METHODS FOR IDENTIFYING NOVEL MODULATORS OF INSULIN SIGNALING

Title:

METHODS FOR IDENTIFYING NOVEL MODULATORS OF INSULIN SIGNALING

Document Type and Number:

WIPO Patent Application WO2006052510

Kind Code:

A9

Abstract:

This invention provides novel cDNAs encoding G6PC expression regulators. The invention also provides methods of using the cDNAs to screen for compounds that modulate insulin signaling related activities such as gluconeogenesis and cell proliferation. The methods comprise first screening test compounds for modulators of a G6PC expression regulator that is encoded by the cDNAs, and then further screening the identified modulating compounds for modulators of insulin signaling related activities. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with abnormal insulin signaling.

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Inventors:

HUANG SHIH-MIN (US)
HANCOCK MICHAEL (US)
GEKAKIS NICHOLAS (US)
ORTH ANTHONY (US)

Application Number:

PCT/US2005/039304

Publication Date:

August 10, 2006

Filing Date:

October 28, 2005

Export Citation:

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Assignee:

IRM LLC (US)
HUANG SHIH-MIN (US)
HANCOCK MICHAEL (US)
GEKAKIS NICHOLAS (US)
ORTH ANTHONY (US)

International Classes:

A61F5/00

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