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Title:
METHODS FOR ELECTRONIC FLUORESCENT PERTURBATION FOR ANALYSIS AND ELECTRONIC PERTURBATION CATALYSIS FOR SYNTHESIS
Document Type and Number:
WIPO Patent Application WO1998051819
Kind Code:
A9
Abstract:
Methods for electronic perturbation of fluorescent, chemiluminescence and other emissive materials provide for molecular biological analysis. In a preferred method for hybridization analysis of a sample, an electronic stringency control device is used to perform the steps of: providing the sample, a first probe with a fluorescent label and a second probe with a label under hybridization conditions on the electronic stringency control device, forming a hybridization product, subjecting the hybridization product to an electric field force, monitoring the fluorescence from the hybridization product, and analyzing the fluorescent signal. In yet another aspect of this invention, a method is provided for achieving electronic fluorescence perturbation on an electronic stringency control device. In yet another aspect of this invention, a method is provided for electronic perturbation catalysis of substrate molecules on an electronic control device containing at least one microlocation.

Inventors:
HELLER MICHAEL J
TU EUGENE
SOSNOWSKI RONALD G
O'CONNELL JAMES P
Application Number:
PCT/US1998/009357
Publication Date:
March 25, 1999
Filing Date:
May 07, 1998
Export Citation:
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Assignee:
NANOGEN INC (US)
International Classes:
B01J19/00; B01L3/00; B82B3/00; C07B61/00; C07H21/00; C07K1/04; C12Q1/68; G01N33/543; G02B6/122; G06N3/00; G06N3/06; G06N3/12; G11B7/0037; G11B7/0045; G11B7/005; G11B7/24; G11B7/244; G11C13/02; G11C13/04; G11C19/00; H01L21/336; H01L21/98; H01L29/78; C40B40/06; C40B40/10; C40B40/12; C40B60/14; C40B70/00; H01L51/00; H01L51/30; (IPC1-7): C12Q1/68
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