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Patent Searching and Data


Title:
METHODS FOR IDENTIFYING AND TREATING HIV PERSISTENCE
Document Type and Number:
WIPO Patent Application WO/2019/140147
Kind Code:
A1
Abstract:
Methods for identifying or monitoring or treating HIV persistence or the development of an HIV-comorbidity in an HIV+ subject involve certain selected glycan dysregulations. In certain embodiments, hyposialylation in the total IgG glycome or total plasma glycome of an HIV+ subject during or after antiretroviral therapy is an indication of HIV persistence and can be predictive of developing co-morbidities. Methods of treating HIV persistence or preventing developing co-morbidities involves modifying or manipulating the selected glycan by administering therapeutic agents that will modify the levels of the selected glycan, a precursor thereof, or another component of its pathway.

Inventors:
ABDEL-MOHSEN MOHAMED (US)
Application Number:
US2019/013128
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
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Assignee:
WISTAR INST (US)
International Classes:
A61K31/702; A61P37/00; C07H1/06; C07H3/00; C07H5/06; C08B37/00
Domestic Patent References:
WO2003093415A22003-11-13
WO2016149045A12016-09-22
Foreign References:
US6066323A2000-05-23
US20150233903A12015-08-20
US20170157160A12017-06-08
US20120276560A12012-11-01
US20110177090A12011-07-21
US20080071148A12008-03-20
US20120165206A12012-06-28
Other References:
ABDEL-MOHSEN ET AL.: "Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation", PLOS PATHOGENS, vol. 12, no. 6, 2 June 2016 (2016-06-02), pages 1 - 28, XP055506174
VADREVU ET AL.: "Frontline Science : Plasma and Immunoglobulin G Galactosylation Associate with HIV Persistence During Antiretroviral Therapy", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 104, no. 3, 6 April 2018 (2018-04-06), pages 461 - 471, XP055624583
PALMER ET AL.: "Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure", THE JOURNAL OF IMMUNOLOGY, vol. 196, no. 11, 1 June 2016 (2016-06-01), pages 4437 - 4444, XP055624585
VUCKOVIC ET AL.: "Association of Systemic Lupus Erythematosus with Decreased Immunosuppressive Potential of the IgG Glycome", ARTHRITIS & RHEUMATOLOGY, vol. 67, no. 11, 21 July 2015 (2015-07-21), pages 2978 - 2989, XP055624587
Attorney, Agent or Firm:
BAK, Mary, E. et al. (US)
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