Title:
METHODS OF PRECISE MOLECULAR-LEVEL DETERMINATION OF LIGAND-RECEPTOR INTERACTIONS AND DESIGNING SELECTIVE DRUG COMPOUNDS BASED ON SAID INTERACTIONS
Document Type and Number:
WIPO Patent Application WO2005086611
Kind Code:
A3
Abstract:
The present invention discloses methods of determining highly precise interactions between a membrane protein receptor and various compounds. The methods of the present invention utilize a receptophore model system and nonsense codon suppression methods combined with heterologous in
Inventors:
DOUGHERTY DENNIS A (US)
LESTER HENRY A (US)
SHIVA NIMA (US)
LESTER HENRY A (US)
SHIVA NIMA (US)
Application Number:
PCT/US2004/022041
Publication Date:
October 12, 2006
Filing Date:
July 08, 2004
Export Citation:
Assignee:
NEURION PHARMACEUTICALS INC (US)
DOUGHERTY DENNIS A (US)
LESTER HENRY A (US)
SHIVA NIMA (US)
DOUGHERTY DENNIS A (US)
LESTER HENRY A (US)
SHIVA NIMA (US)
International Classes:
C07K2/00; C07K14/705; G01N33/566; G01N33/68
Other References:
KEYT B. A.: "Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors", J. BIOL. CHEM., vol. 271, no. 10, 1999, pages 5638 - 5646, XP002021131
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