Title:
METHODS FOR MAKING CELLS WITH AN EXTRA-EMBRYONIC ENDODERMAL PRECURSOR PHENOTYPE
Document Type and Number:
WIPO Patent Application WO/2012/104731
Kind Code:
A3
Abstract:
The invention is directed to methods for making cells in vitro that have an extra-embryonic endodermal precursor phenotype. The method involves culturing cells from blastocysts under specific defined conditions.
Inventors:
VERFAILLIE CATHERINE M (BE)
BINAS BERT (KR)
BINAS BERT (KR)
Application Number:
PCT/IB2012/000413
Publication Date:
November 15, 2012
Filing Date:
January 30, 2012
Export Citation:
Assignee:
UNIV LEUVEN KATH (BE)
VERFAILLIE CATHERINE M (BE)
BINAS BERT (KR)
VERFAILLIE CATHERINE M (BE)
BINAS BERT (KR)
International Classes:
C12N5/0735
Foreign References:
| US20080182328A1 | 2008-07-31 |
Other References:
GALAT VASILIY ET AL: "Developmental potential of rat extraembryonic stem cells.", STEM CELLS AND DEVELOPMENT NOV 2009 LNKD- PUBMED:19480599, vol. 18, no. 9, November 2009 (2009-11-01), pages 1309 - 1318, XP002683425, ISSN: 1557-8534
BISRAT G. DEBEB ET AL: "Isolation of Oct4-Expressing Extraembryonic Endoderm Precursor Cell Lines", PLOS ONE, vol. 4, no. 9, 1 January 2009 (2009-01-01), pages e7216, XP055037949, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0007216
KEMAR BROWN ET AL: "A Comparative Analysis of Extra-Embryonic Endoderm Cell Lines", PLOS ONE, vol. 5, no. 8, 1 January 2010 (2010-01-01), pages e12016 - e12016, XP055038053, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0012016
J. ARTUS ET AL: "A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst", DEVELOPMENT, vol. 137, no. 20, 15 October 2010 (2010-10-15), pages 3361 - 3372, XP055037952, ISSN: 0950-1991, DOI: 10.1242/dev.050864
JEREMY G. THOMPSON: "Defining the requirements for bovine embryo culture", THERIOGENOLOGY, vol. 45, no. 1, 1 January 1996 (1996-01-01), pages 27 - 40, XP055038055, ISSN: 0093-691X, DOI: 10.1016/0093-691X(95)00352-9
ROSSANT JANET: "Stem cells and lineage development in the mammalian blastocyst", REPRODUCTION, FERTILITY AND DEVELOPMENT, CSIRO, EAST MELBOURNE, AU, vol. 19, no. 1, 1 January 2007 (2007-01-01), pages 111 - 118, XP009162784, ISSN: 1031-3613
BISRAT G. DEBEB ET AL: "Isolation of Oct4-Expressing Extraembryonic Endoderm Precursor Cell Lines", PLOS ONE, vol. 4, no. 9, 1 January 2009 (2009-01-01), pages e7216, XP055037949, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0007216
KEMAR BROWN ET AL: "A Comparative Analysis of Extra-Embryonic Endoderm Cell Lines", PLOS ONE, vol. 5, no. 8, 1 January 2010 (2010-01-01), pages e12016 - e12016, XP055038053, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0012016
J. ARTUS ET AL: "A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst", DEVELOPMENT, vol. 137, no. 20, 15 October 2010 (2010-10-15), pages 3361 - 3372, XP055037952, ISSN: 0950-1991, DOI: 10.1242/dev.050864
JEREMY G. THOMPSON: "Defining the requirements for bovine embryo culture", THERIOGENOLOGY, vol. 45, no. 1, 1 January 1996 (1996-01-01), pages 27 - 40, XP055038055, ISSN: 0093-691X, DOI: 10.1016/0093-691X(95)00352-9
ROSSANT JANET: "Stem cells and lineage development in the mammalian blastocyst", REPRODUCTION, FERTILITY AND DEVELOPMENT, CSIRO, EAST MELBOURNE, AU, vol. 19, no. 1, 1 January 2007 (2007-01-01), pages 111 - 118, XP009162784, ISSN: 1031-3613
Attorney, Agent or Firm:
HOLLYWOOD, Jane Constance (20 Red Lion Street, London WC1R 4PJ, GB)
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