Title:
METHODS FOR IMPROVING VACCINE RESPONSIVENESS
Document Type and Number:
WIPO Patent Application WO/2019/140370
Kind Code:
A1
Abstract:
The disclosure provides methods for immunizing a subject in need thereof with a prophylactic vaccine against an infectious disease, the method comprising enhancing the subject's immune responsiveness to the vaccine by administering to the subject an agent that transiently inhibits IL-10 production by follicular helper T ("Tfh") cells.
More Like This:
| WO/2003/087161 | MODIFIED FACTOR VIII |
| WO/2023/110045 | SCFV AND ANTIBODIES WITH REDUCED MULTIMERISATION |
| WO/2003/009784 | OPHTHALMIC DRUG DELIVERY DEVICE |
Inventors:
HILDEMAN DAVID (US)
ALMANAN MAHA (US)
CHOUGNET CLAIRE (US)
ALMANAN MAHA (US)
CHOUGNET CLAIRE (US)
Application Number:
PCT/US2019/013468
Publication Date:
July 18, 2019
Filing Date:
January 14, 2019
Export Citation:
Assignee:
CHILDRENS HOSPITAL MED CT (US)
International Classes:
A61K39/00; A61K39/395; A61P31/00; C07K16/24; C07K16/28
Domestic Patent References:
| WO2006108241A1 | 2006-10-19 |
Other References:
GUOYING NI ET AL: "Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice", BMC IMMUNOLOGY, vol. 18, no. 1, 15 August 2017 (2017-08-15), XP055582021, DOI: 10.1186/s12865-017-0224-x
O'GARRA ANNE ET AL: "Strategies for use of IL-10 or its antagonists in human disease", IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 223, no. 1, 31 May 2008 (2008-05-31), pages 114 - 131, XP009501784, ISSN: 0105-2896, DOI: 10.1111/J.1600-065X.2008.00635.X
J. M. PITT ET AL: "Blockade of IL-10 Signaling during Bacillus Calmette-Guerin Vaccination Enhances and Sustains Th1, Th17, and Innate Lymphoid IFN- and IL-17 Responses and Increases Protection to Mycobacterium tuberculosis Infection", THE JOURNAL OF IMMUNOLOGY, vol. 189, no. 8, 12 September 2012 (2012-09-12), US, pages 4079 - 4087, XP055582296, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1201061
PRADHAN PALLAB ET AL: "The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 35, no. 21, 8 April 2014 (2014-04-08), pages 5491 - 5504, XP028649160, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2014.03.039
MAHA A ALMANAN: "Type 1 regulatory T cells (Tr1) homeostasis and function in aging", THE JOURNAL OF IMMUNOLOGY, 1 May 2017 (2017-05-01), XP055582264, Retrieved from the Internet [retrieved on 20190418]
R. LAKSHMAN CHELVARAJAN ET AL: "The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 77, no. 4, 1 April 2005 (2005-04-01), US, pages 503 - 512, XP055582135, ISSN: 0741-5400, DOI: 10.1189/jlb.0804449
LEONIE BROCKMANN ET AL: "IL-10 Receptor Signaling Is Essential for T R 1 Cell Function In Vivo", THE JOURNAL OF IMMUNOLOGY, vol. 198, no. 3, 21 December 2016 (2016-12-21), US, pages 1130 - 1141, XP055582271, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1601045
JANA RAYNOR ET AL: "IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age", THE JOURNAL OF IMMUNOLOGY, vol. 195, no. 3, 24 June 2015 (2015-06-24), US, pages 944 - 952, XP055582272, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1500443
WEINBERGER, B., IMMUN. & AGEING, vol. 15, 2018, pages 3 - 10
LUSTIG, A. ET AL., FRONTIERS IMMUN., vol. 8, 2017, pages 1027
LIO, D. ET AL., GENES IMMUN., vol. 3, 2002, pages 30 - 33
LIO, D. ET AL., J. MED.GENET., vol. 41, 2004, pages 790 - 794
CAULEY, J. ET AL., J. BONE MINER. RES., vol. 31, 2016, pages 2129 - 2138
BELKAID, Y. ET AL., J. EXP. MED., vol. 194, 2001, pages 1497 - 1506
BROOKS, D. ET AL., NATURE MED., vol. 12, 2006, pages 1301 - 1309
BROOKS, D. ET AL., J. EXP. MED., vol. 205, 2008, pages 533 - 541
MCKINSTRY, K. ET AL., J. IMMUNOL., vol. 182, 2009, pages 7353 - 7363
DOBBER, R. ET AL., CELL IMMUNOL., vol. 160, 1995, pages 185 - 192
MOORE, K. ET AL., ANN. REV. IMMUNOL., vol. 19, 2001, pages 683 - 765
MADAN, R. ET AL., J. IMMUNOL., vol. 183, 2009, pages 2312 - 2320
VAN DER GEEST, K. ET AL., EXP. GERONTOL., vol. 75, 2016, pages 24 - 29
GAUTAM ET AL., J. DRUG DELIVERY SCI. TECH., 2017, pages 260 - 268
PEER ET AL., SCIENCE, vol. 319, no. 5863, 2008, pages 627 - 30
BOBBIN; ROSSI, ANNU REV. PHARMACOL TOXICOL, vol. 56, 2016, pages 103 - 122
RAYNOR, J. ET AL., CURR. OPIN. IMMUNOL., vol. 24, 2012, pages 482 - 487
KIM, J. ET AL., NATURE IMMUNOL., vol. 8, 2007, pages 191 - 197
MAZMANIAN, S. ET AL., NATURE, vol. 453, 2008, pages 620 - 625
ROUND, J. ET AL., PNAS (USA, vol. 107, 2010, pages 12204 - 12209
THEVARANJAN, N. ET AL., CELL HOST MICROBE, vol. 21, 2017, pages 455 - 466
GAGLIANI, N. ET AL., NATURE, vol. 523, 2015, pages 221 - 225
RONCAROLO, M. ET AL., CURR. TOPICS MICROBIOL. IMMUNOL., vol. 380, 2014, pages 39 - 68
WANG, Z. ET AL., J. IMMUNOL., vol. 174, 2005, pages 2098 - 2105
GAGLIANI, N. ET AL., NATURE MED., vol. 19, 2013, pages 739 - 746
HIROTA, K. ET AL., NAT. IMMUNOL., vol. 12, 2011, pages 255 - 263
ZHOU, X. ET AL., J. EXP. MED., vol. 205, 2008, pages 1983 - 1991
MADISEN, L. ET AL., NAT. NEUROSCI., vol. 13, 2010, pages 133 - 140
HAYNES, N. ET AL., J. IMMUNOL., vol. 179, 2007, pages 5099 - 5108
JOHNSTON, R. ET AL., SCIENCE, vol. 325, 2009, pages 1006 - 1010
NURIEVA, R. ET AL., NATURE, vol. 448, 2007, pages 480 - 483
VOGELZANG, A. ET AL., IMMUNITY, vol. 29, 2008, pages 127 - 137
AKIBA, H. ET AL., J. IMMUNOL., vol. 175, 2005, pages 2340 - 2348
CHOUGNET, C. ET AL., J. IMMUNOL., vol. 186, 2011, pages 156 - 163
TSUKAMOTO, H. ET AL., J. IMMUNOL., vol. 185, 2010, pages 4535 - 4544
HOLLISTER, K. ET AL., J. IMMUNOL., vol. 191, 2013, pages 3705 - 3711
YU, D. ET AL., IMMUNITY, vol. 31, 2009, pages 457 - 468
NEUMANN, C. ET AL., J. EXP.MED., vol. 211, 2014, pages 1807 - 1819
NEUMANN, C. ET AL., J. EXP. MED., vol. 211, 2014, pages 1807 - 1819
XIE, M. ET AL., EUR. J. IMMUNOL., vol. 47, 2017, pages 1136 - 1141
KIM, J. ET AL., NAT. IMMUNOL., vol. 8, 2007, pages 191 - 197
FINKELMAN, F. ET AL.: "Curr. Prot. Immunol.", 2003
O'GARRA ANNE ET AL: "Strategies for use of IL-10 or its antagonists in human disease", IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 223, no. 1, 31 May 2008 (2008-05-31), pages 114 - 131, XP009501784, ISSN: 0105-2896, DOI: 10.1111/J.1600-065X.2008.00635.X
J. M. PITT ET AL: "Blockade of IL-10 Signaling during Bacillus Calmette-Guerin Vaccination Enhances and Sustains Th1, Th17, and Innate Lymphoid IFN- and IL-17 Responses and Increases Protection to Mycobacterium tuberculosis Infection", THE JOURNAL OF IMMUNOLOGY, vol. 189, no. 8, 12 September 2012 (2012-09-12), US, pages 4079 - 4087, XP055582296, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1201061
PRADHAN PALLAB ET AL: "The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 35, no. 21, 8 April 2014 (2014-04-08), pages 5491 - 5504, XP028649160, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2014.03.039
MAHA A ALMANAN: "Type 1 regulatory T cells (Tr1) homeostasis and function in aging", THE JOURNAL OF IMMUNOLOGY, 1 May 2017 (2017-05-01), XP055582264, Retrieved from the Internet
R. LAKSHMAN CHELVARAJAN ET AL: "The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 77, no. 4, 1 April 2005 (2005-04-01), US, pages 503 - 512, XP055582135, ISSN: 0741-5400, DOI: 10.1189/jlb.0804449
LEONIE BROCKMANN ET AL: "IL-10 Receptor Signaling Is Essential for T R 1 Cell Function In Vivo", THE JOURNAL OF IMMUNOLOGY, vol. 198, no. 3, 21 December 2016 (2016-12-21), US, pages 1130 - 1141, XP055582271, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1601045
JANA RAYNOR ET AL: "IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age", THE JOURNAL OF IMMUNOLOGY, vol. 195, no. 3, 24 June 2015 (2015-06-24), US, pages 944 - 952, XP055582272, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1500443
WEINBERGER, B., IMMUN. & AGEING, vol. 15, 2018, pages 3 - 10
LUSTIG, A. ET AL., FRONTIERS IMMUN., vol. 8, 2017, pages 1027
LIO, D. ET AL., GENES IMMUN., vol. 3, 2002, pages 30 - 33
LIO, D. ET AL., J. MED.GENET., vol. 41, 2004, pages 790 - 794
CAULEY, J. ET AL., J. BONE MINER. RES., vol. 31, 2016, pages 2129 - 2138
BELKAID, Y. ET AL., J. EXP. MED., vol. 194, 2001, pages 1497 - 1506
BROOKS, D. ET AL., NATURE MED., vol. 12, 2006, pages 1301 - 1309
BROOKS, D. ET AL., J. EXP. MED., vol. 205, 2008, pages 533 - 541
MCKINSTRY, K. ET AL., J. IMMUNOL., vol. 182, 2009, pages 7353 - 7363
DOBBER, R. ET AL., CELL IMMUNOL., vol. 160, 1995, pages 185 - 192
MOORE, K. ET AL., ANN. REV. IMMUNOL., vol. 19, 2001, pages 683 - 765
MADAN, R. ET AL., J. IMMUNOL., vol. 183, 2009, pages 2312 - 2320
VAN DER GEEST, K. ET AL., EXP. GERONTOL., vol. 75, 2016, pages 24 - 29
GAUTAM ET AL., J. DRUG DELIVERY SCI. TECH., 2017, pages 260 - 268
PEER ET AL., SCIENCE, vol. 319, no. 5863, 2008, pages 627 - 30
BOBBIN; ROSSI, ANNU REV. PHARMACOL TOXICOL, vol. 56, 2016, pages 103 - 122
RAYNOR, J. ET AL., CURR. OPIN. IMMUNOL., vol. 24, 2012, pages 482 - 487
KIM, J. ET AL., NATURE IMMUNOL., vol. 8, 2007, pages 191 - 197
MAZMANIAN, S. ET AL., NATURE, vol. 453, 2008, pages 620 - 625
ROUND, J. ET AL., PNAS (USA, vol. 107, 2010, pages 12204 - 12209
THEVARANJAN, N. ET AL., CELL HOST MICROBE, vol. 21, 2017, pages 455 - 466
GAGLIANI, N. ET AL., NATURE, vol. 523, 2015, pages 221 - 225
RONCAROLO, M. ET AL., CURR. TOPICS MICROBIOL. IMMUNOL., vol. 380, 2014, pages 39 - 68
WANG, Z. ET AL., J. IMMUNOL., vol. 174, 2005, pages 2098 - 2105
GAGLIANI, N. ET AL., NATURE MED., vol. 19, 2013, pages 739 - 746
HIROTA, K. ET AL., NAT. IMMUNOL., vol. 12, 2011, pages 255 - 263
ZHOU, X. ET AL., J. EXP. MED., vol. 205, 2008, pages 1983 - 1991
MADISEN, L. ET AL., NAT. NEUROSCI., vol. 13, 2010, pages 133 - 140
HAYNES, N. ET AL., J. IMMUNOL., vol. 179, 2007, pages 5099 - 5108
JOHNSTON, R. ET AL., SCIENCE, vol. 325, 2009, pages 1006 - 1010
NURIEVA, R. ET AL., NATURE, vol. 448, 2007, pages 480 - 483
VOGELZANG, A. ET AL., IMMUNITY, vol. 29, 2008, pages 127 - 137
AKIBA, H. ET AL., J. IMMUNOL., vol. 175, 2005, pages 2340 - 2348
CHOUGNET, C. ET AL., J. IMMUNOL., vol. 186, 2011, pages 156 - 163
TSUKAMOTO, H. ET AL., J. IMMUNOL., vol. 185, 2010, pages 4535 - 4544
HOLLISTER, K. ET AL., J. IMMUNOL., vol. 191, 2013, pages 3705 - 3711
YU, D. ET AL., IMMUNITY, vol. 31, 2009, pages 457 - 468
NEUMANN, C. ET AL., J. EXP.MED., vol. 211, 2014, pages 1807 - 1819
NEUMANN, C. ET AL., J. EXP. MED., vol. 211, 2014, pages 1807 - 1819
XIE, M. ET AL., EUR. J. IMMUNOL., vol. 47, 2017, pages 1136 - 1141
KIM, J. ET AL., NAT. IMMUNOL., vol. 8, 2007, pages 191 - 197
FINKELMAN, F. ET AL.: "Curr. Prot. Immunol.", 2003
Attorney, Agent or Firm:
LIBERTO, Muriel et al. (US)
Download PDF:
Previous Patent: RUBBER COMPOSITIONS WITH DISSAGGREGATED CARBON NANOTUBES
Next Patent: PRE-LOADED PIEZOELECTRIC STACK ACTUATOR
Next Patent: PRE-LOADED PIEZOELECTRIC STACK ACTUATOR