Title:
METHODS FOR MANUFACTURING POLYSACCHARIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2004024774
Kind Code:
A3
Abstract:
The invention is based upon the discovery that insoluble, polysaccharides, such as inulin and dextran, can be enzymatically modified in an organic solvent. Thus, the invention relates to methods for making a high molecular weight polyhydroxy polymer, such as a polysaccharide, inulin or dextran derivative, comprising reacting an acyl donor and the polymer, such as inulin or dextran, to form an acyl ester of the polymer, such as inulin dextran, in a reaction medium comprising an organic solvent in the presence of a hydrolytic enzyme; methods for making a polymer, such as a polysaccharide, an inulin or dextran polymer, comprising reacting a polymerizable acyl donor and polyhydroxyl polymer in a reaction medium comprising an organic solvent in the presence of a hydrolytic enzyme thereby making an polymeric monomer, such as an inulin monomer, and polymerizing, preferably dimerizing, the monomer, thereby making a novel polymer, such as an inulin polymer. The invention further relates to novel products as can be produced by the processes described herein, pharmaceutical compositions containing them and the use of the novel polymers described herein in methods for the manufacture of a pharmaceutical composition or medicament. Further, the invention relates to a method of delivering an active agent to a patient comprising administering to the patient a pharmaceutical composition described herein.
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Inventors:
DORDICK JONATHON S
FERREIRA LINO
FERREIRA LINO
Application Number:
PCT/US2003/029290
Publication Date:
June 03, 2004
Filing Date:
September 15, 2003
Export Citation:
Assignee:
RENSSELAER POLYTECH INST (US)
BIOTECHNOLOGY RES & DEV (US)
BIOTECHNOLOGY RES & DEV (US)
International Classes:
C08B37/00; C08B37/02; C12P19/04; C12P19/08; (IPC1-7): C07H1/00; C07H3/00; C12Q1/34; C12Q1/37
Foreign References:
| US5854030A | 1998-12-29 | |||
| US6063916A | 2000-05-16 | |||
| US6120751A | 2000-09-19 |
Other References:
FERREIRA L. ET AL.: "Enzymatic synthesis of inulin-contatining hydrogels", BIOMACROMOLECULES, vol. 3, 2002, pages 333 - 341, XP002975284
FERREIRA L. ET AL.: "Enzymatic synthesis of dextran-containing hydrogels", BIOMATERIALS, vol. 23, 2002, pages 3957 - 3967, XP004374388
BRUNO F.F. ET AL.: "Regioselective enzymatic transesterification of polysaccharides in organic solvent", POLYMERIC MATERIALS SCIENCE AND ENGINEERING, vol. 74, 1996, pages 65 - 70, XP002975285
FERREIRA L. ET AL.: "Enzymatic synthesis of dextran-containing hydrogels", BIOMATERIALS, vol. 23, 2002, pages 3957 - 3967, XP004374388
BRUNO F.F. ET AL.: "Regioselective enzymatic transesterification of polysaccharides in organic solvent", POLYMERIC MATERIALS SCIENCE AND ENGINEERING, vol. 74, 1996, pages 65 - 70, XP002975285
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