Title:
METHODS FOR MONITORING DRUG ACTIVITIES IN VIVO
Document Type and Number:
WIPO Patent Application WO2004094673
Kind Code:
A3
Abstract:
Methods, systems and equipment useful for monitoring in vivo activities of CCI-779 or other drugs. Numerous drug activity genes can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells are modulateable by CCI-779 or other drugs. Therefore, these genes can be used as surrogate markers for detecting or monitoring drug activities in vivo.
Inventors:
BURCZYNSKI MICHAEL E (US)
BONI JOSEPH (US)
FITZPATRICK VIRGINIA (US)
TWINE NATALIE C (US)
STOVER JENNIFER (US)
DORNER ANDREW (US)
IMMERMAN FRED (US)
TREPICCHIO WILLIAM (US)
BONI JOSEPH (US)
FITZPATRICK VIRGINIA (US)
TWINE NATALIE C (US)
STOVER JENNIFER (US)
DORNER ANDREW (US)
IMMERMAN FRED (US)
TREPICCHIO WILLIAM (US)
Application Number:
PCT/US2004/006601
Publication Date:
March 24, 2005
Filing Date:
March 05, 2004
Export Citation:
Assignee:
WYETH CORP (US)
BURCZYNSKI MICHAEL E (US)
BONI JOSEPH (US)
FITZPATRICK VIRGINIA (US)
TWINE NATALIE C (US)
STOVER JENNIFER (US)
DORNER ANDREW (US)
IMMERMAN FRED (US)
TREPICCHIO WILLIAM (US)
BURCZYNSKI MICHAEL E (US)
BONI JOSEPH (US)
FITZPATRICK VIRGINIA (US)
TWINE NATALIE C (US)
STOVER JENNIFER (US)
DORNER ANDREW (US)
IMMERMAN FRED (US)
TREPICCHIO WILLIAM (US)
International Classes:
A61K38/17; C07K16/18; C12Q1/68; G01N33/53; G01N33/567; C12N; (IPC1-7): C12Q1/68; C07K16/18; G01N33/53
Domestic Patent References:
| WO2000040749A2 | 2000-07-13 | |||
| WO2002040000A2 | 2002-05-23 | |||
| WO2001081916A2 | 2001-11-01 | |||
| WO2003032813A2 | 2003-04-24 | |||
| WO2004072265A2 | 2004-08-26 | |||
| WO2004048933A2 | 2004-06-10 |
Other References:
BURCZYNSKI ET AL.: "Pharmacogenomic expression profiling of renal cell carcinoma in a phase II trial of CCI-779: identification of surrogate markers of disease and predictors of outcome in the compartment of peripheral blood", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 38, November 2002 (2002-11-01), pages S51, XP002295167, ISSN: 0959-8049
SCHULZE-KOOPS H ET AL: "Persistent reduction in IL-6 mRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis after treatment with a monoclonal antibody to CD54 (ICAM-1).", CLINICAL AND EXPERIMENTAL IMMUNOLOGY. NOV 1996, vol. 106, no. 2, November 1996 (1996-11-01), pages 190 - 196, XP002295168, ISSN: 0009-9104
DIPAOLA R S ET AL: "Phase I clinical and pharmacologic study of 13-cis-retinoic acid, interferon alfa, and paclitaxel in patients with prostate cancer and other advanced malignancies.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY. JUL 1999, vol. 17, no. 7, July 1999 (1999-07-01), pages 2213 - 2218, XP002295169, ISSN: 0732-183X
"Product Catalogue", January 2001, AFFYMETRIX, XP002301464
LICHTENFELS R ET AL: "Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1646, no. 1-2, 21 March 2003 (2003-03-21), pages 21 - 31, XP004413484
SU ANDREW I ET AL: "Large-scale analysis of the human and mouse transcriptomes.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2 APR 2002, vol. 99, no. 7, 2 April 2002 (2002-04-02), pages 4465 - 4470, XP002301463, ISSN: 0027-8424
ELIT LAURIE: "CCI-779 Wyeth.", CURRENT OPINION IN INVESTIGATIONAL DRUGS (LONDON, ENGLAND : 2000) AUG 2002, vol. 3, no. 8, August 2002 (2002-08-01), pages 1249 - 1253, XP008037562, ISSN: 1472-4472
PERALBA JOSEP-MARIA ET AL: "Pharmacodynamic evaluation of the rapamycin ester CCI-779", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 43, March 2002 (2002-03-01), & 93RD ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; SAN FRANCISCO, CALIFORNIA, USA; APRIL 06-10, 2002, pages 1000 - 1001, XP001182924, ISSN: 0197-016X
RININGER J A ET AL: "Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity", DRUG DISCOVERY TODAY 01 DEC 2000 UNITED KINGDOM, vol. 5, no. 12, 1 December 2000 (2000-12-01), pages 560 - 568, XP002295171, ISSN: 1359-6446
PERALBA JOSEP MARIA ET AL: "Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. 1 AUG 2003, vol. 9, no. 8, 1 August 2003 (2003-08-01), pages 2887 - 2892, XP002295172, ISSN: 1078-0432
SCHULZE-KOOPS H ET AL: "Persistent reduction in IL-6 mRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis after treatment with a monoclonal antibody to CD54 (ICAM-1).", CLINICAL AND EXPERIMENTAL IMMUNOLOGY. NOV 1996, vol. 106, no. 2, November 1996 (1996-11-01), pages 190 - 196, XP002295168, ISSN: 0009-9104
DIPAOLA R S ET AL: "Phase I clinical and pharmacologic study of 13-cis-retinoic acid, interferon alfa, and paclitaxel in patients with prostate cancer and other advanced malignancies.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY. JUL 1999, vol. 17, no. 7, July 1999 (1999-07-01), pages 2213 - 2218, XP002295169, ISSN: 0732-183X
"Product Catalogue", January 2001, AFFYMETRIX, XP002301464
LICHTENFELS R ET AL: "Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1646, no. 1-2, 21 March 2003 (2003-03-21), pages 21 - 31, XP004413484
SU ANDREW I ET AL: "Large-scale analysis of the human and mouse transcriptomes.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2 APR 2002, vol. 99, no. 7, 2 April 2002 (2002-04-02), pages 4465 - 4470, XP002301463, ISSN: 0027-8424
ELIT LAURIE: "CCI-779 Wyeth.", CURRENT OPINION IN INVESTIGATIONAL DRUGS (LONDON, ENGLAND : 2000) AUG 2002, vol. 3, no. 8, August 2002 (2002-08-01), pages 1249 - 1253, XP008037562, ISSN: 1472-4472
PERALBA JOSEP-MARIA ET AL: "Pharmacodynamic evaluation of the rapamycin ester CCI-779", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 43, March 2002 (2002-03-01), & 93RD ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; SAN FRANCISCO, CALIFORNIA, USA; APRIL 06-10, 2002, pages 1000 - 1001, XP001182924, ISSN: 0197-016X
RININGER J A ET AL: "Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity", DRUG DISCOVERY TODAY 01 DEC 2000 UNITED KINGDOM, vol. 5, no. 12, 1 December 2000 (2000-12-01), pages 560 - 568, XP002295171, ISSN: 1359-6446
PERALBA JOSEP MARIA ET AL: "Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. 1 AUG 2003, vol. 9, no. 8, 1 August 2003 (2003-08-01), pages 2887 - 2892, XP002295172, ISSN: 1078-0432
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