Title:
METHODS FOR GENERATION OF TUMOR ORGANOID-FISHED T CELLS AND IDENTIFICATION OF ANTI-TUMOR T CELL RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2020/243416
Kind Code:
A3
Abstract:
Provided herein are methods for obtaining tumor-targeting T cells, as well as for identifying tumor-targeting TCRs.
Inventors:
HIDALGO MANUEL (US)
MUTHUSWAMY SENTHIL K (US)
MUTHUSWAMY SENTHIL K (US)
Application Number:
PCT/US2020/035099
Publication Date:
January 07, 2021
Filing Date:
May 29, 2020
Export Citation:
Assignee:
BETH ISRAEL DEACONESS MEDICAL CT INC (US)
International Classes:
A61K39/395; A61K49/16; A61K49/18; A61P35/04; C12N5/02; G01N33/50
Other References:
COURAU ET AL.: "Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 7, 14 March 2019 (2019-03-14), XP002795053, DOI: 10.1186/s40425-019-0553-9
DIJKSTRA ET AL.: "Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids", CELL, vol. 174, no. 6, 2018, pages 1586 - 1598, XP055722242, DOI: 10.1016/j.cell.2018.07.009
JULIANE WAGNER, VIKTORIA PFANNENSTIEL, ANJA WALDMANN , JUDITH W. J. BERGS, BORIS BRILL , SABINE HUENECKE, THOMAS KLINGEBIEL , FRAN: "A Two-Phase Expansion Protocol Combining Interleukin (IL) -15 and IL -21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma", FRONT. IMMUNOL, vol. 8, 2017, pages 1 - 16, XP055774621
KINTER ET AL.: "The common gamma-chain cytokines IL -2, IL -7, IL -15, and IL -21 induce the expression of programmed death-1 and its ligands", J IMMUNOL, vol. 181, no. 10, 2008, pages 6738 - 6746, XP055606263, DOI: 10.4049/jimmunol.181.10.6738
ANONYMOUS: "History of Changes for Study: NCT03412877 Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer", 16 April 2019 (2019-04-16), US, pages 1 - 6, XP009532710, Retrieved from the Internet [retrieved on 20200914]
DIJKSTRA ET AL.: "Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids", CELL, vol. 174, no. 6, 2018, pages 1586 - 1598, XP055722242, DOI: 10.1016/j.cell.2018.07.009
JULIANE WAGNER, VIKTORIA PFANNENSTIEL, ANJA WALDMANN , JUDITH W. J. BERGS, BORIS BRILL , SABINE HUENECKE, THOMAS KLINGEBIEL , FRAN: "A Two-Phase Expansion Protocol Combining Interleukin (IL) -15 and IL -21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma", FRONT. IMMUNOL, vol. 8, 2017, pages 1 - 16, XP055774621
KINTER ET AL.: "The common gamma-chain cytokines IL -2, IL -7, IL -15, and IL -21 induce the expression of programmed death-1 and its ligands", J IMMUNOL, vol. 181, no. 10, 2008, pages 6738 - 6746, XP055606263, DOI: 10.4049/jimmunol.181.10.6738
ANONYMOUS: "History of Changes for Study: NCT03412877 Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer", 16 April 2019 (2019-04-16), US, pages 1 - 6, XP009532710, Retrieved from the Internet
Attorney, Agent or Firm:
DEYOUNG, Janice Kugler et al. (US)
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