Title:
METHODS OF INHIBITING GLIAL SCAR FORMATION
Document Type and Number:
WIPO Patent Application WO2004041197
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for inhibiting glial scar formation, methods and compositions for decreasing GAG content, methods and composition for decreasing proteoglycan gene expression, and methods and compositions for promoting neuronal regeneration. The present invention further provides methods of identifying additional agents that inhibit glial scar formation and/or promote neuronal regeneration.
Inventors:
GRIMPE BARBARA (US)
SILVER JERRY (US)
SILVER JERRY (US)
Application Number:
PCT/US2003/034806
Publication Date:
April 07, 2005
Filing Date:
October 31, 2003
Export Citation:
Assignee:
UNIV CASE WESTERN RESERVE (US)
GRIMPE BARBARA (US)
SILVER JERRY (US)
GRIMPE BARBARA (US)
SILVER JERRY (US)
International Classes:
A61K31/70; A61K48/00; C12N15/113; (IPC1-7): A01N43/04; A61K31/70; C07H21/04; C12N5/00
Domestic Patent References:
| WO2000073509A2 | 2000-12-07 |
Other References:
TAYLOR ET AL.: "Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination", DDT, vol. 4, no. 12, 12 December 1999 (1999-12-12), pages 562 - 567, XP002952061
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