Title:
METHODS FOR INHIBITING SMOOTH MUSCLE CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2001055176
Kind Code:
A3
Abstract:
The present invention provides improved methods and pharmaceutical compositions for inhibiting smooth muscle cell proliferation, and for treating and preventing conditions associated with smooth muscle cell proliferation, by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII) analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to the subject.
Inventors:
RODGERS KATHLEEN E (US)
DIZEREGA GERE S (US)
DIZEREGA GERE S (US)
Application Number:
PCT/US2001/002768
Publication Date:
July 25, 2002
Filing Date:
January 26, 2001
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
RODGERS KATHLEEN E (US)
DIZEREGA GERE S (US)
RODGERS KATHLEEN E (US)
DIZEREGA GERE S (US)
International Classes:
A61K38/08; A61P21/00; C07K5/093; C07K5/097; C07K5/103; C07K5/113; C07K7/14; A61K38/00; (IPC1-7): A61K38/08; A61P21/00; C07K7/14
Domestic Patent References:
| WO1996037213A1 | 1996-11-28 | |||
| WO1994000492A1 | 1994-01-06 | |||
| WO1999031125A1 | 1999-06-24 | |||
| WO1996039164A1 | 1996-12-12 |
Foreign References:
| EP0914828A2 | 1999-05-12 |
Other References:
FREEMAN ERNEST J ET AL: "Angiotensin-(1-7) inhibits vascular smooth muscle cell growth.", HYPERTENSION (DALLAS), vol. 28, no. 1, 1996, pages 104 - 108, XP002173556, ISSN: 0194-911X
KONO T ET AL: "BIOLOGICAL ACTIVITIES OF ANGIOTENSIN II-1-6-HEXAPEPTIDE AND ANGIOTENSIN II-1-7-HEPTAPEPTIDE IN MAN", LIFE SCIENCES, vol. 38, no. 16, 1986, pages 1515 - 1520, XP001015501, ISSN: 0024-3205
KONO T ET AL: "BIOLOGICAL ACTIVITIES OF ANGIOTENSIN II-1-6-HEXAPEPTIDE AND ANGIOTENSIN II-1-7-HEPTAPEPTIDE IN MAN", LIFE SCIENCES, vol. 38, no. 16, 1986, pages 1515 - 1520, XP001015501, ISSN: 0024-3205
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