Title:
METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER
Document Type and Number:
WIPO Patent Application WO2002076280
Kind Code:
A3
Abstract:
Methods and kits for (i) determining a risk of a subject to develop cancer; (ii) evaluating an effectiveness and dosage of cancer therapy administered to a cancer patient; and (iii) determining a presence of correlation or non-correlation between an activity of at least one DNA repair enzyme and at least one cancer, are disclosed.
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Inventors:
LIVNEH ZVI (IL)
PAZ-ELIZUR TAMAR (IL)
BLUMENSTEIN SARA (IL)
PAZ-ELIZUR TAMAR (IL)
BLUMENSTEIN SARA (IL)
Application Number:
PCT/IL2002/000231
Publication Date:
March 18, 2004
Filing Date:
March 21, 2002
Export Citation:
Assignee:
YEDA RES & DEV (IL)
LIVNEH ZVI (IL)
PAZ-ELIZUR TAMAR (IL)
BLUMENSTEIN SARA (IL)
LIVNEH ZVI (IL)
PAZ-ELIZUR TAMAR (IL)
BLUMENSTEIN SARA (IL)
International Classes:
C12Q1/34; C12Q1/527; C12Q1/68; G01N33/574; C12N15/09; (IPC1-7): C12Q1/68; C12P19/34; C07H21/02; C07H21/04
Foreign References:
| US5482833A | 1996-01-09 | |||
| US5482837A | 1996-01-09 | |||
| US20010031739A1 | 2001-10-18 |
Other References:
ASAMI ET AL.: "Increase of a type of oxidative DNA damage, 8-hydroxyguanine and its repair activity in human leukocytes by cigarette smoking", CANCER RESEARCH, vol. 56, 1 June 1996 (1996-06-01), pages 2546 - 2549, XP002964058
SHINMURA ET AL.: "Infrequent mutations of the hOGGI gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer", JAPANESE JOURNAL OF CANCER RESEARCH, vol. 89, August 1998 (1998-08-01), pages 825 - 828, XP002964057
KOW ET AL.: "Detection of abasic sites and oxidative DNA base damage using an ELISA-like assay", METHODS, vol. 22, 2000, pages 164 - 169, XP002964056
BOUZIANE ET AL.: "Promoter structure and cell cycle dependent expression of the human methylpurine DNA glycosylase gene", MUTATION RESEARCH, vol. 461, 2000, pages 15 - 29, XP002964055
SHINMURA ET AL.: "Infrequent mutations of the hOGGI gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer", JAPANESE JOURNAL OF CANCER RESEARCH, vol. 89, August 1998 (1998-08-01), pages 825 - 828, XP002964057
KOW ET AL.: "Detection of abasic sites and oxidative DNA base damage using an ELISA-like assay", METHODS, vol. 22, 2000, pages 164 - 169, XP002964056
BOUZIANE ET AL.: "Promoter structure and cell cycle dependent expression of the human methylpurine DNA glycosylase gene", MUTATION RESEARCH, vol. 461, 2000, pages 15 - 29, XP002964055
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