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Title:
METHODS OF INHIBITING CELL PROLIFERATION AND METTL8 ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2019/009813
Kind Code:
A3
Abstract:
The disclosure provides a method of inhibiting proliferation of a cell, inhibiting m3C formation in a cell, inhibiting activity of Mettl8 in a cell, or activating ATM and p53 in a cell, the method comprising contacting the cell with a Mettl8 inhibitor. The disclosure also provides a composition comprising a cell with a reduced expression or activity of Mettl8. In another aspect, the disclosure provides methods of rendering a tumor cell sensitive to a cancer therapy.

Inventors:
FU, Xin-Yuan (Cancer Science Institute of Singapore21 Lower Kent Ridge Road, Singapore 7, 119077, SG)
LIU, Xinyu (Cancer Science Institute of Singapore21 Lower Kent Ridge Road, Singapore 7, 119077, SG)
XU, Lu Ang (Cancer Science Institute of Singapore21 Lower Kent Ridge Road, Singapore 7, 119077, SG)
Application Number:
SG2018/050337
Publication Date:
January 31, 2019
Filing Date:
July 06, 2018
Export Citation:
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Assignee:
NATIONAL UNIVERSITY OF SINGAPORE (21 Lower Kent Ridge Road, Singapore 7, 119077, SG)
International Classes:
C12N15/113; A61K31/7088; A61P35/00; C12N15/10
Other References:
LUANG XU ET AL: "Three distinct 3-methylcytidine (m 3 C) methyltransferases modify tRNA and mRNA in mice and humans", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 292, no. 35, 27 June 2017 (2017-06-27), US, pages 14695 - 14703, XP055516018, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.798298
JUNXIN LIANG: "FUNCTIONAL CHARACTERIZATION OF HUMAN METHYLTRANSFERASE LIKE PROTEIN 8 IN DNA DAMAGE RESPONSE", PH. D. THESIS, 22 January 2014 (2014-01-22), XP055516063, Retrieved from the Internet [retrieved on 20181016]
STEFFANIE L. FURTEK ET AL: "Strategies and Approaches of Targeting STAT3 for Cancer Treatment", ACS CHEMICAL BIOLOGY, vol. 11, no. 2, 5 January 2016 (2016-01-05), pages 308 - 318, XP055516323, ISSN: 1554-8929, DOI: 10.1021/acschembio.5b00945
XIANG GAO: "BIOCHEMICAL CHARACTERIZATION OF A NOVEL NUCLEAR METHYLTRANSFERASE COMPLEX", PH. D. THESIS, 30 December 2014 (2014-12-30), XP055516880, Retrieved from the Internet [retrieved on 20181018]
SARAH E HENSON ET AL: "Candidate genes contributing to the aggressive phenotype of mantle cell lymphoma", ACTA HISTOCHEMICA, ELSEVIER, AMSTERDAM, NL, vol. 113, no. 7, 9 December 2010 (2010-12-09), pages 729 - 742, XP028241560, ISSN: 0065-1281, [retrieved on 20101117], DOI: 10.1016/J.ACTHIS.2010.11.001
MOHAMMAD ZAHID KAMRAN ET AL: "Role of STAT3 in Cancer Metastasis and Translational Advances", BIOMED RESEARCH INTERNATIONAL, vol. 2013, 2013, pages 1 - 15, XP055516324, ISSN: 2314-6133, DOI: 10.1155/2013/421821
HAO GU ET AL: "The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway", STEM CELL REPORTS, vol. 10, no. 6, 26 April 2018 (2018-04-26), United States, pages 1807 - 1820, XP055516047, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.03.022
Attorney, Agent or Firm:
KALANI, Ameen (Henry Goh Pte Ltd, 2 Venture Drive#15-21 Vision Exchange, Singapore 6, 117674, SG)
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