Title:
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING TUMOUR CELL GROWTH
Document Type and Number:
WIPO Patent Application WO1998025598
Kind Code:
A3
Abstract:
Methods for inhibiting proliferation of a PPAR gamma -responsive hyperproliferative cell using PPAR gamma agonists are described. Pharmaceutical compositions as well as methods for diagnosing and treating a PPAR gamma -responsive hyperproliferative cell are also described. 00000
Inventors:
SPIEGELMAN BRUCE M (US)
ALTIOK SONER (US)
MULLER ELIZABETH (US)
SERRAF PASHA (US)
TONTONOZ PETER (US)
ALTIOK SONER (US)
MULLER ELIZABETH (US)
SERRAF PASHA (US)
TONTONOZ PETER (US)
Application Number:
PCT/US1997/022879
Publication Date:
July 30, 1998
Filing Date:
December 11, 1997
Export Citation:
Assignee:
DANA FARBER CANCER INST INC (US)
SPIEGELMAN BRUCE M (US)
ALTIOK SONER (US)
MULLER ELIZABETH (US)
SERRAF PASHA (US)
TONTONOZ PETER (US)
SPIEGELMAN BRUCE M (US)
ALTIOK SONER (US)
MULLER ELIZABETH (US)
SERRAF PASHA (US)
TONTONOZ PETER (US)
International Classes:
A61K31/421; C07D291/04; A61K31/422; A61K31/425; A61K31/426; A61K31/427; A61K31/433; A61K31/4439; A61K45/00; A61K45/06; A61P35/00; A61P35/02; C07D263/56; C07D285/12; C07D413/14; C07D417/06; C07D417/12; (IPC1-7): A61K31/00
Domestic Patent References:
| WO1995035108A1 | 1995-12-28 | |||
| WO1996033724A2 | 1996-10-31 | |||
| WO1996034943A1 | 1996-11-07 | |||
| WO1993021146A1 | 1993-10-28 | |||
| WO1995010271A2 | 1995-04-20 | |||
| WO1996040128A2 | 1996-12-19 | |||
| WO1997017091A1 | 1997-05-15 |
Other References:
YU K ET AL: "DIFFERENTIAL ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS BY EICOSANOIDS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 41, 1995, pages 23975 - 23983, XP000615426
LAMBE ET AL.: "A human peroxysome-proliferator-activated receptor gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs", EUR. J. BIOCHEM., vol. 239, 1996, pages 1 - 7, XP002062380
ADACHI H ET AL: "SUPPRESSION BY RETINOIDS OF THE SUPPRESSION BY RETINOIDS OF THE INDUCTION OF THE CCAAT/ENHANCER-BINDING PROTEIN ALPHA AND THE NUCLEAR RECEPTORS PPARGAMMA AND RORGAMMA DURING ADIPOCYTE DIFFERENTIATION OF 3T3-L1 CELLS", MOLECULAR AND CELLULAR DIFFERENTIATION, vol. 4, no. 4, 1996, pages 365 - 381, XP000673616
LEHMANN J M ET AL: "AN ANTIDIABETIC THIAZOLIDINEDIONE IS A HIGH AFFINITY LIGAND FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPARGAMMA)", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 22, 2 June 1995 (1995-06-02), pages 12953 - 12956, XP000577082
FORMAN B M ET AL: "15-DEOXY-DELTA 12,14-PROSTAGLANDIN J2 IS A LIGAND FOR THE ADIPOXYTE DETERMINATION FACTOR PPARY", CELL, vol. 83, 1 December 1995 (1995-12-01), pages 803 - 812, XP000575803
SCHOONJANS K ET AL: "THE PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPARS) AND THEIR EFFECTS ON LIPID METABOLISM AND ADIPOCYTE DIFFERENTIATION", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1302, no. 2, 1996, pages 93 - 109, XP000613806
WEINSTOCK ET AL.: "Pioglitazone: In vitro Effects on Rat Hepatoma Cells and in vivo Liver Hypertrophy in KKA Mice", PHARMACOLOGY, vol. 54, no. 4, 1997, pages 169 - 178, XP002062383
TONTONOZ ET AL.: "Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.", PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 237 - 241, XP002062382
ASOU ET AL.: "Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxysome proliferator activated receptor gamma (PPAR gamma) and retinoids", BLOOD, vol. 90, no. 10 suppl 1 part 2, 1997, pages 284B, XP002062384
SHAO ET AL: "Peroxisome proliferator Activated Receptor gamma, CCAAT/Enhancer-binding Protein alpha, and Cell Cycle status Regulate the Commitment to Adipocyte Differentiation", J. BIOL CHEM., vol. 272, no. 34, 1997, pages 21473 - 21478, XP002062385
SPIEGELMAN ET AL.: "PPAR-gamma and the Transcriptional Basis of Adipogenesis", FASEB JOURNAL, vol. 11, no. 9, 1997, pages a880, XP002062386
GREEN S: "PPAR: A MEDIATOR OF PEROXISOME PROLIFERATOR ACTION", MUTATION RESEARCH, vol. 333, no. 1/02, 1 January 1995 (1995-01-01), pages 101 - 109, XP000577705
LEHMANN ET AL.: "Retinoids Selective for Retinoid X Receptor Response Pathways", SCIENCE, vol. 258, 1992, pages 1944 - 1946, XP002062381
KIYOTO MOTOJIMA: "PEROXISOSME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR): STRUCTURE, MACHANISMS OF ACTIVATION AND DIVERSE FUNCTIONS", CELL STRUCTURE AND FUNCTION, vol. 18, no. 5, 1 October 1993 (1993-10-01), pages 267 - 277, XP000577699
LAMBE ET AL.: "A human peroxysome-proliferator-activated receptor gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs", EUR. J. BIOCHEM., vol. 239, 1996, pages 1 - 7, XP002062380
ADACHI H ET AL: "SUPPRESSION BY RETINOIDS OF THE SUPPRESSION BY RETINOIDS OF THE INDUCTION OF THE CCAAT/ENHANCER-BINDING PROTEIN ALPHA AND THE NUCLEAR RECEPTORS PPARGAMMA AND RORGAMMA DURING ADIPOCYTE DIFFERENTIATION OF 3T3-L1 CELLS", MOLECULAR AND CELLULAR DIFFERENTIATION, vol. 4, no. 4, 1996, pages 365 - 381, XP000673616
LEHMANN J M ET AL: "AN ANTIDIABETIC THIAZOLIDINEDIONE IS A HIGH AFFINITY LIGAND FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPARGAMMA)", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 22, 2 June 1995 (1995-06-02), pages 12953 - 12956, XP000577082
FORMAN B M ET AL: "15-DEOXY-DELTA 12,14-PROSTAGLANDIN J2 IS A LIGAND FOR THE ADIPOXYTE DETERMINATION FACTOR PPARY", CELL, vol. 83, 1 December 1995 (1995-12-01), pages 803 - 812, XP000575803
SCHOONJANS K ET AL: "THE PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPARS) AND THEIR EFFECTS ON LIPID METABOLISM AND ADIPOCYTE DIFFERENTIATION", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1302, no. 2, 1996, pages 93 - 109, XP000613806
WEINSTOCK ET AL.: "Pioglitazone: In vitro Effects on Rat Hepatoma Cells and in vivo Liver Hypertrophy in KKA Mice", PHARMACOLOGY, vol. 54, no. 4, 1997, pages 169 - 178, XP002062383
TONTONOZ ET AL.: "Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.", PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 237 - 241, XP002062382
ASOU ET AL.: "Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxysome proliferator activated receptor gamma (PPAR gamma) and retinoids", BLOOD, vol. 90, no. 10 suppl 1 part 2, 1997, pages 284B, XP002062384
SHAO ET AL: "Peroxisome proliferator Activated Receptor gamma, CCAAT/Enhancer-binding Protein alpha, and Cell Cycle status Regulate the Commitment to Adipocyte Differentiation", J. BIOL CHEM., vol. 272, no. 34, 1997, pages 21473 - 21478, XP002062385
SPIEGELMAN ET AL.: "PPAR-gamma and the Transcriptional Basis of Adipogenesis", FASEB JOURNAL, vol. 11, no. 9, 1997, pages a880, XP002062386
GREEN S: "PPAR: A MEDIATOR OF PEROXISOME PROLIFERATOR ACTION", MUTATION RESEARCH, vol. 333, no. 1/02, 1 January 1995 (1995-01-01), pages 101 - 109, XP000577705
LEHMANN ET AL.: "Retinoids Selective for Retinoid X Receptor Response Pathways", SCIENCE, vol. 258, 1992, pages 1944 - 1946, XP002062381
KIYOTO MOTOJIMA: "PEROXISOSME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR): STRUCTURE, MACHANISMS OF ACTIVATION AND DIVERSE FUNCTIONS", CELL STRUCTURE AND FUNCTION, vol. 18, no. 5, 1 October 1993 (1993-10-01), pages 267 - 277, XP000577699
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