Title:
METHODS FOR IDENTIFICATION AND MODIFICATION OF LNCRNA ASSOCIATED WITH TARGET GENOTYPES AND PHENOTYPES
Document Type and Number:
WIPO Patent Application WO/2018/204777
Kind Code:
A3
Abstract:
The application relates to methods for compositions for identifying IncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.
Inventors:
JOUNG JULIA (US)
ENGREITZ JESSE (US)
LANDER ERIC S (US)
ZHANG FENG (US)
ENGREITZ JESSE (US)
LANDER ERIC S (US)
ZHANG FENG (US)
Application Number:
PCT/US2018/031075
Publication Date:
December 06, 2018
Filing Date:
May 04, 2018
Export Citation:
Assignee:
BROAD INST INC (US)
MASSACHUSETTS INST TECHNOLOGY (US)
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
A61P35/00
Domestic Patent References:
| WO2015024986A1 | 2015-02-26 |
Other References:
JULIA JOUNG ET AL: "Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood", NATURE, vol. 548, no. 7667, 9 August 2017 (2017-08-09), GB, pages 343 - 346, XP055438120, ISSN: 0028-0836, DOI: 10.1038/nature23451
N. E. SANJANA ET AL: "High-resolution interrogation of functional elements in the noncoding genome", SCIENCE, vol. 353, no. 6307, 30 September 2016 (2016-09-30), US, pages 1545 - 1549, XP055500550, ISSN: 0036-8075, DOI: 10.1126/science.aaf7613
SILVANA KONERMANN ET AL: "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", NATURE, vol. 517, no. 7536, 10 December 2014 (2014-12-10), GB, pages 583 - 588, XP055294959, ISSN: 0028-0836, DOI: 10.1038/nature14136
N. E. SANJANA ET AL: "High-resolution interrogation of functional elements in the noncoding genome", SCIENCE, vol. 353, no. 6307, 30 September 2016 (2016-09-30), US, pages 1545 - 1549, XP055500550, ISSN: 0036-8075, DOI: 10.1126/science.aaf7613
SILVANA KONERMANN ET AL: "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", NATURE, vol. 517, no. 7536, 10 December 2014 (2014-12-10), GB, pages 583 - 588, XP055294959, ISSN: 0028-0836, DOI: 10.1038/nature14136
Attorney, Agent or Firm:
TALAPATRA, Sunit et al. (US)
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