTAA GATTACACTA TAATGATCCT TGTTAGAGGA TACATTTCAA 1740 AATAGTGGGG GAATCATGAC TTTTTAGAGC CTTCTTCCAG AGTAATTACA CTGCTTCAAA 1800 ACTAGTTATT AGGATAAAAT AATTTATTTG GTGGTCTGTT CCTGGTGAAA ATGAATTTAG 1860 CTGATAAGGA TGAGTACCTG ATTTGAATAT TTAGTTGGCA CCCAGGAGTC AACTTTGATT 1920 TTCTTTTCAA CTGCATACTT TTTATGGTGC TTGAGTATAT AGAATTGTCC AAGTCATAGT 1980 TTACACACCA CTATCCCCAG TGGGATATCT ATTTCCAGGC AAAGCATTTG ATGTGAGATA 2040 TTGTTCAGCC AATCAGGACA CTTAAAATTT ATATATGTAA AAGTGAAAGT AATAGAAACA 2100 TTCTAAAGTT AATTTGGATT TATAAAATTT GGATGGCCTA AGCTACAGAT TCAATTTTTA 2160 AGGCCGGGCG CGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCG AGGCGGGAGA 2220 ATGGCGTGAA CCCGGGAGGC GGAGCTTGTA GTGAGCAGAG ATCGCGCCAC TGCATTCCAG 2280 CCTGGGCGAC AGAGCGAGAT TCTGTCTCAA AAAAAAAAAA AAAAAGAAAC TTATCGATAC 2340 CCC 2343 Seq ID NO : 51 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 640.. 2313 1 11 21 31 41 51 GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60 GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120 GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180 CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGCCTCGTGC TCCTCCCGGG 240 GTGCTTGGCA CAGCCTCGGA TTCCTCCCTC TCGCTGCTCG AGTCAGTTTC CCTATCGGCG 300 GCAGCGGGCA AGGCGGCGGC GGCGGCGGCG GCAGCCGCGG TGGCGGCGTG GGGAACATCT 360 CGGCAGCCAC CGCGCTTCTC CCGCTGGAGC GGGCGTCCAG CTTGGCTGCC CTCGGTCCTT 420

CCCTGCCACG TTTCGGGTCG CCCTGCACCC CCCACCCAGG CTCGCTTCTC TTCGAAGCGG 480 GAAGGGCGCC TTGCAGGATC CTGCCGCCCC TCCAACCGGA TCCTGGGTCT AGAGCTCCCC 540 AGAGCGAGGC GCTCGCCAGG ACTCCTGCCC CGCCAACCCT GACCGCCGGG GGGTGCCCCC 600 GGGACGTAGC GCCGCGGAGA GGAAGCGGCA AAGGGGACCA TGCGGCGCCT GACTCGTCGG 660 CTGGTTCTGC CAGTCTTCGG GGTGCTCTGG ATCACGGTGC TGCTGTTCTT CTGGGTAACC 720 AAGAGGAAGT TGGAGGTGCC GACGGGACCT GAAGTGCAGA CCCCTAAGGT TTGGTCCTTG 780 TTTTTCAAGG TGGCTGGGAT GAGCCCTTGG GCGCCTCAGG TGCCTGTATC ACCCACTCCT 840 CCCTACCAAA GAGGGCATCT TCCTACAGGA GGACACCTTG CTGTATGTCA TTTCCCATGT 900 CTCTTGCAAG AAGCTCAGTT CCATTTGCAG ACTCAGGTCT TTCTTCAAGT CAGATGCACA 960 CTGCTGGTGT ATTGCACGGA CCTTCCACCC ACTAGCATCA TCATCACCTT CCACAACGAG 1020 GCCCGCTCCA CGCTGCTCAG GACCATCCGC AGTGTATTAA ACCGCACCCC TACGCATCTG 1080 ATCCGGGAAA TCATATTAGT GGATGACTTC AGCAATGACC CTGATGACTG TAAACAGCTC 1140 ATCAAATTGC CCAAGGTGAA ATGCTTGCGC AATAATGAAC GGCAAGGTCT GGTCCGGTCC 1200 CGGATTCGGG GCGCTGACAT CGCCCAGGGC ACCACTCTGA CTTTCCTCGA CAGCCACTGT 1260 GAGGTGAACA GGGACTGGCT CCAGCCTCTG TTGCACAGGG TCAAAGAGGA CTACACGCGG 1320 GTGGTGTGCC CTGTGATCGA TATCATTAAC CTGGACACCT TCACCTACAT CGAGTCTGCC 1380 TCGGAGCTCA GAGGGGGGTT TGACTGGAGC CTCCACTTCC AGTGGGAGCA GCTCTCCCCA 1440 GAGCAGAAGG CTCGGCGCCT GGACCCCACG GAGCCCATCA GGACTCCTAT CATAGCTGGA 1500 GGGCTCTTCG TGATCGACAA AGCTTGGTTT GATTACCTGG GGAAATATGA TATGGACATG 1560 GACATCTGGG GTGGGGAGAA CTTTGAAATC TCCTTCCGAG TGTGGATGTG CGGGGGCAGC 1620 CTAGAGATCG TCCCCTGCAG CCGAGTGGGG CACGTCTTCC GGAAGAAGCA CCCCTACGTT 1680 TTCCCTGATG GAAATGCCAA CACGTATATA AAGAACACCA AGCGGACAGC TGAAGTGTGG 1740 ATGGATGAAT ACAAGCAATA CTATTACGCT GCCCGGCCAT TCGCCCTGGA GAGGCCCTTC 1800 GGGAATGTTG AGAGCAGATT GGACCTGAGG AAGAATCTGC GCTGCCAGAG CTTCAAGTGG 1860 TACCTGGAGA ATATCTACCC TGAACTCAGC ATCCCCAAGG AGTCCTCCAT CCAGAAGGGC 1920 AATATCCGAC AGAGACAGAA GTGCCTGGAA TCTCAAAGGC AGAACAACCA AGAAACCCCA 1980 AACCTAAAGT TGAGCCCCTG TGCCAAGGTC AAAGGCGAAG ATGCAAAGTC CCAGGTATGG 2040 GCCTTCACAT ACACCCAGCA GATCCTCCAG GAGGAGCTGT GCCTGTCAGT CATCACCTTG 2100 TTCCCTGGCG CCCCAGTGGT TCTTGTCCTT TGCAAGAATG GAGATGACCG ACAGCAATGG 2160 ACCAAAACTG GTTCCCACAT CGAGCACATA GCATCCCACC TCTGCCTCGA TACAGATATG 2220 TTCGGTGATG GCACCGAGAA CGGCAAGGAA ATCGTCGTCA ACCCATGTGA GTCCTCACTC 2280 ATGAGCCAGC ACTGGGACAT GGTGAGCTCT TGAGGACCCC TGCCAGAAGC AGCAAGGGCC 2340 ATGGGGTGGT GCTTCCCTGG ACCAGAACAG ACTGGAAACT GGGCAGCAAG CAGCCTGCAA 2400 CCACCTCAGA CATCCTGGAC TGGGAGGTGG AGGCAGAGCC CCCCAGGACA GGAGCAACTG 2460 TCTCAGGGAG GACAGAGGAA AACATCACAA GCCAATGGGG CTCAAAGACA AATCCCACAT 2520 GTTCTCAAGG CCGTTAAGTT CCAGTCCTGG CCAGTCATTC CCTGATTGGT ATCTGGAGAC 2580 AGAAACCTAA TGGGAAGTGT TTATTGTTCC TTTTCCTACA AAGGAAGCAG TCTCTGGAGG 2640 CCAGAAAGAA AAGCCTTCTT TTTCACTAGG CCAGGACTAC ATTGAGAGAT GAAGAATGGA 2700 GGTTGTTTCC AAAAGAAATA AAGAGAAACT TAGAAGTTGT CTCTGG 2746 Seq ID NO : 52 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 641.. 2299 1 11 21 31 41 51 1 1 1 1 1 1 GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60 GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120 GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180 CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGCCCTCGTG CTCCTCCCGG 240 GGTGCTTGGC ACAGCCTCGG ATTCCTCCCT CTCGCTGCTC GAGTCAGTTT CCCTATCGGC 300 GGCAGCGGGC AAGGCGGCGG CGGCGGCGGC GGCAGCCGCG GTGGCGGCGT GGGGAACATC 360 TCGGCAGCCA CCGCGCTTCT CCCGCTGGAG CGGGCGTCCA GCTTGGCTGC CCTCGGTCCT 420 TCCCTGCCAC GTTTCGGGTC GCCCTGCACC CCCCACCCAG GCTCGCTTCT CTTCGAAGCG 480 GGAAGGGCGC CTTGCAGGAT CCTGCCGCCC CTCCAACCGG ATCCTGGGTC TAGAGCTCCC 540 CAGAGCGAGG CGCTCGCCAG GACTCCTGCC CCGCCAACCC TGACCGCCGG GGGGTGCCCC 600 CGGGACGTAG CGCCGCGGAG AGGAAGCGGC AAAGGGGACC ATGCGGCGCC TGACTCGTCG 660 GCTGGTTCTG CCAGTCTTCG GGGTGCTCTG GATCACGGTG CTGCTGTTCT TCTGGGTAAC 720 CAAGAGGAAG TTGGAGGTGC CGACGGGACC TGAAGTGCAG ACCCCTAAGC CTTCGGACGC 780 TGACTGGGAC GACCTGTGGG ACCAGTTTGA TGAGCGGCGG TATCTGAATG CCAAAAAGTG 840 GCGCGTTGGT GACGACCCCT ATAAGCTGTA TGCTTTCAAC CAGCGGGAGA GTGAGCGGAT 900 CTCCAGCAAT CGGGCCATCC CGGACACTCG CCATCTGAGA TGCACACTGC TGGTGTATTG 960 CACGGACCTT CCACCCACTA GCATCATCAT CACCTTCCAC AACGAGGCCC GCTCCACGCT 1020 GCTCAGGACC ATCCGCAGTG TATTAAACCG CACCCCTACG CATCTGATCC GGGAAATCAT 1080 ATTAGTGGAT GACTTCAGCA ATGACCCTGA TGACTGTAAA CAGCTCATCA AATTGCCCAA 1140 GGTGAAATGC TTGCGCAATA ATGAACGGCA AGGTCTGGTC CGGTCCCGGA TTCGGGGCGC 1200 TGACATCGCC CAGGGCACCA CTCTGACTTT CCTCGACAGC CACTGTGAGG TGAACAGGGA 1260 CTGGCTCCAG CCTCTGTTGC ACAGGGTCAA AGAGGACTAC ACGCGGGTGG TGTGCCCTGT 1320 GATCGATATC ATTAACCTGG ACACCTTCAC CTACATCGAG TCTGCCTCGG AGCTCAGAGG 1380 GGGGTTTGAC TGGAGCCTCC ACTTCCAGTG GGAGCAGCTC TCCCCAGAGC AGAAGGCTCG 1440 GCGCCTGGAC CCCACGGAGC CCATCAGGAC TCCTATCATA GCTGGAGGGC TCTTCGTGAT 1500 CGACAAAGCT TGGTTTGATT ACCTGGGGAA ATATGATATG GACATGGACA TCTGGGGTGG 1560 GGAGAACTTT GAAATCTCCT TCCGAGTGTG GATGTGCGGG GGCAGCCTAG AGATCGTCCC 1620 CTGCAGCCGA GTGGGGCACG TCTTCCGGAA GAAGCACCCC TACGTTTTCC CTGATGGAAA 1680 TGCCAACACG TATATAAAGA ACACCAAGCG GACAGCTGAA GTGTGGATGG ATGAATACAA 1740 GCAATACTAT TACGCTGCCC GGCCATTCGC CCTGGAGAGG CCCTTCGGGA ATGTTGAGAG 1800 CAGATTGGAC CTGAGGAAGA ATCTGCGCTG CCAGAGCTTC AAGTGGTACC TGGAGAATAT 1860 CTACCCTGAA CTCAGCATCC CCAAGGAGTC CTCCATCCAG AAGGGCAATA TCCGACAGAG 1920 ACAGAAGTGC CTGGAATCTC AAAGGCAGAA CAACCAAGAA ACCCCAAACC TAAAGTTGAG 1980 CCCCTGTGCC AAGGTCAAAG GCGAAGATGC AAAGTCCCAG GTATGGGCCT TCACATACAC 2040 CCAGCAGATC CTCCAGGAGG AGCTGTGCCT GTCAGTCATC ACCTTGTTCC CTGGCGCCCC 2100 AGTGGTTCTT GTCCTTTGCA AGAATGGAGA TGACCGACAG CAATGGACCA AAACTGGTTC 2160 CCACATCGAG CACATAGCAT CCCACCTCTG CCTCGATACA GATATGTTCG GTGATGGCAC 2220 CGAGAACGGC AAGGAAATCG TCGTCAACCC ATGTGAGTCC TCACTCATGA GCCAGCACTG 2280 GGACATGGTG AGCTCTTGAG GACCCCTGCC AGAAGCAGCA AGGGCCATGG GGTGGTGCTT 2340

CCCTGGACCA GAACAGACTG GAAACTGGGC AGCAAGCAGC CTGCAACCAC CTCAGACATC 2400 CTGGACTGGG AGGTGGAGGC AGAGCCCCCC AGGACAGGAG CAACTGTCTC AGGGAGGACA 2460 GAGGAAAACA TCACAAGCCA ATGGGGCTCA AAGACAAATC CCACATGTTC TCAAGGCCGT 2520 TAAGTTCCAG TCCTGGCCAG TCATTCCCTG ATTGGTATCT GGAGACAGAA ACCTAATGGG 2580 AAGTGTTTAT TGTTCCTTTT CCTACAAAGG AAGCAGTCTC TGGAGGCCAG AAAGAAAAGC 2640 CTTCTTTTTC ACTAGGCCAG GACTACATTG AGAGATGAAG AATGGAGGTT GTTTCCAAAA 2700 GAAATAAAGA GAAACTTAGA AGTTGAAAAA AAAAAAAAAA A 2741 Seq ID NO : 53 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 400.. 1959 1 11 21 31 41 51 GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60 GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120 GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180 CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGCCCTTCTC TTCGAAGCGG 240 GAAGGGCGCC TTGCAGGATC CTGCCGCCCC TCCAACCGGA TCCTGGGTCT AGAGCTCCCC 300 AGAGCGAGGC GCTCGCCAGG ACTCCTGCCC CGCCAACCCT GACCGCCGGG GGGTGCCCCC 360 GGGACGTAGC GCCGCGGAGA GGAAGCGGCA AAGGGGACCA TGCGGCGCCT GACTCGTCGG 420 CTGGTTCTGC CAGTCTTCGG GGTGCTCTGG ATCACGGTGC TGCTGTTCTT CTGGGTAACC 480 AAGAGGAAGT TGGAGGTGCC GACGGGACCT GAAGTGCAGA CCCCTAAGCC TTCGGACGCt 540 GACTGGGACG ACCTGTGGGA CCAGTTTGAT GAGCGGCGGT ATCTGAATGC CAAAAAGTGG 600 CGCGTTGGTG ACGACCCCTA TAAGCTGTAT GCTTTCAACC AGCGGGAGAG TGAGCGGATC 660 TCCAGCAATC GGGCCATCCC GGACACTCGC CATCTGAGTG TATTAAACCG CACCCCTACG 720 CATCTGATCC GGGAAATCAT ATTAGTGGAT GACTTCAGCA ATGACCCTGA TGACTGTAAA 780 CAGCTCATCA AgTTGCCCAA GGTGAAATGC TTGCGCAATA ATGAACGGCA AGGTCTGGTC 840 CGGTCCCGGA TTCGGGGCGC TGACATCGCC CAGGGCACCA CTCTGACTTT CCTCGACAGC 900 CACTGTGAGG TGAACAGGGA CTGGCTCCAG CCTCTGTTGC ACAGGGTCAA AGAGGACTAC 960 ACGCGGGTGG TGTGCCCTGT GATCGATATC ATTAACCTGG ACACCTTCAC CTACATCGAG 1020 TCTGCCTCGG AGCTCAGAGG GGGGTTTGAC TGGAGCCTCC ACTTCCAGTG GGAGCAGCTC 1080 TCCCCAGAGC AGAAGGCTCG GCGCCTGGAC CCCACGGAGC CCATCAGGAC TCCTATCATA 1140 GCTGGAGGGC TCTTCGTGAT CGACAAAGCT TGGTTTGATT ACCTGGGGAA ATATGATATG 1200 GACATGGACA TCTGGGGTGG GGAGAACTTT GAAATCTCCT TCCGAGTGTG GATGTGCGGG 1260 GGCAGCCTAG AGATCGTCCC CTGCAGCCGA GTGGGGCACG TCTTCCGGAA GAAGCACCCC 1320 TACGTTTTCC CTGATGGAAA TGCCAACACG TATATAAAGA ACACCAAGCG GACAGCTGAA 1380 GTGTGGATGG ATGAATACAA GCGATACTAT TACGCTGCCC GGCCATTCGC CCTGGAGAGG 1440 CCCTTCGGGA ATGTTGAGAG CAGATTGGAC CTGAGGAAGA ATCTGCGCTG CCAGAGCTTC 1500 AAGTGGTACC TGGAGAATAT CTACCCTGAA CTCAGCATCC CCAAGGAGTC CTCCATCCAG 1560 AAGGGCAATA TCCGACAGAG ACAGAAGTGC CTGGAATCTC AAAGGCAGAA CAACCAAGAA 1620 ACCCCAAACC TAAAGTTGAG CCCCTGTGCC AAGGTCAAAG GCGAAGATGC AAAGTCCCAG 1680 GTATGGGCCT TCACATACAC CCAGCAGATC CTCCAGGAGG AGCTGTGCCT GTCAGTCATC 1740 ACCTTGTTCC CTGGCGCCCC AGTGGTTCTT GTCCTTTGCA AGAATGGAGA TGACCGACAG 1800 CAATGGACCA AAACTGGTTC CCACATCGAG CACATAGCAT CCCACCTCTG CCTCGATACA 1860 GATATGTTCG GTGATGGCAC CGAGAACGGC AAGGAAATCG TCGTCAACCC ATGTGAGTCC 1920 TCACTCATGA GCCAGCACTG GGACATGGTG AGCTCTTGAG GACCCCTGCC AGAAGCAGCA 1980 AGGGCCATGG GGTGGTGCTT CCCTGGACCA GAACAGACTG GAAACTGGGC AGCAAGCAGC 2040 CTGCAACCAC CTCAGACATC CTGGACTGGG AGGTGGAGGC AGAGCCCCCC AGGACAGGAG 2100 CAACTGTCTC AGGGAGGACA GAGGAAAACA TCACAAGCCA ATGGGGCTCA AAGACAAATC 2160 CCACATGTTC TCAAGGCCGT TAAGTTCCAG TCCTGGCCAG TCATTCCCTG ATTGGTATCT 2220 GGAGACAGAA ACCTAATGGG AAGTGTTTAT TGTTCCTTTT CCTACAAAGG AAGCAGTCTC 2280 TGGAGGCCAG AAAGAAAAGC CTTCTTTTTC ACTAGGCCAG GACTACATTG AGAGATGAAG 2340 AATGGAGGTT GTTTCCAAAA GAAATAAAGA GAAACTTAGA AGTTG 2385 Seq ID NO : 54 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 1241.. 2377 1 11 21 31 41 51 GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60 GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120 GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180 CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGcCCTCGTG CTCCTCCCGG 240 GGTGCTTGGC ACAGCCTCGG ATTCCTCCCT CTCGCTGCTC GAGTCAGTTT CCCTATCGGC 300 GGCAGCGGGC AAGGCGGCGG CGGCGGCGGC GGCAGCCGCG GTGGCGGCGT GGGGAACATC 360 TCGGCAGCCA CCGCGCTTCT CCCGCTGGAG CGGGCGTCCA GCTTGGCTGC CCTCGGTCCT 420 TCCCTGCCAC GTTTCGGGTC GCCCTGCACC CCCCACCCAG GCTCGCTTCT CTTCGAAGCG 480 GGAAGGGCGC CTTGCAGGAT CCTGCCGCCC CTCCAACCGG ATCCTGGGTC TAGAGCTCCC 540 CAGAGCGAGG CGCTCGCCAG GACTCCTGCC CCGCCAACCC TGACCGCCGG GGGGTGCCCC 600 CGGGACGTAG CGCCGCGGAG AGGAAGCGGC AAAGGGGACC ATGCGGCGCC TGACTCGTCG 660 GCTGGTTCTG CCAGTCTTCG GGGTGCTCTG GATCACGTGC TGCTGTTCTT CTGGGTAACC 720 AAGAGGAAGT GGAGGTGCCG ACGGGACCTG AAGTGCAGAC CCCTAAGGGT TCTTCCCAAA 780 GTTAGTGCAG CCTACACCCA GGATTGAACA AAGACAGCTT GGAAGTTAGA AGCAAGATGG 840 AGTCTGTTAG CCTTCGGACG CTGACTGGGA CGACCTGTGG GACCAGTTTG ATGAGCGGCG 900 GTATCTGAAT GCCAAAAAGT GGCGCGTTGG TGACGACCCC TATAAGCTGT ATGCTTTCAA 960 CCAGCGGGAG AGTGAGCGGA TCTCCAGCAA TCGGGCCATC CCGGACACTC GCCATCTGAG 1020 ATGCACACTG CTGGTGTATT GCACGGACCT TCCACCCACT AGCATCATCA TCACCTTCCA 1080 CAACGAGGCC CGCTCCACGC TGCTCAGGAC CATCCGCAGT GTATTAAACC GCACCCCTAC 1140 GCATCTGATC CGGGAAATCA TATTAGTGGA TGACTTCAGC AATGACCCTG ATGACTGTAA 1200 ACAGCTCATC AAgTTGCCCA AGGTGAAATG CTTGCGCATA ATGAACGGCA AGGTCTGGTC 1260 CGGTCCCGGA TTCGGGGCGC TGACATCGCC CAGGGCACAC TCTGACTTTC TCGACAGCCA 1320 CTGTGAGGTG AACAGGGACT GGCTCCAGCC TCTGTTGCAC AGGGTCAAAG AGGACTACAC 1380 GCGGGTGGTG TGCCCTGTGA TCGATATCAT TAACCTGGAC ACCTTCACCT ACATCGAGTC 1440 TGCCTCGGAG CTCAGAGGGG GGTTTGACTG GAGCCTCCAC TTCCAGTGGG AGCAGCTCTC 1500

CCCAGAGCAG AAGGCTCGGC GCCTGGACCC CACGGAGCCC ATCAGGACTC CTATCATAGC 1560 TGGAGGGCTC TTCGTGATCG ACAAAGCTTG GTTTGATTAC CTGGGGAAAT ATGATATGGA 1620 CATGGACATC TGGGGTGGGG AGAACTTTGA AATCTCCTTC CGAGTGTGGA TGTGCGGGGG 1680 CAGCCTAGAG ATCGTCCCCT GCAGCCGAGT GGGGCACGTC TTCCGGAAGA AGCACCCCTA 1740 CGTTTTCCCT GATGGAAATG CCAACACGTA TATAAAGAAC ACCAAGCGGA CAGCTGAAGT 1800 GTGGATGGAT GAATACAAGC AATACTATTA CGCTGCCCGG CCATTCGCCC TGGAGAGGCC 1860 CTTCGGGAAT GTTGAGAGCA GATTGGACCT GAGGAAGAAT CTGCGCTGCC AGAGCTTCAA 1920 GTGGTACCTG GAGAATATCT ACCCTGAACT CAGCATCCCC AAGGAGTCCT CCATCCAGAA 1980 GGGCAATATC CGACAGAGAC AGAAGTGCCT GGAATCTCAA AGGCAGAACA ACCAAGAAAC 2040 CCCAAACCTA AAGTTGAGCC CCTGTGCCAA GGTCAAAGGC GAAGATGCAA AGTCCCAGGT 2100 ATGGGCCTTC ACATACACCC AGCAGATCCT CCAGGAGGAG CTGTGCCTGT CAGTCATCAC 2160 CTTGTTCCCT GGCGCCCCAG TGGTTCTTGT CCTTTGCAAG AATGGAGATG ACCGACAGCA 2220 ATGGACCAAA ACTGGTTCCC ACATCGAGCA CATAGCATCC CACCTCTGCC TCGATACAGA 2280 TATGTTCGGT GATGGCACCG AGAACGGCAA GGAAATCGTC GTCAACCCAT GTGAGTCCTC 2340 ACTCATGAGC CAGCACTGGG ACATGGTGAG CTCTTGAGGA CCCCTGCCAG AAGCAGCAAG 2400 GGCCATGGGG TGGTGCTTCC CTGGACCAGA ACAGACTGGA AACTGGGCAG CAAGCAGCCT 2460 GCAACCACCT CAGACATCCT GGACTGGGAG GTGGAGGCAG AGCCCCCCAG GACAGGAGCA 2520 ACTGTCTCAG GGAGGACAGA GGAAAACATC ACAAGCCAAT GGGGCTCAAA GACAAATCCC 2580 ACATGTTCTC AAGGCCGTTA AGTTCCAGTC CTGGCCAGTC ATTCCCTGAT TGGTATCTGG 2640 AGACAGAAAC CTAATGGGAA GTGTTTATTG TTCCTTTTCC TACAAAGGAA GCAGTCTCTG 2700 GAGGCCAGAA AGAAAAGCCT TCTTTTTCAC TAGGCCAGGA CTACATTGAG AGATGAAGAA 2760 TGGAGGTTGT TTCCAAAAGA AATAAAGAGA AACTTAGAAG TTG 2803 Seq ID NO : 55 DNA Sequence Nucleic Acid Accession # : NM001218 Coding sequence ; 1.. 1080 1 11 21 31 41 51 1 1 1 1 1 1 GTACTCGCCA CGGCACCCAG GCTGCGCGCA CGCGGTCCCG GTGTGCAGCT GGAGAGCGAG 60 CGGCCACCGG GAGCCCCCGG CACAGCCCGC GCCCGCCCCG CAGGAGCCCG CGAAGATGCC 120 CCGGCGCAGC CTGCACGCGG CGGCCGTGCT CCTGCTGGTG ATCTTAAAGG AACAGCCTTC 180 CAGCCCGGCC CCAGTGAACG GTTCCAAGTG GACTTATTTT GGTCCTGATG GGGAGAATAG 240 CTGGTCCAAG AAGTACCCGT CGTGTGGGGG CCTGCTGCAG TCCCCCATAG ACCTGCACAG 300 TGACATCCTC CAGTATGACG CCAGCCTCAC GCCCCTCGAG TTCCAAGGCT ACAATCTGTC 360 TGCCAACAAG CAGTTTCTCC TGACCAACAA TGGCCATTCA GTGAAGCTGA ACCTGCCCTC 420 GGACATGCAC ATCCAGGGCC TCCAGTCTCG CTACAGTGCC ACGCAGCTGC ACCTGCACTG 480 GGGGAACCCG AATGACCCGC ACGGCTCTGA GCACACCGTC AGCGGACAGC ACTTCGCCGC 540 CGAGCTGCAC ATTGTCCATT ATAACTCAGA CCTTTATCCT GACGCCAGCA CTGCCAGCAA 600 CAAGTCAGAA GGCCTCGCTG TCCTGGCTGT TCTCATTGAG ATGGGCTCCT TCAATCCGTC 660 CTATGACAAG ATCTTCAGTC ACCTTCAACA TGTAAAGTAC AAAGGCCAGG AAGCATTCGT 720 CCCGGGATTC AACATTGAAG AGCTGCTTCC GGAGAGGACC GCTGAATATT ACCGCTACCG 780 GGGGTCCCTG ACCACACCCC CTTGCAACCC CACTGTGCTC TGGACAGTTT TCCGAAACCC 840 CGTGCAAATT TCCCAGGAGC AGCTGCTGGC TTTGGAGACA GCCCTGTACT GCACACACAT 900 GGACGACCCT TCCCCCAGAG AAATGATCAA CAACTTCCGG CAGGTCCAGA AGTTCGATGA 960 GAGGCTGGTA TACACCTCCT TCTCCCAAGT GCAAGTCTGT ACTGCGGCAG GACTGAGTCT 1020 GGGCATCATC CTCTCACTGG CCCTGGCTGG CATTCTTGGC ATCTGTATTG TGGTGGTGGT 1080 GTCCATTTGG CTTTTCAGAA GGAAGAGTAT CAAAAAAGGT GATAACAAGG GAGTCATTTA 1140 CAAGCCAGCC ACCAAGATGG AGACTGAGGC CCACGCTTGA GGTCCCCGGA GCTCCCGGGC 1200 ACATCCAGGA AGGACCTTGC TTTGGACCCT ACACACTTCG GCTCTCTGGA CACTTGCGAC 1260 ACCTCAAGGT GTTCTCTGTA GCTCAATCTG CAAACATGCC AGGCCTCAGG GATCCTCTGC 1320 TGGGTGCCTC CTTGCCTTGG GACCATGGCC ACCCCAGAGC CATCCGATCG ATGGATGGGA 1380 TGCACTCTCA GACCAAGCAG CAGGAATTCA AAGCTGCTTG CTGTAACTGT GTGAGATTGT 1440 GAAGTGGTCT GAATTCTGGA ATCACAAACC AAGCCATGCT GGTGGGCCAT TAATGGTTGG 1500 AAAACACTTT CATCCGGGGC TTTGCCAGAG CGTGCTTTCA AGTGTCCTGG AAAGTCTGCT 1560 GCTTCTCCAA GCTTTCAGAC AAGAATGTGC ACTCTCTGCT TAGGTTTTGC TTGGGAAACT 1620 CAACTTCTTT CCTCTGGAGA CGGGGCATCT CCCTCTGATT TCCTTCTGCT ATGACAAAAC 1680 CTTTAATCTG CACCTTACAA CTCGGGGACA AATGGGGACA GGAAGGATCA AGTTGTAGAG 1740 AGAAAAAAGA AAACAAGAGA TATACATTGT GATATATTAG GGACACTTTC ACAGTCCTGT 1800 CCTCTGGATC ACAGACACTG CACAGACCTT AGGGAATGGC AGGTTCAAGT TCCACTTCTT 1860 GGTGGGGATG AGAAGGGAGA GAGAGCTAGA GGGACAAAGA GAATGAGAAG ACATGGATGA 1920 TCTGGGAGAG TCTCACTTTG GAATCAGAAT TGGAATCACA TTCTGTTTAT CAAGCCATAA 1980 TGTAAGGACA GAATAATACA ATATTAAGTC CAAATCCAAC CTCCTGTCAG TGGAGCAGTT 2040 ATGTTTTATA CTCTACAGAT TTTACAAATA ATGAGGCTGT TCCTTGAAAA TGTGTTGTTG 2100 CTGTGTCCTG GAGGAGACAT GAGTTCCGAG ATGACCCAAT CTGCCTTTGA ATCTGGAGGA 2160 AATAGGCAGA AACAAAATGA CTGTAGAACT TATTCTCTGT AGGCCAAATT TCATTTCAGC 2220 CACTTCTGCA GGATCCCTAC TGCCAACCTG GAATGGAGAC TTTTATCTAC TTCTCTCTCT 2280 CTGAAGATGT CAAATCGTGG TTTAGATCAA ATATATTTCA AGCTATAAAA GCAGGAGGTT 2340 ATCTGTGCAG GGGGCTGGCA TCATGTATTT AGGGGCAAGT AATAATGGAA TGCTACTAAG 2400 ATACTCCATA TTCTTCCCCG AATCACACAG ACAGTTTCTG ACAGGCGCAA CTCCTCCATT 2460 TTCCTCCCGC AGGTGAGAAC CCTGTGGAGA TGAGTCAGTG CCATGACTGA GAAGGAACCG 2520 ACCCCTAGTT GAGAGCACCT TGCAGTTCCC CGAGAACTTT CTGATTCACA GTCTCATTTT 2580 GACAGCATGA AATGTCCTCT TGAAGCATAG CTTTTTAAAT ATCTTTTTCC TTCTACTCCT 2640 CCCTCTGACT CTAAGAATTC TCTCTTCTGG AATCGCTTGA ACCCAGGAGG CGGAGGTTGC 2700 AGTAAGCCAA GGTCATGCCA CTGCACTCTA GCCTGGGTGA CAGAGCGAGA CTCCATCTCA 2760 AAAAAAAAAA AAAAA 2775 Seq ID NO : 56 DNA Sequence Nucleic Acid Accession # : BC000278 Coding sequence : 113.. 1144 1 11 21 31 41 51 CTCGCCACGG CACCCAGGCT GCGCGCACGC GGTCCCGGTG TGCAGCTGGA GAGCGAGCGG 60 CCACCGGGAG CCCCCGGCAC AGCCCGCGCC CGCCCCGCAG GAGCCCGCGA AGATGCCCCG 120 GCGCAGCCTG CACGCGGCGG CCGTGCTCCT GCTGGTGATC TTAAAGGAAC AGCCTTCCAG 180

CCCGGCCCCA GTGAACGGTT CCAAGTGGAC TTATTTTGGT CCTGATGGGG AGAATAGCTG 240 GTCCAAGAAG TACCCGTCGT GTGGGGGCCT GCTGCAGTCC CCCATAGACC TGCACAGTGA 300 CATCCTCCAG TATGACGCCA GCCTCACGCC CCTCGAGTTC CAAGGCTACA ATCTGTCTGC 360 CAACAAGCAG TTTCTCCTGA CCAACAATGG CCATTCAGTG AAGCTGAACC TGCCCTCGGA 420 CATGCACATC CAGGGCCTCC AGTCTCGCTA CAGTGCCACG CAGCTGCACC TGCACTGGGG 480 GAACCCGAAT GACCCGCACG GCTCTGAGCA CACCGTCAGC GGACAGCACT TCGCCGCCGA 540 GCTGCACATT GTCCATTATA ACTCAGACCT TTATCCTGAC GCCAGCACTG CCAGCAACAA 600 GTCAGAAGGC CTCGCTGTCC TGGCTGTTCT CATTGAGATG GGCTCCTTCA ATCCGTCCTA 660 TGACAAGATC TTCAGTCACC TTCAACATGT AAAGTACAAA GGCCAGGAAG CATTCGTCCC 720 GGGATTCAAC ATTGAAGAGC TGCTTCCGGA GAGGACCGCT GAATATTACC GCTACCGGGG 780 GTCCCTGACC ACACCCCCTT GCAACCCCAC TGTGCTCTGG ACAGTTTTCC GAAACCCCGT 840 GCAAATTTCC CAGGAGCAGC TGCTGGCTTT GGAGACAGCC CTGTACTGCA CACACATGGA 900 CGACCCTTCC CCCAGAGAAA TGATCAACAA CTTCCGGCAG GTCCAGAAGT TCGATGAGAG 960 GCTGGTATAC ACCTCCTTCT CCCAAGGCAT CATCCTCTCA CTGGCCCTGG CTGGCATTCT 1020 TGGCATCTGT ATTGTGGTGG TGGTGTCCAT TTGGCTTTTC AGAAGGAAGA GTATCAAAAA 1080 AGGTGATAAC AAGGGAGTCA TTTACAAGCC AGCCACCAAG ATGGAGACTG AGGCCCACGC 1140 TTGAGGTCCC CGGAGCTCCC GGGCACATCC AGGAAGGACC TTGCTTTGGA CCCTACACAC 1200 TTCGGCTCTC TGGACACTTG CGACACCTCA AGGTGTTCTC TGTAGCTCAA TCTGCAAACA 1260 TGCCAGGCCT CAGGGATCCT CTGCTGGGTG CCTCCTTGCC TTGGGACCAT GGCCACCCCA 1320 GAGCCATCCG ATCGATGGAT GGGATGCACT CTCAGACCAA GCAGCAGGAA TTCAAAGCTG 1380 CTTGCTGTAA CTGTGTGAGA TTGTGAAGTG GTCTGAATTC TGGAATCACA AACCAAGCCA 1440 TGCTGGTGGG CCATTAATGG TTGGAAAACA CTTTCATCCG GGGCTTTGCC AGAGCGTGCT 1500 TTCAAGTGTC CTGGAAAGTC TGCTGCTTCT CCAAGCTTTC AGACAAGAAT GTGCACTCTC 1560 TGCTTAGGTT TTGCTTGGGA AACTCAACTT CTTTCCTCTG GAGACGGGGC ATCTCCCTCT 1620 GATTTCCTTC TGCTATGACA AAACCTTTAA TCTGCACCTT ACAACTCGGG GACAAATGGG 1680 GACAGGAAGG ATCAAGTTGT AAAAAAAAAA AAAAAAAA 1718 Seq ID NO : 57 DNA Sequence Nucleic Acid Accession # : NM 006632. 1 Coding sequence : 377.. 1582 1 11 21 31 41 51 ACGCGTCCGC CCACGCGTCC GCCCACGCGT CCGGTCGGGG CCAGAGCGCA GGTGTACCTG 60 GCGGCCGTGC TGGAGCACCT GACCGCCGAG ATCCTGGAGC TGGCTGGCAA CCCGGCCCGC 120 GACAAGAAGA CCCGCATCAT CCTGCGCCAC CTGTAGCTGG CCATTCGCAA CGGCGAGGAG 180 CTTAACAAGC TGCTGGGCGA AGTCACCATC GCGCAGGGCG GTGTCCTGCC CAACATTCAG 240 GGCGTGCTTC TGCCCCAGAA GACCAAGAGC CACCACAAGG CCAAGGGTGA AAACCATTCA 300 CTAGGAGAGG AGAAACACAA TGGCCACCAA GACAGAGTTG AGTCCCACAG CAAGGGAGAG 360 CAAGAACGCA CAAGATATGC AAGTGGATGA GACACTGATC CCCAGGAAAG GTCCAAGTTT 420 ATGTTCTGCT CGCTATGGAA TAGCCCTCGT CTTACATTTC TGCAATTTCA CAACGATAGC 480 ACAAAATGTC ATCATGAACA TCACCATGGT AGCCATGGTC AACAGCACAA GCCCTCAATC 540 CCAGCTCAAT GATTCCTCTG AGGTGCTGCC TGTTGACTCA TTTGGTGGCC TAAGTAAAGC 600 CCCAAAGAGT CTTCCTGCAA AGTCCTCAAT ACTTGGGGGT CAGTTTGCAA TTTGGGAAAA 660 GTGGGGCCCT CCACAAGAAC GAAGCAGACT CTGCAGCATT GCTTTATCAG GAATGTTACT 720 GGGATGCTTT ACTGCCATCC TCATAGGTGG CTTCATTAGT GAAACCCTTG GGTGGCCCTT 780 TGTCTTCTAT ATCTTTGGAG GTGTTGGCTG TGTCTGCTGC CTTCTCTGGT TTGTTGTGAT 840 TTATGATGAC CCCTTTTCCT ATCCATGGAT AAGCACCTCA GAAAAAGAAT ACATCATATC 900 CTCCTTGAAA CAACAGGTCG GGTCTTCTAA GCAGCCTCTT CCCATCAAAG CTATGCTCAG 960 ATCTCTACCC ATTTGGTCCA TATGTTTAGG CTGTTTCAGC CATCAATGGT TAGTTAGCAC 1020 AATGGTTGTA TACATACCAA CTTACATCAG CTCTGTGTAC CATGTTAACA TCAGAGACAA 1080 TGGACTTCTA TCTGCCCTTC CTTTTATTGT TGCCTGGGTC ATAGGCATGG TGGGAGGCTA 1140 TCTGGCAGAT TTCCTTCTAA CCAAAAAGTT TAGACTCATC ACTGTGAGGA AAATTGCCAC 1200 AATTTTAGGA AGTCTCCCCT CTTCAGCACT CATTGTGTCT CTGCCTTACC TCAATTCCGG 1260 CTATATCACA GCAACTGCCT TGCTGACGCT CTCTTGCGGA TTAAGCACAT TGTGTCAGTC 1320 AGGGATTTAT ATCAATGTCT TAGATATTGC TCCAAGGTAT TCCAGTTTTC TCATGGGAGC 1380 ATCAAGAGGA TTTTCGAGCA TAGCACCTGT CATTGTACCC ACTGTCAGCG GATTTCTTCT 1440 TAGTCAGGAC CCTGAGTTTG GGTGGAGGAA TGTCTTCTTC TTGCTGTTTG CCGTTAACCT 1500 GTTAGGACTA CTCTTCTACC TCATATTTGG AGAAGCAGAT GTCCAAGAAT GGGCTAAAGA 1560 GAGAAAACTC ACTCGTTTAT GAAGTTATCC CACCTTGGAT GGAAAAGTCA TTAGGCACCG 1620 TATTGCATAA AATAGAAGGC TTCCGTGATG AAAATACCAG TGAAAAGATT TTTTTTTCCT 1680 GTGGCTCTTT TCAATTATGA GATCAGTTCA TTATTTTATT CAGACTTTTT TTTGAGAGAA 1740 ATGTAAGATG AATAAAAATT CAAATAAAAT GATAACTAAG AAAAAAAAAA AAAAA 1795 Seq ID NO : 58 DNA Sequence Nucleic Acid Accession # : Nom 003058. 1 Coding sequence : 145.. 1812 1 11 21 31 41 51 1 1 1 1 1 1 GGCCCTGCCC TGAAGGCTGG TCACTTGCAG AGGTAAACTC CCCTCTTTGA CTTCTGGCCA 60 GGGTTTGTGC TGAGCTGGCT GCAGCCGCTC TCAGCCTCGC TCCGGGCACG TCGGGCAGCC 120 TCGGGCCCTC CTGCCTGCAG GATCATGCCC ACCACCGTGG ACGATGTCCT GGAGCATGGA 180 GGGGAGTTTC ACTTTTTCCA GAAGCAAATG TTTTTCCTCT TGGCTCTGCT CTCGGCTACC 240 TTCGCGCCCA TCTACGTGGG CATCGTCTTC CTGGGCTTCA CCCCTGACCA CCGCTGCCGG 300 AGCCCCGGAG TGGCCGAGCT GAGTCTGCGC TGCGGCTGGA GTCCTGCAGA GGAACTGAAC 360 TACACGGTGC CGGGCCCAGG ACCTGCGGGC GAAGCCTCCC CAAGACAGTG TAGGCGCTAC 420 GAGGTGGACT GGAACCAGAG CACCTTTGAC TGCGTGGACC CCCTGGCCAG CCTGGACACC 480 AACAGGAGCC GCCTGCCACT GGGCCCCTGC CGGGACGGCT GGGTGTACGA GACGCCTGGC 540 TCGTCCATCG TCACCGAGTT TAACCTGGTA TGTGCCAACT CCTGGATGTT GGACCTATTC 600 CAGTCATCAG TGAATGTAGG ATTCTTTATT GGCTCTATGA GTATCGGCTA CATAGCAGAC 660 AGGTTTGGCC GTAAGCTCTG CCTCCTAACT ACAGTCCTCA TAAATGCTGC AGCTGGAGTT 720 CTCATGGCCA TTTCCCCAAC CTATACGTGG ATGTTAATTT TTCGCTTAAT CCAAGGACTG 780 GTCAGCAAAG CAGGCTGGTT AATAGGCTAC ATCCTGATTA CAGAATTTGT TGGGCGGAGA 840 TATCGGAGAA CAGTGGGGAT TTTTTACCAA GTTGCCTATA CAGTTGGGCT CCTGGTGCTA 900 GCTGGGGTGG CTTACGCACT TCCTCACTGG AGGTGGTTGC AGTTCACAGT TGCTCTGCCC 960

AACTTCTTCT TCTTGCTCTA TTACTGGTGC ATACCTGAGT CTCCCAGGTG GCTGATCTCC 1020 CAGAATAAGA ATGCTGAAGC CATGAGAATC ATTAAGCACA TCGCAAAGAA AAATGGAAAA 1080 TCTCTACCCG CCTCCCTTCA GCGCCTGAGA CTTGAAGAGG AAACTGGCAA GAAATTGAAC 1140 CCTTCATTTC TTGACTTGGT CAGAACTCCT CAGATAAGGA AACATACTAT GATATTGATG 1200 TACAACTGGT TCACGAGCTC TGTGCTCTAC CAGGGCCTCA TCATGCACAT GGGCCTTGCA 1260 GGTGACAATA TCTACCTGGA TTTCTTCTAC TCTGCCCTGG TTGAATTCCC AGCTGCCTTC 1320 ATGATCATCC TCACCATCGA CCGCATCGGA CGCCGTTACC CTTGGGCTGC ATCAAATATG 1380 GTTGCAGGGG CAGCCTGTCT GGCCTCAGTT TTTATACCTG GTGATCTACA ATGGCTAAAA 1440 ATTATTATCT CATGCTTGGG AAGAATGGGG ATCACAATGG CCTATGAGAT AGTCTGCCTG 1500 GTCAATGCTG AGCTGTACCC CACATTCATT AGGAATCTTG GCGTCCACAT CTGTTCCTCA 1560 ATGTGTGACA TTGGTGGCAT CATCACGCCA TTCCTGGTCT ACCGGCTCAC TAACATCTGG 1620 CTTGAGCTCC CGCTGATGGT TTTCGGCGTA CTTGGCTTGG TTGCTGGAGG TCTGGTGCTG 1680 TTGCTTCCAG AAACTAAAGG GAAAGCTTTG CCTGAGACCA TCGAGGAAGC CGAAAATATG 1740 CAAAGACCAA GAAAAAATAA AGAAAAGATG ATTTACCTCC AAGTTCAGAA ACTAGACATT 1800 CCATTGAACT AAGAAGAGAG ACCGTTGCTG CTGTCATGAC CTAGCTTTGA TGGCAGCAAG 1860 ACCAAAAGTA GAAATCCCTG CACTCATCAC AAAGCCCATA CAACTCAACC AAACTTACCC 1920 CTGAGCCCTA TCAACCTAGG TCTACAGCCA GTGGAGTCTA TTGTACACTG TGGAAAAATA 1980 CCCATGGGAC CAGATCCTGC CAAATTCTTC CAGCTCACTT TATTCTCAGC ATTCCTAGGA 2040 CATTGGACAT TGGTTTTCTG GAGGGTTTTT TTTCCGATCT TTGTATTTTT TTAAATTTGA 2100 TTCTTTTCTT TGCAATGCTA GCAACCAGAA TACATAGGGG AACTGTGGGC TAGGCAAANA 2160 AAATAGAAAA AGTGTGAAAA ACAGTAAAGT TGGGAGAGGA GCATCTATTT TCTTAAAGAA 2220 ATAAAACACC NAAAACAAAA AAAAAAAAAA AAAAAAA 2257 Seq ID NO : 59 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 227.. 2311 1 11 21 31 41 51 GTCAGGGGCG TGTTGGCCCC GCACAGATTG AGCCGAGTTG TCGCCCCGCT GGGAGAAGTG 60 ACCCTCCTGC GCCTGATCAG AACACTGAGG CTCAGAGAAG TTAACTACTC CAAAGTCATA 120 TAGCCAGTAT TTTCTGGAGC TGTAATTCAA ATCAGATGTG TTCAATACCT TCTACTACCC 180 CATTGCTGTC TTTATGAAAA GAAATTTCAT TTCAATATAG GTGACTATGC AGCCTGCAAT 240 TCAAGTATGG TTTGGAGAAG ATCTGCCTCT AAGTCCTCGG AGTCCTCTGA CTCCCAGACA 300 CGGACCAGGA TTGGCTAATG TTTGTCAGTA CGATGAGTGG ATAGCTGTGA GGCATGAAGC 360 CACTTTGTTG CCCATGCAAG AAGATCTGTC AATCTGGTTA TCTGGTTTAT TAGGTATTAA 420 AGTTAAGGCA GAAAAATTAT TGGAAGAACT TGATAATGGA GTACTATTAT GTCAACTGAT 480 TGATGTTCTT CAAAACATGG TGAAAACATG CAACTCTGAA GAATCAGGGA ATTTTCCAAT 540 GAGAAAAGTG CCCTGTAAGA AAGATGCTGC ATCAGGTTCA TTCTTTGCTC GGGACAATAC 600 CGCAAACTTC CTTCACTGGT GTAGGGACAT TGGGGTTGAT GAAACTTACC TCTTTGAATC 660 TGAAGGTTTA GTTTTGCACA AAGATCCAAG ACAGGTGTAT CTTTGTCTTC TTGAAATTGG 720 TCGAATTGTG TCAAGATACG GGGTTGAGCC ACCAGTGTTA GTAAAACTTG AGAAAGAAAT 780 TGAGTTAGAA GAGACTTTGC TTAATACTTC TGGGCCTGAA GATTCCATCA GCATTCCAAA 840 ATCATGCTGT CGGCATGAAG AGCTACATGA AGCTGTTAAA CATATTGCTG AGGACCCTCC 900 TTGTAGTTGT TCTCATCGAT TTTCTATTGA GTATTTATCT GAAGGACGGT ACCGACTAGG 960 GGATAAAATA CTCTTTATAA GAATGCTTCA TGGAAAACAT GTCATGGTTC GCGTTGGTGG 1020 AGGCTGGGAT ACTCTTCAAG GATTTTTGCT TAAATATGAC CCCTGTCGAA TATTACAGTT 1080 TGCCACATTA GAACAAAAAA TTTTAGCATT TCAAAAAGGA GTTTCTAATG AAAGTGTACC 1140 TGATTCGCCT GCCAGAACAC CTCAGCCTCC TGAAATGAAT CCTTTGTCAG CAGTTAACAT 1200 GTTTCAGAAA CAAAATTCAA AACCCAGCGT GCCAGTTAGT ATTCCAAAAA GCAAAGAAAA 1260 ACAGGGACGT CCACCAGGTG CATTGGTGCC AGCATCTTCA CTGAAAGGAG GTAATCTGGG 1320 CTCTATGTCA GTCCGTTCTA AATTGCCAAA TTCTCCAGCA GCATCTTCTC ATCCCAAGCT 1380 CAAGTCTTCA AAAGGCATAA CGAAGAAACC GCAGGCTCCT TCAAACAATG CATCATCTTC 1440 ACTTGCTTCA TTAAATCCAG TAGGTAAAAA CACTTCTTCA CCAGCTTTAC CAAGAACTGC 1500 ACCTTGTATA TCTGAGTCAC CGAGAAAATG TATTTCATCC CCCAATACCC CCAAGGCCAA 1560 GGTTATTCCA GCCCAGAATT CAGCAGATCT GCCCGAGTCC ACACTTTTGC CAAATAAGTG 1620 TTCAGGAAAA ACTCAACCTA AGTATTTGAA ACATAATCAT ATTTCTTCCA GAGATAATGC 1680 AGTATCTCAC TTAGCTGCAC ATTCAAATTC ATCCTCAAAA TGTCCCAAGC TGCCTAAAGC 1740 AAATATACCT GTAAGACCTA AACCTTCTTT CCAGTCCTCT GCAAAAATGA CAAAAACCAG 1800 TTCCAAAACC ATAGCCACGG GTCTAGGAAC ACAGTCTCAA CCATCCGATG GAGCCCCACA 1860 AGCAAAGCCA GTCCCAGCAC AGAAACTTAA ATCGGCCTTG AATTTAAATC AGCCAGTTTC 1920 TGTGTCCTCA GTTTCTCCTG TAAAAGCCAC ACAGAAATCA AAAGATAAGA ATATAGTTTC 1980 AGCTACCAAA AAGCAGCCTC AGAATAAAAG TGCATTTCAG AAGACAGGAC CCAGCTCCTT 2040 GAAGTCTCCT GGCCGTACCC CACTGTCCAT CGTGAGCCTA CCCCAGTCTT CTACCAAAAC 2100 ACAAACTGCA CCGAAGTCAG CACAGACTGT CGCTAAGAGC CAGCATTCAA CTAAAGGGCC 2160 TCCCAGAAGT GGCAAAACCC CAGCTTCAAT CAGGAAACCA CCCTCATCTG TTAAGGATGC 2220 AGATAGTGGA GATAAAAAAC CTACTGCAAA GAAAAAGGAA GATGATGACC ATTATTTTGT 2280 CATGACTGGA AGTAAGAAAC CTAGAAAATA AATACATACT CATTATAAAA AAAGAGAAAA 2340 GGAAGAATGA ATGTGTTAGC TTCACATCTT AAAAGTTTCT CCTATTTGTG TCTGTCTAAA 2400 TAGGTGCAGA CACTAAGGAT AGTGAGGATG GAGGCTGGGA TGAGGAAAGG GTTCATCAGA 2460 ATTCACATAT CTGAATTCAC TGGAAAGAGC CCTTCTGAAG CAAACAGTTG TAAAATCACT 2520 GCAAGGTTTT TATTAATAAT AGACATGTAT ATGATTTTCA GTCTATAGCA TCTTTGTTAA 2580 CATCTGCCTT TTGCAGGAAA TGTAAAAGTT ATTTAACACT ACAAGAATTT TAACAATAGT 2640 TGCTCTATTT TTGAATATGT ATTAAATATG GAGTTCATAT ACCTGCTAAT ATCAACGGTG 2700 GTGCTCTTAC TATTAGTTAA TTGCATTTTG GTTAAAAAAA AAAAAGCAAC AGTTTGGCAC 2760 TTGTCCTACA AAAGGCACCT AATTTAATTT TCTGATCAGG ATTGCCTGAT CCAACAGTGC 2820 TAAGTCATGG CTGCTGCTGA CTAGCTTGGC ATTATTCTGT GTTAGGTAGA ATTCTTATTA 2880 TTTATTTTTT TAAGCTTTCC AAATTGGAAG GAACTGATTG TTTCATGTGG CTTATATTTA 2940 CATTGGTAAT ATTTTGTCAC CAATATTTTT GGTTAAAAAA AATCCAACAA ATTAACTTAC 3000 TGAAATATAA ACAAATTTTG TAAACAATTT TTTATATTAT CTATAAAAAC GTAGACACCT 3060 TATGTTTCAC ATGTTGTGCA ATGTGACAGG GGAAGCTGAT TTAGTAGCTT TTAGCATATT 3120 AAAAATAATT TTTTATAATG TAATTTCCTG TGAGTGCAGA CCTGACATTT TACATTAAAA 3180 TAATGTGAAA CATCAGAATT ATGTTTTAAC AACTTTAAAA TTAAGATGAT GTTAAAATAA 3240 TTTTAGAGTT ATGCTATGGA AAAATTCTAT CATGAAATTA TTTTTCTCTA GATAGCACAA 3300 TACCAATTTT AATTAATTTC TTCCAATTAG GTTACTTTTC TTTAATAAAG TTATGCTGCC 3360

TTCAGTTTTC CAATGGCAAG TAGACAGGAT ATGTTCAAGG TTTTCTGCAC TGTAGGCACA 3420 GTCTCTCAAG CATATCCTGA TCATGTAATG ACTGCATAAA CTCCATCAAC CTAAGGTGAT 3480 ACTTGTAAAT AATTTATTTT TAAGGGATGG TGACTTTAAA AATTATTAAT GAACTTTGAG 3540 AAGTTTTAAG AGTGCTTTTA AAACTTCACA GTATTGCCAA TTATCTTAGG TTATTCAGTA 3600 TTCAGGTTTG TGTTTCTCTG TTTTAAACTA AAATGTGTTT TCTGAAGAAA AAAATAATAG 3660 TTTACACAAA TGTACAATCA TAGAATAAGC ATTTTAAGCT GGCGACTAGT GTTCTATAGA 3720 TTACAAAGCA AGAAAACTTT CTATGAAGAT AAATGACCTT TTGCCTGAAG AGTACAGATA 3780 AAATCAAAGA TGTGTGCAAG CTAGTTTTTG GAAGAAGTGA TGCTTCTCTT CTTTAAAGAG 3840 ACAGTCACCA AATACTTGGT TTAACTCGAC TATTGACTTG GGCATTGAGA GAGATGATAT 3900 ATACATCTTT GGAAAGTGAA GTCAATGTTC AAGAGGTGAT AGAAGCTTTA CTTTTTAGTG 3960 ATCAGAAATA TTTAGTGCAT CTTTTCAGAC AGGAAGAATT TTATCATCAA GTATTCCCTT 4020 ATAAAACCAA GTAACACTTC TTTATCAGTA ACTTTTAGAA CTTAAAAGAA AGCAAAAAGT 4080 AAATGGAATT GTAGGCAATT TATGAATCCT AGTAGATTTT ACAATATGTA ATTTATGTTG 4140 TTTACAGTAT ATAAACACTA AGTTTTGTGT TAAATGTGAT CAGGAATAAA AGTATCCCAC 4200 AGGCATCTGA CACAAATTCC AGAATTAGCC AAAGAATTGT TTATTTGAGG CCAGGCAATC 4260 CCAGCATTTT GGGAAGCCAA GTTGGGCAGA TCACGAAGTC AGGAGTTCGA AATCAGCCTG 4320 ACCAACATGG TGAAACCTCT TCTCTACTAA AAATACAAAA TTAGCCGGGC ATGGTGGCAC 4380 ATGCCTATAA TCTCAGCTAC TCAGGAGGCT GAGGCAGGAG GATCGCTTGA ACCCGGGAGG 4440 CAGAGGTTGC AGTGAGCCAA GATTGCGCCA CTGCACTCCA GCCTGGGCAA CAGAGTGAGA 4500 CTCTGTCTCA AAAAAAAAAA AAAAGAAAAA GAAAAGAAAA AGGTTTATTT GAATAATTGG 4560 AAGTCAGTTT ATACATTACT ATTTTTCAGC AGTAGGGAAT TTCTCCAATT ACATTCATGT 4620 TGAATGAATT TTTATTTATA TATAGCTTAC CCTTCCAAAA TAAAAGTGTT TTTTTAATGT 4680 TGTTTTGTTT TGTTTTGTTT TTTTCCTTTT TTGAGACGGA GTTTCACTCT TGTTGCCCAG 4740 ACTGGAGTGC AGTGGCACAA TCTCAGCTCA TTGCAACCTC TGCCTCCTGG GTTCAAGTGA 4800 TTCTGCTGCC TCAGCCTCCT GAGTGGTTGG GATTACAGGC ATCCACCACC AGGCCCAGCT 4860 AATTTTTTTG TATTTTCAGT AGAGATGGGG GTTTCACCAT GTCGGCCAGG CTGATCTCAA 4920 ACTCCTGACC TCAGGTGATC CACCTGCCTC AGCCTCCCAA AGCGCTGGGA TTACAGGCAT 4980 GAGCCATCAC ACCCAGCGAA AAGTTTTGTT TGAATAAACA ATATCCGAAA GACAATTAGT 5040 TTCTTCAGAT GTATTTTGAA ATTCTCCTAA AGAGCTAGTG TTTCTATTCA TTTTCACAAT 5100 TTAAAAACAG CTCTTAACAT TGCTGAAGTT GGGAGAACTT TCCATCTCTT CTTAATAACA 5160 GTGCAAGATT TTGTAAATTC TTTTTTGTGT TTAATGTTTA ATAAAACGAG TATTAAGCTT 5220 AAATTACTGA AGTACCTGGG AGAAGTAATG ATGTGTACTT TCAAAAAAAT GGAAAATGCT 5280 TTTATTTTAT TTTCTATAAT TTGTTAACAT GATATGTAAA ATTAAACTTC GGAGCACAAT 5340 GAAATGCCGA TTATTTTTAC CTTGTTTGGG CTTAAAGTAG GTATTTAAGG TTTATGTGTT 5400 CAAAATGCCT TGGTAAATTG GATGACCTCT AACTTTACTG TCCATATGGA GTTTGTCATT 5460 CTTTATGGAT AAGAGAACTT AAGGAAAAGT TACTGTTTTT CTTCAGTCTT TTTATATCTA 5520 TCTGATTTAA AATCTGTTAC TTTATTAAAA GGCTTCAACA ACAGGTTGTT AGGATGTAGT 5580 CTTACATCCA GGTTCACATA ATAACCCCAT TTGAATCCAA ATTTGTGTAT ATTTTCTTAT 5640 GCCAGCAGTA TTTGTATCCA ATTTTAACTT AGGTTTGTTT TCTTGAG 5687 Seq ID NO : 60 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TTTTTTTTTT TTTTTTTAAA TCACAACACC TCTGAATATG TTTAATGACA GAGCAATTAG 60 AAACAAAAGT TTAATTTTAT ACATCATAGA ATTACTATTT AGAAACAAAT AGGACATGTT 120 AGAAGTAAGA AAAAATAAAA CACTTTGTTG AAGTTATATA CCTATTTGGA TTTTTTTAAA 180 AGCATTACCC AATAGGCTAT AGAACGATGC CAACACATAA TGCCAGGTTG CAAGGCATGG 240 AGAATGGGAG AATGTGACAT GACTGTCTAA TGGGTATAAA GCTCCCTTTT GAAGTGAAAA 300 AATTACTTTG GATCTAGATA GTAGTGGTAC TGGCAAATGT GCTAAACGCC AATGAATAAT 360 GCACATTAAA TGGTTTAATT GTATAATTTT GTGGTGTAAA ATTCCTATAT CAATTATTCT 420 TTAAATAAAC AAGTGGCTGA CCAGATTTGA CCAAGAGACC ATAGTTTGTC AGCCCTTGGT 480 TTATGCTACA AATTTAATTC CCATATGCTT GAAATAGTAA ATGCTGTCAT TTTAATCATT 540 TACATTAGAA ACATGGGATG TTTTGAAACT ATAATATGTT ATGCAATTAT ATGAACACTA 600 AAATTATTAC TGTGGAATTT TTTTATTTGT AGTAACGGGA GTATGCAATT TTATTTTGCT 660 GTACACA 667 Seq ID NO : 61 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 GACCTAAGAA CTTATCAAAG AACTCAGCAG TATGAGAATA GATCAATACA TAGAGGGTTT 60 CCTTTAAGTC TTGTAGAAAC TCATTACTCT CCAGTCTCTT TTTCCACTTA TAGTAGAGAG 120 AATCAGACTT GCGGATATCC AGTTAACTAT CAATACCTTT AAAAAATGTG AACAAGCAGT 180 CCATCTGAAT AATTATACCA AATGTCAAGG CTTTTAAAAG TGCTTAACTT TAAAGGTCCT 240 TTGCAGTTGT TCAGACCTAG ATTCTCAGTT CAGTTAGCAC AGAGAGAGAC AAGGAAAAAA 300 TGAGGAACAC TTTTCTCACG CATAAATATT CACTGGTTTT TGAAATACTA TTGATTCCTT 360 GGATAAGAAA ATAGGTCAAC TTTATAGCTT TTTGTCTCGA AATTGATTTG CCGCCACAGA 420 CAGTGGCTTG GTGCCTATAA TCCCAGCCTA CATGGGAGGC TGAGGTGGGA GATCGCTTGA 480 GCCCAAAAAG TCAGAGGTGC AGTGAGCTGT GATTGTGCCA CTGTATCCCA ACCTCAT 537 Seq ID NO : 62 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 ( TTTTTTTTTT TTTTAATTTT AATAAGTTAA ATTTTTAATA ATTGATTTAT TTATACTCCA 60 AAGGATACAA CATGCAAAAT GTCTACCCAC TCCAGCTACC ATCAGTTCAG CATTTATAAC 120 TACTATCAAT AATGTTTTCA TGTAAGACAG CCATCACCTA AAGGAATACT TTTAAAACAG 180 GTTGTACAAT AAAACAGGTT GGACCAATAT AAAAGAAATA TAAAATAAGG TGGTTTATTT 240 AAATGTAAAT ACACAGATAC TTCCATTAAA TCTAAACAAA CTTTAAAAAG AGGAGCAAAT 300 AATGAGTAAT GCCATAGAAC ATTAGAAGAA CACAGTTAAC GAATGGAAAC TTGTAACACG 360 ATACACACAC ACGCATGCAT ATATATATGT ATCATATATA TCAACTAAAA GACATTTTCT 420 TAGAGCATAT TGAATTGTTA ATAATTATTT GAAGTGACAT GTGGTGGGAC ATAAATCAAG 480 ACTCAGTAAA TTTGAAAAGA TTCAATATCA TAAAGAATAT ATGATCCAGC CTTAGTAGAA 540

GTAAGGGAAA TTTAAAAAAT GTAACTAAAA TATCTTTAAT TTTGGAAATT AAGAAAATAC 600 ACTTCAAAAA AATTTAAAGT CCTGCCTCAG CCTCCCCAGT AGCTGGGATT ACAAGCATGC 660 ACCACCATGT CCAGCCAATT TTGTAATTAT AGTAGAGACA GG 702 Seq ID NO : 63 DNA Sequence Nucleic Acid Accession # : AK025967 1 11 21 31 41 51 ACAACAGGAA CACATATAGC TGGAATGCAG ATGGGATCTG TGCTACTTAC GCTAGCCATG 60 GGATGATTAG AACAAGATAA GAGACATGAG GAAGACTTCT TCAAGGAGGT GCTCAAGCCA 120 TGTTTTGGAA AAGAGAACTC AAGGTCTGGC AGGGAGAAAG GAGCAAGGTC CTCTTCTCCC 180 TGAAGGCTGT CACAGTTCCT GTGCAGAGAG AGAGGGCACT GCAGCACCCA GGCGCTGACT 240 GCCTTTTGTC AGTCTCATTT GCAGGCCCCC AGCTGGAGAA CCCAGGAGGA AGAGGAAAAA 300 AGTTTTTTCC TCCTCTACAC TCCCCATGCA TGACTAAAGA GTAGGAGGAG TCAGCAAGGC 360 AGACATATAT AGTACCCAGG AGGTGGACAA ACAACTGCCT TGGTGGAAAC TCTGTCCTTT 420 CTGGACTTAT CCTGGTGCCA CTGAGACTGT GCAGATTTAG ATCTACAATC CACCTGGAAT 480 TGATTTTTGT ATATGGAGTG AGGTCCCACA CTTACAGGGA AAGCATCACC CGAAAGTGAG 540 AATGCCTAGA GGCAGGAATC ATGGAGGCTT CCTTAACCGT CTGTCTGCAA CAGCAGGTGC 600 TAGAGATGAC ACTGCAGAGT AGAGAACAAA GGAATCTTAG TAATTGTTCA ATCCAATCTC 660 CACACTTTAA AGATGAAGAA ACTGGTATTG AGAAAAATAC ACAGCTTATC CAAGGTTGCA 720 CTGCTGGTTG GTAGCTGAGA TGAATTTAGA ACCCACATCT GATGACTACA CCATATTGCT 780 CCCAGTTTTC CTGTCTGTTC CACATGTAAA AGTCTGACTC TTCACTTCTC CTTTGAGTAT 840 ATAGACTTTT AACATTTTTG TATGTCAAGA TGGACTTTTC CTCATACCCA GCCCCTGCCT 900 TTTCTCCTCC CTTCATACCT TGCAGGATCT TTAACAGAAT TTAAAAGGAG TTTTTTGTTT 960 TGTTTTGATG TATCTAATAA AAGTCAAGGG AGGGAGAGGG CCAGTATAAG CAAGAGTACA 1020 GTTTCCTAGT TTGTAGATGC GGTAGTCTGA GGAATCAGAA ACACACAAAG GTTTGGAGAA 1080 CTGGTACATG CTCCCAGGTG GGAAGCCAGG ACTCTTGGTA GGATCTTGAG GACAAGGCAA 1140 AGGACAATAA GAGAGCGAGG GGATCCTAGA GGTGGAATCA AGGAAGAGAA ACTAGAGAGA 1200 GAAAAAGGAA CTGGCTATCC ATCCATGATG GATCCTGTGT GGACTGATGG GTGGCTTGGC 1260 ATCATCCTTT AGTAGACTTC ATGTGGTTGA ATAATTGGCC AATGGAAGGA ATTTCTTTTT 1320 TGGTAACAGA CTCTGTGTGT ACAGTTATGG GTCTTAATTT ATAATAAAAG GTTACATTGA 1380 AAATTGAAAA AAAAAAAA 1398 Seq ID NO : 64 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 GGCACGAGGA GAGAAACTCC ATCTCAAAAA CAAAACAACA CAAAACAAAA AAAGAAGAGA 60 AATCAAAGCT TGTTCCCTGT CTCTCTCTCT CCACATGTGA GCACACAAAG AGGTCACGTG 120 AACACACAAT GAGAAGGAGG CTGCCTGCAA GTTAAGAGAA GAGGCCTCAG CATGAAACCT 180 GCCTTACTGG CACTTTGGTC TTGAACTTCC CAGCCTCTAA AACTGTGAGA AATAAGTTTC 240 TGTTGTTCAA GCCACCCAGT CTATGGTATT CTGTATGGCA GCCAGAATTA AGACACCAGT 300 GAAGCAAGAT AATCAGTAAC TGGATACTTA ACTGTGTGGT ATAAAACATA GGGGCTTTAG 360 TAGAGAAGAA AATTGGACTT TGTTGGGGAC ATCCTTACTA CTTCTGCTCA TGTATCATGC 420 TTTAGCTTGT TTCTGTCTTT GGAGGAGGCT GCATATTTTT AAAATACCCC CAAAAGTACA 480 AAGACTAATG TTATAGCCCC TGTGTTCTCA TTATCCAGGC TTAATAAATG TTGGCCATTT 540 TCCACTTTTG TTTCATATAT AAGTTTCTAC AAAATGACAA CACCTTAGAT AAAGCTGAAG 600 TTCATGTTTC ATTCTGCATC CCTTCCCCCA AGGGCTTCTT TTGCTCAATA TGGGACTCAT 660 GAGAGTCATC GGTGTTGTGT GAGGCAGCTG TTTGTTGATT TTCTGGACCA AATAATGTTC 720 CACCGTGTGA CTGGACATAC CTTAGTCTAT CCATTCTACC ACTGATGAGC ATGTAAGCTG 780 TTACTATTTT TAACTATTAC AAATTATCTT GCTAACACAT TTTTGTGCAT GTCTTTTGGT 840 GACCAAATGG ACTCATTTCT CTCAGGTATG TATCTCAGAG TGAAACTGTT TTATCACAGT 900 GTATGCTTTA TATTTAGTGC TTTCCAATTC CTGATTAAGA AATCTTTGCC TGCTCCTAAG 960 GATGTAAAAT TATTCTCTTA TGGCCTGGCT CAGTGGCTCA TGCCTGTAAT CCCAGCATTT 1020 TGGGAGGCCA AGGTGGGAGG ATTGCTTGAG GCCAGGAGTT CAAGACCAGC CTGGGCAACA 1080 TACTGAGACC CTCATCTCTA CAAAAAAAAA AAATTTGTTT AATTAGCTGA GCTTGGTGGT 1140 ATGCACCTAT AGTCCTAGCT ACTCAGGAGG CTGAGGCAGG AGGATCGCTT GAGCCCAGGA 1200 ATTCAGAGAT GCAGTAAGCT ATGATCATGC CACTGTATTA CAGCCTGGGT GATAGGGTGA 1260 GACCCTGTCT CTAAAAAGAT ACATCTATTA AAAATAATAT TATTTTATTT TATTTTATTT 1320 TATTTTATTA TTATACTTTA AGTTTTAGGG TACATGTGCA CATTGTGCAG GTTAGTTACA 1380 TATGTATACA TGTGCCATGC TGGTGCACTG CACCCACTAA CTCGTCATCT AGCATTAGGT 1440 ATATCTCCCA GTGCTATCCC TCCCCCCTCC CCCGACCCCA CAACAGTCCC CAGAGTGTGA 1500 TGTTCCCCTT CCTGTGTCCA TGTGATCTCA TTGTTCAATT CCCACCTATG AGTGAGAATA 1560 TGCGGTGTTT GGTTTTTTGT TCTTGCGATA GTTTACTGAG AATGATGATT TCCAATTTCA 1620 TCCATGTCCC TACAAAGGAC ATGAACTCAT CATTTTTTAT GGCTGCATAG TAAAAATACA 1680 TTTTAAAAAA TAATAAATTA TTCTCTTATG TTATTGTCTA GAATCTTCAT TATTTTACCT 1740 TTCAGATTTA GATCTACAAT CCACCTGGAA TTGATTTTTG TATATGGAGT GAGGTCCCAC 1800 ACTTACAGGG AAAGCATCAC CCGAAAGTGA GAATGCCTAG AGGCAGGAAT CATGGAGGCT 1860 TCCTTAACCG TCTGTCTGCA ACAGCAGGTG CTAGAGATGA CACTGCAGAG TAGAGAACAA 1920 AGGAATCTTA GTAATTGTTC AATCCAATCT CCACACTTTA AAGATGAAGA AACTGGTATT 1980 GAGAAAAATA CACAGCTTAT CCAAGGTTGC ACTGCTGGTT GGTAGCTGAG ATGAATTTAG 2040 AACCCACATC TGATGACTAC ACCATATTGC TCCCAGTTTT CCTGTCTGTT CCACATGTAA 2100 AAGTCTGACT CTTCACTTCT CCTTTGAGTA TATAGACTTT TAACATTTTT GTATGTCAAG 2160 ATGGACTTTT CCTCATACCC AGCCCCTGCC TTTTCTCCTC CCTTCATACC TTGCAGGATC 2220 TTTAACAGAA TTTAAAAGGA GTTTTTTGTT TTGTTTTGAT GTATCTAATA AAAGTCAAGG 2280 GAGGGAGAGG GCCAGTATAA GCAAGAGTAC AGTTTCCTAG TTTGTAGATG CGGTAGTCTG 2340 AGGAATCAGA AACACACAAA GGTTTGGAGA ACTGGTACAT GCTCCCAGGT GGGAAGCCAG 2400 GACTCTTGGT AGGATCTTGA GGACAAGGCA AAGGACAATA AGAGAGCGAG GGGATCCTAG 2460 AGGTGGAATC AAGGAAGAGA AACTAGAGAG AGAAAAAGGA ACTGGCTATC CATCCATGAT 2520 GGATCCTGTG TGGACTGATG GGTGGCTTGG CATCATCCTT TAGTAGACTT CATGTGGTTG 2580 AATAATTGGC CAATGGAAGG AATTTCTTTT TTGGTAACAG ACTCTGTGTG TACAGTTATG 2640 GGTCTTAATT TATAATAAAA GGTTACATTG AAAATTGAAA AAAAAAAAAA AAAAAAAAAA 2700 GCATTATAAG TGTACTTCTA GCCTTACTTC GTCGGGGTAA TTCGATCTCG CTCTTGCTGG 2760 CTG 2763

Seq ID NO : 65 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 1.. 1863 1 11 21 31 41 51 ATGAGTAAGA GCAAATGCTC CGTGGGACTC ATGTCTTCCG TGGTGGCCCC GGCTAAGGAG 60 CCCAATGCCG TGGGCCCGAA GGAGGTGGAG CTCATCCTTG TCAAGGAGCA GAACGGAGTG 120 CAGCTCACCA GCTCCACCCT CACCAACCCT CGGCAGAGCC CCGTGGAGGC CCAGGATCGG 180 GAGACCTGGG GCAAGAAGAT CGACTTTCTC CTGTCCGTCA TTGGCTTTGC TGTGGACCTG 240 GCCAACGTCT GGCGGTTCCC CTACCTGTGC TACAAAAATG GTGGCGGTGC CTTCCTGGTC 300 CCCTACCTGC TCTTCATGGT CATTGCTGGG ATGCCACTTT TCTACATGGA GCTGGCCCTC 360 GGCCAGTTCA ACAGGGAAGG GGCCGCTGGT GTCTGGAAGA TCTGCCCCAT ACTGAAAGGT 420 GTGGGCTTCA CGGTCATCCT CATCTCACTG TATGTCGGCT TCTTCTACAA CGTCATCATC 480 GCCTGGGCGC TGCACTATCT CTTCTCCTCC TTCACCACGG AGCTCCCCTG GATCCACTGC 540 AACAACTCCT GGAACAGCCC CAACTGCTCG GATGCCCATC CTGGTGACTC CAGTGGAGAC 600 AGCTCGGGCC TCAACGACAC TTTTGGGACC ACACCTGCTG CCGAGTACTT TGAACGTGGC 660 GTGCTGCACC TCCACCAGAG CCATGGCATC GACGACCTGG GGCCTCCGCG GTGGCAGCTC 720 ACAGCCTGCC TGGTGCTGGT CATCGTGCTG CTCTACTTCA GCCTCTGGAA GGGCGTGAAG 780 ACCTCAGGGA AGGTGGTATG GATCACAGCC ACCATGCCAT ACGTGGTCCT CACTGCCCTG 840 CTCCTGCGTG GGGTCACCCT CCCTGGAGCC ATAGACGGCA TCAGAGCATA CCTGAGCGTT 900 GACTTCTACC GGCTCTGCGA GGCGTCTGTT TGGATTGACG CGGCCACCCA GGTGTGCTTC 960 TCCCTGGGCG TGGGGTTCGG GGTGCTGATC GCCTTCTCCA GCTACAACAA GTTCACCAAC 1020 AACTGCTACA GGGACGCGAT TGTCACCACC TCCATCAACT CCCTGACGAG CTTCTCCTCC 1080 GGCTTCGTCG TCTTCTCCTT CCTGGGGTAC ATGGCACAGA AGCACAGTGT GCCCATCGGG 1140 GACGTGGCCA AGGACGGGCC AGGGCTGATC TTCATCATCT ACCCGGAAGC CATCGCCACG 1200 CTCCCTCTGT CCTCAGCCTG GGCCGTGGTC TTCTTCATCA TGCTGCTCAC CCTGGGTATC 1260 GACAGCGCCA TGGGTGGTAT GGAGTCAGTG ATCACCGGGC TCATCGATGA GTTCCAGCTG 1320 CTGCACAGAC ACCGTGAGCT CTTCACGCTC TTCATCGTCC TGGCGACCTT CCTCCTGTCC 1380 CTGTTCTGCG TCACCAACGG TGGCATCTAC GTCTTCACGC TCCTGGACCA TTTTGCAGCC 1440 GGCACGTCCA TCCTCTTTGG AGTGCTCATC GAAGCCATCG GAGTGGCCTG GTTCTATGGT 1500 GTTGGGCAGT TCAGCGACGA CATCCAGCAG ATGACCGGGC AGCGGCCCAG CCTGTACTGG 1560 CGGCTGTGCT GGAAGCTGGT CAGCCCCTGC TTTCTCCTGT TCGTGGTCGT GGTCAGCATT 1620 GTGACCTTCA GACCCCCCCA CTACGGAGCC TACATCTTCC CCGACTGGGC CAACGCGCTG 1680 GGCTGGGTCA TCGCCACATC CTCCATGGCC ATGGTGCCCA TCTATGCGGC CTACAAGTTC 1740 TGCAGCCTGC CTGGGTCCTT TCGAGAGAAA CTGGCCTACG CCATTGCACC CGAGAAGGAC 1800 CGTGAGCTGG TGGACAGAGG GGAGGTGCGC CAGTTCACGC TCCGCCACTG GCTCAAGGTG 1860 TAG 1863 Seq ID NO : 66 DNA Sequence Nucleic Acid Accession # : NM 022073. 1 Coding sequence : 327.. 1046 1 11 21 31 41 51 GAGTCTGGCC GCAGTCGCGG CAGTGGTGGC TTCCCATCCC CAAAAGGCGC CCTCCGACTC 60 CTTGCGCCGC ACTGCTCGCC GGGCCAGTCC GGAAACGGGT CGTGGAGCTC CGCACCACTC 120 CCGCTGGTTC CCGAAGGCAG ATCCCTTCTC CCGAGAGTTG CGAGAAACTT TCCCTTGTCC 180 CCGACGCTGC AGCGGCTCGG GTACCGTGGC AGCCGCAGGT TTCTGAACCC CGGGCCACGC 240 TCCCCGCGCC TCGGCTTCGC GCTCGTGTAG ATCGTTCCCT CTCTGGTTGC ACGCTGGGGA 300 TCCCGGACCT CGATTCTGCG GGCGAGATGC CCCTGGGACA CATCATGAGG CTGGACCTGG 360 AGAAAATTGC CCTGGAGTAC ATCGTGCCCT GTCTGCACGA GGTGGGCTTC TGCTACCTGG 420 ACAACTTCCT GGGCGAGGTG GTGGGCGACT GCGTCCTGGA GCGCGTCAAG CAGCTGCACT 480 GCACCGGGGC CCTGCGGGAC GGCCAGCTGG CGGGGCCGCG CGCCGGCGTC TCCAAGCGAC 540 ACCTGCGGGG CGACCAGATC ACGTGGATCG GGGGCAACGA GGAGGGCTGC GAGGCCATCA 600 GCTTCCTCCT GTCCCTCATC GACAGGCTGG TCCTCTACTG CGGGAGCCGG CTGGGCAAAT 660 ACTACGTCAA GGAGAGGTCT AAGGCAATGG TGGCTTGCTA TCCGGGAAAT GGAACAGGTT 720 ATGTTCGCCA CGTGGACAAC CCCAACGGTG ATGGTCGCTG CATCACCTGC ATCTACTATC 780 TGAACAAGAA TTGGGATGCC AAGCTACATG GTGGGATCCT GCGGATATTT CCAGAGGGGA 840 AATCATTCAT AGCAGATGTG GAGCCCATTT TTGACAGACT CCTGTTCTTC TGGTCAGATC 900 GTAGGAACCC ACACGAAGTG CAGCCCTCTT ACGCAACCAG ATATGCTATG ACTGTCTGGT 960 ACTTTGATGC TGAAGAAAGG GCAGAAGCCA AAAAGAAATT CAGGAATTTA ACTAGGAAAA 1020 CTGAATCTGC CCTCACTGAA GACTGACCGT GCTCTGAAAT CTGCTGGCCT TGTTCATTTT 1080 AGTAACGGTT CCTGAATTCT CTTAAATTCT TTGAGATCCA AAGATGGCCT CTTCAGTGAC 1140 AACAATCTCC CTGCTACTTC TTGCATCCTT CACATCCCTG TCTTGTGTGT GGTACTTCAT 1200 GTTTTCTTGC CAAGACTGTG TTGATCTTCA GATACTCTCT TTGCCAGATG AAGTTATTTG 1260 CTAACTCCAG AAATTCCTGC AGACATCCTA CTCGGCCAGC GGTTTACCTG ATAGATTCGG 1320 TAATACTATC AAGAGAAGAG CCTAGGAGCA CAGCGAGGGA ATGAACCTTA CTTGCACTTT 1380 ATGTATACTT CCTGATTTGA AAGGAGGAGG TTTGAAAAGA AAAAAATGGA GGTGGTAGAT 1440 GCCACAGAGA GGCATCACGG AAGCCTTAAC AGCAGGAAAC AGAGAAATTT GTGTCATCTG 1500 AACAATTTCC AGATGTTCTT AATCCAGGGC TGTTGGGGTT TCTGGAGAAT TATCACAACC 1560 TAATGACATT AATACCTCTA GAAAGGGCTG CTGTCATAGT GAACAATTTA TAAGTGTCCC 1620 ATGGGGCAGA CACTCCTTTT TTCCCAGTCC TGCAACCTGG ATTTTCTGCC TCAGCTCCAT 1680 TTTGCTGAAA ATAATGACTT TCTGAATAAA GATGGCAACA CAATTTTTTC TCCATTTTCA 1740 GTTCTTACCT GGGAACCTAA TTCCCCAGAA GCTAAAAAAC TAGACATTAG TTGTTTTGGT 1800 TGCTTTGTTG GAATGGAATT TAAATTTAAA TGAAAGGAAA AATATATCCC TGGTAGTTTT 1860 GTGTTAACCA CTGATAACTG TGGAAAGAGC TAGGTCTACT GATATACAAT AAACATGTGT 1920 GCATCTTGAA CAATTTGAGA GGGGAGGTGG AGTTGGAAAT GTGGGTGTTC CTGTTTTTTT 1980 TTTTTTTTTT TTTTTTTTTT AGTTTTCCTT TTTAATGAGC TCACCCTTTA ACACAAAAAA 2040 AGCAGGGTGA TGTATTTTAA AAAAGGAAGT GGAAATAAAA AAATCTCAAA GCTATTTGAG 2100 TTCTCGTCTG TCCCTAGCAG TCTTTCTTCA GCTCACTTGG CTCTCTAGAT CCACTGTGGT 2160 TGGCAGTATG ACCAGAATCA TGGAACTTGC TAGAACTGTG GAAGCTTCTA CTCCTGCAGT 2220 AAGCACAGAT CGCACTGCCT CAATAACTTG GTATTGAGCA CGTATTTTGC AAAAGCTACT 2280 TTTCCTAGTT TTCAGTATTA CTTTCATGTT TTAAAAATCC CTTTAATTTC TTGCTTGAAA 2340 ATCCCATGAA CATTAAAGAG CCAGAAATAT TTTCCTTTGT TATGTACGGA TATATATATA 2400

TATATAGTCT TCCAAGATAG AAGTTTACTT TTTCCTCTTC TGGTTTTGGA AAATTTCCAG 2460 ATAAGACATG TCACCATTAA TTCTCAACGA CTGCTCTATT TTGTTGTACG GTAATAGTTA 2520 TCACCTTCTA AATTACTATG TAATTTACTC ACTTATTATG TTTATTGTCT TGTATCCTTT 2580 CTCTGGAGTG TAAGCACAAT GAAGACAGGA ATTTTGTATA TTTTTAACCA ATGCAACATA 2640 CTCTCAGCAC CTAAAATAGT GCCGGGAACA TAGTAAGGGC TCAGTAAATA CTTGTTGAAT 2700 AAACTCAGTC TCCTACATTA GCATTCTAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 2760 AAAAAAAAAG 2770 Seq ID NO : 67 DNA Sequence Nucleic Acid Accession ft : NM 139314. 1 Coding sequence : 196.. 1416 1 11 21 31 41 51 ATAAAAACCG TCCTCGGGCG CGGCGGGGAG AAGCCGAGCT GAGCGGATCC TCACACGACT 60 GTGATCCGAT TCTTTCCAGC GGCTTCTGCA ACCAAGCGGG TCTTACCCCC GGTCCTCCGC 120 GTCTCCAGTC CTCGCACCTG GAACCCCAAC GTCCCCGAGA GTCCCCGAAT CCCCGCTCCC 180 AGGCTACCTA AGAGGATGAG CGGTGCTCCG ACGGCCGGGG CAGCCCTGAT GCTCTGCGCC 240 GCCACCGCCG TGCTACTGAG CGCTCAGGGC GGACCCGTGC AGTCCAAGTC GCCGCGCTTT 300 GCGTCCTGGG ACGAGATGAA TGTCCTGGCG CACGGACTCC TGCAGCTCGG CCAGGGGCTG 360 CGCGAACACG CGGAGCGCAC CCGCAGTCAG CTGAGCGCGC TGGAGCGGCG CCTGAGCGCG 420 TGCGGGTCCG CCTGTCAGGG AACCGAGGGG TCCACCGACC TCCCGTTAGC CCCTGAGAGC 480 CGGGTGGACC CTGAGGTCCT TCACAGCCTG CAGACACAAC TCAAGGCTCA GAACAGCAGG 540 ATCCAGCAAC TCTTCCACAA GGTGGCCCAG CAGCAGCGGC ACCTGGAGAA GCAGCACCTG 600 CGAATTCAGC ATCTGCAAAG CCAGTTTGGC CTCCTGGACC ACAAGCACCT AGACCATGAG 660 GTGGCCAAGC CTGCCCGAAG AAAGAGGCTG CCCGAGATGG CCCAGCCAGT TGACCCGGCT 720 CACAATGTCA GCCGCCTGCA CCGGCTGCCC AGGGATTGCC AGGAGCTGTT CCAGGTTGGG 780 GAGAGGCAGA GTGGACTATT TGAAATCCAG CCTCAGGGGT CTCCGCCATT TTTGGTGAAC 840 TGCAAGATGA CCTCAGATGG AGGCTGGACA GTAATTCAGA GGCGCCACGA TGGCTCAGTG 900 GACTTCAACC GGCCCTGGGA AGCCTACAAG GCGGGGTTTG GGGATCCCCA CGGCGAGTTC 960 TGGCTGGGTC TGGAGAAGGT GCATAGCATC ACGGGGGACC GCAACAGCCG CCTGGCCGTG 1020 CAGCTGCGGG ACTGGGATGG CAACGCCGAG TTGCTGCAGT TCTCCGTGCA CCTGGGTGGC 1080 GAGGACACGG CCTATAGCCT GCAGCTCACT GCACCCGTGG CCGGCCAGCT GGGCGCCACC 1140 ACCGTCCCAC CCAGCGGCCT CTCCGTACCC TTCTCCACTT GGGACCAGGA TCACGACCTC 1200 CGCAGGGACA AGAACTGCGC CAAGAGCCTC TCTGGAGGCT GGTGGTTTGG CACCTGCAGC 1260 CATTCCAACC TCAACGGCCA GTACTTCCGC TCCATCCCAC AGCAGCGGCA GAAGCTTAAG 1320 AAGGGAATCT TCTGGAAGAC CTGGCGGGGC CGCTACTACC CGCTGCAGGC CACCACCATG 1380 TTGATCCAGC CCATGGCAGC AGAGGCAGCC TCCTAGCGTC CTGGCTGGGC CTGGTCCCAG 1440 GCCCACGAAA GACGGTGACT CTTGGCTCTG CCCGAGGATG TGGCCGTTCC CTGCCTGGGC 1500 AGGGGCTCCA AGGAGGGGCC ATCTGGAAAC TTGTGGACAG AGAAGAAGAC CACGACTGGA 1560 GAAGCCCCCT TTCTGAGTGC AGGGGGGCTG CATGCGTTGC CTCCTGAGAT CGAGGCTGCA 1620 GGATATGCTC AGACTCTAGA GGCGTGGACC AAGGGGCATG GAGCTTCACT CCTTGCTGGC 1680 CAGGGAGTTG GGGACTCAGA GGGACCACTT GGGGCCAGCC AGACTGGCCT CAATGGCGGA 1740 CTCAGTCACA TTGACTGACG GGGACCAGGG CTTGTGTGGG TCGAGAGCGC CCTCATGGTG 1800 CTGGTGCTGT TGTGTGTAGG TCCCCTGGGG ACACAAGCAG GCGCCAATGG TATCTGGGCG 1860 GAGCTCACAG AGTTCTTGGA ATAAAAGCAA CCTCAGAACA CTTAAAAAAA AAAAAAAAAA 1920 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA 1967 Seq ID NO : 68 DNA Sequence Nucleic Acid Accession # : Nom 016109. 2 Coding sequence : 196.. 1416 1 11 21 31 41 51 ATAAAAACCG TCCTCGGGCG CGGCGGGGAG AAGCCGAGCT GAGCGGATCC TCACACGACT 60 GTGATCCGAT TCTTTCCAGC GGCTTCTGCA ACCAAGCGGG TCTTACCCCC GGTCCTCCGC 120 GTCTCCAGTC CTCGCACCTG GAACCCCAAC GTCCCCGAGA GTCCCCGAAT CCCCGCTCCC 180 AGGCTACCTA AGAGGATGAG CGGTGCTCCG ACGGCCGGGG CAGCCCTGAT GCTCTGCGCC 240 GCCACCGCCG TGCTACTGAG CGCTCAGGGC GGACCCGTGC AGTCCAAGTC GCCGCGCTTT 300 GCGTCCTGGG ACGAGATGAA TGTCCTGGCG CACGGACTCC TGCAGCTCGG CCAGGGGCTG 360 CGCGAACACG CGGAGCGCAC CCGCAGTCAG CTGAGCGCGC TGGAGCGGCG CCTGAGCGCG 420 TGCGGGTCCG CCTGTCAGGG AACCGAGGGG TCCACCGACC TCCCGTTAGC CCCTGAGAGC 480 CGGGTGGACC CTGAGGTCCT TCACAGCCTG CAGACACAAC TCAAGGCTCA GAACAGCAGG 540 ATCCAGCAAC TCTTCCACAA GGTGGCCCAG CAGCAGCGGC ACCTGGAGAA GCAGCACCTG 600 CGAATTCAGC ATCTGCAAAG CCAGTTTGGC CTCCTGGACC ACAAGCACCT AGACCATGAG 660 GTGGCCAAGC CTGCCCGAAG AAAGAGGCTG CCCGAGATGG CCCAGCCAGT TGACCCGGCT 720 CACAATGTCA GCCGCCTGCA CCGGCTGCCC AGGGATTGCC AGGAGCTGTT CCAGGTTGGG 780 GAGAGGCAGA GTGGACTATT TGAAATCCAG CCTCAGGGGT CTCCGCCATT TTTGGTGAAC 840 TGCAAGATGA CCTCAGATGG AGGCTGGACA GTAATTCAGA GGCGCCACGA TGGCTCAGTG 900 GACTTCAACC GGCCCTGGGA AGCCTACAAG GCGGGGTTTG GGGATCCCCA CGGCGAGTTC 960 TGGCTGGGTC TGGAGAAGGT GCATAGCATC ACGGGGGACC GCAACAGCCG CCTGGCCGTG 1020 CAGCTGCGGG ACTGGGATGG CAACGCCGAG TTGCTGCAGT TCTCCGTGCA CCTGGGTGGC 1080 GAGGACACGG CCTATAGCCT GCAGCTCACT GCACCCGTGG CCGGCCAGCT GGGCGCCACC 1140 ACCGTCCCAC CCAGCGGCCT CTCCGTACCC TTCTCCACTT GGGACCAGGA TCACGACCTC 1200 CGCAGGGACA AGAACTGCGC CAAGAGCCTC TCTGGAGGCT GGTGGTTTGG CACCTGCAGC 1260 CATTCCAACC TCAACGGCCA GTACTTCCGC TCCATCCCAC AGCAGCGGCA GAAGCTTAAG 1320 AAGGGAATCT TCTGGAAGAC CTGGCGGGGC CGCTACTACC CGCTGCAGGC CACCACCATG 1380 TTGATCCAGC CCATGGCAGC AGAGGCAGCC TCCTAGCGTC CTGGCTGGGC CTGGTCCCAG 1440 GCCCACGAAA GACGGTGACT CTTGGCTCTG CCCGAGGATG TGGCCAAGAC CACGACTGGA 1500 GAAGCCCCCT TTCTGAGTGC AGGGGGGCTG CATGCGTTGC CTCCTGAGAT CGAGGCTGCA 1560 GGATATGCTC AGACTCTAGA GGCGTGGACC AAGGGGCATG GAGCTTCACT CCTTGCTGGC 1620 CAGGGAGTTG GGGACTCAGA GGGACCACTT GGGGCCAGCC AGACTGGCCT CAATGGCGGA 1680 CTCAGTCACA TTGACTGACG GGGACCAGGG CTTGTGTGGG TCGAGAGCGC CCTCATGGTG 1740 CTGGTGCTGT TGTGTGTAGG TCCCCTGGGG ACACAAGCAG GCGCCAATGG TATCTGGGCG 1800 GAGCTCACAG AGTTCTTGGA ATAAAAGCAA CCTCAGAACA CTT 1843

Seq ID NO : 69 DNA Sequence Nucleic Acid Accession # : Nom 001216. 1 Coding sequence : 43.. 1422 1 11 21 31 41 51 GCCCGTACAC ACCGTGTGCT GGGACACCCC ACAGTCAGCC GCATGGCTCC CCTGTGCCCC 60 AGCCCCTGGC TCCCTCTGTT GATCCCGGCC CCTGCTCCAG GCCTCACTGT GCAACTGCTG 120 CTGTCACTGC TGCTTCTGAT GCCTGTCCAT CCCCAGAGGT TGCCCCGGAT GCAGGAGGAT 180 TCCCCCTTGG GAGGAGGCTC TTCTGGGGAA GATGACCCAC TGGGCGAGGA GGATCTGCCC 240 AGTGAAGAGG ATTCACCCAG AGAGGAGGAT CCACCCGGAG AGGAGGATCT ACCTGGAGAG 300 GAGGATCTAC CTGGAGAGGA GGATCTACCT GAAGTTAAGC CTAAATCAGA AGAAGAGGGC 360 TCCCTGAAGT TAGAGGATCT ACCTACTGTT GAGGCTCCTG GAGATCCTCA AGAACCCCAG 420 AATAATGCCC ACAGGGACAA AGAAGGGGAT GACCAGAGTC ATTGGCGCTA TGGAGGCGAC 480 CCGCCCTGGC CCCGGGTGTC CCCAGCCTGC GCGGGCCGCT TCCAGTCCCC GGTGGATATC 540 CGCCCCCAGC TCGCCGCCTT CTGCCCGGCC CTGCGCCCCC TGGAACTCCT GGGCTTCCAG 600 CTCCCGCCGC TCCCAGAACT GCGCCTGCGC AACAATGGCC ACAGTGTGCA ACTGACCCTG 660 CCTCCTGGGC TAGAGATGGC TCTGGGTCCC GGGCGGGAGT ACCGGGCTCT GCAGCTGCAT 720 CTGCACTGGG GGGCTGCAGG TCGTCCGGGC TCGGAGCACA CTGTGGAAGG CCACCGTTTC 780 CCTGCCGAGA TCCACGTGGT TCACCTCAGC ACCGCCTTTG CCAGAGTTGA CGAGGCCTTG 840 GGGCGCCCGG GAGGCCTGGC CGTGTTGGCC GCCTTTCTGG AGGAGGGCCC GGAAGAAAAC 900 AGTGCCTATG AGCAGTTGCT GTCTCGCTTG GAAGAAATCG CTGAGGAAGG CTCAGAGACT 960 CAGGTCCCAG GACTGGACAT ATCTGCACTC CTGCCCTCTG ACTTCAGCCG CTACTTCCAA 1020 TATGAGGGGT CTCTGACTAC ACCGCCCTGT GCCCAGGGTG TCATCTGGAC TGTGTTTAAC 1080 CAGACAGTGA TGCTGAGTGC TAAGCAGCTC CACACCCTCT CTGACACCCT GTGGGGACCT 1140 GGTGACTCTC GGCTACAGCT GAACTTCCGA GCGACGCAGC CTTTGAATGG GCGAGTGATT 1200 GAGGCCTCCT TCCCTGCTGG AGTGGACAGC AGTCCTCGGG CTGCTGAGCC AGTCCAGCTG 1260 AATTCCTGCC TGGCTGCTGG TGACATCCTA GCCCTGGTTT TTGGCCTCCT TTTTGCTGTC 1320 ACCAGCGTCG CGTTCCTTGT GCAGATGAGA AGGCAGCACA GAAGGGGAAC CAAAGGGGGT 1380 GTGAGCTACC GCCCAGCAGA GGTAGCCGAG ACTGGAGCCT AGAGGCTGGA TCTTGGAGAA 1440 TGTGAGAAGC CAGCCAGAGG CATCTGAGGG GGAGCCGGTA ACTGTCCTGT CCTGCTCATT 1500 ATGCCACTTC CTTTTAACTG CCAAGAAATT TTTTAAAATA AATATTTATA AT 1552 Seq ID NO : 70 DNA Sequence Nucleic Acid Accession # : Nom 003039. 1 Coding sequence : 107.. 1612 1 11 21 31 41 51 ( CTTCTCTCTC CATTCAGTGC ACGCGTTACT TTGGCTAAAA GGAGGTGAGC GGCACTCTGC 60 CCTTCCAGAG CAAGCATGGA GCAACAGGAT CAGAGCATGA AGGAAGGGAG GCTGACGCTT 120 GTGCTTGCCC TGGCAACCCT GATAGCTGCC TTTGGGTCAT CCTTCCAGTA TGGGTACAAC 180 GTGGCTGCTG TCAACTCCCC AGCACTGCTC ATGCAACAAT TTTACAATGA GACTTACTAT 240 GGTAGGACCG GTGAATTCAT GGAAGACTTC CCCTTGACGT TGCTGTGGTC TGTAACCGTG 300 TCCATGTTTC CATTTGGAGG GTTTATCGGA TCCCTCCTGG TCGGCCCCTT GGTGAATAAA 360 TTTGGCAGAA AAGGGGCCTT GCTGTTCAAC AACATATTTT CTATCGTGCC TGCGATCTTA 420 ATGGGATGCA GCAGAGTCGC CACATCATTT GAGCTTATCA TTATTTCCAG ACTTTTGGTG 480 GGAATATGTG CAGGTGTATC TTCCAACGTG GTCCCCATGT ACTTAGGGGA GCTGGCCCCT 540 AAAAACCTGC GGGGGGCTCT CGGGGTGGTG CCCCAGCTCT TCATCACTGT TGGCATCCTT 600 GTGGCCCAGA TCTTTGGTCT TCGGAATCTC CTTGCAAACG TAGATGGCTG GCCGATCCTG 660 CTGGGGCTGA CCGGGGTCCC CGCGGCGCTG CAGCTCCTTC TGCTGCCCTT CTTCCCCGAG 720 AGCCCCAGGT ACCTGCTGAT TCAGAAGAAA GACGAAGCGG CCGCCAAGAA AGCCCTACAG 780 ACGCTGCGCG GCTGGGACTC TGTGGACAGG GAGGTGGCCG AGATCCGGCA GGAGGATGAG 840 GCAGAGAAGG CCGCGGGCTT CATCTCCGTG CTGAAGCTGT TCCGGATGCG CTCGCTGCGC 900 TGGCAGCTGC TGTCCATCAT CGTCCTCATG GGCGGCCAGC AGCTGTCGGG CGTCAACGCT 960 ATCTACTACT ACGCGGACCA GATCTACCTG AGCGCCGGCG TGCCGGAGGA GCACGTGCAG 1020 TACGTGACGG CCGGCACCGG GGCCGTGAAC GTGGTCATGA CCTTCTGCGC CGTGTTCGTG 1080 GTGGAGCTCC TGGGTCGGAG GCTGCTGCTG CTGCTGGGCT TCTCCATCTG CCTCATAGCC 1140 TGCTGCGTGC TCACTGCAGC TCTGGCACTG CAGGACACAG TGTCCTGGAT GCCATACATC 1200 AGCATCGTCT GTGTCATCTC CTACGTCATA GGACATGCCC TCGGGCCCAG TCCCATACCC 1260 GCGCTGCTCA TCACTGAGAT CTTCCTGCAG TCCTCTCGGC CATCTGCCTT CATGGTGGGG 1320 GGCAGTGTGC ACTGGCTCTC CAACTTCACC GTGGGCTTGA TCTTCCCGTT CATCCAGGAG 1380 GGCCTCGGCC CGTACAGCTT CATTGTCTTC GCCGTGATCT GCCTCCTCAC CACCATCTAC 1440 ATCTTCTTGA TTGTCCCGGA GACCAAGGCC AAGACGTTCA TAGAGATCAA CCAGATTTTC 1500 ACCAAGATGA ATAAGGTGTC TGAAGTGTAC CCGGAAAAGG AGGAACTGAA AGAGCTTCCA 1560 CCTGTCACTT CGGAACAGTG ACTCTGGAGA GGAAGCCAGT GGAGCTGGTC TGCCAGGGGC 1620 TTCCCACTTT GGCTTATTTT TCTGACTTCT AGCTGTCTGT GAATATCCAG AAATAAAACA 1680 ACTCTGATGT GGAATGCAGT CCTCATCTCC AGCCTCCCCA CCCCAGTGGG AACTGTGCAA 1740 AGGGCTGCCT TGCTGTTCTT GAAGCTGGGC TGTCTCTCTC CATGTTGGCC TGTCACCAGA 1800 CCCGAGTCAA TTAAACAGCT GGTCCTCCAC TTTGCTGGTT CAGCCTTCGT GTGGCTCCTG 1860 GTAACGTGGC TCCACCTTGA TGGGTCAACC TTTGTGTGGC TCCTGGTAAC ATAACAACAA 1920 CAGTTACTAT AGTGGTGAGA TGGAAGGAAT CAAATTTTGC CAGAGAAACT AACTCGGTGG 1980 CCCCAACAGG TCTTCCGGGG CCATGGGCAT TTGTTTAGAG CCAAATTCAT CCTCTTACCA 2040 GATCCTTTTC CAGAAATACC TGTCTAGGAA GGTGTGATGT CAGAAACAAT GACATCCAGA 2100 AAGCTGAGGA ACAGGTTCCT GTGGAGACAC TGAGTCAGAA TTCTTCATCC AAATTATTTT 2160 GTTAGTGGAA AATGGAATTG CTTCTGTGTA GTCAATAAAA TGAACCTGAT CACTTTTC 2218 Seq ID NO : 71 DNA Sequence Nucleic Acid Accession # : Nom 001252. 1 Coding sequence : 138.. 719 1 11 21 31 41 51 GGCTGGTCCC CTGACAGGTT GAAGCAAGTA GACGCCCAGG AGCCCCGGGA GGGGGCTGCA 60 GTTTCCTTCC TTCCTTCTCG GCAGCGCTCC GCGCCCCCAT CGCCCCTCCT GCGCTAGCGG 120 AGGTGATCGC CGCGGCGATG CCGGAGGAGG GTTCGGGCTG CTCGGTGCGG CGCAGGCCCT 180 ATGGGTGCGT CCTGCGGGCT GCTTTGGTCC CATTGGTCGC GGGCTTGGTG ATCTGCCTCG 240

TGGTGTGCAT CCAGCGCTTC GCACAGGCTC AGCAGCAGCT GCCGCTCGAG TCACTTGGGT 300 GGGACGTAGC TGAGCTGCAG CTGAATCACA CAGGACCTCA GCAGGACCCC AGGCTATACT 360 GGCAGGGGGG CCCAGCACTG GGCCGCTCCT TCCTGCATGG ACCAGAGCTG GACAAGGGGC 420 AGCTACGTAT CCATCGTGAT GGCATCTACA TGGTACACAT CCAGGTGACG CTGGCCATCT 480 GCTCCTCCAC GACGGCCTCC AGGCACCACC CCACCACCCT GGCCGTGGGA ATCTGCTCTC 540 CCGCCTCCCG TAGCATCAGC CTGCTGCGTC TCAGCTTCCA CCAAGGTTGT ACCATTGCCT 600 CCCAGCGCCT GACGCCCCTG GCCCGAGGGG ACACACTCTG CACCAACCTC ACTGGGACAC 660 TTTTGCCTTC CCGAAACACT GATGAGACCT TCTTTGGAGT GCAGTGGGTG CGCCCCTGAC 720 CACTGCTGCT GATTAGGGTT TTTTAAATTT TATTTTATTT TATTTAAGTT CAAGAGAAAA 780 AGTGTACACA CAGGGGCCAC CCGGGGTTGG GGTGGGAGTG TGGTGGGGGG TAGTGGTGGC 840 AGGACAAGAG AAGGCATTGA GCTTTTTCTT TCATTTTCCT ATTAAAAA 888 Seq ID NO : 72 DNA Sequence Nucleic Acid Accession # : NM 018092. 2 Coding sequence : 13.. 618 1 11 21 31 41 51 AGCAGGTTTC GAATGCTCTT TACTTCCTTT GTGGAGCAAA AGAAAAAAGC AGGAGTATTT 60 GAACAAATCA CTAAGACTCA TGGAACAATT ATTGGCATTA CTTCAGGGAT TGTCTTGGTC 120 CTTCTCATTA TTTCTATTTT AGTACAAGTG AAACAGCCTC GAAAAAAGGT CATGGCTTGC 180 AAAACCGCTT TTAATAAAAC CGGGTTCCAA GAAGTGTTTG ATCCTCCTCA TTATGAACTG 240 TTTTCACTAA GGGACAAAGA GATTTCTGCA GACCTGGCAG ACTTGTCGGA AGAATTGGAC 300 AACTACCAGA GGATGCGGCG CTCCTCCACC GCCTCCCGCT GCATCCACGA CCACCACTGT 360 GGGTCGCAGG CCTCCAGCGT CAAACAAAGC AGGACCAACC TCAGTTCCAT GGAGCTTCCT 420 CTCCGAAATG ACTTTGCACA ACCACAGCCA ATGAAAACAT TTAATAGCAC CTTCAAGAAA 480 AGTAGTTACA CTTTCAAACA GGGACATGAG TGCCCTGAGC AGGCCCTGGA AGACCGAGTA 540 ATGGAGGAGA TTCCCTGTGA AATTTATGTC AGGGGGCGAG AAGATTCTGC ACAAGCATCC 600 ATATCCATTG ACTTCTAATC TTCTGCTAAT GGTGATGTGA ATTCTTAGGG TGTGTACGTA 660 CGCAGCCTCC AGGGCACCAT ACTGTTTCCA GCAGCCAACC CTTTTCTCCC ATCACAACTA 720 CGAAGACCTT GATTTACCGT TAACCTATTG TATGGTGATG TTTTTATTCT CTCAGGCAGT 780 CTATATATGT TAAACCAATC AAGGAACTTA CTCTATTCAG TGGAAACAAT AATCATCTCT 840 ATTGCTTGGT GTCATTTATA GGAAGCACTG CCAGTTAAAG AGCATTAGAA GAGGTGGTTG 900 GATGGAGCCA GGCTCAGGCT GCCTCTTCGT TTTAGCAACA AGAAGACTGC TCTTGACTGA 960 TAACAGCTCT GTCAATATTT TGATGCCACA ATAAACTTGA TTTTTCTTTA CATTCCTTTT 1020 ATTTTTCCTT TCTCTAAATT TAATTTGTTT TATAAGCCTA TCGTTTTACC ATTTCATTTT 1080 CTTACATAAG TACAAGTGGT TAATGTACCA CATACTTCAG TATAGGCATT TGTTCTTGAG 1140 TGTGTCAAAA TACAGCTAGT TACTGTGCCA ATTAAGACCC AGTTGTATTT CACCCATCTG 1200 TTTCTTCTTG GCTAATCTCT GTACTTCTGC CTTTTAATTA CTGGGCCCTT ATTCCTTATT 1260 TTCTGTGAGA AATAATAGAT GATATGATTT ATTACCTTTC AATTATATTT TTCTCAGTTA 1320 TACTAGAAAA TTTCATAATC CTGGGATATA TGTACCATTG TCAGCTATGA CTAAAAATTT 1380 GAAAAAGATA AAAATTTCTA GCAAGCCTTT GAAGTTTACC AAGTATAGTC ACATTCAGTG 1440 ACAGCCCATT CATTCCAGTA AAGAATCATT TCATTCACTT TGGGAGAGGC CTATAATTAC 1500 ATTTATTTGC AATGTTTCTC TTCGCTAGAT TGTTACATAG CTCCCATTCT GTTGGTTTTG 1560 CTTACAGCAT ATGGTAACCA AGGTTAGATG CCAGTTAAAA TTCCTTAGAA ATTGGATGAG 1620 CCTTGAGATT GCTTCTTAAC TGGGACATGA CATTTTTCTA GCTCTTATCA AGAATAACAA 1680 CTTCCACTTT TTTTTAAACT GCACTTTTGA CTTTTTTTAT GGTATAAAAA CAATAATTTA 1740 TAAACATAAA AGCTCATTGT GTTTTTTAGA CTTTTGATAT TATTTGATAC TGTACAAACT 1800 TTATTAAATC AAGATGAAAG ACCTACAGGA CAGATTCCTT TCAGTGTTCA CATCAGTGGC 1860 TTTGTATGCA AATATGCTGT GTTGGACCTG GACGCTATAA CTTATTGTAA AGACCTTGGA 1920 AATGTGGACA TAAGCTCTTT CTTTCCTTTT GTTACTGTAT TTAGTTTGTG ATAAATTTTT 1980 CACTGTGTGA TATTTATGCT CTAAATCACT ACACAAATCC CATATTAAAA TATACATTGT 2040 ACCTGACCCT TTAATCATGT TATTTATGCC ACCAAGGTTG TGGATCTTAA GGTATGTATG 2100 GAAAGGAACT CATTTATCAA ATTGTAAGTA ATACAGACAT GCCATTTAAA AGAGGTAAAT 2160 TCTTGTTTTC TATATTTTGT TAGTAAATTC TCAATGAAAT AAGTTGAAGT TTCACTGGAT 2220 TTCATTAACT TTTAAATATT ACATATATGT GTTTTCTCAG ATTAGTGAAA ATTGTGACCT 2280 TAAATTTAAT ACACATATAC TGCCTCAG 2308 Seq ID NO : 73 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 ( GCTGAATGTT TTTTTCATTT TCCTGAGAGA TGCAAATGTT CATTCATTCA TCTCATTATA 60 CAACACAGTA CATAAATGTA GCTTCAGAGC GTATTAAGTG CTTTTATACA CAAGTGCTGG 120 CTGTGTGGAC CAGGTGGTAG CTCATTTAGG CCCCAAATTC ATTAAGGGCA GGGTCTGACT 180 CTTAGGCTTC TTAATATTTG GTTTGGTGCA TGGTCAAGAG CTGGACCCAC ATGTTGCATA 240 GCAGCAGGGC TGATATGTTT AAAGACGCTG GGCTTTTTCT GCTCTGGGGC CCTTTCCCGG 300 GGGTTCCGGT GAGTCCCTCC CCAGGTGGGT CTGCCCCCAC CCGTGTGGGC GGGATTAGCT 360 CCCAGAGGCT GGCCAGGCCC CACCTGGGGG AGGCTTGAGG GCAGGGCCCC AAGGCTGAGA 420 TTCAGGCTTG GGGGAACAGA GCAGGAAAGA GACCCGGTAC CGAAAGTGAG CGGGGCAGGC 480 ACCTAGTCAC ATGGGTAATG GGCAGGGGTC GGTCACTGGC TTTGGCTCCA GGGCCAGAGC 540 AGTCTGACTT AGTGTTGAGC TCCAAGCATG GAACACTGGA GTTGGTTCAT TTTGACCAGC 600 AAGCCTCTAA ATGGGTGCCT TGATTACCCA CCGCAAGGAG AGGGCAGTTG CCTTTTTATG 660 ACATGTTAAT TCCAGCCAGG TGAGTCACCA GGTAGCTCTC ATCCTCCTGC CAGGCTCCCC 720 TGCCTGTCGG TTTGGCATTG TCAGATAATG TGATCATTCA TTGAAGTGAC ATTTGAGTTC 780 CAAACCAGTT TTCTCCTTTA ACCATTTCAC CCTCAGGAGT GATTCTCCTT TGTTTGGCAT 840 TGTCAGGGAA TGTGATGATC CATTCAAATG ACTTTTGAGT TCCAAATAGT GTTTCTACTT 900 TAACTTCCTA AATGAAAAAA AAAAAAAAAA AAA 933 Seq ID NO : 74 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 ( TTTTTTTTTT TCATTTAGGA AGTTAAAGTA GAAACACTAT TTGGAACTCA AAAGTCATTT 60 GAATGGATCA TCACATTCCC TGACAATGCC AAACAAAGGA GAATCACTCC TGAGGGTGAA 120

ATGGTTAAAG GAGAAAACTG GTTTGGAACT CAAATGTCAC TTCAATGAAT GATCACATTA 180 TCTGACAATG CCAAACCGAC AGGCAGGGGA GCCTGGCAGG AGGATGAGAG CTACCTGGTG 240 ACTCACCTGG CTGGAATTAA CATGTCATAA AAAGGCAACT GCCCTCTCCT TGCGGTGGGT 300 AATCAAGGCA CCCATTTAGA GGCTTGCTGG TCAAAATGAA CCAACTCCAG TGTTCCATGC 360 TTGGAGCTCA ACACTAAGTC AGACTGCTCT GGCCCTGGAG CCAAAGCCAG TGACCGACCC 420 CTGCCCATTA CCCATGTGAC TAGGTGCCTG CCCCGCTCAC TTTCGGTACC GGGTCTCTTT 480 CCTGCTCTGT TCCCCCAAGC CTGAATCTCA GCCTTGGGGC CCTGCCCTCA AGCCTCCCCC 540 AGGTGGGGCC TGGCCAGCCT C 561 Seq ID NO : 75 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 1.. 459 1 11 21 31 41 51 ATCATTGCAG CCACGATTAA TAATGCCAGC ATGACfTCCC CAATTGACAA TGCTGGACTT 60 GCAGCAGATG ACTTCAAAAT GAATGCATCC TTGCAGACAC AGATCTCCAC GGATGCTGAA 120 GCAGTTAGCT CGGCCAAGAG TGAGATAATG GAGCTGAAAC AAGTCCTCCA GTCCCTCCAG 180 CATGAACTGC AGTCTGTCTT GGCCATGCAA AGCTCCCCAG AAGGAACCCT GGCTGACACA 240 GAAGCTGGCT ACGTGGCTCA GCTGTCAGAA ATTAAGATGT ATATCAGCAT CCTGGAGGAG 300 CAGATCTGCC AGATCCGGGG CGAGACTGAA TACCAGAACA CAGAGTATGC ACAACTGCAG 360 GACATCAAGA CACGCCTGGA GGTGGAGATC GAGACCTACC ACCGCCTGCT CGGTGGAGAG 420 GGAGGTTCTG AGGCCAGAGA AGCTGAATCT AAAGGATGAT TCTCTGTGGA CTCCAAAGGA 480 ATAACCAACA CAGCTCAATC GAGGGGAAGA GTCGCTTTTT AAAATTCACA TAAAAGCAGA 540 GGAACCAGGC TGGTGACGGA TAATGACCAA CTAATTTCAT CTCAACACTG TTTCTGATGT 600 AAAATTCAAG AGTAAGATGC AGGCAGCTGA GTCCTGTCCC CAGGATGTAA ATGATGACAC 660 CTAACAAAGG CGTGCTGAAG CACTGCAACA AACCTGCGGC CACAGAGCTG CAGCTACTCC 720 TGTAATCCTT TCTCAGATTC TTTTGTCTTA TTGGTTCGGT TTTGTCTTTA AATTGCAAAA 780 TGTGTTTTCC TTCTTAATCA TTCTGTGTCG ATAAACTTTT TGCCTGTTGC AAATCAA 837 Seq ID NO : 76 DNA Sequence Nucleic Acid Accession # : NM 003265. 2 Coding sequence : 102.. 2816 1 11 21 31 41 51 CACTTTCGAG AGTGCCGTCT ATTTGCCACA CACTTCCCTG ATGAAATGTC TGGATTTGGA 60 CTAAAGAAAA AAGGAAAGGC TAGCAGTCAT CCAACAGAAT CATGAGACAG ACTTTGCCTT 120 GTATCTACTT TTGGGGGGGC CTTTTGCCCT TTGGGATGCT GTGTGCATCC TCCACCACCA 180 AGTGCACTGT TAGCCATGAA GTTGCTGACT GCAGCCACCT GAAGTTGACT CAGGTACCCG 240 ATGATCTACC CACAAACATA ACAGTGTTGA ACCTTACCCA TAATCAACTC AGAAGATTAC 300 CAGCCGCCAA CTTCACAAGG TATAGCCAGC TAACTAGCTT GGATGTAGGA TTTAACACCA 360 TCTCAAAACT GGAGCCAGAA TTGTGCCAGA AACTTCCCAT GTTAAAAGTT TTGAACCTCC 420 AGCACAATGA GCTATCTCAA CTTTCTGATA AAACCTTTGC CTTCTGCACG AATTTGACTG 480 AACTCCATCT CATGTCCAAC TCAATCCAGA AAATTAAAAA TAATCCCTTT GTCAAGCAGA 540 AGAATTTAAT CACATTAGAT CTGTCTCATA ATGGCTTGTC ATCTACAAAA TTAGGAACTC 600 AGGTTCAGCT GGAAAATCTC CAAGAGCTTC TATTATCAAA CAATAAAATT CAAGCGCTAA 660 AAAGTGAAGA ACTGGATATC TTTGCCAATT CATCTTTAAA AAAATTAGAG TTGTCATCGA 720 ATCAAATTAA AGAGTTTTCT CCAGGGTGTT TTCACGCAAT TGGAAGATTA TTTGGCCTCT 780 TTCTGAACAA TGTCCAGCTG GGTCCCAGCC TTACAGAGAA GCTATGTTTG GAATTAGCAA 840 ACACAAGCAT TCGGAATCTG TCTCTGAGTA ACAGCCAGCT GTCCACCACC AGCAATACAA 900 CTTTCTTGGG ACTAAAGTGG ACAAATCTCA CTATGCTCGA TCTTTCCTAC AACAACTTAA 960 ATGTGGTTGG TAACGATTCC TTTGCTTGGC TTCCACAACT AGAATATTTC TTCCTAGAGT 1020 ATAATAATAT ACAGCATTTG TTTTCTCACT CTTTGCACGG GCTTTTCAAT GTGAGGTACC 1080 TGAATTTGAA ACGGTCTTTT ACTAAACAAA GTATTTCCCT TGCCTCACTC CCCAAGATTG 1140 ATGATTTTTC TTTTCAGTGG CTAAAATGTT TGGAGCACCT TAACATGGAA GATAATGATA 1200 TTCCAGGCAT AAAAAGCAAT ATGTTCACAG GATTGATAAA CCTGAAATAC TTAAGTCTAT 1260 CCAACTCCTT TACAAGTTTG CGAACTTTGA CAAATGAAAC ATTTGTATCA CTTGCTCATT 1320 CTCCCTTACA CATACTCAAC CTAACCAAGA ATAAAATCTC AAAAATAGAG AGTGATGCTT 1380 TCTCTTGGTT GGGCCACCTA GAAGTACTTG ACCTGGGCCT TAATGAAATT GGGCAAGAAC 1440 TCACAGGCCA GGAATGGAGA GGTCTAGAAA ATATTTTCGA AATCTATCTT TCCTACAACA 1500 AGTACCTGCA GCTGACTAGG AACTCCTTTG CCTTGGTCCC AAGCCTTCAA CGACTGATGC 1560 TCCGAAGGGT GGCCCTTAAA AATGTGGATA GCTCTCCTTC ACCATTCCAG CCTCTTCGTA 1620 ACTTGACCAT TCTGGATCTA AGCAACAACA ACATAGCCAA CATAAATGAT GACATGTTGG 1680 AGGGTCTTGA GAAACTAGAA ATTCTCGATT TGCAGCATAA CAACTTAGCA CGGCTCTGGA 1740 AACACGCAAA CCCTGGTGGT CCCATTTATT TCCTAAAGGG TCTGTCTCAC CTCCACATCC 1800 TTAACTTGGA GTCCAACGGC TTTGACGAGA TCCCAGTTGA GGTCTTCAAG GATTTATTTG 1860 AACTAAAGAT CATCGATTTA GGATTGAATA ATTTAAACAC ACTTCCAGCA TCTGTCTTTA 1920 ATAATCAGGT GTCTCTAAAG TCATTGAACC TTCAGAAGAA TCTCATAACA TCCGTTGAGA 1980 AGAAGGTTTT CGGGCCAGCT TTCAGGAACC TGACTGAGTT AGATATGCGC TTTAATCCCT 2040 TTGATTGCAC GTGTGAAAGT ATTGCCTGGT TTGTTAATTG GATTAACGAG ACCCATACCA 2100 ACATCCCTGA GCTGTCAAGC CACTACCTTT GCAACACTCC ACCTCACTAT CATGGGTTCC 2160 CAGTGAGACT TTTTGATACA TCATCTTGCA AAGACAGTGC CCCCTTTGAA CTCTTTTTCA 2220 TGATCAATAC CAGTATCCTG TTGATTTTTA TCTTTATTGT ACTTCTCATC CACTTTGAGG 2280 GCTGGAGGAT ATCTTTTTAT TGGAATGTTT CAGTACATCG AGTTCTTGGT TTCAAAGAAA 2340 TAGACAGACA GACAGAACAG TTTGAATATG CAGCATATAT AATTCATGCC TATAAAGATA 2400 AGGATTGGGT CTGGGAACAT TTCTCTTCAA TGGAAAAGGA AGACCAATCT CTCAAATTTT 2460 GTCTGGAAGA AAGGGACTTT GAGGCGGGTG TTTTTGAACT AGAAGCAATT GTTAACAGCA 2520 TCAAAAGAAG CAGAAAAATT ATTTTTGTTA TAACACACCA TCTATTAAAA GACCCATTAT 2580 GCAAAAGATT CAAGGTACAT CATGCAGTTC AACAAGCTAT TGAACAAAAT CTGGATTCCA 2640 TTATATTGGT TTTCCTTGAG GAGATTCCAG ATTATAAACT GAACCATGCA CTCTGTTTGC 2700 GAAGAGGAAT GTTTAAATCT CACTGCATCT TGAACTGGCC AGTTCAGAAA GAACGGATAG 2760 GTGCCTTTCG TCATAAATTG CAAGTAGCAC TTGGATCCAA AAACTCTGTA CATTAAATTT 2820 ATTTAAATAT TCAATTAGCA AAGGAGAAAC TTTCTCAATT TAAAAAGTTC TATGGCAAAT 2880 TTAAGTTTTC CATAAAGGTG TTATAATTTG TTTATTCATA TTTGTAAATG ATTATATTCT 2940 ATCACAATTA CATCTCTTCT AGGAAAATGT GTCTCCTTAT TTCAGGCCTA TTTTTGACAA 3000

TTGACTTAAT TTTACCCAAA ATAAAACATA TAAGCACGTA AAAAAAAAAA AAAAAAA 3057 Seq ID NO : 77 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 ( ATCAAGGAGG ACAGATTTTA TATGCTTAAG ACTGGAGGGA GAGAGACCAG TTAGAAAGAC 60 TCTGGCTATA ATCCAAGCAA GCCATACTAT GGGCTGGTTT GGTGGAGGTA GAGGAATGTC 120 CAGATTGGAG AAACAGGAAG TTAAAAATGG GCAGGGCTTG CTGACTGTTT GAAACTAGGG 180 GGTGTGAAGG GAGGCAGCAC TCTAGGATAA ACACCAGACT TGCCGATTGT TTGGGAATAT 240 CCAATTCTGC TGTAGAAGAC AGGAAAACAA TAAACTCAAA AGAAGTGTTA CACATAGATA 300 ACTAAATTAG TCATCTGTAG ATAGTACAAC ATATTCGTGT GTACAGAGAT CAAAAGGGAC 360 AGAAAGACCA AGGAGGCACT AAATATTCAC GGTACCCTAA ATACGTGAGA CATGAGGCAC 420 TCAGGATGCA GGAGGTTTCA ATTTGACAGG ATGGATGCAC ACTGCATGAC CCACAGTTCA 480 GCTGGTGTGA TCATTCCACC CAACTTGCCC CCTCTCCCGT GTGTTGACCC ACCCCAGCAC 540 CTGCCTCCTG CTTCTCAGAA TGTGTTTTAC ATTTATTTAA TAAACGATGT TATTTGAGCA 600 TTTA 604 Seq ID NO : 78 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TTTTTTTTTT TTTTTTTTTA AATGCTCAAA TAACATCGTT TATTAAATAA ATGTAAAACA 60 CATTCTGAGA AGCAGGAGGC AGGTGCTGGG GTGGGTCAAC ACACGGGAGA GGGGGCAAGT 120 TGGGTGGAAT GATCGATCAC ACCAGCTGAA CTGTGGGTCA TGCAGTGTGC ATCCATCCTG 180 TCAAATTGAA ACCTCCTGCA TCCTGAGTGC CTCATGTCTC ACGTATTTAG GGTACCGTGA 240 ATATTTAGTG CCTCCTTGGT CTTTCTGTCC CTTTTGATCT CTGTACACAC GAATACGTTG 300 TACTATCTAC AGATGACTAA TTTAGTTATC TGTGTGTAAC ACTTCTTTTG AGTTTATTGT 360 TTTCCTGTCT TCTACAGCAG AATTGGATAT TCCCAAACAA TCTGCAAGTC TGGTGTTTAT 420 CCTAGAGTGC TGCCTCCCTT CACACCCCCT AGTTTCAAAC AGTCAGCAAG CCCTGCCCAT 480 TTTTAACTTC CTGGTTTCTC AATCTGGACA TTCCTCTACC TCCACCAAAC CAGCCCATAG 540 TATGGCTTGC TTGGATTATA GCCAGAGTCT TTCTAACTGG TCTCTCTCCC TCCAGTCTTA 600 AGCTTAAAAT CGTCTCCTTG ATT 623 Seq ID NO : 79 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 315.. 1416 1 11 21 31 41 51 CTTCAGATAG ATTATATCTG GAGTGAAGAA TCCTGCCACC TATGTATCTG GCATAGTATT 60 CTGTGTAGTG GGATGAGCAG AGAACAAAAA CAAAATAATC CAGTGAGAAA AGCCCGTAAA 120 TAAACTTTCA GACCAGAGAT CTATTCTCTA GCTTATTTTA AGCTCAACTT AAAAGGAAGA 180 ACTGTTCTCT GATTCTTTTC GCCTTCAATA CACTTAATGA TTTAACTCCA CCCTCCTTCA 240 AAAGAAACAG CATTTCCTAC TTTTATACTG TCTATATGAT TGATTTGCAC AGCTCATCTG 300 GCCAGAAGAG CTGAGACATC CGTTCCCCTA CAAGAAACTC TCCCCGGGTG GAACAAGATG 360 GATTATCAAG TGTCAAGTCC AATCTATGAC ATCAATTATT ATACATCGGA GCCCTGCCAA 420 AAAATCAATG TGAAGCAAAT CGCAGCCCGC CTCCTGCCTC CGCTCTACTC ACTGGTGTTC 480 ATCTTTGGTT TTGTGGGCAA CATGCTGGTC ATCCTCATCC TGATAAACTG CAAAAGGCTG 540 AAGAGCATGA CTGACATCTA CCTGCTCAAC CTGGCCATCT CTGACCTGTT TTTCCTTCTT 600 ACTGTCCCCT TCTGGGCTCA CTATGCTGCC GCCCAGTGGG ACTTTGGAAA TACAATGTGT 660 CAACTCTTGA CAGGGCTCTA TTTTATAGGC TTCTTCTCTG GAATCTTCTT CATCATCCTC 720 CTGACAATCG ATAGGTACCT GGCTGTCGTC CATGCTGTGT TTGCTTTAAA AGCCAGGACG 780 GTCACCTTTG GGGTGGTGAC AAGTGTGATC ACTTGGGTGG TGGCTGTGTT TGCGTCTCTC 840 CCAGGAATCA TCTTTACCAG ATCTCAAAAA GAAGGTCTTC ATTACACCTG CAGCTCTCAT 900 TTTCCATACA GTCAGTATCA ATTCTGGAAG AATTTCCAGA CATTAAAGAT AGTCATCTTG 960 GGGCTGGTCC TGCCGCTGCT TGTCATGGTC ATCTGCTACT CGGGAATCCT AAAAACTCTG 1020 CTTCGGTGTC GAAATGAGAA GAAGAGGCAC AGGGCTGTGA GGCTTATCTT CACCATCATG 1080 ATTGTTTATT TTCTCTTCTG GGCTCCCTAC AACATTGTCC TTCTCCTGAA CACCTTCCAG 1140 GAATTCTTTG GCCTGAATAA TTGCAGTAGC TCTAACAGGT TGGACCAAGC TATGCAGGTG 1200 ACAGAGACTC TTGGGATGAC GCACTGCTGC ATCAACCCCA TCATCTATGC CTTTGTCGGG 1260 GAGAAGTTCA GAAACTACCT CTTAGTCTTC TTCCAAAAGC ACATTGCCAA ACGCTTCTGC 1320 AAATGCTGTT CTATTTTCCA GCAAGAGGCT CCCGAGCGAG CAAGCTCAGT TTACACCCGA 1380 TCCACTGGGG AGCAGGAAAT ATCTGTGGGC TTGTGACACG GACTCAAGTG GGCTGGTGAC 1440 CCAGTCAGAG TTGTGCACAT GGCTTAGTTT TCATACACAG CCTGGGCTGG GGGTGGGGTG 1500 GGAGAGGTCT TTTTTAAAAG GAAGTTACTG TTATAGAGGG TCTAAGATTC ATCCATTTAT 1560 TTGGCATCTG TTTAAAGTAG ATTAGATCTT TTAAGCCCAT CAATTATAGA AAGCCAAATC 1620 AAAATATGTT GATGAAAAAT AGCAACCTTT TTATCTCCCC TTCACATGCA TCAAGTTATT 1680 GACAAACTCT CCCTTCACTC CGAAAGTTCC TTATGTATAT TTAAAAGAAA GCCTCAGAGA 1740 ATTGCTGATT CTTGAGTTTA GTGATCTGAA CAGAAATACC AAAATTATTT CAGAAATGTA 1800 CAACTTTTTA CCTAGTACAA GGCAACATAT AGGTTGTAAA TGTGTTTAAA ACAGGTCTTT 1860 GTCTTGCTAT GGGGAGAAAA GACATGAATA TGATTAGTAA AGAAATGACA CTTTTCATGT 1920 GTGATTTCCC CTCCAAGGTA TGGTTAATAA GTTTCACTGA CTTAGAACCA GGCGAGAGAC 1980 TTGTGGCCTG GGAGAGCTGG GGAAGCTTCT TAAATGAGAA GGAATTTGAG TTGGATCATC 2040 TATTGCTGGC AAAGACAGAA GCCTCACTGC AAGCACTGCA TGGGCAAGCT TGGCTGTAGA 2100 AGGAGACAGA GCTGGTTGGG AAGACATGGG GAGGAAGGAC AAGGCTAGAT CATGAAGAAC 2160 CTTGACGGCA TTGCTCCGTC TAAGTCATGA GCTGAGCAGG GAGATCCTGG TTGGTGTTGC 2220 AGAAGGTTTA CTCTGTGGCC AAAGGAGGGT CAGGAAGGAT GAGCATTTAG GGCAAGGAGA 2280 CCACCAACAG CCCTCAGGTC AGGGTGAGGA TGGCCTCTGC TAAGCTCAAG GCGTGAGGAT 2340 GGGAAGGAGG GAGGTATTCG TAAGGATGGG AAGGAGGGAG GTATTCGTGC AGCATATGAG 2400 GATGCAGAGT CAGCAGAACT GGGGTGGATT TGGTTTGGAA GTGAGGGTCA GAGAGGAGTC 2460 AGAGAGAATC CCTAGTCTTC AAGCAGATTG GAGAAACCCT TGAAAAGACA TCAAGCACAG 2520 AAGGAGGAGG AGGAGGTTTA GGTCAAGAAG AAGATGGATT GGTGTAAAAG GATGGGTCTG 2580 GTTTGCAGAG CTTGAACACA GTCTCACCCA GACTCCAGGC TGTCTTTCAC TGAATGCTTC 2640 TGACTTCATA GATTTCCTTC CCATCCCAGC TGAAATACTG AGGGGTCTCC AGGAGGAGAC 2700

TAGATTTATG AATACACGAG GTATGAGGTC TAGGAACATA CTTCAGCTCA CACATGAGAT 2760 CTAGGTGAGG ATTGATTACC TAGTAGTCAT TTCATGGGTT GTTGGGAGGA TTCTATGAGG 2820 CAACCACAGG CAGCATTTAG CACATACTAC ACATTCAATA AGCATCAAAC TCTTAGTTAC 2880 TCATTCAGGG ATAGCACTGA GCAAAGCATT GAGCAAAGGG GTCCCATAGA GGTGAGGGAA 2940 GCCTGAAAAA CTAAGATGCT GCCTGCCCAG TGCACACAAG TGTAGGTATC ATTTTCTGCA 3000 TTTAACCGTC AATAGGCAAA GGGGGGAAGG GACATATTCA TTTGGAAATA AGCTGCCTTG 3060 AGCCTTAAAA CCCACAAAAG TACAATTTAC CAGCCTCCGT ATTTCAGACT GAATGGGGGT 3120 GGGGGGGGCG CCTTAGGTAC TTATTCCAGA TGCCTTCTCC AGACAAACCA GAAGCAACAG 3180 AAAAAATCGT CTCTCCCTCC CTTTGAAATG AATATACCCC TTAGTGTTTG GGTATATTCA 3240 TTTCAAAGGG AGAGAGAGAG GTTTTTTTCT GTTCTTTCTC ATATGATTGT GCACATACTT 3300 GAGACTGTTT TGAATTTGGG GGATGGCTAA AACCATCATA GTACAGGTAA GGTGAGGGAA 3360 TAGTAAGTGG TGAGAACTAC TCAGGGAATG AAGGTGTCAG AATAATAAGA GGTGCTACTG 3420 ACTTTCTCAG CCTCTGAATA TGAACGGTGA GCATTGTGGC TGTCAGCAGG AAGCAACGAA 3480 GGGAAATGTC TTTCCTTTTG CTCTTAAGTT GTGGAGAGTG CAACAGTAGC ATAGGACCCT 3540 ACCCTCTGGG CCAAGTCAAA GACATTCTGA CATCTTAGTA TTTGCATATT CTTATGTATG 3600 TGAAAGTTAC AAATTGCTTG AAAGAAAATA TGCATCTAAT AAAAAACACC TTCTA 3655 Seq ID NO : 80 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 GCCCCTGAAG TTAGCGGAAG GGAACGGGCA TGTTTTGGAA AGGCCCGCCG GGAATTCCCT 60 CAGAAACCAG GCGAAGCTCC CTGCTGGGCC AGGCCCCCCT CGTGTGCTTG AGGAGGATGG 120 GAGCCCGGCC TCGGTTTGTT ATCCTAATTA AGTGGAAAAT TAAGAAAATA ATAGAATAGC 180 GTAAGTACTA ATAGTAAAAT TATAGTAAGA GAAATAACAA TAGCTAGAAT GGAATGAATT 240 GCTGTATTAA CCAAGGCTAG AAAGAATTTC AGCCCTCCGA AAGTTAAAGC GAGGGAAGAG 300 AGAGACCCTC TCATATTGTT TTATACTCAG TACCTGTTTT TTTTTTTTTT TTTTAAAAAA 360 AGGAAGTGAA ATCAAAGACA GGCAGCCCAG CGCCAGGCCC AAAACTGGAC CTGGGCCTGC 420 CTGGCCTAAA CCTAGTAGTT AAAAATCAAC TCATGACTTA GAAACCGATG TTATTCATAG 480 ATTCCAGACA TTCTATAGAA GAACATTGTG AAACTCCCTG CCCTGTTCTG TTTCTCTCTG 540 ACCATCGGTG CATGCAGCCC CTGTCACGTA CCCCTTGCTT GCTCAAATCA ATCACGACCC 600 TTTCATGTGA AATTTTAGTG TTGTGAGCTC TTAAAAGCGA CAGAAATTGT GCACTCGGGG 660 AGCTCGGATT TTAAGGCAGT AGCTTGCCAA TGCTCCCAGC TGAATAAAGC CCTTTCTTCT 720 ACAGCTCCGT GTCTGAGAGG TTTTGTCTGT GGCTTGTCCT GCTACAGTCC TTGGTTCCCT 780 GACCAGGAAG CGAGGTGACT GACAAGCCCT GTGGAGCGTC CCTGCAGAGG ACTCCGGCCA 840 GCCTGAGTGA CGCAATCCAA AGAGCGCTCC CGGGTAGGAA ATGGCCCCGG TGGAATGCCT 900 TGCCAGAGCA GCGCATAGCA GGCTCCCGAG AAGGATTAAC ACTGGCTGAA CACCGGGAAG 960 GAACTGGCAC TTGAAGTCCA GACATCTGAA GCTTGTCAAG ACTAGTCTTT GGAACTTGCC 1020 CCACTCCATG TGAGTGGAAG CATGGCCTGA TCACCCACGG TGTGCCTGTA TTGACATCTT 1080 TGTTCTGGTT TTGACTTGGC TTGACTTGGT AAGACTAGTC TTTGGAACTT GCCCCACTCC 1140 ACGTGAGTGG AAGCGTGGCC TGATCACCCA CGGTGTGCCT GTATTGGCAC TTTTGTTCTG 1200 GTTTTGACTT GGCTTGACTT GGTAAGACTA GTCTTTGGAA CTTGCCCCAC TCCATCTGAG 1260 TGGAAACGTG GCCTGATCAC CCACAGCATG CCTGCATGGG CACTCTTGTT CTGGTTTTGA 1320 CTTGACTTGA ATTGCTGGAT ACTTTGGTTT TGGTTTTGAC TTGGCTTGAA TTTTTTGGTA 1380 CTCGGATTTT GAATTTCGTG ATTTTGGTTT GGTATAAACG GTAAAAGTGT GTGTGCCCTC 1440 TTTACCTGTT CTTTGTCTTG TGGTATGTGT GGTGTGAGCG TGGTATTTTG TCTGGAAAAA 1500 AAAAAAAAAA 1510 Seq ID NO : 81 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 CGCTGCCGGG CCGGGGCTGG GCCGGAGCGG CGGCGCCTGG ATGCCGGCCC GGGGCTGGGC 60 CGGAGACTGG CGCCCGCCCC GAAGCGACTT TCGGTCCCCG ACCCGCTCCG CCTGACCCCT 120 ATGATGAAGA GGGCGTCCAC TGGAGTTCTT GCTGTCGACA TCTTTGACAA GTTCAACTTC 180 ACGGGAGCCA GAGTCCCATG GTTCGACGCC ATTCATGAAG AATTCCCCAG GGAGCTGGAG 240 TCCTCCATCT CCTTCCCAGC CAACTTCTTC AAACCACCTG AAGAAAAAGT GCTTAGGTAG 300 AGGTTGAGCA TCCTAATCCT GAAATCTGAA ATGCTCCAGA ATCTGAACCT TCTTGAGCAC 360 CAACCTGACA CTTAAAGGAA GTGCTCATTG GAGGATCTGT GACAATTACT AAAAACTTCC 420 CCAAATAAAA AGGACATGAA AAGAATCTCA CGCTATCGCC CAGGCTGGAG TGCAGTGGCG 480 CGATCTCCGC TCACTGCAAG CTCCGCCTCC CGGGTTCGCG CCATTCTCCT GCCTCAGCCT 540 CCCGAGAGTA GCTGGGACTG CAGGCGCCCG CCACCACGCC CAGCTAATTT TTTGTATTTT 600 TAGTGGAGAC GGGGTTTCAC CGTGTTGGCC AGAATGGTTT CGATCTCCTC ACCTCGCGAT 660 CCATCCGCCT CAGCCTCCCA AAGTGCTGGG ATTACAGGCG TGAGCCACCG TGCCTGGCCC 720 TCATGTGTCT TAAAAAGAGG GGTGACTCTG ATGTGGGGTC ATGCTTGAAA CTGAGAGGAC 780 GAGGTCCCCG ACCCTCCATT GCAGCCAGCT CTCTCTGGAA CTAACAGAGT GAGAACTCGC 840 TCATTACCAA GGGGAGGACA CCAAGCCATT CATGGGGGAC CCACCCCCAT GACCCAAACA 900 ACCCCGACCA CGCCCACCTC CAACCCTTAA GCAGTCCATC TCCAGAACTC TTTTCATCCT 960 GCAGATCTGA AACTCTAGCC CACAAAACAC CAACTCCACT CCCCAGCCAC TGGTGCCCAC 1020 CGTTGTTTCT GTCTCTGAAT TTGACTCCTC TAGGGACCTC CCATAAGTGG AATCATACAA 1080 TATTTGTCCT TTTGTGCTTG GCTTATTTCA CTGAGCGTAA TGTTCTCTAG GTTCACCTGT 1140 GTTGTAGCAA ACGTCAGACT TTCCCTCCTT TTGAAGGCTG AGTAATATTC TGTTGTGTGG 1200 ATGGAGCACG CATTGTTTAT CCACTCACCT GTTGACGCAT GCCTGGGTCG TTTCCACCTT 1260 TCGGCCTGTG TGAATGGTGC TGCTCTGAAC AGGGGTGAAG ACGTATCTGG GCGTCTGCTT 1320 TCAGTTCTTT TGGGTGTATA CCCAGAAGTG GGCTTGCTGG GTCACGTGGT AAATCCTGTG 1380 GTTGATTTTT TGAGGACGCA CCATACTGTT TTCGGTGGGA CATCTGTTGG GTTTTGAGAA 1440 GCACCTGCTG GCACTGAGAG CTGTCTTGGG GAACACAGGT GCTCCTGCCG GAGTCCTCAC 1500 GCTCTGCTCA CGTTGCAGAA GGCCCCCTGG TAAGGCCAGC CAGCCGGAGG ACCACCCCGC 1560 AGACCACACG CCCAGGGCCT GGCACCGAGG GGGAGGCCCC GATCAGCAGG TGAAAGCGAC 1620 ACCCTGATGA CACTGGCTAG TTCACCTTCA CTCTGGTCAT CGTTTACTGT ACCCCGGGGC 1680 AGCTCCCGCC TGAGCCCTAT GACCCCAACC GCCGCAGCCT CTGGTAAGGC CTGGGTATGG 1740 GGCACATGGA GAGGGCCCAT TCCAGAGGCT CCTAAGTCAA AAGAGATTCC ACAAGTCAAA 1800 ATCCTGATCC TGATCAAGCA CAGGCCTTCA CAGTGACATT TCACTGTGAC CCTGGCCCAG 1860 AGACAGAGAC CACTGTCCTG CAGTGTCCCT GGGAGGGAGG TTCTGGGTCT GCCACAGGAC 1920

ACCACACCCT GGAACATTGC ACACCCTTTG CCTGGCCTTT TCCCAGCGTT TCTGTCAGAA 1980 ATGCCCCCTC CCAAGCATAC ACCCCATCTT GTGCCCCGAG GGACTCGATT CTCTCCCCAC 2040 ACACCCGACC CGAGGCTGTC ATGGGTAGTG CCTGCTGCTG GCCCCAGGGT TAGGGCTGCT 2100 CAGCCAGTCC TGGCTGGAAA GGATGAATGT CCCACAAGCA GCTTTGGGGC CTGCTTGGTG 2160 GGAGCAGCCC GAGGATCCGC CCTTCGTCCT CCTGCCATTT CCCACTTCCC TGGCTCTGGG 2220 GTCCTCATGT TCACGTGGTT CTCAGTGACT GGGTGATTGA CNNNNNNNNN NNNNNNNNNN 2280 NNNNNNNGGT GTCTTTTGCT GGACATTTAA GCCATTCCTT GTGTTTCTGC CATTAGCTAT 2340 TATGGGCTGT AACATCTTTG CACCTGTGCC TTCTTTCTTT TTAAATTTCT GAAGTCCTAA 2400 TTTGACCCAA AGGTGACACA TCTCCCTGTG TGCCCTGTCA GTGATGAAAC CTGCTCTGGG 2460 GATGAAGATG CCGTGGGGCC CACAGATCCA AGCTCTCGGA GTGTGATTCT GTCTCCCCTA 2520 GAAACACATC CATGGCATGT CCTCAGGGCA TTTGTGCATG GGATTAAGCA AATGTTTCCT 2580 AATCATGTTT GTCCCTGTGC TCTGGCTTCT TGACCTCAGG CTGCCTCACT GGCCCATCAT 2640 TAATACGTCG ATGGTGAGCG CACTGGTGTA CAGCGAGGGG GCTCCACTTC CGAGCCCCCT 2700 GGAGAGGCCC GTCCTGGTGG AGTTCACCCT GCTGGAGATG GAGAAGCGAA CCAAGCCTGT 2760 CTGTGTGTTC TGGAACCATT CCCTGGCGTA AATGTGATGC CGGGAGTTCT GCATCTTCAT 2820 GTGAGGGCTT TGCCAAGACA CAGAGAACCC GCAGGGTTGT TGGCTCAGCG GCAGATCGTC 2880 CCACGGGGAC AGTCTCTTGT GGTCTGTGTC TCCCCCTTCA GCCCCCTGTG GGGCAGTTAG 2940 CCTCCTGCTC TGCTTCTGTG GGTGCATCAG AGCCCCCCCA GATGCCCACA CGCAGACGCG 3000 CACAGGCCTG CACGTGGAAA CACAGACATG CGCACACGCA GGCCCACACA CAGACGCACA 3060 CAGAGCTGCA CGTGGAGACA CGTGCGCACA CGCAGGCCCA CACGCAGGCC CACACACAGG 3120 TGCACGCGGA CCTGCACGTG GAGACACAGA TGTGTGCACA TGCAGGCCCA CACACAGGTG 3180 AGCGTGGACC TGTGTGAACA GATGCGCGCA GACCTGCACG TGGAGACACA GACATGCAGG 3240 CGCACAAAGA GATCCCTCAA GGCTGACACC CAGGAAGGGG CCTCTCACTT GTGGGACTCC 3300 CGAGATGCAG TGGCCAACAC TAGTGTAGTG CCCAGTTCAC TGCTGGATAA GACAGAGGCC 3360 TGTTCTGGTC ACACATGGGA GGCAGAACCC AGAGACTGGG CCCAGGAGCC CTTCTGCTGA 3420 CAGTGGGAAC TCCCAGCTAC GTGTGGGGGT CCCCATACCA GACAAAGGTC CCTGACCTTA 3480 GTCTTGCCCG AGAGGCCGAC ACAGCCCAGC TTTGGGGTCT GGCTTTACCC ACAAGAGGCC 3540 ACACCTTGCC ACAGCACTGT TTATCTGGCC TGTTTCAGAA GCACCGTCAG AGTGGCGAAG 3600 GCAGGAGGTG GTGCACGAGA GTCTACGTTC TAGCATCCAT TCAAGTGAGG GAAAGGCGTT 3660 TCGTACTTAG AAAAATGCAA AATTAATGAT TCTCACCCAC ACATGAGACT GTGGATTCAC 3720 CCATGTATGA GACAGTGGAT TCAGAGCCAT GCTGTGGCTC TCATCTGCTG GGAGCCAGTA 3780 GTGTTTGTGC TTTGGTTTTG TTTTTTTAGC TACATGGTTT ATGTGAGGTG CGGACTTACT 3840 TGAGTTGCTC TGTCTTTACA GGGAGCTTGC TTTTTCTCTG CTGGTTTGTT TTCACTTTTG 3900 CTGTCTCTGT TTAGAAGAAA ACATTAGAAC TGGGGTGTGG TGGAAGGATG GGAGCACAAT 3960 CTGGGAGGGG AAGACCTGCT CTCTCTCCAC ATACCAGGAG GGAGTGGCAG GAAGGGGAGA 4020 CACTGTGCCG GACTCAGGGA GTCAAGAGCG TGAGCACCCC CAGGCTTCAA TCTGCTGAAC 4080 GTTGTGCATC TGGGGGCGCC CGTGCAGCAG GAACACTCTC CCCATCACAA TTCCTCTGGG 4140 CACAGTGGAG AGCCATGAGT GGGGGCTGTC CTGGGGGCTG CGCTATGGTG AGTGAGCCCA 4200 CGCCAGGAGC CAGTTCAGCC CAGCCTCATT CTTCTCCTGC TTCTTTGCTT TCCAAGTTCT 4260 AGTTCATAAG CAACCAGCAC AGTACCTGGA ATGTAAGAGG CGCTTGGCTT ATAAAAGAGA 4320 GAAGAAAGGA ACCCCTTTCA CCACGAGGGA CGTCAGGCCC AGCTCTCTGT CCCGGGCATT 4380 CATCTTTTTT CCGGCAATTA GCTTCAGCTC TAATGACCTG CTGTCTGCTT TATGTTGCAC 4440 CTATGATTTC CAGATTGTAA AGTTTGTGGC AAATGTATTA ACGTTCACAT CCCATTTACA 4500 GATTAGCAAA CTAAGGATCT GAGAGGTTAT GTGATTTTCC CAGTCTGGCG GAGGGCAGGG 4560 CCCTGTCAGA AGCCGAGACA CACCTCGTAA CAGCTTGTTA TTTGGGGCTT CCCATCAGTG 4620 AGGCAGGAGT CATAATGGGG CCCTGGCTTC TGGGCAATTC CCATAAAACA TTGTGCCACC 4680 TGAAGATGGA AGTGTCAGAG GAAGGCGAGA TGTTATTTCT GAAAGCATCT ACCCTCAGAA 4740 AGAGACAGAG GAGTGCATCG CAGCTGTGTG AACCCGGGGT GGTGGTGGTT CCAGCAGCGG 4800 GGCACGTGGT GGACGCAAGA CGGCCCCGTT TGAGTTTTGC TGCTAGGTGA CACGTAGAAC 4860 TTGAACTTCA GAGGGTGCTC CTTGGGGGCC CTGATGAGAG AGACACAGAA GGGAAGGGAG 4920 ACTGTTCCCA TGGTCCTGCC TCTGCGGCAG CGAGCCTGCT GCTCTTGCAG CTGGGTGGCT 4980 GTTCGGTGCA GGGGGCCGGT GAGGAACACG GTGGGGAGCA GCCTGCGAGG GCGCCGGGCT 5040 TTCAGCACTC ACTATACCTG CTGTTTGGTT TGGCCAGGAT GGCCTGGGAG TCCCCAGGGC 5100 CGGGCAAAGA CTGCCCCCAA CAGACATGGG CGGAGGGAAC CGTCTCACCC CTGCCTCTTC 5160 TCCCTTCTCT ACGCAGTGTC AGTGGGACGG GAGGGTGGTC TGCCCGGGGC TTCAAGCTCC 5220 TGTCCAGGAA CCGGACCCAT GTCGTACGCC AGTGCAGCCA CACGGCCAGC TTCGAGGTGC 5280 TCATGGACGT CTCCAGGTGT GAGATGGGCA TCTTCTTGTG GCCACTATGC CCGCTGAGCC 5340 TACCCCCAAA CCTGCCCCTC CTCAAACTAA ATCTTCCATT CTAAGCACTT TGAACGAAGC 5400 AAATCAACCA ATTAAAAAAA TATATTCCAG GAAAAAAAAA AAAAAAAAAA AAAAAAAACA 5460 AAA 5463 Seq ID NO : 82 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence :.. 651 1 11 21 31 41 51 CCACAGGGGC CCCCAGGGCC ACCAGGGATC CCTGGAGCCA AGGGCGAGCT TGGATTGCCC 60 GGTGCCCCAG GAATCGATGG AGAGAAGGGC CCCAAAGGAC AGAAAGGAGA CCCAGGAGAG 120 CCTGGGCCAG CAGGACTCAA AGGGGAAGCA GGCGAGATGG GCTTGTCCGG CCTCCCGGGC 180 GCTGACGGCC TCAAGGGGGA GAAGGGGGAG TCGGCATCTG ACAGCCTACA GGAGAGCCTG 240 GCTCAGCTCA TAGTGGAGCC AGGGCCCCCT GGCCCCCCTG GCCCCCCAGG CCCGATGGGC 300 CTCCAGGGAA TCCAGGGTCC CAAGGGCTTG GATGGAGCAA AGGGAGAGAA GGGTGCGTCG 360 GGTGAGAGAG GCCCCAGCGG CCTGCCTGGG CCAGTTGGCC CACCGGGCCT TATTGGGCTG 420 CCAGGAACCA AAGGAGAGAA GGGCAGACCC GGGGAGCCAG GACTAGATGG TTTCCCTGGA 480 CCCCGAGGAG AGAAAGGTGA TCGGAGCGAG CGTGGAGAGA AGGGAGAACG AGGGGTCCCC 540 GGCCGGAAAG GAGTGAAGGG CCAGAAGGGC GAGCCGGGAC CACCAGGCCT GGACCAGCCG 600 TGTCCCGTGG GCCCCGACGG GCTGCCTGTG CCTGGCTGCT GGCATAAGTG ACCCACAGGC 660 CCAGCTCACA CCTGTACAGA TCCGTGTGGA CATTTTTAAT TTTTGTAAAA ACAAAACAGT 720 AATATATTGA TCTTTTTTCA TGGAATGCGC TACCTGTGGC CTTTTAACAT TCAAGAGTAT 780 GCCCACCCAG CCCCAAAGCC ACCGGCATGT GAAGCTGCCG GAAAGTGGAC AGGCCAGACC 840 AGGGAGATGT GTACCTGAGG GGCACCCTTG GGCCTGGGCT TTCCCAGGAA GGAGATGAAG 900 GTAGAAGCAC CTGGCTCGGG CAAGGCTAGA AAGATGCTAC GTTGGGCCTT CAGTCACCTG 960 ATCAGCAGAG AGACTCTCAG CTGTGGTACT GCCCTGTAAG AACCTGCCCC CGCAAAACTC 1020 TGGAGTCCCT GGGACACACC CTATCCAAGA AGACCCAGGG GTGGAACAGC GGCTGCTGTT 1080

GCTCCTGGCC TCATCAGCCT CCAAACTCAA CCACAACCAG CTGCCTCTGC AGTTGGACAA 1140 GACTTGGCCC CCGGACAAGA CTCGCCCAGC ACTTGCGGCT GGGCCCGGGG AGCAGTGAGT 1200 GGAAATCCCC CACGAGGGTC TAGCTCTACC ACATTCAGGA GGCCTCAGGA GGCCAGCCTG 1260 CCATGAGAGC ACATGTCCTC TGGCCAGGAG TAGTGGCTGA GCTCTGTGAT CGCTGTGATG 1320 TGGACCCAGC TCCAGGGAGC AGAGTGTCGA GGATGGAGGG GCCCAGCCTG GACTGACTGC 1380 TACTTCCTGT CTCTGTTTCC ATTATCACCC AGAGAGGGAC AAGATAGGAC ATGGCCTGGA 1440 CCAGGGAGGC AGGCCTCCCA CTCAGAGTCT GGGTCTCACT GGCCCCAAGT CTCCCACCCA 1500 GAACTCTGGC CAAAAATGGC TCTCTAGGTG GGCTGTGCAG GCAAAGCAAA GCTCAGGGCT 1560 GGTTCCCAGC TGGCCTGAGC AGGGGGCCTG CCACCAGACC CACCCACGCT CTGACGAGAG 1620 GCTTTTCCAC CTCCAGCAAG TGTTCCCAGC AACCAGCTCC ATCCTGGCTG CTTGCCTTCC 1680 ATTTCCGTGT AGATGGAGAT CACTGTGTGT AATAAACCAC AAGTGCGTGT C 1731 Seq ID NO : 83 DNA Sequence Nucleic Acid Accession 4 : Eos sequence 1 11 21 31 41 51 CCACAGGGGC CCCCAGGGCA CCAGGGATCC CTGGAGCCAA GGGCGAGCTT GGATTGCCCG 60 GTGCCCCAGG AATCGATGGA GAGAAGGGCC CCAAAGGACA GAAAGGAGAC CCAGGAGAGC 120 CTGGGCCAGC AGGACTCAAA GGGGAAGCAG GCGAGATGGG CTTGTCCGGC CTCCCGGGCG 180 CTGACGGCCT CAAGGGGGAG AAGGGGGAGT CGGCATCTGA CAGCCTACAG GAGAGCCTGG 240 CTCAGCTCAT AGTGGAGCCA GGGCCCCCTG GCCCCCCTGG CCCCCCAGGC CCGATGGGCC 300 TCCAGGGAAT CCAGGGTCCC AAGGGCTTGG ATGGAGCAAA GGGAGAGAAG GGTGCGTCGG 360 GTGAGAGAGG CCCCAGCGGC CTGCCTGGGC CAGTTGGCCC ACCGGGCCTT ATTGGGCTGC 420 CAGGAACCAA AGGAGAGAAG GGCAGACCCG GGGAGCCAGG ACTAGATGGT TTCCCTGGAC 480 CCCGAGGAGA GAAAGGTGAT CGGAGCGAGC GTGGAGAGAA GGGAGAACGA GGGGTCCCCG 540 GCCGGAAAGG AGTGAAGGGC CAGAAGGGCG AGCCGGGACC ACCAGGCCTG GACCAGCCGT 600 GTCCCGTGGG CCCCGACGGG CTGCCTGTGC CTGGCTGCTG GCATAAGTGA CCCACAGGCC 660 CAGCTCACAC CTGTACAGAT CCGTGTGGAC ATTTTTAATT TTTGTAAAAA CAAAACAGTA 720 ATATATTGAT CTTTTTTCAT GGAATGCGCT ACCTGTGGCC TTTTAACATT CAAGAGTATG 780 CCCACCCAGC CCCAAAGCCA CCGGCATGTG AAGCTGCCGG AAAGTGGACA GGCCAGACCA 840 GGGAGATGTG TACCTGAGGG GCACCCTTGG GCCTGGGCTT TCCCAGGAAG GAGATGAAGG 900 TAGAAGCACC TGGCTCGGGC AAGGCTAGAA AGATGCTACG TTGGGCCTTC AGTCACCTGA 960 TCAGCAGAGA GACTCTCAGC TGTGGTACTG CCCTGTAAGA ACCTGCTCCC GCAAAACTCT 1020 GGAGTCCCTG GGACACACCC TATCCAAGAA GACCCAGGGG TGGAACAGCG GCTGCTGTTG 1080 CTCCTGGCCT CATCAGCCTC CAAACTCAAC CACAACCAGC TGCCTCTGCA GTTGGACAAG 1140 ACTTGGCCCC CGGACAAGAC TCGCCCAGCA CTTGCGGCTG GGCCCGGGGA GCAGTGAGTG 1200 GAAATCCCCC ACGAGGGTCT AGCTCTACCA CATTCAGGAG GCCTCAGGAG GCCAGCCTGC 1260 CATGAGAGCA CATGTCCTCT GGCCAGGAGT AGTGGCTGAG CTCTGTGATC GCTGTGATGT 1320 GGACCCAGCT CCAGGGAGCA GAGTGTCGGG GATGGAGGGG CCCAGCCTGG ACTGACTGCT 1380 ACTTCCTGTC TCTGTTTCCA TTATCACCCA GAGAGGGACA AGATAGGACA TGGCCTGGAC 1440 CAGGGAGGCA GGCCTCCCAC TCAGAGTCTG GGTCTCACTG GCCCCAAGTC TCCCACCCAG 1500 AACTCTGGCC AAAAATGGCT CTCTAGGTGG GCTGTGCAGG CAAAGCAAAG CTCAGGGCTG 1560 GTTCCCAGCT GGCCTGAGCA GGGGGCCTGC CACCAGACCC ACCCACGCTC TGACGAGAGG 1620 CTTTTCCACC TCCAGCAAGT GTTCCCAGCA ACCAGCTCCA TCCTGGCTGC TTGCCTTCCA 1680 TTTCCGTGTA GATGGAGATC ACTGTGTGTA ATAAACCACA AGTGCGTGAA AAAAAAAAAA 1740 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AG 1782 Seq ID NO : 84 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TCCCTGAAGT GGCTGCTATC CAGGATGACT GTGTTGCTGC AGTCTTTGAG TGGTTGGAGC 60 GCTGTAATGT CTATGTTAAT AGCTGGGAAA TCGCAGTAGC AGCAACCAGA CCACTCCAAT 120 GGAACAATCC AAGTTGGGGT AAGTTTGATT GAGCAAAAAA GTCATGCTGA CTGTGTGATG 180 AAGAGGCAGA ACTGGTAACA GTGACAGGCC CTGCAGTCAG CAGCTGTGGA TTTTATGTGC 240 AGGGCAGACT GATCTGGAAA ATGGGAAGAG CTGACTGCCA ATAACACCTT GGGGGGAGGT 300 TTGTTCAGTG CATCTCCCTA CTCCTTGTAT ACCTCTGATG ACATGCAGAA GCTTAGGAAA 360 TAAAACACAC TTGTAACATC ACAGGGTGCA AGTAAGTACA TGTGGATGCC AGTGTAGAGA 420 GAAGCGAAAG CTAGTTTTCA TTGCAAGAAT CCAAACAGAG TAACAGGGCT TTGTCCACTG 480 TCTCCAGTCC ATGGTTCCCT GGTGTTCCTA GAGTCCTATT AAAAAAAAAA AAAAAAAAA 539 Seq ID N0 : 85 DNA Sequence Nucleic Acid Accession # : NM 004861. 1 Coding sequence : 204.. 1475 1 11 21 31 41 51 GGCAGCCTGG GAGTTGGACG TGGCTCAGGC AGTGGGTAGA AAGGGGCAGC CAGCCACAGC 60 CCGAGGGTCT CACTGTGTCA TCCAGAGCTG GAGTGCAGCG GCACAGTCAT GGCTCACTGG 120 AACTCAGGCT CAAGCAATCC TCCCGCCTCA GCCTTCCAAG TAACTAGGAC TACAGGCATG 180 TGCCACCACG CCTGGTGTCT GAGATGCTGC CACCGCAGAA GAAGCCCTGG GAGTCCATGG 240 CTAAGGGGCT GGTGCTGGGC GCGCTCTTCA CTAGTTTCCT GCTGCTGGTG TACTCCTATG 300 CCGTGCCCCC GCTGCATGCC GGCCTGGCCT CCACGACCCC GGAGGCCGCA GCGTCCTGCT 360 CTCCACCTGC ACTCGAGCCA GAGGCAGTGA TCCGGGCCAA CGGCTCGGCG GGGGAGTGCC 420 AGCCGCGGCG CAACATCGTG TTCTTGAAGA CGCACAAGAC GGCCAGCAGC ACCCTGCTCA 480 ACATCCTGTT CCGCTTCGGC CAGAAGCACC GGCTCAAGTT CGCCTTCCCT AACGGCCGCA 540 ATGACTTCGA CTACCCGACC TTCTTCGCCC GCAGCCTGGT GCAGGACTAT CGGCCCGGGG 600 CCTGCTTCAA CATCATCTGC AACCACATGC GCTTCCACTA CGACGAGGTG CGCGGCCTGG 660 TGCCGACCAA CGCCATCTTC ATCACGGTGC TCCGCGACCC CGCCCGCTTG TTCGAGTCCT 720 CCTTCCACTA CTTCGGGCCG GTGGTGCCCC TCACGTGGAA GCTCTCGGCC GGCGACAAGC 780 TGACCGAGTT CCTGCAAGAC CCGGATCGCT ACTACGACCC CAACGGCTTC AATGCCCACT 840 ACCTCCGAAA CCTGCTCTTC TTCGACCTGG GCTATGACAA CAGCCTGGAC CCCAGCAGCC 900 CGCAGGTGCA GGAGCACATC CTGGAGGTGG AGCGTCGCTT CCACCTGGTG CTCCTTCAAG 960 AGTACTTCGA CGAGTCGCTG GTGCTGCTGA AGGACCTGCT GTGCTGGGAG CTGGAGGACG 1020 TGCTCTACTT CAAGCTCAAC GCCCGCCGCG ACTCGCCCGT GCCGCGGCTC TCGGGGGAGC 1080

TGTATGGGCG CGCCACCGCC TGGAACATGC TGGACTCCCA CCTCTACCGC CACTTCAACG 1140 CCAGCTTCTG GCGCAAGGTG GAGGCCTTCG GGCGGGAGCG CATGGCCCGC GAGGTGGCCG 1200 CCCTGCGCCA TGCCAACGAG CGCATGCGGA CCATCTGCAT CGACGGGGGC CACGCCGTGG 1260 ACGCCGCCGC CATCCAGGAC GAGGCCATGC AGCCCTGGCA GCCGCTGGGC ACCAAGTCCA 1320 TCCTGGGCTA CAACCTCAAG AAGAGCATCG GGCAGCGGCA CGCGCAGCTC TGCCGGCGCA 1380 TGCTCACGCC CGAGATCCAG TACCTGATGG ACCTCGGCGC CAACCTGTGG GTCACCAAGC 1440 TCTGGAAGTT CATTCGCGAT TTCCTGCGGT GGTGACGTCC CACCGCCCAG CGGCTTGCCT 1500 GCCTGCTCGC TCCCTGCAGA GGGGCTGAGC AGGACGCCGC TGGTGCTGGC CGCCCCCAGC 1560 CCCCTCCTGG TGCCACCTCA GACCCCGGGG TGAGGGGGGG CTCCCTGGGG GGAGGCAGCC 1620 AGCCAAGACT GGGCCCATGA ACACAGAGAG GGCCTAACCG AGATCAGTAT TTAACTAATT 1680 ATACCAGTTT TTATTAAACC CCTTTCCCTC CCCGATAAAG AATGTTCTAT TTCTGCCTCC 1740 CCTTAAAGGG GAGACCTCAG AAGTAAAGGA ATTTGATGTT GTGTTTTTGT T 1791 Seq ID NO : 86 DNA Sequence Nucleic Acid Accession # : Eos sequence Coding sequence : 337.. 1878 1 11 21 31 41 51 CTGCACAGGG AGTTTGTCTT GTGCAAACAA TTTCCAAGGC AGCGTTTTCT TCCCTGCCTG 60 GGAGTGCAGG GCTCAGCGCC TTCACTTTGG AACTGACTCA GAGACCTAAA GAAGCCCACC 120 TGGCCAGCGG GAAGGGGGGC CGCCGCCGCC TCCCGGTTTT GGGCAGCCCT GGCCAGCTCC 180 CTGTGGCCTT GGAGGACTTC CACCGGGCAG GCGTTCCCAT GATGCCAGGC TACCAGGCGC 240 GGGGGATTCC TGCAGGCCGG CGCTGCTTTT CTTAGAACCC CCTTTCTAGA AAAGTACACC 300 TGGAGGTTTT GCTTCAAAGA GAGGAGAGGC AGCAGCATGG CGAGTGTCCT GTCCCGACGC 360 CTTGGAAAGC GGTCCCTCCT GGGAGCCCGG GTGTTGGGAC CCAGTGCCTC GGAGGGGCCC 420 TCGGCTGCCC CACCCTCGGA GCCACTGCTA GAAGGGGCCG CTCCCCAGCC TTTCACCACC 480 TCTGATGACA CCCCCTGCCA GGAGCAGCCC AAGGAAGTCC TTAAGGCTCC CAGCACCTCG 540 GGCCTTCAGC AGGTGGCCTT TCAGCCTGGG CAGAAGGTTT ATGTGTGGTA CGGGGGTCAA 600 GAGTGCACAG GACTGGTGGA GCAGCACAGC TGGATGGAGG GTCAGGTGAC CGTCTGGCTG 660 CTGGAGCAGA AGCTGCAGGT CTGCTGCAGG GTGGAGGAGG TGTGGCTGGC AGAGCTGCAG 720 GGCCCCTGTC CCCAGGCACC ACCCCTGGAG CCCGGAGCCC AGGCCCTGGC CTACAGGCCC 780 GTCTCCAGGA ACATCGATGT CCCAAAGAGG AAGTCGGACG CAGTGGAAAT GGATGAGATG 840 ATGGCGGCCA TGGTGCTGAC GTCCCTGTCC TGCAGCCCTG TTGTACAGAG TCCTCCCGGG 900 ACCGAGGCCA ACTTCTCTGC TTCCCGTGCG GCCTGCGACC CATGGAAGGA GAGTGGTGAC 960 ATCTCGGACA GCGGCAGCAG CACTACCAGC GGTCACTGGA GTGGGAGCAG TGGTGTCTCC 1020 ACCCCCTCGC CCCCCCACCC CCAGGCCAGC CCCAAGTATT TGGGGGATGC TTTTGGTTCT 1080 CCCCAAACTG ATCATGGCTT TGAGACCGAT CCTGACCCTT TCCTGCTGGA CGAACCAGCT 1140 CCACGAAAAA GAAAGAACTC TGTGAAGGTG ATGTACAAGT GCCTGTGGCC AAACTGTGGC 1200 AAAGTTCTGC GCTCCATTGT GGGCATCAAA CGACACGTCA AAGCCCTCCA TCTGGGGGAC 1260 ACAGTGGACT CTGATCAGTT CAAGCGGGAG GAGGATTTCT ACTACACAGA GGTGCAGCTG 1320 AAGGAGGAAT CTGCTGCTGC TGCTGCTGCT GCTGCCGCAG GCACCCCAGT CCCTGGGACT 1380 CCCACCTCCG AGCCAGCTCC CACCCCCAGC ATGACTGGCC TGCCTCTGTC TGCTCTTCCA 1440 CCACCTCTGC ACAAAGCCCA GTCCTCCGGC CCAGAACATC CTGGCCCGGA GTCCTCCCTG 1500 CCCTCAGGGG CTCTCAGCAA GTCAGCTCCT GGGTCCTTCT GGCACATTCA GGCAGATCAT 1560 GCATACCAGG CTCTGCCATC CTTCCAGATC CCAGTCTCAC CACACATCTA CACCAGTGTC 1620 AGCTGGGCTG CTGCCCCCTC CGCCGCCTGC TCTCTCTCTC CGGTCCGGAG CCGGTCGCTA 1680 AGCTTCAGCG AGCCCCAGCA GCCAGCACCT GCGATGAAAT CTCATCTGAT CGTCACTTCT 1740 CCACCCCGGG CCCAGAGTGG TGCCAGGAAA GCCCGAGGGG AGGCTAAGAA GTGCCGCAAG 1800 GTGTATGGCA TCGAGCACCG GGACCAGTGG TGCACGGCCT GCCGGTGGAA GAAGGCCTGC 1860 CAGCGCTTTC TGGACTGAGC TGTGCTGCAG GTTCTACTCT GTTCCTGGCC CTGCCGGCAG 1920 CCACTGACAA GAGGCCAGTG TGTCACCAGC CCTCAGCAGA AACCGAAAGA GAAAGAACGG 1980 AAACACGGAG TTTGGGCTCT GTTGGCTAAG GTGTAACACT TAAAGCAATT TTCTCCCATT 2040 GTGCGAACAT TTTATTTTTT AAAAAAAAGA AACAAAAATA TTTTTCCCCC TAAAATAGGA 2100 GAGAGCCAAA ACTGACCAAG GCTATTCAGC AGTGAACCAG TGACCAAAGA ATTAATTACC 2160 CTCCGTTTCC CACATCCCCA CTCTCTAGGG GATTAGCTTG TGCGTGTCAA AAGAAGGAAC 2220 AGCTCGTTCT GCTTCCTGCT GAGTCGGTGA ATTCTTTGCT TTCTAAACTC TTCCAGAAAG 2280 GACTGTGAGC AAGATGAATT TACTTTTCTT AAAAAAAAAA AAAAAAAAAA AAAAAAAGAG 2340 TTTCTGGCTG ATGGGTGACT CAGAGTGCAG GACTGCCTGG CCGTGGGGCA GAGGGGTTTG 2400 CCCTTCTCGG AGGGTACCTC CTGTTCCCTG TCTGAGCATC CTGCATGGAA GTCAAAGGAA 2460 ATCCCTTTCT TGGTGACGAC TTAAATCTGG GTTCCCTCAG ACATTGGGTT GCACCCCAAC 2520 AAATATTAAA TGGCTTCTTC TTAAAGCCCA GAGAAAGAGG TTTTTTAAAA GACTGTCGCC 2580 AAATAGCTGA GCCAAAAGGC TGATCAGAAT TCACTTTTTG GAATGTGGCA GTTAAACACT 2640 ACCTTGATCA TTCTCTCCTC TTTCCTCGAG GAACTCCTGG AGGGTTTGAG CGTCTGGAAA 2700 CTCTCTGCTC TGACCCGAGG AAGCACCCTC CTGACGCCGC CTTCCTCCGG TTATTGAAAG 2760 GACGCCTCAG AAATGCTTTG TTTTCTTTTA CGATGTATTC AGAAGCCTTT ACTGATTAAA 2820 GTTTTCTTTT ATTTGGGTGG CCGGGAGAGA CCCAGGGAGG TTCTGGAGGT TCCTTTCTGT 2880 CTCCTGGCCC CACCAGGGAT TTCCCCATTT CTGTTTGCTG CCTGAAAGCA GGATGAGGAA 2940 GGCCAAGGAG AGTCCTTGCA CCCGTGAGCG TCAGGATGAG GAAATGACAG GAGGAAGACG 3000 TGGGTTTGGG TTAGTGGCTG CTGGCGTTTT GGCCCTTGGT GTTTCTGGAG CCTCCAGGGA 3060 TCTAGGGGAG CCTGGGCTGC GTGCATGTCG ATAAGCAGAG CTGTTCTTGG GGAGAAGGAG 3120 GGAGGTCTCG GGAGTGTAGC ACCATGCCAA CCAGCCCTGC GCGAAGACAG AGTGAGCCAC 3180 GCCCGGATGG CAGGGCATGT TTCTGTTTTG GTGTCTCACT TTCCTCCCAG CGTGACTTAT 3240 TTGGGGATTC CTCAGGGCCT ACTGGAATGT GACTGCCCAC TGCCCAGCTG CCTCGGGTAC 3300 AAGTCCTGGC CCTATGTCCC AGCTGTCAGG GGCTCAGGGA ATCCTACCCA GCCACCTGTC 3360 CTGGGATGGA GTGTCAGCAT CCACCCCTTG GTTGTCATCG AGGCCGCCCT CCCAGTCCTG 3420 GGTGAAGATA TTTGGGCCAC CAGGGCTCCC TTGGCCCCTT CACGTAGGAA ATAGACACGT 3480 GCTTTTTAAT GCAGGACACT TTGAGTGTTA CAAAATCTGT AGACCTGGCA GTAGGGTCAT 3540 GATGTTGGGA AGGGTGTAGT GCCCTAGGTT GGTGACAGAA GGGACAGACA CTTGTGCACA 3600 GGTGTCTTTG GTGATGGGGT TTTTTTTTTT ATAACTTAGT AAAAAAAAAA AAATGTATGT 3660 GGAATTCTGT CTCTTGGTAA AGCTCAAAGC CAGGCTAGCC TGAGGTGGCG CAGGGCTCTC 3720 CTTCCTGTCC CTTCGATCTC CTTGAGAATT AAGAGCTGGC AGCTGCTGAT GGTGTTTCCC 3780 AACCCCCCTC ACTTCCCAAG ACAACCCCCA GCTTCAGGTC CTCATGGGGA GGGGAGGGCA 3840 CGTTCTTGAC ACATGGGAAC TTCGCTCAGG AGGGCCTCCC CTTCCCCTCT CCCTCAGAGT 3900 TTTCACTGCC GTCTCGTCTT TAGAAAGCTG TTTGAATTCC CCCCGCCCCC AGTTTGGACC 3960

GTGTAGATAT AACTGGATAT ACGGATTTTT CTCTTTGTGC AGGCTTCTTA TGCCGTTGGT 4020 ATACAGGGCA GGAAAGAGAG GAATAAAGGG AGAGAGCAGT GTGGAAACCA CGGTGGTTTT 4080 GCTTTGTTCT TACTAGGTTT TGGTGCCACC TTCCCTGCCT GCGCTTGTGC CCCCTCTCCT 4140 CCTTGGCACT GGCGGCCTCC TTGCCTCCCT TCCACCCGTG CTGCCATCCC GTGCCTGTCG 4200 TGTTGGTTCT TCACACGTGC TCTGTTCTCG GGGTTGTTCC ATTCATGCCT TCTTGGAGGG 4260 TGAGGGTGGC TTGGGAACCG ACCCAGTGAT CATGCCTACT TTCTTCTTTG TATCTCCCTC 4320 CTTCCCAGCC CACCCGGGCA GCAGACTCTG ATGGAAGGAA GGTGCCGTAG GTGGGCTTTT 4380 AGAAACTAAC GGGACTGGTT TTCAAAGCAG TTATCTTGGG AAACTGTTTA TTCCAGCGAT 4440 GTGACTTTTT TCAGAATATT TCTTGGAATC ATATTCAGAG TCTGGGGCTG TGTGTTGAGC 4500 AGCCTTAAGG ATGCTAGACA CTCATTTAGT GCCCAGGGAG TCCAGCGAAT GACGTCTGTG 4560 GCCAAGCGAG GTCTCAGGTG CAAAGCAAAA GGACCATTTA AAGTAAAATA GCTTGGATTC 4620 AATCATGTGA CTTTTAAATT GGCTCAGAAA GCAATTTTGT AATTTCAGAG AGTGTTTTGA 4680 GCCATGGCCA CGTTGTCATT GTGAGTCTAT AGCTTGACTC CTTGGAGAAC AATATTCATT 4740 TGGTTGTGGA GACTGATTTG CTGGGAGAAA TCTGTCCTGT TACTTTCTGG TCATCCCAGG 4800 TTCTGACTTT TACCAGGGGC AAAAAAAAAA AAAGCAAGAG GGAGATAAAT CCCATCTGTG 4860 AGTTTGTCTT ATTGGCGCCT TTTTCCTCAG CTGTCTTCCA AGTATTATTT TTACTGTTAA 4920 AAAATTTTTT AAAAATGTGA AATGTAATGT TTTTACAGCA ACAATATGAA ATATA 4975 Seq ID NO : 87 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 AGTGTGAAGG GAAGGCTAAG GACGCATCGG TGCTGGAGAG TTGAGAATAT GCCTTCCCCT 60 CCACCCCCAA CCCAGTCACC TTATTTGAAA AAAAATTAAA AAACACCTTT TATTTAAAAA 120 CCTAACCCTG GAAGTTTGCT CGGGAAGGCA TTCTCTTCCT CTTCCTCCAG CTGCCTGAAA 180 ATCATATGCG TGGTTTTTCC TGTTTCCTGC TCTGTAGCTG ACATCAGGGG AGCAACGTGA 240 ACACAGGAAA ATGGAAATCA ACATTTGAAA CTTTTAAATG GAAGCTTTAT TGGGGTTCCA 300 CATATGGAAA ACTGCAAATA GCAGAAGTAT GTGACTCAAT AAATTATTCT GGAGTGACCA 360 CATCCTCTAA CTGCCTCCCA GGACAAGACG GAGAATGTGA ACAATGCTCC TGAAGGCCCC 420 TTTCCCTCAA AGAATCACTG CAATTGAAGG AAAAATGCTC CATGTCCCCT CTGCCAGTTG 480 GTGTTTATCA AAGGACAACG GAGGAAGAGA GACAAAGTGC CTGGATGTGT GTGTTAATCA 540 AGAGTTGTCA GGACCCTGCC TCTAAAAGAA AGCGCTAAAA. TGATGCTTTT GACAAGACTT 600 TTCTCAAAGT GGATGCAGTC TAAGGGTTGG AAAACAAGGC CCAATCAGGC TAGGTCTGAC 660 TTGTCGCCTG CTTTTGTAAA TAAAGTTTTA TTGGCTCACA GA 702 Seq ID NO : 88 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 AGTGTGAAGG GAAGGCTAAG GACGCATCGG TGCTGGAGAG TTGAGAATAT GCCTTCCCCT 60 CCACCCCCAA CCCAGTCACC TTATTTGAAA AAAAATTAAA AAACACCTTT TATTTAAAAA 120 CCTAACCCTG GAAGTTTGCT CGCTGCCTGA AAATCATATG CGTGGTTTTT CCTGTTTCCT 180 GCTCTGTAGC TGACATCAGG GGAGCAACGT GAACACAGGA AAATGGAAAT CAACATTTGA 240 AACTTTTAAA TGGAAGCTTT ATTGGGGTTC CACATATGGA AAACTGCAAA TAGCAGAAGT 300 ATGTGACTCA ATAAATTATT CTGGAGTGAC CACATCCTCT AACTGCCTCC CAGGACAAGA 360 CGGAGAATGT GAACAATGCT CCTGAAGGCC CCTTTCCCTC AAAGAATCAC TGCAATTGAA 420 GGAAAAATGC TCCATGTCCC CTCTGCCAGT TGGTGTTTAT CAAAGGACAA CGGAGGAAGA 480 GAGACAAAGT GCCTGGATGT GTGTGTTAAT CAAGAGTTGT CAGGACCCTG CCTCTAAAAG 540 AAAGCGCTAA AATGATGCTT TTGACAAGAC TTTTCTCAAA GTGGATGCAG TCTAAGGGTT 600 GGAAAACAAG GCCCAATCAG GCTAGGTCTG ACTTGTCGCC TGCTTTTGTA AATAAAGTTT 660 TATTGGCTCA CAGA 674 Seq ID NO : 89 DNA Sequence Nucleic Acid Accession # Eos sequence 1 11 21 31 41 51 AGTGTGAAGG GAAGGCTAAG GACGCATCGG TGCTGGAGAG TTGAGAATAT GCCTTCCCCT 60 CCACCCCCAA CCCAGTCACC TTATTTGAAA AAAAATTAAA AAACACCTTT TATTTAAAAA 120 CCTAACCCTG GAAGTTTGCT CGCTGACATC AGGGGAGCAA CGTGAACACA GGAAAATGGA 180 AATCAACATT TGAAACTTTT AAATGGAAGC TTTATTGGGG TTCCACATAT GGAAAACTGC 240 AAATAGCAGA AGTATGTGAC TCAATAAATT ATTCTGGAGT GACCACATCC TCTAACTGCC 300 TCCCAGGACA AGACGGAGAA TGTGAACAAT GCTCCTGAAG GCCCCTTTCC CTCAAAGAAT 360 CACTGCAATT GAAGGAAAAA TGCTCCATGT CCCCTCTGCC AGTTGGTGTT TATCAAAGGA 420 CAACGGAGGA AGAGAGACAA AGTGCCTGGA TGTGTGTGTT AATCAAGAGT TGTCAGGACC 480 CTGCCTCTAA AAGAAAGCGC TAAAATGATG CTTTTGACAA GACTTTTCTC AAAGTGGATG 540 CAGTCTAAGG GTTGGAAAAC AAGGCCCAAT CAGGCTAGGT CTGACTTGTC GCCTGCTTTT 600 GTAAATAAAG TTTTATTGGC TCACAGA 627 Seq ID NO : 90 DNA Sequence Nucleic Acid Accession # : AB058765. 2 Coding sequence : 400.. 3492 1 11 21 31 41 51 GGCGCGCCAG GTAAGGCAGG CGGACGCGCG GACCCCTCGG CGCAGTGCGG CCCCGAAGGC 60 GGTAGGGCGA GAAAGAGCTG GGACCCCCCC GCAACTTCGG GATCGGCTGG GTGAGGCTGG 120 GCAGGCCTGA TGCTCAGGGG TTCGTGCCGG GAAGTTCAGG TCCTCGGACA ACCTCTCTCC 180 AGCTCTCCGC CGCCGGTACC CACGGCCCAG TCTCCACCTG GGGAAACCCC CTTGGCGTGG 240 CTTGTTTCGT TACAAGTTAT CCTGGTAGAG TGGGCATGAA GGCCTCGGAG GCAACTGTGC 300 CTGCAGGTGT CCATCACCTT CAAGGACTTG GCCGTGCGGT TCTCGGAGGA GGAGTGGCGG 360 CTCCTGGAGG AGGGGCAGAG GGAGTTCTAC CGAGACGTGA TGCGGGAGAA CTACGAGACG 420 CTGGTCTCTG TGGGGACAGC TGAGCTGCTC CCCCTCTCTG CTTTCCTGTC ACCCTCAGAG 480 CCTGGAAGAG CTGTTGGGGG AGGGAGCCAC GCTGATGAGG GGCAGGAGCC TGCTGGTTGT 540 GGAGATCCCC AGGGGGGACA GCCCCGGCAC AGCCTGCACC TCACAGCCCT GGTGCAGCTG 600 GTGAAGGAGA TCCCAGAGTT CTTGTTTGGA GAAGTCAAGG GCGCTATGGA CAGCCCCGAG 660

AGCGAGAGCC GGGGAGCCAG CCTGGATGGA GAGAGAGCGA GCCCCGAGGC AGCTGCGGCA 720 AGAGAGCCCT GCCCTCTCCG AGGCCTGCTC AGCTGCCTTC CAGACGGCCC TACCAGCCAG 780 CCCCACCTGG CCACCACGCC CACCGACAGC TCGTGTTCCA GTGGCCCAAC TGGTGACGGG 840 GTCCAGGGAA GTCCTCTCCC CATCAAAACT GCCGACAAAC CGTGGCCTAC AAGGAAGGAA 900 GGCCCAGGAG CCCTGGGCGG GGAGCCCAGC CCTCCCACCC ATAGCCCCAG CAGGAGGAAG 960 AGCCACAGAG GACAGGAGAG AGGGACCTCA GAGGCCGGAA TTTCTCCTGG GAACAGCCCC 1020 TTGCAAGGCC TCATCAACTG TCTGAAGGAA ATCCTTGTGC CTGGGCCCCG GCACCCCGAG 1080 ACATCCCCAA GCTTCTTGCC ACCTCTCCCT AGCCTGGGCA CGTCCAGGCT AACCAGAGCA 1140 GACCTGGGGC CTGGGAGCCC GCCCTGGGCA GTGAAGACCG AGGCGGTTTC AGGGGATTGT 1200 CCCCTCCAGG GTCTGCTACA CTGTCTGAAG GAGCTCCCCG AGGCCCAGGA CAGGCATCCC 1260 AGTCCCTCAG GAGTGGGGAA CCGACGGCTA CAGGAGAATC CAGGAGCCTG GAAAAGGGGT 1320 TCTGGAGGGC CTGGATACCT CCTGACCCCT CCTCCCCATC CTGATCTTGG AGCTGGCGGT 1380 CTGCTCTCTG TGAAGATGGA GAACAGCTGG GTCCAGAGCC CCCCAGGACC TGCATCCTGT 1440 CAGCCTGGCA GGCAGCCCCT CAGTCCCTCA GCCACTGGAG ACACCAGAGG GGTCCCCCAA 1500 CCCAGCTGGG GCCCTGAGGC TCAAGCTGCC AGTGCCTCAA GCTCACCGCT GGAAGCCCTG 1560 GAAGCCTGTC TGAAGGGCAT TCCCCCAAAT GGGTCGTCAC CTTCCCAGCT GCCACCCACT 1620 TCTTGTTCCC AGAACCCCCA GCCAGGAGAC TCTAGGTCTC AGAAGCCTGA ACTGCAACCC 1680 CACAGATCAC ACAGTGAAGA AGCGACCAGA GAGCCTGTTC TGCCTCTGGG TCTGCAGAGC 1740 TGTGTGAGAG ATGGCCCCAG CAGGCCCCTG GCCCCCCGAG GAACCCCCAC CAGCTTCTCC 1800 TCATCCAGCA GCACCGACTG GGACCTGGAT TTTGGGAGTC CTGTGGGGAA CCAGGGGCAG 1860 CATCCTGGAA AAGGAAGCCC ACCAGGAAGC TCCCCACTGC AGGGTCTGGA GAATTGTCTC 1920 AAGGAGATAC CTGTGCCTGT GCTGCGGCCT GCCTGGCCCT GCTCCTCAGC AGCAGACAGG 1980 GGACCGAGGA GAGCAGAGCC CAGGAACTGG ACAGCAGACA AGGAAGGACT GAGGGCTGAG 2040 GCCTGCGAGT CAGCCCGTCT CGGGCAGGGT AGGGGAGAAG CGCCCACCCG GAGCCTCCAT 2100 CTGGTCAGCC CACAGGTGTT CACCTCCAGC TGCGTCCCCG CCTGCCACCA GCGGGGGTTC 2160 AAAGACCCTG GGGCCACCAG GCCAGGAGTG TGGAGGTGGC TCCCAGAGGG GTCTGCCCCC 2220 AAGCCCTCCC CGCTGCACTG CCTGGAGAGC GCCCTGAGGG GGATCTTGCC TGTAAGGCCC 2280 TTGCGCTTCG CCTGCGTGGG AGGCCCCAGC CCCAGCCCCA GCCCCGGCTC CAGCTCGAGC 2340 TTCAGCGGCT CTGAAGGAGA AGACCCGAGG CCAGAGCCTG AGCTCTGGAA GCCGCTCCCC 2400 CAGGAGAGGG ACCGCCTTCC CAGCTGTAAG CCTCCTGTCC CTCTGTCCCC ATGTCCTGGT 2460 GGGACCCCTG CTGGCAGCAG TGGCGGCAGC CCTGGTGAAG ACCCCAGGAG AACAGAGCCC 2520 AGGTACTGCA GCGGCCTCGG TGCAGGTACA GCTCAGGATC CCTGCCCGGT TTCTCAGCTG 2580 GAGAAAAGGC CCAGGGTTAG TGAAGCATCC AGAGGCCTGG AGCTTGGACA TGGAAGACCC 2640 AGAGTTGCAG CCAAGACCCA TGAGAGGCTG CTCCCCCAGG GCCCGCCTGA GCTGCCCAGT 2700 GAGTCTCCCC CTCCGGAGCT GCCCCCTCCG GAAGCTGCGC CTCCTGTGTT GCCAGCCTCC 2760 TCCCTGCAGC CGCCATGCCA CTGTGGGAAG CCCCTGCAGC AGGAGCTGCA CAGCCTCGGT 2820 GCTGCCCTTG CGGAGAAGCT GGATCGGCTC GCCACAGCGC TGGCAGGCCT GGCTCAGGAA 2880 GTGGCCACCA TGAGGACCCA GGTGAATCGG CTGGGGAGGC GCCCCCAAGG CCCTGGGCCA 2940 ATGGGCCAAG CTTCCTGGAT GTGGACCCTC CCACGGGGAC CTCGCTGGGC TCATGGCCCT 3000 GGTCACAGAC ATCTGCCCTA CTGGAGGCAG AAGGGACCCA CGAGGCCTAA ACCAAAGATC 3060 CTGCGTGGCC AGGGAGAGAG CTGCAGGGCT GGTGACCTGC AAGGACTCTC CAGAGGGACC 3120 GCTCGCCGGG CACGTCCGCT GCCTCCAGAC GCTCCCCCGG CAGAACCTCC TGGGCTCCAC 3180 TGCAGCTCTT CCCAGCAGCT GCTGTCCTCT ACACCCAGCT GCCATGCTGC GCCGCCTGCA 3240 CACCCCCTCC TCGCACATAC CGGGGGCCAC CAGAGCCCCC TTCCCCCTTT AGTGCCTGCT 3300 GCCTTACCCC TGCAGGGAGC CTCTCCTCCT GCAGCCAGTG CAGATGCAGA CGTGCCGACC 3360 TCAGGAGTGG CACCAGACGG GATCCCAGAG CGGCCCAAGG AGCCGAGCAG CCTGCTGGGA 3420 GGAGTGCAGA GGGCCCTCCA GGAAGAACTG TGGGGTGGGG AGCACAGGGA CCCGAGATGG 3480 GGGGCGCATT GATGGCATTC CTCTTCTCCA CATCTGCTCG TTCTTGCCGA GGGTGCAGTG 3540 GTGGCGTGGA AGCCCTGTCA CCCCACCCCA GGCCACCCTC TCCCAGAGGA CGCCATCTCC 3600 CTTACTGTTG CTGGGAGCCT CGCCCTTTGT CCCAACTGGG TAGAGCCCCC AGGTGCTGTT 3660 TGCTCAGGAG GCTGCTGTGG GGGTGCCTTC CTCAGCCTCT GGCCCTCTTG GCTCAGATTC 3720 AATCAAATGT TGCTTCCCTC TCCTGTCTTT CCCACTGGAG CCGCCCAAGC TTGTAGGTGG 3780 GTGGTGTGCA TAGGCCACGT GTGCCCCACA TATGCAGGGG GTGCCCCACA CAGCTAGAGC 3840 GGCCAGGAGA GCGCCTCCTA ACCACCAGCC GTTCCTGATC TCAGGAGCCT TGAAGGGCTG 3900 GGCTCTTGCC TTCCTGGAGT AAATATTGGC ACAGATTTCA TTTGAGAGAA CTCAGCCCCC 3960 TGGTCTAAGC TGGACTTACC TCTGTGGATT CTGAAATTAA AGAAGTGAGT TGCTAAGG 4018 Seq ID NO : 91 DNA Sequence Nucleic Acid Accession # : AL831935. 1 Coding sequence :.. 1854 1 11 21 31 41 51 1 1 1 1 1 1 AGCCTGCTGG TTGTGGAGAT CCCCAGGGGG GACAGCCCCG GCACAGCCTG CACCTCACAG 60 CCCTGGTGCA GCTGGTGAAG GAGATCCCAG AGTTCTTGTT TGGAGAAGTC AAGGGCGCTA 120 TGGACAGCCC CGAGAGCGAG AGCCGGGGAG CCAGCCTGGA TGGAGAGAGA GCGAGCCCCG 180 AGGCTGCGGC AAGAGAGCCC TGCCCTCTCC GAGGCCTGCT CAGCTGCCTT CCAGACGGCC 240 CTACCAGCCA GCCCCACCTG GCCACCACGC CCACCGACAG CTCGTGTTCC AGTGGCCCAA 300 CTGGTGACGG GGTCCAGGGA AGTCCTCTCC CCATCAAAAC TGCCGACAAA CCGTGGCCTA 360 CAAGGAAGGA AGGCCCAGGA GCCCTGGGCG GGGAGCCCAG CCCTCCCACC CATAGCCCCA 420 GCAGGAGGAA GAGCCACAGA GGACAGGAGA GAGGGACCTC AGAGGCCGGA ATTTCTCCTG 480 GGAACAGCCC CTTGCAAGGC CTCATCAACT GTCTGAAGGA AATCCTTGTG CCTGGGCCCC 540 GGCACCCCGA GACATCCCCA AGCTTCTTGC CACCTCTCCC TAGCCTGGGC ACGTCCAGGC 600 TAACCAGAGC AGACCTGGGG CCTGGGAGCC CGCCCTGGGC AGTGAAGACC GAGGCGGTTT 660 CAGGGGATTG TCCCCTCCAG GGTCTGCTAC ACTGTCTGAA GGAGCTCCCC GAGGCCCAGG 720 ACAGGCATCC CAGTCCCTCA GGAGTGGGGA ACCGACGGCT ACAGGAGAAT CCAGGAGCCT 780 GGAAAAGGGG TTCTGGAGGG CCTGGATACC TCCTGACCCC TCCTCCCCAT CCTGATCTTG 840 GAGCTGGCGG TCTGCTCTCT GTGAAGATGG AGAACAGCTG GGTCCAGAGC CCCCCAGGAC 900 CTGCATCCTG TCAGCCTGGC AGGCAGCCCC TCAGTCCCTC AGCCACTGGA GACACCAGAG 960 GGGTCCCCCA ACCCAGCTGG GGCCCTGAGG CTCAAGCTGC CAGTGCCTCA AGCTCACCGC 1020 TGGAAGCCCT GGAAGCCTGT CTGAAGGGCA TTCCCCCAAA TGGGTCGTCA CCTTCCCAGC 1080 TGCCACCCAC TTCTTGTTCC CAGAACCCCC AGCCAGGAGA CTCTAGGTCT CAGAAGCCTG 1140 AACTGCAACC CCACAGATCA CACAGTGAAG AAGCGACCAG AGAGCCTGTT CTGCCTCTGG 1200 GTCTGCAGAG CTGTGTGAGA GATGGCCCCA GCAGGCCCCT GGCCCCCCGA GGAACCCCCA 1260 CCAGCTTCTC CTCATCCAGC AGCACCGACT GGGACCTGGA TTTTGGGAGT CCTGTGGGGA 1320

ACCAGGGGCA GCATCCTGGA AAAGGAAGCC CACCAGGAAG CTCCCCACTG CAGGGTCTGG 1380 AGAATTGTCT CAAGGAGATA CCTGTGCCTG TGCTGCGGCC TGCCTGGCCC TGCTCCTCAG 1440 CAGCAGACAG GGGACCGAGG AGAGCAGAGC CCAGGAACTG GACAGCAGAC AAGGAAGGGT 1500 CTGCCCCCAA GCCCTCCCCG CTGCACTGCC TGGAGAGCGC CCTGAGGGGG ATCTTGCCTG 1560 TAAGGCCCTT GCGCTTCGCC TGCGTGGGAG GCCCCAGCCC CAGCCCCAGC CCCGGCTCCA 1620 GCTCGAGCTT CAGCGGCTCT GAAGGAGAAG ACCCGAGGCC AGAGCCTGAT CTCTGGAAGC 1680 CGCTCCCCCA GGAGAGGGAC CGCCTTCCCA GCTGTAAGCC TCCTGTCCCT CTGTCCCCAT 1740 GTCCTGGTGG GACCCCTGCT GGCAGCAGTG GCGGCAGCCC TGGTGAAGAC CCCAGGAGAA 1800 CAGAGCCCAG GTACTGCAGC GGCCTCGGTG CAGGTGAGCC TGGGGTCTCC TGAGGGGGCG 1860 CCCATGCGTT CCCCAGAGGA CCAGGAGTCC AGACTGGATC CTTTGAGTCC TGCCTGTCGC 1920 TTTGCCTGGC TCTTGCCAGG GAGTCCTGCA CATTGGCCGT GCTTTAGTTC CCTGTAAGGT 1980 ACAGCTCAGG ATCCCTGCCC GGTTTCTCAG CTGGAGAAAA GGCCCAGGGT TAGTGAAGCA 2040 TCCAGAGGCC TGGAGCTTGG ACATGGAAGA CCCAGAGTTG CAGCCAAGAC CCATGAGAGG 2100 CTGCTCCCCC AGGGCCCGCC TGAGCTGCCC AGTGAGTCTC CCCCTCCGGA GCTGCCCCCT 2160 CCGGAAGCTG CGCCTCCTGT GTTGCCAGCC TCCTCCCTGC AGCCGCCATG CCACTGTGGG 2220 AAGCCCCTGC AGCAGGAGCT GCACAGCCTC GGTGCTGCCC TTGCGGAGAA GCTGGATCGG 2280 CTCGCCACAG CGCTGGCAGG CCTGGCTCAG GAAGTGGCCA CCATGAGGAC CCAGGTGAAT 2340 CGGCTGGGGA GGCGCCCCCA AGGCCCTGGG CCAATGGGCC AAGCTTCCTG GATGTGGACC 2400 CTCCCACGGG GACCTCGCTG GGCTCATGGC CCTGGTCACA GACATCTGCC CTACTGGAGG 2460 CAGAAGGGAC CCACGAGGCC TAAACCAAAG ATCCTGCGTG GCCAGGGAGA GAGCTGCAGG 2520 GCTGGTGACC TGCAAGGACT CTCCAGAGGG ACCGCTCGCC GGGCACGTCC GCTGCCTCCA 2580 GACGCTCCCC CGGCAGAACC TCCTGGGCTC CACTGCAGCT CTTCCCAGCA GCTGCTGTCC 2640 TCTACACCCA GCTGCCATGC TGCGCCGCCT GCACACCCCC TCCTCGCACA TACCGGGGGC 2700 CACCAGAGCC CCCTTCCCCC TTTAGTGCCT GCTGCCTTAC CCCTGCAGGG AGCCTCTCCT 2760 CCTGCAGCCA GTGCAGATGC AGACGTGCCG ACCTCAGGAG TGGCACCAGA CGGGATCCCA 2820 GAGCGGCCCA AGGAGCCGAG CAGCCTGCTG GGAGGAGTGC AGAGGGCCCT CCAGGAAGAA 2880 CTGTGGGGTG GGGAGCACAG GGACCCGAGA TGGGGGGCGC ATTGATGGCA TTCCTCTTCT 2940 CCACATCTGC TCGTTCTTGC CGAGGGTGCA GTGGTGGCGT GGAAGCCCTG TCACCCCACC 3000 CCAGGCCACC CTCTCCCAGA GGACGCCATC TCCCTTACTG TTGCTGGGAG CCTCGCCCTT 3060 TGTCCCAACT GGGTAGAGCC CCCAGGTGCT GTTTGCTCAG GAGGCTGCTG TGGGGGTGCT 3120 TTCCTCAGCC TCTGGCCCTC TTGGCTCAGA TTCAATCAAA TGTTGCTTCC CTCTCCTGTC 3180 TTTCCCACTG GAGCCGCCCA AGCTTGTAGG TGGGTGGTGT GCATAGGCCA CGTGTGCCCC 3240 ACATATGCAG GGGGTGCCCC ACACAGCTAG AGCGGCCAGG AGAGCGCCTC CTAACCACCA 3300 GCCGTTCCTG ATCTCAGGAG CCTTGAAGGG CTGGGCTCTT GCCTTCCTGG AGTAAATATT 3360 GGCACAGATT TCATTTGAGA GAACTCAGCC CCCTGGTCTA AGCTGGACTT ACCTCTGTGG 3420 ATTCTGAAAT TAAAGAAGTG AGTTGCCAAA AAAAAAAAAA AAAA 3464 Seq ID NO : 92 DNA Sequence Nucleic Acid Accession # : BC029071. 1 Coding sequence :.. 771 1 11 21 31 41 51 CGGACGCGTG GGCGGACGCG TGGGCGGCTG AGGAGTGGGG TGATGATGCC ACTGGCAGAA 60 GCAGGCGCCC TGGCCCAAGG AGGAGGCCCT TCAGCAACGG AGTGGGCCTG CATTCTGCGG 120 AGGAAGACCC CCAGGCACAA GCAGCCCACC TTACTGATGG TCAGAGCATC CAGAAGAAGT 180 GGCAAGACTT CAGCTGTCCT CAAAGCAGGA AGACAGAGTG TTTCTGGCAG AAAGAACAGC 240 ACAAGCAAAG ATCTGGTAAC CCTAGGTGCC TCCAGTTTGA GGGAGGAGAG AGGACACCCC 300 CTCCACCCCA GACATAGGAA AGCAGTCCAC CTGCGCACCA GGGGCAGGAC ACGTGGCTGG 360 GTGCAGACGC TGGCCCGGAT GTCGCGGAGG ACTCGCGGGC CGGTAGAGCG CGCGGCGGCG 420 GCGGCGGCGG CGGCGGCGGG AGGAGACGCA GGTCACGCCC CCTTCCCACC ACCTCCCGCC 480 GCCGACGGGG CGCGCGCGCC GAGGAGCCCG GGACAGGTGA CTCCTAGAGG ACTGCGTCTG 540 CGCCTCCCCC GGCGGGAGTC CCTTCTTCGC GGCCTCTGCC GCCCCCTGCG TCCCCTCCTG 600 GGCTTCCGAG AGTCTGACTC AGCCAAGCCG GCATCGCTTC GCCTCCTACA ACACACCCCG 660 AGCGCGAGAA GAAATTACAG GATTGCAGGG GCACGGCTAA TGCGCTCTAA TTACCCACCG 720 CCGCTGTCAT CCGCGGCGCT CCGCGGCGCT GGGCCAACGC GCCGTAATTA AGACGCCGCT 780 CCCCGGTCCC GGAACCCTCC CTTCGCCACC CTCCACCCAC CCACCTCGCG GTCCCCAGGA 840 CCACTGGCTG CCAACTCCTG CCGCCCTCTG GGACTGCCCC TCAGTCCCAG GAGAGCTATG 900 AGGCCTCACT GGGGGCAGAA CTTGGGGAGA CCGAAGCCGG CCCTTCCACT CCCCTAAACC 960 TACAGTCCTG GAAGGTCTCT GCTGGAAGAG ACTGGGAGAG TGGGGAGGGG CCAGGGACCT 1020 ATTTCGTTGA CAGAAACAGT GAGGTCTATT GGAAAGTTAG CCTTCAGTGG GAGGAGTGGC 1080 AAAGGCACGC AGGGCAGCAG TACCCCCGTT TGGCACTTGA GGCACGGAGA AGGGAAGGGA 1140 AGTCCGCCCA GCCAGAACTC CCAGACCCGC TCGTTTAACA GTGGCTTTAT GAGCAGCACG 1200 ACGGACTCCC TCCCCTGGCG GGGAAATTAC CTTCCTGCGA AGAAAGGTGA CATCCCCGCC 1260 ACAGACACGG AGGCCCCGCC TGCTGGCCAG CTGTGGCCGC CATAGGGGAG CTGGTGAGGA 1320 GTGAGGTGGC TCTGGCCTCC CATGTCAGGT AGGGTGAGAG AGGCCCTGAA GATAGAAGCC 1380 AGGCCCGAAG GCCAGAATTA AAGGGGTAGC TTGGCCATCA GCTCCTTCCC CCAAAACCAG 1440 GCTCAGAGCT CTCCTCTATC AGCAATTCTT TCCTGAGGTC CAGGGTGTTG CAAACTCATG 1500 GCCTTGGGCC ACGTTTTACC TTCAGTGAGG TTTTGTTTGG CTTGCAATGA GTACATGGGT 1560 TTTAGGTTGA ATGTGAGAGT CTGCAGACAA TGTGGGTTCT CCGACTGCCC TCCCAGTGAA 1620 GGTGGACCTC TGATTTAGAC CGGCCCGCTG GGCCCGTGCC TACATCCTTT TCCTCAGCGT 1680 CAGGATCTTA GTCCCCATGA TTGCTGCCCC TTTGTGGTCT GCATGTTTCT TGGTAAGGGT 1740 GCCCAGTCAA GTGTCTCTGG GAGCCCCCTC TTCTCTGTCA TCGTCAGGCT CCCCACTTGC 1800 AGTGGCCGTG GTGGCTGCAC ATGCTCCCGG ATACCCCTCC AGCACTCCCT TTTGTCATCT 1860 TGAGTTTCAG TCCGTGACTT GGGTGGCACC CTATCTTCTC CATCAGGGAT GGTAGCTATT 1920 TTTCTGCCAT GAGACTAGAG GTTGCTTGAG AACAGGAAAT TGGATCTCTC CCTTCAGGCT 1980 GGGATTTCAC TAAGGGCTGG AGAAGGGGGG AATATGGGAG GATTATCTCC TATCACAGGG 2040 AGCGCTCTGA GGGCAAGGCT GTGTCTCCGA TTCAGACTGA CGGTTCCCTG AGGATGGGGC 2100 TGTTTCTCCC CTCCGACTGG GGCTCCCTGA GGATGGGGCT GTTTCTCCCC TCCGACTGGG 2160 GCTCCCTGAG GACAGGGCTG TGTCTCCCCT CAGCCTGGGG CTCCCTGAGT CAGGGCTGTG 2220 TCTCCCCTCA GACTGGGGCT CCCTGAGGAC GGGGCTGTGT CTGCCTCAGA CTGGGAATCC 2280 CTGAAGATGG GGCCGTGTCT CCCTCAAAGT GGGGCTCCCT CAGGACAGCG TTGTGTCTCC 2340 CCTCAGACTG CGGCTCCCTG AGGACGGGGC TGTGTCTCCC TCAGACTGGG GCTCCCTGAA 2400 GAAAGGGCTG CTTCTCCCTC AGACTGGAGC TCCCTGAAGA TGGGGCTGTG TCCCCCTCAG 2460 ACTGGGGCTG CCTGAGGACG AGGCTGCATC TCCCCTCAGA CTGGAGCTCC CTGAGGGCAG 2520

GGCTGTCTCC CCCCTTCAGA CTGGGGCCTC CCCCAAAGGA CAGGGACTGT GTCTCCCCTG 2580 GGACTAGGTT CTTTGTGTCT TCTGCATCAG ACAGATTCCC ATGAGGACAG GGCTGTCTCC 2640 CCCTCCATCT GGAGCTCCCT GAAGGCAATG GCCTCTCCCC TCAAATGGGA CATTTGCACC 2700 CCACCCCACC CTCTGGCTCC CCATGGCGCC CAGGCATTCC TCCCAGGACA CCATTTGTCA 2760 CGCTTTGATG AATGAAACTT ACTAAAAAAA AAAAAAAAAA 2800 Seq ID NO : 93 DNA Sequence Nucleic Acid Accession # : NM 002104. 1 Coding sequence : 41.. 835 1 11 21 31 41 51 AACACATTTC ATCTGGGCTT CTTAAATCTA AATCTTTAAA ATGACTAAGT TTTCTTCCTT 60 TTCTCTGTTT TTCCTAATAG TTGGGGCTTA TATGACTCAT GTGTGTTTCA ATATGGAAAT 120 TATTGGAGGG AAAGAAGTGT CACCTCATTC CAGGCCATTT ATGGCCTCCA TCCAGTATGG 180 CGGACATCAC GTTTGTGGAG GTGTTCTGAT TGATCCACAG TGGGTGCTGA CAGCAGCCCA 240 CTGCCAATAT CGGTTTACCA AAGGCCAGTC TCCCACTGTG GTTTTAGGCG CACACTCTCT 300 CTCAAAGAAT GAGGCCTCCA AACAAACACT GGAGATCAAA AAATTTATAC CATTCTCAAG 360 AGTTACATCA GATCCTCAAT CAAATGATAT CATGCTGGTT AAGCTTCAAA CAGCCGCAAA 420 ACTCAATAAA CATGTCAAGA TGCTCCACAT AAGATCCAAA ACCTCTCTTA GATCTGGAAC 480 CAAATGCAAG GTTACTGGCT GGGGAGCCAC CGATCCAGAT TCATTAAGAC CTTCTGACAC 540 CCTGCGAGAA GTCACTGTTA CTGTCCTAAG TCGAAAACTT TGCAACAGCC AAAGTTACTA 600 CAACGGCGAC CCTTTTATCA CCAAAGACAT GGTCTGTGCA GGAGATGCCA AAGGCCAGAA 660 GGATTCCTGT AAGGGTGACT CAGGGGGCCC CTTGATCTGT AAAGGTGTCT TCCACGCTAT 720 AGTCTCTGGA GGTCATGAAT GTGGTGTTGC CACAAAGCCT GGAATCTACA CCCTGTTAAC 780 CAAGAAATAC CAGACTTGGA TCAAAAGCAA CCTTGTCCCG CCTCATACAA ATTAAGTTAC 840 AAATAATTTT ATTGGATGCA CTTGCTTCTT TTTTCCTAAT ATGCTCGCAG GTTAGAGTTG 900 GGTGTAAGTA AAGCAGAGCA CATATGGGGT CCATTTTTGC ACTTGTAAGT CATTTTATTA 960 AGGAATCAAG TTCTTTTTCA CTTGTATCAC TGATGTATTT CTACCATGCT GGTTTTATTC 1020 TAAATAAAAT TTAGAAGACT 1040 Seq ID NO : 94 DNA Sequence Nucleic Acid Accession # : Nom 052947. 1 Coding sequence : 199.. 4794 1 11 21 31 41 51 1 1 1 1 1 1 GAATCTGCTG AGCCCCCACT AACCCAGAGT GATAAAAGAG AGACTTCTCA CACCACAGCA 60 GCAGCGACTG GTCGGAGTTC CCATGCTGAT GCAAGAGAAT GTGCTATTTC AACCCAGGCA 120 GAGCAAGAAG CAAAAACCCT TCAAACTTCA ACAGACTCAG TCTCCAAAGA AGGCAACACA 180 AATTGCAAGG GAGAAGGCAT GCAAGTTAAT ACTCTATTTG AAACAAGCCA GGTTCCAGAC 240 TGGAGTGATC CTCCTCAGGT ACAAGTTCAG GAAACAGTCA GAGAGACAAT CTCTTGCAGC 300 CAGATGCCAG CTTTCTCAGA GCCTGCTGGG GAGGAGTCCC CATTCACTGG GACCACAACA 360 ATTTCCTTCT CAAACTTAGG AGGGGTCCAC AAGGAAAATG CATCATTAGC TCAACACTCG 420 GAGGTCAAAC CCTGTACCTG TGGTCCACAG CAGGAAGAAA AACAAGACAG AGATGGCAAC 480 ATACCTGACA ATTTCAGGGA AGACCTAAAA TATGAGCAGA GCATCTCAGA AGCCAATGAT 540 GAGACTATGT CCCCAGGTGT GTTCTCAAGG CATCTCCCCA AGGATGCTCG TGCTGACTTC 600 AGGGAGCCTG TGGCTGTCTC TGTTGCTTCC CCTGAACCCA CAGATACTGC CCTCACCCTG 660 GAAAATGTGT GTGATGAGCC AAGGGACAGA GAAGCAGTGT GTGCAATGGA GTGTTTTGAG 720 GCTAGTGACC AAGGAACATG TTTTGATACC ATAGATTCTC TTGTTGGGAC ACCAGTTGAT 780 AACTATTCGC CTCAAGAAAT TTGCTCTGTA GATACGGAAC TGGCAGAAGG TCAAAACAAA 840 GTATCTGATT TATGTTCTTC TAATGACAAG ACACTGGAAG TCTTTTTTCA GACACAAGTG 900 TCTGAGACTT CAGTGTCTAC GTGCAAAAGC AGCAAGGACG GCAACTCAGT CATGTCCCCT 960 CTTTTTATCA GTACTTTCAC CTTGAACATT TCACACACAG CTAGTGAAGG TGCCACAGGA 1020 GAAAATCTAG CCAAGGTGGA GAAATCCACC TACCCACTGG CCTCCACAGT ACATGCTGGC 1080 CAGGAGCAGC CAAGCCCCAG CAACTCAGGA GGGCTTGATG AAACACAGCT CCTTTCTTCT 1140 GAGAACAATC CTTTAGTGCA ATTTAAAGAA GGAGGTGACA AGAGCCCCAG TCCTAGTGCC 1200 GCAGACACCA CAGCCACACC AGCCAGTTAT AGTTCAATTG TGAGTTTTCC TTGGGAGAAG 1260 CCAACAACAT TAACTGCTAA TAATGAGTGC TTTCAAGCGA CCAGAGAGAC TGTTACCATT 1320 GCCACCGAAG TCCACCCAGC CAAATACCTT GCTGTGTCAA TTCCTGAGGA CAAGCATGCA 1380 GGTGGCACTG AGGAGAGGTT CCCTCGTGCA TCCCATGAAA AGGTTTCCCA ATTTCCTTCC 1440 CAAGTGCAGG TGGATCATAT TTTAAGTGGT GCTACCATCA AATCTACAAA AGAGCTACTT 1500 TGCAGGGCAC CCAGTGTGCC AGGAGTCCCA CACCATGTCC TGCAGCTCCC AGAGGGAGAG 1560 GGTTTCTGCA GTAATTCCCC TCTTCAGGTT GATAACCTGT CTGGAGATAA GAGCCAGACT 1620 GTGGACAGAG CAGACTTTAG GAGCTATGAA GAGAATTTCC AAGAAAGAGG AAGTGAAACA 1680 AAGCAGGGGG TCCAGCAGCA GAGCCTGTCC CAGCAGGGTT CTCTTTCTGC ACCTGATTTC 1740 CAACAAAGTT TGCCTACGAC ATCTGCTGCA CAAGAGGAAA GAAACTTGGT GCCCACGGCC 1800 CCCTCACCAG CAAGCTCTAG GGAAGGAGCA GGGCAGCGCT CAGGTTGGGG GACGAGGGTC 1860 TCCGTGGTGG CTGAAACTGC TGGGGAAGAA GACAGTCAGG CTCTGAGCAA CGTTCCATCT 1920 CTCTCTGATA TCCTTTTGGA AGAGTCTAAA GAATATAGAC CTGGAAATTG GGAGGCAGGC 1980 AACAAGCTGA AGATTATAAC TCTAGAGGCT TCCGCTTCTG AAATCTGGCC ACCACGACAA 2040 CTGACAAATT CTGAGAGCAA GGCATCAGAC GGTGGTCTCA TAATTCCTGA CAAGGTCTGG 2100 GCTGTACCTG ATAGTCTAAA GGCAGATGCT GTTGTGCCTG AATTGGCCCC CTCTGAAATA 2160 GCAGCATTGG CTCACAGTCC AGAGGATGCT GAGTCAGCCC TTGCTGATAG CAGAGAAAGC 2220 CATAAAGGCG AAGAGCCCAC CATCAGTGTA CACTGGAGAA GTCTTTCTTC CCGGGGTTTC 2280 AGCCAACCGA GACTCCTGGA GTCATCCGTG GACCCTGTAG ATGAAAAGGA GTTATCTGTC 2340 ACAGATTCAC TGTCAGCGGC TTCTGAAACT GGAGGGAAGG AAAATGTTAA CAATGTGAGT 2400 CAAGACCAGG AGGAAAAACA ACTCAAGATG GATCACACTG CCTTCTTTAA AAAGTTTCTG 2460 ACCTGCCCTA AAATCCTAGA GTCCTCTGTA GATCCCATTG ATGAGATAAG TGTGATAGAG 2520 TACACCAGGG CTGGAAAACC AGAGCCCTCT GAAACCACAC CACAGGGCGC CAGAGAAGGA 2580 GGTCAATCAA ATGACGGAAA CATGGGCCAC GAAGCGGAAA TCCAGTCGGC CATTTTGCAA 2640 GTTCCATGTC TCCAGGGAAC CATTCTGAGT GAAAATAGAA TCAGCAGAAG CCAAGAAGGC 2700 AGTATGAAGC AGGAGGCAGA ACAAATTCAA CCTGAGGAGG CAAAAACTGC CATTTGGCAA 2760 GTCCTGCAAC CCAGCGAAGG CGGTGAAAGA ATTCCAAGTG GATGTAGCAT AGGCCAAATA 2820 CAAGAAAGCA GTGATGGGAG CTTAGGGGAG GCTGAGCAAA GCAAAAAGGA CAAAGCAGAA 2880 TTGATTTCCC CCACTTCACC TCTTTCTAGT TGTCTTCCAA TAATGACTCA CTCTTCTCTT 2940

GGGGTTGACA CGCACAACTC CACAGGCCAA ATTCATGACG TCCCTGAAAA TGACATAGTT 3000 GAGCCCAGAA AGCGTCAGTA TGTGTTTCCT GTTTCACAGA AAAGGGGAAC TATTGAGAAT 3060 GAGCGTGGGA AACCTTTGCC CTCTTCTCCT GATCTTACCA GGTTCCCTTG TACTTCATCT 3120 CCTGAAGGAA ATGTCACAGA CTTTTTGATA AGCCACAAAA TGGAGGAACC TAAAATAGAG 3180 GTGCTTCAAA TTGGGGAAAC CAAACCCCCA AGCTCATCTA GCTCCTCAGC GAAGACCTTG 3240 GCATTTATTT CAGGAGAACG TGAGTTAGAG AAAGCCCCTA AGTTACTGCA GGATCCATGT 3300 CAAAAGGGCA CCCTGGGCTG TGCGAAAAAG TCCAGGGAGA GAGAGAAGTC CCTGGAAGCC 3360 CGAGCAGGCA AATCGCCAGG GACCCTCACA GCAGTGACGG GGTCAGAGGA GGTCAAGAGG 3420 AAGCCAGAAG CCCCAGGCAG TGGACATTTA GCTGAGGGAG TAAAGAAGAA AATTTTGTCC 3480 AGGGTGGCAG CACTGAGGCT GAAACTGGAA GAAAAGGAAA ATATCAGAAA GAACTCAGCC 3540 TTTCTTAAAA AGATGCCCAA ACTCGAAACA TCATTATCAC ACACAGAAGA GAAACAAGAC 3600 CCAAAAAAGC CATCTTGCAA AAGAGAAGGA AGAGCTCCAG TATTACTGAA AAAAATCCAA 3660 GCTGAGATGT TCCCTGAACA CTCTGGAAAT GTAAAATTAA GCTGCCAATT TGCAGAAATT 3720 CATGAAGATT CTACTATCTG CTGGACAAAA GATTCAAAGT CCATAGCCCA AGTGCAGAGA 3780 AGTGCAGGGG ACAACTCCAC TGTTTCCTTT GCCATCGTGC AAGCCAGTCC GAAGGACCAG 3840 GGACTCTATT ACTGCTGCAT CAAGAACAGC TACGGAAAAG TGACTGCTGA ATTTAACCTC 3900 ACAGCTGAAG TTCTCAAACA GCTGTCAAGT CGCCAGGATA CTAAAGGATG TGAAGAGATT 3960 GAATTCAGCC AACTCATCTT CAAAGAAGAC TTCCTCCATG ACAGCTACTT TGGGGGCCGC 4020 CTGCGTGGTC AGATCGCCAC GGAGGAGCTG CACTTTGGAG AAGGGGTTCA CCGCAAAGCC 4080 TTCCGCAGCA CAGTGATGCA CGGCCTCATG CCTGTCTTCA AACCTGGCCA TGCCTGTGTG 4140 CTTAAGGTGC ACAATGCCAT TGCCTATGGG ACCAGAAATA ATGATGAGCT CATCCAAAGG 4200 AACTACAAAC TCGCTGCCCA GGAATGCTAT GTTCAAAATA CTGCCAGGTA TTATGCCAAG 4260 ATCTACGCTG CTGAAGCACA GCCTCTGGAA GGCTTTGGAG AAGTACCTGA GATCATTCCT 4320 ATTTTTCTTA TCCATCGGCC TGAGAACAAT ATCCCGTATG CTACAGTGGA GGAGGAGCTG 4380 ATTGGAGAAT TTGTGAAGTA TTCCATCAGG GATGGGAAAG AAATAAACTT CTTGAGAAGA 4440 GAATCAGAAG CTGGTCAGAA ATGTTGCACC TTCCAGCACT GGGTGTACCA GAAAACAAGT 4500 GGCTGCCTCC TGGTGACGGA CATGCAAGGT GTAGGAATGA AGCTAACTGA CGTTGGCATA 4560 GCAACGCTGG CTAAAGGGTA CAAGGGATTT AAAGGCAACT GTTCCATGAC CTTCATTGAT 4620 CAGTTTAAAG CACTACACCA GTGTAACAAG TATTGCAAAA TGCTGGGACT GAAATCCCTT 4680 CAAAACAACA ACCAGAAACA GAAGCAGCCG AGCATTGGGA AAAGCAAAGT TCAAACAAAC 4740 TCTATGACAG TAAAGAAGGC AGGGCCTGAG ACCCCAGGCG AAAAGAAAAC CTAACGTCCC 4800 TGGGTAACCT AATGGCCACT GGCTAGCAGC ACACAATCTC GCCAGGGAAA ATCTGAGGCC 4860 ACACAGGAGA GAATATACAG CCTGCAGAGA GTGCGTGGCA ATCCTTACCC CCAGCCGACT 4920 GTGCGCCAAG ATGCTTCTAA ACCCATCACC TGCTGTCTTC ACTCAAATGA TTTCAGAACA 4980 GGATTTGCGA CCAGGTTTAT GGGGAGATTG AATCAACGAT TGGTCTCAAA GACAGGCCAT 5040 TCTTTATATA CACGTTTAGC ATTTTTACCA ACCTCACATC ATGTGTATAT TTGTGTATTT 5100 GCACATGGTT GTGCTGTCGA GGACCTGGTG CTGAGAAGAG TCTGTTCACA GCCAAAATTC 5160 TTCCCACTGT CATTCCTAAC CTGGGATTTC TAGACACATC CTGCTGTGAT GTAAACAGAA 5220 ATCACGAATT CGCTCACTGG ATCAAGTTGT TCCACTGGTG TCTAATACGC TATTGTTGCC 5280 GGAGGTGGGT TCTGTGACGT GAAGCCATTT CCCATCATTC AACAGCCAGT TACAATTTTC 5340 TGTTTAATTA AATTCATATT TAAACAAAAA AAAAA 5375 Seq ID NO : 95 DNA Sequence Nucleic Acid Accession # : NM 134421. 1 Coding sequence : 527.. 1108 1 11 21 31 41 51 AGCTTCTGCC AAGGGTGGGG GCCCACGCGG AGGCGATCCG CTCGTTCCTC CCAGGGCCAT 60 GGGGCGACGA GGAGAGCCCT GGCCTCCCCG CGACCCGCAC CGCGACCTGG GCCAGACGCG 120 CCACCTTCCC CGGTCGCGGT TTGCTTCTCT TTAAAATGAG GACAGCTCCT CCCTTGGGGG 180 CTGTGGTGAC AGGTGAAATG AGAACGCACT GAAGACAGCT CTTGGTCCAA AGCCCCGCAC 240 ACAGGGCATG GTCTAGTGGC CCAGTCAGGA CGCGGAAACA CTCCCTGGAG GTTCTGACCC 300 ACTCCCTCTC AGCCTCCGCC TGGTCTCTGG GTTGGCTGTT CCAGCTCCAA AGAGAAGGAG 360 GAACCTTTTC CTTCTGCAGC CCCTCCCCAC CAGCTCCATT CCTTAGCTGG GGTCAGACCT 420 GGGGTCCTCA CTGCAGCTGG CCTCTGGCAG CGTTCTCAGG CTAGCCCTCC CTGCTGAAAA 480 GAGAACCGTG TGGGACTCAC AGGTGTAGTC GCCGCCGCCA GCCGCCATGG GCAAACAGAA 540 CAGCAAGCTG CGGCCCGAGG TGCTGCAGGA CCTGCGGGAG AACACGGAGT TCACCGACCA 600 CGAGCTGCAG GAGTGGTACA AGGGCTTCCT CAAGGACTGC CCCACCGGCC ACCTGACCGT 660 GGACGAGTTC AAGAAGATCT ACGCCAACTT CTTCCCCTAC GGCGACGCTT CCAAGTTCGC 720 CGAGCACGTC TTCCGCACCT TCGACACCAA CGGCGACGGC ACCATCGACT TCCGGGAGTT 780 CATCATTGCG CTGAGCGTGA CCTCGCGGGG CAAGCTGGAG CAGAAGCTCA AGTGGGCCTT 840 CAGCATGTAC GACCTGGACG GCAACGGCTA CATCAGCCGC AGCGAGATGC TGGAGATCGT 900 GCAGGCCATC TACAAGATGG TGTCGTCTGT GATGAAGATG CCGGAGGATG AGTCCACCCC 960 GGAGAAGCGC ACAGACAAGA TCTTCAGGCA GATGGACACC AACAATGACG GCAAACTGTC 1020 CTTGGAAGAA TTCATCAGAG GTGCCAAGAG CGACCCCTCC ATCGTCCGCC TGCTGCAGTG 1080 CGACCCCAGC AGTGCCAGTC AGTTCTGAGC GAGCGGCCCC TGGACAGTTG CAGAGAAACA 1140 CAGGCTTGTC GTGCCGTTTA AGCTTTGCTT GCAAGAGTGG ATGCCCCGCA ATCGTTCCTG 1200 CTCTCCCGGG CCCCGGGCCT GGGGCATGCG TTGCACCTGC CCGGCCCGGT GGCTGCGCCT 1260 CCCTCCTCCA CCTGACCAAC GCGACATTCC TCCCCTCACG CCTGGCCCGG TCCCTTCCAG 1320 GGCAACTCCC AGGGATGTGG TGACATGCAG GGTTCAAGTG TTCTTGGTTC CAGGCACCTC 1380 CCGGCTCACG GGGAGCTCAG AGGTCCATGC CGAGGAGACC AGGCAGGACC TCCCGAGGCT 1440 GCGCCCCGGC CGGCCCATGC GTTTTGTGAT CCCAAGTGAC TCTGTGGGAA GGGTGGGGAC 1500 GAGGCGTCGG GAGGGTATAC AGGGAGCCCC TCCCGTGCAT GGCTGCCCCC CCGTTCATTT 1560 TCTCCACCAC AGCCGCTTGC ACGTATAGAT ACTGTGGTCC CCTTTCTTTT AATATATAAA 1620 TTATGTATGG TGAAGTGGAG TGTATTGTGT AGGTCCCGTA TTTAATGCCT CTGACTGCCT 1680 TTGAAGCGCA GCCCTCTGTG GCCCGCAGCC CCCTGAGCCT GGCTGTTGTG TGGTATTTAT 1740 GCTCTCTTTG TCTGCCTGTT TCTAAGGAAA TGCATGTGTG CCCTGAGCCG TGATGATCCT 1800 CCCATCCGTG TTGTGAGCAC AGGCATTTGT GTCTGGTCTG TCCTCCCTGT TGATTGGTCT 1860 GGCATTTCCG GTATTAAAAT GATAAAATAA ATGGCATTTT CTGAAAAAAA AAAAAAAAAA 1920 Seq ID NO : 96 DNA Sequence Nucleic Acid Accession # : NM 002149. 2 Coding sequence : 375.. 956 1 11 21 31 41 51

I I I I I I CGGCGGCGGC GGGCAGCGGA CGGGCGGACT GACGGGCGCC TCCACCTTGC TCCCTCCCTG 60 GCTGCCGGCT TCCTTTTGTC TTTCTGGGCG GCGATGAGCG CAGGGCCGGC GCAGCAGCTG 120 CGGGCGCACG GAGGCCCGCG CTGCTAGTCA CTCCTCCCGG CCTCGGCGCG CTTGTCCCGG 180 GCAGCGGCCC GGGCCCGCTG CAGCCGCCGC CGGCGCCGAA CTTGGGCTCG GGAAGCCGGC 240 GGACCGCGTC CTGCGCCGGA GCAGGGGCAT GGTCTAGTGG CCCAGTCAGG ACGCGGAAAC 300 ACTCCCTGGA GGTTCTGACC CACTCCCTCT CAGCCTCCGC CTGGTCTCTG GTGTAGTCGC 360 CGCCGCCAGC CGCCATGGGC AAACAGAACA GCAAGCTGCG GCCCGAGGTG CTGCAGGACC 420 TGCGGGAGAA CACGGAGTTC ACCGACCACG AGCTGCAGGA GTGGTACAAG GGCTTCCTCA 480 AGGACTGCCC CACCGGCCAC CTGACCGTGG ACGAGTTCAA GAAGATCTAC GCCAACTTCT 540 TCCCCTACGG CGACGCTTCC AAGTTCGCCG AGCACGTCTT CCGCACCTTC GACACCAACG 600 GCGACGGCAC CATCGACTTC CGGGAGTTCA TCATTGCGCT GAGCGTGACC TCGCGGGGCA 660 AGCTGGAGCA GAAGCTCAAG TGGGCCTTCA GCATGTACGA CCTGGACGGC AACGGCTACA 720 TCAGCCGCAG CGAGATGCTG GAGATCGTGC AGGCCATCTA CAAGATGGTG TCGTCTGTGA 780 TGAAGATGCC GGAGGATGAG TCCACCCCGG AGAAGCGCAC AGACAAGATC TTCAGGCAGA 840 TGGACACCAA CAATGACGGC AAACTGTCCT TGGAAGAATT CATCAGAGGT GCCAAGAGCG 900 ACCCCTCCAT CGTCCGCCTG CTGCAGTGCG ACCCCAGCAG TGCCAGTCAG TTCTGAGCGA 960 GCGGCCCCTG GACAGTTGCA GAGAAACACA GGCTTGTCGT GCCGTTTAAG CTTTGCTTGC 1020 AAGAGTGGAT GCCCCGCAAT CGTTCCTGCT CTCCCGGGCC CCGGGCCTGG GGCATGCGTT 1080 GCACCTGCCC GGCCCGGTGG CTGCGCCTCC CTCCTCCACC TGACCAACGC GACATTCCTC 1140 CCCTCACGCC TGGCCCGGTC CCTTCCAGGG CAACTCCCAG GGATGTGGTG ACATGCAGGG 1200 TTCAAGTGTT CTTGGTTCCA GGCACCTCCC GGCTCACGGG GAGCTCAGAG GTCCATGCCG 1260 AGGAGACCAG GCAGGACCTC CCGAGGCTGC GCCCCGGCCG GCCCATGCGT TTTGTGATCC 1320 CAAGTGACTC TGTGGGAAGG GTGGGGACGA GGCGTCGGGA GGGTATACAG GGAGCCCCTC 1380 CCGTGCATGG CTGCCCCCCC GTTCATTTTC TCCACCACAG CCGCTTGCAC GTATAGATAC 1440 TGTGGTCCCC TTTCTTTTAA TATATAAATT ATGTATGGTG AAGTGGAGTG TATTGTGTAG 1500 GTCCCGTATT TAATGCCTCT GACTGCCTTT GAAGCGCAGC CCTCTGTGGC CCGCAGCCCC 1560 CTGAGCCTGG CTGTTGTGTG GTATTTATGC TCTCTTTGTC TGCCTGTTTC TAAGGAAATG 1620 CATGTGTGCC CTGAGCCGTG ATGATCCTCC CATCCGTGTT GTGAGCACAG GCATTTGTGT 1680 CTGGTCTGTC CTCCCTGTTG ATTGGTCTGG CATTTCCGGT ATTAAAATGA TAAAATAAAT 1740 GGCATTTTCT GAAAAAAAAA AAAAAAAAA 1769 Seq ID NO : 97 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 ( GCTGACTCTG AGGACCCCGT GGACATTAAA GAAAAATGAA CAGGTTTTTC TTAAAGCACC 60 AACCTGCTCT TTAACAAAAA TTATGAAAGG TTAAAAAGAG TCTATAAAAA CTTACCTTAT 120 GGTCAAACAT GAAAAATTGG ATAAATATGT CTACAAGGTT TTATTAAAAT TAAGTTTAAC 180 ATTAATAACA CACTAATATA AAGGTAAAAT TTAGCTTATC TGGTATAAAA GTCATACAGG 240 AAGCATTAGT AAATATAAAA TAGCGTTTAG CTTTCTTTTG TCTAAAAACT AATAAAAATT 300 GGTGCTAAAG GAAGCATTCA TTTTACTAGA GGATCATAAA AGTTAAAGAC TTAAAACAAA 360 CTTTGGCAAT TAAGACAGCA TACCAAGATG CAAATGCCTG GTTGAAATGG ATCAAATATT 420 CCATCTGCAG GTTAAACAAA AGCAATTAGC ATGCTTGTGC ACATGGCAGG CCAGAGACCC 480 TGATTGTCCC CCTTCCACTA AGGTGGTCCT CCAGTCGACC AGGCATGGGC TGCATGGTAG 540 CTCTTTTCCA GGATTCTACA GCCTGGAGTA ATAAGTCATG CCAAGCTCTC TCTGCTATAT 600 CCTGAAGTCC CTGCGGGTCA GCCCCCGAGG GCCATCCAGC TTCCGTCTCC CAACACTAAG 660 TTCACTTCTT GTCTCTCATG GCAGGGAGGA GACTTAGCAT TCCTTGGAGA CCTGAAGGGA 720 TGCAGTGAGC TTAAGAATTT TCAAGAGCTT ATCAATCAGT CAGCCCTTGT TCATCCCCGA 780 GCGGATGTGT GGTGGTATTG TGGTGGACCT TTATTGGGCA CTCTGCCGAA TAACTAGAGT 840 GGCACTTGTG CTTTAGCCTA TTTGGCTATC CCTTTCACCC TGGCATTTCA TCAACCAGAG 900 GAAGGAAAAA AAAAATAATA AGACATCGTA AAGCGAGAGA AGCCCCTTAT GGGTCTTTCA 960 ACTCTCACAT CTATTTAGAT GCAATCGAAG CCCCGCAAGG AACACCAGAT CAATTTAAAG 1020 TCCGAAATCA AATAGCTACA GGATTTAAGT CAATATTTTG GTAGATGACA GTCAATAAAA 1080 ATGTAGATTA GATAAACTGC ATCTATTACA CCCAACAGCA ATGAGCTTTT CATGAGTTGA 1140 AAAAAAGAAA AACTCATGTC GGCCCCAGCC CTGAGGCTAC CTGACCTGAC AAAACTCTTT 1200 ACACTCTATG TGTCAGAAAG AGAAAAAATG GCAGTTGGAG TTTTAACCCA GACTGTAGGG 1260 CCCTGGCCAA GGCCAGTGGC CTATCTCTCA AAACAACTAG ACGGGGTTTC CAAAGGCTGG 1320 CCCCCATGTC CAAGGGCCCT GGCAGCAATA GCCCTGTTAG CACAAGAAGC AGATAAGCTA 1380 ACTCTTAGGC AAAACCTAAA CATAAAGTCC CCCCATGCTG TGGTAACTTT AATAAATACC 1440 AAAGGACATC ATTAGCTAAT GAATGCTAGA CTGACTGACT AGATACCAAA GCTTGCTCTG 1500 TGAAAATCCC TGCATAACCG TCGAAGTTTG CAACACCCTA AACCCAGCCA CCTTACTCCT 1560 GGTATCAGAG AGCCCAGTTG AACATAACTG TGTAGAGTTA TTGGACTCAG TTTATTCTAG 1620 TGGGTCCAAC TCCAAGACCA TCCTTAAACA TCAGTAGACT GGGAGCTGTA CGTGGATGGG 1680 AGCACGTTCG CCAACCCCTG CAAAGTGATT CTGAAGAAGA CGACAAGCGC TGCTCCAGTC 1740 ACACCCGGAA GCTGACTGGT CCACTCATGG CCGAGCATGA GGAAACTCAT CGCGGGACTC 1800 ATTTTCCTTA AAATTTGGAC TTGCACAGTA AGGACTTCAA CTGACCTTCC TCAGACTGAG 1860 GACTGTTCCC AGGATATACA TCAAGTCACT GAGGTAGGGA AAAAAGGTTG CTACAGTCCT 1920 ATTATTTTAT AGTTATTATG AATGCCTAGG AACTCCAAAA GGAACTTGTT TGTACAATAA 1980 CACTCAGTAC AAAGTATGTA ATCCAGGAAG TGACCAGCCT GAAGCGTGTT ATGACTCACT 2040 GTAAGCCTCC CATGATTAAG GACTGATCCT TTTCTAAGTG ACAGAAGTAG AGTAATAGCT 2100 AAAAAAAAAA AAAAAAAAGT CGAGC 2125 Seq ID NO : 98 DNA Sequence Nucleic Acid Accession # : NM_003946. 2 Coding sequence : 98.. 724 1 11 21 31 41 51 GGCACGAGGG AGAGGCAGGA GGACACCGAG TTCCCCGTGT TGGCCTCCAG GTCCTGTGCT 60 TGCGGAGCCG TCCGGCGGCT GGGATCGAGC CCCGACAATG GGCAACGCGC AGGAGCGGCC 120 GTCAGAGACT ATCGACCGCG AGCGGAAACG CCTGGTCGAG ACGCTGCAGG CGGACTCGGG 180 ACTGCTGTTG GACGCGCTGC TGGCGCGGGG CGTGCTCACC GGGCCAGAGT ACGAGGCATT 240 GGATGCACTG CCTGATGCCG AGCGCAGGGT GCGCCGCCTA CTGCTGCTGG TGCAGGGCAA 300 GGGCGAGGCC GCCTGCCAGG AGCTGCTACG CTGTGCCCAG CGTACCGCGG GCGCGCCGGA 360

CCCCGCTTGG GACTGGCAGC ACGTGGGTCC GGGCTACCGG GACCGCAGCT ATGACCCTCC 420 ATGCCCAGGC CACTGGACGC CGGAGGCACC CGGCTCGGGG ACCACATGCC CCGGGTTGCC 480 CAGAGCTTCA GACCCTGACG AGGCCGGGGG CCCTGAGGGC TCCGAGGCGG TGCAATCCGG 540 GACCCCGGAG GAGCCAGAGC CAGAGCTGGA AGCTGAGGCC TCTAAAGAGG CTGAACCGGA 600 GCCGGAGCCA GAGCCAGAGC TGGAACCCGA GGCTGAAGCA GAACCAGAGC CGGAACTGGA 660 GCCAGAACCG GACCCAGAGC CCGAGCCCGA CTTCGAGGAA AGGGACGAGT CCGAAGATTC 720 CTGAAGGCCA GAGCTCTGAC AGGCGGTGCC CCGCCCATGC TGGATAGGAC CTGGGATGCT 780 GCTGGAGCTG AATCGGATGC CACCAAGGCT CGGTCCAGCC CAGTACCGCT GGAAGTGAAT 840 AAACTCCGGA GGGTCGGACG GGACCTGGGC TCTCTCCACG ATTCTGGCTG TTTGCCCAGG 900 AACTTAGGGT GGGTACCTCT GAGTCCCAGG GACCTGGGCA GGCCCAAGCC CACCACGAGC 960 ATCATCCAGT CCTCAGCCCT AATCTGCCCT TAGGAGTCCA GGCTGCACCC TGGAGATCCC 1020 AAACCTAGCC CCCTAGTGGG ACAAGGACCT GACCCTCCTG CCCGCATACA CAACCCATTT 1080 CCCCTGGTGA GCCACTTGGC AGCATATGTA GGTACCAGCT CAACCCCACG CAAGTTCCTG 1140 AGCTGAACAT GGAGCAAGGG GAGGGTGACT TCTCTCCACA TAGGGAGGGC TTAGAGCTCA 1200 CAGCCTTGGG AAGTGAGACT AGAAGAGGGG AGCAGAAAGG GACCTTGAGT AGACAAAGGC 1260 CACACACATC ATTGTCATTA CTGTTTTAAT TGTCTGGCTT CTCTCTGGAC TGGGAGCTCA 1320 GTGAGGATTC TGACCAGTGA CTTACACAAA AGGCGCTCTA TACATATTAT AATATATTCG 1380 CTTACTAAAT GAAAAAAAAA AAAAAAAAAA A 1411 Seq ID NO : 99 DNA Sequence Nucleic Acid Accession # : NM 004207. 1 Coding sequence : 63.. 1460 1 11 21 31 41 51 ( GGCGAGAGGC GGGCTGAGGC GGCCCAGCGG CGGCAGGTGA GGCGGAACCA ACCCTCCTGG 60 CCATGGGAGG GGCCGTGGTG GACGAGGGCC CCACAGGCGT CAAGGCCCCT GACGGCGGCT 120 GGGGCTGGGC CGTGCTCTTC GGCTGTTTCG TCATCACTGG CTTCTCCTAC GCCTTCCCCA 180 AGGCCGTCAG TGTCTTCTTC AAGGAGCTCA TACAGGAGTT TGGGATCGGC TACAGCGACA 240 CAGCCTGGAT CTCCTCCATC CTGCTGGCCA TGCTCTACGG GACAGGTCCG CTCTGCAGTG 300 TGTGCGTGAA CCGCTTTGGC TGCCGGCCCG TCATGCTTGT GGGGGGTCTC TTTGCGTCGC 360 TGGGCATGGT GGCTGCGTCC TTTTGCCGGA GCATCATCCA GGTCTACCTC ACCACTGGGG 420 TCATCACGGG GTTGGGTTTG GCACTCAACT TCCAGCCCTC GCTCATCATG CTGAACCGCT 480 ACTTCAGCAA GCGGCGCCCC ATGGCCAACG GGCTGGCGGC AGCAGGTAGC CCTGTCTTCC 540 TGTGTGCCCT GAGCCCGCTG GGGCAGCTGC TGCAGGACCG CTACGGCTGG CGGGGCGGCT 600 TCCTCATCCT GGGCGGCCTG CTGCTCAACT GCTGCGTGTG TGCCGCACTC ATGAGGCCCC 660 TGGTGGTCAC GGCCCAGCCG GGCTCGGGGC CGCCGCGACC CTCCCGGCGC CTGCTAGACC 720 TGAGCGTCTT CCGGGACCGC GGCTTTGTGC TTTACGCCGT GGCCGCCTCG GTCATGGTGC 780 TGGGGCTCTT CGTCCCGCCC GTGTTCGTGG TGAGCTACGC CAAGGACCTG GGCGTGCCCG 840 ACACCAAGGC CGCCTTCCTG CTCACCATCC TGGGCTTCAT TGACATCTTC GCGCGGCCGG 900 CCGCGGGCTT CGTGGCGGGG CTTGGGAAGG TGCGGCCCTA CTCCGTCTAC CTCTTCAGCT 960 TCTCCATGTT CTTCAACGGC CTCGCGGACC TGGCGGGCTC TACGGCGGGC GACTACGGCG 1020 GCCTCGTGGT CTTCTGCATC TTCTTTGGCA TCTCCTACGG CATGGTGGGG GCCCTGCAGT 1080 TCGAGGTGCT CATGGCCATC GTGGGCACCC ACAAGTTCTC CAGTGCCATT GGCCTGGTGC 1140 TGCTGATGGA GGCGGTGGCC GTGCTCGTCG GGCCCCCTTC GGGAGGCAAA CTCCTGGATG 1200 CGACCCACGT CTACATGTAC GTGTTCATCC TGGCGGGGGC CGAGGTGCTC ACCTCCTCCC 1260 TGATTTTGCT GCTGGGCAAC TTCTTCTGCA TTAGGAAGAA GCCCAAAGAG CCACAGCCTG 1320 AGGTGGCGGC CGCGGAGGAG GAGAAGCTCC ACAAGCCTCC TGCAGACTCG GGGGTGGACT 1380 TGCGGGAGGT GGAGCATTTC CTGAAGGCTG AGCCTGAGAA AAACGGGGAG GTGGTTCACA 1440 CCCCGGAAAC AAGTGTCTGA GTGGCTGGGC GGGGCCGGCA GGCACAGGGA GGAGGTACAG 1500 AAGCCGGCAA CGCTTGCTAT TTATTTTACA AACTGGACTG GCTCAGGCAG GGCCACGGCT 1560 GGGCTCCAGC TGCCGGCCCA GCGGATCGTC GCCCGATCAG TGTTTTGAGG GGGAAGGTGG 1620 CGGGGTGGGA ACCGTGTCAT TCCAGAGTGG ATCTGCGGTG AAGCCAAGCC GCAAGGTTAC 1680 AAGGCATCCT CACCAGGGGC CCCGCCTGCT GCTCCCAGGT GGCCTGCGGC CACTGCTATG 1740 CTCAAGGACC TGGAAACCCA TGCTTCGAGA CAACGTGACT TTAATGGGAG GGTGGGTGGG 1800 CCGCAGACAG GCTGGCAGGG CAGGTGCTGC GTGGGGCCCT CTCCAGCCCG TCCTACCCTG 1860 GGCTCACATG GGGCCTGTGC CCACCCCTCT TGAGTGTCTT GGGGACAGCT CTTTCCACCC 1920 CTGGAAGATG GAAATAAACC TGCGTGTGGG TGGAGTGTTC TCGTGCCGAA TTCAAAAAGC 1980 TT 1982 Seq ID NO : 100 DNA Sequence Nucleic Acid Accession # : NM 018325. 1 Coding sequence : 163.. 1590 1 11 21 31 41 51 ACGTGGTACG GAACCGGCGC CGCGCTTGCT GCTGGTAACA GGGCCTTGCC TAGTGGGCCT 60 TCCTTCCCAG GTCGCCCCTC AGTCTCCACT AGAGACAGGA CTGACCAGTT GCTCTTCCTT 120 CCAAGAACCT TCGAGATCTG CGGTCTGGGG TCTGGTTGAA AGATGGCGGC CCTCACTACC 180 CTGTTTAAGT ACATAGATGA AAATCAGGAT CGCTACATTA AGAAACTCGC AAAATGGGTG 240 GCTATCCAGA GTGTGTCTGC GTGGCCGGAG AAGAGAGGCG AAATCAGGAG GATGATGGAA 300 GTTGCTGCTG CAGATGTTAA GCAGTTGGGG GGCTCTGTGG AACTGGTGGA TATCGGAAAA 360 CAAAAGCTCC CTGATGGCTC GGAGATCCCG CTCCCTCCTA TTCTGCTCGG CAGGCTGGGC 420 TCCGACCCAC AGAAGAAGAC CGTGTGCATT TACGGGCACC TGGATGTGCA GCCTGCAGCC 480 CTGGAGGACG GCTGGGACAG CGAGCCCTTC ACCCTGGTGG AGCGAGACGG CAAGCTGTAT 540 GGGAGAGGTT CGACTGATGA TAAGGGCCCG GTGGCCGGCT GGATAAACGC CCTGGAAGCG 600 TATCAGAAAA CAGGCCAGGA GATTCCTGTC AACGTCCGAT TCTGCCTCGA AGGCATGGAG 660 GAGTCAGGCT CTGAGGGCCT AGACGAGCTG ATTTTTGCCC GGAAAGACAC ATTCTTTAAG 720 GATGTGGACT ATGTCTGCAT TTCTGACAAT TACTGGCTGG GAAAGAAGAA GCCCTGCATC 780 ACCTACGGCC TCAGGGGCAT TTGCTACTTT TTCATCGAGG TGGAGTGCAG CAACAAAGAC 840 CTCCATTCTG GGGTGTACGG GGGCTCGGTG CATGAGGCCA TGACTGATCT CATTTTGCTG 900 ATGGGCTCTT TGGTGGACAA GAGGGGGAAC ATCCTGATCC CCGGCATTAA CGAGGCCGTG 960 GCCGCCGTCA CGGAAGAGGA GCACAAGCTG TACGACGACA TCGACTTTGA CATAGAGGAG 1020 TTTGCCAAGG ATGTGGGGGC GCAGATCCTC CTGCACAGCC ACAAGAAAGA CATCCTCATG 1080 CACCGATGGC GGTACCCGTC TCTGTCCCTC CATGGCATCG AAGGCGCCTT CTCTGGGTCT 1140 GGGGCCAAGA CCGTGATTCC CAGGAAGGTG GTTGGCAAGT TCTCCATCAG GCTCGTGCCG 1200

AACATGACTC CTGAAGTCGT CGGCGAGCAG GTCACAAGCT ACCTAACTAA GAAGTTTGCT 1260 GAACTACGCA GCCCCAATGA GTTCAAGGTG TACATGGGCC ACGGTGGGAA GCCCTGGGTC 1320 TCCGACTTCA GTCACCCTCA TTACCTGGCT GGGAGAAGAG CCATGAAGAC AGTTTTTGGT 1380 GTTGAGCCAG ACTTGACCAG GGAAGGCGGC AGTATTCCCG TGACCTTGAC CTTTCAGGAG 1440 GCCACGGGCA AGAACGTCAT GCTGCTGCCT GTGGGGTCAG CGGATGACGG AGCCCACTCC 1500 CAGAATGAAA AGCTCAACAG GTATAACTAC ATAGAGGGAA CCAAGATGCT GGCCGCGTAC 1560 CTGTATGAGG TCTCCCAGCT GAAGGACTAG GCCAAGCCCT CTGTGTGCCA TCTCCAATGA 1620 GAAGGAATCC TGCCCTCACC TCACCCTTTT CCAACTTGCC CAGGGAAGTG GAGGTTCCCT 1680 CTTTCCTTTC CCTCTTGTCA GGTCATCCAT GACTTTAGAG AACAGACACA AGTGTATCCA 1740 GCTGTCCACG GGTGGAGCTA CCCGTTGGGC TTATGAGTGA CCTGGAGTGA CAGCTGAGTC 1800 ACCCTGGGTA AGTTCTCAGA GTGGTCAGGA TGGCTTGACC TGCAGAAGAT ACCCAAGGTC 1860 CAAAAGCACA AGGTCTGCGG AAAGTTCTGG TTGTCGGCTG GGCACCACGG CTCACACCTA 1920 TAATCGAGCA CTTTGGGAGG CCAAGACAGG AGGATCACTT GAGGCCAGGA GTCTGAGACA 1980 AGCCTAGGCA ACAAAACAAG ACTCTGTCTC TACAAAAAGT TTAAGAAATG AGCCAGACAT 2040 GGTGGTGTAT GCCTGTAGTC CCAGCCACTC AGAAGGCTGA GGCAGGAGGA TCGCTTGAGA 2100 CCAAGAGTTT GAGCCTGCGG TGAGCTGTGA ATGCACCACG GCACTCAAGC CTGGGCAATG 2160 TAGCAAGATC CTGTCTCTAC AAGAAATTTT TTAAAAATGA GCCAAGTGTG GTGGTGCATG 2220 CCTGTAGTTC CAGCTACTCA GGACACTGAC GTAGGAGGGT TGCTTGAGAC TGAGAGTTGG 2280 AGGCTGCGAT GAGCCATGAA TGCCCCACTG CACTCCAGCC TGGGCGACAG AACGAGACCC 2340 CATCTCAAAA AAAATAAGTT CTGGTTGTCA TTGAATTGGG ATAAACAGAG AGCTTGATGC 2400 TTTCTGCCTT CTGTCTCAGG TGATGCATTG CACATTTGGG ATATTTGGAA AGGAAATGAG 2460 GAAAGAAATT AGGGCCTCCT CTGATCTCTC GCTATCTGCG GGTCCTGTCC TTTTCTCAAG 2520 ACCTTCACCA TTACTGGCAT TTTCCTGTCT TCTCTTTAGT ATGATCCCTC AAAACCTCAC 2580 TAACTGGAAG GATGATTTTG TCTCAGTTTG TACTCCTAAA TAAAAAGTAA ACATGACACC 2640 TCT 2643 Seq ID NO : 101 DNA Sequence Nucleic Acid Accession # : AF258592 Coding sequence : 93.. 1268 1 11 21 31 41 51 ( GTCGCCCCTC AGTCTCCACT AGAGACAGGA CTGACCAGTT GCTCTTCCTT CCAAGAACCT 60 TCGAGATCTG CGGTCTGGGG TCTGGTTGAA AGATGGCGGC CCTCACTACC CTGTTTAAGT 120 ACATAGATGA AAATCAGGAT CGCTACATTA AGAAACTCGC AAAATGGGTG GCTATCCAGA 180 GTGTGTCTGC GTGGCCGGAG AAGAGAGGCG AAATCAGGAG GATGATGGAA GTTGCTGCTG 240 CAGATGTTAA GCAGTTGGGG GGCTCTGTGG AACTGGTGGA TATCGGAAAA CAAAAGGAGA 300 TTCCTGTCAA CGTCCGATTC TGCCTCGAAG GCATGGAGGA GTCAGGCTCT GAGGGCCTAG 360 ACGAGCTGAT TTTTGCCCGG AAAGACACAT TCTTTAAGGA TGTGGACTAT GTCTGCATTT 420 CTGACAATTA CTGGCTGGGA AAGAAGAAGC CCTGCATCAC CTACGGCCTC AGGGGCATTT 480 GCTACTTTTT CATCGAGGTG GAGTGCAGCA ACAAAGACCT CCATTCTGGG GTGTACGGGG 540 GCTCGGTGCA TGAGGCCATG ACTGATCTCA TTTTGCTGAT GGGCTCTTTG GTGGACAAGA 600 GGGGGAACAT CCTGATCCCC GGCATTAACG AGGCCGTGGC CGCCGTCACG GAAGAGGAGC 660 ACAAGCTGTA CGACGACATC GACTTTGACA TAGAGGAGTT TGCCAAGGAT GTGGGGGCGC 720 AGATCCTCCT GCACAGCCAC AAGAAAGACA TCCTCATGCA CCGATGGCGG TACCCGTCTC 780 TGTCCCTCCA TGGCATCGAA GGCGCCTTCT CTGGGTCTGG GGCCAAGACC GTGATTCCCA 840 GGAAGGTGGT TGGCAAGTTC TCCATCAGGC TCGTGCCGAA CATGACTCCT GAAGTCGTCG 900 GCGAGCAGGT CACAAGCTAC CTAACTAAGA AGTTTGCTGA ACTACGCAGC CCCAATGAGT 960 TCAAGGTGTA CATGGGCCAC GGTGGGAAGC CCTGGGTCTC CGACTTCAGT CACCCTCATT 1020 ACCTGGCTGG GAGAAGAGCC ATGAAGACAG TTTTTGGTGT TGAGCCAGAC TTGACCAGGG 1080 AAGGCGGCAG TATTCCCGTG ACCTTGACCT TTCAGGAGGC CACGGGCAAG AACGTCATGC 1140 TGCTGCCTGT GGGGTCAGCG GATGACGGAG CCCACTCCCA GAATGAAAAG CTCAACAGGT 1200 ATAACTACAT AGAGGGAACC AAGATGCTGG CCGCGTACCT GTATGAGGTC TCCCAGCTGA 1260 AGGACTAGGC CAAGCCCTCT GTGTGCCATC TCCAATGAGA AGGAATCCTG CCCTCACCTC 1320 ACCCTTTTCC AACTTGCCCA GGGAAGTGGA GGTTCCCTCT TTCCTTTCCC TCTTGTCAGG 1380 TCATCCATGA CTTTAGAGAA CAGACACAAG TGTATCCAGC TGTCCACGGG TGGAGCTACC 1440 CGTTGGGCTT ATGAGTGACC TGGAGTGACA GCTGAGTCAC CCTGGGTAAG TTCTCAGAGT 1500 GGTCAGGATG GCTTGACCTG CAGAAGATAC CCAAGGTCCA AAAGCACAAG GTCTGCGGAA 1560 AGTTCTGGTT GTCGGCTGGG CACCACGGCT CACACCTATA ATCGAGCACT TTGGGAGGCC 1620 AAGACAGGAG GATCACTTGA GGCCAGGAGT CTGAGACAAG CCTAGGCAAC AAAACAAGAC 1680 TCTGTCTCTA CAAAAAGTTT AAGAAATGAG CCAGACATGG TGGTGTATGC CTGTAGTCCC 1740 AGCCACTCAG AAGGCTGAGG CAGGAGGATC GCTTGAGACC AAGAGTTTGA GCCTGCGGTG 1800 AGCTGTGAAT GCACCACGGC ACTCAAGCCT GGGCAATGTA GCAAGATCCT GTCTCTACAA 1860 GAAATTTTTT AAAAATGAGC CAAGTGTGGT GGTGCATGCC TGTAGTTCCA GCTACTCAGG 1920 ACACTGACGT AGGAGGGTTG CTTGAGACTG AGAGTTGGAG GCTGCGATGA GCCATGAATG 1980 CCCCACTGCA CTCCAGCCTG GGCGACAGAA CGAGACCCCA TCTCAAAAAA AATAAGTTCT 2040 GGTTGTCATT GAATTGGGAT AAACAGAGAG CTTGATGCTT TCTGCCTTCT GTCTCAGGTG 2100 ATGCATTGCA CATTTGGGAT ATTTGGAAAG GAAATGAGGA AAGAAATTAG GGCCTCCTCT 2160 GATCTCTCGC TATCTGCGGG TCCTGTCCTT TTCTCAAGAC CTTCACCATT ACTGGCATTT 2220 TCCTGTCTTC TCTTTAGTAT GATCCCTCAA AACCTCACTA ACTGGAAGGA TGATTTTGTC 2280 TCAGTTTGTA CTCCTAAATA AAAAGTAAAC ATGACACCTC TAAAAAAAAA AAAAAAAAAA 2340 AAAAAAAAA 2349 Seq ID NO : 102 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TTTTTTACAA AGGGACTTAA AATTGTCAGG ATGATGGCAT ATCATCAGTG AGATGCTTCT 60 ACGTTGATGT GCACTTGTGT ATGCATGTAT TATACATACC CTCATGATGG GAACTGGAGT 120 CAATAATTTT CTTTTCTTTC TTTAGGACAC TTTCCTAGAT CTTTCCACTG TTAACCCAAC 180 CATCCAGATC TCCTAAACTC TCCTGAGAAC TTAGAAATTA ACTCCTTTCC TCTTCCCTAT 240 TTGGCTGCGC TAATAGAGCA GGCATGCAAT ACTAAGCTTC ACAGCTAGGT GTCCTCATAA 300 TGCAATGACT TCCTTTGGCA GCCTAGTCAT TGACAGCTGA CTTTGAGTCA AGAAAGTAAG 360 TTTTCTCTCT CCTTTATGTT TAATTTCTAT TTAGGGAGAT TCCTTATGAG GGATACTTAT 420 GAAGGCCACT TTCCTCCTGC TATGTGCTCA GAGCTAACTC CATATTTTCC TGTAAGTTTA 480

TAAGTAGCTT GCAATTCAGT TAGGTGTCCA CCAATG 516 Seq ID NO : 103 DNA Sequence Nucleic Acid Accession # : UM_018401. 1 Coding sequence : 65.. 1309 1 11 21 31 41 51 GTCCCACATC CCGCATCCGG CATCCCAGCG GCCGGGCATG TAGCAGCGGC AGCAACGGCG 60 GAATATGGGC GGGAACCACT CCCACAAGCC CCCCGTGTTT GACGAGAATG AGGAAGTCAA 120 CTTTGACCAT TTTCAGATTC TGCGGGCCAT TGGTAAAGGG AGTTTTGGAA AGGTATGCAT 180 CGTGCAGAAG CGAGACACTA AGAAAATGTA TGCAATGAAG TACATGAACA AGCAGAAGTG 240 CATCGAGAGG GATGAGGTTC GGAATGTTTT CCGGGAGCTG CAGATCATGC AAGGGCTGGA 300 GCACCCCTTC CTGGTCAATC TGTGGTACTC CTTCCAGGAT GAGGAGGACA TGTTCATGGT 360 GGTGGACCTG CTCCTGGGAG GCGACCTGCG CTACCATCTG CAGCAGAATG TGCATTTCAC 420 AGAGGGGACT GTGAAACTCT ACATCTGTGA GCTGGCACTG GCCCTGGAGT ATCTTCAGAG 480 GTACCACATC ATCCACAGAG ACATCAAGCC AGACAATATC CTGCTGGATG AACACGGACA 540 TGTTCACATT ACAGACTTCA ACATAGCGAC GGTAGTGAAA GGAGCAGAAA GGGCTTCCTC 600 CATGGCTGGC ACCAAGCCCT ACATGGCTCC AGAAGTATTC CAGGTGTACA TGGACAGAGG 660 CCCCGGATAC TCGTACCCTG TCGACTGGTG GTCCCTGGGC ATCACAGCCT ATGAGCTGCT 720 GCGGGGCTGG AGGCCGTACG AAATCCACTC GGTCACGCCC ATCGATGAAA TCCTCAACAT 780 GTTCAAGGTG GAGCGTGTCC ACTACTCCTC CACGTGGTGC AAGGGGATGG TGGCCCTGCT 840 GAGGAAGCTC CTGACCAAGG ATCCTGAGAG CCGCGTGTCC AGCCTTCATG ACATACAGAG 900 CGTGCCCTAC TTGGCCGACA TGAACTGGGA CGCGGTGTTC AAGAAGGCAC TGATGCCCGG 960 CTTTGTGCCC AATAAAGGGA GGTTGAACTG CGATCCCACA TTTGAGCTTG AAGAGATGAT 1020 TCTAGAATCC AAGCCACTTC ACAAAAAGAA GAAGCGATTG GCAAAGAACA GATCCAGGGA 1080 TGGCACAAAG GACAGCTGCC CGCTGAATGG ACACCTGCAG CACTGTTTGG AGACTGTCCG 1140 GGAGGAATTC ATCATATTCA ACAGAGAGAA GCTCAGGAGG CAGCAGGGAC AGGGCAGCCA 1200 GCTCTTGGAC ACCGACAGCC GAGGGGGAGG CCAGGCCCAA AGCAAGCTCC AGGACGGGTG 1260 CAACAACAAC CTCCTCACCC ACACCTGCAC CCGTGGCTGC AGCAGCTGAG CCCACACTTG 1320 TTGCTGCTCA ACAGGACTGC ACTCGTCTCT GCCCTGCCCA CCCAGAGCCC CTCTTTGTGC 1380 CCTGATGGTC CCTGTCTCAC CCCTGAAAAC ATCAGATGCA GAAAAAGCCC TGGACTTGGA 1440 GCTGGGAAGC CTGGGTTCTG GTCCCATCTC CATGACTGAT TCACGTGTGA CCTCAGACAA 1500 GTCACGCCCT CTCTGTGCCT CCGTTTTCTG CATCTGCCAA AGGGGTTAAA CACTTCTGCC 1560 CCACTTCAAA TTACAAGATT ATGGGGAGAA CCCAATTAGG TAGGAAACAT GAAAAACCTT 1620 TGATATTTAT AAAATCATTT TTACGTGCAA AATATAACCT TAATATTTGA AGTGACCCCC 1680 ATTCCCCAAA GCAATCAAAC CGTCATGACT TTGCAATTTG GCACATCCTA GCTTGTTAGA 1740 GGGCACTTCC GAAAAACACA GCCCTGACAG CAAAATAAAG GTCTGATATG TTGGCCCCTT 1800 CTATGGAAAC AACGCTGCCA AATCCTGGAG CAAAACCTGA AGTGTCTTCA TGTGCATTCT 1860 CTGGCAGGCC ACAGTCCTGA GCTTGTAAGA TGGTGCAGCA TGCAGACCAG ACTTGTCCCC 1920 AAGGTCTCAG CGCTGCGGTC TCACTCCTCC CCTCATTTAA GAAGACTATC CTTACCTTTT 1980 AGTTTCAGCA GTCCTCACCA CCACCATATC CCCAGTGCTG GGATGGCACA CAGGTGTCCA 2040 TTCAGATGAG AGTTGGGTCG CTGAGCATTG GTTACTCCTG CAGAGTGTAA TCAGCACCCC 2100 ATCCAACTGG CCCGAAAGCC CAGACCTGCA GCAGAACTCT CCAACTCTCT ATCAGCTTTC 2160 AGGGTTTTCT CTCCTGGGAA GGGTGTAAAA TCAGCTTGTC AGATTCTTCT TACAGAGAGT 2220 ATCCAATCGG TATTGGTGGA GCGGCTCCCT ATTTATACAA TAGGAAGCAT GGGTGCTTAG 2280 AAAGTTTATT TCAGGAGGAA AATGGGTTCA CACAAAAAGC AAACTACATT CTGATCTGCT 2340 CAGGGAGAAG CTTGCCTTTG AACTGGAAGA TGTTGGGATG AGCAGGGAAA GCTTAGACTT 2400 TGGAGTCAGG TTTGTGTTCA GAATCCAGCC CTGCTGGCTA CTAACTAACT GGGAGACCTT 2460 AGGCAAAGCA TGCAATCGCT CTGAATGGCA GTTTCCTCAT TTTTAAACAG GGATAATAAA 2520 ACTAATATTG CAGGGGAGTT ACAGGGTTAA ATAAGATCCT GTGTGTAACC CCAAGCATTG 2580 GATGACTCAT AGAATGGCCT TTTTTGTCAG CATAATCGTC ATCATTATTT AGATACTTTC 2640 TTCCTTCACT CACCCAGCAG GTCAGTTTTC TGTGCAAACA AACCTGTTTA GGATTCTTCC 2700 AAATGTTCTT CCTGGGGTCT TTGATATTTG TTTGTTACAT CCTGCTGAAG TTCGACTGTG 2760 TTTTTATTTT TTCATCCAAC TTCCATTTTT CACTTTTTAC ATGATTACTC AATCCTTGGG 2820 GCTGTCCATG TCATCTCTTA GATTTCTTAA AAGACATTTT AATGTATGGT TAGGTTTTAT 2880 ATTTTTATTT TTTAAAAAAG AAATAGTCAG TGTTTTCCTC CTTTCAACCG AGACTATTTC 2940 TGGATTGTGT GCTCCTCGTC AGTTGACTTG TTTTGCACAC TTTTCTTTAC TTCATGTCCC 3000 CATCAACAAC CGTCCTGCTC CCCACCTCCC CCAGGAAATA AGGGGCCTGC TCCTCTCCCT 3060 ACTGTGACCC TGGAGGCTCT TAAGATGATG ATGGTTTTTT TTATTGGGCT GAGTTCACGA 3120 ATTAGGGGCA GGAGCTGGAA GTCGCCCTAG GAACACCAGA TTTCCTGGTT CTGTTCAAGT 3180 TGGCATTTCT TGTTTGGAAT AAACTATTTC TTGGACATTC CTTC 3224 Seq ID NO : 104 DNA Sequence Nucleic Acid Accession # : Nom 004207. 1 Coding sequence : 63.. 1460 1 11 21 31 41 51 I I I I I I GGCGAGAGGC GGGCTGAGGC GGCCCAGCGG CGGCAGGTGA GGCGGAACCA ACCCTCCTGG 60 CCATGGGAGG GGCCGTGGTG GACGAGGGCC CCACAGGCGT CAAGGCCCCT GACGGCGGCT 120 GGGGCTGGGC CGTGCTCTTC GGCTGTTTCG TCATCACTGG CTTCTCCTAC GCCTTCCCCA 180 AGGCCGTCAG TGTCTTCTTC AAGGAGCTCA TACAGGAGTT TGGGATCGGC TACAGCGACA 240 CAGCCTGGAT CTCCTCCATC CTGCTGGCCA TGCTCTACGG GACAGGTCCG CTCTGCAGTG 300 TGTGCGTGAA CCGCTTTGGC TGCCGGCCCG TCATGCTTGT GGGGGGTCTC TTTGCGTCGC 360 TGGGCATGGT GGCTGCGTCC TTTTGCCGGA GCATCATCCA GGTCTACCTC ACCACTGGGG 420 TCATCACGGG GTTGGGTTTG GCACTCAACT TCCAGCCCTC GCTCATCATG CTGAACCGCT 480 ACTTCAGCAA GCGGCGCCCC ATGGCCAACG GGCTGGCGGC AGCAGGTAGC CCTGTCTTCC 540 TGTGTGCCCT GAGCCCGCTG GGGCAGCTGC TGCAGGACCG CTACGGCTGG CGGGGCGGCT 600 TCCTCATCCT GGGCGGCCTG CTGCTCAACT GCTGCGTGTG TGCCGCACTC ATGAGGCCCC 660 TGGTGGTCAC GGCCCAGCCG GGCTCGGGGC CGCCGCGACC CTCCCGGCGC CTGCTAGACC 720 TGAGCGTCTT CCGGGACCGC GGCTTTGTGC TTTACGCCGT GGCCGCCTCG GTCATGGTGC 780 TGGGGCTCTT CGTCCCGCCC GTGTTCGTGG TGAGCTACGC CAAGGACCTG GGCGTGCCCG 840 ACACCAAGGC CGCCTTCCTG CTCACCATCC TGGGCTTCAT TGACATCTTC GCGCGGCCGG 900 CCGCGGGCTT CGTGGCGGGG CTTGGGAAGG TGCGGCCCTA CTCCGTCTAC CTCTTCAGCT 960 TCTCCATGTT CTTCAACGGC CTCGCGGACC TGGCGGGCTC TACGGCGGGC GACTACGGCG 1020

GCCTCGTGGT CTTCTGCATC TTCTTTGGCA TCTCCTACGG CATGGTGGGG GCCCTGCAGT 1080 TCGAGGTGCT CATGGCCATC GTGGGCACCC ACAAGTTCTC CAGTGCCATT GGCCTGGTGC 1140 TGCTGATGGA GGCGGTGGCC GTGCTCGTCG GGCCCCCTTC GGGAGGCAAA CTCCTGGATG 1200 CGACCCACGT CTACATGTAC GTGTTCATCC TGGCGGGGGC CGAGGTGCTC ACCTCCTCCC 1260 TGATTTTGCT GCTGGGCAAC TTCTTCTGCA TTAGGAAGAA GCCCAAAGAG CCACAGCCTG 1320 AGGTGGCGGC CGCGGAGGAG GAGAAGCTCC ACAAGCCTCC TGCAGACTCG GGGGTGGACT 1380 TGCGGGAGGT GGAGCATTTC CTGAAGGCTG AGCCTGAGAA AAACGGGGAG GTGGTTCACA 1440 CCCCGGAAAC AAGTGTCTGA GTGGCTGGGC GGGGCCGGCA GGCACAGGGA GGAGGTACAG 1500 AAGCCGGCAA CGCTTGCTAT TTATTTTACA AACTGGACTG GCTCAGGCAG GGCCACGGCT 1560 GGGCTCCAGC TGCCGGCCCA GCGGATCGTC GCCCGATCAG TGTTTTGAGG GGGAAGGTGG 1620 CGGGGTGGGA ACCGTGTCAT TCCAGAGTGG ATCTGCGGTG AAGCCAAGCC GCAAGGTTAC 1680 AAGGCATCCT CACCAGGGGC CCCGCCTGCT GCTCCCAGGT GGCCTGCGGC CACTGCTATG 1740 CTCAAGGACC TGGAAACCCA TGCTTCGAGA CAACGTGACT TTAATGGGAG GGTGGGTGGG 1800 CCGCAGACAG GCTGGCAGGG CAGGTGCTGC GTGGGGCCCT CTCCAGCCCG TCCTACCCTG 1860 GGCTCACATG GGGCCTGTGC CCACCCCTCT TGAGTGTCTT GGGGACAGCT CTTTCCACCC 1920 CTGGAAGATG GAAATAAACC TGCGTGTGGG TGGAGTGTTC TCGTGCCGAA TTCAAAAAGC 1980 TT 1982 Seq ID NO : 105 DNA Sequence Nucleic Acid Accession # : NM 006598. 1 Coding sequence : 5.. 3256 1 11 21 31 41 51 AGCCATGCCC ACGAACTTTA CGGTGGTGCC CGTGGAGGCT CACGCCGACG GCGGCGGGGA 60 CGAGACTGCC GAGCGGACGG AGGCTCCGGG CACCCCCGAG GGCCCCGAGC CCGAGCGCCC 120 CAGCCCGGGA GATGGAAATC CAAGAGAAAA CAGCCCATTC CTCAACAATG TCGAGGTGGA 180 ACAAGAGAGC TTCTTTGAAG GGAAGAACAT GGCACTTTTC GAGGAGGAGA TGGACAGTAA 240 CCCCATGGTG TCCTCGCTGC TCAACAAGCT GGCCAACTAC ACCAACCTGA GCCAGGGCGT 300 GGTGGAGCAC GAGGAGGACG AGGAGAGCCG GCGGCGGGAG GCCAAGGCTC CGCGCATGGG 360 CACCTTCATC GGCGTCTACC TGCCGTGCCT GCAGAACATC CTGGGCGTCA TCCTCTTCCT 420 GCGCCTGACG TGGATCGTGG GGGTGGCTGG TGTCCTGGAG TCCTTCCTCA TCGTGGCCAT 480 GTGCTGCACA TGTACAATGC TGACCGCCAT TTCCATGAGT GCGATCGCTA CCAACGGTGT 540 GGTCCCAGCT GGCGGGTCCT ACTACATGAT ATCGCGCTCG CTGGGACCCG AGTTTGGAGG 600 CGCTGTCGGC CTCTGCTTCT ACCTGGGCAC GACGTTTGCA GGGGCCATGT ATATTTTGGG 660 GACCATCGAG ATTTTTCTGA CGTACATCTC CCCGGGTGCG GCCATCTTCC AGGCGGAGGC 720 TGCAGGTGGC GAGGCGGCCG CCATGCTGCA CAACATGCGT GTGTACGGCA CGTGCACGCT 780 CGTGCTCATG GCCCTGGTGG TCTTCGTGGG CGTCAAGTAT GTCAACAAGC TGGCGCTGGT 840 CTTCCTGGCC TGCGTCGTGC TGTCCATCCT GGCCATCTAT GCCGGCGTCA TCAAGTCTGC 900 CTTCGACCCC CCGGACATCC CGGTCTGCCT CCTGGGGAAC CGCACGCTGT CACGGCGCAG 960 CTTCGATGCC TGCGTCAAGG CCTACGGCAT CCACAACAAC TCAGCCACCT CCGCGCTCTG 1020 GGGCCTCTTC TGCAACGGCT CCCAGCCCAG CGCCGCCTGT GACGAGTACT TCATCCAGAA 1080 CAACGTCACC GAAATCCAGG GCATCCCGGG CGCGGCCAGT GGTGTCTTCC TGGAGAACCT 1140 GTGGAGTACG TACGCGCACG CGGGGGCGTT TGTGGAGAAG AAAGGTGTGC CCTCGGTGCC 1200 CGTGGCAGAG GAGAGCCGTG CCAGCACACT GCCCTACGTG CTCACCGACA TCGCGGCCTC 1260 CTTCACCCTG CTGGTTGGCA TCTACTTCCC TTCCGTGACC GGTATCATGG CGGGTTCAAA 1320 CCGGTCCGGG GACCTCAAGG ATGCACAGAA GTCCATCCCC ACGGGGACCA TCCTGGCCAT 1380 AGTGACGACG TCTTTCATCT ATCTCTCCTG CATTGTGCTG TTTGGGGCCT GCATTGAAGG 1440 CGTGGTCTTA CGAGATAAGT TCGGGGAGGC CCTGCAGGGG AACCTGGTCA TCGGCATGCT 1500 GGCCTGGCCC TCCCCCTGGG TCATCGTCAT CGGCTCCTTC TTCTCCACCT GCGGTGCCGG 1560 CCTGCAGACC CTCACGGGGG CACCGCGCCT ACTGCAGGCC ATTGCCCGTG ACGGCATCGT 1620 CCCCTTCCTG CAGGTGTTTG GCCACGGGAA GGCCAACGGG GAGCCCACGT GGGCGCTGCT 1680 GCTGACAGTC CTCATCTGCG AGACTGGCAT CCTCATCGCC TCTCTGGACA GCGTGGCCCC 1740 GATCCTCTCC ATGTTCTTCC TCATGTGCTA CCTGTTCGTG AACCTGGCCT GCGCCGTGCA 1800 GACCCTGCTA CGTACCCCCA ACTGGCGTCC ACGCTTCAAG TTCTACCACT GGACCCTGTC 1860 CTTTCTGGGT ATGAGCCTGT GCCTGGCGCT GATGTTCATC TGCTCCTGGT ACTACGCGCT 1920 GTCCGCCATG CTCATCGCTG GCTGCATCTA CAAGTACATC GAGTACCGCG GGGCCGAGAA 1980 GGAGTGGGGC GATGGCATCC GTGGCCTATC CCTGAACGCC GCCCGCTACG CCCTGCTGCG 2040 CGTGGAGCAC GGTCCCCCCC ACACCAAGAA CTGGAGGCCC CAGGTGCTGG TGATGCTGAA 2100 CCTGGACGCG GAGCAGGCCG TGAAGCACCC CCGCCTGCTG TCCTTCACGT CGCAGCTGAA 2160 GGCCGGCAAG GGCCTGACCA TCGTGGGCTC GGTGCTGGAG GGGACGTACC TGGACAAGCA 2220 CATGGAGGCT CAGCGGGCCG AGGAGAACAT ACGGTCCCTA ATGAGCACAG AGAAGACCAA 2280 GGGCTTCTGC CAGCTGGTGG TCTCGTCCAG CCTGCGGGAT GGCATGTCCC ACCTGATCCA 2340 GTCGGCCGGC CTGGGCGGCC TGAAGCACAA CACGGTGCTC ATGGCCTGGC CCGCATCCTG 2400 GAAGCAGGAG GACAACCCCT TCTCCTGGAA GAACTTTGTA GACACCGTCC GCGACACCAC 2460 CGCCGCGCAC CAGGCTCTGC TGGTGGCCAA GAACGTCGAC TCGTTTCCGC AAAACCAGGA 2520 GCGCTTCGGC GGGGGCCACA TCGACGTGTG GTGGATCGTG CACGACGGCG GCATGCTCAT 2580 GCTGCTGCCC TTCCTGCTGC GCCAGCACAA GGTGTGGAGG AAGTGCCGGA TGCGTATCTT 2640 CACCGTGGCC CAGGTGGACG ACAACAGCAT CCAGATGAAG AAGGACCTGC AGATGTTCTT 2700 GTATCACTTG CGCATCAGCG CCGAGGTGGA GGTGGTGGAG ATGGTTGAAA ACGACATATC 2760 TGCTTTCACC TACGAGAGGA CACTAATGAT GGAGCAGAGG TCGCAGATGC TGAAGCAGAT 2820 GCAGCTGTCC AAGAACGAGC AGGAGCGAGA GGCCCAGCTG ATCCACGACA GGAACACCGC 2880 GTCCCACACC GCGGCGGCAG CCAGGACCCA AGCGCCGCCT ACGCCAGACA AGGTGCAGAT 2940 GACCTGGACC AGGGAGAAGC TGATCGCTGA GAAGTACAGG AGCAGAGACA CCAGCCTATC 3000 CGGTTTCAAA GACCTCTTCA GCATGAAGCC GGACCAGTCC AACGTCAGGC GGATGCACAC 3060 GGCTGTGAAG CTCAATGGCG TCGTCCTCAA CAAGTCCCAG GATGCGCAGC TGGTCCTGCT 3120 CAACATGCCA GGTCCTCCCA AAAACCGGCA GGGAGACGAG AACTACATGG AGTTTCTTGA 3180 AGTCCTGACC GAGGGGCTGA ACAGAGTCCT CCTGGTCAGG GGTGGCGGCC GGGAGGTGAT 3240 CACCATCTAC TCCTAATGCC CAACAGCATC ACGGCACTCT GGGACAGGCA CGGAGGACGG 3300 CGTGGGCAGC CTGGGCCTGG GCTTGGCCCA GGGAACCAGA CGGCAGACAC ACCTGTCCCC 3360 CAGTGATGCC ACCCAAGCTG CCCATGGGGC TTCCTACGGA AGTTTCTAGG CCCGTCACCT 3420 AGGGCTCTCC TGTTCAGCCT TAACAGGCTC AGCAAATCAG GGCGTGGCTG GACGATTTCC 3480 TTGCATCTGA GGGCAGACGC TGCTACCGGA GTGACCTGGA CGTGGCCAGA TCTTCTCGCA 3540 GGTCACAAGA AGCCAGTGAG CCCTTGCCTT GGTTTCTGGA AGTTCTTTTC CTTGGCTGGA 3600 TTTACCCAGT GGTTAGGTTG CATTTCTACC CCATCCAGAA CATTCTTGGA AGAGCACCCG 3660

GAGCTGAAGC TGTCCCTGAT GATGAAGGTG AAACGTCAGC CCTGGCCATG GCTCCGCTCA 3720 GGGCCCCGGT CACCTCCGAG TCACTCTGTT CCTTGACTGT CTTTGTGTTT CTGTACCTCA 3780 AGGCACTGAA GCTGGAGGAC TCTGTCCATG CCCGTGTCAC CCTCGTGTGG GAGCCTCTGG 3840 GCTCGGCAGG TCCACATTTC ATGAGCTGAG GCGTGGGCCA GGGCCATCTG GAAAGGGAAC 3900 TCGGCTTTTC CAGAACGTGG TGGATCATCT GTCGGGTGTG TGGTGAACAC GTTCAGTTCA 3960 TCAGGGCCTA CGCTCCGGGA AGGGGCCCCC AGCTGTGGCT CTGCCATGCC GGGCTGTGTT 4020 TGCAGCTGTC CGAGTCTCCA TCCACCTTTA GAAAACCAGT CACTTCTTTT CATAAGCACT 4080 GACAGGGCCC AGCCCACAGC CACAGGTGCG ATCAGTGCCT CACGCAGGCA AATGCACTGA 4140 AACCCAGGGG CACACGCGCG CAGAGTGAAC AGTGAGTTCC CCCGACAGCC CACGACAGCC 4200 AGGACTGCCC TCCCCACCCC ACCCCACCCC AGGAGCACGG CACACAGTTC AGCCTCTGAG 4260 CTGGCTCACA CGTGCCATCC CCACCCCGGT GCTCCAGGGA AGGAGGACAC GGACCCGACG 4320 TGGGAGGTCC TCAGGCAGCA GTGGCGCCTG GTGTCAGGTC TGTCTGGCTG AGTCCCGGGC 4380 GTCCCCTGCC ATGGCCTGTG CCTTGCATGG AGGCGGCGGT GGCACTGAAG AGATAGCTTT 4440 CAAGGGCCCA ACACTTTGCA CTTCGGCTGG CTGTGAGTTT CTGCTTTGTA GGTTGTGGTC 4500 ACATTTGCAG GCTGCGGGCA GTGGCACCGA CTTGGGCCTC CCTTTCTATG TGGCATATTT 4560 ATTTATTTAA ACACCCCAGG GAGTTACGTG GTAACAAGGT TGTCCATAAA GAGGTTGCTT 4620 CTATATACTA GAGGCCCCAG ATGGCAGGCC TTGGGCTACG TCTGGCTTGC ATGGTCTCCC 4680 AAGGGAATCA ACCCCATCAA CAAAGTTCAA ATCGGGGCAG AGGCTGCACT TGTGCCCCCA 4740 GATGTTTCTG AGGAGCCAGA TTAGGGCTGG CATTGCTGTA GAGTGACGGC TGCTGCCCAG 4800 AGCGTGTCCC AGACATCACA GCGGGGCTCA GCAGTTCCCA CAGCCTCTGC CTGCCTTGGC 4860 TAAGCATGAG TTAAGCAGCA AAACGCTCCT CCATGTCTGG ATGGGGCCGG CAGGTCCTGT 4920 GTCCCCTGCA CCTGGAGGAG AGCAGGCTAG AGGCACAGCG GCCACATGGT GCTGGCTCTG 4980 AACGTTGGTT GGTGGCTGGA AAACAGCCCT GCTTCTGAGG GCCGCTCAGT TCTGCACACG 5040 AAACCACCTC CTGAGGGCTC AGCTCTGCCC CCGCCCTGGG CTGCAGCCTC TGCACGCAAG 5100 CACCAGGCAT CCTTTGTGTT GTCAACTCCG TGTAACCAGT AACTACAGCC ATTTACAATT 5160 GACTCCGTTT CCTTTTGTAG GTTTCCCTGT CTGTCTGTGT TAGTAGAAAA ATAAAATCCT 5220 ATGAAATCTG AAAAAAAAA 5239 Seq ID NO : 106 DNA Sequence Nucleic Acid Accession # : NM004585 Coding sequence : 62.. 556 1 11 21 31 41 51 I I I I I-I CCTTCAGCAT AAAAGCTGAT CCACAAACAA GAGGAGCACC AGACCTCCTC TTGGCTTCGA 60 GATGGCTTCG CCACACCAAG AGCCCAAACC TGGAGACCTG ATTGAGATTT TCCGCCTTGG 120 CTATGAGCAC TGGGCCCTGT ATATAGGAGA TGGCTACGTG ATCCATCTGG CTCCTCCAAG 180 TGAGTACCCC GGGGCTGGCT CCTCCAGTGT CTTCTCAGTC CTGAGCAACA GTGCAGAGGT 240 GAAACGGGGG CGCCTGGAAG ATGTGGTGGG AGGCTGTTGC TATCGGGTCA ACAACAGCTT 300 GGACCATGAG TACCAACCAC GGCCCGTGGA GGTGATCATC AGTTCTGCGA AGGAGATGGT 360 TGGTCAGAAG ATGAAGTACA GTATTGTGAG CAGGAACTGT GAGCACTTTG TCGCCCAGCT 420 GAGATATGGC AAGTCCCGCT GTAAACAGGT GGAAAAGGCC AAGGTTGAAG TCGGTGTGGC 480 CACGGCGCTT GGAATCCTGG TTGTTGCTGG ATGCTCTTTT GCGATTAGGA GATACCAAAA 540 AAAAGCAACA GCCTGAAGCA GCCACAAAAT CCTGTGTTAG AAGCAGCTGT GGGGGTCCCA 600 GTGGAGATGA GCCTCCCCCA TGCCTCCAGC AGCCTGACCC TCGTGCCCTG TCTCAGGCGT 660 TCTCTAGATC CTTTCCTCTG TTTCCCTCTC TCGCTGGCAA AAGTATGATC TAATTGAAAC 720 AAGACTGAAG GATCAATAAA CAGCCATCTG CCCCTTCAAA AAAAAAAA 768 Seq ID NO : 107 DNA Sequence Nucleic Acid Accession # : NM 004696. 1 Coding sequence : 183.. 1646 1 11 21 31 41 51 CTTGGCTCTT ACAATGCTCA CTTGTTTTCA CAATGCAGCA AAATGAAATG CCTTAGAAAA 60 AGAGTAACAT TCCAGAAAAC GGTGTAATTT ATTTTTCTTC CTTAATTGCC CCATCTGTGG 120 AGGATTTCTT TGCTGAACAC CACATCAAAG GGATCTTCTG CATTTAAAAT AGAAGAGGCA 180 TCATGCTGAA GAGGGAGGGG AAGGTCCAAC CTTACACTAA AACCCTGGAT GGAGGATGGG 240 GATGGATGAT TGTGATTCAT TTTTTCCTGG TGAATGTGTT TGTGATGGGG ATGACCAAGA 300 CTTTTGCAAT TTTCTTTGTG GTCTTTCAAG AAGAGTTTGA AGGCACCTCA GAGCAAATTG 360 GTTGGATTGG ATCCATCATG TCATCTCTTC GTTTTTGTGC AGGTCCCCTG GTTGCTATTA 420 TTTGTGACAT ACTTGGAGAG AAAACTACCT CCATTCTTGG GGCTTTCGTT GTTACTGGTG 480 GATATCTGAT CAGCAGCTGG GCCACAAGTA TTCCTTTTCT TTGTGTGACT ATGGGACTTC 540 TACCCGGTTT GGGTTCTGCT TTCTTATACC AAGTGGCTGC TGTGGTAACT ACCAAATACT 600 TCAAAAAACG ATTGGCTCTT TCTACAGCTA TTGCCCGTTC TGGGATGGGA CTGACTTTTC 660 TTTTGGCACC CTTTACAAAA TTCCTGATAG ATCTGTATGA CTGGACAGGA GCCCTTATAT 720 TATTTGGAGC TATCGCATTG AATTTGGTGC CTTCTAGTAT GCTCTTAAGA CCCATCCATA 780 TCAAAAGTGA GAACAATTCT GGTATTAAAG ATAAAGGCAG CAGTTTGTCT GCACATGGTC 840 CAGAGGCACA TGCAACAGAA ACACACTGCC ATGAGACAGA AGAGTCTACC ATCAAGGACA 900 GTACTACGCA GAAGGCTGGA CTACCTAGCA AAAATTTAAC AGTCTCACAA AATCAAAGTG 960 AAGAGTTCTA CAATGGGCCT AACAGGAACA GACTGTTATT AAAGAGTGAT GAAGAAAGTG 1020 ATAAGGTTAT TTCGTGGAGC TGCAAACAAC TGTTTGACAT TTCTCTCTTT AGAAATCCTT 1080 TCTTCTACAT ATTTACTTGG TCTTTTCTCC TCAGTCAGTT AGCATACTTC ATCCCTACCT 1140 TTCACCTGGT AGCCAGAGCC AAAACACTGG GGATTGACAT CATGGATGCC TCTTACCTTG 1200 TTTCTGTAGC AGGTATCCTT GAGACGGTCA GTCAGATTAT TTCTGGATGG GTTGCTGATC 1260 AAAACTGGAT TAAGAAGTAT CATTACCACA AGTCTTACCT CATCCTCTGC GGCATCACTA 1320 ACCTGCTTGC TCCTTTAGCC ACCACATTTC CACTACTTAT GACCTACACC ATCTGCTTTG 1380 CCATCTTTGC TGGTGGTTAC CTGGCATTGA TACTGCCTGT ACTGGTTGAT CTGTGTAGGA 1440 ATTCTACAGT AAACAGGTTT TTGGGACTTG CCAGTTTCTT TGCTGGGATG GCTGTCCTTT 1500 CTGGACCACC TATAGCAGGC TGGTTATATG ATTATACCCA GACATACAAT GGCTCTTTCT 1560 ACTTCTCTGG CATATGCTAT CTCCTCTCTT CAGTTTCCTT TTTTTTTGTA CCATTGGCCG 1620 AAAGATGGAA AAACAGTCTG ACCTGAAAGA AAGAAGACTG CAATCAAGTG AGAGCTAAAC 1680 AAAAGAAAAC CTAAACTAAT GTCATTGGAA ACAAAAGCTT GAAAGAAACA CATCGCATCT 1740 ACATTTGTAA CATGAGAAGG AAAACAATTT TTTTTTTTTT TTTTTTGAGA CGGAGTCTCG 1800 CTCTTTCGCC CAGGCTGGAG TGCAGTGGCG CAATCTCGGC TCACTGTAAT CTCCGCCTCC 1860 TGGGTTCAAG GGATTCTCCT GCCTCAGCCT CCCAAGTAGC TGGGACTACA GGCACACGCC 1920

ACCACACCCA GCTAATTTTT TGTATTTTTA GTAGAGGCGG GGTTTCACCA TGTTAGCCAG 1980 GATGGTCTCC ATCTCCTGAC CTCGTGATCC GCCCGCCTTG TCCTCCAAAG TGCTGGGATT 2040 ACAGGCATGA GCCACTGGGC GCGGCCAGAT AAGTTTTTAA GGTTCCTTCT TGCTTTAGCA 2100 TTCTGAGAAA TGTCTAATTG GTAGTAAGAC AAGAGTAATA GCAACCTGTA TTGTTAGTAT 2160 TTAACCAAAT AGGCTAAAAT TTTAATCAGG TACCTTATGT ATTAAATAGA AATCGGAATG 2220 TACCATAATA AATCCAAACT CTCAATTACG CCATGGTAAT TCAGTCACTA AAATATGTAA 2280 AGATAGAAAA TTTTTTAATT TAAAGAAGTG TGAAACATAG CCATTGATTG ATCAGAATTC 2340 TGGAATCTGA ATATTAAAAC CTTACTTAGT GACTGGAATG GTATATGCTC CCTCCAAAAG 2400 TTTATCTTTG TTTATTGATT AAAGGTAATC CTTACTTTCT TTGTATTACT TAGGTTCTCA 2460 ATTAAAGGTA ATCCTTACTT TCTTTGTATT ACTTAGGTTC TTAAATTTCT ATGATAAACA 2520 TGTATTGCT 2529 Seq ID NO : 108 DNA Sequence Nucleic Acid Accession # : NM 000358. 1 Coding sequence : 48.. 2099 1 11 21 31 41 51 i I I I I I GCTTGCCCGT CGGTCGCTAG CTCGCTCGGT GCGCGTCGTC CCGCTCCATG GCGCTCTTCG 60 TGCGGCTGCT GGCTCTCGCC CTGGCTCTGG CCCTGGGCCC CGCCGCGACC CTGGCGGGTC 120 CCGCCAAGTC GCCCTACCAG CTGGTGCTGC AGCACAGCAG GCTCCGGGGC CGCCAGCACG 180 GCCCCAACGT GTGTGCTGTG CAGAAGGTTA TTGGCACTAA TAGGAAGTAC TTCACCAACT 240 GCAAGCAGTG GTACCAAAGG AAAATCTGTG GCAAATCAAC AGTCATCAGC TACGAGTGCT 300 GTCCTGGATA TGAAAAGGTC CCTGGGGAGA AGGGCTGTCC AGCAGCCCTA CCACTCTCAA 360 ACCTTTACGA GACCCTGGGA GTCGTTGGAT CCACCACCAC TCAGCTGTAC ACGGACCGCA 420 CGGAGAAGCT GAGGCCTGAG ATGGAGGGGC CCGGCAGCTT CACCATCTTC GCCCCTAGCA 480 ACGAGGCCTG GGCCTCCTTG CCAGCTGAAG TGCTGGACTC CCTGGTCAGC AATGTCAACA 540 TTGAGCTGCT CAATGCCCTC CGCTACCATA TGGTGGGCAG GCGAGTCCTG ACTGATGAGC 600 TGAAACACGG CATGACCCTC ACCTCTATGT ACCAGAATTC CAACATCCAG ATCCACCACT 660 ATCCTAATGG GATTGTAACT GTGAACTGTG CCCGGCTCCT GAAAGCCGAC CACCATGCAA 720 CCAACGGGGT GGTGCACCTC ATCGATAAGG TCATCTCCAC CATCACCAAC AACATCCAGC 780 AGATCATTGA GATCGAGGAC ACCTTTGAGA CCCTTCGGGC TGCTGTGGCT GCATCAGGGC 840 TCAACACGAT GCTTGAAGGT AACGGCCAGT ACACGCTTTT GGCCCCGACC AATGAGGCCT 900 TCGAGAAGAT CCCTAGTGAG ACTTTGAACC GTATCCTGGG CGACCCAGAA GCCCTGAGAG 960 ACCTGCTGAA CAACCACATC TTGAAGTCAG CTATGTGTGC TGAAGCCATC GTTGCGGGGC 1020 TGTCTGTAGA GACCCTGGAG GGCACGACAC TGGAGGTGGG CTGCAGCGGG GACATGCTCA 1080 CTATCAACGG GAAGGCGATC ATCTCCAATA AAGACATCCT AGCCACCAAC GGGGTGATCC 1140 ACTACATTGA TGAGCTACTC ATCCCAGACT CAGCCAAGAC ACTATTTGAA TTGGCTGCAG 1200 AGTCTGATGT GTCCACAGCC ATTGACCTTT TCAGACAAGC CGGCCTCGGC AATCATCTCT 1260 CTGGAAGTGA GCGGTTGACC CTCCTGGCTC CCCTGAATTC TGTATTCAAA GATGGAACCC 1320 CTCCAATTGA TGCCCATACA AGGAATTTGC TTCGGAACCA CATAATTAAA GACCAGCTGG 1380 CCTCTAAGTA TCTGTACCAT GGACAGACCC TGGAAACTCT GGGCGGCAAA AAACTGAGAG 1440 TTTTTGTTTA TCGTAATAGC CTCTGCATTG AGAACAGCTG CATCGCGGCC CACGACAAGA 1500 GGGGGAGGTA CGGGACCCTG TTCACGATGG ACCGGGTGCT GACCCCCCCA ATGGGGACTG 1560 TCATGGATGT CCTGAAGGGA GACAATCGCT TTAGCATGCT GGTAGCTGCC ATCCAGTCTG 1620 CAGGACTGAC GGAGACCCTC AACCGGGAAG GAGTCTACAC AGTCTTTGCT CCCACAAATG 1680 AAGCCTTCCG AGCCCTGCCA CCAAGAGAAC GGAGCAGACT CTTGGGAGAT GCCAAGGAAC 1740 TTGCCAACAT CCTGAAATAC CACATTGGTG ATGAAATCCT GGTTAGCGGA GGCATCGGGG 1800 CCCTGGTGCG GCTAAAGTCT CTCCAAGGTG ACAAGCTGGA AGTCAGCTTG AAAAACAATG 1860 TGGTGAGTGT CAACAAGGAG CCTGTTGCCG AGCCTGACAT CATGGCCACA AATGGCGTGG 1920 TCCATGTCAT CACCAATGTT CTGCAGCCTC CAGCCAACAG ACCTCAGGAA AGAGGGGATG 1980 AACTTGCAGA CTCTGCGCTT GAGATCTTCA AACAAGCATC AGCGTTTTCC AGGGCTTCCC 2040 AGAGGTCTGT GCGACTAGCC CCTGTCTATC AAAAGTTATT AGAGAGGATG AAGCATTAGC 2100 TTGAAGCACT ACAGGAGGAA TGCACCACGG CAGCTCTCCG CCAATTTCTC TCAGATTTCC 2160 ACAGAGACTG TTTGAATGTT TTCAAAACCA AGTATCACAC TTTAATGTAC ATGGGCCGCA 2220 CCATAATGAG ATGTGAGCCT TGTGCATGTG GGGGAGGAGG GAGAGAGATG TACTTTTTAA 2280 ATCATGTTCC CCCTAAACAT GGCTGTTAAC CCACTGCATG CAGAAACTTG GATGTCACTG 2340 CCTGACATTC ACTTCCAGAG AGGACCTATC CCAAATGTGG AATTGACTGC CTATGCCAAG 2400 TCCCTGGAAA AGGAGCTTCA GTATTGTGGG GCTCATAAAA CATGAATCAA GCAATCCAGC 2460 CTCATGGGAA GTCCTGGCAC AGTTTTTGTA AAGCCCTTGC ACAGCTGGAG AAATGGCATC 2520 ATTATAAGCT ATGAGTTGAA ATGTTCTGTC AAATGTGTCT CACATCTACA CGTGGCTTGG 2580 AGGCTTTTAT GGGGCCCTGT CCAGGTAGAA AAGAAATGGT ATGTAGAGCT TAGATTTCCC 2640 TATTGTGACA GAGCCATGGT GTGTTTGTAA TAATAAAACC AAAGAAACAT A 2691 Seq ID NO : 109 DNA Sequence Nucleic Acid Accession # : NM 145648 Coding sequence : 59.. 1792 1 11 21 31 41 51 CAGGTTGGGT TCTGGGACAG GTGACCCGGC GGCGGGGCGA GGCAGCTGGC GGCGTCGCAT 60 GGAGGGCTCT GGGGGCGGTG CGGGCGAGCG GGCGCCGCTG CTGGGCGCGC GGCGGGCGGC 120 GGCGGCCGCG GCGGCGGCTG GGGCGTTCGC GGGCCGGCGC GCGGCGTGCG GGGCCGTGCT 180 GCTGACGGAG CTGCTGGAGC GCGCCGCTTT CTACGGCATC ACGTCCAACC TGGTGCTATT 240 CCTGAACGGG GCGCCGTTCT GCTGGGAGGG CGCGCAGGCC AGCGAGGCGC TGCTGCTCTT 300 CATGGGCCTC ACCTACCTGG GCTCGCCGTT CGGAGGCTGG CTGGCCGACG CGCGGCTGGG 360 CCGGGCGCGC GCCATCCTGC TGAGCCTGGC GCTCTACCTG CTGGGCATGC TGGCCTTCCC 420 GCTGCTGGCC GCGCCCGCCA CGCGAGCCGC GCTCTGCGGT TCCGCGCGCC TGCTCAACTG 480 CACGGCGCCT GGTCCCGACG CCGCCGCCCG CTGCTGCTCA CCGGCCACCT TCGCGGGGCT 540 GGTGCTGGTG GGCCTGGGCG TGGCCACCGT CAAGGCCAAC ATCACGCCCT TCGGCGCCGA 600 CCAGGTTAAA GATCGAGGTC CGGAAGCCAC TAGGAGATTT TTTAATTGGT TTTATTGGAG 660 CATTAACCTG GGAGCGATCC TGTCGTTAGG TGGCATTGCC TATATTCAGC AGAACGTCAG 720 CTTTGTCACT GGTTATGCGA TCCCCACTGT CTGCGTCGGC CTTGCTTTTG TGGTCTTCCT 780 CTGTGGCCAG AGCGTTTTCA TCACCAAGCC TCCTGATGGC AGTGCCTTCA CCGACATGTT 840 CAAGATACTG ACGTATTCCT GCTGTTCCCA GAAGCGAAGT GGAGAGCGCC AGAGTAATGG 900 TGAAGGCATT GGAGTCTTTC AGCAATCTTC TAAACAAAGT CTGTTTGATT CATGTAAGAT 960

GTCTCATGGT GGGCCATTTA CAGAAGAGAA AGTGGAAGAT GTGAAAGCTC TGGTCAAGAT 1020 TGTCCCTGTT TTCTTGGCTT TGATACCTTA CTGGACAGTG TATTTCCAAA TGCAGACAAC 1080 ATATGTTTTA CAGAGTCTTC ATTTGAGGAT TCCAGAAATT TCAAATATTA CAACCACTCC 1140 TCACACGCTC CCTGCAGCCT GGCTGACCAT GTTTGATGCT GTGCTCATCC TCCTGCTCAT 1200 CCCTCTGAAG GACAAACTGG TCGATCCCAT TTTGAGAAGA CATGGCCTGC TCCCATCCTC 1260 CCTGAAGAGG ATCGCCGTGG GCATGTTCTT TGTCATGTGC TCGGCCTTTG CTGCAGGAAT 1320 TTTGGAGAGT AAAAGGCTGA ACCTTGTTAA AGAGAAAACC ATTAATCAGA CCATCGGCAA 1380 CGTCGTCTAC CATGCTGCCG ATCTGTCGCT GTGGTGGCAG GTGCCGCAGT ACTTGCTGAT 1440 TGGGATCAGC GAGATCTTTG CAAGTATCGC AGGCCTGGAA TTTGCATACT CAGCTGCCCC 1500 CAAGTCCATG CAGAGTGCCA TAATGGGCTT GTTCTTTTTC TTCTCTGGCG TCGGGTCGTT 1560 CGTGGGTTCT GGACTGCTGG CACTGGTGTC TATCAAAGCC ATCGGATGGA TGAGCAGTCA 1620 CACAGACTTT GGTAATATTA ACGGCTGCTA TTTGAACTAT TACTTTTTTC TTCTGGCTGC 1680 TATTCAAGGA GCTACCCTCC TGCTTTTCCT CATTATTTCT GTGAAATATG ACCATCATCG 1740 AGACCATCAG CGATCAAGAG CCAATGGCGT GCCCACCAGC AGGAGGGCCT GACCTTCCTG 1800 AGGCCATGTG CGGTTTCTGA GGCTGACATG TCAGTAACTG ACTGGGGTGC ACTGAGAACA 1860 GGCAAGACTT TAAATTCCCA TAAAATGTCT GACTTCACTG AAACTTGCAT GTTGCCTGGA 1920 TTGATTTCTT CTTTCCCTCT ATCCAAAGGA GCTTGGTAAG TGCCTTACTG CAGCGTGTCT 1980 CCTGGCACGC TGGGCCCTCC GGGAGGAGAG CTGCAGATTT CGAGTATGTC GCTTGTCATT 2040 CAAGGTCTCT GTGAATCCTC TAGCTGGGTT CCCTTTTTTA CAGAAACTCA CAAATGGAGA 2100 TTGCAAAGTC TTGGGGAACT CCACGTGTTA GTTGGCATCC CAGTTTCTTA AACAAATAGT 2160 ATCACCTGCT TCCCATAGCC ATATCTCACT GTAAAAAAAA AAAATTAATA AACTGTTACT 2220 TATATTTAAG AAAGTGAGGA TTTTTTTTTT TTAAAGATAA AAGCATGGTC AGATGCTGCA 2280 AGGATTTTAC ATAAATGCCA TATTTATGGT TTCCTTCCTG AGAACAGTCT TGCTCTTGCC 2340 ATGTTCTTTG ATTTAGGCTG GTAGTAAACA CATTTCATCT GCTGCTTCAA AAAGTACTTA 2400 CTTTTTAAAC CATCAACATT ACTTTTCTTT CTTAAGGCAA GGCATGCATA AGAGTCATTT 2460 GAGACCATGT GTCCCATCTC AAGCCACAGA GCAACTCACA GGGTACTTCA CACCTTACCT 2520 AGTCAGAGTG CTTATATATA GCTTTATTTT GGTACGATTG AGACTAAAGA CTGATCATGG 2580 TTGTATGTAA GGAAAACATT CTTTTGAACA GAAATAGTGT AATTAAAAAT AATTGAAAGT 2640 GTTAAATGTG AACTTGAGCT GTTTGACCAG CCACATTTTT GTATTGTTAC TGTACGTGTA 2700 TCTGGGGCTT CTCCGTTTGT TAATACTTTT TCTGTATTTG TTGCTGTATT TTTGGCATAA 2760 CTTTATTATA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA 2807 Seq ID NO : 110 DNA Sequence Nucleic Acid Accession # : NM001250 Coding sequence : 48.. 881 1 11 21 31 41 51 GCCTCGCTCG GGCGCCCAGT GGTCCTGCCG CCTGGTCTCA CCTCGCCATG GTTCGTCTGC 60 CTCTGCAGTG CGTCCTCTGG GGCTGCTTGC TGACCGCTGT CCATCCAGAA CCACCCACTG 120 CATGCAGAGA AAAACAGTAC CTAATAAACA GTCAGTGCTG TTCTTTGTGC CAGCCAGGAC 180 AGAAACTGGT GAGTGACTGC ACAGAGTTCA CTGAAACGGA ATGCCTTCCT TGCGGTGAAA 240 GCGAATTCCT AGACACCTGG AACAGAGAGA CACACTGCCA CCAGCACAAA TACTGCGACC 300 CCAACCTAGG GCTTCGGGTC CAGCAGAAGG GCACCTCAGA AACAGACACC ATCTGCACCT 360 GTGAAGAAGG CTGGCACTGT ACGAGTGAGG CCTGTGAGAG CTGTGTCCTG CACCGCTCAT 420 GCTCGCCCGG CTTTGGGGTC AAGCAGATTG CTACAGGGGT TTCTGATACC ATCTGCGAGC 480 CCTGCCCAGT CGGCTTCTTC TCCAATGTGT CATCTGCTTT CGAAAAATGT CACCCTTGGA 540 CAAGCTGTGA GACCAAAGAC CTGGTTGTGC AACAGGCAGG CACAAACAAG ACTGATGTTG 600 TCTGTGGTCC CCAGGATCGG CTGAGAGCCC TGGTGGTGAT CCCCATCATC TTCGGGATCC 660 TGTTTGCCAT CCTCTTGGTG CTGGTCTTTA TCAAAAAGGT GGCCAAGAAG CCAACCAATA 720 AGGCCCCCCA CCCCAAGCAG GAACCCCAGG AGATCAATTT TCCCGACGAT CTTCCTGGCT 780 CCAACACTGC TGCTCCAGTG CAGGAGACTT TACATGGATG CCAACCGGTC ACCCAGGAGG 840 ATGGCAAAGA GAGTCGCATC TCAGTGCAGG AGAGACAGTG AGGCTGCACC CACCCAGGAG 900 TGTGGCCACG TGGGCAAACA GGCAGTTGGC CAGAGAGCCT GGTGCTGCTG CTGCAGGGGT 960 GCAGGCAGAA GCGGGGAGCT ATGCCCAGTC AGTGCCAGCC CCTC 1004 Seq ID NO : 111 DNA Sequence Nucleic Acid Accession # : NM 00384. 3 Coding sequence : 286.. 1608 1 11 21 31 41 51 ( GCGCTTGCGG AGGATTGCGT TGACGAGACT CTTATTTATT GTCACCAACC TGTGGTGGAA 60 TTTGCAGTTG CACATTGGAT CTGATTCGCC CCGCCCCGAA TGACGCCTGC CCGGAGGCAG 120 TGAAAGTACA GCCGCGCCGC CCCAAGTCAG CCTGGACACA TAAATCAGCA CGCGGCCGGA 180 GAACCCCGCA ATCTCTGCGC CCACAAAATA CACCGACGAT GCCCGATCTA CTTTAAGGGC 240 TGAAACCCAC GGGCCTGAGA GACTATAAGA GCGTTCCCTA CCGCCATGGA ACAACGGGGA 300 CAGAACGCCC CGGCCGCTTC GGGGGCCCGG AAAAGGCACG GCCCAGGACC CAGGGAGGCG 360 CGGGGAGCCA GGCCTGGGCT CCGGGTCCCC AAGACCCTTG TGCTCGTTGT CGCCGCGGTC 420 CTGCTGTTGG TCTCAGCTGA GTCTGCTCTG ATCACCCAAC AAGACCTAGC TCCCCAGCAG 480 AGAGCGGCCC CACAACAAAA GAGGTCCAGC CCCTCAGAGG GATTGTGTCC ACCTGGACAC 540 CATATCTCAG AAGACGGTAG AGATTGCATC TCCTGCAAAT ATGGACAGGA CTATAGCACT 600 CACTGGAATG ACCTCCTTTT CTGCTTGCGC TGCACCAGGT GTGATTCAGG TGAAGTGGAG 660 CTAAGTCCCT GCACCACGAC CAGAAACACA GTGTGTCAGT GCGAAGAAGG CACCTTCCGG 720 GAAGAAGATT CTCCTGAGAT GTGCCGGAAG TGCCGCACAG GGTGTCCCAG AGGGATGGTC 780 AAGGTCGGTG ATTGTACACC CTGGAGTGAC ATCGAATGTG TCCACAAAGA ATCAGGTACA 840 AAGCACAGTG GGGAAGCCCC AGCTGTGGAG GAGACGGTGA CCTCCAGCCC AGGGACTCCT 900 GCCTCTCCCT GTTCTCTCTC AGGCATCATC ATAGGAGTCA CAGTTGCAGC CGTAGTCTTG 960 ATTGTGGCTG TGTTTGTTTG CAAGTCTTTA CTGTGGAAGA AAGTCCTTCC TTACCTGAAA 1020 GGCATCTGCT CAGGTGGTGG TGGGGACCCT GAGCGTGTGG ACAGAAGCTC ACAACGACCT 1080 GGGGCTGAGG ACAATGTCCT CAATGAGATC GTGAGTATCT TGCAGCCCAC CCAGGTCCCT 1140 GAGCAGGAAA TGGAAGTCCA GGAGCCAGCA GAGCCAACAG GTGTCAACAT GTTGTCCCCC 1200 GGGGAGTCAG AGCATCTGCT GGAACCGGCA GAAGCTGAAA GGTCTCAGAG GAGGAGGCTG 1260 CTGGTTCCAG CAAATGAAGG TGATCCCACT GAGACTCTGA GACAGTGCTT CGATGACTTT 1320 GCAGACTTGG TGCCCTTTGA CTCCTGGGAG CCGCTCATGA GGAAGTTGGG CCTCATGGAC 1380 AATGAGATAA AGGTGGCTAA AGCTGAGGCA GCGGGCCACA GGGACACCTT GTACACGATG 1440

CTGATAAAGT GGGTCAACAA AACCGGGCGA GATGCCTCTG TCCACACCCT GCTGGATGCC 1500 TTGGAGACGC TGGGAGAGAG ACTTGCCAAG CAGAAGATTG AGGACCACTT GTTGAGCTCT 1560 GGAAAGTTCA TGTATCTAGA AGGTAATGCA GACTCTGCCA TGTCCTAAGT GTGATTCTCT 1620 TCAGGAAGTC AGACCTTCCC TGGTTTACCT TTTTTCTGGA AAAAGCCCAA CTGGACTCCA 1680 GTCAGTAGGA AAGTGCCACA ATTGTCACAT GACCGGTACT GGAAGAAACT CTCCCATCCA 1740 ACATCACCCA GTGGATGGAA CATCCTGTAA CTTTTCACTG CACTTGGCAT TATTTTTATA 1800 AGCTGAATGT GATAATAAGG ACACTATGGA AATGTCTGGA TCATTCCGTT TGTGCGTACT 1860 TTGAGATTTG GTTTGGGATG TCATTGTTTT CACAGCACTT TTTTATCCTA ATGTAAATGC 1920 TTTATTTATT TATTTGGGCT ACATTGTAAG ATCCATCTAC ACAGTCGTTG TCCGACTTCA 1980 CTTGATACTA TATGATATGA ACCTTTTTTG GGTGGGGGGT GCGGGGCAGT TCACTCTGTC 2040 TCCCAGGCTG GAGTGCAATG GTGCAATCTT GGCTCACTAT AGCCTTGACC TCTCAGGCTC 2100 AAGCGATTCT CCCACCTCAG CCATCCAAAT AGCTGGGACC ACAGGTGTGC ACCACCACGC 2160 CCGGCTAATT TTTTGTATTT TGTCTAGATA TAGGGGCTCT CTATGTTGCT CAGGGTGGTC 2220 TCGAATTCCT GGACTCAAGC AGTCTGCCCA CCTCAGACTC CCAAAGCGGT GGAATTAGAG 2280 GCGTGAGCCC CCATGCTTGG CCTTACCTTT CTACTTTTAT AATTCTGTAT GTTATTATTT 2340 TATGAACATG AAGAAACTTT AGTAAATGTA CTTGTTTACA TAGTTATGTG AATAGATTAG 2400 ATAAACATAA AAGGAGGAGA CATACAATGG GGGAAGAAGA AGAAGTCCCC TGTAAGATGT 2460 CACTGTCTGG GTTCCAGCCC TCCCTCAGAT GTACTTTGGC TTCAATGATT GGCAACTTCT 2520 ACAGGGGCCA GTCTTTTGAA CTGGACAACC TTACAAGTAT ATGAGTATTA TTTATAGGTA 2580 GTTGTTTACA TATGAGTCGG GACCAAAGAG AACTGGATCC ACGTGAAGTC CTGTGTGTGG 2640 CTGGTCCCTA CCTGGGCAGT CTCATTTGCA CCCATAGCCC CCATCTATGG ACAGGCTGGG 2700 ACAGAGGCAG ATGGGTTAGA TCACACATAA CAATAGGGTC TATGTCATAT CCCAAGTGAA 2760 CTTGAGCCCT GTTTGGGCTC AGGAGATAGA AGACAAAATC TGTCTCCCAC GTCTGCCATG 2820 GCATCAAGGG GGAAGAGTAG ATGGTGCTTG AGAATGGTGT GAAATGGTTG CCATCTCAGG 2880 AGTAGATGGC CCGGCTCACT TCTGGTTATC TGTCACCCTG AGCCCATGAG CTGCCTTTTA 2940 GGGTACAGAT TGCCTACTTG AGGACCTTGG CCGCTCTGTA AGCATCTGAC TCATCTCAGA 3000 AATGTCAATT CTTAAACACT GTGGCAACAG GACCTAGAAT GGCTGACGCA TTAAGGTTTT 3060 CTTCTTGTGT CCTGTTCTAT TATTGTTTTA AGACCTCAGT AACCATTTCA GCCTCTTTCC 3120 AGCAAACCCT TCTCCATAGT ATTTCAGTCA TGGAAGGATC ATTTATGCAG GTAGTCATTC 3180 CAGGAGTTTT TGGTCTTTTC TGTCTCAAGG CATTGTGTGT TTTGTTCCGG GACTGGTTTG 3240 GGTGGGACAA AGTTAGAATT GCCTGAAGAT CACACATTCA GACTGTTGTG TCTGTGGAGT 3300 TTTAGGAGTG GGGGGTGACC TTTCTGGTCT TTGCACTTCC ATCCTCTCCC ACTTCCATCT 3360 GGCATCCCAC GCGTTGTCCC CTGCACTTCT GGAAGGCACA GGGTGCTGCT GCCTCCTGGT 3420 CTTTGCCTTT GCTGGGCCTT CTGTGCAGGA CGCTCAGCCT CAGGGCTCAG AAGGTGCCAG 3480 TCCGGTCCCA GGTCCCTTGT CCCTTCCACA GAGGCCTTCC TAGAAGATGC ATCTAGAGTG 3540 TCAGCCTTAT CAGTGTTTAA GATTTGTCTT TTATTTTTAA TTTTTTTGAG ACAGAATCTC 3600 ACTCTCTCGC CCAGGCTGGA GTGCAACGGT ACGATCTTGG CTCAGTGCAA CCTCCGCCTC 3660 CTGGGTTCAA GCGATTCTCG TGCCTCAGCC TCCGGAGTAG CTGGGATTGC AGGCACCCGC 3720 CACCACGCCT GGCTAATTTT TGTATTTTTA GTAGAGACGG GGTTTCACCA TGTTGGTCAG 3780 GCTGGTCTCG AACTCCTGAC CTCAGGTGAT CCACCTTGGC CTCCGAAAGT GCTGGGATTA 3840 CAGGCGTGAG CCACCAGCCA GGCCAAGCTA TTCTTTTAAA GTAAGCTTCC TGACGACATG 3900 AAATAATTGG GGGTTTTGTT GTTTAGTTAC ATTAGGCTTT GCTATATCCC CAGGCCAAAT 3960 AGCATGTGAC ACAGGACAGC CATAGTATAG TGTGTCACTC GTGGTTGGTG TCCTTTCATG 4020 CTTCTGCCCT GTCAAAGGTC CCTATTTGAA ATGTGTTATA ATACAAACAA GGAAGCACAT 4080 TGTGTACAAA ATACTTATGT ATTTATGAAT CCATGACCAA ATTAAATATG AAACCTTATA 4140 TAAAAAAAAA AAAAAAAAAA 4160 Seq ID NO : 112 DNA Sequence Nucleic Acid Accession # : Nom 147187. 1 Coding sequence : 286.. 1521 1 11 21 31 41 51 1 1 1 1 1 1 GCGCTTGCGG AGGATTGCGT TGACGAGACT CTTATTTATT GTCACCAACC TGTGGTGGAA 60 TTTGCAGTTG CACATTGGAT CTGATTCGCC CCGCCCCGAA TGACGCCTGC CCGGAGGCAG 120 TGAAAGTACA GCCGCGCCGC CCCAAGTCAG CCTGGACACA TAAATCAGCA CGCGGCCGGA 180 GAACCCCGCA ATCTCTGCGC CCACAAAATA CACCGACGAT GCCCGATCTA CTTTAAGGGC 240 TGAAACCCAC GGGCCTGAGA GACTATAAGA GCGTTCCCTA CCGCCATGGA ACAACGGGGA 300 CAGAACGCCC CGGCCGCTTC GGGGGCCCGG AAAAGGCACG GCCCAGGACC CAGGGAGGCG 360 CGGGGAGCCA GGCCTGGGCT CCGGGTCCCC AAGACCCTTG TGCTCGTTGT CGCCGCGGTC 420 CTGCTGTTGG TCTCAGCTGA GTCTGCTCTG ATCACCCAAC AAGACCTAGC TCCCCAGCAG 480 AGAGCGGCCC CACAACAAAA GAGGTCCAGC CCCTCAGAGG GATTGTGTCC ACCTGGACAC 540 CATATCTCAG AAGACGGTAG AGATTGCATC TCCTGCAAAT ATGGACAGGA CTATAGCACT 600 CACTGGAATG ACCTCCTTTT CTGCTTGCGC TGCACCAGGT GTGATTCAGG TGAAGTGGAG 660 CTAAGTCCCT GCACCACGAC CAGAAACACA GTGTGTCAGT GCGAAGAAGG CACCTTCCGG 720 GAAGAAGATT CTCCTGAGAT GTGCCGGAAG TGCCGCACAG GGTGTCCCAG AGGGATGGTC 780 AAGGTCGGTG ATTGTACACC CTGGAGTGAC ATCGAATGTG TCCACAAAGA ATCAGGCATC 840 ATCATAGGAG TCACAGTTGC AGCCGTAGTC TTGATTGTGG CTGTGTTTGT TTGCAAGTCT 900 TTACTGTGGA AGAAAGTCCT TCCTTACCTG AAAGGCATCT GCTCAGGTGG TGGTGGGGAC 960 CCTGAGCGTG TGGACAGAAG CTCACAACGA CCTGGGGCTG AGGACAATGT CCTCAATGAG 1020 ATCGTGAGTA TCTTGCAGCC CACCCAGGTC CCTGAGCAGG AAATGGAAGT CCAGGAGCCA 1080 GCAGAGCCAA CAGGTGTCAA CATGTTGTCC CCCGGGGAGT CAGAGCATCT GCTGGAACCG 1140 GCAGAAGCTG AAAGGTCTCA GAGGAGGAGG CTGCTGGTTC CAGCAAATGA AGGTGATCCC 1200 ACTGAGACTC TGAGACAGTG CTTCGATGAC TTTGCAGACT TGGTGCCCTT TGACTCCTGG 1260 GAGCCGCTCA TGAGGAAGTT GGGCCTCATG GACAATGAGA TAAAGGTGGC TAAAGCTGAG 1320 GCAGCGGGCC ACAGGGACAC CTTGTACACG ATGCTGATAA AGTGGGTCAA CAAAACCGGG 1380 CGAGATGCCT CTGTCCACAC CCTGCTGGAT GCCTTGGAGA CGCTGGGAGA GAGACTTGCC 1440 AAGCAGAAGA TTGAGGACCA CTTGTTGAGC TCTGGAAAGT TCATGTATCT AGAAGGTAAT 1500 GCAGACTCTG CCATGTCCTA AGTGTGATTC TCTTCAGGAA GTCAGACCTT CCCTGGTTTA 1560 CCTTTTTTCT GGAAAAAGCC CAACTGGACT CCAGTCAGTA GGAAAGTGCC ACAATTGTCA 1620 CATGACCGGT ACTGGAAGAA ACTCTCCCAT CCAACATCAC CCAGTGGATG GAACATCCTG 1680 TAACTTTTCA CTGCACTTGG CATTATTTTT ATAAGCTGAA TGTGATAATA AGGACACTAT 1740 GGAAATGTCT GGATCATTCC GTTTGTGCGT ACTTTGAGAT TTGGTTTGGG ATGTCATTGT 1800 TTTCACAGCA CTTTTTTATC CTAATGTAAA TGCTTTATTT ATTTATTTGG GCTACATTGT 1860 AAGATCCATC TACACAGTCG TTGTCCGACT TCACTTGATA CTATATGATA TGAACCTTTT 1920

TTGGGTGGGG GGTGCGGGGC AGTTCACTCT GTCTCCCAGG CTGGAGTGCA ATGGTGCAAT 1980 CTTGGCTCAC TATAGCCTTG ACCTCTCAGG CTCAAGCGAT TCTCCCACCT CAGCCATCCA 2040 AATAGCTGGG ACCACAGGTG TGCACCACCA CGCCCGGCTA ATTTTTTGTA TTTTGTCTAG 2100 ATATAGGGGC TCTCTATGTT GCTCAGGGTG GTCTCGAATT CCTGGACTCA AGCAGTCTGC 2160 CCACCTCAGA CTCCCAAAGC GGTGGAATTA GAGGCGTGAG CCCCCATGCT TGGCCTTACC 2220 TTTCTACTTT TATAATTCTG TATGTTATTA TTTTATGAAC ATGAAGAAAC TTTAGTAAAT 2280 GTACTTGTTT ACATAGTTAT GTGAATAGAT TAGATAAACA TAAAAGGAGG AGACATACAA 2340 TGGGGGAAGA AGAAGAAGTC CCCTGTAAGA TGTCACTGTC TGGGTTCCAG CCCTCCCTCA 2400 GATGTACTTT GGCTTCAATG ATTGGCAACT TCTACAGGGG CCAGTCTTTT GAACTGGACA 2460 ACCTTACAAG TATATGAGTA TTATTTATAG GTAGTTGTTT ACATATGAGT CGGGACCAAA 2520 GAGAACTGGA TCCACGTGAA GTCCTGTGTG TGGCTGGTCC CTACCTGGGC AGTCTCATTT 2580 GCACCCATAG CCCCCATCTA TGGACAGGCT GGGACAGAGG CAGATGGGTT AGATCACACA 2640 TAACAATAGG GTCTATGTCA TATCCCAAGT GAACTTGAGC CCTGTTTGGG CTCAGGAGAT 2700 AGAAGACAAA ATCTGTCTCC CACGTCTGCC ATGGCATCAA GGGGGAAGAG TAGATGGTGC 2760 TTGAGAATGG TGTGAAATGG TTGCCATCTC AGGAGTAGAT GGCCCGGCTC ACTTCTGGTT 2820 ATCTGTCACC CTGAGCCCAT GAGCTGCCTT TTAGGGTACA GATTGCCTAC TTGAGGACCT 2880 TGGCCGCTCT GTAAGCATCT GACTCATCTC AGAAATGTCA ATTCTTAAAC ACTGTGGCAA 2940 CAGGACCTAG AATGGCTGAC GCATTAAGGT TTTCTTCTTG TGTCCTGTTC TATTATTGTT 3000 TTAAGACCTC AGTAACCATT TCAGCCTCTT TCCAGCAAAC CCTTCTCCAT AGTATTTCAG 3060 TCATGGAAGG ATCATTTATG CAGGTAGTCA TTCCAGGAGT TTTTGGTCTT TTCTGTCTCA 3120 AGGCATTGTG TGTTTTGTTC CGGGACTGGT TTGGGTGGGA CAAAGTTAGA ATTGCCTGAA 3180 GATCACACAT TCAGACTGTT GTGTCTGTGG AGTTTTAGGA GTGGGGGGTG ACCTTTCTGG 3240 TCTTTGCACT TCCATCCTCT CCCACTTCCA TCTGGCATCC CACGCGTTGT CCCCTGCACT 3300 TCTGGAAGGC ACAGGGTGCT GCTGCCTCCT GGTCTTTGCC TTTGCTGGGC CTTCTGTGCA 3360 GGACGCTCAG CCTCAGGGCT CAGAAGGTGC CAGTCCGGTC CCAGGTCCCT TGTCCCTTCC 3420 ACAGAGGCCT TCCTAGAAGA TGCATCTAGA GTGTCAGCCT TATCAGTGTT TAAGATTTGT 3480 CTTTTATTTT TAATTTTTTT GAGACAGAAT CTCACTCTCT CGCCCAGGCT GGAGTGCAAC 3540 GGTACGATCT TGGCTCAGTG CAACCTCCGC CTCCTGGGTT CAAGCGATTC TCGTGCCTCA 3600 GCCTCCGGAG TAGCTGGGAT TGCAGGCACC CGCCACCACG CCTGGCTAAT TTTTGTATTT 3660 TTAGTAGAGA CGGGGTTTCA CCATGTTGGT CAGGCTGGTC TCGAACTCCT GACCTCAGGT 3720 GATCCACCTT GGCCTCCGAA AGTGCTGGGA TTACAGGCGT GAGCCACCAG CCAGGCCAAG 3780 CTATTCTTTT AAAGTAAGCT TCCTGACGAC ATGAAATAAT TGGGGGTTTT GTTGTTTAGT 3840 TACATTAGGC TTTGCTATAT CCCCAGGCCA AATAGCATGT GACACAGGAC AGCCATAGTA 3900 TAGTGTGTCA CTCGTGGTTG GTGTCCTTTC ATGCTTCTGC CCTGTCAAAG GTCCCTATTT 3960 GAAATGTGTT ATAATACAAA CAAGGAAGCA CATTGTGTAC AAAATACTTA TGTATTTATG 4020 AATCCATGAC CAAATTAAAT ATGAAACCTT ATATAAAAAA AAAAAAAAAA AAA 4073 Seq ID NO : 113 DNA Sequence Nucleic Acid Accession # : Nom 002011. 2 Coding sequence : 157.. 2565 1 11 21 31 41 51 1 1 1 1 1 1 CCGAGGAGCG CTCGGGCTGT CTGCGGACCC TGCCGCGTGC AGGGGTCGCG GCCGGCTGGA 60 GCTGGGAGTG AGGCGGCGGA GGAGCCAGGT GAGGAGGAGC CAGGAAGGCA GTTGGTGGGA 120 AGTCCAGCTT GGGTCCCTGA GAGCTGTGAG AAGGAGATGC GGCTGCTGCT GGCCCTGTTG 180 GGGGTCCTGC TGAGTGTGCC TGGGCCTCCA GTCTTGTCCC TGGAGGCCTC TGAGGAAGTG 240 GAGCTTGAGC CCTGCCTGGC TCCCAGCCTG GAGCAGCAAG AGCAGGAGCT GACAGTAGCC 300 CTTGGGCAGC CTGTGCGGCT GTGCTGTGGG CGGGCTGAGC GTGGTGGCCA CTGGTACAAG 360 GAGGGCAGTC GCCTGGCACC TGCTGGCCGT GTACGGGGCT GGAGGGGCCG CCTAGAGATT 420 GCCAGCTTCC TACCTGAGGA TGCTGGCCGC TACCTCTGCC TGGCACGAGG CTCCATGATC 480 GTCCTGCAGA ATCTCACCTT GATTACAGGT GACTCCTTGA CCTCCAGCAA CGATGATGAG 540 GACCCCAAGT CCCATAGGGA CCTCTCGAAT AGGCACAGTT ACCCCCAGCA AGCACCCTAC 600 TGGACACACC CCCAGCGCAT GGAGAAGAAA CTGCATGCAG TACCTGCGGG GAACACCGTC 660 AAGTTCCGCT GTCCAGCTGC AGGCAACCCC ACGCCCACCA TCCGCTGGCT TAAGGATGGA 720 CAGGCCTTTC ATGGGGAGAA CCGCATTGGA GGCATTCGGC TGCGCCATCA GCACTGGAGT 780 CTCGTGATGG AGAGCGTGGT GCCCTCGGAC CGCGGCACAT ACACCTGCCT GGTAGAGAAC 840 GCTGTGGGCA GCATCCGCTA TAACTACCTG CTAGATGTGC TGGAGCGGTC CCCGCACCGG 900 CCCATCCTGC AGGCCGGGCT CCCGGCCAAC ACCACAGCCG TGGTGGGCAG CGACGTGGAG 960 CTGCTGTGCA AGGTGTACAG CGATGCCCAG CCCCACATCC AGTGGCTGAA GCACATCGTC 1020 ATCAACGGCA GCAGCTTCGG AGCCGACGGT TTCCCCTATG TGCAAGTCCT AAAGACTGCA 1080 GACATCAATA GCTCAGAGGT GGAGGTCCTG TACCTGCGGA ACGTGTCAGC CGAGGACGCA 1140 GGCGAGTACA CCTGCCTCGC AGGCAATTCC ATCGGCCTCT CCTACCAGTC TGCCTGGCTC 1200 ACGGTGCTGC CAGAGGAGGA CCCCACATGG ACCGCAGCAG CGCCCGAGGC CAGGTATACG 1260 GACATCATCC TGTACGCGTC GGGCTCCCTG GCCTTGGCTG TGCTCCTGCT GCTGGCCGGG 1320 CTGTATCGAG GGCAGGCGCT CCACGGCCGG CACCCCCGCC CGCCCGCCAC TGTGCAGAAG 1380 CTCTCCCGCT TCCCTCTGGC CCGACAGTTC TCCCTGGAGT CAGGCTCTTC CGGCAAGTCA 1440 AGCTCATCCC TGGTACGAGG CGTGCGTCTC TCCTCCAGCG GCCCCGCCTT GCTCGCCGGC 1500 CTCGTGAGTC TAGATCTACC TCTCGACCCA CTATGGGAGT TCCCCCGGGA CAGGCTGGTG 1560 CTTGGGAAGC CCCTAGGCGA GGGCTGCTTT GGCCAGGTAG TACGTGCAGA GGCCTTTGGC 1620 ATGGACCCTG CCCGGCCTGA CCAAGCCAGC ACTGTGGCCG TCAAGATGCT CAAAGACAAC 1680 GCCTCTGACA AGGACCTGGC CGACCTGGTC TCGGAGATGG AGGTGATGAA GCTGATCGGC 1740 CGACACAAGA ACATCATCAA CCTGCTTGGT GTCTGCACCC AGGAAGGGCC CCTGTACGTG 1800 ATCGTGGAGT GCGCCGCCAA GGGAAACCTG CGGGAGTTCC TGCGGGCCCG GCGCCCCCCA 1860 GGCCCCGACC TCAGCCCCGA CGGTCCTCGG AGCAGTGAGG GGCCGCTCTC CTTCCCAGTC 1920 CTGGTCTCCT GCGCCTACCA GGTGGCCCGA GGCATGCAGT ATCTGGAGTC CCGGAAGTGT 1980 ATCCACCGGG ACCTGGCTGC CCGCAATGTG CTGGTGACTG AGGACAATGT GATGAAGATT 2040 GCTGACTTTG GGCTGGCCCG CGGCGTCCAC CACATTGACT ACTATAAGAA AACCAGCAAC 2100 GGCCGCCTGC CTGTGAAGTG GATGGCGCCC GAGGCCTTGT TTGACCGGGT GTACACACAC 2160 CAGAGTGACG TGTGGTCTTT TGGGATCCTG CTATGGGAGA TCTTCACCCT CGGGGGCTCC 2220 CCGTATCCTG GCATCCCGGT GGAGGAGCTG TTCTCGCTGC TGCGGGAGGG ACATCGGATG 2280 GACCGACCCC CACACTGCCC CCCAGAGCTG TACGGGCTGA TGCGTGAGTG CTGGCACGCA 2340 GCGCCCTCCC AGAGGCCTAC CTTCAAGCAG CTGGTGGAGG CGCTGGACAA GGTCCTGCTG 2400 GCCGTCTCTG AGGAGTACCT CGACCTCCGC CTGACCTTCG GACCCTATTC CCCCTCTGGT 2460 GGGGACGCCA GCAGCACCTG CTCCTCCAGC GATTCTGTCT TCAGCCACGA CCCCCTGCCA 2520

TTGGGATCCA GCTCCTTCCC CTTCGGGTCT GGGGTGCAGA CATGAGCAAG GCTCAAGGCT 2580 GTGCAGGCAC ATAGGCTGGT GGCCTTGGGC CTTGGGGCTC AGCCACAGCC TGACACAGTG 2640 CTCGACCTTG ATAGCATGGG GCCCCTGGCC CAGAGTTGCT GTGCCGTGTC CAAGGGCCGT 2700 GCCCTTGCCC TTGGAGCTGC CGTGCCTGTG TCCTGATGGC CCAAATGTCA GGGTTCTGCT 2760 CGGCTTCTTG GACCATGGCG CTTAGTCCCC ATCCCGGGTT TGGCTGAGCC TGGCTGGAGA 2820 GCTGCTATGC TAAACCTCCT GCCTCCCAAT ACCAGCAGGA GGTTCTGGGC CTCTGAACCC 2880 CCTTTCCCCA CACCTCCCCC TGCTGCTGCT GCCCCAGCGT CTTGACGGGA GCATTGGCCC 2940 CTGAGCCCAG AGAAGCTGGA AGCCTGCCGA AAACAGGAGC AAATGGCGTT TTATAAATTA 3000 TTTTTTTGAA ATAAA 3015 Seq ID NO : 114 DNA Sequence Nucleic Acid Accession # : NM 022963. 1 Coding sequence : 157.. 2445 1 11 21 31 41 51 CCGAGGAGCG CTCGGGCTGT CTGCGGACCC TGCCGCGTGC AGGGGTCGCG GCCGGCTGGA 60 GCTGGGAGTG AGGCGGCGGA GGAGCCAGGT GAGGAGGAGC CAGGAAGGCA GTTGGTGGGA 120 AGTCCAGCTT GGGTCCCTGA GAGCTGTGAG AAGGAGATGC GGCTGCTGCT GGCCCTGTTG 180 GGGGTCCTGC TGAGTGTGCC TGGGCCTCCA GTCTTGTCCC TGGAGGCCTC TGAGGAAGTG 240 GAGCTTGAGC CCTGCCTGGC TCCCAGCCTG GAGCAGCAAG AGCAGGAGCT GACAGTAGCC 300 CTTGGGCAGC CTGTGCGGCT GTGCTGTGGG CGGGCTGAGC GTGGTGGCCA CTGGTACAAG 360 GAGGGCAGTC GCCTGGCACC TGCTGGCCGT GTACGGGGCT GGAGGGGCCG CCTAGAGATT 420 GCCAGCTTCC TACCTGAGGA TGCTGGCCGC TACCTCTGCC TGGCACGAGG CTCCATGATC 480 GTCCTGCAGA ATCTCACCTT GATTACAGGT GACTCCTTGA CCTCCAGCAA CGATGATGAG 540 GACCCCAAGT CCCATAGGGA CCTCTCGAAT AGGCACAGTT ACCCCCAGCA AGCACCCTAC 600 TGGACACACC CCCAGCGCAT GGAGAAGAAA CTGCATGCAG TACCTGCGGG GAACACCGTC 660 AAGTTCCGCT GTCCAGCTGC AGGCAACCCC ACGCCCACCA TCCGCTGGCT TAAGGATGGA 720 CAGGCCTTTC ATGGGGAGAA CCGCATTGGA GGCATTCGGC TGCGCCATCA GCACTGGAGT 780 CTCGTGATGG AGAGCGTGGT GCCCTCGGAC CGCGGCACAT ACACCTGCCT GGTAGAGAAC 840 GCTGTGGGCA GCATCCGCTA TAACTACCTG CTAGATGTGC TGGAGCGGTC CCCGCACCGG 900 CCCATCCTGC AGGCCGGGCT CCCGGCCAAC ACCACAGCCG TGGTGGGCAG CGACGTGGAG 960 CTGCTGTGCA AGGTGTACAG CGATGCCCAG CCCCACATCC AGTGGCTGAA GCACATCGTC 1020 ATCAACGGCA GCAGCTTCGG AGCCGACGGT TTCCCCTATG TGCAAGTCCT AAAGACTGCA 1080 GACATCAATA GCTCAGAGGT GGAGGTCCTG TACCTGCGGA ACGTGTCAGC CGAGGACGCA 1140 GGCGAGTACA CCTGCCTCGC AGGCAATTCC ATCGGCCTCT CCTACCAGTC TGCCTGGCTC 1200 ACGGTGCTGC CAGGTACTGG GCGCATCCCC CACCTCACAT GTGACAGCCT GACTCCAGCA 1260 GGCAGAACCA AGTCTCCCAC TTTGCAGTTC TCCCTGGAGT CAGGCTCTTC CGGCAAGTCA 1320 AGCTCATCCC TGGTACGAGG CGTGCGTCTC TCCTCCAGCG GCCCCGCCTT GCTCGCCGGC 1380 CTCGTGAGTC TAGATCTACC TCTCGACCCA CTATGGGAGT TCCCCCGGGA CAGGCTGGTG 1440 CTTGGGAAGC CCCTAGGCGA GGGCTGCTTT GGCCAGGTAG TACGTGCAGA GGCCTTTGGC 1500 ATGGACCCTG CCCGGCCTGA CCAAGCCAGC ACTGTGGCCG TCAAGATGCT CAAAGACAAC 1560 GCCTCTGACA AGGACCTGGC CGACCTGGTC TCGGAGATGG AGGTGATGAA GCTGATCGGC 1620 CGACACAAGA ACATCATCAA CCTGCTTGGT GTCTGCACCC AGGAAGGGCC CCTGTACGTG 1680 ATCGTGGAGT GCGCCGCCAA GGGAAACCTG CGGGAGTTCC TGCGGGCCCG GCGCCCCCCA 1740 GGCCCCGACC TCAGCCCCGA CGGTCCTCGG AGCAGTGAGG GGCCGCTCTC CTTCCCAGTC 1800 CTGGTCTCCT GCGCCTACCA GGTGGCCCGA GGCATGCAGT ATCTGGAGTC CCGGAAGTGT 1860 ATCCACCGGG ACCTGGCTGC CCGCAATGTG CTGGTGACTG AGGACAATGT GATGAAGATT 1920 GCTGACTTTG GGCTGGCCCG CGGCGTCCAC CACATTGACT ACTATAAGAA AACCAGCAAC 1980 GGCCGCCTGC CTGTGAAGTG GATGGCGCCC GAGGCCTTGT TTGACCGGGT GTACACACAC 2040 CAGAGTGACG TGTGGTCTTT TGGGATCCTG CTATGGGAGA TCTTCACCCT CGGGGGCTCC 2100 CCGTATCCTG GCATCCCGGT GGAGGAGCTG TTCTCGCTGC TGCGGGAGGG ACATCGGATG 2160 GACCGACCCC CACACTGCCC CCCAGAGCTG TACGGGCTGA TGCGTGAGTG CTGGCACGCA 2220 GCGCCCTCCC AGAGGCCTAC CTTCAAGCAG CTGGTGGAGG CGCTGGACAA GGTCCTGCTG 2280 GCCGTCTCTG AGGAGTACCT CGACCTCCGC CTGACCTTCG GACCCTATTC CCCCTCTGGT 2340 GGGGACGCCA GCAGCACCTG CTCCTCCAGC GATTCTGTCT TCAGCCACGA CCCCCTGCCA 2400 TTGGGATCCA GCTCCTTCCC CTTCGGGTCT GGGGTGCAGA CATGAGCAAG GCTCAAGGCT 2460 GTGCAGGCAC ATAGGCTGGT GGCCTTGGGC CTTGGGGCTC AGCCACAGCC TGACACAGTG 2520 CTCGACCTTG ATAGCATGGG GCCCCTGGCC CAGAGTTGCT GTGCCGTGTC CAAGGGCCGT 2580 GCCCTTGCCC TTGGAGCTGC CGTGCCTGTG TCCTGATGGC CCAAATGTCA GGGTTCTGCT 2640 CGGCTTCTTG GACCATGGCG CTTAGTCCCC ATCCCGGGTT TGGCTGAGCC TGGCTGGAGA 2700 GCTGCTATGC TAAACCTCCT GCCTCCCAAT ACCAGCAGGA GGTTCTGGGC CTCTGAACCC 2760 CCTTTCCCCA CACCTCCCCC TGCTGCTGCT GCCCCAGCGT CTTGACGGGA GCATTGGCCC 2820 CTGAGCCCAG AGAAGCTGGA AGCCTGCCGA AAACAGGAGC AAATGGCGTT TTATAAATTA 2880 TTTTTTTGAA ATAAA 2895 Seq ID NO : 15 DNA Sequence Nucleic Acid Accession # : NM 002845. 2 Coding sequence : 1.. 4359 1 11 21 31 41 51 ( ATGAGGGGAC TTGGGACTTG CCTGGCGACT TTGGCCGGAC TTTTGCTAAC TGCGGCGGGC 60 GAGACGTTCT CAGGTGGCTG CCTCTTTGAT GAGCCGTATA GCACATGTGG ATATAGTCAA 120 TCTGAAGGTG ATGACTTCAA TTGGGAGCAA GTGAACACCT TGACTAAACC GACTTCTGAT 180 CCATGGATGC CATCAGGTTC TCTCATGCTG GTGAATGCCT CTGGGAGACC TGAGGGGCAG 240 AGAGCCCACC TGCTCTTACC CCAACTTAAG GAAAATGACA CCCACTGCAT CGATTTTCAC 300 TATTTTGTGT CCAGCAAGAG TAATTCTCCT CCGGGGTTAC TCAATGTCTA CGTGAAGGTC 360 AATAACGGGC CACTGGGGAA TCCTATCTGG AATATATCTG GAGACCCAAC ACGTACATGG 420 AACAGGGCAG AACTGGCCAT TAGTACTTTC TGGCCTAACT TTTATCAGGT GATTTTTGAA 480 GTGATAACTT CTGGACATCA AGGCTATCTC GCTATCGATG AGGTGAAGGT GTTAGGACAT 540 CCATGTACCA GGACTCCTCA CTTCCTGCGG ATTCAGAATG TGGAAGTTAA TGCTGGCCAG 600 TTTGCTACCT TCCAGTGCAG TGCCATCGGC AGGACCGTGG CAGGAGACAG GCTCTGGTTA 660 CAGGGCATTG ATGTGCGAGA TGCTCCTCTG AAGGAAATCA AGGTGACCAG CTCCCGACGC 720 TTCATTGCTT CATTTAATGT TGTGAATACC ACCAAACGAG ATGCTGGAAA GTACCGCTGC 780 ATGATTCGCA CTGAAGGAGG TGTTGGAATA TCAAACTATG CAGAGTTGGT AGTTAAAGAA 840

CCACCCGTTC CTATTGCCCC ACCTCAGCTC GCCTCTGTAG GAGCCACCTA CCTGTGGATA 900 CAGCTCAACG CCAACTCCAT CAATGGGGAT GGGCCCATTG TGGCCCGAGA GGTGGAGTAC 960 TGCACGGCCA GTGGGAGCTG GAATGACCGG CAGCCAGTCG ATTCCACGAG CTATAAAATT 1020 GGACACCTTG ACCCAGATAC AGAATATGAG ATTAGTGTGC TCCTGACCAG GCCAGGGGAG 1080 GGTGGCACTG GCTCTCCTGG TCCAGCTCTC AGGACAAGAA CAAAGTGTGC TGATCCCATG 1140 CGAGGCCCAA GAAAACTAGA AGTAGTGGAG GTCAAATCTC GGCAAATCAC TATCCGCTGG 1200 GAGCCATTTG GATATAATGT AACTCGTTGC CACAGTTATA ATCTCACTGT CCACTACTGT 1260 TACCAAGTTG GAGGACAAGA ACAAGTGCGA GAAGAAGTAA GCTGGGATAC AGAAAATTCA 1320 CACCCTCAAC ACACGATCAC TAACCTGTCA CCATACACCA ATGTCAGTGT GAAACTGATC 1380 CTCATGAACC CAGAGGGCCG GAAGGAAAGC CAAGAACTCA TAGTGCAGAC AGATGAAGAC 1440 CTCCCAGGTG CTGTTCCCAC TGAATCCATA CAAGGAAGTA CCTTTGAAGA GAAGATATTT 1500 CTTCAGTGGA GAGAACCAAC TCAAACATAT GGTGTAATCA CTTTATATGA GATCACCTAC 1560 AAAGCAGTCA GTTCCTTTGA CCCAGAAATA GATTTATCCA ATCAGAGTGG AAGAGTTTCA 1620 AAGCTGGGAA ATGAAACCCA TTTTCTGTTT TTTGGACTGT ATCCGGGGAC CACATACTCC 1680 TTTACCATCC GAGCTAGCAC AGCTAAGGGT TTTGGGCCTC CAGCAACAAA CCAGTTCACC 1740 ACCAAAATAT CAGCACCCTC TATGCCAGCT TATGAACTTG AGACACCTTT GAATCAAACT 1800 GACAATACCG TGACAGTCAT GCTGAAACCT GCCCACAGCA GAGGAGCACC TGTCAGTGTC 1860 TATCAAATAG TTGTTGAGGA AGAACGTCCT CGAAGAACTA AAAAGACGAC AGAAATCTTA 1920 AAGTGCTACC CAGTGCCAAT TCACTTCCAG AATGCTTCTC TGCTGAACTC ACAGTACTAC 1980 TTTGCTGCAG AATTTCCTGC AGACAGCCTC CAAGCTGCGC AGCCTTTTAC AATTGGTGAT 2040 AATAAGACAT ATAATGGATA CTGGAACACT CCCCTTCTCC CCTATAAAAG CTACAGAATT 2100 TATTTCCAAG CTGCTAGTAG AGCCAATGGG GAAACCAAAA TAGACTGTGT CCAAGTGGCC 2160 ACAAAAGGAG CTGCCACTCC GAAACCAGTC CCAGAACCCG AGAAACAGAC AGACCATACA 2220 GTTAAAATTG CTGGAGTCAT CGCGGGCATC TTGCTGTTCG TGATTATATT TCTTGGAGTT 2280 GTGTTGGTAA TGAAGAAAAG GAAACTGGCC AAGAAGCGGA AAGAGACCAT GAGCAGCACC 2340 CGACAGGAGA TGACTGTGAT GGTGAACTCA ATGGACAAGA GCTATGCTGA GCAGGGCACA 2400 AACTGCGACG AGGCTTTCTC ATTCATGGAC ACGCACAATC TGAATGGGAG ATCTGTGTCT 2460 TCACCATCGT CCTTCACAAT GAAAACAAAT ACACTGAGCA CATCGGTGCC TAATTCCTAT 2520 TACCCAGATG AAACCCACAC AATGGCCAGC GATACCAGCA GCCTGGTGCA GTCCCATACT 2580 TACAAGAAGC GAGAGCCGGC CGACGTGCCC TATCAGACTG GGCAGCTCCA CCCCGCCATC 2640 CGGGTGGCAG ACCTCCTTCA GCACATCACA CAGATGAAGT GTGCGGAGGG CTACGGCTTC 2700 AAGGAGGAAT ACGAGAGCTT CTTTGAAGGG CAGTCTGCAC CATGGGACTC GGCTAAGAAA 2760 GATGAGAACA GAATGAAGAA CAGATACGGG AATATCATTG CATACGATCA TTCCCGAGTG 2820 AGGCTGCAGA CAATAGAAGG AGACACAAAC TCAGACTATA TCAATGGCAA TTATATCGAT 2880 GGTTATCATC GACCCAATCA TTACATTGCT ACCCAAGGGC CAATGCAGGA AACCATCTAT 2940 GACTTCTGGA GGATGGTGTG GCACGAAAAC ACTGCAAGTA TCATCATGGT GACCAATCTT 3000 GTGGAAGTGG GAAGGGTCAA ATGCTGCAAA TACTGGCCAG ATGACACAGA GATATATAAA 3060 GACATTAAAG TTACCCTAAT AGAAACAGAA CTACTGGCAG AATATGTGAT AAGAACATTT 3120 GCTGTTGAAA AGAGAGGTGT GCATGAAATC CGAGAGATCA GACAGTTTCA CTTCACTGGC 3180 TGGCCGGATC ATGGGGTCCC CTACCATGCC ACCGGCCTGC TGGGATTCGT GCGGCAAGTC 3240 AAGTCCAAGA GCCCGCCCAG TGCAGGCCCA CTGGTGGTGC ACTGCAGTGC TGGTGCAGGG 3300 AGGACTGGCT GTTTCATCGT CATTGATATC ATGTTGGACA TGGCCGAAAG GGAAGGGGTC 3360 GTAGACATCT ACAACTGCGT CAGGGAGCTG CGGTCACGGA GGGTGAACAT GGTGCAAACA 3420 GAGGAGCAGT ATGTGTTTAT CCACGATGCG ATCCTGGAAG CCTGTCTTTG TGGGGACACC 3480 TCTGTGCCTG CTTCCCAAGT TAGGTCTCTG TATTATGACA TGAACAAACT GGATCCACAG 3540 ACAAACTCAA GCCAGATTAA AGAGGAATTC CGGACGCTAA ACATGGTGAC ACCAACGCTG 3600 CGAGTAGAGG ACTGCAGCAT CGCACTGTTG CCCCGGAACC ATGAGAAAAA CCGGTGCATG 3660 GACATCCTGC CCCCAGACCG CTGCCTGCCC TTCCTCATCA CCATCGATGG GGAGAGCAGC 3720 AACTACATCA ATGCTGCCCT CATGGACAGC TATAAACAGC CTTCAGCTTT TATAGTCACC 3780 CAGCATCCTT TGCCAAACAC AGTGAAAGAC TTTTGGAGAC TGGTCCTGGA TTATCACTGC 3840 ACATCCGTAG TTATGCTAAA TGATGTGGAT CCTGCCCAGT TGTGTCCACA GTACTGGCCA 3900 GAAAACGGAG TACACAGACA CGGCCCCATC CAGGTGGAAT TTGTCTCTGC TGACCTGGAA 3960 GAGGACATCA TCAGCAGGAT ATTCCGCATT TACAATGCCG CCAGACCCCA AGATGGATAT 4020 CGGATGGTGC AGCAATTCCA GTTCCTGGGC TGGCCGATGT ACAGGGACAC ACCAGTGTCT 4080 AAGCGCTCCT TCTTGAAGCT CATTCGCCAG GTGGACAAGT GGCAAGAGGA ATACAATGGC 4140 GGGGAAGGCC CGACCGTTGT GCACTGCTTG AACGGGGGAG GCCGCAGTGG GACGTTCTGC 4200 GCCATCAGCA TCGTATGTGA GATGCTCCGG CACCAGAGAA CCGTGGATGT CTTTCACGCT 4260 GTGAAGACAC TGAGGAACAA CAAGCCCAAC ATGGTCGACC TCCTGGATCA GTACAAGTTC 4320 TGCTACGAGG TGGCCCTGGA ATACTTGAAT TCTGGCTGAT GGTGTAAACA GCTCTGCAAA 4380 CAATCCCTTT CATACCACAA AGCCAAGACG TTCCATGGTA TTTGTGCAAA AGAGATGAAG 4440 ACTTCTCAAT ATGCTTATTT TGCTTTGCAT AATTGGCTCT TTTTAAGAGC CCAAGAAAGT 4500 GTTTCTAAAA TTGCTTGCAC TGCCCAATCC CAGTAATGCT GCTGCCTGAC AGAAACACAC 4560 ACACAGCCAC AGTTGCCAAA TCCCGTACTC CTTGCCACCG GCTTTCTAGA GCAGCGTAGA 4620 CAGCTGGTAA ACTGAAGAGC ACAACTATAT TCTTATGAAG GAATTTGTAC CTTTGGGGTA 4680 TTATTTTGTG GCCCGTGACC CTCGTTATTG TTACAGCTGA GTGTATGTTT TTGTTCTGTG 4740 GAGAATGCTA TCTGGCATTA TGGTAATATA TTATTTTAGG TAATATTTGT ACTTTAACAT 4800 GTTGCATAAT ATATGCTTAT GTAGCTTTCC AGGACTAACA GATAAATGTG TAATGAACAA 4860 AGATATGTTG TATGAGTCGT CGTTTCTGTC AGATTTGTAT TGTTTCCAAG GGAAAAGCTT 4920 GGGGGAGGAC TCAGTTCACA AAATGCAAAA CTCAACGATC AGATTCACGG ACCCAGAGCT 4980 TTTCCATGTG TTTATATTGT AAATATTTTT GATTTCATCA AATTATTTAT TCATTAAAAG 5040 AAATTTTTGT GAAAAAAAAA AAAAA 5065 Seq ID NO : 116 DNA Sequence Nucleic Acid Accession # : Nom 016551. 1 Coding sequence : 38.. 1750 1 11 21 31 41 51 1 1 1 1 1 1 CCAGCCCTGG CGTGGGCCCA GCCCGGCCCA GGCAGCAATG GGGTTCCTGC AGCTGCTGGT 60 CGTAGCGGTG CTGGCATCCG AACACCGGGT GGCTGGTGCA GCCGAGGTCT TCGGGAATTC 120 CAGCGAGGGT CTTATTGAAT TTTCTGTGGG GAAATTTAGA TACTTCGAGC TCAATAGGCC 180 CTTTCCAGAG GAAGCTATTT TGCATGATAT TTCAAGCAAT GTGACTTTTC TTATTTTCCA 240 AATACACTCA CAGTATCAGA ATACAACTGT TTCCTTTTCT CCGACTCTCC TTTCCAATTC 300 CTCGGAAACA GGCACTGCCA GTGGACTGGT TTTCATCCTT AGACCAGAGC AGAGTACATG 360 CACTTGGTAC TTGGGGACTT CAGGCATACA GCCTGTCCAG AATATGGCTA TCCTACTCTC 420

CTACTCAGAA AGAGATCCTG TCCCTGGAGG CTGTAATTTG GAGTTCGATT TAGATATTGA 480 TCCCAACATT TACTTGGAGT ATAATTTCTT TGAAACGACT ATCAAGTTTG CCCCAGCAAA 540 CCTAGGCTAT GCGAGAGGCG TAGATCCCCC ACCATGTGAC GCTGGGACAG ACCAGGACTC 600 CAGGTGGAGG TTGCAGTATG ATGTCTATCA GTATTTTCTG CCTGAGAATG ACCTCACTGA 660 GGAGATGTTG CTGAAGCATC TGCAGAGGAT GGTCAGTGTG CCCCAGGTGA AGGCCAGTGC 720 TCTCAAGGTG GTTACCCTAA CAGCTAATGA TAAGACAAGT GTTTCCTTCT CCTCCCTCCC 780 GGGACAAGGT GTCATATACA ATGTCATTGT TTGGGACCCG TTTCTAAATA CATCTGCTGC 840 CTACATTCCT GCTCACACAT ACGCTTGCAG CTTTGAGGCA GGAGAGGGTA GTTGTGCTTC 900 CCTAGGAAGA GTGTCTTCCA AAGTGTTCTT CACTCTTTTT GCCCTGCTTG GTTTCTTCAT 960 TTGTTTCTTT GGACACAGAT TCTGGAAAAC AGAATTATTC TTCATAGGCT TTATCATCAT 1020 GGGATTCTTC TTTTATATAC TGATTACAAG ACTGACACCT ATCAAGTATG ATGTGAATCT 1080 GATTCTGACA GCTGTCACTG GAAGCGTCGG TGGAATGTTC TTGGTAGCTG TGTGGTGGCG 1140 ATTTGGAATC CTCTCGATCT GCATGCTCTG TGTTGGACTA GTGCTGGGGT TCCTCATCTC 1200 GTCAGTGACT TTCTTTACTC CACTGGGAAA CCTAAAGATT TTTCATGATG ATGGTGTATT 1260 CTGGGTCACT TTCTCTTGCA TAGCTATCCT CATTCCAGTA GTTTTCATGG GCTGCCTAAG 1320 AATACTGAAC ATACTGACTT GTGGAGTCAT TGGCTCCTAT TCGGTGGTTT TAGCCATTGA 1380 CAGTTACTGG TCCACAAGCC TTTCCTACAT CACTTTGAAC GTACTCAAGA GAGCGCTCAA 1440 CAAGGATTTC CACAGAGCTT TCACAAATGT GCCTTTTCAA ACTAATGACT TCATTATCCT 1500 GGCAGTATGG GGCATGCTGG CTGTAAGTGG AATTACGTTA CAGATTCGAA GAGAGAGAGG 1560 ACGACCGTTC TTCCCTCCCC ACCCATACAA GTTATGGAAG CAAGAGAGAG AGCGCCGAGT 1620 GACAAACATT CTGGACCCTA GCTACCACAT TCCTCCATTG AGAGAGAGGC TCTATGGCCG 1680 ATTAACCCAG ATTAAAGGGC TCTTCCAGAA GGAGCAGCCA GCTGGAGAGA GAACGCCTTT 1740 GCTTCTGTAG ATGCCCAGGG GCTTGGTCAG TGTGCCTCAG CTTTGGAGTT CATGCCTGGA 1800 GTGGTTCAAC AGTCTCTGGT GCAAGTCTAA TAAGAGATCA GGCATATATA TCTGTTCTTT 1860 GCATAATATT ATGGTGCCCT TATTGATATA TGGTAAGGGT GTACTAGGGG ATTAGGATGA 1920 TTGTAAGAGA ATGAGAAAGA TGACCAAAAG GTTGGTGGTA GGGAGGCTTT TTCTTATTTC 1980 CAAATACTTG AGAAATTACC TTTTGGTTTA CAAATCTATG ATCAACTTAT TCCATTAAAT 2040 AGATACATTA AAAAAATTAA AAACTGCAAA AAAAAAAAAA AAACTGGTGT TTCTTTTTAT 2100 AACCCCTTGA AACAAGTCTC TCACCTGAGC CTGTCTAAAC TTTCGGAGGG AGTTTATTAT 2160 TGAGTCTTTA TCTGTGACAG TATTTGGAGA TTTAGGGATT TGATACTTAG GCCTTTGAAT 2220 TTTAGAATAC AAAAAGAGAA GCAAGCCAGA CATGGTGGCT CACACCTGTA ATCCCAATAC 2280 TGGGAAGCCA AGGTGGGAGT ATCGCTTGAG CCCAGGAGTT TGAGACCGAC ATGGGCAACA 2340 TGACAAGACC CCATCTCTAC AAAAAAAATT AAAAAATTAG CCAGGCATGG TGGCACATGC 2400 CTACTCCCAG CTCCCAAGGA GACTGAGATG GGAGGATCCC TGGAGCCCTG AAGATTGAGG 2460 CTACAGTGAG CCTTGATTGT GTCACTGCAC TCCAGCTTGG GTGACAGAGA CCCTGTCTCG 2520 AGAAATT 2527 Seq ID NO : 117 DNA Sequence Nucleic Acid Accession # : Nom 003820. 1 Coding sequence : 294.. 1145 1 11 21 31 41 51 CCTTCATACC GGCCCTTCCC CTCGGCTTTG CCTGGACAGC TCCTGCCTCC CGCAGGGCCC 60 ACCTGTGTCC CCCAGCGCCG CTCCACCCAG CAGGCCTGAG CCCCTCTCTG CTGCCAGACA 120 CCCCCTGCTG CCCACTCTCC TGCTGCTCGG GTTCTGAGGC ACAGCTTGTC ACACCGAGGC 180 GGATTCTCTT TCTCTTTCTC TTCTGGCCCA CAGCCGCAGC AATGGCGCTG AGTTCCTCTG 240 CTGGAGTTCA TCCTGCTAGC TGGGTTCCCG AGCTGCCGGT CTGAGCCTGA GGCATGGAGC 300 CTCCTGGAGA CTGGGGGCCT CCTCCCTGGA GATCCACCCC CAGAACCGAC GTCTTGAGGC 360 TGGTGCTGTA TCTCACCTTC CTGGGAGCCC CCTGCTACGC CCCAGCTCTG CCGTCCTGCA 420 AGGAGGACGA GTACCCAGTG GGCTCCGAGT GCTGCCCCAA GTGCAGTCCA GGTTATCGTG 480 TGAAGGAGGC CTGCGGGGAG CTGACGGGCA CAGTGTGTGA ACCCTGCCCT CCAGGCACCT 540 ACATTGCCCA CCTCAATGGC CTAAGCAAGT GTCTGCAGTG CCAAATGTGT GACCCAGCCA 600 TGGGCCTGCG CGCGAGCCGG AACTGCTCCA GGACAGAGAA CGCCGTGTGT GGCTGCAGCC 660 CAGGCCACTT CTGCATCGTC CAGGACGGGG ACCACTGCGC CGCGTGCCGC GCTTACGCCA 720 CCTCCAGCCC GGGCCAGAGG GTGCAGAAGG GAGGCACCGA GAGTCAGGAC ACCCTGTGTC 780 AGAACTGCCC CCCGGGGACC TTCTCTCCCA ATGGGACCCT GGAGGAATGT CAGCACCAGA 840 CCAAGTGCAG CTGGCTGGTG ACGAAGGCCG GAGCTGGGAC CAGCAGCTCC CACTGGGTAT 900 GGTGGTTTCT CTCAGGGAGC CTCGTCATCG TCATTGTTTG CTCCACAGTT GGCCTAATCA 960 TATGTGTGAA AAGAAGAAAG CCAAGGGGTG ATGTAGTCAA GGTGATCGTC TCCGTCCAGC 1020 GGAAAAGACA GGAGGCAGAA GGTGAGGCCA CAGTCATTGA GGCCCTGCAG GCCCCTCCGG 1080 ACGTCACCAC GGTGGCCGTG GAGGAGACAA TACCCTCATT CACGGGGAGG AGCCCAAACC 1140 ACTGACCCAC AGACTCTGCA CCCCGACGCC AGAGATACCT GGAGCGACGG CTGCTGAAAG 1200 AGGCTGTCCA CCTGGCGAAA CCACCGGAGC CCGGAGGCTT GGGGGCTCCG CCCTGGGCTG 1260 GCTTCCGTCT CCTCCAGTGG AGGGAGAGGT GGGGCCCCTG CTGGGGTAGA GCTGGGGACG 1320 CCACGTGCCA TTCCCATGGG CCAGTGAGGG CCTGGGGCCT CTGTTCTGCT GTGGCCTGAG 1380 CTCCCCAGAG TCCTGAGGAG GAGCGCCAGT TGCCCCTCGC TCACAGACCA CACACCCAGC 1440 CCTCCTGGGC CAGCCCAGAG GGCCCTTCAG ACCCCAGCTG TCTGCGCGTC TGACTCTTGT 1500 GGCCTCAGCA GGACAGGCCC CGGGCACTGC CTCACAGCCA AGGCTGGACT GGGTTGGCTG 1560 CAGTGTGGTG TTTAGTGGAT ACCACATCGG AAGTGATTTT CTAAATTGGA TTTGAATTCC 1620 GGTCCTGTCT TCTATTTGTC ATGAAACAGT GTATTTGGGG AGATGCTGTG GGAGGATGTA 1680 AATATCTTGT TTCTCCTCAA AAAAAAAAAA AAAAAAAAAA AAAA 1724 Seq ID NO : 118 DNA Sequence Nucleic Acid Accession 4 : Eos sequence Coding sequence : 42.. 1070 1 11 21 31 41 51 CAGGCACCAC CAGGACCAGC TGATCATTCC AGCCCACAGC AATGGAGCCA CATGACTCCT 60 CCCACATGGA CTCTGAGTTC CGATACACTC TCTTCCCGAT TGTTTACAGC ATCATCTTTG 120 TGCTCGGGGT CATTGCTAAT GGCTACGTGC TGTGGGTCTT TGCCCGCCTG TACCCTTGCA 180 AGAAATTCAA TGAGATAAAG ATCTTCATGG TGAACCTCAC CATGGCGGAC ATGCTCTTCT 240 TGATCACCCT GCCACTTTGG ATTGTCTACT ACCAAAACCA GGGCAACTGG ATACTCCCCA 300 AATTCCTGTG CAACGTGGCT GGCTGCCTTT TCTTCATCAA CACCTACTGC TCTGTGGCCT 360 TCCTGGGCGT CATCACTTAT AACCGCTTCC AGGCAGTAAC TCGGCCCATC AAGACTGCTC 420

AGGCCAACAC CCGCAAGCGT GGCATCTCTT TGTCCTTGGT CATCTGGGTG GCCATTGTGG 480 GAGCTGCATC CTACTTCCTC ATCCTGGACT CCACCAACAC AGTGCCCGAC AGTGCTGGCT 540 CAGGCAACGT CACTCGCTGC TTTGAGCATT ACGAGAAGGG CAGCGTGCCA GTCCTCATCA 600 TCCACATCTT CATCGTGTTC AGCTTCTTCC TGGTCTTCCT CATCATCCTC TTCTGCAACC 660 TGGTCATCAT CCGTACCTTG CTCATGCAGC CGGTGCAGCA GCAGCGCAAC GCTGAAGTCA 720 AGCGCCGGGC GCTGTGGATG GTGTGCACGG TCTTGGCGGT GTTCATCATC TGCTTCGTGC 780 CCCACCACGT GGTGCAGCTG CCCTGGACCC TTGCTGAGCT GGGCTTCCAG GACAGCAAAT 840 TCCACCAGGC CATTAATGAT GCACATCAGG TCACCCTCTG CCTCCTTAGC ACCAACTGTG 900 TCTTAGACCC TGTTATCTAC TGTTTCCTCA CCAAGAAGTT CCGCAAGCAC CTCACCGAAA 960 AGTTCTACAG CATGCGCAGT AGCCGGAAAT GCTCCCGGGC CACCACGGAT ACGGTCACTG 1020 AAGTGGTTGT GCCATTCAAC CAGATCCCTG GCAATTCCCT CAAAAATTAG TCCCTGCTTC 1080 CAGGCCTGAA GTCTTCTCCT CCATGAACAT CATGGACTGA GCTGGGGGAA GAAGGGATAT 1140 CTACTGTGGT CTGGGCACCA CCTCTGTGGG CACTGGTGGG CCATTAGATT TGGAGGCTAC 1200 CTCACCTGGG CAGGGATGAT GGCAGAGCCA GGCTGTTGGA AAATCCAGAA CTCAAATGAG 1260 CCCCTTCATC CGCCTGTGGG CGCATACTAC AGTAACTGTG ACTGATGACT TTATCCTGAG 1320 TCCCTTAATC TTATGGGGCC GGAAGGAATG TCAGGGCCAG GTGCAGACCT TGGGGGAAGA 1380 CTTTAAACCA CCTAGTTCTC CCCGATGGGG CATCGGTCTA AAGCTTTGGG GGAGTGGGCG 1440 CAGTGGCTCA CACCTGTAAT CCCAGCACTT TGGGAGGCCG AGGTGGGCAG ATCATGGGTC 1500 AAGAGATCGA GACCATCCTG GCCAACATTG TAAAACCCCA TCTCTACTAA AACATACAAA 1560 AATTAGCCGG GCATGGTGGC ACACGCCTGT AGTCCCAGCT ACTCAGGAGG CTGAGGCAGG 1620 AGAATCGCTT GAACCTGGGA GGCAGAGGTT GCAGTGAACC TAGATTGCAC CATTGCACTC 1680 TAGCCTGGCA ACAGAGCGAG ATTCCATCTC AAAAAAAAAA AAAAAAAAAA AAAAAAAGCT 1740 TTGGGCAACT ACTCTCAAGT GATAGAGGTA GACTGGGTTA GGAAAGGACA CTGCCCTCAC 1800 TGTATGGCAC TACCTTGGGG CAGACTTTTG AGCTAAGATG TTGCCATCCT CTCTCCACCC 1860 TCCGGCACAA GGTCTTTGTG ACCTTTCTCA GGGGAAGGGG CTTGATGGAA CCTTCTCTGA 1920 CTCATCTGGC AACCTGTCCC TAATGGTGAC CAAAGAAGAT AAAACATGAA CAGACCAAAA 1980 GCTAGGACAA GAGCTTGCTT CCCAAGACAG ACGTGTCTGT CTGCAAAGGC CTTGCCTCTA 2040 GTCCAGTCAG CTCTGGGGGA GTGGGAAGGA GATGCCCACC TCCTCTTTCT GTCTCAACAA 2100 TAGTCCCTAA TTAAGTACCT TCTGTGGGGC AGCCACCCAC TGAGGGTGGG CAAAGGCCCC 2160 TTGAAAGCAA AATTGGGGCT GGGCTCAGTG GCTCATGCCT ATAATCCCAG CACTTTGGGA 2220 GGCCAAGGCA GGCAGATCAC CTGAGGTCCG GAGTTCGAGA CCAGCCTGGC CAACGTGGTG 2280 AAACGCCATC TCCACTAAGA ATACAAAAAT ATGGCTCATG CCTGTAATCC CAGTACTTTG 2340 GGAGGCTGAG GTGGGCCGAT CATTTGAAGT TAGGAGTTTG AGACCAGCCT GACCAATATG 2400 GTAAAACCCC GTCTCTACTA AAAATACAAA AAAATTAGCC TGGCGTGGTG GCGCATGCCT 2460 GTAGTCCCAT AGGCTGTAGC TACTGGGAGG AGGCGGAGCT TGCAGTGAGC CGAGATCACG 2520 CCACTGCTCT CCAGCCTGGG CGACAGAGTG AGACTCTGTG TCAAAAACAA ACAAACAAAC 2580 AAAAAAGGCA AAATTGGAGC TGTCCAGGCC AGGACACCCC GATGTCCAGG GGCTTCCATA 2640 CGAACAGGCA CATGGGCTGG GAAGTACATG AGGCCCCTGG GTAGAAGGGT CTGTCAGTTC 2700 TCTCCTCCCT TGCCCTCTGG GAGGGTCCTC CTAACATAGC TTCCAGGAGG TGGGAGGAGC 2760 AGTTACTGTC AGCAGGTGTC AGCCAGGTGT CAGCTTCTCC TGGGGATCTC TAGATGTCTG 2820 CTTGTGATTT TTGGCAAGTA TATGCAAATG AGCCTCCTCT CCTGCCCTGA GACAAGTATC 2880 TGCAGTGTGA ACCTGGCAGC CTCAGACCCA AGGGGCTCAG AGGAAACTTC TCTGGTTTCT 2940 AGAGCTCTGT GCTCCTTCAG AGAAGTCTTC CTTCCTTCCA GTCAGTGTCC CTGTGAAGCT 3000 GGGATACTCA TTTCCTGTGT ACCGGGCAAA CACCGGATTG CTGATTTTGA GAAATGCCTC 3060 TCGATGGACC TGTAACCTGC TGGAGTCTGG GATGGTAGCT GTGGGCTGGA CTTGGCTGAT 3120 GGGATGACCC GGTGGCTAGT GCAGCATCAC ACAAGCCTGG TTCAAGTCTT GGCTGTGTCA 3180 TTTCCTGCTG AGGGACCAGG CACTGAATTT CCTACCTCTT AGGGTCATTA CCTATGAGGT 3240 TAAAGCTACC TCATGGGATT GTTATACGCC ACTAATGTTG AGGCAGACAC CTCTTGGCAG 3300 GGTGACTGCT CATCTTAGAC CCTCCCCTTT TCTGCGAATT TGGGCCCCTT GATCCTCTGA 3360 TGGGAGCTGA AAGGATGAGA GGTGGGCATC TAGATTTAGG GAGGCTGTTC AGGCTTTGCA 3420 GGTCCCTTAC CTGAACACAT AGAAACCCTG GAGCTGTGAC TGTGTCCATG TGTGTGTGTT 3480 TGTCTGTGTG TGTTGCGGGG GATGGGCACC TGCATGAATG TGGTAGAGAA AATGGCTCTG 3540 CTCAGAGGGA AGATACGCAT AGCAAGGCAG GGACCAGAGG AATCACAGGC GCCTGGAGAG 3600 CAGCCGGGCA CCGCCTCCAG GGACCTGCCG GCTTCCCTCA GTCCTCCAGG GGCCCAGCAC 3660 TCTTCCTTTA GGCCCTGTGA GCGTCCCTTG TCAGGATACA TTCTCTCATT TTGCTGAAGC 3720 TGATTTGATT GGGTGTCTGT TTCTCGCAGC CAAAAGAGCT CTGAATGAGG AAAGTGCTTC 3780 TGTGCTAACT CCCCGCGTCT CCTGAATTTC AGTCATTCAT GTACCCGCCT CGAAATTTTT 3840 GCAATATCTG TGTACCAACT GTCCATTTAC TTAATAAAGA AGTTTTCTTT AAATTAAGTC 3900 ACTTTTAA 3908 Seq ID NO : 119 DNA Sequence Nucleic Acid Accession # : NM 003271. 2 Coding sequence : 137.. 853 1 11 21 31 41 51 1 1 1 1 1 1 GCGGGAGGCG GCGGCGCAGA GCTTGGGGCT TCCTTGGTCG CACCCACCAC CTGCCTGCCC 60 ACTGGTCAGC CTTCAGGGAC CCTGAGCACC GCCTGGTCTC TTTCCTGTGG CCAGCCCAGA 120 ACTGAAGCGC TGCGGCATGG CGCGCGCCTG CCTCCAGGCC GTCAAGTACC TCATGTTCGC 180 CTTCAACCTG CTCTTCTGGC TGGGAGGCTG TGGCGTGCTG GGTGTCGGCA TCTGGCTGGC 240 CGCCACACAG GGGAGCTTCG CCACGCTGTC CTCTTCCTTC CCGTCCCTGT CGGCTGCCAA 300 CCTGCTCATC ATCACCGGCG CCTTTGTCAT GGCCATCGGC TTCGTGGGCT GCCTGGGTGC 360 CATCAAGGAG AACAAGTGCC TCCTGCTCAC TTTCTTCCTG CTGCTGCTGC TGGTGTTCCT 420 GCTGGAGGCC ACCATCGCCA TCCTCTTCTT CGCCTACACG GACAAGATTG ACAGGTATGC 480 CCAGCAAGAC CTGAAGAAAG GCTTGCACCT GTACGGCACG CAGGGCAACG TGGGCCTCAC 540 CAACGCCTGG AGCATCATCC AGACCGACTT CCGCTGCTGT GGCGTCTCCA ACTACACTGA 600 CTGGTTCGAG GTGTACAACG CCACGCGGGT ACCTGACTCC TGCTGCTTGG AGTTCAGTGA 660 GAGCTGTGGG CTGCACGCCC CCGGCACCTG GTGGAAGGCG CCGTGCTACG AGACGGTGAA 720 GGTGTGGCTT CAGGAGAACC TGCTGGCTGT GGGCATCTTT GGGCTGTGCA CGGCGCTGGT 780 GCAGATCCTG GGCCTGACCT TCGCCATGAC CATGTACTGC CAAGTGGTCA AGGCAGACAC 840 CTACTGCGCG TAGGCCGCCC ACCGCCCGCT TCTCTGCCAA AAGGACGCCC ACGGGGAGAT 900 GGCCGCACCC ACAGCTGCCT TTCCCACCAC CAGCCTCGGT GCTCTGCCCC ATGCTGGGAG 960 GAGGGAGGGA GGGACAGGTG CCTGGAGCCC CCGGAACCCT GTTTCTGGAA GGCCCTAGCT 1020 CAGGTGGCTT CAGGGCCTCC GGACCCCCCC TGGGAGGGGT GGCCACGTGC TGGCTGCGGA 1080 ACCCAGGGCA GGGGTGGGAG GGGCCTCCAG CACTTTTTAT ATTTACGTAT TCTCCAAAGC 1140

AGTGTTCACA CGGGAGCCAG CCTGTGGCCC CCAGCCTCCT GGAAAACAGG TTGGCGCTGG 1200 AGGAGCCGGG TCTTGGCATC CTGGAGGTGG CCCCACTGGT CCTGGTGCTC CAGGCGGGGC 1260 CGTGGACCCC TCACCTACAT TCCATAGTGG GCCCGTGGGG CTCCTGGTGC ATCTTAATAA 1320 AGTGTGAGCA GCAAAAAAAA AAAAAAAAAA AAA 1353 Seq ID NO : 120 DNA Sequence Nucleic Acid Accession # : Nom 005629. 1 Coding sequence : 639.. 2546 1 11 21 31 41 51 TAGTCGGAGC GAGGTGGCGA GTCGCTGAGC CCGCCGCGGC CCCGAGAGCG GCTGCAGCCG 60 CCGCCGCCGG GAAGGAGAGG GCGAGGCGCG CCCGAGCCGC CGCCGCCGCC GCCACCGCCG 120 CCGCCGCCAC CACCGCCACC GGAGTCGCGG GCCAGCCGGG CAGCCTCCGC GGGCCCCGGC 180 CGGGGCGGGG GGCGCGGGCC ACAGGCCCCT GCTCCGGCCG TCGTTTGCAG ACCGCGGGCG 240 CCGATGTCGC CCGCGCCCCG TTAGGATGAG TCTCGGGTCG GGCGAGGAGC CGCCGCAGCC 300 GCCGCCGCCC GAGCCGCGGG CAGGAGCCTC GGGAGCCGCC GCCGCCGCCG CCGCCGCCCG 360 GCCGGGCCCC GACGCCGCCC GCGCGCCCCC GGGCCCCCGA CACACATGAG ATTCTTCAGG 420 CTCACTTTCA AGTGCTTCGT GGACTGCTTC TGACTGCGCC GCCCGCGCCC CGCACCCCGC 480 CGTCCGCCCG CCGCCCCGTC CCCCGGCCCG GCCGCCCCCC GGCCCCCGGC CGGCCCGCGC 540 CCTCGGGGCC CTCCCCGGTG CCGCCGGTGC CCCCCGCCTG ACCGCCGCCC CCCGTGAGGC 600 GCCGCGACCC CGGCCCGGCC GTGCGGCCCG CCGGGGCCAT GGCGAAGAAG AGCGCCGAGA 660 ACGGCATCTA TAGCGTGTCC GGCGACGAGA AGAAGGGCCC CCTCATCGCG CCCGGGCCCG 720 ACGGGGCCCC GGCCAAGGGC GACGGCCCCG TGGGCCTGGG GACACCCGGC GGCCGCCTGG 780 CCGTGCCGCC GCGCGAGACC TGGACGCGCC AGATGGACTT CATCATGTCG TGCGTGGGCT 840 TCGCCGTGGG CTTGGGCAAC GTGTGGCGCT TCCCCTACCT GTGCTACAAG AACGGCGGAG 900 GTGTGTTCCT TATTCCCTAC GTCCTGATCG CCCTGGTTGG AGGAATCCCC ATTTTCTTCT 960 TAGAGATCTC GCTGGGCCAG TTCATGAAGG CCGGCAGCAT CAATGTCTGG AACATCTGTC 1020 CCCTGTTCAA AGGCCTGGGC TACGCCTCCA TGGTGATCGT CTTCTACTGC AACACCTACT 1080 ACATCATGGT GCTGGCCTGG GGCTTCTATT ACCTGGTCAA GTCCTTTACC ACCACGCTGC 1140 CCTGGGCCAC ATGTGGCCAC ACCTGGAACA CTCCCGACTG CGTGGAGATC TTCCGCCATG 1200 AAGACTGTGC CAATGCCAGC CTGGCCAACC TCACCTGTGA CCAGCTTGCT GACCGCCGGT 1260 CCCCTGTCAT CGAGTTCTGG GAGAACAAAG TCTTGAGGCT GTCTGGGGGA CTGGAGGTGC 1320 CAGGGGCCCT CAACTGGGAG GTGACCCTTT GTCTGCTGGC CTGCTGGGTG CTGGTCTACT 1380 TCTGTGTCTG GAAGGGGGTC AAATCCACGG GAAAGATCGT GTACTTCACT GCTACATTCC 1440 CCTACGTGGT CCTGGTCGTG CTGCTGGTGC GTGGAGTGCT GCTGCCTGGC GCC « GGATG lS00 GCATCATTTA CTATCTCAAG CCTGACTGGT CAAAGCTGGG GTCCCCTCAG GTGTGGATAG 1560 ATGCGGGGAC CCAGATTTTC TTTTCTTACG CCATTGGCCT GGGGGCCCTC ACAGCCCTGG 1620 GCAGCTACAA CCGCTTCAAC AACAACTGCT ACAAGGACGC CATCATCCTG GCTCTCATCA 1680 ACAGTGGGAC CAGCTTCTTT GCTGGCTTCG TGGTCTTCTC CATCCTGGGC TTCATGGCTG 1740 CAGAGCAGGG CGTGCACATC TCCAAGGTGG CAGAGTCAGG GCCGGGCCTG GCCTTCATCG 1800 CCTACCCGCG GGCTGTCACG CTGATGCCAG TGGCCCCACT CTGGGCTGCC CTGTTCTTCT 1860 TCATGCTGTT GCTGCTTGGT CTCGACAGCC AGTTTGTAGG TGTGGAGGGC TTCATCACCG 1920 GCCTCCTCGA CCTCCTCCCG GCCTCCTACT ACTTCCGTTT CCAAAGGGAG ATCTCTGTGG 1980 CCCTCTGTTG TGCCCTCTGC TTTGTCATCG ATCTCTCCAT GGTGACTGAT GGCGGGATGT 2040 ACGTCTTCCA GCTGTTTGAC TACTACTCGG CCAGCGGCAC CACCCTGCTC TGGCAGGCCT 2100 TTTGGGAGTG CGTGGTGGTG GCCTGGGTGT ACGGAGCTGA CCGCTTCATG GACGACATTG 2160 CCTGTATGAT CGGGTACCGA CCTTGCCCCT GGATGAAATG GTGCTGGTCC TTCTTCACCC 2220 CGCTGGTCTG CATGGGCATC TTCATCTTCA ACGTTGTGTA CTACGAGCCG CTGGTCTACA 2280 ACAACACCTA CGTGTACCCG TGGTGGGGTG AGGCCATGGG CTGGGCCTTC GCCCTGTCCT 2340 CCATGCTGTG CGTGCCGCTG CACCTCCTGG GCTGCCTCCT CAGGGCCAAG GGCACCATGG 2400 CTGAGCGCTG GCAGCACCTG ACCCAGCCCA TCTGGGGCCT CCACCACTTG GAGTACCGAG 2460 CTCAGGACGC AGATGTCAGG GGCCTGACCA CCCTGACCCC AGTGTCCGAG AGCAGCAAGG 2520 TCGTCGTGGT GGAGAGTGTC ATGTGACAAC TCAGCTCACA TCACCAGCTC ACCTCTGGTA 2580 GCCATAGCAG CCCCTGCTTC AGCCCCACCG CACCCCTCCA GGGGGCCTGC CTTTCCCTGA 2640 CACTTTTGGG GTCTGCCTGG GGGAGGAGGG GAGAAAGCAC CATGAGTGCT CACTAAAACA 2700 ACTTTTTCCA TTTTTAATAA AACGCCAAAA ATATCACAAC CCACCAAAAA TAGATGCCTC 2760 TCCCCCTCCA GCCCTAGCCG AGCTGGTCCT AGGCCCCGCC TAGTGCCCCA CCCCCACCCA 2820 CAGTGCTGCA CTCCTCCTGC CCCTGCCACG CCCACCCCCT GCCCACCTCT CCAGGCTCTG 2880 CTCTGCAGCA CACCCGTGGG TGACCCCTCA CCCCAGAAGC AGCAGTGGCA GCTTGGGAAA 2940 TGTGAGGAAG GGAAGGAGGG AGAGACGGGA GGGAGGAGAG AGAGGAGAAG GGAGGCAGGG 3000 GAGGGGCAGC AGAACCAAGG CAAATATTTC AGCTGGGCTA TACCCCTCTC CCCATCCCTG 3060 TTATAGAAGC TTAGAGAGCC AGCCAGCAAT GGAACCTTCT GGTTCCTGCG CCAATCGCCA 3120 CCAGTATCAA TTGTGTGAGC TTGGGTGCGA GTGCACGCGT GCGTGAGTAC GGAGAGTATA 3180 TATAGATCTC TATCTCTTAG CAAAGGTGAA TGCCAGATGT AAATGGCGCC TCTGGGCAAA 3240 GGAGGCTTGT ATTTTGCACA TTTTATAAAA ACTTGAGAGA ATGAGATTTC TGCTTGTATA 3300 TTTCTAAAAA GAGGAAGGAG CCCAAACCAT CCTCTCCTTA CCACTCCCAT CCCTGTGAGC 3360 CCTACCTTAC CCCTCTGCCC CTAGCCAAGG AGTGTGAATT TATAGATCTA ACTTTCATAG 3420 GCAAAACAAA AGCTTCGAGC TGTTGCGTGT GTGAGTCTGT TGTGTGGATG TGCGTGTGTG 3480 GTCCCCAGCC CCAGACTGGA TTGGAAAAGT GCATGGTGGG GGCCTCGGGG CTGTCCCCAC 3540 GCTGTCCCTT TGCCACAAGT CTGTGGGGCA AGAGGCTGCA ATATTCCGTC CTGGGTGTCT 3600 GGGCTGCTAA CCTGGCCTGC TCAGGCTTCC CACCCTGTGC GGGGCACACC CCCAGGAAGG 3660 GACCCTGGAC ACGGCTCCCA CGTCCAGGCT TAAGGTGGAT GCACTTCCCG CACCTCCAGT 3720 CTTCTGTGTA GCAGCTTTAA CCCACGTTTG TCTGTCACGT CCAGTCCCGA GACGGCTGAG 3780 TGACCCCAAG AAAGGCTTCC CCGACACCCA GACAGAGGCT GCAGGGCTGG GGCTGGGTGA 3840 GGGTGGCGGG CCTGCGGGGA CATTCTACTG TGCTAAAAAG CCACTGCAGA CATAGCAATA 3900 AAAACATGTC ATTTTCC 3917 Seq ID NO : 121 DNA Sequence Nucleic Acid Accession # : Nom 013332. 1 Coding sequence : 206.. 397 1 11 21 31 41 51 ( GCACGAGGGC GCTTTTGTCT CCGGTGAGTT TTGTGGCGGG AAGCTTCTGC GCTGGTGCTT 60 AGTAACCGAC TTTCCTCCGG ACTCCTGCAC GACCTGCTCC TACAGCCGGC GATCCACTCC 120

CGGCTGTTCC CCCGGAGGGT CCAGAGGCCT TTCAGAAGGA GAAGGCAGCT CTGTTTCTCT 180 GCAGAGGAGT AGGGTCCTTT CAGCCATGAA GCATGTGTTG AACCTCTACC TGTTAGGTGT 240 GGTACTGACC CTACTCTCCA TCTTCGTTAG AGTGATGGAG TCCCTAGAAG GCTTACTAGA 300 GAGCCCATCG CCTGGGACCT CCTGGACCAC CAGAAGCCAA CTAGCCAACA CAGAGCCCAC 360 CAAGGGCCTT CCAGACCATC CATCCAGAAG CATGTGATAA GACCTCCTTC CATACTGGCC 420 ATATTTTGGA ACACTGACCT AGACATGTCC AGATGGGAGT CCCATTCCTA GCAGACAAGC 480 TGAGCACCGT TGTAACCAGA GAACTATTAC TAGGCCTTGA AGAACCTGTC TAACTGGATG 540 CTCATTGCCT GGGCAAGGCC TGTTTAGGCC GGTTGCGGTG GCTCATGCCT GTAATCCTAG 600 CACTTTGGGA GGCTGAGGTG GGTGGATCAC CTGAGGTCAG GAGTTCGAGA CCAGCCTCGC 660 CAACATGGCG AAACCCCATC TCTACTAAAA ATACAAAAGT TAGCTGGGTG TGGTGGCAGA 720 GGCCTGTAAT CCCAGTTCCT TGGGAGGCTG AGGCGGGAGA ATTGCTTGAA CCCGGGGACG 780 GAGGTTGCAG TGAACCGAGA TCGCACTGCT GTACCCAGCC TGGGCCACAG TGCAAGACTC 840 CATCTCAAAA AAAAAAAGAA AAGAAAAAGC CTGTTTAATG CACAGGTGTG AGTGGATTGC 900 TTATGGCTAT GAGATAGGTT GATCTCGCCC TTACCCCGGG GTCTGGTGTA TGCTGTGCTT 960 TCCTCAGCAG TATGGCTCTG ACATCTCTTA GATGTCCCAA CTTCAGCTGT TGGGAGATGG 1020 TGATATTTTC AACCCTACTT CCTAAACATC TGTCTGGGGT TCCTTTAGTC TTGAATGTCT 1080 TATGCTCAAT TATTTGGTGT TGAGCCTCTC TTCCACAAGA GCTCCTCCAT GTTTGGATAG 1140 CAGTTGAAGA GGTTGTGTGG GTGGGCTGTT GGGAGTGAGG ATGGAGTGTT CAGTGCCCAT 1200 TTCTCATTTT ACATTTTAAA GTCGTTCCTC CAACATAGTG TGTATTGGTC TGAAGGGGGT 1260 GGTGGGATGC CAAAGCCTGC TCAAGTTATG GACATTGTGG CCACCATGTG GCTTAAATGA 1320 TTTTTTCTAA CTAATAAAGT GGAATATATA TTTCAAAAAA AAAAAAAAAA AA 1372 Seq ID NO : 122 DNA Sequence Nucleic Acid Accession # : NM 020142. 2 Coding sequence : 274.. 537 1 11 21 31 41 51 GGCACGAGGG TCTCCGCCTG CAGGTGCAGA CATCTGGAGG AGAGAGTCGG AGAGCAGAAA 60 CCACTTGGCT CCCAGACAAT TCCCCTACAG GCTTTGGGCC TGGAATTGAG GAGAAAGTGA 120 GCTAAGTTGG GGTGGGGTGA GTCCAAAGAA GCACGGGCTG GGCCAAGCTA AGCTGCTCTG 180 GGCTGGGCTG ATCCCTCCCC ACTCAGGGGC GGGACCCCAG GAGGAGGGAG AGGACAGAGC 240 CACTGCAGAG GACCAGACTG GGAAAACAAC GATATGGCAG GAGCCAGTCT TGGGGCCCGC 300 TTCTACCGGC AGATCAAAAG ACATCCGGGG ATCATCCCGA TGATCGGCTT AATCTGCCTG 360 GGCATGGGCA GCGCTGCGCT TTACTTGCTG CGACTCGCCC TTCGCAGCCC CGACGTCTGC 420 TGGGACAGAA AGAACAACCC GGAGCCCTGG AACCGCCTGA GCCCCAATGA CCAATACAAG 480 TTCCTTGCAG TTTCCACTGA CTATAAGAAG CTGAAGAAGG ACCGGCCAGA CTTCTAAGCC 540 AGGCTGGGCT GCCAGTGCCA TGCAAGCCAC AGCCAGCCAG CCCATCCACT TCTTCCACTC 600 CTCCCCGCAG GCCCCAAGGC ATCACTCCGG CCACCCTGTC CCGCTACTGC TTACACAGGC 660 CGGGTTCCCA CGCAGAGGGG AGGCTGCTCC ACCCCTACTC TCCTCCCTTG CTCCCAGCAG 720 CGGAAGCGCC TCTGACCCTT GGCTTGAGTC CCACGTGGGG GAGGAGGAGG CAGGCAGCAC 780 CAGCAGGGGT CCACCAAGAG CCCAGACCAG CCCCTCTGCC CTCCTACCCG GGCCTCGAAG 840 GGTGTGGCAC AGGCTACGTG TTGAGCGTGG CCTACGTGAG CCAACAAGAA GCAGGGGCCT 900 CTGAGTGCCA AGCGACGTGG CGGGCTCCAC GTTAGCCCAG GCTCTGAGAG CCAGCCCAGG 960 GGCGGCGCTG CTCAGCTTGG GCTGGTCCAG GGCCTGCCCA GGCTGGGGCA CCTTTGCCTC 1020 CTGAGGCGCA GCGCACTCCT CCCCTGCCCA AGCCTACTGC CTCCCGCTGC CGCCAGTACC 1080 CCCTCCAGCC CCACACCTGG GCCTCCCCCT GCCACTCCCC TCCCTTGCTC CCCTCTGTCC 1140 CCAGGGATCA AACAGAAGCA GCCGTGGGCA AAATACAATT TCATTTAACA AATTGAAAAA 1200 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 1260 AAAAAAAAAA AAAAAAAAAA AAAA 1284 Seq ID NO : 123 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TCTTGACTGA AATTCTCTCC TGATGCTGAG CCCTGCACCC CACCTTCCTT TTCCTAACTA 60 TGAATTGATG GCAAAGTCCA CTCAAAACAA CCAGTTAAGT GCTCACGAGA GAGTAGTCAA 120 GCACCTCCAG AAAGAAACCG GGTTTTTGTT CACATAGCAG GAAGTGACTC CCTGGGTGGT 180 AATTTATCTT GGAAACACAG GTAGATTGGC AGAAAAACGG GAACATGTAG GTACCGCGAT 240 GTTGGTGCAT GTCCATTACT TTGGGATAGG CTTTCTCAGT CTTTCCTCAA ATGATAGTTG 300 AGCCAGTTTT CCAGTGGCAA TTCTGAGTGA CTTGCGCTTG TCTTATGGTG TGGTCAAGGG 360 ACGTTCAGAA CTACGGAAAA CTTTTACTGA AACAGCGAAG CAGAGTATAC CGGCATGAGA 420 GGGAAGATGA ACACTCACCT ATGTACCACT CTTTGACAAT AAATATAGTA TTTCTCAAAT 480 CAGTCTCAAG ACTGATCCTG TCTCAGAACA GACCATTGTT CTCTCATTTC TCTAATACGC 540 TGAGAGGAAC ACTCTGAATA AAGGCTAAGT GGTGGAGCAT GCAA 584 Seq ID NO : 124 DNA Sequence Nucleic Acid Accession # : NM 002204. 1 Coding sequence : 74.. 3229 1 11 21 31 41 51 ( AGGTGAACAG GTCCTCACGC CCAGCTCCGC CCCCTCACGC GCTCTCGCCG GGACCCCGCT 60 TCCGCTGGCA GCCATGGGCC CCGGCCCCAG CCGCGCGCCC CGCGCCCCAC GCCTGATGCT 120 CTGTGCGCTC GCCTTGATGG TGGCGGCCGG CGGCTGCGTC GTCTCCGCCT TCAACCTGGA 180 TACCCGATTC CTGGTAGTGA AGGAGGCCGG GAACCCGGGC AGCCTCTTCG GCTACTCGGT 240 CGCCCTCCAT CGGCAGACAG AGCGGCAGCA GCGCTACCTG CTCCTGGCTG GTGCCCCCCG 300 GGAGCTCGCT GTGCCCGATG GCTACACCAA CCGGACTGGT GCTGTGTACC TGTGCCCACT 360 CACTGCCCAC AAGGATGACT GTGAGCGGAT GAACATCACA GTGAAAAATG ACCCTGGCCA 420 TCACATTATT GAGGACATGT GGCTTGGAGT GACTGTGGCC AGCCAGGGCC CTGCAGGCAG 480 AGTTCTGGTC TGTGCCCACC GCTACACCCA GGTGCTGTGG TCAGGGTCAG AAGACCAGCG 540 GCGCATGGTG GGCAAGTGCT ACGTGCGAGG CAATGACCTA GAGCTGGACT CCAGTGATGA 600 CTGGCAGACC TACCACAACG AGATGTGCAA TAGCAACACA GACTACCTGG AGACGGGCAT 660 GTGCCAGCTG GGCACCAGCG GTGGCTTCAC CCAGAACACT GTGTACTTCG GCGCCCCCGG 720 TGCCTACAAC TGGAAAGGAA ACAGCTACAT GATTCAGCGC AAGGAGTGGG ACTTATCTGA 780 GTATAGTTAC AAGGACCCAG AGGACCAAGG AAACCTCTAT ATTGGGTACA CGATGCAGGT 840

AGGCAGCTTC ATCCTGCACC CCAAAAACAT CACCATTGTG ACAGGTGCCC CACGGCACCG 900 ACATATGGGC GCGGTGTTCT TGCTGAGCCA GGAGGCAGGC GGAGACCTGC GGAGGAGGCA 960 GGTGCTGGAG GGCTCGCAGG TGGGCGCCTA TTTTGGCAGC GCAATTGCCC TGGCAGACCT 1020 GAACAATGAT GGGTGGCAGG ACCTCCTGGT GGGCGCCCCC TACTACTTCG AGAGGAAAGA 1080 GGAAGTAGGG GGTGCCATCT ATGTCTTCAT GAACCAGGCG GGAACCTCCT TCCCTGCTCA 1140 CCCCTCACTC CTTCTTCATG GCCCCAGTGG CTCTGCCTTT GGTTTATCTG TGGCCAGCAT 1200 TGGTGACATC AACCAGGATG GATTTCAGGA TATTGCTGTG GGAGCTCCGT TTGAAGGCTT 1260 GGGCAAAGTG TACATCTATC ACAGTAGCTC TAAGGGGCTC CTTAGACAGC CCCAGCAGGT 1320 AATCCATGGA GAGAAGCTGG GACTGCCTGG GTTGGCCACC TTCGGCTATT CCCTCAGTGG 1380 GCAGATGGAT GTGGATGAGA ACTTCTACCC AGACCTTCTA GTGGGAAGCC TGTCAGACCA 1440 CATTGTGCTG CTGCGGGCCC GGCCAGTCAT CAACATCGTC CACAAGACCT TGGTGCCCAG 1500 GCCAGCTGTG CTGGACCCTG CACTTTGCAC GGCCACCTCT TGTGTGCAAG TGGAGCTGTG 1560 CTTTGCTTAC AACCAGAGTG CCGGGAACCC CAACTACAGG CGAAACATCA CCCTGGCCTA 1620 CACTCTGGAG GCTGACAGGG ACCGCCGGCC GCCCCGGCTC CGCTTTGCCG GCAGTGAGTC 1680 CGCTGTCTTC CACGGCTTCT TCTCCATGCC CGAGATGCGC TGCCAGAAGC TGGAGCTGCT 1740 CCTGATGGAC AACCTCCGTG ACAAACTCCG CCCCATCATC ATCTCCATGA ACTACTCTTT 1800 ACCTTTGCGG ATGCCCGATC GCCCCCGGCT GGGGCTGCGG TCCCTGGACG CCTACCCGAT 1860 CCTCAACCAG GCACAGGCTC TGGAGAACCA CACTGAGGTC CAGTTCCAGA AGGAGTGCGG 1920 GCCTGACAAC AAGTGTGAGA GCAACTTGCA GATGCGGGCA GCCTTCGTGT CAGAGCAGCA 1980 GCAGAAGCTG AGCAGGCTCC AGTACAGCAG AGACGTCCGG AAATTGCTCC TGAGCATCAA 2040 CGTGACGAAC ACCCGGACCT CGGAGCGCTC CGGGGAGGAC GCCCACGAGG CGCTGCTCAC 2100 CCTGGTGGTG CCTCCCGCCC TGCTGCTGTC CTCAGTGCGC CCCCCCGGGG CCTGCCAAGC 2160 TAATGAGACC ATCTTTTGCG AGCTGGGGAA CCCCTTCAAA CGGAACCAGA GGATGGAGCT 2220 GCTCATCGCC TTTGAGGTCA TCGGGGTGAC CCTGCACACA AGGGACCTTC AGGTGCAGCT 2280 GCAGCTCTCC ACGTCGAGTC ACCAGGACAA CCTGTGGCCC ATGATCCTCA CTCTGCTGGT 2340 GGACTATACA CTCCAGACCT CGCTTAGCAT GGTAAATCAC CGGCTACAAA GCTTCTTTGG 2400 GGGGACAGTG ATGGGTGAGT CTGGCATGAA AACTGTGGAG GATGTAGGAA GCCCCCTCAA 2460 GTATGAATTC CAGGTGGGCC CAATGGGGGA GGGGCTGGTG GGCCTGGGGA CCCTGGTCCT 2520 AGGTCTGGAG TGGCCCTACG AAGTCAGCAA TGGCAAGTGG CTGCTGTATC CCACGGAGAT 2580 CACCGTCCAT GGCAATGGGT CCTGGCCCTG CCGACCACCT GGAGACCTTA TCAACCCTCT 2640 CAACCTCACT CTTTCTGACC CTGGGGACAG GCCATCATCC CCACAGCGCA GGCGCCGACA 2700 GCTGGATCCA GGGGGAGGCC AGGGCCCCCC ACCTGTCACT CTGGCTGCTG CCAAAAAAGC 2760 CAAGTCTGAG ACTGTGCTGA CCTGTGCCAC AGGGCGTGCC CACTGTGTGT GGCTAGAGTG 2820 CCCCATCCCT GATGCCCCCG TTGTCACCAA CGTGACTGTG AAGGCACGAG TGTGGAACAG 2880 CACCTTCATC GAGGATTACA GAGACTTTGA CCGAGTCCGG GTAAATGGCT GGGCTACCCT 2940 ATTCCTCCGA ACCAGCATCC CCACCATCAA CATGGAGAAC AAGACCACGT GGTTCTCTGT 3000 GGACATTGAC TCGGAGCTGG TGGAGGAGCT GCCGGCCGAA ATCGAGCTGT GGCTGGTGCT 3060 GGTGGCCGTG GGTGCAGGGC TGCTGCTGCT GGGGCTGATC ATCCTCCTGC TGTGGAAGTG 3120 CGGCTTCTTC AAGCGAGCCC GCACTCGCGC CCTGTATGAA GCTAAGAGGC AGAAGGCGGA 3180 GATGAAGAGC CAGCCGTCAG AGACAGAGAG GCTGACCGAC GACTACTGAG GGGGCAGCCC 3240 CCCGCCCCCG GCCCACCTGG TGTGACTTCT TTAAGCGGAC CCGCTATTAT CAGATCATGC 3300 CCAAGTACCA CGCAGTGCGG ATCCGGGAGG AGGAGCGCTA CCCACCTCCA GGGAGCACCC 3360 TGCCCACCAA GAAGCACTGG GTGACCAGCT GGCAGACTCG GGACCAATAC TACTGACGTC 3420 CTCCCTGATC CCACCCCCTC CTCCCCCAGT GTCCCCTTTC TTCCTATTTA TCATAAGTTA 3480 TGCCTCTGAC AGTCCACAGG GGCCACCACC TTTGGCTGGT AGCAGCAGGC TCAGGCACAT 3540 ACACCTCGTC AAGAGCATGC ACATGCTGTC TGGCCCTGGG GATCTTCCCA CAGGAGGGCC 3600 AGCGCTGTGG ACCTTACAAC GCCGAGTGCA CTGCATTCCT GTGCCCTAGA TGCACGTGGG 3660 GCCCACTGCT CGTGGACTGT GCTGGTGCAT CACGGATGGT GCATGGGCTC GCCGTGTCTC 3720 AGCCTCTGCC AGCGCCAGCG CCAAAACAAG CCAAAGAGCC TCCCACCAGA GCCGGGAGGA 3780 AAAGGCCCCT GCAATGTGGT GACACCTCCC CTTTCACACC TGGATCCATC TTGAGAGCCA 3840 CAGTCACTGG ATTGACTTTG CTGTCAAAAC TACTGACAGG GAGCAGCCCC CGGGCCGCTG 3900 GCTGGTGGGC CCCCAATTGA CACCCATGCC AGAGAGGTGG GGATCCTGCC TAAGGTTGTC 3960 TACGGGGGCA CTTGGAGGAC CTGGCGTGCT CAGACCCAAC AGCAAAGGAA CTAGAAAGAA 4020 GGACCCAGAA GGCTTGCTTT CCTGCATCTC TGTGAAGCCT CTCTCCTTGG CCACAGACTG 4080 AACTCGCAGG GAGTGCAGCA GGAAGGAACA AAGACAGGCA AACGGCAACG TAGCCTGGGC 4140 TCACTGTGCT GGGGCATGGC GGGATCCTCC ACAGAGAGGA GGGGACCAAT TCTGGACAGA 4200 CAGATGTTGG GAGGATACAG AGGAGATGCC ACTTCTCACT CACCACTACC AGCCAGCCTC 4260 CAGAAGGCCC CAGAGAGACC CTGCAAGACC ACGGAGGGAG CCGACACTTG AATGTAGTAA 4320 TAGGCAGGGG GCCCTGCCAC CCCATCCAGC CAGACCCCAG CTGAACCATG CGTCAGGGGC 4380 CTAGAGGTGG AGTTCTTAGC TATCCTTGGC TTTCTGTGCC AGCCTGGCTC TGCCCCTCCC 4440 CCATGGGCTG TGTCCTAAGG CCCATTTGAG AAGCTGAGGC TAGTTCCAAA AACCTCTCCT 4500 GACCCCTGCC TGTTGGCAGC CCACTCCCCA GCCCCAGCCC CTTCCATGGT ACTGTAGCAG 4560 GGGAATTCCC TCCCCCTCCT TGTGCCTTCT TTGTATATAG GCTTCTCACC GCGACCAATA 4620 AACAGCTCCC AGTTTGT 4637 Seq ID NO : 125 DNA Sequence Nucleic Acid Accession # : NM005S01. 1 Coding sequence : 74.. 3274 1 11 21 31 41 51 AGGTGAACAG GTCCTCACGC CCAGCTCCGC CCCCTCACGC GCTCTCGCCG GGACCCCGCT 60 TCCGCTGGCA GCCATGGGCC CCGGCCCCAG CCGCGCGCCC CGCGCCCCAC GCCTGATGCT 120 CTGTGCGCTC GCCTTGATGG TGGCGGCCGG CGGCTGCGTC GTCTCCGCCT TCAACCTGGA 180 TACCCGATTC CTGGTAGTGA AGGAGGCCGG GAACCCGGGC AGCCTCTTCG GCTACTCGGT 240 CGCCCTCCAT CGGCAGACAG AGCGGCAGCA GCGCTACCTG CTCCTGGCTG GTGCCCCCCG 300 GGAGCTCGCT GTGCCCGATG GCTACACCAA CCGGACTGGT GCTGTGTACC TGTGCCCACT 360 CACTGCCCAC AAGGATGACT GTGAGCGGAT GAACATCACA GTGAAAAATG ACCCTGGCCA 420 TCACATTATT GAGGACATGT GGCTTGGAGT GACTGTGGCC AGCCAGGGCC CTGCAGGCAG 480 AGTTCTGGTC TGTGCCCACC GCTACACCCA GGTGCTGTGG TCAGGGTCAG AAGACCAGCG 540 GCGCATGGTG GGCAAGTGCT ACGTGCGAGG CAATGACCTA GAGCTGGACT CCAGTGATGA 600 CTGGCAGACC TACCACAACG AGATGTGCAA TAGCAACACA GACTACCTGG AGACGGGCAT 660 GTGCCAGCTG GGCACCAGCG GTGGCTTCAC CCAGAACACT GTGTACTTCG GCGCCCCCGG 720 TGCCTACAAC TGGAAAGGAA ACAGCTACAT GATTCAGCGC AAGGAGTGGG ACTTATCTGA 780 GTATAGTTAC AAGGACCCAG AGGACCAAGG AAACCTCTAT ATTGGGTACA CGATGCAGGT 840

AGGCAGCTTC ATCCTGCACC CCAAAAACAT CACCATTGTG ACAGGTGCCC CACGGCACCG 900 ACATATGGGC GCGGTGTTCT TGCTGAGCCA GGAGGCAGGC GGAGACCTGC GGAGGAGGCA 960 GGTGCTGGAG GGCTCGCAGG TGGGCGCCTA TTTTGGCAGC GCAATTGCCC TGGCAGACCT 1020 GAACAATGAT GGGTGGCAGG ACCTCCTGGT GGGCGCCCCC TACTACTTCG AGAGGAAAGA 1080 GGAAGTAGGG GGTGCCATCT ATGTCTTCAT GAACCAGGCG GGAACCTCCT TCCCTGCTCA 1140 CCCCTCACTC CTTCTTCATG GCCCCAGTGG CTCTGCCTTT GGTTTATCTG TGGCCAGCAT 1200 TGGTGACATC AACCAGGATG GATTTCAGGA TATTGCTGTG GGAGCTCCGT TTGAAGGCTT 1260 GGGCAAAGTG TACATCTATC ACAGTAGCTC TAAGGGGCTC CTTAGACAGC CCCAGCAGGT 1320 AATCCATGGA GAGAAGCTGG GACTGCCTGG GTTGGCCACC TTCGGCTATT CCCTCAGTGG 1380 GCAGATGGAT GTGGATGAGA ACTTCTACCC AGACCTTCTA GTGGGAAGCC TGTCAGACCA 1440 CATTGTGCTG CTGCGGGCCC GGCCAGTCAT CAACATCGTC CACAAGACCT TGGTGCCCAG 1500 GCCAGCTGTG CTGGACCCTG CACTTTGCAC GGCCACCTCT TGTGTGCAAG TGGAGCTGTG 1560 CTTTGCTTAC AACCAGAGTG CCGGGAACCC CAACTACAGG CGAAACATCA CCCTGGCCTA 1620 CACTCTGGAG GCTGACAGGG ACCGCCGGCC GCCCCGGCTC CGCTTTGCCG GCAGTGAGTC 1680 CGCTGTCTTC CACGGCTTCT TCTCCATGCC CGAGATGCGC TGCCAGAAGC TGGAGCTGCT 1740 CCTGATGGAC AACCTCCGTG ACAAACTCCG CCCCATCATC ATCTCCATGA ACTACTCTTT 1800 ACCTTTGCGG ATGCCCGATC GCCCCCGGCT GGGGCTGCGG TCCCTGGACG CCTACCCGAT 1860 CCTCAACCAG GCACAGGCTC TGGAGAACCA CACTGAGGTC CAGTTCCAGA AGGAGTGCGG 1920 GCCTGACAAC AAGTGTGAGA GCAACTTGCA GATGCGGGCA GCCTTCGTGT CAGAGCAGCA 1980 GCAGAAGCTG AGCAGGCTCC AGTACAGCAG AGACGTCCGG AAATTGCTCC TGAGCATCAA 2040 CGTGACGAAC ACCCGGACCT CGGAGCGCTC CGGGGAGGAC GCCCACGAGG CGCTGCTCAC 2100 CCTGGTGGTG CCTCCCGCCC TGCTGCTGTC CTCAGTGCGC CCCCCCGGGG CCTGCCAAGC 2160 TAATGAGACC ATCTTTTGCG AGCTGGGGAA CCCCTTCAAA CGGAACCAGA GGATGGAGCT 2220 GCTCATCGCC TTTGAGGTCA TCGGGGTGAC CCTGCACACA AGGGACCTTC AGGTGCAGCT 2280 GCAGCTCTCC ACGTCGAGTC ACCAGGACAA CCTGTGGCCC ATGATCCTCA CTCTGCTGGT 2340 GGACTATACA CTCCAGACCT CGCTTAGCAT GGTAAATCAC CGGCTACAAA GCTTCTTTGG 2400 GGGGACAGTG ATGGGTGAGT CTGGCATGAA AACTGTGGAG GATGTAGGAA GCCCCCTCAA 2460 GTATGAATTC CAGGTGGGCC CAATGGGGGA GGGGCTGGTG GGCCTGGGGA CCCTGGTCCT 2520 AGGTCTGGAG TGGCCCTACG AAGTCAGCAA TGGCAAGTGG CTGCTGTATC CCACGGAGAT 2580 CACCGTCCAT GGCAATGGGT CCTGGCCCTG CCGACCACCT GGAGACCTTA TCAACCCTCT 2640 CAACCTCACT CTTTCTGACC CTGGGGACAG GCCATCATCC CCACAGCGCA GGCGCCGACA 2700 GCTGGATCCA GGGGGAGGCC AGGGCCCCCC ACCTGTCACT CTGGCTGCTG CCAAAAAAGC 2760 CAAGTCTGAG ACTGTGCTGA CCTGTGCCAC AGGGCGTGCC CACTGTGTGT GGCTAGAGTG 2820 CCCCATCCCT GATGCCCCCG TTGTCACCAA CGTGACTGTG AAGGCACGAG TGTGGAACAG 2880 CACCTTCATC GAGGATTACA GAGACTTTGA CCGAGTCCGG GTAAATGGCT GGGCTACCCT 2940 ATTCCTCCGA ACCAGCATCC CCACCATCAA CATGGAGAAC AAGACCACGT GGTTCTCTGT 3000 GGACATTGAC TCGGAGCTGG TGGAGGAGCT GCCGGCCGAA ATCGAGCTGT GGCTGGTGCT 3060 GGTGGCCGTG GGTGCAGGGC TGCTGCTGCT GGGGCTGATC ATCCTCCTGC TGTGGAAGTG 3120 TGACTTCTTT AAGCGGACCC GCTATTATCA GATCATGCCC AAGTACCACG CAGTGCGGAT 3180 CCGGGAGGAG GAGCGCTACC CACCTCCAGG GAGCACCCTG CCCACCAAGA AGCACTGGGT 3240 GACCAGCTGG CAGACTCGGG ACCAATACTA CTGACGTCCT CCCTGATCCC ACCCCCTCCT 3300 CCCCCAGTGT CCCCTTTCTT CCTATTTATC ATAAGTTATG CCTCTGACAG TCCACAGGGG 3360 CCACCACCTT TGGCTGGTAG CAGCAGGCTC AGGCACATAC ACCTCGTCAA GAGCATGCAC 3420 ATGCTGTCTG GCCCTGGGGA TCTTCCCACA GGAGGGCCAG CGCTGTGGAC CTTACAACGC 3480 CGAGTGCACT GCATTCCTGT GCCCTAGATG CACGTGGGGC CCACTGCTCG TGGACTGTGC 3540 TGGTGCATCA CGGATGGTGC ATGGGCTCGC CGTGTCTCAG CCTCTGCCAG CGCCAGCGCC 3600 AAAACAAGCC AAAGAGCCTC CCACCAGAGC CGGGAGGAAA AGGCCCCTGC AATGTGGTGA 3660 CACCTCCCCT TTCACACCTG GATCCATCTT GAGAGCCACA GTCACTGGAT TGACTTTGCT 3720 GTCAAAACTA CTGACAGGGA GCAGCCCCCG GGCCGCTGGC TGGTGGGCCC CCAATTGACA 3780 CCCATGCCAG AGAGGTGGGG ATCCTGCCTA AGGTTGTCTA CGGGGGCACT TGGAGGACCT 3840 GGCGTGCTCA GACCCAACAG CAAAGGAACT AGAAAGAAGG ACCCAGAAGG CTTGCTTTCC 3900 TGCATCTCTG TGAAGCCTCT CTCCTTGGCC ACAGACTGAA CTCGCAGGGA GTGCAGCAGG 3960 AAGGAACAAA GACAGGCAAA CGGCAACGTA GCCTGGGCTC ACTGTGCTGG GGCATGGCGG 4020 GATCCTCCAC AGAGAGGAGG GGACCAATTC TGGACAGACA GATGTTGGGA GGATACAGAG 4080 GAGATGCCAC TTCTCACTCA CCACTACCAG CCAGCCTCCA GAAGGCCCCA GAGAGACCCT 4140 GCAAGACCAC GGAGGGAGCC GACACTTGAA TGTAGTAATA GGCAGGGGGC CCTGCCACCC 4200 CATCCAGCCA GACCCCAGCT GAACCATGCG TCAGGGGCCT AGAGGTGGAG TTCTTAGCTA 4260 TCCTTGGCTT TCTGTGCCAG CCTGGCTCTG CCCCTCCCCC ATGGGCTGTG TCCTAAGGCC 4320 CATTTGAGAA GCTGAGGCTA GTTCCAAAAA CCTCTCCTGA CCCCTGCCTG TTGGCAGCCC 4380 ACTCCCCAGC CCCAGCCCCT TCCATGGTAC TGTAGCAGGG GAATTCCCTC CCCCTCCTTG 4440 TGCCTTCTTT GTATATAGGC TTCTCACCGC GACCAATAAA CAGCTCCCAG TTTGT 4495 Seq ID NO : 126 DNA Sequence Nucleic Acid Accession # : NM003786 Coding sequence : 71.. 4654 1 11 21 31 41 51 1 1 1 1 1 1 CTCCGGCGCC CGCTCTGCCC GCCGCTGGGT CCGACCGCGC TCGCCTTCCT TGCAGCCGCG 60 CCTCGGCCCC ATGGACGCCC TGTGCGGTTC CGGGGAGCTC GGCTCCAAGT TCTGGGACTC 120 CAACCTGTCT GTGCACACAG AAAACCCGGA CCTCACTCCC TGCTTCCAGA ACTCCCTGCT 180 GGCCTGGGTG CCCTGCATCT ACCTGTGGGT CGCCCTGCCC TGCTACTTGC TCTACCTGCG 240 GCACCATTGT CGTGGCTACA TCATCCTCTC CCACCTGTCC AAGCTCAAGA TGGTCCTGGG 300 TGTCCTGCTG TGGTGCGTCT CCTGGGCGGA CCTTTTTTAC TCCTTCCATG GCCTGGTCCA 360 TGGCCGGGCC CCTGCCCCTG TTTTCTTTGT CACCCCCTTG GTGGTGGGGG TCACCATGCT 420 GCTGGCCACC CTGCTGATAC AGTATGAGCG GCTGCAGGGC GTACAGTCTT CGGGGGTCCT 480 CATTATCTTC TGGTTCCTGT GTGTGGTCTG CGCCATCGTC CCATTCCGCT CCAAGATCCT 540 TTTAGCCAAG GCAGAGGGTG AGATCTCAGA CCCCTTCCGC TTCACCACCT TCTACATCCA 600 CTTTGCCCTG GTACTCTCTG CCCTCATCTT GGCCTGCTTC AGGGAGAAAC CTCCATTTTT 660 CTCCGCAAAG AATGTCGACC CTAACCCCTA CCCTGAGACC AGCGCTGGCT TTCTCTCCCG 720 CCTGTTTTTC TGGTGGTTCA CAAAGATGGC CATCTATGGC TACCGGCATC CCCTGGAGGA 780 GAAGGACCTC TGGTCCCTAA AGGAAGAGGA CAGATCCCAG ATGGTGGTGC AGCAGCTGCT 840 GGAGGCATGG AGGAAGCAGG AAAAGCAGAC GGCACGACAC AAGGCTTCAG CAGCACCTGG 900 GAAAAATGCC TCCGGCGAGG ACGAGGTGCT GCTGGGTGCC CGGCCCAGGC CCCGGAAGCC 960 CTCCTTCCTG AAGGCCCTGC TGGCCACCTT CGGCTCCAGC TTCCTCATCA GTGCCTGCTT 1020

CAAGCTTATC CAGGACCTGC TCTCCTTCAT CAATCCACAG CTGCTCAGCA TCCTGATCAG 1080 GTTTATCTCC AACCCCATGG CCCCCTCCTG GTGGGGCTTC CTGGTGGCTG GGCTGATGTT 1140 CCTGTGCTCC ATGATGCAGT CGCTGATCTT ACAACACTAT TACCACTACA TCTTTGTGAC 1200 TGGGGTGAAG TTTCGTACTG GGATCATGGG TGTCATCTAC AGGAAGGCTC TGGTTATCAC 1260 CAACTCAGTC AAACGTGCGT CCACTGTGGG GGAAATTGTC AACCTCATGT CAGTGGATGC 1320 CCAGCGCTTC ATGGACCTTG CCCCCTTCCT CAATCTGCTG TGGTCAGCAC CCCTGCAGAT 1380 CATCCTGGCG ATCTACTTCC TCTGGCAGAA CCTAGGTCCC TCTGTCCTGG CTGGAGTCGC 1440 TTTCATGGTC TTGCTGATTC CACTCAACGG AGCTGTGGCC GTGAAGATGC GCGCCTTCCA 1500 GGTAAAGCAA ATGAAATTGA AGGACTCGCG CATCAAGCTG ATGAGTGAGA TCCTGAACGG 1560 CATCAAGGTG CTGAAGCTGT ACGCCTGGGA GCCCAGCTTC CTGAAGCAGG TGGAGGGCAT 1620 CAGGCAGGGT GAGCTCCAGC TGCTGCGCAC GGCGGCCTAC CTCCACACCA CAACCACCTT 1680 CACCTGGATG TGCAGCCCCT TCCTGGTGAC CCTGATCACC CTCTGGGTGT ACGTGTACGT 1740 GGACCCAAAC AATGTGCTGG ACGCCGAGAA GGCCTTTGTG TCTGTGTCCT TGTTTAATAT 1800 CTTAAGACTT CCCCTCAACA TGCTGCCCCA GTTAATCAGC AACCTGACTC AGGCCAGTGT 1860 GTCTCTGAAA CGGATCCAGC AATTCCTGAG CCAAGAGGAA CTTGACCCCC AGAGTGTGGA 1920 AAGAAAGACC ATCTCCCCAG GCTATGCCAT CACCATACAC AGTGGCACCT TCACCTGGGC 1980 CCAGGACCTG CCCCCCACTC TGCACAGCCT AGACATCCAG GTCCCGAAAG GGGCACTGGT 2040 GGCCGTGGTG GGGCCTGTGG GCTGTGGGAA GTCCTCCCTG GTGTCTGCCC TGCTGGGAGA 2100 GATGGAGAAG CTAGAAGGCA AAGTGCACAT GAAGGGCTCC GTGGCCTATG TGCCCCAGCA 2160 GGCATGGATC CAGAACTGCA CTCTTCAGGA AAACGTGCTT TTCGGCAAAG CCCTGAACCC 2220 CAAGCGCTAC CAGCAGACTC TGGAGGCCTG TGCCTTGCTA GCTGACCTGG AGATGCTGCC 2280 TGGTGGGGAT CAGACAGAGA TTGGAGAGAA GGGCATTAAC CTGTCTGGGG GCCAGCGGCA 2340 GCGGGTCAGT CTGGCTCGAG CTGTTTACAG TGATGCCGAT ATTTTCTTGC TGGATGACCC 2400 ACTGTCCGCG GTGGACTCTC ATGTGGCCAA GCACATCTTT GACCACGTCA TCGGGCCAGA 2460 AGGCGTGCTG GCAGGCAAGA CGCGAGTGCT GGTGACGCAC GGCATTAGCT TCCTGCCCCA 2520 GACAGACTTC ATCATTGTGC TAGCTGATGG ACAGGTGTCT GAGATGGGCC CGTACCCAGC 2580 CCTGCTGCAG CGCAACGGCT CCTTTGCCAA CTTTCTCTGC AACTATGCCC CCGATGAGGA 2640 CCAAGGGCAC CTGGAGGACA GCTGGACCGC GTTGGAAGGT GCAGAGGATA AGGAGGCACT 2700 GCTGATTGAA GACACACTCA GCAACCACAC GGATCTGACA GACAATGATC CAGTCACCTA 2760 TGTGGTCCAG AAGCAGTTTA TGAGACAGCT GAGTGCCCTG TCCTCAGATG GGGAGGGACA 2820 GGGTCGGCCT GTACCCCGGA GGCACCTGGG TCCATCAGAG AAGGTGCAGG TGACAGAGGC 2880 GAAGGCAGAT GGGGCACTGA CCCAGGAGGA GAAAGCAGCC ATTGGCACTG TGGAGCTCAG 2940 TGTGTTCTGG GATTATGCCA AGGCCGTGGG GCTCTGTACC ACGCTGGCCA TCTGTCTCCT 3000 GTATGTGGGT CAAAGTGCGG CTGCCATTGG AGCCAATGTG TGGCTCAGTG CCTGGACAAA 3060 TGATGCCATG GCAGACAGTA GACAGAACAA CACTTCCCTG AGGCTGGGCG TCTATGCTGC 3120 TTTAGGAATT CTGCAAGGGT TCTTGGTGAT GCTGGCAGCC ATGGCCATGG CAGCGGGTGG 3180 CATCCAGGCT GCCCGTGTGT TGCACCAGGC ACTGCTGCAC AACAAGATAC GCTCGCCACA 3240 GTCCTTCTTT GACACCACAC CATCAGGCCG CATCCTGAAC TGCTTCTCCA AGGACATCTA 3300 TGTCGTTGAT GAGGTTCTGG CCCCTGTCAT CCTCATGCTG CTCAATTCCT TCTTCAACGC 3360 CATCTCCACT CTTGTGGTCA TCATGGCCAG CACGCCGCTC TTCACTGTGG TCATCCTGCC 3420 CCTGGCTGTG CTCTACACCT TAGTGCAGCG CTTCTATGCA GCCACATCAC GGCAACTGAA 3480 GCGGCTGGAA TCAGTCAGCC GCTCACCTAT CTACTCCCAC TTTTCGGAGA CAGTGACTGG 3540 TGCCAGTGTC ATCCGGGCCT ACAACCGCAG CCGGGATTTT GAGATCATCA GTGATACTAA 3600 GGTGGATGCC AACCAGAGAA GCTGCTACCC CTACATCATC TCCAACCGGT GGCTGAGCAT 3660 CGGAGTGGAG TTCGTGGGGA ACTGCGTGGT GCTCTTTGCT GCACTATTTG CCGTCATCGG 3720 GAGGAGCAGC CTGAACCCGG GGCTGGTGGG CCTTTCTGTG TCCTACTCCT TGCAGGTGAC 3780 ATTTGCTCTG AACTGGATGA TACGAATGAT GTCAGATTTG GAATCTAACA TCGTGGCTGT 3840 GGAGAGGGTC AAGGAGTACT CCAAGACAGA GACAGAGGCG CCCTGGGTGG TGGAAGGCAG 3900 CCGCCCTCCC GAAGGTTGGC CCCCACGTGG GGAGGTGGAG TTCCGGAATT ATTCTGTGCG 3960 CTACCGGCCG GGCCTAGACC TGGTGCTGAG AGACCTGAGT CTGCATGTGC ACGGTGGCGA 4020 GAAGGTGGGG ATCGTGGGCC GCACTGGGGC TGGCAAGTCT TCCATGACCC TTTGCCTGTT 4080 CCGCATCCTG GAGGCGGCAA AGGGTGAAAT CCGCATTGAT GGCCTCAATG TGGCAGACAT 4140 CGGCCTCCAT GACCTGCGCT CTCAGCTGAC CATCATCCCG CAGGACCCCA TCCTGTTCTC 4200 GGGGACCCTG CGCATGAACC TGGACCCCTT CGGCAGCTAC TCAGAGGAGG ACATTTGGTG 4260 GGCTTTGGAG CTGTCCCACC TGCACACGTT TGTGAGCTCC CAGCCGGCAG GCCTGGACTT 4320 CCAGTGCTCA GAGGGCGGGG AGAATCTCAG CGTGGGCCAG AGGCAGCTCG TGTGCCTGGC 4380 CCGAGCCCTG CTCCGCAAGA GCCGCATCCT GGTTTTAGAC GAGGCCACAG CTGCCATCGA 4440 CCTGGAGACT GACAACCTCA TCCAGGCTAC CATCCGCACC CAGTTTGATA CCTGCACTGT 4500 CCTGACCATC GCACACCGGC TTAACACTAT CATGGACTAC ACCAGGGTCC TGGTCCTGGA 4560 CAAAGGAGTA GTAGCTGAAT TTGATTCTCC AGCCAACCTC ATTGCAGCTA GAGGCATCTT 4620 CTACGGGATG GCCAGAGATG CTGGACTTGC CTAAAATATA TTCCTGAGAT TTCCTCCTGG 4680 CCTTTCCTGG TTTTCATCAG GAAGGAAATG ACACCAAATA TGTCCGCAGA ATGGACTTGA 4740 TAGCAAACAC TGGGGGCACC TTAAGATTTT GCACCTGTAA AGTGCCTTAC AGGGTAACTG 4800 TGCTGAATGC TTTAGATGAG GAAATGATCC CCAAGTGGTG AATGACACGC CTAAGGTCAC 4860 AGCTAGTTTG AGCCAGTTAG ACTAGTCCCC CGGTCTCCCG ATTCCCAACT GAGTGTTATT 4920 TGCACACTGC ACTGTTTTCA AATAACGATT TTATGAAATG ACCTCTGTCC TCCCTCTGAT 4980 TTTTCATATT TTCCTAAAGT TTCGTTTCTG TTTTTTAATA AAAAGCTTTT TCCTCCTGGA 5040 ACAGAAGACA GCTGCTGGGT CAGGCCACCC CTAGGAACTC AGTCCTGTAC TCTGGGGTGC 5100 TGCCTGAATC CATTAAAAAT GGGAGTACTG ATGAAATAAA ACTACATGGT CAACAGTAAA 5160 AAAAAAAAAA AAAAAA 5176 Seq ID NO : 127 DNA Sequence Nucleic Acid Accession # : Nom 002701. 1 Coding sequence : 102.. 899 1 11 21 31 41 51 GTAGTCCTTT GTTACATGCA TGAGTCAGTG AACAGGGAAT GGGTGAATGA CATTTGTGGG 60 TAGGTTATTT CTAGAAGTTA GGTGGGCAGC TCGGAAGGCA GATGCACTTC TACAGACTAT 120 TCCTTGGGGC CACACGTAGG TTCTTGAATC CCGAATGGAA AGGGGAGATT GATAACTGGT 180 GTGTTTATGT TCTTACAAGT CTTCTGCCTT TTAAAATCCA GTCCCAGGAC ATCAAAGCTC 240 TGCAGAAAGA ACTCGAGCAA TTTGCCAAGC TCCTGAAGCA GAAGAGGATC ACCCTGGGAT 300 ATACACAGGC CGATGTGGGG CTCACCCTGG GGGTTCTATT TGGGAAGGTA TTCAGCCAAA 360 CGACCATCTG CCGCTTTGAG GCTCTGCAGC TTAGCTTCAA GAACATGTGT AAGCTGCGGC 420 CCTTGCTGCA GAAGTGGGTG GAGGAAGCTG ACAACAATGA AAATCTTCAG GAGATATGCA 480

AAGCAGAAAC CCTCGTGCAG GCCCGAAAGA GAAAGCGAAC CAGTATCGAG AACCGAGTGA 540 GAGGCAACCT GGAGAATTTG TTCCTGCAGT GCCCGAAACC CACACTGCAG CAGATCAGCC 600 ACATCGCCCA GCAGCTTGGG CTCGAGAAGG ATGTGGTCCG AGTGTGGTTC TGTAACCGGC 660 GCCAGAAGGG CAAGCGATCA AGCAGCGACT ATGCACAACG AGAGGATTTT GAGGCTGCTG 720 GGTCTCCTTT CTCAGGGGGA CCAGTGTCCT TTCCTCTGGC CCCAGGGCCC CATTTTGGTG 780 CCCCAGGCTA TGGGAGCCCT CACTTCACTG CACTGTACTC CTCGGTCCCT TTCCCTGAGG 840 GGGAAGCCTT TCCCCCTGTC TCTGTCACCA CTCTGGGCTC TCCCTTGCAT TCAAACTGAG 900 GTGCCTGCCT GCCCTTCTAG GAATGGGGGA CAGGGGGAGG GGAGGAGCTA GGGAAAGAAA 960 ACCTGGAGTT TGTGCCAGGG TTTTTGGATT AAGTTCTTCA TTCACTAAGG AAGGAATTGG 1020 GAACACAAAG GGTGGGGGCA GGGGAGTTTG GGGCAACTGG TTGGAGGGAA GGTGAAGTTC 1080 AATGATGCTC TTGATTTTAA TCCCACATCA TGTATCACTT TTTTCTTAAA TAAAGAAGCT 1140 TGGGACACAG TAGATAGA 1158 Seq ID NO : 128 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 AAATAAGTAT ATCTGTCAAA AATCATATTT TTATGAGATG TGTCAATACT GGTCTCGTGT 60 CATTTAGGCT ACTTGGAAAA AAGATAAAAA AAATCCTGTT TGGCTCCAAA AAGGAAAAAT 120 CAGCCCCTCC TGCATGAGTG GGAGCTGCAA CCCTTTAGAA CTGATAATCA CAAACCCCTC 180 AGAACCAAAG TGAAATGAAG GAAAATATGT AACATTAGGC ATTGATGGAA GAGGACTAGA 240 TCCTAGTGTA AGCATCCTAA TAAAAGGAGG GGTTCAAAGA TGCTCTCCAG AACCAGTATT 300 TCAGACTTCC TATGATAAAC TAAATGTGCC AGTACCAGAG ACTCCAGGAA AAACCAGAAA 360 TTTGTTTTTG CAATTAGCCG AGCATGTAGT CCAGTCTTTA AATGTCAATT CATGTTATGT 420 TTGTGGAAAA ACTGTAGTAA GAGTTTCCAT AAGAAGAACT TCCATAAGAA GCCCAAGAAT 480 TAGTTCCTAC AGACCCAGTT CCTGATGAAT TCCCAGCCCA AAAGAACCAC CCTGACAATT 540 TTTAGGTTCT AAAAGTCTGA ATTATTAGAC AGTATTGCAT AGCTAGAGAA GGAAAAGGAT 600 TCACTCATCC TATAAGGCGG CTTAGTTGTC TTAGGCAAAA GCTGTATAAT GGTACCACAA 660 ATACAGTTAC ATGGTGGAGT TCCAATTACA CAGAAAGAGA TCCATTCAGT CAATTTCCAA 720 GGTTGCAGAC TGCTTGGGCC CACCCAGAAT TCCACCGGGA CTGGACGGCC CCCACCAGGT 780 TATACTGGAT ATGTGGGCAC AGAGCTTATG CTAAGCTGCC TGATCAGTGG ACAGGTAGCT 840 GTGTAATTGA CACCATTAAA CCATCTTTCT TCTTACTGCC CATAAAAGCA GGGGAACTTC 900 TGGGCTTCCC AGTCTATGCT TCCCGCAAAA AACAAAGCAT AGCCATAGGT GATTGGAAAG 960 ATGATAAATG GCCCCCTGAA AGAATCATAC AATACTATGG ACCCACCACT TGGGCACAAG 1020 ATGACTCTTG GGGATATCGG ACCCCCATCT ACATGCTCAA CGGAATCATA CGGTTACAAG 1080 CTGTTTTCGA AATTATTACT AATACAACCG GTCAAGCCTT GACTGTTCTT GCCCAGCAGG 1140 AGACTCTGAT GAGAAATGCT ATCTATCAAA ATAGACTAGC TCTTGACTAC TTGCTAGCAG 1200 CTGAAAGAGA AGTTTGTGAA AAATTTAACT TTACTAATTG TTTTCTACAC ACAGGTGATC 1260 AAGGGCAAGT AGTTAAAAAT ATAGTTAAAG ATATAACAAA ACTGGCACAT GTACCCATAC 1320 AAGTGTGGCA CGGACTCAAT CCAGGATCCA TGTTTAAAAA TTAGTTCCCA GCAATAGGAA 1380 GATTTAAAAC TCTTATAATA GGAGTTATAA TAGTAATAAA AACCTGCTTA CTGCTCCCTT 1440 GTTTACTACT TTTACTTCTA CAAATGATAA AAAGCTTCAT TGCTACCTTA GTTCACCAAA 1500 ATGCTTCAGC ACAAGTGTAC TATATGAATC ACTATCAATC TATTGCACAA AAAGACATAA 1560 GTAGCAAAAA TAAGAGTGAG AACTCCCACT AATAAAAAGT GAGAGTCTCA AAGGGGGAAA 1620 ATGAGGAAAG AGAGCGACCC TCTCATATTG TTCTATATTG TTTTATACTC AGTACCTGTT 1680 TTAAGGAAAA AACAACAAGG AAGTAAAATC AAAGACAGGC AGCCCAGCGC CAGGCCCAAA 1740 ACCAGGCCTG GGCCTGCCTG GCCTAAACCC AGTAGTTAAA AATCAACTCA TAACTTAGAA 1800 ACTGATGTTA TTCATAGATT CCAGACATTG TATAGAAGAA CATTGTGTAA CTCCCTGCCC 1860 TGTTCTGTTT CTCTCTGACT GCCGGTGCAT GCAGCCCCTG TCACGTACCG CCTGCTTGCT 1920 CAAATCAATC ACGACCCTTT CATGTGAAAT GTTTAGTGTT GTGAGCCCTT AAAAGGGACA 1980 GAAATCGTGC ACTCGGGGAG CTCAGATTTT AAGGCAGTAG TTTGCTGATG CTCCCAGCTG 2040 AATAAAGCCC TTCCTTCTAC AAAAAAAA 2068 Seq ID NO : 129 DNA Sequence Nucleic Acid Accession # : Eos sequence 1 11 21 31 41 51 TTTTTTTTTT TTTTTTTTTT TTTCCTGTAA CACTTTATGT TTATTAGCAG TCTGGTTTTA 60 GCCTAAAAGT CACAACTTTT TTGGAAGTTT TCCCTAACCA GTCACCCCAG ATTAGGCACA 120 TGCCTCTAGG TTAGAGTCCT GTCACCAGAG ATTGATCACA CTTGATTGTG ATTGTTAGAC 180 AACTGTCTCA TTCAATAGAC. TGTCAGTTTC TGGAGGGCAG AGATCTTGTC TCTGTTGTTC 240 CTCTTTTAAT CCCCAGTGTC TAGCATCTCA GAGACACTTG TTGAATGAAT TCATTAACGA 300 CTGGCTGAAT AATGAGCAAT TCATGAAAAA ACACTTTATA TTCACAGGTT TTGGGTAAGA 360 CAGTAGCTCC CTTAAAACAC ACACACACTC TTCATGGTAT GTCACAGAAC TACAGTCTAC 420 ACTCAGTGCA AAGGGTTTCA AAATCCAGTA GGAAGGACAA ATATTGTCCC TCTTCTGTCC 480 TTGGAGAAGA TATTGTGCAA GTGTGGAGTT CTCCTGGAGA AATATTCTTT TTTTTTCTTT 540 GAGATGGAGT TTCACTCTTG TTGCCCAGGC TGGAGTGCAA TGGCACGATC TTAGCTCACT 600 GCAACCTCTG CCTCATGGGT TGAAGCAATT CAAGACCTGC CTTAGCCTCC TGGGTAGCTG 660 GAATTACAAG CACCCACCAC CACATCCAGC TAATTTTTTG TAATTTCAGT AGAGATGGGG 720 TTTCACTATA TTGGCCAGGC TGGTCTCGAA CTCCTGACTT CAGACAATCC ACCCGCCTCA 780 ATCTCCCAAA GTGCT 795 Seq ID NO : 130 DNA Sequence Nucleic Acid Accession # : Nom 005458. 1 Coding sequence : 461.. 3286 1 11 21 31 41 51 GCCGCCCCTG AGCAGCCTCG CCTTCGCCTC CCGCGTTTCC TGCCGTCCGC CCTCCCCCGG 60 CCGAGCTCCA GGGGCTGCCG CCTAGCAGCT CCCGGCGGGA GAGCGGTTCA GAGCGCGCAC 120 GGGGGCGGGC GGAGGCGGCC CGGTGCGGGG CGGCCGCGCT GGAGAGAGGC GCGCGCGGAG 180 ACGCCGGCCC CCCTCTCCGC GTTTGCTCGC TTGCTCCCCG CCTCCCGCAC TCCGCTCGCT 240 CCCACCCCTT CCCGGCGTGA TTGATCCGTC ACGGGCGCCG CCGCTGCCGC CGCCGCCGCC 300 GCGGCCGTTC TGAGCCGAGC CGGAACCCTA GCCCGAGACG GAGCCGGGGC CCGGGCCGGC 360 GCCATTGCGC GGGCGCCGCG GGAAGACCTT GGCGCGGGGC GGCGGGCCGG GCCAGGCCAT 420

GCGGGCCGAG TGAGCCGGCG CCCGCAGCCC GCGGCGCGGC ATGGCTTCCC CGCGGAGCTC 480 CGGGCAGCCC GGGCCGCCGC CGCCGCCGCC ACCGCCGCCC GCGCGCCTGC TACTGCTACT 540 GCTGCTGCCG CTGCTGCTGC CTCTGGCGCC CGGGGCCTGG GGCTGGGCGC GGGGCGCCCC 600 CCGGCCGCCG CCCAGCAGCC CGCCGCTCTC CATCATGGGC CTCATGCCGC TCACCAAGGA 660 GGTGGCCAAG GGCAGCATCG GGCGCGGTGT GCTCCCCGCC GTGGAACTGG CCATCGAGCA 720 GATCCGCAAC GAGTCACTCC TGCGCCCCTA CTTCCTCGAC CTGCGGCTCT ATGACACGGA 780 GTGCGACAAC GCAAAAGGGT TGAAAGCCTT CTACGATGCA ATAAAATACG GGCCTAACCA 840 CTTGATGGTG TTTGGAGGCG TCTGTCCATC CGTCACATCC ATCATTGCAG AGTCCCTCCA 900 AGGCTGGAAT CTGGTGCAGC TTTCTTTTGC TGCAACCACG CCTGTTCTAG CCGATAAGAA 960 AAAATACCCT TATTTCTTTC GGACCGTCCC ATCAGACAAT GCGGTGAATC CAGCCATTCT 1020 GAAGTTGCTC AAGCACTACC AGTGGAAGCG CGTGGGCACG CTGACGCAAG ACGTTCAGAG 1080 GTTCTCTGAG GTGCGGAATG ACCTGACTGG AGTTCTGTAT GGCGAGGACA TTGAGATTTC 1140 AGACACCGAG AGCTTCTCCA ACGATCCCTG TACCAGTGTC AAAAAGCTGA AGGGGAATGA 1200 TGTGCGGATC ATCCTTGGCC AGTTTGACCA GAATATGGCA GCAAAAGTGT TCTGTTGTGC 1260 ATACGAGGAG AACATGTATG GTAGTAAATA TCAGTGGATC ATTCCGGGCT GGTACGAGCC 1320 TTCTTGGTGG GAGCAGGTGC ACACGGAAGC CAACTCATCC CGCTGCCTCC GGAAGAATCT 1380 GCTTGCTGCC ATGGAGGGCT ACATTGGCGT GGATTTCGAG CCCCTGAGCT CCAAGCAGAT 1440 CAAGACCATC TCAGGAAAGA CTCCACAGCA GTATGAGAGA GAGTACAACA ACAAGCGGTC 1500 AGGCGTGGGG CCCAGCAAGT TCCACGGGTA CGCCTACGAT GGCATCTGGG TCATCGCCAA 1560 GACACTGCAG AGGGCCATGG AGACACTGCA TGCCAGCAGC CGGCACCAGC GGATCCAGGA 1620 CTTCAACTAC ACGGACCACA CGCTGGGCAG GATCATCCTC AATGCCATGA ACGAGACCAA 1680 CTTCTTCGGG GTCACGGGTC AAGTTGTATT CCGGAATGGG GAGAGAATGG GGACCATTAA 1740 ATTTACTCAA TTTCAAGACA GCAGGGAGGT GAAGGTGGGA GAGTACAACG CTGTGGCCGA 1800 CACACTGGAG ATCATCAATG ACACCATCAG GTTCCAAGGA TCCGAACCAC CAAAAGACAA 1860 GACCATCATC CTGGAGCAGC TGCGGAAGAT CTCCCTACCT CTCTACAGCA TCCTCTCTGC 1920 CCTCACCATC CTCGGGATGA TCATGGCCAG TGCTTTTCTC TTCTTCAACA TCAAGAACCG 1980 GAATCAGAAG CTCATAAAGA TGTCGAGTCC ATACATGAAC AACCTTATCA TCCTTGGAGG 2040 GATGCTCTCC TATGCTTCCA TATTTCTCTT TGGCCTTGAT GGATCCTTTG TCTCTGAAAA 2100 GACCTTTGAA ACACTTTGCA CCGTCAGGAC CTGGATTCTC ACCGTGGGCT ACACGACCGC 2160 TTTTGGGGCC ATGTTTGCAA AGACCTGGAG AGTCCACGCC ATCTTCAAAA ATGTGAAAAT 2220 GAAGAAGAAG ATCATCAAGG ACCAGAAACT GCTTGTGATC GTGGGGGGCA TGCTGCTGAT 2280 CGACCTGTGT ATCCTGATCT GCTGGCAGGC TGTGGACCCC CTGCGAAGGA CAGTGGAGAA 2340 GTACAGCATG GAGCCGGACC CAGCAGGACG GGATATCTCC ATCCGCCCTC TCCTGGAGCA 2400 CTGTGAGAAC ACCCATATGA CCATCTGGCT TGGCATCGTC TATGCCTACA AGGGACTTCT 2460 CATGTTGTTC GGTTGTTTCT TAGCTTGGGA GACCCGCAAC GTCAGCATCC CCGCACTCAA 2520 CGACAGCAAG TACATCGGGA TGAGTGTCTA CAACGTGGGG ATCATGTGCA TCATCGGGGC 2580 CGCTGTCTCC TTCCTGACCC GGGACCAGCC CAATGTGCAG TTCTGCATCG TGGCTCTGGT 2640 CATCATCTTC TGCAGCACCA TCACCCTCTG CCTGGTATTC GTGCCGAAGC TCATCACCCT 2700 GAGAACAAAC CCAGATGCAG CAACGCAGAA CAGGCGATTC CAGTTCACTC AGAATCAGAA 2760 GAAAGAAGAT TCTAAAACGT CCACCTCGGT CACCAGTGTG AACCAAGCCA GCACATCCCG 2820 CCTGGAGGGC CTACAGTCAG AAAACCATCG CCTGCGAATG AAGATCACAG AGCTGGATAA 2880 AGACTTGGAA GAGGTCACCA TGCAGCTGCA GGACACACCA GAAAAGACCA CCTACATTAA 2940 ACAGAACCAC TACCAAGAGC TCAATGACAT CCTCAACCTG GGAAACTTCA CTGAGAGCAC 3000 AGATGGAGGA AAGGCCATTT TAAAAAATCA CCTCGATCAA AATCCCCAGC TACAGTGGAA 3060 CACAACAGAG CCCTCTCGAA CATGCAAAGA TCCTATAGAA GATATAAACT CTCCAGAACA 3120 CATCCAGCGT CGGCTGTCCC TCCAGCTCCC CATCCTCCAC CACGCCTACC TCCCATCCAT 3180 CGGAGGCGTG GACGCCAGCT GTGTCAGCCC CTGCGTCAGC CCCACCGCCA GCCCCCGCCA 3240 CAGACATGTG CCACCCTCCT TCCGAGTCAT GGTCTCGGGC CTGTAAGGGT GGGAGGCCTG 3300 GGCCCGGGGC CTCCCCCGTG ACAGAACCAC ACTGGGCAGA GGGGTCTGCT GCAGAAACAC 3360 TGTCGGCTCT GGCTGCGGAG AAGCTGGGCA CCATGGCTGG CCTCTCAGGA CCACTCGGAT 3420 GGCACTCAGG TGGACAGGAC GGGGCAGGGG GAGACTTGGC ACCTGACCTC GAGCCTTATT 3480 TGTGAAGTCC TTATTTCTTC ACAAAGAAGA GGAACGGAAA TGGGACGTCT TCCTTAACAT 3540 CTGCAAACAA GGAGGCGCTG GGATATCAAA CTTGCAAAAA AAAAAAAAAA AAAAAAAAAA 3600 CAAAAAAACT AGACAAGGAG AGAGGCACTA GAACTCCAGC TGGAAGTCAC GGAGTGGCTC 3660 GAGCAGCCTT GGGAAGAGGC AAGGAGCTTC TGAAGAAACT GCCTCTGCAC ACACATCACT 3720 GGCTGTGACC CCTCAGGCTA GCCCTTCTCC ACTCTGGGGG AGGAGGTGGG AAGGGCCACC 3780 AGGCCCCCAG CTGCCAGGCC AGCTGACCCC AGCCTTCCTG GAACAGGGAG TCTGCAGGAG 3840 CGCAGACAGG CACAGCCCTG GAGCAGGCAG GCCGAGGGCT GCGGCACTGG AGCAGGCTGA 3900 CTTACATGCT CCACATGGGA CCTGTGTCAC CCAATGAGAT GTTTGTTACT CTGGTAAATG 3960 CCACACGTTA ACACAATAAC ACCCATTCCT GGGACCGTGG GGATTTAGGG CACGTCACTG 4020 CAGACACGCT CTGCAGCATT CACCGACAGT CTGTCATGCA CCCACCACGT TGGCCATGTC 4080 CTTGTGTTCC TATCGGATGC TCCCAGTAAC CAGGGGGACC ACCCGAGCTA ATCATGGAAT 4140 GTCTGTTCCC AGCAAACACG ATAAAGAAAG ATTGTGCACT TTAACCTCTC TCATCAGGGC 4200 CCAAGGGCTG GCTGGGATTT TTTTTTTTTT TTTCCCACTA ACTTTGTTTC TGACCAAAGT 4260 GAATTGGAGG CACTCTGCTA AAAGACATCC CCGTAGACAT AGGGGAGAGA GTTGCTGGCT 4320 GAGGGCTTCC CTTGGCTTCC AGAAGGCAGC CTTCCATCCA GACAAGCCAG TGAGCTCTCC 4380 CCTTGGGATC ACTGGGGTGA TCAGTCAGCA GATTGATTCT CATTCATAAG ATCATTCCTC 4440 CCTTTAAATT GAGCCCCTAA GAGCACTGGC CTGGGAGTCA GACAGACCTG GGTTCAAGTC 4500 CTCAGTCCCC TGCCCACTCC CTACGTGACT TTGATCAGGT CACTAGTGTC TCTCTGAGCC 4560 TCAGTTTCCC CTCTGTAACT TGGGGTTGAA CTAAAACACC TGTCCTGCCT ACCTCACAAG 4620 GTCACTCTGA GGATTGAAAC TTGATCTTGT CCAGGAAAGC TTTGTACCAA ACAGTGAAGC 4680 CGCCCTGATC CGTGAGGTAT GAGTATGACT CTGACCTTCA GCCCTCCCTA CAGCCGGGGG 4740 TGTGGCCCAG AGAAGCTTCC AGCACAGCCC TCTACCCAGA ACATCCGGGC TGGAGGGAGG 4800 CTCCCAGTGA CTTTTCTGAC ATTCCTAGAC AGGTTCATTC TTTGCTCAAG AAAGGCCTGA 4860 ATGACAATGT CCAGGATGTC TGCACAACTG AGCAGCTCGC TCACTCCCTA AAGAAACCTA 4920 TTGGCAGCTT CAACAGGCAG GCAATAATCT CTTCCCAGAA CCACTGCAGT CAGGAATAAA 4980 CTGTTTTCTC CACCAGGCTT TGACAAAAGG GCCCACAGGA ATCTTACCAA TGCCAACATT 5040 TCAAAGCACC CTATTTCACG TAGCATAGCT TTCTGCTCCC CTTCCCCAAA GAGAGGTTAT 5100 GGAGGTACTG TAGCTTTTAG GGAAAAAAAA ATGTTAACAC ATCACAGGTC AAGTTGAAGT 5160 CATTCTCTGT TTAGGCACTA AAAATCGGTG TTGTCACTCA CTGTGTATTA CCAGTATTTA 5220 CTTGCTTTCT TGATTTCACC AAAACCAAAT TTAATTTAAA GGACCACATT AATTTTTCAA 5280 AGGGAAAGAG ACAATTAATT GTACATAATG TATACACACA CACAAAAAAA AATACCTGTA 5340 GAAATATTAT TCCAGCATAG CAGGAAAACA AACAAAAGTA TTGGACTGTC GGAGGTGAGC 5400 CTGTGCGTCT GTAACCCTTT GTGACTCCTG AGCGTGCGCT GTCTTCTAGG TTAACTCACG 5460

AAGTACATTC TCTGTCTTAC TGATACTGTA GGTTCACCCA TTTTTTTTTA ATTTCCTCGC 5520 AAATAACAAG ACCCACAGAA GTGACTCTAG CTACTTAATG GTTCTGTTCT TTTATATGCA 5580 GCAAACACAC CGTCCATTTC TGAAGAGGCT TCGGCCTGAA GGCATTTTCC AATGATGTTA 5640 GTGCACAAAA CGCTTTAAAT TAGACTGGAA CTGCCAGAAT CAAATGTAAA TGAGGAATTT 5700 CTCGTACCCC TACTGCATGG TATCGATTTT TAATAAATTG TTGCAAATTT GTTTTTATGA 5760 ATAAAAGGAA AAAACCTGTC GTCTTT 5786 Seq ID NO : 131 DNA Sequence Nucleic Acid Accession # : NM 014817 Coding sequence : 247.. 2682 1 11 21 31 41 51 CAGAAATGCA ACAAGTAGTA CCCGGGGTCT GCAGAGCGCC CCGCGCCGCC TGACTTGGCC 60 GGGCGAAGCC CGCCTGCAGA GACCCGGGCC GGCCTCCGGA CAAAGGACGG AGGAGGGGCT 120 GGACGGCGCT GCGAAGTCCG AAAGAGGCCA TTTAGCGACT CTGGCCAGGC TAAGGGGAAT 180 GCAGAGGAGA CACAGAGCCG GCGGGCCAAG AGGACGATCC GGCCGCTGCA CGCAGGGCGG 240 GAGGCGATGG AGGCTGCCCG CGCCTTGCGC CTCCTGCTCG TGGTGTGCGG CTGCCTCGCG 300 CTCCCGCCGC TGGCCGAGCC CGTGTGCCCG GAGCGCTGCG ACTGCCAGCA TCCCCAGCAT 360 CTCCTGTGCA CCAACAGGGG GCTCCGCGTA GTGCCCAAGA CCAGCTCGCT GCCGAGCCCC 420 CACGACGTGC TCACCTACAG CCTCGGCGGC AACTTCATAA CCAACATCAC GGCCTTCGAC 480 TTCCACCGTC TGGGGCAGCT CAGACGGCTG GACCTGCAGT ACAACCAGAT CCGCTCTCTG 540 CACCCCAAGA CCTTCGAGAA GCTCTCGCGG CTGGAAGAGC TGTACCTGGG GAACAACCTC 600 TTGCAGGCGC TCGCCCCGGG CACGCTGGCC CCGCTGCGCA AGCTGCGCAT CCTCTACGCC 660 AACGGGAACG AGATCAGCCG CCTAAGCCGC GGCTCCTTCG AGGGCCTGGA GAGTCTAGTC 720 AAGCTGCGGC TGGACGGGAA CGCCCTGGGG GCGCTGCCGG ACGCGGTCTT CGCTCCCTTG 780 GGCAACCTGC TCTACCTACA TCTGGAGTCC AACCGGATCC GCTTTCTGGG CAAGAACGCC 840 TTCGCCCAGC TAGGCAAGCT GCGCTTCCTC AACCTCTCTG CCAACGAGCT ACAGCCCTCC 900 CTGCGCCACG CGGCCACCTT CGCACCGCTG CGCTCCCTCT CCTCCCTCAT CCTCTCGGCC 960 AACAGCCTGC AGCACCTCGG GCCGCGCATC TTCCAGCACC TGCCACGTCT CGGCCTGCTC 1020 TCGCTCAGGG GCAACCAGCT CACGCACCTC GCGCCTGAGG CCTTTTGGGG CTTGGAGGCC 1080 CTGCGCGAGC TGCGCCTGGA GGGTAATCGG CTGAGCCAGC TGCCAACTGC GCTGCTGGAG 1140 CCTCTGCACA GCCTGGAGGC GCTGGACCTG AGCGGCAATG AGCTGTCCGC CCTGCACCCG 1200 GCCACCTTCG GCCACCTGGG CCGGCTGCGC GAGCTCAGCC TGCGCAACAA CGCGCTCAGC 1260 GCCCTATCCG GGGACATCTT CGCCGCCAGC CCAGCCCTTT ATCGGCTGGA TCTAGACGGC 1320 AACGGCTGGA CCTGCGACTG CCGGCTGCGA GGCCTGAAGC GCTGGATGGG CGACTGGCAC 1380 TCGCAGGGCC GGCTCCTCAC TGTCTTCGTG CAGTGTCGCC ACCCCCCGGC CCTGCGAGGC 1440 AAATACCTGG ATTACCTGGA TGACCAGCAG CTGCAAAATG GATCCTGCGC GGATCCCTCG 1500 CCCTCAGCTT CCCTGACCGC TGACCGCAGG CGGCAGCCCC TACCCACGGC CGCAGGGGAG 1560 GAGATGACGC CACCTGCAGG TCTCGCGGAG GAGCTGCCGC CGCAGCCGCA GCTCCAGCAG 1620 CAGGGGCGAT TTCTAGCTGG GGTGGCCTGG GATGGGGCCG CCAGGGAGCT GGTAGGCAAC 1680 CGCAGCGCTC TAAGGCTGAG TCGGCGGGGC CCGGGCCTCC AGCAGCCCAG CCCCTCCGTC 1740 GCTGCCGCCG CGGGCCCGGC TCCACAGTCC CTAGACCTGC ACAAGAAGCC CCAGCGGGGC 1800 CGTCCGACTC GGGCAGATCC CGCCCTCGCG GAGCCCACCC CAACGGCCTC TCCTGGCTCT 1860 GCGCCATCGC CCGCCGGCGA CCCCTGGCAG CGCGCGACGA AGCATCGTCT GGGCACGGAG 1920 CACCAGGAGC GTGCCGCCCA GTCCGACGGT GGGGCCGGGC TGCCGCCGCT GGTGTCCGAC 1980 CCATGCGACT TCAACAAGTT CATTCTGTGC AACCTGACGG TGGAGGCGGT GGGCGCAGAC 2040 AGCGCCTCGG TGCGCTGGGC CGTGCGCGAG CACCGCAGTC CCCGGCCGCT GGGCGGCGCG 2100 CGCTTCCGCC TGCTCTTTGA CCGCTTTGGC CAGCAGCCCA AGTTCCACCG CTTCGTCTAC 2160 CTGCCTGAGA GCAGCGACTC GGCCACGCTG CGCGAGCTGC GCGGGGACAC CCCCTACCTG 2220 GTGTGCGTGG AGGGCGTGCT TGGGGGCCGT GTCTGCCCTG TGGCTCCCCG GGACCACTGC 2280 GCGGGGCTGG TCACCCTACC GGAGGCCGGG AGCCGGGGCG GCGTCGACTA CCAGCTGCTG 2340 ACCTTGGCCC TGCTGACGGT CAACGCGCTG CTGGTGCTCC TGGCCTTGGC GGCCTGGGCG 2400 TCTCGCTGGC TGCGTAGGAA ACTGCGGGCT AGGCGGAAGG GCGGGGCCCC GGTCCACGTT 2460 CGGCACATGT ACTCCACCCG ACGGCCCCTG CGCTCCATGG GCACCGGCGT GTCCGCCGAC 2520 TTCTCGGGAT TCCAGTCGCA CCGGCCACGC ACCACCGTGT GCGCGCTCAG TGAGGCGGAC 2580 CTCATCGAAT TCCCCTGCGA CCGCTTCATG GACAGTGCGG GCGGCGGCGC GGGCGGCAGC 2640 CTGAGACGGG AGGACCGTCT CCTGCAGCGA TTTGCCGACT AGGTCCAGGG CATATAGAGA 2700 CCATCTCATT GGCCCTAAGG AGCCGCCTCT CCGTGAGGCC CACCAGCCCA CCTCAGGGGA 2760 AGTGCCGTTT TGTGCACTTG CCAGAGAGGC CGGTGGGGAC AGAGGGCCAA TTCGGGCACC 2820 ATCCCCCAAT TCCCAATACT CGAGAAGTAA ATGGATGGTA CTTGGTGGTC AGAGCCAGAG 2880 TAGGGGACAA ATGGATGGTG GGATGCTGAG GTCGGAGGCT TCGCTTGGAG GCTTTGACAC 2940 AGCTATGCGA ATGGCTTTTG TAGCACTGCA ATGCAGAAGC CAGGCTTTGG GGGTAGAAAG 3000 GGGGTGCTTG TGCCCCCAAC ATGGCCAGAA ATATTTGGGT GCATGCTTTT TGTTTGCTCA 3060 GTGTCAAACA GAGAAGTTTT GTTTCTATTT AAGGAAGGAA CTTATTACCA TTACAAAGGA 3120 GGCTTGGCCA GGGACTCCAC TGGTTTGGTG ATCTCTGCCA AGAAGGGGGA TGTAAACAGG 3180 TGGTAAAGTT TAACATACCC GCCAAGGAAC TCGTTTATGT TGGCTGATAG AGCATTCAGG 3240 ATACCTTAAA GTTTAATAAG AGACGCATTT TTTTTTTTCA AAAATGTGAA AAGCTCTGAC 3300 ATTTAACGAA CTGACCAATA GACTCAAGGA CTGTTTTAGT TGGACTGGGC CATTTTATTA 3360 TGTTCCTTTT AATATTAACA GTACAAGAGC GCTTGCTGAC TTCGAGGATA ACTAAGATTA 3420 CATACTTTCT CAGGAGAAGG CTGCATGCAA GACTTCTCTG TCAGGGTTGC TCCTGTGGCT 3480 TTTTTAATTT TATTTTTTTA AACCTATATA TGGAAAAGGA AATTTCAATG CCAGATTTGA 3540 TAAAAGAATG TGATGTATAT GTAGCTGATG ACCCACTGGG GAACACCAGT GTTCCAGTTC 3600 ACTTACCACA TCTGTGACAG TGTGTTTAGA TTGGAATAAA TGTGATGCAT TACTTCTTAT 3660 GTTTTTATCA GTGACATGGT TGACTGTGCC CTAATTCTCT TGAGTTGCAG TTAAGCAATG 3720 AAGGTTATTT CCTAATAGGG AAGCAAAAGG TGATTGTCAA TTGATAGTTT AATGTTTGAC 3780 CACATTAGTG TCTTTATATG AAATAGTAGA GGGGAAGAAA TTATAGAAAA CAAATGTGAA 3840 AAAAATACAC CAGTGGGTAT CTGTTCTACT AAAACCAGAA GATTGTTATG AGTACTTAAA 3900 CCTCACTGTG AAATAATGAT ATATTTTGCA ATTAATCCCT CCCCAACTGA GTGTCTTACT 3960 GTGTTATTAA ATCTTATCTT TTAGTTAATA GTTGCAGTAT TTCTTTTAAA TGTTTTTGTT 4020 TTAAACTTAG GGGTAGGATC CTTTATTTGT TCAGTTGTTT CCAACTATTT GGGATACTTT 4080 CATTCCCTGC TATTTATGAA GTACATGTTT ATCACTAAGT GTAGTGGTTT GGTTTACATT 4140 AATAATTTTA TGTGTGGTCT AAAAATGCAG TCACTAAGAG AATGTACACT GTGGTTATGG 4200 TCACAGTGGT TATGGATTTA TTGGCAGTGG AGTACCATGG AGGTCACTGC AATGGTGCTA 4260 AGGCTGACAG TGGAATCTTC TGTTTAGGGC CTTAAGCCCC TGAGGGTCCT GGTGACTCAG 4320

GGAATCCATC ACAGCCCCGG GTCTTTCACC CCAGTTCACT CCTTTTATGT TTGGCCTAGA 4380 TTGACCCATG CCTGCCCTCT TCTCAACAGC TGAGTAGGGA ACCAGCCATC TGAATGAGCT 4440 GATCGTTGTT TATGTTCAAA TGAGTAAATG TCCAGACCAC TTAAAACTAC AGCTGCTTTT 4500 CTGGCAGTCT CGTCTGCGGG GCCAAAACTT AATAAACCAC AGGAAATAGA CTGTCATTCT 4560 TAGTTTGCTG CCAGGGCTTA TTTTAGATTG AGAGCATACT GGTACATGAG AGCAGTAGTG 4620 TTGTTTGCTC TTATTTTCAA CCAGGGAGCT ATCTGGCACC TTTTGTGCTC CTGGCTTTTT 4680 TCAATCATAG CACTATTGCA TCTCCTAGCT ATTTCTTTTG CCCAGCAGGG TAATATTGAG 4740 TCCCATTGCA AGTATGGACA AGGCCTCTGG TTCTCCTCAC CACCCACCTT TTCAGCCATA 4800 GAACATCACT GAAAATGCCT AATGCCTGGA TCTGTGTTCT ACTTTAGTTT CACTGGGAAG 4860 TCTTTCAGTG GGAGATGAAT AAATGTTATA CATTGTTATG TCCAGTTATG TCAATAAACC 4920 CACTAATAGA GAT 4933 Seq ID NO : 132 DNA Sequence Nucleic Acid Accession # NM001792. 2 Coding sequence : 206.. 2926 1 11 21 31 41 51 TTTGTCATCA GCTCGCTCTC CATTGGCGGG GAGCGGAGAG CAGCGAAGAA GGGGGTGGGG 60 AGGGGAGGGG AAGGGAAGGG GGTGGAAACT GCCTGGAGCC GTTTCTCCGC GCCGCTGTTG 120 GTGCTGCCGC TGCCTCCTCC TCCTCCGCCG CCGCCGCCGC CGCCGCCGCC TCCTCCGGCT 180 CTTCGCTCGG CCCCTCTCCG CCTCCATGTG CCGGATAGCG GGAGCGCTGC GGACCCTGCT 240 GCCGCTGCTG GCGGCCCTGC TTCAGGCGTC TGTAGAGGCT TCTGGTGAAA TCGCATTATG 300 CAAGACTGGA TTTCCTGAAG ATGTTTACAG TGCAGTCTTA TCGAAGGATG TGCATGAAGG 360 ACAGCCTCTT CTCAATGTGA AGTTTAGCAA CTGCAATGGA AAAAGAAAAG TACAATATGA 420 GAGCAGTGAG CCTGCAGATT TTAAGGTGGA TGAAGATGGC ATGGTGTATG CCGTGAGAAG 480 CTTTCCACTC TCTTCTGAGC ATGCCAAGTT CCTGATATAT GCCCAAGACA AAGAGACCCA 540 GGAAAAGTGG CAAGTGGCAG TAAAATTGAG CCTGAAGCCA ACCTTAACTG AGGAGTCAGT 600 GAAGGAGTCA GCAGAAGTTG AAGAAATAGT GTTCCCAAGA CAATTCAGTA AGCACAGTGG 660 CCACCTACAA AGGCAGAAGA GAGACTGGGT CATCCCTCCA ATCAACTTGC CAGAAAACTC 720 CAGGGGACCT TTTCCTCAAG AGCTTGTCAG GATCAGGTCT GATAGAGATA AAAACCTTTC 780 ACTGCGGTAC AGTGTAACTG GGCCAGGAGC TGACCAGCCT CCAACTGGTA TCTTCATTAT 840 CAACCCCATC TCGGGTCAGC TGTCGGTGAC AAAGCCCCTG GATCGCGAGC AGATAGCCCG 900 GTTTCATTTG AGGGCACATG CAGTAGATAT TAATGGAAAT CAAGTGGAGA ACCCCATTGA 960 CATTGTCATC AATGTTATTG ACATGAATGA CAACAGACCT GAGTTCTTAC ACCAGGTTTG 1020 GAATGGGACA GTTCCTGAGG GATCAAAGCC TGGAACATAT GTGATGACCG TAACAGCAAT 1080 TGATGCTGAC GATCCCAATG CCCTCAATGG GATGTTGAGG TACAGAATCG TGTCTCAGGC 1140 TCCAAGCACC CCTTCACCCA ACATGTTTAC AATCAACAAT GAGACTGGTG ACATCATCAC 1200 AGTGGCAGCT GGACTTGATC GAGAAAAAGT GCAACAGTAT ACGTTAATAA TTCAAGCTAC 1260 AGACATGGAA GGCAATCCCA CATATGGCCT TTCAAACACA GCCACGGCCG TCATCACAGT 1320 GACAGATGTC AATGACAATC CTCCAGAGTT TACTGCCATG ACGTTTTATG GTGAAGTTCC 1380 TGAGAACAGG GTAGACATCA TAGTAGCTAA TCTAACTGTG ACCGATAAGG ATCAACCCCA 1440 TACACCAGCC TGGAACGCAG TGTACAGAAT CAGTGGCGGA GATCCTACTG GACGGTTCGC 1500 CATCCAGACC GACCCAAACA GCAACGACGG GTTAGTCACC GTGGTCAAAC CAATCGACTT 1560 TGAAACAAAT AGGATGTTTG TCCTTACTGT TGCTGCAGAA AATCAAGTGC CATTAGCCAA 1620 GGGAATTCAG CACCCGCCTC AGTCAACTGC AACCGTGTCT GTTACAGTTA TTGACGTAAA 1680 TGAAAACCCT TATTTTGCCC CCAATCCTAA GATCATTCGC CAAGAAGAAG GGCTTCATGC 1740 CGGTACCATG TTGACAACAT TCACTGCTCA GGACCCAGAT CGATATATGC AGCAAAATAT 1800 TAGATACACT AAATTATCTG ATCCTGCCAA TTGGCTAAAA ATAGATCCTG TGAATGGACA 1860 AATAACTACA ATTGCTGTTT TGGACCGAGA ATCACCAAAT GTGAAAAACA ATATATATAA 1920 TGCTACTTTC CTTGCTTCTG ACAATGGAAT TCCTCCTATG AGTGGAACAG GAACGCTGCA 1980 GATCTATTTA CTTGATATTA ATGACAATGC CCCTCAAGTG TTACCTCAAG AGGCAGAGAC 2040 TTGCGAAACT CCAGACCCCA ATTCAATTAA TATTACAGCA CTTGATTATG ACATTGATCC 2100 AAATGCTGGA CCATTTGCTT TTGATCTTCC TTTATCTCCA GTGACTATTA AGAGAAATTG 2160 GACCATCACT CGGCTTAATG GTGATTTTGC TCAGCTTAAT TTAAAGATAA AATTTCTTGA 2220 AGCTGGTATC TATGAAGTTC CCATCATAAT CACAGATTCG GGTAATCCTC CCAAATCAAA 2280 TATTTCCATC CTGCGCGTGA AGGTTTGCCA GTGTGACTCC AACGGGGACT GCACAGATGT 2340 GGACAGGATT GTGGGTGCGG GGCTTGGCAC CGGTGCCATC ATTGCCATCC TGCTCTGCAT 2400 CATCATCCTG CTTATCCTTG TGCTGATGTT TGTGGTATGG ATGAAACGCC GGGATAAAGA 2460 ACGCCAGGCC AAACAACTTT TAATTGATCC AGAAGATGAT GTAAGAGATA ATATTTTAAA 2520 ATATGATGAA GAAGGTGGAG GAGAAGAAGA CCAGGACTAT GACTTGAGCC AGCTGCAGCA 2580 GCCTGACACT GTGGAGCCTG ATGCCATCAA GCCTGTGGGA ATCCGACGAA TGGATGAAAG 2640 ACCCATCCAC GCTGAGCCCC AGTATCCGGT CCGATCTGCA GCCCCACACC CTGGAGACAT 2700 TGGGGACTTC ATTAATGAGG GCCTTAAAGC GGCTGACAAT GACCCCACAG CTCCACCATA 2760 TGACTCCCTG TTAGTGTTTG ACTATGAAGG CAGTGGCTCC ACTGCTGGGT CCTTGAGCTC 2820 CCTTAATTCC TCAAGTAGTG GTGGTGAGCA GGACTATGAT TACCTGAACG ACTGGGGGCC 2880 ACGGTTCAAG AAACTTGCTG ACATGTATGG TGGAGGTGAT GACTGAACTT CAGGGTGAAC 2940 TTGGTTTTTG GACAAGTACA AACAATTTCA ACTGATATTC CCAAAAAGCA TTCAGAAGCT 3000 AGGCTTTAAC TTTGTAGTCT ACTAGCACAG TGCTTGCTGG AGGCTTTGGC ATAGGCTGCA 3060 AACCAATTTG GGCTCAGAGG GAATATCAGT GATCCATACT GTTTGGAAAA ACACTGAGCT 3120 CAGTTACACT TGAATTTTAC AGTACAGAAG CACTGGGATT TTATGTGCCT TTTTGTACCT 3180 TTTTCAGATT GGAATTAGTT TTCTGTTTAA GGCTTTAATG GTACTGATTT CTGAAACGAT 3240 AAGTAAAAGA CAAAATATTT TGTGGTGGGA GCAGTAAGTT AAACCATGAT ATGCTTCAAC 3300 ACGCTTTTGT TACATTGCAT TTGCTTTTAT TAAAATACAA AATTAAACAA ACAAAAAAAC 3360 TCATGGAGCG ATTTTATTAT CTTGGGGGAT GAGACCATGA GATTGGAAAA TGTACATTAC 3420 TTCTAGTTTT AGACTTTAGT TTGTTTTTTT TTTTTCACTA AAATCTTAAA ACTTACTCAG 3480 CTGGTTGCAA ATAAAGGGAG TTTTCATATC ACCAATTTGT AGCAAAATTG AATTTTTTCA 3540 TAAACTAGAA TGTTAGACAC ATTTTGGTCT TAATCCATGT ACACTTTTTT ATTTCTGTAT 3600 TTTTCCACTT CACTGTAAAA ATAGTATGTG TACATAATGT TTTATTGGCA TAGTCTATGG 3660 AGAAGTGCAG AAACTTCAGA ACATGTGTAT GTATTATTTG GACTATGGAT TCAGGTTTTT 3720 TGCATGTTTA TATCTTTCGT TATGGATAAA GTATTTACAA AACAGTGACA TTTGATTCAA 3780 TTGTTGAGCT GTAGTTAGAA TACTCAATTT TTAATTTTTT TAATTTTTTT ATTTTTTATT 3840 TTCTTTTTGG TTTGGGGAGG GAGAAAAGTT CTTAGCACAA ATGTTTTACA TAATTTGTAC 3900 CAAAAAAAAA AAAAAGGAAA GGAAAGAAAG GGGTGGCCTG ACACTGGTGG CACTACTAAG 3960 TGTGTGTTTT TTAAAAAAAA AAATGGAAAA AAAAAAGCTT TTAAACTGGA GAGACTTCTG 4020

ACAACAGCTT TGCCTCTGTA TTGTGTACCA GAATATAAAT GATACACCTC TGACCCCAGC 4080 GTTCTGAATA AAATGCTAAT TTTGGAAAAA AAAAAAAAAA AA 4122 Seq ID NO : 133 DNA Sequence Nucleic Acid Accession # : Nom 016941. 1 Coding sequence : 8.. 1864 1 11 21 31 41 51 ( GAAGGCCATG GTCTCCCCAC GGATGTCCGG GCTCCTCTCC CAGACTGTGA TCCTAGCGCT 60 CATTTTCCTC CCCCAGACAC GGCCCGCTGG CGTCTTCGAG CTGCAGATCC ACTCTTTCGG 120 GCCGGGTCCA GGCCCTGGGG CCCCGCGGTC CCCCTGCAGC GCCCGGCTCC CCTGCCGCCT 180 CTTCTTCAGA GTCTGCCTGA AGCCTGGGCT CTCAGAGGAG GCCGCCGAGT CCCCGTGCGC 240 CCTGGGCGCG GCGCTGAGTG CGCGCGGACC GGTCTACACC GAGCAGCCCG GAGCGCCCGC 300 GCCTGATCTC CCACTGCCCG ACGGGCTCTT GCAGGTGCCC TTCCGGGACG CCTGGCCTGG 360 CACCTTCTCT TTCATCATCG AAACCTGGAG AGAGGAGTTA GGAGACCAGA TTGGAGGGCC 420 CGCCTGGAGC CTGCTGGCGC GCGTGGCTGG CAGGCGGCGC TTGGCAGCCG GAGGCCCGTG 480 GGCCCGGGAC ATTCAGCGCG CAGGCGCCTG GGAGCTGCGC TTCTCGTACC GCGCGCGCTG 540 CGAGCCGCCT GCCGTCGGGA CCGCGTGCAC GCGCCTCTGC CGTCCGCGCA GCGCCCCCTC 600 GCGGTGCGGT CCGGGACTGC GCCCCTGCGC ACCGCTCGAG GACGAATGTG AGGCGCCGCT 660 GGTGTGCCGA GCAGGCTGCA GCCCTGAGCA TGGCTTCTGT GAACAGCCCG GTGAATGCCG 720 ATGCCTAGAG GGCTGGACTG GACCCCTCTG CACGGTCCCT GTCTCCACCA GCAGCTGCCT 780 CAGCCCCAGG GGCCCGTCCT CTGCTACCAC CGGATGCCTT GTCCCTGGGC CTGGGCCCTG 840 TGACGGGAAC CCGTGTGCCA ATGGAGGCAG CTGTAGTGAG ACACCCAGGT CCTTTGAATG 900 CACCTGCCCG CGTGGGTTCT ACGGGCTGCG GTGTGAGGTG AGCGGGGTGA CATGTGCAGA 960 TGGACCCTGC TTCAACGGCG GCTTGTGTGT CGGGGGTGCA GACCCTGACT CTGCCTACAT 1020 CTGCCACTGC CCACCTGGTT TCCAAGGCTC CAACTGTGAG AAGAGGGTGG ACCGGTGCAG 1080 CCTGCAGCCA TGCCGCAATG GCGGACTCTG CCTGGACCTG GGCCACGCCC TGCGCTGCCG 1140 CTGCCGCGCC GGCTTCGCGG GTCCTCGCTG CGAGCACGAC CTGGACGACT GCGCGGGCCG 1200 CGCCTGCGCT AACGGCGGCA CGTGTGTGGA GGGCGGCGGC GCGCACCGCT GCTCCTGCGC 1260 GCTGGGCTTC GGCGGCCGCG ACTGCCGCGA GCGCGCGGAC CCGTGCGCCG CGCGCCCCTG 1320 TGCTCACGGC GGCCGCTGCT ACGCCCACTT CTCCGGCCTC GTCTGCGCTT GCGCTCCCGG 1380 CTACATGGGA GCGCGGTGTG AGTTCCCAGT GCACCCCGAC GGCGCAAGCG CCTTGCCCGC 1440 GGCCCCGCCG GGCCTCAGGC CCGGGGACCC TCAGCGCTAC CTTTTGCCTC CGGCTCTGGG 1500 ACTGCTCGTG GCCGCGGGCG TGGCCGGCGC TGCGCTCTTG CTGGTCCACG TGCGCCGCCG 1560 TGGCCACTCC CAGGATGCTG GGTCTCGCTT GCTGGCTGGG ACCCCGGAGC CGTCAGTCCA 1620 CGCACTCCCG GATGCACTCA ACAACCTAAG GACGCAGGAG GGTTCCGGGG ATGGTCCGAG 1680 CTCGTCCGTA GATTGGAATC GCCCTGAAGA TGTAGACCCT CAAGGGATTT ATGTCATATC 1740 TGCTCCTTCC ATCTACGCTC GGGAGGTAGC GACGCCCCTT TTCCCCCCGC TACACACTGG 1800 GCGCGCTGGG CAGAGGCAGC ACCTGCTTTT TCCCTACCCT TCCTCGATTC TGTCCGTGAA 1860 ATGAATTGGG TAGAGTCTCT GGAAGGTTTT AAGCCCATTT TCAGTTCTAA CTTACTTTCA 1920 Seq ID NO : 134 DNA Sequence Nucleic Acid Accession t : FGENESH prediction Coding sequence : 1.. 411 1 11 21 31 41 51 ATGTGCCAGG CTTTCCTCTG GGTGCTAGGG ACACTGTGGC TTCTCAAAAA TGCCCGTTGT 60 CTGCAGCCAT ACCCACCTGA ACATGCCCAA TCTTGCCTGA TCTCAGAAGC TAAGCAGGGT 120 CAGGCCCAGT TACCACTTGG ATGGGTGAAG TGGCCCTTGC ACTTGAGGAG CTCACTGTCC 180 AAAAGGTTGG AAAGGAAGTA CCCCAGCCTA TTGAATGGGG AAATTGAAGC ACAGATATGT 240 AAAACATCTT CTCTAGAGTT ACCCAGCTGT GATCTGGTGA CAGCTGATGG TTCCACTGAA 300 GTAACTATCT CGGAAAATCT CCCTGCTGTT GGATTCCATA TCTGTCAACA GCAGGACTCT 360 CATGTAGAAG GCATGGTTAA CATCTCCAAA GCCTCTTCTG GCCAAATGTA G 411 Seq ID NO : 135 DNA Sequence Nucleic Acid Accession # : Nom 024812. 1 Coding sequence : 184.. 621 1 11 21 31 41 51 GAGAGGGCCC GGACTAGGGG CGGCGGGCAC CGCAGGAGCT CCGCGCGGCT GCAGCGCGGG 60 CGGGAGCGGG GACGCGATGT CGCCGCCGCC GCCTCCTTGC GGGCCGGGGC TGCGCCTCCG 120 GGGCTGAGCC GCCGCCAGAG CCGACAGCCG AGCAGCCGCT GGGCGCTCCC GCGGCGCAGG 180 AGGATGGGCT GCGGCGGGAG CCGGGCGGAT GCCATCGAGC CCCGCTACTA CGAGAGCTGG 240 ACCCGGGAGA CAGAATCCAC CTGGCTCACC TACACCGACT CGGACGCGCC GCCCAGCGCC 300 GCCGCCCCGG ACAGCGGCCC CGAAGCGGGC GGCCTGCACT CGGGCATGCT GGAAGATGGA 360 CTGCCCTCCA ATGGTGTGCC CCGATCTACA GCCCCAGGTG GAATACCCAA CCCAGAGAAG 420 AAGACGAACT GTGAGACCCA GTGCCCAAAT CCCCAGAGCC TCAGCTCAGG CCCTCTGACC 480 CAGAAACAGA ATGGCCTTCA GACCACAGAG GCTAAAAGAG ATGCTAAGAG AATGCCTGCA 540 AAAGAAGTCA CCATTAATGT AACAGATAGC ATCCAACAGA TGGACAGAAG TCGAAGAATC 600 ACAAAGAACT GTGTCAACTA GCAGAGAGTC CAAGCAGAAG GGCAGATGGA CTTCTTCAGT 660 GTCCTTCACG GCACTGGATC CCATCAAAGA ACCTTGAAGA AGTGGCTGCC CCTTGCTGGA 720 CCTGAATTCT ACTGAGTCCC TGGCAAGACC GTCTTACCTG GCAGCAAACT GCTGCCTGAT 780 TTGTTGGGAC CTTCTGAGCC TTCTACTTAT CATGTAAATG TATTGGCACA GTGCTTACAT 840 ATGTTAATAA ACTGCAAATG TGCAGTTCAG TTTGTCTCTT TGCAACTCCT GTAATACGGT 900 CTGGTGTAAA AGTAGTGAGT TAAAGCTACA GGTCAGTTTA TGAAACAGAA AAGTAGGAAT 960 GCATTTTCTG GGTGAAAGAG TCACACCTTA GTGCTATAAC TCTCCTGCCC ATGATAGTGT 1020 ATTCTGTTTC AGGCAAGCTT ATTCTTTCCT TCCTTCATTT TAAATATTGT CATTACAAAT 1080 CTTACCAGGT TCACTTAAAA GCTGGCTTTC ATCCAACTCT AAACCCACAT ATTGAAAAAA 1140 TCAAGGTACA GGAAAACTCC TTGTTATCCT TGTTTCCTTA GCTTGGTATG AGACAGATCG 1200 GATCCAGTTT CCCATGCACC AACCCACTGC CCATGGCATG TCTTTGGGAG GTGTCTGTGA 1260 AGCAGTCATA CCTGCTCCTC ATCTGCCTGG AAAGTCCTCC TATTCCAGTG TCCATGTTGG 1320 CCTCCAGTCC TTAATGTCAC CATGCTTGTG GCCAATGCAT CCAAATAAGG ATACCCCTCA 1380 GGGCTCAGCT AGACATTGCA ATTTTGCATA GCTTTCCAGT TCCCTTTGCT TGTCTTCTTG 1440 ACTGTCTTCC CTCTCTACCG GGGTCACTTG CAATTGTTAA TCAAAGATTG AACACTGCGT 1500

AGGAGAGGGA GATGATCCAG AGACATGTGG CAGCAGGCAT GGCTTCCCCT TGGCCTCTCT 1560 GTACACTGCC CCAGGACTGT CATTTTGGCA TCTGCAAAGG AATCACTTTA GAAAGCCAGC 1620 ACCTGGTTGA TGTGTATTCA TACTGACATT AGATTGATGT GCACTGCATT AGAAATGAGG 1680 TAGCTGACAC AGAAAAAGGA TGTTTTGATA GGAATAATTT TCTAGTATGT CTTGAAACAT 1740 GTTCATCTGG AAGTATTTTC CTCCAAAGTA ATGTAGCATG ATTTTTCAAG GATTGTTAAC 1800 ATGCCTGGGA TTGGGAAAGA TAGGACTAAA GTTGTGCCAA ACTATATCAA TAAATTCCAT 1860 GTTTAGCAGA AATAGGCAGC CTATTGGTGT TATGTTTATG TAACATAGTC CAGAGAACTG 1920 ACATGCAGGT CAAAAGTCAG ATACGCAACC TCCTTATCTG CTAACTCTGT TATTCTTCAA 1980 ACACAAGTGG GTAGTGTCAT TTTTCCTTCC TTCCTTCCAT TGGCAGATTG TATATTTATT 2040 CACAAAACAT TAAATGTCCA TCCTGTGCCA GGTACTATGC AGATGTTGAG GGATTTGGGG 2100 TCTGGTTAGT CGTGACTATC TATCCTGAAT CTAACAGTGA CTTCATAACT AGGAGACTGA 2160 ATTAGACCCT TAAGGTATAG TGTGTGTTGC AAATCACTCT GCAATGGAAA CTTTTATATT 2220 CAGGGTAGGT TTGTGTCTTA AACTAGGTGT TCTAATCAAT GTACAAGACT TTACCATACA 2280 CGCAACTATA GTTTTTCTAA ACCTTCATCA TTTTGTGATT CTTTGAGAAA GGGCTTTTAG 2340 GAACTTTATG TTCTAAAAAA TGTTTTTAAC AATAATAAGA TAAAAGAAAA ACCTGTGATT 2400 CATATGTCCC CACTGGCATT ACTCAGCAGG AGCCCCCAGC TGCCAAAGGT TGGCAGTGAT 2460 CCTGCAAGTT CAAGGGCTCT TTCTCCCTGG GGATGTGCTT TGTGGCTTCT CTTTACAGCT 2520 TTGTTTCTGC ATCAGTTCAC TGCTGCATGT TGTTTGGAAT TTATCACCTT AAGAAAGTGT 2580 CTCTGTTTTA TATAGAAACA CTTTCTCACT TACAGGGGAG AAGGAAATGC AGGGCACATG 2640 ATCTGGCCCT CCCCAGAACA ATCTGGATTT CACGGAGACA GCAACCAGAA GTTAAACCAT 2700 GTGACTAAAA ATGCATCTGG CTACTTTTTC ATGTATGTAT GAGACAGAAA CTAATCCTTA 2760 CTATCCTATT AGGATACCAC TTTTCATTGC AAAGTTTGTG TCAATAAAGT CATTAATTTT 2820 AAACAT 2826 Seq ID NO : 136 DNA Sequence Nucleic Acid Accession # : XM040550. 1 Coding sequence : 82.. 4158 1 11 21 31 41 51 CCTTGGTTTC CGTTGCAGAT TCCCACAACT CCATGCTGTG TGCTGCAGGC TGGTCCTGAA 60 CCCAGATCTC TGGCTGAGAG GATGGGGGCA GATGGGGAAA CAGTGGTTCT GAAGAACATG 120 CTCATTGGCA TCAACCTGAT CCTTCTGGGC TCCATGATCA AGCCTTCAGA GTGTCAGCTG 180 GAGGTCACCA CAGAAAGGGT CCAGAGACAG TCAGTGGAGG AGGAGGGAGG CATTGCCAAC 240 TACAACACAT CCAGCAAAGA GCAGCCTGTG GTCTTCAACC ACGTGTACAA CATTAACGTG 300 CCCTTGGACA ACCTCTGCTC CTCAGGGCTA GAGGCCTCTG CTGAGCAGGA GGTGAGTGCA 360 GAAGACGAGA CTCTGGCAGA GTACATGGGC CAGACCTCAG ACCACGAGAG CCAGGTCACC 420 TTTACACACA GGATCAACTT CCCCAAAAAG GCCTGTCCAT GTGCCAGTTC AGCCCAGGTG 480 CTGCAGGAGC TGCTGAGCCG GATCGAGATG CTGGAGAGGG AGGTGTCGGT GCTGCGAGAC 540 CAGTGCAACG CCAACTGCTG CCAAGAAAGT GCTGCCACAG GACAACTGGA CTATATCCCT 600 CACTGCAGTG GCCACGGCAA CTTTAGCTTT GAGTCCTGTG GCTGCATCTG CAACGAAGGC 660 TGGTTTGGCA AGAATTGCTC GGAGCCCTAC TGCCCGCTGG GTTGCTCCAG CCGGGGGGTG 720 TGTGTGGATG GCCAGTGCAT CTGTGACAGC GAGTACAGCG GGGATGACTG TTCCGAACTC 780 CGGTGCCCAA CAGACTGCAG CTCCCGGGGG CTCTGCGTGG ACGGGGAGTG TGTCTGTGAA 840 GAGCCCTACA CTGGCGAGGA CTGCAGGGAA CTGAGGTGCC CTGGGGACTG TTCGGGGAAG 900 GGGAGATGTG CCAACGGTAC CTGTTTATGC GAGGAGGGCT ACGTTGGTGA GGACTGCGGC 960 CAGCGGCAGT GTCTGAATGC CTGCAGTGGG CGAGGACAAT GTGAGGAGGG GCTCTGCGTC 1020 TGTGAAGAGG GCTACCAGGG CCCTGACTGC TCAGCAGTTG CCCCTCCAGA GGACTTGCGA 1080 GTGGCTGGTA TCAGCGACAG GTCCATTGAG CTGGAATGGG ACGGGCCGAT GGCAGTGACG 1140 GAATATGTGA TCTCTTACCA GCCGACGGCC CTGGGGGGCC TCCAGCTCCA GCAGCGGGTG 1200 CCTGGAGATT GGAGTGGTGT CACCATCACG GAGCTGGAGC CAGGTCTCAC CTACAACATC 1260 AGCGTCTACG CTGTCATTAG CAACATCCTC AGCCTTCCCA TCACTGCCAA GGTGGCCACC 1320 CATCTCTCCA CTCCTCAAGG GCTACAATTT AAGACGATCA CAGAGACCAC CGTGGAGGTG 1380 CAGTGGGAGC CCTTCTCATT TTCCTTCGAT GGGTGGGAAA TCAGCTTCAT TCCAAAGAAC 1440 AATGAAGGGG GAGTGATTGC TCAGGTCCCC AGCGATGTTA CGTCCTTTAA CCAGACAGGA 1500 CTAAAGCCTG GGGAGGAATA CATTGTCAAT GTGGTGGCTC TGAAAGAACA GGCCCGCAGC 1560 CCCCCTACCT CGGCCAGCGT CTCCACAGTC ATTGACGGCC CCACGCAGAT CCTGGTTCGC 1620 GATGTCTCGG ACACTGTGGC TTTTGTGGAG TGGATTCCCC CTCGAGCCAA AGTCGATTTC 1680 ATTCTTTTGA AATATGGCCT GGTGGGCGGG GAAGGTGGGA GGACCACCTT CCGGCTGCAG 1740 CCTCCCCTGA GCCAATACTC AGTGCAGGCC CTGCGGCCTG GCTCCCGATA CGAGGTGTCA 1800 GTCAGTGCCG TCCGAGGGAC CAACGAGAGC GATTCTGCCA CCACTCAGTT CACAACAGAG 1860 ATCGATGCCC CCAAGAACTT GCGAGTTGGT TCTCGCACAG CAACCAGCCT TGACCTCGAG 1920 TGGGATAACA GTGAAGCCGA AGTTCAGGAG TACAAGGTTG TGTACAGCAC CCTGGCGGGT 1980 GAGCAATATC ATGAGGTACT GGTCCCCAGG GGCATTGGTC CAACCACCAG GGCCACCCTG 2040 ACAGATCTGG TACCTGGCAC TGAGTATGGA GTTGGAATAT CTGCCGTCAT GAACTCACAG 2100 CAAAGCGTGC CAGCCACCAT GAATGCCAGG ACTGAACTTG ACAGTCCCCG AGACCTCATG 2160 GTGACAGCCT CCTCGGAGAC CTCCATCTCC CTCATCTGGA CCAAGGCCAG TGGCCCCATT 2220 GACCACTACC GAATTACCTT TACCCCATCC TCTGGGATTG CCTCAGAAGT CACCGTACCC 2280 AAGGACAGGA CCTCATACAC ACTAACAGAT CTAGAGCCTG GGGCAGAGTA CATCATTTCC 2340 GTCACTGCTG AGAGGGGTCG GCAGCAGAGC TTGGAGTCCA CTGTGGATGC TTTCACAGGC 2400 TTCCGTCCCA TCTCTCATCT GCACTTTTCT CATGTGACCT CCTCCAGTGT GAACATCACT 2460 TGGAGTGATC CATCTCCCCC AGCAGACAGA CTCATTCTTA ACTACAGCCC CAGGGATGAG 2520 GAGGAAGAGA TGATGGAGGT CTCCCTGGAT GCCACCAAGA GGCATGCTGT CCTGATGGGC 2580 CTGCAACCAG CCACAGAGTA TATTGTGAAC CTTGTGGCTG TCCATGGCAC AGTGACCTCT 2640 GAGCCCATTG TGGGCTCCAT CACCACAGGA ATTGATCCCC CAAAAGACAT CACAATTAGC 2700 AATGTGACCA AGGACTCAGT GATGGTCTCC TGGAGCCCTC CTGTTGCATC TTTCGATTAC 2760 TACCGAGTAT CATATCGACC CACCCAAGTG GGACGACTAG ACAGCTCAGT GGTGCCCAAC 2820 ACTGTGACAG AATTCACCAT CACCAGACTG AACCCAGCTA CCGAATACGA AATCAGCCTC 2880 AACAGCGTGC GGGGCAGGGA GGAAAGCGAG CGCATCTGTA CTCTTGTGCA CACAGCCATG 2940 GACAACCCTG TGGATCTGAT TGCTACCAAT ATCACTCCAA CAGAAGCCCT GCTGCAGTGG 3000 AAGGCACCAG TGGGTGAGGT GGAGAACTAC GTCATTGTTC TTACACACTT TGCAGTCGCT 3060 GGAGAGACCA TCCTTGTTGA CGGAGTCAGT GAGGAATTTC GGCTTGTTGA CCTGCTTCCT 3120 AGCACCCACT ATACTGCCAC CATGTATGCC ACCAATGGAC CTCTCACCAG TGGCACCATC 3180 AGCACCAACT TTTCTACTCT CCTGGACCCT CCGGCAAACC TGACAGCCAG TGAAGTCACC 3240 AGACAAAGTG CCCTGATCTC CTGGCAGCCT CCCAGGGCAG AGATTGAAAA TTATGTCTTG 3300

ACCTACAAAT CCACCGATGG AAGCCGCAAG GAGCTGATTG TGGATGCAGA AGACACCTGG 3360 ATTCGACTGG AGGGCCTGTT GGAGAACACA GACTACACGG TGCTCCTGCA GGCAGCACAG 3420 GACACCACGT GGAGCAGCAT CACCTCCACC GCTTTCACCA CAGGAGGCCG GGTGTTCCCT 3480 CATCCCCAAG ACTGTGCCCA GCATTTGATG AATGGAGACA CTTTGAGTGG GGTTTACCCC 3540 ATCTTCCTCA ATGGGGAGCT GAGCCAGAAA TTACAAGTGT ACTGTGATAT GACCACCGAC 3600 GGGGGCGGCT GGATTGTATT CCAGAGGCGG CAGAATGGCC AAACTGATTT TTTCCGGAAA 3660 TGGGCTGATT ACCGTGTTGG CTTCGGGAAC GTGGAGGATG AGTTCTGGCT GGGGCTGGAC 3720 AATATACACA GGATCACATC CCAGGGCCGC TATGAGCTGC GCGTGGACAT GCGGGATGGC 3780 CAAGAGGCCG CCTTCGCCTC CTACGACAGG TTCTCTGTCG AGGACAGCAG AAACCTGTAC 3840 AAACTCCGCA TAGGAAGCTA CAACGGCACT GCGGGGGACT CCCTCAGCTA TCATCAAGGA 3900 CGCCCTTTCT CCACAGAGGA TAGAGACAAT GATGTTGCAG TGACTAACTG TGCCATGTCG 3960 TACAAGGGAG CATGGTGGTA TAAGAACTGC CACCGGACCA ACCTCAATGG GAAGTACGGG 4020 GAGTCCAGGC ACAGTCAGGG CATCAACTGG TACCATTGGA AAGGCCATGA GTTCTCCATC 4080 CCCTTTGTGG AAATGAAGAT GCGCCCCTAC AACCACCGTC TCATGGCAGG GAGAAAACGG 4140 CAGTCCTTAC AGTTCTGAGC AGTGGGCGGC TGCAAGCCAA CCAATATTTT CTGTCATTTG 4200 TTTGTATTTT ATAATATGAA ACAAGGGGGG AGGGTAATAG CAATGTGTTT TGCAACATAT 4260 TAAGAGTATG TGAAGGAAGC AGGGATGTCG CAGGAATCCG CTGGCTAACA TCTGCTCTTG 4320 GTTTCTGCTG CCCTGGAGCC TGACCCTCAG TCTCCATTCT CCCTCCTACC CAGGCCTCCT 4380 CAACCTTCAC CTCCTTTCCC ACCAAGGAGG AGAAGTAGGA AGTTTTCTTA AAGGGCCAAT 4440 TCAAAGCCAA GTCGTGGGGT GCAGATTGTT ATGGTGACAG GCACACACAT TTTTCTACCC 4500 TTCTTCTGAG ATGTCCTCTG CCTTCCAGGT ATTTGTGATT TTGTCACAGC CTGACATGGC 4560 CAGGTTCTCA CACTGGCCCA GAGAAAAGAG CCTCAGCAAG AGAGTTTTGC CAACAATTCC 4620 CCTTAAAAGG AAACAGATCA ACTACACCGC ATCCCAACAA CCCAGGTTCT TTTCCTTCCT 4680 TCCTTCCTTC CTCCCTTCCT TCTTTCCTGC CTTCCC 4716 Seq ID NO : 137 DNA Sequence Nucleic Acid Accession # : NM 005883. 1 Coding sequence : 1714.. 8625 1 11 21 31 41 51 GGGTTTGGGG AGCAGGAGGC AGACATGTGT TGCTTTGCAC GTCATCTGGT C « TCCACCT 60 GGCTGGGCAT GGGATGGTGA CCTCAGCTGG AACATGGGGC TCGAGCCAGA CCTCAGGGTC 120 TCCCTGCGTG TAGCCCCCAA CCCCAAGCCT GATCCCCACC GGAGACCTGA ACAGCCTTGG 180 ACATCATCGG ATCAGGGTGG GAGGTGCCAG CCTCTGCCAC CTGACTTCCA GTCCCTGTGC 240 CCCTCCCACC CTGCCCTTGG GCACTCCTGC CCTGCAGGTT CCTCAGAGGG GCAACCCAAA 300 GCCAGAGAGG GGCGGGTCTT GTCGGGCCTC CAGCCTGGAC TTCCCAGCCC CTCTGGGGCA 360 GCATCTGGGT GCCAGACCTC GGTTCCTAGG GCCTCGTTTC TCCCTCTGGG AACAGCCAAA 420 TGGTGGTCCC TGAGACTCAG GACAGACCAA GAAGAAGCCG GATGACATGG CAAGCCACAC 480 ACTGCGTCCC CTGAGCAGGA CGGGACAGCC CGACTCCATC CTCCCACCTG CGACTGAGCC 540 CCCACCCCTA CTCCTGTCCC AGCCGTGCCC CTGGTGACAT TTGGGTGGGA GGGGAGGGGA 600 TGAGGGGGCA CCTGGGGGTC AGAGAACAAA TGACGGGTGA ATACATGTGT GTGGCCAGGT 660 GGAGGAGGGA GGGGAGGAGC AGGTGGGCTG GACAGGGCCG GTGTGAGGAA GGGGCTCAGG 720 CTGGCAGGGG GAGGTGGCAA GAGGGATGGG CTGCCATTGG TGGTCTGAGA CAAAGGCGGA 780 GGGAGGAGGC GAGCGCTGAT GGGAAAGGAA CAAAGAGGGA AGGGGGGCGT GAAGGGGGTT 840 CCGGCGGGAG GGCCGAGCCG AGGGAGGAGG CGCCGGCCAG CTGGACAGAG GGAGGAGGCC 900 AGGCCAGAGC CAGAAGACGG CCAGAGGCAC AAAGAAGCCA GCGCGCTGGC GGAGTCAAGG 960 GATGGGGCAG AGACTGCCGG GGCCAGCAGG GACCAGCTGA AGGCTGCGCA GGGGGTGCGG 1020 GCCACACAGG TAGCCACCCT GAGCTCAGCC ACCGATGGAG GGTCGTGGGG CTGCTGCGGT 1080 GATGGCGGTG GGCTTGGGTC CATCTGTCCT GCCGTTTCTG CACAGCTTAG GTGTCACCCA 1140 CTGGCCTTCG TGGTGTTTTC ATTGTCCATC GGCAGGGACA GCTGGTGGTC TGTCTGCCCC 1200 GCCTGTCTGG CTGTCAGCCT CTGGGCAGGC TTGCTTTTAT GGGGGAGGGT CCTGTCTGTC 1260 TGTCTGTCGC CCTCTCTGGC TGTGAGCCTG GGGGTGCTGG GCTGGCCAGT CGGCTTGCTG 1320 GGTTAGGCTG TCCCAGCTGT CTGAGTGTTT GTCCGGCTGT CAGGATGTGT CCTGGGGGCT 1380 GGGAAGGAGA GGCCGACCCA TNGTCTGTCG GTCGACTGGT CAGTTGGACG TTCAGCTGTC 1440 TGTACGTCTG TCTGCTGGCC CATCTGTCTC CCCTTGGGGC CACCTCTCAC TCCACCTGCC 1500 CCTCTGCGCC CCGGATTGCC TGGCCAGCAC CACGTGGGCC TGTACTTGTC CACACCAGTG 1560 ACTCCTGCCT GAGACCCCCC CCCAACCCAG GATCAGGCAG GACGGCTGGG GCTTAGGTCA 1620 GGGGCCGTCT GTCCGGAAGG CATCACCGCG CCCTCCCCAG ACCATCAGCT GAACCCTCTG 1680 ACCCTGTGAT CCCAGACGCT GCAGGAGCTG AAGATGGCGA GCTCCGTGGC GCCCTACGAG 1740 CAGCTGGTGA GGCAGGTGGA GGCCTTGAAG GCTGAGAACA GCCACCTGAG GCAGGAGCTA 1800 AGGGACAACT CCAGCCACCT GTCCAAGCTG GAGACAGAGA CGTCGGGCAT GAAGGAGGTC 1860 CTGAAGCACC TACAGGGAAA ACTGGAGCAG GAGGCCCGAG TGCTGGTGTC CTCGGGGCAG 1920 ACGGAGGTGC TGGAGCAGCT GAAGGCCCTA CAGATGGACA TCACCAGCCT GTACAACCTC 1980 AAGTTCCAGC CGCCCACCCT GGGCCCGGAG CCTGCCGCCC GGACCCCCGA GGGCAGCCCA 2040 GTACACGGCT CCGGGCCCTC CAAGGACAGC TTTGGGGAGC TGAGCCGGGC CACCATCCGG 2100 CTGCTGGAGG AACTGGACCG GGAACGGTGT TTCCTGCTGA ATGAGATTGA GAAGGAGGAG 2160 AAGGAGAAGC TCTGGTACTA CTCTCAGCTG CAGGGCCTGT CCAAGCGCCT GGACGAGCTG 2220 CCGCACGTGG AGACGCAGTT CTCGATGCAG ATGGACCTGA TCCGGCAGCA GCTTGAGTTC 2280 GAGGCCCAGC ACATCCGCTC GCTGATGGAG GAGCGCTTCG GCACCTCGGA CGAGATGGTG 2340 CAGCGGGCAC AGATCCGCGC CTCGCGCCTG GAGCAGATTG ACAAGGAGCT GCTGGAGGCG 2400 CAGGACCGAG TGCAGCAGAC GGAGCCCCAG GCCTTGCTGG CGGTGAAGTC GGTGCCGGTG 2460 GACGAGGACC CCGAGACAGA GGTCCCCACA CACCCTGAGG ATGGCACCCC TCAGCCGGGC 2520 AACAGCAAGG TGGAGGTGGT CTTCTGGCTG TTGTCCATGT TGGCGACGCG CGACCAGGAG 2580 GATACAGCGC GCACGCTGCT GGCCATGTCC AGCTCGCCCG AGAGCTGCGT GGCCATGCGC 2640 CGCTCGGGCT GTCTGCCTCT GCTGCTGCAA ATCCTCCACG GCACCGAGGC CGCGGCCGGG 2700 GGTCGCGCCG GGGCCCCAGG GGCACCGGGC GCCAAGGACG CACGCATGCG CGCCAACGCG 2760 GCGCTGCACA ACATCGTCTT CTCGCAGCCG GACCAGGGCC TGGCGCGCAA GGAGATGCGC 2820 GTCCTGCACG TGCTGGAGCA GATCCGGGCC TACTGCGAGA CCTGCTGGGA CTGGCTGCAG 2880 GCCCGAGACG GCGGGCCCGA GGGAGGTGGC GCCGGCAGCG CCCCGATCCC CATCGAGCCG 2940 CAGATCTGCC AGGCCACCTG TGCTGTTATG AAGCTGTCCT TTGATGAGGA GTACCGCCGT 3000 GCCATGAACG AGCTAGGTGG GCTGCAGGCC GTGGCAGAGC TGCTGCAGGT TGACTATGAG 3060 ATGCACAAGA TGACCCGGGA CCCGCTGAAC CTGGCGCTGC GCCGCTACGC GGGCATGACC 3120 CTCACCAACC TCACCTTTGG GGACGTTGCC AACAAGGCCA CCCTGTGTGC GCGCCGCGGC 3180 TGCATGGAGG CCATCGTGGC CCAGCTGGCC TCCGACAGTG AGGAGCTCCA CCAGGTGGTG 3240

TCCAGCATCC TTCGGAACTT GTCCTGGAGG GCCGACATCA ACAGCAAGAA GGTGCTGAGG 3300 GAGGCGGGCA GCGTGACTGC CCTGGTGCAG TGTGTCCTGC GGGCCACCAA GGAGTCCACC 3360 CTGAAGAGCG TGCTGAGCGC CCTGTGGAAT CTGTCTGCAC ACAGCACAGA GAACAAGGCG 3420 GCCATCTGCC AGGTGGATGG CGCCCTGGGC TTCCTGGTGA GCACCCTGAC CTACAAGTGT 3480 CAGAGCAACT CGCTGGCCAT CATCGAGAGC GGCGGCGGCA TCCTCCGCAA TGTGTCCAGC 3540 CTCGTCGCCA CCCGTGAGGA CTACAGGCAG GTGCTCCGGG ATCACAACTG TCTGCAGACG 3600 CTGCTGCAGC ATCTGACTTC GCACAGCCTG ACCATCGTGA GCAACGCGTG CGGCACGCTC 3660 TGGAACCTGT CGGCCCGCAG CGCCCGTGAC CAGGAGCTGC TGTGGGACCT GGGCGCCGTG 3720 GGCATGCTGC GTAATCTGGT GCACTCCAAG CACAAGATGA TCGCCATGGG CAGCGCCGCC 3780 GCCCTGCGCA ACCTGCTGGC CCATCGGCCC GCCAAGCACC AGGCGGCCGC CACCGCCGTG 3840 TCCCCAGGCA GCTGCGTGCC CAGCCTGTAC GTGCGCAAGC AGCGGGCGCT GGAGGCCGAG 3900 CTGGACGCAC GGCACCTCGC GCAGGCGCTG GAGCACCTGG AGAAGCAGGG CCCGCCGGCA 3960 GCCGAGGCCG CCACTAAGAA GCCGCTGCCG CCCCTGCGAC ACCTGGACGG CCTGGCCCAA 4020 GACTATGCTT CCGATTCGGG CTGCTTTGAC GACGACGATG CACCGTCATC CCTGGCTGCG 4080 GCCGCGGCCA CCGGGGAGCC AGCCAGCCCT GCCGCGCTGT CCCTCTTCCT GGGCAGCCCC 4140 TTCCTGCAGG GGCAGGCGCT GGCTCGCACC CCGCCCACCC GCCGAGGCGG CAAGGAGGCA 4200 GAGAAGGACA CCAGTGGGGA GGCAGCCGTG GCGGCCAAGG CCAAGGCCAA GCTGGCGCTT 4260 GCAGTGGCGC GCATCGACCA GCTGGTGGAG GACATCTCCG CCCTGCACAC CTCGTCCGAC 4320 GATAGCTTCA GCCTCAGCTC TGGAGACCCG GGACAGGAGG CGCCACGGGA GGGCCGCGCC 4380 CAGTCCTGCT CGCCATGCCG CGGCCCGGAG GGCGGGCGGC GAGAGGCAGG AAGCCGGGCG 4440 CACCCGCTGC TGCGGCTCAA GGCGGCCCAC GCCAGCCTCT CCAACGACAG CCTCAACAGC 4500 GGCAGTGCCA GCGACGGGTA CTGCCCACGC GAACATATGC TGCCCTGCCC GCTGGCCGCA 4560 CTGGCTTCGC GCCGCGAGGA CCCCAGGTGT GGGCAGCCTC GGCCCAGCCG GCTTGACCTT 4620 GACCTGCCCG GCTGCCAGGC CGAGCCCCCG GCCCGCGAGG CCACCTCCGC CGACGCCCGC 4680 GTGCGCACCA TCAAGCTGTC GCCTACCTAT CAGCACGTGC CACTGCTTGA GGGTGCCTCA 4740 AGGGCGGGTG CAGAGCCCCT CGCGGGGCCT GGAATCTCTC CAGGGGCCCG GAAGCAGGCC 4800 TGGCTGCCGG CAGACCACCT GAGCAAGGTT CCCGAGAAGC TGGCGGCTGC CCCGCTGTCT 4860 GTGGCCAGCA AGGCACTGCA GAAACTGGCG GCGCAAGAGG GGCCACTCTC GCTGTCCCGA 4920 TGCAGCTCCC TTTCCTCGCT GTCCTCGGCC GGCCGCCCAG GCCCCAGCGA GGGTGGTGAC 4980 CTGGATGACA GTGACTCCTC CCTGGAGGGG CTGGAGGAGG CCGGCCCCAG CGAGGCTGAG 5040 CTGGACAGCA CGTGGCGGGC GCCCGGGGCC ACCTCGCTGC CCGTAGCCAT TCCGGCTCCC 5100 CGGCGTAACC GAGGCCGGGG CCTGGGGGTG GAAGACGCCA CGCCGTCCAG CTCGTCGGAG 5160 AACTACGTGC AGGAGACACC GCTTGTGCTG AGCCGCTGCA GCTCTGTGAG CTCGCTGGGC 5220 AGCTTCGAGA GCCCGTCCAT CGCCAGCTCC ATCCCCAGTG AACCTTGCAG CGGGCAGGGC 5280 AGCGGCACCA TCAGCCCTAG CGAGCTGCCC GACAGCCCCG GACAGACCAT GCCTCCCAGC 5340 CGGAGCAAGA CGCCACCGCT GGCGCCCGCG CCACAGGGTC CCCCCGAGGC CACCCAGTTC 5400 AGCCTGCAGT GGGAGAGCTA CGTGAAGCGC TTCCTGGACA TCGCCGACTG CCGGGAGCGC 5460 TGCCGGCTGC CATCTGAGCT GGACGCAGGC AGCGTGCGCT TTACCGTGGA GAAGCCAGAC 5520 GAGAACTTCT CGTGCGCCTC CAGCCTCAGC GCGCTGGCCT TGCACGAGCA CTACGTGCAG 5580 CAGGACGTGG AGCTGCGGCT GCTGCCCTCG GCCTGCCCCG AGCGCGGCGG GGGCGCCGGG 5640 GGCGCCGGCC TCCATTTTGC AGGGCACCGG CGGCGGGAGG AGGGGCCGGC GCCCACGGGT 5700 TCTCGCCCTC GCGGCGCCGC GGACCAGGAG CTGGAACTGC TGCGGGAGTG CCTGGGAGCC 5760 GCCGTGCCTG CCCGGCTGCG CAAGGTGGCC TCCGCGCTGG TGCCAGGTCG CCGCGCACTC 5820 CCCGTGCCCG TCTACATGTT GGTGCCCGCC CCGGCCCCGG CCCAGGAGGA CGACTCCTGC 5880 ACTGACTCCG CGGAGGGCAC GCCGGTCAAC TTCTCTAGCG CCGCCTCGCT CAGCGACGAG 5940 ACGCTGCAGG GACCCCCCAG GGACCAGCCC GGGGGACCAG CGGGCAGGCA AAGACCCACC 6000 GGCCGCCCCA CCTCTGCCAG ACAGGCCATG GGGCACCGGC ACAAGGCGGG AGGCGCCGGC 6060 CGCAGCGCGG AGCAGTCTCG GGGCGCGGGC AAGAACCGAG CAGGGCTGGA GCTGCCCCTG 6120 GGCCGGCCCC CGAGCGCCCC CGCAGACAAG GACGGCTCAA AGCCCGGCCG GACCCGCGGG 6180 GACGGGGCGC TCCAGTCGCT GTGCCTCACG ACGCCCACTG AGGAGGCCGT GTACTGCTTC 6240 TACGGCAACG ACTCGGACGA GGAGCCCCCG GCGGCCGCGC CCACGCCAAC CCACCGGCGC 6300 ACATCGGCCA TCCCTCGCGC TTTTACGCGG GAGCGTCCGC AGGGCCGGAA GGAGGCCCCT 6360 GCCCCGTCCA AGGCTGCACC AGCTGCCCCG CCGCCCGCCC GGACCCAGCC CAGCCTCATT 6420 GCTGACGAGA CCCCGCCCTG CTACTCCCTG AGCTCCTCCG CCAGCTCCCT CAGCGAGCCC 6480 GAGCCCTCGG AGCCGCCGGC CGTCCATCCA CGAGGCCGGG AGCCCGCGGT CACCAAGGAC 6540 CCGGGCCCAG GAGGCGGACG CGACAGCTCG CCCAGCCCGC GGGCCGCGGA GGAGCTTCTG 6600 CAGCGGTGCA TCAGCTCGGC CCTGCCCAGG CGCCGGCCCC CCGTGTCTGG CCTGCGGCGC 6660 CGCAAGCCCC GAGCCACCCG GCTGGATGAG CGGCCCGCAG AGGGGTCCCG GGAACGCGGC 6720 GAGGAGGCAG CGGGCTCGGA CCGGGCCTCC GACCTGGATA GCGTGGAGTG GCGCGCCATC 6780 CAGGAGGGCG CCAATTCAAT TGTCACGTGG CTGCACCAGG CAGCAGCTGC CACGCGGGAG 6840 GCCTCGTCCG AGTCCGACTC CATCCTGTCC TTCGTATCCG GGCTGTCAGT GGGATCCACC 6900 CTACAGCCCC CCAAGCACAG GAAGGGACGA CAGGCGGAGG GAGAAATGGG CAGTGCCCGG 6960 CGGCCAGAGA AAAGGGGCGC AGCCTCAGTC AAGACCAGCG GGAGCCCCCG TTCCCCTGCA 7020 GGCCCCGAGA AGCCACGTGG CACACAGAAG ACCACGCCCG GGGTGCCAGC TGTGCTCCGG 7080 GGACGAACAG TGATCTACGT CCCCAGCCCG GCACCCCGTG CCCAGCCCAA AGGGACCCCC 7140 GGCCCCCGCG CCACACCGCG GAAGGTGGCG CCCCCTTGCC TGGCACAGCC CGCGGCTCCA 7200 GCCAAAGTCC CGAGCCCCGG GCAGCAGCGG TCGCGGAGCC TACACCGGCC TGCCAAGACC 7260 TCGGAGCTGG CGACGCTGAG CCAGCCCCCC AGAAGCGCCA CACCGCCCGC CCGCCTCGCC 7320 AAGACCCCCT CCTCCAGCTC CTCCCAGACC TCGCCCGCCT CCCAGCCCCT GCCCAGAAAG 7380 CGCCCCCCGG TCACCCAGGC TGCTGGGGCC CTGCCCGGCC CCGGAGCCTC CCCGGTGCCC 7440 AAAACGCCGG CGCGCACCCT TCTGGCGAAG CAGCACAAGA CGCAGAGATC GCCCGTGCGG 7500 ATCCCGTTCA TGCAGAGGCC GGCCCGGCGT GGGCCGCCAC CGCTGGCTCG GGCAGTCCCG 7560 GAGCCGGGCC CCAGGGGCCG GGCGGGGACC GAGGCGGGCC CGGGGGCGCG CGGGGGCCGC 7620 CTGGGCCTGG TGCGTGTGGC CTCAGCCCTC TCCAGCGGCA GCGAGTCCTC CGACCGCTCG 7680 GGCTTCCGGC GACAGCTAAC CTTCATCAAG GAGTCGCCGG GCTTGCGGCG CCGCCGCTCC 7740 GAGCTGTCCT CGGCCGAGTC CGCGGCCTCT GCCCCCCAGG GCGCCTCGCC CCGCCGCGGC 7800 CGGCCCGCGC TGCCCGCCGT CTTCCTCTGC TCCTCGCGCT GCGAAGAGCT CCGAGCGGCA 7860 CCCCGGCAGG GCCCGGCCCC GGCCCGGCAG CGGCCCCCCG CGGCCCGACC CAGCCCTGGC 7920 GAGCGCCCTG CCCGGCGCAC CACCTCCGAG AGCCCGTCCC GCCTGCCTGT GCGCGCGCCC 7980 GCCGCCCGGC CGGAGACTGT CAAGCGCTAC GCGTCGCTGC CGCACATCAG CGTGGCCCGC 8040 AGGCCCGACG GCGCCGTCCC CGCGGCCCCT GCCTCAGCCG ACGCCGCGCG CCGCAGCAGC 8100 GACGGGGAGC CCCGGCCGCT CCCCAGGGTG GCCGCGCCGG GCACGACCTG GCGGCGCATC 8160 CGAGATGAGG ACGTGCCCCA CATCCTGCGC AGCACGCTTC CCGCCACGGC CCTGCCACTG 8220 CGGGGCTCCA CGCCCGAGGA CGCCCCGGCC GGGCCCCCGC CGCGCAAGAC CAGCGACGCC 8280

GTGGTCCAGA CCGAGGAGGT CGCCGCCCCC AAGACCAACT CCAGCACGTC CCCGAGCCTG 8340 GAGACCAGGG AGCCCCCCGG GGCCCCCGCC GGCGGCCAGC TCTCCCTCCT CGGCAGCGAC 8400 GTGGACGGTC CCAGCCTCGC CAAGGCTCCC ATCTCCGCAC CCTTCGTGCA CGAGGGCCTG 8460 GGGGTCGCCG TGGGGGGCTT CCCCGCCAGC CGGCACGGCT CCCCCAGCCG CTCGGCCCGA 8520 GTACCCCCCT TCAACTATGT GCCCAGCCCC ATGGTGGTCG CAGCCACCAC CGACTCGGCC 8580 GCGGAGAAAG CCCCGGCCAC TGCCTCCGCC ACCCTCCTGG AATAGTGGCC TAGGCCGGCC 8640 TTCTGGAACG TTCTCTCCCG GCCCTGCGGC GCGGTCTGGC TGCCCCATGG GCCTGCGCTG 8700 TAGACGTCCC CCATAGGTCG CCCCAGGGCC TCTGCCCACC CGAGCCCCAC CACTCTCAGA 8760 ACCCCCGCCC AGCGCACGGC GACCTCGCGC CTCACCGGAA GACCTTGCCT CTGTGCCGCG 8820 GAGGTCCAGG AGGAAACGGG GCGGCCGCTA GGCCTCAAGT CCCGACCGTG GAGCGCTGGC 8880 AAGGGCGTCC TGGCCCAGCC CTGAGCGCGC GGCCCTTCCC CTGTCGGAAG CCGTTGCTTG 8940 ACCCCGGGCG AGGGAGGCGG TAGCCTCCGG GTCCGGGTCT GGGTCTGGGT CCGCTGCTTC 9000 GCAGGGACAG CGCTGGGGAG GTGACGGCGC CCGCCGCAGG TGGGGCGAGG CTGGGGGAGG 9060 GCGGCGCCGC GGCGGGCCTG CCAGCTGGGG GCCTTTGCGG CGCGCAGGGG CGAAGCCTGT 9120 AATCACTGCA GCCGCCGGTA ATTCGCTAAT GAGGGCTTTG CAGGGATTGT TTTCATTCTC 9180 AGCCCCAGCT GTGGGAGTGC GGGTGGGGGT GTGGCCGAGC CCCGGCAGGA AGCCCCGCCC 9240 AGACGGTGTT CAGGGAACCC GGAGCCCAAG CGCTCCGGCG GAGCCCAAAA GGGTGGGGGT 9300 GGGAGGGGCA GAGGCCAACG GATCCCCCTG CCTGTCGCAC CCCTTGGCGG GAGACGGGAA 9360 GGCAGCGGGC TGCGTACGAT GGGACCTGGT GCAGACGCCG GGCCGGCTGA CATTTGGACC 9420 CCATCCCAGA GGAGATGCTG GCTACCAGCT GGGGCGACCC CAAGGGTCGC TGGAGTCAGT 9480 ATCGGCCCGG CGCAGCCGCG GCGGGCGAGG CCAATGGAAA GGAGACTGAG GGGAGTCCCG 9540 GCAGTGAGCC CGAGGCCCTG GGACCTGGAG CCCGCGCTGG CCTCTCCCCA GCGGAGCCTG 9600 CACGTTACGG AGACCATCAC ATGTGGGCGT GGTCAGTGCC CAGGACCGCA CCGCTGCTCA 9660 TCTTGTCCCT TTTCAATTCC CTTCTGGTTC ATGATGCATA AAGCGCTAGG CCCTAGAACT 9720 CCAGAAACAG CACAGCTGGG GCGGGGACCC AGCCTTGCCC TCCACCCGAG GCTCTGGGAC 9780 AAGGCGGGAG GTTCGGGGGC CTTCCGGCAG GTGAACGCAG GGCTGGAGAG TATTTGGTGC 9840 CAGATGAGGT GAAAGCTTAT AGAAGGGCCT GAGGGGCTCG GCTGCCTCAT CCCCTGGCGG 9900 GGGAGGCTGG GAGCTGGGCC TCCTGCGTGG GGTGGGACTC GCAGGGGCCG GGTCTCCGTG 9960 ACTGGGGCAA CGCCTCGTCC TGCAGAGGGA GCCGACAACC TCTTTTCTGC AGAAAAGCTC 10020 CAGCAGGCGC TGCCTTCACC CACGGATCTG CCCAGGCTGA AGGCACACGC TCAATGCCCC 10080 ACGTGCCTTC TCCAGGAGGA ACGAACCAGG GTTTGAGGGT TGGGTGGATG GAGCTCAAAA 10140 GGAAACCCCA GCCCCACCAC GGATGACCCA TCCCTCCCGT CCCATCCCCA GCATGGGCAA 10200 GGCCAGCCTT TCTGGCAAAA GGAGCTGTCC TCAACTCAGG GCCGCTGTGA GCAAAGCTGA 10260 CCCCAGCCCC CACCCCCAGT TAACACTGCT GCTTCTCTGA ATGCATGTCA CCCTGCACCC 10320 CATGCTCCGG GCCCACACCC TGCAGGACAA GGAGCTCCAG ACAGGACGTC CATAAGTCAC 10380 CGAGGTGTGC CACCCAGCAG GTGCTGGAGG TGCCCAATGC TCCCTCCTAG GACCTCGCAG 10440 CCAGGCAAGG CTGTCAGGTT GTTTTGGGGG AAAAGGGGGT CATGGATGGC TGAACAAAAA 10500 GCGGGGAAAA TGCAGGCTGA GTGGGGCGAC CTCCTGCCTG CCAGGAGCCC CCTTTCAGGA 10560 CACAGCGGGG GTCTCACACT TGCTGTCCCC ATCCATGGCC CGAGGGGGAA CCTGGTGGTC 10620 TCTTCTGAGC TTTTGGACTT GGGGATGCCA AACACGTGCT CACCCTCACA CTCGCCCCGG 10680 CCCGCTGCGC CCCTAATTGC CAAAGGGTAG GGAAATGGCG AAGCCAGCCA CCAGGTCGCT 10740 GGTGACAGGG CCAGGGTTAT GCAGGAAGGT GGTGCGGCAT TGCCTTCCAC ATATGTAAGT 10800 CTCTGGGCGG CGCCCTCCCA GCTCCCTGCC TCTGTTTCCC CATGTGGGCC GTGGGGAACT 10860 CCCAGAGCTA CCTCTTGGGG GAGCGTGGTG GCAGCGATGA TGGGGAGACG CCTGGAAGCT 10920 CACAGAACTT GGGTCTGGCT GGCTCCTGCC CGTGACGCCT TGCCCAGCAG CAAGGTGCGC 10980 AACATGGCTG CCAGCCCCGC CTCCCACCCC CACCCCGAGT CCTGAGCTCA CTTTCGCCTT 11040 CTCCATCCCC TGCCGTGGGG GCCACAGCCA CACCTCACCG CCCAGTCCAG CTGTGCTCCA 11100 GAAGGGGACA GGCAGTCCGC GGTCTCTGGA CAATCAACTC AAGGTACGCC CACTGCAAGG 11160 CCTCCCTCCC ACCGCGGCCC CTGCCTGGCC ACCTGGCCTC TCTGCACCAG GGTGACAAGG 11220 GGTCCTCGTC TGCCCCCCAA TGCTCCAGGG CCAGTCCTAA GGAGCTGAGG GTCTGAGGAC 11280 GCAGGGAGGG TGGAGGTGTC CTGAGGCTGA TGGACAGTGA CCGCCACTGG CCCCCAACAT 11340 GACCACACGT GGGTGCTGAA CTCGGGGCGC CGTGCCCACC GGCATGGTCC TCCCGAGCTC 11400 CGACAGCATT ACCTCACCCG GCCCCATCTG TTGCCCCGGT CCAGCCCTGA TGGCGCGCGC 11460 CTGGTCTGTC TGATTCCCCT AGCCGCCACC CCACGTTTCT GTACCGGGTT TCTGCAGTGT 11520 TAAACGGACG TGTAAATAGT GGTAAATAGT GAAAGCCTGT CCTTCCCTAA ATGTAAAGCC 11580 ATCTGTCCGG CGTAAGGACG ACACCGTCAG CTGTCCGACT CGCACACATT TAATAAACTG 11640 AGCTCTTGC 11649 Seq ID NO : 138 DNA Sequence Nucleic Acid Accession # : NM 006365. 1 Coding sequence : 118.. 588 1 11 21 31 41 51 CTCCTCACAG AAGCCTGGAG CTGGGCATCC AAGAAGAAGC AGCCTCATTT GTTTTCTGGT 60 GTCATCGTAG GTGGCCACCT ATGGCTTTTG GGAATGTAAA AAGGGCAGCT CTCTGGCATG 120 TTCCTGACTG AGGATCTCAT AACATTTAAC TTGAGGAACT TCCTCCTTTT CCAGCTTTGG 180 GAGTCAAGCT TCTCACCTGG GGCGGGTGGG TTCTGCACCA CCCTCCCACC CTCCTTCCTC 240 CGTGTGGACG ATAGAGCCAC ATCCAGCACC ACGGACAGCT CCCGGGCGCC TTCATCTCCT 300 CGTCCTCCAG GCAGCACAAG CCATTGTGGA ATCTCCACCA GGTGTACAGA ACGGTGCCTC 360 TGCGTCCTGC CACTCAGGAC CTCTCAAGTC CCCGATGTGA TGGCTCCTCA GCATGATCAG 420 GAGAAATTCC ATGATCTTGC TTATTCCTGT CTTGGGAAGT CCTTCTCCAT GTCTAACCAA 480 GATCTATATG GCTATAGCAC CAGCTCTTTG GCTCTTGGCT TGGCATGGCT AAGTTGGGAG 540 ACCAAAAAGA AGAATGTACT TCATCTGGTT GGGCTGGATT CCCTCTGATA AGCCTTCCCA 600 GTTGACTGAA AGATGAGGCT AGGCTCTAGC AAGTTGAAGT CAAACCAGCT CCTTCAAGAA 660 GCTTTGAGCA GAATGAAGTG GGGAGGACCC AGCTTCCAGC CCAGGAAGCC CACTGTACCT 720 GGAGCCATCT GGGATAAGAC TTTGACCCAT GACTCCCATA TCCACAGCCT GTCCATCCTA 780 GCCCATCCCA GTTTATCCTG TATCATTTGA GCTGGGATTC CCACATCCTC TGAGTTGGAA 840 GTCCCATCTC AAGTCTTCAA TAAAGACTCT TGAATATTG 879 Seq ID NO : 139 DNA Sequence Nucleic Acid Accession 0 : BC032726. 1 Coding sequence : 48.. 2135 1 11 21 31 41 51

CCACGCGTCC GGAACGTCTT TTTGCGGACG CCCTCGGAGC AGCCGCGATG GCCAGCACCA 60 GGAGTATCGA GCTGGAGCAC TTTGAGGAAC GGGACAAAAG GCCGCGGCCG GGGTCGCGGA 120 GAGGGGCCCC CAGCTCCTCC GGGGGCAGCA GCAGCTCGGG CCCCAAGGGG AACGGGCTCA 180 TCCCCAGTCC GGCGCACAGT GCCCACTGCA GCTTCTACCG CACGCGGACC CTGCAGGCCC 240 TCAGCTCGGA GAAGAAGGCC AAGAAGGCGC GCTTCTACCG GAACGGGGAC CGCTACTTCA 300 AGGGCCTGGT GTTTGCCATC TCCAGCGACC GCTTCCGGTC CTTCGATGCG CTCCTCATAG 360 AGCTCACCCG CTCCCTGTCG GACAACGTGA ACCTGCCCCA GGGTGTCCGC ACTATCTACA 420 CCATCGACGG CAGCCGGAAG GTCACCAGCC TGGACGAGCT GCTGGAAGGT GAGAGTTACG 480 TGTGTGCATC CAATGAACCA TTTCGTAAAG TCGATTACAC CAAAAATATT AATCCAAACT 540 GGTCTGTGAA CATCAAGGGT GGGACATCCC GAGCGCTGGC TGCTGCCTCC TCTGTGAAAA 600 GTGAAGTAAA AGAAAGTAAA GATTTCATCA AACCCAAGTT AGTGACTGTG ATTCGAAGTG 660 GAGTGAAGCC TAGAAAAGCC GTGCGGATCC TTCTGAATAA AAAGACTGCT CATTCCTTTG 720 AACAAGTCTT AACAGATATC ACCGAAGCCA TTAAACTAGA CTCAGGAGTC GTCAAGAGGC 780 TCTGCACCCT GGATGGAAAG CAGGTTACTT GTCTGCAAGA CTTTTTTGGT GATGACGATG 840 TTTTTATTGC ATGTGGACCA GAAAAATTTC GTTATGCCCA AGATGACTTT GTCCTGGATC 900 ATAGTGAATG TCGTGTCCTG AAGTCATCTT ATTCTCGATC CTCAGCTGTT AAGTATTCTG 960 GATCCAAAAG CCCTGGGCCC TCTCGACGCA GCAAATCACC AGCTTCAGTT AATGGAACTC 1020 CCAGCAGCCA ACTTTCTACT CCTAAATCTA CGAAATCCTC CAGTTCCTCT CCAACTAGTC 1080 CAGGAAGTTT CAGAGGATTA AAGATTTCTG CTCATGGCAG ATCTTCTTCC AATGTAAACG 1140 GTGGACCTGA GCTTGACCGT TGCATAAGTC CTGAAGGTGT GAATGGAAAC AGATGCTCTG 1200 AATCATCAAC TCTTCTTGAG AAATACAAAA TTGGAAAGGT CATTGGTGAT GGCAATTTTG 1260 CAGTAGTCAA AGAGTGTATA GACAGGTCCA CTGGAAAGGA GTTTGCCCTA AAGATTATAG 1320 ACAAAGCCAA ATGTTGTGGA AAGGAACACC TGATTGAGAA TGAAGTGTCA ATACTGCGCC 1380 GAGTGAAACA TCCCAATATC ATTATGCTGG TCGAGGAGAT GGAAACAGCA ACTGAGCTCT 1440 TTCTGGTGAT GGAATTGGTC AAAGGTGGAG ATCTCTTTGA TGCAATTACT TCGTCGACCA 1500 AGTACACTGA GAGAGATGGC AGTGCCATGG TGTACAACTT AGCCAATGCC CTCAGGTATC 1560 TCCATGGCCT CAGCATCGTG CACAGAGACA TCAAACCAGA GAATCTCTTG GTGTGTGAAT 1620 ATCCTGATGG AACCAAGTCT TTGAAACTGG GAGACTTTGG GCTTGCGACT GTGGTAGAAG 1680 GCCCTTTATA CACAGTCTGT GGCACACCCA CTTATGTGGC TCCAGAAATC ATTGCTGAAA 1740 CTGGCTATGG CCTGAAGGTG GACATTTGGG CAGCTGGTGT GATCACATAC ATACTTCTCT 1800 GTGGATTCCC ACCATTCCGA AGTGAGAACA ATCTCCAGGA AGATCTCTTC GACCAGATCT 1860 TGGCTGGGAA GCTGGAGTTT CCGGCCCCCT ACTGGGATAA CATCACGGAC TCTGCCAAGG 1920 AATTAATCAG TCAAATGCTT CAGGTAAATG TTGAAGCTCG GTGTACCGCG GGACAAATCC 1980 TGAGTCACCC CTGGGTGTCA GATGATGCCT CCCAGGAGAA TAACATGCAA GCTGAGGTGA 2040 CAGGTAAACT AAAACAGCAC TTTAATAATG CGCTCCCCAA ACAGAACAGC ACTACCACCG 2100 GGGTCTCCGT CATCATGTTT GATTTGACAG TTTGAGAGGC ACCTCAGAGT TTCCTTCTTT 2160 ACCCCGCTGA GACAGTGGGA GAGCCTGAAG CAGAATCCTG AACACGGCTC TAGATAAGGA 2220 GGGGCAGATT TTCTGCAGCA AGCACTGTCA AGACAGCGGC AGGCCTGGGA TGGAGCCCAT 2280 CTCTCCAGTT CCTCCCTCAG TGGAGGAGAT CCCTGTGCCT GGGGAAGCAG TCCCGGCCCC 2340 CACCCCTCCG GAATCTCCCA CCCCCCACTG TCCTCCCGCT GCCCCGGGTG GTGAGCGGGC 2400 AGGAACCTGG CGCCGCCACC GAGACTGAGC CTCCTGCAGA CGGGCGAAGC CGCCTGCTGC 2460 CGCCCAGGAA GCCAGCCCTC TGCTCGGCCT CGCCGGCCTC CCTGCTGCAG GCCTCCCTCT 2520 CTTCACCGCC TGCGCCTGAG TTCGCGGGTC CTCCGCAGGC CGCCTGGGAA CCGGAGCCTG 2580 GCGTGCCGGA GCCTGGCCTG GTGCTCTGGG CTCTGCCTTC TGGTTCCTGG AGGCATCAAA 2640 GGCTGCATCC GTTCTGCCAA CAGCTGTTCG GAGAGACTCG TTCCAGATCA TCCCGTCATT 2700 TTCAGTTTGT TGGACATTTT ACAGCTTCAC CAGGAGAATG TGCAACTTTA TTCCAGCATT 2760 CGATGCATTT TTATAGAAAC ACTTTGGAAA CACTTTGGAT GAACCAAGGC CTTTTCCTTA 2820 TTTAAGTAGA CTCAGAACAC TCCCTTTCTT TTCTTTTCTC TCTCTCTCTC TCTTTTTTTT 2880 TACGAAAGAC TTAGAATTGC ATTTGTCCTT TTGTGGGTGT CCTGTGAGAG GTGATATGGG 2940 GGCTAAGAGG ACTGGCTTTC TAATAGAAGA AGTGAGCGCC TGAGAGGACA ATTTGGTCAT 3000 TGGACACGGA TTGCAGGCTT TGAGAAGCGC TCAGAGGCCC AGGGCGGCGG GCTCAGCCAT 3060 TCGGCTTGGG GCACCAGGCT CCCCAGAGAC AATGCTCAGT ATTCATTCAT ACACAGACGA 3120 TGGAAGAAGC CACTTCTTCC CTGGGCGGTG TGGGTTTCCC CCAGCTCTTC CCACACGTGT 3180 GTTAGGAAAT GCCCGTGAAC TTGCCCTCTG GGCTTTTTAA TGAGAGGCTT GGCGCATGCG 3240 GCACCCAGCG GCTGCTTCCC TGCAAGCCAG CGACTTGCCG AGCAGAATGA GCTCTGCTCC 3300 TGAGCCCCGG TAGCTGCTTC CTCATCTGCA TTTCATCTGG AGCAGGGCAG GTAACCACAG 3360 GAGGAGGCAT GCCCGAGGCA GCCAGGACTG GGCGGGAAGG TGCTCCCTGG ATATACTCTG 3420 TGAACCTTCT GGAAGGCTGC TGGCAGTTTT TCCTTTTTGT CCACCACCCT GCTCTTTTTA 3480 ATAATTGTAC ATAATCCGTG TATTTGTTTT ACCTGCTCAT CTTCTAAACT GGCGAGCCCT 3540 ATAGTTCGTT CTCATTGTTA GATTTTGCCT TTTACAAGTG TCCCCAACCT GCAATAAACT 3600 TTTCCCTCTT GAAAAAAAAA AAAAAA 3626 Seq ID NO : 140 DNA Sequence Nucleic Acid Accession t : Nom 015163. 2 Coding sequence : 1801.. 3933 1 11 21 31 41 51 GAAGAAATCG AGAAAACAAG AAAGCACGAA AGCAAGCAAG CAAGAAAGCA AGCAAGAAAG 60 AAACAAAAGA AAGAAAGAAA GAAAGAAAAC AGGAAAGCAA GAAAGCACGA AAGCAAGCAA 120 GCAAGCAAGA AAGCAAGCAA GAAAGAAACA AAAGAAAGAA AGAAAGAAAG AAAGAAAAAG 180 AAAACAGGAA AGCAAGAAAG CACGAAAGCA AGCAAGCAAG CAAGAAAGCA AGCATGAAAG 240 AAACGAAAGA AAGAAAGAAA GCAAGAAAAC GGGAAAGCAA GAAAGCACGA AAGCAAGCAA 300 GCAAGCGAGC GAGAGAGAGA GAGAGAGAGA GAGAGAGAGA GAGAGAGAGA GAGAGAGAGG 360 CTGGGCGCGG TGGCTCACGC CTGTCATCCC AGCACTTTGG GAGGCTAAGG CAGGCGGACC 420 ACCTGAGGTT GGGAGTGGGA GACCAGCCTG ACCAACATGG AAAAACACCG TCTCTACTAA 480 AAGTACAAAC ATCAGCCAGG CACGGTGGCC CATGCCTGTA ATCCCAGCTA ATCAGGAGGC 540 TGAGGCAGGA GAATCGCTTG AACCTGGGAG GCGGAGGGTG CGGTGAGCCG AGATCGCACC 600 ATTGCCCTCT AGCCTGGGCA ACAAGAGTGA AACTCTGTCT CAAAAAAAAA AAGAAGAAGA 660 AGAAGAAGAA GAAGAAGAAG AAGAAGAAGA AGAAGAAGAA GAAGAAGAAG AAGAAGAGAA 720 AGTAATAAAG AAAGAAAGAA AGAAAAGGCA AGGCCAGGCA AGTCCAGGCA AGGCAAATCT 780 ACCTGCTTTC ACTACATCTG GGGAGAATCA GGAAAGTCCC CAACAACAAC AAGGCCTAAA 840 GTGGAGCTGC CATCTGTCAA ACCCGAGCGG AAGAGTCCAC GCGGGTTAAA GACACGAAGA 900 AAGACAAGGA AACCCCTGAC CAAGGAGAAG AACAATCGGG CCCAGCCAGG GTCTGTCTCC 960 CGGGGTTGTC TGGGCAACCA GGGAGGGCGG GCCTCCGAGA CTCCGTCTCG AAACATCAAT 1020

CACGATAATA ACATAAAATG AAGTTAAAAA AAGAAATCAC GCATAATTCC TAACGTGTTT 1080 GAGGCCTCGA AAGGCGAGAG GCGTACGTGT ATGTCACGGT GGGGTTGTTC TGTTTTGTTG 1140 TTTTTTTCTT TTTTCTTTTC TTCTTTTTCC CCAGAAACTC ACTTTTTAAT TATTTTGTTG 1200 CGTTTCATTT TCATTTTCAT TTTTTGGAGA CGGAGTCTCG CTCTGTCGCC CAGGCTGGGT 1260 TGCAGTGGCG CGATCTCGGC TCACTGCAAC CTCCGCCTCC CAGGTTCAAG CGATTCTCCT 1320 GCCTCAGCTC GGCCTCCCGA GTAGCTGGGA TTACAGACAG TACAGCACAG CACAGCGCCC 1380 GGCTAATGTT GTGTATTGTG AGTAGAGACG GGGTTTCACC ATACTGGCCC TGTTGGTCTG 1440 ACCGCCTCTT GATCCACCGG CCTTGGCCTC CCAAAGTGAG GGGATGACAG GCTTGAGCCA 1500 CCGCGCAGGG CCCATTTATT TATTTTATTT TATTTATTTA TTTTAATTTA TGTATGTATG 1560 TATGTATGTA TGTATGTATT TATTTATGTA TTTATTTTTG AGACGGAGTT TCGCTCTTGT 1620 TGCTCAGACT GGAGTGCGAG CTAGCGCCTC TCTGGGTGTC CGTGCCAGTG CTGCGCGGGA 1680 AGGCACCACC ACCACAGCCG CCGCCGCTGG CCAGGGTGCT GGACAAGACG GGCCCGTCGG 1740 CCACCTCGCC AGCTCAGGCA CCCGCTGCAG CCGTCGCTGT CTCCTCCCAG ACCGGTCCCC 1800 ATGGAGGAGA TGGAAGAGGA GTTGAAATGC CCCGTGTGCG GCTCCTTCTA TCGGGAGCCC 1860 ATCATCCTGC CCTGCTCTCA CAATTTGTGT CAGGCGTGCG CCCGCAACAT CCTGGTGCAG 1920 ACCCCAGAGT CTGAATCCCC CCAGAGCCAT CGGGCCGCGG GCTCCGGGGT CTCCGACTAT 1980 GACTATCTGG ACCTGGACAA GATGAGCCTA TACAGCGAGG CGGACAGCGG CTATGGCTCC 2040 TACGGGGGGT TCGCCAGCGC CCCCACTACC CCGTGCCAGA AGTCCCCCAA CGGCGTCCGC 2100 GTGTTTCCCC CGGCTATGCC GCCACCGGCC ACCCACTTGT CACCGGCCCT GGCCCCGGTG 2160 CCCCGCAACT CCTGTATCAC CTGCCCCCAG TGTCACCGCA GCCTCATCCT GGATGACCGG 2220 GGGCTCCGCG GCTTCCCCAA GAATCGCGTA CTGGAAGGGG TAATTGACCG CTACCAGCAG 2280 AGCAAAGCCG CGGCCCTCAA GTGCCAGCTC TGCGAGAAGG CGCCCAAGGA AGCCACCGTC 2340 ATGTGCGAAC AGTGCGATGT CTTCTACTGC GATCCGTGCC GCCTGCGCTG CCACCCGCCC 2400 CGGGGGCCCC TAGCCAAGCA CCGCCTGGTG CCCCCGGCCC AGGGTCGTGT GAGCCGGAGG 2460 CTGAGCCCAC GCAAGGTCTC CACCTGCACA GACCACGAGC TGGAGAACCA CAGCATGTAC 2520 TGCGTGCAAT GCAAGATGCC CGTGTGCTAC CAGTGCTTGG AGGAGGGCAA ACACTCCAGC 2580 CACGAAGTCA AGGCTCTGGG GGCCATGTGG AAACTACATA AGAGCCAGCT CTCCCAGGCG 2640 CTGAACGGAC TGTCAGACAG GGCCAAAGAA GCCAAGGAGT TTCTGGTACA GCTGCGCAAC 2700 ATGGTCCAGC AGATCCAGGA GAACAGTGTG GAGTTTGAAG CCTGTCTGGT GGCCCAATGT 2760 GATGCCCTCA TCGATGCCCT CAACAGAAGA AAAGCCCAGC TGCTGGCCCG CGTCAACAAG 2820 GAGCATGAGC ACAAGCTGAA GGTGGTTCGA GATCAGATCT CTCACTGCAC AGTGAAATTG 2880 CGCCAGACCA CAGGTCTCAT GGAGTACTGC TTGGAGGTGA TTAAGGAAAA TGATCCTAGT 2940 GGTTTTTTGC AGATTTCTGA CGCCCTCATA AGAAGAGTGC ACCTGACTGA GGATCAGTGG 3000 GGTAAAGGCA CACTCACTCC AAGGATGACC ACGGACTTTG ACTTGAGTCT GGACAACAGC 3060 CCTCTGCTGC AATCCATCCA CCAGCTGGAT TTCGTGCAAG TGAAAGCTTC CTCTCCAGTC 3120 CCAGCAACCC CTATCCTACA GCTGGAGGAA TGTTGTACCC ACAACAACAG CGCTACGTTG 3180 TCCTGGAAAC AGCCACCTCT GTCCACGGTG CCCGCCGATG GATACATTCT GGAGCTGGAT 3240 GATGGCAACG GTGGTCAATT CCGGGAGGTG TATGTGGGGA AGGAGACAAT GTGCACTGTG 3300 GATGGTCTTC ACTTCAACAG CACATACAAC GCTCGGGTCA AGGCCTTCAA CAAAACAGGA 3360 GTCAGCCCGT ACAGCAAGAC CCTGGTCCTC CAAACGTCTG AGGTGGCCTG GTTTGCTTTC 3420 GACCCTGGCT CGGCGCACTC GGACATCATC CTCTCCAATG ACAACCTGAC AGTGACCTGT 3480 AGTAGCTATG ATGACCGGGT GGTGCTAGGG AAGACTGGCT TCTCCAAGGG CATCCACTAC 3540 TGGGAGCTCA CGGTAGATCG CTATGACAAC CACCCTGATC CTGCCTTTGG TGTGGCTCGC 3600 ATGGACGTGA TGAAGGATGT GATGTTAGGA AAAGACGACA AAGCTTGGGC AATGTATGTG 3660 GACAATAACC GGAGCTGGTT CATGCACAAC AACTCGCACA CCAACAGAAC TGAGGGAGGG 3720 ATCACAAAAG GGGCCACAAT TGGGGTCCTC CTCGACTTAA ATAGAAAAAA CTTGACATTT 3780 TTTATCAACG ATGAACAACA AGGTCCCATA GCATTTGATA ACGTGGAGGG CCTCTTCTTC 3840 CCTGCGGTCA GCCTGAACAG GAACGTGCAG GTCACGCTGC ACACCGGGCT CCCAGTCCCC 3900 GACTTCTACT CCAGCAGAGC ATCAATAGCC TAAGGATGTG CCGTGGAGGC GCCAGCTGCC 3960 TGTTCTTACC TCCGCCTGCG AGAGCCACAG CAAGGAGCTC AGCCAGCCGT GGTGGGGTGC 4020 AGAGTTGGCA GGAGTGGGAG AAGGAGGAGA GAAAAGCTGG TCCTCTGCAG TCTTTACACC 4080 CACAGCTCTG CCCTTTTCCC TTTCAACCTC TCCTCCGCTG TCATGCCTGC TTCCGCTTCC 4140 ATGTCCAACA ATTCTAACCA ACAAAGGACC TAGACAGCCC ACCAAGTCAC TTGGTTCCCA 4200 CTCCCAGATT TTGCTTTTAT TTAACTTAAT TTTTTATGTA GGTGAGTTAT ATTTTCTTTC 4260 TTTTCTGATC AGGTTATTGG TGACTTACTG GACTGGCACC GCCAGGAGAA AATTCTCCTG 4320 CTAACTTTTT TTCTTAAGCT TTCTGTCAAA CAATGAGGTT GTAGGGGGAG GTAGGGAAGA 4380 ATGAGCTGAA TTTGTAGCAT ACAGCTTACC TGCTAGAATG TTCTTACCCT CTTACCTCTC 4440 CTGTAGCGTT AGCTCTGCAG AGCTAAGCTT TGGGAGAATG AATCTATCAC TGAGAAGTTT 4500 TACTACTCAT TGAAGCACAA AAATATCCGC TACACAGGTT CACATCAGGG TAGGATCGTT 4560 AGGATGGCTC TATAATTAGG ATAGGCCAGA ACCCTGGCCA CTGTATAAAA TTGGAAAGTC 4620 TCTAAGACAC AGGCAAACCA GGGGACTTAA TGATTTGGTT CGTTTATTTA ATAAAAGCTT 4680 TTAATTGAGA ACCTACTATT GACCAGGCAC TGTTCAAGAC ACTAGAACAT TATGTTCTAG 4740 ACACTGTGGG GACACAGTGG TGAACAGACA GGCATGGTCT CTGCCCTTCG GAGCTTATAT 4800 TCCAGTAGGA GAAAAAGCAA AAATAAAATA ATTATAAATG GTCATATGTA CTAGAAAGGA 4860 AATGGGCAAG GGTCAAAGAG ACTCATGGGC AAGATCTTTC AGGCTTCCTA GAATGATGCT 4920 AAAAATCCAC ACATTCTGGC CATAGCACCA GAAATGTACC AACTCAATGC CTTTTCAGCT 4980 GCACTATTTA ATTATGGTAC CTGCTGCCAC TCATCACAGA GCCCTTCTTG GTAGAAATGA 5040 TGTCAGCATT CTTATTTGCT GATGCTGCTA TGATACCACG CCTTAAAAAT TGACAGTTGA 5100 AAAAAAAAAG AGTGACCAGA GGGCAAAGGA CCCATTCTCA GTAATGGGAG ATCTTGAGTT 5160 GCAGTCCACA GCATTCACAT TCTCAGGATA AACATGCTTG TCTCCATATA TACTATCTGT 5220 GCCTGTTATG AATGAAAAAT CCATCCACTC TGCTGCCATT CACAGCCTAA TCTTCTGGAG 5280 TAGTCCAAAC AATGTTTGGA AAAACATGGG ACTGTATGTC ATTACTATGA CTGATAGCAG 5340 AATAATAATG CATCTTACTT CTATATAGAG ATAGACTTAC ATAGGTTACC CTTGAAATTC 5400 ATTAGTTTGT CATAAAGTTT TAGGAAAGGT AGGACCCGGA AAGAAGTTCT AATTAGTTGT 5460 CTAAATATTT TTCAGTGAGC CAAGAAATTC ACCATGAAAA AACAAGAATA ACAAATAGAA 5520 GGGAAGAGAT AGGATGGGAA AGCTAACAAA TTAAAGTTTT GGCAAAAAGG AATATATGTA 5580 AATAGCTAAT TATTTACTTT TGTGCTTACT TTATTTAGAT TATTTCTATC AGTTACAATC 5640 TTTTTCTAGT TAAGTGTACC TAATTTATGG AATGGGTGCT ATCCTGTTTA TGTGTGTCTT 5700 GGTTTTTCTT GGCTACAGAA AAACTGTTGC AGGGCAACAC TAGTTTGATA TTTGATTTAC 5760 TCTCCAATGA GACTCAATGG CTGGGCCGTG GTAGACTCAT AGTTCCTCTT GTTCTTTATT 5820 AAATTCATCC TGCTAATTAG ATTTCTAGTG ACTTGTAACA TGTAGTTTAC ACTGAATTGC 5880 AATTACAGAT GCATACAACT ACTATACTAG AAAAAATTGT CATTTCTGAT GTGCCAATAA 5940 ATGATTTTTA TGAGAGAAAA AAAAAAAAAA AAAAAAAA 5978

Seq ID NO : 141 DNA Sequence Nucleic Acid Accession # : NM_032636. 2 Coding sequence : 102.. 1103 1 11 21 31 41 51 GGGAGAAAGC CTGTTGCGTG GAAGATAAGG CGGCGCGGGA AGTGGACACA GGGTGGGCTG 60 GAGCTCAGAT CTAACTGGAC TCTCGCTCCT GCTGGCTGGA CATGGAGGAT TTGGAGGAAG 120 ATGTAAGGTT TATTGTGGAT GAGACCTTGG ACTTTGGGGG GCTGTCACCA TCTGACAGCC 180 GTGAGGAGGA AGACATAACA GTGTTGGTGA CTCCAGAGAA ACCACTTCGA CGGGGCCTCT 240 CCCACCGAAG TGACCCAAAT GCAGTGGCAC CTGCCCCCCA GGGTGTGAGG CTCAGCCTAG 300 GCCCCCTCAG TCCAGAGAAG CTGGAGGAGA TCCTCGATGA GGCCAACCGG CTGGCCGCTC 360 AGCTGGAGCA GTGTGCCCTG CAGGATCGGG AGAGCGCAGG CGAGGGCCTG GGGCCTCGCC 420 GAGTGAAGCC CAGTCCTCGG CGGGAGACCT TTGTGCTGAA GGATAGTCCT GTCCGAGACC 480 TGCTGCCCAC TGTGAACTCT TTGACGCGGA GCACCCCCTC CCCAAGCAGC CTGACGCCTC 540 GACTCCGGAG TAATGATAGG AAGGGGTCAG TCAGGGCTCT CCGGGCTACA TCTGGAAAGA 600 GGCCCTCCAA CATGAAGAGG GAGTCACCCA CTTGCAATCT GTTCCCTGCA TCCAAAAGCC 660 CAGCATCTTC TCCTCTTACC CGATCGACTC CCCCAGTCCG GGGGAGAGCC GGGCCCAGTG 720 GGAGAGCAGC AGCCAGCCCA CCCACCCCCA TCAGATCCGT CCTGGCCCCA CAGCCTTCTA 780 CCAGCAACTC TCAACGCCTG CCCCGGCCGC AGGGAGCAGC TGCTAAATCT TCCAGTCAAC 840 TGCCCATTCC CTCGGCCATC CCCAGGCCTG CCAGCCGAAT GCCACTCACC AGCCGGAGTG 900 TGCCACCTGG CAGAGGTGCC CTACCTCCGG ATTCTCTGTC AACTCGAAAA GGGCTTCCAA 960 GACCAAGCAC TGCAGGACAC AGAGTGCGGG AAAGTGGACA CAAGGTTCCT GTTTCCCAGC 1020 GACTAAATCT TCCTGTCATG GGTGCCACTC GCAGCAATCT GCAGCCCCCC AGGAAAGTGG 1080 CAGTCCCAGG ACCTACCAGG TAAAGAGATC AGGACAGCAA GCAAGACTTC AGTAGCAAAC 1140 CACTACAGTC AGTACCTGGA CTCGCCTCTA CCCAGCAGAC CCTGACTCCA GCAGATTCTG 1200 GCCCAGGGAC AGGAGGAAGA GATGCCACCA GGGCTGGTCT CCCAGGAGTA GAGACCATGG 1260 GAAATGGGGT GGATTAGGAT TGAGCTGGAG AAGACTTAAA CTCTCTGGGT TGAAAGAAGA 1320 TTAGGGGAAA AGAGGTCACC TTCCAGCAGT GAAATGAACA AATAGAAGAT GAGAAGTACA 1380 GGCAAGTGGT TTGTCTTTAT CCACCCCCAC TGTTGTGGTC AGCCCCAGAG AATTTTATCT 1440 TCTTCCTTGG CATTGGTTCA CTGGACATTT CCACGTGAGC GGCCTCCGTA GCTAACCTCC 1500 CTGCCCTCTG AGGAGCCATC TTCCTGAATC GCATTCTCTA CTGGACTCTG GCCTGCTTGG 1560 AGAGGTGGCA GCAGGCACCT GGTCTTCAGA AATTGTTTCC TGTGAATTCT GTGACTCCTA 1620 ATAGGCCAGT TTGTGATAAG CTTACTCTAT GAGTCTTCAT TTTTCTAAAA TAAAGTGAAT 1680 GTATTTTTAA AAAAAAAAAA AAAAAAA 1707 Seq ID NO : GAD8 DNA Sequence Nucleic Acid Accession # : Nom 022123. 1 Coding sequence : 76.. 2781 1 11 21 31 41 51 1 1 1 1 1 1 CCACGCGTCC GACGCCCCCC ACCCGGGAGG GGGGAGAGAG GCAAAAAGTA AGAGAGGAAA 60 AAAAATAGCA GGAAGATGGC GCCCACCAAG CCCAGCTTTC AGCAGGATCC TTCCAGGCGA 120 GAACGTTTAC AAGCATTGAG AAAGGAGAAA TCCCGAGATG CTGCTCGCTC CCGCCGGGGA 180 AAAGAAAACT TTGAGTTCTA TGAATTGGCC AAGTTGTTGC CTCTTCCTGC AGCCATTACC 240 AGCCAGCTCG ACAAGGCATC CATCATTCGA CTTACAATTA GCTATCTGAA AATGAGGGAC 300 TTTGCTAACC AGGGGGACCC TCCGTGGAAC TTGCGAATGG AAGGCCCTCC ACCTAACACA 360 TCAGTAAAAG GTGCACAGCG AAGGAGAAGC CCCAGTGCAC TAGCCATTGA AGTATTTGAA 420 GCACATTTGG GAAGCCACAT TTTGCAGTCC CTGGATGGCT TTGTATTTGC ACTAAATCAG 480 GAAGGAAAAT TTTTGTACAT TTCCGAAACA GTCTCCATCT ACCTAGGCCT CTCACAAGTG 540 GAGCTGACAG GCAGCAGTGT CTTTGACTAT GTCCACCCCG GAGATCACGT GGAGATGGCT 600 GAGCAGCTGG GCATGAAGCT CCCCCCTGGG CGGGGTCTCC TGTCACAGGG CACTGCTGAG 660 GACGGAGCCA GCTCAGCATC TTCCTCCTCT CAGTCGGAGA CCCCCGAGCC AGTGGAGTCA 720 ACCAGCCCCA GTCTGCTAAC CACTGACAAC ACTCTTGAGC GTTCCTTTTT CATCCGAATG 780 AAATCTACTC TGACCAAACG CGGTGTGCAC ATCAAATCAT CAGGATATAA GGTGATTCAC 840 ATAACAGGCC GGCTACGCCT GAGAGTGTCG CTGTCCCACG GGAGGACCGT CCCCAGCCAA 900 ATCATGGGTC TCGTGGTTGT TGCGCATGCC TTGCCTCCCC CTACGATCAA TGAAGTCAGA 960 ATTGACTGCC ATATGTTCGT CACTCGAGTA AATATGGACC TCAATATCAT TTACTGTGAA 1020 AATAGGATTA GTGATTATAT GGATCTGACC CCTGTAGATA TCGTAGGGAA GAGATGCTAC 1080 CACTTCATCC ATGCTGAAGA CGTGGAGGGC ATCAGGCACA GTCACTTGGA CTTGCTGAAT 1140 AAGGGTCAGT GTGTGACAAA GTACTATCGC TGGATGCAGA AGAACGGAGG ATATATTTGG 1200 ATACAGTCCA GTGCCACCAT AGCTATTAAT GCCAAGAATG CAAATGAAAA GAATATCATC 1260 TGGGTGAATT ACCTTCTTAG CAATCCTGAG TACAAGGACA CACCCATGGA CATCGCACAG 1320 CTCCCCCATC TGCCGGAGAA AACTTCCGAA TCCTCGGAGA CATCCGACTC TGAGTCAGAC 1380 TCTAAAGACA CCTCAGGTAT TACAGAGGAC AACGAGAACT CCAAGTCCGA CGAGAAGGGG 1440 AACCAGTCCG AGAACAGCGA AGACCCGGAG CCCGACCGGA AGAAGTCGGG CAACGCGTGT 1500 GACAACGACA TGAACTGCAA CGACGACGGC CACAGCTCCA GTAACCCGGA CAGCCGCGAC 1560 AGCGACGACA GCTTCGAGCA CTCGGACTTT GAGAACCCCA AGGCGGGCGA GGACGGCTTC 1620 GGTGCTCTGG GCGCGATGCA GATCAAGGTG GAGCGCTACG TGGAGAGCGA GTCGGACCTG 1680 CGGCTGCAGA ACTGCGAGTC ACTCACGTCC GACAGCGCCA AGGACTCGGA CAGCGCAGGC 1740 GAGGCGGGCG CGCAGGCCTC CAGCAAGCAC CAGAAGCGCA AGAAAAGGCG GAAACGGCAA 1800 AAGGGCGGCA GCGCCAGCCG CCGGCGCCTG TCCAGCGCGT CGAGCCCAGG CGGCCTGGAC 1860 GCGGGCCTGG TGGAGCCCCC GCGGCTGCTG TCCTCCCCCA ACAGTGCCTC GGTGCTCAAG 1920 ATCAAGACGG AGATCTCAGA ACCCATCAAT TTCGACAATG ACAGCAGCAT CTGGAACTAC 1980 CCGCCCAACC GGGAGATCTC CAGGAACGAG TCCCCCTACA GCATGACCAA GCCCCCCAGC 2040 TCTGAGCACT TCCCGTCCCC GCAGGGCGGC GGCGGTGGGG GTGGCGGTGG CGGGGGGCTG 2100 CACGTGGCCA TTCCCGACTC GGTCCTCACC CCGCCCGGCG CCGACGGCGC GGCCGCCCGC 2160 AAGACTCAGT TCGGCGCCTC GGCCACCGCG GCCCTGGCCC CCGTCGCCTC CGACCCGCTG 2220 TCACCCCCGC TCTCGGCGTC CCCGCGGGAC AAGCACCCCG GGAACGGCGG CGGGGGCGGG 2280 GGCGGGGGCG GCGGCGCGGG GGGCGGCGGC CCCAGCGCGT CCAACTCCTT GCTGTACACT 2340 GGGGACCTGG AGGCGCTGCA GAGGTTGCAG GCGGGCAACG TCGTGCTCCC GCTGGTGCAC 2400 AGGGTGACCG GGACCCTGGC CGCCACCAGC ACGGCCGCGC AGAGGGTCTA CACCACGGGC 2460 ACCATCCGCT ACGCGCCCGC CGAGGTGACC CTGGCCATGC AGAGCAACCT GCTGCCCAAC 2520 GCGCACGCTG TTAACTTCGT GGACGTTAAC AGCCCCGGCT TTGGCCTCGA CCCCAAGACG 2580 CCCATGGAGA TGCTCTACCA CCACGTGCAC CGGCTCAACA TGTCAGGACC GTTCGGCGGC 2640

GCAGTGAGCG CAGCTAGCCT GACGCAGATG CCCGCCGGCA ACGTGTTCAC CACGGCCGAG 2700 GGACTCTTCT CCACGCTGCC CTTCCCCGTC TACAGCAACG GCATCCACGC GGCACAGACT 2760 CTGGAGCGCA AGGAGGACTG AGGCGCCGCC CGTCCTGGGC CCGGCCAGGC CCCGCTTGGA 2820 GGAGGCATCG TCGGCATTTT CGTTTAGACC TTTAATTCTA GCACTTTGAA TTCGAGCAGG 2880 TCAGCGTCTT CTCTCGCCAC GACGGTCCCC ATTCCACCCC CTCTTTCTTT CACCTGACTT 2940 ATTCTTTCGT GTAAAGATAT GTTTATTTTT TGCCTTCAGA GGGTCAGACG ACCAGTTGCC 3000 TGCCGTTTTG TCTTCTTCTA AGGTGTGTGT TGGGTTGTTT TGCTTTCCTT TGCATCTTTA 3060 TTAAGATGTC TTTCATGTGT ATATGCCTCT GCCATAGAAT ACTCAGTCTT GTGGTCAAGA 3120 GAGTTCTCAA GTGACAACCA TTGGGGTTTC TTCATAAAGA TCTTGATATG ATCAAGATGG 3180 AAAGAGACAA GCATAAACAA TGTGCCCTGT TTGACTAAGT CAAATGAAAT AGGGTGGTTT 3240 TTGTTTCTGT TCCTAATTCC TTTAAAAAAT AGGGGGAATA GTATTTTAGA ATTTTATGCA 3300 GAATTTAATT CTCTTTTTAC GGTTAAGATT TTAAGATTTT CTTACTTGCA CATAAAAATA 3360 ATTTGGGTTC TTAAACTTAA TTTCTGGCCT GTGACTAGAA TGTTTAAAAA AAAAAAAAAC 3420 CCTCGTGC 3428 Seq ID NO : 142 DNA Sequence Nucleic Acid Accession # : XM166946. 2 Coding sequence : 1.. 1641 1 11 21 31 41 51 ATGGGCTCTG ACTCTCGGCT TCCTGAGATG GAGGAGAAAG GGTCTGGGGA CAAAGCTGGC 60 TGGTCCGGAG CTCTTCTGGC TGAGGTGAAG AACCAGGGCT TGAAACTATG TGAGTGGATG 120 CTGGTTTTGA AGGCAGAGCT GGTGGAATGG TACACGTCAG TGATTGTAGG GCAACAGGGG 180 CATCGATTAA AAATGGACCT TCTTAAGGAG AGGCACCACC GCAAGTACCT GCAGAAGCCT 240 ATCAAGCGCT GCAGCGGCCT CATGGGCCTG AACTGGAGTT TGAGACCAGC CATCTCTTCC 300 TCACCCCTTG CGAGGAGTCA AGAGAAACAC CACGGGGCAA AGGGAAACGA AGGAGTTAAG 360 GCGTTGAGCT TCAGAAAGCT CAGAAAACTA AAGCGACCCC CCACTCCTCC AAGCCAGGCT 420 AAGAGCTGGC GGGGGCGCAC GGGCAGCGCT GCGGACAGCC CGGGAGCCGC GGCGATGGCG 480 GTGCAGGCGG CGCTCCTCAG CACGCACCCT TTCGTGCCCT TCGGCTTCGG GGGCTCCCCG 540 GACGGGCTAG GGGGCGCCTT CGGAGCCCTG GACAAGGGCT GCTGTTTCGA GGACGATGAG 600 ACCGGGGCTC CGGCGGGTGC GCTGCTGTCG GGAGCCGAAG GAGGGGACGT GCGCGAGGCC 660 ACCCGCGATC TACTCAGCTT CATTGACTCG GCGTCCAGCA ACATCAAGCT GGCGCTGGAC 720 AAGCCGGGCA AGTCGAAGCG GAAGGTGAAC CACCGCAACG CCCCGACAGT CGCGGCCCCG 780 GCCCACGGCA AGGCTGCCCC CCGGCGGGAG GCGTCGCAGG CCGCCGCGGC CGCCAGCTTG 840 CAAAGCCGAA GTCTGGCCGC GCTCTTCGAC TCGCTGCGCC ACGTCCCCGG GGGTGCCGAG 900 CCGGCGGGGG GTGAGGTGGC TGCGCCGGCG GCCGGGCTAG GAGGTGCGGG CACTGGGGGC 960 GCGGGAGGGG ACGTGGCAGG CCCCGCGGGG GCCACGGCGA TCCCAGGGGC CAGGAAGGTC 1020 CCGCTGCGGG CACGCAATCT GCCTCCGTCC TTCTTCACGG AGCCGTCCCG GGCAGGCGGC 1080 GGCGGGTGTG GCCCGTCGGG GCCGGACGTG AGCTTGGGCG ACCTGGAGAA GGGCGCGGAG 1140 GCCGTGGAGT TCTTTGAGCT GCTGGGGCCC GACTACGGCG CCGGCACGGA GGCGGCAGTC 1200 TTGCTTGCCG CCGAGCCTCT CGACGTGTTC CCCGCCGGAG CCTCCGTACT GCGGGGACCC 1260 CCGGAGCTGG AGCCCGGCCT CTTTGAGCCG CCGCCGGCAG TGGTGGGAAA CCTACTGTAC 1320 CCCGAGCCCT GGAGCGTCCC GGGCTGCTCC CCGACCAAAA AGAGCCCCCT GACTGCCCCC 1380 CGCGGCGGCT TGACCTTGAA CGAGCCCTTG AGCCCCCTGT ACCCCGCCGC TGCGGATTCT 1440 CCCGGCGGGG AGGACGGGCG GGGCCATTTG GCCTCTTTCG CCCCCTTCTT TCCAGACTGC 1500 GCCCTGCCCC CGCCGCCGCC GCCCCATCAG GTGTCCTACG ATTACAGCGC GGGCTACAGC 1560 CGCACCGCCT ATTCCAGCCT TTGGAGATCC GACGGGGTTT GGGAAGGGGC GCCGGGGGAG 1620 GAGGGGGCGC ACCGGGACTG A 1641 Seq ID NO : 143 DNA Sequence Nucleic Acid Accession # : NM 022123. 1 Coding sequence : 76.. 2781 1 11 21 31 41 51 CCACGCGTCC GACGCCCCCC ACCCGGGAGG GGGGAGAGAG GCAAAAAGTA AGAGAGGAAA 60 AAAAATAGCA GGAAGATGGC GCCCACCAAG CCCAGCTTTC AGCAGGATCC TTCCAGGCGA 120 GAACGTTTAC AAGCATTGAG AAAGGAGAAA TCCCGAGATG CTGCTCGCTC CCGCCGGGGA 180 AAAGAAAACT TTGAGTTCTA TGAATTGGCC AAGTTGTTGC CTCTTCCTGC AGCCATTACC 240 AGCCAGCTCG ACAAGGCATC CATCATTCGA CTTACAATTA GCTATCTGAA AATGAGGGAC 300 TTTGCTAACC AGGGGGACCC TCCGTGGAAC TTGCGAATGG AAGGCCCTCC ACCTAACACA 360 TCAGTAAAAG GTGCACAGCG AAGGAGAAGC CCCAGTGCAC TAGCCATTGA AGTATTTGAA 420 GCACATTTGG GAAGCCACAT TTTGCAGTCC CTGGATGGCT TTGTATTTGC ACTAAATCAG 480 GAAGGAAAAT TTTTGTACAT TTCCGAAACA GTCTCCATCT ACCTAGGCCT CTCACAAGTG 540 GAGCTGACAG GCAGCAGTGT CTTTGACTAT GTCCACCCCG GAGATCACGT GGAGATGGCT 600 GAGCAGCTGG GCATGAAGCT CCCCCCTGGG CGGGGTCTCC TGTCACAGGG CACTGCTGAG 660 GACGGAGCCA GCTCAGCATC TTCCTCCTCT CAGTCGGAGA CCCCCGAGCC AGTGGAGTCA 720 ACCAGCCCCA GTCTGCTAAC CACTGACAAC ACTCTTGAGC GTTCCTTTTT CATCCGAATG 780 AAATCTACTC TGACCAAACG CGGTGTGCAC ATCAAATCAT CAGGATATAA GGTGATTCAC 840 ATAACAGGCC GGCTACGCCT GAGAGTGTCG CTGTCCCACG GGAGGACCGT CCCCAGCCAA 900 ATCATGGGTC TCGTGGTTGT TGCGCATGCC TTGCCTCCCC CTACGATCAA TGAAGTCAGA 960 ATTGACTGCC ATATGTTCGT CACTCGAGTA AATATGGACC TCAATATCAT TTACTGTGAA 1020 AATAGGATTA GTGATTATAT GGATCTGACC CCTGTAGATA TCGTAGGGAA GAGATGCTAC 1080 CACTTCATCC ATGCTGAAGA CGTGGAGGGC ATCAGGCACA GTCACTTGGA CTTGCTGAAT 1140 AAGGGTCAGT GTGTGACAAA GTACTATCGC TGGATGCAGA AGAACGGAGG ATATATTTGG 1200 ATACAGTCCA GTGCCACCAT AGCTATTAAT GCCAAGAATG CAAATGAAAA GAATATCATC 1260 TGGGTGAATT ACCTTCTTAG CAATCCTGAG TACAAGGACA CACCCATGGA CATCGCACAG 1320 CTCCCCCATC TGCCGGAGAA AACTTCCGAA TCCTCGGAGA CATCCGACTC TGAGTCAGAC 1380 TCTAAAGACA CCTCAGGTAT TACAGAGGAC AACGAGAACT CCAAGTCCGA CGAGAAGGGG 1440 AACCAGTCCG AGAACAGCGA AGACCCGGAG CCCGACCGGA AGAAGTCGGG CAACGCGTGT 1500 GACAACGACA TGAACTGCAA CGACGACGGC CACAGCTCCA GTAACCCGGA CAGCCGCGAC 1560 AGCGACGACA GCTTCGAGCA CTCGGACTTT GAGAACCCCA AGGCGGGCGA GGACGGCTTC 1620 GGTGCTCTGG GCGCGATGCA GATCAAGGTG GAGCGCTACG TGGAGAGCGA GTCGGACCTG 1680 CGGCTGCAGA ACTGCGAGTC ACTCACGTCC GACAGCGCCA AGGACTCGGA CAGCGCAGGC 1740 GAGGCGGGCG CGCAGGCCTC CAGCAAGCAC CAGAAGCGCA AGAAAAGGCG GAAACGGCAA 1800

AAGGGCGGCA GCGCCAGCCG CCGGCGCCTG TCCAGCGCGT CGAGCCCAGG CGGCCTGGAC 1860 GCGGGCCTGG TGGAGCCCCC GCGGCTGCTG TCCTCCCCCA ACAGTGCCTC GGTGCTCAAG 1920 ATCAAGACGG AGATCTCAGA ACCCATCAAT TTCGACAATG ACAGCAGCAT CTGGAACTAC 1980 CCGCCCAACC GGGAGATCTC CAGGAACGAG TCCCCCTACA GCATGACCAA GCCCCCCAGC 2040 TCTGAGCACT TCCCGTCCCC GCAGGGCGGC GGCGGTGGGG GTGGCGGTGG CGGGGGGCTG 2100 CACGTGGCCA TTCCCGACTC GGTCCTCACC CCGCCCGGCG CCGACGGCGC GGCCGCCCGC 2160 AAGACTCAGT TCGGCGCCTC GGCCACCGCG GCCCTGGCCC CCGTCGCCTC CGACCCGCTG 2220 TCACCCCCGC TCTCGGCGTC CCCGCGGGAC AAGCACCCCG GGAACGGCGG CGGGGGCGGG 2280 GGCGGGGGCG GCGGCGCGGG GGGCGGCGGC CCCAGCGCGT CCAACTCCTT GCTGTACACT 2340 GGGGACCTGG AGGCGCTGCA GAGGTTGCAG GCGGGCAACG TCGTGCTCCC GCTGGTGCAC 2400 AGGGTGACCG GGACCCTGGC CGCCACCAGC ACGGCCGCGC AGAGGGTCTA CACCACGGGC 2460 ACCATCCGCT ACGCGCCCGC CGAGGTGACC CTGGCCATGC AGAGCAACCT GCTGCCCAAC 2520 GCGCACGCTG TTAACTTCGT GGACGTTAAC AGCCCCGGCT TTGGCCTCGA CCCCAAGACG 2580 CCCATGGAGA TGCTCTACCA CCACGTGCAC CGGCTCAACA TGTCAGGACC GTTCGGCGGC 2640 GCAGTGAGCG CAGCTAGCCT GACGCAGATG CCCGCCGGCA ACGTGTTCAC CACGGCCGAG 2700 GGACTCTTCT CCACGCTGCC CTTCCCCGTC TACAGCAACG GCATCCACGC GGCACAGACT 2760 CTGGAGCGCA AGGAGGACTG AGGCGCCGCC CGTCCTGGGC CCGGCCAGGC CCCGCTTGGA 2820 GGAGGCATCG TCGGCATTTT CGTTTAGACC TTTAATTCTA GCACTTTGAA TTCGAGCAGG 2880 TCAGCGTCTT CTCTCGCCAC GACGGTCCCC ATTCCACCCC CTCTTTCTTT CACCTGACTT 2940 ATTCTTTCGT GTAAAGATAT GTTTATTTTT TGCCTTCAGA GGGTCAGACG ACCAGTTGCC 3000 TGCCGTTTTG TCTTCTTCTA AGGTGTGTGT TGGGTTGTTT TGCTTTCCTT TGCATCTTTA 3060 TTAAGATGTC TTTCATGTGT ATATGCCTCT GCCATAGAAT ACTCAGTCTT GTGGTCAAGA 3120 GAGTTCTCAA GTGACAACCA TTGGGGTTTC TTCATAAAGA TCTTGATATG ATCAAGATGG 3180 AAAGAGACAA GCATAAACAA TGTGCCCTGT TTGACTAAGT CAAATGAAAT AGGGTGGTTT 3240 TTGTTTCTGT TCCTAATTCC TTTAAAAAAT AGGGGGAATA GTATTTTAGA ATTTTATGCA 3300 GAATTTAATT CTCTTTTTAC GGTTAAGATT TTAAGATTTT CTTACTTGCA CATAAAAATA 3360 ATTTGGGTTC TTAAACTTAA TTTCTGGCCT GTGACTAGAA TGTTTAAAAA AAAAAAAAAC 3420 CCTCGTGC Seq ID NO : 144 DNA Sequence Nucleic Acid Accession # : NM 005806. 1 Coding sequence : 105.. 1076 1 11 21 31 41 51 CCCTGAGGCT TTTCGGAGCG AGCTCCTCAA ATCGCATCCA GATTTTCGGG TCCGAGGGAA 60 GGAGGACCCT GCGAAAGCTG CGACGACTAT CTTCCCCTGG GGCCATGGAC TCGGACGCCA 120 GCCTGGTGTC CAGCCGCCCG TCGTCGCCAG AGCCCGATGA CCTTTTTCTG CCGGCCCGGA ISO GTAAGGGCAG CAGCGGCAGC GCCTTCACTG GGGGCACCGT GTCCTCGTCC ACCCCGAGTG 240 ACTGCCCGCC GGAGCTGAGC GCCGAGCTGC GCGGCGCTAT GGGCTCTGCG GGCGCGCATC 300 CTGGGGACAA GCTAGGAGGC AGTGGCTTCA AGTCGTCCTC GTCCAGCACC TCGTCGTCTA 360 CGTCGTCGGC GGCTGCGTCG TCCACCAAGA AGGACAAGAA GCAAATGACA GAGCCGGAGC 420 TGCAGCAGCT GCGTCTCAAG ATCAACAGCC GCGAGCGCAA GCGCATGCAC GACCTCAACA 480 TCGCCATGGA TGGCCTCCGC GAGGTCATGC CGTACGCACA CGGCCCTTCG GTGCGCAAGC 540 TTTCCAAGAT CGCCACGCTG CTGCTGGCGC GCAACTACAT CCTCATGCTC ACCAACTCGC 600 TGGAGGAGAT GAAGCGACTG GTGAGCGAGA TCTACGGGGG CCACCACGCT GGCTTCCACC 660 CGTCGGCCTG CGGCGGCCTG GCGCACTCCG CGCCCCTGCC CGCCGCCACC GCGCACCCGG 720 CAGCAGCAGC GCACGCCGCA CATCACCCCG CGGTGCACCA CCCCATCCTG CCGCCCGCCG 780 CCGCAGCGGC TGCTGCCGCC GCTGCAGCCG CGGCTGTGTC CAGCGCCTCT CTGCCCGGAT 840 CCGGGCTGCC GTCGGTCGGC TCCATCCGTC CACCGCACGG CCTACTCAAG TCTCCGTCTG 900 CTGCCGCGGC CGCCCCGCTG GGGGGCGGGG GCGGCGGCAG TGGGGCGAGC GGGGGCTTCC 960 AGCACTGGGG CGGCATGCCC TGCCCCTGCA GCATGTGCCA GGTGCCGCCG CCGCACCACC 1020 ACGTGTCGGC TATGGGCGCC GGCAGCCTGC CGCGCCTCAC CTCCGACGCC AAGTGAGCCG 1080 ACTGGCGCCG GCGCGTTCTG GCGACAGGGG AGCCAGGGGC CGCGGGGAAG CGAGGACTGG 1140 CCTGCGCTGG GCTCGGGAGC TCTGTCGCGA GGAGGGGCGC AGGACCATGG ACTGGGGGTG 1200 GGGCATGGTG GGGATTCCAG CATCTGCGAA CCCAAGCAAT GGGGGCGCCC ACAGAGCAGT 1260 GGGGAGTGAG GGGATGTTCT CTCCGGGACC TGATCGAGCG CTGTCTGGCT TTAACCTGAG 1320 CTGGTCCAGT AGACATCGTT TTATGAAAAG GTACCGCTGT GTGCATTCCT CACTAGAACT 1380 CATCCGACCC CCGACCACCA CCTCCGGGAA AAGATTCTAA AAACTTCTTT CCCTGAGAGC 1440 GTGGCCTGAC TTGCAGACTC GGCTTGGGCA GCACTTCGGG GGGGGAGGGG GTGTTATGGG 1500 AGGGGGACAC ATTGGGGCCT TGCTCCTCTT CCTCCTTTCT TGGCGGGTGG GAGACTCCGG 1560 GTAGCCGCAC TGCAGAAGCA ACAGCCCGAC CGCGCCCTCC AGGGTCGTCC CTGGCCCAAG 1620 GCCAGGGGCC ACAAGTTAGT TGGAAGCCGG CGTTCGGTAT CAGAAGCGCT GATGGTCATA 1680 TCCAATCTCA ATATCTGGGT CAATCCACAC CCTCTTAGAA CTGTGGCCGT TCCTCCCTGT 1740 CTCTCGTTGA TTTGGGAGAA TATGGTTTTC TAATAAATCT GTGGATGTTC CTTCTTCAAC 1800 AGTATGAGCA AGTTTATAGA CATTCAGAGT AGAACCACTT GTGGATTGGA ATAACCCAAA 1860 ACTGCCGATT TCAGGGGCGG GTGCATTGTA GTTATTATTT TAAAATAGAA ACTACCCCAC 1920 CGACTCATCT TTCCTTCTCT AAGCACAAAG TGATTTGGTT ATTTTGGTAC CTGAGAACGT 1980 AACAGAATTA AAAGGCAGTT GCTGTGGAAA CAGTTTGGGT TATTTGGGGG TTCTGTTGGC 2040 TTTTTAAAAT TTTCTTTTTT GGATGTGTAA ATTTATCAAT GATGAGGTAA GTGCGCAATG 2100 CTAAGCTGTT TGCTCACGTG ACTGCCAGCC CCATCGGAGT CTAAGCCGGC TTTCCTCTAT 2160 TTTGGTTTAT TTTTGCCACG TTTAACACAA ATGGTAAACT CCTCCACGTG CTTCCTGCGT 2220 TCCGTGCAAG CCGCCTCGGC GCTGCCTGCG TTGCAAACTG GGCTTTGTAG CGTCTGCCGT 2280 GTAACACCCT TCCTCTGATC GCACCGCCCC TCGCAGAGAG TGTATCATCT GTTTTATTTT 2340 TGTAAAAACA AAGTGCTAAA TAATATTTAT TACTTGTTTG GTTGCAAAAA CGGAATAAAT 2400 GACTGAGTGT TGAGATTTTA AATAAAATTT AAAGT 2435 Seq ID NO : 145 DNA Sequence Nucleic Acid Accession # : XM 045127. 3 Coding sequence : 21.. 4469 1 11 21 31 41 51 ATGGTGCCGA GACTCTGTGC ATGACCGTGC TGGAAGAAAG CAGCATCTCT CTAATGAGTA 60 GCGTCGTAGC AGACTTCTCT GAATTTGAGG AAGATCCTCA AGTATTTAAT ACGCTTTTCC 120 CCTCCAGACC TATCGTCCCA CTTTCTTCTA GATCCATGGA AATCTCAGAG ACGAGTGTTG 180

GCATTTCTGC CGAGGTGGAT ATGAGTAGTG TTACAACCAC ACAGGTTCCC CCTGCCCACG 240 GCCGCCTCTC TGTGCCGGCG TCACTTGATC CTACTGCTGG CTCCTTGTCT GTTGCTGAAA 300 CCCAAGTGAC GCCATCCAGC GTGACCACTG CATTTTTCTC GGTCATCACC AGCATTCTCC 360 TTGACTCATC TTTCTCTGTC ATAGCAAACA AAAACACACC GTCGCTTGCC GTCAGAGACC 420 CGAGTGTTTT TACGCCTTAT AGTCTGGTTC CTTCAGTGGA GTCTTCACTT TTCTCTGACC 480 AAGAACGTTC CAGTTTTTCT GAGCATAAAC CCAGAGGTGC TTTGGATTTT GCATCCAGCT 540 TTTTCTCAAC ACCCCCGCTG GAACTCAGCG GCTCCATCTC TTCGCCTTCG GAAGCACCTG 600 CGTCTCTGTC TCTGATGCCG AGTGACTTGT CCCCCTTCAC ATCTCAGTCT TTTTCTCCCT 660 TGGTTGAGAC ATTTACATTG TTTGACTCTA GTGATCTGCA GTCATCTCAG CTGTCTCTTC 720 CCAGTTCCAC AAATCTTGAG TTTTCGCAGC TCCAGCCAAG TTCCGAGCTG CCTTTAAACA 780 CCATCATGTT GCTACCTAGC CGTTCTGAGG TGTCACCATG GTCAAGCTTC CCTTCTGATT 840 CTCTCGAGTT TGTTGAAGCG TCTACGGTTT CACTGACGGA TTCAGAAGCT CATTTTACCT 900 CAGCTTTCAT TGAAACTACC TCCTATCTTG AGTCTTCACT CATTTCCCAT GAATCCGCAG 960 TCACTGCACT GGTGCCCCCC GGCTCTGAGT CTTTTGACAT TTTGACTGCC GGGATTCAAG 1020 CAACATCACC ATTGACCACT GTCCACACAA CGCCCATTTT AACTGAGTCT TCTTTGTTCT 1080 CAACTCTGAC ACCTCCTGAC GACCAAATCA GTGCTCTAGA CGGTCACGTG TCTGTCCTGG 1140 CCTCTTTCTC CAAAGCCATT CCCACTGGTA CGGTGTTGAT CACTGACGCG TACCTGCCAT 1200 CAGGATCCTC GTTTGTTTCT GAAGCAACCC CCTTCCCTCT GCCCACAGAG CTGACCGTCG 1260 TGGGCCCATC ACTCACACCC ACAGAGGTGC CACTGAACAC CTCCACGGAA GTGAGCACAA 1320 CCAGCACCGG TGCTGCCACT GGTGGTCCCC TCGACTCCAC CCTGATGGGT GACGCCGCAA 1380 GTCAGAGCCC CCCAGAGAGT AGTGCTGCTC CTCCCCTGCC ATCCCTGCGT CCCGTGACTG 1440 CCTTCACTCT CGAAGCAACA GTCGACACAC CAACACTGGC TACTGCCAAG CCGCCATATG 1500 TTTGTGATAT CACAGTCCCC GATGCCTATC TGATCACAAC TGTGCTGGCC AGAAGAGCTG 1560 TGCAGGAGTA CATCATTACA GCAATCAAAG AAGTACTGAG GATTCACTTC AACCGTGCAG 1620 TGGAACTGAA GGTTTACGAA CTATTTACTG ACTTCACTTT TCTGGTAACA TCCGGTCCTT 1680 TCGTTTACAC GGCAATATCC GTCATAAATG TGCTTATAAA CAGTAAGCTT GTCCGTGACC 1740 AGACTCCTTT AATCCTGTCT GTGAAACCTT CTTTCCTTGT GCCAGAGTCC AGGTTCCAAG 1800 TTCAAACAGT ACTTCAGTTT GTGCCTCCGA GTGTGGATAC TGGCTTCTGC AACTTCACCC 1860 AGCGCATTGA GAAAGGCCTA ATGACAGCTC TCTTTGAAGT GAGAAAACAC CACCAGGGAA 1920 CGTATAACCT CACGGTGCAG ATCTTGAATA TCACCATCAG TTCCTCAAGG GTGACTCCTC 1980 GGCGGGGCCC GGTGAATATC ATCTTTGCGG TTAAAAGCAC ACAGGGATTT TTGAATGGGT 2040 CGGAAGTGAG CGAGCTGCTC AGAAACTTGA GTGTGGTGGA GTTCAGTTTC TATCTGGGAT 2100 ACCCAGTGCT GCAGATCGCA GAGCCCTTCC AGTATCCACA GCTCAACTTA TCTCAGTTGC 2160 TGAAGTCCTC TTGGGTCAGA ACAGTTCTCC TGGGCGTCAT GGAGAAGCAA CTCCAGAATG 2220 AAGTGTTTCA AGCCGAGATG GAACGCAAGC TGGCCCAGCT GCTCAGCGAG GTTTCCACCA 2280 GAAGGCGGAT GTGGAGAAGG GCCACTGTAG CTGCAGGGAA CAGTGTGGTG CAGGTGGTAA 2340 ATGTGTCGAG GCTGGAGGGA GATGACAATC CGGTACAGCT CATCTACTTT GTGGAGGATC 2400 AAGATGGAGA AAGACTCAGT GCAGTCAAGT CTTCGGACCT GATTAACAAA ATGGACCTCC 2460 AGAGAGCAGC CATCATCTTG GGTTACCGAA TTCAAGGTGT CATTGCCCAG CCTGTCGACA 2520 GGGTGAAGAG GCCGTCTCCG GAATCCCAGA GCAACAACTT GTGGGTCATT GTTGGCGTGG 2580 TCATCCCAGT GCTGGTGGTG ATGGTGATTG TTGTCATCCT CTACTGGAAA CTATGCCGCA 2640 CAGACAAGCT AGACTTTCAG CCTGACACTG TGGCCAACAT TCAGCAGCGT CAGAAGCTGC 2700 AGATCCCTAG TGTGAAGGGC TTCGATTTTG CTAAGCAGCA TCTGGGTCAG CACAATAAAG 2760 ACGACATATT GATTATTCAT GAGCCAGCGC CACTGCCAGG ACCTCTGAAG GACCACACCA 2820 CGCCCTCGGA AAATGGAGAC GTGCCAAGCC CCAAGTCAAA GATCCCTTCC AAGAATGTTC 2880 GTCACAGAGG AAGAGTTTCT CCCTCAGATG CTGACTCTAC GGTCAGTGAA GAGTCCAGCG 2940 AGAGGGACGC AGGAGATAAG ACGCCGGGAG CCGTCAACGA TGGCAGGTCC CACAGAGCTC 3000 CGCAGAGCGG GCCACCACTG CCCAGTTCGG GAAATGAGCA GCACTCATCA GCCTCCATCT 3060 TCGAGCACGT GGACAGGATC TCCCGCCCCC CGGAGGCTAG CCGGCGGGTC CCCAGTAAGA 3120 TCCAGCTTAT CGCCATGCAG CCGATCCCGG CACCTCCCGT CCAGCGCCCC TCCCCAGCCG 3180 ACCGAGTGGC GGAAAGCAAT AAAATCAACA AAGAGATTCA GACCGCGCTG CGGCACAAGT 3240 CTGAGATCGA GCACCATCGC AACAAGATCC GCCTGCGCGC CAAGCGCCGC GGGCACTACG 3300 AGTTCCCGGT GGTAGACGAC CTGTCCTCGG GCGACACTAA GGAGCGACAC CGGGTGTACC 3360 GCAGGGCACA GATGCAGATC GACAAGATCC TGGACCCCAC GGCCAGCGTG CCCTCCGTGT 3420 TCATAGAGCC CAGGAAGAGC TCACGGATAA AACGTTCTCC CAAGCCTCGC CGGAAACACC 3480 AGGTCAACGG CTGTCCTGCC GACGCTGAGA AGGACCGGCT CATCACCACA GACAGCGATG 3540 GCACCTACAG GAGGCCCCCC GGCGTCCACA ACTCAGCCTA CATCGGATGC CCATCGGATC 3600 CTGACCTCCC AGCCGATGTG CAGACACCAT CCTCGGTGGA ACTGGGGAGG TATCCAGCCC 3660 TTCCCTTCCC GGCCTCCCAG TACATCCCAC CCCAGCCGTC CATCGAGGAG GCACGCCAGA 3720 CCATGCACTC CCTCCTGGAC GACGCCTTTG CCCTCGTGGC CCCCAGCAGC CAGCCTGCCA 3780 GCACCGCAGG TGTAGGCCCC GGAGTCCCAC CCGGCCTGCC CGCAAACAGC ACCCCTTCCC 3840 AGGAAGAGAG GCGAGCCACC CAGTGGGGGT CCTTCTACAG CCCAGCCCAG ACGGCCAACA 3900 ATCCCTGCAG TAGATACGAA GACTATGGAA TGACTCCCCC GACGGGTCCA TTGCCAAGAC 3960 CAGGTTTTGG CCCCGGTTTG CTGCAGTCTA CAGAGCTGGT GCCCCCTGAC CCTCAGCAGC 4020 CACAGGCCTC CGCCGAAGCC CCATTTGCTG CCAGAGGGAT CTACTCGGAG GAGATGCCGT 4080 CGGTGGCCCG GCCTCGGCCT GTCGGGGGTA CCACAGGCTC CCAGATCCAG CACCTGACAC 4140 AGGTGGGGAT TGCCAGCAGA ATTGGAGCTC AGCCAGTGGA AATCCCGCCA AGCAGAGGCA 4200 GCCAGTATGG GGGGCCAGGC TGGCCTTCGT ACGGGGAGGA CGAAGCGGGG CGAAGAGAGG 4260 CCGTGCCAAG GACTTCAGGC AGGGAGCCCT CAGCTCCTTC CGGGAACCTC CCCCACCGGG 4320 GACTGCAGGG CCCTGGGCTG GGTTACCCCA CCAGCTCCAC GGAAGACCTC CAGCCTGGCC 4380 ACTCCTCGGC CTCTCTCATC AAAGCAATCC GCGAGGAGCT CCTCCGGCTC TCCCAGAAAC 4440 AGAGCACCGT GCAGAACTTC CACAGCTGAT CGGCCTCGCC TCGCAGATTT GCCAAGTATC 4500 CGCTTCCTGT GGAAGCAAGA CCAAAAGGAA ATCAACTGAG TGGGTGTTTG GAAGAGGAAG 4560 GAGCAACTCT CGGGCAGCCT GCCCAAGGGA GGGAGCAAGT TGCAATTTAG AAGATGCCAT 4620 ACGTCGTGTG ACAGCTCATG AGCCTTTCAC TGGGCTGGCA ATTGTCTGAA CACTTGGGTT 4680 CAGTTGAAAT ATATGTATTT TGGCCAAAAG CCAGCAGCAC TTCACAAAAA CAAAACACAA 4740 ACCTAAGCTA ACAAAATGAC TGCATTCGTC TCTTTTTTAA AGGTAGAGAT TAAACTGTAT 4800 AGACAGCATA GGGATGAAAG GAACCAAGCG TTTCTGTGGG ATTGAGACTG GTACGTGTAC 4860 GATGAACCTG CTGCTTTGTT TTCTGAGAAG AGGTTTGAAG ACATTTTATT AACAGCTTAA 4920 TTTTTCTCTT TTACTCCATA GGAACTTATT TTAATAGTAA CATTAACAAC AAGAATACTA 4980 AGACTGTTTG GGAATTTTAA AAAGCTACTA GTGAGAAACC AAATGATAGG TTGTAGAGCC 5040 TGATGACTCC AAACAAAGCC ATCACCCGCA TTCTTCCTCC TTCTTCTGGT GCTACAGCTC 5100 CAAGGGCCCT TCACCTTCAT GTCTGAAATG GAACTTTGGC TTTTTCAGTG GAAGAATATG 5160 TTGAAGGTTT CATTTTGTTC TAGAAAAAAA AAATCCCTCC CAAAGTGGGG CAAAAAGCTT 5220

TATATTTATT TGATTATCCA AAATACAGAT CAAAGTTTAG ATCT 5264 Seq ID NO : 146 DNA Sequence Nucleic Acid Accession # : AK096568. 1 Coding sequence : 63.. 797 1 11 21 31 41 51 ATCTTCGGCG GGCGAGTGGG CTCGGCCTGT GCAACCCGCA CCTGCGTCCC TCGCCCGGCC 60 CGATGGCGCC GCGGCCGCTG GGCCCCTTGG TGCTGGCGCT CGGCGGCGCC GCGGCGGTGC 120 TGGGCTCGGT GCTCTTCATC CTCTGGAAGA CCTACTTCGG CCGCGGCCGA GAGCGGCGCT 180 GGGACCGGGG AGAGGCCTGG TGGGGCGCGG AGGCTGCCCG CCTCCCCGAG TGGGACGAGT 240 GGGACCCCGA GGACGAGGAG GACGAGGAGC CGGCGCTGGA GGAGCTGGAA CAGCGCGAGG 300 TGCTGGTGCT GGGGCTGGAT GGCGCAGGCA AGAGCACGTT CCTGCGCGTG TTGTCGGGGA 360 AGCCACCGCT GGAAGGCCAC ATCCCCACCT GGGGCTTCAA CTCCGTGCGT CTGCCCACCA 420 AGGACTTTGA GGTGGACCTG CTAGAAATTG GGGGCAGCCA GAACCTGCGC TTCTACTGGA 480 AGGAGTTTGT GAGCGAGGTG GATGTGCTGG TGTTTGTGGT GGACTCGGCT GACCGACTGC 540 GGCTGCCCTG GGCCCGACAG GAGCTGCACA AGCTGCTGGA CAAGGACCCT GACCTGCCTG 600 TCGTCGTGGT GGCCAACAAG CAGGACCTGA GCGAGGCCAT GAGTATGGGG GAGCTGCAGC 660 GGGAGCTGGG TCTACAGGCT ATCGATAACC AGCGGGAGGT TTTCCTCTTG GCAGCCAGCA 720 TTGCCCCTGC AGGACCCACC TTTGAAGAGC CTGGCACCGT GCACATCTGG AAACTGCTCT 780 TGGAGCTCCT CTCCTAGGCT GGAGCTCTCC TGCTTGCCAC CTGCCTGTCA AGACCATAGT 840 TGTACTGCTG CTGCTTCATT GCCAGACTGG GCCTGGGGCA AGAGCCACAT GGCAGCATTT 900 CCCTTTTCCC CTCCTTTGCC TTTCAAGAGC AGGGCCTGGG CAAGGCCAAG AACCATGCAG 960 AAGCCTTCCT GGTGAGGTGG CCGTGAAGCC GAAGCAGGGA GGTGGGTGAG ACAGAGGGTG 1020 GGGAGGATAG TGTCTGGCTC ATTCCAGGCT GGAATGTGGA TCCAGCTTTC CCTTCTCTTA 1080 CCTGTACAGT GAGATGCTCA GTGGGCTCAA TCCTCCACTA CAGGTCCCGG TACCTGAGGA 1140 ACCAGTGTAG GTGTCAGAAA TACTCCTAGA GCCTCAAGGT CTCCCAGTCC AGAAACAGTC 1200 TGGTGACGTC ATGCCCTTCT CATGTGGGCA GCTTCTGAGT GGTGACACAG CAAGCCTTTG 1260 TTCCTGTCCT GCATTGTCCA GCCCCAGCTC CACCTAAGTG ACTTGTGGCC TTGTGCAATC 1320 TCTGCCTCTC TGACCCCAGG GCCATTATTT TTAAAGGGAG GTGGTTTCCT AATTCGGAGA 1380 TGCCTTTCCC AGCCATGGGA GTGTGAAGTG CTAGGATGAA CCTGGCCATC CTAGCAAGGA 1440 GCTTTCTGAA GACCTCCCTG CCTTTCCCTG AGCCCAGGCC TGGCCCGCCA GCCTCTCTTG 1500 ACTACAGAAT AACTGATATT CACCCACCAA ACAGAAAAAG TGAAGGCTGG GTTTTTCCCC 1560 TCTAATCTGG AGGCAAGCTG CTGCTCTCGT ACTAACTGTG CCAGTGCCCA TGTTTACAGA 1620 AGTCAGGGGA AGGAAGGAGC CTGTGTCCCT GGGACGACAG TCAACTGGAG CTAGGTGTTG 1680 ACCTCAGAAC TGCATTTTAT TTATTAATTT ATAAGCAGAA CAGGCCAGAG TTCTAGGCTC 1740 TGTTTCTAGG TGCTGTTTTC AAAACCCCAG ATGACAGTCA TAGAAAATTT GGAACTTAGG 1800 AAAATAGCTG GAATCATGAA TGACAATGAG ATAACATACA GATGTCAGTG GAGACAAAGT 1860 TGTGGGTTCC TCCTCCCACC TGGCTTTGAG GCTGTCGTCG ATATCATAGT ACTTTACATG 1920 GATTCACATG AACTGAAACG CCACCACTTG GCCCAGGATG TTGAAAGGGT GCAAATTCCT 1980 TCTGGGTAGA TAAGAAATGA CTCTGGGAGA GGATTTCCCT TATGTGAATC TAGGTAAAAA 2040 GATGAAAAAA AATTGTATTA TGTGATCCTA AGGACAGGAA TAGCAGACCA GCCAACGGGA 2100 TGGCCTTGGG TACATCACTC AGCCTTTCTG GACCCAATTT TTCCCCAGTG AAAGCCAAGT 2160 TGGACTGAAT TTCTGGAGTT CTCATCAGTG CACATTCCAT AGTTCTCCAG TGCTTGGCGA 2220 TCAGCCCAAT TGAAGGACTG GCTCTGTACT GACACTTATT ATCGGTACAG GCAAAGAGGA 2280 GCCTGTTGTC TGTTAGGGAC CACTAAATCA ACAACCACAA ATGGATTTTT TTTTTAAGAG 2340 GAGCTGTGCA CCTCAATTTG CTGTCTAGTT GAGAATAGAG ATTGTGTGCC TTCATTTCAT 2400 TTTCATTGCT TTGTAGTATT TTATTGTATG CATGTACCAT AATTTATTTA TCCAGTTGGA 2460 ATTTATCCTG GCAAAGATTT GCAGTAAGTC TCCAGCTGAA TTTCTTTTCA GGCGACTAGC 2520 CAGTTGCACC AACAATATTT AGTGAGTAAT CCGTCTTTTC TCCACTAATG TAAATGCCAC 2580 TTTTATTATT TATTAAATGA CCTTAAATAT TGTGGTCTAC TTCCAGACTT GCTCTTCTGC 2640 TCCATTCATC TTTCTATTTC TGAATTTGCA ATGAACAGTT TATTATTGTC ACTTTATAAT 2700 ACACTTTAAG ATCTGGCAGA GTTTGTCTCC CGCATTTCTC TTTCTTTTTC AGAACTTTTC 2760 TTGATTTCCC TGCATGATCT TTGGAATCAG CTTGTCAAGA TCCAAAATAA TCCTGTTGGT 2820 ATGTTTGTTT GTATCCCATT AAAATTATAG ATGAAAAG 2858 Seq ID NO : 147 DNA Sequence Nucleic Acid Accession # : NM 021077. 1 Coding sequence : 37.. 402 1 11 21 31 41 51 CGCGCGCCCG AACGAAGCCG CGGCCCGGGC ACAGCCATGG CCCGGCGGGC GGGGGGCGCT 60 CGGATGTTCG GCAGCCTCCT GCTCTTCGCC CTGCTCGCTG CCGGCGTCGC CCCGCTCAGC 120 TGGGATCTCC CGGAGCCCCG CAGCCGAGCC AGCAAGATCC GAGTGCACTC GCGAGGCAAC 180 CTCTGGGCCA CCGGTCACTT CATGGGCAAG AAGAGTCTGG AGCCTTCCAG CCCATCCCAT 240 TGGGGACAGC TCCCCACACC TCCCCTGAGG GACCAGCGAC TGCAGCTGAG TCATGATCTG 300 CTCGGAATCC TCCTGCTAAA GAAGGCTCTG GGCGTGAGCC TCAGCCGCCC CGCACCCCAA 360 ATCCAGTACA GGAGGCTGCT GGTACAAATA CTGCAGAAAT GACACCAATA ATAGGGGCAG 420 ACACAACAGC GTGGCTTAGA TTGTGCCCAC CCAGGGAAGG TGCTGAATGG GACCCTGTTG 480 ATGGCCCCAT CTGGATGTAA ATCCTGAGCT CAAATCTCTG TTACTCCATT ACTGTGATTT 540 CTGGCTGGGT CACCAGAAAT ATCGCTGATG CAGACACAGA TTATGTTCCT GCTGTATTTC 600 CTGCTTCCCT GTTGAATTGG TGAATAAAAC CTTGCTCTT 639 Seq ID NO : 148 DNA Sequence Nucleic Acid Accession # : NM 002055. 1 Coding sequence : 15.. 1313 1 11 21 31 41 51 AGAGCCAGAG CAGGATGGAG AGGAGACGCA TCACCTCCGC TGCTCGCCGC TCCTACGTCT 60 CCTCAGGGGA GATGATGGTG GGGGGCCTGG CTCCTGGCCG CCGTCTGGGT CCTGGCACCC 120 GCCTCTCCCT GGCTCGAATG CCCCCTCCAC TCCCGACCCG GGTGGATTTC TCCCTGGCTG 180 GGGCACTCAA TGCTGGCTTC AAGGAGACCC GGGCCAGTGA GCGGGCAGAG ATGATGGAGC 240 TCAATGACCG CTTTGCCAGC TACATCGAGA AGGTTCGCTT CCTGGAACAG CAAAACAAGG 300 CGCTGGCTGC TGAGCTGAAC CAGCTGCGGG CCAAGGAGCC CACCAAGCTG GCAGACGTCT 360

ACCAGGCTGA GCTGCGAGAG CTGCGGCTGC GGCTCGATCA ACTCACCGCC AACAGCGCCC 420 GGCTGGAGGT TGAGAGGGAC AATCTGGCAC AGGACCTGGC CACTGTGAGG CAGAAGCTCC 480 AGGATGAAAC CAACCTGAGG CTGGAAGCCG AGAACAACCT GGCTGCCTAT AGACAGGAAG 540 CAGATGAAGC CACCCTGGCC CGTCTGGATC TGGAGAGGAA GATTGAGTCG CTGGAGGAGG 600 AGATCCGGTT CTTGAGGAAG ATCCACGAGG AGGAGGTTCG GGAACTCCAG GAGCAGCTGG 660 CCCGACAGCA GGTCCATGTG GAGCTTGACG TGGCCAAGCC AGACCTCACC GCAGCCCTGA 720 AAGAGATCCG CACGCAGTAT GAGGCAATGG CGTCCAGCAA CATGCATGAA GCCGAAGAGT 780 GGTACCGCTC CAAGTTTGCA GACCTGACAG ACGCTGCTGC CCGCAACGCG GAGCTGCTCC 840 GCCAGGCCAA GCACGAAGCC AACGACTACC GGCGCCAGTT GCAGTCCTTG ACCTGCGACC 900 TGGAGTCTCT GCGCGGCACG AACGAGTCCC TGGAGAGGCA GATGCGCGAG CAGGAGGAGC 960 GGCACGTGCG GGAGGCGGCC AGTTATCAGG AGGCGCTGGC GCGGCTGGAG GAAGAGGGGC 1020 AGAGCCTCAA GGACGAGATG GCCCGCCACT TGCAGGAGTA CCAGGACCTG CTCAATGTCA 1080 AGCTGGCCCT GGACATCGAG ATCGCCACCT ACAGGAAGCT GCTAGAGGGC GAGGAGAACC 1140 GGATCACCAT TCCCGTGCAG ACCTTCTCCA ACCTGCAGAT TCGAGAAACC AGCCTGGACA 1200 CCAAGTCTGT GTCAGAAGGC CACCTCAAGA GGAACATCGT GGTGAAGACC GTGGAGATGC 1260 GGGATGGAGA GGTCATTAAG GAGTCCAAGC AGGAGCACAA GGATGTGATG TGAGGCAGGA 1320 CCCACCTGGT GGCCTCTGCC CCGTCTCATG AGGGGCCCGA GCAGAAGCAG GATAGTTGCT 1380 CCGCCTCTGC TGGCACATTT CCCCAGACCT GAGCTCCCCA CCACCCCAGC TGCTCCCCTC 1440 CCTCCTCTGT CCCTAGGTCA GCTTGCTGCC CTAGGCTCCG TCAGTATCAG GCCTGCCAGA 1500 CGGCACCCAC CCAGCACCCA GCAACTCCAA CTAACAAGAA ACTCACCCCC AAGGGCAGTC 1560 TGGAGGGGCA TGGCCAGCAG CTTGCGTTAG AATGAGGAGG AAGGAGAGAA GGGGAGGAGG 1620 GCGGGGGGCA CCTACTACAT CGCCCTCCAC ATCCCTGATT CCTGTTGTTA TGGAAACTGT 1680 TGCCAGAGAT GGAGGTTCTC TCGGAGTATC TGGGAACTGT GCCTTTGAGT TTCCTCAGGC 1740 TGCTGGAGGA AAACTGAGAC TCAGACAGGA AAGGGAAGGC CCCACAGACA AGGTAGCCCT 1800 GGCCAGAGGC TTGTTTTGTC TTTTGGTTTT TATGAGGTGG GATATCCCTA TGCTGCCTAG 1860 GCTGACCTTG AACTCCTGGG CTCAAGCAGT CTACCCACCT CAGCCTCCTG TGTAGCTGGG 1920 ATTATAGATT GGAGCCACCA TGCCCAGCTC AGAGGGTTGT TCTCCTAGAC TGACCCTGAT 1980 CAGTCTAAGA TGGGTGGGGA CGTCCTGCCA CCTGGGGCAG TCACCTGCCC AGATCCCAGA 2040 AGGACCTCCT GAGCGATGAC TCAAGTGTCT CAGTCCACCT GAGCTGCCAT CCAGGGATGC 2100 CATCTGTGGG CACGCTGTGG GCAGGTGGGA GCTTGATTCT CAGCACTTGG GGGATCTGTT 2160 GTGTACGTGG AGAGGGATGA GGTGCTGGGA GGGATAGAGG GGGGCTGCCT GGCCCCCAGC 2220 TGTGGGTACA GAGAGGTCAA GCCCAGGAGG ACTGCCCCGT GCAGACTGGA GGGGACGCTG 2280 GTAGAGATGG AGGAGGAGGC AATTGGGATG GCACTAGGCA TACAAGTAGG GGTTGTGGGT 2340 GACCAGTTGC ACTTGGCCTC TGGATTGTGG GAATTAAGGA AGTGACTCAT CCTCTTGAAG 2400 ATGCTGAAAC AGGAGAGAAA GGGGATGTAT CCATGGGGGC AGGGCATGAC TTTGTCCCAT 2460 TTCTAAAGGC CTCTTCCTTG CTGTGTCATA CCAGGCCGCC CCAGCCTCTG AGCCCCTGGG 2520 ACTGCTGCTT CTTAACCCCA GTAAGCCACT GCCACACGTC TGACCCTCTC CACCCCATAG 2580 TGACCGGCTG CTTTTCCCTA AGCCAAGGGC TCTTGCGGTC CCTTCTTACT CACACACAAA 2640 ATGTACCCAG TATTCTAGGT AGTGCCCTAT TTTACAATTG TAAAACTGAG GCACGAGCAA 2700 AGTGAAGACA CTGGCTCATA TTCCTGCAGC CTGGAGGCCG GGTGCTCAGG GCTGACACGT 2760 CCACCCCAGT GCACCCACTC TGCTTTGACT GAGCAGACTG GTGAGCAGAC TGGTGGGATC 2820 TGTGCCCAGA GATGGGACTG GGAGGGCCCA CTTCAGGGTT CTCCTCTCCC CTCTAAGGCC 2880 GAAGAAGGGT CCTTCCCTCT CCCCAAGACT TGGTGTCCTT TCCCTCCACT TCTTCCTGCC 2940 ACCTGCTGCT GCTGCTGCTG CTAATCTTCA GGGCACTGCT GCTGCCTTTA GTCGCTGAGG 3000 AAAAATAAAG ACAAATGCTG CGCCCTTAAA AAA 3033 Seq ID NO : 149 DNA Sequence Nucleic Acid Accession # : L29126. 1 Coding sequence : 445.. 1845 1 11 21 31 41 51 GAATTCCGCC TCACAGTGGC CAGGTCCTGT GCCAGATTGT CCCTCTCAAC CTCCAGCCGG 60 GCGCTGTTGG CGTGAGTTGA TCGAGCCGCA GCCGCAGCTC TCGCAGCTCA GCCTGGTAGA 120 CGTCTGCCAG CTTGGTGGGC TCCTTGGCCC GCAGCTGGTT CAGCCTCAGC AGCCAGCGCC 180 TTGTTTTGCT GTTCCAGGAA GCGAACCTTC TCGATGTAGC TGGCAAAGCG GTATTGAGCT 240 CCATCATCTC TGCCCGCTCA CTGGCCCGGG TCTCCTTGAA GCCAGCATTG AGTGCCCCAG 300 CCAGGGAGAA ATCCACCCGG GTCGGAGTGG AGGGGGCATT CGAGCCAGGG AGAGGCGGGT 360 GCAGGACCCA GACGGCGGCC AGGAGCCAGG CCCCCCACCA TCATCTCCCC TGAGGAGACG 420 TAGGAGCGGC GAGCAGCGGA GGTGATGCGT CTCCTCTCCA GCCTGTCCGG CTCGTCGGTG 480 TCCTCCGATG CTGAAGAATA CCAGCCTCCT ATATGGAAAT CATACTTATA TCAGTTACAG 540 CAAGAGGCAC CTCGTCCCAA GAGAATCATT TGTCCTCGGG AGGTGGAAAA CAGACCAAAA 600 TATTATGGAA GAGAGTTTCA TGGGATCATC TCTCGGGAGC AGGCGGATGA GCTTCTTGGA 660 GGCGTGGAGG GTGCCTACAT CCTTAGAGAA AGCCAGCGGC AACCAGGATG CTACACGCTG 720 GCTCTCAGGT TTGGAAACCA GACCTTAAAC TACAGGCTCT TCCACGACGG GAAACACTTT 780 GTGGGTGAGA AGAGGTTTGA GTCGATTCAT GATCTGGTGA CAGATGGCTT GATAACACTG 840 TACATAGAAA CAAAAGCTGC CGAGTACATT TCAAAAATGA CAACTAACCC CATCTATGAA 900 CACATTGGAT ATGCCACCCT ACTCAGAGAA AAAGTATCCA GAAGGCTGAG CAGGTCTAAA 960 AATGAACCAA GAAAAACAAA CGTCACACAT GAAGAACACA CAGCGGTGGA AAAGATCTCC 1020 TCCCTGGTTC GAAGGGCTGC CCTCACACAC AACGACAACC ACTTCAATTA TGAGAAGACA 1080 CACAACTTTA AGGTCCACAC GTTCCGAGGC CCACACTGGT GTGAATATTG TGCCAATTTC 1140 ATGTGGGGGC TCATCGCCCA AGGGGTCCGG TGCTCAGACT GTGGATTGAA CGTACACAAA 1200 CAGTGTTCCA AGCACGTTCC CAATGACTGC CAACCTGATC TCAAGAGGAT CAAGAAAGTG 1260 TACTGTTGTG ACCTCACAAC ACTTGTGAAG GCTCACAACA CTCAGAGACC CATGGTGGTA 1320 GACATATGCA TTCGGGAAAT TGAAGCAAGA GGATTAAAAT CGGAAGGCCT TTACAGAGTC 1380 TCTGGGTTCA CTGAACACAT TGAAGATGTC AAAATGGCAT TTGACAGAGA TGGTGAAAAG 1440 GCCGATATAT CTGCCAATGT CTATCCAGAC ATAAACATCA TCACTGGAGC CCTTAAACTG 1500 TATTTCAGAG ACTTACCCAT CCCTGTCATC ACATATGATA CCTATTCCAA ATTTATAGAT 1560 GCAGCAAAAA TCTCCAATGC AGATGAGAGG CTGGAAGCCG TCCATGAAGT GCTGATGCTG 1620 CTGCCTCCTG CCCACTATGA AACCCTCCGG TACCTAATGA TCCACCTCAA AAAGGTTACT 1680 ATGAATGAAA AAGACAATTT CATGAATGCA GAAAATCTGG GGATCGTGTT TGGGCCCACT 1740 CTGATGAGGC CCCCTGAGGA CAGCACCCTG ACCACCCTGC ATGATATGCG GTACCAAAAG 1800 CTGATTGTGC AGATTTTAAT AGAAAACGAA GACGTTTTAT TCTAATCCAT CAGGGAAATG 1860 AGCTGAATGG CCCAGCACCA TCAAGTTGAC ACAGCTAAGG ATAAAACATT TCTTACCACT 1920 TGATTTGTTT TCCAAGCAAG TGCTAGAATT TGCTGGACTG CAGAGGATCG CTGAGTGGGG 1980

TACTGTGTCT CATAGACATG CGCCACCTCC ACGTGAGAAC AAGGGTGAAG GTGAGGGAAG 2040 CCCCTCAGGT TGGGTCTTTT GCTGTGCCTC CTATGTATGT CTGGTTTGCT GGAAGAGTGA 2100 TTAATACATC TTTAATTTAT TAAAAAACAA TGTAGACCTT TAAACTTCAG TCTTATTGGG 2160 AATAAAAGGG AACTTAATTC ATACAGGTAC TTGATACAGT TATACATTTT CCACTTACAA 2220 AAAGAAGACA ATTCTGTTAA ATGAAACGTG TATCGTAAAA TGTAATTTTA TTTACCCACG 2280 AGAATGTTGT TATTTTAGCA ATAGAACTCA ATGCAGATGC ATTGGTTATT ACCCTGTGTA 2340 CCTTGTCCCT CATTTTGCTG TGACACCCTG AAAAAGCTGA CCACAAATGC AGTATTATCA 2400 TTGACATACC TCTGTCCTCC TCAGTGCTTT TTAATGTAAT TTCACCGGAA TTC 2453 Seq ID NO : 150 DNA Sequence Nucleic Acid Accession # : XM _113553. 1 Coding sequence : 25.. 939 1 11 21 31 41 51 CCCAGGAACC CCCAGGGAGC CAGCATGAAG CGAGCTCACC CCGAGTACAG CTCCTCGGAC 60 AGCGAGCTGG ACGAGACCAT CGAGGTGGAG AAGGAGAGTG CGGACGAGAA TGGAAACTTG 120 AGTTCGGCTC TAGGTTCCAT GTCCCCAACT ACATCTTCCC AGATTTTGGC CAGAAAAAGA 180 CGGAGAGGAA TAATTGAGAA GCGCCGACGA GACCGGATCA ATAACAGTTT GTCTGAGCTG 240 AGAAGGCTGG TACCCAGTGC TTTTGAGAAG CAGGGATCTG CTAAGCTAGA AAAAGCCGAG 300 ATCCTGCAGA TGACCGTGGA TCACCTGAAA ATGCTGCATA CGGCAGGAGG GAAAGGTTAC 360 TTTGACGCGC ACGCCCTTGC TATGGACTAT CGGAGTTTGG GATTTCGGGA ATGCCTGGCA 420 GAAGTTGCGC GTTATCTGAG CATCATTGAA GGACTAGATG CCTCTGACCC GCTTCGAGTT 480 CGACTGGTTT CGCATCTCAA CAACTACGCT TCCCAGCGGG AAGCCGCGAG CGGCGCCCAC 540 GCGGGCCTCG GACACATTCC CTGGGGGACC GTCTTCGGAC ATCACCCGCA CATCGCGCAC 600 CCGCTGTTGC TGCCCCAGAA CGGCCACGGG AACGCGGGCA CCACGGCCTC ACCCACGGAA 660 CCGCACCACC AGGGCAGGCT GGGCTCGGCA CATCCGGAGG CGCCTGCTTT GCGAGCGCCC 720 CCTAGCGGCA GCCTCGGACC GGTGCTCCCT GTGGTCACCT CCGCCTCCAA ACTGTCGCCG 780 CCTCTGCTCT CCTCAGTGGC CTCCCTGTCG GCCTTCCCCT TCTCTTTCGG CTCCTTCCAC 840 TTACTGTCTC CCAATGCACT GAGCCCTTCA GCACCCACGC AGGCTGCAAA CCTTGGCAAG 900 CCCTATAGAC CTTGGGGGAC GGAGATCGGA GCTTTTTAAA GAACTGATGT AGAATGAGGG 960 AGGGGAAAGT TTAAAATCCC AGCTGGGCTG GACTGTTGCC AACATCACCT TAAAGTCGTC 1020 AGTAAAAGTA AAAAGGAAAA AGGTACACTT TCAGATAATT TTTTTTTTAA AGACTAAAGG 1080 TTTGTTGGTT TACTTTTATC TTTTTTAATG TTTTTTTCAT CATGTCATGT ATTAGCAGTT 1140 TTTAAAAACT AGTTGTTAAA TTTTGTTCAA GACATTAAAT TGAAATAGTG AGTATAAGCC 1200 AACACTTTGT GATAGGTTTG TACTGTGCCT AATTTACTTT GTAAACCAGA ATGATTCCGT 1260 TTTTGCCTCA AAATTTGGGG AATCTTAACA TTTAGTATTT TTGGTCTGTT TTTCTCCTTG 1320 TATAGTTATG GTCTGTTTTT AGAATTAATT TTCCAAACCA CTATGCTTAA TGTTAACATG 1380 ATTCTGTTTG TTAATATTTT GACAGATTAA GGTGTTGTAT AAATAATATT CTTTTGGGGG 1440 GAGGGGAACT ATATTGAATT TTATATTTCT GAGCAAAGCG TTGACAAATC AGATGATCAG 1500 CTTTATCCAA GAAAGAAGAC TAGTAAATTG TCTGCCTCCT ATAGCAGAAA GGTGAATGTA 1560 CAAACTGTTG GTGGCCCTGA ATCCATCTGA CCAGCTGCTG GTATCTGCCA GGACTGGCAG 1620 TTCTGATTTA GTTAGGAGAG AGCCGCTGAT AGGTTAGGTC TCATTTGGAG TGTTGGTGGA 1680 AAGGAAACTG AAGGTAATTG AATAGAATAC GCCTGCATTT ACCAGCCCCA GCAACACAAA 1740 GAATTTTTAA TCACACGGAT CTCAAATTCA CAAATGTTAA CATGGATAAG TGATCATGGT 1800 GTGCGAGTGG TCAATTGAGT AGTACAGTGG AAACTGTTAA ATGCATAACC TAATTTTCCT 1860 GGGACTGCCA TATTTTCTTT TAACTGGAAA TTTTTATGTG AGTTTTCCTT TTGGTGCATG 1920 GAACTGTGGT TGCCAAGGTA TTTAAAAGGG CTTTCCTGCC TCCTTCTCTT TGATTTATTT 1980 AATTTGATTT GGGCTATAAA ATATCATTTT TCAGGTTTAT TCTTTTAGCA GGTGTAGTTA 2040 AACGACCTCC ACTGAACTGG GTTTGACCTC TGTTGTACTG ATGTGTTGTG ACTAAATAAA 2100 AAA 2103 Seq ID NO : 151 DNA Sequence Nucleic Acid Accession # : NM 001936. 2 Coding sequence : 178.. 2589 1 11 21 31 41 51 AGCAAACTCG TCTTGTCTAC CCACCCTCCC TCCCCCATCC TCCCCAAAAT AGCCTTGTGA 60 TTTCGGAAGT ATGGACTAAA ATCACACTCC TCCTTACCTT ACCGCTTGGA CTCTGGTGGC 120 TCCCAACTCG CCGTCAGACC CCACCTGCCC CGGTGGTGGG AAGCGCCTGG ACAGACCATG 180 ACCACAGCCA AGGAGCCAAG CGCTTCGGGG AAATCCGTGC AGCAGCAGGA ACAGGAGCTG 240 GTGGGGAGTA ACCCTCCGCA GAGGAATTGG AAAGGAATAG CAATTGCACT GCTTGTCATT 300 CTGGTCATCT GCTCCTTGAT CGTCACCTCG GTCATACTTC TGACACCAGC GGAAGATAAT 360 AGTCTGTCTC AAAAGAAGAA GGTCACTGTA GAAGATCTCT TCAGTGAAGA CTTCAAAATT 420 CATGACCCCG AGGCTAAGTG GATAAGTGAT ACAGAATTCA TCTACAGAGA ACAGAAAGGA 480 ACAGTGAGAC TGTGGAATGT TGAAACAAAT ACTTCTACTG TCTTAATAGA AGGCAAAAAA 540 ATTGAATCAT TAAGAGCCAT CAGATATGAA ATATCTCCAG ATAGAGAGTA TGCACTTTTT 600 TCATACAATG TGGAACCCAT ATATCAACAC TCGTATACTG GATATTACGT CCTGAGCAAA 660 ATTCCTCATG GGGATCCTCA AAGTCTGGAC CCACCAGAAG TCAGCAATGC AAAGCTTCAG 720 TATGCAGGAT GGGGCCCTAA AGGCCAACAG CTGATATTTA TTTTTGAAAA CAATATCTAC 780 TACTGTGCAC ATGTCGGGAA ACAGGCCATC CGTGTGGTCT CCACTGGCAA GGAAGGTGTG 840 ATTTACAATG GCCTCAGTGA CTGGCTGTAT GAAGAGGAGA TTTTGAAGAC ACACATCGCA 900 CACTGGTGGT CTCCGGATGG CACGAGACTC GCCTACGCCG CCATCAATGA TTCCCGTGTC 960 CCCATCATGG AGCTCCCAAC TTACACCGGC TCCATCTACC CCACCGTGAA GCCCTACCAC 1020 TATCCCAAGG CTGGAAGTGA GAACCCCAGC ATTTCCCTAC ACGTTATTGG CTTAAATGGA 1080 CCCACCCATG ATCTGGAGAT GATGCCGCCT GATGATCCAC GGATGAGGGA GTACTACATC 1140 ACCATGGTGA AGTGGGCCAC CAGCACCAAG GTCGCCGTGA CCTGGCTGAA CCGGGCGCAG 1200 AACGTGTCCA TCCTCACCCT CTGCGACGCC ACCACGGGGG TCTGCACGAA GAAACACGAG 1260 GATGAAAGTG AGGCCTGGCT CCACAGACAG AATGAAGAAC CTGTGTTCTC CAAGGATGGC 1320 CGAAAGTTTT TCTTCATCAG AGCCATCCCC CAGGGAGGAC GAGGGAAATT CTATCACATC 1380 ACGGTGTCCT CGTCCCAGCC CAACAGCAGC AACGACAACA TCCAGTCCAT CACCTCCGGG 1440 GACTGGGACG TGACCAAGAT CCTAGCCTAC GATGAGAAGG GGAATAAGAT CTACTTCCTG 1500 AGCACGGAGG ACCTGCCTCG GAGACGACAA CTCTACAGTG CCAACACGGT GGGCAACTTC 1560 AACAGGCAGT GCCTCTCCTG TGACCTGGTT GAGAACTGCA CCTACTTCAG CGCTTCCTTC 1620 AGCCATAGCA TGGACTTCTT CCTGCTCAAG TGCGAAGGTC CTGGTGTTCC TATGGTGACG 1680

GTGCACAACA CAACAGATAA GAAAAAAATG TTTGACCTAG AAACAAATGA ACATGTCAAG 1740 AAGGCCATAA ATGACCGACA GATGCCTAAA GTGGAATACA GGGACATTGA GATTGATGAT 1800 TACAACCTGC CCATGCAGAT ACTGAAGCCA GCAACCTTCA CCGACACCAC CCACTACCCT 1860 CTGCTCCTGG TGGTGGATGG CACCCCGGGC AGCCAGAGTG TAGCTGAGAA GTTCGAGGTG 1920 AGCTGGGAGA CGGTGATGGT GAGCAGCCAC GGCGCGGTGG TGGTAAAGTG TGACGGCCGT 1980 GGCAGCGGCT TCCAAGGGAC CAAGCTCCTG CACGAAGTGA GGCGGCGGCT GGGCTTGCTG 2040 GAGGAGAAGG ACCAGATGGA GGCCGTGCGG ACGATGCTGA AGGAGCAGTA CATTGACAGG 2100 ACGCGCGTGG CCGTGTTTGG GAAGGATTAC GGTGGCTACC TGAGCACCTA CATCCTCCCA 2160 GCAAAGGGAG AAAATCAAGG CCAGACATTC ACCTGCGGCT CTGCTCTCTC TCCAATAACA 2220 GACTTCAAAC TCTATGCCTC TGCGTTTTCC GAGAGGTACT TGGGCCTCCA TGGACTTGAC 2280 AACAGAGCAT ACGAGATGAC CAAGGTAGCC CATCGAGTCT CCGCGCTGGA AGAACAGCAG 2340 TTCCTGATCA TTCATCCCAC TGCCGATGAA AAAATTCATT TCCAGCACAC AGCAGAACTC 2400 ATTACACAAC TAATTAGGGG AAAGGCTAAT TACAGCTTAC AGATTTACCC GGACGAAAGC 2460 CATTACTTTA CCAGCTCCAG CCTCAAACAG CATCTGTACC GGTCCATCAT CAACTTCTTC 2520 GTGGAATGCT TCAGGATCCA GGACAAACTG CCGACAGTCA CAGCGAAAGA GGACGAGGAG 2580 GAGGACTAAG CTCAGGTCGC TCTAAGCACA AACGTGGCTC TTTCTACAAC CAGATGCAAC 2640 CGAGGGATTT CCCTGCCCTC CCTCTTCCCT CGGAGGGGCG GGGCGGGGCG GGGCCGGGTG 2700 TTCCATAGCA TGTGTGTCTC GGATGCGGAA GGCAGTTTTG CTTGGGAAAC AAGCTCCTTC 2760 CCCGGGGTCA TCACTCACGG CCTCCATGGC ACCAGGGACA ACGCTGTCCC CGCAGCAGCG 2820 CCTCCTCCCG GCGCCCGAGA GACCGGCACG CCACGGCCCC TCCCCCAAGG AACAGAGCAA 2880 AGGATGGTGG CCGCAGGCCC CACGCGAGCC CACAGGACAC CGGCCCCTAG ATTCCAGCCA 2940 CCAAGCGGAA GCATGAGACC CGCCCACACT AGCCTCTGTG TTCCCGTTAG GGACATCACA 3000 CCCTGTCTCA CGTCGCAGTG CCATGGACGC AGCAGTTACA GCACCATTGT TTTAGCAGTG 3060 CGTGTTCATA TATGGGCTTG CTACTTCCTG TAATGAGGAC GTTCAACATG GTGAGGGGCT 3120 ACAAGAAAAC GCTTTTCTGT ACAGAGTCTT ACTGTAGCTA CGCTAATGGT TAACCTGATA 3180 GAATTAACTC GTATTTTTCT ATGGTTTTAA CCTGATGCTC CACTGTCTCC GTCATGGGGT 3240 TGTTTTGCTG TTTGGGGTTG GGCCTTGTTT CCCTTTCCTT TCTCCAGTCC ACGTGTAGAC 3300 TTTGCGCTTG ATGAAGAAGC AGATCGGAAG TAACTGCTCC CTCCTCAAGG TTGTCTTCAG 3360 ACGTCTTGGG GACGTTCCTA AACACTGAGG GGGAAGACAG CCAATAGCAC CCATTAAAAG 3420 AAATACCTAA ATAAAACCTC TCTCCCACTC AGCTATGCTA GGGCTTGGCT GTAGGTGTGC 3480 ACTGTCTATT TACATCCGTC CTTACAACCA TCCTTGTCCT CCTTGGTACC GTATCAAGCT 3540 CTTTCCCATG ACATTTGGTT 3560 Seq ID NO : 152 DNA Sequence Nucleic Acid Accession # : XM087461. 1 Coding sequence : 236.. 1138 1 11 21 31 41 51 CCGGCGCCGG GGGCGGCGGG GAACCCCAAA CGCAACCGGG TCTGGAGGGA TCCCCGCGCC 60 GAGCCAGCCG CCGTCACCGC CTCCGCGCCG CCCCTGCGGG CTTGGCAGGC GCCCGGCGCG 120 CCCGCACTGC GCCCGGCCGC CGGCTCCCGC GGTCCCACCG TGAGCTCGCC GGCCCGTCGC 180 CCGCTCGCCA TGCAACCGCC GCCGGCCTCG CGCGCGTAGG CGCCCGCCGC AGGCCATGCT 240 GCCCCTGCTC GCCGCGCTCC TGGCCGCCGC CTGCCCGCTG CCGCCCGTCC GCGGCGGGGC 300 CGCGGACGCG CCCGGCCTCC TCGGGGTGCC CTCCAATGCT TCAGTCAACG CGTCCTCCGC 360 GGCGAGCCCA TCGCCCCGCG GCTGCTGGCC TCGGCGGCCC CCGGGCCCCC CGAGCGCCCG 420 GGCCCGGAGG AGGCGGCGGC GGCGGCGGCG CCTGTGCAAC ATCAGCGTGC AGCGGCAGAT 480 GCTGAGCTCG CTGCTCGTGC GCTGGGGCCG CCCGCGGGGC TTCCAGTGCG ACCTACTGCT 540 CTTCTCCACC AACGCGCACG GCCGCGCTTT CTTCGCCGCC GCCTTCCACC GCGTCGGGCC 600 GCCGCTGCTC ATCGAGCACC TGGGGCTGGC GGCGGGCGGC GCGCAGCAGG ACCTGCGCCT 660 CTGCGTGGGC TGCGGCTGGG TGCGCGGTCG CCGCACCGGC CGCCTCCGGC CCGCCGCCGC 720 CCCCAGCGCC GCCGCCGCCA CCGCCGGGGC GCCCACCGCG CTGCCAGCCT ACCCCGCGGC 780 CGAGCCGCCC GGGCCGCTGT GGCTGCAGGG CGAGCCGCTG CATTTCTGCT GCCTAGACTT 840 CAGCCTGGAG GAGCTGCAGG GCGAGCCGGG CTGGCGGCTG AACCGTAAGC CCATTGAGTC 900 CACGCTGGTG GCCTGCTTCA TGACCCTGGT CATCGTGGTG TGGAGCGTGG CCGCCCTCAT 960 CTGGCCGGTG CCCATCATCG CCGGCTTCCT GCCCAACGGC ATGGAACAGC GCCGGACCAC 1020 CGCCAGCACC ACCGCAGCCA CCCCCGCCGC AGTGCCCGCA GGGACCACCG CAGCCGCCGC 1080 CGCCGCCGCC GCTGCCGCCG CCGCCGCGGC CGTCACTTCG GGGGTGGCGA CCAAGTGACC 1140 CGCTCCGCTC CTCCCTGTGT CCGTCCTGTG TCCGCGCGCG CGGGTGCCTT TCCCGCCGGA 1200 GACTCGGCCG GTGTGCTTCG TGCTGTAGTT ATCGTTAGTT CCTCTTCCCG AGATGGGGCC 1260 GCCGAGAGAC CCCAGCGCCT TTGAAAAGCA AGGTTTGTGC TGCGCTTCCA GTTCCGAAAA 1320 GCAGATGTTT AAGCCCTTGG ACTGAGGGTG GGATCGCAGC TCCGAAGACG GAGAGGAGGG 1380 AAATGGGGCC CTTTCCCCTC TATTGCATCC CCCTGCCCGA CTCCTTCCCC GCACCCACGT 1440 GCCCTAGATT CATGGCAGAA AATGACCAAA TCCTGTGTAT TTGTTTTATA TATTTAATAA 1500 CTGTTTTAAA TGAAAGTTTT AGTAAAAAAA ATACAAAACA AAAAGATTAA ATTGCTATTG 1560 CTGTAGTAAG AGAAGCTCTT TGTATCTGAA CATAGTTGTA TTTGAAATTT GTGGTTTTTT 1620 AATTTATTTA AAATTGGGGG GAGGGCATGG GAAGGATTTA ACACCGATAT ATTGTTACCG 1680 CTGAAAATGA ACTTTATGAA CCTTTTCCAA GTTGATCTAT CCAGTGACGT GGCCTGGTGG 1740 GCGTTTCTTC TTGTACTTAT GTGGTTTTTT GGCTTTTAAT ACAGACATTT TCCTCC 1796 Seq ID NO : 153 DNA Sequence Nucleic Acid Accession N : Nom 012261. 1 Coding sequence : 1-843 1 11 21 31 41 51 1 1 1 1 1 1 ATGGATCTCC AAGGAAGAGG GGTCCCCAGC ATCGACAGAC TTCGAGTTCT CCTGATGTTG 60 TTCCATACAA TGGCTCAAAT CATGGCAGAA CAAGAAGTGG AAAATCTCTC AGGCCTTTCC 120 ACTAACCCTG AAAAAGATAT ATTTGTGGTG CGGGAAAATG GGACGACGTG TCTCATGGCA 180 GAGTTTGCAG CCAAATTTAT TGTACCTTAT GATGTGTGGG CCAGCAACTA CGTAGATCTG 240 ATCACAGAAC AGGCCGATAT CGCATTGACC CGGGGAGCTG AGGTGAAGGG CCGCTGTGGC 300 CACAGCCAGT CGGAGCTGCA AGTGTTCTGG GTGGATCGCG CATATGCACT CAAAATGCTC 360 TTTGTAAAGG AAAGCCACAA CATGTCCAAG GGACCTGAGG CGACTTGGAG GCTGAGCAAA 420 GTGCAGTTTG TCTACGACTC CTCGGAGAAA ACCCACTTCA AAGACGCAGT CAGTGCTGGG 480 AAGCACACAG CCAACTCGCA CCACCTCTCT GCCTTGGTCA CCCCCGCTGG GAAGTCCTAT 540 GAGTGTCAAG CTCAACAAAC CATTTCACTG GCCTCTAGTG ATCCGCAGAA GACGGTCACC 600

ATGATCCTGT CTGCGGTCCA CATCCAACCT TTTGACATTA TCTCAGATTT TGTCTTCAGT 660 GAAGAGCATA AATGCCCAGT GGATGAGCGG GAGCAACTGG AAGAAACCTT GCCCCTGATT 720 TTGGGGCTCA TCTTGGGCCT CGTCATCATG GTAACACTCG CGATTTACCA CGTCCACCAC 780 AAAATGACTG CCAACCAGGT GCAGATCCCT CGGGACAGAT CCCAGTATAA GCACATGGGC 840 TAG 843 Seq ID NO : 154 DNA Sequence Nucleic Acid Accession # : Nom 144586 Coding sequence : 261.. 686 1 11 21 31 41 51 GGCACGAGGC CGGAGGCGCG GTGCTCGGCC CGGGAGCGCG AGCGGGAGGA GCAGAGACCC 60 GCAGCCGGGA GCCCGAGCGC GGGCGATGCA GGCTCCGCGA GCGGCACCTG CGGCTCCTCT 120 AAGCTACGAC CGTCGTCTCC GCGGCAGCAG CGCGGGCCCC AGCAGCCTCG GCAGCCACAG 180 CCGCTGCAGC CGGGGCAGCC TCCGCTGCTG TCGCCTCCTC TGATGCGCTT GCCCTCTCCC 240 GGCCCCGGGA CTCCGGGAGA ATGTGGGTCC TAGGCATCGC GGCAACTTTT TGCGGATTGT 300 TCTTGCTTCC AGGCTTTGCG CTGCAAATCC AGTGCTACCA GTGTGAAGAA TTCCAGCTGA 360 ACAACGACTG CTCCTCCCCC GAGTTCATTG TGAATTGCAC GGTGAACGTT CAAGACATGT 420 GTCAGAAAGA AGTGATGGAG CAAAGTGCCG GGATCATGTA CCGCAAGTCC TGTGCATCAT 480 CAGCGGCCTG TCTCATCGCC TCTGCCGGGT ACCAGTCCTT CTGCTCCCCA GGGAAACTGA 540 ACTCAGTTTG CATCAGCTGC TGCAACACCC CTCTTTGTAA CGGGCCAAGG CCCAAGAAAA 600 GGGGAAGTTC TGCCTCGGCC CTCAGGCCAG GGCTCCGCAC CACCATCCTG TTCCTCAAAT 660 TAGCCCTCTT CTCGGCACAC TGCTGAAGCT GAAGGAGATG CCACCCCCTC CTGCATTGTT 720 CTTCCAGCCC TCGCCCCCAA CCCCCCACCT CCCTGAGTGA GTTTCTTCTG GGTGTCCTTT 780 TATTCTGGGT AGGGAGCGGG AGTCCGTGTT CTCTTTTGTT CCTGTGCAAA TAATGAAAGA 840 GCTCGGTAAA GCATTCTGAA TAAATTCAGC CTGACTGAAT TTTCAGTATG TACTTGAAGG 900 AAGGAGGTGG AGTGAAAGTT CACCCCCAAA AAAAAAAAAA AAAAAA 946 Seq ID NO : 15S DNA Sequence Nucleic Acid Accession # : NM 004694 Coding sequence : 166.. 1737 1 11 21 31 41 51 TTGGGGGTTT ATTCTCTTCC CTTCTAACTT GACAGGGTCT TGCTCTGTCA TTCAGGCAAG 60 AGTGCAGTAG TGTGATCACT TCTTACTGCC GCCTCAAGCT TCCAGCCTCA ACTCAAGCAA 120 TCCTCCCACC TCAGCCACCC AAGTGGCTGG GACTACAGAT TAAGAATGAC CCAAAATAAA 180 TTAAAGCTTT GTTCCAAAGC CAATGTGTAT ACTGAAGTGC CTGATGGAGG ATGGGGCTGG 240 GCGGTAGCTG TTTCATTTTT CTTCGTTGAA GTCTTCACCT ACGGCATCAT CAAGACATTT 300 GGTGTCTTCT TTAATGACTT AATGGACAGT TTTAATGAAT CCAATAGCAG GATCTCATGG 360 ATAATCTCAA TCTGTGTGTT TGTCTTAACA TTTTCAGCTC CCCTCGCCAC AGTCCTGAGC 420 AATCGTTTCG GACACCGTCT GGTAGTGATG TTGGGGGGGC TACTTGTCAG CACCGGGATG 480 GTGGCCGCCT CCTTCTCACA AGAGGTTTCT CATATGTACG TCGCCATCGG CATCATCTCT 540 GGTCTGGGAT ACTGCTTTAG TTTTCTCCCA ACTGTAACCA TCCTATCACA ATATTTTGGC 600 AAAAGACGTT CCATAGTCAC TGCAGTTGCT TCCACAGGAG AATGTTTCGC TGTGTTTGCT 660 TTCGCACCAG CAATCATGGC TCTGAAGGAG CGCATTGGCT GGAGATACAG CCTCCTCTTC 720 GTGGGCCTAC TACAGTTAAA CATTGTCATC TTCGGAGCAC TGCTCAGACC CATCATTATC 780 AGAGGACCAG CGTCACCGAA AATAGTCATC CAGGAAAATC GGAAAGAAGC GCAGTATATG 840 CTTGAAAATG AGAAAACACG AACCTCAATA GACTCCATTG ACTCAGGAGT AGAACTAACT 900 ACCTCACCTA AAAATGTGCC TACTCACACT AACCTGGAAC TGGAGCCGAA GGCCGACATG 960 CAGCAGGTCC TGGTGAAGAC CAGCCCCAGG CCAAGCGAAA AGAAAGCCCC GCTATTAGAC 1020 TTCTCCATTT TGAAAGAGAA AAGTTTTATT TGTTATGCAT TATTTGGTCT CTTTGCAACA 1080 CTGGGATTCT TTGCACCTTC CTTGTACATC ATTCCTCTGG GCATTAGTCT GGGCATTGAC 1140 CAGGACCGCG CTGCTTTTTT ATTATCTACG ATGGCCATTG CAGAAGTTTT CGGAAGGATC 1200 GGAGCTGGTT TTGTCCTCAA CAGGGAGCCC ATTCGTAAGA TTTACATTGA GCTCATCTGC 1260 GTCATCTTAT TGACTGTGTC TCTGTTTGCC TTTACTTTTG CTACTGAATT CTGGGGTCTA 1320 ATGTCATGCA GCATATTTTT TGGGTTTATG GTTGGAACAA TAGGAGGACT CACATTCCAC 1380 TGCTTGCTGA AGATGATGTC GTGGGCATTG CAGAAGATGT CTTCTGCAGC TGGGGTCTAC 1440 ATCTTCATTC AGAGCATAGC AGGACTGGCT GGACCGCCCC TTGCAGGTTT GTTGGTGGAC 1500 CAAAGTAAGA TCTACAGCAG GGCCTTCTAC TCCTGCGCAG CTGGCATGGC CCTGGCTGCT 1560 GTGTGCCTCG CCCTGGTGAG ACCGTGTAAG ATGGGACTGT GCCAGCGTCA TCACTCAGGT 1620 GAAACAAAGG TAGTGAGCCA TCGTGGGAAG ACTTTACAGG ACATACCTGA AGACTTTCTG 1680 GAAATGGATC TTGCAAAAAA TGAGCACAGA GTTCACGTGC AAATGGAGCC GGTATGACAC 1740 ACTTTCTTAC AACAACAGCC ACTGTGTTGG CTGGAGAGGG ATGGGGTGGG CCCAACGGGG 1800 ACACAAGGAG GCAGAGGAGC TAACCCCTCT ACTCCACTTT CAAAACTACA TTTTAAAGGG 1860 AATGTGTATG TGAAGAGCAC TACCAACATC GCTTTTGTTT TGTTTTGTTT TGTTTTAAGC 1920 TTTTTTTTTT TGCTTGTTTT TAAAGCCAAA ACAAAAAACA ACCAAGCACT CTTCCATATA 1980 TAAATCTGGC TGTATTCAGT AGCAATACAA GAGATATGTA GAAAGACTCT TTGGTTCACA 2040 TTCCGATATT AAAATAGTGA CATGAACTGG CAAAGTGGTT TTAAAAGCTT TCACGTGGGA 2100 TAAATGATTT TCTTTTTTTC TTTTCTTTCT TCCTATGGTC TTGTCTGAAT AAACTACTCT 2160 CCTGAATAAA ACAACATCCA ACCCAGGTCA TTGAAATGAA ATTGGCCAGT C. 2212 Seq ID NO : 156 DNA Sequence Nucleic Acid Accession # : NM_004833. 1 Coding sequence : 246.. 1277 1 11 21 31 41 51 TCAGCCAATT AGAGCTCCAG TTGTCACTCC TACCCACACT GGGCCTGGGG GTGAAGGGAA 60 GTGTTTATTA GGGGTACATG TGAAGCCGTC CAGAAGTGTC AGAGTCTTTG TAGCTTTGAA 120 AGTCACCTAG GTTATTTGGG CATGCTCTCC TGAGTCCTCT GCTAGTTAAG CTCTCTGAAA 180 AGAAGGTGGC AGACCCGGTT TGCTGATCGC CCCAGGGATC AGGAGGCTGA TCCCAAAGTT 240 GTCAGATGGA GAGTAAATAC AAGGAGATAC TCTTGCTAAC AGGCCTGGAT AACATCACTG 300 ATGAGGAACT GGATAGGTTT AAGTTCTTTC TTTCAGACGA GTTTAATATT GCCACAGGCA 360 AACTACATAC TGCAAACAGA ATACAAGTAG CTACCTTGAT GATTCAAAAT GCTGGGGCGG 420 TGTCTGCAGT GATGAAGACC ATTCGTATTT TTCAGAAGTT GAATTATATG CTTTTGGCAA 480

AACGTCTTCA GGAGGAGAAG GAGAAAGTTG ATAAGCAATA CAAATCGGTA ACAAAACCAA 540 AGCCACTAAG TCAAGCTGAA ATGAGTCCTG CTGCATCTGC AGCCATCAGA AATGATGTCG 600 CAAAGCAACG TGCTGCACCA AAAGTCTCTC CTCATGTTAA GCCTGAACAG AAACAGATGG 660 TGGCCCAGCA GGAATCTATC AGAGAAGGGT TTCAGAAGCG CTGTTTGCCA GTTATGGTAC 720 TGAAAGCAAA GAAGCCCTTC ACGTTTGAGA CCCAAGAAGG CAAGCAGGAG ATGTTTCATG 780 CTACAGTGGC TACAGAAAAG GAATTCTTCT TTGTAAAAGT TTTTAATACA CTGCTGAAAG 840 ATAAATTCAT TCCAAAGAGA ATAATTATAA TAGCAAGATA TTATCGGCAC AGTGGTTTCT 900 TAGAGGTAAA TAGCGCCTCA CGTGTGTTAG ATGCTGAATC TGACCAAAAG GTTAATGTCC 960 CGCTGAACAT TATCAGAAAA GCTGGTGAAA CCCCGAAGAT CAACACG « T CAAACTCAGC 1020 CCCTTGGAAC AATTGTGAAT GGTTTGTTTG TAGTCCAGAA GGTAACAGAA AAGAAGAAAA 1080 ACATATTATT TGACCTAAGT GACAACACTG GGAAAATGGA AGTACTGGGG GTTAGAAACG 1140 AGGACACAAT GAAATGTAAG GAAGGAGATA AGGTTCGACT TACATTCTTC ACACTGTCAA 1200 AAAATGGAGA AAAACTACAG CTGACATCTG GAGTTCATAG CACCATAAAG GTTATTAAGG 1260 CCAAAAAAAA AACATAGAGA AGTAAAAAGG ACCAATTCAA GCCAACTGGT CTAAGCAGCA 1320 TTTAATTGAA GAATATGTGA TACAGCCTCT TCAATCAGAT TGTAAGTTAC CTGAAAGCTG 1380 CAGTTCACAG GCTCCTCTCT CCACCAAATT AGGATAGAAT AATTGCTGGA TAAACAAATT 1440 CAGAATATCA ACAGATGATC ACAATAAACA TCTGTTTCTC ATTCC 1485 Seq ID NO : 157 DNA Sequence Nucleic Acid Accession # : NM_005409. 3 Coding sequence : 94.. 378 1 11 21 31 41 51 TTCCTTTCAT GTTCAGCATT TCTACTCCTT CCAAGAAGAG CAGCAAAGCT GAAGTAGCAG 60 CAACAGCACC AGCAGCAACA GCAAAAAACA AACATGAGTG TGAAGGGCAT GGCTATAGCC 120 TTGGCTGTGA TATTGTGTGC TACAGTTGTT CAAGGCTTCC CCATGTTCAA AAGAGGACGC 180 TGTCTTTGCA TAGGCCCTGG GGTAAAAGCA GTGAAAGTGG CAGATATTGA GAAAGCCTCC 240 ATAATGTACC CAAGTAACAA CTGTGACAAA ATAGAAGTGA TTATTACCCT GAAAGAAAAT 300 AAAGGACAAC GATGCCTAAA TCCCAAATCG AAGCAAGCAA GGCTTATAAT CAAAAAAGTT 360 GAAAGAAAGA ATTTTTAAAA ATATCAAAAC ATATGAAGTC CTGGAAAAGG GCATCTGAAA 420 AACCTAGAAC AAGTTTAACT GTGACTACTG AAATGACAAG AATTCTACAG TAGGAAACTG 480 AGACTTTTCT ATGGTTTTGT GACTTTCAAC TTTTGTACAG TTATGTGAAG GATGAAAGGT 540 GGGTGAAAGG ACCAAAAACA GAAATACAGT CTTCCTGAAT GAATGACAAT CAGAATTCCA 600 CTGCCCAAAG GAGTCCAGCA ATTAAATGGA TTTCTAGGAA AAGCTACCTT AAGAAAGGCT 660 GGTTACCATC GGAGTTTACA AAGTGCTTTC ACGTTCTTAC TTGTTGTATT ATACATTCAT 720 GCATTTCTAG GCTAGAGAAC CTTCTAGATT TGATGCTTAC AACTATTCTG TTGTGACTAT 780 GAGAACATTT CTGTCTCTAG AAGTTATCTG TCTGTATTGA TCTTTATGCT ATATTACTAT 840 CTGTGGTTAC AGTGGAGACA TTGACATTAT TACTGGAGTC AAGCCCTTAT AAGTCAAAAG 900 CATCTATGTG TCGTAAAGCA TTCCTCAAAC ATTTTTTCAT GCAAATACAC ACTTCTTTCC 960 CCAAATATCA TGTAGCACAT CAATATGTAG GGAAACATTC TTATGCATCA TTTGGTTTGT 1020 TTTATAACCA ATTCATTAAA TGTAATTCAT AAAATGTACT ATGAAAAAAA TTATACGCTA 1080 TGGGATACTG GCAACAGTGC ACATATTTCA TAACCAAATT AGCAGCACCG GTCTTAATTT 1140 GATGTTTTTC AACTTTTATT CATTGAGATG TTTTGAAGCA ATTAGGATAT GTGTGTTTAC 1200 TGTACTTTTT GTTTTGATCC GTTTGTATAA ATGATAGCAA TATCTTGGAC ACATTTGAAA 1260 TACAAAATGT TTTTGTCTAC CAAAGAAAAA TGTTGAAAAA TAAGCAAATG TATACCTAGC 1320 AATCACTTTT ACTTTTTGTA ATTCTGTCTC TTAGAAAAAT ACATAATCTA ATCAATTTCT 1380 TTGTTCATGC CTATATACTG TAAAATTTAG GTATACTCAA GACTAGTTTA AAGAATCAAA 1440 GTCATTTTTT TCTCTAATAA ACTACCACAA CCTTTCTTTT TTAAAAAAAA AAA 1493 Seq ID NO : DNA Sequence 158 Nucleic Acid Accession # : Nom 002562. 1 Coding sequence : 27.. 1814 1 11 21 31 41 51 AAAACGCAGG GAGGGAGGCT GTCACCATGC CGGCCTGCTG CAGCTGCAGT GATGTTTTCC 60 AGTATGAGAC GAACAAAGTC ACTCGGATCC AGAGCATGAA TTATGGCACC ATTAAGTGGT 120 TCTTCCACGT GATCATCTTT TCCTACGTTT GCTTTGCTCT GGTGAGTGAC AAGCTGTACC 180 AGCGGAAAGA GCCTGTCATC AGTTCTGTGC ACACCAAGGT GAAGGGGATA GCAGAGGTGA 240 AAGAGGAGAT CGTGGAGAAT GGAGTGAAGA AGTTGGTGCA CAGTGTCTTT GACACCGCAG 300 ACTACACCTT CCCTTTGCAG GGGAACTCTT TCTTCGTGAT GACAAACTTT CTCAAAACAG 360 AAGGCCAAGA GCAGCGGTTG TGTCCCGAGT ATCCCACCCG CAGGACGCTC TGTTCCTCTG 420 ACCGAGGTTG TAAAAAGGGA TGGATGGACC CGCAGAGCAA AGGAATTCAG ACCGGAAGGT 480 GTGTAGTGCA TGAAGGGAAC CAGAAGACCT GTGAAGTCTC TGCCTGGTGC CCCATCGAGG 540 CAGTGGAAGA GGCCCCCCGG CCTGCTCTCT TGAACAGTGC CGAAAACTTC ACTGTGCTCA 600 TCAAGAACAA TATCGACTTC CCCGGCCACA ACTACACCAC GAGAAACATC CTGCCAGGTT 660 TAAACATCAC TTGTACCTTC CACAAGACTC AGAATCCACA GTGTCCCATT TTCCGACTAG 720 GAGACATCTT CCGAGAAACA GGCGATAATT TTTCAGATGT GGCAATTCAG GGCGGAATAA 780 TGGGCATTGA GATCTACTGG GACTGCAACC TAGACCGTTG GTTCCATCAC TGCCATCCCA 840 AATACAGTTT CCGTCGCCTT GACGACAAGA CCACCAACGT GTCCTTGTAC CCTGGCTACA 900 ACTTCAGATA CGCCAAGTAC TACAAGGAAA ACAATGTTGA GAAACGGACT CTGATAAAAG 960 TCTTCGGGAT CCGTTTTGAC ATCCTGGTTT TTGGCACCGG AGGAAAATTT GACATTATCC 1020 AGCTGGTTGT GTACATCGGC TCAACCCTCT CCTACTTCGG TCTGGCCGCT GTGTTCATCG 1080 ACTTCCTCAT CGACACTTAC TCCAGTAACT GCTGTCGCTC CCATATTTAT CCCTGGTGCA 1140 AGTGCTGTCA GCCCTGTGTG GTCAACGAAT ACTACTACAG GAAGAAGTGC GAGTCCATTG 1200 TGGAGCCAAA GCCGACATTA AAGTATGTGT CCTTTGTGGA TGAATCCCAC ATTAGGATGG 1260 TGAACCAGCA GCTACTAGGG AGAAGTCTGC AAGATGTCAA GGGCCAAGAA GTCCCAAGAC 1320 CTGCGATGGA CTTCACAGAT TTGTCCAGGC TGCCCCTGGC CCTCCATGAC ACACCCCCGA 1380 TTCCTGGACA ACCAGAGGAG ATACAGCTGC TTAGAAAGGA GGCGACTCCT AGATCCAGGG 1440 ATAGCCCCGT CTGGTGCCAG TGTGGAAGCT GCCTCCCATC TCAACTCCCT GAGAGCCACA 1500 GGTGCCTGGA GGAGCTGTGC TGCCGGAAAA AGCCGGGGGC CTGCATCACC ACCTCAGAGC 1560 TGTTCAGGAA GCTGGTCCTG TCCAGACACG TCCTGCAGTT CCTCCTGCTC TACCAGGAGC 1620 CCTTGCTGGC GCTGGATGTG GATTCCACCA ACAGCCGGCT GCGGCACTGT GCCTACAGGT 1680 GCTACGCCAC CTGGCGCTTC GGCTCCCAGG ACATGGCTGA CTTTGCCATC CTGCCCAGCT 1740 GCTGCCGCTG GAGGATCCGG AAAGAGTTTC CGAAGAGTGA AGGGCAGTAC AGTGGCTTCA 1800

AGAGTCCTTA CTGAAGCCAG GCACCGTGGC TCACGTCTGT AATCCCACCT TTT 1853 Seq ID NO : 159 DNA Sequence Nucleic Acid Accession # : NM_001793. 2 Coding sequence : 54-2543 1 11 21 31 41 51 AAAGGGGCAA GAGCTGAGCG GAACACCGGC CCGCCGTCGC GGCAGCTGCT TCACCCCTCT 60 CTCTGCAGCC ATGGGGCTCC CTCGTGGACC TCTCGCGTCT CTCCTCCTTC TCCAGGTTTG 120 CTGGCTGCAG TGCGCGGCCT CCGAGCCGTG CCGGGCGGTC TTCAGGGAGG CTGAAGTGAC 180 CTTGGAGGCG GGAGGCGCGG AGCAGGAGCC CGGCCAGGCG CTGGGGAAAG TATTCATGGG 240 CTGCCCTGGG CAAGAGCCAG CTCTGTTTAG CACTGATAAT GATGACTTCA CTGTGCGGAA 300 TGGCGAGACA GTCCAGGAAA GAAGGTCACT GAAGGAAAGG AATCCATTGA AGATCTTCCC 360 ATCCAAACGT ATCTTACGAA GACACAAGAG AGATTGGGTG GTTGCTCCAA TATCTGTCCC 420 TGAAAATGGC AAGGGTCCCT TCCCCCAGAG ACTGAATCAG CTCAAGTCTA ATAAAGATAG 480 AGACACCAAG ATTTTCTACA GCATCACGGG GCCGGGGGCA GACAGCCCCC CTGAGGGTGT 540 CTTCGCTGTA GAGAAGGAGA CAGGCTGGTT GTTGTTGAAT AAGCCACTGG ACCGGGAGGA 600 GATTGCCAAG TATGAGCTCT TTGGCCACGC TGTGTCAGAG AATGGTGCCT CAGTGGAGGA 660 CCCCATGAAC ATCTCCATCA TCGTGACCGA CCAGAATGAC CACAAGCCCA AGTTTACCCA 720 GGACACCTTC CGAGGGAGTG TCTTAGAGGG AGTCCTACCA GGTACTTCTG TGATGCAGGT 780 GACAGCCACG GATGAGGATG ATGCCATCTA CACCTACAAT GGGGTGGTTG CTTACTCCAT 840 CCATAGCCAA GAACCAAAGG ACCCACACGA CCTCATGTTC ACCATTCACC GGAGCACAGG 900 CACCATCAGC GTCATCTCCA GTGGCCTGGA CCGGGAAAAA GTCCCTGAGT ACACACTGAC 960 CATCCAGGCC ACAGACATGG ATGGGGACGG CTCCACCACC ACGGCAGTGG CAGTAGTGGA 1020 GATCCTTGAT GCCAATGACA ATGCTCCCAT GTTTGACCCC CAGAAGTACG AGGCCCATGT 1080 GCCTGAGAAT GCAGTGGGCC ATGAGGTGCA GAGGCTGACG GTCACTGATC TGGACGCCCC 1140 CAACTCACCA GCGTGGCGTG CCACCTACCT TATCATGGGC GGTGACGACG GGGACCATTT 1200 TACCATCACC ACCCACCCTG AGAGCAACCA GGGCATCCTG ACAACCAGGA AGGGTTTGGA 1260 TTTTGAGGCC AAAAACCAGC ACACCCTGTA CGTTGAAGTG ACCAACGAGG CCCCTTTTGT 1320 GCTGAAGCTC CCAACCTCCA CAGCCACCAT AGTGGTCCAC GTGGAGGATG TGAATGAGGC 1380 ACCTGTGTTT GTCCCACCCT CCAAAGTCGT TGAGGTCCAG GAGGGCATCC CCACTGGGGA 1440 GCCTGTGTGT GTCTACACTG CAGAAGACCC TGACAAGGAG AATCAAAAGA TCAGCTACCG 1500 CATCCTGAGA GACCCAGCAG GGTGGCTAGC CATGGACCCA GACAGTGGGC AGGTCACAGC 1560 TGTGGGCACC CTCGACCGTG AGGATGAGCA GTTTGTGAGG AACAACATCT ATGAAGTCAT 1620 GGTCTTGGCC ATGGACAATG GAAGCCCTCC CACCACTGGC ACGGGAACCC TTCTGCTAAC 1680 ACTGATTGAT GTCAATGACC ATGGCCCAGT CCCTGAGCCC CGTCAGATCA CCATCTGCAA 1740 CCAAAGCCCT GTGCGCCAGG TGCTGAACAT CACGGACAAG GACCTGTCTC CCCACACCTC 1800 CCCTTTCCAG GCCCAGCTCA CAGATGACTC AGACATCTAC TGGACGGCAG AGGTCAACGA 1860 GGAAGGTGAC ACAGTGGTCT TGTCCCTGAA GAAGTTCCTG AAGCAGGATA CATATGACGT 1920 GCACCTTTCT CTGTCTGACC ATGGCAACAA AGAGCAGCTG ACGGTGATCA GGGCCACTGT 1980 GTGCGACTGC CATGGCCATG TCGAAACCTG CCCTGGACCC TGGAAGGGAG GTTTCATCCT 2040 CCCTGTGCTG GGGGCTGTCC TGGCTCTGCT GTTCCTCCTG CTGGTGCTGC TTTTGTTGGT 210b GAGAAAGAAG CGGAAGATCA AGGAGCCCCT CCTACTCCCA GAAGATGACA CCCGTGACAA 2160 CGTCTTCTAC TATGGCGAAG AGGGGGGTGG CGAAGAGGAC CAGGACTATG ACATCACCCA 2220 GCTCCACCGA GGTCTGGAGG CCAGGCCGGA GGTGGTTCTC CGCAATGACG TGGCACCAAC 2280 CATCATCCCG ACACCCATGT ACCGTCCTCG GCCAGCCAAC CCAGATGAAA TCGGCAACTT 2340 TATAATTGAG AACCTGAAGG CGGCTAACAC AGACCCCACA GCCCCGCCCT ACGACACCCT 2400 CTTGGTGTTC GACTATGAGG GCAGCGGCTC CGACGCCGCG TCCCTGAGCT CCCTCACCTC 2460 CTCCGCCTCC GACCAAGACC AAGATTACGA TTATCTGAAC GAGTGGGGCA GCCGCTTCAA 2520 GAAGCTGGCA GACATGTACG GTGGCGGGGA GGACGACTAG GCGGCCTGCC TGCAGGGCTG 2580 GGGACCAAAC GTCAGGCCAC AGAGCATCTC CAAGGGGTCT CAGTTCCCCC TTCAGCTGAG 2640 GACTTCGGAG CTTGTCAGGA AGTGGCCGTA GCAACTTGGC GGAGACAGGC TATGAGTCTG 2700 ACGTTAGAGT GGTTGCTTCC TTAGCCTTTC AGGATGGAGG AATGTGGGCA GTTTGACTTC 2760 AGCACTGAAA ACCTCTCCAC CTGGGCCAGG GTTGCCTCAG AGGCCAAGTT TCCAGAAGCC 2820 TCTTACCTGC CGTAAAATGC TCAACCCTGT GTCCTGGGCC TGGGCCTGCT GTGACTGACC 2880 TACAGTGGAC TTTCTCTCTG GAATGGAACC TTCTTAGGCC TCCTGGTGCA ACTTAATTTT 2940 TTTTTTTAAT GCTATCTTCA AAACGTTAGA GAAAGTTCTT CAAAAGTGCA GCCCAGAGCT 3000 GCTGGGCCCA CTGGCCGTCC TGCATTTCTG GTTTCCAGAC CCCAATGCCT CCCATTCGGA 3060 TGGATCTCTG CGTTTTTATA CTGAGTGTGC CTAGGTTGCC CCTTATTTTT TATTTTCCCT 3120 GTTGCGTTGC TATAGATGAA GGGTGAGGAC AATCGTGTAT ATGTACTAGA ACTTTTTTAT 3180 TAAAGAAACT TTTCCCAGAA AAAAA 3205 Seq ID NO : 160 DNA Sequence Nucleic Acid Accession # : Nom002571. 1 Coding sequence : 99.. 587 1 11 21 31 41 51 I CATCCCTCTG GCTCCAGAGC TCAGAGCCAC CCACAGCCGC AGCCATGCTG TGCCTCCTGC 60 TCACCCTGGG CGTGGCCCTG GTCTGTGGTG TCCCGGCCAT GGACATCCCC CAGACCAAGC 120 AGGACCTGGA GCTCCCAAAG TTGGCAGGGA CCTGGCACTC CATGGCCATG GCGACCAACA 180 ACATCTCCCT CATGGCGACA CTGAAGGCCC CTCTGAGGGT CCACATCACC TCACTGTTGC 240 CCACCCCCGA GGACAACCTG GAGATCGTTC TGCACAGATG GGAGAACAAC AGCTGTGTTG 300 AGAAGAAGGT CCTTGGAGAG AAGACTGGGA ATCCAAAGAA GTTCAAGATC AACTATACGG 360 TGGCGAACGA GGCCACGCTG CTCGATACTG ACTACGACAA TTTCCTGTTT CTCTGCCTAC 420 AGGACACCAC CACCCCCATC CAGAGCATGA TGTGCCAGTA CCTGGCCAGA GTCCTGGTGG 480 AGGACGATGA GATCATGCAG GGATTCATCA GGGCTTTCAG GCCCCTGCCC AGGCACCTAT 540 GGTACTTGCT GGACTTGAAA CAGATGGAAG AGCCGTGCCG TTTCTAGCTC ACCTCCGCCT 600 CCAGGAAGAC CAGACTCCCA CCCTTCCACA CCTCCAGAGC AGTGGGACTT CCTCCTGCCC 660 TTTCAAAGAA TAACCACAGC TCAGAAGACG ATGACGTGGT CATCTGTGTC GCCATCCCCT 720 TCCTGCTGCA CACCTGCACC ATTGCCATGG GGAGGCTGCT CCCTGGGGGC AGAGTCTCTG 780 GCAGAGGTTA TTAATAAACC CTTGGAGCAT G 811 Seq ID NO : 161 DNA Sequence Nucleic Acid Accession # : NM_001327. 1

Coding sequence : 89.. 631 1 11 21 31 41 51 AGCAGGGGGC GCTGTGTGTA CCGAGAATAC GAGAATACCT CGTGGGCCCT GACCTTCTCT 60 CTGAGAGCCG GGCAGAGGCT CCGGAGCCAT GCAGGCCGAA GGCCGGGGCA CAGGGGGTTC 120 GACGGGCGAT GCTGATGGCC CAGGAGGCCC TGGCATTCCT GATGGCCCAG GGGGCAATGC 180 TGGCGGCCCA GGAGAGGCGG GTGCCACGGG CGGCAGAGGT CCCCGGGGCG CAGGGGCAGC 240 AAGGGCCTCG GGGCCGGGAG GAGGCGCCCC GCGGGGTCCG CATGGCGGCG CGGCTTCAGG 300 GCTGAATGGA TGCTGCAGAT GCGGGGCCAG GGGGCCGGAG AGCCGCCTGC TTGAGTTCTA 360 CCTCGCCATG CCTTTCGCGA CACCCATGGA AGCAGAGCTG GCCCGCAGGA GCCTGGCCCA 420 GGATGCCCCA CCGCTTCCCG TGCCAGGGGT GCTTCTGAAG GAGTTCACTG TGTCCGGCAA 480 CATACTGACT ATCCGACTGA CTGCTGCAGA CCACCGCCAA CTGCAGCTCT CCATCAGCTC 540 CTGTCTCCAG CAGCTTTCCC TGTTGATGTG GATCACGCAG TGCTTTCTGC CCGTGTTTTT 600 GGCTCAGCCT CCCTCAGGGC AGAGGCGCTA AGCCCAGCCT GGCGCCCCTT CCTAGGTCAT 660 GCCTCCTCCC CTAGGGAATG GTCCCAGCAC GAGTGGCCAG TTCATTGTGG GGGCCTGATT 720 GTTTGTCGCT GGAGGAGGAC GGCTTACATG TTTGTTTCTG TAGAAAATAA AACTGAGCTA 780 Seq ID NO : 162 DNA Sequence Nucleic Acid Accession # : NM020994 Coding sequence : 53.. 459 1 11 21 31 41 si CCTCGTGGGC CCTGACCTTC TCTCTGAGAG CCGGGCAGAG GCTCCGGAGC CATGCAGGCC 60 GAAGGCCAGG GCACAGGGGG TTCGACGGGC GATGCTGATG GCCCAGGAGG CCCTGGCATT 120 CCTGATGGCC CAGGGGGCAA TGCTGGCGGC CCAGGAGAGG CGGGTGCCAC GGGCGGCAGA 180 GGTCCCCGGG GCGCAGGGGC AGCAAGGGCC TCGGGGCCGA GAGGAGGCGC CCCGCGGGGT 240 CCGCATGGCG GTGCCGCTTC TGCGCAGGAT GGAAGGTGCC CCTGCGGGGC CAGGAGGCCG 300 GACAGCCGCC TGCTTCAGTT CCGACTGACT GCTGCAGACC ACCGCCAACT GCAGCTCTCC 360 ATCAGCTCCT GTCTCCAGCA GCTTTCCCTG TTGATGTGGA TCACGCAGTG CTTTCTGCCC 420 GTGTTTTTGG CTCAGGCTCC CTCAGGGCAG AGGCGCTAAG CCCAGCCTGG CGCCCCTTCC 480 TAGGTCATGC CTCCTCCCCT AGGGAATGGT CCCAGCACGA GTGGCCAGTT CATTGTGGGG 540 GCCTGATTGT TTGTCGCTGG AGGAGGACGG CTTACATGTT TGTTTCTGTA GAAAATAAAG 600 CTGAGCTA 608 Seq ID NO : 163 DNA Sequence Nucleic Acid Accession # : Nom 006928. 2 Coding sequence : 1.. 1986 1 11 21 31 41 51 ATGGATCTGG TGCTAAAAAG ATGCCTTCTT CATTTGGCTG TGATAGGTGC TTTGCTGGCT 60 GTGGGGGCTA CAAAAGTACC CAGAAACCAG GACTGGCTTG GTGTCTCAAG GCAACTCAGA 120 ACCAAAGCCT GGAACAGGCA GCTGTATCCA GAGTGGACAG AAGCCCAGAG ACTTGACTGC 180 TGGAGAGGTG GTCAAGTGTC CCTCAAGGTC AGTAATGATG GGCCTACACT GATTGGTGCA 240 AATGCCTCCT TCTCTATTGC CTTGAACTTC CCTGGAAGCC AAAAGGTATT GCCAGATGGG 300 CAGGTTATCT GGGTCAACAA TACCATCATC AATGGGAGCC AGGTGTGGGG AGGACAGCCA 360 GTGTATCCCC AGGAAACTGA CGATGCCTGC ATCTTCCCTG ATGGTGGACC TTGCCCATCT 420 GGCTCTTGGT CTCAGAAGAG AAGCTTTGTT TATGTCTGGA AGACCTGGGG CCAATACTGG 480 CAAGTTCTAG GGGGCCCAGT GTCTGGGCTG AGCATTGGGA CAGGCAGGGC AATGCTGGGC 540 ACACACACCA TGGAAGTGAC TGTCTACCAT CGCCGGGGAT CCCGGAGCTA TGTGCCTCTT 600 GCTCATTCCA GCTCAGCCTT CACCATTACT GACCAGGTGC CTTTCTCCGT GAGCGTGTCC 660 CAGTTGCGGG CCTTGGATGG AGGGAACAAG CACTTCCTGA GAAATCAGCC TCTGACCTTT 720 GCCCTCCAGC TCCATGACCC CAGTGGCTAT CTGGCTGAAG CTGACCTCTC CTACACCTGG 780 GACTTTGGAG ACAGTAGTGG AACCCTGATC TCTCGGGCAC TTGTGGTCAC TCATACTTAC 840 CTGGAGCCTG GCCCAGTCAC TGCCCAGGTG GTCCTGCAGG CTGCCATTCC TCTCACCTCC 900 TGTGGCTCCT CCCCAGTTCC AGGCACCACA GATGGGCACA GGCCAACTGC AGAGGCCCCT 960 AACACCACAG CTGGCCAAGT GCCTACTACA GAAGTTGTGG GTACTACACC TGGTCAGGCG 1020 CCAACTGCAG AGCCCTCTGG AACCACATCT GTGCAGGTGC CAACCACTGA AGTCATAAGC 1080 ACTGCACCTG TGCAGATGCC AACTGCAGAG AGCACAGGTA TGACACCTGA GAAGGTGCCA 1140 GTTTCAGAGG TCATGGGTAC CACACTGGCA GAGATGTCAA CTCCAGAGGC TACAGGTATG 1200 ACACCTGCAG AGGTATCAAT TGTGGTGCTT TCTGGAACCA CAGCTGCACA GGTAACAACT 1260 ACAGAGTGGG TGGAGACCAC AGCTAGAGAG CTACCTATCC CTGAGCCTGA AGGTCCAGAT 1320 GCCAGCTCAA TCATGTCTAC GGAAAGTATT ACAGGTTCCC TGGGCCCCCT GCTGGATGGT 1380 ACAGCCACCT TAAGGCTGGT GAAGAGACAA GTCCCCCTGG ATTGTGTTCT GTATCGATAT 1440 GGTTCCTTTT CCGTCACCCT GGACATTGTC CAGGGTATTG AAAGTGCCGA GATCCTGCAG 1500 GCTGTGCCGT CCGGTGAGGG GGATGCATTT GAGCTGACTG TGTCCTGCCA AGGCGGGCTG 1560 CCCAAGGAAG CCTGCATGGA GATCTCATCG CCAGGGTGCC AGCCCCCTGC CCAGCGGCTG 1620 TGCCAGCCTG TGCTACCCAG CCCAGCCTGC CAGCTGGTTC TGCACCAGAT ACTGAAGGGT 1680 GGCTCGGGGA CATACTGCCT CAATGTGTCT CTGGCTGATA CCAACAGCCT GGCAGTGGTC 1740 AGCACCCAGC TTATCATGCC TGGTCAAGAA GCAGGCCTTG GGCAGGTTCC GCTGATCGTG 1800 GGCATCTTGC TGGTGTTGAT GGCTGTGGTC CTTGCATCTC TGATATATAG GCGCAGACTT 1860 ATGAAGCAAG ACTTCTCCGT ACCCCAGTTG CCACATAGCA GCAGTCACTG GCTGCGTCTA 1920 CCCCGCATCT TCTGCTCTTG TCCCATTGGT GAGAATAGCC CCCTCCTCAG TGGGCAGCAG 1980 GTCTGA 1986 Seq ID NO : 164 DNA Sequence Nucleic Acid Accession # : Nom 001922. 2 Coding sequence : 415.. 1974 1 11 21 31 41 51 GCAATTAAAG TCAAGAGCTA AGGAGGGAGG GAGAGGGTTT AGAAATACCA GCATAATAAG 60 TAGTATGACT GGGTGCTCTG TAAATTAACT CAATTAGACA AAGCCTGACT TAACGGGGGA 120 AGATGGTGAG AAGCGCTACC CTCATTAAAT TTGGTTGTTA GAGGCGCTTC TAAGGAAATT 180 AAGTCTGTTA GTTGTTTGAA TCACATAAAA TTGTGTGTGC ACGTTCATGT ACACATGTGC 240 ACACATGTAA CCTCTGTGAT TCTTGTGGGT ATTTTTTTAA GAAGAAAGGA ATAGAAAGCA 300

AAGAAAAATA AAAAATACTG AAAAGAAAAG ACTGAAAGAG TAGAAGATAA GGAGAAAAGT 360 ACGACAGAGA CAAGGAAAGT AAGAGAGAGA GAGAGCTCTC CCAATTATAA AGCCATGAGC 420 CCCCTTTGGT GGGGGTTTCT GCTCAGTTGC TTGGGCTGCA AAATCCTGCC AGGAGCCCAG 480 GGTCAGTTCC CCCGAGTCTG CATGACGGTG GACAGCCTAG TGAACAAGGA GTGCTGCCCA 540 CGCCTGGGTG CAGAGTCGGC CAATGTCTGT GGCTCTCAGC AAGGCCGGGG GCAGTGCACA 600 GAGGTGCGAG CCGACACAAG GCCCTGGAGT GGTCCCTACA TCCTACGAAA CCAGGATGAC 660 CGTGAGCTGT GGCCAAGAAA ATTCTTCCAC CGGACCTGCA AGTGCACAGG AAACTTTGCC 720 GGCTATAATT GTGGAGACTG CAAGTTTGGC TGGACCGGTC CCAACTGCGA GCGGAAGAAA 780 CCACCAGTGA TTCGGCAGAA CATCCATTCC TTGAGTCCTC AGGAAAGAGA GCAGTTCTTG 840 GGCGCCTTAG ATCTCGCGAA GAAGAGAGTA CACCCCGACT ACGTGATCAC CACACAACAC 900 TGGCTGGGCC TGCTTGGGCC CAATGGAACC CAGCCGCAGT TTGCCAACTG CAGTGTTTAT 960 GATTTTTTTG TGTGGCTCCA TTATTATTCT GTTAGAGATA CATTATTAGG ACCAGGACGC 1020 CCCTACAGGG CCATAGATTT CTCACATCAA GGACCTGCAT TTGTTACCTG GCACCGGTAC 1080 CATTTGTTGT GTCTGGAAAG AGATCTCCAG CGACTCATTG GCAATGAGTC TTTTGCTTTG 1140 CCCTACTGGA ACTTTGCCAC TGGGAGGAAC GAGTGTGATG TGTGTACAGA CCAGCTGTTT 1200 GGGGCAGCGA GACCAGACGA TCCGACTCTG ATTAGTCGGA ACTCAAGATT CTCCAGCTGG 1260 GAAACTGTCT GTGATAGCTT GGATGACTAC AACCACCTGG TCACCTTGTG CAATGGAACC 1320 TATGAAGGTT TGCTGAGAAG AAATCAAATG GGAAGAAACA GCATGAAATT GCCAACCTTA 1380 AAAGACATAC GAGATTGCCT GTCTCTCCAG AAGTTTGACA ATCCTCCCTT CTTCCAGAAC 1440 TCTACCTTCA GTTTCAGGAA TGCTTTGGAA GGGTTTGATA AAGCAGATGG GA « CTGGAT 1500 TCTCAAGTGA TGAGCCTTCA TAATTTGGTT CATTCCTTCC TGAACGGGAC AAACGCTTTG 1560 CCACATTCAG CCGCCAATGA TCCCATTTTT GTGGTTCTTC ATTCCTTTAC TGATGCCATC 1620 TTTGATGAGT GGATGAAAAG ATTTAATCCT CCTGCAGATG CCTGGCCTCA GGAGCTGGCC 1680 CCTATTGGTC ACAATCGGAT GTACAACATG GTTCCTTTCT TCCCTCCAGT GACTAATGAA 1740 GAACTCTTTT TAACCTCAGA CCAACTTGGC TACAGCTATG CCATCGATCT GCCAGTTTCA 1800 GTTGAAGAAA CTCCAGGTTG GCCCACAACT CTCTTAGTAG TCATGGGAAC ACTGGTGGCT 1860 TTGGTTGGTC TTTTTGTGCT GTTGGCTTTT CTTCAATATA GAAGACTTCG AAAAGGATAT 1920 ACACCCCTAA TGGAGACACA TTTAAGCAGC AAGAGATACA CAGAAGAAGC CTAGGGTGCT 1980 CATGCCTTAC CTAAGAGAAG AGGCTGGCCA AGCCACAGTT CTGACGCTGA CAATAAAGGA 2040 ACTAATCCTC ACTGTTCCTT CTTGAGTTGA AGATCTTTGA CATAGGTTCT TCTATAGTGA 2100 TGATGATCTC ATTCAGAAGA TGCTTAGCTG TAGTTTCCGC TTTGCTTGCT TGTTTAACAA 2160 ACCCAACTAA AGTGCTTGAG GCTACCTCTA CCTTCAAATA AAGATAGACC TGACAATTTG 2220 TGATATCTAA TAATAACCCC CCCCCCAATA TTGATTAAGC CTCCTCCTTT TCTGAAAGCA 2280 TTTAAAAAAA A 2291 Seq ID NO : 165 DNA Sequence Nucleic Acid Accession # : XM_059422. 3 Coding sequence : 207.. 1400 1 11 21 31 41 51 TGTGGGGCTG CCCGGGCTGC GCGGCGTCTG CAGGCGCCAC CGCTGCCTCT TTCCGGCTGT 60 GACCCTCCTC GCCGCCGCCG CTTGGCTGCG TCCTCCGACT CCCCGCGCCG CCGAGACCAG 120 GCTCCCGCTC CGGTTGCGGC CGCACCGCCC TCCGCGGCCG CCCCCTGGGG ATCCAGCGAG 180 CGCGGTCGTC CTTGGTGGAA GGAACCATGA ACTGGCATCT CCCCCTCTTC CTCTTGGCCT 240 CTGTGACGCT GCCTTCCATC TGCTCCCACT TCAATCCTCT GTCTCTCGAG GAACTAGGCT 300 CCAACACGGG GATCCAGGTT TTCAATCAGA TTGTGAAGTC GAGGCCTCAT GACAACATCG 360 TGATCTCTCC CCATGGGATT GCGTCGGTCC TGGGGATGCT TCAGCTGGGG GCGGACGGCA 420 GGACCAAGAA GCAGCTCGCC ATGGTGATGA GATACGGCGT AAATGGAGTT GGTAAAATAT 480 TAAAGAAGAT CAACAAGGCC ATCGTCTCCA AGAAGAATAA AGACATTGTG ACAGTGGCTA 540 ACGCCGTGTT TGTTAAGAAT GCCTCTGAAA TTGAAGTGCC TTTTGTTACA AGGAACAAAG 600 ATGTGTTCCA GTGTGAGGTC CGGAATGTGA ACTTTGAGGA TCCAGCCTCT GCCTGTGATT 660 CCATCAATGC ATGGGTTAAA AATGAAACCA GGGATATGAT TGACAATCTG CTGTCCCCAG 720 ATCTTATTGA TGGTGTGCTC ACCAGACTGG TCCTCGTCAA CGCAGTGTAT TTCAAGGGTC 780 TGTGGAAATC ACGGTTCCAA CCCGAGAACA CAAAGAAACG CACTTTCGTG GCAGCCGACG 840 GGAAATCCTA TCAAGTGCCA ATGCTGGCCC AGCTCTCCGT GTTCCGGTGT GGGTCGACAA 900 GTGCCCCCAA TGATTTATGG TACAACTTCA TTGAACTGCC CTACCACGGG GAAAGCATCA 960 GCATGCTGAT TGCACTGCCG ACTGAGAGCT CCACTCCGCT GTCTGCCATC ATCCCACACA 1020 TCAGCACCAA GACCATAGAC AGCTGGATGA GCATCATGGT GCCCAAGAGG GTGCAGGTGA 1080 TCCTGCCCAA GTTCACAGCT GTAGCACAAA CAGATTTGAA GGAGCCGCTG AAAGTTCTTG 1140 GCATTACTGA CATGTTTGAT TCATCAAAGG CAAATTTTGC AAAAATAACA AGGTCAGAAA 1200 ACCTCCATGT TTCTCATATC TTGCAAAAAG CAAAAATTGA AGTCAGTGAA GATGGAACCA 1260 AAGCTTCAGC AGCAACAACT GCAATTCTCA TTGCAAGATC ATCGCCTCCC TGGTTTATAG 1320 TAGACAGACC TTTTCTGTTT TTCATCCGAC ATAATCCTAC AGGTGCTGTG TTATTCATGG 1380 GGCAGATAAA CAAACCCTGA AGAGTATACA AAAGAAACCA TGCAAAGCAA CGACTACTTT 1440 GCTACGAAGA AAGACTCCTT TCCTGCATCT TTCATAGTTC TGTTAAATAT TTTTGTACAT 1500 CGCTTCTTTT TCAAAACTAG TTCTTAGGAA CAGACTCGAT GCAAGTGTTT CTGTTCTGGG 1560 AGGTATTGGA GGGAAAAAAC AAGCAGGATG GCTGGAACAC TGTACTGAGG AATGAATAGA 1620 AAGGCTTCCA GATGTCTAAA AGATTCTTTA AACTACTGAA CTGTTACCTA GGTTAACAAC 1680 CCTGTTGAGT ATTTGCTGTT TGTCCAGTTC AGGAATTTTT GTTTTGTTTT GTCTATATGT 1740 GCGGCTTTTC AGAAGAAATT TAATCAGTGT GACAGAAAAA AAAATGTTTT ATGGTAGCTT 1800 TTACTTTTTA TGAAAAAAAA ATTATTTGCC TTTTAAATTC TTTTCCCCCA TCCCCCTCCA 1860 AAGTCTTGAT AGCAAGCGTT ATTTTGGTGG TAGAAACGGT GAAATCTCTA GCCTCTTTGT 1920 GTTTTTGTTG TTGTTGTTGT TGTTGTTTTA TATAATGCAT GTATTCACTA AAATAAAATT 1980 TAAAAAACTC CTGTCTTGCT AGACAAGGTT GCTGTTGTGC AGTGTGCCTG TCACTACTGG 2040 TCTGTACTCC TTGGATTTGC ATTTTTGTAT TTTGTACAAA GTAAAAATAA ACTGTTATGA 2100 GTAGT 2105 Seq ID NO : 166 DNA Sequence Nucleic Acid Accession # : XM 040512. 3 Coding sequence : 382.. 1302 1 11 21 31 41 51 GGGGCCGCCG GGCAGGAGGA GTTGGAGGAG GACGATGCCT TTATCAGCGT GCAGGTGCCG 60 GCGGCCGCCT TTTTGGGCTC CGGGACCCCC GGGAGTGGGA GCGGCAGTCG GGGACGCCTC 120

AACTCGTTCA CTCAGGGAAT CCTGCCCATC GCCTTCTCCA GGCCGACTTC GCAGAACTAC 180 TGCTCCCTGG AGCAGCCAGG CCAGGGCGGC AGCACCAGCG CCTTCGAGCA GCTGCAGAGG 240 TCCCGACGGC GCCTCATCTC CCAGAGATCT TCCTTGGAGA CCCTGGAAGA TATTGAGGAG 300 AACGCCCCTC TCCGGAGATG TCGAACTCTC TCAGGTTCAC CCAGACCAAA GAATTTTAAG 360 AAGATTCATT TTATCAAGAA CATGCGGCAA CACGATACCA GGAATGGCAG AATAGTCCTT 420 ATCAGTGGCA GAAGATCCTT CTGTAGTATA TTTTCAGTGC TGCCGTATCG CGACAGTACC 480 CAAGTCGGGG ACTTGAAGTT GGACGGAGGA AGACAATCAA CTGGTGCAGT GAGTTTGAAA 540 GAGATCATTG GTCTGGAAGG TGTGGAGCTG GGTGCTGATG GGAAGACTGT TTCCTATACC 600 CAATTTCTGT TACCCACAAA TGCCTTTGGA GCCCGGAGAA ATACCATAGA CTCCACCTCC 660 TCTTTCTCCC AGTTCCGTAA CCTGAGCCAC CGCAGCCTCT CCATAGGCCG GGCAAGCGGC 720 ACCCAGGGGA GCCTCGACAC AGGTAGTGAC CTGGGAGACT TTATGGACTA TGACCCAAAT 780 CTCTTGGATG ACCCCCAGTG GCCTTGTGGC AAACACAAAC GCGTTCTGAT CTTCCCTTCC 840 TACATGACAA CAGTGATTGA CTACGTGAAG CCCTCGGATC TCAAGAAGGA CATGAACGAG 900 ACCTTCAAGG AGAAGTTTCC TCACATTAAG CTGACACTCA GCAAAATTAG GAGTCTGAAA 960 CGAGAGATGC GGAAGCTTGC GCAGGAGGAC TGTGGCCTTG AGGAGCCCAC GGTGGCCATG 1020 GCCTTCGTCT ACTTTGAAAA GCTCGCCCTC AAGGGGAAAC TCAACAAACA GAACCGGAAG 1080 CTGTGTGCTG GGGCATGTGT GCTGTTAGCA GCCAAAATTG GAAGTGACCT CAAAAAACAC 1140 GAAGTCAAGC ATTTAATTGA CAAACTGGAA GAGAAGTTCC GGCTGAACAG GCGAGAACTG 1200 ATTGCCTTTG AATTCCCGGT GTTAGTGGCC TTGGAATTCG CCCTCCACTT GCCCGAGCAC 1260 GAAGTCATGC CCCACTACAG ACGGCTGGTC CAGAGTTCCT AGCACTGGCC CCGAGGACAG 1320 CCAAGGGCCA TTTCTTCTCA GCTTGGTGGA GCAGCACTTA CTTACTACTG GAAATGAAAA 1380 AAAGTAGAAC TCAGAATACC AGACTTTTCT TCCTCTCGAC ATAGTTTGGG GAGAAGCAGT 1440 ACTAGAAACT TTCCAAGGAG TCTTGGGTGT GTAGCCAAGA GGAGCCATGA GCTATGGACT 1500 CCTCAAGCAC GGGAAGAGGA GGTGTGTGCT GAGAACAGAG AGGCCCTGCC CTCTGTCCAC 1560 TAGCGAGAAT CCCTAGCTGC CCCAGCCCAG TCTTTCTCCC CGGCATTCAC AAACTTTGCA 1620 AGCGTGGTCC AGGGCCTTCT CCAGATCTGT TCCAACTTGG AGTGTGAAGG GCTTGAGCAT 1680 ACGGGGGAAG AGAGTCTGCA GAAGTTGGGG GAAAACTTTT AAAAGATACC CTCATTGTGT 1740 CAAAGAGTGT GCCAATCTAT TTTTGTATCA GCATTGGAAG TGCACTTTCC CCTGGGGCGT 1800 GTGGGTGTGT GAATGTGCAA GTGTCTGAGA GATACTGCAT CAGCCCTAGA CCCCCAGAGC 1860 CAGTCCCGCC CTTTACAGAG CAGCCCTTAG CCTGGGGCCA TGGGTCAGGC TGACCTTCAA 1920 CAATTATTTC TAGATGATTT CTGGATAAGA ATTGCTCTCT CGGTACCAGA CAGTTTGACA 1980 TCCTCCACCC TTAGAAAATG ACTGACATTG TTTTGTTACT GCTCCTACCC ACCAAGGGGA 2040 TAAAGAAGGC GAGTTCTGAG TGTTGGATGA GTCAGTCGCG TGGAAGGACG TGGAGCGTGG 2100 CGCTCTGTAA CTTCCTGCCG TCTGCCACCC CGCCACGTGT ATTTAACCCT CGCACTTTCT 2160 CCACTGTGGA GATGGCTGGG GCGGCGCCCC ACAGTGTGTA TTCCTGTCCT CTATGTTAGA 2220 GTGCATCAGA AGCACATTTA CTGTGCTATC TATATCGCTA TATAAAAGTG TTTTATAAAA 2280 ACCCAGAATA GGAGCACGAC GCATGATTGG TGTTTGAGGC GTTTGCCAGC TGGGACAAAC 2340 TGCGTTTGGA GCTGTGGTTA AGCTGACTAA GGAGGCCGTG GCTCTTTCTT AACATTCCCA 2400 CGTGCCCAGG GCTGTTCATG CAAGATTTTA ATGGTGACTT GTCCTGGCTT ACTGGGACAG 2460 TCTGTATGAG GCATGTCACC ACACTGTCGC CTCATAGCTG CAAGAGAGAG GCACCAGCTG 2520 AAGTTCCCCT GACTGAAGAG AGCCTGTGGC CATGTAAAAA GAGAATTAAA CTCTTGTTGC 2580 TTTTTGT 2587 Seq ID NO : 167 DNA Sequence Nucleic Acid Accession t : BC008826 Coding sequence : 188.. 2695 1 11 21 31 41 51 GGCACGAGGC TCCGGCCTCT GGACTAGGAA CCGACAGCCC CCCTCCCCGC GTCCCTCCCT 60 CTCTCTCCAG CCGTTTTGGG GAGGGGCTCT CCACGCTCCG GATAGTTCCC GAGGGTCATC 120 CGCGCCGCAC TCGCCTTTCC GTTTCGCCTT CACCTGGATA TAATTTCCGA GCGAAGCTGC 180 CCCCAGGATG ACCACGCTGG CCGGCGCTGT GCCCAGGATG ATGCGGCCGG GCCCGGGGCA 240 GAACTACCCG CGTAGCGGGT TCCCGCTGGA AGTGTCCACT CCCCTCGGCC AGGGCCGCGT 300 CAACCAGCTC GGCGGCGTTT TTATCAACGG CAGGCCGCTG CCCAACCACA TCCGCCACAA 360 GATCGTGGAG ATGGCCCACC ACGGCATCCG GCCCTGCGTC ATCTCGCGCC AGCTGCGCGT 420 GTCCCACGGC TGCGTCTCCA AGATCCTGTG CAGGTACCAG GAGACTGGCT CCATACGTCC 480 TGGTGCCATC GGCGGCAGCA AGCCCAAGGT GACAACGCCT GACGTGGAGA AGAAAATTGA 540 GGAATACAAA AGAGAGAACC CGGGCATGTT CAGCTGGGAA ATCCGAGACA AATTACTCAA 600 GGACGCGGTC TGTGATCGAA ACACCGTGCC GTCAGTGAGT TCCATCAGCC GCATCCTGAG 660 AAGTAAATTC GGGAAAGGTG AAGAGGAGGA GGCCGACTTG GAGAGGAAGG AGGCAGAGGA 720 AAGCGAGAAG AAGGCCAAAC ACAGCATCGA CGGCATCCTG AGCGAGCGAG CCTCAGCACC 780 CCAATCAGAT GAAGGCTCTG ATATTGACTC TGAACCAGAT TTACCACTAA AGAGGAAACA 840 GCGCAGAAGC CGAACCACCT TCACAGCAGA ACAGCTGGAG GAACTGGAGC GTGCTTTTGA 900 GAGAACTCAT TACCCTGACA TTTATACTAG GGAGGAACTG GCCCAGAGGG CGAAGCTCAC 960 CGAGGCCCGA GTACAGGTCT GGTTTAGCAA CCGCCGTGCA AGATGGAGGA AGCAAGCTGG 1020 GGCCAATCAA CTGATGGCTT TCAACCATCT CATTCCCGGG GGGTTCCCTC CCACTGCCAT 1080 GCCGACCTTG CCAACGTACC AGCTGTCGGA GACCTCTTAC CAGCCCACAT CTATTCCACA 1140 AGCTGTGTCA GATCCCAGCA GCACCGTTCA CAGACCTCAA CCGCTTCCTC CAAGCACTGT 1200 ACACCAAAGC ACGATTCCTT CCAACCCAGA CAGCAGCTCT GCCTACTGCC TCCCCAGCAC 1260 CAGGCATGGA TTTTCCAGCT ATACAGACAG CTTTGTGCCT CCGTCGGGGC CCTCCAACCC 1320 CATGAACCCC ACCATTGGCA ATGGCCTCTC ACCTCAGAAT TCAATTCGTC ATAATCTGTC 1380 CCTACACAGC AAGTTCATTC GTGTGCAGAA TGAAGGAACT GGAAAAAGTT CTTGGTGGAT 1440 GCTCAATCCA GAGGGTGGCA AGAGCGGGAA ATCTCCTAGG AGAAGAGCTG CATCCATGGA 1500 CAACAACAGT AAATTTGCTA AGAGCCGAAG CCGAGCTGCC AAGAAGAAAG CATCTCTCCA 1560 GTCTGGCCAG GAGGGTGCTG GGGACAGCCC TGGATCACAG TTTTCCAAAT GGCCTGCAAG 1620 CCCTGGCTCT CACAGCAATG ATGACTTTGA TAACTGGAGT ACATTTCGCC CTCGAACTAG 1680 CTCAAATGCT AGTACTATTA GTGGGAGACT CTCACCCATT ATGACCGAAC AGGATGATCT 1740 TGGAGAAGGG GATGTGCATT CTATGGTGTA CCCGCCATCT GCCGCAAAGA TGGCCTCTAC 1800 TTTACCCAGT CTGTCTGAGA TAAGCAATCC CGAAAACATG GAAAATCTTT TGGATAATCT 1860 CAACCTTCTC TCATCACCAA CATCATTAAC TGTTTCGACC CAGTCCTCAC CTGGCACCAT 1920 GATGCAGCAG ACGCCGTGCT ACTCGTTTGC GCCACCAAAC ACCAGTTTGA ATTCACCCAG 1980 CCCAAACTAC CAAAAATATA CATATGGCCA ATCCAGCATG AGCCCTTTGC CCCAGATGCC 2040 TATACAAACA CTTCAGGACA ATAAGTCGAG TTATGGAGGT ATGAGTCAGT ATAACTGTGC 2100 GCCTGGACTC TTGAAGGAGT TGCTGACTTC TGACTCTCCT CCCCATAATG ACATTATGAC 2160

ACCAGTTGAT CCTGGGGTAG CCCAGCCCAA CAGCCGGGTT CTGGGCCAGA ACGTCATGAT 2220 GGGCCCTAAT TCGGTCATGT CAACCTATGG CAGCCAGGCA TCTCATAACA AAATGATGAA 2280 TCCCAGCTCC CATACCCACC CTGGACATGC TCAGCAGACA TCTGCAGTTA ACGGGCGTCC 2340 CCTGCCCCAC ACGGTAAGCA CCATGCCCCA CACCTCGGGT ATGAACCGCC TGACCCAAGT 2400 GAAGACACCT GTACAAGTGC CTCTGCCCCA CCCCATGCAG ATGAGTGCCC TGGGGGGCTA 2460 CTCCTCCGTG AGCAGCTGCA ATGGCTATGG CAGAATGGGC CTTCTCCACC AGGAGAAGCT 2520 CCCAAGTGAC TTGGATGGCA TGTTCATTGA GCGCTTAGAC TGTGACATGG AATCCATCAT 2580 TCGGAATGAC CTCATGGATG GAGATACATT GGATTTTAAC TTTGACAATG TGTTGCCCAA 2640 CCAAAGCTTC CCACACAGTG TCAAGACAAC GACACATAGC TGGGTGTCAG GCTGAGGGTT 2700 AGTGAGCAGG TTACACTTAA AAGTACTTCA GATTGTCTGA CAGCAGGAAC TGAGAGAAGC 2760 AGTCCAAAGA TGTCTTTCAC CAACTCCCTT TTAGTTTTCT TGGTTAAAAA AAAAAAAAAA 2820 AAAAAAA 2827 Seq ID NO : 168 DNA Sequence Nucleic Acid Accession # : Nom 005761. 1 Coding sequence : 250.. 4956 1 11 21 31 41 51 GCGAGGAGGA AACGGTGCCG GAGCGCGCAG GGCTTGCTGC CGCCACCGCC GCTGCACAGG 60 CTGCCGGAGC GAGCCTGCCG CGCGCCGCCC TCCCCGCTCT CCTTCCTGGG CGAGCTGCGG 120 GGATGGGGCG GCCGCGGGAG CCCGAGCGCG CGCAGGAACC GCCGCCGCCG CCGCCCGCGT 180 CTCCGTTGCC GCGCGCCTGA GCCGCCGTCG CCGCCGCGCG CCCTGCCCGG GGGCGGCCCC 240 CCCAGCCCCA TGGAGGTCTC CCGGAGGAAG GCGCCGCCGC GCCCCCCGCG CCCCGCAGCG 300 CCACTGCCCC TGCTCGCCTA TCTGCTGGCA CTGGCGGCTC CCGGCCGGGG CGCGGACGAG 360 CCCGTGTGGC GGTCGGAGCA AGCCATCGGA GCCATCGCGG CGAGCCAGGA GGACGGCGTG 420 TTTGTGGCGA GCGGCAGCTG CCTGGACCAG CTGGACTACA GCCTGGAGCA CAGCCTCTCG 480 CGCCTGTACC GGGACCAAGC GGGCAACTGC ACAGAGCCGG TCTCGCTGGC GCCCCCCGCG 540 CGGCCCCGGC CCGGGAGCAG CTTCAGCAAG CTGCTGCTGC CCTACCGCGA GGGGGCGGCC 600 GGCCTCGGGG GGCTGCTGCT CACCGGCTGG ACCTTCGACC GGGGCGCCTG CGAGGTGCGG 660 CCCCTGGGCA ACCTGAGCCG CAACTCCCTG CGCAACGGCA CCGAGGTGGT GTCGTGCCAC 720 CCGCAGGGCT CGACGGCCGG CGTGGTGTAC CGCGCGGGCC GGAACAACCG CTGGTACCTG 780 GCGGTGGCCG CCACCTACGT GCTGCCTGAG CCGGAGACGG CGAGCCGCTG CAACCCCGCG 840 GCATCCGACC ACGACACGGC CATCGCGCTC AAGGACACGG AGGGGCGCAG CCTGGCCACG 900 CAGGAGCTGG GGCGCCTCAA GCTGTGCGAG GGCGCGGGCA GCCTGCACTT CGTGGACGCC 960 TTTCTCTGGA ACGGCAGCAT CTACTTCCCC TACTACCCCT ACAACTATAC GAGCGGCGCT 1020 GCCACCGGCT GGCCCAGCAT GGCGCGCATC GCGCAGAGCA CCGAGGTGCT GTTCCAGGGC 1080 CAGGCATCCC TCGACTGCGG CCACGGCCAC CCCGACGGCC GCCGCCTGCT CCTCTCCTCC 1140 AGCCTAGTGG AGGCCCTGGA CGTCTGGGCG GGAGTGTTCA GCGCGGCCGC TGGAGAGGGC 1200 CAGGAGCGGC GCTCCCCCAC CACCACGGCG CTCTGCCTCT TCAGAATGAG TGAGATCCAG 1260 GCGCGCGCCA AGAGGGTCAG CTGGGACTTC AAGACGGCCG AGAGCCACTG CAAAGAAGGG 1320 GATCAACCTG AAAGAGTCCA ACCAATCGCA TCATCTACCT TGATCCATTC CGACCTGACA 1380 TCCGTTTATG GCACCGTGGT AATGAACAGG ACTGTTTTAT TCTTGGGGAC TGGAGATGGC 1440 CAGTTACTTA AGGTTATTCT TGGTGAGAAT TTGACTTCAA ATTGTCCAGA GGTTATCTAT 1500 GAAATTAAAG AAGAGACACC TGTTTTCTAC AAACTCGTTC CTGATCCTGT GAAGAATATC 1560 TACATTTATC TAACAGCTGG GAAAGAGGTG AGGAGAATTC GTGTTGCAAA CTGCAATAAA 1620 CATAAATCCT GTTCGGAGTG TTTAACAGCC ACAGACCCTC ACTGCGGTTG GTGCCATTCG 1680 CTACAAAGGT GCACTTTTCA AGGAGATTGT GTACATTCAG AGAACTTAGA AAACTGGCTG 1740 GATATTTCGT CTGGAGCAAA AAAGTGCCCT AAAATTCAGA TAATTCGAAG CAGTAAAGAA 1800 AAGACTACAG TGACTATGGT GGGAAGCTTC TCTCCAAGAC ACTCAAAGTG CATGGTGAAG 1860 AATGTGGACT CTAGCAGGGA GCTCTGCCAG AATAAAAGTC AGCCCAACCG GACCTGCACC 1920 TGTAGCATCC CAACCAGAGC AACCTACAAA GATGTTTCAG TTGTCAACGT GATGTTCTCC 1980 TTCGGTTCTT GGAATTTATC AGACAGATTC AACTTTACCA ACTGCTCATC ATTAAAAGAA 2040 TGCCCAGCAT GCGTAGAAAC TGGCTGCGCG TGGTGTAAAA GTGCAAGAAG GTGTATCCAC 2100 CCCTTCACAG CTTGCGACCC TTCTGATTAT GAGAGAAACC AGGAACAGTG TCCAGTGGCT 2160 GTCGAGAAGA CATCAGGAGG AGGAAGACCC AAGGAGAACA AGGGGAACAG AACCAACCAG 2220 GCTTTACAGG TCTTCTACAT TAAGTCCATT GAGCCACAGA AAGTATCGAC ATTAGGGAAA 2280 AGCAACGTGA TAGTAACGGG AGCAAACTTT ACCCGGGCAT CGAACATCAC AATGATCCTG 2340 AAAGGAACCA GTACCTGTGA TAAGGATGTG ATACAGGTTA GCCATGTGCT AAATGACACC 2400 CACATGAAAT TCTCTCTTCC ATCAAGCCGG AAAGAAATGA AGGATGTGTG TATCCAGTTT 2460 GATGGTGGGA ACTGCTCTTC TGTGGGATCC TTATCCTACA TTGCTCTGCC ACATTGTTCC 2520 CTTATATTTC CTGCTACCAC CTGGATCAGT GGTGGTCAAA ATATAACCAT GATGGGCAGA 2580 AATTTTGATG TAATTGACAA CTTAATCATT TCACATGAAT TAAAAGGAAA CATAAATGTC 2640 TCTGAATATT GTGTGGCGAC TTACTGCGGG TTTTTAGCCC CCAGTTTAAA GAGTTCAAAA 2700 GTGCGCACGA ATGTCACTGT GAAGCTGAGA GTACAAGACA CCTACTTGGA TTGTGGAACC 2760 CTGCAGTATC GGGAGGACCC CAGATTCACG GGGTATCGGG TGGAATCCGA GGTGGACACA 2820 GAACTGGAAG TGAAAATTCA AAAAGAAAAT GACAACTTCA ATATTTCCAA AAAAGACATT 2880 GAAATTACTC TCTTCCATGG GGAAAATGGG CAATTAAATT GCAGTTTTGA AAATATTACT 2940 AGAAATCAAG ATCTTACCAC CATCCTTTGC AAAATTAAAG GCATCAAGAC TGCAAGCACC 3000 ATTGCCAACT CTTCTAAGAA AGTTCGGGTC AAGCTGGGAA ACCTGGAGCT CTACGTCGAG 3060 CAGGAGTCAG TTCCTTCCAC ATGGTATTTT CTGATTGTGC TCCCTGTCTT GCTAGTGATT 3120 GTCATTTTTG CGGCCGTGGG GGTGACCAGG CACAAATCGA AGGAGCTGAG TCGCAAACAG 3180 AGTCAACAAC TAGAATTGCT GGAAAGCGAG CTCCGGAAAG AGATACGTGA CGGCTTTGCT 3240 GAGCTGCAGA TGGATAAATT GGATGTGGTT GATAGTTTTG GAACTGTTCC CTTCCTTGAC 3300 TACAAACATT TTGCTCTGAG AACTTTCTTC CCTGAGTCAG GTGGCTTCAC CCACATCTTC 3360 ACTGAAGATA TGCATAACAG AGACGCCAAC GACAAGAATG AAAGTCTCAC AGCTTTGGAT 3420 GCCCTAATCT GTAATAAAAG CTTTCTTGTT ACTGTCATCC ACACCCTTGA AAAGCAGAAG 3480 AACTTTTCTG TGAAGGACAG GTGTCTGTTT GCCTCCTTCC TAACCATTGC ACTGCAAACC 3540 AAGCTGGTCT ACCTGACCAG CATCCTAGAG GTGCTGACCA GGGACTTGAT GGAACAGTGT 3600 AGTAACATGC AGCCGAAACT CATGCTGAGA CGCACGGAGT CCGTCGTCGA AAAACTCCTC 3660 ACAAACTGGA TGTCCGTCTG CCTTTCTGGA TTTCTCCGGG AGACTGTCGG AGAGCCCTTC 3720 TATTTGCTGG TGACGACTCT GAACCAGAAA ATTAACAAGG GTCCCGTGGA TGTAATCACT 3780 TGCAAAGCCC TGTACACACT TAATGAAGAC TGGCTGTTGT GGCAGGTTCC GGAATTCAGT 3840 ACTGTGGCAT TAAACGTCGT CTTTGAAAAA ATCCCGGAAA ACGAGAGTGC AGATGTCTGT 3900 CGGAATATTT CAGTCAATGT TCTCGACTGT GACACCATTG GCCAAGCCAA AGAAAAGATT 3960

TTCCAAGCAT TCTTAAGCAA AAATGGCTCT CCTTATGGAC TTCAGCTTAA TGAAATTGGT 4020 CTTGAGCTTC AAATGGGCAC ACGACAGAAA GAACTTCTGG ACATCGACAG TTCCTCCGTG 4080 ATTCTTGAAG ATGGAATCAC CAAGCTAAAC ACCATTGGCC ACTATGAGAT ATCAAATGGA 4140 TCCACTATAA AAGTCTTTAA GAAGATAGCA AATTTTACTT CAGATGTGGA GTACTCGGAT 4200 GACCACTGCC ATTTGATTTT ACCAGATTCG GAAGCATTCC AAGATGTGCA AGGAAAGAGA 4260 CATCGAGGGA AGCACAAGTT CAAAGTAAAA GAAATGTATC TGACAAAGCT GCTGTCGACC 4320 AAGGTGGCAA TTCATTCTGT GCTTGAAAAA CTTTTTAGAA GCATTTGGAG TTTACCCAAC 4380 AGCAGAGCTC CATTTGCTAT AAAATACTTT TTTGACTTTT TGGACGCCCA GGCTGAAAAC 4440 AAAAAAATCA CAGATCCTGA CGTCGTACAT ATTTGGAAAA CAAACAGCCT TCCTCTTCGC 4500 TTCTGGGTAA ACATCCTGAA GAACCCTCAG TTTGTCTTTG ACATTAAGAA GACACCACAT 4560 ATAGACGGCT GTTTGTCAGT GATTGCCCAG GCATTCATGG ATGCATTTTC TCTCACAGAG 4620 CAGCAACTAG GGAAGGAAGC ACCAACTAAT AAGCTTCTCT ATGCCAAGGA TATCCCAACC 4680 TACAAAGAAG AAGTAAAATC TTATTACAAA GCAATCAGGG ATTTGCCTCC ATTGTCATCC 4740 TCAGAAATGG AAGAATTTTT AACTCAGGAA TCTAAGAAAC ATGAAAATGA ATTTAATGAA 4800 GAAGTGGCCT TGACAGAAAT TTACAAATAC ATCGTAAAAT ATTTTGATGA GATTCTAAAT 4860 AAACTAGAAA GAGAACGAGG GCTGGAAGAA GCTCAGAAAC AACTCTTGCA TGTAAAAGTC 4920 TTATTTGATG AAAAGAAGAA ATGCAAGTGG ATGTAAGCAC TCTGGGGCCT GGCTTAATCT 4980 GGCAAAGTTC TTCAGACGAC TTGGGAGCAA AATGGCTGCT TGAGCTACTC TGTGTCGTTA 5040 ATTTGTTGTT TGCACATAGG TTCCACTTTG GGCACTGTCT TTTTAAGAGA CCAAGGCACA 5100 TGCACAGCTT TTAGAAAGCA A 5121 Seq ID NO : 169 DNA Sequence Nucleic Acid Accession # : XM 063670. 1 Coding sequence : 1.. 708 1 11 21 31 41 51 1 1 1 1 1 1 ATGCAGAGAA TCCTTGAGGA ACCAGCTGAT GATTGCACAT GGTCAACTCG GATTCTTCTT 60 ACCCTGAGTG AATTTATAAT GTCGCTGCAG CGTACTGTTT ATCCCCACAG TGAGAAGTGG 120 CGTGCTCTCT CAGTCCCTTC ATCTTCCTAT TTTCAGGAGC TGGTGGGCAC CAGCCAGGAA 180 CTGGCTCTCA CCTTCTGGCA TTTACTGTCT ATGTTTGGAT TCTTCATCGT GTCCTATGGC 240 TTTCTCACAG CATTTGGCAG GACTCTTTTC CACTTGGATC TGCTACAACC CAACCTTACA 300 CCTTCACGCT TTGACAAGTA CACTGGTCTC TTCATCTATG AAATAGAGGG AGATGGGTTA 360 GATCCATGTT TTCAAAGCAT GGTCCAAGGA ATCCTAGAGG TTTTGTGGAT GTCCAAAGTG 420 GAGAGTGCAT ACCACACTAA TGATGGTGAT ACTGCTGGAG AGGGGGTGGA AAATGGTACC 480 AGTCAAACCC GAGGCGGAGG AGGAGCAGCC CGCAGTCGCT GCCGCGAGAT GGAGGAGCCC 540 ACGCCCGAGC CCGTCTATGT CGACGTAGAC AAAGGGCTGA CCTTGGCCTG CTTCGTCTTC 600 CTCTGCCTCT TCCTTGTCGT GATGATCATC CGCTGTGCCA AGGTCATCAT GGACCCTTAC 660 AGCGCCATCC CCACATCCAC CTGGGAGGAG CAGCACCTGG ACGACTGA 708 Seq ID NO : 170 DNA Sequence Nucleic Acid Accession # : FGENESH predicted Coding sequence : 1-936 1 11 21 31 41 51 ATGGAGCCAA GCCACAGCCA ACCCACAATG GACATGAAGC ACATGCAAGA GCGTCCAGCT 60 GCCTCGCCTT TAAAATGCCA GGACGGCCGC GGCTCCGCTC AGAGCCCCCT CTCGGCTGCT 120 GGCCCGGGCT CGCCCGCGCC GCTGGGGGCT CTGACTCCTG CCGAGCCGGG CCTGGGCAGC 180 GCCCCCCGCG CCCCGCGAGC CCGCGCCCCC GTCACCGGGA AACGCCGTAG CCGGCGATCC 240 GCGGTCGCCC TGGGCTCGGC GCCGGCCCAG CCAGGACCCC GGGAGCGCAC GGGACGGGCC 300 TCGCCAGCCC TAGAAAATAA CTCTGACCTC TTGTCCAAGG CATCTGCTAT AGCTACTGGG 360 ACACCACCCT GTGAAGACTC TACCATTGCA AGGTTCTACC TGCCCCCACC TCTCACCACT 420 CACCCCGAGC TGGTGGGCAC CAGCCAGGAA CTGGCTCTCA CCTTCTGGCA TTTACTGTCT 480 ATGTTTGGAT TCTTCATCGT GTCCTATGGC TTTCTCACAG CATTTGGCAG GACTCTTTTC 540 CACTTGGATC TGCTACAACC CAACCTTACA CCTTCACGCT TTGACAAGTA CACTGGCCAG 600 CTCCTCGAGC TCCCAGTTCA CTCAAAGTAT GTACTGACCA TCCACTGGAG CCAGGGACTG 660 TGCATTTGGT CGTCACATCC CTGTGAAGCA GGGGTGGAAA ATGGTACCAG TCAAACCCGA 720 GGCGGAGGAG GAGCAGCCCG CAGTCGCTGC CGCGAGATGG AGGAGCCCAC GCCCGAGCCC 780 GTCTATGTCG ACGTAGACAA AGGGCTGACC TTGGCCTGCT TCGTCTTCCT CTGCCTCTTC 840 CTTGTCGTGA TGATCATCCG CTGTGCCAAG GTCATCATGG ACCCTTACAG CGCCATCCCC 900 ACATCCACCT GGGAGGAGCA GCACCTGGAC GACTGA 936 Seq ID NO : 171 DNA Sequence Nucleic Acid Accession # : FGENESH predicted Coding sequence : 1-2094 1 11 21 31 41 51 ATGGGCAAGG ATTTCATGTC TAAAACACCA AAAGCAATGG CAACACAAGC CAAAATTGAC 60 AAATGGGATC TAATTAAACT AAAGAGCTTC TGCACAGCAA AAGAAACTAC CATCAGAGTG 120 AACAGACAAC CTACAGAATG GGAGAAAATT TTTGCAATCT ACTCATCTGA CGAAGGGCTA 180 ATATCCAGAA TCTACAATGA ACCCAAACAA ATTTACAAGA AAAAAACAAA CAACCCTATC 240 AACAAGTGGG CGAAGGATAT GAACAGACAC TTCTCAAAAG AAGACATTTA TGCAGCCAAC 300 AGACACATGA AAAAATGCTC ATCATCACTG GCCATCAGAG AAATGCAAAT CAAAACCACA 360 ACGAGATGCC ATCTCACACC AGTTAGAATG GCGATCATTA AAAAGTCAGG AAACAACAGA 420 ACTGCAGAAG AACAGCCAAA ACTGAGAAAG GAAGCAGTTG GATCTATTGA GATATTCCGC 480 TTTGCTGATG GACTGGACAT CACACTCATG ATCCTGGGTA TACTGGCATC ACTGGTCAAT 540 GGAGCCTGCC TTCCTTTAAT GCCACTGGTT TTAGGAGAAA TGAGTGATAA CCTTATTAGT 600 GGATGTCTAG TCCAAACTAA CACAACAAAT TATCAGAACT GTACTCAGTC TCAAGAGAAG 660 CTGAATGAAG ATATGACTCT GTTGACCCTG TATTATGTTG GAATAGGTGT TGCTGCCTTG 720 ATTTTTGGTT ACATACAGAT TTCCTTGTGG ATTATAACTG CAGCACGACA GACCAAGAGG 780 ATTCGAAAAC AGTTTTTTCA TTCAGTTTTG GCACAGGACA TCGGCTGGTT TGATAGCTGT 840 GACATCGGTG AACTTAACAC TCGCATGACA GATGACATTG ACAAAATCAG TGATGGTATT 900 GGAGATAAGA TTGCTCTGTT GTTTCAAAAC ATGTCTACTT TTTCGATTGG CCTGGCAGTT 960 GGTTTGGTGA AGGGCTGGAA ACTCACCCTA GTGACTCTAT CCACGTCTCC TCTTATAATG 1020 GCTTCAGCGG CAGCATGTTC TAGGATGGTC ATCTCATTGA CCAGTAAGGA ATTAAGTGCC 1080

TATTCCAAAG CTGGGGCTGT GGCAGAAGAA GTCTTGTCAT CAATCCGAAC AGTCATAGCC 1140 TTTAGGGCCC AGGAGAAAGA ACTTCAAAGG TATACACAGA ATCTCAAAGA TGCAAAGGAT 1200 TTTGGCATAA AAAGGACTAT AGCTTCAAAA GTGTCTCTTG GTGCTGTGTA CTTCTTTATG 1260 AATGGAACCT ATGGACTTGC TTTTTGGTAT GGAACCTCCT TGATTCTTAA TGGAGAACCT 1320 GGATATACCA TCGGGACTGT TCTTGCTGTT TTCTTTAGTG TAATCCATAG CAGTTATTGC 1380 ATTGGAGCAG CAGTCCCTCA CTTTGAAACC TTCGCAATAG CCCGAGGAGC TGCCTTTCAT 1440 ATTTTCCAGG TTATTGATAA GAAACCCAGT ATAGATAACT TTTCCACAGC TGGATATAAA 1500 CCTGAATCCA TAGAAGGAAC TGTGGAATTT AAAAATGTTT CTTTCAATTA TCCATCAAGA 1560 CCATCTATCA AGATTCTGAA AGGTCTGAAT CTCAGAATTA AGTCTGGAGA GACAGTCGCC 1620 TTGGTCGGTC TCAATGGCAG TGGGAAGAGT ACGGTAGTCC AGCTTCTGCA GAGGTTATAT 1680 GATCCGGATG ATGGCTTTAT CATGGTGGAT GAGAATGACA TCAGAGCTTT AAATGTGCGG 1740 CATTATCGAG ACCATATTGG AGTGGTTAGT CAAGAGCCTG TTTTGTTCGG GACCACCATC 1800 AGTAACAATA TCAAGTATGG ACGAGATGAT GTGACTGATG AAGAGATGGA GAGAGCAGCA 1860 AGGGAAGCAA ATGCGTATGA TTTTATCATG GAGTTTCCTA ATAAATTTAA TACATTGGTA 1920 GGGGAAAAAG GAGCTCAAAT GAGTGGAGGG CAGAAACAGA GGATCGCAAT TGCTCGTGCC 1980 TTAGTTCGAA ACCCCAAGAT TCTGATTTTA GATGAGGCTA CGTCTGCCCT GGATTCAGAA 2040 AGCAAGTCAG CTGTTCAAGC TGCACTGGAG AAGGATACCC CCAGGTATTC ATTTTGA 2097 Seq ID NO : 172 DNA Sequence Nucleic Acid Accession # : XM166496. 1 Coding sequence : 378.. 773 1 11 21 31 41 51 CCTAATTCCT CTAATATCTC TCTGTTTTCT TTAGTGTAAT CCATAGCAGT TATTGCATTG 60 GAGCAGCAGT CCCTCACTTT GAAACCTTCG CAATAGCCCG AGGAGCTGCC TTTCATATTT 120 TCCAGGTTAT TGATAAGAAA CCCAGTATAG ATAACTTTTC CACAGCTGGA TATAAACCTG 180 AATCCATAGA AGGAACTGTG GAATTTAAAA ATGTTTCTTT CAATTATCCA TCAAGACCAT 240 CTATCAAGAT TCTGAAAGGT CTGAATCTCA GAATTAAGTC TGGAGAGACA GTCGCCTTGG 300 TCGGTCTCAA TGGCAGTGGG AAGAGTACGG TAGTCCAGCT TCTGCAGAGG TTATATGATC 360 CGGATGATGG CTTTATCATG GTGGATGAGA ATGACATCAG AGCTTTAAAT GTGCGGCATT 420 ATCGAGACCA TATTGGAGTG GTTAGTCAAG AGCCTGTTTT GTTCGGGACC ACCATCAGTA 480 ACAATATCAA GTATGGACGA GATGATGTGA CTGATGAAGA GATGGAGAGA GCAGCAAGGG 540 AAGCAAATGC GTATGATTTT ATCATGGAGT TTCCTAATAA ATTTAATACA TTGGTAGGGG 600 AAAAAGGAGC TCAAATGAGT GGAGGGCAGA AACAGAGGAT CGCAATTGCT CGTGCCTTAG 660 TTCGAAACCC CAAGATTCTG ATTTTAGATG AGGCTACGTC TGCCCTGGAT TCAGAAAGCA 720 AGTCAGCTGT TCAAGCTGCA CTGGAGAAGG ATACCCCCAG GTATTCATTT TGACCTAATT 780 TCACCTCAAG TGGAGAATCG CTGACCTTGA ACCAGCGCCC TTCGACAGCT CTGGCCCCTC 840 AAACCTCACC CTGACCTCCT GCTGCCTATG AGCTACTG 878 Seq ID NO : 173 DNA Sequence Nucleic Acid Accession # : XM166305. 2 Coding sequence : 157.. 1104 1 11 21 31 41 51 ( GAGAAGCCCT CTTCCCTTTA AAAAAAAAAA AAAAAAGGCT GCTTCTCGCA GAGTGGAAAG 60 CCCCGGTCCC CATCCCACCA AAACCATTTG ACAAGCAGGA CAACGAAGAG GCAGAAGGAT 120 CTGGGCCTGT GCGCGACGCC CCGGGGGACG AGGCTCATGG AGAAGTTTCG GGCGGTGCTG 180 GACCTGCACG TCAAGCACCA CAGCGCCTTG GGCTACGGCC TGGTGACCCT GCTGACGGCG 240 GGCGGGGAGC GCATCTTCTC CGCCGTGGCA TTCCAGTGCC CGTGCAGCGC CGCCTGGAAC 300 CTGCCCTACG GCCTGGTCTT CTTGCTGGTG CCGGCGCTCG CGCTCTTCCT CCTGGGCTAC 360 GTGCTGAGCG CACGCACGTG GCGCCTGCTC ACCGGATGCT GCTCCAGCGC CCGCGCGAGT 420 TGCGGATCGG CGCTGCGCGG CTCCCTGGTG TGCACGCAAA TCAGCGCGGC CGCCGCGCTC 480 GCGCCCCTCA CCTGGGTGGC CGTGGCGCTG CTCGGGGGCG CCTTTTACGA GTGCGCGGCC 540 ACCGGGAGCG CGGCCTTCGC GCAGCGCCTG TGCCTCGGCC GCAACCGCAG CTGCGCCGCG 600 GAGCTGCCGC TGGTGCCGTG CAACCAGGCC AAGGCGTCGG ACGTGCAGGA CCTCCTGAAG 660 GATCTGAAGG CTCAGTCGCA GGTGTTGGGC TGGATCTTGA TAGCAGTTGT TATCATCATT 720 CTTCTGATTT TTACATCTGT CACCCGATGC CTATCTCCAG TTAGTTTTCT GCAGCTGAAA 780 TTCTGGAAAA TCTATTTGGA ACAGGAGCAG CAGATCCTTA AAAGTAAAGC CACAGAGCAT 840 GCAACTGAAT TGGCAAAAGA GAATATTAAA TGTTTCTTTG AGGGCTCGCA TCCAAAAGAA 900 TATAACACTC CAAGCATGAA AGAGTGGCAG CAAATTTCAT CACTGTATAC TTTCAATCCG 960 AAGGGCCAGT ACTACAGCAT GTTGCACAAA TATGTCAACA GAAAAGAGAA GACTCACAGT 1020 ATCAGGTCTA CTGAAGGAGA TACGGTGATT CCTGTTCTTG GCTTTGTAGA TTCATCTGGT 1080 ATAAACAGCA CTCCTGAGTT ATGACCTTTT GAATGAGTAG AAAAAAAAAT TGTTTTGAAT 1140 TATTGCTTTA TTAAAAAATA AACATTGGTA TTTTT 1175 Seq ID NO : 174 DNA Sequence Nucleic Acid Accession # : NM_ 032211. 5 Coding sequence : 152.. 2422 1 11 21 31 41 51 ( GGCTGGGGGG CCGCGGGCGG GAGGCGGATA AAAAGGCCCC AGGGCGCCCG GGGAGGGAGC 60 CCGTTAGCGC TGCTCCGCCG CGGCGCCCGC CCAGCCCCGG ACTGTCCGCG CTCCATCTGG 120 TATCTTGGCC TCAGCTGTCC TTGAAGTCAC CATGGCGAGG TCCCCACCAG CCACCCTCTT 180 TCTGTTCCTG CTGCTGCTAG GCCAGCCCCC TCCCAGCAGG CCACAGTCAC TGGGCACCAC 240 TAAGCTCCGG CTGGTGGGCC CAGAGAGCAA GCCAGAGGAG GGCCGCCTGG AGGTGCTGCA 300 CCAGGGCCAG TGGGGCACCG TGTGTGATGA CAACTTTGCT ATCCAGGAGG CCACAGTGGC 360 TTGCCGCCAG CTGGGCTTCG AAGCTGCCTT GACCTGGGCC CACAGTGCCA AGTACGGCCA 420 AGGGGAGGGA CCCATCTGGC TGGACAATGT GCAGTGTGTG GGCACAGAGA GCTCCTTGGA 480 CCAGTGCGGG TCTAATGGCT GGGGAGTCAG TGACTGCAGT CACTCAGAAG ACGTAGGGGT 540 GATATGCCAC CCCCGGCGCC ATCGTGGCTA CCTTTCTGAA ACTGTCTCCA ATGCCCTTGG 600 GCCCCAGGGC CGGCGGCTGG AGGAGGTGCG GCTCAAGCCC ATCCTTGCCA GTGCCAAGCA 660 GCATAGCCCA GTGACCGAGG GAGCCGTGGA GGTGAAGTAT GAGGGCCACT GGCGGCAGGT 720 GTGTGACCAG GGCTGGACCA TGAACAACAG CAGGGTGGTG TGCGGGATGC TGGGCTTCCC 780 CAGCGAGGTG CCTGTCGACA GCCACTACTA CAGGAAAGTC TGGGATCTGA AGATGAGGGA 840

CCCTAAGTCT AGGCTGAAGA GCCTGACGAA TAAGAACTCC TTCTGGATCC ACCAGGTCAC 900 CTGCCTGGGG ACAGAGCCCC ACATGGCCAA CTGCCAGGTG CAGGTGGCTC CAGCCCGGGG 960 CAAGCTGCGG CCAGCCTGCC CAGGTGGCAT GCATGCTGTG GTCAGCTGTG TGGCAGGGCC 1020 TCACTTCCGC CCACCGAAGA CAAAGCCACA ACGCAAAGGG TCCTGGGCAG AGGAGCCGAG 1080 GGTGCGCCTG CGCTCCGGGG CCCAGGTGGG CGAGGGCCGG GTGGAAGTGC TCATGAACCG 1140 CCAGTGGGGC ACGGTCTGTG ACCACAGGTG GAACCTCATC TCTGCCAGTG TCGTGTGTCG 1200 TCAGCTGGGC TTTGGCTCTG CTCGGGAGGC CCTCTTTGGG GCCCGGCTGG GCCAAGGGCT 1260 AGGGCCCATC CACCTGAGTG AGGTGCGCTG CAGGGGATAT GAGCGGACCC TCAGCGACTG 1320 CCCTGCCCTG GAAGGGTCCC AGAATGGTTG CCAACATGAG AATGCTGCTG CTGTCAGGTG 1380 CAATGTCCCT AACATGGGCT TTCAGAATCA GGTGCGCTTG GCTGGTGGGC GTATCCCTGA 1440 GGAGGGGCTA TTGGAGGTGC AGGTGGAGGT GAACGGGGTC CCACGCTGGG GGAGCGTGTG 1500 CAGTGAAAAC TGGGGGCTCA CCGAAGCCAT GGTGGCCTGC CGACAGCTCG GCCTGGGTTT 1560 TGCCATCCAT GCCTACAAGG AAACCTGGTT CTGGTCGGGG ACGCCAAGGG CCCAGGAGGT 1620 GGTGATGAGT GGGGTGCGCT GCTCAGGCAC AGAGCTGGCC CTGCAGCAGT GCCAGAGGCA 1680 CGGGCCGGTG CACTGCTCCC ACGGTGGCGG GCGCTTCCTG GCTGGAGTCT CCTGCATGGA 1740 CAGTGCACCA GACCTGGTGA TGAACGCCCA GCTAGTGCAG GAGACGGCCT ACTTGGAGGA 1800 CCGCCCGCTC AGCCAGCTGT ATTGTGCCCA CGAGGAGAAC TGCCTCTCCA AGTCTGCGGA 1860 TCACATGGAC TGGCCCTACG GATACCGCCG CCTATTGCGC TTCTCCACAC AGATCTACAA 1920 TCTGGGCCGG ACTGACTTTC GTCCAAAGAC TGGACGCGAT AGCTGGGTTT GGCACCAGTG 1980 CCACAGGCAT TACCACAGCA TTGAGGTCTT CACCCACTAC GACCTCCTCA CTCTCAATGG 2040 CTCCAAGGTG GCTGAGGGGC ACAAGGCCAG CTTCTGTCTG GAGGACACAA ACTGCCCCAC 2100 AGGACTGCAG CGGCGCTACG CATGTGCCAA CTTTGGAGAA CAGGGAGTGA CTGTAGGCTG 2160 CTGGGACACC TACCGGCATG ACATTGATTG CCAGTGGGTG GATATCACAG ATGTGGGCCC 2220 CGGGAATTAT ATCTTCCAGG TGATTGTGAA CCCCCACTAT GAAGTGGCAG AGTCAGATTT 2280 CTCCAACAAT ATGCTGCAGT GCCGCTGCAA GTATGATGGG CACCGGGTCT GGCTGCACAA 2340 CTGCCACACA GGGAATTCAT ACCCAGCCAA TGCAGAACTC TCCCTGGAGC AGGAACAGCG 2400 TCTCAGGAAC AACCTCATCT GAAGCTGTCA CTGCACACTC CTAGCTGCTG CCGATACACC 2460 AGATACCTCA GCTTATTGGA GCCATGCCCT TCACAGAGTC CCAACTCAGA GGAAAAGGGC 2520 CAGTGCCAAG GGGCACCAAG AACCTGCTCA GGAAGCCTTT TGATGGCAAG ATCACCAATC 2580 CAGATGGTAT TGCTCCCTCA GGATGGCTCT GGGCCTGCCC CTAAGGGCCT GTGGCCTATG 2640 GAATATGTCC TCCAGGCTTT GCTCAGCTGA GCTCCTCTTC TGTAAGGAAA CCCAGTCATC 2700 CCTGAATCTT GCCACAGAGA TCCGGGATTC AGGAGCTCTC AGTTTCTTAG GGATGGACTA 2760 TGGCCCAGTC CCCCATCTAA GTGGTGCTTT GCAAATGTCT TGGAGGAGTA TAGGACAGAG 2820 GACCAAAATA CACAGCAGGT AGTGTTAGCT CTCTGCTAGG AGCTCAAAGC AACACAACTT 2880 GTATCAAAAT CACAACTGGC AGAGAAGCTG GTGGATCCAA TCCTTTCTTC ATCTGTTGTT 2940 ATTTAGAACT CACCTCTCAC ACTCTGTTCT TTAGTGTCCT TACCTTTATC TTACCACACA 3000 CATGGGTGTT TCTATTATCC TTGGAAGCAC AGACCTCGGG CATCCCCTTA TTGCCTGATG 3060 GGCCAACACC AACAGTTACG GAGTGCTTGA GAAGGGCCAA GTTTCACAGA AATGGCCAGA 3120 TAGGGCCTTC CTACAGAGCA GCAAGAGTAG GCCAAGCAGA AAGACTGCTG AGGTAACACG 3180 GACCCCAGCC CCTGTCAGGG CCTCTGCCAA GGAAATAATA TGGACCATTT ACCTGGCAGG 3240 CAGTCTGCTC TCTCTCAGGA TCACCACGCA TCTCAGGATT GGTCTAAACT TCAAGTCTCA 3300 ACCAAGTGTC TGAAGTGAAC TTTGCATTGA ATAAATTTTT GCCATGGAAA GAACATCAAA 3360 CAAGCCACTC ATCTCTACAG AGATAAGAAA ACAAGTTTGG CAGAGCAAGA GACAGAAGAC 3420 CGTGGAGAAA TCAGAAGGGG GAACAGTCAG TTTAGTTAAG GATGGAACCT GGGAAAGGCC 3480 ACCATTCCTG CTTGATGGGG CTCTGATTTG CTCTTGCTCA AGTGGAATAA AACCCCATGG 3540 TCTTCTTGAC ATGATTCTTG ATCTTTTCTC CACTGAGACA CACTTAAGTG ATGATCCTTA 3600 CAGGACTGAC ACCCTAATGC CAATAAAAGT TGCTCATTAT GGACTGCTAC AAAAAAAAAA 3660 AAAAA 3665 Seq ID NO : 175 DNA Sequence Nucleic Acid Accession # : NM001798. 2 Coding sequence : 234.. 1130 1 11 21 31 41 51 1 1 1 1 1 1 GGAAGCAGGG CGGGGCCTCT GGTGGCGGTC GGGAACTCGG TGGGAGGCGG CAACATTGTT 60 TCAAGTTGGC CAAATTGACA AGAGCGAGAG GTATACTGCG TTCCATCCCG ACCCGGGGCC 120 ACGGTACTGG GCCCTGTTTC CCCCTCCTCG GCCCCCGAGA GCCAGGGTCC GCCTTCTGCA 180 GGGTTCCCAG GCCCCCGCTC CAGGGCCGGG CTGACCCGAC TCGCTGGCGC TTCATGGAGA 240 ACTTCCAAAA GGTGGAAAAG ATCGGAGAGG GCACGTACGG AGTTGTGTAC AAAGCCAGAA 300 ACAAGTTGAC GGGAGAGGTG GTGGCGCTTA AGAAAATCCG CCTGGACACT GAGACTGAGG 360 GTGTGCCCAG TACTGCCATC CGAGAGATCT CTCTGCTTAA GGAGCTTAAC CATCCTAATA 420 TTGTCAAGCT GCTGGATGTC ATTCACACAG AAAATAAACT CTACCTGGTT TTTGAATTTC 480 TGCACCAAGA TCTCAAGAAA TTCATGGATG CCTCTGCTCT CACTGGCATT CCTCTTCCCC 540 TCATCAAGAG CTATCTGTTC CAGCTGCTCC AGGGCCTAGC TTTCTGCCAT TCTCATCGGG 600 TCCTCCACCG AGACCTTAAA CCTCAGAATC TGCTTATTAA CACAGAGGGG GCCATCAAGC 660 TAGCAGACTT TGGACTAGCC AGAGCTTTTG GAGTCCCTGT TCGTACTTAC ACCCATGAGG 720 TGGTGACCCT GTGGTACCGA GCTCCTGAAA TCCTCCTGGG CTGCAAATAT TATTCCACAG 780 CTGTGGACAT CTGGAGCCTG GGCTGCATCT TTGCTGAGAT GGTGACTCGC CGGGCCCTAT 840 TCCCTGGAGA TTCTGAGATT GACCAGCTCT TCCGGATCTT TCGGACTCTG GGGACCCCAG 900 ATGAGGTGGT GTGGCCAGGA GTTACTTCTA TGCCTGATTA CAAGCCAAGT TTCCCCAAGT 960 GGGCCCGGCA AGATTTTAGT AAAGTTGTAC CTCCCCTGGA TGAAGATGGA CGGAGCTTGT 1020 TATCGCAAAT GCTGCACTAC GACCCTAACA AGCGGATTTC GGCCAAGGCA GCCCTGGCTC 1080 ACCCTTTCTT CCAGGATGTG ACCAAGCCAG TACCCCATCT TCGACTCTGA TAGCCTTCTT 1140 GAAGCCCCCA GCCCTAATCT CACCCTCTCC TCCAGTGTGG GCTTGACCAG GCTTGGCCTT 1200 GGGCTATTTG GACTCAGGTG GGCCCTCTGA ACTTGCCTTA AACACTCACC TTCTAGTCTT 1260 GGCCAGCCAA CTCTGGGAAT ACAGGGGTGA AAGGGGGGAA CCAGTGAAAA TGAAAGGAAG 1320 TTTCAGTATT AGATGCACTT AAGTTAGCCT CCACCACCCT TTCCCCCTTC TCTTAGTTAT 1380 TGCTGAAGAG GGTTGGTATA AAAATAATTT TAAAAAAGCC TTCCTACACG TTAGATTTGC 1440 CGTACCAATC TCTGAATGCC CCATAATTAT TATTTCCAGT GTTTGGGATG ACCAGGATCC 1500 CAAGCCTCCT GCTGCCACAA TGTTTATAAA GGCCAAATGA TAGCGGGGGC TAAGTTGGTG 1560 CTTTTGAGAA CCAAGTAAAA CAAAACCACT GGGAGGAGTC TATTTTAAAG AATTCGGTTG 1620 AAAAAATAGA TCCAATCAGT TTATACCCTA GTTAGTGTTT TGCCTCACCT AATAGGCTGG 1680 GAGACTGAAG ACTCAGCCCG GGTGGGGCTG CAGAAAAATG ATTGGCCCCA GTCCCCTTGT 1740 TTGTCCCTTC TACAGGCATG AGGAATCTGG GAGGCCCTGA GACAGGGATT GTGCTTCATT 1800

CCAATCTATT GCTTCACCAT GGCCTTATGA GGCAGGTGAG AGATGTTTGA ATTTTTCTCT 1860 TCCTTTTAGT ATTCTTAGTT GTTCAGTTGC CAAGGATCCC TGATCCCATT TTCCTCTGAC 1920 GTCCACCTCC TACCCCATAG GAGTTAGAAG TTAGGGTTTA GGCATCATTT TGAGAATGCT 1980 GACACTTTTT CAGGGCTGTG ATTGAGTGAG GGCATGGGTA AAAATATTTC TTTAAAAGAA 2040 GGATGAACAA TTATATTTAT ATTTCAGGTT ATATCCAATA GTAGAGTTGG CTTTTTTTTT 2100 TTTTTTTTTG GTCATAGTGG GTGGATTTGT TGCCATGTGC ACCTTGGGGT TTTGTAATGA 2160 CAGTGCTAAA AAAAAAAAAG CATTTTTTTT TATGATTTGT CTCTGTCACC CTTGTCCTTG 2220 AGTGCTCTTG CTATTAACGT TATTTGTAAT TTAGTTTGTA GCTCATTAAA AAAATGTGCC 2280 TAGTTTTATA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAA 2328 Seq ID NO : 176 DNA Sequence Nucleic Acid Accession # : Nom 052827. 1 Coding sequence : 234.. 1028 1 11 21 31 41 51 ( GGAAGCAGGG CGGGGCCTCT GGTGGCGGTC GGGAACTCGG TGGGAGGCGG CAACATTGTT 60 TCAAGTTGGC CAAATTGACA AGAGCGAGAG GTATACTGCG TTCCATCCCG ACCCGGGGCC 120 ACGGTACTGG GCCCTGTTTC CCCCTCCTCG GCCCCCGAGA GCCAGGGTCC GCCTTCTGCA 180 GGGTTCCCAG GCCCCCGCTC CAGGGCCGGG CTGACCCGAC TCGCTGGCGC TTCATGGAGA 240 ACTTCCAAAA GGTGGAAAAG ATCGGAGAGG GCACGTACGG AGTTGTGTAC AAAGCCAGAA 300 ACAAGTTGAC GGGAGAGGTG GTGGCGCTTA AGAAAATCCG CCTGGACACT GAGACTGAGG 360 GTGTGCCCAG TACTGCCATC CGAGAGATCT CTCTGCTTAA GGAGCTTAAC CATCCTAATA 420 TTGTCAAGCT GCTGGATGTC ATTCACACAG AAAATAAACT CTACCTGGTT TTTGAATTTC 480 TGCACCAAGA TCTCAAGAAA TTCATGGATG CCTCTGCTCT CACTGGCATT CCTCTTCCCC 540 TCATCAAGAG CTATCTGTTC CAGCTGCTCC AGGGCCTAGC TTTCTGCCAT TCTCATCGGG 600 TCCTCCACCG AGACCTTAAA CCTCAGAATC TGCTTATTAA CACAGAGGGG GCCATCAAGC 660 TAGCAGACTT TGGACTAGCC AGAGCTTTTG GAGTCCCTGT TCGTACTTAC ACCCATGAGG 720 TGACTCGCCG GGCCCTATTC CCTGGAGATT CTGAGATTGA CCAGCTCTTC CGGATCTTTC 780 GGACTCTGGG GACCCCAGAT GAGGTGGTGT GGCCAGGAGT TACTTCTATG CCTGATTACA 840 AGCCAAGTTT CCCCAAGTGG GCCCGGCAAG ATTTTAGTAA AGTTGTACCT CCCCTGGATG 900 AAGATGGACG GAGCTTGTTA TCGCAAATGC TGCACTACGA CCCTTACAAG AGGATTTCGG 960 CCAAGGCAGC CCTGGCTCAC CCTTTCTTCC AGGATGTGAC CAAGCCAGTA CCCCATCTTC 1020 GACTCTGATA GCCTTCTTGA AGCCCCCAGC CCTAATCTCA CCCTCTCCTC CAGTGTGGGC 1080 TTGACCAGGC TTGGCCTTGG GCTATTTGGA CTCAGGTGGG CCCTCTGAAC TTGCCTTAAA 1140 CACTCACCTT CTAGTCTTGG CCAGCCAACT CTGGGAATAC AGGGGTGAAA GGGGGGAACC 1200 AGTGAAAATG AAAGGAAGTT TCAGTATTAG ATGCACTTAA GTTAGCCTCC ACCACCCTTT 1260 CCCCCTTCTC TTAGTTATTG CTGAAGAGGG TTGGTATAAA AATAATTTTA AAAAAGCCTT 1320 CCTACACGTT AGATTTGCCG TACCAATCTC TGAATGCCCC ATAATTATTA TTTCCAGTGT 1380 TTGGGATGAC CAGGATCCCA AGCCTCCTGC TGCCACAATG TTTATAAAGG CCAAATGATA 1440 GCGGGGGCTA AGTTGGTGCT TTTGAGAACC AAGTAAAACA AAACCACTGG GAGGAGTCTA 1500 TTTTAAAGAA TTCGGTTGAA AAAATAGATC CAATCAGTTT ATACCCTAGT TAGTGTTTTG 1560 CCTCACCTAA TAGGCTGGGA GACTGAAGAC TCAGCCCGGG TGGGGCTGCA GAAAAATGAT 1620 TGGCCCCAGT CCCCTTGTTT GTCCCTTCTA CAGGCATGAG GAATCTGGGA GGCCCTGAGA 1680 CAGGGATTGT GCTTCATTCC AATCTATTGC TTCACCATGG CCTTATGAGG CAGGTGAGAG 1740 ATGTTTGAAT TTTTCTCTTC CTTTTAGTAT TCTTAGTTGT TCAGTTGCCA AGGATCCCTG 1800 ATCCCATTTT CCTCTGACGT CCACCTCCTA CCCCATAGGA GTTAGAAGTT AGGGTTTAGG 1860 CATCATTTTG AGAATGCTGA CACTTTTTCA GGGCTGTGAT TGAGTGAGGG CATGGGTAAA 1920 AATATTTCTT TAAAAGAAGG ATGAACAATT ATATTTATAT TTCAGGTTAT ATCCAATAGT 1980 AGAGTTGGCT TTTTTTTTTT TTTTTTTGGT CATAGTGGGT GGATTTGTTG CCATGTGCAC 2040 CTTGGGGTTT TGTAATGACA GTGCTAAAAA AAAAAAAGCA TTTTTTTTTA TGATTTGTCT 2100 CTGTCACCCT TGTCCTTGAG TGCTCTTGCT ATTAACGTTA TTTGTAATTT AGTTTGTAGC 2160 TCATTAAAAA AATGTGCCTA GTTTTATAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 2220 AAAAAA 2226 Seq ID NO : 177 DNA Sequence Nucleic Acid Accession # : Nom 032738. 1 Coding sequence : 118.. 1197 1 11 21 31 41 51 1 1 1 1 1 1 GGCACGAGGG ATGCAAGGAG ATGAGACAGT TAGATTTACT TCCTCTTTTC TAATCTGAGA 60 GGTTTCATGT TGAAGAAAAT CAGTGTTGGG GTTGCAGGAG ACCTAAACAC AGTCACCATG 120 AAGCTGGGCT GTGTCCTCAT GGCCTGGGCC CTCTACCTTT CCCTTGGTGT GCTCTGGGTG 180 GCCCAGATGC TACTGGCTGC CAGTTTTGAG ACGCTGCAGT GTGAGGGACC TGTCTGCACT 240 GAGGAGAGCA GCTGCCACAC GGAGGATGAC TTGACTGATG CAAGGGAAGC TGGCTTCCAG 300 GTCAAGGCCT ACACTTTCAG TGAACCCTTC CACCTGATTG TGTCCTATGA CTGGCTGATC 360 CTCCAAGGTC CAGCCAAGCC AGTTTTTGAA GGGGACCTGC TGGTTCTGCG CTGCCAGGCC 420 TGGCAAGACT GGCCACTGAC TCAGGTGACC TTCTACCGAG ATGGCTCAGC TCTGGGTCCC 480 CCCGGGCCTA ACAGGGAATT CTCCATCACC GTGGTACAAA AGGCAGACAG CGGGCACTAC 540 CACTGCAGTG GCATCTTCCA GAGCCCTGGT CCTGGGATCC CAGAAACAGC ATCTGTTGTG 600 GCTATCACAG TCCAAGAACT GTTTCCAGCG CCAATTCTCA GAGCTGTACC CTCAGCTGAA 660 CCCCAAGCAG GAAGCCCCAT GACCCTGAGT TGTCAGACAA AGTTGCCCCT GCAGAGGTCA 720 GCTGCCCGCC TCCTCTTCTC CTTCTACAAG GATGGAAGGA TAGTGCAAAG CAGGGGGCTC 780 TCCTCAGAAT TCCAGATCCC CACAGCTTCA GAAGATCACT CCGGGTCATA CTGGTGTGAG 840 GCAGCCACTG AGGACAACCA AGTTTGGAAA CAGAGCCCCC AGCTAGAGAT CAGAGTGCAG 900 GGTGCTTCCA GCTCTGCTGC ACCTCCCACA TTGAATCCAG CTCCTCAGAA ATCAGCTGCT 960 CCAGGAACTG CTCCTGAGGA GGCCCCTGGG CCTCTGCCTC CGCCGCCAAC CCCATCTTCT 1020 GAGGATCCAG GCTTTTCTTC TCCTCTGGGG ATGCCAGATC CTCATCTGTA TCACCAGATG 1080 GGCCTTCTTC TCAAACACAT GCAGGATGTG AGAGTCCTCC TCGGTCACCT GCTCATGGAG 1140 TTGAGGGAAT TATCTGGCCA CCAGAAGCCT GGGACCACAA AGGCTACTGC TGAATAGAAG 1200 TAAACAGTTC ATCCATGATC TCACTTAACC ACCCCAATAA ATCTGATTCT TTATTTTCTC 1260 TTCCTGTCCT GCACATATGC ATAAGTACTT TTACAAGTTG TCCCAGTGTT TTGTTAGAAT 1320 AATGTAGTTA GGTGAGTGTA AATAAATTTA TATAAAGTGA GAATTAGAGT TTAGCTATAA 1380 TTGTGTATTC TCTCTTAACA CAACAGAATT CTGCTGTCTA GATCAGGAAT TTCTATCTGT 1440 TATATCGACC AGAATGTTGT GATTTAAAGA GAACTAATGG AAGTGGATTG AATACAGCAG 1500

TCTCAACTGG GGGCAATTTT GCCCCCCAGA GGACATTGGG CAATGTTTGG AGACATTTTG 1560 GTCATTATAC TTGGGGGGTT GGGGGATGGT GGGATGTGTG TGCTACTGGC ATCCAGTAAA 1620 TAGAAGCCAG GGGTGCCGCT AAACATCCTA TAATGCACAG GGCAGTACCC CACAACGAAA 1680 AATAATCTGG CCCAAAATGT CAGTTGTACT GAGTTTGAGA AACCCCAGCC TAATGAAACC 1740 CTAGGTGTTG GGCTCTGGAA TGGGACTTTG TCCCTTCTAA TTATTATCTC TTTCCAGCCT 1800 CATTCAGCTA TTCTTACTGA CATACCAGTC TTTAGCTGGT GCTATGGTCT GTTCTTTAGT 1860 TCTAGTTTGT ATCCCCTCAA AAGCCATTAT GTTGAAATCC TAATCCCCAA GGTGATGGCA 1920 TTAAGAAGTG GGCCTTTGGG AAGTGATTAG ATCAGGAGTG CAGAGCCCTC ATGATTAGGA 1980 TTAGTGCCCT TATTTAAAAA GGCCCCAGAG AGCTAACTCA CCCTTCCACC ATATGAGGAC 2040 GTGGCAAGAA GATGACATGT ATGAGAACCA AAAAACAGCT GTCGCCAAAC ACCGACTCTG 2100 TCGTTGCCTT GATCTTGAAC TTCCAGCCTC CAGAACTATG AGAAATAAAA TTCTGTTGTT 2160 TGTAAAAAAA AAAAAAAAAA A 2181 Seq ID NO : 178 DNA Sequence Nucleic Acid Accession # : NM _002346. 1 Coding sequence : 136.. 531 1 11 21 31 41 51 GCTCCGGCCA GCCGCGGTCC AGAGCGCGCG AGGTTCGGGG AGCTCCGCCA GGCTGCTGGT 60 ACCTGCGTCC GCCCGGCGAG CAGGACAGGC TGCTTTGGTT TGTGACCTCC AGGCAGGACG 120 GCCATCCTCT CCAGAATGAA GATCTTCTTG CCAGTGCTGC TGGCTGCCCT TCTGGGTGTG 180 GAGCGAGCCA GCTCGCTGAT GTGCTTCTCC TGCTTGAACC AGAAGAGCAA TCTGTACTGC 240 CTGAAGCCGA CCATCTGCTC CGACCAGGAC AACTACTGCG TGACTGTGTC TGCTAGTGCC 300 GGCATTGGGA ATCTCGTGAC ATTTGGCCAC AGCCTGAGCA AGACCTGTTC CCCGGCCTGC 360 CCCATCCCAG AAGGCGTCAA TGTTGGTGTG GCTTCCATGG GCATCAGCTG CTGCCAGAGC 420 TTTCTGTGCA ATTTCAGTGC GGCCGATGGC GGGCTGCGGG CAAGCGTCAC CCTGCTGGGT 480 GCCGGGCTGC TGCTGAGCCT GCTGCCGGCC CTGCTGCGGT TTGGCCCCTG ACCGCCCAGA 540 CCCTGTCCCC CGATCCCCCA GCTCAGGAAG GAAAGCCCAG CCCTTTCTGG ATCCCACAGT 600 GTATGGGAGC CCCTGACTCC TCACGTGCCT GATCTGTGCC CTTGGTCCCA GGTCAGGCCC 660 ACCCCCTGCA CCTCCACCTG CCCCAGCCCC TGCCTCTGCC CAAGTGGGCC AGCTGCCCTC 720 ACTTCTGGGG TGGATGATGT GACCTTCCTT GGGGGACTGC GGAAGGGACG AGGGTTCCCT 780 GGAGTCTTAC GGTCCAACAT CAGACCAAGT CCCATGGACA TGCTGACAGG GTCCCCAGGG 840 AGACCGTGTC AGTAGGGATG TGTGCCTGGC TGTGTACGTG GGTGTGCAGT GCACGTGAGA 900 GCACGTGGCG GCTTCTGGGG GCCATGTTTG GGGAGGGAGG TGTGCCAGCA GCCTGGAGAG 960 CCTCAGTCCC TGTAGCCCCC TGCCCTGGCA CAGCTGCATG CACTTCAAGG GCAGCCTTTG 1020 GGGGTTGGGG TTTCTGCCAC TTCCGGGTCT AGGCCCTGCC CAAATCCAGC CAGTCCTGCC 1080 CCAGCCCACC CCCACATTGG AGCCCTCCTG CTGCTTTGGT GCCTCAAATA AATACAGATG 1140 TCCCC 1145 Seq ID NO : 179 DNA Sequence Nucleic Acid Accession # : XM 113526. 2 Coding sequence : 253.. 2409 1 11 21 31 41 51 TGGGCGCCGG CGGAGCGGAG GGAGATCCGA GCGGCGGCGG CAAGCTGGCT GCGAGCGGCT 60 GAGCAGCACT CCAAGCTCGC CGGCCTTTGG TCTCCAGGAC TTGTCCCAGC AGCCCCTCGA 120 ACTGAGAATT ACACCATCGG ACCCCTGGCT CTGAGGCCTT CAGACTTGGA CTGTGTCACA 180 CTGCCAGGCT TCCAGGGCTC CAACTTGCAG ACGGCCTGTT GTGGGACAGT CTCTGTAATC 240 GCGAAAGCAA CCATGGAAGA CCTGGGGGAA AACACCATGG TTTTATCCAC CCTGAGATCT 300 TTGAACAACT TCATCTCTCA GCGTGTGGAG GGAGGCTCTG GACTGGATAT TTCTACCTCG 360 GCCCCAGGTT CTCTGCAGAT GCAGTACCAG CAGAGCATGC AGCTGGAGGA AAGAGCAGAG 420 CAGATCCGTT CGAAGTCCCA CCTCATCCAG GTGGAGCGGG AGAAAATGCA GATGGAGCTG 480 AGTCACAAGA GGGCTCGAGT GGAGCTGGAG AGAGCAGCCA GCACCAGTGC CAGGAACTAC 540 GAGCGTGAGG TCGACCGCAA CCAGGAGCTC CTGACGCGCA TCCGGCAGCT TCAGGAGCGG 600 GAGGCCGGGG CGGAGGAGAA GATGCAGGAG CAGCTGGAGC GCAACAGGCA GTGTCAGCAG 660 AACTTGGATG CTGCCAGCAA GAGGCTGCGT GAGAAAGAGG ACAGTCTGGC CCAGGCTGGC 720 GAGACCATCA ACGCACTGAA GGGGAGGATC TCGGAACTGC AGTGGAGCGT GATGGACCAG 780 GAGATGCGGG TGAAGCGCCT GGAGTCGGAG AAGCAGGAGC TGCAGGAGCA GCTGGACCTG 840 CAACACAAAA AATGCCAGGA AGCCAATCAG AAAATCCAGG AACTCCAGGC CAGCCAAGAA 900 GCAAGAGCAG ACCACGAGCA GCAGATTAAG GATCTGGAGC AGAAGCTGTC CCTGCAAGAG 960 CAGGATGCAG CGATTGTGAA GAACATGAAG TCTGAGCTGG TACGGCTCCC TAGGCTGGAA 1020 CGGGAGCTGA AGCAGCTGCG GGAGGAGAGC GCGCACCTGC GGGAGATGAG AGAGACCAAC 1080 GGGCTGCTCC AGGAAGAGCT GGAAGGGCTG CAGAGGAAGC TGGGGCGCCA GGAGAAGATG 1140 CAGGAGACGC TGGTTGGCTT GGAGCTGGAG AACGAGAGGC TGCTGGCCAA GCTGCAAAGC 1200 TGGGAGAGAC TGGACCAGAC CATGGGCCTG AGCATCAGGA CTCCAGAAGA CCTTTCCAGA 1260 TTCGTGGTTG AGCTGCAGCA GAGGGAGCTT GCCTTGAAGG ACAAGAACAG CGCCGTCACC 1320 AGCAGCGCCC GGGGGCTGGA GAAGGCCAGG CAGCAGCTGC AGGAGGAGCT CCGGCAGGTC 1380 AGCGGCCAGC TGTTGGAGGA GAGGAAGAAG CGCGAGACCC ACGAGGCGCT GGCCCGGAGG 1440 CTCCAGAAAC GGGTCCTGCT GCTCACCAAG GAGCGGGACG GTATGCGGGC CATCCTGGGG 1500 TCCTACGACA GCGAGCTGAC CCCGGCCGAG TACTCACCCC AGCTGACGCG GCGCATGCGG 1560 GAGGCTGAGG ATATGGTGCA GAAGGTGCAC AGCCACAGCG CCGAGATGGA GGCTCAGCTG 1620 TCGCAGGCCC TGGAGGAGCT GGGAGGCCAG AAACAAAGAG CAGACATGCT GGAGATGGAG 1680 CTGAAGATGC TGAAGTCTCA GTCCAGCTCT GCCGAACAGA GCTTCCTGTT CTCCAGGGAG 1740 GAGGCGGACA CGCTCAGGTT GAAGGTCGAG GAGCTGGAAG GCGAGCGGAG TCGGCTGGAG 1800 GAGGAAAAGA GGATGCTGGA GGCACAGCTG GAGCGGCGAG CTCTGCAGGG TGACTATGAC 1860 CAGAGCAGGA CCAAAGTGCT GCACATGAGC CTGAACCCCA CCAGTGTGGC CAGGCAGCGC 1920 CTGCGCGAGG ACCACAGCCA GCTGCAGGCG GAGTGCGAGC GACTGCGCGG GCTCCTGCGC 1980 GCCATGGAGA GAGGAGGCAC CGTCCCAGCC GACCTTGAGG CTGCCGCCGC GAGTCTGCCA 2040 TCGTCCAAGG AGGTGGCAGA GCTGAAGAAG CAGGTGGAGA GTGCCGAGCT GAAGAACCAG 2100 CGGCTCAAGG AGGTTTTCCA GACCAAGATC CAGGAGTTCC GCAAGGCCTG CTACACGCTC 2160 ACCGGCTACC AGATCGACAT CACCACGGAG AACCAGTACC GGCTGACCTC GCTGTACGCC 2220 GAGCACCCAG GCGACTGCCT CATCTTCAAG GCCACCAGCC CCTCGGGTTC CAAGATGCAG 2280 CTACTGGAGA CAGAGTTCTC ACACACCGTG GGCGAGCTCA TCGAGGTGCA CCTGCGGCGC 2340 CAGGACAGCA TCCCTGCCTT CCTCAGCTCG CTCACCCTCG AGCTCTTCAG CCGCCAGACC 2400

GTGGCGTAGC CTGCAGGCTC GGGGGCATAG CCGGAGCCAC TCTGCTTGGC CTGACCTGCA 2460 GGTCCCCTGC CCCGCCAGCC ACAGGCTGGG TGCACGTCCT GCCTCTCCAG CCCCACAGGG 2520 CAGCAGCATG ACTGACAGAC ACGCTGGGAC CTACGTCGGG CTTCCTGCTG GGGCGGCCAG 2580 CACCCTCTCC ACGTGCAGAC CCCATGCGTC CCGGAGCCTG GTGTGTGGGC GTCGGCCACC 2640 AGCCTGGGTT CCTCACCTTG TGAAATAAAA TCTTCTCCCC TAG 2683 Seq ID NO : 180 DNA Sequence Nucleic Acid Accession # : NM 000273. 1 Coding sequence : 1.. 1275 1 11 21 31 41 51 ATGACCCAGG CAGGCCGGCG GGGTCCTGGC ACACCCGAGC CGCGTCCGCG AACACAGCCC 60 ATGGCCTCCC CGCGCCTAGG GACCTTCTGC TGCCCCACGC GGGACGCAGC CACGCAGCTC 120 GTGCTGAGCT TCCAGCCGCG GGCCTTCCAC GCGCTCTGCC TGGGCAGCGG CGGGCTCCGC 180 TTGGCGCTGG GCCTTCTGCA GCTGCTGCCC GGCCGCCGGC CCGCGGGCCC CGGGTCCCCC 240 GCGACGTCCC CGCCGGCCTC GGTCCGCATC CTGCGCGCTG CCGCTGCCTG CGACCTTCTC 300 GGCTGCCTGG GTATGGTGAT CCGGTCCACC GTGTGGTTAG GATTCCCAAA TTTTGTTGAC 360 AGCGTCTCGG ATATGAACCA CACGGAAATT TGGCCTGCTG CTTTCTGCGT GGGGAGTGCG 420 ATGTGGATCC AGCTGTTGTA CAGTGCCTGC TTCTGGTGGC TGTTTTGCTA TGCAGTGGAT 480 GCTTATCTGG TGATCCGGAG ATCGGCAGGA CTGAGCACCA TCCTGCTGTA TCACATCATG 540 GCGTGGGGCC TGGCCACCCT GCTCTGTGTG GAGGGAGCCG CCATGCTCTA CTACCCTTCC 600 GTGTCCAGGT GTGAGCGGGG CCTGGACCAC GCCATCCCCC ACTATGTCAC CATGTACCTG 660 CCCCTGCTGC TGGTTCTCGT GGCGAACCCC ATCCTGTTCC AAAAGACAGT GACTGCAGTG 720 GCCTCTTTAC TTAAAGGAAG ACAAGGCATT TACACGGAGA ACGAGAGGAG GATGGGAGCC 780 GTGATCAAGA TCCGATTTTT CAAAATCATG CTGGTTTTAA TTATTTGTTG GTTGTCGAAT 840 ATCATCAATG AAAGCCTTTT ATTCTATCTT GAGATGCAAA CAGATATCAA TGGAGGTTCT 900 TTGAAACCTG TCAGAACTGC AGCCAAGACC ACATGGTTTA TTATGGGAAT CCTGAATCCA 960 GCCCAGGGAT TTCTCTTGTC TTTGGCCTTC TACGGCTGGA CAGGATGCAG CCTGGGTTTT 1020 CAGTCTCCCA GGAAGGAGAT CCAGTGGGAA TCACTGACCA CCTCGGCTGC TGAGGGGGCT 1080 CACCCATCCC CACTGATGCC CCATGAAAAC CCTGCTTCCG GGAAGGTGTC TCAAGTGGGT 1140 GGGCAGACTT CTGACGAAGC CCTGAGCATG CTGTCTGAAG GTTCTGATGC CAGCACAATT 1200 GAAATTCACA CTGCAAGTGA ATCCTGCAAC AAAAATGAGG GTGACCCTGC TCTCCCAACC 1260 CATGGAGACC TATGAAGGGG ATGTGCTGGG GGTCCAGACC CCATATTCCT CAGACTCAAC 1320 AATTCTTGTT CTTTAGAACT GTGTTCTCAC CTTCCCAACA CTGCACTGCC GAAGTGTAGC 1380 GGCCCCCAAA CCTTGCTCTC ATCACCAGCT AGAGCTTCTT CCCGAAGGGC CTTTAGGATA 1440 GGAGAAAGGG TTCATGCACA CACGTGTGAG AATGGAAGAG CCCCCTCCAG ACCACTCTAC 1500 AGCTGCTCTA GCCTTAGTTG CCACTAGGAA GTTTTCTGAG GCTGGCTGTA AAGTAAGTGT 1560 AAGGTCCACA TCCTTGGGGA AGTAGTTAAA TAAAATAGTT ATGACTG 1607 Seq ID NO : 181 DNA Sequence Nucleic Acid Accession # : Nom 139317. 1 Coding sequence : 174.. 1070 1 11 21 31 41 51 1-1 1 1 1 CCCTGGGATA CTCCCCTCCC AGGGTGTCTG GTGGCAGGCC TGTGCCTATC CCTGCTGTCC 60 CCAGGGTGGG CCCCGGGGGT CAGGAGCTCC AGAAGGGCCA GCTGGGCATA TTCTGAGATT 120 GGCCATCAGC CCCCATTTCT GCTGCAAACC TGGTCAGAGC CAGTGTTCCC TCCATGGGAC 180 CTAAAGACAG TGCCAAGTGC CTGCACCGTG GACCACAGCC GAGCCACTGG GCAGCCGGTG 240 ATGGTCCCAC GCAGGAGCGC TGTGGACCCC GCTCTCTGGG CAGCCCTGTC CTAGGCCTGG 300 ACACCTGCAG AGCCTGGGAC CACGTGGATG GGCAGATCCT GGGCCAGCTG CGGCCCCTGA 360 CAGAGGAGGA AGAGGAGGAG GGCGCCGGGG CCACCTTGTC CAGGGGGCCT GCCTTCCCCG 420 GCATGGGCTC TGAGGAGTTG CGTCTGGCCT CCTTCTATGA CTGGCCGCTG ACTGCTGAGG 480 TGCCACCCGA GCTGCTGGCT GCTGCCGGCT TCTTCCACAC AGGCCATCAG GACAAGGTGA 540 GGTGCTTCTT CTGCTATGGG GGCCTGCAGA GCTGGAAGCG CGGGGACGAC CCCTGGACGG 600 AGCATGCCAA GTGGTTCCCC AGCTGTCAGT TCCTGCTCCG GTCAAAAGGA AGAGACTTTG 660 TCCACAGTGT GCAGGAGACT CACTCCCAGC TGCTGGGCTC CTGGGACCCG TGGGAAGAAC 720 CGGAAGACGC AGCCCCTGTG GCCCCCTCCG TCCCTGCCTC TGGGTACCCT GAGCTGCCCA 780 CACCCAGGAG AGAGGTCCAG TCTGAAAGTG CCCAGGAGCC AGGAGGGGTC AGTCCAGCCG 840 AGGCCCAGAG GGCGTGGTGG GTTCTTGAGC CCCCAGGAGC CAGGGATGTG GAGGCGCAGC 900 TGCGGCGGCT GCAGGAGGAG AGGACGTGCA AGGTGTGCCT GGACCGCGCC GTGTCCATCG 960 TCTTTGTGCC GTGCGGCCAC CTGGTCTGTG CTGAGTGTGC CCCCGGCCTG CAGCTGTGCC 1020 CCATCTGCAG AGCCCCCGTC CGCAGCCGCG TGCGCACCTT CCTGTCCTAG GCCAGGTGCC 1080 ATGGCCGGCC AGGTGGGCTG CAGAGTGGGC TCCCTGCCCC TCTCTGCCTG TTCTGGACTG 1140 TGTTCTGGGC CTGCTGAGGA TGGCAGAGCT GGTGTCCATC CAGCACTGAC CAGCCCTGAT 1200 TCCCCGACCA CCGCCCAGGG TGGAGAAGGA GGCCCTTGCT TGGCGTGGGG GATGGCTTAA 1260 CTGTACCTGT TTGGATGCTT CTGAATAGAA ATAAAGTGGG TTTTCCCTGG AGGTACCCAG 1320 CA 1322 Seq ID NO : 182 DNA Sequence Nucleic Acid Accession # : Nom 022161. 2 Coding sequence : 174.. 1016 1 11 21 31 41 51 CCCTGGGATA CTCCCCTCCC AGGGTGTCTG GTGGCAGGCC TGTGCCTATC CCTGCTGTCC 60 CCAGGGTGGG CCCCGGGGGT CAGGAGCTCC AGAAGGGCCA GCTGGGCATA TTCTGAGATT 120 GGCCATCAGC CCCCATTTCT GCTGCAAACC TGGTCAGAGC CAGTGTTCCC TCCATGGGAC 180 CTAAAGACAG TGCCAAGTGC CTGCACCGTG GACCACAGCC GAGCCACTGG GCAGCCGGTG 240 ATGGTCCCAC GCAGGAGCGC TGTGGACCCC GCTCTCTGGG CAGCCCTGTC CTAGGCCTGG 300 ACACCTGCAG AGCCTGGGAC CACGTGGATG GGCAGATCCT GGGCCAGCTG CGGCCCCTGA 360 CAGAGGAGGA AGAGGAGGAG GGCGCCGGGG CCACCTTGTC CAGGGGGCCT GCCTTCCCCG 420 GCATGGGCTC TGAGGAGTTG CGTCTGGCCT CCTTCTATGA CTGGCCGCTG ACTGCTGAGG 480 TGCCACCCGA GCTGCTGGCT GCTGCCGGCT TCTTCCACAC AGGCCATCAG GACAAGGTGA 540 GGTGCTTCTT CTGCTATGGG GGCCTGCAGA GCTGGAAGCG CGGGGACGAC CCCTGGACGG 600 AGCATGCCAA GTGGTTCCCC AGCTGTCAGT TCCTGCTCCG GTCAAAAGGA AGAGACTTTG 660

TCCACAGTGT GCAGGAGACT CACTCCCAGC TGCTGGGCTC CTGGGACCCG TGGGAAGAAC 720 CGGAAGACGC AGCCCCTGTG GCCCCCTCCG TCCCTGCCTC TGGGTACCCT GAGCTGCCCA 780 CACCCAGGAG AGAGGTCCAG TCTGAAAGTG CCCAGGAGCC AGGAGCCAGG GATGTGGAGG 840 CGCAGCTGCG GCGGCTGCAG GAGGAGAGGA CGTGCAAGGT GTGCCTGGAC CGCGCCGTGT 900 CCATCGTCTT TGTGCCGTGC GGCCACCTGG TCTGTGCTGA GTGTGCCCCC GGCCTGCAGC 960 TGTGCCCCAT CTGCAGAGCC CCCGTCCGCA GCCGCGTGCG CACCTTCCTG TCCTAGGCCA 1020 GGTGCCATGG CCGGCCAGGT GGGCTGCAGA GTGGGCTCCC TGCCCCTCTC TGCCTGTTCT 1080 GGACTGTGTT CTGGGCCTGC TGAGGATGGC AGAGCTGGTG TCCATCCAGC ACTGACCAGC 1140 CCTGATTCCC CGACCACCGC CCAGGGTGGA GAAGGAGGCC CTTGCTTGGC GTGGGGGATG 1200 GCTTAACTGT ACCTGTTTGG ATGCTTCTGA ATAGAAATAA AGTGGGTTTT CCCTGGAGGT 1260 ACCCAGCA 1268 Seq ID NO : 183 DNA Sequence Nucleic Acid Accession # : Nom 021020. 1 Coding sequence : 112.. 1902 1 11 21 31 41 51 1 1 1 1 1 1 TGAGGGCTTT GCTATGACCT CAGTCCCCTC ACGGAGCCAC GACTGCCCCT TGCTGCCACA 60 GCCTTTCCAA GACCCTGCCC GGCCCTGCCC CATCCTCAGC CCCGAGTCAC CATGGGCAGC 120 GTCAGTAGCC TCATCTCCGG CCACAGCTTC CACAGCAAGC ACTGCCGGGC TTCGCAGTAC 180 AAGCTGCGCA AGTCCTCCCA CCTCAAGAAG CTCAACCGGT ATTCCGACGG GCTGCTGAGG 240 TTTGGCTTCT CCCAGGACTC CGGTCACGGC AAGTCCAGCT CCAAAATGGG CAAGAGCGAA 300 GACTTCTTCT ACATCAAGGT CAGCCAGAAA GCCCGGGGCT CCCATCACCC AGATTACACG 360 GCACTGTCCA GCGGGGATTT AGGGGGCCAG GCTGGGGTGG ACTTTGACCC GTCCACACCC 420 CCCAAGCTCA TGCCCTTCTC CAATCAGCTA GAAATGGGCT CCGAGAAGGG TGCAGTGAGG 480 CCCACAGCCT TCAAGCCTGT GCTGCCACGG TCAGGAGCCA TCCTGCACTC CTCCCCGGAG 540 AGTGCCAGCC ACCAGCTGCA CCCCGCCCCT CCAGACAAGC CCAAGGAGCA GGAGCTGAAG 600 CCTGGCCTGT GCTCTGGGGC GCTGTCAGAC TCCGGCCGGA ACTCCATGTC CAGCCTGCCC 660 ACACACAGCA CCAGCAGCAG CTACCAGCTG GACCCGCTGG TCACACCCGT GGGACCCACA 720 AGCCGTTTTG GGGGCTCCGC CCACAACATC ACCCAGGGCA TCGTCCTCCA GGACAGCAAC 780 ATGATGAGCC TGAAGGCTCT GTCCTTCTCC GACGGAGGTA GCAAGCTGGG CCACTCGAAC 840 AAGGCAGACA AGGGCCCCTC GTGTGTCCGC TCCCCCATCT CCACGGACGA GTGCAGCATC 900 CAGGAGCTGG AGCAGAAGCT GTTGGAGAGG GAGGGCGCCC TCCAGAAGCT GCAGCGCAGC 960 TTTGAGGAGA AGGAGCTTGC CTCCAGCCTG GCCTACGAGG AGCGGCCGCG GCGCTGCAGG 1020 GACGAGCTGG AGGGCCCGGA GCCCAAAGGC GGCAACAAGC TCAAGCAGGC CTCGCAGAAG 1080 AGCCAGCGCG CGCAGCAGGT CCTGCACCTG CAGGTACTGC AGCTTCAGCA GGAGAAGCGG 1140 CAGCTCCGGC AGGAGCTCGA GAGCCTCATG AAGGAGCAGG ACCTGCTGGA GACCAAGCTC 1200 AGGTCCTACG AGAGGGAGAA GACCAGCTTC GGCCCCGCGC TGGAGGAGAC CCAGTGGGAG 1260 GTGTGCCAGA AGTCAGGCGA GATCTCCCTC CTGAAGCAGC AGCTGAAGGA GTCCCAGACG 1320 GAGGTGAACG CCAAGGCTAG CGAGATCCTG GGTCTCAAGG CACAGCTGAA GGACACGCGG 1380 GGCAAGCTGG AGGGCCTGGA GCTGAGGACC CAGGACCTGG AGGGCGCCCT GCGCACCAAG 1440 GGCCTGGAGC TGGAGGTCTG TGAGAATGAG CTGCAGCGCA AGAAGAACGA GGCGGAGCTG 1500 CTGCGGGAGA AGGTGAACCT GCTGGAGCAG GAGCTGCAGG AGCTGCGGGC CCAGGCCGCC 1560 CTGGCCCGCG ACATGGGGCC GCCCACCTTC CCCGAGGACG TCCCTGCCCT GCAGCGGGAG 1620 CTGGAGCGGC TGCGGGCCGA GCTGCGGGAG GAGCGGCAAG GCCATGACCA GATGTCCTCG 1680 GGCTTCCAGC ATGAGCGGCT CGTGTGGAAG GAGGAGAAGG AGAAGGTGAT TCAGTACCAG 1740 AAACAGCTGC AGCAGAGCTA CGTGGCCATG TACCAGCGGA ACCAGCGCCT GGAGAAGGCC 1800 CTGCAGCAGC TGGCACGTGG GGACAGCGCC GGGGAGCCCT TGGAGGTTGA CCTGGAAGGG 1860 GCTGACATCC CCTACGAGGA CATCATAGCC ACTGAGATCT GAGGGGCTGC CTGGGAAGGC 1920 GAGTCTGGGG ACCTGGCACT GGGAGGCAGG GCTCTCCCGT GCATCCCCCC TGCTCAGCAA 1980 TTCAGACCCC TCTGAGAGAC GCCACTCCCT GGGACACAGA CCCAGGACCC CCGAGGGGAG 2040 GGCAGGATGG CCTTTCCTTC CCTCTCTGAT GTCCCAGTGC TCACCAGCCC TGCAGCCCAC 2100 CAGACGTCAG GCCCTGACTC CTCTGGCTTT CCCAGGAGAT GGGTCCAGGG GTCTGTCTGC 2160 TTTGGTTAAG GGCTCCCTAA ACTTTGGCCT TTGTTCGAAA TAGATATCCT CTCCCCCTCC 2220 TCCAGGGAAG GTGGCCACAG CAAGAACAGC GGCTCCCCTC CGCTTCTCAT CCCAACCTCT 2280 TTTTCCTCCT GGACACATTG GAATGCCTTG GAAATAGAAA GAAGCCATAT ATGACCAGAA 2340 GCCTTGGAAC CAGCCCCATC AGAACCTGAG CTATTTTCCT CTGGCCGCAG AGGTGTAGGG 2400 GTGGAATGAG CCGCGGGGAA GCTGGCTTTG AAACCTCAGG GCTGTCCCAG CCCCGGCAAG 2460 CCACAGGAAG GAGGGGAGAG ACAGGCAGCC CAGCAGTGTG GAGACCCTGC CACAGCCAGA 2520 GGAGGGCAGA GGGAGAATCC AAGGGTTGAG AGCCAGTGGC GGGTGATGGC CAGCCCCTGG 2580 GGCCCAGCCC CTGTTTACTG GTTCTTGCAA ATGGGAGCTG AGCAGCCTCT GGACAGCCAG 2640 TGACCTTTGA CCTCGGTGAC CACTCTTCTT TAAGCCATAG ACCCTGAGGC CCTGGGCTGG 2700 GTGCTGGGAA GGGAGGGTTG AAACCACCGT GAACCAGAGG GTGTGGCTTT CCAGGCACCC 2760 TCAGGGAGCC TCCCCATCTG TCCAGCTGGG GCCAGAGGCT GGGAGTCCCT ACCTGCTTCA 2820 CGTTGGCCGG CGGCTACTCT GGAATGTTTT TCCCTCCCCA GAATCAAGCT TTTGCTTGAT 2880 CCAGAAGAGC CCATATCACT AAGATGGCAT ATATGTGATC TGGGCATTTT CCTCCTCTGC 2940 CTACAGCCAG GTTTAGCGGC AAACCTTTCC CCCTTAGCAC CTTCAGGGCT GAGTTCTGGG 3000 TTTCTAGAGG TCAGGACGGC TCCTCAGAGC GCCAGGAAGC CAGAGCCCCA AGCAGGACGA 3060 AAAAGAGGCA TACACACAGC AGTGTGAATA GCCTGGCCAC CAGCCATCCT CCCTCCACCT 3120 CAAGACCCCC ATTTGTCCCA GACTAAAGGA TCCAGAGAGC AGCTCCCTTT CTCAGGAGCT 3180 TGGGCAGTGC CCCAGGGAGT CCAGGGTTTC TCTGCAGATG TGCGGAGCGG GAGGCGGTGG 3240 TAGAGAGAGA TAAAAGGTGG AGTTTCTCTG TTGTTTGGTT CAGGGATTTT ATTTTTAATT 3300 TTATGAGACA GGGTCTTGCT CTGTCCCCCA GGCTGGAGTG CAGTGGCATG ATCATAGCTC 3360 ACTGCAGCCT CATACTCCTG GGCTCAAGCA ATCCTCCTGC CTCAGCCTTC CAACTAGCTG 3420 GGACTACAGG TGCGCGCCAC CGTGCCTGGC TAACTTTTCA TTTTTTTTGT AGGGACGGGG 3480 TCTCGTTTTG TTGCCAAAGC TGGTCTCAAA CTTGTGGCCT CAAGCAATCC ACCTGCCTTG 3540 GCCTCCCAAA GTGCTGAGAT TGCAGATGTG AGCCACCGTG CCTGGCCAGA TTTTTCTTTT 3600 ATTCTTCTTT CTTTTTCTTT TTTGCTTTCT TGTCTTTTCA GAAGCAAGCC AGACCTAGCA 3660 GGCTGTTCCA TGTTCTATTT TTGACTGTAG CCACAGCTGC TGTTCTCAGG ACAGCATCCC 3720 TTCCCACATG CCTGCGCCTG CTGCCTGCTG AGATGAGGAG GGGAGCGTCT GGGAACTTGC 3780 GAGTCCAAGG CCAGTCCCCA TTTCTGCCTC GCTCACCGCT GGCCCTTAGA GACCCCGAGG 3840 TAGGGGTGGG GAGATGCTTC TCTCCTTGCC CCCCGCCCTC ATGGGTCCTA GCCCTTCCCT 3900 GAGTGCGGGC TGAGGCCAGA GTCACCTTTT CTGTGGCTGG CTCTACCTTC CTGTCCCTGA 3960 GGTTAAACGG TGCCCATCCT GCCATCCTCA AACGACAGAG GAGCTTTTCT GGAATTTCAA 4020

ACCATTGCTC TTAGTCCCAA GCTAGGCTTA AACCTGGAAT CTACAAGCCA AAAGTCCCTC 4080 CCTGCCTGAG GGCAGTACCC TCCATTGGGC ACAGTCCAGA CCCAAGTCAA AGATGCCCCA 4140 TTCCTTGCGC CTCAGCCCTC AGTTCCTTCA TTTCCACCAG GCCGTGCCTT GTTTGAGTTT 4200 TTCCTCCCAG TGAGACTGCC CCACGGAGAC AGAGGAAAGG GCTGGCTCCC CCTCCCCAGG 4260 CTGGAGACCC CCCCCAACTC CAGGAAAGAG CAGTCAGAGT CCAGTGCTCT GCCTCAGACG 4320 TTGCCTGAGA AGAAGTGGCT GCCACACCCA GGGGAAGGCC CTGAGGCGGA GGCTGTGCTC 4380 CGCCATGGTG TCCCGGTACC TTCCATACAC AGAGGAGTGC AGCCTTCTCC ATATCTCCAT 4440 GGCCCTGTCC CAGGCCGGCC CAGATGTGTC CCCCCCAGGC CTTGTCCTAC GTCCAAGGTG 4500 GCAGATGTCT TCCCTGGGCT GCCACCAGCC CCCGCCCCAG AGTGGCCCAC CGTGGCACTA 4560 GAATGCAAGT ATCCTGCGAC CTTGCAACCT CACCTTCCTG TGGGTGTTCT TTCCTGCCCT 4620 GTCCAAAAGC GCCCTCACTA TTCTTGGACC ATGCCAGATT CTGCCTCTCT GGAAAGAGGC 4680 TCTGGACAGC AGAAGCCTCC AAGCACAGAG CCTGGCCCCA GGCCCCAGAC AGGGTGGGCT 4740 TCCTGCCCTT CCCTCTGGGC ACGCCTGCTG GCCGACCCAC TGACCCACTC GGATGGACCA 4800 ACCTGCTCTG TCCCCAAAGG ACGCCTGCAG GAGAGAGCAG CACTCCGCAT CACCTCACCA 4860 AGGATCGGAC TCTGCCCCTG GACCTGGGAA CGACTGGACT GTCACGGGGT TCCCTCCTAG 4920 CTCTCCCAGT GAACTCCTGC CAGGCACACA CAGCCCCTAT AGCACTGAGC TCACATGGGA 4980 CTGGGATATG GGGGCATCTC TTCCCCAGAG AGGCACTCAG TGAGCCTCCT GTGCCTGGCC 5040 CCAGTCTGGG CCATCTCTTA GGTGAGACAG TTGCCCGAAA CTAAGCCAGG CCTGGCTGGA 5100 GGAGCAGCAG CTTGGGGAGA GGGATTTCCC TGCAGACCTC AAGCCATCAT GCGGTGGGTG 5160 CTGCCATGAC AGAGGCTGCA CCCCTGGGCC AGCGGGGCTG CTCACCCACC TCTTGTGCAA 5220 GGTGGCCTTT GTGCTGCGCC TGCAGGCAGA GCTGGAGCCC CCAGCAGAGG CAGGCTGGGA 5280 CGGACCAGCA TCTGGAAGAT GTACATAGTT ATTTTTCTCT TTGTGGTTTC TTGTTTGGTT 5340 TGGTTTGCTT TTGACAGCTT CATTTTATTT TTGACGTCAC TTTTTGGCCA TGTAAACTAT 5400 TTGTGGCAAT TTTATGTTTT TATTTATGAA TAAAGAATGC CATTTCTCAC GCCCTCTAAA 5460 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AA 5492 Seq ID NO : 184 DNA Sequence Nucleic Acid Accession # : AF265577 Coding sequence : 1.. 2193 1 11 21 31 41 51 ATGCCCAAAA ATAGCAAGGT GGTAAAAAGA GAATTAGATG ATGATGTTAC TGAGTCTGTC 60 AAAGACCTTC TTTCCAATGA AGACGCAGCT GATGATGCTT TTAAGACAAG TGAACTAATT 120 GTTGATGGCC AGGAAGAGAA AGATACAGAT GTTGAAGAAG GATCTGAAGT CGAAGATGAA 180 AGACCAGCTT GGAACAGTAA ACTACAATAC ATCCTGGCCC AAGTTGGATT TTCTGTAGGT 240 TTAGGAAATG TGTGGCGATT TCCATACCTA TGTCAGAAGA ATGGGGGCGG TGCATATCTT 300 TTACCATATT TAATACTACT TATGGTAATA GGTATTCCCC TTTTTTTCTT GGAACTCTCT 360 GTGGGTCAAA GAATTCGGCG AGGCAGCATT GGTGTATGGA ATTACATAAG CCCTAAACTG 420 GGCGGGATTG GATTTGCAAG TTGTGTAGTG TGCTATTTTG TAGCTCTCTA CTACAACGTC 480 ATCATTGGCT GGAGTTTGTT TTATTTTTCT CAGTCTTTTC AGCAACCCCT GCCTTGGGAT 540 CAGTGTCCTT TGGTGAAAAA TGCTTCACAC ACTTTTGTAG AACCAGAATG TGAACAAAGT 600 TCTGCCACCA CCTATTACTG GTACAGGGAA GCACTGAATA TTTCAAGTTC CATTTCTGAA 660 AGTGGGGGCT TAAACTGGAA GATGACCATC TGCTTGTTGG CTGCCTGGGT CATGGTTTGC 720 TTGGCTATGA TCAAAGGCAT TCAGTCTTCT GGAAAAATCA TATATTTTAG TTCTCTGTTT 780 CCATATGTGG TACTTATTTG CTTCCTCATC AGAGCATTCC TTTTAAATGG TTCAATTGAT 840 GGCATTCGCC ACATGTTTAC CCCTAAGCTT GAAATAATGC TGGAGCCCAA GGTCTGGAGA 900 GAAGCTGCTA CTCAAGTGTT CTTTGCCTTA GGTCTGGGAT TTGGTGGTGT CATTGCCTTT 960 TCAAGCTACA ACAAGAGAGA CAACAACTGC CACTTTGATG CTGTCCTGGT GTCCTTCATC 1020 AATTTTTTCA CTTCTGTCCT GGCAACATTG GTGGTGTTTG CAGTTCTGGG CTTCAAAGCA 1080 AATGTCATAA ATGAGAAATG CATTACACAA AATTCAGAGA CGATCATGAA ATTTTTGAAA 1140 ATGGGGAACA TTAGTCAGGA TATTATTCCC CATCATATCA ACCTTTCAAC TGTTACTGCA 1200 GAAGATTATC ATTTAGTTTA TGACATCATT CAAAAAGTGA AAGAAGAAGA GTTTCCTGCT 1260 CTTCATCTCA ATTCCTGTAA AATTGAAGAA GAGCTAAATA AAGCTGTTCA GGGGACCGGC 1320 TTAGCTTTTA TTGCCTTTAC AGAAGCGATG ACACATTTTC CTGCATCTCC CTTCTGGTCA 1380 GTGATGTTTT TCCTCATGCT GGTCAATCTA GGCCTTGGCA GTATGTTTGG AACCATTGAA 1440 GGGATTGTCA CGCCTATTGT GGACACTTTC AAAGTGAGGA AAGAAATTCT TACTGTTATC 1500 TGTTGTCTTC TGGCATTTTG TATTGGCCTG ATATTTGTGC AACGCTCTGG AAATTACTTT 1560 GTTACAATGT TTGATGATTA TTCTGCTACA CTGCCTCTGC TAATTGTAGT CATTTTGGAG 1620 AATATTGCTG TATGCTTTGT TTATGGCATA GATAAGTTTA TGGAAGACCT AAAAGATATG 1680 CTGGGCTTTG CTCCCAGCAG ATATTACTAC TATATGTGGA AATATATTTC TCCTCTAATG 1740 CTATTATCAT TGCTAATAGC TAGTGTTGTG AATATGGGAT TAAGTCCTCC TGGCTATAAC 1800 GCATGGATTG AAGATAAGGC ATCTGAAGAA TTTCTGAGCT ATCCAACATG GGGACTGGTT 1860 GTTTGTGTCT CTCTGGTTGT CTTTGCAATA CTCCCAGTCC CTGTAGTTTT CATTGTTCGT 1920 CGCTTCAACC TTATAGATGA TAGTTCTGGT AATTTAGCAT CTGTGACCTA TAAGAGAGGA 1980 AGGGTCCTGA AAGAGCCTGT GAACTTAGAG GGCGATGATA CAAGCCTCAT TCACGGAAAA 2040 ATACCGAGCG AGATGCCATC TCCAAATTTT GGTAAAAATA TTTATCGAAA ACAGAGTGGA 2100 TCCCCAACTC TGGATACTGC TCCCAATGGA CGGTATGGAA TAGGGTACTT GATGGCAGAT 2160 ATTATGCCAG ATATGCCAGA ATCTGATTTG TAG 2193 Seq ID NO : 185 DNA Sequence Nucleic Acid Accession # : NM_031945. 1 Coding sequence : 65.. 1132 1 11 21 31 41 51 1 1 1 1 1 1 CACAGAGGAG CCAGCGAACC TCTCCCGGCG CCTGTTCTGG GGGCTTTCTG TTCCAGCGTC 60 AAGGATGGAG GAGGGGGAGA GGAGCCCCTT ACTGTCCCAG GAAACTGCAG GCCAGAAGCC 120 CCTCTCTGTG CACAGGCCAC CCACCTCAGG CTGCCTAGGT CCAGTGCCCA GGGAGGACCA 180 GGCGGAGGCC TGGGGCTGCA GCTGCTGTCC CCCGGAGACC AAGCACCAGG CCTTGAGTGG 240 CACTCCCAAG AAAGGACCAG CCCCTTCCCT CTCCCCAGGG AGCAGCTGCG TCAAGTATCT 300 GATCTTCCTC TCCAACTTCC CCTTCTCCCT GCTGGGGCTG CTGGCCCTGG CCATCGGGCT 360 CTGGGGCCTG GCTGTCAAGG GGTCTCTGGG AAGTGATCTG GGGGGGCCCC TGCCCACAGA 420 CCCCATGCTG GGGCTGGCAC TGGGAGGGCT GGTGGTCAGC GCAGCGAGCC TGGCTGGCTG 480 CCTGGGCGCC CTCTGCGAGA ACACCTGCCT GTTACGTGGC TTCTCCGGGG GCATCCTTGC 540 CTTCCTGGTG CTTGAGGCCG TGGCGGGGGC CCTGGTGGTG GCCCTCTGGG GCCCGCTGCA 600

AGACAGCCTG GAGCACACCC TGCGTGTGGC CATCGCCCAC TACCAGGACG ACCCAGACCT 660 GCGCTTCCTC CTCGACCAAG TCCAGCTCGG GCTGAGGTGC TGCGGAGCTG CCTCCTACCA 720 GGACTGGCAG CAGAACCTGT ACTTTAACTG CAGCTCCCCC GGGGTGCAGG CCTGCAGCCT 780 TCCCGCCTCC TGCTGCATCG ACCCCCGCGA AGATGGAGCC TCTGTCAACG ACCAGTGCGG 840 CTTCGGGGTC CTGCGCCTGG ATGCGGACGC AGCTCAGAGA GTGGTGTACC TGGAGGGCTG 900 CGGCCCGCCG CTCCGGCGGT GGCTGCGCGC GAACCTGGCT GCCTCGGGCG GCTACGCAAT 960 CGCGGTGGTG CTGCTGCAGG GGGCGGAGCT CCTGCTGGCC GCCCGGCTAC TCGGGGCCCT 1020 CGCTGCCCGC AGTGGGGCGG CGTACGGCCC CGGAGCGCAC GGGGAGGACC GCGCTGGCCC 1080 CCAGAGCCCC AGCCCCGGCG CCCCGCCCGC TGCCAAACCC GCCCGGGGCT GAGCGCACGC 1140 CCCGAGGTCC GAGACCGCCA CGCACAGGGA TACAGGGGGC GCCTCCGCCC GGCTAAAAAG 1200 CGCTGCCTGC GCCGCCGCCG CCGCCTGATT TCGCTCGGGC TTCGGGTGAC TTCGCCGCAG 1260 GACCTACCCA GCTCGCTCAC TTCGCTCGCT CCGCGTCCCC CATGCCAGCC CCCAACGCAG 1320 GGCGCCCGGC GAAGCCACGG GACTGGCGGG AGGAGCACGC GGGGCCGGAG GAAATCCTGG 1380 AGCTGACCCT CACCTCCGAG CCCCCACTCC CACCCCAGCC GCACAGTTCC CACCTCCTGG 1440 CACCTCCCTC CCCTGGGGCC GCCACCCCTT CTGGGCTCGT GATGGTGGAG CTAAGGTCCA 1500 GGCCTCTCCC TCCCGAGTGC ATTTTTGGGG AGATAGTAAA TGTTTTATTC GGGTGTATCA 1560 TTCATACAGT AAAGACACCA ATCTTCAAAA AAAAAAAAAA A 1601 Seq ID NO : 186 DNA Sequence Nucleic Acid Accession # : AF475085. 1 Coding sequence : 54.. 1715 1 11 21 31 41 51 GCGCCCTCGC CGCGGACACC GGAGCTGCGG CCGCTCCCCG CTGTCCCCCA GAGATGGCAG 60 ATCCTGAGGT AGTTGTGAGT AGCTGCAGCT CTCATGAAGA GGAAAATCGC TGCAATTTTA 120 ACCAGCAAAC ATCTCCATCT GAGGAGCTTC TATTAGAAGA CCAGATGAGG CGAAAACTCA 180 AATTTTTTTT CATGAATCCC TGTGAGAAGT TCTGGGCTCG AGGTAGAAAA CCATGGAAAC 240 TTGCCATACA AATTCTAAAA ATTGCAATGG TGACTATCCA GCTGGTCTTA TTTGGGCTAA 300 GTAACCAGAT GGTGGTAGCT TTCAAGGAAG AGAATACTAT AGCATTCAAA CACCTTTTCC 360 TAAAAGGATA TATGGACCGA ATGGATGACA CATATGCAGT GTACACACAA AGTGACGTGT 420 ATGATCAGTT AATCTTCGCA GTAAACCAGT ACTTGCAGCT ATACAATGTC TCCGTTGGGA 480 ATCATGCTTA TGAGAACAAA GGTACCAAGC AATCTGCTAT GGCAATCTGT CAGCACTTCT 540 ACAAGCGAGG AAACATCTAC CCTGGAAATG ATACCTTTGA CATCGATCCA GAAATTGAAA 600 CTGAGTGTTT CTTTGTGGAG CCAGATGAAC CTTTTCACAT TGGGACACCA GCAGAAAATA 660 AACTGAACTT AACACTGGAC TTCCACAGAC TCCTAACAGT GGAGCTTCAG TTTAAACTGA 720 AAGCCATTAA TCTGCAGACA GTTCGTCATC AAGAACTCCC TGACTGTTAT GACTTTACTC 780 TGACTATAAC ATTTGACAAC AAGGCCCATA GTGGAAGAAT TAAAATAAGT TTAGATAATG 840 ACATTTCCAT CAGAGAATGT AAAGACTGGC ATGTATCTGG ATCAATTCAG AAGAACACTC 900 ATTACATGAT GATCTTTGAT GCCTTTGTCA TTCTGACTTG CTTGGTTTCA TTAATCCTCT 960 GCATTAGATC TGTGATTAGA GGACTTCAGC TTCAGCAGGA GTTTGTCAAT TTTTTCCTCC 1020 TCCATTATAA GAAGGAAGTT TCTGTTTCTG ATCAAATGGA ATTTGTCAAT GGATGGTACA 1080 TTATGATTAT TATTAGTGAC ATATTGACAA TCATTGGATC AATTCTAAAA ATGGAAATCC 1140 AAGCTAAGAG TCTAACTAGT TATGATGTCT GTAGCATACT TCTTGGGACT TCTACCATGC 1200 TCGTGTGGCT TGGAGTCATC CGATACCTCG GTTTCTTTGC AAAGTACAAC CTCCTCATTT 1260 TGACCCTTCA GGCAGCGCTG CCCAATGTCA TCAGGTTCTG CTGCTGTGCA GCTATGATTT 1320 ACTTAGGTTA CTGCTTCTGT GGATGGATCG TGCTGGGGCC TTACCATGAC AAGTTTCGTT 1380 CTCTGAACAT GGTCTCTGAG TGCCTTTTCT CTCTGATAAA TGGAGATGAT ATGTTTGCCA 1440 CGTTTGCAAA AATGCAGCAA AAAAGTTACT TAGTCTGGCT GTTTAGTAGA ATTTACCTCT 1500 ACTCATTCAT CAGCCTCTTT ATATATATGA TTTTAAGTCT TTTCATTGCA CTGATCACTG 1560 ATACATACGA AACAATTAAG CAATACCAAC AAGATGGCTT CCCAGAGACT GAACTTCGTA 1620 CATTTATATC AGAATGCAAA GATCTACCCA ACTCTGGAAA ATACAGATTA GAAGATGACC 1680 CTCCAGTATC TTTATTCTGC TGTTGTAAAA AGTAGCTATC AGGTTTATCT GTACTTTAGA 1740 GGAAAATATA ATGTGTAGCT GAGTTGGAAC ACTGTGGATA TTCTGAGATC AGATGTAGTA 1800 TGTTTGGAGA CTGTTATTTT GAGCTAATTG AGACCTATAA TTCACCAATA ACTGTTTATA 1860 TTTTTAAAAG CAATATTTAA TGTCTTTGCA ACTTTATGCT 1900 Seq ID NO : 187 DNA Sequence Nucleic Acid Accession # : Nom 000114. 1 Coding sequence : 194.. 910 1 11 21 31 41 51 CGGGTAGCGC GCTCTGAAAG TTTATGACCG CCGCAGCCAA CTCCTGGCCG GAGCTGGAGA 60 CGCAGCGAGC GATCGGCCGG CCTCGAACCC CCACAGCTGG AGGGCGAGGC CAGCTGTACC 120 CGGCCCCAGT GCCCTTTCGC GGCCACAAGC GGCCGTCCTC CTGGTCCGGT GCTCCGGCGC 180 CTGATCTAGG TTCATGGAGC CGGGGCTGTG GCTCCTTTTC GGGCTCACAG TGACCTCCGC 240 CGCAGGATTC GTGCCTTGCT CCCAGTCTGG GGATGCTGGC AGGCGCGGCG TGTCCCAGGC 300 CCCCACTGCA GCCAGATCTG AGGGGGACTG TGAAGAGACT GTGGCTGGCC CTGGCGAGGA 360 GACTGTGGCT GGCCCTGGCG AGGGGACTGT GGCCCCGACA GCACTGCAGG GTCCAAGCCC 420 TGGAAGCCCT GGGCAGGAGC AGGCGGCCGA GGGGGCCCCT GAGCACCACC GATCCAGGCG 480 CTGCACGTGC TTCACCTACA AGGACAAGGA GTGTGTCTAC TATTGCCACC TGGACATCAT 540 TTGGATCAAC ACTCCCGAAC AGACGGTGCC CTATGGACTG TCCAACTACA GAGGAAGCTT 600 CCGGGGCAAG AGGTCTGCGG GGCCACTTCC AGGGAATCTG CAGCTCTCAC ATCGGCCACA 660 CTTGCGCTGC GCTTGTGTGG GGAGATATGA CAAGGCCTGC CTGCACTTTT GCACCCAAAC 720 TCTGGACGTC AGCAGTAATT CAAGGACGGC AGAAAAAACA GACAAAGAAG AGGAAGGGAA 780 GGTTGAAGTC AAGGACCAAC AAAGCAAGCA GGCTTTAGAC CTCCACCATC CAAAGCTCAT 840 GCCCGGCAGT GGACTCGCCC TCGCTCCATC TACCTGCCCC CGCTGCCTCT TTCAGGAAGG 900 AGCCCCTTAG GAGGACAGGC CTGCAGCTCC AATTTCATGC AGGAAATTGG TTTTGGAGAG 960 TTTTGGCAAG TTGGAAAGCC ACTTACTGGC TTTTGACATG ACTTCTCTTG GAGAATAAGT 1020 GGACTCCAAG CTAACTCTTT GCAAATGTAA ACACATGTCC ATCTTGTTAA TAAATGCAAA 1080 ATGCCCGTGC AGCAGAAGCA TGCGACTTTC ATATCCTTGC CTAGAATAGG CTGCATGGTG 1140 TATGTCAGTG AGGGCCACGA GGCGTCGGCT TTAGACACAG ATCATAGCTC TACAGGAGTT 1200 TATGAATTTG AAGCTTATGG GATTTTGGCA GAGAAATTTT CAGCTGTGCT TGATACCCAC 1260 CAAAAGAATG TATCTCGAAA GAATGAAGGA AGAAGAAAAA AGGATCCTTG ATGTTTGTGA 1320 CAAGAAAATG AGAAAGTTAG TATCTGCAAT ACAGAGCTTG TTCCTGTTCA GTGACTGACC 1380

CTCTGTATTC TGTATAGACA CCAGGCCGAT ACACAGTGGA GTTCCCAGGC CTTGTTTGCA 1440 GGAAGCCGAC TGTAAAGACA GCCCCAGCTC AAGGCTATTA GGTTGAATAT TTGCTTTCAT 1500 GAGTAAATGT GGATCTTTGG GGAATGGCTT CAAAATAAGT CACGAACACA AATTCTTTGT 1560 AAATTATGTA AATTCCTGTT TATATAAATT GGCAACAACT TATACCGTCT GACAGTTCAA 1620 AATCTCTTTC AGCTGCGCTC TTCCCACCGA GCCGAGCTTA CTGTGAGTGT GGAGATGTTA 1680 TCCCACCATG TAAAGTCGCC TGCGCAGGGG AGGGCTGCCC ATCTCCCCAA CCCAGTCACA 1740 GAGAGATAGG AAACGGCATT TGAGTGGGTG TCCAGGGCCC CGTAGAGAGA CATTTAAGAT 1800 GGTGTATGAC AGAGCATTGG CCTTGACCAA ATGTTAAATC CTCTGTGTGT ATTTCATAAG 1860 TTATTACAGG TATAAAAGTG ATGACCTATC ATGAGGAAAT GAAAGTGGCT GATTTGCTGG 1920 TAGGATTTTG TACAGTTTAG AGAAGCGATT ATTTATTGTG AAACTGTTCT CCACTCCAAC 1980 TCCTTTATGT GGATCTGTTC AAAGTAGTCA CTGTATATAC GTATAGAGAG GTAGATAGGT 2040 AGGTAGATTT TAAATTGCAT TCTGAATACA AACTCATACT CCTTAGAGCT TGAATTACAT 2100 TTTTAAAATG CATATGTGCT GTTTGGCACC GTGGCAAGAT GGTATCAGAG AGAAACCCAT 2160 CAATTGCTCA AATACTCAGA AAGTACTGTC AAAAGCCTAA TAAAAAACCT AAAGTTTGCT 2220 CTG 2223 Seq ID NO : 188 DNA Sequence Nucleic Acid Accession # : NM 005356. 2 Coding sequence : 52.. 1581 1 11 21 31 41 51 CGCCTGGACC ATGTGAATGG GGCCAGAGGG CTCCCGGGCT GGGCAGGGAC CATGGGCTGT 60 GGCTGCAGCT CACACCCGGA AGATGACTGG ATGGAAAACA TCGATGTGTG TGAGAACTGC 120 CATTATCCCA TAGTCCCACT GGATGGCAAG GGCACGCTGC TCATCCGAAA TGGCTCTGAG 180 GTGCGGGACC CACTGGTTAC CTACGAAGGC TCCAATCCGC CGGCTTCCCC ACTGCAAGAC 240 AACCTGGTTA TCGCTCTGCA CAGCTATGAG CCCTCTCACG ACGGAGATCT GGGCTTTGAG 300 AAGGGGGAAC CACTCCGCAT CCTGGAGCAG AGCGGCGAGT GGTGGAAGGC GCAGTCCCTG 360 ACCACGGGCC AGGAAGGCTT CATCCCCTTC AATTTTGTGG CCAAAGCGAA CAGCCTGGAG 420 CCCGAACCCT GGTTCTTCAA GAACCTGAGC CGCAAGGACG CGGAGCGGCA GCTCCTGGCG 480 CCCGGGAACA CTCACGGCTC CTTCCTCATC CGGGAGAGCG AGAGCACCGC CGGGTCCTTT 540 TCACTGTCGG TCCGGGACTT CGACCAAAAC CAGGGAGAGG TGGTGAAACA TTACAAGATC 600 CGTAATCTGG ACAACGGTGG CTTCTACATC TCCCCTCGAA TCACTTTTCC CGGCCTGCAT 660 GAACTGGTCC GCCATTACAC CAATGCTTCA GATGGGCTGT GCACACGGTT GAGCCGCCCC 720 TGCCAGACCC AGAAGCCCCA GAAGCCGTGG TGGGAGGACG AGTGGGAGGT TCCCAGGGAG 780 ACGCTGAAGC TGGTGGAGCG GCTGGGGGCT GGACAGTTCG GGGAGGTGTG GATGGGGTAC 840 TACAACGGGC ACACGAAGGT GGCGGTGAAG AGCCTGAAGC AGGGCAGCAT GTCCCCGGAC 900 GCCTTCCTGG CCGAGGCCAA CCTCATGAAG CAGCTGCAAC ACCAGCGGCT GGTTCGGCTC 960 TACGCTGTGG TCACCCAGGA GCCCATCTAC ATCATCACTG AATACATGGA GAATGGGAGT 1020 CTAGTGGATT TTCTCAAGAC CCCTTCAGGC ATCAAGTTGA CCATCAACAA ACTCCTGGAC 1080 ATGGCAGCCC AAATTGCAGA AGGCATGGCA TTCATTGAAG AGCGGAATTA TATTCATCGT 1140 GACCTTCGGG CTGCCAACAT TCTGGTGTCT GACACCCTGA GCTGCAAGAT TGCAGACTTT 1200 GGCCTAGCAC GCCTCATTGA GGACAACGAG TACACAGCCA GGGAGGGGGC CAAGTTTCCC 1260 ATTAAGTGGA CAGCGCCAGA AGCCATTAAC TACGGGACAT TCACCATCAA GTCAGATGTG 1320 TGGTCTTTTG GGATCCTGCT GACGGAAATT GTCACCCACG GCCGCATCCC TTACCCAGGG 1380 ATGACCAACC CGGAGGTGAT TCAGAACCTG GAGCGAGGCT ACCGCATGGT GCGCCCTGAC 1440 AACTGTCCAG AGGAGCTGTA CCAACTCATG AGGCTGTGCT GGAAGGAGCG CCCAGAGGAC 1500 CGGCCCACCT TTGACTACCT GCGCAGTGTG CTGGAGGACT TCTTCACGGC CACAGAGGGC 1560 CAGTACCAGC CTCAGCCTTG AGAGGAGGCC TTGAGAGGCC CTGGGGTTCT CCCCCTTTCT 1620 CTCCAGCCTG ACTTGGGGAG ATGGAGTTCT TGTGCCATAG TCACATGGCC TATGCACATA 1680 TGGACTCTGC ACATGAATCC CACCCACATG TGACACATAT GCACCTTGTG TCTGTACACG 1740 TGTCCTGTAG TTGCGTGGAC TCTGCACATG TCTTGTGCAT GTGTAGCCTG TGCATGTATG 1800 TCTTGGACAC TGTACAAGGT ACCCCTTTCT GGCTCTCCCA TTTCCTGAGA CCACCAGAGA 1860 GAGGGGAGAA GCCTGGGATT GACAGAAGCT TCTGCCCACC TACTTTTCTT TCCTCAGATC 1920 ATCCAGAAGT TCCTCAAGGG CCAGGACTTT ATCTAATACC TCTGTGTGCT CCTCCTTGGT 1980 GCCTGGCCTG GCACACATCA GGAGTTCAAT AAATGTCTGT TGATGACTGC CG 2032 Seq ID NO : 189 DNA Sequence Nucleic Acid Accession # : NM 014654. 1 Coding sequence : 1504.. 2658 1 11 21 31 41 51 CTGAGATGCA GGCCCAGCGC TGGCGCAGTG AGAACTTCGA GAGACCCGTG GACCTGGAGG 60 GCTCTGGGGA TGATGACTCC TTTCCCGATG ATGAACTGGA TGACCTCTAC TCGGGGTCGG 120 GCTCGGGCTG TAAGTACCCC CCTCCCTACC TCTGCCTGGG GGCAGTGACC AGTCTGTATC 180 CAGCCTCAAC TCTGAGAAGC CCACGGGGGG CTTGCTTCAG TGAGGCAGGG GGCATTCACT 240 GCCTGGGTCA GGCAAGTTCT TCTTGCTCTG GATCCCCAGA ACAAGAAGGG CAGAACATCC 300 TTCTGGGGAT AGAACAAGAC CTGGGAGGAC CTCAGGGCCC AGAATGTCCA GGTCTCCAGG 360 GTCCCACGTC TGCATCTTTG TGTGTGCTAT GTGGCTTTCT CTGCAGACCT TGCTTGGTTC 420 CGGTGGTCCC GTCAGGTGCA ATAAGCTGTG GCCAATGGTG GGGTTAGGGC AGTGATGACA 480 CAGGGCAGGT GCTTCAAGTG GTGCCTGGGA TGGCCCCGCC CTGGGGAAGG GGAGCCAGGT 540 CAGCTGGGTC TAGCAGAATC TCGGGAGAGA AGGGCACCGC GAACCCCACT CTGCCATGTA 600 GCAACTGTGT GCCCCTCGGT GCTCCCCCTC CCTGAATCCC TGTATTTTCA CCTGTGGATG 660 GTGAGAAATA CGACTTCTTC TCAGTGCCTC TAGGAGGGTT TGGGATAGGA AGCTGGGGTC 720 TGGCACAGAG GAGGAGCTCT CAAAATGGTA GCAAAAAGAA GGCAGCTGAG ACTGGGCCCA 780 GTGAGGGCAC GGGCTGGCAT CTGAGGAGAT GGTACGGGGT CTGCACGCCA CAGAGCTGGC 840 TCCCCACAGC CCTCGCCTCT GGTCTCCCCT CCTTAGCCAA GTCCTTTGAG CCTCTTTCAA 900 ATTAATCTTT GTAAAACCCG TTTATATTGG GTCACATCTC TATTCGCAAA GTTCCCTGGC 960 TCCCCTCCCT CCTGCCTGGT TCCGAGCCCA GGAGCTGGCT GTGGCTTCTC CCTCCCCCAT 1020 CCCCTACTCC CCGTCTCATT TCCTCCCAAG TTCCTTCACT GTCCCGGCTT TGCGTCAGCC 1080 AGATTGCTCA AGCAGTTCCC CTGCCTCAAG GGCTTCTTTT CCCTTTTACC CTCCGCCTCT 1140 GCCTCTGGGG GAAGCCCTTA GTGTACCACC CCTGCCTTGA GCTTGTGGTA GGGGTGCCTT 1200 TGGGGTCTGA CTCTTCCCAG AATGCCACTC CTGTGTTCCC CTGCAAGCCC CAGCAAGTTT 1260 TGCAGCCAGT AGCGCCTCAG TTGCTGCTGC CTGGATTCAA CCTCATAGAA ACTGTAGGCT 1320 GGGTGGGCAG GAATAGTCAA GGAAGGCTTC CCGGGAGAGG CGGCCCCCAG AATTTTTGAC 1380

TTGGCAGAGA GAAGTTGGGG AACATCAGCA ACTGACCACC TTTAGCTGGC TGTGCCTTCC 1440 TCCTTTCTCT CATCTTTTCT GGGAAAATTG GGTAAAGAGA GGGGGTTGGG AGACCTAATC 1500 TTGATGGCCA TTGCTTACCT GGGATCCTCA TGCCCCTCAC AACCACCCAG CTCCCTAGCT 1560 CTCTCCCTCT CCCCCACCCC CTCAGACTTC GAGCAGGAGT CGGGCATTGA GACAGCCATG 1620 CGCTTCAGCC CAGATGTAGC CCTGGCGGTG TCCACCACAC CTGCGGTGCT GCCCACCACG 1680 AACATCCAGC CTGTGGGCAC ACCATTTGAA GAGCTCCCCT CTGAGCGCCC CACCCTGGAG 1740 CCAGCCACCA GCCCCCTGGT GGTGACAGAA GTCCCGGAAG AGCCCAGCCA GAGAGCCACC 1800 ACCGTCTCCA CTACCATGGC TACCACTGCT GCCACAAGCA CAGGGGACCC GACTGTGGCC 1860 ACAGTGCCTG CCACAGTGGC CACCGCCACC CCCAGCACCC CTGCAGCACC CCCTTTTACG 1920 GCCACCACTG CTGTTATAAG GACCACTGGC GTACGGAGGC TTCTGCCTCT CCCACTGACC 1980 ACAGTGGCTA CGGCACGGGC CACTACCCCC GAGGCGCCCT CCCCGCCCAC CACGGCGGCT 2040 GTCTTGGACA CCGAGGCCCC AACACCCAGG CTGGTCAGCA CAGCTACCTC CCGGCCAAGA 2100 GCCCTTCCCA GGCCGGCCAC CACCCAGGAG CCTGACATCC CTGAGAGGAG CACCCTGCCC 2160 CTGGGGACCA CTGCCCCTGG ACCCACAGAG GTGGCTCAGA CCCCAACTCC AGAGACCTTC 2220 CTGACCACAA TCCGGGATGA GCCAGAGGTT CCGGTGAGTG GGGGGCCCAG TGGAGACTTC 2280 GAGCTGCCAG AAGAAGAGAC CACACAACCA GACACAGCCA ATGAGGTGGT AGCTGTGGGA 2340 GGGGCTGCGG CCAAGGCATC ATCTCCACCT GGGACACTGC CCAAGGGTGC CCGCCCGGGC 2400 CCTGGCCTCC TGGACAATGC CATCGACTCG GGCAGCTCAG CTGCTCAGCT GCCTCAGAAG 2460 AGTATCCTGG AGCGGAAGGA GGTGCTCGTA GCTGTGATTG TGGGCGGGGT GGTGGGCGCC 2520 CTCTTTGCTG CCTTCTTGGT CACACTGCTC ATCTATCGTA TGAAGAAAAA GGATGAGGGC 2580 AGCTACACGC TGGAGGAACC CAAGCAGGCG AGCGTCACAT ACCAGAAGCC TGACAAGCAG 2640 GAGGAGTTCT ATGCCTAGTG GAGCCACAGT GCCTCCCTGC AGCCTCAACA CCACCCTGCT 2700 GTCCAGTCCC CAGCCTGGCC CCACCAGCCC AAGCCTGGGA CTGGGCCTGG AACCTGGCCC 2760 CAGTTCTTCT CTGCCCTCTC TCCCAAGGTC TGCCCAGGCT GCCAGCCTCA CACAGATCTT 2820 CCCCGAGGAA GAGGGGCTGC TGCCATCTGC CCCAGACTGT GCCCTTACGA GCTCATCTCT 2880 TGTTCCCCTC ATCCCTGCCA CCAGTCTGGG GCTTCAGGAC CTCATGTCAG ATGGATGGGA 2940 GGAAGAAAGC TCCTGATTGG CTGGTGGTGG AAGAAAGGGT GGGGCTTGAG ATGAGCCTGA 3000 GCCCTGACTT GGCACCCACA GTGCTCACTG AGATCTCCTT TTTGGGGCAG AGAGGCACTC 3060 AGGCTGGTTT CCAGGACAAA CATTTGGTAA ACACAGCCCT TGAAATCATC TAGACACTGC 3120 AACCTCTTGC TCGTATCCCA GGGCCTCTCT CTAGCTGGGT GAGAGGGTGT CCCTTGTCAC 3180 CAGCCTGTTT TGTCCTGGTC TCTCTGGGGT TGTTGAATCT CTCCTCTTGC CTGCCAAGTA 3240 CACATGTACC CAGACTTCAT TTCTTTCTGC ATCTTCCCCC AAGAAACAGC TTCCTGAGGG 3300 TGCTGGGGCA GCCACTGGTG AGGAGGGGCT GCTCTGATGT CCCTCCTATG AGGGGACTCT 3360 GCACAGACAC CATTGCCCAC ACTATCACCA TATTTTCACT CAGTCACACA CAAGACAAAA 3420 GCATGCAATG ACAAAACCAT ACGCAATCCT GACCGCCCAG CCAATCAAGA CATATCACAG 3480 AACACACGCG TCCTTCCAAG AATGTTTATC CTCATGCATC ACTTACACAC CCCCAGACAC 3540 GTACTGCAAT GCAAGTCACT AGTCATGGTC ACATGACAGT GACAGTGTGG CCTCCTCCTA 3600 CCCCAAATAC ACCCACACTC TGGCACCACA CACATTGTCT CCAGCTTTCA GGCTTACTGG 3660 GGAGGGTGGA ATCGAGCCAG AACAATCAGC CCATATTGGG TCCCCCTAAG TTGCCCCGTC 3720 ATACTCAGTC CCATGCCATG GTGCCCACAC CAACCATGCA GCCACCAACC CCAGCCAGTG 3780 TCAGACACAA TCCCATGTGG ATGCACAGTC TCACTCCACA TGACCTGCTC TCAATGCTGG 3840 AGGGAAACAG GCAGGCCCTT GCCTTTCTCG GAAAAAGTGT GGGGCCACAG CCCTTTTAGG 3900 GCATTGCATG CAGGTGGGCC TGGCTTCACC CCTACCTGCT TCCTCCCCAC CGCAGCTGGC 3960 AGAGGGGGAG GTTTGGGGCC AGACCCCCAC TAGCTGGGAG CCTGGGGGCT CCTCTAAGGC 4020 TGAGGAAGGA AATTTGGCCC CAGGTTGTTG GGGGGTCTTG GGTCTCCCAG GACGGAAGGC 4080 CCAGGGCAGG GAGGGGGCAT GTGGTTGGGC TCCTTTATCT CCCTGTGTCC CCTTCCTGCT 4140 TTGAGCTAGG GGGCTGACTC TGCCTCCCAG GACACAAGTC TCCAAAGTGC CTGTGAGGGC 4200 GGGCCCTCCG CACCCTCTGC CCTCTGCCTG GCAGGCCAAC CTCAGCCCAC CTGCCCAGAG 4260 GCCCTCCCTG TGGACACCCC CTCACCTATT TGGCCAAACA ATTCTGGCTG CAGCTTCAGG 4320 GGCCATGGCT GGAAGCAGCC CCTGCAGATC CCTCAGGCCC CGAGGTCAGG GTTTGAGGGA 4380 TGAGACCAGG TGATAGTGGG GGAGGGGTTA CTTCCTTTGT TACCTAGCAA GTAGGGCTAT 4440 TTCCATCGGT ATTTTAAATG TGGGGTCACA GATCTTTTGG GGAGGGTGTG CTTGGCAGGG 4500 GGCCTCTTGG AGCCAAAGGG ATGTGGTGTG AGTTGCGATT GGCTGGCACT CACACCCCCA 4560 CCCCTCACCC ACATCCCAGA TTCAAGTCAG GAAGGCAGGT TTTATTTCAG GGCCCTTTTC 4620 AAGATGCCCT GGCAGCAGAT TTCTGCAGGA TGAGGGGTAG CGGTGTGTAG GCAGTGAGGG 4680 GGAGGTTCCA GGGGCTGTCC CACAGCCTGT CTTTTCCAGG CTGGGCTCCA TCTTCCAGTC 4740 CCAAAACCCT CCTTCACAGG GCCCAGAGGC TTGTGAGGAA GCCAGGTGGA CCCAGCCTTG 4800 GAAGAGTGGG CATGGGGGGC CCCTGATATC TGGAGGGGGC GGGTTGGCCT CAGTCATCTT 4860 TGGAGCAGAA GGGCTGGGTC CTGGGGCCAC AGACCACAAG GCTCAGCCTC CCTACCCTGC 4920 TCCCTGGGGT GCTGCTGTCT TGGAGAGCAC AGCTCTGGTG AGACGGCCTG GGCAGGCCGA 4980 GGCTGAGAAA CCAGGGAGGA TAGAGGAGAA AAGGGCTTGG GCCCCCAGCC CCAGAAGATG 5040 CTGGGCCCCA GGTGGGAGAC CCAACAGTGG GTGCAGTTTC TCAGTGGGGC TGGAGCCAAT 5100 GGTGGGGGTG GCCCCGGCAG GCCTGGCTCC TCACATCCCA GGGGTTGGCT TCTGATTTGG 5160 GGCTTGGGCT CCAGGCACTG GCTTCTCTTC TCTGTGTCCT TAGCATTTGA GAGAAGAGGC 5220 CAGGGGCCTT GTTCATGGAT CCCTGGACCC AAGGCAGATG TCCAGGCTTT ATCCTCCTGA 5280 GGATGAGGAG TCTGACCAGC CCAAATCTGC CCTGGCCGGC CTGACCGGGG CAAGGCAGTC 5340 CAAGAGAGTT CAGTGAGGAC CAGCTAGGCT CTCCCAGGTG CAATGTGGGT GCAGGGCCCT 5400 CATGTCCCCC TACCCCTGCC TGTGATGGAG TGTTCTGAGG GGCTTTGGCA TTTGCTGGAA 5460 GCACAGGGAG TTCCAAATGA GAGGGAGCTT CTGTGGCTTG AGAGCCTCTG GGGCCTTGGC 5520 TGCCAGAGCA CGAGGCAGGC CAGGACCTGG AGAGCCCAGA CCCTGTCTCC AGGAGGCCAG 5580 GAGGCCAGAT GGGGGCCTTG CCTGAAAGAC TGGTCCCCTT GATCGCTGGA GGCATGTGGG 5640 TGGCAACCAG GGCTGGGCAG GGCTTAGGGT GTGTGGGCCA AACCCCCCTG GGGTTGGCAA 5700 AGCCGCCTGT CAGGCCTCCT GGTGGGGGCC CCTGGACACA GGGAGCAGAC CCTCTGCCTC 5760 ATGGGGTAGG AGTGGCTGCC TCCTGTGTTC TCTGGATTTC TTCTCCCAAC AACTACAACC 5820 CTGGACTTGC CTCCCCAGGC CTCTTGCCTG TAAATAGAAG CCCGCAAACT GTACAGATTT 5880 ACAGAGGCAT CGAGACTGGG CCCTGGGAGT TGCCATCTGA GAGCCGATGG CCCCAGCATC 5940 CCCCAGGTGC CTGCCTGGCA CCACAGTGAC CCTGGCCTCA GCGTGGCAAA TGCATGTAAA 6000 TATTTTTCGT AGGCAGCGTG GCTCCAGAGA GCCCCCTGAA GACAGTGTCC CTCCCTCCTG 6060 TGAGTCCTTT CTCCTGTACA GAACCTGCCT GGGGTGGGTG GGGGTCTGCC ATTCCCTCCC 6120 CCAGGCCTTC CCTGCCCCTT CTCTCCCCTG TAACCTGTTT ATTAACCATA CCTGTCCTGA 6180 GTTCATGGCC AAAACCTTAA ATAAGAAAAA CAAAAGAAAA AGACAGTGGA AAAAAGAGAC 6240 CAAGGCGCCT GCCCCACTGC GGGTACTCTC CTGTTCCAGC CTTGTGAAGG AACTGGTTTT 6300 GTTTTTGTTT TTGTTTTTTT TTTTTTTGTT TGTTTGTTTG TTTTTTAACA CTTCCTGTGC 6360 TGTGCCCATT TATAAGAGGA AATAAAATTA AGCTGAAATG 6400

Seq ID NO : 190 DNA Sequence Nucleic Acid Accession # : NM 006917. 2 Coding sequence : 189.. 1580 1 11 21 31 41 51 CTCCGATCTA GAGGCAGATT CCTGACTAAT CCCAGAGGGC TGGCCCAGCC TGTGCTCCCC 60 GGGCTGCTAG GAAGCGATGA CCACTCTTGT TAGCCCAAGT TGAAGAAAGC CGGGCTGTGC 120 CTGGGAGCCG AGAGAGGCGG TAATATTTAG AAGCTGCACA GGAGAGGAAC ATGAACTGAC 180 GAGTAAACAT GTATGGAAAT TATTCTCACT TCATGAAGTT TCCCGCAGGC TATGGAGGCT 240 CCCCTGGCCA CACTGGCTCT ACATCCATGA GCCCATCAGC AGCCTTGTCC ACAGGGAAGC 300 CAATGGACAG CCACCCCAGC TACACAGATA CCCCAGTGAG TGCCCCACGG ACTCTGAGTG 360 CAGTGGGGAC CCCCCTCAAT GCCCTGGGCT CTCCATATCG AGTCATCACC TCTGCCATGG 420 GCCCACCCTC AGGAGCACTT GCAGCGCCTC CAGGAATCAA CTTGGTTGCC CCACCCAGCT 480 CTCAGCTAAA TGTGGTCAAC AGTGTCAGCA GTTCAGAGGA CATCAAGCCC TTACCAGGGC 540 TTCCCGGGAT TGGAAACATG AACTACCCAT CCACCAGCCC CGGATCTCTG GTTAAACACA 600 TCTGTGCCAT CTGTGGAGAC AGATCCTCAG GAAAGCACTA CGGGGTATAC AGTTGTGAAG 660 GCTGCAAAGG GTTCTTCAAG AGGACGATAA GGAAGGACCT CATCTACACG TGTCGGGATA 720 ATAAAGACTG CCTCATTGAC AAGCGTCAGC GCAACCGCTG CCAGTACTGT CGCTATCAGA 780 AGTGCCTTGT CATGGGCATG AAGAGGGAAG CTGTGCAAGA AGAAAGACAG AGGAGCCGAG 840 AGCGAGCTGA GAGTGAGGCA GAATGTGCTA CCAGTGGTCA TGAAGACATG CCTGTGGAGA 900 GGATTCTAGA AGCTGAACTT GCTGTTGAAC CAAAGACAGA ATCCTATGGT GACATGAATA 960 TGGAGAACTC GACAAATGAC CCTGTTACCA ACATATGTCA TGCTGCTGAC AAGCAGCTTT 1020 TCACCCTCGT TGAATGGGCC AAGCGTATTC CCCACTTCTC TGACCTCACC TTGGAGGACC 1080 AGGTCATTTT GCTTCGGGCA GGGTGGAATG AATTGCTGAT TGCCTCTTTC TCCCACCGCT 1140 CAGTTTCCGT GCAGGATGGC ATCCTTCTGG CCACGGGTTT ACATGTCCAC CGGAGCAGTG 1200 CCCACAGTGC TGGGGTCGGC TCCATCTTTG ACAGAGTCCT AACTGAGCTG GTTTCCAAAA 1260 TGAAAGACAT GCAGATGGAC AAGTCGGAAC TGGGATGCCT GCGAGCCATT GTACTCTTTA 1320 ACCCAGATGC CAAGGGCCTG TCCAACCCCT CTGAGGTGGA GACTCTGCGA GAGAAGGTTT 1380 ATGCCACCCT TGAGGCCTAC ACCAAGCAGA AGTATCCGGA ACAGCCAGGC AGGTTTGCCA 1440 AGCTGCTGCT GCGCCTCCCA GCTCTGCGTT CCATTGGCTT GAAATGCCTG GAGCACCTCT 1500 TCTTCTTCAA GCTCATCGGG GACACCCCCA TTGACACCTT CCTCATGGAG ATGTTGGAGA 1560 CCCCGCTGCA GATCACCTGA GCCCCACCAG CCACAGCCTC CCCACCCAGG ATGACCCCTG 1620 GGCAGGTGTG TGTGGACCCC CACCCTGCAC TTTCCTCCAC CTCCCACCCT GACCCCCTTC 1680 CTGTCCCCAA AATGTGATGC TTATAATAAA GAAAACCTTT CTACAAAAAA AAAAAAAAAA 1740 AA 1742 Seq ID NO : 191 DNA Sequence Nucleic Acid Accession # : Nom 002185. 1 Coding sequence : 23.. 1402 1 11 21 31 41 51 CTCTCTCTCT ATCTCTCTCA GAATGACAAT TCTAGGTACA ACTTTTGGCA TGGTTTTTTC 60 TTTACTTCAA GTCGTTTCTG GAGAAAGTGG CTATGCTCAA AATGGAGACT TGGAAGATGC 120 AGAACTGGAT GACTACTCAT TCTCATGCTA TAGCCAGTTG GAAGTGAATG GATCGCAGCA 180 TTCACTGACC TGTGCTTTTG AGGACCCAGA TGTCAACACC ACCAATCTGG AATTTGAAAT 240 ATGTGGGGCC CTCGTGGAGG TAAAGTGCCT GAATTTCAGG AAACTACAAG AGATATATTT 300 CATCGAGACA AAGAAATTCT TACTGATTGG AAAGAGCAAT ATATGTGTGA AGGTTGGAGA 360 AAAGAGTCTA ACCTGCAAAA AAATAGACCT AACCACTATA GTTAAACCTG AGGCTCCTTT 420 TGACCTGAGT GTCATCTATC GGGAAGGAGC CAATGACTTT GTGGTGACAT TTAATACATC 480 ACACTTGCAA AAGAAGTATG TAAAAGTTTT AATGCATGAT GTAGCTTACC GCCAGGAAAA 540 GGATGAAAAC AAATGGACGC ATGTGAATTT ATCCAGCACA AAGCTGACAC TCCTGCAGAG 600 AAAGCTCCAA CCGGCAGCAA TGTATGAGAT TAAAGTTCGA TCCATCCCTG ATCACTATTT 660 TAAAGGCTTC TGGAGTGAAT GGAGTCCAAG TTATTACTTC AGAACTCCAG AGATCAATAA 720 TAGCTCAGGG GAGATGGATC CTATCTTACT AACCATCAGC ATTTTGAGTT TTTTCTCTGT 780 CGCTCTGTTG GTCATCTTGG CCTGTGTGTT ATGGAAAAAA AGGATTAAGC CTATCGTATG 840 GCCCAGTCTC CCCGATCATA AGAAGACTCT GGAACATCTT TGTAAGAAAC CAAGAAAAAA 900 TTTAAATGTG AGTTTCAATC CTGAAAGTTT CCTGGACTGC CAGATTCATA GGGTGGATGA 960 CATTCAAGCT AGAGATGAAG TGGAAGGTTT TCTGCAAGAT ACGTTTCCTC AGCAACTAGA 1020 AGAATCTGAG AAGCAGAGGC TTGGAGGGGA TGTGCAGAGC CCCAACTGCC CATCTGAGGA 1080 TGTAGTCGTC ACTCCAGAAA GCTTTGGAAG AGATTCATCC CTCACATGCC TGGCTGGGAA 1140 TGTCAGTGCA TGTGACGCCC CTATTCTCTC CTCTTCCAGG TCCCTAGACT GCAGGGAGAG 1200 TGGCAAGAAT GGGCCTCATG TGTACCAGGA CCTCCTGCTT AGCCTTGGGA CTACAAACAG 1260 CACGCTGCCC CCTCCATTTT CTCTCCAATC TGGAATCCTG ACATTGAACC CAGTTGCTCA 1320 GGGTCAGCCC ATTCTTACTT CCCTGGGATC AAATCAAGAA GAAGCATATG TCACCATGTC 1380 CAGCTTCTAC CAAAACCAGT GAAGTGTAAG AAACCCAGAC TGAACTTACC GTGAGCGACA 1440 AAGATGATTT AAAAGGGAAG TCTAGAGTTC CTAGTCTCCC TCACAGCACA GAGAAGACAA 1500 AATTAGCAAA ACCCCACTAC ACAGTCTGCA AGATTCTGAA ACATTGCTTT GACCACTCTT 1560 CCTGAGTTCA GTGGCACTCA ACATGAGTCA AGAGCATCCT GCTTCTACCA TGTGGATTTG 1620 GTCACAAGGT TTAAGGTGAC CCAATGATTC AGCTATTT 1658 Seq ID NO : 192 DNA Sequence Nucleic Acid Accession # : Nom 006272. 1 Coding sequence : 73.. 351 1 11 21 31 41 51 TGCCGCCCAG GACCCGCAGC AGAGACGACG CCTGCAGCAA GGAGACCAGG AAGGGGTGAG 60 ACAAGGAAGA GGATGTCTGA GCTGGAGAAG GCCATGGTGG CCCTCATCGA CGTTTTCCAC 120 CAATATTCTG GAAGGGAGGG AGACAAGCAC AAGCTGAAGA AATCCGAACT CAAGGAGCTC 180 ATCAACAATG AGCTTTCCCA TTTCTTAGAG GAAATCAAAG AGCAGGAGGT TGTGGACAAA 240 GTCATGGAAA CACTGGACAA TGATGGAGAC GGCGAATGTG ACTTCCAGGA ATTCATGGCC 300 TTTGTTGCCA TGGTTACTAC TGCCTGCCAC GAGTTCTTTG AACATGAGTG AGATTAGAAA 360 GCAGCCAAAC CTTTCCTGTA ACAGAGACGG TCATGCAAGA AAGCAGACAG CAAGGGCTTG 420 CAGCCTAGTA GGAGCTGAGC TTTCCAGCCG TGTTGTAGCT AATTAGGAAG CTTGATTTGC 480

TTTGTGATTG AAAAATTGAA AACCTCTTTC CAAAGGCTGT TTTAACGGCC TGCATCATTC 540 TTTCTGCTAT ATTAGGCCTG TGTGTAAGCT GACTGGCCCC AGGGACTCTT GTTAACAGTA 600 ACTTAGGAGT CAGGTCTCAG TGATAAAGCG TGCACCGTGC AGCCCGCCAT GGCCGTGTAG 660 ACCCTAACCC GGAGGGAACC CTGACTACAG AAATTACCCC GGGGCACCCT TAAAACTTCC 720 ACTACCTTTA AAAAACAAAG CCTTATCCAG CATTATTTGA AAACACTGCT GTTCTTTAAA 780 TGCGTTCCTC ATCCATGCAG ATAACAGCTG GTTGGCCGGT GTGGCCCTGC AAGGGCGTGG 840 TGGCTTCGGC CTGCTTCCCG GGATGCGCCT GATCACCAGG TGAACGCTCA GCGCTGGCAG 900 CGTCCTGGAA AAAGCAACTC CATCAGAACT CGCAATCCGA GCCAGCTCTG GGGGCTCCAG 960 CGTGGCCTCC GTGACCCATG CGATTCAAGT CGCGGCTGCA GGATCCTTGC CTCCAACGTG 1020 CCTCCAGCAC ATGCGGCTTC CGAGGGCACT ACCGGGGGCT CTGAGCCACC GCGAGGGCCT 1080 GCGTTCAATA AAAAG 1095 Seq ID NO : 193 DNA Sequence Nucleic Acid Accession # : Nom 006157. 1 Coding sequence : 103.. 2535 1 11 21 31 41 51 ( TAGCAAGTTT GGCGGCTCCA AGCCAGGCGC GCCTCAGGAT CCAGGCTCAT TTGCTTCCAC 60 CTAGCTTCGG TGCCCCCTGC TAGGCGGGGA CCCTCGAGAG CGATGCCGAT GGATTTGATT 120 TTAGTTGTGT GGTTCTGTGT GTGCACTGCC AGGACAGTGG TGGGCTTTGG GATGGACCCT 180 GACCTTCAGA TGGATATCGT CACCGAGCTT GACCTTGTGA ACACCACCCT TGGAGTTGCT 240 CAGGTGTCTG GAATGCACAA TGCCAGCAAA GCATTTTTAT TTCAAGACAT AGAAAGAGAG 300 ATCCATGCAG CTCCTCATGT GAGTGAGAAA TTAATTCAGC TGTTCCAGAA CAAGAGTGAA 360 TTCACCATTT TGGCCACTGT ACAGCAGAAG CCATCCACTT CAGGAGTGAT ACTGTCCATT 420 CGAGAACTGG AGCACAGCTA TTTTGAACTG GAGAGCAGTG GCCTGAGGGA TGAGATTCGG 480 TATCACTACA TACACAATGG GAAGCCAAGG ACAGAGGCAC TTCCTTACCG CATGGCAGAT 540 GGACAATGGC ACAAGGTTGC ACTGTCAGTT AGCGCCTCTC ATCTCCTGCT CCATGTCGAC 600 TGTAACAGGA TTTATGAGCG TGTGATAGAC CCTCCAGATA CCAACCTTCC CCCAGGAATC 660 AATTTATGGC TTGGCCAGCG CAACCAAAAG CATGGCTTAT TCAAAGGGAT CATCCAAGAT 720 GGGAAGATCA TCTTTATGCC GAATGGATAT ATAACACAGT GTCCAAATCT AAATCACACT 780 TGCCCAACCT GCAGTGATTT CTTAAGCCTG GTGCAAGGAA TAATGGATTT ACAAGAGCTT 840 TTGGCCAAGA TGACTGCAAA ACTAAATTAT GCAGAGACAA GACTTAGTCA ATTGGAAAAC 900 TGTCATTGTG AGAAGACTTG TCAAGTGAGT GGACTGCTCT ATCGAGATCA AGACTCTTGG 960 GTAGATGGTG ACCATTGCAG GAACTGCACT TGCAAAAGTG GTGCCGTGGA ATGCCGAAGG 1020 ATGTCCTGTC CCCCTCTCAA TTGCTCCCCA GACTCCCTCC CAGTACACAT TGCTGGCCAG 1080 TGCTGTAAGG TCTGCCGACC AAAATGTATC TATGGAGGAA AAGTTCTTGC AGAAGGCCAG 1140 CGGATTTTAA CCAAGAGCTG TCGGGAATGC CGAGGTGGAG TTTTAGTAAA AATTACAGAA 1200 ATGTGTCCTC CTTTGAACTG CTCAGAAAAG GATCACATTC TTCCTGAGAA TCAGTGCTGC 1260 CGTGTCTGTA GAGGTCATAA CTTTTGTGCA GAAGGACCTA AATGTGGTGA AAACTCAGAG 1320 TGCAAAAACT GGAATACAAA AGCTACTTGT GAGTGCAAGA GTGGTTACAT CTCTGTCCAG 1380 GGAGACTCTG CCTACTGTGA AGATATTGAT GAGTGTGCAG CTAAGATGCA TTACTGTCAT 1440 GCCAATACTG TGTGTGTCAA CCTTCCTGGG TTATATCGCT GTGACTGTGT CCCAGGATAC 1500 ATTCGTGTGG ATGACTTCTC TTGTACAGAA CACGATGAAT GTGGCAGCGG CCAGCACAAC 1560 TGTGATGAGA ATGCCATCTG CACCAACACT GTCCAGGGAC ACAGCTGCAC CTGCAAACCG 1620 GGCTACGTGG GGAACGGGAC CATCTGCAGA GCTTTCTGTG AAGAGGGCTG CAGATACGGT 1680 GGAACGTGTG TGGCTCCCAA CAAATGTGTC TGTCCATCTG GATTCACAGG AAGCCACTGC 1740 GAGAAAGATA TTGATGAATG TTCAGAGGGA ATCATTGAGT GCCACAACCA TTCCCGCTGC 1800 GTTAACCTGC CAGGGTGGTA CCACTGTGAG TGCAGAAGCG GTTTCCATGA CGATGGGACC 1860 TATTCACTGT CCGGGGAGTC CTGTATTGAC ATTGATGAAT GTGCCTTAAG AACTCACACC 1920 TGTTGGAACG ATTCTGCCTG CATCAACCTG GCAGGGGGTT TTGACTGTCT CTGCCCCTCT 1980 GGGCCCTCCT GCTCTGGTGA CTGTCCTCAT GAAGGGGGGC TGAAGCACAA TGGCCAGGTG 2040 TGGACCTTGA AAGAAGACAG GTGTTCTGTC TGCTCCTGCA AGGATGGCAA GATATTCTGC 2100 CGACGGACAG CTTGTGATTG CCAGAATCCA AGTGCTGACC TATTCTGTTG CCCAGAATGT 2160 GACACCAGAG TCACAAGTCA ATGTTTAGAC CAAAATGGTC ACAAGCTGTA TCGAAGTGGA 2220 GACAATTGGA CCCATAGCTG TCAGCAGTGT CGGTGTCTGG AAGGAGAGGT AGATTGCTGG 2280 CCACTCACTT GCCCCAACTT GAGCTGTGAG TATACAGCTA TCTTAGAAGG GGAATGTTGT 2340 CCCCGCTGTG TCAGTGACCC CTGCCTAGCT GATAACATCA CCTATGACAT CAGAAAAACT 2400 TGCCTGGACA GCTATGGTGT TTCACGGCTT AGTGGCTCAG TGTGGACGAT GGCTGGATCT 2460 CCCTGCACAA CCTGTAAATG CAAGAATGGA AGAGTCTGTT GTTCTGTGGA TTTTGAGTGT 2520 CTTCAAAATA ATTGAAGTAT TTACAGTGGA CTCAACGCAG AAGAATGGAC GAAATGACCA 2580 TCCAACGTGA TTAAGGATAG GAATCGGTAG TTTGGTTTTT TTGTTTGTTT TGTTTTTTTA 2640 ACCACAGATA ATTGCCAAAG TTTCCACCTG AGGACGGTGT TTCGGAGGTT GCCTTTTGGA 2700 CCTACCACTT TGCTCATTCT TGCTAACCTA GTCTAGGTGA CCTACAGTGC CGTGCATTTA 2760 AGTCAATGGT TGTTAAAAGA AGTTTCCCGT GTTGTAAATC ATGTTTCCCT TATCAGATCA 2820 TTTGCAAATA CATTTAAATG ATCTCATGGT AAATGGTTGA TGTATTTTTT GGGTTTATTT 2880 TGTGTACTAA CCATAATAGA GAGAGACTCA GCTCCTTTTA TTTATTTTGT TGATTTATGG 2940 ATCAAATTCT AAAATAAAGT TGCCTGTTGT GACTTTT 2977 Seq ID NO : 194 DNA Sequence Nucleic Acid Accession # : NM_016180. 1 Coding sequence : 26.. 1618 1 11 21 31 41 51 ( CAGGAAGGTT CCTCTCCCAG TGGCCATGGG TAGCAACAGT GGGCAGGCTG GCCGCCACAT 60 CTATAAATCC CTAGCTGATG ATGGCCCCTT TGACTCTGTG GAGCCGCCTA AAAGACCCAC 120 CAGCAGACTC ATCATGCACA GCATGGCCAT GTTCGGAAGA GAGTTCTGCT ACGCGGTGGA 180 GGCAGCGTAT GTGACCCCAG TCCTGCTCAG CGTAGGTCTG CCCAGCAGCC TGTACAGCAT 240 TGTGTGGTTC CTCAGCCCCA TCCTGGGATT CCTGCTGCAG CCCGTGGTCG GATCGGCCAG 300 CGACCACTGC CGGTCCAGGT GGGGCCGCCG GAGACCCTAC ATCCTCACCC TGGGAGTCAT 360 GATGCTCGTG GGCATGGCTC TGTACCTCAA TGGGGCTACT GTTGTAGCAG CTTTGATTGC 420 TAACCCAAGG AGGAAGCTGG TTTGGGCCAT AAGTGTCACC ATGATAGGTG TCGTTCTCTT 480 TGATTTTGCT GCCGACTTCA TTGATGGGCC CATCAAAGCC TACTTATTTG ATGTCTGCTC 540 CCATCAGGAC AAGGAGAAGG GCCTCCACTA CCATGCCCTC TTCACAGGTT TTGGAGGTGC 600 CCTGGGTTAC CTTTTGGGTG CTATAGACTG GGCCCATCTG GAGCTGGGAA GACTGTTGGG 660

TACAGAATTC CAGGTCATGT TCTTCTTCTC TGCATTGGTG CTCACTTTGT GTTTTACTGT 720 TCATCTGTGC AGTATCTCTG AAGCCCCACT TACAGAGGTT GCAAAGGGCA TTCCCCCACA 780 GCAAACCCCT CAGGACCCTC CATTGTCATC AGATGGAATG TACGAGTATG GTTCTATCGA 840 GAAAGTTAAA AATGGTTACG TAAATCCAGA GCTGGCAATG CAGGGAGCAA AAAACAAAAA 900 TCATGCTGAA CAGACTCGCA GGGCAATGAC ATTAAAGTCA CTGCTGAGAG CACTGGTGAA 960 CATGCCTCCT CACTACCGCT ACCTTTGCAT CAGCCACCTC ATTGGATGGA CGGCCTTCCT 1020 GTCCAACATG CTGTTCTTCA CAGATTTCAT GGGCCAGATT GTGTACCGCG GGGATCCCTA 1080 TAGTGCACAC AACTCCACAG AGTTTCTCAT CTACGAAAGA GGAGTCGAGG TTGGATGTTG 1140 GGGCTTCTGC ATCAACTCCG TGTTTTCCTC ACTTTATTCT TACTTTCAGA AAGTTTTGGT 1200 ATCCTACATT GGATTAAAGG GTCTTTACTT CACGGGATAT TTGCTGTTTG GCCTGGGGAC 1260 GGGATTTATT GGGCTCTTCC CGAATGTCTA CTCCACCCTG GTCCTGTGCA GCCTGTTTGG 1320 TGTAATGTCC AGCACCCTGT ACACTGTGCC CTTTAACCTC ATTACTGAGT ACCACCGCGA 1380 GGAAGAAAAG GAGAGGCAGC AGGCCCCAGG AGGGGACCCA GACAACAGCG TGAGAGGGAA 1440 GGGCATGGAC TGCGCCACCC TCACATGCAT GGTGCAGCTG GCTCAGATCC TGGTCGGAGG 1500 TGGCCTGGGC TTTCTGGTCA ACACAGCCGG GACCGTTGTC GTCGTGGTGA TCACAGCGTC 1560 TGCGGTGGCA CTGATAGGCT GTTGCTTTGT CGCTCTCTTT GTTAGATATG TGGATTAGGT 1620 CAATAAAGAG ACAATGACCC TAAAAAAAAA 1650 Seq ID NO : 195 DNA Sequence Nucleic Acid Accession # : Nom 012400. 2 Coding sequence : 18.. 455 1 11 21 31 41 51 TGCTCTGTGC TGGGATCATG GAACTTGCAC TGCTGTGTGG GCTGGTGGTG ATGGCTGGTG 60 TGATTCCAAT CCAGGGCGGG ATCCTGAACC TGAACAAGAT GGTCAAGCAA GTGACTGGGA 120 AAATGCCCAT CCTCTCCTAC TGGCCCTACG GCTGTCACTG CGGACTAGGT GGCAGAGGCC 180 AACCCAAAGA TGCCACGGAC TGGTGCTGCC AGACCCATGA CTGCTGCTAT GACCACCTGA 240 AGACCCAGGG GTGCAGCATC TACAAGGACT ATTACAGATA CAACTTTTCC CAGGGGAACA 300 TCCACTGCTC TGACAAGGGA AGCTGGTGTG AGCAGCAGCT GTGTGCCTGT GACAAGGAGG 360 TGGCCTTCTG CCTGAAGCGC AACCTGGACA CCTACCAGAA GCGACTGCGT TTCTACTGGC 420 GGCCCCACTG CCGGGGGCAG ACCCCTGGGT GCTAGAAGCC CACACCCTCT ACCCTGTTCC 480 TCAGCATGGA GCTCTGGCAT CCCCACCTCA GTATCTAACC TGAACCAGCC TGGCTTTTCA 540 AACACTCCGG GGGGAGGTAG TCCCAGCCTC CCCCGGAACC CTCTACCAAT GCCTTCTGAC 600 CTTCTGAAGC TTTCCGAATC CTCCCAGTTG AGGCAGTAGC TGTGTCCTCT GAGGGTGGAT 660 GGGAATCTTG GGAGAAGCCC AAGCAAGGGA GCCCTCAGAG GTGGTGTTTG GACCAAAGCA 720 TCGGGGTGGG GGAGGGGTCT GCCGCTGTCC CCCACCTGCT GGCCCCCTTG TCCTTCCTCA 780 CCCCCTCCAA TATAGTCTCG GAGCTACAAC CGCAGCAGCC ACTATAAAGG GCAATATTGA 840 TCTTTCTGTC CATGTGGCTC TATCTTTTAA AACCTCAAGG CCCTCCACTG TCCTAAGATA 900 AAGCCTCTCA TAGGCACTGG GGACCCTGCA CAGTCTGGCC ATGTGACCCT CTCCCCAGGC 960 AAGCTCTGAA GTCCCTGCAG GTGGAGGCCA TGCCTGTCTT AAACTCAGTT GCATCCCTGG 1020 TGCCCAAAGC AACACCAGAA CCAAGAAGGA GCTCCATAAA TCCTTCTTGG GTGAAGCCTA 1080 GACAAAGCCG CCAGGTCTTG TGGCTCCAGG CACCAGAGCC TTGAGTACTT TCTCCTGCCT 1140 CCAGGCATTG GCTCAGGGTG AATTACAAGG GGCTACTGAA TGGCTATTAC TTTCATCACG 1200 ACTGATCCCC ACCTCCTCAG GGTCAAAGGG CTACTTTCTG GAAGTCTCCC CAGGCTGACT 1260 CCTTCTCCCT GACTGCAAGG GCTCACTCCC TCCTCCAAGC TCCCACAATG CTTCATGGCT 1320 CTGCCGCTTA CCTAGCTTGG CCTAGAGTGG CAAATGGAAC TTCTCTGATC TCCCCCAACT 1380 AGACTGGAGC CCCCGAAGGA TGGAGACCAT GTCTGTGCCA TCTCTGTTTC CCCTGTTTTC 1440 CCACATACTA GGTGCTCAAT TCATGCCTGT GAATGGCGTG AGCCCATAAT GGATACACAG 1500 AGGTTGCAGC AGATGGTGTG GGTACCTCAC CCAGATATCA TCCAGGCCCA AGGCCCCTCT 1560 CCCTGAGTGA GGCCAGGTGT TGGCAGCCAA CTGCTCCAAT CTGCCTCCTT CCCCTAAATA 1620 CTGCCCTGGT CTAGTGGGAG CTGCCTTCCC CCTGCCCCAC CTCTCCCACC AAGAGGCCAC 1680 CTGTCACTCA TGGCCAGGAG AGTGACACCA TGGAGGGTAC AATTGCCAGC TCCCCCGTGT 1740 CTGTGCAGGA TTGTCTGGGT TGAATGACAC TCTCAAATTG TTCCTGGGAT CGGGCTGAGG 1800 CCAGGCCTCT CCTGGAACCA CCTCTCTGCT TGGTCTGACC CCTTGGCCTA TCCAGTTTTC 1860 CTGGTTCCCT CACAGGTTTC TCCAGAAAGT ACTCCCTCAG TAAAGCATTT GCACAAGAAT 1920 CCTTGTCTCA GGCTCTGCTT CTAAGGAAAG AGACTGAAGA GGGACAACTT TTTCCTATGA 1980 GGACTCCCAA TCTGCCATTT GTGTGTGGCT AGCTGTTTCC AGCCAGGGGG CTGAGGCACC 2040 TGCAGTCACC CACACTCTGG GCCTGTGGCA CCATCTGTGC CTCAGCTGAC TGAGCAGTTC 2100 TGAGATGTGG TGACTCATGT GAAGTGGTGT CATAGGAATG AAGGACTGTG GGCGCTGGGT 2160 TCAAATTCCA GTTCTATGCA CCACTCCAGG TAGGGATACC CATGGGGGCA GCTGTGCCTG 2220 TGTGGGGGAA CAGGGTAGGG AAATCTCCAT ACCTTCTCAA TTTTGCTGTG AACCTAAAAC 2280 TGCCATATAA AGATAAAGTC TAGGCCAGGC ATGGTGGCTC ATGCCTGTAA TCCCAACACT 2340 TAGGGTGGCT GAGGCAGGCA GATCACCTGG GGTCAGGAGT TCAAGACCAG CCTGCCCAAC 2400 ATGGCAAAAC CTCGTCTCTA CTAAAAATAC AAAAATTAGC CAGGCATCGT GGTGGGTGCC 2460 TGTAATCCCA GCTATTCAGG AGGCTGAGGC AGGAGAATCA CTTGGACCTG GGAGGCAGAG 2520 GTTTCAGTGA GCCCAGATCG CGACACTGCA CTCCAGCCTG GGCAACAGAG TGACACTCTG 2580 TCTCAAAAAA TAAAATAAAA TAAAATAAAA TAAAATAAAA TAAAATAAAA AAAAAAAAAA 2640 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 2700 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA 2747 Seq ID NO : 196 DNA Sequence Nucleic Acid Accession # : Nom 018833. 1 Coding sequence : 80.. 2041 1 11 21 31 41 51 GAGGTTGGGA GAGACGGAGC GGACCTCAGC GCTGAAGCAG AAGTCCCCGG AGCTGCGGTC 60 TCCCCGCCGC GGCTGAGCCA TGCGGCTCCC TGACCTGAGA CCCTGGACCT CCCTGCTGCT 120 GGTGGACGCG GCTTTACTGT GGCTGCTTCA GGGCCCTCTG GGGACTTTGC TTCCTCAAGG 180 GCTGCCAGGA CTATGGCTGG AGGGGACCCT GCGGCTGGGA GGGCTGTGGG GGCTGCTAAA 240 GCTAAGAGGG CTGCTGGGAT TTGTGGGGAC ACTGCTGCTC CCGCTCTGTC TGGCCACCCC 300 CCTGACTGTC TCCCTGAGAG CCCTGGTCGC GGGGGCCTCA CGTGCTCCCC CAGCCAGAGT 360 CGCTTCAGCC CCTTGGAGCT GGCTGCTGGT GGGGTACGGG GCTGCGGGGC TCAGCTGGTC 420 ACTGTGGGCT GTTCTGAGCC CTCCTGGAGC CCAGGAGAAG GAGCAGGACC AGGTGAACAA 480 CAAAGTCTTG ATGTGGAGGC TGCTGAAGCT CTCCAGGCCG GACCTGCCTC TCCTCGTTGC 540

CGCCTTCTTC TTCCTTGTCC TTGCTGTTTT GGGTGAGACA TTAATCCCTC ACTATTCTGG 600 TCGTGTCATT GACATCCTGG GAGGTGATTT TGACCCCCAT GCCTTTGCCA GTGCCATCTT 660 CTTCATGTGC CTCTTCTCCT TTGGCAGCTC ACTGTCTGCA GGCTGCCGAG GAGGCTGCTT 720 CACCTACACC ATGTCTCGAA TCAACTTGCG GATCCGGGAG CAGCTTTTCT CCTCCCTGCT 780 GCGCCAGGAC CTCGGTTTCT TCCAGGAGAC TAAGACAGGG GAGCTGAACT CACGGCTGAG 840 CTCGGATACC ACCCTGATGA GTAACTGGCT TCCTTTAAAT GCCAATGTGC TCTTGCGAAG 900 CCTGGTGAAA GTGGTGGGGC TGTATGGCTT CATGCTCAGC ATATCGCCTC GACTCACCCT 960 CCTTTCTCTG CTGCACATGC CCTTCACAAT AGCAGCGGAG AAGGTGTACA ACACCCGCCA 1020 TCAGGAAGTG CTTCGGGAGA TCCAGGATGC AGTGGCCAGG GCGGGGCAGG TGGTGCGGGA 1080 AGCCGTTGGA GGGCTGCAGA CCGTTCGCAG TTTTGGGGCC GAGGAGCATG AAGTCTGTCG 1140 CTATAAAGAG GCCCTTGAAC AATGTCGGCA GCTGTATTGG CGGAGAGACC TGGAACGCGC 1200 CTTGTACCTG CTCATAAGGA GGGTGCTGCA CTTGGGTGTG CAGATGCTGA TGCTGAGCTG 1260 TGGGCTGCAG CAGATGCAGG ATGGGGAGCT CACCCAGGGC AGCCTGCTTT CCTTTATGAT 1320 CTACCAGGAG AGCGTGGGGA GCTATGTGCA GACCCTGGTA TACATATATG GGGATATGCT 1380 CAGCAACGTG GGAGCTGCAG AGAAGGTTTT CTCCTACATG GACCGACAGC CAAATCTGCC 1440 TTCACCTGGC ACGCTTGCCC CCACCACTCT GCAGGGGGTT GTGAAATTCC AAGACGTCTC 1500 CTTTGCATAT CCCAATCGCC CTGACAGGCC TGTGCTCAAG GGGCTGACGT TTACCCTACG 1560 TCCTGGTGAG GTGACGGCGC TGGTGGGACC CAATGGGTCT GGGAAGAGCA CAGTGGCTGC 1620 CCTGCTGCAG AATCTGTACC AGCCCACAGG GGGACAGGTG CTGCTGGATG AAAAGCCCAT 1680 CTCACAGTAT GAACACTGCT ACCTGCACAG CCAGGTGGTT TCAGTTGGGC AGGAGCCTGT 1740 GCTGTTCTCC GGTTCTGTGA GGAACAACAT TGCTTATGGG CTGCAGAGCT GCGAAGATGA 1800 TAAGGTGATG GCGGCTGCCC AGGCTGCCCA CGCAGATGAC TTCATCCAGG AAATGGAGCA 1860 TGGAATATAC ACAGATGTAG GGGAGAAGGG AAGCCAGCTG GCTGCGGGAC AGAAACAACG 1920 TCTGGCCATT GCCCGGGCCC TTGTACGAGA CCCGCGGGTC CTCATCCTGG ATGAGGCTAC 1980 TAGTGCCCTA GATGTGCAGT GCGAGCAGGC CAAAACCCTT TGGAAGTTCA TGATATTTTG 2040 AATTTCAATG GATATTTCCT GGGAATAATG AGTTCAAATG AACGAATATG TGGAACAAAG 2100 CATCACCAAC ATTTATTTTT TCAGGATGAG GTGATGGACA AAACCATCAC AGGGAAATTG 2160 AGGCAAATAG TACATGTAAA ACAATACTTC GGGTGAGTCC ACCTATCCCA AAGTCGTATC 2220 AAAGAAGTGG CTGCAGATTG GAGCCCAAAG CCTTTGGTTC CTCAGTTTCC AAATGGATTC 2280 TCACTAGGTG GGATCATGAG TTTGCTTTGG ACACCCCAAA TTCTAACTAT TTCTTTTGTT 2340 TCTTACATCC TTTCCCTCTT CCCCAGCCCC TTCCCCTCAT GTTACACCTC TTGCTGGTTT 2400 GAGACGTCAA TCACCACTGA GAAAGAATTA AACCAGTATT TTGAGCTGGC AAAATTCTTA 2460 GCCTAGTACA ATTCCTTCAA TTAAACTGTA GCTCAAC 2497 Seq ID NO : 197 DNA Sequence Nucleic Acid Accession # : NM002416 Coding sequence : 40-417 1 11 21 31 41 51 ATCCAATACA GGAGTGACTT GGAACTCCAT TCTATCACTA TGAAGAAAAG TGGTGTTCTT 60 TTCCTCTTGG GCATCATCTT GCTGGTTCTG ATTGGAGTGC AAGGAACCCC AGTAGTGAGA 120 AAGGGTCGCT GTTCCTGCAT CAGCACCAAC CAAGGGACTA TCCACCTACA ATCCTTGAAA 180 GACCTTAAAC AATTTGCCCC AAGCCCTTCC TGCGAGAAAA TTGAAATCAT TGCTACACTG 240 AAGAATGGAG TTCAAACATG TCTAAACCCA GATTCAGCAG ATGTGAAGGA ACTGATTAAA 300 AAGTGGGAGA AACAGGTCAG CCAAAAGAAA AAGCAAAAGA ATGGGAAAAA ACATCAAAAA 360 AAGAAAGTTC TGAAAGTTCG AAAATCTCAA CGTTCTCGTC AAAAGAAGAC TACATAAGAG 420 ACCACTTCAC CAATAAGTAT TCTGTGTTAA AAATGTTCTA TTTTAATTAT ACCGCTATCA 480 TTCCAAAGGA GGATGGCATA TAATACAAAG GCTTATTAAT TTGACTAGAA AATTTAAAAC 540 ATTACTCTGA AATTGTAACT AAAGTTAGAA AGTTGATTTT AAGAATCCAA ACGTTAAGAA 600 TTGTTAAAGG CTATGATTGT CTTTGTTCTT CTACCACCCA CCAGTTGAAT TTCATCATGC 660 TTAAGGCCAT GATTTTAGCA ATACCCATGT CTACACAGAT GTTCACCCAA CCACATCCCA 720 CTCACAACAG CTGCCTGGAA GAGCAGCCCT AGGCTTCCAC GTACTGCAGC CTCCAGAGAG 780 TATCTGAGGC ACATGTCAGC AAGTCCTAAG CCTGTTAGCA TGCTGGTGAG CCAAGCAGTT 840 TGAAATTGAG CTGGACCTCA CCAAGCTGCT GTGGCCATCA ACCTCTGTAT TTGAATCAGC 900 CTACAGGCCT CACACACAAT GTGTCTGAGA GATTCATGCT GATTGTTATT GGGTATCACC 960 ACTGGAGATC ACCAGTGTGT GGCTTTCAGA GCCTCCTTTC TGGCTTTGGA AGCCATGTGA 1020 TTCCATCTTG CCCGCTCAGG CTGACCACTT TATTTCTTTT TGTTCCCCTT TGCTTCATTC 1080 AAGTCAGCTC TTCTCCATCC TACCACAATG CAGTGCCTTT CTTCTCTCCA GTGCACCTGT 1140 CATATGCTCT GATTTATCTG AGTCAACTCC TTTCTCATCT TGTCCCCAAC ACCCCACAGA 1200 AGTGCTTTCT TCTCCCAATT CATCCTCACT CAGTCCAGCT TAGTTCAAGT CCTGCCTCTT 1260 AAATAAACCT TTTTGGACAC ACAAATTATC TTAAAACTCC TGTTTCACTT GGTTCAGTAC 1320 CACATGGGTG AACACTCAAT GGTTAACTAA TTCTTGGGTG TTTATCCTAT CTCTCCAACC 1380 AGATTGTCAG CTCCTTGAGG GCAAGAGCCA CAGTATATTT CCCTGTTTCT TCCACAGTGC 1440 CTAATAATAC TGTGGAACTA GGTTTTAATA ATTTTTTAAT TGATGTTGTT ATGGGCAGGA 1500 TGGCAACCAG ACCATTGTCT CAGAGCAGGT GCTGGCTCTT TCCTGGCTAC TCCATGTTGG 1560 CTAGCCTCTG GTAACCTCTT ACTTATTATC TTCAGGACAC TCACTACAGG GACCAGGGAT 1620 GATGCAACAT CCTTGTCTTT TTATGACAGG ATGTTTGCTC AGCTTCTCCA ACAATAAGAA 1680 GCACGTGGTA AAACACTTGC GGATATTCTG GACTGTTTTT AAAAAATATA CAGTTTACCG 1740 AAAATCATAT AATCTTACAA TGAAAAGGAC TTTATAGATC AGCCAGTGAC CAACCTTTTC 1800 CCAACCATAC AAAAATTCCT TTTCCCGAAG GAAAAGGGCT TTCTCAATAA GCCTCAGCTT 1860 TCTAAGATCT AACAAGATAG CCACCGAGAT CCTTATCGAA ACTCATTTTA GGCAAATATG 1920 AGTTTTATTG TCCGTTTACT TGTTTCAGAG TTTGTATTGT GATTATCAAT TACCACACCA 1980 TCTCCCATGA AGAAAGGGAA CGGTGAAGTA CTAAGCGCTA GAGGAAGCAG CCAAGTCGGT 2040 TAGTGGAAGC ATGATTGGTG CCCAGTTAGC CTCTGCAGGA TGTGGAAACC TCCTTCCAGG 2100 GGAGGTTCAG TGAATTGTGT AGGAGAGGTT GTCTGTGGCC AGAATTTAAA CCTATACTCA 2160 CTTTCCCAAA TTGAATCACT GCTCACACTG CTGATGATTT AGAGTGCTGT CCGGTGGAGA 2220 TCCCACCCGA ACGTCTTATC TAATCATGAA ACTCCCTAGT TCCTTCATGT AACTTCCCTG 2280 AAAAATCTAA GTGTTTCATA AATTTGAGAG TCTGTGACCC ACTTACCTTG CATCTCACAG 2340 GTAGACAGTA TATAACTAAC AACCAAAGAC TACATATTGT CACTGACACA CACGTTATAA 2400 TCATTTATCA TATATATACA TACATGCATA CACTCTCAAA GCAAATAATT TTTCACTTCA 2460 AAACAGTATT GACTTGTATA CCTTGTAATT TGAAATATTT TCTTTGTTAA AATAGAATGG 2520 TATCAATAAA TAGACCATTA ATCAG Seq ID NO : 198 DNA Sequence

Nucleic Acid Accession # : Nom 006533. 1 Coding sequence : 72.. 467 1 11 21 31 41 51 AGGGAGAGAG GGAGGGGAGG AAATTGGAGA CCCCAGCACC CCCTTGCTCA CTCTCTTGCT 60 CACAGTCCAC GATGGCCCGG TCCCTGGTGT GCCTTGGTGT CATCATCTTG CTGTCTGCCT 120 TCTCCGGACC TGGTGTCAGG GGTGGTCCTA TGCCCAAGCT GGCTGACCGG AAGCTGTGTG 180 CGGACCAGGA GTGCAGCCAC CCTATCTCCA TGGCTGTGGC CCTTCAGGAC TACATGGCCC 240 CCGACTGCCG ATTCCTGACC ATTCACCGGG GCCAAGTGGT GTATGTCTTC TCCAAGCTGA 300 AGGGCCGTGG GCGGCTCTTC TGGGGAGGCA GCGTTCAGGG AGATTACTAT GGAGATCTGG 360 CTGCTCGCCT GGGCTATTTC CCCAGTAGCA TTGTCCGAGA GGACCAGACC CTGAAACCTG 420 GCAAAGTCGA TGTGAAGACA GACAAATGGG ATTTCTACTG CCAGTGAGCT CAGCCTACCG 480 CTGGCCCTGC CGTTTCCCCT CCTTGGGTTT ATGCAAATAC AATCAGCCCA GTGCAAAC 538 Seq ID NO : 199 Protein sequence Protein Accession # : NP 002412. 1 1 11 21 31 41 51 MHSFPPLLLL LFWGWSHSF PATLETQEQD VDLVQKYLEK YYNLKNDGRQ VEKRRNSGPV 60 VEKLKQMQEF FGLKVTGKPD AETLKVMKQP RCGVPDVAQF VLTEGNPRWE QTHLTYRIEN 120 YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN 180 LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHEL GHSLGLSHST DIGALMYPSY 240 TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS KLTFDAITTI RGEVMFFKDR 300 FYMRTNPFYP EVELNFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYWA VQGQNVLHGY 360 PKDIYSSFGF PRTVKHIDAA LSEENTGKTY FFVANKYWRY DEYKRSMDPG YPKMIAHDFP 420 GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN Seq ID NO : 200 Protein sequence Protein Accession # : NP 002412. 1 1 11 21 31 41 51 MHSFPPLLLL LFWGWSHSF PATLETQEQD VDLVQKYLEK YYNLKNDGRQ VEKRRNSGPV 60 VEKLKQMQEF FGLKVTGKPD AETLKVMKQP RCGVPDVAQF VLTEGNPRWE QTHLTYRIEN 120 YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN 180 LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHAL GHSLGLSHST DIGALMYPSY 240 TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS KLTFDAITTI RGEVMFFKDR 300 FYMRTNPFYP EVELNFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYWA VQGQNVLHGY 360 PKDIYSSFGF PRTVKHIDAA LSEENTGKTY FFVANKYWRY DEYKRSMDPG YPKMIAHDFP 420 GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN Seq ID NO : 201 Protein sequence Protein Accession # : NP 002413 1 11 21 31 41 51 MKSLPILLLL CVAVCSAYPL DGAARGEDTS MNLVQKYLEN YYDLEKDVKQ FVRRKDSGPV 60 VKKIREMQKF LGLEVTGKLD SDTLEVMRKP RCGVPDVGHF RTFPGIPKWR KTHLTYRIVN 120 YTPDLPKDAV DSAVEKALKV WEEVTPLTFS RLYEGEADIM ISFAVREHGD FYPFDGPGNV 180 LAHAYAPGPG INGDAHFDDD EQWTKDTTGT NLFLVAAHEI GHSLGLFHSA NTEALMYPLY 240 HSLTDLTRFR LSQDDINGIQ SLYGPPPDSP ETPLVPTEPV PPEPGTPANC DPALSFDAVS 300 TLRGEILIFK DRHFWRKSLR KLEPELHLIS SFWPSLPSGV DAAYEVTSKD LVFIFKGNQF 360 WAIRGNEVRA GYPRGIHTLG FPPTVRKIDA AISDKEKNKT YFFVEDKYWR FDEKRNSMEP 420 GFPKQIAEDF PGIDSKIDAV FEEFGFFYFF TGSSQLEFDP NAKKVTHTLK SNSWLNC Seq ID NO : 202 Protein Sequence Protein Accession # : NP 001845 1 11 21 31 41 51 MEPWSSRWKT KRWLWDFTVT TLALTFLFQA REVRGAAPVD VLKALDFHNS PEGISKTTGF 60 CTNRKNSKGS DTAYRVSKQA QLSAPTKQLF PGGTFPEDFS ILFTVKPKKG IQSFLLSIYN 120 EHGIQQIGVE VGRSPVFLFE DHTGKPAPED YPLFRTVNIA DGKWHRVAIS VEKKTVTMIV 180 DCKKKTTKPL DRSERAIVDT NGITVFGTRI LDEEVFEGDI QQFLITGDPK AAYDYCEHYS 240 PDCDSSAPKA AQAQEPQIDE YAPEDIIEYD YEYGEAEYKE AESVTEGPTV TEETIAQTEA 300 NIVDDFQEYN YGTMESYQTE APRHVSGTNE PNPVEEIFTE EYLTGEDYDS QRKNSEDTLY 360 ENKEIDGRDS DLLVDGDLGE YDFYEYKEYE DKPTSPPNEE FGPGVPAETD ITETSINGHG 420 AYGEKGQKGE PAWEPGMLV EGPPGPAGPA GIMGPPGLQG PTGPPGDPGD RGPPGRPGLP 480 GADGLPGPPG TMLMLPFRYG GDGSKGPTIS AQEAQAQAIL QQARIALRGP PGPMGLTGRP 540 GPVGGPGSSG AKGESGDPGP QGPRGVQGPP GPTGKPGKRG RPGADGGRGM PGEPGAKGDR 600 GFDGLPGLPG DKGHRGERGP QGPPGPPGDD GMRGEDGEIG PRGLPGEAGP RGLLGPRGTP 660 GAPGQPGMAG VDGPPGPKGN MGPQGEPGPP GQQGNPGPQG LPGPQGPIGP PGEKGPQGKP 720 GLAGLPGADG PPGHPGKEGQ SGEKGALGPP GPQGPIGXPG PRGVKGADGV RGLKGSKGEK 780 GEDGFPGFKG DMGLKGDRGE VGQIGPRGXD GPEGPKGRAG PTGDPGPSGQ AGEKGKLGVP 840 GLPGYPGRQG PKGSTGFPGF PGANGEKGAR GVAGKPGPRG QRGPTGPRGS RGARGPTGKP 900 GPKGTSGGDG PPGPPGERGP QGPQGPVGFP GPKGPPGPPG RMGCPGHPGQ RGETGFQGKT 960 GPPGPGGWG PQGPTGETGP IGERGYPGPP GPPGEQGLPG AAGKEGAKGD PGPQGISGKD 1020 GPAGLRGFPG ERGLPGAOGA PGLKGGEGPQ GPPGPVGSPG ERGSAGTAGP IGLRGRPGPQ 1080 GPPGPAGEKG APGEKGPQGP AGRDGVQGPV GLPGPAGPAG SPGEDGDKGE IGEPGQKGSK 1140 GGKGENGPPG PPGLQGPVGA PGIAGGDGEP GPRGQQGMFG QKGDEGARGF PGPPGPIGLQ 1200 GLPGPPGEKG ENGDVGPWGP PGPPGPRGPQ GPNGADGPQG PPGSVGSVGG VGEKGEPGEA 1260 GNPGPPGEAG VGGPKGERGE KGEAGPPGAA GPPGAKGPPG DDGPKGNPGP VGFPGDPGPP 1320 GELGPAGQDG VGGDKGEDGD PGQPGPPGPS GEAGPPGPPG KRGPPGAAGA EGRQGEKGAK 1380 GEAGAEGPPG KTGPVGPQGP AGKPGPEGLR GIPGPVGEQG LPGAAGQDGP PGPMGPPGLP 1440 GLKGDPGSKG EKGHPGLIGL IGPPGEQGEK GDRGLPGTQG SPGAKGDGGI PGPAGPLGPP 1500 GPPGLPGPQG PKGNKGSTGP AGQKGDSGLP GPPGPPGPPG EVIQPLPILS SKKTRRHTEG 1560 MQADADDNIL DYSDGMEEIF GSLNSLKQDI EHMKFPMGTQ TNPARTCKDL QLSHPDFPDG 1620

EYWIDPNQGC SGDSFKVYCN FTSGGETCIY PDKKSEGVRI SSWPKEKPGS WFSEFKRGKL 1680 LSYLDVEGNS INMVQMTFLK LLTASARQNF TYHCHQSAAW YDVSSGSYDK ALRFLGSNDE 1740 EMSYDNNPFI KTLYDGCTSR KGYEKTVIEI NTPKIDQVPI VDVMISDFGD QNQKFGFEVG 1800 PVCFLG Seq ID NO : 203 Protein sequence Protein Accession # : XP 057014 1 11 21 31 41 51 MRPQGPAASP QRLRGLLLLL LLQLPAPSSA SEIPKGKQKA QLRQREWDL YNGMCLQGPA 60 GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL 120 GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ 180 GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE 240 LPK Seq ID NO : 204 Protein sequence Protein Accession # : Eos sequence 1 11 21 31 41 51 MPGTKLTRTG APADYRVILK TSQEDELDVP DDISVRVMSS QSVLVSWVDP VLEKQKKWA 60 SRQYTVRYRE KGELARWDYK QIANRRVLIE NLIPDTVYEF AVRISQGERD GKWSTSVFQR 120 TPESAPTTAP ENLNVWPVNG KPTWAASWD ALPETEGKVK VCLLDTGLFS VSSFQPSAKS 180 FQNTFFHTPR LSNHLEQSPS PILETLLLPW WMVCSLGNAI FSKSGPQTGE AWDLTPKPSL 240 SLCQQECSCT QKDFSCLAYL IDIQTKQVNK DPQLEGSVFG PCFLFYFLTF MLDIGGFSFI 300 MCYEDPVSSL TGNSLKSVAA SKADVQQNTE DNGKPEKPEP SSPSPRAPAS SQHPSVPASP 360 QGRNAKDLLL DLKNKILANG GAPRKPQLRA KKAEELDLQS TEITGEEELG SREDSPMSPS 420 DTQDQKRTLR PPSRHGHSW APGRTAVRAR MPALPRREGV DKPGFSLATQ PRPGAPPSAS 480 ASPAHHASTQ GTSHRPSLPA SLNDNDLVDS DEDERAVGSL HPKGAFAQPR PALSPSRQSP 540 SSVLRDRSSV HPGAKPASPA RRTPHSGAAE EDSSASAPPS RLSPPHGGSS RLLPTQPHLS 600 SPLSKGGKDG EDAPATNSNA PSRSTMSSSV SSHLSSRTQV SEGAEASDGE SHGDGDREDG 660 GRQAEATAQT LRARPASGHF HLLRHKPFAA NGRSPSRFSI GRGPRLQPSS SPQSTVPSRA 720 HPRVPSHSDS HPKLSSGIHG DEEDEKPLPA TWNDHVPSS SRQPISRGWE DLRRSPQRGA 780 SLHRKEPIPE NPKSTGADTH PQGKYSSLAS KAQDVQQSTD ADTEGHSPKA QPGSTDRHAS 840 PARPPAARSQ QHPSVPRRMT PGRAPEQQPP PPVATSQHHP GPQSRDAGRS PSQPRLSLTQ 900 AGRPRPTSQG RSHSSSDPYT ASSRGMLPTA LQNQDEDAQG SYDDDSTEVE AQDVRAPAHA 960 ARAKEAAASL PKHQQVESPT GAGAGGDHRS QRGHAASPAR PSRPGGPQSR ARVPSRAAPG 1020 KSEPPSKRPL SSKSQQSVSA EDEEEEDAGF FKGGKEDLLS SSVPKWPSSS TPRGGKDADG 1080 SLAKEEREPA IALAPRGGSL APVKRPLPPP PGSSPRASHV PSRPPPRSAA TVSPVAGTHP 1140 WPRYTTRAPP GHFSTTPMLS LRQRMMHARF RNPLSRQPAR PSYRQGYNGR PNVEGKVLPG 1200 SNGKPNGQRI INGPQGTKWV VDLDRGLVLN AEGRYLQDSH GNPLRIKLGG DGRTIVDLEG 1260 TPWSPDGLP LFGQGRHGTP LANAQDKPIL SLGGKPLVGL EVIKKTTHPP TTTMQPTTTT 1320 TPLPTTTTPR PTTATTMQPT TTTTPLPTTT PRPTTATTRR TTTRRPTTTV RTTTRTTTTT 1380 TPKPTTPIPT CPPGTLERHD DDGNLIMSSN GIPECYAEED EFSGLETDTA VPTEEAYVIY 1440 DEDYEFETSR PPTTTEPSTT ATTPRVIPEE GAISSFPEEE FDLAGRKRFV APYVTYLNKD 1500 PSAPCSLTDA LDHFQVDSLD EIIPNDLKKS DLPPQHAPRN ITWAVEGCH SFVIVDWDKA 1560 TPGDLVTGYL VYSASYEDFI RNKFSTQASS VTHLPIENLK PNTRYYFKVQ AQNPHGYGPI 1620 SPSVSFVTES DNPLLWRPP GGELSGSHSL SNMIPATRTA MDGNM Seq ID NO : 205 Protein Sequence Protein Accession # : NP 055059 1 11 21 31 41 51 ( MDPPAGAARR LLCPALLLLL LLLPPPLLPP PPPPANARLA AAADPPGGPL GHGAERILAV 60 PVRTDAQGRL VSHWSAATS RAGVRARRAA PVRTPSFPGG NEEEPGSHLF YNVTVFGRDL 120 HLRLRPNARL VAPGATMEWQ GEKGTTRVEP LLGSCLYVGD VAGLAEASSV ALSNCDGLAG 180 LIRMEEEEFF IEPLEKGLAA QEAEQGRVHV VYRRPPTSPP LGGPQALDTG ASLDSLDSLS 240 RALGVLEEHA NSSRRRARRH AADDDYNIEV LLGVDDSWQ FHGKEHVQKY LLTLMNIVNE 300 IYHDESLGAH INWLVRIIL LSYGKSMSLI EIGNPSQSLE NVCRWAYLQQ KPDTGHDEYH 360 DHAIFLTRQD FGPSGMQGYA PVTGMCHPVR SCTLNHEDGF SSAFWAHET GHVLGMEHDG 420 QGNRCGDEVR LGSIMAPLVQ AAFHRFHWSR CSQQELSRYL HSYDCLLDDP FAHDWPALPQ 480 LPGLHYSMNE QCRFDFGLGY MMCTAFRTFD PCKQLWCSHP DNPYFCKTKK GPPLDGTMCA 540 PGKHCFKGHC IWLTPDILKR DGSWGAWSPF GSCSRTCGTG VKFRTRQCDN PHPANGGRTC 600 SGLAYDFQLC SRQDCPDSLA DFREEQCRQW DLYFEHGDAQ HHWLPHEHRD AKERCHLYCE 660 SRETGEWSM KRMVHDGTRC SYKDAFSLCV RGDCRKVGCD GVIGSSKQED KCGVCGGDNS 720 HCKWKGTFT RSPKKHGYIK MFEIPAGARH LLIQEVDATS HHLAVKNLET GKFILNEEND 780 VDASSKTFIA MGVEWEYRDE DGRETLQTMG PLHGTITVLV IPVGDTRVSL TYKYMIHEDS 840 LNVDDNNVLE EDSWYEWAL KKWSPCSKPC GGGSQFTKYG CRRRLDHKMV HRGFCAALSK 900 PKAIRRACNP QECSQPVWVT GEWEPCSQTC GRTGMQVRSV RCIQPLHDNT TRSVHAKHCN 960 DARPESRRAC SRELCPGRWR AGPWSQCSVT CGNGTQERPV PCRTADDSFG ICQEERPETA 1020 RTCRLGPCPR NISDPSKKSY WQWLSRPDP DSPIRKISSK GHCQGDKSIF CRMEVLSRYC 1080 SIPGYNKLSC KSCNLYNNLT NVEGRIEPPP GKHNDIDVFM PTLPVPTVAM EVRPSPSTPL 1140 EVPLNASSTN ATEDHPETNA VDEPYKIHGL EDEVQPPNLI PRRPSPYEKT RNQRIQELID 1200 EMRKKEMLGK F 1211 Seq ID NO : 206 Protein sequence Protein Accession # : NP 076927 1 11 21 31 41 51 MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI 60 LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF 120 TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK 180 VTALHHSVYV REGCASGHW TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH 240 LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR 300 LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGG DASPVLNHAA 360

VPLISNKICN HRDVYGGIIS PSMLCAGYLT GGVDSCQGDS GGPLVCQERR LWKLVGATSF 420 GIGCAEVNKP GVYTRVTSFL DWIHEQMERD LKT Seq ID NO : 207 Protein Sequence Protein Accession # : CAC03433. 2 1 11 21 31 41 51 MLSSTDFTFA SWELWRVDH PNEEQQKDVT LRVSGDLHVG GVMLKLVEQI NISQDWSDFA 60 LWWEQKHCWL LKTHWTLDKY GVQADAKLLF TPQHKMLRLR LPNLKMVRLR VSFSAWFKA 120 VSDICKILNI RRSEELSLLK PSGDYFKKKK KKDKNNKEPI IEDILNLESS PTASGSSVSP 180 GLYSKTMTPI YDPINGTPAS STMTWFSDSP LTEQNCSILA FSQPPQSPEA LADMYQPRSL 240 VDKAKLNAGW LDSSRSLMEQ GIQEDEQLLL RFKYYSFFDL NPKYDAVRIN QLYEQARWAI 300 LLEEIDCTEE EMLIFAALQY HISKLSLSAE TQDFAGESEV DEIEAALSNL EVTLEGGKAD 360 SLLEDITDIP KLADNLKLFR PKKLLPKAFK QYWFIFKDTS IAYFKNKELE QGEPLEKLNL 420 RGCEWPDVN VAGRKFGIKL LIPVADGMNE MYLRCDHENQ YAQWMAACML ASKGKTMADS 480 SYQPEVLNIL SFLRMKNRNS ASQVASSLEN MDMNPECFVS PRCAKKHKSK QLAARILEAH 540 QNVAQMPLVE AKLRFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVSYNRL IKIDAATGIP 600 VTTWRFTNIK QWNVNWETRQ WIEFDQNVF TAFTCLSADC KIVHEYIGGY IFLSTRSKDQ 660 NETLDEDLFH KLTGGQD 677 Seq ID NO : 208 Protein Sequence Protein Accession # : NP 114433. 1 1 11 21 31 41 51 MASRSMRLLL LLSCLAKTGV LGDIIMRPSC APGWFYHKSN CYGYFRKLRN WSDAELECQS 60 YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ KRQQWQWIDG AMYLYRSWSG 120 KSMGGNKHCA EMSSNNNFLT WSSNECNKRQ HFLCKYRP 158 Seq ID NO : 209 Protein Sequence Protein Accession # : XP 051860. 2 1 11 21 31 41 51 MGAAGRQDFL FKAMLTISWL TLTCFPGATS TVAAGCPDQS PELQPWNPGH DQDHHVHIGQ 60 GKTLLLTSSA TVYSIHISEG GKLVIKDHDE PIVLRTRHIL IDNGGELHAG SALCPFQGNF 120 TIILYGRADE GIQPDPYYGL KYIGVGKGGA LELHGQKKLS WTFLNKTLHP GGMAEGGYFF 180 ERSWGHRGVI VHVIDPKSGT VIHSDRFDTY RSKKESERLV QYLNAVPDGR ILSVAVNDEG 240 SRNLDDMARK AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVF 300 KLFQTEHGEY FNVSLSSEWV QDVEWTEWFD HDKVSQTKGG EKISDLWKAH PGKICNRPID 360 IQATTMDGVN LSTEWYKKG QDYRFACYDR GRACRSYRVR FLCGKPVRPK LTVTIDTNVN 420 STILNLEDNV QSWKPGDTLV IASTDYSMYQ AEEFQVLPCR SCAPNQVKVA GKPMYLHIGE 480 EIDGVDMRAE VGLLSRNIIV MGEMEDKCYP YRNHICNFFD FDTFGGHIKF ALGFKAAHLE 540 GTELKHMGQQ LVGQYPIHFH LAGDVDERGG YDPPTYIRDL SIHHTFSRCV TVHGSNGLLI 600 KDWGYNSLG HCFFTEDGPE ERNTFDHCLG. LLVKSGTLLP SDRDSKMCKM ITEDSYPGYI 660 PKPRQDCNAV STFWMANPNN NLINCAAAGS EETGFWFIFH HVPTGPSVGM YSPGYSEHIP 720 LGKFYNNRAH SNYRAGMIID NGVKTTEASA KDKRPFLSII SARYSPHQDA DPLKPREPAI 780 IRHFIAYKNQ DHGAWLRGGD VWLDSCRFAD NGIGLTLASG GTFPYDDGSK QEIKNSLFVG 840 ESGNVGTEMM DNRIWGPGGL DHSGRTLPIG QNFPIRGIQL YDGPINIQNC TFRKFVALEG 900 RHTSALAFRL NNAWQSCPHN NVTGIAFEDV PITSRVFFGE PGPWFNQLDM DGDKTSVFHD 960 VDGSVSEYPG SYLTKNDNWL VRHPDCINVP DWRGAICSGC YAQMYIQAYK TSNLRMKIIK 1020 NDFPSHPLYL EGALTRSTHY QQYQPWTLQ KGYTIHWDQT APAELAIWLI NFNKGDWIRV 1080 GLCYPRGTTF SILSDVHNRL LKQTSKTGVF VRTLQMDKVE QSYPGRSHYY WDEDSGLLFL 1140 KLKAQNEREK FAFCSMKGCE RIKIKALIPK NAGVSDCTAT AYPKFTERAV VDVPMPKKLF 1200 GSQLKTKDHF LEVKMESSKQ HFFHLWNDFA YIEVDGKKYP SSEDGIQWW IDGNQGRWS 1260 HTSFRNSILQ GIPWQLFNYV ATIPDNSIVL MASKGRYVSR GPWTRVLEKL GADRGLKLKE 1320 QMAFVGFKGS FRPIWVTLDT EDHKAKIFQV VPIPWKKKK L 1361 Seq ID NO : 210 Protein Sequence Protein Accession # : NP036244. 1 1 11 21 31 41 51 MSQVKSSYSY DAPSDFINFS SLDDEGDTQN IDSWFEEKAN LENKLLGKNG TGGLFQGKTP 60 LRKANLQQAI VTPLKPVDNT YYKEAEKENL VEQSIPSNAC SSLEVEAAIS RKTPAQPQRR 120 SLRLSAQKDL EQKEKHHVKM KAKRCATPVI IDEILPSKKM KVSNNKKKPE EEGSAHQDTA 180 EKNASSPEKA KGRHTVPCMP PAKQKFLKST EEQELEKSMK MQQEWEMRK KNEEFKKLAL 240 AGIGQPVKKS VSQVTKSVDF HFRTDERIKQ HPKNQEEYKE VNFTSELRKH PSSPARVTKG 300 CTIVKPFNLS QGKKRTFDET VSTYVPLAQQ VEDFHKRTPN RYHLRSKKDD INLLPSKSSV 360 TKICRDPQTP VLQTKHRARA VTCKSTAELE AEELEKLQQY KFKARELDPR ILEGGPILPK 420 KPPVKPPTEP IGFDLEIEKR IQERESKKKT EDEHFEFHSR PCPTKILEDV VGVPEKKVLP 480 ITVPKSPAFA LKNRIRMPTK EDEEEDEPW IKAQPVPHYG VPFKPQIPEA RTVEICPFSF 540 DSRDKERQLQ KEKKIKELQK GEVPKFKALP LPHFDTINLP EKKVKNVTQI EPFCLETDRR 600 GALKAQTWKH QLEEELRQQK EAACFKARPN TVISQEPFVP KKEKKSVAEG LSGSLVQEPF 660 QLATEKRAKE RQELEKRMAE VEAQKAQQLE EARLQEEEQK KEELARLRRE LVHKANPIRK 720 YQGLEIKSSD QPLTVPVSPK FSTRFHC 747 Seq ID NO : 211 Protein Sequence Protein Accession # : NP 065169. 1 1 11 21 31 41 51 MSRRKQAKPQ HINSEEDQGE QQPQQQTPEF ADAAPAAPAA GELGAPVNHP GNDEVASEDE 60 ATVKRLRREE THVCEKCCAE FFSISEFLEH KKNCTKNPPV LIMNDSEGPV PSEDFSGAVL 120 SHQPTSPGSK DCHRENGGSS EDMKEKPDAE SWYLKTETA LPPTPQDISY LAKGKVANTN 180 VTLQALRGTK VAVNQRSADA LPAPVPGANS IPWVLEQILC LQQQQLQQIQ LTEQIRIQVN 240 MWASHALHSS GAGADTLKTL GSHMSQQVSA AVALLSQKAG SQGLSLDALK QAKLPHANIP 300 SATSSLSPGL APFTLKPDGT RVLPNVMSRL PSALLPQAPG SVLFQSPFST VALDTSKKGK 360

GKPPNISAVD VKPKDEAALY KHKCKYCSKV FGTDSSLQIH LRSHTGERPF VCSVCGHRFT 420 TKGNLKVHFH RHPQVKANPQ LFAEFQDKVA AGNGIPYALS VPDPIDEPSL SLDSKPVLVT 480 TSVGLPQNLS SGTNPKDLTG GSLPGDLQPG PSPESEGGPT LPGVGPNYMS PRAGGFQGSG 540 TPEPGSETLK LQQLVENIDK ATTDPNECLI CHRVLSCQSS LKMHYRTHTG ERPFQCKICG 600 RAFSTKGNLK THLGVHRTNT SIKTQHSCPI CQKKFTNAVM LQQHIRMHMG GQIPNTPLPE 660 NPCDFTGSEP MTVGENGSTG AICHDDVIES IDVEEVSSQE APSSSSKVPT PLPSIHSASP 720 TLGFAMMASL DAPGKVGPAP FNLQRQGSRE NGSVESDGLT NDSSSLMGDQ EYQSRSPDIL 780 ETTSFQALSP ANSQAESIKS KSPDAGSKAE SSENSRTEME GRSSLPSTFI RAPPTYVKVE 840 VPGTFVGPST LSPGMTPLLA AQPRRQAKQH GCTRCGKNFS SASALQIHER THTGEKPFVC 900 NICGRAFTTK GNLKVHYMTH GANNNSARRG RKLAIENTMA LLGTDGKRVS EIFPKEILAP 960 SVNVDPWWN QYTSMLNGGL AVKTNEISVI QSGGVPTLPV SLGATSWNN ATVSKMDGSQ 1020 SGISADVEKP SATDGVPKHQ FPHFLEENKI AVS 1053 Seq ID NO : 212 Protein Sequence Protein Accession # : NP 005092 1 11 21 31 41 51 1 1 1 1 1 1 MGWDLTVKML AGNEFQVSLS SSMSVSELKA QITQKIGVHA FQQRLAVHPS GVALQDRVPL 60 ASQGLGPGST VLLWDKCDE PLSILVRNNK GRSSTYEVRL TQTVAHLKQQ VSGLEGVQDD 120 LFWLTFEGKP LEDQLPLGEY GLKPLSTVFM NLRLRGGGTE PGGRS 165 Seq ID NO : 213 Protein sequence Protein Accession # : Eos sequence 1 11 21 31 41 51 MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 60 EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 120 ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 180 DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 240 QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL Seq ID NO : 214 Protein sequence Protein Accession # : NP009046. 1 1 11 21 31 41 51 MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 60 EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNXXFGKTGI IDYGIRLNRS 120 ERWDAYCYNP HAKECGGVFT DPKRIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 180 DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 240 QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL Seq ID NO : 215 Protein Sequence Protein Accession # : NP006389. 1 1 11 21 31 41 51 MAPNASCLCV HVRSEEWDLM TFDANPYDSV KKIKEHVRSK TKVPVQDQVL LLGSKILKPR 60 RSLSSYGIDK EKTIHLTLKV VKPSDEELPL FLVESGDEAK RHLLQVRRSS SVAQVKAMIE 120 TKTGIIPETQ IVTCNGKRLE DGKMMADYGI RKGNLLFLAS YCIGG 165 Seq ID NO : 216 Protein Sequence Protein Accession # : NP 002349. 1 1 11 21 31 41 51 MALQLSREQG ITLRGSAEIV AEFFSFGINS ILYQRGIYPS ETFTRVQKYG LTLLVTTDLE 60 LIKYLNNWE QLKDWLYKCS VQKLVWISN IESGEVLERW QFDIECDKTA KDDSAPREKS 120 QKAIQDEIRS VIRQITATVT FLPLLEVSCS FDLLIYTDKD LWPEKWEES GPQFITNSEE 180 VRLRSFTTTI HKVNSMVAYK IPVND 205 Seq ID NO : 217 Protein sequence Protein Accession # : NP 001889. 1 1 11 21 31 41 51 MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF AISEYNKATK 60 DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 120 EIYEVPWENR RSLVKSRCQE S Seq ID NO : 218 Protein sequence Protein Accession # : NP 009162. 1 1 11 21 31 41 51 MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW 60 RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT 120 MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK 180 GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA 240 LCLLLAWLIV GAALFKGIKS SGKWYFTAL FPYWLLILL VRGATLEGAS KGISYYIGAQ 300 SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIW CLTNCLTSVF 360 AGFAIFSILG HMAHISGKEV SQWKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG 420 LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF 480 CAGWGILIAA ILELVGIIWI YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI 540 FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 600 RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE Seq ID NO : 219 Protein sequence Protein Accession # : NP006389. 1

1 11 21 31 41 51 MAPNASCLCV HVRSEEWDLM TFDANPYDSV KKIKEHVRSK TKVPVQDQVL LLGSKILKPR 60 RSLSSYGIDK EKTIHLTLKV VKPSDEELPL FLVESGDEAK RHLLQVRRSS SVAQVKAMIE 120 TKTGIIPETQ IVTCNGKRLE DGKMMADYGI RKGNLLFLAS YCIGG Seq ID NO : 220 Protein sequence Protein Accession « : Xp094741. 1 1 11 21 31 41 51 MKANYSAEER FLLLGFSDWP SLQPVLFALV LLCYLLTLTG NSALVLLAVR DPRLHTPMYY 60 FLCHLALVDA GFTTSWPPL LANLRGPALW LPRSHCTAQL CASLALGSAE CVLLAVMALD 120 RAAAVCRPLR YAGLVSPRLC RTLASASWLS GLTNSVAQTA LLAERPLCAP RLLDHFICEL 180 PALLKLACGG DGDTTENQMF AARWILLLP FAVILASYGA VARAVCCMRF SGGRRRAVGT 240 CGSHLTAVCL FYGSAIYTYL QPAQRYNQAR GKFVSLFYTV VTPALNPLIY TLRNKKVKGA 300 ARRLLRSLGR GQAGQ Seq ID NO : 221 Protein Sequence Protein Accession # NP 061155. 1 1 11 21 31 41 51 MDPFTEKLLE RTRARRENLQ RKMAERPTAA PRSMTHAKRA RQPLSEASNQ QPLSGGEEKS 60 CTKPSPSKKR CSDNTEVEVS NLENKQPVES TSAKSCSPSP VSPQVQPQAA DTISDSVAVP 120 ASLLGMRRGL NSRLEATAAS SVKTRMQKLA EQRRRWDNDD MTDDIPESSL FSPMPSEEKA 180 ASPPKPLLSN ASATPVGRRG RLANLAATIC SWEDDVNHSF AKQNSVQEQP GTACLSKFSS 240 ASGASARINS SSVKQEATFC SQRDGDASLN KALSSSADDA SLVNASISSS VKATSPVKST 300 TSITDAKSCE GQNPELLPKT PISPLKTGVS KPIVKSTLSQ TVPSKGELSR EICLQSQSKD 360 KSTTPGGTGI KPFLERFGER CQEHSKESPA RSTPHRTPII TPNTKAIQER LFKQDTSSST 420 THLAQQLKQE RQKELACLRG RFDKGNIWSA EKGGNSKSKQ LETKQETHCQ STPLKKHQGV 480 SKTQSLPVTE KVTENQIPAK NSSTEPKGFT ECEMTKSSPL KITLFLEEDK SLKVTSDPKV 540 EQKIEVIREI EMSVDDDDIN SSKVINDLFS DVLEEGELDM EKSQEEMDQA LAESSEEQED 600 ALNISSMSLL APLAQTVGW SPESLVSTPR LELKDTSRSD ESPKPGKFQR TRVPRAESGD 660 SLGSEDRDLL YSIDAYRSQR FKETERPSIK QVIVRKEDVT SKLDEKNNAF PCQVNIKQKM 720 QELNNEINMQ QTVIYQASQA LNCCVDEEHG KGSLEEAEAE RLLLIATGKR TLLIDELNKL 780 KNEGPQRKNK ASPQSEFMPS KGSVTLSEIR LPLKADFVCS TVQKPDAANY YYLIILKAGA 840 ENMVATPLAS TSNSLNGDAL TFTTTFTLQD VSNDFEINIE VYSLVQKKDP SGLDKKKKTS 900 KSKAITPKRL LTSITTKSNI HSSVMASPGG LSAVRTSNFA LVGSYTLSLS SVGNTKFVLD 960 KVPFLSSLEG HIYLKIKCQV NSSVEERGFL TIFEDVSGFG AWHRRWCVLS GNCISYWTYP 1020 DDEKRKNPIG RINLANCTSR QIEPANREFC ARRNTFELIT VRPQREDDRE TLVSQCRDTL 1080 CVTKNWLSAD TKEERDLWMQ KLNQVLVDIR LWQPDACYKP IGKP 1124 Seq ID NO : 222 Protein Sequence Protein Accession k : Q9H8V3 1 11 21 31 41 51 MAENSVLTST TGRTSLADSS IFDSKVTEIS KENLLIGSTS YVEEEMPQIE TRVILVQEAG 60 KQEELTKALK DIKVGFVKME SVEEFEGLDS PEFENVFWT DFQDSVFNDL YKADCRVIGP 120 PWLNCSQKG EPLPFSCRPL YCTSMMNLVL CFTGFRKKEE LVRLVTLVHH MGGVIRKDFN 180 SKVTHLVANC TQGEKFRVAV SLGTPIMKPE WIYKAWERRN EQDFYAAVDD FRNEFKVPPF 240 QDCIFSFLGF SDEEKTNMEE MTEMQGGKYL PLGDERCTHL WEENIVKDL PFEPSKKLYV 300 VKQEWFWGSI QMDARAGETM YLYEKANTPE LKKSVSMLSL NTPNSNRKRR RLKETLAQLS 360 RDTDVSPFPP RKRPSAEHSL SIGSLLDISN TPESSINYGD TPKSCTKSSK SSTPVPSKQS 420 ARWQVAKELY QTESNYVNIL ATIIQLFQVP LEEEGQRGGP ILAPEEIKTI FGSIPDIFDV 480 HTKIKDDLED LIVNWDESKS IGDIFLKYSK DLVKTYPPFV NFFEMSKETI IKCEKQKPRF 540 HAFLKINQAK PECGRQSLVE LLIRPVQRLP SVALLLNDLK KHTADENPDK STLEKAIGSL 600 KEVMTHINED KRKTEAQKQI FDWYEVDGC PANLLSSHRS LVQRVETISL GEHPCDRGEQ 660 VTLFLFNDCL EIARKRHKVI GTFRSPHGQT RPPASLKHIH LMPLSQIKKV LDIRETEDCH 720 NAFALLVRPP TEQANVLLSF QMTSDELPKE NWLKMLCRHV ANTICKADAE NLIYTADPES 780 FEVNTKDMDS TLSRASRAIK KTSKKVTRAF SFSKTPKRAL RRALMTSHGS VEGRSPSSND 840 KHVMSRLSST SSLAGIPSPS LVSLPSFFER RSHTLSRSTT HLI 883 Seq ID NO : 223 Protein Sequence Protein Accession # : NP 002488. 1 1 11 21 31 41 51 MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 60 ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 120 TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 180 YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 240 SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 300 PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 360 RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 420 QLRAQALSDI EKNYQLKSRQ ILGMR 445 Seq ID NO : 224 Protein Sequence Protein Accession # : Eos sequence 1 11 21 31 41 51 DISYENENYN SSWIPGSHIV SPSLLLNLNN GQLLPLQLQG PLNSWIPPFS GILQQQQQAQ 60 IPGLSQFSLS ALDQFAGLLP NQIPLTGEAS FAQGAQAGQV DPLQLQTPPQ TQPGPSHVMP 120 YVFSFKMPQE QGQMFQYYPV YMVLPWEQPQ QTVPRSPQQT RQQQYEEQIP FYAQFGYIPQ 180 LAEPAISGGQ QQLAFDPQLG TAPEIAVMST GEEIPYLQKE AINFRHDSAG VFMPSTSPKP 240 STTNVFTSAV DQTITPELPE EKDKTDSLRE P 271

Seq ID NO : 225 Protein Sequence Protein Accession # : eos sequence 1 11 21 31 41 51 1 1 1 1 1 1 RGKEHRSRMV QIFLFRSRSK IYHTKMKIII LLGFLGATLS APLIPQRLMS ASNSNELLLN 60 LNNGQLLPLQ LQGPLNSWIP PFSGILQQQQ QAQIPGLSQF SLSALDQFAG LLPNQIPLTG 120 EASFAQGAQA GQVDPLQLQT PPQTQPGPSH VMPYVFSFKM PQEQGQMFQY YPVYMVLPWE 180 QPQQTVPRSP QQTRQQQYEE QIPFYAQFGY IPQLAEPAIS GGQQQLAFDP QLGTAPEIAV 240 MSTGEEIPYL QKEAINFRHD SAGVFMPSTS PKPSTTNVFT SAVDQTITPE LPEEKDKTDS 300 LREP 304 Seq ID NO : 226 Protein Sequence Protein Accession # : NP 003970. 1 1 11 21 31 41 51 MATTVPDGCR NGLKSKYYRL CDKAEAWGIV LETVATAGW TSVAFMLTLP ILVCKVQDSN 60 RRKMLPTQFL FLLGVLGIFG LTFAFIIGLD GSTGPTRFFL FGILFSICFS CLLAHAVSLT 120 KLVRGRKPLS LLVILGLAVG FSLVQDVIAI EYIVLTMURT NVNVFSELSA PRRNEDFVLL 180 LTYVLFLMAL TFLMSSFTFC GSFTGWKRHG AHIYLTMLLS IAIWVAWITL LMLPDFDRRW 240 DDTILSSALA ANGWVFLLAY VSPEFWLLTK QRNPMDYPVE DAFCKPQLVK KSYGVENRAY 300 SQEEITQGFE ETGDTLYAPY STHFQLQNQP PQKEFSIPRA HAWPSPYKDY EVKKEGS 357 Seq ID NO : 227 Protein Sequence Protein Accession # : NP 116575. 1 1 11 21 31 41 51 ( MPKIVLNGVT VDFPFQPYKC QQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR 60 EHLRDGISAR KIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT 120 QVINELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE 180 KSLEQELASP ILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI 240 DLKGTWIFD EAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS 300 ADSPSPGLNM ELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ 360 TKGCILDSLD QIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS 420 YKVHIHPDAG HRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG 480 TLAPVSSFAL EMQIPFPVCL ENPHIIDKHQ IWVGWPRGP DGAQLSSAFD RRFSEECLSS 540 LGKALGNIAR WPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE 600 TISAYYARVA APGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRWLKM 660 QFLDEMKGQG GAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA 720 RAQLPSWVRP HVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP 780 GPFFSTRKAK SLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH 840 SEQRAGSPGE EQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM 900 VAVKQELSQA NFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH 960 KQQFEEVCIQ LTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE 1020 HLNQGRPHLS PRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL 1080 AALTAYKQDD DLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY 1140 PGMEPPGPQE ERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA 1200 GPSQSSGPPH GPAASEWGEP HGRDIAGQQA TGAPGGPLSA GCVCQGCGAE DWPFQCPAC 1260 DFQRCQACWQ RHLQASRMCP ACHTASRKQS VMQVFWPEPH KDHEGAGGAR PVAAVPGVGA 1320 ACPAAGAGCT RSGRNTHLPL AGRRDRGAAG VCPVPPRHLC AAAVPPRQPH DVWPVSTAPL 1380 HAVLELPGAL PLLQRPLRGA 1400 Seq ID NO : 228 Protein Sequence Protein Accession # : NP 057518. 1 1 11 21 31 41 51 1 1 1 1 1 1 MPKIVLNGVT VDFPFQPYKC QQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR 60 EHLRDGISAR KIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT 120 QVINELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE 180 KSLEQELASP ILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI 240 DLKGTWIFD EAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS 300 ADSPSPGLNM ELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ 360 TKGCILDSLD QIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS 420 YKVHIHPDAG HRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG 480 TLAPVSSFAL EMQIPFPVCL ENPHIIDKHQ IWVGWPRGP DGAQLSSAFD RRFSEECLSS 540 LGKALGNIAR WPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE 600 TISAYYARVA APGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRVVLKM 660 QFLDEMKGQG GAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA 720 RAQLPSWVRP HVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP 780 GPFFSTRKAK SLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH 840 SEQRAGSPGE EQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM 900 VAVKQELSQA NFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH 960 KQQFEEVCIQ LTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE 1020 HLNQGRPHLS PRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL 1080 AALTAYKQDD DLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY 1140 PGMEPPGPQE ERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA 1200 GPSQSSGPPH GPAASEWGL 1219 Seq ID NO : 229 Protein Sequence Protein Accession # : NP056462. 1 1 11 21 31 41 51 MPAPAPRATA PSVRGEDAVS EAKSPGPFFS TRKAKSLDLH VPSLKQRSSG SPAAGDPESS 60 LCVEYEQEPV PARQRPRGLL AALEHSEQRA GSPGEEQAHS CSTLSLLSEK RPAEEPRGGR 120

KKIRLVSHPE EPVAGAQTDR AKLFMVAVKQ ELSQANFATF TQALQDYKGS DDFAALAACL 180 GPLFAEDPKK HNLLQGFYQF VRPHHKQQFE EVCIQLTGRG CGYRPEHSIP RRQRAQPVLD 240 PTGRTAPDPK LTVSTAAAQQ LDPQEHLNQG RPHLSPRPPP TGDPGSQPQW GSGVPRAGKQ 300 GQHAVSAYLA DARRALGSAG CSQLLAALTA YKQDDDLDKV LAVLAALTTA KPEDFPLLHR 360 FSMFVRPHHK QRFSQTCTDL TGRPYPGMEP PGPQEERLAV PPVLTHRAPQ PGPSRSEKTG 420 KTQSKISSFL RQRPAGTVGA GGEDAGPSQS SGPPHGPAAS EWGEPHGRDI AGQQATGAPG 480 GPLSAGCVCQ GCGAEDWPF QCPACDFQRC QACWQRHLQA SRMCPACHTA SRKQSVMQVF 540 WPEPQ 545 Seq ID NO : 230 Protein Sequence Protein Accession # : NP 003814. 1 1 11 21 31 41 51 i I I I I I MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR 60 PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF 120 AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA 180 LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE 240 GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH 300 Seq ID NO : 231 Protein Sequence Protein Accession # : Nu-116563. 1 1 11 21 31 41 51 MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR 60 PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF 120 AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA ISO LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE 240 GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH 300 Seq ID NO : 232 Protein Sequence Protein Accession # NP_000584. 2 1 11 21 31 41 51 MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP GRDRDGVRVP 60 MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 120 GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 180 APGSADSTRL LHWGSHPTAF WSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 240 GSETRRLSLF LVLWLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 300 LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 360 ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 420 AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 480 LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 540 YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 600 GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 660 YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 720 PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 780 REGGTHQQLM EKKGCYWAMV QAPADAPE 808 Seq ID NO : 233 Protein Sequence Protein Accession # : NP002414. 1 1 11 21 31 41 51 MRLTVLCAVC LLPGSLALPL PQEAGGMSEL QWEQAQDYLK RFYLYDSETK NANSLEAKLK 60 EMQKFFGLPI TGMLNSRVIE IMQKPRCGVP DVAEYSLFPN SPKWTSKW T YRIVSYTRDL 120 PHITVDRLVS KALNMWGKEI PLHFRKWWG TADIMIGFAR GAHGDSYPFD GPGNTLAHAF 180 APGTGLGGDA HFDEDERWTD GSSLGINFLY AATHELGHSL GMGHSSDPNA VMYPTYGNGD 240 PQNFKLSQDD IKGIQKLYGK RSNSRKK 267 Seq ID NO : 234 Protein Sequence Protein Accession # : NP 061144 1 11 21 31 41 51 MPIEIVCKIK FAEEDAKPKE KEAGDEQSLL GAVAPGAAPR DLATFASTST LHGLGRACGP 60 GPHGLRRTLW ALALLTSLAA FLYQAAGLAR GYLTRPHLVA MDPAAPAPVA GFPAVTLCNI 120 NRFRHSALSD ADIFHLANLT GLPPKDRDGH RAAGLRYPEP DMVDILNRTG HQLADMLKSC 180 NFSGHHCSAS NFSWYTRYG KCYTFNADPR SSLPSRAGGM GSGLEIMLDI QQEEYLPIWR 240 ETNETSFEAG IRVQIHSQEE PPYIHQLGFG VSPGFQTFVS CQEQRLTYLP QPWGNCRAES 300 ELREPELQGY SAYSVSACRL RCEKEAVLQR CHCRMVHMPG NETICPPNIY IECADHTLDS 360 LGGGPEGPCF CPTPCNLTRY GKEISMVRIP NRGSARYLAR KYNRNETYIR ENFLVLDVFF 420 EALTSEAMEQ RAAYGLSALL GDLGGQMGLF IGASILTLLE ILDYIYEVSW DRLKRVWRRP 480 KTPLRTSTGG ISTLGLQELK EQSPCPSLGR AEGGGVSSLL PNHHHPHGPP GGLFEDFAC 539 Seq ID NO : 235 Protein Sequence Protein Accession # : BAC03567 1 11 21 31 41 51 MEVSSPSPAQ RLRRKKRPMV QGPAGCQVFQ PSPSGGTAGD PGGLSDPFYP PRSGSLALGD 60 PSSDPACSQS GPMEAEEDSL PEQPEDSAQL QQEKPSLYIG VRGTWRSMQ EVLWTRLREL 120 PDPVLSEEW EGIAAGIEAA LWDLTQGTNG RYKTKYRSLL FNLRDPRNLD LFLKWHGDV 180 TPYDLVRMSS MQLAPQELAR WRDQEEKRGL NIIEQQQKEP CRLPASKMTH KGEVEIQRDM 240 DQTLTLEDLV GPQMFMDCSP QALPIASEDT TGQHDHHFLD PNCHICKDWE PSNELLGSFE 300 AAKSCGDNIF QKALSQTPMP APEMPKTREL SPTEPQDRVP PSGLHVPAAP TKALPCLPPW 360 EGVLDMFSIK RFRARAQLVS GHSCRLVQAL PTVIRSAGCI PSNIVWDLLA SICPAKAKDV 420 CWRLCPHGA RDTQNCRLLY SYLNDRQRHG LASVEHMGMV LLPLPAFQPL PTRLRPLGGP 480

GLEVTHSSLL LAVLLPKEGL PDTAGSSPWL GKVQKMVSFN SKVEKRYYQp DDRRPNVPLK 540 GTPPPGGAWQ QSQGRGSIAP RGISAWQRPP RGRGRLWPEP ENWQHPGRGQ WPPEPGLRQS 600 QHPYSVAPAG HGFGRGQHFH RDSCPHQALL RHLESLATMS HQLQALLCPQ TKSSIPRPLQ 660 RLSSALAAPE PPGPARDSSL GPTDEAGSEC PFPRKA 696 Seq ID NO : 236 Protein Sequence Protein Accession # : NP 005282 1 11 21 31 41 51 MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM 60 LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH LAVADLSCVL VLPTRLVYHF 120 SGNHWPFGEI ACRLTGFLFY LNMYASIYFL TCISADRFLA IVHPVKSLKL RRPLYAHLAC 180 AFLHVWAVA MAPLLVSPQT VQTNHTWCL QLYREKASHH ALVSLAVAFT FPFITTVTCY 240 LLIIRSLRQG LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ 300 RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP SFEGKTNESS 360 LSAKSEL 367 Seq ID NO : 237 Protein Sequence Protein Accession 4 : NP 061113 1 11 21 31 41 51 MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD 60 GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK 120 EPHMLFDRIR LWTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST 180 ADVSTPDSEI NLTNVTDIIR VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP 234 Seq ID NO : 238 Protein Sequence Protein Accession # : NP 003458 1 11 21 31 41 51 MEGISIYTSD MYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI 60 LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL 120 YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEINVYVGV WIPALLLTIP DFIFANVSEA 180 DDRYICDRFY PNDLWWVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT 240 TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI 300 LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS 352 Seq ID NO : 239 Protein Sequence Protein Accession # : Nu036338-1 1 11 21 31 41 51 MHPQWILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCNNRG SCSLFTCQNG 60 IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV 120 SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPTTT VPTTMSIPTT TTVPTTMTVS 180 TTTSVPTTTS IPTTTSVPVT TTVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA 240 IRREPTSSPL YSYTTDGNDT VTESSDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL 300 VLLALLGVII AKKYFFKKEV QQLSVSFSSL QIKALQNAVE KEVQAEDNIY IENSLYATD 359 Seq ID NO : 240 Protein Sequence Protein Accession # : NP 004923. 1 1 11 21 31 41 51 MRTYRYFLLL FWVGQPYPTL STPLSKRTSG FPAKKRALEL SGNSKNELNR SKRSWMWNQF 60 FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL FIINENTGDI QATKRLDREE 120 KPVYILRAQA INRRTGRPVE PESEFIIKIH DINDNEPIFT KEVYTATVPE MSDVGTFWQ 180 VTATDADDPT YGNSAKWYS ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQWIQAKD 240 MGGQMGGLSG TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN 300 AEIEYSITDG EGLDMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS NPYVEPRFLY 360 LGPFKDSATV RIWEDVDEP PVFSKLAYIL QIREDAQINT TIGSVTAQDP DAARNPVKYS 420 VDRHTDMDRI FNIDSGNGSI FTSKLLDRET LLWHNITVIA TEINNPKQSS RVPLYIKVLD 480 VNDNAPEFAE FYETFVCEKA KADQLIQTLH AVDKDDPYSG HQFSFSLAPE AASGSNFTIQ 540 DNKDNTAGIL TRKNGYNRHE MSTYLLPWI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC 600 HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE DIRDNIVSYN 660 DEGGGEEDTQ AFDIGTLRNP EAIEDNKLRR DIVPEALFLP RRTPTARDNT DVRDFINQRL 720 KENDTDPTAP PYDSLATYAY EGTGSVADSL SSLESVTTDA DQDYDYLSDW GPRFKKLADM 780 YGGVDSDKDS 790 Seq ID NO : 241 Protein Sequence Protein Accession # : BAB14227. 1 1 11 21 31 41 51 ( MRRLTRRLVL PVFGVLWITV LLFFWVTKRK LEVPTGPEVQ TPKVWSLFFK VAGMSPWAPQ 60 VPVSPTPPYQ RGHLPTGGHL AVCHFPCLLQ EAQFHLQTQV FLQVRCTLLV YCTDLPPTSI 120 IITFHNEARS TLLRTIRSVL NRTPTHLIRE IILVDDFSND PDDCKQLIKL PKVKCLRNNE 180 RQGLVRSRIR GADIAQGTTL TFLDSHCEVN RDWLQPLLHR VKEDYTRWC PVIDIINLDT 240 FTYIESASEL RGGFDWSLHF QWEQLSPEQK ARRLDPTEPI RTPIIAGGLF VIDKAWFDYL 300 GKYDMDMDIW GGENFEISFR VWMCGGSLEI VPCSRVGHVF RKKHPYVFPD GNANTYIKNT 360 KRTAEVWMDE YKQYYYAARP FALERPFGNV ESRLDLRKNL RCQSFKWYLE NIYPELSIPK 420 ESSIQKGNIR QRQKCLESQR QNNQETPNLK LSPCAKVKGE DAKSQVWAFT YTQQILQEEL 480 CLSVITLFPG APWLVLCKN GDDRQQWTKT GSHIEHIASH LCLDTDMFGD GTENGKEIW 540 NPCESSLMSQ HWDMVSS 557 Seq ID NO : 242 Protein Sequence Protein Accession # : AAH10659

1 11 21 31 41 51 MRRLTRRLVL PVFGVLWITV LLFFWVTKRK LEVPTGPEVQ TPKPSDADWD DLWDQFDERR 60 YLNAKKWRVG DDPYKLYAFN QRESERISSN RAIPDTRHLR CTLLVYCTDL PPTSIIITFH 120 NEARSTLLRT IRSVLNRTPT HLIREIILVD DFSNDPDDCK QLIKLPKVKC LRNNERQGLV 180 RSRIRGADIA QGTTLTFLDS HCEVNRDWLQ PLLHRVKEDY TRWCPVIDI INLDTFTYIE 240 SASELRGGFD WSLHFQWEQL SPEQKARRLD PTEPIRTPII AGGLFVIDKA WFDYLGKYDM 300 DMDIWGGENF EISFRVWMCG GSLEIVPCSR VGHVFRKKHP YVFPDGNANT YIKNTKRTAE 360 VWMDEYKQYY YAARPFALER PFGNVESRLD LRKNLRCQSF KWYLENIYPE LSIPKESSIQ 420 KGNIRQRQKC LESQRQNNQE TPNLKLSPCA KVKGEDAKSQ VWAFTYTQQI LQEELCLSVI 480 TLFPGAPWL VLCKNGDDRQ QWTKTGSHIE HIASHLCLDT DMFGDGTENG KEIWNPCES 540 SLMSQHWDMV SS 552 Seq ID NO : 243 Protein Sequence Protein Accession # : AAH10659. 1 1 11 21 31 41 51 I I ( I MRRLTRRLVL PVFGVLWITV LLFFWVTKRK LEVPTGPEVQ TPKPSDADWD DLWDQFDERR 60 YLNAKKWRVG DDPYKLYAFN QRESERISSN RAIPDTRHLS VLNRTPTHLI REIILVDDFS 120 NDPDDCKQLI KLPKVKCLRN NERQGLVRSR IRGADIAQGT TLTFLDSHCE VNRDWLQPLL 180 HRVKEDYTRV VCPVIDIINL DTFTYIESAS ELRGGFDWSL HFQWEQLSPE QKARRLDPTE 240 PIRTPIIAGG LFVIDKAWFD YLGKYDMDMD IWGGENFEIS FRVWMCGGSL EIVPCSRVGH 300 VFRKKHPYVF PDGNANTYIK NTKRTAEVWM DEYKRYYYAA RPFALERPFG NVESRLDLRK 360 NLRCQSFKWY LENIYPELSI PKESSIQKGN IRQRQKCLES QRQNNQETPN LKLSPCAKVK 420 GEDAKSQVWA FTYTQQILQE ELCLSVITLF PGAPWLVLC KNGDDRQQWT KTGSHIEHIA 480 SHLCLDTDMF GDGTENGKEI WNPCESSLM SQHWDMVSS 519 Seq ID NO : 244 Protein Sequence Protein Accession # : NP 078848. 1 1 11 21 31 41 51 MNGKVWSGPG FGALTSPRAH SDFLDSHCEV NRDWLQPLLH RVKEDYTRW CPVIDIINLD 60 TFTYIESASE LRGGFDWSLH FQWEQLSPEQ KARRLDPTEP IRTPIIAGGL FVIDKAWFDY 120 LGKYDMDMDI WGGENFEISF RVWMCGGSLE IVPCSRVGHV FRKKHPYVFP DGNANTYIKN 180 TKRTAEVWMD EYKQYYYAAR PFALERPFGN VESRLDLRKN LRCQSFKWYL ENIYPELSIP 240 KESSIQKGNI RQRQKCLESQ RQNNQETPNL KLSPCAKVKG EDAKSQVWAF TYTQQILQEE 300 LCLSVITLFP GAPWLVLCK NGDDRQQWTK TGSHIEHIAS HLCLDTDMFG DGTENGKEIV 360 VNPCESSLMS QHWDMVSS 378 Seq ID NO : 245 Protein Sequence Protein Accession # : NP 001209. 1 1 11 21 31 41 51 MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL 60 HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120 HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180 PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240 NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL 300 SLGIILSLAL AGILGICIW WSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA 354 Seq ID NO : 246 Protein Sequence Protein Accession # : BC000278 1 11 21 31 41 51 MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL 60 HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120 HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180 PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240 NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QGIILSLALA 300 GILGICIWV VSIWLFRRKS IKKGDNKGVI YKPATKMETE AHA 343 Seq ID NO : 247 Protein Sequence Protein Accession # : NP 006623. 1 1 11 21 31 41 51 MQVDETLIPR KGPSLCSARY GIALVLHFCN FTTIAQNVIM NITMVAMVNS TSPQSQLNDS 60 SEVLPVDSFG GLSKAPKSLP AKSSILGGQF AIWEKWGPPQ ERSRLCSIAL SGMLLGCFTA 120 ILIGGFISET LGWPFVFYIF GGVGCVCCLL WFWIYDDPF SYPWISTSEK EYIISSLKQQ 180 VGSSKQPLPI KAMLRSLPIW SICLGCFSHQ WLVSTMWYI PTYISSVYHV NIRDNGLLSA 240 LPFIVAWVIG MVGGYLADFL LTKKFRLITV RKIATILGSL PSSALIVSLP YLNSGYITAT 300 ALLTLSCGLS TLCQSGIYIN VLDIAPRYSS FLMGASRGFS SIAPVIVPTV SGFLLSQDPE 360 FGWRNVFFLL FAVNLLGLLF YLIFGEADVQ EWAKERKLTR L 401 Seq ID NO : 248 Protein Sequence Protein Accession # : NP 003049. 1 1 11 21 31 41 51 MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR CRSPGVAELS 60 LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST FDCVDPLASL DTNRSRLPLG 120 PCRDGWVYET PGSSIVTEFN LVCANSWMLD LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL 180 LTTVLINAAA GVLMAISPTY TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF 240 YQVAYTVGLL VLAGVAYALP HWRWLQFTVA LPNFFFLLYY WCIPESPRWL ISQNKNAEAM 300 RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI LMYNWFTSSV 360 LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR IGRRYPWAAS NMVAGAACLA 420

SVFIPGDLQW LKIIISCLGR MGITMAYEIV CLVNAELYPT FIRNLGVHIC SSMCDIGGII 480 TPFLVYRLTN IWLELPLMVF GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE 540 KMIYLQVQKL DIPLN 555 Seq ID NO : 249 Protein Sequence Protein Accession # : Eos sequence 1 11 21 31 41 51 MQPAIQVWFG EDLPLSPRSP LTPRHGPGLA NVCQYDEWIA VRHEATLLPM QEDLSIWLSG'60 LLGIKVKAEK LLEELDNGVL LCQLIDVLQN MVKTCNSEES GNFPMRKVPC KKDAASGSFF 120 ARDNTANFLH WCRDIGVDET YLFESEGLVL HKDPRQVYLC LLEIGRIVSR YGVEPPVLVK 180 LEKEIELEET LLNTSGPEDS ISIPKSCCRH EELHEAVKHI AEDPPCSCSH RFSIEYLSEG 240 RYRLGDKILF IRMLHGKHVM VRVGGGWDTL QGFLLKYDPC RILQFATLEQ KILAFQKGVS 300 NESVPDSPAR TPQPPEMNPL SAVNMFQKQN SKPSVPVSIP KSKEKQGRPP GALVPASSLK 360 GGNLGSMSVR SKLPNSPAAS SHPKLKSSKG ITKKPQAPSN NASSSLASLN PVGKNTSSPA 420 LPRTAPCISE SPRKCISSPN TPKAKVIPAQ NSADLPESTL LPNKCSGKTQ PKYLKHNHIS 480 SRDNAVSHLA AHSNSSSKCP KLPKANIPVR PKPSFQSSAK MTKTSSKTIA TGLGTQSQPS 540 DGAPQAKPVP AQKLKSALNL NQPVSVSSVS PVKATQKSKD KNIVSATKKQ PQNKSAFQKT 600 GPSSLKSPGR TPLSIVSLPQ SSTKTQTAPK SAQTVAKSQH STKGPPRSGK TPASIRKPPS 660 SVKDADSGDK KPTAKKKEDD DHYFVMTGSK KPRK 694 Seq ID NO : 250 Protein Sequence Protein Accession # : NP 001035. 1 1 11 21 31 41 51 MSKSKCSVGL MSSWAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP RQSPVEAQDR 60 ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 120 GQFNREGAAG VWKICPILKG VGFTVILISL YVGFFYNVII AWALHYLFSS FTTELPWIHC 180 NNSWNSPNCS DAHPGDSSGD SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL 240 TACLVLVIVL LYFSLWKGVK TSGKWWITA TMPYWLTAL LLRGVTLPGA IDGIRAYLSV 300 DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT SINSLTSFSS 360 GFWFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT LPLSSAWAW FFIMLLTLGI 420 DSAMGGMESV ITGLIDEFQL LHRHRELFTL FIVLATFLLS LFCVTNGGIY VFTLLDHFAA 480 GTSILFGVLI EAIGVAWFYG VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFWWSI 540 VTFRPPHYGA YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD 600 RELVDRGEVR QFTLRHWLKV 620 Seq ID NO : 251 Protein Sequence Protein Accession # : NP 071356. 1 1 11 21 31 41 51 MPLGHIMRLD LEKIALEYIV PCLHEVGFCY LDNFLGEWG DCVLERVKQL HCTGALRDGQ 60 LAGPRAGVSK RHLRGDQITW IGGNEEGCEA ISFLLSLIDR LVLYCGSRLG KYYVKERSKA 120 MVACYPGNGT GYVRHVDNPN GDGRCITCIY YLNKNWDAKL HGGILRIFPE GKSFIADVEP 180 IFDRLLFFWS DRRNPHEVQP SYATRYAMTV WYFDAEERAE AKKKFRNLTR KTESALTED 239 Seq ID NO : 252 Protein Sequence Protein Accession # : NP 647475. 1 1 11 21 31 41 51 MSGAPTAGAA LMLCAATAVL LSAQGGPVQS KSPRFASWDE MNVLAHGLLQ LGQGLREHAE 60 RTRSQLSALE RRLSACGSAC QGTEGSTDLP LAPESRVDPE VLHSLQTQLK AQNSRIQQLF 120 HKVAQQQRHL EKQHLRIQHL QSQFGLLDHK HLDHEVAKPA RRKRLPEMAQ PVDPAHNVSR 180 LHRLPRDCQE LFQVGERQSG LFEIQPQGSP PFLVNCKMTS DGGWTVIQRR HDGSVDFNRP 240 WEAYKAGFGD PHGEFWLGLE KVHSITGDRN SRLAVQLRDW DGNAELLQFS VHLGGEDTAY 300 SLQLTAPVAG QLGATTVPPS GLSVPFSTWD QDHDLRRDKN CAKSLSGGWW FGTCSHSNLN 360 GQYFRSIPQQ RQKLKKGIFW KTWRGRYYPL QATTMLIQPM AAEAAS 406 Seq ID NO : 253 Protein Sequence Protein Accession # : NP 001207. 1 1 11 21 31 41 51 MAPLCPSPWL PLLIPAPAPG LTVQLLLSLL LLMPVHPQRL PRMQEDSPLG GGSSGEDDPL 60 GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP KSEEEGSLKL EDLPTVEAPG 120 DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP RVSPACAGRF QSPVDIRPQL AAFCPALRPL 180 ELLGFQLPPL PELRLRNNGH SVQLTLPPGL EMALGPGREY RALQLHLHWG AAGRPGSEHT 240 VEGHRFPAEI HWHLSTAFA RVDEALGRPG GLAVLAAFLE EGPEENSAYE QLLSRLEEIA 300 EEGSETQVPG LDISALLPSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM LSAKQLHTLS 360 DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA AEPVQLNSCL AAGDILALVF 420 GLLFAVTSVA FLVQMRRQHR RGTKGGVSYR PAEVAETGA 459 Seq ID NO : 254 Protein Sequence Protein Accession # : NP 003030. 1 1 11 21 31 41 51 1 1 1 1 1 1 MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE 60 FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR 120 VATSFELIII SRLLVGICAG VSSNWPMYL GELAPKNLRG ALGWPQLFI TVGILVAQIF 180 GLRNLLANVD GWPILLGLTG VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW 240 DSVDREVAEI RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 300 DQIYLSAGVP EEHVQYVTAG TGAVNWMTF CAVFWELLG RRLLLLLGFS ICLIACCVLT 360 AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT EIFLQSSRPS AFMVGGSVHW 420 LSNFTVGLIF PFIOEGLGPY SFIVFAVICL LTTIYIFLIV PETKAKTFIE INQIFTKMNK 480 VSEVYPEKEE LKELPPVTSE Q 501

Seq ID NO : 255 Protein Sequence Protein Accession # : NP 001243. 1 1 11 21 31 41 51 MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLWCIQR FAQAQQQLPL ESLGWDVAEL 60 QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA 120 SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN 180 TDETFFGVQW VRP 193 Seq ID NO : 256 Protein Sequence Protein Accession # : NP 060562. 2 1 11 21 31 41 51 1 1 1 1 1 1 MLPTSFVEQK KKAGVFEQIT KTHGTIIGIT SGIVLVLLII SILVQVKQPR KKVMACKTAF 60 NKTGFQEVFD PPHYELFSLR DKEISADLAD LSEELDNYQR MRRSSTASRC IHDHHCGSQA 120 SSVKQSRTNL SSMELPLRND FAQPQPMKTF NSTFKKSSYT FKQGHECPEQ ALEDRVMEEI 180 PCEIYVRGRE DSAQASISID F 201 Seq ID NO : 257 Protein Sequence Protein Accession # : Eos sequence 1 11 21 31 41 51 IIAATINNAS MTSPIDNAGL AADDFKMNAS LQTQISTDAE AVSSAKSEIM ELKQVLQSLQ 60 HELQSVLAMQ SSPEGTLADT EAGYVAQLSE IKMYISILEE QICQIRGETE YQNTEYAQLQ 120 DIKTRLEVEI ETYHRLLGGE GGSEAREAES KG 152 Seq ID NO : 258 Protein Sequence Protein Accession # : NP 003256. 1 1 11 21 31 41 51 MRQTLPCIYF WGGLLPFGML CASSTTKCTV SHEVADCSHL KLTQVPDDLP TNITVLNLTH 60 NQLRRLPAAN FTRYSQLTSL DVGFNTISKL EPELCQKLPM LKVLNLQHNE LSQLSDKTFA 120 FCTNLTELHL MSNSIQKIKN NPFVKQKNLI TLDLSHNGLS STKLGTQVQL ENLQELLLSN 180 NKIQALKSEE LDIFANSSLK KLELSSNQIK EFSPGCFHAI GRLFGLFLNN VQLGPSLTEK 240 LCLELANTSI RNLSLSNSQL STTSNTTFLG LKWTNLTMLD LSYNNLNWG NDSFAWLPQL 300 EYFFLEYNNI QHLFSHSLHG LFNVRYLNLK RSFTKQSISL ASLPKIDDFS FQWLKCLEHL 360 NMEDNDIPGI KSNMFTGLIN LKYLSLSNSF TSLRTLTNET FVSLAHSPLH ILNLTKNKIS 420 KIESDAFSWL GHLEVLDLGL NEIGQELTGQ EWRGLENIFE IYLSYNKYLQ LTRNSFALVP 480 SLQRLMLRRV ALKNVDSSPS PFQPLRNLTI LDLSNNNIAN INDDMLEGLE KLEILDLQHN 540 NLARLWKHAN PGGPIYFLKG LSHLHILNLE SNGFDEIPVE VFKDLFELKI IDLGLNNLNT 600 LPASVFNNQV SLKSLNLQKN LITSVEKKVF GPAFRNLTEL DMRFNPFDCT CESIAWFVNW 660 INETHTNIPE LSSHYLCNTP PHYHGFPVRL FDTSSCKDSA PFELFFMINT SILLIFIFIV 720 LLIHFEGWRI SFYWNVSVHR VLGFKEIDRQ TEQFEYAAYI IHAYKDKDWV WEHFSSMEKE 780 DQSLKFCLEE RDFEAGVFEL EAIVNSIKRS RKIIFVITHH LLKDPLCKRF KVHHAVQQAI 840 EQNLDSIILV FLEEIPDYKL NHALCLRRGM FKSHCILNWP VQKERIGAFR HKLQVALGSK 900 NSVH 904 Seq ID NO : 259 Protein Sequence Protein Accession # : NP 000570. 1 1 11 21 31 41 51 MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR 60 LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII 120 LLTIDRYLAV VHAVFALKAR TVTFGWTSV ITWWAVFAS LPGIIFTRSQ KEGLHYTCSS 180 HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI 240 MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV 300 GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL 352 Seq ID NO : 260 Protein Sequence Protein Accession # : Eos sequence 1 11 21 31 41 51 1 1 1 1 1 1 PQGPPGPPGI PGAKGELGLP GAPGIDGEKG PKGQKGDPGE PGPAGLKGEA GEMGLSGLPG 60 ADGLKGEKGE SASDSLQESL AQLIVEPGPP GPPGPPGPMG LQGIQGPKGL DGAKGEKGAS 120 GERGPSGLPG PVGPPGLIGL PGTKGEKGRP GEPGLDGFPG PRGEKGDRSE RGEKGERGVP 180 GRKGVKGQKG EPGPPGLDQP CPVGPDGLPV PGCWHK 216 Seq ID NO : 261 Protein Sequence Protein Accession # : NP 004852. 1 1 11 21 31 41 51 1 1 1 1 1 1 MLPPQKKPWE SMAKGLVLGA LFTSFLLLVY SYAVPPLHAG LASTTPEAAA SCSPPALEPE 60 AVIRANGSAG ECQPRRNIVF LKTHKTASST LLNILFRFGQ KHRLKFAFPN GRNDFDYPTF 120 FARSLVQDYR PGACFNIICN HMRFHYDEVR GLVPTNAIFI TVLRDPARLF ESSFHYFGPV 180 VPLTWKLSAG DKLTEFLQDP DRYYDPNGFN AHYLRNLLFF DLGYDNSLDP SSPQVQEHIL 240 EVERRFHLVL LQEYFDESLV LLKDLLCWEL EDVLYFKLNA RRDSPVPRLS GELYGRATAW 300 NMLDSHLYRH FNASFWRKVE AFGRERMARE VAALRHANER MRTICIDGGH AVDAAAIQDE 360 AMQPWQPLGT KSILGYNLKK SIGQRHAQLC RRMLTPEIQY LMDLGANLWV TKLWKFIRDF 420 LRW 423 Seq ID NO : 262 Protein Sequence Protein Accession # : NP061130. 1 1 11 21 31 41 51

I I I I I I MASVLSRRLG KRSLLGARVL GPSASEGPSA APPSEPLLEG AAPQPFTTSD DTPCQEQPKE 60 VLKAPSTSGL QQVAFQPGQK VYVWYGGQEC TGLVEQHSWM EGQVTVWLLE QKLQVCCRVE 120 EVWLAELQGP CPQAPPLEPG AQALAYRPVS RNIDVPKRKS DAVEMDEMMA AMVLTSLSCS 180 PWQSPPGTE ANFSASRAAC DPWKESGDIS DSGSSTTSGH WSGSSGVSTP SPPHPQASPK 240 YLGDAFGSPQ TDHGFETDPD PFLLDEPAPR KRKNSVKVMY KCLWPNCGKV LRSIVGIKRH 300 VKALHLGDTV DSDQFKREED FYYTEVQLKE ESAAAAAAAA AGTPVPGTPT SEPAPTPSMT 360 GLPLSALPPP LHKAQSSGPE HPGPESSLPS GALSKSAPGS FWHIQADHAY QALPSFQIPV 420 SPHIYTSVSW AAAPSAACSL SPVRSRSLSF SEPQQPAPAM KSHLIVTSPP RAQSGARKAR 480 GEAKKCRKVY GIEHRDQWCT ACRWKKACQR FLD 513 Seq ID NO : 263 Protein Sequence Protein Accession # : AB058765. 2 1 11 21 31 41 51 MRENYETLVS VGTAELLPLS AFLSPSEPGR AVGGGSHADE GQEPAGCGDP QGGQPRHSLH 60 LTALVQLVKE IPEFLFGEVK GAMDSPESES RGASLDGERA SPEAAAAREP CPLRGLLSCL 120 PDGPTSQPHL ATTPTDSSCS SGPTGDGVQG SPLPIKTADK PWPTRKEGPG ALGGEPSPPT 180 HSPSRRKSHR GQERGTSEAG ISPGNSPLQG LINCLKEILV PGPRHPETSP SFLPPLPSLG 240 TSRLTRADLG PGSPPWAVKT EAVSGDCPLQ GLLHCLKELP EAQDRHPSPS GVGNRRLQEN 300 PGAWKRGSGG PGYLLTPPPH PDLGAGGLLS VKMENSWVQS PPGPASCQPG RQPLSPSATG 360 DTRGVPQPSW GPEAQAASAS SSPLEALEAC LKGIPPNGSS PSQLPPTSCS QNPQPGDSRS 420 QKPELQPHRS HSEEATREPV LPLGLQSCVR DGPSRPLAPR GTPTSFSSSS STDWDLDFGS 480 PVGNQGQHPG KGSPPGSSPL QGLENCLKEI PVPVLRPAWP CSSAADRGPR RAEPRNWTAD 540 KEGLRAEACE SARLGQGRGE APTRSLHLVS PQVFTSSCVP ACHQRGFKDP GATRPGVWRW 600 LPEGSAPKPS PLHCLESALR GILPVRPLRF ACVGGPSPSP SPGSSSSFSG SEGEDPRPEP 660 ELWKPLPQER DRLPSCKPPV PLSPCPGGTP AGSSGGSPGE DPRRTEPRYC SGLGAGTAQD 720 PCPVSQLEKR PRVSEASRGL ELGHGRPRVA AKTHERLLPQ GPPELPSESP PPELPPPEAA 780 PPVLPASSLQ PPCHCGKPLQ QELHSLGAAL AEKLDRLATA LAGLAQEVAT MRTQVNRLGR 840 RPQGPGPMGQ ASWMWTLPRG PRWAHGPGHR HLPYWRQKGP TRPKPKILRG QGESCRAGDL 900 QGLSRGTARR ARPLPPDAPP AEPPGLHCSS SQQLLSSTPS CHAAPPAHPL LAHTGGHQSP 960 LPPLVPAALP LQGASPPAAS ADADVPTSGV APDGIPERPK EPSSLLGGVQ RALQEELWGG 1020 EHRDPRWGAH 1030 Seq ID NO : 264 Protein Sequence Protein Accession # : AL831935. 1 1 11 21 31 41 51 PAGCGDPQGG QPRHSLHLTA LVQLVKEIPE FLFGEVKGAM DSPESESRGA SLDGERASPE 60 AAAREPCPLR GLLSCLPDGP TSQPHLATTP TDSSCSSGPT GDGVQGSPLP IKTADKPWPT 120 RKEGPGALGG EPSPPTHSPS RRKSHRGQER GTSEAGISPG NSPLQGLINC LKEILVPGPR 180 HPETSPSFLP PLPSLGTSRL TRADLGPGSP PWAVKTEAVS GDCPLQGLLH CLKELPEAQD 240 RHPSPSGVGN RRLQENPGAW KRGSGGPGYL LTPPPHPDLG AGGLLSVKME NSWVQSPPGP 300 ASCQPGRQPL SPSATGDTRG VPQPSWGPEA QAASASSSPL EALEACLKGI PPNGSSPSQL 360 PPTSCSQNPQ PGDSRSQKPE LQPHRSHSEE ATREPVLPLG LQSCVRDGPS RPLAPRGTPT 420 SFSSSSSTDW DLDFGSPVGN QGQHPGKGSP PGSSPLQGLE NCLKEIPVPV LRPAWPCSSA 480 ADRGPRRAEP RNWTADKEGS APKPSPLHCL ESALRGILPV RPLRFACVGG PSPSPSPGSS 540 SSFSGSEGED PRPEPDLWKP LPQERDRLPS CKPPVPLSPC PGGTPAGSSG GSPGEDPRRT 600 EPRYCSGLGA GEPGVS 616 Seq ID NO : 265 Protein Sequence Protein Accession # : AAH29071. 1 1 11 21 31 41 51 f t t ! (f RTRGRTRGRL RSGVMMPLAE AGALAQGGGP SATEWACILR RKTPRHKQPT LLMVRASRRS 60 GKTSAVLKAG RQSVSGRKNS TSKDLVTLGA SSLREERGHP LHPRHRKAVH LRTRGRTRGW 120 VQTLARMSRR TRGPVERAAA AAAAAAGGDA GHAPFPPPPA ADGARAPRSP GQVTPRGLRL 180 RLPRRESLLR GLCRPLRPLL GFRESDSAKP ASLRLLQHTP SARRNYRIAG ARLMRSNYPP 240 PLSSAALRGA GPTRRN 256 Seq ID NO : 266 Protein Sequence Protein Accession # : NP 002095. 1 1 11 21 31 41 51 MTKFSSFSLF FLIVGAYMTH VCFNMEIIGG KEVSPHSRPF MASIQYGGHH VCGGVLIDPQ 60 WVLTAAHCQY RFTKGQSPTV VLGAHSLSKN EASKQTLEIK KFIPFSRVTS DPQSNDIMLV 120 KLQTAAKLNK HVKMLHIRSK TSLRSGTKCK VTGWGATDPD SLRPSDTLRE VTVTVLSRKL 180 CNSQSYYNGD PFITKDMVCA GDAKGQKDSC KGDSGGPLIC KGVFHAIVSG GHECGVATKP 240 GIYTLLTKKY QTWIKSNLVP PHTN 264 Seq ID NO : 257 Protein Sequence Protein Accession # : NP 443179. 1 1 11 21 31 41 51 MQVNTLFETS QVPDWSDPPQ VQVQETVRET ISCSQMPAFS EPAGEESPFT GTTTISFSNL 60 GGVHKENASL AQHSEVKPCT CGPQQEEKQD RDGNIPDNFR EDLKYEQSIS EANDETMSPG 120 VFSRHLPKDA RADFREPVAV SVASPEPTDT ALTLENVCDE PRDREAVCAM ECFEASDQGT 180 CFDTIDSLVG TPVDNYSPQE ICSVDTELAE GQNKVSDLCS SNDKTLEVFF QTQVSETSVS 240 TCKSSKDGNS VMSPLFISTF TLNISHTASE GATGENLAKV EKSTYPLAST VHAGQEQPSP 300 SNSGGLDETQ LLSSENNPLV QFKEGGDKSP SPSAADTTAT PASYSSIVSF PWEKPTTLTA 360 NNECFQATRE TVTIATEVHP AKYLAVSIPE DKHAGGTEER FPRASHEKVS QFPSQVQVDH 420 ILSGATIKST KELLCRAPSV PGVPHHVLQL PEGEGFCSNS PLQVDNLSGD KSQTVDRADF 480 RSYEENFQER GSETKQGVQQ QSLSQQGSLS APDFQQSLPT TSAAQEERNL VPTAPSPASS 540 REGAGQRSGW GTRVSWAET AGEEDSQALS NVPSLSDILL EESKEYRPGN WEAGNKLKII 600

TLEASASEIW PPRQLTNSES KASDGGLIIP DKVWAVPDSL KADAWPELA PSEIAALAHS 660 PEDAESALAD SRESHKGEEP TISVHWRSLS SRGFSQPRLL ESSVDPVDEK ELSVTDSLSA 720 ASETGGKENV NNVSQDQEEK QLKMDHTAFF KKFLTCPKIL ESSVDPIDEI SVIEYTRAGK 780 PEPSETTPQG AREGGQSNDG NMGHEAEIQS AILQVPCLQG TILSENRISR SQEGSMKQEA 840 EQIQPEEAKT AIWQVLQPSE GGERIPSGCS IGQIQESSDG SLGEAEQSKK DKAELISPTS 900 PLSSCLPIMT HSSLGVDTHN STGQIHDVPE NDIVEPRKRQ YVFPVSQKRG TIENERGKPL 960 PSSPDLTRFP CTSSPEGNVT DFLISHKMEE PKIEVLQIGE TKPPSSSSSS AKTLAFISGE 1020 RELEKAPKLL QDPCQKGTLG CAKKSREREK SLEARAGKSP GTLTAVTGSE EVKRKPEAPG 1080 SGHLAEGVKK KILSRVAALR LKLEEKENIR KNSAFLKKMP KLETSLSHTE EKQDPKKPSC 1140 KREGRAPVLL KKIQAEMFPE HSGNVKLSCQ FAEIHEDSTI CWTKDSKSIA QVQRSAGDNS 1200 TVSFAIVQAS PKDQGLYYCC IKNSYGKVTA EFNLTAEVLK QLSSRQDTKG CEEIEFSQLI 1260 FKEDFLHDSY FGGRLRGQIA TEELHFGEGV HRKAFRSTVM HGLMPVFKPG HACVLKVHNA 1320 IAYGTRNNDE LIQRNYKLAA QECYVQNTAR YYAKIYAAEA QPLEGFGEVP EIIPIFLIHR 1380 PENNIPYATV EEELIGEFVK YSIRDGKEIN FLRRESEAGQ KCCTFQHWVY QKTSGCLLVT 1440 DMQGVGMKLT DVGIATLAKG YKGFKGNCSM TFIDQFKALH QCNKYCKMLG LKSLQNNNQK 1500 QKQPSIGKSK VQTNSMTVKK AGPETPGEKK T 1531 Seq ID NO : 268 Protein Sequence Protein Accession # : NP 602293. 1 1 11 21 31 41 51 ( MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 60 ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 120 MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 180 RLLQCDPSSA SQF 193 Seq ID NO : 269 Protein Sequence Protein Accession # : NP 002140. 2 1 11 21 31 41 51 MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 60 ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 120 MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 180 RLLQCDPSSA SQF 193 Seq ID NO : 270 Protein Sequence Protein Accession # : NP 003937. 1 1 11 21 31 41 51 MGNAQERPSE TIDRERKRLV ETLQADSGLL LDALLARGVL TGPEYEALDA LPDAERRVRR 60 LLLLVQGKGE AACQELLRCA QRTAGAPDPA WDWQHVGPGY RDRSYDPPCP GHWTPEAPGS 120 GTTCPGLPRA SDPDEAGGPE GSEAVQSGTP EEPEPELEAE ASKEAEPEPE PEPELEPEAE 180 AEPEPELEPE PDPEPEPDFE ERDESEDS 208 Seq ID NO : 271 Protein Sequence Protein Accession # : NP004198. 1 1 11 21 31 41 51 MGGAVVDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT 60 AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV 120 ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF 180 LILGGLLLNC CVCAALMRPL WTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL 240 GLFVPPVFW SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF 300 SMFFNGLADL AGSTAGDYGG LWFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL 360 LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE 420 VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGEWHT PETSV 465 Seq ID NO : 272 Protein Sequence Protein Accession # : NP 060705. 1 1 11 21 31 41 51 MAALTTLFKY IDENQDRYIK KLAKWVAIQS VSAWPEKRGE IRRMMEVAAA DVKQLGGSVE 60 LVDIGKQKLP DGSEIPLPPI LLGRLGSDPQ KKTVCIYGHL DVQPAALEDG WDSEPFTLVE 120 RDGKLYGRGS TDDKGPVAGW INALEAYQKT GQEIPVNVRF CLEGMEESGS EGLDELIFAR 180 KDTFFKDVDY VCISDNYWLG KKKPCITYGL RGICYFFIEV ECSNKDLHSG VYGGSVHEAM 240 TDLILLMGSL VDKRGNILIP GINEAVAAVT EEEHKLYDDI DFDIEEFAKD VGAQILLHSH 300 KKDILMHRWR YPSLSLHGIE GAFSGSGAKT VIPRKWGKF SIRLVPNMTP EWGEQVTSY 360 LTKKFAELRS PNEFKVYMGH GGKPWVSDFS HPHYLAGRRA MKTVFGVEPD LTREGGSIPV 420 TLTFQEATGK NVMLLPVGSA DDGAHSQNEK LNRYNYIEGT KMLAAYLYEV SQLKD 475 Seq ID NO : 273 Protein Sequence Protein Accession # : AF2585921 1 11 21 31 41 51 MAALTTLFKY IDENQDRYIK KLAKWVAIQS VSAWPEKRGE IRRMMEVAAA DVKQLGGSVE 60 LVDIGKQKEI PVNVRFCLEG MEESGSEGLD ELIFARKDTF FKDVDYVCIS DNYWLGKKKP 120 CITYGLRGIC YFFIEVECSN KDLHSGVYGG SVHEAMTDLI LLMGSLVDKR GNILIPGINE 180 AVAAVTEEEH KLYDDIDFDI EEFAKDVGAQ ILLHSHKKDI LMHRWRYPSL SLHGIEGAFS 240 GSGAKTVIPR KWGKFSIRL VPNMTPEWG EQVTSYLTKK FAELRSPNEF KVYMGHGGKP 300 WVSDFSHPHY LAGRRAMKTV FGVEPDLTRE GGSIPVTLTF QEATGKNVML LPVGSADDGA 360 HSQNEKLNRY NYIEGTKMLA AYLYEVSQLK D 391 Seq ID NO : 274 Protein Sequence Protein Accession # : NP060871. 1

1 11 21 31 41 51 MGGNHSHKPP VFDENEEVNF DHFQILRAIG KGSFGKVCIV QKRDTKKMYA MKYMNKQKCI 60 ERDEVRNVFR ELQIMQGLEH PFLVNLWYSF QDEEDMFMW DLLLGGDLRY HLQQNVHFTE 120 GTVKLYICEL ALALEYLQRY HIIHRDIKPD NILLDEHGHV HITDFNIATV VKGAERASSM 180 AGTKPYMAPE VFQVYMDRGP GYSYPVDWWS LGITAYELLR GWRPYEIHSV TPIDEILNMF 240 KVERVHYSST WCKGMVALLR KLLTKDPESR VSSLHDIQSV PYLADMNWDA VFKKALMPGF 300 VPNKGRLNCD PTFELEEMIL ESKPLHKKKK RLAKNRSRDG TKDSCPLNGH LQHCLETVRE 360 EFIIFNREKL RRQQGQGSQL LDTDSRGGGQ AQSKLQDGCN NNLLTHTCTR GCSS 414 Seq ID NO : 275 Protein Sequence Protein Accession # : NP 004198. 1 1 11 21 31 41 51 MGGAWDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT 60 AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV 120 ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF 180 LILGGLLLNC CVCAALMRPL WTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL 240 GLFVPPVFW SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF 300 SMFFNGLADL AGSTAGDYGG LWFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL 360 LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE 420 VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGEWHT PETSV 465 Seq ID NO : 276 Protein Sequence Protein Accession # : NP 006589. 1 1 11 21 31 41 51 MPTNFTWPV EAHADGGGDE TAERTEAPGT PEGPEPERPS PGDGNPRENS PFLNNVEVEQ 60 ESFFEGKNMA LFEEEMDSNP MVSSLLNKLA NYTNLSQGW EHEEDEESRR REAKAPRMGT 120 FIGVYLPCLQ NILGVILFLR LTWIVGVAGV LESFLIVAMC CTCTMLTAIS MSAIATNGW 180 PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGAMYILGT IEIFLTYISP GAAIFQAEAA 240 GGEAAAMLHN MRVYGTCTLV LMALWFVGV KYVNKLALVF LACWLSILA IYAGVIKSAF 300 DPPDIPVCLL GNRTLSRRSF DACVKAYGIH NNSATSALWG LFCNGSQPSA ACDEYFIQNN 360 VTEIQGIPGA ASGVFLENLW STYAHAGAFV EKKGVPSVPV AEESRASTLP YVLTDIAASF 420 TLLVGIYFPS VTGIMAGSNR SGDLKDAQKS IPTGTILAIV TTSFIYLSCI VLFGACIEGV 480 VLRDKFGEAL QGNLVIGMLA WPSPWVIVIG SFFSTCGAGL QTLTGAPRLL QAIARDGIVP 540 FLQVFGHGKA NGEPTWALLL TVLICETGIL IASLDSVAPI LSMFFLMCYL FVNLACAVQT 600 LLRTPNWRPR FKFYHWTLSF LGMSLCLALM FICSWYYALS AMLIAGCIYK YIEYRGAEKE 660 WGDGIRGLSL NAARYALLRV EHGPPHTKNW RPQVLVMLNL DAEQAVKHPR LLSFTSQLKA 720 GKGLTIVGSV LEGTYLDKHM EAQRAEENIR SLMSTEKTKG FCQLWSSSL RDGMSHLIQS 780 AGLGGLKHNT VLMAWPASWK QEDNPFSWKN FVDTVRDTTA AHQALLVAKN VDSFPQNQER 840 FGGGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQVDDNSIQ MKKDLQMFLY 900 HLRISAEVEV VEMVENDISA FTYERTLMME QRSQMLKQMQ LSKNEQEREA QLIHDRNTAS 960 HTAAAARTQA PPTPDKVQMT WTREKLIAEK YRSRDTSLSG FKDLFSMKPD QSNVRRMHTA 1020 VKLNGWLNK SQDAQLVLLN MPGPPKNRQG DENYMEFLEV LTEGLNRVLL VRGGGREVIT 1080 IYS 1083 Seq ID NO : 277 Protein Sequence Protein Accession # : NP 004576. 1 1 11 21 31 41 51 MASPHQEPKP GDLIEIFRLG YEHWALYIGD GYVIHLAPPS EYPGAGSSSV FSVLSNSAEV 60 KRGRLEDWG GCCYRVNNSL DHEYQPRPVE VIISSAKEMV GQKMKYSIVS RNCEHFVAQL 120 RYGKSRCKQV EKAKVEVGVA TALGILWAG CSFAIRRYQK KATA 164 Seq ID NO : 278 Protein Sequence Protein Accession # : NP 004687. 1 1 11 21 31 41 51 MLKREGKVQP YTKTLDGGWG WMIVIHFFLV NVFVMGMTKT FAIFFWFQE EFEGTSEQIG 60 WIGSIMSSLR FCAGPLVAII CDILGEKTTS ILGAFWTGG YLISSMATSI PFLCVTMGLL 120 PGLGSAFLYQ VAAWTTKYF KKRLALSTAI ARSGMGLTFL LAPFTKFLID LYDWTGALIL 180 FGAIALNLVP SSMLLRPIHI KSENNSGIKD KGSSLSAHGP EAHATETHCH ETEESTIKDS 240 TTQKAGLPSK NLTVSQNQSE EFYNGPNRNR LLLKSDEESD KVISWSCKQL FDISLFRNPF 300 FYIFTWSFLL SQLAYFIPTF HLVARAKTLG IDIMDASYLV SVAGILETVS QIISGWVADQ 360 NWIKKYHYHK SYLILCGITN LLAPLATTFP LLMTYTICFA IFAGGYLALI LPVLVDLCRN 420 STVNRFLGLA SFFAGMAVLS GPPIAGWLYD YTQTYNGSFY FSGICYLLSS VSFFFVPLAE 480 RWKNSLT 487 Seq ID NO : 279 Protein Sequence Protein Accession # : NP_000349. 1 1 11 21 31 41 51 MALFVRLLAL ALALALGPAA TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA VQKVIGTNRK 60 YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA LPLSNLYETL GWGSTTTQL 120 YTDRTEKLRP EMEGPGSFTI FAPSNEAWAS LPAEVLDSLV SNVNIELLNA LRYHMVGRRV 180 LTDELKHGMT LTSMYQNSNI QIHHYPNGIV TVNCARLLKA DHHATNGWH LIDKVISTIT 240 NNIQQIIEIE DTFETLRAAV AASGLNTMLE GNGQYTLLAP TNEAFEKIPS ETLNRILGDP 300 EALRDLLNNH ILKSAMCAEA IVAGLSVETL EGTTLEVGCS GDMLTINGKA IISNKDILAT 360 NGVIHYIDEL LIPDSAKTLF ELAAESDVST AIDLFRQAGL GNHLSGSERL TLLAPLNSVF 420 KDGTPPIDAH TRNLLRNHII KDQLASKYLY HGQTLETLGG KKLRVFVYRN SLCIENSCIA 480 AHDKRGRYGT LFTMDRVLTP PMGTVMDVLK GDNRFSMLVA AIQSAGLTET LNREGVYTVF 540 APTNEAFRAL PPRERSRLLG DAKELANILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS 600 LKNNWSVNK EPVAEPDIMA TNGWHVITN VLQPPANRPQ ERGDELADSA LEIFKQASAF 660

SRASQRSVRL APVYQKLLER MKH 683 Seq ID NO : 280 Protein Sequence Protein Accession # : NP 663623 1 11 21 31 41 51 MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA FYGITSNLVL 60 FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL GRARAILLSL ALYLLGMLAF 120 PLLAAPATRA ALCGSARLLN CTAPGPDAAA RCCSPATFAG LVLVGLGVAT VKANITPFGA 180 DQVKDRGPEA TRRFFNWFYW SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFWF 240 LCGQSVFITK PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK 300 MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR IPEISNITTT 360 PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS SLKRIAVGMF FVMCSAFAAG 420 ILESKRLNLV KEKTINQTIG NWYHAADLS LWWQVPQYLL IGISEIFASI AGLEFAYSAA 480 PKSMQSAIMG LFFFFSGVGS FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA 540 AIQGATLLLF LIISVKYDHH RDHQRSRANG VPTSRRA 577 Seq ID NO : 281 Protein Sequence Protein Accession # : NP 001241. 1 1 11 21 31 41 51 ( MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL 60 PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV 120 LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLWQQAGTN 180 KTDWCGPQD RLRALWIPI IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD 240 DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ 277 Seq ID NO : 282 Protein Sequence Protein Accession # :-NP_003833. 3 1 11 21 31 41 51 ( MEQRGQNAPA ASGARKRHGP GPREARGARP GLRVPKTLVL WAAVLLLVS AESALITQQD 60 LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 120 SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 180 KESGTKHSGE APAVEETVTS SPGTPASPCS LSGIIIGVTV AAWLIVAVF VCKSLLWKKV 240 LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 300 NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK 360 LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED 420 HLLSSGKFMY LEGNADSAMS 440 Seq ID NO : 283 Protein Sequence Protein Accession # : NP 671716. 1 1 11 21 31 41 51 MEQRGQNAPA ASGARKRHGP GPREARGARP GLRVPKTLVL WAAVLLLVS AESALITQQD 60 LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 120 SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 180 KESGIIIGVT VAAWLIVAV FVCKSLLWKK VLPYLKGICS GGGGDPERVD RSSQRPGAED 240 NVLNEIVSIL QPTQVPEQEM EVQEPAEPTG VNMLSPGESE HLLEPAEAER SQRRRLLVPA 300 NEGDPTETLR QCFDDFADLV PFDSWEPLMR KLGLMDNEIK VAKAEAAGHR DTLYTMLIKW 360 VNKTGRDASV HTLLDALETL GERLAKQKIE DHLLSSGKFM YLEGNADSAM S 411 Seq ID NO : 284 Protein Sequence Protein Accession # : NP_002002. 2 1 11 21 31 41 51 MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 60 ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 120 LTSSNDDEDP KSHRDLSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 180 TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESWPSDRG TYTCLVENAV GSIRYNYLLD 240 VLERSPHRPI LQAGLPANTT AWGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300 YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA 360 AAPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHGRHP RPPATVQKLS RFPLARQFSL 420 ESGSSGKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 480 WRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 540 TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPVLV SCAYQVARGM 600 QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA 660 LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPHCPPELYG 720 LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS 780 VFSHDPLPLG SSSFPFGSGV QT 802 Seq ID NO : 285 Protein Sequence Protein Accession # : NP 075252. 1 1 11 21 31 41 51 MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 60 ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 120 LTSSNDDEDP KSHRDLSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 180 TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESWPSDRG TYTCLVENAV GSIRYNYLLD 240 VLERSPHRPI LQAGLPANTT AWGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300 YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPGTGRIPHL 360 TCDSLTPAGR TKSPTLQFSL ESGSSGKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW 420 EFPRDRLVLG KPLGEGCFGQ WRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE 480 MEVMKLIGRH KNIINLLGVC TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS 540

EGPLSFPVLV SCAYQVARGM QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI 600 DYYKKTSNGR LPVKWMAPEA LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS 660 LLREGHRMDR PPHCPPELYG LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT 720 FGPYSPSGGD ASSTCSSSDS VFSHDPLPLG SSSFPFGSGV QT 762 Seq ID NO : 286 Protein Sequence Protein Accession # : NP 002836. 2 1 11 21 31 41 51 MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ VNTLTKPTSD 60 PWMPSGSLML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNSP PGLLNVYVKV 120 NNGPLGNPIW NISGDPTRTW NRAELAISTF WPNFYQVIFE VITSGHQGYL AIDEVKVLGH 180 PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR 240 FIASFNVVNT TKRDAGKYRC MIRTEGGVGI SNYAELWKE PPVPIAPPQL ASVGATYLWI 300 QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE 360 GGTGSPGPAL RTRTKCADPM RGPRKLEWE VKSRQITIRW EPFGYNVTRC HSYNLTVHYC 420 YQVGGQEQVR EEVSWDTENS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELIVQTDED 480 LPGAVPTESI QGSTFEEKIF LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS 540 KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT 600 DNTVTVMLKP AHSRGAPVSV YQIWEEERP RRTKKTTEIL KCYPVPIHFQ NASLLNSQYY 660 FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI YFQAASRANG ETKIDCVQVA 720 TKGAATPKPV PEPEKQTDHT VKIAGVIAGI LLFVIIFLGV VLVMKKRKLA KKRKETMSST 780 RQEMTVMVNS MDKSYAEQGT NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY 840 YPDETHTMAS DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900 KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN SDYINGNYID 960 GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL VEVGRVKCCK YWPDDTEIYK 1020 DIKVTLIETE LLAEYVIRTF AVEKRGVHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV 1080 KSKSPPSAGP LWHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT 1140 EEQYVFIHDA ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200 RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT 1260 QHPLPNTVKD FWRLVLDYHC TSWMLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE 1320 EDIISRIFRI YNAARPQDGY RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG 1380 GEGPTWHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF 1440 CYEVALEYLN SG 1452 Seq ID NO : 287 Protein Sequence Protein Accession # : NP 057635. 1 1 11 21 31 41 51 MGFLQLLWA VLASEHRVAG AAEVFGNSSE GLIEFSVGKF RYFELNRPFP EEAILHDISS 60 NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI LRPEQSTCTW YLGTSGIQPV 120 QNMAILLSYS ERDPVPGGCN LEFDLDIDPN IYLEYNFFET TIKFAPANLG YARGVDPPPC 180 DAGTDQDSRW RLQYDVYQYF LPENDLTEEM LLKHLQRMVS VPQVKASALK WTLTANDKT 240 SVSFSSLPGQ GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL 300 FALLGFFICF FGHRFWKTEL FFIGFIIMGF FFYILITRLT PIKYDVNLIL TAVTGSVGGM 360 FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK IFHDDGVFWV TFSCIAILIP 420 WFMGCLRIL NILTCGVIGS YSWLAIDSY WSTSLSYITL NVLKRALNKD FHRAFTNVPF 480 QTNDFIILAV WGMLAVSGIT LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHIPP 540 LRERLYGRLT QIKGLFQKEQ PAGERTPLLL 570 Seq ID NO : 288 Protein Sequence Protein Accession # : NP 003811. 1 1 11 21 31 41 51 MEPPGDWGPP PWRSTPRTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG SECCPKCSPG 60 YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD PAMGLRASRN CSRTENAVCG 120 CSPGHFCIVQ DGDHCAACRA YATSSPGQRV QKGGTESQDT LCQNCPPGTF SPNGTLEECQ 180 HQTKCSWLVT KAGAGTSSSH WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDWKVIVS 240 VQRKRQEAEG EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH 283 Seq ID NO : 289 Protein Sequence Protein Accession # : NP 000943. 1 1 11 21 31 41 51 MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN EIKIFMVNLT 60 MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN TYCSVAFLGV ITYNRFQAVT 120 RPIKTAQANT RKRGISLSLV IWVAIVGAAS YFLILDSTNT VPDSAGSGNV TRCFEHYEKG 180 SVPVLIIHIF IVFSFFLVFL IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV 240 FIICFVPHHV VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 300 RKHLTEKFYS MRSSRKCSRA TTDTVTEVW PFNQIPGNSL KN 342 Seq ID NO : 290 Protein Sequence Protein Accession # : NP 003262. 1 1 11 21 31 41 51 GCLGAIKENK CLLLTFFLLL LLVFLLEATI AILFFAYTDK IDRYAQQDLK KGLHLYGTQG 60 NVGLTNAWSI IQTDFRCCGV SNYTDWFEVY NATRVPDSCC LEFSESCGLH APGTWWKAPC 120 YETVKVWLQE NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA 168 Seq ID NO : 291 Protein Sequence Protein Accession # : NP 005620. 1 1 11 21 31 41 51 MAKKSAENGI YSVSGDEKKG PLIAPGPDGA PAKGDGPVGL GTPGGRLAVP PRETWTRQMD 60

FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 120 INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 180 CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSGGLEVPGA LNWEVTLCLL 240 ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLWLLVRGV LLPGALDGII YYLKPDWSKL 300 GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFWF 360 SILGFMAAEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 420 GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 480 TTLLWQAFWE CWVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNW 540 YYEPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG 600 LHHLEYRAQD ADVRGLTTLT PVSESSKVW VESVM 635 Seq ID NO : 292 Protein Sequence Protein Accession # : NP 037464. 1 1 11 21 31 41 51 MKHVLNLYLL GWLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS 60 RSM 63 Seq ID NO : 293 Protein Sequence Protein Accession # : NP 064527. 1 1 11 21 31 41 51 MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW DRKNNPEPWN 60 RLSPNDQYKF LAVSTDYKKL KKDRPDF 87 Seq ID NO : 294 Protein Sequence Protein Accession 0 : NP 002195. 1 1 11 21 31 41 51 MGPGPSRAPR APRLMLCALA LMVAAGGCW SAFNLDTRFL WKEAGNPGS LFGYSVALHR 60 QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 120 DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 180 HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 240 DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 300 SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 360 LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 420 KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 480 DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 540 GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 600 QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 660 RTSERSGEDA HEALLTLWP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 720 EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 780 GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 840 NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 900 VLTCATGRAH CVWLECPIPD APWTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 960 SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK 1020 RARTRALYEA KRQKAEMKSQ PSETERLTDD Y 1051 Seq ID NO : 295 Protein Sequence Protein Accession # : NP 005492. 1 1 11 21 31 41 51 MGPGPSRAPR APRLMLCALA LMVAAGGCW SAFNLDTRFL WKEAGNPGS LFGYSVALHR 60 QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 120 DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 180 HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 240 DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 300 SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 360 LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 420 KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 480 DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 540 GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 600 QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 660 RTSERSGEDA HEALLTLWP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 720 EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 780 GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 840 NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 900 VLTCATGRAH CVWLECPIPD APWTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 960 SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCDFFK 1020 RTRYYQIMPK YHAVRIREEE RYPPPGSTLP TKKHWVTSWQ TRDQYY 1066 Seq ID NO : 296 Protein Sequence Protein Accession # : NP003777 1 11 21 31 41 51 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 60 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL WGVTMLLAT 120 LLIQYERLQG VQSSGVLIIF WFLC W CAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 180 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 240 WSLKEEDRSQ MWQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 300 KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 360 MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 420 MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 480 MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 540

CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 600 RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAW 660 GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 720 QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 780 VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 840 RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTWWQ 900 KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 960 DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 1020 LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYWD 1080 EVLAPVILML LNSFFNAIST LWIMASTPL FTWILPLAV LYTLVQRFYA ATSRQLKRLE 1140 SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE 1200 FVGNCWLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL ESNIVAVERV 1260 KEYSKTETEA PWWEGSRPP EGWPPRGEVE FRNYSVRYRP GLDLVLRDLS LHVHGGEKVG 1320 IVGRTGAGKS SMTLCLFRIL EAAKGEIRID GLNVADIGLH DLRSQLTIIP QDPILFSGTL 1380 RMNLDPFGSY SEEDIWWALE LSHLHTFVSS QPAGLDFQCS EGGENLSVGQ RQLVCLARAL 1440 LRKSRILVLD EATAAIDLET DNLIQATIRT QFDTCTVLTI AHRLNTIMDY TRVLVLDKGV 1500 VAEFDSPANL IAARGIFYGM ARDAGLA 1527 Seq ID NO : 297 Protein Sequence Protein Accession # : NP 002692. 1 1 11 21 31 41 51 MHFYRLFLGA TRRFLNPEWK GEIDNWCVYV LTSLLPFKIQ SQDIKALQKE LEQFAKLLKQ 60 KRITLGYTQA DVGLTLGVLF GKVFSQTTIC RFEALQLSFK NMCKLRPLLQ KWVEEADNNE 120 NLQEICKAET LVQARKRKRT SIENRVRGNL ENLFLQCPKP TLQQISHIAQ QLGLEKDWR 180 VWFCNRRQKG KRSSSDYAQR EDFEAAGSPF SGGPVSFPLA PGPHFGAPGY GSPHFTALYS 240 SVPFPEGEAF PPVSVTTLGS PLHSN 265 Seq ID NO : 298 Protein Sequence Protein Accession # : NP 005449. 1 1 11 21 31 41 51 1 1 1 1 1 1 MASPRRSGQP GRPPPPPPPP ARLLLLLLLP LLLPLAPGAW GWARGAPRPP PSSPPLSIMG 60 LMPLTKEVAK GSIGRGVLPA VELAIEQIRN ESLLRPYFLD LRLYDTECDN AKGLKAFYDA 120 IKYGPNHLMV FGGVCPSVTS IIAESLQGWN LVQLSFAATT PVLADKKKYP YFFRTVPSDN 180 AVNPAILKLL KHYQWKRVGT LTQDVQRFSE VRNDLTGVLY GEDIEISDTE SFSNDPCTSV 240 KKLKGNDVRI ILGQFDQNMA AKVFCCAYEE NMYGSKYQWI IPGWYEPSWW EQVHTEANSS 300 RCLRKNLLAA MEGYIGVDFE PLSSKQIKTI SGKTPQQYER EYNNKRSGVG PSKFHGYAYD 360 GIWVIAKTLQ RAMETLHASS RHQRIQDFNY TDHTLGRIIL NAMNETNFFG VTGQWFRNG 420 ERMGTIKFTQ FQDSREVKVG EYNAVADTLE IINDTIRFQG SEPPKDKTII LEQLRKISLP 480 LYSILSALTI LGMIMASAFL FFNIKNRNQK LIKMSSPYMN NLIILGGMLS YASIFLFGLD 540 GSFVSEKTFE TLCTVRTWIL TVGYTTAFGA MFAKTWRVHA IFKNVKMKKK IIKDQKLLVI 600 VGGMLLIDLC ILICWQAVDP LRRTVEKYSM EPDPAGRDIS IRPLLEHCEN THMTIWLGIV 660 YAYKGLLMLF GCFLAWETRN VSIPALNDSK YIGMSVYNVG IMCIIGAAVS FLTRDQPNVQ 720 FCIVALVIIF CSTITLCLVF VPKLITLRTN PDAATQNRRF QFTQNQKKED SKTSTSVTSV 780 NQASTSRLEG LQSENHRLRM KITELDKDLE EVTMQLQDTP EKTTYIKQNH YQELNDILNL 840 GNFTESTDGG KAILKNHLDQ NPQLQWNTTE PSRTCKDPIE DINSPEHIQR RLSLQLPILH 900 HAYLPSIGGV DASCVSPCVS PTASPRHRHV PPSFRVMVSG L 941 Seq ID NO : 299 Protein Sequence Protein Accession # : NP 055632 1 11 21 31 41 51 MEAARALRLL LWCGCLALP PLAEPVCPER CDCQHPQHLL CTNRGLRWP KTSSLPSPHD 60 VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP KTFEKLSRLE ELYLGNNLLQ 120 ALAPGTLAPL RKLRILYANG NEISRLSRGS FEGLESLVKL RLDGNALGAL PDAVFAPLGN 180 LLYLHLESNR IRFLGKNAFA QLGKLRFLNL SANELQPSLR HAATFAPLRS LSSLILSANS 240 LQHLGPRIFQ HLPRLGLLSL RGNQLTHLAP EAFWGLEALR ELRLEGNRLS QLPTALLEPL 300 HSLEALDLSG NELSALHPAT FGHLGRLREL SLRNNALSAL SGDIFAASPA LYRLDLDGNG 360 WTCDCRLRGL KRWMGDWHSQ GRLLTVFVQC RHPPALRGKY LDYLDDQQLQ NGSCADPSPS 420 ASLTADRRRQ PLPTAAGEEM TPPAGLAEEL PPQPQLQQQG RFLAGVAWDG AARELVGNRS 480 ALRLSRRGPG LQQPSPSVAA AAGPAPQSLD LHKKPQRGRP TRADPALAEP TPTASPGSAP 540 SPAGDPWQRA TKHRLGTEHQ ERAAQSDGGA GLPPLVSDPC DFNKFILCNL TVEAVGADSA 600 SVRWAVREHR SPRPLGGARF RLLFDRFGQQ PKFHRFVYLP ESSDSATLRE LRGDTPYLVC 660 VEGVLGGRVC PVAPRDHCAG LVTLPEAGSR GGVDYQLLTL ALLTVNALLV LLALAAWASR 720 WLRRKLRARR KGGAPVHVRH MYSTRRPLRS MGTGVSADFS GFQSHRPRTT VCALSEADLI 780 EFPCDRFMDS AGGGAGGSLR REDRLLQRFA D 811 Seq ID NO : 300 Protein Sequence Protein Accession # : NP 001783. 2 1 11 21 31 41 51 MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF 60 SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK 120 LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL 180 VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV 240 DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300 NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360 GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY 420 RISGGDPTGR FAIQTDPNSN DGLVTWKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480 TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 540 ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600 NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660 FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720

GTGAIIAILL CIIILLILVL MFWWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780 EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840 KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900 YGGGDD 906 Seq ID NO : 301 Protein Sequence Protein Accession # : NP 058637. 1 1 11 21 31 41 51 MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC SARLPCRLFF 60 RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD LPLPDGLLQV PFRDAWPGTF 120 SFIIETWREE LGDQIGGPAW SLLARVAGRR RLAAGGPWAR DIQRAGAWEL RFSYRARCEP 180 PAVGTACTRL CRPRSAPSRC GPGLRPCAPL EDECEAPLVC RAGCSPEHGF CEQPGECRCL 240 EGWTGPLCTV PVSTSSCLSP RGPSSATTGC LVPGPGPCDG NPCANGGSCS ETPRSFECTC 300 PRGFYGLRCE VSGVTCADGP CFNGGLCVGG ADPDSAYICH CPPGFQGSNC EKRVDRCSLQ 360 PCRNGGLCLD LGHALRCRCR AGFAGPRCEH DLDDCAGRAC ANGGTCVEGG GAHRCSCALG 420 FGGRDCRERA DPCAARPCAH GGRCYAHFSG LVCACAPGYM GARCEFPVHP DGASALPAAP 480 PGLRPGDPQR YLLPPALGLL VAAGVAGAAL LLVHVRRRGH SQDAGSRLLA GTPEPSVHAL 540 PDALNNLRTQ EGSGDGPSSS VDWNRPEDVD PQGIYVISAP SIYAREVATP LFPPLHTGRA 600 GQRQHLLFPY PSSILSVK 618 Seq ID NO : 302 Protein Sequence Protein Accession # : fgenes prediction 1 11 21 31 41 51 MCQAFLWVLG TLWLLKNARC LQPYPPEHAQ SCLISEAKQG QAQLPLGWVK WPLHLRSSLS 60 KRLERKYPSL LNGEIEAQIC KTSSLELPSC DLVTADGSTE VTISENLPAV GFHICQQQDS 120 HVEGMVNISK ASSGQM 136 Seq ID NO : 303 Protein Sequence Protein Accession # : NP079088. 1 1 11 21 31 41 51 1 1 1 1 1 1 MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDAPPSAA APDSGPEAGG LHSGMLEDGL 60 PSNGVPRSTA PGGIPNPEKK TNCETQCPNP QSLSSGPLTQ KQNGLQTTEA KRDAKRMPAK 120 EVTINVTDSI QQMDRSRRIT KNCVN 145 Seq ID NO : 304 Protein Sequence Protein Accession # : XP040550. 1 1 11 21 31 41 51 I I I I I I MGADGETWL KNMLIGINLI LLGSMIKPSE CQLEVTTERV QRQSVEEEGG IANYNTSSKE 60 QPWFNHVYN INVPLDNLCS SGLEASAEQE VSAEDETLAE YMGQTSDHES QVTFTHRINF 120 PKKACPCASS AQVLQELLSR IEMLEREVSV LRDQCNANCC QESAATGQLD YIPHCSGHGN 180 FSFESCGCIC NEGWFGKNCS EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS 240 SRGLCVDGEC VCEEPYTGED CRELRCPGDC SGKGRCANGT CLCEEGYVGE DCGQRQCLNA 300 CSGRGQCEEG LCVCEEGYQG PDCSAVAPPE DLRVAGISDR SIELEWDGPM AVTEYVISYQ 360 PTALGGLQLQ QRVPGDWSGV TITELEPGLT YNISVYAVIS NILSLPITAK VATHLSTPQG 420 LQFKTITETT VEVQWEPFSF SFDGWEISFI PKNNEGGVIA QVPSDVTSFN QTGLKPGEEY 480 IVNWALKEQ ARSPPTSASV STVIDGPTQI LVRDVSDTVA FVEWIPPRAK VDFILLKYGL 540 VGGEGGRTTF RLQPPLSQYS VQALRPGSRY EVSVSAVRGT NESDSATTQF TTEIDAPKNL 600 RVGSRTATSL DLEWDNSEAE VQEYKVVYST LAGEQYHEVL VPRGIGPTTR ATLTDLVPGT 660 EYGVGISAVM NSQQSVPATM NARTELDSPR DLMVTASSET SISLIWTKAS GPIDHYRITF 720 TPSSGIASEV TVPKDRTSYT LTDLEPGAEY IISVTAERGR QQSLESTVDA FTGFRPISHL 780 HFSHVTSSSV NITWSDPSPP ADRLILNYSP RDEEEEMMEV SLDATKRHAV LMGLQPATEY 840 IVNLVAVHGT VTSEPIVGSI TTGIDPPKDI TISNVTKDSV MVSWSPPVAS FDYYRVSYRP 900 TQVGRLDSSV VPNTVTEFTI TRLNPATEYE ISLNSVRGRE ESERICTLVH TAMDNPVDLI 960 ATNITPTEAL LQWKAPVGEV ENYVIVLTHF AVAGETILVD GVSEEFRLVD LLPSTHYTAT 1020 MYATNGPLTS GTISTNFSTL LDPPANLTAS EVTRQSALIS WQPPRAEIEN YVLTYKSTDG 1080 SRKELIVDAE DTWIRLEGLL ENTDYTVLLQ AAQDTTWSSI TSTAFTTGGR VFPHPQDCAQ 1140 HLMNGDTLSG VYPIFLNGEL SQKLQVYCDM TTDGGGWIVF QRRQNGQTDF FRKWADYRVG 1200 FGNVEDEFWL GLDNIHRITS QGRYELRVDM RDGQEAAFAS YDRFSVEDSR NLYKLRIGSY 1260 NGTAGDSLSY HQGRPFSTED RDNDVAVTNC AMSYKGAWWY KNCHRTNLNG KYGESRHSQG 1320 INWYHWKGHE FSIPFVEMKM RPYNHRLMAG RKRQSLQF 1358 Seq ID NO : 305 Protein Sequence Protein Accession # : NP005874. 1 1 11 21 31 41 51 MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL KHLQGKLEQE 60 ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP AARTPEGSPV HGSGPSKDSF 120 GELSRATIRL LEELDRERCF LLNEIEKEEK EKLWYYSQLQ GLSKRLDELP HVETQFSMQM 180 DLIRQQLEFE AQHIRSLMEE RFGTSDEMVQ RAQIRASRLE QIDKELLEAQ DRVQQTEPQA 240 LLAVKSVPVD EDPETEVPTH PEDGTPQPGN SKVEWFWLL SMLATRDQED TARTLLAMSS 300 SPESCVAMRR SGCLPLLLQI LHGTEAAAGG RAGAPGAPGA KDARMRANAA LHNIVFSQPD 360 QGLARKEMRV LHVLEQIRAY CETCWDWLQA RDGGPEGGGA GSAPIPIEPQ ICQATCAVMK 420 LSFDEEYRRA MNELGGLQAV AELLQVDYEM HKMTRDPLNL ALRRYAGMTL TNLTFGDVAN 480 KATLCARRGC MEAIVAQLAS DSEELHQWS SILRNLSWRA DINSKKVLRE AGSVTALVQC 540 VLRATKESTL KSVLSALWNL SAHSTENKAA ICQVDGALGF LVSTLTYKCQ SNSLAIIESG 600 GGILRNVSSL VATREDYRQV LRDHNCLQTL LQHLTSHSLT IVSNACGTLW NLSARSARDQ 660 ELLWDLGAVG MLRNLVHSKH KMIAMGSAAA LRNLLAHRPA KHQAAATAVS PGSCVPSLYV 720 RKQRALEAEL DARHLAQALE HLEKQGPPAA EAATKKPLPP LRHLDGLAQD YASDSGCFDD 780 DDAPSSLAAA AATGEPASPA ALSLFLGSPF LQGQALARTP PTRRGGKEAE KDTSGEAAVA 840 AKAKAKLALA VARIDQLVED ISALHTSSDD SFSLSSGDPG QEAPREGRAQ SCSPCRGPEG 900

GRREAGSRAH PLLRLKAAHA SLSNDSLNSG SASDGYCPRE HMLPCPLAAL ASRREDPRCG 960 QPRPSRLDLD LPGCQAEPPA REATSADARV RTIKLSPTYQ HVPLLEGASR AGAEPLAGPG 1020 ISPGARKQAW LPADHLSKVP EKLAAAPLSV ASKALQKLAA QEGPLSLSRC SSLSSLSSAG 1080 RPGPSEGGDL DDSDSSLEGL EEAGPSEAEL DSTWRAPGAT SLPVAIPAPR RNRGRGLGVE 1140 DATPSSSSEN YVQETPLVLS RCSSVSSLGS FESPSIASSI PSEPCSGQGS GTISPSELPD 1200 SPGQTMPPSR SKTPPLAPAP QGPPEATQFS LQWESYVKRF LDIADCRERC RLPSELDAGS 1260 VRFTVEKPDE NFSCASSLSA LALHEHYVQQ DVELRLLPSA CPERGGGAGG AGLHFAGHRR 1320 REEGPAPTGS RPRGAADQEL ELLRECLGAA VPARLRKVAS ALVPGRRALP VPVYMLVPAP 1380 APAQEDDSCT DSAEGTPVNF SSAASLSDET LQGPPRDQPG GPAGRQRPTG RPTSARQAMG 1440 HRHKAGGAGR SAEQSRGAGK NRAGLELPLG RPPSAPADKD GSKPGRTRGD GALQSLCLTT 1500 PTEEAVYCFY GNDSDEEPPA AAPTPTHRRT SAIPRAFTRE RPQGRKEAPA PSKAAPAAPP 1560 PARTQPSLIA DETPPCYSLS SSASSLSEPE PSEPPAVHPR GREPAVTKDP GPGGGRDSSP 1620 SPRAAEELLQ RCISSALPRR RPPVSGLRRR KPRATRLDER PAEGSRERGE EAAGSDRASD 1680 LDSVEWRAIQ EGANSIVTWL HQAAAATREA SSESDSILSF VSGLSVGSTL QPPKHRKGRQ 1740 AEGEMGSARR PEKRGAASVK TSGSPRSPAG PEKPRGTQKT TPGVPAVLRG RTVIYVPSPA 1800 PRAQPKGTPG PRATPRKVAP PCLAQPAAPA KVPSPGQQRS RSLHRPAKTS ELATLSQPPR 1860 SATPPARLAK TPSSSSSQTS PASQPLPRKR PPVTQAAGAL PGPGASPVPK TPARTLLAKQ 1920 HKTQRSPVRI PFMQRPARRG PPPLARAVPE PGPRGRAGTE AGPGARGGRL GLVRVASALS 1980 SGSESSDRSG FRRQLTFIKE SPGLRRRRSE LSSAESAASA PQGASPRRGR PALPAVFLCS 2040 SRCEELRAAP RQGPAPARQR PPAARPSPGE RPARRTTSES PSRLPVRAPA ARPETVKRYA 2100 SLPHISVARR PDGAVPAAPA SADAARRSSD GEPRPLPRVA APGTTWRRIR DEDVPHILRS 2160 TLPATALPLR GSTPEDAPAG PPPRKTSDAV VQTEEVAAPK TNSSTSPSLE TREPPGAPAG 2220 GQLSLLGSDV DGPSLAKAPI SAPFVHEGLG VAVGGFPASR HGSPSRSARV PPFNYVPSPM 2280 WAATTDSAA EKAPATASAT LLE 2303 Seq ID NO : 306 Protein Sequence Protein Accession # : NP 006356. 1 1 11 21 31 41 51 1 1 1 1 1 1 MFLTEDLITF NLRNFLLFQL WESSFSPGAG GFCTTLPPSF LRVDDRATSS TTDSSRAPSS 60 PRPPGSTSHC GISTRCTERC LCVLPLRTSQ VPDVMAPQHD QEKFHDLAYS CLGKSFSMSN 120 QDLYGYSTSS LALGLAWLSW ETKKKNVLHL VGLDSL 156 Seq ID NO : 307 Protein Sequence Protein Accession # : AAH32726. 1 1 11 21 31 41 51 ( MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSSSGPK GNGLIPSPAH SAHCSFYRTR 60 TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISSDRFRSFD ALLIELTRSL SDNVNLPQGV 120 RTIYTIDGSR KVTSLDELLE GESYVCASNE PFRKVDYTKN INPNWSVNIK GGTSRALAAA 180 SSVKSEVKES KDFIKPKLVT VIRSGVKPRK AVRILLNKKT AHSFEQVLTD ITEAIKLDSG 240 WKRLCTLDG KQVTCLQDFF GDDDVFIACG PEKFRYAQDD FVLDHSECRV LKSSYSRSSA 300 VKYSGSKSPG PSRRSKSPAS VNGTPSSQLS TPKSTKSSSS SPTSPGSFRG LKISAHGRSS 360 SNVNGGPELD RCISPEGVNG NRCSESSTLL EKYKIGKVIG DGNFAWKEC IDRSTGKEFA 420 LKIIDKAKCC GKEHLIENEV SILRRVKHPN IIMLVEEMET ATELFLVMEL VKGGDLFDAI 480 TSSTKYTERD GSAMVYNLAN ALRYLHGLSI VHRDIKPENL LVCEYPDGTK SLKLGDFGLA 540 TWEGPLYTV CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RSENNLQEDL 600 FDQILAGKLE FPAPYWDNIT DSAKELISQM LQVNVEARCT AGQILSHPWV SDDASQENNM 660 QAEVTGKLKQ HFNNALPKQN STTTGVSVIM FDLTV 695 Seq ID NO : 308 Protein Sequence Protein Accession # : NP 055978. 2 1 11 21 31 41 51 MEEMEEELKC PVCGSFYREP IILPCSHNLC QACAR. NILVQ TPESESPQSH RAAGSGVSDY 60 DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR VFPPAMPPPA THLSPALAPV 120 PRNSCITCPQ CHRSLILDDR GLRGFPKNRV LEGVIDRYQQ SKAAALKCQL CEKAPKEATV 180 MCEQCDVFYC DPCRLRCHPP RGPLAKHRLV PPAQGRVSRR LSPRKVSTCT DHELENHSMY 240 CVQCKMPVCY QCLEEGKHSS HEVKALGAMW KLHKSQLSQA LNGLSDRAKE AKEFLVQLRN 300 MVQQIQENSV EFEACLVAQC DALIDALNRR KAQLLARVNK EHEHKLKVVR DOISHCTVKL 360 RQTTGLMEYC LEVIKENDPS GFLQISDALI RRVHLTEDQW GKGTLTPRMT TDFDLSLDNS 420 PLLQSIHQLD FVQVKASSPV PATPILQLEE CCTHNNSATL SWKQPPLSTV PADGYILELD 480 DGNGGQFREV YVGKETMCTV DGLHFNSTYN ARVKAFNKTG VSPYSKTLVL QTSEVAWFAF 540 DPGSAHSDII LSNDNLTVTC SSYDDRWLG KTGFSKGIHY WELTVDRYDN HPDPAFGVAR 600 MDVMKDVMLG KDDKAWAMYV DNNRSWFMHN NSHTNRTEGG ITKGATIGVL LDLNRKNLTF 660 FINDEQQGPI AFDNVEGLFF PAVSLNRNVQ VTLHTGLPVP DFYSSRASIA 710 Seq ID NO : 309 Protein Sequence Protein Accession # : NP 116025. 1 1 11 21 31 41 51 ( MEDLEEDVRF IVDETLDFGG LSPSDSREEE DITVLVTPEK PLRRGLSHRS DPNAVAPAPQ 60 GVRLSLGPLS PEKLEEILDE ANRLAAQLEQ CALQDRESAG EGLGPRRVKP SPRRETFVLK 120 DSPVRDLLPT VNSLTRSTPS PSSLTPRLRS NDRKGSVRAL RATSGKRPSN MKRESPTCNL 180 FPASKSPASS PLTRSTPPVR GRAGPSGRAA ASPPTPIRSV LAPQPSTSNS QRLPRPQGAA 240 AKSSSQLPIP SAIPRPASRM PLTSRSVPPG RGALPPDSLS TRKGLPRPST AGHRVRESGH 300 KVPVSQRLNL PVMGATRSNL QPPRKVAVPG PTR 333 Seq ID NO : 310 Protein Sequence Protein Accession # : ref|XP_166946. 2 1 11 21 31 41 51 MGSDSRLPEM EEKGSGDKAG WSGALLAEVK NQGLKLCEWM LVLKAELVEW YTSVIVGQQG 60 HRLKMDLLKE RHHRKYLQKP IKRCSGLMGL NWSLRPAISS SPLARSQEKH HGAKGNEGVK 120

ALSFRKLRKL KRPPTPPSQA KSWRGRTGSA ADSPGAAAMA VQAALLSTHP FVPFGFGGSP 180 DGLGGAFGAL DKGCCFEDDE TGAPAGALLS GAEGGDVREA TRDLLSFIDS ASSNIKLALD 240 KPGKSKRKVN HRNAPTVAAP AHGKAAPRRE ASQAAAAASL QSRSLAALFD SLRHVPGGAE 300 PAGGEVAAPA AGLGGAGTGG AGGDVAGPAG ATAIPGARKV PLRARNLPPS FFTEPSRAGG 360 GGCGPSGPDV SLGDLEKGAE AVEFFELLGP DYGAGTEAAV LLAAEPLDVF PAGASVLRGP 420 PELEPGLFEP PPAWGNLLY PEPWSVPGCS PTKKSPLTAP RGGLTLNEPL SPLYPAAADS 480 PGGEDGRGHL ASFAPFFPDC ALPPPPPPHQ VSYDYSAGYS RTAYSSLWRS DGVWEGAPGE 540 EGAHRD 546 Seq ID NO : 311 Protein Sequence Protein Accession # : NP 071406. 1 1 11 21 31 41 51 MAPTKPSFQQ DPSRRERLQA LRKEKSRDAA RSRRGKENFE FYELAKLLPL PAAITSQLDK 60 ASIIRLTISY LKMRDFANQG DPPWNLRMEG PPPNTSVKGA QRRRSPSALA IEVFEAHLGS 120 HILQSLDGFV FALNQEGKFL YISETVSIYL GLSQVELTGS SVFDYVHPGD HVEMAEQLGM 180 KLPPGRGLLS QGTAEDGASS ASSSSQSETP EPVESTSPSL LTTDNTLERS FFIRMKSTLT 240 KRGVHIKSSG YKVIHITGRL RLRVSLSHGR TVPSQIMGLV WAHALPPPT INEVRIDCHM 300 FVTRVNMDLN IIYCENRISD YMDLTPVDIV GKRCYHFIHA EDVEGIRHSH LDLLNKGQCV 360 TKYYRWMQKN GGYIWIQSSA TIAINAKNAN EKNIIWVNYL LSNPEYKDTP MDIAQLPHLP 420 EKTSESSETS DSESDSKDTS GITEDNENSK SDEKGNQSEN SEDPEPDRKK SGNACDNDMN 480 CNDDGHSSSN PDSRDSDDSF EHSDFENPKA GEDGFGALGA MQIKVERYVE SESDLRLQNC 540 ESLTSDSAKD SDSAGEAGAQ ASSKHQKRKK RRKRQKGGSA SRRRLSSASS PGGLDAGLVE 600 PPRLLSSPNS ASVLKIKTEI SEPINFDNDS SIWNYPPNRE ISRNESPYSM TKPPSSEHFP 660 SPQGGGGGGG GGGGLHVAIP DSVLTPPGAD GAAARKTQFG ASATAALAPV ASDPLSPPLS 720 ASPRDKHPGN GGGGGGGGGG AGGGGPSASN SLLYTGDLEA LQRLQAGNW LPLVHRVTGT 780 LAATSTAAQR VYTTGTIRYA PAEVTLAMQS NLLPNAHAVN FVDVNSPGFG LDPKTPMEML 840 YHHVHRLNMS GPFGGAVSAA SLTQMPAGNV FTTAEGLFST LPFPVYSNGI HAAQTLERKE 900 D 901 Seq ID NO : 312 Protein Sequence Protein Accession # : NP 005797. 1 1 11 21 31 41 51 MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE LSAELRGAMG 60 SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ MTEPELQQLR LKINSRERKR 120 MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH 180 HAGFHPSACG GLAHSAPLPA ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS 240 ASLPGSGLPS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV 300 PPPHHHVSAM GAGSLPRLTS DAK 323 Seq ID NO : 313 Protein Sequence Protein Accession # : XP 045127. 3 1 11 21 31 41 51 MTVLEESSIS LMSSWADFS EFEEDPQVFN TLFPSRPIVP LSSRSMEISE TSVGISAEVD 60 MSSVTTTQVP PAHGRLSVPA SLDPTAGSLS VAETQVTPSS VTTAFFSVIT SILLDSSFSV 120 IANKNTPSLA VRDPSVFTPY SLVPSVESSL FSDQERSSFS EHKPRGALDF ASSFFSTPPL 180 ELSGSISSPS EAPASLSLMP SDLSPFTSQS FSPLVETFTL FDSSDLQSSQ LSLPSSTNLE 240 FSQLQPSSEL PLNTIMLLPS RSEVSPWSSF PSDSLEFVEA STVSLTDSEA HFTSAFIETT 300 SYLESSLISH ESAVTALVPP GSESFDILTA GIQATSPLTT VHTTPILTES SLFSTLTPPD 360 DQISALDGHV SVLASFSKAI PTGTVLITDA YLPSGSSFVS EATPFPLPTE LTWGPSLTP 420 TEVPLNTSTE VSTTSTGAAT GGPLDSTLMG DAASQSPPES SAAPPLPSLR PVTAFTLEAT 480 VDTPTLATAK PPYVCDITVP DAYLITTVLA RRAVQEYIIT AIKEVLRIHF NRAVELKVYE 540 LFTDFTFLVT SGPFVYTAIS VINVLINSKL VRDQTPLILS VKPSFLVPES RFQVQTVLQF 600 VPPSVDTGFC NFTQRIEKGL MTALFEVRKH HQGTYNLTVQ ILNITISSSR VTPRRGPVNI 660 IFAVKSTQGF LNGSEVSELL RNLSWEFSF YLGYPVLQIA EPFQYPQLNL SQLLKSSWVR 720 TVLLGVMEKQ LQNEVFQAEM ERKLAQLLSE VSTRRRMWRR ATVAAGNSW QWNVSRLEG 780 DDNPVQLIYF VEDQDGERLS AVKSSDLINK MDLQRAAIIL GYRIQGVIAQ PVDRVKRPSP 840 ESQSNNLWVI VGWIPVLW MVIWILYWK LCRTDKLDFQ PDTVANIQQR QKLQIPSVKG 900 FDFAKQHLGQ HNKDDILIIH EPAPLPGPLK DHTTPSENGD VPSPKSKIPS KNVRHRGRVS 960 PSDADSTVSE ESSERDAGDK TPGAVNDGRS HRAPQSGPPL PSSGNEQHSS ASIFEHVDRI 1020 SRPPEASRRV PSKIQLIAMQ PIPAPPVQRP SPADRVAESN KINKEIQTAL RHKSEIEHHR 1080 NKIRLRAKRR GHYEFPVWD LSSGDTKERH RVYRRAQMQI DKILDPTASV PSVFIEPRKS 1140 SRIKRSPKPR RKHQVNGCPA DAEKDRLITT DSDGTYRRPP GVHNSAYIGC PSDPDLPADV 1200 QTPSSVELGR YPALPFPASQ YIPPQPSIEE ARQTMHSLLD DAFALVAPSS QPASTAGVGP 1260 GVPPGLPANS TPSQEERRAT QWGSFYSPAQ TANNPCSRYE DYGMTPPTGP LPRPGFGPGL 1320 LQSTELVPPD PQQPQASAEA PFAARGIYSE EMPSVARPRP VGGTTGSQIQ HLTQVGIASR 1380 IGAQPVEIPP SRGSQYGGPG WPSYGEDEAG RREAVPRTSG REPSAPSGNL PHRGLQGPGL 1440 GYPTSSTEDL QPGHSSASLI KAIREELLRL SQKQSTVQNF HS 1482 Seq ID NO : 314 Protein Sequence Protein Accession # : BAC04820. 1 1 11 21 31 41 51 MAPRPLGPLV LALGGAAAVL GSVLFILWKT YFGRGRERRW DRGEAWWGAE AARLPEWDEW 60 DPEDEEDEEP ALEELEQREV LVLGLDGAGK STFLRVLSGK PPLEGHIPTW GFNSVRLPTK 120 DFEVDLLEIG GSQNLRFYWK EFVSEVDVLV FWDSADRLR LPWARQELHK LLDKDPDLPV 180 VWANKQDLS EAMSMGELQR ELGLQAIDNQ REVFLLAASI APAGPTFEEP GTVHIWKLLL 240 ELLS 244 Seq ID NO : 315 Protein Sequence Protein Accession # : Nu 066563. 1 1 11 21 31 41 51

I I I I I I MARRAGGARM FGSLLLFALL AAGVAPLSWD LPEPRSRASK IRVHSRGNLW ATGHFMGKKS 60 LEPSSPSHWG QLPTPPLRDQ RLQLSHDLLG ILLLKKALGV SLSRPAPQIQ YRRLLVQILQ 120 K 121 Seq ID NO : 316 Protein Sequence Protein Accession # : NP 002046. 1 1 11 21 31 41 51 MERRRITSAA RRSYVSSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA 60 GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL 120 RELRLRLDQL TANSARLEVE RDNLAQDLAT VRQKLQDETN LRLEAENNLA AYRQEADEAT 180 LARLDLERKI ESLEEEIRFL RKIHEEEVRE LQEQLARQQV HVELDVAKPD LTAALKEIRT 240 QYEAMASSNM HEAEEWYRSK FADLTDAAAR NAELLRQAKH EANDYRRQLQ SLTCDLESLR 300 GTNESLERQM REQEERHVRE AASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNVKLALD 360 IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIW KTVEMRDGEV 420 IKESKQEHKD VM 432 Seq ID NO : 317 Protein Sequence Protein Accession # : AAA19191. 1 1 11 21 31 41 51 MRLLSSLSGS SVSSDAEEYQ PPIWKSYLYQ LQQEAPRPKR IICPREVENR PKYYGREFHG 60 IISREQADEL LGGVEGAYIL RESQRQPGCY TLALRFGNQT LNYRLFHDGK HFVGEKRFES 120 IHDLVTDGLI TLYIETKAAE YISKMTTNPI YEHIGYATLL REKVSRRLSR SKNEPRKTNV 180 THEEHTAVEK ISSLVRRAAL THNDNHFNYE KTHNFKVHTF RGPHWCEYCA NFMWGLIAQG 240 VRCSDCGLNV HKQCSKHVPN DCQPDLKRIK KVYCCDLTTL VKAHNTQRPM WDICIREIE 300 ARGLKSEGLY RVSGFTEHIE DVKMAFDRDG EKADISANVY PDINIITGAL KLYFRDLPIP 360 VITYDTYSKF IDAAKISNAD ERLEAVHEVL MLLPPAHYET LRYLMIHLKK VTMNEKDNFM 420 NAENLGIVFG PTLMRPPEDS TLTTLHDMRY QKLIVQILIE NEDVLF 466 Seq ID NO : 318 Protein Sequence Protein Accession # : XP 113553. 1 1 11 21 31 41 51 1 1 1 1 1 1 MKRAHPEYSS SDSELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR KRRRGIIEKR 60 RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH LKMLHTAGGK GYFDAHALAM 120 DYRSLGFREC LAEVARYLSI IEGLDASDPL RVRLVSHLNN YASQREAASG AHAGLGHIPW 180 GTVFGHHPHI AHPLLLPQNG HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSLGPV 240 LPWTSASKL SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE 300 IGAF 304 Seq ID NO : 319 Protein Sequence Protein Accession # : NP 001927. 2 1 11 21 31 41 51 MTTAKEPSAS GKSVQQQEQE LVGSNPPQRN WKGIAIALLV ILVICSLIVT SVILLTPAED 60 NSLSQKKKVT VEDLFSEDFK IHDPEAKWIS DTEFIYREQK GTVRLWNVET NTSTVLIEGK 120 KIESLRAIRY EISPDREYAL FSYNVEPIYQ HSYTGYYVLS KIPHGDPQSL DPPEVSNAKL 180 QYAGWGPKGQ QLIFIFENNI YYCAHVGKQA IRWSTGKEG VIYNGLSDWL YEEEILKTHI 240 AHWWSPDGTR LAYAAINDSR VPIMELPTYT GSIYPTVKPY HYPKAGSENP SISLHVIGLN 300 GPTHDLEMMP PDDPRMREYY ITMVKWATST KVAVTWLNRA QNVSILTLCD ATTGVCTKKH 360 EDESEAWLHR QNEEPVFSKD GRKFFFIRAI PQGGRGKFYH ITVSSSQPNS SNDNIQSITS 420 GDWDVTKILA YDEKGNKIYF LSTEDLPRRR QLYSANTVGN FNRQCLSCDL VENCTYFSAS 480 FSHSMDFFLL KCEGPGVPMV TVHNTTDKKK MFDLETNEHV KKAINDRQMP KVEYRDIEID 540 DYNLPMQILK PATFTDTTHY PLLLWDGTP GSQSVAEKFE VSWETVMVSS HGAVWKCDG 600 RGSGFQGTKL LHEVRRRLGL LEEKDQMEAV RTMLKEQYID RTRVAVFGKD YGGYLSTYIL 660 PAKGENQGQT FTCGSALSPI TDFKLYASAF SERYLGLHGL DNRAYEMTKV AHRVSALEEQ 720 QFLIIHPTAD EKIHFQHTAE LITQLIRGKA NYSLQIYPDE SHYFTSSSLK QHLYRSIINF 780 FVECFRIQDK LPTVTAKEDE EED 803 Seq ID NO : 320 Protein Sequence Protein Accession # : XP 087461. 1 1 11 21 31 41 51 MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SAASPSPRGC WPRRPPGPPS 60 ARARRRRRRR RRLCNISVQR QMLSSLLVRW GRPRGFQCDL LLFSTNAHGR AFFAAAFHRV 120 GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR GRRTGRLRPA AAPSAAAATA GAPTALPAYP 180 AAEPPGPLWL QGEPLHFCCL DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIWWSVAA 240 LIWPVPIIAG FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AVTSGVATK 299 Seq ID NO : 321 Protein Sequence Protein Accession # : NP 036393. 1 1 11 21 31 41 51 MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFW RENGTTCLMA 60 EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVKGRCG HSQSELQVFW VDRAYALKML 120 FVKESHNMSK GPEATWRLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY 180 ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI 240 LGLILGLVIM VTLAIYHVHH KMTANQVQIP RDRSQYKHMG 280 Seq ID NO : 322 Protein Sequence Protein Accession # : NP 653187 1 11 21 31 41 51

I I I I I I MWVLGIAATF CGLFLLPGFA LQIQCYQCEE FQLNNDCSSP EFIVNCTVNV QDMCQKEVME 60 QSAGIMYRKS CASSAACLIA SAGYQSFCSP GKLNSVCISC CNTPLCNGPR PKKRGSSASA 120 LRPGLRTTIL FLKLALFSAH C 141 Seq ID NO : 323 Protein Sequence Protein Accession # : NP 004685 1 11 21 31 41 51 MTQNKLKLCS KANVYTEVPD GGwGWAVAVS FFFVEVFTYG IIKTFGVFFN DLMDSFNESN 60 SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLWMLGGLL VSTGMVAASF SQEVSHMYVA 120 IGIISGLGYC FSFLPTVTIL SQYFGKRRSI VTAVASTGEC FAVFAFAPAI MALKERIGWR 180 YSLLFVGLLQ LNIVIFGALL RPIIIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS 240 GVELTTSPKN VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF 300 GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV LNREPIRKIY 360 IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG GLTFHCLLKM MSWALQKMSS 420 AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ 480 RHHSGETKW SHRGKTLQDI PEDFLEMDLA KNEHRVHVQM EPV 523 Seq ID NO : 324 Protein Sequence Protein Accession # : NP 004824. 1 1 11 21 31 41 51 MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS 60 AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK 120 QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT 180 VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL 240 NIIRKAGETP KINTLQTQPL GTIVNGLFW QKVTEKKKNI LFDLSDNTGK MEVLGVRNED 300 TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT 343 Seq ID NO : 325 Protein Sequence Protein Accession # : NP 005400. 1 1 11 21 31 41 51 MSVKGMAIAL AVILCATWQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI 60 EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF 94 Seq ID NO : 326 Protein Sequence Protein Accession # : NP 002553. 1 1 11 21 31 41 51 MPACCSCSDV FQYETNKVTR IQSMNYGTIK WFFHVIIFSY VCFALVSDKL YQRKEPVISS 60 VHTKVKGIAE VKEEIVENGV KKLVHSVFDT ADYTFPLQGN SFFVMTNFLK TEGQEQRLCP 120 EYPTRRTLCS SDRGCKKGWM DPQSKGIQTG RCVVHEGNQK TCEVSAWCPI EAVEEAPRPA 180 LLNSAENFTV LIKNNIDFPG HNYTTRNILP GLNITCTFHK TQNPQCPIFR LGDIFRETGD 240 NFSDVAIQGG IMGIEIYWDC NLDRWFHHCH PKYSFRRLDD KTTNVSLYPG YNFRYAKYYK 300 ENNVEKRTLI KVFGIRFDIL VFGTGGKFDI IQLWYIGST LSYFGLAAVF IDFLIDTYSS 360 NCCRSHIYPW CKCCQPCWN EYYYRKKCES IVEPKPTLKY VSFVDESHIR MVNQQLLGRS 420 LQDVKGQEVP RPAMDFTDLS RLPLALHDTP PIPGQPEEIQ LLRKEATPRS RDSPVWCQCG 480 SCLPSQLPES HRCLEELCCR KKPGACITTS ELFRKLVLSR RVLQFLLLYQ EPLLALDVDS 540 TNSRLRHCAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKSEGQYSG FKSPY 595 Seq ID NO : 327 Protein Sequence Protein Accession # : NP 001784. 2 1 11 21 31 41 51 MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA LGKVFMGCPG 60 QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR ILRRHKRDWV VAPISVPENG 120 KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA DSPPEGVFAV EKETGWLLLN KPLDREEIAK 180 YELFGHAVSE NGASVEDPMN ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT 240 DEDDAIYTYN GWAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA 300 TDMDGDGSTT TAVAWEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT VTDLDAPNSP 360 AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA KNQHTLYVEV TNEAPFVLKL 420 PTSTATIWH VEDVNEAPVF VPPSKWEVQ EGIPTGEPVC VYTAEDPDKE NQKISYRILR 480 DPAGWLAMDP DSGQVTAVGT LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID 540 VNDHGPVPEP RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD 600 TWLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP WKGGFILPVL 660 GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY YGEEGGGEED QDYDITQLHR 720 GLEARPEWL RNDVAPTIIP TPMYRPRPAN PDEIGNFIIE NLKAANTDPT APPYDTLLVF 780 DYEGSGSDAA SLSSLTSSAS DQDQDYDYLN EWGSRFKKLA DMYGGGEDD 829 Seq ID NO : 328 Protein Sequence Protein Accession # : NP 002562. 1 1 11 21 31 41 51 1 1 1 1 1 1 MDIPQTKQDL ELPKLAGTWH SMAMATNNIS LMATLKAPLR VHITSLLPTP EDNLEIVLHR 60 WENNSCVEKK VLGEKTGNPK KFKINYTVAN EATLLDTDYD NFLFLCLQDT TTPIQSMMCQ 120 YLARVLVEDD EIMQGFIRAF RPLPRHLWYL LDLKQMEEPC RF 162 Seq ID NO : 329 Protein Sequence LEK6 Protein Accession # : NP 001318. 1 1 11 21 31 41 51 MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA 60

PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG 120 VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR 180 Seq ID NO : 330 Protein Sequence LEK6 Protein Accession # : NP 066274 1 11 21 31 41 51 MQAEGQGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 60 PRGPHGGAAS AQDGRCPCGA RRPDSRLLQF RLTAADHRQL QLSISSCLQQ LSLLMWITQC 120 FLPVFLAQAP SGQRR 135 Seq ID NO : 331 Protein Sequence Protein Accession # : NP 008859. 1 1 11 21 31 41 51 1 1 1 1 1 1 MDLVLKRCLL HLAVIGALLA VGATKVPRNQ DWLGVSRQLR TKAWNRQLYP EWTEAQRLDC 60 WRGGQVSLKV SNDGPTLIGA NASFSIALNF PGSQKVLPDG QVIWVNNTII NGSQVWGGQP 120 VYPQETDDAC IFPDGGPCPS GSWSQKRSFV YVWKTWGQYW QVLGGPVSGL SIGTGRAMLG 180 THTMEVTVYH RRGSRSYVPL AHSSSAFTIT DQVPFSVSVS QLRALDGGNK HFLRNQPLTF 240 ALQLHDPSGY LAEADLSYTW DFGDSSGTLI SRALWTHTY LEPGPVTAQV VLQAAIPLTS 300 CGSSPVPGTT DGHRPTAEAP NTTAGQVPTT EWGTTPGQA PTAEPSGTTS VQVPTTEVIS 360 TAPVQMPTAE STGMTPEKVP VSEVMGTTLA EMSTPEATGM TPAEVSIWL SGTTAAQVTT 420 TEWVETTARE LPIPEPEGPD ASSIMSTESI TGSLGPLLDG TATLRLVKRQ VPLDCVLYRY 480 GSFSVTLDIV QGIESAEILQ AVPSGEGDAF ELTVSCQGGL PKEACMEISS PGCQPPAQRL 540 CQPVLPSPAC QLVLHQILKG GSGTYCLNVS LADTNSLAW STQLIMPGQE AGLGQVPLIV 600 GILLVLMAW LASLIYRRRL MKQDFSVPQL PHSSSHWLRL PRIFCSCPIG ENSPLLSGQQ 660 V 661 Seq ID NO : 332 Protein Sequence Protein Accession 4 : NP 001913. 2 1 11 21 31 41 51 MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ 60 CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER 120 KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWLGLLGPN GTQPQFANCS 180 VYDFFVWLHY YSVRDTLLGP GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF 240 ALPYWNFATG RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN 300 GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA LEGFDKADGT 360 LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFWLHSFTD AIFDEWMKRF NPPADAWPQE 420 LAPIGHNRMY NMVPFFPPVT NEELFLTSDQ LGYSYAIDLP VSVEETPGWP TTLLWMGTL 480 VALVGLFVLL AFLQYRRLRK GYTPLMETHL SSKRYTEEA 519 Seq ID NO : 333 Protein Sequence Protein Accession # : XP 059422. 1 1 11 21 31 41 51 MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN IVISPHGIAS 60 VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV SKKNKDIVTV ANAVFVKNAS 120 EIEVPFVTRN KDVFQCEVRN VNFEDPASAC DSINAWVKNE TRDMIDNLLS PDLIDGVLTR 180 LVLVNAVYFK GLWKSRFQPE NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN 240 FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 300 QTDLKEPLKV LGITDMFDSS KANFAKITRS ENLHVSHILQ KAKIEVSEDG TKASAATTAI 360 LIARSSPPWF IVDRPFLFFI RHNPTGAVLF MGQINKP 397 Seq ID NO : 334 Protein Sequence Protein Accession # : XP 040512. 2 1 11 21 31 41 51 MRQHDTRNGR IVLISGRRSF CSIFSVLPYR DSTQVGDLKL DGGRQSTGAV SLKEIIGLEG 60 VELGADGKTV SYTQFLLPTN AFGARRNTID STSSFSQFRN LSHRSLSIGR ASGTQGSLDT 120 GSDLGDFMDY DPNLLDDPQW PCGKHKRVLI FPSYMTTVID YVKPSDLKKD MNETFKEKFP 180 HIKLTLSKIR SLKREMRKLA QEDCGLEEPT VAMAFVYFEK LALKGKLNKQ NRKLCAGACV 240 LLAAKIGSDL KKHEVKHLID KLEEKFRLNR RELIAFEFPV LVALEFALHL PEHEVMPHYR 300 RLVQSS 306 Seq ID NO : 335 Protein Sequence Protein Accession # : AAH08826 1 11 21 31 41 51 MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV 60 EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKVTT PDVEKKIEEY 120 KRENPGMFSW EIRDKLLKDA VCDRNTVPSV SSISRILRSK FGKGEEEEAD LERKEAEESE 180 KKAKHSIDGI LSERASAPQS DEGSDIDSEP DLPLKRKQRR SRTTFTAEQL EELERAFERT 240 HYPDIYTREE LAQRAKLTEA RVQVWFSNRR ARWRKQAGAN QLMAFNHLIP GGFPPTAMPT 300 LPTYQLSETS YQPTSIPQAV SDPSSTVHRP QPLPPSTVHQ STIPSNPDSS SAYCLPSTRH 360 GFSSYTDSFV PPSGPSNPMN PTIGNGLSPQ NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN 420 PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG 480 SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP 540 SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN 600 YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV 660 DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP 720 HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS 780 DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG 835

Seq ID NO : 336 Protein Sequence Protein Accession # : NP 005752. 1 1 11 21 31 41 51 MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA ASQEDGVFVA 60 SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR PGSSFSKLLL PYREGAAGLG 120 GLLLTGWTFD RGACEVRPLG NLSRNSLRNG TEWSCHPQG STAGWYRAG RNNRWYLAVA 180 ATYVLPEPET ASRCNPAASD HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW 240 NGSIYFPYYP YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV 300 EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA ESHCKEGDQP 360 ERVQPIASST LIHSDLTSVY GTWMNRTVL FLGTGDGQLL KVILGENLTS NCPEVIYEIK 420 EETPVFYKLV PDPVKNIYIY LTAGKEVRRI RVANCNKHKS CSECLTATDP HCGWCHSLQR 480 CTFQGDCVHS ENLENWLDIS SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD 540 SSRELCQNKS QPNRTCTCSI PTRATYKDVS WNVMFSFGS WNLSDRFNFT NCSSLKECPA 600 CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN KGNRTNQALQ 660 VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT STCDKDVIQV SHVLNDTHMK 720 FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY IALPHCSLIF PATTWISGGQ NITMMGRNFD 780 VIDNLIISHE LKGNINVSEY CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY 840 REDPRFTGYR VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ 900 DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV LPVLLVIVIF 960 AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ MDKLDWDSF GTVPFLDYKH 1020 FALRTFFPES GGFTHIFTED MHNRDANDKN ESLTALDALI CNKSFLVTVI HTLEKQKNFS 1080 VKDRCLFASF LTIALQTKLV YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SWEKLLTNW 1140 MSVCLSGFLR ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA 1200 LNWFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG LQLNEIGLEL 1260 QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI KVFKKIANFT SDVEYSDDHC 1320 HLILPDSEAF QDVQGKRHRG KHKFKVKEMY LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA 1380 PFAIKYFFDF LDAQAENKKI TDPDWHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG 1440 CLSVIAQAFM DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM 1500 EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK QLLHVKVLFD 1560 EKKKCKWM 1568 Seq ID NO : 337 Protein Sequence Protein Accession # : XP 063670. 1 1 11 21 31 41 51 ( MQRILEEPAD DCTWSTRILL TLSEFIMSLQ RTVYPHSEKW RALSVPSSSY FQELVGTSQE 60 LALTFWHLLS MFGFFIVSYG FLTAFGRTLF HLDLLQPNLT PSRFDKYTGL FIYEIEGDGL 120 DPCFQSMVQG ILEVLWMSKV ESAYHTNDGD TAGEGVENGT SQTRGGGGAA RSRCREMEEP 180 TPEPVYVDVD KGLTLACFVF LCLFLWMII RCAKVIMDPY SAIPTSTWEE QHLDD 235 Seq ID NO : 338 Protein Sequence Protein Accession # : FGENESH predicted 1 11 21 31 41 51 MEPSHSQPTM DMKHMQERPA ASPLKCQDGR GSAQSPLSAA GPGSPAPLGA LTPAEPGLGS 60 APRAPRARAP VTGKRRSRRS AVALGSAPAQ PGPRERTGRA SPALENNSDL LSKASAIATG 120 TPPCEDSTIA RFYLPPPLTT HPELVGTSQE LALTFWHLLS MFGFFIVSYG FLTAFGRTLF 180 HLDLLQPNLT PSRFDKYTGQ LLELPVHSKY VLTIHWSQGL CIWSSHPCEA GVENGTSQTR 240 GGGGAARSRC REMEEPTPEP VYVDVDKGLT LACFVFLCLF LWMIIRCAK VIMDPYSAIP 300 TSTWEEQHLD D 311 Seq ID NO : 339 Protein Sequence Protein Accession # : FGENESH predicted 1 11 21 31 41 51 MGKDFMSKTP KAMATQAKID KWDLIKLKSF CTAKETTIRV NRQPTEWEKI FAIYSSDEGL 60 ISRIYNEPKQ IYKKKTNNPI NKWAKDMNRH FSKEDIYAAN RHMKKCSSSL AIREMQIKTT 120 TRCHLTPVRM AIIKKSGNNR TAEEQPKLRK EAVGSIEIFR FADGLDITLM ILGILASLVN 180 GACLPLMPLV LGEMSDNLIS GCLVQTNTTN YQNCTQSQEK LNEDMTLLTL YYVGIGVAAL 240 IFGYIQISLW IITAARQTKR IRKQFFHSVL AQDIGWFDSC DIGELNTRMT DDIDKISDGI 300 GDKIALLFQN MSTFSIGLAV GLVKGWKLTL VTLSTSPLIM ASAAACSRMV ISLTSKELSA 360 YSKAGAVAEE VLSSIRTVIA FRAQEKELQR YTQNLKDAKD FGIKRTIASK VSLGAVYFFM 420 NGTYGLAFWY GTSLILNGEP GYTIGTVLAV FFSVIHSSYC IGAAVPHFET FAIARGAAFH 480 IFQVIDKKPS IDNFSTAGYK PESIEGTVEF KNVSFNYPSR PSIKILKGLN LRIKSGETVA 540 LVGLNGSGKS TWQLLQRLY DPDDGFIMVD ENDIRALNVR HYRDHIGWS QEPVLFGTTI 600 SNNIKYGRDD VTDEEMERAA REANAYDFIM EFPNKFNTLV GEKGAQMSGG QKQRIAIARA 660 LVRNPKILIL DEATSALDSE SKSAVQAALE KDTPRYSF 698 Seq ID NO : 340 Protein Sequence Protein Accession # : XP 166496. 1 1 11 21 31 41 51 MVDENDIRAL NVRHYRDHIG WSQEPVLFG TTISNNIKYG RDDVTDEEME RAAREANAYD 60 FIMEFPNKFN TLVGEKGAQM SGGQKQRIAI ARALVRNPKI LILDEATSAL DSESKSAVQA 120 ALEKDTPRYS F 131 Seq ID NO : 341 Protein Sequence Protein Accession # : XP_166305. 1 1 11 21 31 41 51 MEKFRAVLDL HVKHHSALGY GLVTLLTAGG ERIFSAVAFQ CPCSAAWNLP YGLVFLLVPA 60 LALFLLGYVL SARTWRLLTG CCSS. ARASCG SALRGSLVCT QISAAAALAP LTWVAVALLG 120 GAFYECAATG SAAFAQRLCL GRNRSCAAEL PLVPCNQAKA SDVQDLLKDL KAQSQVLGWI 180

LIAWIIILL IFTSVTRCLS PVSFLQLKFW KIYLEQEQQI LKSKATEHAT ELAKENIKCF 240 FEGSHPKEYN TPSMKEWQQI SSLYTFNPKG QYYSMLHKYV NRKEKTHSIR STEGDTVIPV 300 LGFVDSSGIN STPEL 315 Seq ID NO : 342 Protein Sequence Protein Accession # : NP 115587. 5 1 11 21 31 41 51 MARSPPATLF LFLLLLGQPP PSRPQSLGTT KLRLVGPESK PEEGRLEVLH QGQWGTVCDD 60 NFAIQEATVA CRQLGFEAAL TWAHSAKYGQ GEGPIWLDNV QCVGTESSLD QCGSNGWGVS 120 DCSHSEDVGV ICHPRRHRGY LSETVSNALG PQGRRLEEVR LKPILASAKQ HSPVTEGAVE 180 VKYEGHWRQV CDQGWTMNNS RWCGMLGFP SEVPVDSHYY RKVWDLKMRD PKSRLKSLTN 240 KNSFWIHQVT CLGTEPHMAN CQVQVAPARG KLRPACPGGM HAWSCVAGP HFRPPKTKPQ 300 RKGSWAEEPR VRLRSGAQVG EGRVEVLMNR QWGTVCDHRW NLISASWCR QLGFGSAREA 360 LFGARLGQGL GPIHLSEVRC RGYERTLSDC PALEGSQNGC QHENAAAVRC NVPNMGFQNQ 420 VRLAGGRIPE EGLLEVQVEV NGVPRWGSVC SENWGLTEAM VACRQLGLGF AIHAYKETWF 480 WSGTPRAQEV VMSGVRCSGT ELALQQCQRH GPVHCSHGGG RFLAGVSCMD SAPDLVMNAQ 540 LVQETAYLED RPLSQLYCAH EENCLSKSAD HMDWPYGYRR LLRFSTQIYN LGRTDFRPKT 600 GRDSWVWHQC HRHYHSIEVF THYDLLTLNG SKVAEGHKAS FCLEDTNCPT GLQRRYACAN 660 FGEQGVTVGC WDTYRHDIDC QWVDITDVGP GNYIFQVIVN PHYEVAESDF SNNMLQCRCK 720 YDGHRVWLHN CHTGNSYPAN AELSLEQEQR LRNNLI 756 Seq ID NO : 343 Protein Sequence Protein Accession # : NP 001789. 2 1 11 21 31 41 51 MENFQKVEKI GEGTYGWYK ARNKLTGEW ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60 PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120 HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEWTLWYRA PEILLGCKYY 180 STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEWWPGV TSMPDYKPSF 240 PKWARQDFSK WPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL 298 Seq ID NO : 344 Protein Sequence Protein Accession # : NP 439892. 1 1 11 21 31 41 51 MENFQKVEKI GEGTYGWYK ARNKLTGEW ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60 PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120 HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVTRRALFP GDSEIDQLFR 180 IFRTLGTPDE WWPGVTSMP DYKPSFPKWA RQDFSKWPP LDEDGRSLLS QMLHYDPYKR 240 ISAKAALAHP FFQDVTKPVP HLRL 264 Seq ID NO : 345 Protein Sequence Protein Accession # : NP 116127. 1 1 11 21 31 41 51 MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF 60 QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ AWQDWPLTQV TFYRDGSALG 120 PPGPNREFSI TWQKADSGH YHCSGIFQSP GPGIPETASV VAITVQELFP APILRAVPSA 180 EPQAGSPMTL SCQTKLPLQR SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC 240 EAATEDNQVW KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS 300 SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHQK PGTTKATAE 359 Seq ID NO : 346 Protein Sequence Protein Accession ft : NP 002337. 1 1 11 21 31 41 51 MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT VSASAGIGNL 60 VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF SAADGGLRAS VTLLGAGLLL 120 SLLPALLRFG P 131 Seq ID NO : 347 Protein Sequence Protein Accession # : XP 113526. 2 1 11 21 31 41 51 MEDLGENTMV LSTLRSLNNF ISQRVEGGSG LDISTSAPGS LQMQYQQSMQ LEERAEQIRS 60 KSHLIQVERE KMQMELSHKR ARVELERAAS TSARNYEREV DRNQELLTRI RQLQEREAGA 120 EEKMQEQLER NRQCQQNLDA ASKRLREKED SLAQAGETIN ALKGRISELQ WSVMDQEMRV 180 KRLESEKQEL QEQLDLQHKK CQEANQKIQE LQASQEARAD HEQQIKDLEQ KLSLQEQDAA 240 IVKNMKSELV RLPRLERELK QLREESAHLR EMRETNGLLQ EELEGLQRKL GRQEKMQETL 300 VGLELENERL LAKLQSWERL DQTMGLSIRT PEDLSRFWE LQQRELALKD KNSAVTSSAR 360 GLEKARQQLQ EELRQVSGQL LEERKKRETH EALARRLQKR VLLLTKERDG MRAILGSYDS 420 ELTPAEYSPQ LTRRMREAED MVQKVHSHSA EMEAQLSQAL EELGGQKQRA DMLEMELKML 480 KSQSSSAEQS FLFSREEADT LRLKVEELEG ERSRLEEEKR MLEAQLERRA LQGDYDQSRT 540 KVLHMSLNPT SVARQRLRED HSQLQAECER LRGLLRAMER GGTVPADLEA AAASLPSSKE 600 VAELKKQVES AELKNQRLKE VFQTKIQEFR KACYTLTGYQ IDITTENQYR LTSLYAEHPG 660 DCLIFKATSP SGSKMQLLET EFSHTVGELI EVHLRRQDSI PAFLSSLTLE LFSRQTVA 718 Seq ID NO : 348 Protein Sequence Protein Accession # : NP000264. 1 1 11 21 31 41 51 MTQAGRRGPG TPEPRPRTQP MASPRLGTFC CPTRDAATQL VLSFQPRAFH ALCLGSGGLR 60 LALGLLQLLP GRRPAGPGSP ATSPPASVRI LRAAAACDLL GCLGMVIRST VWLGFPNFVD 120

SVSDMNHTEI WPAAFCVGSA MWIQLLYSAC FWWLFCYAVD AYLVIRRSAG LSTILLYHIM 180 AWGLATLLCV EGAAMLYYPS VSRCERGLDH AIPHYVTMYL PLLLVLVANP ILFQKTVTAV 240 ASLLKGRQGI YTENERRMGA VIKIRFFKIM LVLIICWLSN IINESLLFYL EMQTDINGGS 300 LKPVRTAAKT TWFIMGILNP AQGFLLSLAF YGWTGCSLGF QSPRKEIQWE SLTTSAAEGA 360 HPSPLMPHEN PASGKVSQVG GQTSDEALSM LSEGSDASTI EIHTASESCN KNEGDPALPT 420 HGDL 424 Seq ID NO : 349 Protein Sequence Protein Accession # : NP 647478. 1 1 11 21 31 41 51 MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR 60 PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD 120 KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW 180 EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE 240 AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS 298 Seq ID NO : 350 Protein Sequence Protein Accession # : NP 071444. 1 1 11 21 31 41 51 1 1 1 1 1 1 MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR 60 PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD 120 KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW 180 EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGARD VEAQLRRLQE ERTCKVCLDR 240 AVSIVFVPCG HLVCAECAPG LQLCPICRAP VRSRVRTFLS 280 Seq ID NO : 351 Protein Sequence Protein Accession # : NP 066300. 1 1 11 21 31 41 51 MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG 60 KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG 120 AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS 180 SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG 240 HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR 300 RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE 360 TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK 420 DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA 480 QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI 540 QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI 596 Seq ID NO : 352 Protein Sequence Protein Accession # : AAG41361. 1 1 11 21 31 41 51 MPKNSKWKR ELDDDVTESV KDLLSNEDAA DDAFKTSELI VDGQEEKDTD VEEGSEVEDE 60 RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL LPYLILLMVI GIPLFFLELS 120 VGQRIRRGSI GVWNYISPKL GGIGFASCW CYFVALYYNV IIGWSLFYFS QSFQQPLPWD 180 QCPLVKNASH TFVEPECEQS SATTYYWYRE ALNISSSISE SGGLNWKMTI CLLAAWVMVC 240 LAMIKGIQSS GKIIYFSSLF PYWLICFLI RAFLLNGSID GIRHMFTPKL EIMLEPKVWR 300 EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL WFAVLGFKA 360 NVINEKCITQ NSETIMKFLK MGNISQDIIP HHINLSTVTA EDYHLVYDII QKVKEEEFPA 420 LHLNSCKIEE ELNKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE 480 GIVTPIVDTF KVRKEILTVI CCLLAFCIGL IFVQRSGNYF VTMFDDYSAT LPLLIWILE 540 NIAVCFVYGI DKFMEDLKDM LGFAPSRYYY YMWKYISPLM LLSLLIASW NMGLSPPGYN 600 AWIEDKASEE FLSYPTWGLV VCVSLWFAI LPVPWFIVR RFNLIDDSSG NLASVTYKRG 660 RVLKEPVNLE GDDTSLIHGK IPSEMPSPNF GKNIYRKQSG SPTLDTAPNG RYGIGYLMAD 720 IMPDMPESDL 730 Seq ID NO : 353 Protein Sequence Protein Accession # : NP 005594. 1 1 11 21 31 41 51 MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP ETKHQALSGT 60 PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW GLAVKGSLGS DLGGPLPTDP 120 MLGLALGGLV VSAASLAGCL GALCENTCLL RGFSGGILAF LVLEAVAGAL WALWGPLQD 180 SLEHTLRVAI AHYQDDPDLR FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP 240 ASCCIDPRED GASVNDQCGF GVLRLDADAA QRWYLEGCG PPLRRWLRAN LAASGGYAIA 300 WLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA KPARG 355 Seq ID NO : 354 Protein Sequence Protein Accession # : AAL84622. 1 1 11 21 31 41 51 MADPEWVSS CSSHEEENRC NFNQQTSPSE ELLLEDQMRR KLKFFFMNPC EKFWARGRKP 60 WKLAIQILKI AMVTIQLVLF GLSNQMWAF KEENTIAFKH LFLKGYMDRM DDTYAVYTQS 120 DVYDQLIFAV NQYLQLYNVS VGNHAYENKG TKQSAMAICQ HFYKRGNIYP GNDTFDIDPE 180 IETECFFVEP DEPFHIGTPA ENKLNLTLDF HRLLTVELQF KLKAINLQTV RHQELPDCYD 240 FTLTITFDNK AHSGRIKISL DNDISIRECK DWHVSGSIQK NTHYMMIFDA FVILTCLVSL 300 ILCIRSVIRG LQLQQEFVNF FLLHYKKEVS VSDQMEFVNG WYIMIIISDI LTIIGSILKM 360 EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFAKYNL LILTLQAALP NVIRFCCCAA 420 MIYLGYCFCG WIVLGPYHDK FRSLNMVSEC LFSLINGDDM FATFAKMQQK SYLVWLFSRI 480 YLYSFISLFI YMILSLFIAL ITDTYETIKQ YQQDGFPETE LRTFISECKD LPNSGKYRLE 540

DDPPVSLFCC CKK 553 Seq ID NO : 355 Protein Sequence Protein Accession # : NP 000105. 1 1 11 21 31 41 51 MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG 60 PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT 120 PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS 180 SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP 238 Seq ID NO : 356 Protein Sequence Protein Accession # : NP 005347. 2 1 11 21 31 41 51 MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 60 LQDNLVIALH SYEPSHDGDL GFEKGEPLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120 SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEWKH 180 YKIRNLDNGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240 PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300 VRLYAWTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY 360 IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420 SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER 480 PEDRPTFDYL RSVLEDFFTA TEGQYQPQP 509 Seq ID NO : 357 Protein Sequence Protein Accession # : NP 055469. 1 1 11 21 31 41 51 1 1 1 1 1 1 MAIAYLGSSC PSQPPSSLAL SLSPTPSDFE QESGIETAMR FSPDVALAVS TTPAVLPTTN 60 IQPVGTPFEE LPSERPTLEP ATSPLWTEV PEEPSQRATT VSTTMATTAA TSTGDPTVAT 120 VPATVATATP STPAAPPFTA TTAVIRTTGV RRLLPLPLTT VATARATTPE APSPPTTAAV 180 LDTEAPTPRL VSTATSRPRA LPRPATTQEP DIPERSTLPL GTTAPGPTEV AQTPTPETFL 240 TTIRDEPEVP VSGGPSGDFE LPEEETTQPD TANEWAVGG AAAKASSPPG TLPKGARPGP 300 GLLDNAIDSG SSAAQLPQKS ILERKEVLVA VIVGGWGAL FAAFLVTLLI YRMKKKDEGS 360 YTLEEPKQAS VTYQKPDKQE EFYA 384 Seq ID NO : 358 Protein Sequence Protein Accession # : NP 008848. 1 1 11 21 31 41 51 MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG 60 TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NWNSVSSSE DIKPLPGLPG 120 IGNMNYPSTS PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD 180 CLIDKRQRNR CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL 240 EAELAVEPKT ESYGCMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI 300 LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV LTELVSKMKD 360 MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT LEAYTKQKYP EQPGRFAKLL 420 LRLPALRSIG LKCLEHLFFF KLIGDTPIDT FLMEMLETPL QIT 463 Seq ID NO : 359 Protein Sequence Protein Accession # : NP 002176. 1 1 11 21 31 41 51 MTILGTTFGM VFSLLQWSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 60 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 120 IDLTTIVKPE APFDLSVIYR EGANDFWTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 180 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 240 ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 300 ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVWTPES 360 FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 420 LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ 459 Seq ID NO : 360 Protein Sequence Protein Accession # : NP006263. 1 1 11 21 31 41 51 I I I I I I MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEWDKVMET 60 LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE 92 Seq ID NO : 361 Protein Sequence Protein Accession # : Nu 006148. 1 1 11 21 31 41 51 MPMDLILWM FCVCTARTW GFGMDPDLOM DIVTELDLVN TTLGVAQVSG MHNASKAFLF 60 QDIEREIHAA PHVSEKLIQL FQNKSEFTIL ATVQQKPSTS GVILSIRELE HSYFELESSG 120 LRDEIRYHYI HNGKPRTEAL PYRMADGQWH KVALSVSASH LLLHVDCNRI YERVIDPPDT 180 NLPPGINLWL GQRNQKHGLF KGIIQDGKII FMPNGYITQC PNLNHTCPTC SDFLSLVQGI 240 MDLQELLAKM TAKLNYAETR LSQLENCHCE KTCQVSGLLY RDQDSWVDGD HCRNCTCKSG 300 AVECRRMSCP PLNCSPDSLP VHIAGQCCKV CRPKCIYGGK VLAEGQRILT KSCRECRGGV 360 LVKITEMCPP LNCSEKDHIL PENQCCRVCR GHNFCAEGPK CGENSECKNW NTKATCECKS 420 GYISVQGDSA YCEDIDECAA KMHYCHANTV CVNLPGLYRC DCVPGYIRVD DFSCTEHDEC 460

GSGQHNCDEN AICTNTVQGH SCTCKPGYVG NGTICRAFCE EGCRYGGTCV APNKCVCPSG 540 FTGSHCEKDI DECSEGIIEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 600 ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWTLK EDRCSVCSCK 660 DGKIFCRRTA CDCQNPSADL FCCPECDTRV TSQCLDQNGH KLYRSGDNWT HSCQQCRCLE 720 GEVDCWPLTC PNLSCEYTAI LEGECCPRCV SDPCLADNIT YDIRKTCLDS YGVSRLSGSV 780 WTMAGSPCTT CKCKNGRVCC SVDFECLQNN 810 Seq ID NO : 362 Protein Sequence Protein Accession # : NP 057264. 1 1 11 21 31 41 51 MGSNSGQAGR HIYKSLADDG PFDSVEPPKR AMFGREFCYA VEAAYVTPVL 60 LSVGLPSSLY SIVWFLSPIL GFLLQPWGS ASDHCRSRWG RRRPYILTLG VMMLVGMALY 120 LNGATWAAL IANPRRKLVW AISVTMIGW LFDFAADFID GPIKAYLFDV CSHQDKEKGL 180 HYHALFTGFG GALGYLLGAI DWAHLELGRL LGTEFQVMFF FSALVLTLCF TVHLCSISEA 240 PLTEVAKGIP PQQTPQDPPL SSDGMYEYGS IEKVKNGYVN PELAMQGAKN KNHAEQTRRA 300 MTLKSLLRAL VNMPPHYRYL CISHLIGWTA FLSNMLFFTD FMGQIVYRGD PYSAHNSTEF 360 LIYERGVEVG CWGFCINSVF SSLYSYFQKV LVSYIGLKGL YFTGYLLFGL GTGFIGLFPN 420 VYSTLVLCSL FGVMSSTLYT VPFNLITEYH REEEKERQQA PGGDPDNSVR GKGMDCATLT 480 CMVQLAQILV GGGLGFLVNT AGTWVWIT ASAVALIGCC FVALFVRYVD 530 Seq ID NO : 363 Protein Sequence Protein Accession # : NP 036532. 1 1 11 21 31 41 51 MELALLCGLV VMAGVIPIQG GILNLNKMVK QVTGKMPILS YWPYGCHCGL GGRGQPKDAT 60 DWCCQTHDCC YDHLKTQGCS IYKDYYRYNF SQGNIHCSDK GSWCEQQLCA CDKEVAFCLK 120 RNLDTYQKRL RFYWRPHCRG QTPGC 145 Seq ID NO : 364 Protein Sequence Protein Accession # : NP 061313. 1 1 11 21 31 41 51 MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 60 FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 120 PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 180 GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 240 FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKWG LYGFMLSISP RLTLLSLLHM 300 PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ WREAVGGLQ TVRSFGAEEH EVCRYKEALE 360 QCRQLYWRRD LERALYLLIR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 420 SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGWKF QDVSFAYPNR 480 PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 540 YLHSQWSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 600 GEKGSQLAAG QKQRLAIARA LVRDPRVLIL 630 Seq ID NO : 365 Protein Sequence Protein Accession # : NP 002407 1 11 21 31 41 51 ( MKKSGVLFLL GIILLVLIGV QGTPWRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK 60 IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR 120 QKKTT Seq ID NO : 366 Protein Sequence Protein Accession # : NP 006524. 1 1 11 21 31 41 51 ( MARSLVCLGV IILLSAFSGP GVRGGPMPKL ADRKLCADQE CSHPISMAVA LQDYMAPDCR 60 FLTIHRGQW YVFSKLKGRG RLFWGGSVQG DYYGDLAARL GYFPSSIVRE DQTLKPGKVD 120 VKTDKWDFYC Q 131 It is understood that the examples described above in no way serve to limit the true scope of this invention, but rather are presented for illustrative purposes. All publications, sequences of accession numbers, and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.