Title:
METHODS OF IDENTIFYING HCV NS5B POLYMERASE INHIBITORS AND USE AGAINST HEPATITIS C
Document Type and Number:
WIPO Patent Application WO2005000308
Kind Code:
A3
Abstract:
The present invention relates to a variety of screening methods, utilizing both biochemical and cellular assays as well as in silico assays, for use in the discovery of agents active in the treating or preventing Hepatitis C virus (HCV) infections. The invention also relates to methods of inhibiting an HCV NS5B polymerase and to the treatment and/or prevention of HCV infections with compounds having specified binding properties.
Inventors:
LU HENRY (US)
Application Number:
PCT/US2004/015665
Publication Date:
March 24, 2005
Filing Date:
May 17, 2004
Export Citation:
Assignee:
RIGEL PHARMACEUTICALS INC (US)
LU HENRY (US)
LU HENRY (US)
International Classes:
A61K31/4196; A61K31/4245; A61K31/433; A61K31/443; A61K31/4439; A61P31/12; G01N33/576; G16B15/30; G06F19/00; (IPC1-7): A61K31/443; A61K31/4439; A61P31/12
Domestic Patent References:
| WO2003040112A1 | 2003-05-15 | |||
| WO2004039970A1 | 2004-05-13 | |||
| WO2003002518A1 | 2003-01-09 |
Foreign References:
| US20030187000A1 | 2003-10-02 | |||
| US20030171874A1 | 2003-09-11 | |||
| US6322966B1 | 2001-11-27 |
Other References:
PERNI ROBERT B ET AL: "Inhibitors of hepatitis C virus NS3cntdot4A protease. Part 3: P2 proline variants", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 8, 19 April 2004 (2004-04-19), pages 1939 - 1942, XP008037248, ISSN: 0960-894X
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