Title:
METHODS FOR IDENTIFYING LIGANDS USING WATERLOGSY NMR
Document Type and Number:
WIPO Patent Application WO2003104824
Kind Code:
A3
Abstract:
A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a WaterLOGSY nuclear magnetic resonance spectrum of the reference compound in the presence of the target molecule; providing a test sample comprising at least one test compound; collecting a WaterLOGSY nuclear magnetic resonance spectrum of the reference compound in the presence of the test sample and the target molecule; and comparing the WaterLOGSY spectra to determine if at least one test compound interacts with the target molecule with a binding affinity tighter than that of the reference compound.
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Inventors:
DALVIT CLAUDIO (IT)
Application Number:
PCT/US2003/017739
Publication Date:
August 26, 2004
Filing Date:
June 05, 2003
Export Citation:
Assignee:
UPJOHN CO (US)
DALVIT CLAUDIO (IT)
DALVIT CLAUDIO (IT)
International Classes:
G01R33/32; G01N24/08; G01R33/465; (IPC1-7): G01N33/53
Foreign References:
| US6677160B1 | 2004-01-13 | |||
| US5459077A | 1995-10-17 |
Other References:
See also references of EP 1514108A4
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