METHODS AND MEANS FOR MODULATING THE IMMUNE RESPONSE

Title:

METHODS AND MEANS FOR MODULATING THE IMMUNE RESPONSE

Document Type and Number:

WIPO Patent Application WO2003052424

Kind Code:

A3

Abstract:

c-kit (CD117), STAT3, stem cell factor (SCF) and leukaemia inhibiting factor (LIF) are elevated in tolerant immune responses. These may be used in modulation of the immune response generated to an antigen, in particular controlling the presence or degree of tolerance an individual has to an antigen, whether foreign or self. The immune status of an individual, for example with reference to an antigen, may be determined by testing c-kit (CD117), STAT3, stem cell factor (SCF) and/or leukaemia inhibiting factor (LIF) levels.

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Inventors:

METCALFE SUSAN MARIE (GB)

Application Number:

PCT/GB2002/005679

Publication Date:

September 04, 2003

Filing Date:

December 13, 2002

Export Citation:

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Assignee:

UNIV CAMBRIDGE TECH (GB)
METCALFE SUSAN MARIE (GB)

International Classes:

G01N33/68; (IPC1-7): G01N33/68; A61K38/00

Domestic Patent References:

WO1987005400A1

1987-09-11

Foreign References:

US5965366A

1999-10-12

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