Title:
METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELL PROLIFERATIVE DISORDERS
Document Type and Number:
WIPO Patent Application WO/2010/007083
Kind Code:
A3
Abstract:
The invention provides methods, nucleic acids and kits for determining the prognosis of a subject having cell proliferative disorder, preferably cancer. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
Inventors:
DIETRICH DIMO (DE)
LESCHE RALF (DE)
FASSBENDER ANNE (DE)
KRISPIN MANUEL (DE)
DIETRICH JOERN (DE)
LESCHE RALF (DE)
FASSBENDER ANNE (DE)
KRISPIN MANUEL (DE)
DIETRICH JOERN (DE)
Application Number:
PCT/EP2009/059034
Publication Date:
March 11, 2010
Filing Date:
July 15, 2009
Export Citation:
Assignee:
EPIGENOMICS AG (DE)
DIETRICH DIMO (DE)
LESCHE RALF (DE)
FASSBENDER ANNE (DE)
KRISPIN MANUEL (DE)
DIETRICH JOERN (DE)
DIETRICH DIMO (DE)
LESCHE RALF (DE)
FASSBENDER ANNE (DE)
KRISPIN MANUEL (DE)
DIETRICH JOERN (DE)
International Classes:
C12Q1/68
Domestic Patent References:
| WO1999028498A2 | 1999-06-10 | |||
| WO2007010258A2 | 2007-01-25 | |||
| WO2007085497A2 | 2007-08-02 | |||
| WO2005100606A2 | 2005-10-27 |
Foreign References:
| US20070264659A1 | 2007-11-15 | |||
| US20050100933A1 | 2005-05-12 | |||
| US6200756B1 | 2001-03-13 |
Other References:
BOOKEN N ET AL: "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3.", LEUKEMIA : OFFICIAL JOURNAL OF THE LEUKEMIA SOCIETY OF AMERICA, LEUKEMIA RESEARCH FUND, U.K FEB 2008, vol. 22, no. 2, 22 November 2007 (2007-11-22), pages 393 - 399, XP007910321, ISSN: 1476-5551
WANG JIANYONG ET AL: "Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells.", NEUROCHEMISTRY INTERNATIONAL MAY 2008, vol. 52, no. 6, 4 November 2007 (2007-11-04), pages 1037 - 1043, XP022558188, ISSN: 0197-0186
LI LIAN-FANG ET AL: "Integrated gene expression profile predicts prognosis of breast cancer patients.", BREAST CANCER RESEARCH AND TREATMENT JAN 2009, vol. 113, no. 2, 16 February 2008 (2008-02-16), pages 231 - 237, XP019671303, ISSN: 1573-7217
HESS KENNETH R ET AL: "Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 10 SEP 2006, vol. 24, no. 26, 10 September 2006 (2006-09-10), pages 4236 - 4244, XP002485594, ISSN: 1527-7755
See also references of EP 2321431A2
WANG JIANYONG ET AL: "Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells.", NEUROCHEMISTRY INTERNATIONAL MAY 2008, vol. 52, no. 6, 4 November 2007 (2007-11-04), pages 1037 - 1043, XP022558188, ISSN: 0197-0186
LI LIAN-FANG ET AL: "Integrated gene expression profile predicts prognosis of breast cancer patients.", BREAST CANCER RESEARCH AND TREATMENT JAN 2009, vol. 113, no. 2, 16 February 2008 (2008-02-16), pages 231 - 237, XP019671303, ISSN: 1573-7217
HESS KENNETH R ET AL: "Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 10 SEP 2006, vol. 24, no. 26, 10 September 2006 (2006-09-10), pages 4236 - 4244, XP002485594, ISSN: 1527-7755
See also references of EP 2321431A2
Attorney, Agent or Firm:
BOEHMERT & BOEHMERT (Jan B.Pettenkoferstraße 20-22, Munich, DE)
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