Title:
METHODS FOR HAPLOTYPE AND DIPLOTYPE DETERMINATION
Document Type and Number:
WIPO Patent Application WO/2018/166463
Kind Code:
A1
Abstract:
The present invention provides methods for determining a haplotype or a diplotype in a genetic sample. The method comprises the steps of contacting a probe-complex with the genetic sample, wherein the probe complex comprises at least two probes, hybridizing at least two probes to a polynucleotide sequence, each of which is specific to one of two or more genetic variants, determining the presence or absence of at least one genetic variant by detecting a signal emitted from at least one probe, wherein detection of said signal is indicative of the presence of a genetic variant, removing or displacing at least one of said probes from said sample, and detecting a change in the signal to determine the haplotype or a diplotype in the genetic sample. Kits for use in the method of the invention are also provided.
Inventors:
HSING I MING (CN)
FAN TSZ WING (CN)
LEE YU HENSON LIM (CN)
FAN TSZ WING (CN)
LEE YU HENSON LIM (CN)
Application Number:
PCT/CN2018/078938
Publication Date:
September 20, 2018
Filing Date:
March 14, 2018
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
C12Q1/68
Foreign References:
| EP2064345A2 | 2009-06-03 | |||
| EP1669447A1 | 2006-06-14 |
Attorney, Agent or Firm:
CHINA PAT INTELLECTUAL PROPERTY OFFICE (CN)
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