Title:
METHODS FOR INDUCING APOLIPOPROTEIN E SECRETION
Document Type and Number:
WIPO Patent Application WO2002011708
Kind Code:
A3
Abstract:
The invention provides a method for increasing apolipoprotein E (ApoE) in plasma and in tissues of a mammal by using a combination of an ApoE increasing amount of an activator of the orphan nuclear receptor FXR and an ApoE increasing amount of an activator of the orphan nuclear receptor LXR alpha . Also provided is the use of a combination of an ApoE increasing amount of a FXR activator and of an ApoE increasing amount of a LXR alpha activator, for the manufacture of a medicament for increasing ApoE in plasma and in tissues of a mammal.
Inventors:
NIESOR ERIC J (CH)
PEREZ ANE (CH)
THUILLARD JEAN-LUC (CH)
BENTZEN CRAIG L (CH)
NGUYEN LAN MONG (CH)
PEREZ ANE (CH)
THUILLARD JEAN-LUC (CH)
BENTZEN CRAIG L (CH)
NGUYEN LAN MONG (CH)
Application Number:
PCT/EP2001/008980
Publication Date:
March 13, 2003
Filing Date:
August 02, 2001
Export Citation:
Assignee:
SYMPHAR SA (CH)
NIESOR ERIC J (CH)
PEREZ ANE (CH)
THUILLARD JEAN-LUC (CH)
BENTZEN CRAIG L (CH)
NGUYEN LAN MONG (CH)
NIESOR ERIC J (CH)
PEREZ ANE (CH)
THUILLARD JEAN-LUC (CH)
BENTZEN CRAIG L (CH)
NGUYEN LAN MONG (CH)
International Classes:
A61K31/045; A61K31/08; A61K31/232; A61K31/335; A61K31/336; A61K31/575; G01N33/50; A61K31/58; A61K45/00; A61K45/06; A61P3/00; A61P3/10; A61P25/00; A61P25/20; A61P25/28; A61P27/02; G01N33/15; G01N33/53; (IPC1-7): A61K31/575; A61P3/00
Domestic Patent References:
| WO2001015676A2 | 2001-03-08 |
Foreign References:
| US5475029A | 1995-12-12 |
Other References:
CARLSON T L ET AL: "Effect of 25- hydroxycholesterol and bile acids on the regulatio of cholesterol metabolism in Hep G2 cells.", BIOCHEMICAL JOURNAL, (1989 NOV 15) 264 (1) 241-7., XP008006543
JANOWSKI ET AL: "Structural requirements of ligands for the oxysterol liver X receptors LXR.alpha. and LXR.beta", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 1, 5 January 1999 (1999-01-05), pages 266 - 271, XP002104645, ISSN: 0027-8424
JANOWSKI ET AL: "Structural requirements of ligands for the oxysterol liver X receptors LXR.alpha. and LXR.beta", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 1, 5 January 1999 (1999-01-05), pages 266 - 271, XP002104645, ISSN: 0027-8424
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