Title:
METHODS FOR MODULATING CANCER CELLS AND STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2015/175500
Kind Code:
A3
Abstract:
The present invention provides methods for modulating pluripotency of stem cells and proliferation of cancer cells. The modulation is achieved by promoting dephosphorylation of mRNA-binding protein 3 (RBM3) and down-regulating expression or cellular level of pluripotency factor LIN28. Related methods are provided in the invention for promoting differentiation of stem cells and for inhibiting growth of tumors in subjects. The therapeutic methods of the invention typically entail contacting with a target cell (e.g., a tumor cell) or administering to a subject harboring the target cell a calpain inhibitor and/or an IGF1R inhibitor. Some methods of the invention employ both a calpain inhibitor and an IGF 1R inhibitor.
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Inventors:
VANDERKLISH PETER W (US)
SPEVAK CHRISTINA (US)
SPEVAK CHRISTINA (US)
Application Number:
PCT/US2015/030322
Publication Date:
December 30, 2015
Filing Date:
May 12, 2015
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
International Classes:
A61K38/55; A61K39/395; A61P35/00
Domestic Patent References:
| WO2001074381A2 | 2001-10-11 |
Foreign References:
| US7939272B2 | 2011-05-10 | |||
| US20110105732A1 | 2011-05-05 | |||
| US20130198876A1 | 2013-08-01 | |||
| US20140105969A1 | 2014-04-17 | |||
| US20130095071A1 | 2013-04-18 |
Other References:
SPENCE ET AL.: "A novel C19 MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes.", NEURO-ONCOLOGY, vol. 16, no. 1, 4 December 2013 (2013-12-04), pages 62 - 71, XP055245662
Attorney, Agent or Firm:
FITTING, Thomas et al. (10550 North Torrey Pines Road TPC-, La Jolla CA, US)
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