Title:
METHODS OF INHIBITING CELL PROLIFERATION AND METTL8 ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2019/009813
Kind Code:
A3
Abstract:
The disclosure provides a method of inhibiting proliferation of a cell, inhibiting m3C formation in a cell, inhibiting activity of Mettl8 in a cell, or activating ATM and p53 in a cell, the method comprising contacting the cell with a Mettl8 inhibitor. The disclosure also provides a composition comprising a cell with a reduced expression or activity of Mettl8. In another aspect, the disclosure provides methods of rendering a tumor cell sensitive to a cancer therapy.
Inventors:
FU XIN-YUAN (SG)
LIU XINYU (SG)
XU LU ANG (SG)
LIU XINYU (SG)
XU LU ANG (SG)
Application Number:
PCT/SG2018/050337
Publication Date:
January 31, 2019
Filing Date:
July 06, 2018
Export Citation:
Assignee:
NAT UNIV SINGAPORE (SG)
International Classes:
C12N15/113; A61K31/7088; A61P35/00; C12N15/10
Other References:
LUANG XU ET AL: "Three distinct 3-methylcytidine (m 3 C) methyltransferases modify tRNA and mRNA in mice and humans", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 292, no. 35, 27 June 2017 (2017-06-27), US, pages 14695 - 14703, XP055516018, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.798298
JUNXIN LIANG: "FUNCTIONAL CHARACTERIZATION OF HUMAN METHYLTRANSFERASE LIKE PROTEIN 8 IN DNA DAMAGE RESPONSE", PH. D. THESIS, 22 January 2014 (2014-01-22), XP055516063, Retrieved from the Internet [retrieved on 20181016]
STEFFANIE L. FURTEK ET AL: "Strategies and Approaches of Targeting STAT3 for Cancer Treatment", ACS CHEMICAL BIOLOGY, vol. 11, no. 2, 5 January 2016 (2016-01-05), pages 308 - 318, XP055516323, ISSN: 1554-8929, DOI: 10.1021/acschembio.5b00945
XIANG GAO: "BIOCHEMICAL CHARACTERIZATION OF A NOVEL NUCLEAR METHYLTRANSFERASE COMPLEX", PH. D. THESIS, 30 December 2014 (2014-12-30), XP055516880, Retrieved from the Internet [retrieved on 20181018]
SARAH E HENSON ET AL: "Candidate genes contributing to the aggressive phenotype of mantle cell lymphoma", ACTA HISTOCHEMICA, ELSEVIER, AMSTERDAM, NL, vol. 113, no. 7, 9 December 2010 (2010-12-09), pages 729 - 742, XP028241560, ISSN: 0065-1281, [retrieved on 20101117], DOI: 10.1016/J.ACTHIS.2010.11.001
MOHAMMAD ZAHID KAMRAN ET AL: "Role of STAT3 in Cancer Metastasis and Translational Advances", BIOMED RESEARCH INTERNATIONAL, vol. 2013, 2013, pages 1 - 15, XP055516324, ISSN: 2314-6133, DOI: 10.1155/2013/421821
HAO GU ET AL: "The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway", STEM CELL REPORTS, vol. 10, no. 6, 26 April 2018 (2018-04-26), United States, pages 1807 - 1820, XP055516047, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.03.022
JUNXIN LIANG: "FUNCTIONAL CHARACTERIZATION OF HUMAN METHYLTRANSFERASE LIKE PROTEIN 8 IN DNA DAMAGE RESPONSE", PH. D. THESIS, 22 January 2014 (2014-01-22), XP055516063, Retrieved from the Internet
STEFFANIE L. FURTEK ET AL: "Strategies and Approaches of Targeting STAT3 for Cancer Treatment", ACS CHEMICAL BIOLOGY, vol. 11, no. 2, 5 January 2016 (2016-01-05), pages 308 - 318, XP055516323, ISSN: 1554-8929, DOI: 10.1021/acschembio.5b00945
XIANG GAO: "BIOCHEMICAL CHARACTERIZATION OF A NOVEL NUCLEAR METHYLTRANSFERASE COMPLEX", PH. D. THESIS, 30 December 2014 (2014-12-30), XP055516880, Retrieved from the Internet
SARAH E HENSON ET AL: "Candidate genes contributing to the aggressive phenotype of mantle cell lymphoma", ACTA HISTOCHEMICA, ELSEVIER, AMSTERDAM, NL, vol. 113, no. 7, 9 December 2010 (2010-12-09), pages 729 - 742, XP028241560, ISSN: 0065-1281, [retrieved on 20101117], DOI: 10.1016/J.ACTHIS.2010.11.001
MOHAMMAD ZAHID KAMRAN ET AL: "Role of STAT3 in Cancer Metastasis and Translational Advances", BIOMED RESEARCH INTERNATIONAL, vol. 2013, 2013, pages 1 - 15, XP055516324, ISSN: 2314-6133, DOI: 10.1155/2013/421821
HAO GU ET AL: "The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway", STEM CELL REPORTS, vol. 10, no. 6, 26 April 2018 (2018-04-26), United States, pages 1807 - 1820, XP055516047, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.03.022
Attorney, Agent or Firm:
KALANI, Ameen (SG)
Download PDF: