METHODS OF INHIBITING RESTENOSIS

Title:

METHODS OF INHIBITING RESTENOSIS

Document Type and Number:

WIPO Patent Application WO/1993/009790

Kind Code:

A1

Abstract:

Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.

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Inventors:

HERRMANN HOWARD C (US)
BARNATHAN ELLIOT (US)
WEISZ PAUL B (US)

Application Number:

PCT/US1992/009754

Publication Date:

May 27, 1993

Filing Date:

November 10, 1992

Export Citation:

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Assignee:

UNIV PENNSYLVANIA (US)

International Classes:

A61K31/715; A61K31/335; A61K31/395; A61K31/57; A61K31/724; A61K31/737; A61K38/18; A61K47/48; A61L15/28; A61L26/00; A61L27/20; A61L27/34; A61L27/36; A61L27/54; A61L33/00; A61P43/00; C07K14/50; C08B37/16; (IPC1-7): A61K31/56; A61K31/70; A61K31/715; A61K31/735

Domestic Patent References:

WO1987005808A1

1987-10-08

Foreign References:

US4020160A	1977-04-26
EP0325199A2	1989-07-26

Other References:

Science, Vol. 230, issued 20 December 1985, R. CRUM, "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment", pages 1376-1378, entire document.
Science, Vol. 243, issued 17 March 1989, J. FOLKMAN et al., "Control of Angiogenesis with Synthetic Heparin Substitutes", pages 1490-1493, entire document.
See also references of EP 0612249A4

Attorney, Agent or Firm:

Navon, Jeffrey N. (2600 One Reading Center, 1101 Market Street, Philadelphia, PA, US)

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