METHODS FOR THE INDENTIFICATION OF INHIBITORS OF HISTIDINOL DEHYDROGENASE AS ANTIBIOTICS

Title:

METHODS FOR THE INDENTIFICATION OF INHIBITORS OF HISTIDINOL DEHYDROGENASE AS ANTIBIOTICS

Document Type and Number:

WIPO Patent Application WO2005089156

Kind Code:

A3

Abstract:

The present inventors have discovered that a histidinol dehydrogenase (HIS4) is essential for normal fungal pathogenicity. Specifically, the inhibition of HIS4 gene expression in Magnaportha grisea

Inventors:

TANZER MATTHEW M (US)
SHUSTER JEFFREY R (US)
HAMER LISBETH (US)
ADACHI KIICHI (JP)
DEZWAAN TODD M (US)
LO SZE-CHUNG C (CN)
MONTENEGRO-CHAMORRO MARIA VICT (US)
DARVEAUX BLAISE A (US)
FRANK SHERYL A (US)
HEINIGER RYAN W (US)
MAHANTY SANJOY K (US)
PAN HUAQIN (US)
COVINGTON AMY S (US)
TARPEY REX (US)

Application Number:

PCT/US2005/007632

Publication Date:

January 05, 2006

Filing Date:

March 10, 2005

Export Citation:

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Assignee:

ICORIA INC (US)
TANZER MATTHEW M (US)
SHUSTER JEFFREY R (US)
HAMER LISBETH (US)
ADACHI KIICHI (JP)
DEZWAAN TODD M (US)
LO SZE-CHUNG C (CN)
MONTENEGRO-CHAMORRO MARIA VICT (US)
DARVEAUX BLAISE A (US)
FRANK SHERYL A (US)
HEINIGER RYAN W (US)
MAHANTY SANJOY K (US)
PAN HUAQIN (US)
COVINGTON AMY S (US)
TARPEY REX (US)

International Classes:

C12Q1/18; C12Q1/32; C12Q1/68; G01N33/53; G01N33/569; (IPC1-7): C12Q1/68; G01N33/53; G01N33/569

Foreign References:

US20050142113A1	2005-06-30
US20040122212A1	2004-06-24
US6348582B1	2002-02-19

Other References:

DATABASE GENBANK [online] 23 December 2003 (2003-12-23), XP002990796, Database accession no. (XM_363383)

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