Title:
METHODS FOR IDENTIFYING COMPOUNDS CAPABLE OF MODULATING CFTR/CK2 INTERACTION AND/OR CFTR PHOSPHORYLATION BY CK2
Document Type and Number:
WIPO Patent Application WO2006075172
Kind Code:
A3
Abstract:
A method of identifying a compound capable of modulating CFTR/CK2 interaction and/or CFTR phosphorylation by CK2 comprising exposing CFTR and/or CK2 to a test compound and assessing the effect of the test compound on CFTR/CK2 interaction and/or CFTR phosphorylation by CK2. A method of screening for compounds of use in preventing or treating a secretory state or disorder and/or a cancer and/or cystic fibrosis wherein CFTR and/or CK2 is exposed to a test compound and the effect of the test compound on CFTR/CK2 interaction and/or CFTR phosphorylation by CK2 is assessed.
Inventors:
MEHTA ANIL (GB)
CRAWFORD RUSSELL (GB)
TREHARNE KATHRYN (GB)
CRAWFORD RUSSELL (GB)
TREHARNE KATHRYN (GB)
Application Number:
PCT/GB2006/000122
Publication Date:
September 14, 2006
Filing Date:
January 13, 2006
Export Citation:
Assignee:
UNIV DUNDEE (GB)
MEHTA ANIL (GB)
CRAWFORD RUSSELL (GB)
TREHARNE KATHRYN (GB)
MEHTA ANIL (GB)
CRAWFORD RUSSELL (GB)
TREHARNE KATHRYN (GB)
International Classes:
G01N33/68; A61K48/00; A61P11/00; A61P35/00; C07K14/47; C07K14/705; C12N15/12
Domestic Patent References:
| WO2003087389A2 | 2003-10-23 | |||
| WO1992005273A1 | 1992-04-02 |
Foreign References:
| US20010041685A1 | 2001-11-15 | |||
| US6620795B1 | 2003-09-16 | |||
| US20040121968A1 | 2004-06-24 |
Other References:
SCOTT-WARD T S ET AL: "Direct block of the cystic fibrosis transmembrane conductance regulator Cl- channel by niflumic acid.", MOLECULAR MEMBRANE BIOLOGY, vol. 21, no. 1, 2004, pages 27 - 38, XP009066980, ISSN: 0968-7688
MENDES F ET AL: "Antibodies for CFTR studies", JOURNAL OF CYSTIC FIBROSIS, ELSEVIER, vol. 3, August 2004 (2004-08-01), pages 69 - 72, XP004556432, ISSN: 1569-1993
HOWELL L DANIEL ET AL: "ATP hydrolysis by a CFTR domain: Pharmacology and effects of G551D mutation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 271, no. 2, 10 May 2000 (2000-05-10), pages 518 - 525, XP002382630, ISSN: 0006-291X
MENDES F ET AL: "Antibodies for CFTR studies", JOURNAL OF CYSTIC FIBROSIS, ELSEVIER, vol. 3, August 2004 (2004-08-01), pages 69 - 72, XP004556432, ISSN: 1569-1993
HOWELL L DANIEL ET AL: "ATP hydrolysis by a CFTR domain: Pharmacology and effects of G551D mutation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 271, no. 2, 10 May 2000 (2000-05-10), pages 518 - 525, XP002382630, ISSN: 0006-291X
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