Title:
METHODS OF MAKING IMPROVED HUMAN INTESTINAL ORGANOID COMPOSITIONS VIA APPLICATION OF STRAIN AND HUMAN INTESTINAL ORGANOID COMPOSITIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/200481
Kind Code:
A8
Abstract:
Disclosed herein are methods of enhancing development of a three-dimensional in vitro model of an intestinal tissue (HIO), which may be derived from a precursor cell. The precursor cell may be, for example, an embryonic stem cell, an induced pluripotent stem cell (iPSC), or the like. The in vitro HIO model may be characterized in that the HIO has a lumen, in which a lengthening device may be inserted to promote development of the HIO. Compositions derived from the disclosed methods are also described.
Inventors:
MAHE MAXIME MICKAEL (FR)
HELMRATH MICHAEL (US)
POLING HOLLY (US)
WELLS JAMES (US)
HELMRATH MICHAEL (US)
POLING HOLLY (US)
WELLS JAMES (US)
Application Number:
PCT/US2018/029083
Publication Date:
December 06, 2018
Filing Date:
April 24, 2018
Export Citation:
Assignee:
CHILDRENS HOSPITAL MED CT (US)
MAHE MAXIME MICKAEL (FR)
HELMRATH MICHAEL A (US)
MAHE MAXIME MICKAEL (FR)
HELMRATH MICHAEL A (US)
International Classes:
C12N5/071; A61F2/88; A61P1/00; C12Q1/02
Attorney, Agent or Firm:
TEPE, Nicole, M. et al. (US)
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