Title:
METHODS FOR INDUCING MIXED CHIMERISM
Document Type and Number:
WIPO Patent Application WO/2010/062966
Kind Code:
A3
Abstract:
Fusion protein-siRNA complexes that specifically target activated T cells, and methods of use thereof, are described.
Inventors:
LUCAS CARRIE (US)
SYKES MEGAN (US)
LIEBERMAN JUDITH (US)
SCHLESINGER ANN (US)
SHIMAOKA MOTOMU (US)
SYKES MEGAN (US)
LIEBERMAN JUDITH (US)
SCHLESINGER ANN (US)
SHIMAOKA MOTOMU (US)
Application Number:
PCT/US2009/065945
Publication Date:
October 14, 2010
Filing Date:
November 25, 2009
Export Citation:
Assignee:
GEN HOSPITAL CORP (US)
IMMUNE DISEASE INST (US)
LUCAS CARRIE (US)
SYKES MEGAN (US)
LIEBERMAN JUDITH (US)
SCHLESINGER ANN (US)
SHIMAOKA MOTOMU (US)
IMMUNE DISEASE INST (US)
LUCAS CARRIE (US)
SYKES MEGAN (US)
LIEBERMAN JUDITH (US)
SCHLESINGER ANN (US)
SHIMAOKA MOTOMU (US)
International Classes:
C12N15/11; A61K31/7105; A61K39/00; A61K48/00; C07K19/00; C12N5/0783
Foreign References:
| US20060240024A1 | 2006-10-26 | |||
| US20070009517A1 | 2007-01-11 |
Other References:
DAN PEER ET AL.: "Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1", PNAS, vol. 104, no. 10, 6 March 2007 (2007-03-06), pages 4095 - 4100
DAN PEER ET AL.: "Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti- Inflammatory Target", SCIENCE, vol. 319, 1 February 2008 (2008-02-01), pages 627 - 630
PRITI KUMAR ET AL.: "T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice", CELL, vol. 134, 22 August 2008 (2008-08-22), pages 577 - 586
TATIANA I. NOVOBRANTSEVA ET AL.: "Delivering silence: advancements in developing siRNA therapeutics", CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, vol. 11, no. 2, 31 March 2008 (2008-03-31), pages 217 - 224
MARIA SANDOVICI ET AL.: "Immune modulation and graft protection by gene therapy in kidney trans- plantation", EUROPEAN J OF PHARMACOLOGY, vol. 585, 15 March 2008 (2008-03-15), pages 261 - 269
TATJANA C. GUST ET AL.: "RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes", CELL COMMUNICATION AND SIGNALING, vol. 6, 6 August 2008 (2008-08-06), pages 3
S KAWAKAMI ET AL.: "Targeted Delivery Systems of Small Interfering RNA by Systemic Administration", DRUG METAB PHARMACOKINET, vol. 22, no. 3, 31 December 2007 (2007-12-31), pages 142 - 151
DAN PEER ET AL.: "Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti- Inflammatory Target", SCIENCE, vol. 319, 1 February 2008 (2008-02-01), pages 627 - 630
PRITI KUMAR ET AL.: "T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice", CELL, vol. 134, 22 August 2008 (2008-08-22), pages 577 - 586
TATIANA I. NOVOBRANTSEVA ET AL.: "Delivering silence: advancements in developing siRNA therapeutics", CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, vol. 11, no. 2, 31 March 2008 (2008-03-31), pages 217 - 224
MARIA SANDOVICI ET AL.: "Immune modulation and graft protection by gene therapy in kidney trans- plantation", EUROPEAN J OF PHARMACOLOGY, vol. 585, 15 March 2008 (2008-03-15), pages 261 - 269
TATJANA C. GUST ET AL.: "RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes", CELL COMMUNICATION AND SIGNALING, vol. 6, 6 August 2008 (2008-08-06), pages 3
S KAWAKAMI ET AL.: "Targeted Delivery Systems of Small Interfering RNA by Systemic Administration", DRUG METAB PHARMACOKINET, vol. 22, no. 3, 31 December 2007 (2007-12-31), pages 142 - 151
Attorney, Agent or Firm:
KUGLER DEYOUNG, Janice et al. (P.O. Box 1022Minneapolis, Minnesota, US)
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