Title:
METHODS OF ISOLATING ALLERGEN-SPECIFIC ANTIBODIES FROM HUMANS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/222679
Kind Code:
A3
Abstract:
In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.
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Inventors:
CROOTE DEREK (US)
QUAKE STEPHEN (US)
NADEAU KARI (US)
DARMANIS SPYROS (US)
CORNFIELD DAVID (US)
QUAKE STEPHEN (US)
NADEAU KARI (US)
DARMANIS SPYROS (US)
CORNFIELD DAVID (US)
Application Number:
PCT/US2019/032951
Publication Date:
December 26, 2019
Filing Date:
May 17, 2019
Export Citation:
Assignee:
CHAN ZUCKERBERG BIOHUB INC (US)
UNIV LELAND STANFORD JUNIOR (US)
UNIV LELAND STANFORD JUNIOR (US)
International Classes:
C07K16/00; C07K14/705; C12N5/0781; G01N33/533; G01N33/577
Foreign References:
| US20160058377A1 | 2016-03-03 |
Other References:
HOH ET AL.: "Single B- cell deconvolution of peanut-specific antibody responses in allergic patients", J ALLERGY CLIN IMMUNOL, vol. 137, no. 1, January 2016 (2016-01-01), pages 157 - 167, XP029379350, DOI: 10.1016/j.jaci.2015.05.029
ZHANG ET AL.: "Blocking Allergic Reaction through Targeting Surface-Bound IgE with Low-Affinity Anti-IgE Antibodies", J IMMUNOL, vol. 198, no. 10, 15 May 2017 (2017-05-15), pages 3823 - 3834, XP055667885
MATTOO ET AL.: "De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease", J ALLERGY CLIN IMMUNO L, vol. 134, no. 3, September 2014 (2014-09-01), pages 679 - 687, XP055311070, DOI: 10.1016/j.jaci.2014.03.034
ANONYMOUS: "Human Ig Isotyping Antibody Array (8 Targets) - Quantitative ab197452", 17 April 2015 (2015-04-17), pages 1 - 3, XP009524791, Retrieved from the Internet [retrieved on 20191015]
KURUP ET AL.: "Fungal allergens and peptide epitopes", PEPTIDES, vol. 21, no. 4, April 2000 (2000-04-01), pages 589 - 599, XP001016244, DOI: 10.1016/S0196-9781(00)00181-9
ZHANG ET AL.: "Blocking Allergic Reaction through Targeting Surface-Bound IgE with Low-Affinity Anti-IgE Antibodies", J IMMUNOL, vol. 198, no. 10, 15 May 2017 (2017-05-15), pages 3823 - 3834, XP055667885
MATTOO ET AL.: "De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease", J ALLERGY CLIN IMMUNO L, vol. 134, no. 3, September 2014 (2014-09-01), pages 679 - 687, XP055311070, DOI: 10.1016/j.jaci.2014.03.034
ANONYMOUS: "Human Ig Isotyping Antibody Array (8 Targets) - Quantitative ab197452", 17 April 2015 (2015-04-17), pages 1 - 3, XP009524791, Retrieved from the Internet
KURUP ET AL.: "Fungal allergens and peptide epitopes", PEPTIDES, vol. 21, no. 4, April 2000 (2000-04-01), pages 589 - 599, XP001016244, DOI: 10.1016/S0196-9781(00)00181-9
Attorney, Agent or Firm:
YAO, Zhengzheng et al. (US)
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