Title:
METHODS FOR FORMING PROTECTED ORGANOBORONIC ACIDS
Document Type and Number:
WIPO Patent Application WO/2011/103435
Kind Code:
A3
Abstract:
Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid.
Inventors:
BURKE MARTIN D (US)
DICK GRAHAM R (CA)
KNAPP DAVID M (US)
GILLIS ERIC P (US)
KLUBNICK JENNA A (US)
DICK GRAHAM R (CA)
KNAPP DAVID M (US)
GILLIS ERIC P (US)
KLUBNICK JENNA A (US)
Application Number:
PCT/US2011/025446
Publication Date:
January 19, 2012
Filing Date:
February 18, 2011
Export Citation:
Assignee:
UNIV ILLINOIS (US)
BURKE MARTIN D (US)
DICK GRAHAM R (CA)
KNAPP DAVID M (US)
GILLIS ERIC P (US)
KLUBNICK JENNA A (US)
BURKE MARTIN D (US)
DICK GRAHAM R (CA)
KNAPP DAVID M (US)
GILLIS ERIC P (US)
KLUBNICK JENNA A (US)
International Classes:
C07F5/04; C07C229/16; C07D265/33
Foreign References:
| US20090030238A1 | 2009-01-29 | |||
| US6096906A | 2000-08-01 |
Other References:
GILLIS, E. P. ET AL.: "A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki-Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks", J. AM. CHEM. SOC., vol. 129, no. 21, 2007, pages 6716 - 6717
Attorney, Agent or Firm:
GORDON, Dana, M. et al. (Foley Hoag LLPSeaport West, 155 Seaport Boulevar, Boston MA, US)
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