Title:
METHODS FOR PREDICTING SYNERGISTIC DRUG COMBINATION
Document Type and Number:
WIPO Patent Application WO/2022/021012
Kind Code:
A1
Abstract:
A computer-implemented method of determining effects of drug combinations on treatment outcomes. A plurality of genomic and clinical variables are generated from the combination of comprehensive genomic data, EHR data, and clinical treatment data. Based on Cox Proportional Hazards model, independent risk factors, cumulative hazard-ratios, and p-values for the combination of a first drug and a second drug (or a biomarker) are calculated to determine the nature of the combination of the first drug and the second drug (or the biomarker) with respect to treating the disease.
Inventors:
XU QIANG (CN)
WANG GUAN (CN)
ZHANG YI (CN)
WU BING (CN)
WANG GUAN (CN)
ZHANG YI (CN)
WU BING (CN)
Application Number:
PCT/CN2020/104900
Publication Date:
February 03, 2022
Filing Date:
July 27, 2020
Export Citation:
Assignee:
GENOMICARE BIOTECHNOLOGY SHANGHAI CO LTD (CN)
GENOMICARE CLINICAL LABORATORY QIDONG (CN)
GENOMICARE BIOTECHNOLOGY LA CO LTD (CN)
GENOMICARE CLINICAL LABORATORY QIDONG (CN)
GENOMICARE BIOTECHNOLOGY LA CO LTD (CN)
International Classes:
G16H70/40; G06F16/2457
Foreign References:
| US20190392955A1 | 2019-12-26 | |||
| CN109712684A | 2019-05-03 | |||
| CN103065066A | 2013-04-24 | |||
| US20180322249A1 | 2018-11-08 |
Attorney, Agent or Firm:
SHANGHAI SUNHOLD LAW FIRM (CN)
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