METHODS FOR FORMING DYED MICROSPHERES AND POPULATIONS OF DYED MICROSPHERES

WIPO Patent Application WO2006044413

A3

Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.

HOFFACKER KURT D (US)
LUGADE ANANDA G (US)
TERPETSCHNIG EWALD (US)

PCT/US2005/036571

June 22, 2006

October 11, 2005

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LUMINEX CORP (US)
HOFFACKER KURT D (US)
LUGADE ANANDA G (US)
TERPETSCHNIG EWALD (US)

C09B69/10; G01N33/58; G01N33/68

WO2003003806A2	2003-01-16
WO1999037814A1	1999-07-29
WO1999052708A1	1999-10-21

US6022597A	2000-02-08
US20030028981A1	2003-02-13
US20040053052A1	2004-03-18
US20020096795A1	2002-07-25
US5580697A	1996-12-03
US6737236B1	2004-05-18
GB1344991A	1974-01-23
US6514295B1	2003-02-04
US3695821A	1972-10-03

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