Title:
METHODS OF INDUCING OR ENHANCING CONNECTIVE TISSUE REPAIR
Document Type and Number:
WIPO Patent Application WO2003059932
Kind Code:
A3
Abstract:
This invention provides a nucleic acid encoding SMAD protein variant, cells which express SMAD protein variant.. This invention further provides SMAD-8 protein variant and nucleic acid which encodes for the SMAD-8 variant. Lastly, the invention provides methods of ex-vivo implantation of cells, including mesenchymal stem cells, progenitor cells, cells derived from a ligament or a tendon of a subject in need or any other cell that can engraft into ligament and tendon and differentiate to tendocyte/ligament cell, which are further engineered to express Variant SMAD proteinor the SMAD-8 protein variant.
Inventors:
GAZIT DAN (IL)
PELLED GADI (IL)
TURGEMAN GADI (IL)
HOFFMANN ANDREA (DE)
EBERLE PETER (DE)
GROSS GERHARD (DE)
PELLED GADI (IL)
TURGEMAN GADI (IL)
HOFFMANN ANDREA (DE)
EBERLE PETER (DE)
GROSS GERHARD (DE)
Application Number:
PCT/IL2002/001041
Publication Date:
January 29, 2004
Filing Date:
December 26, 2002
Export Citation:
Assignee:
YISSUM RES DEV CO (IL)
BIOTECHNOLOG FORSCHUNG GMBH (DE)
GAZIT DAN (IL)
PELLED GADI (IL)
TURGEMAN GADI (IL)
HOFFMANN ANDREA (DE)
EBERLE PETER (DE)
GROSS GERHARD (DE)
BIOTECHNOLOG FORSCHUNG GMBH (DE)
GAZIT DAN (IL)
PELLED GADI (IL)
TURGEMAN GADI (IL)
HOFFMANN ANDREA (DE)
EBERLE PETER (DE)
GROSS GERHARD (DE)
International Classes:
A61K35/28; A61K35/76; A61K38/00; A61K48/00; C12N15/09; A61L27/00; A61P19/04; C07K14/47; C12N5/0775; C12N5/10; A61K35/12; (IPC1-7): A01N63/00; A61K48/00; C07H21/00; C07H21/02; C07H21/04
Foreign References:
| JPH10117782A | 1998-05-12 |
Other References:
REDDI: "Bone morphogenetic proteins, tissue engineering and regeneration", INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 45, no. SUPP. 1, 2001, pages S31, XP002968040
CHEN ET AL.: "Smad8 mediates the signaling of the receptor serine kinase", PROC. NATL. ACAD. SCI. USA, vol. 94, November 1997 (1997-11-01), pages 12938 - 12943, XP002968041
HOFFMANN ET AL.: "Perspectives in the biological function, the technical and therapeutic application of bone morphogenetic proteins", APPL. MICROBIOL. BIOTECHNOL., vol. 57, 2001, pages 294 - 308, XP002968042
CHEN ET AL.: "Smad8 mediates the signaling of the receptor serine kinase", PROC. NATL. ACAD. SCI. USA, vol. 94, November 1997 (1997-11-01), pages 12938 - 12943, XP002968041
HOFFMANN ET AL.: "Perspectives in the biological function, the technical and therapeutic application of bone morphogenetic proteins", APPL. MICROBIOL. BIOTECHNOL., vol. 57, 2001, pages 294 - 308, XP002968042
Download PDF:
Previous Patent: PROCESS FOR THE PREPARATION OF 7&agr −METHYLSTEROIDS
Next Patent: CONFORMATIONALLY CONSTRAINED C-BACKBONE CYCLIC PEPTIDES
Next Patent: CONFORMATIONALLY CONSTRAINED C-BACKBONE CYCLIC PEPTIDES