Title:
METHODS FOR NUCLEIC ACID CAPTURE AND SEQUENCING
Document Type and Number:
WIPO Patent Application WO/2012/027572
Kind Code:
A3
Abstract:
Methods of capturing and sequencing target nucleic acid molecules are provided. Methods of determining the methylation status of genomic DNA are also provided.
Inventors:
SESHAGIRI SOMASEKAR (US)
Application Number:
PCT/US2011/049151
Publication Date:
June 07, 2012
Filing Date:
August 25, 2011
Export Citation:
Assignee:
GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)
SESHAGIRI SOMASEKAR (US)
HOFFMANN LA ROCHE (CH)
SESHAGIRI SOMASEKAR (US)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2008103848A1 | 2008-08-28 | |||
| WO1989011546A1 | 1989-11-30 | |||
| WO2010027497A2 | 2010-03-11 | |||
| WO2008096146A1 | 2008-08-14 |
Foreign References:
| US6982146B1 | 2006-01-03 | |||
| US20090047680A1 | 2009-02-19 |
Other References:
KHODAKOV DMITRY A ET AL: "An oligonucleotide microarray for multiplex real-time PCR identification of HIV-1HBV and HCV", BIOTECHNIQUES, vol. 44, no. 2, February 2008 (2008-02-01), pages 241 - 246,248, XP002664414, ISSN: 0736-6205
AKSYONOV S A ET AL: "Multiplexed DNA sequencing-by-synthesis", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 348, no. 1, 1 January 2006 (2006-01-01), pages 127 - 138, XP024941957, ISSN: 0003-2697, [retrieved on 20060101], DOI: 10.1016/J.AB.2005.10.001
EMILY HODGES ET AL: "High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, vol. 19, no. 9, 1 January 2009 (2009-01-01), pages 1593 - 1605, XP002658586, ISSN: 1088-9051, [retrieved on 20090706], DOI: 10.1101/GR.095190.109
WAN ET AL: "Bisulfite modification of immobilized DNAs for methylation detection", BIOSENSORS AND BIOELECTRONICS, ELSEVIER BV, NL, vol. 22, no. 11, 30 March 2007 (2007-03-30), pages 2415 - 2421, XP022006435, ISSN: 0956-5663, DOI: 10.1016/J.BIOS.2006.08.033
AKSYONOV S A ET AL: "Multiplexed DNA sequencing-by-synthesis", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 348, no. 1, 1 January 2006 (2006-01-01), pages 127 - 138, XP024941957, ISSN: 0003-2697, [retrieved on 20060101], DOI: 10.1016/J.AB.2005.10.001
EMILY HODGES ET AL: "High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, vol. 19, no. 9, 1 January 2009 (2009-01-01), pages 1593 - 1605, XP002658586, ISSN: 1088-9051, [retrieved on 20090706], DOI: 10.1101/GR.095190.109
WAN ET AL: "Bisulfite modification of immobilized DNAs for methylation detection", BIOSENSORS AND BIOELECTRONICS, ELSEVIER BV, NL, vol. 22, no. 11, 30 March 2007 (2007-03-30), pages 2415 - 2421, XP022006435, ISSN: 0956-5663, DOI: 10.1016/J.BIOS.2006.08.033
Attorney, Agent or Firm:
PASQUALONE, Danielle, M. et al. (Inc.1 DNA Way, MS-4, South San Francisco CA, US)
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