Title:
METHODS FOR THE IDENTIFICATION AND USE OF COMPOUNDS SUITABLE FOR THE TREATMENT OF DRUG RESISTANT CANCER CELLS
Document Type and Number:
WIPO Patent Application WO2006009765
Kind Code:
A3
Abstract:
The present invention relates to novel methods for the identification of compounds useful for the treatment of drug resistance, and to novel treatment methods using the identified compounds.
Inventors:
SZAKACS GERGELY (US)
ANNEREAU JEAN-PHILLIPE (FR)
LABABIDI SAMIR (US)
GOTTESMAN MICHAEL M (US)
WEINSTEIN JOHN (US)
ANNEREAU JEAN-PHILLIPE (FR)
LABABIDI SAMIR (US)
GOTTESMAN MICHAEL M (US)
WEINSTEIN JOHN (US)
Application Number:
PCT/US2005/021253
Publication Date:
May 11, 2006
Filing Date:
June 16, 2005
Export Citation:
Assignee:
US HEALTH (US)
SZAKACS GERGELY (US)
ANNEREAU JEAN-PHILLIPE (FR)
LABABIDI SAMIR (US)
GOTTESMAN MICHAEL M (US)
WEINSTEIN JOHN (US)
SZAKACS GERGELY (US)
ANNEREAU JEAN-PHILLIPE (FR)
LABABIDI SAMIR (US)
GOTTESMAN MICHAEL M (US)
WEINSTEIN JOHN (US)
International Classes:
G01N33/574
Domestic Patent References:
| WO2003037340A1 | 2003-05-08 |
Foreign References:
| US5968972A | 1999-10-19 |
Other References:
SCHINKEL A H ET AL: "Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.", CELL. 20 MAY 1994, vol. 77, no. 4, 20 May 1994 (1994-05-20), pages 491 - 502, XP002371482, ISSN: 0092-8674
XIAO ZHIYAN ET AL: "Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.", 23 May 2002, JOURNAL OF MEDICINAL CHEMISTRY. 23 MAY 2002, VOL. 45, NR. 11, PAGE(S) 2294 - 2309, ISSN: 0022-2623, XP002371514
GOTTESMAN M M ET AL: "THE MULTIDRUG TRANSPORTER A DOUBLE-EDGED SWORD", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 25, 1988, pages 12163 - 12166, XP002371483, ISSN: 0021-9258
XIAO ZHIYAN ET AL: "Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.", 23 May 2002, JOURNAL OF MEDICINAL CHEMISTRY. 23 MAY 2002, VOL. 45, NR. 11, PAGE(S) 2294 - 2309, ISSN: 0022-2623, XP002371514
GOTTESMAN M M ET AL: "THE MULTIDRUG TRANSPORTER A DOUBLE-EDGED SWORD", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 25, 1988, pages 12163 - 12166, XP002371483, ISSN: 0021-9258
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